gebhart/patrepeval huggingface dataset:
An Elisa for PGE<sub>2</sub>Utilizing Monoclonal Antibody (1988)

An ELISA for PGE2 has been developed which is sensitive to concentrations of 0.5 to 20.0 ng PGE2/ml. Mouse monoclonal anti-PGE2 ascites is utilized in a binding competition between the test sample and an adsorbed conjugate of PGE2-BSA. The antibody which remains bound to the solid phase is quantitated colorimetrically by incubation with alkaline phosphatase-conjugated goat anti-mouse IgG followed by incubation with p-nitro-phenylphosphate. PGE1, PGA1, PGA2, PGB2, 6-keto-PGF1 alpha, PGF2 alpha, 13,14-dihydro-15-keto-PGE2, thromboxane B2 and arachidonic acid showed minimal cross-reactivity with the anti-PGE2. The PGE2 ELISA permits the quantitative analysis of large numbers of samples at a fraction of the cost and time required to process a commercial RIA kit. When linked to the appropriate computer software, data collection and analysis can be performed in less than 10 minutes per 96-well plate. Furthermore, the use of an ELISA system eliminates the radioactive and toxic chemical waste generated by RIA methods.
Evaluation of NC-FinFET Based Subsystem-Level Logic Circuits (2019)

This paper examines metal–ferroelectric–insulator–semiconductor negative-capacitance FinFET (NC-FinFET) based VLSI subsystem-level logic circuits. For the first time, with the aid of a short-channel NC-FinFET compact model, we confirm the functionality and evaluate the standby-power/switching-energy/delay performance of large logic circuits (e.g., dynamic 4-bit Manchester carry-chain adder and the formal hierarchical 32-bit carry-look-ahead adder) employing 14-nm ultra-low-power NC-FinFETs. Our study indicates that the inverse <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ds</sub> -dependence of threshold voltage ( <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> ), also known as the negative drain-induced barrier lowering, of negative-capacitance field-effect transistor is not only acceptable but also beneficial for the speed performance of both the static and pass-transistor logic (PTL) circuits, especially for the PTL at low <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> .
Designing easily manufactured lenses using a global method (2006)

Easily manufactured lenses can be designed using global optimization with the results sorted based on their predicted asbuilt performance. The most easily manufactured lens depends critically on the performance goals.
Detection of meticillin‐resistant <i>staphylococcus aureus</i> (MRSA) colonization in newborn infants using real‐time polymerase chain reaction (PCR) (2010)

PCR methods are sensitive and specific for detection of MRSA colonization in newborn infants of all gestations with results 1-2 days before culture.
Phloroglucinol Inhibits the Bioactivities of Endothelial Progenitor Cells and Suppresses Tumor Angiogenesis in LLC-Tumor-Bearing Mice (2012)

These results suggest a novel role for Phloroglucinol: Phloroglucinol might be a modulator of circulating EPC bioactivities, eventually suppressing tumorigenesis. Therefore, phloroglucinol might be a candidate compound for biosafe drugs that target tumor angiogenesis.
Auto-scaling to minimize cost and meet application deadlines in cloud workflows (2011)

A goal in cloud computing is to allocate (and thus pay for) only those cloud resources that are truly needed. To date, cloud practitioners have pursued schedule-based (e.g., time-of-day) and rule-based mechanisms to attempt to automate this matching between computing requirements and computing resources. However, most of these "auto-scaling" mechanisms only support simple resource utilization indicators and do not specifically consider both user performance requirements and budget concerns. In this paper, we present an approach whereby the basic computing elements are virtual machines (VMs) of various sizes/costs, jobs are specified as workflows, users specify performance requirements by assigning (soft) deadlines to jobs, and the goal is to ensure all jobs are finished within their deadlines at minimum financial cost. We accomplish our goal by dynamically allocating/deallocating VMs and scheduling tasks on the most cost-efficient instances. We evaluate our approach in four representative cloud workload patterns and show cost savings from 9.8% to 40.4% compared to other approaches.
Relationship between exhaled air temperature and exhaled nitric oxide in childhood asthma (2002)

Airway inflammation is a characteristic of asthma. Exhaled nitric oxide (eNO) has been demonstrated to be related to actual levels of airway inflammation in asthmatic patients. The purpose of this study was to investigate whether the temperature of exhaled air is related to eNO levels. Temperature of exhaled air and eNO were measured in 52 asthmatic children with a cross-sectional design. A significant relationship was demonstrated between eNO and temperature of peak and plateau exhaled air temperature. The relationship between both the peak and the plateau values and eNO was more evident when it was corrected for environmental temperature. These results suggest a relationship between exhaled nitric oxide and the temperature of exhaled air in asthmatic patients not treated with systemic steroids.
Age-Dependent Recombination Rates in Human Pedigrees (2011)

In humans, chromosome-number abnormalities have been associated with altered recombination and increased maternal age. Therefore, age-related effects on recombination are of major importance, especially in relation to the mechanisms involved in human trisomies. Here, we examine the relationship between maternal age and recombination rate in humans. We localized crossovers at high resolution by using over 600,000 markers genotyped in a panel of 69 French-Canadian pedigrees, revealing recombination events in 195 maternal meioses. Overall, we observed the general patterns of variation in fine-scale recombination rates previously reported in humans. However, we make the first observation of a significant decrease in recombination rates with advancing maternal age in humans, likely driven by chromosome-specific effects. The effect appears to be localized in the middle section of chromosomal arms and near subtelomeric regions. We postulate that, for some chromosomes, protection against non-disjunction provided by recombination becomes less efficient with advancing maternal age, which can be partly responsible for the higher rates of aneuploidy in older women. We propose a model that reconciles our findings with reported associations between maternal age and recombination in cases of trisomies.
Maternal Exposure to Toxoplasmosis and Risk of Schizophrenia in Adult Offspring (2005)

These findings suggest that maternal exposure to toxoplasmosis may be a risk factor for schizophrenia. The findings may be explained by reactivated infection or an effect of the antibody on the developing fetus. Given that toxoplasmosis is a preventable infection, the findings, if replicated, may have implications for reducing the incidence of schizophrenia.
Diels-Alder Polymers from Resinic Acids (2005)

A new class of polyhydroxyesterimides has been synthesized by the Diels-Alder (DA) reaction between dihydroxyesters of resinic acids (RA) and dihydroxyesters of carboxyphenylmalcimide (CPMI). Dihydroxyesters of RA and CPMI have been synthesized by reaction between of epoxy resins (diglycidyl ether of bisphenol A, diglycidyl ether of hydroquinone and diglycidyl of aniline) and RA and CPMI. These monomers of AA, AB and BB type were then allowed to polymerise under DA reactions. The obtained polymers are solid, brittle, soluble in high and medium polar solvents and present good thermal properties.
[Methylation of the factor IX gene--a basic reason for the mutation causing hemophilia B]. (1995)

The analysis of 750 mutations in the gene of blood coagulation factor IX has been made for 806 patients with haemophilia B. It has been found that 40% of all point mutations take place in 11 "hot spots", i.e., methylated CG sites, and are CG-->TG or CA transitions. Mechanism proposed explains the high rate of these transitions by m5C deamination during replicative DNA methylation and by mistakes of G/T-repair. This is why mutations constantly occur de novo in the factor IX gene, and haemophilia B maintains on a high level. Asymmetry of C-->T and G-->A transitions is found in some CG sites at different DNA chains, and is related to occurring "missense" mutations, which usually escape from the detection. Summing up these substitutions, CG methylation of the factor IX gene contributes to 50% of all point mutations. Thus, mutations in the CG sites take place in overall 48 times more frequently than in other sites of the gene. It has been found that at least 35 new CG sites are a result of sporadic mutations, and methylation and mutations of these sites may cause 14% of substitutions in the factor IX gene. The "hot spots" for T-->C transitions in codon of Ile397 can be a result both of "founder effect" and of recessive mutations in such CG site in mother's parents. It is shown that methylated CTCG sites, as well as G/T-repair mistakes, can be potential sources of 5.4% of mutations in the gene. Thus, from 50 to 70% of all mutations may be the result of the gene methylation in human genome. The analysis of duplex frequencies in the factor IX gene has shown that the loss of 60 CG sites and the accumulation of 8% of mutations may be a result of "fossil" CG methylation. The remained 20 CG sites are located in the codons of those amino acids which positions are more critical for the factor IX activity. It has been proposed that the most radical way in haemophilia B therapy can be a protection of the factor IX gene from methylation in the human genome.
Multiple Dopamine Functions at Different Time Courses (2007)

Many lesion studies report an amazing variety of deficits in behavioral functions that cannot possibly be encoded in great detail by the relatively small number of midbrain dopamine neurons. Although hoping to unravel a single dopamine function underlying these phenomena, electrophysiological and neurochemical studies still give a confusing, mutually exclusive, and partly contradictory account of dopamine's role in behavior. However, the speed of observed phasic dopamine changes varies several thousand fold, which offers a means to differentiate the behavioral relationships according to their time courses. Thus dopamine is involved in mediating the reactivity of the organism to the environment at different time scales, from fast impulse responses related to reward via slower changes with uncertainty, punishment, and possibly movement to the tonic enabling of postsynaptic motor, cognitive, and motivational systems deficient in Parkinson's disease.
Opening the door to the law : the law (2009)

The subject of legal pro bono work in this country is a topic rightly attracting increasing attention. The Cape Law Society requires its practising members to perform 24 hours of pro bono work each year. The scorecard of the draft Legal Services Sector Charter provides for the performance by attorneys of 24 hours of pro bono work per year or the performance of pro bono work in terms of the relevant statutory law society programme. And now the Law Society of the Northern Provinces is headed towards introducing a compulsory pro bono scheme for its practising members.
Low power duty cycle adjustment simple method in high speed serial links (2015)

A low power method of clock signal duty cycle adjustment is presented in this paper. The proposed architecture produces a synchronous signal in the output of system with 50±1% duty cycle over PVT, which is needed to avoid data error and setup/hold time margins violations during farther operation with data. Method also helps to improve noise immunity, because in case of 50% duty cycle signal in the input of synchronous system makes it more noise protected and helps to avoid phase errors between control signals. The presented correction mechanism can be used in the special input/output circuits of several standards such as Peripheral Component Interconnect (PCI), Universal Serial Bus (USB) and some structures of ADC/DACs.
A Method for Controlled Fault Interruption for Use with HV SF<inf>6</inf> Circuit Breakers (2007)

A method has been developed for synchronizing the trip commands to a HV circuit breaker in order to achieve a preselected optimum arcing time, even under transient asymmetrical fault current conditions. The algorithm estimates parameters of the fault current by applying least means squares regression to a generic model and sampled values of the current in each phase. An analysis of variance is made between the sampled and modeled currents to provide additional control and as a basis for discrimination between grounded and ungrounded fault cases. In addition, high power experiments have been conducted to investigate the stability of minimum arcing times of HV SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> circuit breakers over a large succession of interruptions. The data from these experiments indicates good stability in the minimum arcing time behavior, thus providing important information for the viability of synchronizing circuit breakers in order to avoid unnecessarily long arcing times.
<i>I</i> <i>n</i> <i>s</i> <i>i</i> <i>t</i> <i>u</i> observation of lamp zone melting of Si films on patterned SiO2 (1986)

Using video recording equipment we are able to visualize and study both the melting and freezing interfaces in lamp zone melting recrystallization of silicon on insulator (SOI) films. A so-called ‘‘explosive’’ melting has been observed, corresponding to a noncontinuous advance of the front. We also show the effectiveness of an etched pattern in the underlying SiO2 on the modulation of the solidification front. We thereby confirm the entrainment effect of this pattern. We observe then the effect of the scan speed on the liquid/solid interface morphology together with the entrainment efficiency.
Comparative Study of Powder Carriers Physical and Structural Properties (2022)

High specific surface area (SSA), porous structure, and suitable technological characteristics (flow, compressibility) predetermine powder carriers to be used in pharmaceutical technology, especially in the formulation of liquisolid systems (LSS) and solid self-emulsifying delivery systems (s-SEDDS). Besides widely used microcrystalline cellulose, other promising materials include magnesium aluminometasilicates, mesoporous silicates, and silica aerogels. Clay minerals with laminar or fibrous internal structures also provide suitable properties for liquid drug incorporation. This work aimed at a comparison of 14 carriers' main properties. Cellulose derivatives, silica, silicates, and clay minerals were evaluated for flow properties, shear cell experiments, SSA, hygroscopicity, pH, particle size, and SEM. The most promising materials were magnesium aluminometasilicates, specifically Neusilin<sup>®</sup> US2, due to its proper flow, large SSA, etc. Innovative materials such as FujiSil<sup>®</sup> or Syloid<sup>®</sup> XDP 3050 were for their properties evaluated as suitable. The obtained data can help choose a suitable carrier for formulations where the liquid phase is incorporated into the solid dosage form. All measurements were conducted by the same methodology and under the same conditions, allowing a seamless comparison of property evaluation between carriers, for which available company or scientific sources do not qualify due to different measurements, conditions, instrumentation, etc.
Augmented Reality: A Brand New Challenge for the Assessment and Treatment of Psychological Disorders (2015)

Augmented Reality is a new technological system that allows introducing virtual contents in the real world in order to run in the same representation and, in real time, enhancing the user's sensory perception of reality. From another point of view, Augmented Reality can be defined as a set of techniques and tools that add information to the physical reality. To date, Augmented Reality has been used in many fields, such as medicine, entertainment, maintenance, architecture, education, and cognitive and motor rehabilitation but very few studies and applications of AR exist in clinical psychology. In the treatment of psychological disorders, Augmented Reality has given preliminary evidence to be a useful tool due to its adaptability to the patient needs and therapeutic purposes and interactivity. Another relevant factor is the quality of the user's experience in the Augmented Reality system determined from emotional engagement and sense of presence. This experience could increase the AR ecological validity in the treatment of psychological disorders. This paper reviews the recent studies on the use of Augmented Reality in the evaluation and treatment of psychological disorders, focusing on current uses of this technology and on the specific features that delineate Augmented Reality a new technique useful for psychology.
Advances in Human Action Recognition: A Survey (2015)

Human action recognition has been an important topic in computer vision due to its many applications such as video surveillance, human machine interaction and video retrieval. One core problem behind these applications is automatically recognizing low-level actions and high-level activities of interest. The former is usually the basis for the latter. This survey gives an overview of the most recent advances in human action recognition during the past several years, following a well-formed taxonomy proposed by a previous survey. From this state-of-the-art survey, researchers can view a panorama of progress in this area for future research.
Transplantation and inflammation: implications for the modification of chemokine function (2014)

Oxidative stress is a major and recurring cause of damage during inflammation, especially following organ transplantation. Initial ischaemia-reperfusion injury causes the production of many reactive oxygen and nitrogen species, and subsequent recruitment and activation of inflammatory cells can lead to further oxidative stress. This stress is well known to cause damage at the cellular level, for example by induction of senescence leading to the production of a characteristic senescence-associated secretory phenotype. Chemokines are an important component of the senescence-associated secretory phenotype, recruiting further leucocytes and reinforcing the stress and senescence responses. As well as inducing the production of proteins, including chemokines, oxidative stress can alter proteins themselves, both directly and by induction of enzymes capable of modification. These alterations can lead to important modifications to their biological activity and also alter detection by some antibodies, potentially limiting the biological relevance of some immunochemical and proteomic biomarkers. Peroxynitrite, a reactive nitrogen species generated during inflammation and ischaemia, can cause such modifications by nitrating chemokines. Matrix metalloproteinases, released by many stressed cells, can cleave chemokines, altering function, while peptidylarginine deiminases can inactivate certain chemokines by citrullination. This review discusses the relationship between inflammation and post-translational modification, focusing on the functional modulation of transplant-relevant pro-inflammatory chemokines.
Aluminum levels in brain in Alzheimer's disease. (1978)

Dit artikel heeft als ondeiWerp functionele gegevensmodellen. In de inleiding wordt geschetst wat de plaats van deze modellen is binnen het kader van gegevensmodellen. Functionele modellen hebben een belangrijke rol gespeeld bij de ontwikkeling van gegevensmodellen. Een aantal concepten, die binnen het kader van de functionele modellen zijn onderzocht, zijn terug te vinden in latere modellen,\nzoals de object-georienteerde modellen.\nNaast de basisingredienten van functionele modellen, die besproken worden aan de hand van het functionele model van Shipman [28], wordt ingegaan op een aantal toepassingen die de mogelijkheden van functionele modellen illustreren. Een aantal ontwikkelingen rond de functionele modellen wordt besproken.
Role of rel family genes in normal and malignant lymphoid cell growth. (1992)

The rel family of genes encodes transcription factors, such as the v-rel oncoprotein and cellular transcription complexes (eg NF-kappa B), consisting of c-rel and related polypeptides. The expression of these genes is correlated most closely with lymphoid cell differentiation and growth stimulation in a variety of cell types. Similarly, rel family proteins control a number of genes involved in lymphoid cell growth and differentiation. Thus, it is not surprising that mutations in rel genes have been implicated directly and circumstantially in a number of lymphoid malignancies, as have a number of other cellular and viral transcription factors (see also Cleary M, Hayman M and Beug H, this issue and reviewed in Rabbitts, 1991). In addition, rel proteins are likely to be involved in T cell diseases caused by the human retroviruses HTLV-I and HIV-1. Therefore, rel proteins could serve as targets for anti-viral or anti-cancer therapies.
Design dependent process monitoring for back-end manufacturing cost reduction (2010)

Short-loop process monitoring structures (usually simple device I — V, C — V measurements made after M1 fabrication) are commonly put in wafer scribe-lines. These test structures are almost always design independent and measured/monitored by the foundry to keep track of process deviations. We propose a design-dependent process monitoring strategy which can accurately predict design performance based on simple I eff -based delay and I off -based leakage power estimates. We show that our strategy works much better (0.99 correlation vs. 0.87) compared to conventional design-independent monitors. Further, we use the predicted delay and leakage power for early yield estimation for pruning bad wafers to save test and back-end manufacturing costs We show that wafer pruning based on our approach can achieve upto 98% of the maximum achievable benefit/profit. We design the measurement and prediction schemes so as to minimize data as well as computation that needs to be kept track of during wafer fabrication. Such design-dependent process monitoring can help target process control/optimization effort, enable quicker yield ramp besides saving test and manufacturing costs.
Increased risk of myelotoxicity in elderly patients with non‐Hodgkin lymphoma (2003)

Neutropenia is the major dose‐limiting toxicity of myelosuppressive chemotherapy in patients with cancer. Because of the high incidence of neutropenic complications and death in the early cycles of chemotherapy and the potential for improved outcomes, prophylaxis with colony‐stimulating factor beginning in the first cycle should be routinely considered in elderly patients with non‐Hodgkin lymphoma who are treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP‐like chemotherapy regimens.