gebhart/patrepeval huggingface dataset:
Video Registration in Egocentric Vision under Day and Night Illumination Changes (2016)

With the spread of wearable devices and head mounted cameras, a wide range of application requiring precise user localization is now possible. In this paper we propose to treat the problem of obtaining the user position with respect to a known environment as a video registration problem. Video registration, i.e. the task of aligning an input video sequence to a pre-built 3D model, relies on a matching process of local keypoints extracted on the query sequence to a 3D point cloud. The overall registration performance is strictly tied to the actual quality of this 2D-3D matching, and can degrade if environmental conditions such as steep changes in lighting like the ones between day and night occur. To effectively register an egocentric video sequence under these conditions, we propose to tackle the source of the problem: the matching process. To overcome the shortcomings of standard matching techniques, we introduce a novel embedding space that allows us to obtain robust matches by jointly taking into account local descriptors, their spatial arrangement and their temporal robustness. The proposal is evaluated using unconstrained egocentric video sequences both in terms of matching quality and resulting registration performance using different 3D models of historical landmarks. The results show that the proposed method can outperform state of the art registration algorithms, in particular when dealing with the challenges of night and day sequences.
Methylation status of BCRP detected by methylation-specific PCR is inversely correlated with its expression and drug resistance in vitro and in patients with cancers (2006)

1 Breast cancer resistant protein (BCRP) functions as a drug efflux transporter that mediates drug resistance. Topoisomerase I inhibitors including SN-38 (an active metabolite of irinotecan) are substrates effluxed by BCRP. The underlying mechanisms for overexpression of BCRP during acquisition of drug resistance remain unclear. The aims of this study are to examine a correlation of altered methylation status in the promoter region of BCRP with BCRP expression and drug resistance in lung and colorectal cancers, and to establish a methylation-specific PCR (MSP) method for BCRP. Treatment of non-BCRP-expressing PC-6 cells with DNA methyltransferase inhibitor, 5-aza-2′-deoxycytidine, induced BCRP re-expression at the mRNA and protein levels. Bisulfite sequencing analysis and subsequent comparisons between bisulfite-modified and unmodified DNA sequences at CpG sites in the promoter region of BCRP (spanning from nt -1381 to +261) revealed that both alleles at all 89 CpG sites were completely methylated in PC-6, while those at 79 CpG sites (at nt -720 to +261) in BCRP-expressing cells of PC-6/SN2-5H were unmethylated. These results indicate a correlation between demethylation of the promoter region of BCRP and BCRP re-expression, and suggest a mechanism for SN-38 drug resistance. Analysis using MSP we developed also revealed an inverse correlation between methylation status of the promoter region of BCRP and BCRP mRNA expression in several lung and colorectal cancers. Examination of methylation status of the promoter region of BCRP using MSP before chemotherapy may provide a new biomarker for predicting drug resistance and responsibility.
Development of Superconducting Insertion Device Magnets at NSRRC (2007)

A superconducting wavelength shifter (SWLS) with a magnetic field of 6.5 T in cryogen‐free operation provides X‐rays for high‐resolution X‐ray microscopy, EXAFS, and medical imaging beamlines. A 32‐pole superconducting wiggler (SW) with a period of 6.1 cm and a magnetic field of 3.2 T in a liquid helium bath provides for three dedicated protein crystallography beamlines. Additionally, three 16‐pole in‐achromatic superconducting wigglers (IASW) with a period of 6.1 cm and a field strength of 3.1 T were constructed in‐house and installed between the first and second bending magnets of a TBA arc section. Development of a prototype superconducting undulator (SU15) with a period of 15 mm and a field strength of 1.4 T is currently underway at National Synchrotron Radiation Research Center (MSRRC).
Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex. (1976)

The role of the products of the K and D loci of the H-2 complex as target antigens for cytotoxic T cells generated to modified syngeneic cells has been investigated. Spleen cells, when cocultured with trinitrophenyl-derivatized syngeneic cells, generate cytolytic T cells that lyse most effectively tumor or spleen targets that are trinitrophenyl-derivatized and H-2 identical to the sensitizing cell. Cytolysis is inhibited by alloantisera to the K and/or D specificities of the target cells and by anti-dinitrophenyl antisera. Cytolic cells generated in this manner are also able to lyse, though less efficiently, trinitrophenyl-derivatized tumor and spleen targets that do not share products of the K and D loci with the sensitizing cell, and this cytolysis is also blocked by alloantisera directed to the H-2 serological specificities of such targets.
OS0206 Effects of electric field and poling on the response of multilayer piezoelectric film actuators with partial electrodes (2008)

This paper describes the results of our numerical and experimental studies of the electromechanical field concentrations due to surface and internal electrodes in partially poled multilayer piezoelectric film actuators under electric fields. A nonlinear finite element analysis is performed to predict the polarization switching zone and to discuss the electromechanical fields. Displacement versus voltage curves are also measured to validate the numerical predictions, and comparisons are made between numerical results and experimental data. Moreover, the results of the partially poled multilayer actuators are compared with those of fully poled actuators.
Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL (2003)

Childhood acute lymphoblastic leukemia (ALL) is often associated with extramedullary infiltration by leukemic cells at diagnosis or at relapse. To understand the mechanisms behind the dissemination of T-cell ALL (T-ALL) cells this study investigated the homing receptor expression on the blast cells of 11 pediatric T-ALL patients at diagnosis. One patient revealed a unique profile with high expression of the chemokine receptor CCR9 and the integrin CD103 on the T-ALL cells. Both of these molecules are specifically associated with homing to the gut. This finding was clinically significant as the patient later suffered a relapse that was confined to the gut. Immunohistochemistry revealed that the leukemic cells in the gut still expressed CCR9 and colocalized with a high expression of the CCR9 ligand, CCL25. These findings suggest that the original expression of CCR9 and CD103 on the leukemic cells contributed to the relapse location in the gut of this patient.
Experimental methods of ethanol administration (1989)

Techniques are reviewed for the experimental feeding of alcohol, including a liquid diet procedure invented 25 years ago. This technique results in much higher ethanol intake than with other approaches. As a consequence, various complications observed in alcoholics can be reproduced in animal models. These include fatty liver, hyperlipemia, various metabolic and endocrine disorders, tolerance to ethanol and other drugs, physical dependence and withdrawal and, in the baboon, liver fibrosis and cirrhosis. Variations of the liquid diet formulation are compared, and adequacy of nutrition in terms of minerals, vitamins, lipotropes, carbohydrates and proteins is discussed. The importance of selecting proper controls is emphasized. The respective advantages of three standardized basic rat formulas are reviewed: (i) an all-purpose (35% fat) diet, comparable to the diet previously referred to as the "Lieber-DeCarli formula" and suitable for most experimental applications, particularly those intended to mimic the clinical situation in which the various effects of alcohol occur in the setting of hepatic changes characterized by a fatty liver; (ii) a low-fat diet comparable in all respects to the preceding diet but with a lower fat content, intended to minimize the hepatic changes, and (iii) a high-protein formula particularly useful in those circumstances in which an oversupply of dietary protein might be recommended (i.e. pregnancy). Variations of this technique, including continuous intragastric infusion, are also discussed. It is concluded that, for most experimental studies of chronic alcohol consumption, the liquid diet technique provides one of the most efficient tools to study the effects of ethanol under controlled nutritional conditions because it allows for alcohol consumption of clinical relevance and offers flexibility to adjust to special experimental or physiologic needs by allowing for various substitutions required for a particular experimental design, including changes in lipids, proteins or other dietary constituents. The technique also facilitates the comparison with controls by simplifying the pair feeding and is the best procedure available for the study of the toxic effects of alcohol and their interactions with deficiency or excess of various nutrients.
Energetic studies on DNA–peptide interaction in relation to the enthalpy–entropy compensation paradox (2012)

This study aims to interpret the energetic basis of complex DNA-peptide interactions according to a novel allosteric interaction network approach. In common with other designed peptides, five new conjugates incorporating the XPRK or XHypRK motif (Hyp = hydroxyproline) attached to a N-methylpyrrole (Py) tract with a basic tail have been found to display cooperative binding to DNA involving multiple monodentate as well as interstrand bidentate interactions. Using quantitative DNase I footprinting it appears that allosteric communication via cooperative binding to multiple sites on complementary DNA strands corresponds to two different types of DNA-peptide interaction network. Temperature variation experiments using a dodecapeptide RY-12 show that lower temperature (25 °C) favor a circuit type of allosteric interaction network, whereas higher temperatures (31 and 37 °C) afford only a partial-circuit type of network. Circular dichroism studies show that our five peptides induce significant local conformational changes in DNA via the minor groove, with apparently dimeric binding stoichiometry. Isothermal titration calorimetry reveals that these peptides, together with another seven for comparison, are strongly exothermic upon binding to a model 13-mer DNA duplex, characterized by ΔH ranging from -14.7 to -74.4 kcal mol(-1), and also high TΔS ranging from -6.5 to -65.9 kcal mol(-1). Multiple monodentate and bidentate interactions, as well as ionic forces that mediate positive cooperativity in sequence recognition, are consistent with a dramatic decrease in entropy and a 'tightening' effect of DNA conformation. Distinctive enthalpy-entropy compensation (EEC) relationships are demonstrated for the interaction of all twelve designed peptides with DNA, affording a straight line of slope close to unity when ΔH is plotted versus TΔS, with a y-axis intercept (average ΔG) corresponding to -8.5 kcal mol(-1), while the observed ΔG ranges from -8.2 to -9.1 kcal mol(-1) for the peptides. The EEC seen with peptide RY-12 binding to the model duplex persists throughout various incubation temperatures. The net compensation of energy between the favorable negative ΔH and unfavorable negative ΔS components thus constrains the value of net binding free energy ΔG within a remarkably constant range, as is clearly visible in a 3-dimensional energetic plot. We conclude that the preservation of a rather narrowly-defined ΔG value is central to the EEC in DNA-peptide interactions, illuminating the universal EEC paradox commonly found in diverse biochemical reactions.
Mechanisms of impact head injury (1994)

A review of research on brain trauma mechanisms operative during head impact is presented from a clinically relevant biomechanical perspective. Emphasis is placed on microscopic mechanisms, gleaned from isolated neural tissue and cellular biomechanisms research, and their relation to macro sale mechanisms observed in head injury victims and in experimental physical model experiments. Experimental and clinico-pathologic research, past and ongoing, substantiating the centripetal theory for concussive brain injury is also reviewed in the context of recent advancements in computations biomechanics of head injury brought about by the expanding availability of high speed super computers and brain imaging. A synopsis of our current computational research activities in head impact simulation is presented and some preliminary results are cited.
Molecular Modeling of Inhibitors at Q <sub>i</sub> and Q <sub>o</sub> Sites in Cytochrome <i>bc</i> <sub>1</sub> Complex (2002)

This chapter contains sections titled: Introduction The ‘Q-cycle’ mechanism Inhibitors of the Cytochrome bc1 Complex MOA and Related Qo Inhibitors Stigmatellin Antimycin Structure of the Cytochrome bc1 Complex Cytochrome b Cytochrome c1 “Rieske” iron sulfur protein Movement of the catalytic domain of the “Rieske” protein Phospholipids Quinone and Inhibitor Binding Sites The Qi binding site The Qo binding site Molecular Basis of Inhibitor Resistance Structural Basis of QoI Resistance Mutation Gly143Ala Mutation Phe129Leu Molecular Modeling of the Qo Binding Site Setting up of the system Modeling of the Qo site of Mycosphaerella fijiensis Calculation of Binding Constants Acknowledgements References
The N-Terminal Domain of OmpATb Is Required for Membrane Translocation and Pore-Forming Activity in Mycobacteria (2007)

OmpATb is the prototype of a new family of porins in Mycobacterium tuberculosis and Mycobacterium bovis BCG. Although the pore-forming activity of this protein has been clearly established by using recombinant protein produced in Escherichia coli, characterization of the native porin has been hampered by the scarce amount of protein present in the M. tuberculosis detergent extracts. To this aim, we have developed a protocol to overproduce and obtain high yields of OmpATb in both Mycobacterium smegmatis and M. bovis BCG. The protein could be extracted and purified from the cell wall fraction and subsequently used for analysis of the pore-forming activity in multichannel and single-channel conductance experiments. Our results indicate that OmpATb produced in mycobacteria presents an average conductance value of 1,600+/-100 pS, slightly higher than that of OmpATb produced in E. coli, suggesting the occurrence of OmpATb in a highly ordered organization within the mycobacterial cell wall. In contrast to OmpATb, a truncated form lacking the first 72 amino acids (OmpATb73-326) was essentially found in the cytosol and was not active in planar lipid bilayers. This suggested that the N-terminal domain of OmpATb could participate in targeting of OmpATb to the cell wall. This was further confirmed by analyzing M. smegmatis clones expressing a chimeric protein consisting of a fusion between the N-terminal domain of OmpATb and the E. coli PhoA reporter. The present study shows for the first time that the N terminus of OmpATb is required for targeting the porin to the cell wall and also appears to be essential for its pore-forming activity.
Effects of a Side Chain Aromatic Ring on the Reactivity of Copper(I) Complexes with Dioxygen (2001)

Stabilization of the bis(μ-oxo)dicopper(III) intermediate is achieved by using a bidentate N-donor ligand with pendent indole rings: N,N-bis[(3-indolyl)methyl]-N-[(2′-pyridyl)methyl]amine (BIP). The intermediate decomposes to give products arising from N-dealkylation and a product with a spiro ring composed of two indole rings (see scheme). This latter product probably results from a radical-coupling reaction.
Phase-based FBG detectors for self-diagnosis of marine vehicles structures (2011)

In the context of a new project named SEALAB, aimed at conceiving an innovative high speed marine vehicle, a new system for monitoring the structural response and potential damages in the ship structures is under development. This system permits the real-time self-monitoring of the structure using a new system of sensor based on optical fibers equipped with FBG (fiber-Bragg-gratings) sensors. These fibers are applied using different technologies. For traditional materials, like aluminum made structures, the fibers are simply glued along the system. For composite materials, the fibers are embedded directly into the matrix. A novel HHT-based method (Hilbert-Huang transform) for damage detection of panel structures under impulsive or travelling load is proposed. The technique is able to identify the presence and the location of the damage along the panels. The measured data are processed by the HHT technique, and none a priori information is needed about the response of the undamaged structure. Damage location is revealed by direct inspection of the first instantaneous frequency, which presents a sharp crest in correspondence of the damaged section.
Il-1β and Reactive Oxygen Species Differentially Regulate Neutrophil Directional Migration and Basal Random Motility in a Zebrafish Injury–Induced Inflammation Model (2014)

During inflammation, the proper inflammatory infiltration of neutrophils is crucial for the host to fight against infections and remove damaged cells and detrimental substances. IL-1β and NADPH oxidase-mediated reactive oxygen species (ROS) have been implicated to play important roles in this process. However, the cellular and molecular basis underlying the actions of IL-1β and ROS and their relationship during inflammatory response remains undefined. In this study, we use the zebrafish model to investigate these issues. We find that, similar to that of NADPH oxidase-mediated ROS signaling, the Il-1β-Myd88 pathway is required for the recruitment of neutrophils, but not macrophages, to the injury-induced inflammatory site, whereas it is dispensable for bacterial-induced inflammation. Interestingly, the Il-1β-Myd88 pathway is independent of NADPH oxidase-mediated ROS signaling and critical for the directional migration, but not the basal random movement, of neutrophils. In contrast, the NADPH oxidase-mediated ROS signaling is required for both basal random movement and directional migration of neutrophils. We further document that ectopic expression of Il-1β in zebrafish induces an inflammatory disorder, which can be suppressed by anti-inflammatory treatment. Our findings reveal that the Il-1β-Myd88 axis and NADPH oxidase-mediated ROS signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation. In addition, Il-1β overexpressing Tg(hsp70:(m)il-1β_eGFP;lyz:DsRed2)hkz10t;nz50 transgenic zebrafish provides a useful animal model for the study of chronic inflammatory disorder and for anti-inflammatory drug discovery.
ESR studies of chemically dehydrofluorinated poly(vinylidene fluoride) (2008)

X-band ESR of chemically dehydrofluorinated poly(vinylidene fluoride) films has been studied in the 150 ÷ 375 K temperature range. Dehydrofluorinated films reveal an ESR signal with g-factor close to that of the free electron. The ESR parameters (integral intensity, width, g-factor) of the samples depend on duration of the chemical reaction, storage conditions and temperature. Heating above 375 K modifies paramagnetic component of the samples stored in air irreversibly, probably, as a result of hydrogenous radicals desorption and/or removal of oxygen, hydroxyl groups and moisture from the samples on heating. The deviation from the Curie law has been revealed for all the investigated samples.
Statistics on Logic Simulation (1986)

The high costs associated with logic simulation of large VLSI based systems have led to the need for new computer architectures tailored to the simulation task. Such architectures have the potential for significant speedups over standard software based logic simulators. Several commercial simulation engines have been produced to satisfy needs in this area. To properly explore the space of alternative simulation architectures, data is required on the simulation process itself. This paper presents a framework for such data gathering activity by first examining possible sources of speedup in the logic simulation task, examining the sort of data needed in the design of simulation engines, and then presenting such data. The data contained in the paper includes information on subtask times found in standard discrete event simulation algorithms, event intensities, queue length distributions and simultaneous event distributions.
New Potential Hazard Regarding Use of Marijuana – Treatment of Plants with Liquid Fertilizers (1976)

(1976). New Potential Hazard Regarding Use of Marijuana – Treatment of Plants with Liquid Fertilizers. Journal of Psychedelic Drugs: Vol. 8, No. 2, pp. 151-155.
Learning dynamics in social dilemmas (2002)

The Nash equilibrium, the main solution concept in analytical game theory, cannot make precise predictions about the outcome of repeated mixed-motive games. Nor can it tell us much about the dynamics by which a population of players moves from one equilibrium to another. These limitations, along with concerns about the cognitive demands of forward-looking rationality, have motivated efforts to explore backward-looking alternatives to analytical game theory. Most of the effort has been invested in evolutionary models of population dynamics. We shift attention to a learning-theoretic alternative. Computational experiments with adaptive agents identify a fundamental solution concept for social dilemmas--stochastic collusion--based on a random walk from a self-limiting noncooperative equilibrium into a self-reinforcing cooperative equilibrium. However, we show that this solution is viable only within a narrow range of aspiration levels. Below the lower threshold, agents are pulled into a deficient equilibrium that is a stronger attractor than mutual cooperation. Above the upper threshold, agents are dissatisfied with mutual cooperation. Aspirations that adapt with experience (producing habituation to stimuli) do not gravitate into the window of viability; rather, they are the worst of both worlds. Habituation destabilizes cooperation and stabilizes defection. Results from the two-person problem suggest that applications to multiplex and embedded relationships will yield unexpected insights into the global dynamics of cooperation in social dilemmas.
Studies on the Mechanical Properties, Workability and Heat Treatment of Ti-Fe-Al Alloy (1955)

By means of consumable double melting method we produced a titanium ingot containing about 2% each of iron and aluminium, whose structure is uniform and sound. As to mechanical properties, its tensile strength and elongation are about 90 kg/mm2 and 20% at room temperature, respectively, and consequently this product shows a satisfactory result as high tensile alloy. Its tensile strength and elongation at 600° rise to 30 kg/mm2 and 30%,respectively, and at moderate temperature it shows excellent heat resistance.As to workability, it is easily subjected to hot forging and rolling. Furthermore, even in the case of 50% reduction by cold rolling it can obtain the tensile strength of 130 kg/mm2, and in the case of reduction up to 80% by cold drawing the tensile strength becomes 150 kg/mm2. With regard to heat treatment property, it shows a structure of α+β at room temperature, and in the case of water quenching from the temperature of 1,000° it shows the structure of α′. As a result of isothermal transformation test at the temperature ranging from 400° to 950°, α structure appears in the quanching structure, while in quench aging test an unknown precipitation appears in the structure at the temperature of about 500°.