gebhart/patrepeval huggingface dataset:
EFFECT OF A RETICULOENDOTHELIAL STIMULATING AGENT (RESTIM) ON RESISTANCE OF MICE (1962)

Ransom, John P. (New England Institute for Medical Research, Ridgefield, Conn.), Varsenig Z. Pasternak, and John H. Heller. Effect of a reticuloendothelial stimulating agent (restim) on resistance of mice. J. Bacteriol. 84:466-472. 1962.-The effect of restim, a preparation of yeast cell walls, on resistance of mice to challenge by Salmonella typhimurium has been investigated. Although restim markedly increases the rate of phagocytosis and clearance of carbon particles, and presumably of viable bacterial cells, this activity has no significant effect on the course of events when restim-treated mice are challenged with S. typhimurium. However, when specific antibody derived from either active or passive immunization of the mice is present, restim significantly enhances resistance as judged by survival time and by 20-day survival.
The agmR gene, an environmentally responsive gene, complements defective glpR, which encodes the putative activator for glycerol metabolism in Pseudomonas aeruginosa (1991)

The genes for the peripheral glycerol carbon metabolic pathway (glp) in Pseudomonas aeruginosa are postulated to be positively regulated by GlpR. A gene complementing the glpR2 allele, affecting expression of the putative activator, was cloned by a bacteriophage mini-D3112-based in vivo cloning method. Mini-D3112 replicons were isolated by transfecting glpR2 strain PRP406 and selecting clones able to grow on minimal medium containing glycerol as the sole carbon and energy source. Preliminary biochemical characterization indicated that the cloned activator gene for glycerol metabolism (agmR) may not be allelic to glpR. Restriction analysis and recloning of DNA fragments located the agmR gene to a 2.3-kb EcoRV-SstI DNA fragment. In a T7 RNA polymerase expression system, a single 26,000-Da protein was expressed from this DNA fragment. The amino acid sequence of this protein, deduced from the nucleotide sequence reported here, demonstrates its homology to the effector (or regulator) proteins of the environmentally responsive two-component regulators. The carboxy-terminal region of AgmR contains a possible helix-turn-helix DNA-binding motif and resembles sequences found in transcriptional regulators of the LuxR family.
Normalized Outputs to Turbulent Boundary Layer (TBL) of Pressure and Velocity Transducers and Their Sensitivities (2000)

Two recent reports addressed the wavevector-frequency spectral density of a turbulent boundary layer (TBL) and the manner by which the filtering efficiencies of the boundaries, blankets, transducers and arrays challenge this spectral density. Whereas the goal of a design is to maintain largely intact the output to a signal (a supersonic incident pressure field), the output to a (TBL) must be largely subdued; i.e., a component in the (TBL) must be largely rejected from inducing an output in the transducer. The rejection of (TBL) that can be mustered by a flush-mounted pressure transducer and by a flush-mounted velocity transducer are compared in these reports. In this report the comparison is extended to transducer configurations that are not merely designated flush-mounted. Also, the comparison is made not just on the raw basis of the wavevector-frequency filtering efficiencies and the wavevector-frequency spectral density of (TBL), but, in addition, by evaluating the frequency spectral densities registered by the two sets of transducers. The frequency spectral densities are quantities that are more commensurate with the outputs of actual transducers and arrays. However, the evaluation of the frequency spectral densities provide for more specific assessments than those afforded by consideration of the wavevector-frequency spectral densities. In this sense, this report sacrifices generality in an attempt to render the material discussed in the two referenced reports more akin in format to the kind of information that is usually requested by designers of naval sonar systems.
Antibody response of brown trout Salmo trutta injected with pathogenic Saprolegnia parasitica antigenic extracts (2007)

Brown trout Salmo trutta injected with antigenic extracts from a pathogenic isolate of Saprolegnia parasitica developed specific antibodies that were detected by enzyme-linked immunosorbent assay (ELISA), immunofluorescence (IF) and Western blotting (WB), but not by immunodiffusion (ID). Three groups of five 2 yr old brown trout were injected intraperitoneally with 3 different antigenic extracts: small hyphal fragments (HF) and soluble extracts from sonicated mycelia grown in medium with or without beta-sytosterol (SEB and SE, respectively). In the 2 groups injected with SE and SEB, antibodies were found in 66.7 % of the serum samples by ELISA, 54.5% by IF and 48.5% by WB. In the group injected with HF, only 1 trout survived the experiment, and in this fish only 1 sample was positive by ELISA. The results obtained by ELISA and IF were similar and show that there is cross-reaction between the antigens used. By WB, the proteins most frequently recognised were 2 proteins of 25 and 29 kDa. No significant differences were found in the groups injected with SE or SEB.
Quantitative Sum-Frequency Generation Vibrational Spectroscopy of Molecular Surfaces and Interfaces: Lineshape, Polarization, and Orientation (2014)

Sum-frequency generation vibrational spectroscopy (SFG-VS) can provide detailed information and understanding of the molecular composition, interactions, and orientational and conformational structure of surfaces and interfaces through quantitative measurement and analysis. In this review, we present the current status of and discuss important recent developments in the measurement of intrinsic SFG spectral lineshapes and formulations for polarization measurements and orientational analysis of SFG-VS spectra. The focus of this review is to present a coherent description of SFG-VS and discuss the main concepts and issues that can help advance this technique as a quantitative analytical research tool for revealing the chemistry and physics of complex molecular surfaces and interfaces.
Kinetic Rates and Linear Free Energy Relationships for Water Dissociation on Transition and Noble Metal Dimers (2009)

A systematic study of the adsorption and dissociation of water on transition and noble metal dimers (Fe(2), Ru(2), Os(2), Co(2), Rh(2), Ir(2), Ni(2), Pd(2), Pt(2), Cu(2), Ag(2), Au(2)) is presented. Spin-unrestricted density functional theory simulations indicate that the dissociation (lysis) of water on these clusters may be thermally driven even in the absence of other electrocatalytically and photocatalytically driven processes. Two reaction pathways are found with turnover frequencies for water dissociation given by the following series: Co(2) > Ir(2) > Fe(2) > Rh(2) > Ni(2) > Pt(2) > Ru(2) > Os(2) > Cu(2) > Au(2) > Pd(2) > Ag(2) at standard ambient temperature and pressure. Linear free energy relationships are presented that can predict the dissociation barrier of water on transition and noble metals as a function of free energy change for dissociation.
Synthesis, photoluminescence and thermal quenching of YAG:Ce phosphor for white light emitting diodes (2011)

The synthesis route at low temperature for Ce-doped yttrium aluminium garnet (YAG:Ce) phosphor is described. Its photoluminescence efficiency and quenching temperature dependence characteristics are found to be comparable to the imported one. YAG:Ce shows least thermal quenching among the several blue LED phosphors [CaS:Eu 2+ , (Y,Gd) 3 Al 5 O 12 :Ce 3+ , SrS:Eu 2+ and SrGa 2 S 4 :Eu 2+ ].
Mathematical analysis of activation thresholds in enzyme-catalyzed positive feedbacks: application to the feedbacks of blood coagulation. (1995)

A hierarchy of enzyme-catalyzed positive feedback loops is examined by mathematical and numerical analysis. Four systems are described, from the simplest, in which an enzyme catalyzes its own formation from an inactive precursor, to the most complex, in which two sequential feedback loops act in a cascade. In the latter we also examine the function of a long-range feedback, in which the final enzyme produced in the second loop activates the initial step in the first loop. When the enzymes generated are subject to inhibition or inactivation, all four systems exhibit threshold properties akin to excitable systems like neuron firing. For those that are amenable to mathematical analysis, expressions are derived that relate the excitation threshold to the kinetics of enzyme generation and inhibition and the initial conditions. For the most complex system, it was expedient to employ numerical simulation to demonstrate threshold behavior, and in this case long-range feedback was seen to have two distinct effects. At sufficiently high catalytic rates, this feedback is capable of exciting an otherwise subthreshold system. At lower catalytic rates, where the long-range feedback does not significantly affect the threshold, it nonetheless has a major effect in potentiating the response above the threshold. In particular, oscillatory behavior observed in simulations of sequential feedback loops is abolished when a long-range feedback is present.
First Record of Giant Anteater (Xenarthra, Myrmecophagidae) in North America (1987)

A right metacarpal III represents the first North American record of the giant anteater (Myrmecophaga tridactyla). Recovered in northwestern Sonora, Mexico, with a rich vertebrate fauna of early Pleistocene (Irvingtonian) age, it belongs to a cohort of large mammals that dispersed from South America to North America along a savanna corridor. Presumably habitat and climatic changes have subsequently driven this mammalian family more than 3000 kilometers back into Central America from its former expansion into temperate North America.
Understanding retweeting behaviors in social networks (2010)

Retweeting is an important action (behavior) on Twitter, indicating the behavior that users re-post microblogs of their friends. While much work has been conducted for mining textual content that users generate or analyzing the social network structure, few publications systematically study the underlying mechanism of the retweeting behaviors. In this paper, we perform an interesting analysis for the problem on Twitter. We have found that almost 25.5% of the tweets posted by users are actually retweeted from friends' blog spaces. Our investigation unveils that for the retweet behaviors, some statistics still follows the power law distribution, while some others violate the state-of-the-art distribution for Web. Based on these important observations, we propose a factor graph model to predict users' retweeting behaviors. Experimental results on the Twitter data set show that our method can achieve a precision of 28.81% and recall of 37.33% for prediction of the retweet behaviors.
Towards Processing of Big Graphs: from Theory, Algorithm to System (Invited Talk) (2016)

Graphs are very important parts of Big Data and widely used for modelling complex structured data with a broad spectrum of applications such as bioinformatics, web search, social network, road network, etc. Over the last decade, tremendous research efforts have been devoted to many fundamental problems in managing and analysing graph data. In this talk, I will present some of our recent research efforts in processing big graphs including scalable processing theory and techniques, distributed computation, and system framework.
Structure chimique des aspergillomarasmines A et B (1965)

Abstract La structure chimique, ainsi que la configuration de deux phytotoxines isolées d' Aspergillus flavus oryzae : les aspergillomarasmines A (XXVI) et B (VII) (cette dernière étant identique à l'acide lycomarasmique) sont établies.
Application of Lateral Photovoltaic Effect to the Measurement of the Physical Quantities of<i>P</i>-<i>N</i>Junctions–Sheet Resistivity and Junction Conductance of N<sub>2</sub><sup>+</sup>Implanted Si (1976)

A new method of measuring the physical quantities of a thin film p-n junction such as the one formed by ion implantation has been developed; by means of this method difficulties of making reliable electrical contacts with thin layers and leakage currents which are often encountered when applying the bias voltage can be avoided. Lucovsky's theory for the lateral photovoltaic effect has been extended such that nonzero values for sheet resistivities of both p and n layers and a finite value for the length of the junction are taken into consideration, and the modified theory has been experimentally verified using p-Si samples implanted with N2+ at 8 keV. With the aid of the theory, sheet resistivities, junction conductances and some other physical quantities are obtained by analysing the measured lateral photovoltage (LPV). The use of the LPV method together with the ordinary one increases the reliability of the measurement.
Influence of silver nanoparticles in the luminescence efficiency of Pr3+-doped tellurite glasses (2007)

We studied the influence of silver nanoparticles (NPs) in the luminescence properties of TeO2–PbO–GeO2 glass doped with trivalent praseodymium (Pr3+) ions. The experiments were performed with samples containing different concentrations of NPs controlled by heat treatment of the glass. The enhancement of the Stokes luminescence with the increase of the NPs concentration was observed for samples excited at 454nm. The influence of the NPs on the frequency upconversion (anti-Stokes) emissions of Pr3+ under excitation at 520nm was also investigated. In this case, enhancement of the emissions around 460 and 486nm was observed and the excitation pathway is also discussed.
Interaction of Ro 17–2301 (AMA-1080) with <i>β</i>-Lactamases (1984)

Against a variety of beta-lactamases tested, mostly of chromosomal origin, Ro 17-2301 (AMA-1080) proved to be more stable than the new cephalosporins and thus resembles aztreonam. Against the beta-lactamases from Klebsiella oxytoca and Pseudomonas vulgaris, however, Ro 17-2301 proved to be much more stable than aztreonam. Enzymatic hydrolysis, performed with the K. oxytoca beta-lactamase, yielded a single compound, viz. the microbiologically inactive, ring-opened structure. Ro 17-2301 is a potent and progressive inhibitor of cephalosporinases found, e.g., in Enterobacter cloacae and other gram-negative organisms. The IC50 and Ki values, however, showed that the affinity for these enzymes is lower than that of aztreonam.
[Preparation of no-sugar huazhen granules]. (1997)

This article introduces the preperation, especially its technologies of spraying, drying and making grain of no-sugar Huazhen Granules (composed of Flos lonicerae, Radix Bupleuri, etc.). Ideal grain can be obtained, the capacity of taking can be reduced greatly.
The immunological response of calves after submucosal application of a live vaccine against parainfluenza-3- and adenovirus. (Brief report). (1975)

Using submucosal application of live attenuated vaccine against parainfluenza-3-virus and cattle adenovirus within the nasal opening, calves reacted with the formation of secretory (local) and serum antibodies of significantly higher titers than are received using subcutaneous application. The same vaccine induces interferon activity in the serum and nasal secretion after submucosal vaccination. Adenovirus antigen is a stronger interferon inducer than para-influenza-3-virus.
ConMem (2010)

Multicore technology is making concurrent programs increasingly pervasive. Unfortunately, it is difficult to deliver reliable concurrent programs, because of the huge and non-deterministic interleaving space. In reality, without the resources to thoroughly check the interleaving space, critical concurrency bugs can slip into production runs and cause failures in the field. Approaches to making the best use of the limited resources and exposing severe concurrency bugs before software release would be desirable. Unlike previous work that focuses on bugs caused by specific interleavings (e.g., races and atomicity-violations), this paper targets concurrency bugs that result in one type of severe effects: program crashes. Our study of the error-propagation process of realworld concurrency bugs reveals a common pattern (50% in our non-deadlock concurrency bug set) that is highly correlated with program crashes. We call this pattern concurrency-memory bugs: buggy interleavings directly cause memory bugs (NULL-pointer-dereference, dangling-pointer, buffer-overflow, uninitialized-read) on shared memory objects. Guided by this study, we built ConMem to monitor program execution, analyze memory accesses and synchronizations, and predicatively detect these common and severe concurrency-memory bugs. We also built a validator ConMem-v to automatically prune false positives by enforcing potential bug-triggering interleavings. We evaluated ConMem using 7 open-source programs with 9 real-world severe concurrency bugs. ConMem detects more tested bugs (8 out of 9 bugs) than a lock-set-based race detector and an unserializable-interleaving detector that detect 4 and 5 bugs respectively, with a false positive rate about one tenth of the compared tools. ConMem-v further prunes out all the false positives. ConMem has reasonable overhead suitable for development usage.
New methods for alkaloid synthesis: .alpha.-acylamino radical cyclizations (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew methods for alkaloid synthesis: .alpha.-acylamino radical cyclizationsDavid J. Hart and Yeun-Min TsaiCite this: J. Am. Chem. Soc. 1982, 104, 5, 1430–1432Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/ja00369a050https://doi.org/10.1021/ja00369a050research-articleACS PublicationsRequest reuse permissionsArticle Views506Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Performance Benefits for Wave Rotor-Topped Gas Turbine Engines (1996)

The benefits of wave rotor-topping in turboshaft engines, subsonic high-bypass turbofan engines, auxiliary power units, and ground power units are evaluated. The thermodynamic cycle performance is modeled using a one-dimensional steady-state code; wave rotor performance is modeled using one-dimensional design/analysis codes. Design and off-design engine performance is calculated for baseline engines and wave rotor-topped engines, where the wave rotor acts as a high pressure spool. The wave rotor-enhanced engines are shown to have benefits in specific power and specific fuel flow over the baseline engines without increasing turbine inlet temperature. The off-design steady-state behavior of a wave rotor-topped engine is shown to be similar to a conventional engine. Mission studies are performed to quantify aircraft performance benefits for various wave rotor cycle and weight parameters. Gas turbine engine cycles most likely to benefit from wave rotor-topping are identified. Issues of practical integration and the corresponding technical challenges with various engine types are discussed.
The Challenge of Language Assessment for African American English-Speaking Children: A Historical Perspective (2004)

The diagnostic problem of how validly to assess the language of children who speak dialects different from Mainstream American English (MAE) has challenged the field of communication disorders for several decades. The key to its solution is to recognize differences due to dialect or development and remove them from the initial diagnosis of a disorder. A new approach to the puzzle, implemented jointly by University of Massachusetts scholars and the Psychological Corporation (TPC), takes two directions: (1) it provides new normative data on African American English (AAE) development, and (2) it proposes a level of analysis deeper than dialect for the discovery of alternate markers of a disorder. We present three objectives for a language assessment instrument designed to solve this longstanding problem: (1) to answer the problem/no problem question for a given child; (2) to provide explanatory data about the nature of the problem; and (3) to achieve objectives 1 and 2 in a way that is culturally and linguistically fair to both speakers of MAE and speakers of other dialects of English such as AAE.
British food habits (1977)

Cucurbit[n]urils (CB[n]s) provide a class of macrocycles that are able to form stable host–guest complexes with various guests. A wide range of potential guests has stimulated an increasing number of fundamental molecular recognition studies that led to various biomolecular applications. The systems are intrinsically dynamic and can rearrange, while some of the interactions are reversible upon stimuli. We have discussed the origins of the molecular recognition properties of the CB[n] family and methods to gain control over the binding affinity to CB[n]. We have described the amino acid based recognition of CB[n] and subsequently review the literature on how these properties can be successfully employed to dynamically probe the properties and function of peptides, proteins and cells, which is important for bioanalytical and biomedical applications.
Systems-level characterization of a host-microbe metabolic symbiosis in the mammalian gut (2013)

The human gut microbiota consists of ten times more microorganisms than there are cells in our body, processes otherwise indigestible nutrients, and produces important energy precursors, essential amino acids, and vitamins. In this study, we assembled and validated a genome-scale metabolic reconstruction of Bacteroides thetaiotaomicron (iAH991), a prominent representative of the human gut microbiota, consisting of 1488 reactions, 1152 metabolites, and 991 genes. To create a comprehensive metabolic model of host-microbe interactions, we integrated iAH991 with a previously published mouse metabolic reconstruction, which was extended for intestinal transport and absorption reactions. The two metabolic models were linked through a joint compartment, the lumen, allowing metabolite exchange and providing a route for simulating different dietary regimes. The resulting model consists of 7239 reactions, 5164 metabolites, and 2769 genes. We simultaneously modeled growth of mouse and B. thetaiotaomicron on five different diets varying in fat, carbohydrate, and protein content. The integrated model captured mutually beneficial cross-feeding as well as competitive interactions. Furthermore, we identified metabolites that were exchanged between the two organisms, which were compared with published metabolomics data. This analysis resulted for the first time in a comprehensive description of the co-metabolism between a host and its commensal microbe. We also demonstrate in silico that the presence of B. thetaiotaomicron could rescue the growth phenotype of the host with an otherwise lethal enzymopathy and vice versa. This systems approach represents a powerful tool for modeling metabolic interactions between a gut microbe and its host in health and disease.