gebhart/patrepeval huggingface dataset:
Definition of microRNAs That Repress Expression of the Tumor Suppressor Gene <i>FOXO1</i> in Endometrial Cancer (2009)

Endometrial cancer is the most common malignancy of the lower female reproductive tract. The tumor suppressor FOXO1 is downregulated in endometrial cancer compared with normal endometrium but the underlying mechanisms are not well understood. Using microRNA (miR) target prediction algorithms, we identified several miRs that potentially bind the 3'-untranslated region of FOXO1 transcripts. Expression profiling of normal and malignant endometrial samples by quantitative real-time PCR and Northern blot analysis revealed an inverse correlation between the levels of FOXO1 protein and the abundance of several of the in silico-predicted miRs, suggesting that loss of FOXO1 expression in endometrial cancer may be mediated by miRs. To determine the role of candidate miRs, we used the endometrial cancer cell lines HEC-1B and Ishikawa, which express FOXO1 at high and low levels, respectively. Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1. Conversely, FOXO1 expression was efficiently restored in the Ishikawa cell line upon simultaneous inhibition of miR-9, miR-27, miR-96, miR-153, miR-183, and miR-186. Moreover, induction of FOXO1 in Ishikawa cells by miR inhibitors was accompanied by G1 cell cycle arrest and cell death, and was attenuated by the small interfering RNA-mediated downregulation of FOXO1 expression. Our findings identify several miRs overexpressed in endometrial cancer that function in concert to repress FOXO1 expression. Further, aberrant miR expression results in deregulated cell cycle control and impaired apoptotic responses, and thus, may be central to endometrial tumorigenesis.
Citrus Canker and Citrus Huanglongbing, two Exotic Bacterial Diseases Threatening the Citrus Industries of the Western Hemisphere (2007)

plaguing citrus industries in the Western Hemisphere. The two largest citrus producing areas in the Americas, located in Florida and the states of Sao Paulo, Parana and Minas Geris, Brazil, are presently battling these devastating diseases. The presence of these diseases in the Florida and Brazilian citrus industries also poses an imminent threat to other major citrus producing areas within the US, such as California, Texas, and Arizona and the important northern citrus producing areas in Argentina.
Fast and robust short video clip search using an index structure (2004)

In this paper, we present an index structure-based method to fast and robustly search short video clips in large video collections. First we temporally segment a given long video stream into overlapped matching windows, then map extracted features from the windows into points in a high dimensional feature space, and construct index structures for these feature points for querying process. Different from linear-scan similarity matching methods, querying process can be accelerated by spatial pruning brought by an index structure. A multi-resolution kd-tree (mrkd-tree) is employed to complete exact K-NN Query and range query with the aim of fast and precisely searching out all short video segments having the same contents as the query. In terms of feature representation, rather than selecting representative key frames, we develop a set of spatial-temporal features in order to globally capture the pattern of a short video clip (e.g. a commercial clip, a lead in/out clip) and combine it with the color range feature to form video signatures. Our experiments have shown the efficiency and effectiveness of the proposed method that the very first instance of a given 10-sec query clip can be identified from a 10.5-hour video collection in tens of milliseconds. The proposed method has been also compared with the fast sequential search algorithm
Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses (2010)

Our data show that Oct-6 expression is not as restricted as previously assumed. Induction of Oct-6 by IFNs and viruses in at least two different cell types, and involvement of Oct-6 in gene regulation after dsRNA treatment, suggest novel functions of Oct-6 in innate immune responses.
Storage stability of cod liver oil organogels formed with beeswax and carnauba wax (2014)

Abstract In this study, organogels of cod liver oil (CLO) with beeswax (BW) and carnauba wax (CW) were prepared, and compared with a commercial margarine (CM). Oil binding capacities (OBC) of BW organogels were over 99%, while CW had a maximum OBC value of 91.28%. Crystal formation time of BW was shorter. Although the highest solid fat content (SFC) was in the 10% CW containing sample (8.69%), it was 28.99% in the CM sample at 20 °C. The peak melting temperature of CM was 43.70 °C, and BW organogel at 3% addition had the closest values (45.42 °C). Firmness and stickiness values of the organogels were lower than that of CM sample. No significant change in the texture parameters during storage was detected, indicating good stability. There was no hurdle against oxidation by organogelation during storage. This study has shown that CLO organogels can be suitable spreadable products.
Oxidative Iodination of Deactivated Arenes in Concentrated Sulfuric Acid with I<sub>2</sub>/NaIO<sub>4</sub>and KI/NaIO<sub>4</sub>Iodinating Systems (2006)

Deactivated arenes were mono- or diiodinated with strong electrophilic I+ reagents, which were prepared from NaIO4 and either I2 or KI in concentrated H2SO4 (minimum 95% by weight). In general a small excess of the dark brown iodinating solution was used (1.1/1.5 equivalents, for nitrobenzene two equivalents was required). The iodinations were conducted at 25-30 °C with a reaction time of 1-2 hours using either a ‘direct’ or an ‘inverse’ method of aromatic iodination to give mono- or diiodinated pure products in 31-91% optimized yields.
<i>cis</i> and <i>trans</i> Configurations of the Peptide Bond in N-Monosubstituted Amides by Nuclear Magnetic Resonance (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTcis and trans Configurations of the Peptide Bond in N-Monosubstituted Amides by Nuclear Magnetic ResonanceLaurine A. LaPlanche and Max T. RogersCite this: J. Am. Chem. Soc. 1964, 86, 3, 337–341Publication Date (Print):February 1, 1964Publication History Published online1 May 2002Published inissue 1 February 1964https://pubs.acs.org/doi/10.1021/ja01057a007https://doi.org/10.1021/ja01057a007research-articleACS PublicationsRequest reuse permissionsArticle Views1620Altmetric-Citations295LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Discrete Mathematics Using Latin Squares (1998)

LATIN SQUARES. A Brief Introduction to Latin Squares. Mutually Orthogonal Latin Squares. GENERALIZATIONS. Orthogonal Hypercubes. Frequency Squares. RELATED MATHEMATICS. Principle of Inclusion--Exclusion. Groups and Latin Squares. Graphs and Latin Squares. APPLICATIONS. Affine and Projective Planes. Orthogonal Hypercubes and Affine Designs. Magic Squares. Room Squares. Statistics. Error--Correcting Codes. Cryptology. (t,m,s)--Nets. Miscellaneous Applications of Latin Squares. Appendices. Indexes.
Mutations ofCOL10A1 in Schmid metaphyseal chondrodysplasia (2005)

Schmid metaphyseal chondrodysplasia (SMCD) is a dominantly inherited cartilage disorder caused by mutations in the gene for the hypertrophic cartilage extracellular matrix structural protein, collagen X (COL10A1). Thirty heterozygous mutations have been described, about equally divided into two mutation types, missense mutations, and mutations that introduce premature termination signals. The COL10A1 mutations are clustered (33/36) in the 3' region of exon 3, which codes for the C-terminal NC1 trimerization domain. The effect of COL10A1 missense mutations have been examined by in vitro expression and assembly assays and cell transfection studies, which suggest that a common consequence is the disruption of collagen X trimerization and secretion, with consequent intracellular degradation. The effect of COL10A1 nonsense mutations in cartilage tissue has been examined in two patients, demonstrating that the mutant mRNA is completely removed by nonsense mediated mRNA decay. Thus for both classes of mutations, functional haploinsufficiency is the most probable cause of the clinical phenotype in SMCD.
TOPEX/Poseidon observations of mesoscale eddies over the Subtropical Countercurrent: Kinematic characteristics of an anticyclonic eddy and a cyclonic eddy (2004)

Relative dynamic heights and geostrophic fields were derived from TOPEX/Poseidon altimetry data and then used to track mesoscale eddies over the Subtropical Countercurrent (STCC). The radii, centers, vorticities, shearing deformation rates, stretching deformation rates, divergences, and center velocities of all identified eddies over the STCC were determined using a model that assumes constant velocity gradients. Most eddies are concentrated in a zonal band near 22°N, and there is an interannual variation in the number of eddies. A case study was made for a cyclonic eddy and an anticyclonic eddy, with time series of eddy kinematic parameters computed. Both eddies survive for ∼220 days and propagate westward along over 22°N–24°N to reach the Kuroshio Current east coast of Taiwan, where the eddies were dissipated and in turn affected the Kuroshio Current in many ways. Sea surface temperature data and drifter data confirm the existence of these two eddies. The radii of both eddies vary and their shapes are mostly elliptical during propagation. The anticyclonic eddy propagated almost westward with oscillating north‐south components, and the mean speed is 8.3 km/day. The cyclonic eddy moved southwestward before reaching 130°E and then moved northwestward, with a mean speed of 7.6 km/day. The propagations of these two eddies are basically consistent with the standard theory of eddy propagation but with larger speeds. The propagating direction could be altered while passing steep bottom topography or merging with the other eddies.
Multiple Glycosphingolipids Determine the Tissue Tropism of Parvovirus B19 (1995)

Infection with human parvovirus B19, the etiologic agent of fifth disease, is associated with numerous hematologic and nonhematologic complications. Recently, the receptor for parvovirus B19 was reported to be globoside (Gb4), a neutral glycosphingolipid (GSL) of red cell membranes. To ascertain if tissue Gb4 expression correlates with B19-associated disease, neutral GSLs from 16 human tissues were isolated and analyzed using high-performance thin-layer chromatography and immunostaining with anti-Gb4 monoclonal antibodies or B19 empty capsids. Gb4 was identified as a major neutral GSL in 11 tissues, especially in those of mesodermal origin. In addition to recognizing Gb4, B19 capsid bound to several tissue-specific GSLs, including two complex globo series GSLs (SSEA-3, SSEA-4) and paragloboside (neolactotetraglycosylceramide), as was demonstrated in red cell, granulocyte, kidney, liver, and bowel tissue. There was good correlation between tissue-neutral GSL expression, B19 capsid binding, and the tissue tropism observed clinically in B19 parvovirus-associated disease.
Chronic inflammation, the tumor microenvironment and carcinogenesis (2009)

Chronic inflammation often precedes or accompanies a substantial number of cancers. Indeed, anti-inflammatory therapies have shown efficacy in cancer prevention and treatment. The exact mechanisms that turn a wound healing process into a cancer precursor are topics of intense research. A pathogenic link has been identified between inflammatory mediators, inflammation related gene polymorphisms and carcinogenesis. Animal models of cancer have been instrumental in demonstrating the diversity of mechanisms through which every tumor compartment and tumor stage may be affected by the underlying inflammatory process. In this review, we focus on the interaction between chronic inflammation, tumor stem cells and the tumor microenvironment. We summarize the proposed mechanisms that lead to the recruitment of bone marrow derived cells and explore the genetic and epigenetic alterations that may occur in inflammation associated cancers.
Artificial Neuron (1959)

An electronic model is described for simulating many of the gross operational functions which are believed to hold for living nerve cells. Synaptic growth is not included. Despite difficulties in drawing very rigorous analogies between the biological cell and its model, a sufficient number of rough similarities exist to make systemic experimentation interesting. Several approaches are mentioned.
调整注册表，DIY Windows XP系统 (2005)

注册表，作为Windows操作系统的核心，很多功能人们都还没有合理利用起来。你想通过修改注册表来DIY操作系统吗？请看本文介绍的修改注册表改善Windows XP操作系统运行情况的技巧。
Clinical observation on the treatment of cervical headache with massage and traction (2007)

Objective:To explore the effect of massage and traction in treating cervical headache and analyze its mechanism.Methods:Fifty-six patients (22 male and 34 female with an average age of 46 years ranged from 19 to 65 years) with cervical headache were divided randomly into experimental group and control group.In experimental group,twenty-eight patients (12 male and 16 female with an average age of 44 years ranged from 19 to 60 years) were treated with massage and traction,and in control group,28 patients (10 male and 18 female with an average age of 48 years ranged from 22 to 65 years) were treated with single traction.The ache and tender degree,and therapeutic efficacy were observed.Mechanism of the two methods was analyzed.Results:All the index in the experimental group were better than those in the control group(P0.05).According to the standard of Clinical Principles of Treatment on Cervical Spondylopathy with Herbs and New Medicine, 22 cases were cured,3 cases improved dramatically,2 cases improved and 1 case ineffective in experimental group,the totally effective rate was 96.4%.13 cases cured,6 cases improved dramatically,3 cases improved and 6 cases ineffective in control group.The totally effective rate was 78.6%.There was a significant difference between the two groups(P0.05).Conclusion:Massage and traction in treating cervical headache provides a simple method with a high successful rate,satisfactory effect,scientific mechanism.This method can be easily popularized.
A Seed-specific Heat-shock Transcription Factor Involved in Developmental Regulation during Embryogenesis in Sunflower (2002)

We report the cloning and functional characterization of the first heat-shock transcription factor that is specifically expressed during embryogenesis in the absence of environmental stress. In sunflower embryos this factor, HaHSFA9, trans-activated promoters with poor consensus heat-shock cis-elements, including that of the seed-specific Hahsp17.6G1 gene. Mutations that improved the heat-shock cis-element consensus at the Hahsp17.7G4 promoter impaired transient activation by HaHSFA9 in sunflower embryos. The same mutations did not affect heat-shock-induced gene expression of this promoter in transgenic tobacco plants but reduced the developmental activation by endogenous heat-shock transcription factors (HSFs) in seeds. Sunflower, and perhaps other plants such as tobacco, differs from the vertebrate animal systems in having at least one specialized HSF with expression and (or) activation patterns strictly restricted to embryos. Our results strongly indicate that HaHSFA9 is a transcription factor critically involved in the developmental activation of Hahsp17.6G1 and in that of similar target genes as Hahsp17.7G4.
A Support Vector Regression Nonlinear Model for SiC MESFET (2007)

Support vector machine (SVM) regression approach is introduced in this paper for table-based nonlinear modeling of field effect transistors (FET). Support vector machine, which based on statistical learning theory and structural risk minimization (SRM) principle, is provided with good generalization ability. For the purpose of demonstration, a table-based SVM regression model is established using a set of training data and testing data produced by an available empirical nonlinear model of SiC MESFET. Experimental results are also given out to validate its good ability in predicting electrical performance.
A Contrastive Analysis of the Use of Verb "Keep": A corpus-based Study between CLEC and Brown (2010)

This is a corpus-based research focusing on the high-frequency verb ”keep” used by Chinese non-English majors and native speakers. The corpora involved in the paper are Brown which stands for native speakers, Students 3 and Students 4 in CLEC (Chinese Learner English Corpus) which stand for Chinese non-English majors. The paper tries to investigate the similarities and differences between them and put forward the possible reasons. At last, some suggestions of ELT (English Language Teaching) are given.
Chemical Fixation of Trace Elements in Coal Fly Ash (2007)

More than two-thirds of the coal combustion by-products (CCBs) produced in the United States are disposed of in dry landfills or in wet ash lagoons. Most of the older ash disposal sites are unlined and many are unmonitored. The US EPA is currently developing national standards for monitoring groundwater at coal combustion byproduct disposal facility (CCBDF) sites in the US. Development of effective techniques for in situ chemical fixation of trace elements in ash at closed CCBDFs would save the US electric utility industry billions of dollars in costs associated with excavation and lining of older disposal sites. Two treatment solutions were experimentally investigated as potential chemical fixation agents for trace elements present in fly ash collected at four different sites located in the Southeastern United States. Both treatment solutions contained the same concentration of ferrous sulfate, but calcium carbonate was added to the second solution to buffer the pH. The effectiveness of the treatment methods was evaluated through sequential batch leaching of treated ash samples using synthetic acid rain (SPLP). The best overall treatment method is FS at the 1:30 solid:liquid ratio. This treatment produces the lowest SPLP mobility for Mo and Sr (all ash samples), for B, Se and V (3 of the 4 ash samples) and for As (2 of the 4 ash samples). Overall reduction in trace element mobility after FS 1:30 treatment was As by 23-73%, B by 43-80%, Cr by 45-77%, Mo by 77-98%, Ni by 12-58%, Se by 49-92%, Sr by 29-58% and V by 41-53%. The chemical fixation treatment method developed is inexpensive, stable during prolonged leaching by acidic precipitation and easily implemented at closed CCBDF sites. In addition, the fixation technique may make possible increased utilization of CCB materials which have limited reuse potential due to their trace element contents.
Transorbital Penetrating Intracranial Injury Caused by Sheppard’s Hook (2010)

Intracranial injury resulting from transorbital penetrating objects is rare in a noncombat setting. As such there is a significant lack of data pertaining to the management of non-projectile traumatic brain injuries due to foreign bodies entering the brain. Intracranial complications can include intracerebral hematoma, cerebral contusion, intraventricular hemorrhage, pneumocephalus, brain stem injury, and carotid cavernous sinus fistula. This is the first report of a transorbital penetrating intracranial injury caused by a Sheppard's hook, which was managed utilizing a multi-disciplinary, non-operative approach.
Dual potential of microalgae as a sustainable biofuel feedstock and animal feed (2013)

The rise in global population has led to explorations of alternative sources of energy and food. Because corn and soybean are staple food crops for humans, their common use as the main source of dietary energy and protein for food-producing animals directly competes with their allocation for human consumption. Alternatively, de-fatted marine microalgal biomass generated from the potential biofuel production may be a viable replacement of corn and soybean meal due to their high levels of protein, relatively well-balanced amino acid profiles, and rich contents of minerals and vitamins, along with unique bioactive compounds. Although the full-fatted (intact) microalgae represent the main source of omega-3 (n-3) polyunsaturated fatty acids including docohexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the de-fatted microalgal biomass may still contain good amounts of these components for enriching DHA/EPA in eggs, meats, and milk. This review is written to highlight the necessity and potential of using the de-fatted microalgal biomass as a new generation of animal feed in helping address the global energy, food, and environmental issues. Nutritional feasibility and limitation of the biomass as the new feed ingredient for simple-stomached species are elaborated. Potential applications of the biomass for generating value-added animal products are also explored.
Compact Grating Structure for Application to Filters and Resonators in Monolithic Microwave Integrated Circuits (1987)

Possible high-Q circuits based on a new crosstie overlay slow-wave structure are proposed for monolithic microwave integrated circuits. Configurations and results of slow-wave factors are presented. This structure is used for construction of a frequency-selective reflector with a compact size. The effect of loss is considered.
Influence of age on metal metabolism and toxicity. (1978)

The metabolism and toxicity of lead, cadmium, mercury, and manganese in the postnatal period was studied in rats. Absorption, whole body retention, and organ distribution of 203Pb, 115mCd, 203Hg, and 54Mn were determined after oral and parenteral administration of these radioisotopes. The acute oral toxicity (LD50) was determined after a single application of metal chlorides. The results obtained in sucklings show a very high intestinal absorption of all metals which is partly attributed to milk diet; a higher whole body retention, higher blood levels and a much higher accumulation in the brain; and a higher oral toxicity. These results indicate age specific differences in the pharmacokinetics of metals in sucklings. It seems reasonable to consider the early neonatal age as a critical period for metal accumulation and therefore for metal toxicity. The results are interpreted on the basis of current concepts of developmental physiology and pharmacology and suggestions for future research trends are made.
A remote user interface framework for collaborative services using interconnected smart devices (2014)

This paper introduces a remote user interface framework which supports applications to share their view with remote smart devices. Besides that, a virtual IO function is provided to use mobile devices as remote controller. By thus, users can control home networked devices and applications by their smart devices with intuitive UI/UX. The proposed framework provides collaborative application model, APIs of sharing application view and virtual IO emulator.