gebhart/patrepeval huggingface dataset:
Nanostructures of tetranuclear copper(i) complexes with short Cu(i)⋯Cu(i) contacts: crystallization-induced emission enhancement (2011)

Tetranuclear copper(I) complexes containing N,N′-bis(5,7-dimethyl-1,8-naphthyridine-2-yl)amine and phosphine ligands with close intramolecular Cu(I)⋯Cu(I) contacts were found to precipitate as thermodynamically stable and crystalline quasi-2D sheet-like nanostructures. Kinetically stable, amorphous, spherical particles were also identified during the precipitation/crystallization processes of these copper(I) complexes in a dichloromethane/hexane mixture. The distinct phosphorescent properties of these two forms of nanostructures were studied and a crystallization-induced emission enhancement was observed during the morphological evolution from amorphous spherical particles to crystalline nanosheets. All of these photophysical properties were rationalized by density functional theory calculations.
Evaluation of the Safety, Immunogenicity, and Protective Efficacy of Whole Inactivated Simian Immunodeficiency Virus (SIV) Vaccines with Conformationally and Functionally Intact Envelope Glycoproteins (2004)

A novel, general approach to chemical inactivation of retroviruses was used to produce inactivated simian immunodeficiency virus (SIV) particles with functional envelope glycoproteins. Inactivated virions of three different virus isolates (SIVmne E11S, SIVmac239, and SIVmac239 g4,5), prepared by treatment with 2,2'-dithiodipyridine (aldrithol-2, AT-2), were not detectably infectious, in vitro or in vivo. Immunization of pigtailed macaques with inactivated SIVmne E11S particles, without adjuvant, induced both humoral and cellular immune responses. Four of six animals immunized with the inactivated particles did not show measurable SIV RNA in plasma (<100 copy Eq/ml) following intravenous challenge with pathogenic, homologous virus (SIVmne E11S), compared to peak values of > or =10(6) copy Eq/ml in challenged SIV-naive control animals (p = 0.0001). Despite the absence of measurable viral RNA in plasma in these animals, culturable virus and viral DNA were initially detectable in blood and lymph node specimens; in contrast to control animals, SIV DNA could no longer be detected in PBMC by 10 weeks postchallenge in five of six SIV-immunized animals (p = 0.0001). However, vaccines did not resist a sequential rechallenge with the heterologous pathogenic virus SIVsm E660. AT-2-inactivated virus with functional envelope glycoproteins is a novel class of vaccine immunogen and was noninfectious, under conditions of rigorous in vivo challenge, and induced both binding and neutralizing antibody responses, along with cellular immune responses. Results suggest that immunization facilitated effective containment of pathogenic homologous challenge virus. With further optimization, AT-2-inactivated viral particles may be a useful class of immunogen in the development of a vaccine to prevent AIDS.
Supercontinuum Generation with Output Power of 1.7 W Pumped by a Picosecond Laser Pulse (2010)

By using a photonic crystal fiber, a supercontinuum source with output power up to 1.7W, pumped by a passively mode-locked diode-pumped Nd:YVO4 picosecond laser is obtained. A spectral width of the supercontinuum is 1700 nm (500–2200 nm) with the 5 dB spectral width approximately 1000 nm (1200–2200 nm). This high power wide band supercontinuum source meets the demand of many applications such as optical coherence tomography, frequency metrology and wavelength-division-multiplexing systems. The evolution of the supercontinuum with the increasing pump power is presented and analyzed.
Task Partitioning with Replication upon Heterogeneous Multiprocessor Systems (2006)

The heterogeneous multiprocessor task partitioning with replication problem involves determining a mapping of recurring tasks upon a set consisting of different processing units in such a way that all tasks meet their timing constraints and no two replicas of the same task are assigned to the same processing unit. The replication requirement improves the resilience of the real-time system to a finite number of processor failures. This problem is NP-hard in the strong sense. We develop a Fully Polynomial-Time Approximation Scheme (FPTAS) for this problem.
RUBOXYL, A NEW NITROXYL DERIVATIVE OF DAUNORUBICIN - ACUTE TOXICITY AND ANTITUMOR EFFECT IN ANIMALS (1993)

Ruboxyl (RBX), a new nitroxyl derivative anthracycline, showed an interesting cytotoxic effect on in vitro established human cell lines and an antitumor activity in tumor-bearing animals. In this study, we further investigated the antitumor effect of this drug compared to Doxorubicin (DX) in four in vivo systems of experimental murine tumors. Our data demonstrate that RBX had little effect on the growth of primary tumor, and on the survival, in mice bearing Lewis lung carcinoma (3LL), while the drug showed a higher effect on the growth of B 16 melanoma. In both the experimental murine systems the activity of RBX was similar to that exerted by DX. As regards the leukemia models, RBX induced a significant increase on survival in mice bearing both L1210 or L5178Y leukemias. However, the effect on survival and the number of long-term survivors (LTS) were lower than that observed following DX treatment.
Pediatric Simulation in Canada - a Vision for the Future: a Report From the Canadian Pediatric Simulation Network (2010)

82%, 9/11). Finally, the top 3 barriers preventing Canadian simulation programs from moving forward over the next 5 years were identified as: lack of dedicated funding, lack of qualified instructors and associated training, and overall lack of support from hospital administration.conclusion: The results of this survey confirm the widespread use of simulation as an educational tool in most Canadian pediatric hospitals.Further growth of simulation in Canada will be dependent upon increased financial and administrative support at hospitals, as well as the development of a national instructor training course.
Effect of hypoxia on phosphatidylcholine biosynthesis in the isolated hamster heart (1990)

In hamster heart, the majority of the phosphatidylcholine is synthesized via the CDP-choline pathway, and the rate-limiting step of this pathway is catalysed by CTP:phosphocholine cytidylyltransferase (EC 2.7.7.15). We have shown previously [Choy (1982) J. Biol. Chem. 257, 10928-10933] that, in the myopathic heart, the level of cardiac CTP was diminished during the development of the disease. In order to maintain the level of CDP-choline, and consequently the rate of phosphatidylcholine biosynthesis, cardiac cytidylyltransferase activity was increased. However, it was not clear if the same compensatory mechanism would occur when the cardiac CTP level was decreased rapidly. In this study, hypoxia of the hamster heart was produced by perfusion with buffer saturated with 95% N2. The heart was pulse-labelled with radioactive choline and then chased with non-radioactive choline for various periods under hypoxic conditions. There was a severe decrease in ATP and CTP levels within 60 min of hypoxic perfusion, with a corresponding fall in the rate of phosphatidylcholine biosynthesis. Analysis of the choline-containing metabolites revealed that the lowered ATP level did not affect the phosphorylation of choline to phosphocholine, but the lower CTP level resulted in the decreased conversion of phosphocholine to CDP-choline. Determination of enzyme activities revealed that hypoxic treatment resulted in the enhanced translocation of cytidylyltransferase from the cytosolic to the microsomal form. This enhanced translocation was probably caused by the accumulation of fatty acids in the heart during hypoxia. We postulate that the enhancement of translocation of the cytidylyltransferase to the microsomal form (a more active form) is a mechanism by which the heart can compensate for the decrease in CTP level during hypoxia in order to maintain phosphatidylcholine biosynthesis.
Enantiomeric Recognition of Organic Ammonium Salts by Chiral Pyridino-18-Crown-6 Ligands: A Short Review (1992)

Abstract A short review of enantiomeric recognition of chiral organic ammonium salts by chiral pyridino-18-crown-6 ligands is presented. Topics include preparation of chiral macrocycles and details of enantiomeric recognition as determined by 1H NMR and calorimetry techniques. The chiral pyridino-18-crown-6 ligands containing two tert-butyl or two phenyl substituents on chiral macroring carbon atoms exhibited the highest recognition for the enantiomers of [α-(1-naphthyl)ethyl]ammonium perchlorate of any chiral pyridino-18-crown-6 ligands studied. Key Words: Chiral pyridino-18-crown-6 ligandschiral organic ammonium ionsenantiomeric recognition
Heterogeneity in Responses to Cancer. Part II: Sexual Responses (1991)

Heterogeneity in psychosexual responses to disease-specific diagnosis is demonstrated for two groups of cancer patients with testis cancer and Hodgkin's disease who are comparable in prognosis and treatment intensity. The two groups of patients and their partners are shown to differ in their ability to recover from psychiatric problems associated with the diagnosis and/or treatment of cancer.
Multi-Pitch Estimation Using Harmonic Music (2006)

In this paper, we present a method for estimation of the fundamental frequencies, or pitches, of several periodic sources. This difficult estimation problem occurs, for example, in speech and audio processing whenever multiple speakers or tones are present. The presented method is an extension of a recently proposed method for estimation of the fundamental frequency of a set of harmonically related sinusoids based on the MUSIC criterion. The estimator takes into account that the number of harmonics and sources may vary. The performance of the proposed method is evaluated in Monte Carlo simulations using synthetic signals under various conditions.
About the significance of peroxide decomposition products in XLPE cable insulations (1976)

The investigations are concerning with voltage stabilizing effects of peroxide decomposition products, measured by treeing resistance.
ChemInform Abstract: Total Synthesis of Fostriecin (CI‐920) via a Convergent Route. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Robust Design of Flexure Based Nano Precision Compliant Mechanisms With Application to Nano Imprint Lithography (2008)

Flexure-based compliant mechanisms are the preferred motion guiding systems for small range, nano-precision positioning applications because of excellent characteristics like friction-free continuous motion. These mechanisms are commonly used in nano fabrication equipment and ultra precision instruments. However, machining imperfections induced geometric errors in the mechanisms are known to cause undesirable parasitic motion and significant loss of precision. A systematic design approach to minimize the sensitivity of the flexure mechanisms to geometric errors induced by machining tolerances is presented here. Central to the design approach is the screw systems based analytical model to study the spatial motion characteristics of flexure mechanisms. Using this model, the parasitic motion is classified into those errors which can be corrected by calibration (extrinsic) and those which are coupled with the mechanism motion and cannot be corrected by apriori calibration (intrinsic). Metric to quantify the intrinsic parasitic motion results naturally from the screw systems analysis, and is used to represent the precision capability of the flexure mechanism. The analytical model enables the selection of geometric parameters of flexure joints of the mechanism via an optimization scheme with the aim of minimizing the parasitic motion metric. The statistical nature of the machining tolerances is accounted for by sampling the random variables at every iteration step of the optimization, leading to a stochastic formulation. The robust design approach is illustrated using a one DOF rotational flexure mechanism that is used in nano-imprint lithography equipment. Numerical results of the optimization indicate up to 40% improvement in the precision capability of the mechanism without any change in the manufacturing tolerance limits. Further, it is shown via eigenscrew analysis of mechanism compliance that the robustness resulting from the optimal flexure joint design can be attributed to the improved compliance distribution.
Faculty Opinions recommendation of Revisiting the Koebner phenomenon: role of NGF and its receptor system in the pathogenesis of psoriasis. (2008)

Nerve growth factor (NGF) influences the key pathological events of psoriasis: keratinocyte proliferation, angiogenesis, and T-cell activation. We have systematically examined the kinetics of NGF expression, keratinocyte proliferation, and migration of T lymphocytes in the epidermis in Koebner-induced developing psoriatic plaques. In skin traumatized by the tape-stripping method (n = 12), a marked up-regulation of NGF in Koebner-positive lesions (n = 7) was observed 24 hours after trauma. Synthesis of NGF reached its maximum level in the 2nd week. Furthermore, cultured keratinocytes from nonlesional skin of psoriasis patients produced 10 times higher levels of NGF compared with keratinocytes from healthy individuals. To substantiate the in vivo effect of NGF secreted by keratinocytes in psoriatic plaques, we studied psoriatic plaques and normal human skin in a SCID-human skin xenograft model. The transplanted psoriatic plaques demonstrated marked proliferation of NGF-R (p75)-positive nerve fibers compared with only a few nerves in the transplanted normal human skin. Our results demonstrate that 1) in a developing psoriatic lesion, up-regulation of NGF together with keratinocyte proliferation are early events and precede epidermotropism of T lymphocytes; 2) keratinocytes in patients with psoriasis are primed to produce elevated levels of NGF; and 3) NGF synthesized by these keratinocytes is functionally active. PMID: 18349121
Pointing and tracking servo for the Haystack auxiliary antenna (HAX) (2003)

An overview of the servo design for a 40-ft-diameter radar dish two-axis mount is presented. Several fundamental upgrades were implemented, including a four-quadrant six-pulse phase control rectifier power amplifier system, a microcontroller-based maintenance chassis, a high-resolution encoding system, and digital servo compensation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Multifocal ERG in Diabetic Patients without Retinopathy during Euglycemic Clamping (2005)

During acute normoglycemia, patients with type 1 diabetes without retinopathy demonstrated a delayed mfERG response compared with the healthy subjects. The delay was more pronounced during euglycemia than during hyperglycemia, and at both levels of glycemia, the delay was proportional to the patients' habitual hyperglycemia. The results show that chronic hyperglycemia induces an adaptational response that tends to normalize retinal implicit times at a higher level of habitual glycemia.
Stonecutters Bridge, Hong Kong: the reference scheme (2012)

This paper describes the concept design for Stonecutters Bridge, Hong Kong – the winning scheme in the international design competition held by the Highways Department of the Hong Kong Special Administrative Region. The design was prepared by the competition winners, a team from Halcrow Group Ltd., Flint & Neill Partnership, the Shanghai Municipal Engineering Design Institute and Danish architects Dissing+Weitling. The concept design became the reference scheme for the development of the project.
Polyalkylene Disulfides (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolyalkylene DisulfidesC. S. Marvel and L. Elmer OlsonCite this: J. Am. Chem. Soc. 1957, 79, 12, 3089–3091Publication Date (Print):June 1, 1957Publication History Published online1 May 2002Published inissue 1 June 1957https://pubs.acs.org/doi/10.1021/ja01569a027https://doi.org/10.1021/ja01569a027research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FHIT mutations in human primary gastric cancer. (1997)

Allelic deletion of multiple regions on the short arm of chromosome 3 (3p) implies the presence of multiple important tumor suppressor genes in human carcinogenesis. The FHIT gene, identified recently in chromosome 3p14.2, shows frequent allelic deletion and aberrant transcripts in gastrointestinal tumors. After determining the intron sequences flanking each of the coding exons of the FHIT gene and designing intron primers to facilitate mutation analysis of genomic DNA samples, we analyzed the complete coding sequences in matched cancer and normal tissues from 40 cases with primary gastric cancer using intron primers, PCR-single-strand conformation polymorphism analysis, and direct sequencing. A somatic missense mutation in exon 6, codon 61, ACG (threonine) --> ATG (methionine) was found in a signet ring cell adenocarcinoma. We also evaluated allelic deletion in these tumors by PCR-based microsatellite analysis; allelic deletion occurred in 42.1% (16 of 38) of evaluable cases. This is the first report of a somatic missense mutation of the FHIT gene in a primary tumor. Presence of a point mutation and frequent allelic deletions are consistent with the hypothesis that FHIT gene alterations are involved in the development of primary gastric cancers.
On the Question of Content and Distribution of Amines in the Rat Testis during Development<sup>1</sup> (1974)

Attempts were made to confirm the studies by Zieher et al. (3) on the cellular stores of certain biogenic amines in the developing rat testis. A combination of fluorometric determinations, fluorescence histochemistry and cytospectrofluorometry was used. The results obtained disagreed with those reported by Zieher et al. (3): only small amounts of 5-HT and histamine were present at birth, and little or no dopamine was found. The values for 5-HT and histamine may well correspond to the number of histochemically visible mast cells containing these two amines. There was no evidence that the testicular tubules and endocrine interstitial cells contained any significant amounts of dopamine or 5-HT. (Endocrinology95: 1746, 1974)
RNA knockdown by synthetic peptidyl-oligonucleotide ribonucleases: behavior of recognition and cleavage elements under physiological conditions (2020)

Sequence-specific <i>protein-based</i> ribonucleases are not found in nature. Absolute sequence selectivity in RNA cleavage <i>in vivo</i> normally requires multi-component complexes that recruit a guide RNA or DNA for target recognition and a protein-RNA assembly for catalytic functioning (e.g. RNAi molecular machinery, RNase H). Recently discovered peptidyl-oligonucleotide synthetic ribonucleases selectively knock down pathogenic RNAs by irreversible cleavage to offer unprecedented opportunities for control of disease-relevant RNA. Understanding how to increase their potency, selectivity and catalytic turnover will open the translational pathway to successful therapeutics. Yet, very little is known about how these chemical ribonucleases bind, cleave and leave their target. Rational design awaits this understanding in order to control therapy, particularly how to overcome the trade-off between sequence specificity and potency through catalytic turnover. We illuminate this here by characterizing the interactions of these chemical RNases with both complementary and non-complementary RNAs using T<sub>m</sub> profiles, fluorescence, UV-visible and NMR spectroscopies. Crucially, the level of counter cations, which are tightly-controlled within cellular compartments, also controlled these interactions. The oligonucleotide component dominated interaction between conjugates and <i>complementary</i> targets in the presence of physiological levels of counter cations (K<sup>+</sup>), sufficient to prevent repulsion between the complementary nucleic acid strands to allow Watson-Crick hydrogen bonding. In contrast, the positively-charged catalytic peptide interacted poorly with target RNA, when counter cations similarly screened the negatively-charged sugar-phosphate RNA backbones. The peptide only became the key player, when counter cations were insufficient for charge screening; moreover, only under such non-physiological conditions did conjugates form strong complexes with <i>non-complementary</i> RNAs.Communicated by Ramaswamy H. Sarma.
Carborane‐Substituted Bis(phosphino)hydrazines: Selective Formation of Six‐ and Twelve‐Membered P,N Heterocycles (2018)

Six‐ and twelve‐membered heterocyclic carborane‐substituted bis(phosphino)hydrazines 1 and 2 were obtained selectively. Compound 1 was obtained as the major product in a 1:1 reaction, when the dilithiated o ‐carborane was added to 1,2‐bis(dichlorophosphino)‐1,2‐diethylhydrazine, whereas the reverse addition led to 2 as the main product (2:2 reaction). Compound 1 was obtained only as the rac isomer, 2 as the R P , S P , S P , R P isomer. The rhodium(I) complex of 1 , rac ‐[{RhCl(η 4 ‐C 8 H 12 )} 2 { cyclo ‐1,2‐(NEt) 2 ‐3,6‐(PCl) 2 ‐4,5‐( ortho ‐C 2 B 10 H 10 )‐κ P ,κ P′ }] ( 3 ), shows dynamic behavior due to a temperature‐dependent equilibrium. Preliminary studies showed the rhodium(I) complex generated in situ from 1 and [Rh(cod) 2 ]BF 4 (cod = 1,5‐cyclooctadiene) to be an active catalyst in the hydrogenation of dimethyl itaconate.
Reaction of Amide Homologs. IX. Catalytic Hydrogenation of Azomethines in the Presence of Amide and its Mechanism. (1963)

Catalytic hydrogenation of some azomethines, such as N-benzylideneaniline, N-benzylidenebenzylamine, and N- (4-methoxybenzylidene) phenethylamine in the presence of amide was examined under high pressure of hydrogen. The reaction resulted in conversion, ArCH=NR+2R'CONH2+H2→ArCHNHCOR'+RNHCOR'+NH3, particularly in excellent yields with formamide. With regard to this reaction path, it was recognized that the initiating essential reaction between azomethine and formamide would be the reaction, ArCH=NR+HCONH2→ArCH=NH+RNHCHO (NH3 acts as a catalyst), which was demonstrated by using N-benzylidene-4-sulfonamidobenzylamine as azomethine. Based on this reaction, the whole pathway for the above hydrogenation reaction was proposed. Mechanism for hydrogenation reaction of nitriles, oximes, and ammoniaaldehyde mixtures in the presence of formamide was also suggested.
Towards an IEEE 802.15.4 SDR transceiver (2010)

One of the goals of a software defined radio system is to be adaptable to send and receive data according to several specifications. That can be achieved if that system implements most of the communication operations, including physical layer tasks, in reconfigurable platforms. This paper introduces an all-digital transceiver based on the 868 MHz band of the IEEE 802.15.4 standard. The design consist of a transmitter with a bandpass delta-sigma modulator and an undersampling receiver. A Xilinx Virtex-5 FPGA is used to implement the proposed model.