gebhart/patrepeval huggingface dataset:
Rho-Effektor-Interaktion: Struktur-Funktionsbeziehungen (2004)

Ein entscheidender Schritt bei der Signaltransduktion der RhoGTPasen ist die Bindung und Aktivierung von\nEffektorproteinen. Die Fähigkeit der Rho-Proteine mit verschiedenen Effektoren zu interagieren, ist die Grundlage ihres\nfunktionellen Spektrums und der Divergenz Rho-vermittelter Signalwege. Da die molekularen Mechanismen der Rho-Effektor-\nInteraktion noch weitesgehend unverstanden sind, stand eine detaillierte Untersuchung der Struktur-Funktionsbeziehung\nverschiedener Effektorproteine im Zentrum dieser Arbeit.\nDurch die Strukturaufklärung von ROCK-RBD im Komplex mit aktivem RhoA, sowie der biochemischen Charakterisierung\nverschiedener Effektor-RBDs unter Verwendung eines fluoreszenzspektroskopischen Assays wurden neue Erkenntnisse über\ndie RhoA-Effektor-Interaktion gewonnen. Zusammen mit der Entdeckung zweier neuer Rho-bindender Domänen in ROCK und den\nErgebnissen aus Mutationsstudien wird zum ersten Mal ein Modell für die Rho-vermittelte Effektor-Interaktion\nvorgeschlagen.
Integration of GaN Crystals on Micropatterned Si(0 0 1) Substrates by Plasma-Assisted Molecular Beam Epitaxy (2015)

We present an innovative approach to integrate arrays of isolated, strain-free GaN crystals on patterned Si substrates. First, micrometer-sized pillars are patterned onto Si(0 0 1) substrates. Subsequently, 2.5 μm Si substrates are deposited by low-energy plasma-enhanced chemical vapor deposition, forming crystals mostly bounded by {1 1 1}, {1 1 3}, and {15 3 23} facets. Plasma-assisted molecular beam epitaxy is then used for GaN deposition. GaN crystals with slanted {0 0 0 1} facets having a root-mean-square surface roughness of 0.7 nm are obtained for a deposited material thickness of >3 μm. Microphotoluminescence measurements performed at room and cryogenic temperature show no yellow luminescence and a neutral donor-bound A exciton transition at 3.471 eV (10 K) with a full width at half-maximum of 10 meV. Microphotoluminescence and micro-Raman spectra reveal that GaN grown on Si pillars is strain-free. Our results indicate that the shape of GaN crystals can be tuned by the pattern periodicity and that a reduction of threading dislocations is achieved in their top part.
Supporting Procedural Constructs in SQL Compilers (1996)

will describe an integrated approach that extends existing query compilers to support SQL/PSM-like procedural extensions. This work was a joint devel-opment at the IBM Santa Teresa Lab. with Gene
Evidence for space charge in atomic layer epitaxy ZnS:Mn alternating-current thin-film electroluminescent devices (1993)

Electrical and optical measurements of ZnS:Mn alternating-current thin-film electroluminescent (ACTFEL) devices grown by atomic layer epitaxy provide evidence for the existence of space charge within the bulk ZnS layer. Blue luminescence is observed during the falling edge of an applied voltage pulse when the ACTFEL device is operated at low temperature. This blue luminescence is attributed to donor-acceptor pair radiative recombination in which chlorine is identified as the donor and a zinc vacancy as the acceptor. This luminescence identification leads to determination of the origin of space charge as arising from impact ionization of the zinc vacancy.
Ti-Zr-V thin films as non-evaporable getters (NEG) to produce extreme high vacuum (2008)

Non-evaporable getter (NEG) materials have become an integral part of many ultrahigh vacuum environments mainly due to their unique surface properties which are conducive to achieving extreme-high vacuum conditions of the order of 10−12 mbar and lower. These unique surface properties that lead to the gettering process can be found in pure metals as well as binary, ternary and multicomponent alloys from IV and V group elements of the periodic table. In this paper, we are describe target preparation in alloy forms using pure titanium, zirconium and vanadium metals and preparation of Ti-Zr-V NEG thin films by a vacuum arc evaporation technique. The getter activation mechanism was investigated extensively by heat-treating the films under UHV conditions and characterizing using an in-situ XPS technique. The measurements of the activated getter films show the disappearance of the superficial oxide layer through the variation in the oxygen stoichiometry during thermal activation. The lowest activation temperature of about 160°C for a 2h heat-treatment was achieved with these films. Results of these studies show that the deposited films of Ti-Zr-V could be used as NEG to produce extreme high vacuum.
ChemInform Abstract: SYNTHESES OF HETEROCYCLIC COMPOUNDS. DCXXVII. FORMATION OF 2,3,9,10‐TETRAMETHOXYBENZ(C)ACRIDINE BY TREATMENT OF 6,7‐DIMETHOXY‐1‐(4,5‐DIMETHOXY‐2‐NITROPHENETHYL)‐2‐METHYLISOQUINOLINE WITH TRIETHYL PHOSPHITE (1976)

Abstract Das aus dem Amid (I) durch eine Bischler‐Napieralski‐Cyclisierung hergestellte Dihydroisochinolin (II) wird in das N‐Methylderivat (III) übergeführt.
Retrospective Analysis of Carboplatin and Paclitaxel as Initial Second-Line Therapy for Recurrent Epithelial Ovarian Carcinoma: Application Toward a Dynamic Disease State Model of Ovarian Cancer (2002)

PURPOSE: The majority of patients with epithelial ovarian cancer (EOC) who achieve a complete remission with front-line chemotherapy develop recurrent disease. Carboplatin and paclitaxel are used for patients with platinum-sensitive recurrent disease, although there is little information regarding the response and survival in unselected patients treated with this strategy. We sought to determine the outcomes for patients with EOC treated with carboplatin and paclitaxel at the time of first recurrence. In addition, we sought to define a new paradigm for disease transition in patients with EOC. PATIENTS AND METHODS: Eighty-nine patients were identified who had a complete response to front-line platinum-based chemotherapy for EOC, relapsed 6 months after completion of front-line chemotherapy, and were treated with carboplatin and paclitaxel as second-line therapy. RESULTS: Eighty-four cases were available for analysis of survival end points, and 66 were assessable for response. The median follow-up was 27 months. The overall response rate was 70%. The median progression-free interval for the cohort was 13 months (95% confidence interval [CI], 10.7 to 13.8 months). The 3-year survival rate was 72% (95% CI, 59.4 to 86.1%). Toxicity was limited, and no deaths from treatment were observed. Using this data, it is possible to construct a disease states model of EOC, which provides risk estimates for transitions between clinically distinct categories. CONCLUSION: Re-treatment with carboplatin and paclitaxel is effective as initial therapy in recurrent EOC. This should form the basis of a randomized trial to determine the best agents for initial treatment of relapse from EOC in potentially platinum-sensitive patients.
Minimum Miscibility Pressure Investigations for a Gas Injection EOR Project in Al Shaheen Field, Offshore Qatar (2009)

Abstract Gas injection as an EOR method is being considered for the giant Al Shaheen field, located offshore Qatar. The field is characterized by large lateral variations in fluid properties; the oil gravity ranges from 16 to 38 °API and significant variations in initial GOR and saturation pressure are observed. An extensive experimental program aimed at establishing the miscibility behaviour for this complex fluid system has been performed. Experiments included a range of gas injection tests such as swelling and multi-contact miscibility tests, enrichment studies and slimtube measurements. The miscibility behaviour across the range of oil gravities has been very well captured with a single equation of state (EOS) model, as described by Lindeloff et al. (2008). Slimtube measurements are the preferred method for establishing minimum miscibility pressures experimentally as condensing/vaporizing effects can be captured in this setup. The physical dispersion of the slimtube was characterized by a specially designed experiment using first-contact miscible (FCM) fluids. The results of the FCM experiments were used to determine the degree of numerical dispersion required in a 1D slimtube simulation model to match the measured data. An extrapolation towards an infinite number of cells was then performed to estimate the dispersion-free minimum miscibility pressure (MMP) from the slimtube experiments conducted on live reservoir oil using carbon dioxide as injection gas. In addition to the slimtube simulations, several algorithms for estimating the minimum miscibility pressure have been compared; some are empirical correlations, others are based on analytical gas injection theory using the method of characteristics (MOC) limiting tie-line method and the last one relies on a mixing-cell approach. The advantages and drawbacks of each approach are discussed, and the results are compared to laboratory data. In general, there is a very large spread in predicted MMP using carbon dioxide as injection gas. Empirical correlations generally overpredict the MMP for light oils and underestimate the MMP for heavy oils. Various key tie-line methods using the same tuned EOS model provide very different estimates of the MMP and some of them exhibit convergence problems. The results of the present work suggest that the mixing-cell model provides the most robust estimate of MMP over a large range of oil compositions, subject to EOS description. In essence, there is currently no prediction method that can replace the slimtube experiments.
A New Multiprogrammable Isotopic Powered Cardiac Pacemaker (1982)

A new multiprogrammable, isotopic-powered cardiac pacemaker was implanted in six patients as a custom device. Five were initial implants and one was a replacement. The patients were studied for up to two years. In five of the six cases it was found advantageous to change one of the programmable parameters. Multiprogrammability is obviously as important in an isotopic pulse generator as in a lithium unit, if not more so, because of the unit's greater longevity. Further studies are continuing in an FDA approved clinical trial.
Closed-Loop Positioning of Hemiplegic Patient's Joint by Means of Functional Electrical Stimulation (1974)

We report about the results on positioning of the ankle joint of a hemiplegic patient and of normal experimental subjects, using functional electrical stimulation (FES) of antagonistic muscle groups and position feedback. Such a controller is intended to be used as the execution level of a multilevel orthotic system. The synthesis of the controller has been made with the aid of the components of an analog hybrid computer. Experimental results show that the static and dynamic properties of regulated movements are not essentially inferior to the properties of voluntary movements. There are stated technological problems that will have to be solved before the controller can be clinically applied for rehabilitation purposes. At the present state of the art, the poor technology of FES, the unsolved problem of fatigue with FES muscles, size, price, and bad cosmetic effect prevent the position controller from being clinically applicable.
Isolation, characterization, and distribution of a novel neuropeptide, <i>Rana</i> RFamide (R‐RFa), in the brain of the European green frog <i>Rana esculenta</i> (2002)

A novel neuropeptide of the RFamide peptide family was isolated in pure form from a frog (Rana esculenta) brain extract by using reversed-phase high performance liquid chromatography in combination with a radioimmunoassay for mammalian neuropeptide FF (NPFF). The primary structure of the peptide was established as Ser-Leu-Lys- Pro-Ala-Ala-Asn-Leu-Pro-Leu- Arg-Phe-NH(2). The sequence of this neuropeptide, designated Rana RFamide (R-RFa), exhibits substantial similarities with those of avian LPLRFamide, gonadotropin-inhibitory hormone, and human RFRP-1. The distribution of R-RFa was investigated in the frog central nervous system by using an antiserum directed against bovine NPFF. In the brain, immunoreactive cell bodies were primarily located in the hypothalamus, i.e., the anterior preoptic area, the suprachiasmatic nucleus, and the dorsal and ventral hypothalamic nuclei. The most abundant population of R-RFa-containing neurons was found in the periependymal region of the suprachiasmatic nucleus. R-RFa- containing fibers were widely distributed throughout the brain from the olfactory bulb to the brainstem, and were particularly abundant in the external layer of the median eminence. In the spinal cord, scattered immunoreactive neurons were found in the gray matter. R-RFa-positive processes were found in all regions of the spinal cord, but they were more abundant in the dorsal horn. This study provides the first characterization of a member of the RFamide peptide family in amphibians. The occurrence of this novel neuropeptide in the hypothalamus and median eminence and in the dorsal region of the spinal cord suggests that, in frog, R-RFa may exert neuroendocrine activities and/or may be involved in the transmission of nociceptive stimuli.
Effectiveness of catheter ablation of atrial fibrillation according to heart failure etiology (2020)

Catheter ablation in patients with AF and concomitant heart failure leads to significant improvements in functional and symptom status without significant differences between patients with ischemic vs nonischemic HF etiology.
Sequence arrangement of the rRNA genes of the dipteran Sarcophaga bullata (1981)

Velocity sedimentation studies of RNA of Sarcophaga bullata show that the major rRNA species have sedimentation values of 26S and 18S. Analysis of the rRNA under denaturing conditions indicates that there is a hidden break centrally located in the 26S rRNA species. Saturation hybridization studies using total genomic DNA and rRNA show that 0.08% of the nuclear DNA is occupied by rRNA coding sequences and that the average repetition frequency of these coding sequences is approximately 144. The arrangement of the rRNA genes and their spacer sequences on long strands of purified rDNA was determined by the examination of the structure of rRNa:DNA hybrids in the electron microscope. Long DNA strands contain several gene sets (18S + 26S) with one repeat unit containing the following sequences in order given: (a) An 18S gene of length 2.12 kb, (b) an internal transcribed spacer of length 2.01 kb, which contains a short sequence that may code for a 5.8S rRNA, (c) A 26S gene of length 4.06 kb which, in 20% of the cases, contains an intron with an average length of 5.62 kb, and (d) an external spacer of average length of 9.23 kb.
Design and control strategy of humanoid lower limb exoskeleton driven by pneumatic artificial muscles (2016)

This paper firstly introduces a humanoid lower limb exoskeleton (HLLE) actuated by pneumatic artificial muscles. It is almost anthropomorphic and retains six degrees of freedom (DOFs) for each lower limb. Pneumatic artificial muscle (PAM) is designed and manufactured according to McKibben principle which has already been examined to acquire the basic static performance. Then, the fuzzy self-tuning PID (FSPID) control based on pulse-width modulation (PWM) is purposed to control the motion of HLLE and it is an effective strategy which does not rely on the kinetic model of the lower limb. Besides, inertial measurement units (IMUs) are installed on certain components to receive precise motion parameters timely, which aim to be able to get helpful feedback results. As the control center of the system, microcontroller unit (MCU) is mainly responsible for communicating with sensors and PC, generating PWM signals to regulate valves and dealing with data. In the application of the HLLE, an effective intelligent control strategy for lower limbs with PAMs is expected to acquire; and the research result is to be applied to the human body which is wearing HLLE in the future. As a consequence, what we have researched contributes much to the application of pneumatic artificial muscles in several fields, such as intelligent prosthesis device, medical rehabilitation exoskeleton and power-assisted exoskeleton. In the end, this paper gives an outline of the prospected work for later experimental research.
DIFFUSION IN MULTICOMPONENT METALLIC SYSTEMS: V. INTERSTITIAL DIFFUSION IN DILUTE TERNARY AUSTENITES (1962)

A statistical calculation of the interstitial diffusion flux in a face-centered cubic lattice containing one dilute interstitial component and one substitutional component leads to a relation between the on-diagonal and off-diagonal diffusion coefficients,[Formula: see text]where the [Formula: see text]'s are pair interaction energies and N is the mole fraction. Alternatively, we may combine the thermodynamic relation obtained by neglecting thermodynamic forces due to off-diagonal chemical potential gradients,[Formula: see text]with a nearest-neighbor, regular solution calculation of the thermodynamic activities to obtain the same result.The latter thermodynamic relation is put to the experimental test for the ternary systems Fe–C–Si and Fe–C–Mn by substituting empirical thermodynamic data and comparing with values of D 12 /D 11 obtained by means of a "transient equilibrium" diffusion experiment. In both systems the deviations lie within the experimental and analytical errors.
Mouse interferon gamma pretreated hepatocytes conditioned media suppress cytochrome P-450 induction by TCDD in mouse hepatoma cells. (1993)

Mouse interferon gamma (IFN-G) markedly suppressed 7-ethoxyresorufin o-deethylase (EROD) activity when added at the same time as TCDD in mouse primary hepatocyte cultures. IFN-G, however, had no effect on EROD induction by TCDD in Hepa-1 cells, a mouse hepatoma cell line, or Hepa-1 cells cocultured with Kupffer cells when added directly to the culture. EROD induction by TCDD in Hepa-1 cells was suppressed when cells were cultured with IFN-G pretreated mouse hepatocytes conditioned media. The magnitude of suppression was related to the dose of IFN-G and the density of hepatocytes used for the preparation of the conditioned media. Treatment of the monoclonal antibody against IFN-G to the conditioned media did not block the suppression of EROD induction. The suppressive effect of IFN-G pretreated hepatocytes conditioned media on EROD induction, however, was blocked when the conditioned media was heated or treated with trypsin. These results suggested that IFN-G pretreated mouse hepatocytes may release a soluble protein factor(s) which suppressed the EROD induction by TCDD in Hepa-1 cells.
Colloidally Stable Germanium Nanocrystals for Photonic Applications (2010)

We report the development of a straightforward synthesis for colloidally stable germanium nanocrystals for use as a solution-processable precursor for the bottom-up fabrication of functional thin films. SiO(2)-embedded germanium nanocrystals are produced by the reductive thermal processing of sol-gel glasses derived from mixtures of tetraethoxyorthogermanate (TEOG) and tetraethoxyorthosilicate (TEOS), and free-standing germanium nanocrystals are liberated from the encapsulating silicon dioxide through sequential chemical etching. The applicability of these germanium nanocrystals as a solution-processable thin film precursor is demonstrated by the fabrication of high refractive index thin films.
Low bitrate informed source separation of realistic mixtures (2013)

Demixing consists in recovering the sounds that compose a multichannel mix. Important applications include karaoke or respatialization. Several approaches to this problem have been proposed in a coding/decoding framework, which are denoted either as spatial audio object coding or informed source separation. They assume that the constituent sounds are available at an encoding stage and used to compute a side-information transmitted to the end-user. At a decoding stage, only the mixtures and the side information are used to recover the sources. Here, we propose an advanced model, which encompasses many practical scenarios and permits to reach bitrates as low as 0:5kbps/source. First, the sources may be mono or multichannel. Second, the mixing process is assumed to be diffuse, generalizing the usual linear-instantaneous or convolutive cases and permitting professional mixes to be processed. Third, the signals to be recovered may either be the original sources or their spatial images.
Rocket motor casing Patent (1966)

Regeneratively cooled rocket motor casing with tapered channels to insure minimum thicknesses at each channel cross section for necessary strength requirements
<i>TOP2A</i> aberrations as predictive and prognostic marker in high-risk breast cancer patients. A randomized DBCG Trial (DBCG89D) (2006)

532 Background: The primary objective of the study was to evaluate TOP2A as predictive marker for adjuvant treatment with epirubicin in high-risk breast cancer patients. As a secondary objective the prognostic characteristics of TOP2A gene aberrations was investigated. The data presented on the predictive properties is a follow-up to the data previously published (Knoop et al, J Clin Oncol 2005; 23: 7483–90). Methods: 962 pre- and postmenopausal high-risk Danish patients were enrolled in the DBCG89D protocol. The patients were randomly allocated to either 9 × CMF (cyclophosphamide, methotrexate, 5-flurouracil) (n=495) or 9 × CEF (cyclophosphamide, epirubicin, 5-flurouracil) (n=467) every 3 weeks. Tumor-tissue was available from 806 patients (84%). The tumors were analyzed for TOP2A copy number changes with the TOP2A FISH pharmDx Kit (Dako, Glostrup). Recurrence-free survival (RFS) was used as primary end-point. Univariate and multivariate statistics were used to assess the predictive and prognostic properties of the TOP2A gene aberrations. Results: The TOP2A test was successful in 96% of the patients. Ninety-two (12.0%) patients were found to have TOP2A amplified tumors, and 86 (11.1%) to have TOP2A deleted tumors. For the primary study endpoint (RFS) a significant predictive value of TOP2A gene amplifications was found (HR=0.39; CI: 0.22–0.70; p=0.0017). A similar trend was seen with respect to TOP2A deletions (HR=0.61; CI: 0.35–1.07; p=0.082). TOP2A gene aberrations were significantly associated with several established prognostic factors and had independent prognostic value, associated with a significant worse prognosis both for RFS (p=0.036) and overall survival (p=0.012). Conclusions: The DBCG89D study has shown that TOP2A amplifications are associated with a favorable outcome of adjuvant treatment with epirubicin in primary breast cancer. Further, TOP2A aberrations demonstrated an independent prognostic value. [Table: see text]