gebhart/patrepeval huggingface dataset:
Thymus‐dependent modulation of Ly49 inhibitory receptor expression on NK1.1<sup>+</sup>γ/δ T cells (2001)

Major histocompatibility complex (MHC) class I-specific inhibitory receptors are expressed not only on natural killer (NK) cells but also on some subsets of T cells. We here show Ly49 expression on gamma/delta T cells in the thymus and liver of beta2-microglobulin-deficient (beta2m-/-) and C57BL/6 (beta2m+/+) mice. Ly49C/I or Ly49A receptor was expressed on NK1.1+gamma/delta T cells but not on NK1.1-gamma/delta T cells. The numbers of NK1.1+gamma/delta T cells were significantly smaller in beta2m+/+ mice than in beta2m-/- mice with the same H-2b genetic background. Among NK1.1+gamma/delta T cells, the proportions of Ly49C/I+ cells but not of Ly49A+ cells, were decreased in beta2m+/+ mice, suggesting that cognate interaction between Ly49C/I and H-2Kb is involved in the reduction of the number of Ly49C/I+ gamma/delta T cells in beta2m+/+ mice. The frequency of Ly49C/I+ cells in NK1.1+gamma/delta T cells was lower in both lethally irradiated beta2m+/+ mice transplanted with bone marrow (BM) from beta2m-/- mice and lethally irradiated beta2m-/- mice transplanted with BM from beta2m+/+ mice than those in adult thymectomized BM-transplanted chimera mice. These results suggest that reduction of Ly49C/I+ NK1.1+gamma/delta T cells in beta2m+/+ mice is at least partly due to the down-modulation by MHC class I molecules on BM-derived haematopoietic cells or radioresistant cells in the thymus.
Chemotherapy Is More Effective in Patients with Breast Cancer Not Expressing Steroid Hormone Receptors (2004)

Response to preoperative chemotherapy is significantly higher for patients with endocrine nonresponsive tumors. New chemotherapy regimens or combinations should be explored in this cohort of patients with poor outcome. For patients with endocrine responsive disease, the role of preoperative endocrine therapies should be studied.
Compositing color with texture for multi-variate visualization (2005)

Multivariate data visualization requires the development of effective techniques for simultaneously conveying multiple different data distributions over a common domain. Although it is easy to successfully use color to represent the value of a single variable at a given location, effectively using color to represent the values of multiple variables at the same point at the same time is a trickier business. In this paper, we provide a comprehensive overview of strategies for effectively combining color with texture to represent multiple values at a single spatial location, and present a new technique for automatically interweaving multiple colors through the structure of an acquired texture pattern.
Long-Term Inhibition of the Central α2B-Adrenergic Receptor Gene Via Recombinant AAV-Delivered Antisense in Hypertensive Rats (2006)

These results indicate that our construct, when given by ICV means, could reach multiple sites of the central nervous system relevant to BP regulation and could safely inhibit the central alpha(2B)-adrenergic receptor, thereby achieving prolonged reversal of salt-induced hypertension.
How do you write and present research well? Q4 – Do not metastasize with metadiscourse (2015)

Abstract In the classic writing style, writers recognize that readers are competent and will recognize the truth as you lead them through your work. Soggy prose seeks “to argue for the truth.” [1] Your text should read like a conversation rather than a lecture. Match each sentence with one of the cardinal sins of writing to the left. [2,3] (Multiple choices possible) 1 Hedging b) In general these results show that a system with zero‐cost identities does not require centralized allocation of identities to encourage cooperation. [4] 2 Signposting f) In this section we shall evaluate the rate of recombination for nonequilibrium conditions. [5] 3 Redundant c) Here we report our new results on the samarium‐arsenide. [6] 4 Self‐conscious, 6 Boosting e) Whether established pests are suitable for attempted eradication is extremely controversial . [7] 5 Narcissism d) More recently researchers have attempted to quantify the effects of anxiety on foreign language learning. [8] 6 Boosting a) These results are extremely significant statistically and compare favorably with validation studies. [9]
MM/RIM: RIM Composites Using Preplaced Reinforcement (1985)

Le moulage de mat (MM pour Mat Molding) est un moulage reactif pour faire des polyisocyanurates renforces de longues fibres de verre. Proprietes
Subscapularis partial tear nodule causing shoulder rotational triggering (2013)

V.
Relativistic basis-set calculations for atoms with Fermi nuclei (1992)

Nuclei are frequently assumed to be spherically symmetric distributions of (positive) charge in atomic calculations. The Fermi distribution function ${\mathrm{\ensuremath{\rho}}}_{0}$/(1+${\mathit{e}}^{(\mathit{r}\mathrm{\ensuremath{-}}\mathit{c})/\mathit{a}}$) models the nuclear ``skin'' in addition to the finite extension of the nuclear charge distribution. It is a popular choice when finite-difference methods are used in calculations of atomic structure because all derivatives of the corresponding potential-energy function are finite and continuous in the region 0r\ensuremath{\infty} when a>0. We investigate such ``Fermi nuclei'' in the context of relativistic basis-set calculations: We present upper limits on the Dirac-Fock and Dirac-Fock-Breit ground-state energies of heliumlike ions with Z=10,20,...,160; we also present a basis-set estimate of the Dirac-Fock energy of the neutral mercury atom.
Evaluation of easily removable pellicle adhesive (2010)

With the advancement of technology, the need to produce flatter photomasks is critical to meet strict mask manufacturing requirements. Components such as pellicle mounting techniques, pellicle frame height, frame material and adhesive all play an important role in finished photomask flatness.1-5 In particular, recent studies have shown that adhesive flexibility affect final photomask flatness significantly.6 This has motivated pellicle suppliers to optimize adhesive properties in addition to evaluate new adhesives. The paper describes the joint evaluations between IBM, Toppan and MLI, performed to determine the effect of a new MLI adhesive on the distortion of photomasks. Due to the nature of this adhesive, minimal mounting force is required. As a result of utilizing extreme low mounting pressure, benefits such as decreased flatness distortion and ease of adhesive removal are observed. The goal of this paper is to evaluate this new adhesive offering and understand the various impacts it has on pelliclized photomasks for advanced technologies.
Solvatochromic comparison method. 20. Linear solvation energy relationships. 12. The d.delta. term in the solvatochromic equations (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvatochromic comparison method. 20. Linear solvation energy relationships. 12. The d.delta. term in the solvatochromic equationsR. W. Taft, Jose-Luis M. Abboud, and Mortimer J. KamletCite this: J. Am. Chem. Soc. 1981, 103, 5, 1080–1086Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://doi.org/10.1021/ja00395a015Request reuse permissionsArticle Views534Altmetric-Citations125LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (710 KB) Get e-Alertsclose Get e-Alerts
A New Approach to Producing Functional Gα Subunits Yields the Activated and Deactivated Structures of Gα<sub>12/13</sub> Proteins (2005)

The oncogenic G(12/13) subfamily of heterotrimeric G proteins transduces extracellular signals that regulate the actin cytoskeleton, cell cycle progression, and gene transcription. Previously, structural analyses of fully functional G alpha(12/13) subunits have been hindered by insufficient amounts of homogeneous, functional protein. Herein, we report that substitution of the N-terminal helix of G alpha(i1) for the corresponding region of G alpha12 or G alpha13 generated soluble chimeric subunits (G alpha(i/12) and G alpha(i/13)) that could be purified in sufficient amounts for crystallographic studies. Each chimera bound guanine nucleotides, G betagamma subunits, and effector proteins and exhibited GAP responses to p115RhoGEF and leukemia-associated RhoGEF. Like their wild-type counterparts, G alpha(i/13), but not G alpha(i/12), stimulated the activity of p115RhoGEF. Crystal structures of the G alpha(i/12) x GDP x AlF4(-) and G alpha(i/13) x GDP complexes were determined using diffraction data extending to 2.9 and 2.0 A, respectively. These structures reveal not only the native structural features of G alpha12 and G alpha13 subunits, which are expected to be important for their interactions with GPCRs and effectors such as G alpha-regulated RhoGEFs, but also novel conformational changes that are likely coupled to GTP hydrolysis in the G alpha(12/13) class of heterotrimeric G proteins.
Relative Long-Term Effects of Spironolactone in Conjunction with an Angiotensin-Converting Enzyme Inhibitor on Left Ventricular Mass and Diastolic Function in Patients with Essential Hypertension. (2002)

It has been reported that treatment with an angiotensin-converting enzyme (ACE) inhibitor is not adequate to suppress aldosterone, and we previously demonstrated that adding spironolactone to an ACE inhibitor may have beneficial effects on left ventricular hypertrophy (LVH) in selected patients with essential hypertension (EH). We have extended our previous short-term study, and addressed the relative long-term clinical effects of spironolactone and an ACE inhibitor in patients with EH who have LVH. Twenty patients with EH and concomitant LVH participated in this study. Subjects were treated with either an ACE inhibitor alone (group 1: 10 patients) or an ACE inhibitor plus spironolactone at the dose of 25 mg (group 2: 10 patients) for 60 weeks. The baseline clinical and echocardiographic characteristics of the two groups were similar. Final values of blood pressure were also similar between the two groups. The LV mass index (LVMI) decreased significantly in both groups, but the extent of reduction was significantly greater in group 2 at 60 weeks. The early peak to atrial peak filling velosities ratio (E/A ratio) was significantly increased to a similar extent in both groups. Serum procollagen type III amino-terminal peptide (PIIINP) was significantly decreased in group 2, but not in group 1. In group 2, there was a statistically significant correlation between the changes in LVMI and PIIINP. In conclusion, adding spironolactone to therapy with an ACE inhibitor for 60 weeks may have beneficial effects in patients with EH and concomitant LVH. Our study strongly suggests the possibility that attenuation of the effects of cardiac aldosterone in patients with EH by treatment with spironolactone and an ACE inhibitor may become a new goal for the prevention and regression of cardiac hypertrophy.
EVIDENCE FOR AUTOREGULATION OF GROWTH HORMONE SECRETION VIA THE CENTRAL NERVOUS SYSTEM (1980)

The ability of growth hormone (GH() to regulate its own secretion at the level of the central nervous system was examined in chronically cannulated freely-moving rats. Six-hour GH secretory profiles were obtained from 2 groups of rats administered either normal saline or rat GH via the lateral ventricle of the brain. The typical pulsatile pattern of GH secretion was evident in normal saline-treated control rats with most peak GH values > 400 ng/ml. Injection of rat GH (15 microgram/10 microliter) resulted in a significant suppression in amplitude of GH secretory pulses after an interval of 1 hour and plasma GH levels remained markedly depressed for up to 6 h after injection. Peak GH values did not exceed 76 ng/ml during the latter 3 h of the sampling period. These findings clearly demonstrate that GH can regulate its own secretion via a negative feedback system. Furthermore, the results suggest that the central nervous system is an important site of action for GH autoregulation.
Ischaemia/Reperfusion Enhances Phenylephrine-Induced Contraction of Rabbit Aorta Due to Impairment of Neuronal Uptake (1994)

We studied the effect of ischaemia and reperfusion on vasoconstrictor and vasodilator mechanisms. Anaesthetized rabbits were subjected to 4-h abdominal aortic occlusion and 1-h reperfusion in vivo. Segments of the abdominal (ischaemic-reperfused) and thoracic (control) aorta were then removed for in vitro studies. Ischaemia/reperfusion had no significant effect on relaxant responses to either acetylcholine (ACh:endothelium-dependent) or sodium nitroprusside (SNP:endothelium-independent). The sensitivity of the aorta to contraction by phenylephrine was significantly increased in aortic rings with or without endothelium (by 2.2- and 3.7-fold, respectively), but was not different after 4-h ischaemia without reperfusion. In contrast, responses to methoxamine, serotonin, and U46619 were not affected by ischaemia/reperfusion. Moreover, the relative increase in aortic sensitivity to phenylephrine was prevented by treatment of control and ischaemic-reperfused aortic rings with the neuronal uptake inhibitor cocaine (10(-5) M). These results suggest that after 4-h ischaemia, reperfusion damages sympathetic neuronal uptake mechanisms in rabbit aorta. As a result, phenylephrine, an agonist normally susceptible to neuronal uptake, may exert more potent contractile effects. Endothelium-dependent and endothelium-independent relaxant mechanisms in the aorta appear to be resistant to acute ischaemia and reperfusion.
High-power self-mode-locked Yb:Y_2O_3 ceramic laser (2007)

We have experimentally demonstrated a high-power self-mode-locked Yb:Y(2)O(3) ceramic laser. Without any additional active or passive element in the cavity, self-started cw mode-locking was achieved. The maximum output power was as high as 2.7 W with a pulse duration of 1.1 ps. Numerical studies show that the diffraction loss induced by thermal lens aberration, in combination with the Kerr self-focusing effect in the gain medium, results in the mode locking of the laser. To our knowledge, this is the first self-mode-locked ceramic laser.
Modeling of Compositional Gas Transport in Shale as a Deformable Porous Medium (2017)

Commercial production from resource shale has been realized largely due to the creation of propped hydraulic fractures in these unconventional resources. However, the pore pressure declines during production, resulting in a decrease in the fracture width and conductivity. This is because of the matrix and proppant deformation, and consequent embedment of proppants in the shale matrix. We present a new mathematical model and simulation framework to model multicomponent advection and molecular diffusion in a deformable shale medium using the control volume finite element method.We use the Maxwell-Stefan diffusion theory to model the composition- and pressure-dependence of molecular diffusion, while we use a continuum with viscoelastic properties to model the stress and time-dependence of the propped fracture conductivity. The study shows that shale-gas well production creates a non-uniform stress field near the fracture surface. This production-induced stress field tends to close the hydraulic fracture and decrease its aperture over time.
PHOTOCHEMISTRY OF PORPHYRINS (thesis) (1953)

optic technology, using light for remote in-situ sensing of groundwater contaminants has become practical. Significant progress has been made in the area of fiber-optic chemical sensors as can be seen by the number of recent review articles. The objective of this work is to develop a remote sensor for real-time measurement of actinides and concentrations in environmental or process waters based on absorption spectroscopy using internal reflection spectroscopy. Porphyrin coated silica wafers were prepared and the sensitivity and selectivity to actinides was determined.
Inorganic materials solution for multi-chip modules and high speed multi-layer hybrids (2005)

As a response to the ever ancreasang demands made on materials for advanced interconnection technologies, a materials system based on etched gold conductors and a new kind of thick film dielectric is being developed. The dielectric is derived from powders, produced from chemical precursors using sol-gel processing techniques, which are dispersed in a photosensitive vehicle. The material offers very low penaittivity (around 4) and, using simple photcprocessing, vias smaller than 25 microns may be resolved. This technology readily lends itself to the production of high density muiti-chip modules and advanced multi-layer Irvbrid circuits, offering both low cost and high reliability.
Performance of Ga/sub 0.47/In/sub 0.53/As cells over a range of proton energies (2002)

Ga/sub 0.47/In/sub 0.53/As space power solar cells were processed by OMVPE and their characteristics determined at proton energies of 0.2, 0.5, and 3 MeV. Emphasis was on characteristics applicable to use of this cell as the low bandgap member of a monolithic, two terminal high efficiency InP/GaInAs cell. It was found that the radiation induced degradation in efficiency, I/sub sc/ V/sub oc/ and diffusion length increased with decreasing proton energy. When efficiency degradations were compared with InP it was observed that the present cells showed considerably more degradation over the entire energy range. Similar to InP, R/sub c/, the carrier removal rate, decreased with increasing proton energy. However, numerical values for R/sub c/ differed from those observed with InP. The difference is attributed to differing defect behavior between the two cell types. It was concluded that particular attention should be paid to the effects of low energy protons especially when the particle's track ends in one cell of the multibandgap device.
Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation (2012)

KRAS mutation is a negative predictive prognostic factor during metastatic colorectal cancer treatment with antiepidermal growth factor receptor antibodies. For affected patients, new therapeutics must be explored. Our objective was to study efficacy of two drugs with different mechanisms of action, everolimus (mTOR inhibitor) and lapatinib (tyrosine kinase inhibitor), in a mouse xenograft model. We chose a model obtained after engraftment of a tumor originating from a human tumor collection. The patient was affected by a metastasis colorectal carcinoma resistant to cetuximab with KRAS mutation. From a previous study in mice, we know that everolimus is a P-glycoprotein (P-gp) substrate and that a lapatinib pretreatment increases significantly (2.6-fold) everolimus AUC by inhibiting its intestinal P-gp efflux. We hence tested the effect of these drugs alone or combined. Mice bearing the xenografts were divided in four groups: control, lapatinib, everolimus, and L/E group (L/E: 2 days of lapatinib 200 mg/kg and then 3 days of everolimus 1 mg/kg). Tumor volumes and treatment toxicities were evaluated. Sixteen days after treatment initiation, the group L/E was the first one in which tumor volume average was significantly lower than the one of control group (193 ± 90 vs. 395 ± 171 mm(3) ; P = 0.0025). After 4 weeks of treatment, inhibition of tumor growth in lapatinib, everolimus, and L/E groups reached, respectively, 49, 53, and 57%. Each drug showed significant antitumor activity. Only moderate hematologic toxicity signs were observed. These results lead to new perspectives for new oral drugs in metastatic KRAS-mutated colorectal cancer resistant to standard chemotherapy.
The aging woman: the role of medical therapy (2003)

The growth of the postmenopausal population demands a change in the medical profession's approach to health and disease. Especially in the developed world, lifespan is increasing, and at the age of 60 the majority of women will still have at least 20 years to live. There will, therefore, be an increasing need for health programs that lead to more years of disability free life. Hormone replacement therapy (HRT) is but one example of the dilemmas medical therapy of the aging woman poses. In the sixties, estrogen was considered a wonder drug, effective for a multitude of postmenopausal problems and illnesses. Recent research has placed this notion into a more balanced perspective, emphasizing that every medical treatment should be based on evidence. It is therefore worrisome if the decline in the use of HRT is followed by an increased use of alternative medicine with mostly undocumented effects.
Multiple p44 Genes Encoding Major Outer Membrane Proteins Are Expressed in the Human Granulocytic Ehrlichiosis Agent (1999)

Human granulocytic ehrlichiosis (HGE) is caused by infection with an obligatory intracellular bacterium, the HGE agent. We previously cloned a gene encoding HGE agent 44-kDa major outer membrane protein and designated it p44. In this study, we (i) identified five different mRNAs that are transcribed from p44-homologous genes in the HGE agent cultivated in HL-60 cells; (ii) cloned genes corresponding to the mRNAs from the genomic DNA of the HGE agent; (iii) showed that the genes being expressed were not clustered in the HGE agent genome; (iv) estimated that a minimum copy number of the p44-homologous genes in the genome is 18; (v) detected two different P44-homologous proteins expressed by the HGE agent; and (vi) demonstrated existence of antibodies specific to the two proteins in sera from patients with HGE. These findings showed that p44 multigenes have several active expression sites and the expression is regulated at transcriptional level, suggesting a potentially unique mechanism for generating the diversity in major antigenic outer membrane proteins of the HGE agent. Characterization of p44-homologous genes expressed by the HGE agent in a tissue culture would assist in understanding a role of the p44 multigene family in pathogenesis and immune response in HGE.
A pattern enforcing compiler (PEC) for Java: using the compiler (2005)

A PEC is a Pattern Enforcing Compiler, which is like a conventional compiler only extended to include the extra checks needed to enforce design patterns. PECs are currently a research project and the PEC written is targeted at the Java programming language. This paper: