gebhart/patrepeval huggingface dataset:
An on-chip short-time interval measurement technique for testing high-speed communication links (2002)

In this paper, we present a BIST scheme for on-chip short-time interval measurement intended for characterizing the time-domain specifications, e.g., the rise/fall time of modern high-speed communication transceivers. To reduce hardware overhead, the proposed BIST technique uses the coherent under-sampling principle, and measures implicitly the time interval in a two-pass manner. Simulation results are shown to validate the proposed technique.
Compact multiplexer formed by coupled resonators with distributed coupling (2005)

Conventionally, the design of microwave multiplexer networks is performed in two steps: first, the filters for each channel are independently synthesized. Second, a power divider or manifold network is designed so that the responses of the isolated filters are minimally affected when integrated into the whole device. Usually this network is formed by lengths of transmission lines that introduce phase shifts to each channel. An additional optimization step of the complete network is carried out in order to further improve the response of each channel. We have followed a different approach. The complete network is formed exclusively by coupled microwave resonators, just like filters but with an arbitrary number of ports. The network is described by means of a generalized coupling matrix, suitable for the increased number of ports. The signal combination is obtained through distributed couplings between the resonators of each channel. As a result, the placement of the non-complete transmission zeros due to the interaction between channels can be controlled and used to increase the selectivity of the multiplexer.
Coherent, atomically thin transition-metal dichalcogenide superlattices with engineered strain (2018)

Epitaxy forms the basis of modern electronics and optoelectronics. We report coherent atomically thin superlattices in which different transition metal dichalcogenide monolayers-despite large lattice mismatches-are repeated and laterally integrated without dislocations within the monolayer plane. Grown by an omnidirectional epitaxy, these superlattices display fully matched lattice constants across heterointerfaces while maintaining an isotropic lattice structure and triangular symmetry. This strong epitaxial strain is precisely engineered via the nanoscale supercell dimensions, thereby enabling broad tuning of the optical properties and producing photoluminescence peak shifts as large as 250 millielectron volts. We present theoretical models to explain this coherent growth and the energetic interplay governing the ripple formation in these strained monolayers. Such coherent superlattices provide building blocks with targeted functionalities at the atomically thin limit.
Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins (2011)

Central nervous system (CNS) involvement remains an important cause of morbidity and mortality in acute leukemia, the mechanisms of leukemic cell infiltration into the CNS have not yet been elucidated. The blood-brain barrier (BBB) makes CNS become a refugee to leukemic cells and serves as a resource of cells that seed extraneural sites. How can the leukemic cells disrupt this barrier and invasive the CNS, even if many of the currently available chemotherapies can not cross the BBB? Tight junction in endothelial cells occupies a central role in the function of the BBB. Except the well known role of degrading extracellular matrix in metastasis of cancer cells, here we show matrix metalloproteinase (MMP)-2 and -9, secreted by leukemic cells, mediate the BBB opening by disrupting tight junction proteins in the CNS leukemia. We demonstrated that leukemic cells impaired tight junction proteins ZO-1, claudin-5 and occludin resulting in increased permeability of the BBB. However, these alterations reduced when MMP-2 and -9 activities were inhibited by RNA interference strategy or by MMP inhibitor GM6001 in an in vitro BBB model. We also found that the disruption of the BBB in company with the down-regulation of ZO-1, claudin-5 and occludin and the up-regulation of MMP-2 and -9 in mouse brain tissues with leukemic cell infiltration by confocal imaging and the assay of in situ gelatin zymography. Besides, GM6001 protected all mice against CNS leukemia. Our findings suggest that the degradation of tight junction proteins ZO-1, claudin-5 and occludin by MMP-2 and -9 secreted by leukemic cells constitutes an important mechanism in the BBB breakdown which contributes to the invasion of leukemic cells to the CNS in acute leukemia.
SYNTHESIS AND INSECTICIDAL ACTIVITY OF NOVEL ACRYLONITRILE DERIVATIVES (1996)

Abstract (E)-3-p-Anisyl-2-cyano-2-propenoyl chloride and/or azide (1b and c) underwent successful nucleopbilic displacement reactions, with urea and thiourea derivatives to give the mono- or di- displacement products (4, 8, 2 and 5) respectively, beside other cyclic products (3 and 6); with aromatic binucleophilies e.g. o-phenylene diamine, the expected di-displacement products (12 and 13) were obtained, while with 2-aminophenol a mixture of two mono-displacement products (15 and 16) were isolated.
The Use of C-14 Labeled Perfluoroöctanoic Acid in the Study of Adhesion and Other Surface Phenomena (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Use of C-14 Labeled Perfluoroöctanoic Acid in the Study of Adhesion and Other Surface PhenomenaJ. W. Shepard and J. P. RyanCite this: J. Phys. Chem. 1956, 60, 1, 127–128Publication Date (Print):January 1, 1956Publication History Published online1 May 2002Published inissue 1 January 1956https://pubs.acs.org/doi/10.1021/j150535a035https://doi.org/10.1021/j150535a035research-articleACS PublicationsRequest reuse permissionsArticle Views25Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles (1999)

Using antibodies against autophagic vacuole membrane proteins we identified a human cDNA with an open reading frame of 1848 bp, encoding a protein of 70 kDa, which we named lysosomal apyrase-like protein of 70 kDa (LALP70). Sequence analysis revealed that LALP70 belongs to the apyrase or GDA1/CD39 family and is almost identical to a human uridine diphosphatase, with the exception of nine extra amino acids in LALP70. Members of this family were originally described as ectoenzymes, with some intracellular exceptions. Transfected LALP70 fused to the green fluorescent protein localized in the cytoplasm with a punctate pattern in the perinuclear space. These structures colocalized with the autophagic marker monodansylcadaverine and the lysosomal protein lamp1. Hydrophobicity analysis of the encoded protein revealed a transmembrane region at the N and C termini. Most of the sequence is arranged between these transmembrane domains, and contains four apyrase conserved regions. In vitro transcription/translation in the presence of microsomes showed that no signal sequence is cleaved off and that the translation product is protected from trypsin treatment. Our data indicate that LALP70 is a type III lysosomal/autophagic vacuole membrane protein with the apyrase conserved regions facing the luminal space of the vacuoles.
How pre-engagement factors and service product attribute complexity impact customer tenure with a retailer (2016)

The purpose of this research is to look at how various cultural dimensions - power distance, uncertainty avoidance, and individualism/collectivism - are related to the actual tenure of a customer with a retail service provider. In addition, how these same culture dimensions impact the selection of a service product based on the complexity of the service product attributes was examined. Additionally, how the complexity of the service product attributes relate directly to customer tenure with the retail service provider was studied. Finally, how the customer's anticipated service quality expectations, another pre-engagement factor, was explored with regard to its impact on the subsequent tenure of the customer with the retail service provider.
SIR-based interference-maps for TDMA-based outdoor mesh networks (2010)

A TDMA-based MAC protocol is essential to achieve high throughput and low delay/jitter values, in WiFi mesh networks. An important component of such a network is the interference map, which quantifies the level of interference between pairs of links in the network. Past work in this domain has been relatively sparse, although many protocols and algorithms have been proposed which assume an interference map. In a TDMA network where carrier-sense is disabled, all interference shows up as hidden-terminal cases. Prior work on building interference maps has not focused on the hidden terminal case. Further, most prior evaluation has been in indoor settings. In this work, we present an SIR based interference measurement technique. We start by measuring the average RSS for each link in the network. This is subsequently used to get an estimated average SIR. The average SIR is then used in conjunction with an SIR-versus-PER plot, to estimate the link error rate under interference. We show through measurements on an outdoor 802.11b/g testbed, that the above estimate is accurate for (1) non-interfering links, as well as (2) fully interfering links, but is less accurate for (3) intermediate link pairs. The resultant 3-way classification of inter-link interference will be useful input for subsequent TDMA scheduling algorithms.
Metadata integration framework for managing forest heterogeneous information resources (2004)

Managing a large number of heterogeneous information sources and repositories, including databases, knowledge bases, file systems, digital library is a general problem faced by many organizations today. In this context, forest Web data sources provide complex query and analysis capabilities such as sequence similarity search engines that need to be integrated as well as the data. In this paper we introduce a framework to provide abilities for accessing and managing, in a metadata integrated manner, multiple forest information resources. Afterwards, the MIFOR (metadata integration for managing forest information resources) prototype is studied and developed as a resource discovery tool to map, convert and harvest metadata from structured and semistructured sources.
Ground-State Enthalpies:  Evaluation of Electronic Structure Approaches with Emphasis on the Density Functional Method (2006)

Ground-state enthalpies, calculated by various electronic structure methods, are compared with experimentally well-established values across a sizable data base of 577 molecules and 15 atoms. With the diversity of species and bonding types available in this compilation it is possible to detect deficiencies that may escape with smaller test sets. The present analysis relying on DAtEF (Data base optimized Atomic Enthalpies of Formation) yields error statistics which relate to reaction enthalpies among the species much more directly than extrapolations based on atomization enthalpies. The evaluation is applied to methods ranging from high level first principles wavefunction calculations to density functionals and to semiempirical approaches. It is found that computationally efficient and broadly applicable density functional methods with relatively small but adequate numerical basis sets can provide ground-state enthalpies within approximately 20 kJ/mol rms (approximately 4.8 kcal/mol). This must be considered an excellent result, as presently only the heaviest available methods appear to provide about a factor of 2 more accuracy as inferred from a subset of the data base used here.
Antimicrobial Therapy in Abdominal Surgery: Precepts and Practices (1991)

Over the past 50 years, important developments have taken place in surgical and antimicrobial aspects of the management of intestinal surgery and intra-abdominal sepsis. Many new pathogens like Clostridium difficile, Helibacter and Ruminococcus have been described, and many new beta-lactam drugs and quinolones have been introduced. Immunological aspects such as T cell factors and interleukins have been shown to play an important role in the pathogenesis of intra-abdominal sepsis. Important new pieces of surgical hardware, sutures, and surgical glues to salvage solid organs were added to the surgical armanentorium. This new book looks at all of these important developments and more. Over 900 articles were reviewed to synthesize the core information for this book. The editors' years of experience in trauma surgery and intra-abdominal sepsis add to the tremendous amount of information found in this book written for physicians, house-staff, and medical students.
Clinical and mycological efficacy of single‐day oral treatment with itraconazole (400 mg) in acute vulvovaginal candidosis (2004)

This study aimed to investigate the effectiveness of single-day oral treatment with itraconazole in acute vulvovaginal candidosis (VVC). Vaginitis was demonstrated by both detection of yeast cells and pseudohyphae formation on microscopic examination of vaginal discharge and mycological culture as well as by the clinical signs and symptoms. Clinical and mycological examinations of the 52 patients were performed before, 1 week (short-term) and 4 weeks (long-term) after single-day oral treatment with itraconazole 200 mg b.i.d. The causative yeast fungi were: Candida albicans (76.9%), C. glabrata (9.6%), C. kefyr (9.6%) and C. krusei (3.9%), respectively. In short- and long-term examinations, clinical cure rates were found to be 61.5% and 90.4%, and mycological cure rates were 63.5% and 90.4%, respectively. Itraconazole was found to be 95.0% effective with C. albicans and 75.0% with other Candida species. It is concluded that treatment of acute VVC with itraconazole is safe and effective in the long-term.
Delayed DNA damage associated with mitotic catastrophe following X-irradiation of HeLa S3 cells<sup>*</sup> (1998)

Partial loss of the radiation G2/M checkpoint is thought to be an early event in cell immortalization. One of the attributes of immortalized cell lines is an increase in susceptibility to induction of genomic instability by clastogenic agents. Recently we have shown that in irradiated HeLa cells cell cycle delays in late S and G2 lead to overaccumulation of cyclin B1 and that enhanced intracellular levels of this positive regulator of the cell cycle is correlated with cyclin-dependent kinase activation, spontaneous premature chromosome condensation and subsequent mitotic catastrophe occurring following irradiation. Previous studies have shown that spontaneous premature chromosome condensation and mitotic catastrophe are independent of apoptosis. This report shows that 40 h following X-irradiation of HeLa S3 cells, and subsequent to mitotic catastrophe, DNA strand breaks appear which are chemically distinct from those initially produced by ionizing radiation. This delayed damage is recognized by terminal transferase and thus involves generation of free 3'-OH ends. Pulse field gel electrophoresis analysis of DNA size distributions shows that DNA fragments of approximately 40 kbp and smaller are produced. As strand breaks produced as a direct result of irradiation are generally repaired within a few hours after exposure to X-rays at the doses used, these results describe a novel mechanism for generation of DNA damage occurring a day or more following irradiation. These results may be pertinent to the understanding of mechanisms underlying the delayed lethal effects of irradiation and may provide an initiating mechanism for radiation-induced genomic instability.
Autocorrelation functions arising in analysis of narrowband systems and their representation in terms of characteristic function (1970)

Three expressions of closely similar form are derived for the autocorrelation functions of the envelope, the result of hard limiting, and the instantaneous frequency of a general narrow-band signal. The characteristic function of probability theory links the analysis, and the result that pertains to the instantaneous frequency is thought to be new.
[Construction and identification of an immune single chain antibody library derived from a chicken]. (2007)

An immune single chain antibody library derived from a chicken can be constructed successfully based on the principle of phage antibody library and the character of chicken antibody genes.
NeuFuz: the integration of fuzzy logic and neural nets offers designers tremendous application advantage - today (2002)

A new technology combines the best features of two forefront technologies-neural net and fuzzy logic-into a hybrid that eliminates the drawbacks of each singular technology. Dubbed "NeuFuz" this technology relies on neural nets to learn a systems's behavior using system input-output data, then automatically generates fuzzy rules and membership functions from the learned system knowledge. Once an optimized solution is derived, NeuFuz converts it into either standard C code or assembly language code for an embedded processor. NeuFuz can provide significant advantages in complex applications such as object, pattern or voice recognition; language processing, traffic management and even weather forecasting. The technology reduces design time and significantly improves system performance, accuracy and reliability. A fuzzy rule verifier verifies the solution and optimizes the number of rules and membership functions. The adaptation capability of NeuFuz helps it learn from experience and change fuzzy rules and membership functions accordingly. This paper discusses the benefits of the NeuFuz technology, its implementation and the types of applications.
Flexible and Programmable Evolved Packet Core: A New SDN-based Model (2014)

The mobile core network experienced many transformations during the past decade and at this moment virtualisation constitutes the next big phase in the operators strategies. Another technology which might step in the coming years is Software Defined Networking (SDN), a more mature technology in data centers, which strives to revolutionize the current Long-Term Evolution (LTE) architecture. However, the integration of SDN components into the legacy network and the transition between phases need to be carefully addressed. This thesis aims to develop a new Evolved Packet Core (EPC) (the core network corresponding to the LTE radio network) SDN-based architecture and to take into consideration the challenges that this technology might bring to the mobile core. Therefore, a thorough assessment of the interfaces and protocols that should be preserved or modified on both the user and control planes is investigated. By describing the simulation details of the proposed architecture, one of this thesis goals is to present the trade-off between preserving the traditional 3rd Generation Partnership Project (3GPP) architecture and the actual benefits, along with the challenges for mobile operators in adopting SDN and Network Function Virtualisation (NFV) in their deployments. To achieve this, two testbeds are used: one based on a network emulation tool and another one using physical elements. The obtained results emphasize the flexibility in deploying such solutions. Furthermore, a detailed comparison of two SDN controllers performances is presented. In order to fully benefit of the flexibility of NFV and SDN in their networks, mobile operators should have an overview of the different tools and technologies, which might allow SDN integration in their networks. Another thesis goal is to provide the necessary information in order to give operators the input for building their roadmap to the upcoming technologies.
A Massive Memory Machine (1984)

This paper argues the case for a computer with massive amounts of primary storage, on the order of tens of billions of bytes. We argue that such a machine, even with a relatively slow processor, can outperform all other super-computers on memory bound computations. This machine would be simple to program. In addition, it could lead to new and highly efficient programs which traded the available space for running time. We present a novel architecture for such a machine, and show how it can lead to reduced memory access times and higher reliability.
Population and environment: an Australian challenge. (1992)

The latest UN population projections are cause both for hope and for despair. If effective family planning programs could be implemented without delay in those areas of the world where contraceptives are used by only a minority of the population, then the global population might increase by a mere 2.4 billion people by 2050, and thereafter would decline to 6.4 billion by the end of the next century. A more realistic projection is that numbers will increase to 11.2 billion by the year 2100. But if the issue is ignored, then there will be a global population of 17.6 billion by the century's end. The recent immigration debate and the Government Report on Population Issues and Australia's Future published in early 1992 could be taken as a starting point, even though there is no suggestion in the report that Australia should ever aim to stabilize its own population. The committee was strongly of the view that immigration was an ineffective and inappropriate tool to reduce mass population pressures in other parts of the world. Clearly Australia cannot act as a safety valve for the population excesses in the rest of the world. Even without immigration the present population of 17 million will grow by about another 2 million over the next 40 years as a result of natural increase. If the current level of about 111,000 migrants a year is maintained, Australia's population will grow to 25 million by 2031. The solution is to transfer some of the defense budget to the Australian International Development Assistance Bureau and provide Asian neighbors, whose family planning programs are starved of support, with the weapons they need to fight the population battle. The Population Issues Committee itself recognized that there was a clear need for Australia to develop an enhanced foreign aid program to support family planning services. By doing so Australia would earn the lasting gratitude of Asian neighbors.
FEW phone file system (2009)

Trabalho apresentado no âmbito do Mestrado em Engenharia Informática, como requisito parcial para obtenção do grau de Mestre em Engenharia Informática
Microinjection of Mouse Eggs (1966)

A technique has been developed for injecting known amounts of liquids into fertilized one-celled mouse eggs by use of a calibrated ocular micrometer superimposed on the terminal regions of the injection pipette. From 128 pronuclear eggs, each injected with 180 or 770 cubic microns of bovine gamma globulin at a concentration of 25 milligrams per milliliter in citrate-Locke's solution and then transferred to the oviducts of pregnant foster mothers, 18 living fetuses developed; from 74 eggs, each injected with 2730 cubic microns, 5 fetuses survived. The living fetuses that developed from the injected eggs were smaller than normal in 6 of 23 surviving experimental fetuses as contrasted to only 1 of 19 control fetuses.