gebhart/patrepeval huggingface dataset:
Castanospermine vs. Its 6-O-Butanoyl Analog (1991)

Summary Inhibitors of glycoprotein processing, such as castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine), have been shown previously to inhibit human immunodeficiency virus type 1 (HIV-1) with acceptable toxicity in cultured human cells. In prior experiments, we have tested the toxicity and antiviral efficacy of castanospermine in mice infected with the Rauscher murine leukemia virus (RLV). When compared with 3‘-azido-3’-deoxythymidine (AZT, zidovudine), castanospermine was less effective and more toxic. Since the 6-O-butanoyl analog of castanospermine was previously found to have a more favorable activity profile than the parent compound against HIV-1 in cultured cells, we compared the antiviral efficacy of both compounds in parallel in vitro and in vivo in the RLV system. Plaque formation in the XC assay was inhibited with a 50% inhibitory concentration (IC50) of 2.4 μM for the 6-O-butanoyl analog of castanospermine, as compared to 9 μM for castanospermine. For both compounds, concentrations resulting in significant cytotoxicity were about ten times higher. Both compounds significantly decreased HIV-1 env-induced syncytium formation in a novel in vitro assay. In RLV-exposed mice, the 6-O-butanoyl analog showed no advantage over the parent compound: both curves for toxicity as well as antiviral efficacy were super-imposable. We conclude that the 6-O-butanoyl analog of castanospermine as well as castanospermine itself are active antiviral agents in mice and that prolonged oral administration is tolerable. However, in comparison to AZT, their antiviral activity profiles are less favorable.
A Study on Diffusive-Thermal and Buoyancy-driven Instabilities in Laminar Free-jet Flames with applied DC electric fields (2011)

Self-excitations in horizontally and vertically injected laminar free-jet flames with applied DC electric fields are experimentally investigated and distinctly classified into three: a buoyancyinduced self-excitation due to a flame flicker, a Lewis-number-induced self-excitation, and the fundamental mode as well as their overtones of a derived buoyancy-induced selfexcitation. The application of DC electric fields to jet flames was experimentally designed to suppress heat-loss-induced self-excitations to highlight the definite difference between Lewisnumber-induced self-excitation and the derived buoyancy-induced self-excitation with the same order of 1 Hz. The current study presents the distinct regimes of those distinct selfexcitation modes in the flame stability maps for vertically and horizontally injected jet flames. The results show that the buoyancy-induced self-excitation with O(10) Hz due to a flame flicker causes the frequencies of the fundamental mode with O(1) Hz as well as their overtones of a derived buoyancy-induced self-excitation. Once the buoyancy-induced selfexcitation with O(1) Hz is derived, the mode suppresses Lewis-number-induced selfexcitation. The characteristics between the Lewis-number-induced and the derived buoyancyinduced self-excitation are compared and discussed in detail. The individual phase diagrams in the distinct regimes are presented, and thereby the individual key feature for the abovementioned self-excitations is also highlighted.
13: From Outsiders to Insiders (2013)

We assess graduate assistant competency in key skills that employers in and outside of academia value and examine whether these skills are developed in the context of the graduate assistantship (CA) at a specific state comprehensive university. The GAs in our sample rate themselves as competent or very competent on all skills and report their GA experience somewhat influenced or influenced their skill competencies. Furthermore, perception of how one's graduate assistantship influenced skill competency was significantly associated with perceived skill competency level. Based on these findings, we qiscuss distinct gaps that could be addressed to facilitate GA development at state comprehensive universities.
A PRECLINICAL COMPARISON OF TUMOR THERAPY AND MYELOTOXICITY FOR MU-9 ANTI-CSAp INTACT IgG AND FRAGMENTS LABELED WITH 1–131, Y-90 OR Re-188 (1994)

s: Fifth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer: Session VI: Experimental Radioimmunotherapy: PDF Only
Multiple forms of uridine kinase in normal and neoplastic rat liver (1971)

Two species of uridine kinase with molecular weights of approximately 120000 (I) and 30000 (II) have been identified in the rat liver system. Species I predominates in the 7-day postnatal and adult rat liver and increases in the regenerating remnant of the latter after partial hepatectomy; the concentration of species II is low in these tissues. Species I also predominates in the slow-growing hepatomas 5123D and 7800. In contrast, II is the predominant form in the foetal rat liver and accounts for 40% of the total activity in the rapidly growing Novikoff ascites hepatoma. In contrast to species II, which was stable, species I was inactivated by preincubation for 30min at 37 degrees C, before assay at 23 degrees C.
Three-dimensional gravity instability derived from two-dimensional solutions (1966)

Abstract The theory of three-dimensional gravity instability of multilayers is developed with particular application to salt structures. It is shown that three-dimensional solutions are immediately obtained without further numerical work from the solution of the corresponding two-dimensional problem. Application to a number of typical three-dimensional structures yields the characteristic distance between peaks and crests and shows that this distance does not differ significantly from the wavelength of the two-dimensional solution. Various periodic patterns are examined corresponding to rectangular and hexagonal cells. The time history of nonperiodic structures corresponding to initial deviations from perfect horizontality is also derived. The method is applied to the three-dimensional problem of generation of salt structures when the time-history of sedimentation is taken into account with variable thickness and compaction of the overburden and establishes the general validity of the geological conclusions derived from the previous two-dimensional treatment of the same problem (Biot and Ode, 1965). The present method of deriving three-dimensional solutions, which is developed here in the special context of gravity instability, is valid for a wide variety of problems in theoretical physics.
An automated consultant for MACSYMA (1977)

A consultant is necessary whenever on is faced with a problem solving situation in a domain one does not fully understand. The lack of knowledge may be incidental, as it is when the domain or device is fairly simple but time constraints make it impossible for the user to learn all that is necessary. Computer systems like MACSYMA in which the level of commands is so close to the level of the task environment that the user is apt to confuse a simply defined procedure (like COEFF) with its mathematical counterpart (here coefficient) that it at best approximates. A computer program is described which has the capability of conversing with its user in English about a difficulty he has encountered, and providing information tailored to his need. The MACSYMA Advisor is a program distinct from MACSYMA with its own separate data base and expertise. For convenience the program can be called directly from MACSYMA and can access the user's data structures contained therein. The Advisor described here deals only with the straightline or nested use of MACSYMA commands and not loops or user-defined functions. The implementation of the Advisor relies heavily on an explict, internal model of the user's state of knowledge, his goals, and his plan for achieving them.
Tuning of Group Type Unidirectional Transducers (1979)

Abstroct-A simple tuning network is presented for tuning of group type unidirectional transducers. The method of tuning described uses a maximum of two elements and in special cases requires only a siigle external element. Experimental results for a filter having a 6.3dB insertion loss and a triple transit echo suppressed -44 dB using the described method verifies the analysis.
Dual Role of the Trps1 Transcription Factor in Dentin Mineralization (2014)

TRPS1 (tricho-rhino-phalangeal syndrome) is a unique GATA-type transcription factor that acts as a transcriptional repressor. TRPS1 deficiency and dysregulated TRPS1 expression result in skeletal and dental abnormalities implicating TRPS1 in endochondral bone formation and tooth development. Moreover, patients with tricho-rhino-phalangeal syndrome frequently present with low bone mass indicating TRPS1 involvement in bone homeostasis. In addition, our previous data demonstrated accelerated mineralization of the perichondrium in Trps1 mutant mice and impaired dentin mineralization in Col1a1-Trps1 transgenic mice, implicating Trps1 in the mineralization process. To understand the role of Trps1 in the differentiation and function of cells producing mineralized matrix, we used a preodontoblastic cell line as a model of dentin mineralization. We generated both Trps1-deficient and Trps1-overexpressing stable cell lines and analyzed the progression of mineralization by alkaline phosphatase and alizarin red staining. As predicted, based on our previous in vivo data, delayed and decreased mineralization of Trps1-overexpressing odontoblastic cells was observed when compared with control cells. This was associated with down-regulation of genes regulating phosphate homeostasis. Interestingly, Trps1-deficient cells lost the ability to mineralize and demonstrated decreased expression of several genes critical for initiating the mineralization process, including Alpl and Phospho1. Based on these data, we have concluded that Trps1 serves two critical and context-dependent functions in odontoblast-regulated mineralization as follows: 1) Trps1 is required for odontoblast maturation by supporting expression of genes crucial for initiating the mineralization process, and 2) Trps1 represses the function of mature cells and, consequently, restricts the extent of extracellular matrix mineralization.
Robustness of Digital Circuits at Lower Voltages (2018)

This chapter deals with the robustness of digital circuits in relation to the continuous scaling process. It covers most topics related to signal integrity as well as such reliability issues as electromigration, electro–static discharge, latch–up, hot–carrier effect, and negative temperature bias instability. The digital circuits are responsible for most of this bounce, while the analog circuits are most sensitive to it. The use of a silicon–on–insulator technology allows even a complete separation of the analog and digital circuits. Substrate noise is closely related to the ground bounce. The scaling requires a change in many of these parameters and therefore have dramatic effects on the reliability of complementary metal-oxide semiconductor (CMOS) devices and circuits. The scaling process over that period was called constant–voltage scaling. This scaling scenario will be referred to as constant–size scaling. It is obvious that these different scaling scenarios have a different impact on the basic transistor parameters and on the performance and robustness of CMOS integrated circuits.
A family of lapped regular transforms with integer coefficients (2002)

Invertible transforms with integer coefficients are highly desirable because of their fast, efficient, VLSI-suitable implementations and their lossless coding capability. In this paper, a large class of lapped regular transforms with integer coefficients (ILT) is presented. Regularity constraints are also taken into account to provide smoother reconstructed signals. In other words, this ILT family can be considered to be an M-band biorthogonal wavelet with integer coefficients. The ILT also possesses a fast and efficient lattice that structurally enforces both linear-phase and exact reconstruction properties. Preliminary image coding experiments show that the ILT yields comparable objective and subjective performance to those of popular state-of-the-art transforms with floating-point coefficients.
Vascular Endothelial Growth Factor-B Promotes In Vivo Angiogenesis (2003)

Vascular endothelial growth factors (VEGFs) and their receptors have emerged as central regulators of the angiogenic process. However, involvement of VEGF-B, one of these factors, in angiogenesis remains obscure. Mice received subcutaneous injection of Matrigel alone or Matrigel with human recombinant protein rhVEGF-B167 or with rhVEGF-A165. After 14 days, cell ingrowth in the Matrigel plug was increased by 2.0- and 2.5-fold in rhVEGF-B167-treated and rhVEGF-A165-treated mice, respectively (P<0.01), in association with a raise in phospho-Akt/Akt (1.8-fold, P<0.01) and endothelial NO synthase (eNOS) (1.80- and 1.60-fold, respectively; P<0.05) protein levels measured by Western blot. VEGF-B-induced cell ingrowth was impaired by treatment with NOS inhibitor (NG-nitro-l-arginine methyl ester; L-NAME, 10 mg/kg per day). Treatment with neutralizing antibody directed against the VEGF-B receptor VEGF-R1 (anti-VEGFR1, 10 microg) completely abrogated VEGF-B-related effects. Proangiogenic effect of VEGF-B was confirmed in a mouse model of surgically induced hindlimb ischemia. Plasmids containing human form of VEGF-A (phVEGF-A165) or VEGF-B (phVEGF-B167 or phVEGF-B186) were administered by in vivo electrotransfer. Angiographic score at day 28 showed significant improvement in ischemic/nonischemic leg ratio by 1.4- and 1.5-fold in mice treated with phVEGF-B167 and phVEGF-B186, respectively (P<0.05). Laser Doppler perfusion data also evidenced a 1.5-fold increase in phVEGF-B167-treated and phVEGF-B186-treated mice (P<0.05). Such an effect was associated with an upregulation of phospho-Akt/Akt and eNOS protein levels in the ischemic legs and was hampered by treatment with anti-VEGFR1. This study demonstrates for the first time that VEGF-B, in part through its receptor VEGF-R1, promotes angiogenesis in association with an activation of Akt and eNOS-related pathways.
Buffer memory requirements in DSP applications (2002)

Studies synchronous multi-rate data flow graphs to determine the minimal required buffer sizes that still guarantee the construction of a deadlock-free static schedule. We develop a rule to quickly analyze a graph's consistency. A graph is split up into single and parallel paths. Single paths are analysed, as well as the most frequent parallel paths. The results are used in the rapid prototyping environment GRAPE-II in the case where the emulation hardware contains FPGAs, or when memory is critical.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Controversies, Clarifications, and Consequences of Divorce's Legacy: Introduction to the Special Collection (2003)

Recent publications describing long‐term results of longitudinal investigations of divorced couples have stirred controversies because of substantial differences in findings. The current Special Collection was initiated to clarify some of the issues brought into controversy. Five primary themes are explored by the nine papers in this collection: How severe is the long‐term effect of divorce on children? Why do various research findings on the long‐term effect of divorce tend to disagree so substantially? Why is divorce considered a problem? What do children have to say about their experiences with divorce? And what, if anything, can be done to help the children of divorce?
Images in vascular medicine (2002)

A 69-year-old white male, with a history of hypertension and hypercholesterolemia, presented with a complaint of left, lower quadrant, abdominal pain that radiated to the back, which he had suffered for 2 weeks. The discomfort was most prominent in the seated position and improved with standing or lying down. An abdominal CT scan revealed a 4-cm diameter splenic artery aneurysm (Panel A; arrow). A subsequent angiogram con rmed the presence of a fusiform splenic artery aneurysm measuring 4 cm at its greatest diameter and beginning just distal to the splenic artery origin at the celiac axis (left arrow) and extending to the level of the splenic hilum (right arrow) (Panel B). The patient underwent successful operative obliteration of the aneurysm and splenectomy, since the aneurysm extended into the splenic hilum. Splenic artery aneurysm is rare, with an incidence ranging from 1.6% in an unselected autopsy population to 7.1% in autopsies performed on patients with cirrhotic portal hypertension. However, splenic artery aneurysm is the the most common aneurysm of the visceral arteries, with an average size of 2.10 cm but rarely exceeding 3 cm. Two factors contributing to its formation are weakness of the arterial wall and a concomitant rise in blood pressure. The arterial wall is sensitive to the hormonal effects and hemodynamic stresses of pregnancy, especially in multiparous women and those with pre-existing  bromuscular dysplasia. Atherosclerosis may occur and is thought to be a Department of Medicine, Cardiovascular Division and Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Enhanced Scale-Inhibitor Treatments With the Addition of Zinc (2009)

Summary This paper discusses research on scale inhibition and squeeze performance in the presence of Zn2+. Some scale inhibitors, such as bis-hexamethylenetriamine penta(phosphonic acid), BHPMP, and polymeric inhibitors, such as phosphinopolycarboxylate (PPCA), have poor retention characteristics in conventional squeeze treatment, where less than 50% of the inhibitor is retained in the formation. In this study, it was demonstrated that more than 90% of the same scale inhibitor was retained when Zn2+ was included in the squeeze formulation. Furthermore, Zn2+ showed significant synergistic effect on barite scale inhibition with certain amino-pentaphosphonate scale inhibitors [BHPMP and diethylenetrimine pentaphophonic acid (DTPMP)]. Stronger solution complexes are observed for aminophosphonates type scale inhibitors with Zn2+ than that with alkaline earth metal ions, such as Ca2+, Mg2+, and Ba2+. This stronger solution complex formation with Zn2+ may be attributed to the observed enhanced inhibition efficiency. Because of the lower solubility of Zn2+-scale inhibitor salts, Zn2+ added to the inhibitor pill significantly improves the retention of some scale inhibitors during squeeze treatment. In this paper, the projected squeeze life (PSL) is defined. When Zn2+ is used in the inhibitor pill, the PSL for BHPMP is increased by a factor of 60 without significantly affecting the cost. Simulation indicates that the squeeze life may be improved significantly at the Guerra well if this new squeeze procedure is used.
Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase (2007)

This result demonstrates that 2-[(125)I]iodo-CP-118,954 may be unsuitable for AChE imaging. These findings suggest that radioligands suitable for AChE imaging should have not only a specific structure but also a sub-nanomolar to low nanomolar IC50.
Modeling TCE Dynamics in Water Distribution Tanks (1999)

The paper presents a method to determine the concentration of TCE in a water distribution tank given the influent TCE concentration and the tank fill and drain rates. It then shows how to approximate this solution in the EPANET model.
Biophotonics (2005)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Jesper Glückstad, Ivan Perch-Nielsen, Peter John Rodrigo, Samarendra Kumar Mohanty, Mrinalini Sharma, Mitradas Panicker, Pradeep Kumar Gupta, Caitriona M. Creely, Gajendra P. Singh, Giovanni Volpe, and Dmitri V. Petrov, "Biophotonics," Optics & Photonics News 16(12), 18-20 (2005) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Audio signals in domestic appliances evaluated in terms of the hearing ability of older adults (1998)

The audio signals used in domestic appliances currently available on the market in Japan were recorded to identify suitable signals for the hearing ability of older adults. The results of the analysis indicated the following three problems: (1) Some appliances use high-frequency tones around 4000 Hz. Since these sounds are hard for older adults with presbycusis to hear, it would be better to use signals with lower frequencies. However, the problem here is that if the frequency is lowered, then the signal might be masked by domestic sounds whose power would be greater relative to the low-frequency signals. (2) The signals used by some appliances are too soft. The intensity of some signals should be adjusted to compensate for the hearing loss among older adults. (3) The sounds used in these appliances are often very similar in terms of both timbre and temporal ringing patterns. That may cause confusion because it is difficult to identify which appliance is signaling.
Growth over nonplanar substrates by organometallic molecular-beam epitaxy (1992)

We present the growth habits of GaAs and InGaAs quantum wells grown by organometallic-molecular-beam epitaxy (OM-MBE) on (100) GaAs substrates with micron-range corrugations aligned along the [011̄] direction. The growth habits resemble those obtained by molecular-beam epitaxy, but with several obvious differences, which are discussed on the basis of their different growth mechanisms. These differences reduce the importance of the geometric factors for OM-MBE which dominate in MBE. We observe lateral compositional variations in the InGaAs quantum well. The patterned samples exhibit enhanced luminescence efficiency compared to reference flat samples.
COMPRESSION AND CLASSIFICATION OF IMAGERY (2006)

Problems at the intersection of compression and statistical inference recur frequently due to the concurrent use of signal and image compression and classification algorithms in many applications. This dissertation addresses two such problems: statistical inference on compressed data, and rate-allocation for joint compression and classification.Features of the JPEG2000 standard make possible the development of computationally efficient algorithms to achieve such a goal for imagery compressed using this standard. We propose the use of the information content (IC) of wavelet subbands, defined as the number of bytes that the JPEG2000 encoder spends to compress the subbands, for content analysis. Applying statistical learning frameworks for detection and classification, we present experimental results for compressed-domain texture image classification and cut detection in video. Our results indicate that reasonable performance can be achieved, while saving computational and bandwidth resources. IC features can also be used for preliminary analysis in the compressed domain to identify candidates for further analysis in the decompressed domain.In many applications of image compression, the compressed image is to be presented to human observers and statistical decision-making systems. In such applications, the fidelity criterion with respect to which the image is compressed must be selected to strike an appropriate compromise between the (possibly conflicting) image quality criteria for the human and machine observers. We present tractable distortion measures based on the Bhattacharyya distance (BD) and a new upper bound on the quantized probability of error that make possible closed form expressions for rate allocation to image subbands and show their efficacy in maintaining the aforementioned balance between compression and classification. The new bound offers two advantages over the BD in that it yields closed-form solutions for rate-allocation in problems involving correlated sources and more than two classes.