gebhart/patrepeval huggingface dataset:
The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities (2012)

Centrosome amplification and chromosome abnormality are frequently identified in neoplasia and tumorigenesis. However, the mechanisms underlying these defects remain unclear. We here identify that MCT-1 is a centrosomal oncoprotein involved in mitosis. Knockdown of MCT-1 protein results in intercellular bridging, chromosome mis-congregation, cytokinesis delay, and mitotic death. Introduction of MCT-1 oncogene into the p53 deficient cells (MCT-1-p53), the mitotic checkpoint kinases and proteins are deregulated synergistically. These biochemical alterations are accompanied with increased frequencies of cytokinesis failure, multi-nucleation, and centrosome amplification in subsequent cell cycle. As a result, the incidences of polyploidy and aneuploidy are progressively induced by prolonged cell cultivation or further promoted by sustained spindle damage on MCT-1-p53 background. These data show that the oncoprotein perturbs centrosome structure and mitotic progression, which provide the molecular aspect of chromsomal abnormality in vitro and the information for understanding the stepwise progression of tumors under oncogenic stress.
CSF amyloid‐β 1‐38 and 1‐42 in FTD and AD: Biomarker performance critically depends on the detergent accessible fraction (2008)

Cerebrospinal fluid (CSF) Aβ1-38, Aβ1-40, and Aβ1-42 were comparatively analyzed by amyloid-beta SDS-PAGE with Western immunoblot (Aβ-SDS-PAGE/immunoblot), electrochemiluminescence detection and ELISA (MSD/ELISA) in patients with Alzheimer's disease (AD, n = 40), frontotemporal dementia (FTD, n = 30), and other dementias (n = 50) and nondemented disease controls (n = 30). CSF Aβ-peptide concentrations were higher and selective decreases of CSF Aβ1-38 in FTD and Aβ1-42 in AD were more evident as measured after SDS-denaturizing of samples by Aβ-SDS-PAGE/immunoblot. The SDS-accessible pool of CSF Aβ1-38 and Aβ1-42, represented by the individual gain of Aβ-peptide yield using Aβ-SDS-PAGE/immunoblot, was reduced in both FTD and AD. Accordingly, biomarker accuracies of Aβ1-38 and Aβ1-42 for detection of FTD and AD, respectively declined as determined by MSD/ELISA. We conclude that a pool of CSF Aβ1-38 and Aβ1-42, which shows disease-specific reductions in FTD and AD, may be bound to carriers and can be released by SDS. Assessing this SDS-accessible Aβ-peptide pool may crucially enhance the accuracy of CSF biomarker tests. Identifying disease-specific binding properties of affected Aβ carriers may elucidate pathogenic aspects and open up a novel field for therapeutic approaches.
Effects of Desferrioxamine on 67Ga Distributions in Tumor-Bearing Mice (1979)

The iron-chelating agent desferrioxamine caused approximately 10-fold reductions in 67Ga vascular concentrations and substantial (~ × 2) reductions in 67Ga concentrations of other tissues when injected iv into mice at 2 hr after 67Ga injection. Given 48 hr post 67Ga however, its only noteworthy effect was on the vascular compartment. Tumor was distinguished from other soft tissues by high concentrations of cell-bound 67Ga, of which an appreciable fraction could be chelated and cleared by desferrioxamine given 2 hr after 67Ga. This fraction diminished with time and, at 48 hr, desferrioxamine caused no significant clearance of tumor-bound 67Ga.
Rheological Properties of Hemoglobin Vesicles (Artificial Oxygen Carriers) Suspended in a Series of Plasma-Substitute Solutions (2007)

Hemoglobin vesicles (HbV) or liposome-encapsulated Hbs are artificial oxygen carriers that have been developed for use as transfusion alternatives. The extremely high concentration of the HbV suspension (solutes, ca. 16 g/dL; volume fraction, ca. 40 vol %) gives it an oxygen-carrying capacity that is comparable to that of blood. The HbV suspension does not possess a colloid osmotic pressure. Therefore, HbV must be suspended in or co-injected with an aqueous solution of a plasma substitute (water-soluble polymer), which might interact with HbV. This article describes our study of the rheological properties of HbV suspended in a series of plasma substitute solutions of various molecular weights: recombinant human serum albumin (rHSA), dextran (DEX), modified fluid gelatin (MFG), and hydroxylethyl starch (HES). The HbV suspended in rHSA was nearly Newtonian. Other polymers-HES, DEX, and MFG-induced HbV flocculation, possibly by depletion interaction, and rendered the suspensions as non-Newtonian with a shear-thinning profile (10(-4)-10(3) s(-1)). These HbV suspensions showed a high storage modulus (G') because of the presence of flocculated HbV. However, HbV suspended in rHSA exhibited a very low G'. The viscosities of HbV suspended in DEX, MFG, and high-molecular-weight HES solutions responded quickly to rapid step changes in shear rates of 0.1-100 s(-1) and a return to 0.1 s(-1), indicating that flocculation is both rapid and reversible. Microscopically, the flow pattern of the flocculated HbV that perfused through microchannels (4.5 microm deep, 7 microm wide, 20 cmH2O applied pressure) showed no plugging. Furthermore, the time required for passage was simply proportional to the viscosity. Collectively, the HbV suspension viscosity was influenced by the presence of plasma substitutes. The HbV suspension provides a unique opportunity to manipulate rheological properties for various clinical applications in addition to its use as a transfusion alternative.
Untersuchungen zur Bildung wasserlöslicher Cellulosephosphate durch homogene Acylierung im System Cellulose N<sub>2</sub>O<sub>4</sub>/DMF. 1. Mitt.: Problemstellung und Ergebnisse zur Acylierung mit POCl<sub>3</sub> (1991)

Abstract Nach Auflösung in einem N 2 O 4 /DMF‐Gemisch unter partieller Bildung des Nitritesters wurde Cellulose unter homogenen Reaktionsbedingungen mit POCl 3 in Gegenwart von Triethylamin bis zu DS p ‐Werten von etwa 1 phosphoryliert. Wasserlösliche Produkte wurden im DS p ‐Bereich zwischen 0,3 und 0,6 nach einer Behandlung des Reaktionsproduktes in einem protischen Medium erhalten.
Null ellipsometer with phase modulation (2004)

A new null ellipsometer is described that uses photoelastic modulator (PEM). The phase modulation adds a good signal-to-noise ratio, high sensitivity, and linearity near null positions to the traditional high-precision nulling system. The ellipsometric angles Delta and psi are obtained by azimuth measurement of the analyzer and the polarizer-PEM system, for which the first and second harmonics of modulator frequency cross the zeros. We show that the null system is insensitive to ellipsometer misadjustment and component imperfections and modulator calibration is not needed. In addition, a fast ellipsometer mode for fine changes measurement of ellipsometric angles is proposed.
Interferon‐γ, but Not Interleukin‐4, Suppresses Experimental Polymyositis (2016)

Our findings indicate that IFNγ, but not IL-4, plays a suppressive role in the development of CIM. Unlike in CD4+ T cell-mediated autoimmune disease models, IFNγ prevents factors other than IL-17A from exacerbating myositis and neutrophil infiltration in CD8+ T cell-mediated CIM.
235 * AN EXPANSIBLE AORTIC RING TO PRESERVE ROOT DYNAMICS AFTER AORTIC VALVE REPAIR (2013)

Objectives: Aortic annuloplasty and preservation of root dynamics have been described as factors in the durability of aortic valve repair. The objective of this study is to document the first clinical analysis of root dynamics after a standardized valve-sparing procedure for root aneurysms associating a calibrated expansible external aortic ring annuloplasty (ExtraAortic, Coroneo Inc) with a physiological remodelling of the aortic root (CAVIAAR technique). Methods: Among 310 patients operated on with the CAVIAAR technique, 61 patients from a single team underwent double independent reading of the echocardiographic analysis performed during the operative period and yearly after discharge. Preoperative aortic insufficiency (AI) ≥grade 2 was found in 51 cases (83.6%) and 34 (55.7%) had bicuspid valves. Results: The expansible aortic ring (26 ± 2 mm) significantly reduced the aortic annular base diameter (from 27.20 ± 3.41 mm to 22.95 ± 2.21 mm, P < 0.01) without significant mean transvalvular gradient (7 ± 3.3 mmHg). At a mean of 22 ± 17 (3-64) months follow-up, annular diameter and cusp effective height (9.4 ± 3.45 mm) remained stable. AI was grade ≤1 in 57 cases (93.4%). There were no deaths or reoperation. Root expansibility was maintained in the pre- and postoperative periods and at last follow-up, independently of age and presence of bicuspid valve: it was respectively 5.93%, 6.35%, and 8.35% at the aortic annular base level, and 2.5%, 2.11%, and 3.74% at the sinuses of Valsalva level (P < 0.01). Conclusions: The expansible aortic ring achieved a complete calibrated external annuloplasty and maintained dynamics of the aortic root at mid-term follow-up. Whether this could be a factor in the durability of aortic valve repair is currently under evaluation through the CAVIAAR study 10-year follow-up.
A knowledge-based approach to dead-time estimation for process control, with real-time application to a coupled-tank system (2002)

Knowledge-based approaches are increasingly becoming widespread in process control engineering as they provide a more comprehensive approach to industrial control than the traditional methods based entirely on algorithmic methods. In fact, it is more common now to view algorithmic methods as simply a component of a more comprehensive knowledge-based strategy. In this paper, we consider the development of a knowledge-based approach to provide an estimation procedure for the dead-time in industrial processes. This development forms a module within a larger project for development of an intelligent knowledge-based process controller.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A novel curvilinear approach for prostate seed implantation (2012)

Significant improvement in the relevant dosimetric parameters was observed in curvilinear needle approach. Prostate dose homogeneity (V(150), V(200)) improved while urethral dose was reduced, which might potentially result in better treatment outcome. Reduction in rectal dose could potentially reduce rectal toxicity and complications. Reduction in number of needles would minimize edema and thereby could improve postimplant urinary incontinence. This study indicates that the curvilinear implantation approach is dosimetrically superior to conventional rectilinear implantation technique.
Phosphonic Acids. V.<sup>1</sup> An Improved Method for the Preparation of Sodium Diethyl Phosphonate and a Study of its Comparative Reactivity with Alkyl Halides and p-Toluenesulfonates<sup>2</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphonic Acids. V.1 An Improved Method for the Preparation of Sodium Diethyl Phosphonate and a Study of its Comparative Reactivity with Alkyl Halides and p-Toluenesulfonates2Ronald G. Harvey, Terrell C. Myers, Herbert I. Jacobson, and Elwood V. JensenCite this: J. Am. Chem. Soc. 1957, 79, 10, 2612–2615Publication Date (Print):May 1, 1957Publication History Published online1 May 2002Published inissue 1 May 1957https://doi.org/10.1021/ja01567a068Request reuse permissionsArticle Views336Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (490 KB) Get e-Alertsclose Get e-Alerts
Asymptotic and finite-sample properties of estimators based on stochastic gradients (2014)

Stochastic gradient descent procedures have gained popularity for parameter estimation from large data sets. However, their statistical properties are not well understood, in theory. And in practice, avoiding numerical instability requires careful tuning of key parameters. Here, we introduce implicit stochastic gradient descent procedures, which involve parameter updates that are implicitly defined. Intuitively, implicit updates shrink standard stochastic gradient descent updates. The amount of shrinkage depends on the observed Fisher information matrix, which does not need to be explicitly computed; thus, implicit procedures increase stability without increasing the computational burden. Our theoretical analysis provides the first full characterization of the asymptotic behavior of both standard and implicit stochastic gradient descent-based estimators, including finite-sample error bounds. Importantly, analytical expressions for the variances of these stochastic gradient-based estimators reveal their exact loss of efficiency. We also develop new algorithms to compute implicit stochastic gradient descent-based estimators for generalized linear models, Cox proportional hazards, M-estimators, in practice, and perform extensive experiments. Our results suggest that implicit stochastic gradient descent procedures are poised to become a workhorse for approximate inference from large data sets
System definition of the ESA Earth Explorer SPECTRA mission (2003)

The paper describes the system implementation for SPECTRA, which is one of the candidates for the future ESA Earth Explorer Core Missions. The system will enable observations of defined land targets in various spectral bands from the Visible into the Thermal IR and with variable directions of observations. These observations will provide samples of the Bi-directional Reflectance Distribution Function of vegetation. To monitor variations in time of the vegetation properties, the observations will be performed with a revisit of 3 days, assuming cloud-free conditions.
Outline of experimental schemes for measurements of thermophysical and transport properties in warm dense matter at GSI and FAIR (2010)

Different experimental schemes for investigation of warm dense matter produced with intense energetic ion beams are presented. The described target configurations allow direct measurements of thermophysical and transport properties of warm dense matter without hydrodynamic recalculations. The presented experiments will be realized at the current GSI synchrotron SIS-18 and the future FAIR facility in the framework of the WDM-collaboration.
Strong ties vs. Weak ties: Studying the clustering paradox for decentralized search (2009)

We studied decentralized search in information networks and focused on the impact of network clustering on the findability of relevant information sources. We developed a multiagent system to simulate peer-to-peer networks, in which peers worked with one another to forward queries to targets containing relevant information, and evaluated the effectiveness, efficiency, and scalability of the decentralized search. Experiments on a network of 181 peers showed that the RefNet method based on topical similarity cues outperformed random walks and was able to reach relevant peers through short search paths. When the network was extended to a larger community of 5890 peers, however, the advantage of the RefNet model was constrained due to noise of many topically irrelevant connections or weak ties. By applying topical clustering and a clustering exponent
PASSIVATION OF POLYCRYSTALLINE SILICON BY HYDROGEN PLASMA : CHARACTERIZATION BY IMPEDANCE SPECTROSCOPY (2005)

Hydrogenation of silicon materials has attracted a great advantage for its photovoltaic properties. In this paper, we investigated the effects of hydrogen plasma treatment on the structure and properties of silicon surface. The electrical conductivity is measured before and after plasma exposure by impedance spectroscopy on solid indicating a promising method. We observed a strong dependence between measurements and operational conditions (temperature, atmosphere, ...). SIMS, and deuterium effusion are used in order to confirm the impedance measurements. The surface roughness is also evaluated by AFM.
A modulated differential scanning calorimetry and small-angle x-ray scattering study of the interfacial region in structured latices (2001)

The interfacial structure of poly(styrene) (PS)-poly(methyl acrylate) (PMA) structured latices has been investigated by means of modulated-temperature differential scanning calorimetry (M-TDSC) and small-angle x-ray scattering (SAXS). The differential of heat capacity, dCp/dT, signal from M-TDSC was used to quantify the weight fraction of interface in these latices. For PS-PMA (50:50 by weight) structured latices in which the PS component had different crosslink densities (0, 1, 3, 5 and 10 mol% of crosslinking agent), the weight fraction of interface was about 13%. With increasing crosslink density, the fraction of interface increased only slightly. A core-shell model has been used to analyse SAXS data for these PS-PMA latices. M-TDSC can only provide information about the weight fraction of interface, but the combination of M-TDSC and SAXS can provide much more information on the morphology of such structured latices.
Mousses de verre recyclées pour des applications en hyperfréquence (2015)

International audience
Efficacy and Tolerability of Coadministration of Rizatriptan and Acetaminophen vs Rizatriptan or Acetaminophen Alone for Acute Migraine Treatment (2008)

Rizatriptan coadministered with acetaminophen achieved 2 of the 3 primary hypotheses, proving superior to both acetaminophen and placebo for 2-h pain relief, but failing to achieve superiority to rizatriptan alone. RA was as well tolerated as each of the individual agents.
Hydrogen Storage Technology (2013)

The Need for Hydrogen in the 21st Century and Devices for Converting It to Power The Need for Hydrogen-Based Energy Technologies in the 21st Century, Jay Keller, Lennie Klebanoff, Susan Schoenung, and Mary Gillie Hydrogen Conversion Technologies and Automotive Applications, Lennie Klebanoff, Jay Keller, Matt Fronk, and Paul Scott Hydrogen Storage Materials and Technologies Historical Perspectives on Hydrogen, Its Storage, and Its Applications, Bob Bowman, Jr. and Lennie Klebanoff Hydrogen Storage in Pressure Vessels: Liquid, Cryogenic, and Compressed Gas, Guillaume Petitpas and Salvador Aceves Hydrogen Storage in Interstitial Metal Hydrides, Ben Chao and Lennie Klebanoff Development of Onboard Reversible Complex Metal Hydrides for Hydrogen Storage, Vitalie Stavila, Lennie Klebanoff, John Vajo, and Ping Chen Storage Materials Based on Hydrogen Physisorption, Justin Purewal and Channing Ahn Development of Off-Board Reversible Hydrogen Storage Materials, Jason Graetz, David Wolstenholme, Guido Pez, Lennie Klebanoff, Sean McGrady, and Alan Cooper Engineered Hydrogen Storage Systems: Materials, Methods, and Codes and Standards Engineering Properties of Hydrogen Storage Materials, Daniel Dedrick Solid-State H2 Storage System Engineering: Direct H2 Refueling, Terry Johnson and Pierre Benard Engineering Assessments of Condensed-Phase Hydrogen Storage Systems, Bob Bowman, Jr., Don Anton, and Ned Stetson Codes and Standards for Hydrogen Storage in Vehicles, Christine Sloane Index
The reaction of <i>p</i>‐phenylenediarnine with a dichlorotriazin‐<i>s</i>‐yl reactive dye: selective monoacylation (1998)

Selective acylation of a symmetrical diamine with a dichlorotriazinyl reactive dye would enable novel bis‐monochlorotriazinyl dyes to be synthesised, and facilitate the manipulation of dye sunstantivity and hue. We have succeeded in monoacylating p ‐phenylenediamine, in acid solution, with the dichlorotriazinyl dye CI Reactive Red 1 in high yield. No bis‐acylated product was observed by high‐performance liquid chromatography. Further reaction of the monoacylated product, with a different dichlorotriazinyl compound, yielded a novel bis‐monochlorotriazinyl dye.
Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIV-infected patients (2006)

Nodular regenerative hyperplasia appears to be a new cause of portal hypertension in HIV-infected patients. This syndrome can be of critical importance as patients can be exposed to the significant complications of portal hypertension and to refractory ascites which may require liver transplantation.
France's Technologies for Health Program (2008)

The NNTH network has selected and supported dozens of innovative projects in the various fields of healthcare technologies: telematics in healthcare, medical imaging, biomaterials, bioinstrumentation, and techniques for disabled persons. The network has a strong impact on the developments of the field in the scientific community, in industry, and in the medical sector. The basic principle of funding projects promoted by consortia gathering research labs, companies, and clinical centers permitted the emergence of collaborative activities in research and development, applied research, as well as fundamental research. A particular effort is currently necessary in the field of technology evaluation and assessment to improve the quality of care and patient safety.
Postsynthetic deamidation of hemoglobin Providence (beta 82 Lys replaced by Asn, Asp) and its effect on oxygen transport. (1977)

Carriers of hemoglobin Providence have three types of beta chain in their hemolysates. The two abnormal chains have asparagine (Providence N, Prov N) or aspartic acid (Providence D) at position beta 82, instead of lysine. In vitro, only two beta chains are synthesized by reticulocytes of carriers, betaA and betaProv N. In vivo studies showed that the specific activity of Providence N was initially 10-fold higher than that of Providence D; the specific activities of the two labeled hemoglobins were approximately equal 5 wk after injection of isotope. Oxygen affinity of carriers' blood was somewhat increased, but they were not polycythemic. The affinity of the purified hemoglobins Providence was decreased. Addition of 2, 3 diphosphoglycerate had little effect on the affinity of either hemoglobin component, and addition of inositol hexaphosphate produced no change in the affinity of Providence D. These studies demonstrate that Providence N is deamidated to Providence D during the life span of the erythrocyte, and suggest this finding may represent only an easily observed prototype of posttranslational modification of proteins in general. Despite and abnormal P50 of the blood, oxygen transport is probably normal in carriers of the abnormal hemoglobins.