gebhart/patrepeval huggingface dataset:
Detection of Human Papillomavirus Type 16 in Bowenoid Papulosis and Invasive Carcinoma Occurring in the Same Patient With a History of Cervical Carcinoma (1988)

To the Editor.— Human papillomavirus (HPV) type 16 (HPV-16) has been found in lesions of bowenoid papulosis, Bowen's disease, and cervical intraepithelial neoplasia, as well as anogenital carcinoma. Although bowenoid papulosis is well known to occur in patients who had been treated for cervical carcinoma, 1 the progression of bowenoid papules themselves to invasive carcinoma is not well documented. In the present report we describe a woman with a previous history of treated carcinoma of the cervix who developed invasive carcinoma of Bowen's type, apparently arising from bowenoid papulosis on her perianal region, and regional lymph node metastasis; in both lesions of the invasive carcinoma and of bowenoid papulosis we found the presence of HPV-16 DNA. This case presents strong evidence for a causal relationship between HPV-16 and cancer derived from its precursor lesion. Report of a Case.— A 56-year-old woman was first seen by us in May 1986, with a complaint of a nodule of ten months' duration on the left side of her perianal
Sir Edmund Orme (2008)

<sc>The Statement</sc>* appears to have been written, though the fragment is undated, long after the death of his wife, whom I take to have been one of the persons referred to. There is however nothing in the strange story to establish this point,...
Sirolimus PK trial: A pharmacokinetic study of the sirolimus‐eluting Bx Velocity stent in patients with de novo coronary lesions (2005)

This study was conducted to assess the systemic drug release and distribution of sirolimus-eluting stents. Early results with sirolimus-eluting stents have demonstrated a favorable outcome for reducing restenosis post coronary intervention. However, the clinical systemic pharmacokinetics of sirolimus released from these stents has not been investigated. Sirolimus-eluting stents (150-178 mcg/18 mm stent) were implanted in 19 patients with coronary artery disease using standard techniques. Blood samples were obtained at multiple times to determine the kinetics of sirolimus release and elimination. Non-compartmental analysis showed that the maximum blood concentration of sirolimus occurred between 3 and 4 hr after implantation, with a peak concentration of 0.57 +/- 0.12 ng/mL (mean +/- SD) and 1.05 +/- 0.39 ng/mL in patients receiving one or two stents, respectively. Terminal-phase elimination half-life was independent of the number of stents and averaged at 213 hr, a value longer than that seen in patients following oral dosing. The apparent clearance was 1.46 +/- 0.45 L/hr with an apparent volume of distribution in the terminal phase of 407 +/- 111 L (data for both stent doses pooled). Minimal measurable blood levels were detectable at 7 days. Peak whole blood level following sirolimus stent implantation in humans is proportional to the number of stents implanted. The prolonged terminal half-life may reflect kinetics of blood clearance combined with continued drug elution and secondary local tissue release.
Homologous Silver Bismuth Chalcogenide Halides <sup>(N, x)</sup>P. III. The <sup>(4, x)</sup>P, <sup>(5, x)</sup>P, and <sup>(7, x)</sup>P Structure Families of Modular Compounds with Tunable Composition and Structure (2008)

Abstract The crystal structures of six members of the homologous series with general formula [Bi QX ] 2 [Ag x Bi 1−x Q 2−2x X 2x−1 ] N+1 ( Q = S, Se; X = Cl, Br; 1/2 ≤ x ≤ 1) and N = 4, 5, or 7 were determined by single‐crystal X‐ray diffraction. The series are characterized by the parameters N and x and are denoted (N, x) P. Ag 3 Bi 4 S 6 Cl 3 ( x = 0.60) (I) , Ag 3.5 Bi 3.5 S 5 Br 4 ( x = 0.70) (II) and Ag 3.65 Bi 3.35 Se 4.70 Br 4.30 ( x = 0.73) (III) belong to (4, x )P series Ag 5x Bi 7−5x Q 12−10x X 10x−3 and adopt the AgBi 6 S 9 structure type. The (5, x) P compound Ag 3.66 Bi 4.34 S 6.68 Br 3.32 (IV) , which corresponds to x = 0.61 in Ag 6x Bi 8−6x S 14−12x Br 12x−4 , crystallizes isostructurally to AgBi 3 S 5 . The compounds Ag 4.56 Bi 5.44 Se 8.88 Br 3.12 ( x = 0.57) (V) and Ag 5.14 Bi 4.86 S 7.76 Br 4.24 ( x = 0.64) (VI) , which are members of (7, x) P series Ag 8x Bi 10−8x Q 18−16x Br 16x−6 , adopt the Ag 3 Bi 7 S 12 structure type. In the monoclinic crystal structures (space group C 2/ m ) two kinds of layered modules alternate along [001]. Modules of type A uniformly consist of paired rods of face‐sharing monocapped trigonal prisms around Bi atoms with octahedra around mixed occupied metal positions ( M = Ag/Bi) between them. Modules of type B are composed of [ MZ 6 ] octahedra, which are arranged in NaCl‐type fragments of thickness N . All structures exhibit Ag/Bi disorder in octahedrally coordinated metal positions as well as Q / X mixed occupation of some anion positions. Corresponding to their black color, all compounds are narrow‐gap semiconductors ( E g = 0.35 eV for (II) ). General characteristics of the entire class of (N, x) P compounds are gathered in a catalogue.
The Myopia of Imperfect Climate Models: The Case of UKCP09 (2013)

The United Kingdom Climate Impacts Program’s UKCP09 project makes high-resolution forecasts of climate during the twenty-first century using state of the art global climate models. The aim of this article is to introduce and analyze the methodology used and then urge some caution. Given the acknowledged systematic errors in all current climate models, treating model outputs as decision-relevant probabilistic forecasts can be seriously misleading. This casts doubt on our ability, today, to make trustworthy, high-resolution predictions out to the end of this century.
Studies on the Cellular Basis of Radiation Lethality (1968)

SummaryA model is presented which defines the parameters of the curve for neoblast (stem cell) survival of reproductive integrity in terms of the parameters of the planarian radiation mortality curve. Two constants of the model, namely, the initial number of neoblasts (N) and the repopulation probability (α) for the independent repopulation of the irradiated planarian tissues by surviving neoblasts are defined and, for the species Dugesia lugubris, measured. The assumption that the repopulation probability for each neoblast is independent of the number of neoblasts is confirmed experimentally for diploid and triploid neoblasts of exogenous and endogenous origin. The repopulation probability for diploid (endogenous and exogenous) and triploid (endogenous only) neoblasts are not significantly different. Triploid exogenous neoblasts, however, are only 16 per cent as effective as endogenous triploid or exogenous diploid neoblasts. Values of D0 and NαE (E = extrapolation number) are given for diploid, triploid and tetraploid neoblasts of D. lugubris, and for four other species.
Efficient Large-Scale Multi-Modal Classification (2018)

While the incipient internet was largely text-based, the modern digital world is becoming increasingly multi-modal. Here, we examine multi-modal classification where one modality is discrete, e.g. text, and the other is continuous, e.g. visual representations transferred from a convolutional neural network. In particular, we focus on scenarios where we have to be able to classify large quantities of data quickly. We investigate various methods for performing multi-modal fusion and analyze their trade-offs in terms of classification accuracy and computational efficiency. Our findings indicate that the inclusion of continuous information improves performance over text-only on a range of multi-modal classification tasks, even with simple fusion methods. In addition, we experiment with discretizing the continuous features in order to speed up and simplify the fusion process even further. Our results show that fusion with discretized features outperforms text-only classification, at a fraction of the computational cost of full multi-modal fusion, with the additional benefit of improved interpretability.
Intracellular pH Regulation in Bovine Aortic Endothelial Cells: Evidence of Both Na<sup>+</sup>/H<sup>+</sup> Exchange and Na<sup>+</sup>-Dependent Cl<sup>–</sup>/HCO<sup>–</sup><sub>3</sub> Exchange (1998)

Regulation of intracellular pH (pHi) was studied in cultured bovine aortic endothelial cells, an important cell system for cardiovascular research. Suspended cells were acidified by the NH4Cl prepulse technique as well as by exposure to CO2/HCO3-. Subsequent rates of pHi recovery were monitored using the fluorescent dye 2',7'-bis(2-carboxyethyl)-5-(6)-carboxyfluorescein (BCECF). In HCO3(-)-free solutions, an EIPA-sensitive, Na+-dependent mechanism fully accounted for realkalinization, namely the Na+/H+ exchanger (NHE). In the presence of HCO3-, an additional acid efflux mechanism was found. This one was dependent on Na+ and intracellular Cl-, EIPA-insensitive but DIDS-sensitive, and therefore represented a Na+-dependent Cl-/HCO3- exchanger (NCBE). In summary, two acid-extruding mechanisms were identified in bovine aortic endothelial cells: NHE and NCBE.
Single plasmon generation in an InAs/GaAs quantum dot in a transfer-printed plasmonic microring resonator (2019)

We report single plasmon generation with a self-assembled InAs/GaAs quantum dot embedded in a plasmonic microring resonator. The plasmonic cavity based on a GaAs microring is defined on an atomically-smooth silver surface. We fabricated this structure with the help of transfer printing, which enables the pick-and-place assembly of the complicated, heterogeneous three dimensional stack. We show that a high-order surface-plasmon-polariton transverse mode mediates efficient coupling between the InAs/GaAs quantum dots and the plasmonic cavity, paving the way for developing plasmonic quantum light sources based on the state-of-the-art solid-state quantum emitters. Experimentally, we observed Purcell-enhanced radiation from the quantum dot coupled to the plasmonic mode. We also observed a strong anti-bunching in the intensity correlation histogram measured for scattered photons from the plasmonic resonator, indicating single plasmon generation in the resonator. Our results will be important in the development of quantum plasmonic circuits integrating high-performance single plasmon generators.
Prime-mover response and system dynamic performance (1966)

Prime-mover response characteristics are influenced by the dynamics of turbines, boilers, and hydraulic systems, as well as by such control devices as speed governors and boiler-turbine controls. Some of the common types of prime-mover systems considered are the conventional single and double reheat systems, once-through units, and hydraulic turbine units. The pertinent phenomena are discussed, as are the implications of prime-mover response in the light of normal and emergency load-change duty.
Synthesis of optically active 1,3,2-oxazaphospholidine 2-sulfides and 1,3,2-benzodioxaphosphorin 2-sulfides. (1987)

The optical isomers often kinds of insecticidal 1, 3, 2-oxazaphospholidine 2-sulfides (OS) and two kinds of 1, 3, 2-benzodioxaphosphorin 2-sulfides (BS), including the commercial insecticide salithion, were synthesized in high optical purity by using two optically active aryl methyl phosphorochloridothionates (AMPC) as chiral two-step phosphorylating reagents. Their configurations were assigned according to the reaction mechanisms and supported by proton NMR information.
Dynamic Recrystallization Behaviour of Twin Roll Cast AZ31 Strips during Hot Deformation (2014)

The recrystallization behaviour of a Twin Roll Cast AZ31 alloy, under deformation conditions corresponding to the initial stands of a magnesium hot rolling process, has been investigated. A set of strain levels, beginning at the critical strain for the onset of dynamic recrystallization has been studied. The dynamic recrystallization, taking place during hot deformation of magnesium alloy AZ31 is analyzed with help of plane strain compression tests conducted together with microscopic examination. Dynamically recrystallized volume fraction and size of dynamically recrystallized grains increase with increasing strain. When the strain is constant, the dynamically recrystallized volume fraction is higher at higher deformation temperatures or lower strain rates. Furthermore, it has been found out that deformation temperature plays a major role, rather than strain rates, in activating the dynamic recrystallization process during deformation. The results were used to identify the coefficients for the JMAK-model approach on the dynamic recrystallization of an AZ31 TRC-sheet.
Use of Micromethod for Phenylalanine in Management of Phenylketonuric Patients (1962)

Abstract A micromethod for measurement of blood phenylalanine is described. The procedure is advantageous in management of phenylketonuric children under treatment.
Microwave Imaging Using a Planar Scanning System with Step-Frequency Synthesized Pulse (2006)

Initial experimental study into the use of a planar microwave imaging system with step-frequency synthesized pulse for possible use in medical applications is described. Simple phantoms, consisting of a plastic container and objects with high dielectric constant or conductivity emulating tumours, are scanned with a probe antenna over a planar surface in the X-band frequency range. Successful detection of these objects is demonstrated.
Effect of 3-thiadicarboxylic acid on lipid metabolism in experimental nephrosis. (1993)

The effect of the sulfur-substituted fatty acid analogue 1,10 bis(carboxymethylthio)decane, also known as 3-thiadicarboxylic acid, on puromycin aminonucleoside-induced nephrotic hyperlipidemia was studied in rats. Treatment with 3-thiadicarboxylic acid (250 mg/kg) for 5 days reduced plasma levels of triglycerides from 5.8 to 2.7 mmol/L and cholesterol from 11.0 to 7.7 mmol/L. This was accounted for by decreases in very-low-density lipoprotein triglycerides, very-low-density lipoprotein cholesterol, and low-density lipoprotein cholesterol, without any major changes in the composition of plasma lipoproteins. The activities of two enzymes involved in fatty acid synthesis (ATP:citrate lyase and fatty acid synthetase) were inhibited by 3-thiadicarboxylic acid treatment, whereas acetyl-coenzyme A carboxylase activity was unchanged. In contrast, treatment with the sulfur-substituted fatty acid analogue induced the peroxisomal beta-oxidation of fatty acids ninefold and the mitochondrial beta-oxidation by 54% to 73%, depending on the substrate used. This was accompanied by a 26% reduction in hepatic triglyceride secretion rate. The hepatic phosphatidate phosphohydrolase activity was unchanged. 3-Thiadicarboxylic acid treatment suppressed the activity of the rate-limiting enzyme in cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, by 58%, whereas hepatic LDL receptor expression was unaltered. The activities of lipoprotein lipase and hepatic lipase were unchanged by treatment. These results demonstrated that treatment with 3-thiadicarboxylic acid ameliorates hyperlipidemia in experimental nephrosis primarily by decreasing the overproduction of very-low-density lipoprotein present. The data also indicate that hepatic very-low-density lipoprotein synthesis and secretion is strongly influenced by the availability of the fatty acid substrate under the same hyperlipidemic conditions.
A Variety of Staphylococcal Plasmids Present as Multiple Copies (1973)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Biopharmaceutical characteristics of a new propranolol/ hydrochlorothiazide tablet combination (1982)

Experiments have been carried out in dogs and man to determine the effect of hydrochlorothiazide (HCT) on the pharmacokinetics of propranolol and to evaluate the bioavailability of two dosage forms containing both propranolol and HCT (40/25 and 80/25 mg, respectively). In adult male beagles, 50 mg of HCT had no apparent effect on AUC, Cmax, Tmax, and T1/2 of propranolol administered concurrently. In man, INDERIDE (40/25 mg) and INDERIDE (80/25 mg) were shown to be similar in bioavailability to the reference formulations, i.e. the same amount of drugs administered as the separate tablets of INDERAL plus HYDRODIURIL.
Immunosuppressive effects of the macrolide antibiotic bafilomycin towards lymphocytes and lymphoid cell lines. (1988)

The effects of bafilomycin macrolide antibiotics on primary lymphocytes and on tumor cell lines were investigated. Bafilomycin A markedly suppressed DNA, RNA, and protein synthesis in splenocyte cultures of several inbred mouse strains. Bafilomycins were also inhibitory towards cultures of concanavalin A- or lipopolysaccharide-activated murine spleen cells, and inhibited the mitogen-induced differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. Corresponding results were obtained in human cell cultures. A hydrolysis product of the bafilomycin molecule was inactive. Bafilomycin also inhibited the growth of various lymphoid cell lines, the B cell line BCL1, the macrophage cell lines J774 and P338D1, and the T cell line EL4. The sensitivity of the tumor cell lines increased when, simultaneously with bafilomycin, mitogens were applied to the cell cultures. The immunosuppressive action of cyclosporin A could be enhanced by bafilomycin, which could be of importance for the elucidation of the molecular mechanism of T cell suppression, and for applied medical research.
Ovarian autoimmunity and corticotherapy in an in-vitro fertilization attempt (1995)

This case report describes a successful pregnancy and delivery in a woman presenting with ovarian autoimmunity who had previously been involved in two unsuccessful in-vitro fertilization (IVF) attempts. Ten days before a third attempt, she began a regimen of 25 mg per day of prednisolone which was continued throughout the whole IVF protocol. Ovulation was induced by human menopausal gonadotrophin. After administration of 5000 IU of human chorionic gonadotrophin, 18 oocytes were collected. At 48 h after insemination with the patient's husband's spermatozoa, four 4-cell pre-embryos were transferred. A singleton pregnancy developed and led to the birth of a girl who is doing well 10 months later.
Fundamental Limits to Single-Photon Detection Determined by Quantum Coherence and Backaction (2017)

Single-photon detectors have achieved impressive performance, and have led to a number of new scientific discoveries and technological applications. Existing models of photodetectors are semiclassical in that the field-matter interaction is treated perturbatively and time-separated from physical processes in the absorbing matter. An open question is whether a fully quantum detector, whereby the optical field, the optical absorption, and the amplification are considered as one quantum system, could have improved performance. Here we develop a theoretical model of such photodetectors and employ simulations to reveal the critical role played by quantum coherence and amplification backaction in dictating the performance. We show that coherence and backaction lead to tradeoffs between detector metrics, and also determine optimal system designs through control of the quantum-classical interface. Importantly, we establish the design parameters that result in a perfect photodetector with 100% efficiency, no dark counts, and minimal jitter, thus paving the route for next generation detectors.
An Empirical Analysis of Urban Form, Transport, and Global Warming (2008)

Does urban form affect travel choices and thus C02 emissions by individuals? If this is the case, then urban form and policies that influence it deserve serious attention in the context of long-term climate policy. To address this issue, we examine the impact of urban density on commuting behavior, and the consequences for C02 emissions. The empirical investigation is based on an instrumental variable approach (IV), so as to take account of endogeneity of residence location. We decompose travel demand into components related to modal split and commuting distance by each mode.
ChemInform Abstract: Wittig Rearrangement of Allyl and Propargyl Furfuryl Ethers Leading to 2‐Furylmethanol Derivatives. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Performance analysis of image registration techniques (1989)

Discussed various important topics in image registration. Special emphasis has been placed on local methods and the issue of computational efficiency. The time factor is crucial, not only in many real-time applications, but also in all applications in which interactive registration is more appropriate and effective. There are a number of questions concerning optimal registration which remain to be solved. The techniques presented in this paper have to be augmented with an application-dependent, high-level, symbolic feature matching. The authors believe that these two approaches i.e. numerical registration and symbolic matching, are complimentary. In an interactive mode how the images to be registered are presented, manipulated and superimposed, has a crucial importance for identification and precise location of control points, and consequently may determine the quality of registration. >
Diagnosis of Perinatal Human Immunodeficiency Virus Infection by Polymerase Chain Reaction and p24 Antigen Detection after Immune Complex Dissociation in an Urban Community Hospital (1997)

Results of polymerase chain reaction (PCR) and p24 antigen detection after immune complex dissociation (p24-ICD) were compared with antibody results after 18 months of age for human immunodeficiency virus (HIV) diagnosis in 345 prospectively followed, perinatally exposed infants. Of 59 infected and 286 uninfected infants tested at 1-6 months of age, sensitivity and specificity were, respectively, 100% and > 97% for PCR and 90% and > 97% for p24-ICD. Testing was done on > or = 2 occasions in the first 6 months of life in 43 infected infants; 77% had > or = 2 positive results with the same test. Of these infants, 68% had 2 positive p24-ICD tests. In uninfected infants, 96% had only negative tests; none had > 1 positive. By 6 months, all uninfected infants with > or = 2 PCR results could have been diagnosed. HIV status can be determined by PCR by age 6 months in most HIV-exposed infants. p24-ICD should not be used alone, because of its lower sensitivity, but may be useful in areas without advanced laboratory support.
Molecules Involved in Self‐Incompatibility in Flowering Plants (1997)

This chapter contains sections titled: Introduction Genetic Control of Self-Incompatibility Sporophytic Self-Incompatibility in the Brassicaceae Gametophytic Self-Incompatibility in the Solanaceae Gametophytic Self-Incompatibility in Other Families Concluding Remarks Literature Cited
Subspace-based delay estimation for CDMA communication systems (2002)

We consider a subspace-based approach to delay estimation for code division multiple access communication systems. By exploiting the eigenstructure of the received signal's sample correlation matrix, the observation space is partitioned into a signal subspace and a noise subspace without prior knowledge of the users' delays. The delay estimate is formed by maximizing the likelihood of the projection of a given user's spreading waveform into the estimated noise subspace, thus decomposing the multiuser delay estimation problem into a series of single user problems. This subspace-based approach requires no preamble for acquisition, is near-far resistant, and is robust to changing channel conditions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>