gebhart/patrepeval huggingface dataset:
APC-Resistenz: Klinik, Pathophysiologie und Diagnostik (1996)

Zusammenfassung Die APC-Resistenz ist derzeit der häufigste hereditäre Defekt, der mit einem hohen Risiko für Thromboembolien assoziiert ist. Bei diesem Defekt handelt es sich in 97% der Fälle um eine Mutation im Faktor-V-Gen (nt 1.691 G→A), wodurch im Protein der Faktor V Arg 506 durch Gln ersetzt ist. Diese Variante wird auch als Faktor V Leiden bezeichnet. Der heterozygote Defekt ist mit einem 5- bis 10mal, der homozygote Defekt mit einem 50- bis 100mal höheren Thromboserisiko verbunden. Aufgrund seiner hohen Prävalenz (Normalbevölkerung ca. 5%) sollte die Bestimmung des Faktor V Leiden an erster Stelle der Parameter zur Diagnostik einer hereditären Thrombophilie stehen. Als Suchtest für die Faktor-V-Mutation hat sich die Bestimmung der APTT in An- und Abwesenheit von aktiviertem Protein C nach vorheriger Mischung der Probe mit einem Faktor-V-Mangelplasma bewährt. Der Test kann auch im Plasma von Patienten unter oraler Antikoagulation durchgeführt werden. Der störende Einfluß von Heparin wird nicht völlig eliminiert. Bis zu einer Verlängerung der APTT auf 60–70 sec (ohne Mischung mit Faktor-V-Mangelplasma) führt der Test zu zuverlässigen Ergebnissen. Liegt die APTT ohne APC mehr als 50% oberhalb des Normbereichs, kann ein Faktor-V-Leiden-Defekt verdeckt werden, da die APTT in Anwesenheit von APC ebenfalls verlängert ist. Mögliche Ursachen hierfür sind Faktor-V-Mangel der Probe oder Vorliegen von Lupus-Antikoagulans. Umgekehrt kann eine APC-Resistenz durch Plättchen in der Probe, insbesondere nach Einfrieren, vorgetäuscht werden. Dieser Artefakt kann durch zweifache Zentrifugation der Probe vor dem Einfrieren vermieden werden. Die Auswertung der erhaltenen Gerinnungszeiten erfolgt entweder über die Ratio der APTT mit und ohne APC-Zusatz oder idealer-weise unter Bezug auf einen Referenzplasmapool als normierte APC-Ratio oder in % APC-Sensitivität. Letztere läßt sich unter Verwendung von Kalibratoren mittels einer Referenzkurve ermitteln. Besonders bei jüngeren Patienten mit APC-Resistenz sollte die Absicherung der Diagnose durch den Nachweis der Faktor-V-Mutation erfolgen. Auch bei grenzwertigen Befunden für die APC-Resistenz und zur Unterscheidung zwischen heterozygoten und homozygoten Defektträgern ist die Mutationsanalyse unumgänglich.
Caro's Acid Supported on Silica Gel. Part 3<sup>1</sup>: A Mild and Selective Reagent for Regeneration of Carbonyl Compounds from Oximes (2000)

Abstract Various oximes were converted into the corresponding carbonyl compounds in high yields with Caro's acid supported on silica gel in acetic acid at room temperature.
The fate of certain organic acids and amides in the rabbit. 10. The application of paper chromatography to metabolic studies of hydroxybenzoic acids and amides (1950)

1. Sulphapyridine containing 35S has been syn- thesized.
Insulin-like growth factors in obstetrics (2000)

Data from a number of studies reported during the past two decades indicate that the insulin-like growth factor (IGF) system, including IGF-I and IGF-II, their receptors and six high-affinity binding proteins, is involved in the control of foetal and placental growth and development. Recent studies that addressed the role of the IGF system in pregnancy and the clinical usefulness of IGF and IGF-binding protein measurements in obstetrics are reviewed and discussed.
Inhibitory effect on immunoglobulin E production <i>in vivo</i> and <i>in vitro</i> by <i>Siegesbeckia glabrescens</i> (2001)

Elevated levels of immunoglobulin (Ig)E are associated with immediate-type allergic reactions. The effect of an aqueous extract of Siegesbeckia glabrescens (Compositae) whole plants (SGWP) on in vivo and in vitro IgE production was studied in mice. SGWP dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and Bordetella pertussis toxin absorbed to aluminium hydroxide gel. SGWP dose-dependently inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti-allergic activity by inhibiting IgE production from B cells.
A Framework for Over the Air Provider-Initiated Software Deployment on Mobile Devices (2008)

While mobile users want to obtain software anywhere and anytime without the knowledge of software availability in advance, software providers want to deploy their software to mobile devices without the users' intervention. However, because mobile devices expose special characteristics such as restriction of capability, heterogeneity, mobility, wireless connectivity, and context-orientation, deployment of software or context-aware services on mobile devices is a problematical issue. This work proposes a framework for over the air provider-initiated software deployment on mobile devices (OTA-PSD). Using the OTA-PSD, once new software or software updates are available, by the initiation of the provider, the compatible mobile devices, which have subscribed to the provider, will automatically receive this software with the minimum users' intervention. This framework allows providers to deploy their services on mobile devices based on users' context and device specification. To demonstrate the feasibility of the OTA-PSD, we developed a deployment system based on the OTA-PSD. We successfully demonstrated the deployment of a case study using our deployment system.
Development of a Novel Gait Rehabilitation Device with Hip Interaction and a Single DOF Mechanism (2019)

In this paper, a novel, low-cost lower extremity gait rehabilitation device using a single actuator is presented. The proposed device is based on a single DOF 8-bar Jansen mechanism, which was recently introduced as an efficient walking mechanism for legged robots. The mechanism is synthesized to generate the ankle trajectory during human gait relative to the hip, in terms of both position and time. Two mechanisms, one for each lower limb, are applied reciprocally and mechanically synchronized to guarantee symmetric gait. A custom designed seat-type weight support system is also introduced. It supports weight of the user and mechanisms, and also provides the required interaction while maintaining mobility at the hip. To accommodate different users, several parameters of the mechanism are adjustable. Ease of donning-doffing action, weight-bearing and possibility of unhindered arm swing have been considered to provide an effective and user-friendly training environment. A prototype is manufactured, and a pilot study with a healthy subject is conducted to demonstrate feasibility of the concept. Due to ease of control, cost-effectiveness and high intrinsic safety, the proposed system potentially offers a possible method of gait training.
Rate of reaction of hydrogen sulfide-carbonyl sulfide mixtures with fully calcined dolomite (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleRate of reaction of hydrogen sulfide-carbonyl sulfide mixtures with fully calcined dolomiteVivek S. Kamath and Thomas W. PetrieCite this: Environ. Sci. Technol. 1981, 15, 8, 966–968Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/es00090a014https://doi.org/10.1021/es00090a014research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Popular Ensemble Methods: An Empirical Study (1999)

An ensemble consists of a set of individually trained classifiers (such as neural networks or decision trees) whose predictions are combined when classifying novel instances. Previous research has shown that an ensemble is often more accurate than any of the single classifiers in the ensemble. Bagging (Breiman, 1996c) and Boosting (Freund & Shapire, 1996; Shapire, 1990) are two relatively new but popular methods for producing ensembles. In this paper we evaluate these methods on 23 data sets using both neural networks and decision trees as our classification algorithm. Our results clearly indicate a number of conclusions. First, while Bagging is almost always more accurate than a single classifier, it is sometimes much less accurate than Boosting. On the other hand, Boosting can create ensembles that are less accurate than a single classifier -- especially when using neural networks. Analysis indicates that the performance of the Boosting methods is dependent on the characteristics of the data set being examined. In fact, further results show that Boosting ensembles may overfit noisy data sets, thus decreasing its performance. Finally, consistent with previous studies, our work suggests that most of the gain in an ensemble's performance comes in the first few classifiers combined; however, relatively large gains can be seen up to 25 classifiers when Boosting decision trees.
Object-oriented network protocol implementation-Signaling System 7 (2002)

Object-oriented implementation of Signaling System 7 (OOSS7) sets an example of applying object-oriented methods onto network protocol implementations. Unlike many of the implementations where SS7 was integrated into systems in an exclusive and device-dependent way, OOSS7 inherits the advantages of object-oriented programming: reusability, safety and device independence. In this paper, the object-oriented analysis of SS7 is given based on SDL (specification and description language) and MSC (message sequence chart). The data structure and scheduling algorithm are discussed. The compatibility of TUP (telephone user part) and ISUP (ISDN user part) is proved. The experimental system passed the validation test both in the laboratory and in the central office with real operating traffic.
COMPATIBILITY OF INSECTICIDES WITH ENTOMOPATHOGENIC FUNGI <em>Beauveria bassiana</em> AND <em>Metarhizium anisopliae</em> (2017)

Insecticide use has produced negative impact by affecting the non-target predatory organisms in nature, one of which is the entomopathogenic fungi, Beauveria bassiana and Metarhizium anisopliae. Interactions occur, however, between insecticides and the entomopathogens. The combination of insecticides at a low dose and an entomopathogenic fungus can work synergistically to increase pest insect mortality. This combination is particularly advantageous because it decreases the insecticide dose applied, reduces environmental contamination, and decreases pest resistance. The study purpose was to determine the compatible working insecticide dose and the entomopathogenic fungi B. basiana and M. anisopliae. The experimental design applied completely randomized design consisting of 15 treatments and four replicates. There were five types of insecticides with three different doses each (0.5 × Dose of Field (DF), 1 × DF, and 2 × DF), whereas the fungal isolates included B. basiana and M. anisopliae. The parameters observed were the germination percentage of conidia, the percentage of inhibition, and the number of conidia.ml-1. Data were analyzed using ANOVA (5% error rate). The mean values were analyzed by DMRT p < 0.05. Deltamethrin 0.5 x DF, and imidacloprid 0.5 x DF demonstrated the highest conidial germination in B. basiana and M. anisopli, respectively. Insecticides showing the highest vegetative growth on B. basiana and M. anisopliae at 7 DAI was imidacloprid 0.5 x DF, while at 14 DAI was imidacloprid 0.5 x DF and chlorphyrifos 2 x DF, respectively. The highest conidial production of the fungi was triggered by imidacloprid 0.5 x DF. Based on compatibility calculation, imidacloprid 0,5 x DF worked with B. basiana (BI: 67.77) and M. anisopliae (BI: 67.16).
Apoptosis Induced by Transforming Growth Factor-β in Fetal Hepatocyte Primary Cultures (1996)

Transforming growth factor-beta (TGF-beta), a growth regulator of fetal hepatocytes in primary culture, also regulates death of these cells. Dose-response analysis showed that the TGF-beta concentration needed to induce hepatocyte death (2.5 ng/ml) was 5 times that needed to inhibit growth in these cells (0.5 ng/ml). In response to TGF-beta, hepatocytes induced DNA fragmentation and the appearance of nuclei with a DNA content lower than 2C (diploid content), typical of a programmed cell death model. TGF-beta-induced apoptosis in fetal hepatocytes was preceded by an induction of reactive oxygen species production and a decrease in the glutathione intracellular content, indicating that this factor induces oxidative stress in fetal hepatocytes. Studies performed to analyze levels of c-fos mRNA, a gene whose expression is modulated by redox state, demonstrated that only high, apoptotic concentrations of TGF-beta (2.5 ng/ml) produced an increase in the mRNA levels of this gene, the level of induction being similar to that found when cells were incubated in the presence of tert-butyl hydroperoxide. Gel mobility shift assays showed that the c-fos-induced expression was coincident with an increase in AP-1 activity. Finally, cell death induced by TGF-beta in fetal hepatocytes was partially blocked by radical scavengers, which decreased the percentage of apoptotic cells, whereas these agents did not modify the growth-inhibitory effect elicited by TGF-beta in these cells. In summary, the results presented in this paper provide evidence for the involvement of an oxidative process in the apoptosis elicited by TGF-beta in fetal hepatocytes.
The interaction of a single laser-generated cavity in water with a solid surface (1996)

This paper reexamines the collapse of a cavity in water and its role in possible damage processes. Laser-generated cavities were formed near to a water–solid boundary and simultaneous observations made of the collapse processes and stresses on the solid surface. Using schlieren photography and a thin film transducer on the solid, the importance of fluid flow to induced material stress was determined. The stresses in the solid were also observed using dynamic photoelasticity. The cavity deformation in the collapse phase was observed with high spatial and temporal resolution. Two distinct surface stresses were observed associated with bubble collapse near the boundary. The results indicate that one was due to a shock wave. It is postulated that the second stress was associated with fluid flow through the bubble, set up by the so-called ‘‘liquid jet’’ as opposed to jet impact on its own.
Liquid/Liquid Optical Waveguides Using Sheath Flow as a New Tool for Liquid/Liquid Interfacial Measurements (2003)

A liquid/liquid optical waveguide was constructed using a sheath flow. Since the refractive index of an organic solvent is generally higher than that of water (nD = 1.33), light introduced into the inner organic flow should proceed with total multi-reflection within the inner flow, so that the inner part of the sheath flow acts as the core of an optical waveguide. This sheath flow liquid/liquid optical waveguide was stable and showed no substantial background scattering. Moreover, it is applicable to both miscible and immiscible liquid/ liquid interfaces. Thus, it may become a new tool for studying liquid/liquid interfaces as well as for sensitive optical measurements.
Oxytocin receptors in human adenocarcinomas of the endometrium: presence and biological significance (2000)

Oxytocin receptors (OTRs) are expressed in endometrial cells and oxytocin (OT) participates in endometrial functions. In cancers derived from other OT target tissues, such as breast and neural tissues, the expression of OTRs and the antiproliferative effect of OT on cancer cells has been previously observed. This study was therefore designed to search for OTR expression and the OT effect in endometrial carcinomas. To demonstrate the presence and the location of OTRs and OTR mRNA immunocytochemical, reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ hybridization (ISH) procedures were employed in a series of human adenocarcinomas of the endometrium. Using an anti-OTR monoclonal antibody (IF3), OTRs were demonstrated in the large majority of endometrial carcinomas (82%), with a pattern of positivity varying from diffuse to focal, according to tumour differentiation. The OTR gene was demonstrated in 78% of the cases by RT-PCR and its presence was confirmed in selected cases by ISH. Moreover, in a human endometrial carcinoma cell line (COLO 684) OTR was demonstrated by immunofluorescence and RT-PCR and it was observed that OT treatment (10(-11)-10(-7) M) significantly inhibited cell proliferation. Neither toxic effects nor apoptosis were induced by OT treatment. The addition of an inhibitor of protein kinase A (PKA) to the culture medium abolished the antiproliferative effect of OT, suggesting that cAMP via PKA could be the intracellular mediator of the OT effect, as previously observed in breast and neural tumours. In conclusion, this study presents evidence of OTR expression in human endometrial carcinomas and of an OT antiproliferative effect on human endometrial cancer cells in vitro. It is further suggested that OT and OTR may be involved in the regulation of endometrial cells, not only in physiological conditions but also in a neoplastic context.
APPROXIMATIONS TO THE REFLECTION AND TRANSMISSION COEFFICIENTS OF PLANE LONGITUDINAL AND TRANSVERSE WAVES* (1961)

A bstract The reflection and transmission coefficients for vertical incidence can be very closely approximated by computing the direct‐reflected and the direct‐transmitted portion for transition layers, and letting the thickness approach zero. The same procedure can then be applied to the general case of oblique incidence, which yields approximate values of the respective coefficients, including those of the converted waves. The approximate values compare well with the exact values calculated by Muskat and Meres (1940). These approximations might be adequate for all cases occurring in reflection seismic prospecting. They can also be used, possibly even more profitably, for the derivation of some rules governing the reflection process. The influence of Poisson's ratio can be read more or less directly from the approximate formulas. All converted waves depend primarily on the ratio of the shear velocities.
Functional Dissection of the Pro-apoptotic Protein Bik (1997)

Bik is a potent pro-apoptotic protein, which complexes with various anti-apoptotic proteins such as Bcl-2, Bcl-xL, 19-kDa adenovirus E1B, and EBV-BHRF1. The mechanism by which Bik promotes cell death is not known. It shares a conserved domain, BH3, with other pro-apoptotic proteins, Bax, Bak, Bid, and Hrk, and certain anti-apoptosis proteins such as Bcl-2 and Bcl-xL. Mutations within the BH3 domain of Bik abrogate its ability to induce cell death and to complex with anti-apoptosis proteins. This result is consistent with the hypothesis that Bik may promote cell death by complexing with and antagonizing the activity of endogenous cellular anti-apoptosis proteins such as Bcl-2 and Bcl-xL. To elucidate the relationship between protein complex formation and induction of cell death, we have identified the minimal sequences of Bik, from a library of N-terminal and C-terminal deletion mutants, required for interaction with Bcl-2 and Bcl-xL and for inducing efficient cell death. Two-hybrid analysis in yeast and immunoprecipitation analysis of proteins expressed in mammalian cells indicate that a 52-amino acid region (amino acids 43-94) of Bik, encompassing the BH3 domain, is sufficient for efficient heterodimerization with Bcl-2 and Bcl-xL. Protein interaction studies further reveal that an 18-amino acid region, encompassing the BH3 domain (residues 57-74), constitutes the core heterodimerization domain. Functional analysis indicates that a Bik deletion mutant expressing residues 43-120, which efficiently heterodimerizes with the anti-apoptosis proteins Bcl-2 and Bcl-xL, is defective in eliciting cell death. In contrast, a mutant expressing additional C-terminal sequences (amino acids 43-134) interacts with the survival proteins and elicits efficient cell death. Our results suggest that for Bik-mediated cell death, the heterodimerization activity encoded by the BH3 domain alone is insufficient and raise the possibility that Bik may induce cell death autonomous of heterodimerization with survival proteins such as Bcl-2 and Bcl-xL.
Combined-Modality Treatment for Resectable Metastatic Colorectal Carcinoma to the Liver: Surgical Resection of Hepatic Metastases in Combination With Continuous Infusion of Chemotherapy--An Intergroup Study (2002)

These data demonstrate that adjuvant intra-arterial and intravenous chemotherapy was beneficial in prolonging time to recurrence and pre-venting hepatic recurrence after hepatic resection of colorectal cancer.
An offset compensated fully differential CMOS current comparator (2002)

A novel fully-differential current comparator is proposed which is based on a double folded-cascode structure. Thanks to an offset and charge-injection compensation, it provides a sensitivity as good as 20 nA. Moreover, it achieves a switching time better than 30 ns with a 0.5-/spl mu/A input step current while dissipating 45 /spl mu/W.
Range image super-resolution via guided image filter (2012)

In this paper, we propose a novel method for solving range image super resolution problem. Given a low resolution range image as input, we recover a high resolution range image using a registered and potentially high resolution camera image of the same scene. We solve this range image super resolution problem by combining the advantages of guided image filter and reconstruction constrain. Specifically, based on the fact that discontinuities in range and coloring tend to co-align, we apply the guided image filter to integrate the registered high resolution camera image into the range data and generate an initial high resolution range image. Moreover, a reconstruction constraint is also used to further improve the quality of the initial high resolution range image iteratively. Experiments demonstrate that our approach can get excellent high resolution range image in terms of both its spatial resolution and depth precision.
The design of HMM-based banknote recognition system (2009)

The banknote recognition system based on hidden Markov models (HMM) is proposed. It is based on the empirical risk minimization (ERM) principle. Image preprocessing includes brightness equalization and tilt correction. In order to satisfy the high speed and reliability of the banknote processing system, the grid segmentation is used for features extraction. Analyze the experimental data and determine the number of states, iterations, and Gaussian components. The proposed banknote recognition system can be applied to classify any kinds of banknotes. More than 16,000 RMB samples are sampled by CIS (Contact Image Sensor) with 25 dpi. Experimental results show that the proposed method obtained higher recognition rate than ANN and SVM.