gebhart/patrepeval huggingface dataset:
Filling of a complex‐shaped mold with a viscoelastic polymer. Part II: Comparison with experimental data (1993)

Abstract An experimental program has been carried out on a reciprocating screw injection molding machine in order to establish the validity of a proposed mathematical model for the filling stage of injection molding. A cavity of complex shape with an insert and variable thickness was constructed and used in these experiments. Good agreement between predicted (through computer simulation) and observed (through short‐shot experiments and transducer response) results is obtained for free surface shapes and free surface locations with time. The theoretical pressure predictions are in fairly good agreement with experiments, with the maximum deviations occurring towards the end of filling and for longer filling times. This points towards the possibility that wall solidification during filling interacts with the flow processes across the gap of the cavity and makes necessary a more detailed characterization of the heat transfer at the melt/mold interface.
Guanosine Diphosphate- <scp>l</scp> -Fucose Glycopeptide Fucosyltransferase Activity in <i>Corynebacterium insidiosum</i> (1973)

The biosynthesis of a phytotoxic glycopeptide of Corynebacterium insidiosum involves guanosine diphosphate-l-fucosyltransferase activity. This enzyme activity is most consistently associated with the cellular membranes fraction. The optimal pH for the transfer reaction is 7.5. The partially hydrolyzed toxin serves as an acceptor (primer) of l-fucose.
Silver–magnesium fluoride cermet films 1: Preparation and microstructure (1989)

We have prepared and studied seventeen thin films ranging in composition from pure silver to pure magnesium fluoride. Using mass thicknesses based on quartz crystal oscillators and physical thicknesses obtained from a stylus profilometer, we have measured the void volume fraction of the films as a function of their composition. We have shown the Ag–MgF2 system to be capable of incorporating a high volume fraction of voids. We report on the results of electron microscope studies of the films, which show the dependence of film microstructure on composition, thickness, and the nature of its substrate.
The chemistry of the pyrrocolines. Part VII. Further experiments with 2-methylpyrrocoline (1955)

D. O. Holland and J. H. C. Nayler, J. Chem. Soc., 1955, 1504 DOI: 10.1039/JR9550001504
Ecology of Tridacna in Palau (1969)

Species composition, distribution, standing crop biomass, spawning, and growth rate of Tridacnidae clams were studied in Palau, Western Caroline Islands. The population was composed of six species: Tridama gigas, T. derasa, T. squamosa, T. maxima, T. crocea, and Hippopus hippopus. In random transects, T. crocea was the most frequent and abundant, while T. derasa and T. gigas made up the largest proportion of the standing crop biomass. Spawning was induced artificially in T. squamosa by addition of macerated gonad from one individual to an aquarium containing other individuals, but larval development was not observed. The growth rate of tagged Tridacnidae was slow and further study will be required before an estimate of biomass production can be derived.
Biomechanics and Biocompatibility of Woven Spider Silk Meshes During Remodeling in a Rodent Fascia Replacement Model (2013)

Hand-manufactured spider silk meshes with good biocompatibility and beneficial mechanical properties seem superior to standard biological and synthetic meshes, implying an innovative alternative to currently used meshes for hernia repair.
Occurrence of selected flower head insects of Centaurea solstitralis in Italy and Greece (1988)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Transcriptome‐wide analysis of the <scp>MADS</scp>‐box gene family in the orchid <i><scp>E</scp>rycina pusilla</i> (2015)

Orchids exhibit a range of unique flower shapes and are a valuable ornamental crop. MADS-box transcription factors are key regulatory components in flower initiation and development. Changing the flower shape and flowering time can increase the value of the orchid in the ornamental horticulture industry. In this study, 28 MADS-box genes were identified from the transcriptome database of the model orchid Erycina pusilla. The full-length genomic sequences of these MADS-box genes were obtained from BAC clones. Of these, 27 were MIKC-type EpMADS (two truncated forms) and one was a type I EpMADS. Eleven EpMADS genes contained introns longer than 10 kb. Phylogenetic analysis classified the 24 MIKC(c) genes into nine subfamilies. Three specific protein motifs, AG, FUL and SVP, were identified and used to classify three subfamilies. The expression profile of each EpMADS gene correlated with its putative function. The phylogenetic analysis was highly correlated with the protein domain identification and gene expression results. Spatial expression of EpMADS6, EpMADS12 and EpMADS15 was strongly detected in the inflorescence meristem, floral bud and seed via in situ hybridization. The subcellular localization of the 28 EpMADS proteins was also investigated. Although EpMADS27 lacks a complete MADS-box domain, EpMADS27-YFP was localized in the nucleus. This characterization of the orchid MADS-box family genes provides useful information for both orchid breeding and studies of flowering and evolution.
Domain-Specific Incorporation of Noninvasive Optical Probes into Recombinant Proteins (2004)

An integrated approach is described that allows the domain-specific incorporation of optical probes into large recombinant proteins. The strategy is the combination of two existing techniques, expressed protein ligation (EPL) and in vivo amino acid replacement of tryptophans with tryptophan (Trp) analogues. The Src homology 3 (SH3) domain from the c-Crk-I adaptor protein has been labeled with a Trp analogue, 7-azatryptophan (7AW), using Escherichia coli Trp auxotrophs. Structural, biochemical, and thermodynamic studies show that incorporation of 7AW does not significantly perturb the structure or function of the isolated domain. Ligation of the 7AW-labeled SH3 domain to the c-Crk-I Src homology 2 (SH2) domain, via EPL, generated the multidomain protein, c-Crk-I, with a domain-specific label. Studies of this labeled protein show that the biochemical and thermodynamic properties of the SH3 domain do not change within the context of a larger multidomain protein. The technology described here is likely to be a useful tool in enhancing our understanding of the behavior of modular domains in their natural context, within multidomain proteins.
Bending Crash Behaviour of Foam-Filled Rectangular Magnesium Alloy AZ31 B Tubes (2015)

Quasi-static/dynamic three-point bending tests were conducted to assess the crash
performance of magnesium alloy AZ31B extruded and sheet tubes at the German Aerospace Centre
(DLR) – Institute of Vehicle Concepts in Stuttgart. Different foam-filled AZ31B beams with a
variation of foam density and thickness were fabricated through several manufacturing processes:
cold bending, tungsten inert gas welding, cathodic dip painting and polyurethane foam injection. The
experimental results were compared with those from mild steel DC04 tubes. It shows that empty
magnesium alloy AZ31B outperforms steel DC04 in terms of specific energy absorption for the empty
tubes with equivalent volume when subjected to bending loads. It was found that the foam-filled tubes
achieved much higher load carrying capacity and specific energy absorption than the empty tubes.
Moreover, there is a tendency showing that a foam-filled beam with a higher foam density reaches
higher load carrying capacity, but fractures earlier. The foam-filled AZ31B tube with 0.20 g/cm3 foam
obtained the highest specific energy absorption, but this outperformance was weakened due to the
earlier fracture. In addition, the numerical simulation utilising material model MAT_124 in
LS-DYNA explicit FEA package was performed. The simulation results indicate that using calibrated
stress-strain curves and failure parameters, material model MAT_124 yields a general good
agreement with the experimental results.
Examination of Near Surface Alignment in Tilted Smectic Liquid Crystal Filled Cells (1991)

Abstract The structure of the near surface director profile in a tilted smectic liquid crystal cell is of interest to the understanding of surface alignment. Here this is investigated for low and high surface tilt SiO alignments using the technique of evanescent field polarization conversion. Comparison between the observed conversion and that predicted theoretically allows the near surface structure to be probed. For low surface tilt a boundary layer is found over which reorientation to the surface alignment direction takes place. For high tilt alignment the liquid crystal surface has large twist angles, with only a very thin layer of reorganization to the surface alignment direction still present.
Theoretical investigation of the structure and electronic properties of poly(dithieno[3,4-b:3',4'-d]thiophene), a small-band-gap conjugated polymer (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheoretical investigation of the structure and electronic properties of poly(dithieno[3,4-b:3',4'-d]thiophene), a small-band-gap conjugated polymerC. Quattrocchi, R. Lazzaroni, J. L. Bredas, R. Zamboni, and C. TalianiCite this: Macromolecules 1993, 26, 6, 1260–1264Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ma00058a010https://doi.org/10.1021/ma00058a010research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interferon and Antiallergic Drug Regulation of Histamine and Tumor Necrosis Factor-α in Rat Mast Cell Subsets (1995)

We have further characterized the heterogeneity of mast cells (MCs) by comparing the ability of rat peritoneal MCs (PMCs) and intestinal mucosal MCs (IMMCs) to produce tumor necrosis factor (TNF)-alpha and by investigating its regulation by interferon (IFN) and the antiallergic drugs nedocromil sodium (NED) and sodium cromoglycate (SCG). Although IMMCs store less TNF-alpha than PMCs, they produced comparable amounts of TNF-alpha in cytotoxic assays. Just as SCG and NED inhibit histamine secretion from PMCs but not IMMCs, IFN exhibited a similar differential effect on histamine release from these cells. However, SCG, NED, and IFN inhibit TNF-alpha-dependent cytotoxicity by both PMCs and IMMCs and reduce the steady-state levels of mRNA for TNF-alpha in PMCs. Thus, the modulation of MC mediator release depends upon the MC population and mediator studied. The inhibitory effect of SCG and NED on TNF-alpha release from MCs may explain some of their anti-inflammatory and therapeutic effects.
Alteration by valinomycin of 45calcium handling in isolated islets (1978)

SCOPUS: NotDefined.j
Use of Wrapper Algorithms Coupled with a Random Forests Classifier for Variable Selection in Large-Scale Genomic Association Studies (2009)

Modern large-scale genetic association studies generate increasingly high-dimensional datasets. Therefore, some variable selection procedure should be performed before the application of traditional data analysis methods, for reasons of both computational efficiency and problems related to overfitting. We describe here a "wrapper" strategy (SIZEFIT) for variable selection that uses a Random Forests classifier, coupled with various local search/optimization algorithms. We apply it to a large dataset consisting of 2,425 African-American and non-Hispanic white individuals genotyped for 4,869 single-nucleotide polymorphisms (SNPs) in a coronary heart disease (CHD) case-cohort association study (Atherosclerosis Risk in Communities), using incident CHD and plasma low-density lipoprotein (LDL) cholesterol levels as the dependent variables. We show that most SNPs can be safely removed from the dataset without compromising the predictive (classification) accuracy, with only a small number of SNPs (sometimes less than 100) containing any predictive signal. A statistical (SUMSTAT) approach is also applied to the dataset for comparison purposes. We describe a novel method for refining the subset of signal-containing SNPs (FIXFIT), based on an Extremal Optimization algorithm. Finally, we compare the top SNP rankings obtained by different methods and devise practical guidelines for researchers trying to generate a compact subset of predictive SNPs from genome-wide association datasets. Interestingly, there is a significant amount of overlap between seemingly very heterogeneous rankings. We conclude by constructing compact optimal predictive SNP subsets for CHD (less than 150 SNPs) and LDL (less than 300 SNPs) phenotypes, and by comparing various rankings for two well-known positive control SNPs for LDL in the apolipoprotein E gene.
Estimation of Infarct Size in Man and its Relation to Prognosis (1972)

Infarct size was assessed quantitatively in 33 patients with acute myocardial infarction with a new technic based on analysis of serial serum creatine phosphokinase (CPK) changes to determine its relationship to prognosis. We have recently measured infarct size in the conscious dog with this method which takes into account CPK distribution space, fractional disappearance rate, proportion degraded in myocardium, and proportion released into the circulation, and we have validated the method by measurement of myocardial CPK depletion in the same animals. In the present study, CPK activity (determined spectrophotometrically) and isoenzyme profiles (assayed electrophoretically) were measured in patient serum samples obtained every 2 hours. Infarct size was estimated by mathematical analysis of serial CPK changes utilizing the method previously developed in the conscious dog model. CPK isoenzyme profiles demonstrated prominent anodal bands, absent from normal serum, indicating that enzyme elevations reflected CPK released from heart rather than skeletal muscle. In 19 class I-II survivors (New York Heart Association) estimated infarct size was 31 ± 4 CPK-gram-equivalents (CPK-g-Eq). It was significantly larger ( P < 0.01), 103 ± 14, in nine patients who died and in four class III or IV survivors (91 ± 8). Estimation of cumulative infarct size differentiated patients with electrocardiographic changes and clinical sequelae from complications such as pericarditis from those patients with extension of infarction. Thus, infarct size can be assessed quantitatively in patients with acute myocardial infarction and provide a useful diagnostic and prognostic index based on the extent of myocardial damage.
Individual patient data-based meta-analysis assessing pre-operative chemotherapy in resectable oesophageal carcinoma (2007)

4512 Background: Optimal management of operable localised oesophageal carcinoma remains to be determined. The debate is fuelled by some positive individual trials showing a benefit of preoperative chemotherapy (CT+S) or preoperative chemo-radiotherapy (CRT+S) over surgery alone (S). Our group has initiated an individual patient data-based meta-analysis to quantify the potential benefit of CT+S over S. Methods: The methodology used for trial identification and data analysis has been previously reported. The primary endpoint was overall survival (OS). The secondary endpoints were disease-free-survival (DFS) analyzed with a 6 months landmark method, tumour resectability (complete resection rate) and post-operative mortality. The logrank-test, stratified by trial, and hazard ratio (HR) were used for comparison. Subgroup analyses by age, sex, performance status, and histologic type were prospectively planned. Results: Twelve eligible randomized trials (2,284 patients) were identified. Individual patient data from 9 trials (2,102 patients) with a median follow-up of 5.3 years were available for the OS analysis. There was a statistically significant OS benefit in favour of CT+S (HR=0.87, 95% CI 0.79–0.95, p=0.003) translating into a 5-year absolute OS increase of 4% (from 16 to 20%). Based on 7 trials (1,849 patients), the HR for DFS was 0.82 (95% CI 0.74–0.91, p=0.001) in favour of CT+S, representing a 5-year absolute DFS benefit of 4% (from 6 to 10%). The complete resection rate across 8 trials (1,933 patients) was significantly greater in the CT+S arm (67%) compared to the S arm (62%) (OR=0.81, 95% CI 0.67–0.98, p=0.03). No difference was seen in postoperative death (6.7%). No interaction between treatment effect and patients characteristics was seen. Conclusions: Individual patient data-based meta-analysis represents the highest level of evidence and this study shows a small but significant overall and disease-free survival benefit in favour of preoperative chemotherapy over surgery alone. Unrestricted grants from LNCC and Sanofi-Aventis. No significant financial relationships to disclose.
Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein. (1991)

Rapamycin is a macrolide antifungal agent with structural similarity to FK506. It exhibits potent immunosuppressive properties analogous to those of both FK506 and cyclosporin A (CsA). Unlike FK506 and CsA, however, rapamycin does not inhibit the transcription of early T-cell activation genes, including interleukin-2, but instead appears to block downstream events leading to T-cell activation. FK506 and CsA receptor proteins (FKBP and cyclophilin, respectively) have been identified and shown to be distinct members of a class of enzymes that possess peptidyl-prolyl cis-trans isomerase (PPIase) activity. Despite the apparent differences in their mode of action, rapamycin and FK506 act as reciprocal antagonists in vivo and compete for binding to FKBP. As a means of rapidly identifying a target protein for rapamycin in vivo, we selected and genetically characterized rapamycin-resistant mutants of Saccharomyces cerevisiae and isolated a yeast genomic fragment that confers drug sensitivity. We demonstrate that the resonse to rapamycin in yeast cells is mediated by a gene encoding a 114-amino-acid, approximately 13-kDa protein which has a high degree of sequence homology with human FKBP; we designated this gene RBP1 (for rapamycin-binding protein). The RBP1 protein (RBP) was expressed in Escherichia coli, purified to homogeneity, and shown to catalyze peptidyl-prolyl isomerization of a synthetic peptide substrate. PPIase activity was completely inhibited by rapamycin and FK506 but not by CsA, indicating that both macrolides bind to the recombinant protein. Expression of human FKBP in rapamycin-resistant mutants restored rapamycin sensitivity, indicating a functional equivalence between the yeast and human enzymes.
Nonlocal Characteristics of the Bulk Upper Critical Field of Niobium (1970)

Measurements of the anisotropic critical field ${H}_{c2}$ of Nb at temperatures down to 0.06 K show that its temperature dependence contains a logarithmic factor as predicted by Gor'kov on the basis of a nonlocal theory for an isotropic type-II superconductor. The critical field extrapolated to zero temperature, when averaged over all crystallographic directions and normalized to the slope of the critical field for $T\ensuremath{\approx}{T}_{c}$, has an enhancement close to that predicted by the Hohenberg-Werthamer calculation for the nonlocal effects of Fermi-surface anisotropy, as evaluated by Mattheiss for a band model of niobium.
Pharmacology of mifentidine, a novel H2-receptor antagonist. (1985)

N1-[(4-Imidazolyl)-phenyl]-N2-isopropylformamidine (mifentidine, DA 4577 is a potent and selective H2 antagonist, representative of a new class of compounds, the imidazolylphenyl-formamidines, characterized by a semi-rigid structural conformation. Mifentidine appeared to be a specific and competitive antagonist of several histamine-mediated responses. Thus, in isolated guinea pig atria and ventricles it antagonized histamine chronotropic and dimaprit inotropic effects in a competitive manner providing affinity estimates (pA2) of 7.66 and 7.74, respectively. Mifentidine exerted potent antisecretory effects in: the isolated mouse stomach where it antagonized the acid promoting activity of histamine (EC50 3.28 mumol/l) but not that of bethanechol or db-cAMP (adenosine 3',5'-monophosphate); the lumen perfused stomach of the anaesthetized rat, inhibiting histamine (ED50 0.1 mumol/kg i.v.) and pentagastrin (ED50 0.2 mumol/kg i.v.) stimulated secretion; the pylorus ligated rat (ED50 1.35 mumol/kg i.v.); the gastric fistula dog, reducing the secretagogue effect of pentagastrin (ED50 96 nmol/kg i.v.); the conscious dog equipped with the Heidenhain pouch, where it was effective both following intravenous (ED50 119.7 nmol/kg) and oral administration (ED50 323.8 nmol/kg) in antagonizing histamine action. Mifentidine antisecretory effect, examined in the dog, appeared to last for a significantly longer time than that of ranitidine. Mifentidine was free of cardiovascular effects (on aortic blood pressure and heart rate) when administered repeatedly to the conscious dog at doses far above those needed to suppress acid secretion.
RNase1 as a potential mediator of remote ischaemic preconditioning for cardioprotection (2015)

Upon RIPC, the level of cardioprotective RNase1 increased, while the concentration of damaging eRNA and TNF-α decreased. The present findings imply a significant contribution of the RIPC-dependent (endothelial) RNase1 for improving the outcome of cardiac surgery. However, the exact mechanism of RNase1-induced cardioprotection still remains to be explored.
Measurements of the rotordynamic shroud forces for centrifugal pumps (1990)

An experiment was designed to measure the rotordynamic shroud forces on a centrigual pump impeller. The measurements were doen for various whirl/impeller ratios and for different flow rates. A destabilising tangential force was measured for small positive whirl ratios and this force decreased with increasing flow rate.