gebhart/patrepeval huggingface dataset:
H-Infinity motion control system for a 2 m telescope (2002)

The design of high performance motion control systems for large telescopes is an area of major interest. To counteract the effects of parameter variations and uncertainties as well as wind buffeting a robust controller must be designed. This paper outlines an approach for designing H-infinity controllers for the main axes of a class of telescopes. Some choices made during the controller design are briefly considered. The impact on system performance arising from structural resonance, wind buffeting, drive train stiffness and drive stiction are discussed. The controllers are developed from state space models that include wind disturbances. Davenport wind power spectrum is used to characterize wind buffeting. Sub-optimal H-infinity controllers are designed using standard tools in Matlab. The controllers are designed to operate in continuous time but for implementation they are discretized with a sampling time interval of 2.5 milliseconds. Experimental results for both azimuth and altitude are presented and discussed. A summary of RMS servo errors for tracking and pointing is also included.
Selective Synthetic Transformations Based on Vanadium‐Mediated Redox Reactions (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Clinical Diabetes Research: Methods and Techniques. Edited by Michael Roden. © 2007, John Wiley & Sons Ltd ISBN: 978 0 470 01728 9 (2008)

Clinical Diabetes Research: Methods and Techniques. Edited by Roden, Michael, © 2007, John Wiley & Sons Ltd. Cloth £85.00. ISBN 978 0 470 01728 9 Gerald F Watts Professor of Medicine*, * Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Australia Professor Michael Roden has marshalled a team of experts, mostly from European academic centres, that has produced a comprehensive and detailed account of a wide spectrum of techniques in diabetes and metabolic research. Six chapters are devoted to techniques for studying intermediary metabolism, specifically beta-cell function, insulin resistance, glucose kinetics, and counter-regulatory response to hypoglycaemia. The remainder of the chapters focus on lipid and protein metabolism, new imaging techniques in metabolic research, use of tissue biopsies, methods for studying arterial function, neuropathy, nephropathy and retinal disease, and basic molecular genetics, with the final chapters covering Good Clinical Practice and general statistical methods. While the overall material is comprehensive, some of the chapters, particularly those dealing with xenobiotic probes and with protein and amino acids kinetics, tend to lack an explicit diabetic context, while others are well focused on diabetes. Also, there are some important omissions, such as chapters on apolipoprotein kinetics, use of echocardiography to study cardiac function, tests for investigating gastric emptying in autonomic neuropathy, nutritional methods in clinical research, techniques for assessing haemostasis and coagulation, and the use of metabolomics. These omissions should not detract from the excellence of this volume. The material presented will be of interest to established researchers in the field, as well as to PhD students and postdoctoral research fellows. I strongly recommend that this book be purchased by all diabetes and endocrine departments undertaking human diabetes research.
Effects of placental tissue on immunological responses. (1978)

Using in vivo assays for alloreactivity, the responsiveness of maternal lymph node cells was shown to be increased when cells were harvested from both syngeneically and allogeneically pregnant mice. In addition, foetal liver and thymus cells induced a state of delayed type hypersensitivity to alloantigens whereas trophoblastic tissue, in the form of 12 to 15 day metrial glands, did not. The influence of mouse placenta on in vitro immune responses was tested using 7-day ectoplacental cones as sources of trophoblastic tissue. Ectoplacental cones increased a T cell dependent but not a T cell independent antibody response, whereas T cell dependent cytotoxicity was reduced. The findings reported in this paper suggest that murine ectoplacental cones are a particularly useful tissue with which to study both specific and non-specific immunological activities of the trophoblast in syngeneic and allogeneic pregnancies.
Registry for torsades de pointes with drug treatment exists (2001)

EDITOR—The editorial by Yap and Camm provided an excellent overview of the subject of medication-induced long QT syndrome and made two important practical recommendations, regarding which we wish to report progress.1

They recommended that any adverse event suggestive of cardiac arrhythmias related to drug treatment should be urgently reported to drug safety authorities and drug …
Influence of Edaphic Factors and Previous Crop on Pratylenchus spp. Population Densities in Potato. (1987)

Root and soil samples from commercial potato fields were assayed for nematodes in 1983 and 1984. Pratylenchus spp. population densities in Suffolk County, New York, were consistently, though not always statistically, higher in potato fields that had been planted to rye or wheat rather than potatoes during the previous growing season. Regardless of the previous crop, population densities in the two potato production areas in Suffolk County differed significantly: population densities on the south fork were 1.9-5.5 times higher than those on the north fork. Species prevalence differed significantly on the two forks but was not related to the previous year's crop. P. penetrans and P. crenatus were found primarily on the north and south forks, respectively. Differences in species distribution were associated with differences in soil types. P. crenatus was usually found on loams and silt loams, but P. penetrans was found more frequently on sandy soils.
Genetic Profile of an Oka Varicella Vaccine Virus Variant Isolated from an Infant with Zoster (2004)

Varicella virus vaccine strain Oka (V-Oka) has in rare cases caused zoster in vaccinated people. Despite broad usage of V-Oka, little is known about varicella-zoster virus genomic sequence variation of strains in vaccine and isolates from patients with vaccine adverse events. Direct sequencing of 20 regions of V-Oka-GSK was compared to the sequences of the original V-Oka-Biken, GlaxoSmithKline Oka vaccine (V-Oka-GSK), and Oka-parental (P-Oka) strains. We analyzed single nucleotide polymorphisms (SNP) differentiating the Oka parental and Oka vaccine strains identified in open reading frames (ORFs) 6, 9A, 10, 21, 31, 39, 50, 51, 52, 54, 55, and 59 and eight base substitutions within ORF 62. Sixteen of these SNP impose an amino acid change in the corresponding gene product. The genotypic analysis revealed that (i) both V-Oka-GSK and V-Oka-Biken comprise mixtures of strains represented in variable proportion from lot to lot; (ii) V-Oka-GSK/zoster isolated from the zoster patient had six wild-type SNP in ORF 9A, 10, 21, 52, 55, and 62 (mutation 108838); (iii) none of the six revertant SNP would reliably discriminate Oka vaccine from the wild type; and (iv) the genomic variation found in V-Oka/zoster might be associated with changes in the biological behavior of the virus. Further studies will be needed to identify potential virulence factors in variant vaccine strains.
Engineering And Environmental Applications Of The Potential Field Methods Of Geophysics. (2007)

Gravity and magnetic methods are potential field methods and used for a wide range of applications and scales in geosciences. Traditionally, they have been used for regional, large scale investigation of geological structure, such as basement relief and fault structure delineation. Despite the initial contribution of gravity methods to oil/petroleum exploration by detection and mapping of salt domes, “gravity data” is viewed primarily as a “reconnaissance tool in oil exploration” and “to provide constraints in seismic interpretation.” (quotes from Telford et al.,<br>1990) A familiar, smaller-scale (higher resolution) application of the gravity and magnetic methods is for ore body detection and mapping. The key geological factor required for<br>application of the gravity and magnetic methods is lateral variation in physical properties of subsurface materials. If the only variation in physical properties is in the vertical direction, such<br>as is the case for horizontally layered, homogeneous strata, the gravity and magnetic methods are applicable only for confirmation of the uniformity and lack of anomalous conditions.<br>Engineering and environmental (near-surface) applications of the gravity and magnetic methods were limited prior to the 1960's. Equipment developments and the emergence of new<br>classes of high priority applications have brought about a resurgence of interest in the potential field methods of geophysics and the development of high-resolution, high-accuracy field<br>procedures. The new classes of applications can be summarized as environmental (hazardous and toxic waste site assessments), archaeological, abandoned mine lands reclamation, cavity and tunnel detection and mapping, site investigations in karst areas, seismotectonic investigations, and other specialized problems. The gravity and magnetic methods are noted for two facts, one positive and the other somewhat negative: (1) the methods, which rely on measurement of variation in a naturally occurring potential fields, are fundamentally non-invasive and nondisturbing; (2) the interpretation of survey results is complicated by the fundamental, inherent nonuniqueness or ambiguity of source determination. The inherent ambiguity of gravity and <br>magnetic interpretation often requires the exercise of more geological insight and constraining direct information, such as from boreholes, for quantitative interpretation than required by many<br>of the other geophysical methods (although in fact interpretation of all geophysical survey results involves varying degrees of nonuniqueness and ambiguity). For purely qualitative, anomaly<br>mapping applications, the gravity and magnetic methods often can be used when other geotechnical methods are not effective. And, with apologies for not including other near-surface<br>geophysical methods that are legitimately potential field methods, e.g., direct current resistivity and self-potential, this paper only addresses gravity and magnetic methods and their engineering and environmental applications.
Cloning and Characterization of a Novel Activating Ly49 Closely Related to Ly49A (1999)

The majority of the known Ly49 family members have been isolated from either C57BL/6 (B6) or BALB/c mice. Interestingly, the anti-Ly49 Ab reactivities observed in 129/J mice are different from those of B6 mice. Furthermore, immunoprecipitation of 129/J NK cell lysates with YE1/32 and YE1/48, Abs specific for the inhibitory Ly49A in B6, resulted in detection of the activation-associated DAP12 molecule. These results indicated a need for a more detailed study of this strain. Therefore, a cloning strategy was devised to isolate Ly49 cDNAs from 129/J mice. An immunoreceptor tyrosine-based inhibitory motif-containing, Ly49D-related clone was discovered that we have named Ly49O, and one immunoreceptor tyrosine-based inhibitory motif-lacking, Ly49A-related clone was discovered that we have named Ly49P. No anti-Ly49 mAb reacted with Ly49O, whereas the molecule encoded by the Ly49P cDNA was found to react with YE1/32 and YE1/48. Ly49P was found to associate with mouse DAP12, and Ab-mediated cross-linking of Ly49P resulted in mouse DAP12 phosphorylation and Ca2+ mobilization, indicating that Ly49P is a competent activation receptor. Ly49P, therefore, represents a novel member of the Ly49 activating receptor subfamily.
Identification of three essential lysine residues probably involved in substrate binding of the NAD+ - dependent glutamate dehydrogenase of <i>Clostridium symbiosum</i> (1988)

Conference Article| October 01 1988 Identification of three essential lysine residues probably involved in substrate binding of the NAD+ - dependent glutamate dehydrogenase of Clostridium symbiosum K. S. LILLEY; K. S. LILLEY 1Department of Biochemistry, University of Sheffield, Western Bank, Sheffield S10 27TN, U.K. Search for other works by this author on: This Site PubMed Google Scholar P. C. ENGEL P. C. ENGEL 1Department of Biochemistry, University of Sheffield, Western Bank, Sheffield S10 27TN, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1988) 16 (5): 875–876. https://doi.org/10.1042/bst0160875 Article history Received: April 04 1988 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation K. S. LILLEY, P. C. ENGEL; Identification of three essential lysine residues probably involved in substrate binding of the NAD+ - dependent glutamate dehydrogenase of Clostridium symbiosum. Biochem Soc Trans 1 October 1988; 16 (5): 875–876. doi: https://doi.org/10.1042/bst0160875 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: GDH, glutamate dehydrogenase, PalP, pyri-doxal 5′-phosphate This content is only available as a PDF. © 1988 Biochemical Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.
Solving the loss of orthogonality during the polyaddition of α‐azide‐ω‐alkyne monomers catalyzed by Cu(PPh<sub>3</sub>)<sub>3</sub>Br: Application to the synthesis of high‐molar mass polytriazoles (2010)

Abstract Polyaddition of an α‐azide‐ω‐alkyne monomer by Cu(PPh 3 ) 3 Br catalyzed 1,3‐dipolar cycloaddition was thoroughly studied as a model system to investigate the orthogonality of this click chemistry process. Indeed, loss of chain‐end functionality and occurrence of side reactions have a tremendous impact on the molar mass of polymers obtained by step growth polymerization. Particularly, SEC, 1 H, and 31 P NMR experiments have highlighted the occurrence of a Staudinger side‐reaction between azide chain‐ends and PPh 3 from the copper(I) catalyst that dramatically alters M n of the resulting polytriazoles. A significant enhancement of M n could be achieved by using an alternative catalyst and optimized experimental conditions, that is, dilution and reaction time. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 2470–2476, 2010
Reversible tubular dysfunction in alcohol abuse. (1985)

The discovery of an unexplained alkaline urine pH in a significant percentage of chronic alcoholic patients prompted us to evaluate some aspects of their tubular function. We studied 60 patients with a history of alcohol consumption of at least 160g daily for 10 years or more. Only patients without clinical and histopathological evidence of chronic liver disease were included in the study. The endogenous creatinine clearance was in the normal range in all patients. On the first day of hospitalisation 22 patients (36.6%) had a urine pH greater than 6.4 and a daily bicarbonate excretion ranging from 5.8 to 25.9mmol. The fractional urinary excretion of beta 2-microglobulin, sodium, potassium, chloride, calcium, phosphorus and uric acid were significantly increased compared with those of 38 alcoholic patients with urine pH less than 6.4 and those of 50 healthy controls. All these indices of tubular function improved during withdrawal, and after 30 days of abstinence their values did not differ from those of controls. This data provides evidence that in one-third of heavy drinkers alcohol abuse causes a complex tubular dysfunction which, at least in this stage of alcoholic disease, recovers with abstinence.
Structure and Bonding in Amorphous Cr<sub>1–<i>x</i></sub>C<sub><i>x</i></sub> Nanocomposite Thin Films: X-ray Absorption Spectra and First-Principles Calculations (2016)

The local structure and chemical bonding in two-phase amorphous Cr1−xCx nanocomposite thin films are investigated by Cr K-edge (1s) X-ray absorption near-edge structure (XANES) and extended X-ray absorption fine structure (EXAFS) spectroscopies in comparison to theory. By utilizing the computationally efficient stochastic quenching (SQ) technique, we reveal the complexity of different Cr-sites in the transition metal carbides, highlighting the need for large scale averaging to obtain theoretical XANES and EXAFS spectra for comparison with measurements. As shown in this work, it is advantageous to use ab initio theory as an assessment to correctly model and fit experimental spectra and investigate the trends of bond lengths and coordination numbers in complex amorphous materials. With sufficient total carbon content (≥30 at. %), we find that the short-range coordination in the amorphous carbide phase exhibit similarities to that of a Cr7C3 ± y structure, while excessive carbons assemble in the amorphous carbon phase.
Measuring phase with Stokes measurements (2014)

59th South African Institute of Physics conference, University of Johannesburg, 8 July 2014.
Local indices of aortic stiffness a magnetic resonance imaging study (2009)

The stiffness of the aortic wall was evaluated by coupling the morphological and the blood flow MR data. The deformability of the ascending aorta, and the aortic Pulse Wave Velocity (PWV) were estimated in a series of 36 volunteers aged between 14 and 77 years. An accurate automatic method of segmentation for extracting contours of the aorta was used. A 3D estimation of the length of the aortic arch and a precise measurement of the transit time between ascending and descending flow waves were performed. Results. The deformability and the PWV were inversely related. Mean ± SD values of deformability and PWV for the younger subjects (age≪50) were respectively 0.25±0.11 and 4.03±0.83m/s. For the older subjects (age≥50) they were 0.068±0.04 and 7.01±1.14m/s. Conclusions. The local and automated approach for measurement of deformability and PWV characterizes directly the stiffness of the aorta and results are consistent with previous studies.
A New Method of Tearing Loops in Recycle Systems-A Successive Graph Core Expansion Method (1983)

Par cette methode on obtient a la fois les solutions optimales et des solutions presque optimales
State-of-the-Art Fusion-Finder Algorithms Sensitivity and Specificity (2013)

The discordant results obtained using synthetic and real datasets suggest that synthetic datasets encompassing fusion events may not fully catch the complexity of RNA-seq experiment. Moreover, fusion detection tools are still limited in sensitivity or specificity; thus, there is space for further improvement in the fusion-finder algorithms.
Terminal Area Energy Management Trajectory Planning for an Unpowered Reusable Launch Vehicle (2004)

A guidance scheme that employs a trajectory-planning algorithm has been developed for the terminal area energy management phase of an unpowered reusable launch vehicle. The trajectory-planning scheme computes a reference flight profile by piecing together several flight segments that are defined by a small set of geometric parameters. Iterating on three geometric parameters and propagating a test matrix of trajectories produces a set of feasible reference profiles that bring the vehicle from its current state to a desired approach and landing target state. Path constraints on states and controls are easily implemented in the propagation scheme, and simple numerical sorting is used to identify the optimal feasible path. Open- and closed-loop guidance commands are readily available once the best reference trajectory is determined. The trajectory-planning algorithm is able to quickly generate new reference profiles for test cases with large variations in initial vehicle energy, initial heading, and vehicle drag. The effectiveness of the trajectory-planning algorithm is demonstrated by several numerical simulations, which show that the guided vehicle is able to successfully reach the desired approach and landing glideslope target with small tracking errors.
Inertial sensor based object tracking method for video based technical support system (2015)

Recently, live video streaming from hand- held devices entered mass market. Ordinary video conference systems were supplemented with additional features, such as marking in order to point attention of the conference participants on specific object in the video. However, the accuracy of live video marking depends on the video latency, received between two video conference participants. The aim of this study was to propose a solution to synchronise video object coordinates in two video streams: transmitted and received with latency that is close to 2 seconds. A new system was proposed in this paper designed to track an object in the video stream based on the inertial sensor data. It was found that the displacement of the object of interest during latency interval could be predicted by the use of inertial sensors of the handheld device with 86% accuracy in average.
Rewriting as a unified model of concurrency (1991)

The lecture given at the workshop was based on recent work published elsewhere [9, 10, 8, 7]. This abstract gives a brief description of the main results and ideas presented in that work, but does not provide any technical details; such details can be found in the papers mentioned above.
Observations on compatibility between Bulinus truncatus and Schistosoma haematobium in the Senegal River Basin (1997)

In experiments to determine the compatibility between isolates of Schistosoma haematobium and Bulinus truncatus from Mali and Senegal, the parasite isolates were shown to differ in their intermediate host specificity. Bulinus truncatus from the Lower and Middle Valleys (Senegal) and the Upper Valley (Mali) of the Senegal River Basin (SRB) were all susceptible to S. haematobium isolated from the urines of children living in Tenegue, Office du Niger, Mali. However, none of the B. truncatus tested was susceptible to a parasite isolated from children living in Mbodiene, a village in the Lower Valley of the SRB, where natural transmission is normally associated with B. globosus. As B. truncatus is widely distributed in the SRB, the possible appearance of a Bulinus-truncatus-borne parasite in the Middle and Lower Valleys should be carefully monitored.
New synthesis of 1-β-<scp>D</scp>-arabinofuranosyl-aminoimidazoles and of related purine nucleosides (1978)

Ethyl 5-amino-1-β-D-arabinofuranosylimidazole-4-carboxylate has been prepared by condensation of 2,3,5-tri-O-benzyl-α-D-arabinofuranosyl chloride with ethyl 5-aminoimidazole-4-carboxylate and hydrogenation of the tri-O-benzyl derivative so formed with palladium on barium sulphate; the structure of the imidazole nucleoside was confirmed by conversion into the known 9-β-D-arabinofuranosyl hypoxanthine.
Conditional Gene Expression and Knockdown Using Lentivirus Vectors Encoding shRNA (2008)

Drug-inducible systems allowing the control of transgene expression and knockdown in mammalian cells are invaluable tools for genetic research, and could also play important roles in translational research or gene therapy. We and others have developed a lentivector-based, conditional gene expression system for drug-controllable expression of transgenes and small hairpin RNAs (shRNAs). This system is highly robust and versatile, governing tightly controlled expression of transgenes and endogenous cellular genes (through shRNAs) in various primary and established cell lines in vitro, as well as in vivo in the central nervous system or in human cancer cells xenotransplanted into nude mice. The goal of this article is to provide a concise methodology for construction and manipulation of this conditional lentiviral-based system, and quantitative analyses of drug-inducible transgene expression and gene knockdown both in vitro and in vivo.