gebhart/patrepeval huggingface dataset:
The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein. (1990)

Untransformed cytosol receptors for progesterone (PR), androgen (AR), estrogen (ER), and glucocorticosteroid (GR) in rabbit tissues contain a 59-kDa protein (p59) (Tai, P.K.K., Maeda, Y., Nakao, K., Wakim, N.G., Duhring, J.L., and Faber, L.E. (1986) Biochemistry 25, 5269-5275) and a 90-kDa heat shock protein (hsp90). In the present study, receptors from calf uterus (PR, AR, ER, and GR) and from human breast cancer MCF7 cells (PR and GR) were also shown to be comprised of hsp90 and p59. These heterooligomer receptor complexes were stabilized both by transition metal oxyanions (molybdate and tungstate) and chemical cross-linking with dimethylpimelimidate. In 0.4 M KCl, tungstate-stabilized (but not molybdate-stabilized) PR, AR, ER, and GR retained hsp90, but lost p59. Dimethylpimelimidate cross-linking prevented p59 dissociation from hsp90-receptor complexes. Stabilization with tungstate and/or cross-linking permitted immunoaffinity purification of untransformed rabbit as well as calf PR and ER on EC1-Affi-Gel 10 column (an anti-p59 immunoadsorbant). Combined immunoaffinity purification and cross-linking experiments indicated that p59 is bound to hsp90 in the cytosol. We propose that in the nontransformed steroid receptor, p59 interacts with hsp90 rather than with the hormone binding subunit.
Quasi-Brewster angle technique for evaluating the quality of optical surfaces (2004)

The requirements for optical surfaces have drastically increased for the deep-ultraviolet (DUV) and vacuum-ultraviolet (VUV) spectral regions. Low optical loss and laser durable fluoride optics are required for microlithographic applications. A nondestructive quasi-Brewster angle technique (qBAT) has been developed for evaluating the quality of optical surfaces including both top surface and subsurface information. The negative quasi-Brewster angle shift at wavelengths longer than 200 nm has been used to model the distribution of subsurface damage. By using effective medium approximation (EMA), the positive quasi-Brewster angle shift at wavelengths shorter than 200 nm has been explained by subsurface contamination. The top surface roughness (TSR) depicted by the qBAT is consistent with atomic force microscopy (AFM) measurements. The depth and the micro-porous structure of the subsurface damage measured by the qBAT, has been confirmed by magnetorheological finishing (MRF). The technique has been used to evaluate optically polished CaF<sub>2</sub> (111) and MgF<sub>2</sub> (001) surfaces.
Gobernanza, inteligencia artificial y justicia predictiva: Los retos de la administración de justicia ante la sociedad en red (2020)

El presente trabajo analiza los impactos que el proceso de implantacion de la Inteligencia Artificial en los sistemas judiciales y su entorno conlleva. Adopta, para ello, una triple perspectiva de analisis, considerando inicialmente el desarrollo historico de la jurisdiccion como potestad del Estado y, enseguida, examina las distintas perspectivas de la jurisdiccion, con una especial consideracion a la perspectiva constitucional y administrativa, para entonces examinar en profundidad la perspectiva administrativa. En dicho sentido, se examinan las atribuciones de los organos con competencias en materia de Administracion de Justicia en Espana, con vistas a comprender como el proceso de implantacion de la gobernanza y la digitalizacion de la Administracion y de la Administracion de Justicia han contribuido para el actual estado de desarrollo de la inteligencia artificial en este sector. Se realiza una profunda revision de la normativa de la Administracion de Justicia, particularmente las normas de caracter reglamentar dictadas por el Consejo General del Poder Judicial, asi como documentos de instituciones europeas. Dicha revision normativa y conceptual atiende a la necesidad de comprender que es la inteligencia artificial, su historico y posibilidades aplicativas en el ambito de la Administracion de Justicia, con vistas a comprender los retos que se presentan en el proceso de implantacion y en relacion con el marco regulatorio aplicable, contestando al cuestionamiento de si es suficiente una regulacion etica de la Inteligencia Artificial en la Administracion de Justicia y su entorno o si, en cambio, es indispensable una regulacion legal o reglamentar en dicho proceso.
The Surface Chemistry of Catalytic Reactions: Progress and Challenges (2015)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTThe Surface Chemistry of Catalytic Reactions: Progress and ChallengesFrancisco Zaera*View Author Information Department of Chemistry, University of California, Riverside, California 92521, United States*E-mail: [email protected]Cite this: J. Phys. Chem. Lett. 2015, 6, 20, 4115–4116Publication Date (Web):October 15, 2015Publication History Published online15 October 2015Published inissue 15 October 2015https://pubs.acs.org/doi/10.1021/acs.jpclett.5b02053https://doi.org/10.1021/acs.jpclett.5b02053editorialACS PublicationsCopyright © 2015 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1580Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (152 KB) Get e-AlertscloseSUBJECTS:Activation energy,Adsorption,Electrolytes,Interfaces,Metals Get e-Alerts
Inhibition of <i>Bacillus thuringiensis</i> proteases and their effects on crystal toxin proteins and cell-free translations (1988)

Proteases produced during growth and sporulation of four strains of Bacillus thuringiensis were examined. Low levels of proteolytic activity were detected during the late exponential phase of growth in all four strains: two strains of B. thuringiensis subsp. kurstaki and one strain each of subsp. israelensis and berliner. In all strains, protease activities increased dramatically at the onset of sporulation. The principal proteases, both extra- and intra-cellular, were neutral, metal-loproteases. The pH optima and substrate specificities of proteases extracted from cells in various stages of growth and sporulation indicated that substantial diversity existed among the strains. Intracellular proteases from all four strains converted the 135 000 molecular weight protoxin of strain HD251, an isolate previously shown to have reduced intracellular proteolytic activity and which normally does not contain a protein of the lower molecular weight, to a 68 000 molecular weight toxin. Cell-free translational activity of extracts from strain HD251 were approximately fivefold more active than were equivalent extracts from strain LB1 presumably because of the reduced intracellular proteolytic activity of this strain.
Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA (2017)

TAM-derived exosomes can inhibit the migration of endothelial cells by targeting the miR-146b-5p/TRAF6/NF-kB/MMP2 pathway. However, EOC-derived exosomes can transfer lncRNAs to remotely reverse this effect of TAMs on endothelial cells.
Microbial Biopesticides: The European Scene (2003)

There is growing interest in the exploitation of naturally occurring micro organisms for the control of crop pests, weeds, and diseases. Biological control agents (BCAs) may offer more environmentally friendly alternatives to chemical pesticides. They could also be used where pests have developed resistance to con ventional pesticides. Unfortunately, there is comparatively little investment in the research and development of these organisms compared with that spent on the discovery of chemical pesticides. Two reasons for this are that microbial pesticides usually have a narrow host range, and that they often give inconsistent and poor control in field trials. Consequently, more attention is being given to the selection of broad-spectrum biopesticides and improvements in production, formulation, and application technologies. Efforts are also being made to optimize the impact of these agents by integrating them with other novel crop protection strategies (1).
Study and application of military software pricing based on option pricing (2010)

The idea of real option is applied in military software pricing in this paper. By redefinition and combination of the two typical option pricing models (Black-Scholes model and binomial tree model), we find out that option value of military software is estimated software cost. Since the crucial variable of Black-Scholes model is the volatility whose value can be estimated with the method of Monte Carlo analogy. At last, the application of this military software pricing model is demonstrated in a real case.
Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation (2000)

In patients who are receiving mechanical ventilation, daily interruption of sedative-drug infusions decreases the duration of mechanical ventilation and the length of stay in the intensive care unit.
Sorting with associative secondary storage devices (1977)

A method for sorting large files stored on disks which possess an associative search capability is described. This method, called the bucket sort algorithm, uses a sort domain histogram to exploit the associative search capability. We discuss how to establish the sort domain histogram and analyze the performance of the bucket sort algorithm. Compared to the standard merge sort algorithm, this algorithm requires at most the processing time necessary for the initial run generation and the first pass of the merge operation. It also uses no disk storage space to store temporary results. The histogram creation process is analogous to Edelberg and Schissler's gyro sort algorithm which uses special hardware to rearrange data stored in electronic memory loops. The histogram creation process is more efficient than the gyro sort algorithm when each memory loop stores a large number of records and the distribution of sort domain values is not highly irregular.
The relationship between frontal sinus drainage and osteomeatal complex disease: a CT study in 217 patients. (1990)

Over a period of 2 years we reviewed the CT scans of 217 patients with recurrent sinusitis. Our findings revealed a number of cases of osteomeatal complex disease with no frontal sinus involvement. This result is difficult to reconcile with the concept of a common drainage in the middle meatus shared by the frontal and anterior ethmoid sinuses. We conclude that the frontal sinus drains separately from the other paranasal sinuses in a large percentage of cases, and that the frontal sinus is frequently spared when there is ethmoid or maxillary sinusitis.
Carbohydrate metal ion complexes. Interaction of <scp>D</scp>-glucono-1,5-lactone with Zn(II), Cd(II), and Hg(II) ions in the solid and aqueous solution, studied by <sup>13</sup>C-NMR, FT-IR, and X-ray powder diffraction measurements (1989)

D-Glucono-1,5-lactone interaction with zinc group metal ions has been studied in aqueous solution and solid salts of the type Zn(D-gluconate) 2 .2H 2 O, Cd(D-gluconate) 2 and Hg(D-gluconate) 2 have been isolated. These metal sugar salts were characterized by elemental analysis, 13 C-NMR, FT-IR spectroscopy, and X-ray powder diffraction measurements.X-ray powder diffraction diagrams and other spectroscopic evidence showed that Zn(D-gluconate) 2 .2H 2 O is isomorphous with the structurally identified Mn(D-gluconate) 2 .2H 2 O, suggesting a similar metal–sugar binding mode, through a carboxylate oxygen atom (O-1) and an OH group of the two sugars anions as well as to two H 2 O molecules, resulting in a six-coordinate Zn(II) ion. The Cd(II)- and Hg-D-gluconate salts are not similar and show dissimilarities to the Zn(II) compound. The Cd(II) ion binds to two D-gluconate anions possibly through the carboxylate O-1 and sugar O(2)—H, and O(3)—H groups of each anion, giving a six-coordinate Cd(II) ion. The Hg(II) ion is possibly four-coordinate, binding to two sugar anions via a carboxylate O-1 and O(2)—H groups of each D-gluconate anion. The zinc group metal-D-gluconate salts are aggregated through bridging sugar OCO − groups with sugar anion possibly having bent-chain conformation. Keywords: carbohydrate, metal ions, 13 C-NMR, FT-IR, X-ray powder diffraction.
Exclusivity-Consistency Regularized Multi-view Subspace Clustering (2017)

Multi-view subspace clustering aims to partition a set of multi-source data into their underlying groups. To boost the performance of multi-view clustering, numerous subspace learning algorithms have been developed in recent years, but with rare exploitation of the representation complementarity between different views as well as the indicator consistency among the representations, let alone considering them simultaneously. In this paper, we propose a novel multi-view subspace clustering model that attempts to harness the complementary information between different representations by introducing a novel position-aware exclusivity term. Meanwhile, a consistency term is employed to make these complementary representations to further have a common indicator. We formulate the above concerns into a unified optimization framework. Experimental results on several benchmark datasets are conducted to reveal the effectiveness of our algorithm over other state-of-the-arts.
Contribution of the ciliary cyclic nucleotide‐gated conductance to olfactory transduction in the salamander. (1993)

1. Flash photolysis of caged cyclic nucleotides was used to examine the contribution of the ciliary cyclic nucleotide-gated conductance to olfactory transduction in the tiger salamander. Brief illumination of solitary olfactory receptor cells loaded with 100 microM caged cyclic AMP caused a large inward current (peak amplitude 355 +/- 200 pA; mean +/- S.D. for eleven cells) under whole-cell voltage clamp at -50 mV. 2. The photolysis response was initiated after a latency of 4-12 ms, whereas an odorant response of identical amplitude had a latency of several hundred milliseconds. The amplitudes of both responses exhibited almost identical voltage dependence between -50 and +25 mV, with both reversing near 0 mV. The time courses of the falling phases of odorant and photolysis responses also exhibited similar voltage dependence, both being prolonged at positive voltages. 3. Photolysis of caged cyclic GMP activated a current similar in amplitude and time course to that produced by photolysis of caged cyclic AMP. 4. When the flash was spatially limited to the cilia, the amplitude and duration of the photolysis response increased linearly with the length of the cilia illuminated (for cilia not longer than 30-40 microns) while the latency remained constant at 4-12 ms. The increase in duration was described semi-quantitatively by a model which incorporated diffusion and saturable hydrolysis of cyclic AMP. When the flash was limited to the soma or proximal dendrite, the response latency was proportional to the square of the distance between the illuminated region and the cilia. 5. Dialysis of cells with 500 microM cyclic AMP from a whole-cell electrode under voltage clamp activated a large transient inward current. Simultaneous suction electrode recording showed that this current originated almost entirely from the ciliary membrane. The density of cyclic nucleotide-gated channels was estimated to be 800-fold higher in the cilia than in the soma. 6. Summation of simultaneous odorant and photolysis responses was non-linear, the flash-induced current being enhanced during a small odorant response and attenuated during a large odorant response. Summation of two photolysis responses was similarly non-linear. The data were consistent with odorant stimuli and cyclic AMP both activating a common cyclic nucleotide-gated conductance with a Hill coefficient, n, of 2.0-4.4. For n = 2.5, the basal cyclic AMP concentration was estimated to be less than 20% of the K 1/2, which predicts a basal current of 5.8 pA, less than 2% of the maximum.(ABSTRACT TRUNCATED AT 400 WORDS)
Alternating measurement of ambient and cabin ozone concentrations in commercial jet aircraft. (1978)

Ambient and cabin-air ozone concentrations were determined with an adapted commercial ozone analyzer installed in a KLM DC-10 from Amsterdam to Toronto and back. Cabin levels were detected directly and almost continuously; ambient levels were measured using a sampling system in which the ambient samples were converted to the cabin pressure at intervals of 13 min. A correlation is demonstrated between the ambient level, the cabin level, and the tropopause height. It was found that 70% of the ambient ozone concentration enters the cabin through the ventilation system, and about 50% of this concentration was measured 1.20 m above the cabin floor. For about 50% of the total flying time, the ozone level exceeded 200 parts per billion, by volume (ppb) in the cabin, with peak concentrations of about 600 ppb (TLV levels of 80--100 ppb apply in most IATA countries). Finally, medical and technical recommendations are made for future measurements.
Flow Cytometric Evaluation of Postmortem Pulp DNA Degradation (2003)

During postmortem autolysis, cellular organelles and nuclear DNA break down into their constituent parts. DNA flow cytometric analysis was applied to study the denaturation of splenic cell DNA as a possible method for postmortem interval determination. DNA denaturation continued for 72 hours at a constant rate, with no intact DNA peaks thereafter. The value of using dental pulp tissue for flow cytometric determination of postmortem interval was investigated. The pulps of 57 routinely removed impacted third molars from patients 15 to 30 years of age were obtained. Pulp tissue was removed at 24, 48, 72, 96, 120, and 144 hours postextraction. Debris (degraded DNA) was defined as all signals left of the standardized mean 2n peak and expressed as a percentage of the total number of signals. In contrast to the splenic cell DNA, dental pulp tissue exhibited minimal DNA degradation by 144 hours postextraction, and no constant relation was found between time and DNA degradation during this time. In this study, pulp tissue was found to be unreliable to determine the early postmortem interval but might be of greater value in the later stages.
La Evaluación Económica de los Proyectos Sociales (1993)

Resalta la dificultad que, para las herramientas tradicionales de análisis, presentan los proyectos sociales; entendiéndose por proyectos sociales aquellos relativos a la salud, educación, seguridad, justicia, nutrición y bienestar de la fam
Pharmacokinetic Strategies for Treatment of Drug Overdose and Addiction (2012)

The pharmacokinetic treatment strategy targets the drug molecule itself, aiming to reduce drug concentration at the site of action, thereby minimizing any pharmacodynamic effect. This approach might be useful in the treatment of acute drug toxicity/overdose and in the long-term treatment of addiction. Phase IIa controlled clinical trials with anticocaine and antinicotine vaccines have shown good tolerability and some efficacy, but Phase IIb and III trials have been disappointing because of the failure to generate adequate antibody titers in most participants. Monoclonal antibodies against cocaine, methamphetamine and phencyclidine have shown promise in animal studies, as has enhancing cocaine metabolism with genetic variants of human butyrylcholinesterase, with a bacterial esterase, and with catalytic monoclonal antibodies. Pharmacokinetic treatments offer potential advantages in terms of patient adherence, absence of medication interactions and benefit for patients who cannot take standard medications.
The Role of T Lymphocytes in Cancer Patients Undergoing Immunotherapy with Autologous Dendritic Cells (2011)

Immunotherapy with DCs stimulated the immune response, as evidenced by an increase in percent fluorescence of most cell populations investigated during the specified treatment period.
School Guidance Focus: A Hong Kong Study (1998)

School guidance focus: a Hong Kong Study As schools worldwide pay more attention to pastoral care and pupil guidance research into guidance focus as a school factor and ways of assessing it are still undeveloped. The study reported here aimed at identifying the guidance focus (remedial, preventive or developmental) adopted in Hong Kong secondary schools. In the absence of previous studies, it was necessary to establish criteria of identification. Constructs of guidance were first identified using Kelly's Repertory Grid. This was followed by a questionnaire survey of guidance practices. The findings indicated that case work and developmental group work were useful indicators. The criteria established for assessing schools' guidance focus were the amount of time spent by the school guidance team and the priority they assigned to each indicator. The findings also revealed conceptual and methodological problems in determining school guidance focus and in categorising schools accordingly, thus opening up other areas of research. While specific to Hong Kong secondary schools, the method is reported for its relevance to other school settings.
[Superoxide dismutase mimetics: possible clinical applications]. (2008)

Superoxide, and its derivatives hydrogen peroxide, hydrogen peroxide, and peroxynitrite, play an important role in aging and in several diseases, including cancer, diabetes, inflammation, neurodegenerative and vascular disorders. Increased level of reactive oxygen species leading to severe organ damage could also be a consequence of applied therapy, such as radiation therapy, chemotherapy,reperfusion after ischemia, or transplantation. A new approach to protect normal tissues without jeopardizing the efficacy of treatment may be to apply specific catalytic antioxidants as adjuncts to the therapy. In this review a number of synthetic low-molecular-weight agents are discussed that may be used as mimetics of superoxide dismutase enzymes (SODm) to treat diseases of various etiologies and to protect healthy tissues during therapy.
A Stepper Micropump for Ferrofluid Driven Microfluidic Systems (2009)

We demonstrate a novel stepper micropump for ferrofluid driven microfluidic systems. The rotor is a ferrofluid plug that works as a piston pushing another liquid in a circular microchannel. The actuation concept is similar to that of a stepper motor, where the angular velocity can be precisely controlled by a series of actuating solenoids. The actuation force is adjusted by the driving voltage or current. Thus fluids with different viscosities can be handled in the pump. The pump can be used for a circular ferrofluid driven microchip for rapid polymerase chain reaction (PCR), where the sample is continuously pumped in a closed loop over three temperature zones to realize thermal cycling. Keywords: Micropump, ferrofluid, electromagnetic actuation, PCR, microfluidics