gebhart/patrepeval huggingface dataset:
Effects of lithium gammalinolenate on the perfusion of liver and pancreatic tissues in pancreatic cancer. (1998)

Because of its poor prognosis, new modalities to treat pancreatic cancer are highly welcome. Gammalinolenate (GLA) has been shown to possess antitumor activity on various human cancer cell lines in vitro and some evidence has been found of its modulative activity on tubulin active agents, such as vinca alkaloids. GLA treatment is thought to change the penetration and distribution of chemotherapeutic agents in pancreatic tumor tissue. The in vivo effects of GLA are widely unknown. This is the first study on the modulation effects of both oral or intravenous GLA on blood perfusion in vivo. We analysed tissue perfusion prior to treatment and on the 10th day of GLA treatment in patients with pancreatic cancer. Dynamic gamma imaging was performed for 20 minutes after Tc-99m-MIBI injection, and the whole body was scanned after the dynamic study and at 4 hours. Half-lives in liver, left kidney, spleen, pancreas and tumor were recorded using a developed macro program for background corrected geometric mean data from irregular region of interests. Half-lives in the liver did not change due to oral GLA treatment, but they decreased dramatically in two of three patients after i.v. GLA treatment. Additionally, individual changes were observed in pancreatic half-lives, as in four out of five cases the half-life increased and in one case it decreased. No major changes were observed in kidney and spleen half-lives. GLA treatment had no effects on the blood brain barrier. This technique demonstrates perfusion in salivary glands, thyroid, lungs, heart, spleen, kidneys, muscles, spine and bladder, but no changes in perfusion could be detected due to GLA treatment. However, qualitatively enhanced blood flow through the pancreatic tumor was observed. In all patients irrespective of the route of administration of GLA, the organ-to-background ratios in liver decreased. The effect is, however, smallest after oral dosing. The pancreas-to-background ratio was increased in 3/5 patients, these patients exhibited stabilized disease. In a patient with large liver metastases the pancreas-to-background ratio decreased, and she showed a rapid disease progression during GLA therapy. The change in the pancreatic uptake was inversely proportional to the change in CA 19-9 concentration. Our results indicate the that GLA treatment dramatically changes tissue perfusion, especially in liver and pancreatic tumors, even at low doses, and these changes may predict response to GLA therapy.
Serrodyne optical frequency translation with high sideband suppression (1988)

A Ti:NiNbO/sub 3/ serrodyne optical frequency shifter with 40-dB overall sideband suppression has been demonstrated. This performance can be achieved using either a laser diode or a broadband superluminescent diode as an optical source. The device utilizes a single-polarization waveguide design and a specialized sawtooth drive circuit.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The aerodynamics of hovering insect flight. I. The quasi-steady analysis (1984)

Abstract The conventional aerodynamic analysis of flapping animal flight invokes the ‘quasisteady assumption’ to reduce a problem in dynamics to a succession of static conditions: it is assumed that the instantaneous forces on a flapping wing are equivalent to those for steady motion at the same instantaneous velocity and angle of attack. The validity of this assumption and the importance of unsteady aerodynamic effects have long been controversial topics. Weis-Fogh tested the assumption for hovering animal flight, where unsteady effects are most pronounced, and concluded that most insects indeed hover according to the principles of quasi-steady aerodynamics. The logical basis for his conclusion is reviewed in this paper, and it is shown that the available evidence remains ambiguous. The aerodynamics of hovering insect flight are re-examined in this series of six papers, and a conclusion opposite to Weis-Fogh’s is tentatively reached. New morphological and kinematic data for a variety of insects are presented in papers II and III, respectively. Paper IV offers an aerodynamic interpretation of the wing kinematics and a discussion on the possible roles of different aerodynamic mechanisms. A generalized vortex theory of hovering flight is derived in paper V, and provides a method of estimating the mean lift, induced power and induced velocity for unsteady as well as quasi-steady flight mechanisms. The new data, aerodynamic mechanisms and vortex theory are all combined in paper VI for an analysis of the lift and power requirements and other mechanical aspects of hovering flight. A large number of symbols are needed for the morphological, kinematic and aerodynamic analyses. Most of them appear in more than one paper of the series, and so a single comprehensive table defining the major symbols from all of the papers is presented at the end of this paper.
Hydrogen sulfide in the endocrine and reproductive systems (2010)

Hydrogen sulfide (H(2)S) is now considered a member of a group of signaling molecules termed 'gasotransmitters'. H(2)S has been shown to be generated in the endocrine and reproductive organs and elicits various actions. H(2)S modulates insulin secretion in pancreatic islets. Adipose tissues have the ability to produce H(2)S, which regulates the local insulin sensitivity and vascular responsiveness. H(2)S also acts on the hypothalamic-pituitary-adrenal axis and is involved in stress responses. The effects of H(2)S on male and female reproductive function have also attracted great interest for their potential therapeutic implications in reproductive disorders. Alterations of H(2)S biosynthesis are associated with various endocrine disorders, and hormones can be important factors in the regulation of H(2)S production. Understanding the regulatory mechanisms for H(2)S synthesis pathways may help develop new therapeutic strategies.
EFFECT OF MITOCHONDRIAL STABILIZERS ON THE IMMUNOGENICITY OF THE PARTICULATE FRACTION ISOLATED FROM<i>MYCOBACTERIUM TUBERCULOSIS</i> (1964)

Youmans, Anne S. (Northwestern University Medical School, Chicago, Ill.), and Guy P. Youmans. Effect of mitochondrial stabilizers on the immunogenicity of the particulate fraction isolated from Mycobacterium tuberculosis. J. Bacteriol. 87:1346-1354. 1964.-A number of substances which have been used to stabilize mammalian mitochondrial preparations were tested to determine whether they would similarly affect the immunogenicity of a particulate fraction prepared from ruptured viable attenuated mycobacterial cells. The use of 0.44 m sucrose and the presence of 3 x 10(-2)m MgCl(2) during the preparatory processes markedly increased the immunogenicity of the particulate fraction. The increase was so great that immunogenic preparations were then consistently obtained which, in adequate dosage, were more immunogenic in CF-1 male mice than were viable attenuated mycobacterial cells. On the other hand, adenosine triphosphate (ATP), citrate, and polyvinylpyrrolidone when present during the preparatory processes reduced the immunogenicity. The addition of MgCl(2), ethylene-diaminetetraacetate, or ATP to the particulate fraction after it had been prepared did not increase its immunogenicity. When the particles were prepared in the 0.44 m sucrose buffer alone, incorporated in Freund's adjuvant, and injected intraperitoneally, immunogenicity was increased. However, this increase was not significantly greater than that obtained when the particles were prepared in the sucrose buffer containing MgCl(2). The immune state engendered in mice by the intraperitoneal injection of the particulate fraction persisted for at least 12 weeks.
A study of the factors contributing to the metal dusting of Fe–Cr–Ni alloys in highly carburising atmospheres (2000)

Metal dusting is a recurring problem within the petrochemical industry that has serious consequences for plant efficiency and reliability, as well as for operational safety. The underlying factors governing its occurrence are not fully understood and therefore studies under closely monitored conditions in atmospheres that simulate those encountered in service are essential.For this preliminary study, candidate reformer and pyrolysis tube materials have been selected and exposed at 560°C for periods of up to 200 hours in a highly reducing atmosphere. The intention has been to focus on some of the main variables that are thought to possibly contribute to metal dusting and evaluate their contribution through a series of controlled experiments. In addition to alloy composition, the principal parameters that have been addressed are surface condition and system pressure.In the series of experiments described in this paper, machined and ground as well as polished specimens have been exposed to an H2–24.4%CO–2.4%H2O gas mixture at pressures of nominally 1.5, 2 and 5 bar (absolute). As a consequence of the character of this gas (i.e. carbon activity, ac, >>1), extensive coke deposition occurs on the metallic specimens. Thus, a thermal cycle has been introduced into the test procedure, generally at 25 hour intervals, so that the samples can be inspected and coke removed.Cross-sectional optical and scanning electron microscope examinations of the morphology of the coke deposit and the nature and extent of attack have provided a deeper understanding of the importance of alloy composition and the contributions made by surface treatment and system pressure.
α,β-amyrin, a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats (2010)

alpha,beta-amyrin has the potential to combat acute pancreatitis by acting as an anti-inflammatory and antioxidant agent.
Ad Moratorium (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Semantic-based partial retrieval of CAD models for design reuse (2009)

In this paper, we present a semantic-based partial retrieval approach of CAD models for design reuse. Based on the observation of reusable regions for design of 3D CAD models, for each model in the model library, we propose an algorithm that automatically extracts its reusable regions for partial retrieval. To further effectively support the partial retrieval of these reusable regions through simple queries, we represent each reusable region by all its local matching regions and describe each local matching region in a hierarchical way. Based on the hierarchical descriptor, a partial retrieval method for reusable regions is put forward. The approach proposed is implemented and tested by hundreds of mechanical parts. Preliminary results show that the method can effectively support partial retrieval for design reuse.
Cyclic Diacyl Peroxides. III.<sup>1</sup> The Reaction of Phthaloyl Peroxide with Olefins (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic Diacyl Peroxides. III.1 The Reaction of Phthaloyl Peroxide with OlefinsFrederick D. Greene and William W. ReesCite this: J. Am. Chem. Soc. 1958, 80, 13, 3432–3437Publication Date (Print):July 1, 1958Publication History Published online1 May 2002Published inissue 1 July 1958https://pubs.acs.org/doi/10.1021/ja01546a058https://doi.org/10.1021/ja01546a058research-articleACS PublicationsRequest reuse permissionsArticle Views322Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Emerging Photoluminescence in Monolayer (2014)

ABSTRACT Novel physical phenomena can emerge in low-dimensional nanomaterials. Bulk MoS2, a prototypical metal dichalcogenide, is an indirect bandgap semiconductor with negligible photoluminescence. When the MoS2 crystal is thinned to monolayer, however, a strong photoluminescence emerges, indicating an indirect to direct bandgap transition in this d-electron system. This observation shows that quantum confinement in layered d-electron materials like MoS2 provides new opportunities for engineering the electronic structure of matter at the nanoscale.
The Large-Scale Production and Use of a Single-Cell Oil Highly Enriched in Docosahexaenoic Acid (2001)

Docosahexaenoic acid (DHA), is the primary structural fatty acid in the membranes of neurological tissues and deficienciesof DHA have been correlated with chronic neurological disorders including attention deficit disorder, depression, and senile dementia. Although DHA can be obtained from fish and certain animal organ meats, the primary producers of DHA in the biosphere are the phytoplankton in the sea. We have optimized the growth under heterotrophic conditions of a specific marine algal species to produce a triacylglycerol oil enriched to over 40% with DHA. The scale-up of this process presented many unique problems both in the fermentation of the microalgae, and in the subsequent processing of the oil. Commercial quantities of the DHA-rich oil are now being produced under GMP (Good Manufacturing Practice) conditions at full scale for use in food products ranging from infant formula to nutritional supplements. Double blind clinical intervention trials have demonstrated several unique characteristics of this oil which differentiate the microalgal oil from fish oil. These are consequences of the simplicity of the fatty acid profile, the remarkable stability of the oil, the purity and consistency of this oil, and the exceptionally high level of DHA enrichment.
Using adaptive interfaces to improve mobile map-based visualisation (2008)

Visualising map-based data on mobile devices presents many challenges. Small displays, comparatively slow hardware and awkward interaction techniques all combine to make mobile map-based visualisations difficult to design and often frustrating to use. Existing mobile visualisation techniques do not adequately address these problems. Adaptive user interfaces, which adapt to the individual characteristics of the user, are proposed as an alternative approach to improve mobile map-based visualisation (MMV) systems. A model is presented which incorporates an adaptive user interface into the design of MMV systems. A prototype MMV system, called MediaMaps, is then described, demonstrating the successful implementation of this model. The results of an evaluation of MediaMaps are then presented, showing its effectiveness in supporting user needs and requirements for MMV using an adaptive user interface.
Novel current-conveyor-based single-resistance-controlled/voltage-controlledoscillator employing grounded resistors and capacitors (1994)

A novel single-resistance-controlled/voltagecontrolled oscillator using three current conveyors, two grounded capacitors and three grounded resistors is presented. The proposed circuit offers the following advantageous features: employment of three grounded resistors for ease of adjustment, independent oscillation control through a single grounded resistor, independent frequency control through a single grounded resistor, employment of two grounded capacitors ideal for integration, ease of convertibility into a voltage-controlled oscillator, and very good frequency stability.
A placebo‐controlled, randomized, double‐masked, variable dosage, clinical trial of azathioprine with and without methylprednisolone in multiple sclerosis (1989)

Ninety-eight patients with multiple sclerosis (MS) in the chronic progression phase entered a 3-year clinical trial to determine if azathioprine (AZ) alone or with adrenal cortical steroids stabilizes the course of MS. In group AM, the patients took AZ throughout and methylprednisolone (MP) for the first 36 weeks. Group AP received AZ and placebo instead of MP. Group PP took placebos for both drugs. We adjusted the AZ to maintain the total white blood cell count within 3,000 to 4,000/mm3; we gave the MP in a fixed dose "pulse" and alternate-day regimen. The "intent-to-treat" groups had no statistically significant differences in the rates of progression among the 3 treatments. Subgroup analysis suggests that patients in the AM group who completed treatment exactly according to protocol did statistically significantly better than the placebo recipients using the sum of Standard Neurological Examination scores, slightly better using the quantitative neuro-performance tests, but no better using Mickey's Illness Severity Scores or Kurtzke's Disability Status Scale. Also, the AZ-treated groups had half the relapse rate of the placebo-treated group. Adverse reactions to AZ accounted for most withdrawals. Hematologic and hepatic abnormalities were significantly associated with AZ, but serious non-MS abnormalities were uncommon and were equally distributed among the 3 groups. Addition of MP to the AZ slightly improved the efficacy of the treatment, but also increased the adverse effects. The benefits of AZ with or without steroids did not outweigh the risks, and therefore we do not recommend this treatment for patients with chronic progressive MS.
Short‐term response of brain tissue to cerebrospinal fluid shunts<i>in vivo</i>and<i>in vitro</i> (1992)

The purpose of the studies was to determine how gross physical characteristics of cerebrospinal fluid (CSF) shunts and the cellular proliferative response to shunts contribute to shunt obstruction. Ventricular catheters with round holes, slots, and flanges were implanted into the lateral ventricles of rabbits for 4 weeks. All shunt designs were subject to ingrowth of tissue from the ventricle wall or choroid plexus. There were no qualitative or quantitative differences between normal and hydrocephalic rabbits. Astroglial cells from newborn mice were cultured on shunt catheters for 2 or 4 weeks. The growth of these cells was poor, probably because the cells cannot attach well to the silicone rubber substrate. Contact between the shunt catheter and vascularized brain tissue is the most important factor in the genesis of shunt obstruction.
Cell Adhesion and Proliferation onto Chitosan-based Membranes Treated by Plasma Surface Modification (2010)

Surface properties play a vital role in the functioning of a biomaterial. Cellular adherence and growth onto biomaterials can be enhanced in biomaterial modifications of their surface. In this work, the cell behavior on chitosan membranes modified by argon and nitrogen-plasma treatments was investigated. Characterization of the membranes was performed using atomic force microscopy, contact angle measurements, and X-ray photoelectron spectroscopy. Cytotoxicity assessment and direct contact assay were carried out for untreated and treated chitosan membranes using L929 fibroblast-like cells. Cell morphology and cell viability were assessed to evaluate the cell attachment and proliferation. Changes in terms of roughness, surface chemistry, and hydrophilicity/hydrophobic balance of chitosan-modified membranes were observed. Regarding cell studies, the findings revealed that the extracts of all membranes do not induce cytotoxic effects. Moreover, the in vitro assays evidenced an improvement of the L929 adhesion and attachment when compared to untreated chitosan membranes. Overall, the data obtained clearly demonstrated that plasma treatments constitute an effective way of improving the biocompatibility of chitosan membranes towards to their use in biomedical applications.
Entwicklung einer Methodik zur Modularisierung von Druckgusswerkzeugen (2015)

The Cluster of Excellence "Integrative Production Technology for High-Wage Countries" at the RWTH Aachen University, promoted and financed by the German Research Foundation (DFG) is pursuing the long-term goal of increasing the com-petitiveness of German production technology. Focus is on the development of cross-solutions for complicated tasks with an integrative approach.A major goal for production processes of the future is to create a synthesis of mass and individual production. The motivation behind this work lies in the reduction of production costs with a simultaneous increase of the current product range. For high pressure die casting in general, there is a one-to-one correlation between the die and casting. The time-consuming and costly design and manufacturing of die casting dies will be simplified, enabling rapid implementation of product variants.To achieve this, the methodology is composed of a sequence of three phases. During these phases, the focus is narrowed down from company perspective to die perspective, and finally, to die component perspective. By consecutively proceeding through the phases, one identifies the stage of the production process where modularisation is most beneficial, and categorises die components with respect to their modularisation potential. The final phase determines how a chosen component is turned into a module. This includes determining how many different variations of each module property are needed to be able to cover the desired product portfolio by simultaneously lowering the overall costs.The methodology provides a systematic approach for designing modular dies with which even individual customer requirements can be met.