gebhart/patrepeval huggingface dataset:
Correction of environmental magnetic fields for the acquisition of Nuclear magnetic relaxation dispersion profiles below Earth’s field (2017)

T<sub>1</sub> relaxation times can be measured at a range of magnetic field strengths by Fast Field-Cycling (FFC) NMR relaxometry to provide T<sub>1</sub>-dispersion curves. These are valuable tools for the investigation of material properties as they provide information about molecular dynamics non-invasively. However, accessing information at fields below 230 μT (10kHz proton Larmor frequency) requires careful correction of unwanted environmental magnetic fields. In this work a novel method is proposed that compensates for the environmental fields on a FFC-NMR relaxometer and extends the acquisition of Nuclear Magnetic Relaxation Dispersion profiles to 2.3μT (extremely low field region), with direct application in the study of slow molecular motions. Our method is an improvement of an existing technique, reported by Anoardo and Ferrante in 2003, which exploits the non-adiabatic behaviour of the magnetisation in rapidly-varying magnetic fields and makes use of the oscillation of the signal amplitude to estimate the field strength. This increases the accuracy in measuring the environmental fields and allows predicting the optimal correction values by applying simple equations to fit the data acquired. Validation of the method is performed by comparisons with well-known dispersion curves obtained from polymers and benzene.
Dendritic Cells and Macrophages Are Productively Infected by Poliovirus (2004)

Expression of the poliovirus receptor (PVR) on cells is a major host determinant of infection by poliovirus. Previously, the only immune cell type known to express PVR was the blood-derived monocyte, which is susceptible to infection at very low frequency. We demonstrate that professional antigen-presenting cells-macrophages and dendritic cells, generated upon differentiation of monocytes-retain expression of PVR and are highly susceptible to infection by type 1 Mahoney strain of poliovirus. Maximal cell-associated titers of virus are obtained within 6 to 8 h postinfection, and cell death and lysis occurs within 24 h postinfection. Similar kinetics are observed in cells infected with the Sabin 1 vaccine strain. Although protein synthesis and receptor-mediated endocytosis are inhibited upon poliovirus infection of these critical antigen-presenting cells, we demonstrate for the first time that functional presentation of antigen occurs in these infected cells via the HLA class II pathway.
A new method for instantaneous reactive power compensation in three-phase four-wire systems (2004)

This paper proposes a novel method to generate the current reference for a parallel active power filter that does not need energy storage elements. The method compensates for the reactive power and eliminates the neutral current in unbalanced three-phase four-wire systems (sinusoidal or nonsinusoidal) with or without zero-sequence components in the currents and /or voltages. In contrast with existing methods, no coordinate transformation is used, assuring a simple controller design and implementation. Simulation and experimental results are provided to validate the proposed method.
Steady-state analysis of a semi-blind adaptive beamforming algorithm for TDMA signals (2008)

We describe an adaptive beamforming algorithm for time- division multiple-access (TDMA) signals that utilizes a modified least-squares (LS) cost function, and analyze its performance using a stochastic model. The beamformer weights are computed via a two-step procedure: initial weights are calculated from the training sequence, and these are refined by a semi-blind algorithm using the modified LS cost function. The main goal of the paper is to analyze this algorithm using a stochastic model and Wiener filter theory for the case when the look-direction vector is mismatched. The performance of the proposed adaptive beamformer is also evaluated using simulated TDMA data.
In vivo antisense activity of ENA(R) oligonucleotides targeting PTP1B mRNA in comparison of that of 2'-MOE-modified oligonucleotides (2007)

The 2'-0-(2-methoxy)ethyl (2'-MOE)-modified gapmer antisense oligonucleotide ISIS113715, which targets protein-tyrosine phosphatase IB (PTP1B) mRNA, increases insulin sensitivity and normalizes plasma glucose levels in diabetic ob/ob and db/db mice. In the present study, the efficacy of the isosequential 2'-O,4'-C-ethylene-bridged nucleic acid (ENA)-modified oligonucleotide ENA-1 was compared with that of ISIS113715 in order to further improve the down-regulation of PTP1B in db/db mice. Intraperitoneal administration of ENA-1 more effectively decreased the plasma glucose levels in db/db mice than ISIS113715. Moreover, ENA-1 decreased the expression of PTP1B in the liver and fat of db/db mice more effectively than ISIS113715. These data indicate that ENA modifications enhance the ability of antisense oligonucleotides and make them superior to second-generation 2'-MOE modifications. We would like to thank to Drs. Shinya Tsutsumi and Kenji Kawai for the Tm measurement and autoradiography experiments. ENA is a registered trademark of Mitsubishi-Kagaku Foods Corporation.
ChemInform Abstract: SYNTH. VON STREPTOZOTOCIN‐DERIVATEN (1970)

Abstract Die aus den N‐Benzyloxycarbonyl‐β‐D‐ bzw. α‐D‐glucosaminiden (I) nach Neuberger und Rivers erhältlichen Methylglucosaminidhydrochloride (II) (Ausbeute 15,2 bzw. 79%) geben mit Methylisocyanat die Harnstoff‐Derivate (III) (etwa 65%) und durch anschließendes Nitrosieren die Nitrosoverbindungen (IV) (50 bzw. 70%).
Vaporization of zinc from scrap (1996)

The rate of zinc vaporization from galvanized scrap was measured using a thermogravimetric apparatus along with chemical analysis. It is found that the rate of zinc vaporization is very fast in nitrogen and carbon monoxide atmospheres at temperatures higher than 950 C. At lower temperature rate decreases with decreasing temperature and is controlled by the gas phase mass transport. The simultaneous oxidation and vaporization of zinc occurs when the samples were heated in carbon dioxide and air. The current experimental results indicate that almost all of the zinc from scrap vaporizes during the heating process in a very short period of time after the temperature reaches above 850 C.
Emissivity independent heating of 3D patterns (2007)

It has been shown that for radiative heating systems, 3D patterns have a strong influence on local wafer temperatures during anneal. Since the temperature gradients on the wafer increase with increasing heat up rates and aspect ratios, the importance of these effects is expected to grow when changing to future technology nodes. For conductive heating systems the effect of the 3D patterns is negligible.
Differential acute impact of therapeutically effective and overdose concentrations of lithium on human neuronal single cell and network function (2021)

Lithium salts are used as mood-balancing medication prescribed to patients suffering from neuropsychiatric disorders, such as bipolar disorder and major depressive disorder. Lithium salts cross the blood-brain barrier and reach the brain parenchyma within few hours after oral application, however, how lithium influences directly human neuronal function is unknown. We applied patch-clamp and microelectrode array technology on human induced pluripotent stem cell (iPSC)-derived cortical neurons acutely exposed to therapeutic (<1 mM) and overdose concentrations (>1 mM) of lithium chloride (LiCl) to assess how therapeutically effective and overdose concentrations of LiCl directly influence human neuronal electrophysiological function at the synapse, single-cell, and neuronal network level. We describe that human iPSC-cortical neurons exposed to lithium showed an increased neuronal activity under all tested concentrations. Furthermore, we reveal a lithium-induced, concentration-dependent, transition of regular synchronous neuronal network activity using therapeutically effective concentration (<1 mM LiCl) to epileptiform-like neuronal discharges using overdose concentration (>1 mM LiCl). The overdose concentration lithium-induced epileptiform-like activity was similar to the epileptiform-like activity caused by the GABA<sub>A</sub>-receptor antagonist. Patch-clamp recordings reveal that lithium reduces action potential threshold at all concentrations, however, only overdose concentration causes increased frequency of spontaneous AMPA-receptor mediated transmission. By applying the AMPA-receptor antagonist and anti-epileptic drug Perampanel, we demonstrate that Perampanel suppresses lithium-induced epileptiform-like activity in human cortical neurons. We provide insights in how therapeutically effective and overdose concentration of lithium directly influences human neuronal function at synapse, a single neuron, and neuronal network levels. Furthermore, we provide evidence that Perampanel suppresses pathological neuronal discharges caused by overdose concentrations of lithium in human neurons.
Notice of Removal: FPGA Logic Block to Implement Resource-Efficient Multiplexers (2010)

Removed.
Parathyroid Hormone Responses to Calcium Stress during Eggshell Calcification<sup>*</sup> (1984)

PTH bioactivity during the egg-laying cycle of the chicken has been measured by the cytochemical bioassay for PTH. During the period of eggshell calcification, PTH bioactivity is elevated. After completion of the shell the plasma PTH falls to a low level but is slightly raised again 2 h after ovulation. These results indicate that changes in bioactive PTH play an important role in the calcium metabolism of the chicken during this physiological calcium stress.
Radical fluorination powered expedient synthesis of 3-fluorobicyclo[1.1.1]pentan-1-amine (2015)

Exploration of novel chemical space, a modern trend in medicinal chemistry, is heavily reliant on synthetic access to new and interesting building blocks. In this direction, the following work describes an expedient synthesis of one such moiety, 3-fluorobicyclo[1.1.1]pentan-1-amine, by employing radical fluorination.
Computer guidance system for single-incision bimanual robotic surgery (2012)

The evolution of surgical robotics is following the progress of developments in Minimally Invasive Surgery (MIS), which is moving towards Single-Incision Laparoscopic Surgery (SILS) procedures. The complexity of these techniques has favored the introduction of robotic surgical systems. New bimanual robots, which are completely inserted into the patient's body, have been proposed in order to enhance the surgical gesture in SILS procedures. However, the limited laparoscopic view and the focus on the end-effectors, together with the use of complex robotic devices inside the patient's abdomen, may lead to unexpected collisions, e.g., between the surrounding anatomical organs not involved in the intervention and the surgical robot. This paper describes a computer guidance system, based on patient-specific data, designed to provide intraoperative navigation and assistance in SILS robotic interventions. The navigator has been tested in simulations of some of the surgical tasks involved in a cholecystectomy, using a synthetic anthropomorphic mannequin. The results demonstrate the usability and efficacy of the navigation system, underlining the importance of avoiding unwanted collisions between the robot arms and critical organs. The proposed computer guidance software is able to integrate any bimanual surgical robot design.
Design of guided-mode resonance mirrors for short laser cavities (2015)

A guided-mode resonance mirror (GMRM) consists of a waveguide grating integrated on an optical buffer layer on a high-reflection substrate. An incident free-space wave at the resonance wavelength is once coupled by the grating to a guided mode and coupled again by the same grating back to free space. The reflection characteristics of a GMRM are numerically calculated and theoretically analyzed. It is predicted that notch filtering or flat reflection spectra are obtained depending on the optical buffer layer thickness. Design of short cavities using a GMRM is discussed for potential application in surface-mount packaging of diode lasers onto a photonic circuit board.
Réactivité du bromure de 5-thioxylopyranosyle et du 1,5-dithioxylopyranoside vis-à-vis d’anions thiolate (2003)

La réaction de différents anions thiolate électrogénérés 1′ (NC–C 6 H 4 –CO–C 6 H 4 –S – ), 2′ (C 6 H 5 –S – ), 3′ (p–CH 3 –C 6 H 4 –S – ), 4′ (C 6 H 5 –CH 2 –S – ) et 5′ (CH 3 –S – ) vis-à-vis du bromure de 5-thioxylopyranosyle Xyl–Br 6 (bromure de 2,3,4-tri- O -acetyl-5-thio-α-D-xylopyranosyle) a été étudiée. Si aucune réaction n’a lieu entre 1′ et 6 , on obtient, au départ des anions 2′ et 3′ , les 1,5-dithioxylopyranosides correspondants, Xyl–SR ( 7 R = C 6 H 5 – et 8 R = p -CH 3 –C 6 H 4 ). La réaction effectuée en présence de 4′ ou de 5′ conduit au 5–thiopyranose 9 et aux disulfures correspondants 4 (C 6 H 5 –CH 2 –S) 2 et 5 (CH 3 –S) 2 . L’anion 5′ réagit avec le 1,5-dithioxylopyranoside 10 Xyl–SR′ (R′ = –C 6 H 4 – CO–C 6 H 4 –CN), avec formation du sulfure dissymétrique 11 (CH 3 –S–C 6 H 4 –CO–C 6 H 4 –CN) et du 1,5-dithioxylose 12 . Le même type de réaction est observé au départ de 4′ et le sulfure 13 (C 6 H 5 –CH 2 –S–C 6 H 4 –CO–C 6 H 4 –CN) est obtenu avec un rendement élevé (95 %). Ces différences de réactivité s’expliquent essentiellement par le caractère nucléophile plus ou moins marqué des anions thiolate.
Partial cloning of a squid microtubule‐associated protein (MAP H1) and the identification of the microtubule binding domain (1993)

An approximately 420-kDa ATP binding protein, referred to as MAP H1, has previously been shown to be involved in microtubule-dependent vesicle motility in the squid giant axon. To gain further insight into the structure and function of this protein, partially overlapping cDNA clones encoding approximately a quarter of the MAP H1 molecule were identified from two squid optic lobe libraries using affinity-purified antibodies to squid MAP H1. One clone in particular (KS18), which hybridizes to an approximately 13-kb message, encodes a series of almost identical repeats of a 16-amino-acid sequence that is tandemly repeated. The sequence of clone KS18 is unique and does not correspond to any nucleotide or amino acid sequence in the data base. The presence of repeated elements within the microtubule binding domain of several other MAPs prompted us to investigate whether the MAP H1 repeats are involved in microtubule binding. In-vitro-synthesized polypeptides containing these repeats sediment with taxol-stabilized microtubules in a microtubule binding assay. The predicted secondary structure of the 16-amino-acid repeat region of MAP H1 contains alternating beta-sheets and turns and could form the globular domain seen in negative-stain electron micrographs of MAP H1.
Receiver mobility influence on OCDMA indoor wireless communications system performances (2010)

In this paper we present a study of the receiver movement influence on the indoor wireless communication system performances. We consider an optical code division multiple access (OCDMA) indoor wireless communication system with spectral encoding and evaluate its performances in cases of classical OCDMA and dynamic OCDMA. As the receiver moves increasingly away from transmitter the amount of power received in that place will be getting smaller and system performances are affected. Knowledge of the impulse response in different positions in the room allows calculation of the amount by which power is lower at that point. We showed that increasing the power received in that place with the necessary amount, system performance are maintained at the same values, even if the receiver is moving away from transmitter.
Use of Multiple Fractal Dimensions to Quantify Airborne Particle Shape (1994)

Fractal dimension has been considered as a quite useful index for quantifying irregular or self-similar shapes. However, shapes of airborne particles may not be fully self-similar and may not be well characterized by a single fractal dimension. Alternatively, they may this study. The results are compared with the result of single fractal dimension. be self-similar at different levels of scale and therefore, may be well represented by multiple fractal dimensions. Three typical kinds of airborne particle shapes were characterized by the multiple fractal dimension in
Highly efficient hollow fiber compression scheme for generating multi-mJ, carrier-envelope phase stable, sub-5fs pulses (2011)

We present a simple technique for increasing the throughput of static hollow fiber compressors by up to 60%. By seeding the fiber with positively chirped, circularly polarized pulses, we obtain CEP-stable, 1.6mJ, sub-5fs pulses.
Feed Composition for Sodium-Bearing Waste Treatment Process, Rev. 3 (2003)

Treatment of sodium-bearing waste (SBW) at the Idaho Nuclear Technology and Engineering Center (INTEC) within the Idaho National Engineering and Environmental Laboratory is mandated by a Settlement Agreement between the Department of Energy and the State of Idaho. One of the requirements of the Settlement Agreement is to complete treatment of SBW by December 31, 2012. To support both design and development studies for the SBW treatment process, detailed feed compositions are needed. This report contains the expected compositions of these feed streams and the sources and methods used in obtaining these compositions.
Control of Time-Varying Epidemic-Like Stochastic Processes and Their Mean-Field Limits (2017)

The optimal control of epidemic-like stochastic processes is important both historically and for emerging applications today, where it can be especially important to include time-varying parameters that impact viral epidemic-like propagation. We connect the control of such stochastic processes with time-varying behavior to the stochastic shortest path problem and obtain solutions for various cost functions. Then, under a mean-field scaling, this general class of stochastic processes is shown to converge to a corresponding dynamical system. We analogously establish that the optimal control of this class of processes converges to the optimal control of the limiting dynamical system. Consequently, we study the optimal control of the dynamical system where the comparison of both controlled systems renders various important mathematical properties of interest.
Learning to estimate user interest utilizing the variational Bayes estimator (2005)

Many studies of man-machine interaction using eye trackers have been tackled over recent decades. In this paper, we present a new learning system to estimate user interest with gaze sensory information. In short, a statistical learning scheme, especially the variational Bayes (VB), is incorporated for building probabilistic model parameters, dealing with the uncertainty of estimated user interest. Several computational results show how the VB can cope with user interest estimation, by selectively modeling their uncertainty.
The Female Brindled Mouse as a Model of Menkes' Disease: The Relationship of Fur Pattern to Behavioral and Neurochemical Abnormalities (1991)

The brindled mottled mutant mouse, a model of Menkes' disease, has alterations in copper homeostasis which cause, among other sequelae, neuronal degeneration in selected areas of brain. This work examined the neurochemical changes at postnatal days (PND) 15, 30 and 60 in females heterozygous for the sex-linked brindled mutation. These data were compared to behavioral alterations and to fur coat color at these same time points. The brindled heterozygotic females had lower concentrations of norepinephrine (NE) in the cingulate cortex, and higher levels of dopamine or dopamine metabolites in the cingulate cortex, thalamus and hypothalamus across all ages, although the difference was greatest at PND 15. The brindled females were much less active than their normal littermates at PND 15, but the differences were no longer evident at PND 30 and 60. Mottling of the fur is believed to result from low tyrosinase activity caused by abnormalities in copper metabolism. The fur pattern and behavior of the brindled mice were highly correlated with NE levels in the cingulate cortex and thalamus. These data show that female brindled mice have neurochemical abnormalities similar to (if less severe than) the male hemizygotes, that these abnormalities are regionally specific, are most apparent prior to 30 days of age, and are linked to behavioral deficits. These data also show that the extent of such deficits can be predicted by a quantitative analysis of the fur pattern of these females.
Electron paramagnetic resonance study of iodine-induced radicals of benzo[a]pyrene and other polycyclic hydrocarbons (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron paramagnetic resonance study of iodine-induced radicals of benzo[a]pyrene and other polycyclic hydrocarbonsWilliam Caspary, Bert Cohen, Stephen Lesko, and P. O. P. Ts'oCite this: Biochemistry 1973, 12, 14, 2649–2656Publication Date (Print):July 3, 1973Publication History Published online1 May 2002Published inissue 3 July 1973https://pubs.acs.org/doi/10.1021/bi00738a016https://doi.org/10.1021/bi00738a016research-articleACS PublicationsRequest reuse permissionsArticle Views114Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An ATP-Binding Peptide (1973)

It is generally accepted today that the hydrolysis of ATP, mediated by the contractile protein actomyosin, is the direct source of energy for muscle contraction. Recently, we reported in collaboration with Dr. Michael Bárány (G. Barany et al., 1972), a differential labeling of the ATPase site of frog actomyosin with N-ethylmaleimide (NEM). Since the ATPase and actin-binding sites of myosin overlap (M. Bárány and K. Bárány, 1959), actin exerts a specific protective effect on the ATPase site of myosin. Thus it was possible to titrate frog actomyosin with as many as 15 moles nonradioactive NEM/500,000 daltons protein before the first drop in ATPase activity could be detected. Excess reagent was quenched with cysteine and removed by several reprecipitations of the actomyosin. The ATPase site was then "opened up" by the substrate MgATP, at a concentration of 2 mm. A 5-fold molar excess of [14C]NEM was added, resulting in abolition of...
La réception des Religions orientales de Fr. Cumont : l’apport des comptes rendus (2007)

L’ouvrage de Fr. Cumont, Les Religions orientales, connaît un très vif succès dès sa parution. Cet article étudie la réception de ce « best-seller », maintes fois traduit et réédité, par le biais de la centaine de comptes rendus qui lui ont été consacrés. Si elles sont pour la plupart descriptives et élogieuses, certaines de ces recensions témoignent des débats que suscitent, en pleine crise moderniste, les idées de l’auteur en matière de rapports religions orientales-christianisme et des divergences marquées d’opinion entre les savants catholiques et les autres. Plus rares sont les critiques portant sur la méthode déployée par Cumont ou sur son appréciation des causes du succès des religions orientales, de la nature de la religion romaine ou de l’Orient.