gebhart/patrepeval huggingface dataset:
Studies on the removal of anti‐pig xenoantibodies in the human by plasmapheresis/immunoadsorption (1995)

Abstract: Removal of human preformed natural anti‐pig antibodies from the blood is a prerequisite before xenografting between pig and man can be performed. This work explores the effect of plasmapheresis and immunoadsorption (protein‐A sepharose) on the reduction and recurrence of anti‐pig antibodies in 14 patients. The anti‐pig antibody changes were evaluated by lymphocy to toxic, hemagglutinating, and endothelial cell ELISA techniques. The changes induced showed a similar pattern with all three techniques used. In addition, plasma from plasmapheresis treatments were perfused through pig kidneys and the reduction of anti‐pig antibodies was estimated by the mentioned in vitro techniques. The anti‐pig antibody titers could be reduced to low levels, but not completely eliminated, by 3–4 plasmapheresis sessions. The titers gradually returned to pretreatment levels or higher in a period of 1–2 weeks. A few patients showed signs of a more rapid resynthesis reaching pretransplant levels in 3–4 days. Protein A immunoadsorption satisfactory removed IgG but not IgM antibodies. In vitro perfusion of pig kidneys at 37°C showed a rapid reduction of anti‐pig antibody titers of 3–4 titer steps. The combination of 3–4 plasma exchanges followed by in vitro pig kidney perfusion completely removed all anti‐pig antibodies. Reduction of the anti‐pig lymphocyte and erythrocyte antibody titers by soluble oligosaccharides carrying terminal Galoc‐epitopes was only partly successful. A 40–60% inhibition was achieved by 5–10 mg saccharide/ml serum and no clear inhibition difference between di‐ and trisaccharides was found. Inhibition of plasma obtained after 3–4 plasmapheresis treatments with soluble Galα1‐di‐ and trisaccharides resulted in very low anti‐pig titers. Therefore one feasible pretreatment procedure, before pig to human xenotransplantation could be plasmapheresis for major reduction of anti‐pig antibody titer followed by neutralisation of the remaining antibodies by addition of soluble oligosaccharides or immunoadsorption with Galα‐1‐columns.
Aspect Oriented Pluggable Support for Parallel Computing * (2006)

Abstract. In this paper, we present an approach to develop parallel applications based on aspect oriented programming. We propose a collection of aspects to implement group communication mechanisms on parallel applications. In our approach, parallelisation code is developed by composing the collection into the application core functionality. The approach requires fewer changes to sequential applications to parallelise the core functionality than current alternatives and yields more modular code. We present the collection and show how the aspects can be used to develop efficient parallel applications. 1
Organopalladium(<scp>IV</scp>) chemistry: oxidative addition of organohalides to dimethylpalladium(<scp>II</scp>) complexes to form ethyl, σ-benzyl, and σ-allylpalladium(<scp>IV</scp>) complexes (1988)

The first examples of ethyl, σ-benzyl, and σ-allylpalladium(IV) complexes are formed on oxidative addition of organohalides to PdMe2{(pyridin-2-yl)bis(N-methylimidazol-2-yl)methane}[PdMe2{(py)(mim)2CH}]; the complexes [fac-PdRMe2{(py)(mim)2CH-N,N′,N′}]X (RX = Etl, PhCH2Br, CH2CHCH2Br) are stable at ambient temperature, with the cations present as two isomers, and benzyl bromide also forms the neutral complex fac-Pd(CH2Ph)Me2(bipy)Br on oxidative addition to PdMe2(2,2′-bipyridyl), but Etl and CH2CHCH2Br form transient PdIV species, detectable by 1H n.m.r. spectroscopy, prior to reductive elimination reactions.
Computer-aided design for VLSI (2002)

New CAD issues related to MOS VLSI and optoelectronic integration technologies are reviewed. Especially, new issues on performance and timing driven physical layout, design for VLSI manufacturability and reliability using time-efficient simulation technologies are discussed. In contrast, CAD issues in optoelectronics are presently at the device modeling and circuit simulation level. CAD environments that support fast turnaround model development and circuit verification are discussed with specific optical device models of semiconductor lasers, photodetectors and optical logic gates.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Generation of a BAC-based physical map of the melon genome (2010)

Here we report the construction of the first physical map of a Cucurbitaceae species described so far. The physical map was integrated with the genetic map so that a number of physical contigs, representing 12% of the melon genome, could be anchored to known genetic positions. The data presented is already helping to improve the quality of the melon genomic sequence available as a result of a project currently being carried out in Spain, adopting a whole genome shotgun approach based on 454 sequencing data.
XHive: Efficient Cooperative Caching for Virtual Machines (2010)

Since a virtual machine independently uses its own caching policy, redundant disk operations exacerbate the I/O virtualization overhead when virtual machines access large amounts of data on shared storage. This paper presents XHive, an efficient cooperative caching system that is implemented at the virtualization layer, for consolidated environments. Our proposed scheme globally manages buffer caches of consolidated virtual machines in order to accommodate a shared working set in machine memory. A singlet, which is a block cached solely by a virtual machine, is preferentially given more chances to be cached in machine memory by XHive, when it is evicted by a guest operating system. For efficient use of limited memory, singlets are cached in memory that is collaboratively donated from idle memory of virtual machines. Our evaluation shows that XHive significantly reduces disk I/O operations for shared working sets, thereby achieving high read performance and scalability. Improved scalability enables a high degree of workload consolidation with respect to virtual machines that have shared working sets.
An experimental procedure to derive reliable IBIS models (2002)

One of the greater parts of PCB research and development is to manage the electromagnetic compatibility and signal integrity (EMC/SI) constraints. However, the performances of these EMC/SI tools are based on the quality of used library models: PCB interconnections and IBIS models (I/O buffer information specification). To obtain an IBIS model, three methods are possible: the component maker using the Web, SPICE conversion if the corresponding SPICE model is available, and measurements. This paper describes an experimental procedure that allows creation of reliable IBIS model version 2.1 from measurements. This procedure allows building of models using classical measurement devices, controlling all steps of the procedure and achieving the required model accuracy with regard to its application field. To check the accuracy of the developed procedure, the paper presents the characterization of a TQFP component. Through a classical SI phenomenon (reflection), comparison between measured and simulated results is performed, using the available IBIS Web model and the measured IBIS model.
[Digestive and hemorrhage complications of low-dose aspirin]. (2003)

The GI risk exists, starting with the lowest doses and appears to be dose-dependent. The lesional complications consist mainly of erosive lesions, most often gastric, and rarely true ulcers. Cases of bleeding appear more frequent, but generally are minor. This risk should be taken into account by the prescribing physician and the patient should be informed when treatment with low-dose aspirin is initiated.
Postscript (1955)

Postscript P. Wiles P. Wiles New College, Oxford Search for other works by this author on: Oxford Academic Google Scholar The Economic Journal, Volume 65, Issue 258, 1 June 1955, Pages 351–352, https://doi.org/10.2307/2227924 Published: 01 June 1955
Political Religion: a Concept and its Limitations (2007)

Abstract This article presents political religion as a concept for studying Communism, Fascism and National Socialism, which display significant elements of traditional religion, such as rites of purgation, penitence and renewal, cultic patterns of behaviour, and heresy. It then considers the history of the concept, paying particular attention to the light thrown on the phenomenon by the analysis of Nazism offered by the writer Franz Werfel in 1932. This argued that the roots of its appeal lay in the solution it seemed to offer to the contemporary socio‐political crisis of Weimar, which was widely experienced as a personal crisis of meaning and identity. For believers this imparted a redemptive, religious aura to the entire Nazi movement. Finally, it questions the legitimacy of ‘political religion’ as a concept, asking whether it can truly be used to explain or illuminate political phenomena without distorting the basic idea of religion in the process.
A process for a high yield of aromatics from the oxygen-free conversion of methane: combining plasma with Ni/HZSM-5 catalysts (2007)

A process for a high yield of aromatics and co-produced hydrogen from the oxygen-free conversion of methane using a two-stage plasma-followed-by-catalyst (PFC) reactor at atmospheric pressure and low temperature is reported. Pure methane and a methane and hydrogen mixture as the feed gas for the two-stage PFC process were investigated, respectively. Using the methane and hydrogen mixture as the feed gas into the two-stage PFC reactor, Ni/HZSM-5 catalysts keep stable catalytic activity for a much longer on-stream time than that using pure methane as the feed gas. The maximum aromatic yield may be achieved using low Ni-loading Ni/HZSM-5 catalysts and at a suitable catalyst temperature.
Control Of Globin Gene Transcription (1990)

Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary ...Read More
Antidepressant Profile of Bupropion and three Metabolites in Mice (1990)

Bupropion is a novel antidepressant, distinct from tricyclic antidepressants both neurochemically and behaviorally. Bupropion forms several metabolites in both rodents and humans. Three chemically different molecules - BW 306, BW 494, and BW 287 - were selected. Comparative assessment of antidepressant activity of bupropion and its metabolites in mice, and pharmacological analysis of possible mechanisms of action of the parent drug and its metabolites (using interaction studies with pimozide, D,L-propranolol, and prazosin) were carried out. The results obtained show that: bupropion has a pharmacological spectrum in various animal models which predicts both antidepressant and stimulatory activity in man. BW 306 is the most active of the metabolites studied and, compared to bupropion, seems more "antidepressant" and less stimulant. BW 494, compared to bupropion or BW 306, has a lower degree of activity in various tests used to evaluate antidepressants. BW 287 has no effect in any of the tests used in this study. The interaction studies with pimozide, D,L-propranolol, and prazosin in the various tests have shown that: the stimulatory effect of bupropion, BW 306, and BW 494 is antagonized by both pimozide and prazosin. in the behavioral despair test, the reduction in the duration of immobility by bupropion and BW 494 is antagonized by pimozide, but not by prazosin or D,L-propranolol. the antagonism of reserpine-induced hypothermia by bupropion and BW 306 is significantly decreased by prazosin and D,L-propranolol, but not by pimozide. These data suggest that the clinical antidepressant profile (without a major stimulatory effect) observed in man after administration of bupropion is related to metabolite BW 306 and possibly to BW 494, rather than to bupropion itself.
A Code Completion System for the Catrobat Visual Programming Language (2018)

Code completion systems are increasingly popular in the computer programming world. This thesis describes the design of a code completion system within the visual programming language Catrobat, with the aim of making programming more accessible to younger and less experienced users. This system was subsequently implemented into an application developed for Android devices, Pocket Code
Phytotoxic Response and Yield of Soybean (<i>Glycine max</i>) Varieties Treated with Sulfentrazone or Flumioxazin<sup>1</sup> (2001)

Flumioxazin and sulfentrazone were compared for phytotoxicity on 15 soybean varieties in a greenhouse study and four varieties in the field. In the greenhouse, injury from sulfentrazone was greater overall than with flumioxazin, 10% compared with 1%, respectively, when averaged across varieties at the labeled rates. The varieties P9552, P91B01, P9362, and P9305 were more sensitive to sulfentrazone than the 11 other varieties on the basis of visible injury and plant height reductions. Sulfentrazone at 224 g ai/ha (1× rate) reduced plant height 23 to 53% and caused 18 to 38% visible injury on the four sensitive varieties. Visible injury symptoms consisted of stunting, crinkling of leaves, and chlorotic spots. Varieties P9305, P9306, P9352, and P9362 were compared in a field study with flumioxazin at 105, 210, and 420 g ai/ha or sulfentrazone at 224, 448, and 896 g ai/ha, corresponding to 1, 2, and 4× labeled rates. An untreated control of each variety was included for comparison. Contrary to the results of the greenhouse studies, injury from flumioxazin was similar to that from sulfentrazone in the field experiments. In 1998, emergence counts were reduced 19 to 52% with flumioxazin and 27 to 73% with sulfentrazone at the 1× rate. Visible injury and stand count reductions resulting from both herbicides were also apparent in that year. Emergence count reductions, stand count reductions, and visible injury resulting from the herbicides were less severe in 1999. At the 1× rate of each herbicide, yields were not affect in either year, except P9305 treated with sulfentrazone in 1999. At the 4× rate, P9305 was most sensitive to sulfentrazone, as indicated by a 53 and 23% reduction yield in 1998 and 1999, respectively. Avoidance of sensitive varieties will reduce the potential for injury and yield reduction with sulfentrazone, and maybe flumioxazin.Nomenclature: Flumioxazin, 2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propynl)-2H-1,4 benzoxazin-6-yl[-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione; sulfentrazone, N-[2,4-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]phenyl] methanesulfonamide; soybean, Glycine max (L.).Additional index words: Protoporphyrinogen oxidase inhibitors, differential herbicide tolerance.Abbreviations: DAE, days after emergence; DAP, days after planting; DAT, days after treatment; PPO, protoporphyrinogen oxidase; PRE, preemergence.
A communicating Petri net model for the design of concurrent asynchronous modules (1994)

Current asynchronous tools are focussed mainly on the design of a single interface module. In many applications, one must design interacting interface modules that potentially communicate in complex and intricate ways. When designing communicating asynchronous modules, several difficult problems arise. First, even if each individual module can be synthesized correctly, according to the environmental assumptions specified for that module, the composition of the communicating modules may not work properly. Thus, one needs to have a way to model how the modules interact with each other, and to verify that their cooperation is consistent. In addition, means should be provided for communication and synchronization at a level higher than signal transitions, and for exploiting the communicating nature of these modules in optimization. This paper proposes a communicating Petri net model for describing communicating asynchronous modules. Each module is modeled by means of a labeled Petri net that extends the widely used Signal Transition Graph model by providing an abstract synchronization mechanism based on rendez-vous semantics. This enables the designer to specify high-level communication as well as low-level details such as signal transitions. Abstract synchronization events are expanded automatically to low-level handshake signals. We have developed a new algebra for communicating Petri nets that is applicable to general Petri nets, involves no unfolding, and defines hiding as generalized net contraction. We have developed methods based on this formal algebra that can be used to manipulate communicating interface modules, to verify their consistency, and to use them as a basis for optimizations.
Optimal Offloading Decision Strategies and Their Influence Analysis of Mobile Edge Computing (2019)

Mobile edge computing (MEC) has become more popular both in academia and industry. Currently, with the help of edge servers and cloud servers, it is one of the substantial technologies to overcome the latency between cloud server and wireless device, computation capability and storage shortage of wireless devices. In mobile edge computing, wireless devices take responsibility with input data. At the same time, edge servers and cloud servers take charge of computation and storage. However, until now, how to balance the power consumption of edge devices and time delay has not been well addressed in mobile edge computing. In this paper, we focus on strategies of the task offloading decision and the influence analysis of offloading decisions on different environments. Firstly, we propose a system model considering both energy consumption and time delay and formulate it into an optimization problem. Then, we employ two algorithms-Enumerating and Branch-and-Bound-to get the optimal or near-optimal decision for minimizing the system cost including the time delay and energy consumption. Furthermore, we compare the performance between two algorithms and draw the conclusion that the comprehensive performance of Branch-and-Bound algorithm is better than that of the other. Finally, we analyse the influence factors of optimal offloading decisions and the minimum cost in detail by changing key parameters.
The myc family of oncogenes and their presence and importance in small-cell lung carcinoma and other tumour types. (1993)

The myc family of cellular oncogenes, c-myc, N-myc, encodes three highly related, cell cycle specific, nuclear phospho-proteins. All are able to transform primary rat embryo fibroblasts when cotransfected with the c-ras oncogene. Myc family genes are differentially expressed with respect to tissue type and developmental stage and dramatic changes in their expression coincide with critical developmental transitions in many cell lineages. Their conservation as distinct genes over a large phylogenetic distance and their unique pattern of expression in developing embryos support the view that each member of the myc family may have an important and discrete biological activity. The nuclear localization and the presence of contiguous regions containing the basic region/helix-loop-helix/leucine zipper motifs suggest that myc-encoded proteins are involved in gene expression during growth and differentiation. The role of myc-oncogene amplification and/or overexpression in tumourigenesis is still not clear, but application of new biotechnological tools as transfection vectors and the antisense strategy may lead to a better understanding of the importance of the myc family of oncogenes. Transfection of cells with oncogenes in expression vectors conferring high levels of oncoprotein are used to analyze the influence of overexpression of the oncogene, while incubation with an appropriate antisense oligonucleotide leading to an inhibition of oncogene expression may give some clues to the necessity, function and importance of the oncogene. These two techniques have proven to be useful tools in the illumination of the function of these ubiquitous (proto-) oncogenes and probably will help to clarify at least a part of their role in, for instance, apoptosis, tumourigenesis and the development of resistance to antitumour drugs.
A clamp-on ultrasonic cross correlation flow meter for one-phase flow (1998)

The correlation technique presented offers a good possibility for measuring the average rate of flow of fluids through pipes. The only physical parameter required for the measurement principle is the well known distance between the sensors. The new system presented consists of ultrasonic sensors, transforming the natural, stochastic fluctuations of velocity, pressure and density into two signals with a delay time T, and a real-time correlator, extracting the delay time from the signals and calculating the average rate of flow of the fluid. In contrast to established flow measuring methods, no bluff bodies are necessary and electrical conductivity of the fluid is not required. In contrast to time-of-flight flow meters, a small amount of air bubbles or particles causes no signal losses and does not interrupt the measurement process. In this paper a detailed theoretical signal model describing the interaction of sound waves in random continuum and turbulent media will be presented. With this model the phase modulation of the ultrasonic waves and systematic errors can be described and some design parameters can be optimized. Measurements have been carried out with 40 and 50 mm pipe diameters for direct fluid contact and clamp-on transducers. The measurement error of the new flow meter has been found to be less than 2% from the reference value for a Reynolds number range 25 000-250 000 and, even down to a Reynolds number of 4000, it has been found to be less than 3%.
Legendre Polynomials based biometric authentication using QRS complex of ECG (2008)

In this paper we propose a new Legendre Polynomials based ECG biometric technique that can efficiently be used for person indentification and authentication. we apply high-order Legendre Polynomials on QRS Complex of ECG which is considered one of the most unique signature bearing parts. We show that coefficients generated from various degrees of polynomial matchings are unique for the same person but We show that coefficients generated from various degrees of polynomial matchings are unique for the same person but are significantly different from others. We also show that even with a 4th degree ploynomial fit person authenitication/identification is possible with high degree of accuracy. This is an interesting result as we can achieve significant reduction of key sizes when coefficients generated by these fits are used as unique keys for authentication and verification of subjects.
Integrated optic polymeric components fabricated with microstructured strip-off covers (1998)

Fabrication of integrated optic polymeric components by moulding waveguide and fibre alignment grooves to a substrate in a one-step process, and subsequently filling the waveguide grooves by means of a microstructured strip-off cover which is later removed, is presented. The latest measurement results on waveguide attenuation, coupling losses owing to passive fibre-waveguide coupling and excess loss values are given.
Structural Diversity of Ethinyl Estradiol Solvates (2008)

The (pseudo)polymorphism of ethinyl estradiol was investigated via extensive crystallization experiments. Four new crystal structures of ethinyl estradiol solvates that resulted from this study are presented. They contain dioxane, nitromethane, ethanol, or dimethylformamide. The crystal structures of the hemihydrate, methanolate, and acetonitrile solvate were redetermined to obtain the accurate hydrogen atom positions. The structural details of the different solvates of ethinyl estradiol were investigated in order to understand the scope of the solvate formation of ethinyl estradiol. Ethinyl estradiol forms many solvates, mostly with solvents having H-bond accepting or both accepting and donating propensity. Despite our rather comprehensive study, no true polymorph of ethinyl estradiol anhydrate was found.