gebhart/patrepeval huggingface dataset:
Properties (2002)

You have heard about data encapsulation. Roughly speaking, what it means is that all data members should be hidden behind public interfaces.
Online Scheduling for Reprographic Machines (1997)

Introduction We present a real-world online scheduling application. In this application, the problem input is fed incrementally to the scheduler, and the scheduler has only a portion of the entire job available before it has to start making scheduling decisions. In fact, job submission, scheduling and execution may all happen in parallel and at different speeds. We are investigating constraint-based online scheduling inthe domain of reprographic machines (photo-copiers, printers, and fax machines). The task of a generic reprographic ma hine scheduler isto schedule the operations that produce a given document in real-time. In particular, we focus on optimizing the make-span ofthe schedule, i.e., minimizing the output time of the last sheet. The make-span isusually taken as a measure of a machine’s productivity. Forhigh-end machines, productivity improvement often translates proportionally to an increase in perceived value. For expensive machines, even small improvements (e.g., by 5-10%) are significant. Constraint programming (Van Hentenryck 1989) and the large body of experience with constraint-based scheduling (Zweben & Fox 1994) provide a well-suited foundation for online scheduling. However, optimizing overall productivity s difficult inan online nvironment, and even more so with a real-time algorithm. Not only is it difficult to choose the right schedule without complete job information, but there may not even be enough time to find that schedule. This has motivated our work on heuristics for online scheduling (Getoor et al. 1997). Here, we point out further research directions in this area.
Output-feedback quantised control of decentralised systems (2012)

The problem of designing decentralised ℋ∞ feedback control for a class of linear interconnected continuous-time systems with quantised signals in the subsystem control channels is fully examined. The system has unknown-but-bounded couplings and interval delays. A decentralised static output-feedback controller is designed at the subsystem level to render the closed-loop system is delay-dependent asymptotically stable with guaranteed γ-level. When the local output measurements are quantised, we develop a local output-dependent procedure for updating the quantiser parameters to attain similar asymptotic stability and guaranteed performance of the closed-loop quantised system. Several special cases of interest are derived. Simulation of two representative examples are presented to show the effectiveness of the developed approach.
Dynamic control of hybrid MEMS gel actuator using thermoresponsive gel (2018)

In nature, Paramecium is moving by surface cilia. Human respiratory tract cells have cilia. Cilia eliminate foreign matter.From these facts, it is thought that cilia can be used as a microactuator. The pNIPAAm(N-Isopropylacrylamide) gel which is heat-responsive gel attracts attention as gel cause a volume change outside stimulation by temperature change and light and ph change. The hybrid structure consists of cilia structure SU-8 and a thermoresponsive gel. In conventional study changed whole gel. In this study, we control only one point of gel. The purpose of this study is to dynamically control the hybrid structure. Gel is controlled with a microheater array. We obtained a displacement of 806.1 μm at the hybrid structure. We were able to dynamically control any position of the gel. Future study will investigate the miniaturization of the device and the gel change by micro area heating.
The Cysteine-Cysteine Family of Chemokines RANTES, MIP-1α, and MIP-1β Induce Trypanocidal Activity in Human Macrophages via Nitric Oxide (1998)

This paper describes a new role for the cysteine-cysteine (CC) chemokines RANTES, MIP-1alpha, and MIP-1beta on human macrophage function, which is the induction of nitric oxide (NO)-mediated trypanocidal activity. In a previous report, we showed that RANTES, MIP-1alpha and MIP-1beta enhance Trypanosoma cruzi uptake and promote parasite killing by human macrophages (M. F. Lima, Y. Zhang, and F. Villalta, Cell. Mol. Biol. 43:1067-1076, 1997). Here we study the mechanism by which RANTES, MIP-1alpha, and MIP-1beta activate human macrophages obtained from healthy individuals to kill T. cruzi. Treatment of human macrophages with different concentrations of RANTES, MIP-1alpha, and MIP-1beta enhances T. cruzi trypomastigote phagocytosis in a dose peak response. The optimal response induced by the three CC chemokines is attained at 500 ng/ml. The macrophage trypanocidal activity induced by CC chemokines can be completely inhibited by L-N-monomethyl arginine (L-NMMA), a specific inhibitor of the L-arginine:NO pathway, but not by its D-enantiomer. Culture supernatants of chemokine-treated human macrophages contain increased NO2- levels, and NO2- production is also specifically inhibited by L-NMMA. The amount of NO2- induced by these chemokines in human macrophages is comparable to the amount of NO2- induced by gamma interferon. The killing of trypomastigotes by NO in cell-free medium is blocked by an NO antagonist or a NO scavenger. This data supports the hypothesis that the CC chemokines RANTES, MIP-1alpha, and MIP-1beta activate human macrophages to kill T. cruzi via NO, which is an effective trypanocidal mechanism.
Deuterium NMR as a probe of the stereochemistry of enzyme reactions at prochiral centers. Deaminaton of cadaverine, catalyzed by diamine oxidase (1978)

This work was supported by the National Research Council of Canada
Novel tripodal chelating ligand for appending and encapsulating metal ions. Crystal structure of a parachute-like hydrogen bonded complex (2000)

Tripodal ligand 1,3,5-tris(1-methylimidazol-2-ylmethyl)-2,4,6-trimethylbenzene (3) forms a parachute-like non-covalent complex with zinc tetrachloride, 5·[Zn2Cl6]0.5, where the imidazoles of the ligand are protonated and bind to the metal ion through NH···Cl hydrogen bonds.
Studies on the Reactions of Heterocyclic Compounds. X. 1, 3-Dipolar Cycloaddition Reaction of Isoquinolinium Ylides and Dicyanoacetylene (1973)

The 1, 3-dipolar cycloaddition of dicyanoacetylene (IIb) to isoquinolinium ylides did not give the primary adduct but the aromatized and/or isomerized products. Further, in the reaction of isoquinolinium bis(methoxycarbonyl)methylide (Ia), possibly a rearranged addition product, 1, 10b-dihydropyrrolo[2, 1-α]isoquinoline (VII), was obtained beside 2, 3-dihydropyrrolo[2, 1-α]isoquinoline (Va) and pyrrolo[2, 1-α]isoquinoline (VIa). In the reaction of isoquinolinium cyano(methoxycarbonyl)methylide (Ib), 2, 3-dihydropyrrolo[2, 1-α]isoquinoline (VIII), formed by the liberation of a methoxycarbonyl group, was obtained in addition to VIa and pyrrolo[2, 1-α]isoquinoline-1, 2, 3-tricarbonitrile (VIb).
Azole plasma concentrations in lung transplant recipients (2014)

Background: The absorption of azoles is subject to a high inter- and intra-individual variability. However, therapeutic drug monitoring [TDM] is not routinely performed. The purpose of this observation was to analyse azole plasma levels [APL] in lung transplant recipients [LTR]. Methods: 116 LTR of our lung transplantation [LTx] follow-up program who underwent TDM (65 male, 84 double-LTx, 3.1±3.5 years after LTx, age 49.7±14.9 years, underlying disease [ULD]: idiopathic pulmonary fibrosis [IPF; n=34; 29%], cystic fibrosis [CF; n=29; 25%], chronic obstructive pulmonary disease [COPD; n=28; 24%], other [n=25; 22%]) were evaluated. The target plasma levels [TPL] of azoles were defined as follows: Itraconazole [ITR] and Voriconazole [VOR] >1000µg/L, Posaconazole [POS] >700µg/L. APL were assayed using high performance liquid chromatography. Results: The mean APL for ITR, VOR, and POS were 715.4±866.1µg/L, 1649.2±1300.5µg/L and 903.4±780.9µg/L, respectively. Most frequent use was noted for ITR (n=55; 47%). The following results are classified by azole and ULD: CF ITR n below TPL 13 n=29 % below TPL 87 n total 15 VOR n below TPL 5 % below TPL 42 n total 12 POS n below TPL 1 % below TPL 50 n total 2 COPD ITR n below TPL 8 n=28 % below TPL 67 n total 12 VOR n below TPL 3 % below TPL 43 n total 7 POS n below TPL 5 % below TPL 56 n total 9 IPF ITR n below TPL 13 n=34
Application of FASTTM Fragment-Based Lead Discovery and Structure-Guided Design to Discovery of Small Molecule Inhibitors of BCR-ABL Tyrosine Kinase Active Against the T315I Imatinib-Resistant Mutant. (2005)

Abstract The Philadelphia chromosome translocation creates a BCR-ABL fusion gene that encodes a constitutively active BCR-ABL tyrosine kinase, which gives rise to chronic myelogenous leukemia (CML). The clinical success of imatinib (Gleevec) demonstrated that BCR-ABL tyrosine kinase inhibitors can provide effective treatment for CML. However, some CML patients treated with imatinib develop resistance leading to disease progression. The majority of resistance is due to point mutations in BCR-ABL, which give rise to active mutant enzymes that are insensitive to imatinib. In all, ~30 imatinib-resistant BCR-ABL mutants have been identified in clinical isolates. The T315I mutant represents ~20% of clinically observed mutations, making it one of the most common causes of resistance. Second-generation BCR-ABL inhibitors, including AMN-107 and BMS-354825, inhibit many of the clinically relevant mutants but not T315I. Mutant T315I BCR-ABL is, therefore, an important and challenging target for discovery of CML therapeutics. We have applied a proprietary X-ray crystallographic fragment-based lead discovery platform (FASTTM) and structure-guided lead optimization to identify potent inhibitors of wild-type BCR-ABL and the four most common mutants, including T315I. Our lead discovery efforts yielded five chemical series that inhibit both wild-type (WT) and T315I BCR-ABL. Compounds in our most advanced lead series potently inhibit proliferation of K562 cells and Ba/F3 cells with WT BCR-ABL and the four major clinically relevant BCR-ABL mutations (T315I, E255K, M351T, Y253F; see below). Further details describing in vitro and in vivo profiling of these novel BCR-ABL T315I inhibitors will be presented. Ba/F3 cell proliferation for BCR-ABL Inhibitors (EC50, nM) BCR-ABL Form Imatinib AMN-107 BMS-354825 SGX-70430 WT 790 33 12 11 T315I > 10000 > 10000 > 10000 21 Y253F 5700 370 8 334 E255K 8300 350 7 77 M351T 2000 38 28 15 Control Assay Ba/F3 (T315I) + IL3 > 10000 > 10000 > 10000 > 10000
Multivariate Analyses of Rotator Cuff Pathologies in Shoulder Disability (2015)

Our study reveals that infraspinatus atrophy has the strongest contribution to RC tear pathologies. This suggests a pivotal role for the infraspinatus in preventing shoulder disability.
Reducing Theory to Practice—Luminaire Dirt Depreciation and Maintenance (1975)

The combined facts of the energy crisis, its effect on lighting, and recent articles on luminaire dirt depreciation form a timely combination of events. The basis for this article is that these events should be brought to the attention of lighting equipment users and specifiers to improve present and planned installations.
Optical properties of highly luminescent zinc oxide tetrapod powders (2007)

Zinc oxide tetrapod powders with high luminescent characteristics have been grown by simple evaporation and direct oxidation of zinc. Their structural and optical properties have been studied by transmission electron microscopy and by cathodoluminescence. The legs of the tetrapods have a pure hexagonal structure and form an arrowhead joint at the center. The tetrapod legs exhibit strong band edge and weak green luminescence. Monochromatic cathodoluminescence images show that the band-edge emission originates from the bulk of the legs, while the green emission emanates from the surface, indicative of it being related to oxygen vacancies. Low temperature cathodoluminescence shows a direct correlation of near-band-edge emission with specific sites within the structure.
Incorporating a Human Risk Factor in Avalanche Danger Rating Systems (2000)

Our results implicate variants in TBX4 as a genetic cause of PAH in a subset of the Japanese population. Variants in TBX4 may lead to PAH through insufficient lung morphogenesis by disrupting the TBX4-mediated direct regulation of FGF10 signalling and pulmonary vascular endothelial dysfunction involving PAH-related molecules.
Structure of the compound purported to be NN-bis(chloromethyldimethylsilyl)-acetamide: X-ray crystal structure analysis of the novel five-membered oxygen-, silicon-, and nitrogen-containing heterocycle (O–Si)-chloro-[(N-chlorodimethylsilylacetamido)methyl]dimethylsilane (1978)

The compound erroneously reported as NN-bis(chloromethyldimethylsilyl)acetamide has been proven by single-crystal X-ray analysis to be (O–Si)-chloro-[(N-chlorodimethylsilylacetamido)methyl]dimethylsilane.
Enhanced glucose control for preventing and treating diabetic neuropathy (2012)

According to high-quality evidence, enhanced glucose control significantly prevents the development of clinical neuropathy and reduces nerve conduction and vibration threshold abnormalities in type 1 diabetes mellitus. In type 2 diabetes mellitus, enhanced glucose control reduces the incidence of clinical neuropathy, although this was not formally statistically significant (P = 0.06). However, enhanced glucose control does significantly reduce nerve conduction and vibration threshold abnormalities. Importantly, enhanced glucose control significantly increases the risk of severe hypoglycemic episodes, which needs to be taken into account when evaluating its risk/benefit ratio.
The influence of frontal alignment in the advanced reciprocating gait orthosis on energy cost and crutch force requirements during paraplegic gait (1997)

Reduction of energy cost and upper body load during paraplegic walking is considered to be an important criterion in future developments of walking systems. A high energy cost limits the maximum walking distance in the current devices, whereas wrist and shoulder pathology can deteriorate because of the high upper body load. A change in alignment of the mechanical brace in the frontal plane, i.e. abduction, can contribute to a more efficient gait pattern with sufficient foot clearance with less pelvic lateral sway. A decrease in pelvic lateral sway after aligning in abduction results in a shift of the centre of mass to the swing leg crutch which may result in a decrease in required crutch force on stance side to maintain foot clearance. Five paraplegic subjects were provided with a standard Advanced Reciprocating Gait Orthosis (ARGO) and an ARGO aligned in 4 different degrees of abduction (0°, 3°, 6° and 9°). After determining an optimal abduction angle for each of the subjects, a cross over design was used to compare the ARGO with the individually optimised abducted orthosis. An abduction angle between 0° and 3° was chosen as optimal abduction angle. Subjects were not able to walk satisfactory with abduction angles 6° and 9°. A significant reduction in crutch peak force on stance side was found (approx. 12% , p < 0.01) in the abducted orthosis. Reduction in crutch force time integral (15%) as well as crutch peak force on swing side (5%) was not significant. No differences in oxygen uptake as well as oxygen cost was found. We concluded that an abduction angle between 0° and 3° is beneficial with respect to upper boHy load, whereas energy requirements did not change.
Cholesterol-mediated regulation of HMG-CoA reductase in microsomes from human skin fibroblasts and rat liver (1990)

3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase activity was determined in microsomes from human skin fibroblasts and rat liver that had been variously manipulated in vivo or in tissue culture to up- and down-regulate the enzyme. The cholesterol content of these microsomal preparations was then altered by depletion to or enrichment from either cholesterol-free or cholesterol-rich lipid vesicles. Microsomes from human skin fibroblasts responded to cholesterol depletion by increasing HMG-CoA reductase activity and by decreasing it in response to cholesterol enrichment. This was independent of the initial enzyme activity or the tissue culture conditions. Alterations in cholesterol content of rat liver microsomes in vitro failed to demonstrate any significant changes in HMG-CoA reductase activity whether the microsomes started with low enzyme activity (cholesterol-fed rats) or with high enzyme activity (cholestyramine-treated rats). The results are discussed in relation to previously published data and in respect to differences in the control of the human skin fibroblast and rat liver enzymes.
Generation of high energy and high quality ultrashort pulses in moderately non-linear FCPA (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Y. Zaouter, J. Boullet, E. Mottay, and E. Cormier, "Generation of high energy and high quality ultrashort pulses in moderately non-linear FCPA," in Advanced Solid-State Photonics, OSA Technical Digest Series (CD) (Optical Society of America, 2009), paper MB17. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Transfection of E. coli with lambda DNA by electroporation. (1992)

In the ambit of the B. subtilis genoma sequencing and mapping project, we have set up an electroporation method to transfect E. coli cells with lambda DNA. This methodology presents features that make it preferable to traditional in vitro packaging for some purposes. Here we will illustrate the experimental procedure and the possible applications.
Trans effect of the good .sigma. donor ligands dimethyl phosphate, methyl phenyl phosphonate, and diphenylphosphinate. Evidence for complete bond breaking in the transition state of SN1lim reactions of dimethylphosphonatocobaloxime and methylcobaloxime complexes (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrans effect of the good .sigma. donor ligands dimethyl phosphate, methyl phenyl phosphonate, and diphenylphosphinate. Evidence for complete bond breaking in the transition state of SN1lim reactions of dimethylphosphonatocobaloxime and methylcobaloxime complexesWilliam C. Trogler, Robert Charles Stewart, and Luigi G. MarzilliCite this: J. Am. Chem. Soc. 1974, 96, 11, 3697–3699Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://pubs.acs.org/doi/10.1021/ja00818a080https://doi.org/10.1021/ja00818a080research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Studies on Positive Inotropic Agents. Part 5. Synthesis of 1‐Heteroaroylpiperazine Derivatives. (1989)

Abstract Acylation of the bicyclic heteroarenones (I) with chloroacetyl chloride (II) yields the chloromethyl ketones (III).
Studies on psychomotoric effects and pharmacokinetic interactions of the new calcium sensitizing drug levosimendan and ethanol. (1997)

Levosimendan (CAS 141505-33-1) is a calcium sensitizing drug intended for the treatment of congestive heart failure. In animal experiments levosimendan has potentiated the sedative effects of ethanol. Due to poor water solubility of the compound, ethanol is used as a diluent in the intravenous formulation. In this study the possible interactions between levosimendan and ethanol in human have been studied. Twelve healthy male volunteers were included in this double-blind, randomized, cross-over study. The study consisted of three treatment periods: levosimendan 1 mg intravenously, levosimendan combined with ethanol orally and ethanol 0.8 g/kg alone. Blood samples for determination of levosimendan and ethanol concentrations were collected for 8 h after the dosing. To observe possible pharmacodynamic interactions psychomotoric tests were made before drug administration and 1h, 2h, 3h and 6h thereafter. These tests included Digit symbol substitution test, Maddox wing, Critical Flicker fusion and VAS-test for subjective assessment of performance status. Plasma levosimendan concentrations were not changed by the concomitant ethanol administration. Ethanol did not alter the pharmacokinetics of levosimendan except the volume of distribution of central compartment which was decreased. Levosimendan did neither affect elimination of ethanol. Levosimendan did not potentiate the psychomotoric effects of ethanol neither did it have any psychomotoric effects itself. In conclusion, levosimendan is not likely to have any psychomotoric adverse effects or any clinically significant interactions with ethanol.
Antihistamine constriction in mouse skin microcirculation (1968)

Journal Article Antihistamine constriction in mouse skin microcirculation Get access Burton M Altura Burton M Altura Departments of Anesthesiology and Physiology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, New York 10461, USA Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 20, Issue 1, January 1968, Pages 71–72, https://doi.org/10.1111/j.2042-7158.1968.tb09624.x Published: 12 April 2011 Article history Received: 24 October 1967 Published: 12 April 2011
An Evaluation of the Effect of Gonadotropin-Releasing Hormone Analogs and Medroxyprogesterone Acetate on Uterine Leiomyomata Volume by Magnetic Resonance Imaging (1993)

Carr, Bruce R.; Marshburn, Paul B.; Weatherall, Paul T.; Bradshaw, Karen D.; Breslau, Neil A.; Byrd, William; Roark, Micki; Steinkampf, Michael P. Author Information
What clinical factors predict the incidence of deep venous thrombosis and pulmonary embolism in neurosurgical patients? (2014)

Venous thromboembolism is a common complication in neurosurgical patients, and the frequency has not changed appreciably over the past several years. Many factors were identified as independently predictive of VTEs in this population: ventilator dependence, immobility, and malignancy. Less anticipated predictors included chronic steroid use and sepsis. Venous thromboembolisms appear significantly more likely to occur in patients undergoing cranial procedures than in those undergoing spinal procedures. A better appreciation of the prevalence of and the risk factors for VTEs in neurosurgical patients will allow targeting of interventions and a better understanding of which patients are most at risk.