gebhart/patrepeval huggingface dataset:
Effects of 5-fluorouracil on the hematopoietic system of the mouse. (1960)

Summary Mice bearing Ehrlich ascites tumor either sensitive or resistant to 5-fluorouracil (5-FU) were treated with the drug in a dose of 40 mg/kg/day for 6 days. The peripheral blood of the treated mice showed a marked reduction of leukocytes and platelets and a slight decrease in hemoglobin. After this treatment, the bone marrow of these mice was depleted of differentiating and maturing cells with but a few immature cells, lymphocytes, segmented leukocytes, and megakaryocytes remaining. The immature bone marrow cells which remained were found to be enlarged. With histochemical staining it was shown that the concentration of deoxyribonucleic acid was decreased, whereas the concentration of ribonucleic acid and basic proteins appeared to be the same as in bone marrow cells from control mice. Morphologically, the mature cells appeared intact, whereas the immature cells showed degenerative changes.
Kinetics of binding of chicken cystatin to papain (1989)

The kinetics of binding of chicken cystatin to papain were studied by stopped-flow fluorometry under pseudo-first-order conditions, i.e., with an excess of inhibitor. All reactions showed first-order behavior, and the observed pseudo-first-order rate constant increased linearly with the cystatin concentration up to the highest concentration that could be studied, 35 microM. The analyses thus provided no evidence for a limiting rate resulting from a conformational change stabilizing an initial encounter complex, in contrast with previous studies of reactions between serine proteinases and their protein inhibitors. The second-order association rate constant for complex formation was 9.9 X 10(6) M-1 s-1 at 25 degrees C, pH 7.4, I = 0.15, for both forms of cystatin, 1 and 2. This value approaches that expected for a diffusion-controlled rate. The temperature dependence of the association rate constant gave an enthalpy of activation at 25 degrees C of 31.5 kJ mol-1 and an entropy of activation at 25 degrees C of -7 J K-1 mol-1, compatible with no appreciable conformational change during the reaction. The association rate constant was independent of pH between pH 6 and 8 but decreased at lower and higher pH in a manner consistent with involvement of an unprotonated acid group with a pKa of 4-4.5 and a protonated basic group with a pKa of 9-9.5 in the interaction. The association rate constant was unaffected by ionic strengths between 0.15 and 1.0 but decreased somewhat at lower ionic strengths. Incubation of the complex between cystatin 2 and papain with an excess of cystatin 1 resulted in slow displacement of cystatin 2 from the complex.(ABSTRACT TRUNCATED AT 250 WORDS)
Development of a multimedia document management system for cooperative work environment (2003)

The authors discuss a technical document management system where a large volume of documents are maintained by cooperative efforts of work groups using DTP (desktop publishing) software. The implementation of Jenesys is discussed. Jenesys is a technical document management and authoring system for aircraft maintenance information which consists of more than 100 types of documents. The major characteristics of Jenesys are the database of documents, integration of DTP software to create high-quality documents, and document creation/revision by cooperative efforts of work groups. The RDB+pointer method is a powerful, orthodox solution based on the assumption that approved documents cannot be modified without creating a new record for the revision. By adopting this method as the basic structure of the document database, this technical document management system was designed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Genetic Variability of HIV-1 for Drug Resistance Assay Development (2016)

A hybridization-based point-of-care (POC) assay for HIV-1 drug resistance would be useful in low- and middle-income countries (LMICs) where resistance testing is not routinely available. The major obstacle in developing such an assay is the extreme genetic variability of HIV-1. We analyzed 27,203 reverse transcriptase (RT) sequences from the Stanford HIV Drug Resistance Database originating from six LMIC regions. We characterized the variability in a 27-nucleotide window surrounding six clinically important drug resistance mutations (DRMs) at positions 65, 103, 106, 181, 184, and 190. The number of distinct codons at each DRM position ranged from four at position 184 to 11 at position 190. Depending on the mutation, between 11 and 15 of the 24 flanking nucleotide positions were variable. Nonetheless, most flanking sequences differed from a core set of 10 flanking sequences by just one or two nucleotides. Flanking sequence variability was also lower in each LMIC region compared with overall variability in all regions. We also describe an online program that we developed to perform similar analyses for mutations at any position in RT, protease, or integrase.
Motion primitive based random planning for loco-manipulation tasks (2016)

Several advanced control laws are available for complex robotic systems such as humanoid robots and mobile manipulators. Controls are usually developed for locomotion or for manipulation purposes. Resulting motions are usually executed sequentially and the potentiality of the robotic platform is not fully exploited. In this work we consider the problem of loco-manipulation planning for a robot with given parametrized control laws known as primitives. Such primitives, may have not been designed to be executed simultaneously and by composing them instability may easily arise. With the proposed approach, primitives combination that guarantee stability of the system are obtained resulting in complex whole-body behavior. A formal definition of motion primitives is provided and a random sampling approach on a manifold with limited dimension is investigated. Probabilistic completeness and asymptotic optimality are also proved. The proposed approach is tested both on a mobile manipulator and on the humanoid robot Walk-Man, performing loco-manipulation tasks.
Cyclische Ether als Edukte zur Synthese von Schmetterlings-Pheromonen (1991)

Cyclic Ethers as Educts for the Synthesis of Lepidoptera Pheromones ω-Iodo(trialkylsiloxy)alkanes 2 prepared by ring opening of cyclic ethers with iodotrimethylsilane, are useful starting materials for the synthesis of pheromone components. Reaction with triphenylphosphine to give the corresponding Wittig reagent and subsequent coupling with lithium (Z)-dihex-1-enylcuprate gives (Z)-alken-1-ols 5 and 7, after deprotection, in good yields. The direct coupling of 2 with alkynes failed because of competition reactions, however, the more stable ω-iodo-1-(tert-butyldimethylsiloxy)alkanes were able to undergo C,C-coupling with alkynes. The thus formed 1-(tert-butyldimethylsiloxy)-5-decyne (13c) was hydrogenated and deprotected to give (E)-5-decen-1-ol (15c).
Effect of overtime work on cognitive function in automotive workers (1996)

The findings support the hypothesis that overtime work results in impaired cognitive performance in the areas of attention and executive function and that both overtime hours and the number of consecutive days worked prior to a test day affect mood.
Antarctic Ice and the Global Climate System (2002)

The Australia's Antarctic program has covered numerous studies for explaining the impact of Antarctica on the climate system of the globe. The various abrupt changes that have taken place in the region and in the world are also analyzed.
Product Lifecycle Analysis and Optimization in an Eco-value Based, Sustainable and Unified Approach (2006)

The current capabilities in most small and medium enterprises in industry are inadequate to meet the sustainable growth challenges from customers, competitors, or from government legislation requirements in the near future. This paper explores new product lifecycle technologies to address the challenges above. An eco-value based and unified product sustainability enhancement approach is proposed that enables comprehensive product lifecycle analysis and optimization. The novelty of the proposed approach is the semantics-based evolvement optimization method which is generic and adaptable to any sustainability issues.
Diffusion in Polymers (1996)

Diffusion in homogenous membranes molecular simulations of sorption and diffusion in amorphous polymers free-volume theory transport phenomena in polymer membranes supermolecular structure of polymer solids and its effects on penetrant transport translational dynamics of macromolecules in melts.
Solubility of Hydrogen, Oxygen, Nitrogen, and Helium in Water at Elevated Temperatures (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of Hydrogen, Oxygen, Nitrogen, and Helium in Water at Elevated TemperaturesH. A. Pray, C. E. Schweickert, and B. H. MinnichCite this: Ind. Eng. Chem. 1952, 44, 5, 1146–1151Publication Date (Print):May 1, 1952Publication History Published online1 May 2002Published inissue 1 May 1952https://pubs.acs.org/doi/10.1021/ie50509a058https://doi.org/10.1021/ie50509a058research-articleACS PublicationsRequest reuse permissionsArticle Views4359Altmetric-Citations248LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Nosocomial Bloodstream Infection and Clinical Sepsis (2004)

Primary bloodstream infection (BSI) is a leading, preventable infectious complication in critically ill patients and has a negative impact on patients' outcome. Surveillance definitions for primary BSI distinguish those that are microbiologically documented from those that are not. The latter is known as clinical sepsis, but information on its epidemiologic importance is limited. We analyzed prospective on-site surveillance data of nosocomial infections in a medical intensive care unit. Of the 113 episodes of primary BSI, 33 (29%) were microbiologically documented. The overall BSI infection rate was 19.8 episodes per 1,000 central-line days (confidence interval [CI] 95%, 16.1 to 23.6); the rate fell to 5.8 (CI 3.8 to 7.8) when only microbiologically documented episodes were considered. Exposure to vascular devices was similar in patients with clinical sepsis and patients with microbiologically documented BSI. We conclude that laboratory-based surveillance alone will underestimate the incidence of primary BSI and thus jeopardize benchmarking.
HOO 2012: A Report on the Preposition and Determiner Error Correction Shared Task (2012)

Incorrect usage of prepositions and determiners constitute the most common types of errors made by non-native speakers of English. It is not surprising, then, that there has been a significant amount of work directed towards the automated detection and correction of such errors. However, to date, the use of different data sets and different task definitions has made it difficult to compare work on the topic. This paper reports on the HOO 2012 shared task on error detection and correction in the use of prepositions and determiners, where systems developed by 14 teams from around the world were evaluated on the same previously unseen errorful text. 1
Simultaneous switching noise in CMOS VLSI circuits (2003)

In this paper, we present techniques for estimating the worst-case voltage variations in the power distribution network due to switching of I/O buffers or internal logic circuits in a small time interval. We refer to these voltage variations as the simultaneous switching noise (SSN). We present simulation results to show that a relative skew in the switching time can dramatically increase the SSN due to I/O buffers with dissimilar loads. We also present a constraint graph based technique that accounts for logic dependencies between switching elements to obtain accurate estimates of the worst-case SSN due to internal logic circuits. Comparisons with SPICE simulations are presented to validate our approach.
Pharmaceutical Cocrystals: An Overview (2017)

Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient are the major constraints during the development of new product. Various approaches have been used for enhancement of solubility of poorly aqueous soluble drugs, but success of these approaches depends on physical and chemical nature of molecules being developed. Cocrystallization of drug substances offers a great opportunity for the development of new drug products with superior physicochemical such as melting point, tabletability, solubility, stability, bioavailability and permeability, while preserving the pharmacological properties of the active pharmaceutical ingredient. Cocrystals are multicomponent systems in which two components, an active pharmaceutical ingredient and a coformer were present in stoichiometric ratio and bonded together with non-covalent interactions in the crystal lattice. This review article presents a systematic overview of pharmaceutical cocrystals. Differences between cocrystals with salts, solvates and hydrates are summarized along with the advantages of cocrystals with examples. The theoretical parameters underlying the selection of coformers and screening of cocrystals have been summarized and different methods of cocrystal formation and evaluation have been explained.
Implementation of high performance false contour reduction system using pattern analysis and error-predict method for PDP-HDTV (2003)

This paper proposes a high performance false contour reduction system with pattern analysis algorithm for PDP-HDTV. It also presents the optimized design and implementation of the method. The proposed method is verified using the Xilinx. Virtex-II FPGA XC2V2000-BG575. Furthermore, we suggest an advanced error-prediction algorithm for high performance. This method is demonstrated experimentally for a 50" PDP-HDTV.
Zanamivir: from drug design to the clinic (2001)

The development of the neuraminidase inhibitors has revolutionized the management options for influenza. Zanamivir was the first such inhibitor to be approved for the treatment of influenza in humans. It is delivered by inhalation to the respiratory tract, which is the site of viral replication, in order to ensure immediate antiviral activity. Early treatment with zanamivir in clinical trials rapidly reduced the severity and duration of influenza symptoms and associated complications. Furthermore, chemoprophylaxis with zanamivir was shown to be effective in the prevention of influenza illness. To date, there is no evidence for the emergence of clinically significant zanamivir-resistant isolates. In conclusion, zanamivir offers a useful complementary strategy to vaccination in the effective management of influenza.
Routine Screening of Adolescents for Trichomonas vaginalis in a Juvenile Detention Center (2019)

Background: Detained and incarcerated adolescents are at increased risk of sexually transmitted infections (STI), but limited information is currently available regarding the prevalence of Trichomonas vaginalis (TV) in detained youth.Methods: A total of 144 detainees (75 males and 69 females) in the Franklin County Juvenile Detention Facility (FCJDF) in Columbus, Ohio, consented to STI screening between May 2016 and June 2017. Participants were screened for TV in addition to Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) using urine nucleic acid amplification tests (NAAT).Results: Among detained youth who consented to testing, TV was identified in 7 of 69 (10.1%) females and 0 of 75 (0%) males (P <0.01). Neisseria gonorrhoeae was identified in 12 of 69 (17.4%) females and 3 of 75 (4.0%) males (P = 0.01), and CT was identified in 16 of 69 (23.2%) female and 7 of 75 (9.3%) male detainees (P = 0.04). Among females, positive TV screen was associated with prior history of STI.Conclusion: Our data support routine screening of female detainees at FCJDF, based on our finding of 10% posi-tivity among females who underwent testing.
A New Digital Echo Canceler for Two-Wire Full-Duplex Data Transmission (1976)

A new approach to echo canceling for two-wire fullduplex data transmission is proposed. The canceling signal is directly synthesized from the binary data, using a transversal filter approach, and the usual multiplications are replaced by additions and subtractions, thus allowing efficient operation of a large number of taps as required for the canceling of distant echoes. As a specific application, a system processing one sample per baud is discussed where timing signals at both communicating stations are assumed to be synchronized. A stochastic adjustment gradient-type algorithm is used for both training and adaptive tracking of the canceler. It is shown that convergence does not depend on intersymbol interference, timing phase, carrier phase, or the energy ratio of the local to the received signal, but is a function only of the number of taps. Convergence time is proportional to that number, and the optimum step size for fastest convergence is equal to the reciprocal of the number of taps. The residual fluctuation noise is proportional to that part of the mean-square (MS) error which cannot be reduced by the canceler and is a simple function of the product of the tap signal and the step size. The predicted convergence properties are verified by simulation results. Finally, it is shown how such an echo canceler might be used to allow two-wire full-duplex transmission for data rates as high as 4800 bit/s.
Swimming and cardiovascular fitness in the older age group (1975)

Coronary artery disease is an extraordinarily common and devastating disorder of middle aged and even young men in the United States and Western Europe. An increasing risk of developing the disease is associated with such factors as high blood pressure, obesity, high levels of cholesterol in the blood serum, cigarette smoking, certain behavioral patterns, decreased vital capacity and a low level of physical activity. There is much evidence to indicate that exercise may well help prevent heart attacks through such mechanisms as increasing heart efficiency, decreasing the level of serum cholesterol, decreasing obesity, decreasing high blood pressure and promoting psychic well-being. It is necessary, however, that the exercise be continued throughout life. Athletic activity in high school or college is of no help in later years. The exercise must be part of a regular scheduled year-round activity. It is suggested that swimming has many unique advantages for such an endeavor. The Amateur Athletic Union of the United States has developed competition in older age groups as a motivating force for the continuance of a regular training program of a healthful nature.
A scenario aggregation based approach for determining a robust airline fleet composition (2002)

Strategic airline fleet planning is one of the major issues addressed \nthrough newly initiated decision support systems, designed to assist \nairlines and aircraft manufacturers in assessing the benefits of the \nemerging concept of dynamic capacity allocation. We present background \nresearch connected with such a system, which aims to explicitly account \nfor the stochastic nature of passenger demand in supporting decisions \nrelated to the fleet composition problem. We address this problem through \na scenario aggregation based approach and present results on representative \ncase studies based on realistic data. Our investigations establish clear \nbenefits of a stochastic approach as compared with deterministic formulations, \nas well as its implementation feasibility using state-of-the-art\noptimization software.
The and Block Ciphers on AVR 8-bit Microcontrollers ? (2014)

The last several years have witnessed a surge of activity in lightweight cryptographic design. Many lightweight block ciphers have been proposed, targeted mostly at hardware applications. Typically soft- ware performance has not been a priority, and consequently software performance for many of these algorithms is unexceptional. Simon and Speck are lightweight block cipher families developed by the U.S. Na- tional Security Agency for high performance in constrained hardware and software environments. In this paper, we discuss software performance and demonstrate how to achieve high performance implementations of Simon and Speck on the AVR family of 8-bit microcontrollers. Both ci- phers compare favorably to other lightweight block ciphers on this plat- form. Indeed, Speck seems to have better overall performance than any existing block cipher | lightweight or not.
Thermodynamics, An Introduction to the Physical Theories of Equilibrium Thermostatics and Irreversible Thermodynamics (1960)

First Page
Effects of hyperbaric oxygenation and tissue oxygen studies in experimental paraplegia (1972)

✓ This study demonstrates that the tissue pO 2 of the normal spinal cord of dogs can be modified by ventilating the animals with oxygen and carbogen. Following trauma to the cord, the tissue pO 2 responded only to hyperbaric oxygen. A series of animals rendered paraplegic and treated with hyperbaric oxygen recovered to a greater degree than those in an untreated control group.
Tentative diet for liver failure containing well-polished rice. (1996)

A liver-failure diet (low in protein) that contained rice polished to 50% to reduce the protein content of the diet was given to patients with uncompensated liver cirrhosis and compared with a standard liver-failure diet containing conventionally processed rice. The amount of boiled rice served in each meal could be increased by using well-polished rice and the use of supplementary sources of energy (powdered starch syrup, jelly, cookies, and candy sugar) was unnecessary. In the liver-failure diet containing well-polished rice, the methionine contents could be reduced and the Fischer ratio could be increased. The ingestion rate of the diet with well-polished rice was 80% and the diet was rated favorably in a questionnaire on palatability. Decreases in blood ammonia concentrations were observed in three patients given the liver-failure diet with well-polished rice for 2 wk by the crossover method.
Computer-aided electrical design of power processing systems (2003)

A computer-based approach to power supply design is presented and illustrated with a high-power forward converter example. The approach demonstrates a highly effective method of using computers to achieve design optimization while reducing design time and cost. A system-level simulation tool, based on generalized averaged models, is also presented and its use is illustrated with hardware measurements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>