gebhart/patrepeval huggingface dataset:
P2‐397: MICE IMMUNIZED WITH CYCLIC‐SER‐ASN‐LYS (CSNK) PEPTIDE GENERATE POLYCLONAL ANTIBODIES SELECTIVE FOR Aβ OLIGOMERS: A VACCINE STRATEGY FOR ALZHEIMER'S DISEASE (2014)

Soluble Aβ oligomers mediate most synaptotoxic and neurotoxic effects of Aβ in AD. We have shown that the mouse monoclonal antibody mAb5E3 generated against the structurally constrained tripeptide cSNK specifically recognizes synthetic and native Aβ oligomers, but not SNK in fibrils, monomers or amyloid precursor protein, and also neutralizes Aβ oligomer toxicity. We now determine the proportion of mAb-5E3-type immunoreactivity in polyclonal sera from cSNK-immunized mice. Four mice were immunized subcutaneously every 3 weeks with cSNK peptide conjugated to keyhole limpet hemocyanin (KLH) + Emulsigen adjuvant, and sera collected by tail vein phlebotomy after 9 weeks. Using a Biacore™ 3000, we immobilized equal densities of cyclic or linear SNK conjugated to BSA, Aβ40 monomer and BSA (reference surface) on 4 separate flow cells of a biosensorchip. Immunized mouse serum, normal mouse serum, mAb5E3 and 2 commercially-available antibodies that bind Aβ peptide (mAb6E10 and mAb4G8) were then diluted, sequentially injected over the different immobilized peptides and antibody binding monitored in real time. In another set of experiments, we compared the binding of these antibodies to an Aβ42 oligomer preparation (containing monomers, low and high molecular weight oligomers) and to Aβ40 monomers. Immunized mice exhibited 6-fold and 34-fold higher binding to cSNK than to linear SNK and to Aβ monomer, respectively. Normal mouse serum demonstrated no binding to cyclic or linear SNK, but bound to Aβ40 monomers at levels similar to the immune serum. mAb5E3 bound with a high magnitude to cSNK, but did not bind to either linear SNK, nor Aβ monomer. Immune serum and mAb5E3 bound 4-fold and 8-fold higher respectively, to the Aβ42 oligomers than to the Aβ40 monomers. mAb6E10 and mAb4G8 showed no binding to cyclic or linear SNK, which is not contained in their cognate epitopes, but bound strongly to the Aβ monomer. Our study reveals that active immunization with the conformationally-constrained cSNK peptide generates antibodies that selectively recognize the cSNK oligomer-specific epitope, while sparing SNK recognition in other Aβ contexts, suggesting that the cyclic peptide could be a suitable immunogen for oligomer-specific therapeutic or prophylactic vaccines for Alzheimer's disease.
Chebyshev Polynomial Fit for Terrain Elevation. (1996)

Abstract : There is currently a desire to use Chebyshev polynomials to fit terrain elevation data. Such a fit would create a surface function that exactly fits the known elevations, and would describe an elevation at any point on that surface. This note questions the appropriateness of using Chebyshev polynomials for this purpose, as opposed to linear interpolation or use of a cubic spline. A set of elevations in one direction is used to illustrate a point that large transitions in elevation influence the coefficients in the polynomial fit and contribute spectral energy to points far from the transition area. It argues that a linear interpolation process, or a cubic spline interpolation, would be more appropriate.
USE OF ALBENDAZOLE IN FEED TO CONTROL FASCIOLOIDES MAGNA INFECTIONS IN CAPTIVE WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) (1990)

Thirty-six adult white-tailed deer (Odocoileus virginianus) naturally infected with Fascioloides magna were captured and randomly assigned to four groups. Each group was fed pelleted feed coated with albendazole for each of seven consecutive days to deliver the drug at a dose rate of approximately 0.0, 5.0, 8.5, or 16.5 mg/kg bodyweight/day. At 7 wk posttreatment, each animal was euthanized and necropsied. Effects of albendazole treatment included significant reduction (P less than 0.05) in parasite egg count per gram of feces and increase in serum albumin concentration (P less than 0.05). Smaller parasites or remains of dead parasites were seen at the end of migratory tracks in the treated groups. Efficacy of the drug was 82 to 84%.
The Isolated Perfused Lung Preparation (2018)

The extensive popularity of the isolated perfused lung preparation stems from the ease with which the preparation can be established, as also to the variety of data that can be obtained. Among the experimental preparations used to investigate the pathophysiology of pulmonary edema, one of the most popular is the isolated, perfused lung. The unique advantages of this preparation are that blood flow, vascular pressures, and the extent of fluid accumulation can all be accurately determined. In general, the isolated dog lung responds sluggishly to vasoconstrictors. For instance, hypoxic vasoconstriction cannot be elicited in the isolated dog lung. The circuit resembles that for constant flow perfusion, except that the blood is pumped into an arterial reservoir proximal to the bubble trap. The isolated perfused lung is particularly useful for the determination of the lung microvascular filtration rate. For micropuncture, the isolated lobe is held at a constant inflation pressure. Therefore, an exact quantitation of lung microvascular liquid exchange is possible.
The effects of auditory perception and musical preference on anxiety in naive human subjects. (2003)

Students participating in the study already had knowledge of what genre of music would best relax them. It is our belief, that within the general population, many people do not have this self understanding. We conclude that music therapy may provide a mechanism for this self-understanding and subsequently help alleviate anxiety and stress.
Lack of modulation ofMDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant mcf-7 breast cancer cells (1999)

The drug transporter P-glycoprotein (P-gp) appears to play an important role in the ability of tumor cells to evade killing by chemotherapeutic agents. Using pharmacological inhibitors of cAMP-dependent protein kinase (PKA), it has been suggested that, similar to rodent model systems, the human P-gp gene (MDR1) is also under PKA-dependent control and that PKA inhibition may prove useful in reducing drug resistance in human cancer cells. To test this hypothesis, we stably transformed doxorubicin (Adriamycin)-resistant human MCF-7 breast cancer cells (MCF-7(ADR)) with a vector that inhibits PKA activity by inducing over-expression of mutant type Ialpha PKA regulatory (RIalpha) subunits. Two transformants (MCF-7(ADR-A) and MCF-7(ADR-B)) were found to express mutant RIalpha subunits and to possess markedly reduced PKA activity; another transformant (MCF-7(ADR-9)) lacked mutant RIalpha subunit expression and exhibited no inhibition of PKA activity. In contrast with findings in Chinese hamster ovary and Y1 adrenal cells, P-gp levels and cellular sensitivity to drugs which are P-gp substrates were unchanged in the PKA-inhibited transformants, suggesting that P-gp expression and function are not under PKA-dependent control in MCF-7(ADR) cells. Growth and saturation densities of the cell lines were highly correlated with level of PKA catalytic activity, suggesting that PKA inhibition may prove useful in inhibiting growth of breast tumor cells, even upon establishment of resistance to doxorubicin. However, our results challenge current proposals that drug sensitivity in P-gp-expressing human tumor cells may be restored by blocking MDR1 gene expression through inhibition of PKA activity.
Effects of Womersely and Reynolds Numbers on a Symmetric Compliant Bifurcation (2002)

Twelve million people worldwide die of diseases associated with atherosclerosis. It is estimated that atherosclerosis costs the US economy 100 billion dollars each year. From clinical studies, it is well known that atherosclerosis has preferred locations in the vascular system, primarily sited in the carotid arteries, coronary arteries, and in vessels supplying the lower extremities in the arterial system [1]. In the vicinity of a bifurcating, arterial flow tends to separate forming recirculation regions. In addition, due to the pulsatile character of blood flow during the deceleration part of the cycle, the flow becomes unstable and transition to turbulence may occur. The combination of the above-described phenomena generates abnormal shear stress levels and high shear stress gradients, especially at the reattachment point of the separated region.
CD SEM calibration to TEM for accurate metrology of fins in MuGFET devices (2005)

We describe a procedure to calibrate CD SEM to TEM for accuracy. This goal is achieved by using 4 CD reference standards in the range 10-70 nm. After calibration, the CD SEM demonstrated sensitivity to process variation down to 10 nm. The accuracy of the CD SEM measurements on fins of MuGFET devices was confirmed by TEM analysis.
Infra-red and Raman spectra of dimeric gallium trihalides (1966)

The infra-red spectra of dimeric gallium trichloride, tribromide and tri-iodide have been recorded in the range 50–800 cm–1. These results, in conjunction with the Raman spectra and polarzation measurements on the trichloride and tribromide, are consistent with a bridged (D2h) dimeric molecular unit in the solid and liquid phases, and the spectra have been analyzed accordingly; analogies with these spectra make possible a partial assignment of the infra-red-active fundamentals of gallium tri-iodide.
Status of Performance of Thin Film Silicon Solar Cells and Modules (2008)

SCHOTT Solar Thin Film has successfully scaled up its production technology for a-Si/a-Si tandem cells from 0.6 m² to 1.4 m² (Gen 5) module size in Jena. The Jena fab with a capacity of 33MW/a started production in late 2007 and ramp up was completed in mid 2008. While small area R&D cells deposited in a large area PECVD tool achieve 10.4 % initial efficiency, the best module yields 123 W initial power which corresponds to 9.1 % initial aperture efficiency. Light induced degradation of a 1.4 m² module is demonstrated to be only 16.3%. Thus, more than 100 W stabilized power can be projected. The ASITM module design takes PV-system requirements into consideration. The low voltage module design with high maximum system voltage allows high power per PV-string, comparable to c-Si based PV-installations. ASITM modules submitted to damp heat after 14 years outdoor exposure do not reveal any power losses, thus demonstrating high reliability and long-term durability. During summer, a small PV-system based on ASITM 95W modules yields remarkable performance ratios higher than 90%, compared with 80% for the c-Si based reference system.
Low-Temperature, Low-Pressure Transport Coefficients for Gaseous Oxygen and Sulfur Atoms (1959)

The transport properties of a gas at low temperature can be estimated in terms of the potential energy curves at very large separations. For this purpose it is only necessary to know the dispersion and multipole energies of interaction. Such calculations are carried out for the interaction of two oxygen or two sulfur atoms in their ground states. The atoms have an a priori probability pi of interacting in accordance with one of a set of potential energy functions Φi(R), where pi is proportional to the sum of the degeneracies of the states of the collision complex to which Φi(R) applies. For such collisional problems involving more than one potential energy function, the collision cross section Q for any process is rigorously additive in the sense that Q = ΣipiQi, where Qi is the collision cross section considering only the ith potential.
The bromoquinone annulation reaction: a formal total synthesis of EO9 (2003)

The following report describes a one-pot regiospecific annulation reaction in the production of a highly advanced EO9 precursor. This intermediate is modified in what constitutes the shortest total synthesis of the EO9 antitumor drug.
Obesity and Systemic Oxidative Stress (2003)

Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF2alpha levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease.
Polyhydroxylated Steroidal Saponins from the Rhizomes of <i>Convallaria majalis</i> (2007)

Six new polyhydroxylated spirostanol saponins (1–6) were isolated from the methanolic extract of the rhizomes of Convallaria majalis. On the basis of extensive spectroscopic analysis, including 2D NMR data, and a few chemical transformations, the structures of 1–6 were determined to be 1β,2β,3β-trihydroxy-5β-spirost-25(27)-en-5-yl β-D-galactopyranoside (1), (25 S)-1β,2β,3β-trihydroxy-5β-spirostan-5-yl β-D-galactopyranoside (2), 1β,2β,3β,4β-tetrahydroxy-5β-spirost-25(27)-en-5-yl β-D-galactopyranoside (3), (25 S)-1β,2β,3β,4β-tetrahydroxy-5β-spirostan-5-yl β-D-galactopyranoside (4), 1β,2β,3β,4β-tetrahydroxyspirost-25(27)-en-5-yl α-L-arabinopyranoside (5), and (25 S)-1β,2β,3β,4β-tetrahydroxy-5β-spirostan-5-yl α-L-arabinopyranoside (6), respectively.
Anions as Bridging and Non-bridging Ligands in Reactions of Co(III) Compounds with Cr<sup>++</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnions as Bridging and Non-bridging Ligands in Reactions of Co(III) Compounds with Cr++Henry TaubeCite this: J. Am. Chem. Soc. 1955, 77, 17, 4481–4484Publication Date (Print):September 1, 1955Publication History Published online1 May 2002Published inissue 1 September 1955https://pubs.acs.org/doi/10.1021/ja01622a010https://doi.org/10.1021/ja01622a010research-articleACS PublicationsRequest reuse permissionsArticle Views212Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Monolithic integrated microgratings and photodiodes for wavelength demultiplexing (1982)

The monolithic integration of micrograting filters and a photodetector array on a silicon substrate for optical wavelength demultiplexing is demonstrated. The demultiplexer is constructed with a series of micrograting filters fabricated by the electron beam direct writing technique in a chalcogenide (amorphous As2S3) film waveguide on a thermally oxidized silicon substrate and a Schottky barrier photodiode array fabricated on the Si surface.The device has the advantages of a high degree of design flexibility, high efficiency, low crosstalk, and very small dimensions. The design considerations and the fabrication process are described and the experimental results are discussed on the demultiplexing characteristics.
Several Mechanical Manipulations of the Wall of the Inner Ear Do Not Affect Air and Bone Conduction Auditory Thresholds (2011)

It is likely that an alternative mode of cochlear excitation is possible.
A Real Time Window-Based Local Call Admission Control Algorithm for IP Networks (2011)

We propose and evaluate a real-time window-based local call admission control algorithm (RWBLAC) for achieving quality of service in IP networks. RWBLAC utilizes a real time traffic measurement and variation of window based techniques traffic policing for QoS admission decisions. This real time fashion based on actual arrival rate make this research distinct form all other using predefined threshold. We use simulation to evaluate the link utilization and adherence to service commitment that could be achieved by RWBLAC, and to compare the performance of its diverse implementation options.
Localized Corrosion Growth Kinetics in AA2024 Alloys (2002)

The kinetics of localized corrosion in AA2024 alloys were studied using the foil penetration technique. The growth kinetics for localized corrosion in AA2024-T3 exhibited a strong anisotropy, being slower in the short transverse or plate through-thickness direction than in either the longitudinal or long transverse directions. This growth rate anisotropy depended on the grain size and aspect ratio, and was different for different forms of AA2024-T3. The attack was primarily intergranular corrosion (IGC) at potentials of −610 mV SCE and higher in 1 M NaCl. The IGC growth rate was almost independent of potential over the range from −610 to +500 mV SCE, which suggests that only a small amount of the anodic dissolution current at the active IGC tip escapes from the IGC crevice. At lower potentials the attack was pit-like, and the rate of growth decreased with decreasing potential. Artificial aging of AA2024 to the T8 temper changed the attack from sharp IGC to selective grain dissolution, but the growth kinetics at high potentials were not strongly affected. The addition of nitrate increased the breakdown potential, and therefore decreased the growth kinetics in that region. At high potential, the nitrate had no effect. Sulfate addition had no significant effect at any potential studied.
SECTION II ARTHROPODS LISTED BY COMMON NAME (1987)

The One-Off Title series, published from 1969 to 1991, is a collection of 13 titles that nicely support and augment the Entomological Society of America's other collections. It comprises a mix of annotated bibliographies, species overviews, indexes and thesaurus, resource guides, and crop and pest management titles.
Reactive Synthesis and Phase Stability Investigations in the Aluminum Nitride–Silicon Carbide System (2000)

The effect of AlN on the structure formation of SiC was investigated. SiC was synthesized in the presence of AlN under vacuum at 1500°C, and the result was cubic SiC. The synthesis of AlN–SiC composites through the reaction Si 3 N 4 + 4Al + 3C = 3SiC + 4AlN was also investigated and compared with synthesis via field‐activated self‐propagating combustion (FASHS). Reactants were heated in a vacuum furnace at temperatures ranging from 1130° to 1650°C. Below 1650°C, the reaction is not complete and at this temperature the product phases are AlN and cubic SiC. At 1650°C, the product contained an outer layer which contained β‐SiC only and an inner region which contained AlN and cubic SiC. 2H‐SiC and AlN composites synthesized via field‐activated self‐propagating combustion were annealed at 1700°C under vacuum. The AlN dissociated and evaporated and the 2H‐SiC transformed to the cubic β phase. Reasons for the differences in products of furnace heating and FASHS are discussed.
Effect of Heat Treatment on Photoconductivity and Electrophotographic Properties of Lead Monoxide (1982)

The effect of heat treatment on the photosensitivity and electrophotographic properties of lead monoxide powder has been investigated. There appears to be a critical temperature of annealing at which photosensitivity is maximum and the darkconductivity is minimum. The electrophotographic behaviour characterized by acceptance potential, dark discharge rate, contrast potential, etc. improved considerably on thermal treatment. The results have been explained mainly on the basis of barrier layer formation at the intergranular sites.
Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons (1990)

1. Voltage-clamp experiments were used to study N-methyl-D-aspartic acid (NMDA) receptor antagonists applied by fast perfusion to mouse hippocampal neurons in dissociated culture. 2. Preincubation with the NMDA antagonists zinc (3-30 microM) and magnesium (30-300 microM) reduced subsequent responses to 100 microM NMDA applied together with these antagonists. No time dependence of antagonism was observed when responses were measured at the start and at the end of NMDA pulses 1.25-1.5 s in duration. 3. Two competitive antagonists of similar affinity in equilibrium experiments, D-2-amino-5-phosphonopentanoic acid (D-AP5) and 3-((+-)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), had different profiles of action when applied as described above. With D-AP5, pulses of NMDA produced fast-on, fast-off responses, of reduced amplitude, similar to the effect of Zn and Mg. Responses to NMDA in the presence of CPP were also of reduced amplitude but, in addition, showed slow activation, such that the antagonist action of CPP decreased with time after the application of NMDA. 4. In the presence of 3 microM glycine and NMDA receptor antagonists with activity at the glycine modulatory site, either kynurenic acid (Kyn), 7-chlorokynurenic acid (7Cl-Kyn), or 5-chloro-indole-2-carboxylic acid (5Cl-I2CA), NMDA-evoked responses showed apparent use-dependent antagonism, such that the peak response to NMDA was much greater than the equilibrium response. A similar effect was produced by preincubation with low concentrations of glycine (less than 300 nM), which enhances desensitization of responses to NMDA. The apparent use-dependent action of glycine antagonists could be reversed on raising the glycine concentration and did not vary appreciably with changes in membrane potential over the range -60 to +50 mV. 5. Concentration-jump application of NMDA antagonists, in the presence of 100 microM NMDA and 3 microM glycine, were used to study antagonist association and dissociation kinetics directly. For D-AP5 and CPP, the dissociation rate was independent of antagonist concentration, and approximately 15 times faster for D-AP5 (19.6 s-1) than for CPP (1.36 s-1). The association rate for D-AP5 and CPP increased with antagonist concentration in a linear manner over the range 3-30 microM and was slower for CPP than for D-AP5, consistent with their similar potency at equilibrium. 6. In contrast to results obtained with CPP and D-AP5, the association rate for 7Cl-Kyn was approximately 3 times slower than the dissociation rate and did not change with concentration of antagonist.(ABSTRACT TRUNCATED AT 400 WORDS)
Synthesis and Absolute Configuration of (<i>S</i>)-(−)- and (<i>R</i>)-(+)-2,3-Dihydro-2-(1-methylethenyl)-6-methoxybenzofuran (1999)

Resolution of racemic 2,3-dihydro-2-carboxy-6-methoxybenzofuran (2) by recrystallizations of diastereomeric salts prepared with (S)-(-)-alpha-methylbenzylamine and (R)-(+)-alpha-methylbenzylamine gave the starting materials for the four-step total syntheses of (S)-(-)-2,3-dihydro-2-(1-methylethenyl)-6-methoxybenzofuran (1a) and (R)-(+)-2,3-dihydro-2-(1-methylethenyl)-6-methoxybenzofuran (1b). Their absolute configuration was established by chemical correlation.
Measurement of Inductive Coupling Effect on Timing in 90nm Global Interconnects (2006)

Inductive coupling is becoming a design concern for global interconnects in nano-meter technology. This paper shows measurement results of inductive coupling effect on timing, and reveals that inductive coupling noise is a practical design issue in 90nm technology. The measured delay change curve is consistent with circuit simulation results with RLC interconnect model, and definitely different from those of conventional RC model. Long-range effect and noise reduction by ground insertion are clearly observed on silicon
Age- and Site-Specific Variation in the Dermoscopic Patterns of Congenital Melanocytic Nevi (2007)

Our results suggest that the predominant dermoscopic patterns of CMN vary according to age and lesional site. These differences may inform future studies on the pathogenesis of CMN.