gebhart/patrepeval huggingface dataset:
Board 150:Product Life-cycle Management Scholarship Program (2020)

Abstract The Product Lifecycle Management (PLM) Scholarship Program is supported by a National Science Foundation Scholarships in STEM (S-STEM) grant (#1060160). The goal of the program is provide academically sound, but financially challenged, students with the means to enroll as full-time students at Oakland University in the fields of Industrial and Systems Engineering, Mechanical Engineering or Electrical Engineering with the expectation that a successful student will receive a baccalaureate degree within four years and will, upon graduation, be capable of entering the high technology workforce or continuing their education at the graduate level. A unique aspect of the PLM Scholarship program involves investigators working with several companies to identify paid engineering internship opportunities (both summer and year-round) for the students. A majority of the students were placed into such internships. The investigators received assistance on identifying some internship opportunities from Oakland University's Pawley Lean Institute. Over 20 companies hired PLM Scholarship students to these internship positions. The investigators also worked closely with the university's Career Services Office to prepare students for these internships (develop resumes and cover letters, mock interviews, etc.). Seventeen of the PLM Scholarship students have graduated to-date with a B.S. in Engineering degree. All graduates obtained full-time engineering positions upon graduation or entered graduate school.
A case of epithelioid hemangioendothelioma of the liver followed by repeated surgical resection. (1996)

肝葉切除後33ヵ月で残肝再発をきたし,再切除しえた肝原発類上皮型血管内皮腫Epithelioid Hemangioendothelioma (EHE)の1例を経験した.症例は57歳・女性で胆摘施行時に肝腫瘍を発見,当科にて肝右葉切除およびS4部分切除術をおこない,EHEの確診をえた.経過観察中に再発を認め,肝S3, S4部分切除術を施行し,術後5-FU,塩酸エピルビシンの肝動注療法を併用した.肝原発EHEは本邦報告が28例に過ぎない非常にまれな疾患である.組織発生については不明な点も多いが,著者らは切除標本から腫瘍培養細胞株を樹立し,腫瘍の発生・線維化における伊東細胞の関与について検討した.本腫瘍の治療体系は末だ確立されておらず切除例も少ないが,本症例は再切除後24ヵ月を経過した現在,再発・転移等の徴候はなく,比較的早期の肝EHEに対しては,積極的な外科的切除と動注化学療法の併用が効果的と考えられた.
Adding backbone to protein folding: why proteins are polypeptides (1996)

It is argued that the chemical nature of the polypeptide backbone is the central determinant of the three-dimensional structures of proteins. The requirement that buried polar groups form intramolecular hydrogen bonds limits the fold of the backbone to the well known units of secondary structure while the amino acid sequence chooses among the set of conformations available to the backbone. 'Sidechain-only' models, based for example on hydrophobicity patterns, fail to account for the properties of the backbone and thus will have difficulty capturing essential features of a folding pathway. This is evident from the incorrect predictions they make for the conformations of the limiting cases of all-hydrophobic or all-polar sequences.
Crystal Structure of the Haloalkane Dehalogenase from<i>Sphingomonas paucimobilis</i>UT26<sup>,</sup> (2000)

The haloalkane dehalogenase from Sphingomonas paucimobilis UT26 (LinB) is the enzyme involved in the degradation of the important environmental pollutant gamma-hexachlorocyclohexane. The enzyme hydrolyzes a broad range of halogenated cyclic and aliphatic compounds. Here, we present the 1.58 A crystal structure of LinB and the 2.0 A structure of LinB with 1,3-propanediol, a product of debromination of 1,3-dibromopropane, in the active site of the enzyme. The enzyme belongs to the alpha/beta hydrolase family and contains a catalytic triad (Asp108, His272, and Glu132) in the lipase-like topological arrangement previously proposed from mutagenesis experiments. The LinB structure was compared with the structures of haloalkane dehalogenase from Xanthobacter autotrophicus GJ10 and from Rhodococcus sp. and the structural features involved in the adaptation toward xenobiotic substrates were identified. The arrangement and composition of the alpha-helices in the cap domain results in the differences in the size and shape of the active-site cavity and the entrance tunnel. This is the major determinant of the substrate specificity of this haloalkane dehalogenase.
In Reply to Corbridge and to Schattner (2016)

The questions raised by Dr. Schattner and Dr. Corbridge resonate with our intentions for our study and are reflective of the kind of discussion we hoped to inspire in the medical community. Our reason for publishing our study in Academic Medicine was to bring the results back to those practicing medicine and mentoring new genera tions of physicians as an opportunity for reflection. As the authors point out in their letters, our results are consistent with the results of similar studies, suggesting that the findings may be consistent across industry. We do acknowledge, however, that residents may have more direct patient contact in other rotations, such as during outpatient care. We also emphasize the importance of deep observational studies such as ours that complement larger surveys. Our methods allowed us to examine residents’ activities with a great level of detail. As informaticians, our overarching goal is in identifying new ways to inform and improve health care delivery with new tools and solutions, and to continue to improve upon solutions developed thus far. For example, our study not only suggested that the residents spent over 50% of their time using computers but also helped to identify specific instances when this use was less than efficient. Some of these inefficiencies have already been addressed by concrete changes to the design of our electronic health record and its usage practices in our institution. There is an urgent need for continuing critical examination of clinical work practices and the tools that clinicians increasingly rely on and for bringing the results of such studies to the attention of the medical community. Lena Mamykina, PhDAssistant professor, Department of Biomedical Informatics, Columbia University, New York, New York; [email protected] David Vawdrey, PhDAssistant professor, Department of Biomedical Informatics, Columbia University, and vice president, Value Institute of NewYork-Presbyterian Hospital, New York, New York. George Hripcsak, MD, MAChair and Vivian Beaumont Allen Professor of Biomedical Informatics, and director, Medical Informatics Services, NewYork-Presbyterian Hospital, New York, New York.
A New Synthesis of 1,4-Diaryl-1,3-butadienes Utilizing the Anil Synthesis (1990)

The anil synthesis was employed in the preparation of 1,4-diarylsubstituted 1,3-butadienes 7 from 1-arylpropenes 5 and N- arylideneanilines (aromatic Schiff bases) 6 in dimethylformamide solution and a strong base as catalyst obtained in situ by reacting metallic sodium with this solvent.
<title>System demonstrator for board-to-board-level substrate-guided wave optoelectronic interconnections</title> (2001)

We design and implement a system demonstrator based on vertical-cavity surface-emitting lasers, polymeric hologram grating couplers, and metal-semiconductor-metal photodetectors. As a preliminary experiment, we show the feasibility of board-to-board level substrate-guided wave optoelectronic interconnections in the real electrical system. First, we introduce a new architecture--centralized optical backplane--for board-to-board level interconnections. Second, the optoelectronic data channel is constructed compatible with standard PECL and capable of operating a 1.25 Gbps. Finally, it is employed to replace the conventional electrical data channel in a microprocessor system. We describe the performance of the entire system and discuss the future application of our centralized optical backplane in other electrical systems.
Gentile of Foligno Interprets the Prophecy “Woe to the World,” with an Edition and English Translation (2001)

If a diary of a prominent late-medieval religious figure were to be discovered that revealed his thoughts about the present and the future, such a discovery would seem to be too good to be true. But if labeled differently, such a document does exist: not a diary, but a prophetic commentary. The commentary by the fourteenth-century Augustinian friar Gentile of Foligno on the prophecy “Ve mundo in centum annis,” has never been the subject of sustained attention. Consequently the following presentation aims to examine it carefully within the context of the author's career and to show how it reveals some intriguing working habits as well as Gentile's firm hopes for the advent of angelic popes and ecclesiastical renewal.
Increasing Software Reliability through ollback and On-line Fault (1997)

In this papec we propose a new paradigm for increasing the reliability of a software system by combining reactive and proactive approaches. The proposed approach employs rollback and restart for masking transient failures, and employs on-line software version change to remove faults from the software. A model for reliability analysis of a system employing the proposed approach is presented. The analysis shows that substantial benefit in reliability can be obtained by employing the proposed approach. A prototype system which incorporates the proposed approach is also described.
Intra-cavity frequency doubling of a Nd:YAG laser passively Q-switched by Cr/sup 4+/:YAG saturable absorber (2001)

Summary form only given. We report a diode-pumped Nd:YAG laser which was passively Q-switched by a Cr/sup 4+/:YAG saturable absorber (SA), and intra-cavity frequency doubled by a LiB/sub 3/O/sub 5/ crystal. The maximum green average power was 1.0 W, with the laser operating at 3.8 kHz repetition frequency.
A new method for the evaluation of biological activity in pharmaceutical and cosmetic raw materials. (2000)

The aim of research is today to study alternative methodologies for substituting in vivo tests: we propose in the present work a new method for the in vitro evaluation of biological activity in pharmaceutical and cosmetic raw materials. The parameters considered were necrosis contra apoptosis. We carried out our experiments on HL60 cell, a good model for highlighting all apoptotic markers.
Ethanol-mediated regulation of transcription factors in immunocompetent cells (2002)

The immunomodulatory effects of acute and chronic alcohol use are characterized by impaired antigen-specific immune activation and by increased susceptibility to infections due to alterations in innate immune responses and inflammatory mediator production. The central feature of cellular responses to inflammatory and stress signals is the activation of the nuclear regulatory kappa B/Rel family of transcriptional factors via various surface receptor systems in immunocompetent cells. Activation of NF-kappa B, however, is regulated at multiple levels including I-kappa B degradation, nuclear translocation, and by interaction of NF-kappa B/Rel with other transcription factors. Data from our and other laboratories demonstrate that acute alcohol treatment inhibits activation and nuclear binding of the p65/p50 NF-kappa B functional heterodimer in human monocytes, a mechanism likely contributing to inhibition of pro-inflammatory cytokine production. Here we show that acute alcohol-mediated inhibition of NF-kappa B activation in various monocytic cells including human monocytes and murine macrophages. Inhibition of NF-kappa B activation by alcohol in monocytic cells was independent of I-kappa B alpha degradation. These acute-alcohol-induced changes in monocytic cells were different compared to T lymphocytes, both in Jurkat CD4 cells and peripheral human T cells, acute alcohol had a biphasic effect on TNF-alpha-induced NF-kappa B activation via an I-kappa B alpha-dependent mechanism. Inhibition of NF-kappa B activation by acute alcohol in LPS-activated human monocytes was associated with an increase in nuclear glucocorticoid receptor (GR) levels and reduced GR binding to the glucocorticoid response element (GRE). Together these findings support the hypothesis that in the presence of alcohol, nuclear interaction of NF-kappa B (p65) with glucocorticoid receptor and/or other transcription factors may contribute to the reduced NF-kappa B activation. In contrast to the inhibitory effects of acute alcohol on NF-kappa B activation in monocytic cells, chronic alcohol use and alcoholic hepatitis result in an augmentation of NF-kappa B activation and pro-inflammatory cytokine induction. These results suggest that the complex interactions of the NF-kappa B/Rel and related transcription factors including GR and heat-shock responses determine the level of activation of the immunocompetent cells in response to the challenge of acute and chronic alcohol use at the single cell level.
Comparing piezoelectric and coreless electromagnetic transformer approaches in IGBT driver (2006)

Gate drive circuits for power MOSFET's and IGBT's often require electrical insulation. Different methods of electrical insulation can be used: bootstrap circuits, transformers and optic couplers. It has been proved that Piezoelectric transformer (PT) exhibit suitable characteristics, good integration capability and can be used for both power and signal transfer in low power applications. However, coreless planar electromagnetic transformer (CT) technology is an alternative solution that can also give satisfactory results. This paper compares the performances and the capabilities of integration of these two kinds of transformers (i.e. PT vs. CT). The study and comparisons are carried out in a two-gate driver, functioning in a half-bridge inverter. The two devices have the same structure, similar electric characteristics (operating at resonance frequency in both cases), identical electric values and the dimensions of the two transformers are quite the same. Additionally, some EMI aspects regarding the use of these transformers will be considered.
Changes in Colorectal Cancer Care in Japan before and after Guideline Publication: A Nationwide Survey about D3 Lymph Node Dissection and Adjuvant Chemotherapy (2014)

D3 dissection for stage II to III disease and adjuvant chemotherapy for stage III disease have become more prevalent and the variation in performance among institutions has decreased in the last decade. Importantly, publication of the guidelines has accelerated the spread of surgical standards.
Case Report of Spontaneous, Nonspinal Fractures in a Multiple Myeloma Patient on Long-term Pamidronate and Zoledronic Acid (2008)

Pamidronate and zoledronic acid are two potent intravenous bisphosphonates used in the treatment of multiple myeloma as well as osteoporosis. While the concern for heightened fracture risk in a patient on long-term bisphosphonate treatment for malignancy has been previously noted, we present the first case of spontaneous, nonspinal fractures in a patient undergoing treatment for multiple myeloma. The patient had a positive 9-year history of bisphosphonate treatment and presented with sequential subtrochanteric stress fractures of the left and right femurs. Pathological reports of fracture site biopsies demonstrate signs consistent with ametabolic bone and no malignancy. These findings point to extreme inhibition of bone turnover by bisphosphonates as the cause of this patient's morbidity. This is a single retrospective case study (level IV evidence).
Tools for MHD simulation of hot dense plasma (2002)

The complexity of physical problems in plasma demands special tools for its analysis. The primary source of data is, of coarse, the physical experiment. But, sufficiently complete comprehension of physical phenomenon is actually impossible without the numerical simulation, which is more and more often named as computational experiment. Moreover, computational experiment usually provides more complete set of data, which becomes credible only after verification by experiment. The processes under consideration (such as different Z-pinches, plasma opening switches-POS, plasma focus and others) have some common features. Fist of all, they are non-stationary and subjected to divers instabilities. Another common feature is a big difference in time and spatial scales, and small local details are very often significant for global process development. This means, that some kind of adaptation is inevitable for numerical simulations. Traditional lagrangian approach can be also considered as adaptation, based on the mass, but it is not applicable to the problems with high level of convection or mixing. Two numerical methods for MHD plasma simulation and corresponding codes are presented here. The first code ASTRE uses original adaptive mesh refinement algorithm, the other one, Z+ is based on classical arbitrary lagrangian-eulerian algorithm. These two approaches are complimentary. Each of them has its own advantages and specific application domains, but each of them covers the majority of the problems under consideration.
The interrelationship of Plasmodium falciparum and P. vivax in the Punjab (1989)

Analysis of data obtained from Giemsa-stained blood films from patients with mixed Plasmodium vivax and P. falciparum parasitaemias seen in outpatient clinics held over 20 consecutive months in 4 villages in the Pakistani Punjab suggest that infections with P. falciparum and P. vivax were independent of each other. There was no evidence to support the hypothesis that P. falciparum suppressed P. vivax. A likely explanation for the seasonal variation in species parasitaemia rates in the Punjab is that P. vivax was predominant early in the transmission season due to late relapses, while P. falciparum was predominant later in the transmission season because of community-wide development of immunity to P. vivax.
[Presence of radioactivity in the gastric juice of dogs after the intracardiac injection of 3H-or 35S-labeled heparin]. (1983)

The presence of radioactivity has been observed in the gastric juice of Dogs which received an intra-cardiac injection of radioactive heparin and were undergoing extra-corporeal circulation with the heart at rest and the lungs by-passed.
EFFECT OF CYCLOSPORINE ON PLASMA LIPIDS AND MODIFICATION WITH DIETARY FISH OIL (1988)

Hyperlipidemia is an identified risk factor for atherosclerosis in patients following renal transplantation that may be related to previous uremia and various drugs including steroids. Recent evidence has suggested that treatment with cyclosporine may be an independent risk factor for development of hyperlipidemia in some patients. Twenty-four Sprague Dawley rats were given CsA at 30 mg/kg by gavage for 28 days in 1 ml of olive oil or fish oil vehicle, and compared with controls receiving just vehicle. Increases of both triglyceride (233.6%) and cholesterol (50.9%) were observed in olive oil/CsA animals (P less than .01), with no significant change noted with either vehicle alone. An increase of triglyceride from baseline was observed with fish oil/CsA (119%) (P less than .01) but was significantly less than the increase with olive oil/CsA animals (P less than .05). No increase in cholesterol was found in CsA-treated rats using the fish oil vehicle. The mechanisms leading to hyperlipidemia with four weeks of CsA administration in these rats are unknown, but may be related to altered hepatic synthesis. CsA levels were lower in fish oil-treated animals, possibly explaining the difference noted in lipid levels--or, alternatively, reduction of plasma lipoproteins may have altered drug kinetics and CsA binding. This work emphasizes a need for further study of lipids in CsA-treated patients, and advises some caution in the use of lipoprotein-reducing agents in patients using CsA without consideration of the possible effect on free drug levels.
Generation of 356 W peak power from all-semiconductor master oscillator power amplifier (MOPA) system based on extreme chirped pulse amplification (X-CPA) concept (2005)

Based on the X-CPA concept, to authors' knowledge, we demonstrate the generation of a 356 W record peak power from all-semiconductor mode-locked MOPA system implemented with chirped fiber Bragg grating as an extreme pulse stretcher and compressor.
Diff use coronary disease: short- and long-term outcome after percutaneous coronary intervention (2013)

Atherosclerotic involvement of small vessels in patients with CAD confers a higher short- and long-term risk of adverse outcome after PCI.
Sexual Attitudes and Behavior of Female Readers and Non-Readers of Erotic Literature (1979)

50 female students in a church-related college were surveyed to determine the association of selected sexual attitudes and behaviors and reading habits related to erotic literature. Reading habits did not appear to influence sexual behavior or attitudes toward oral-genital sex.
Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity (2020)

The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent strain, NZB or NZW, has limited autoimmunity, suggesting traits of both strains contribute to pathogenesis. Although many of the contributing genes have been identified, the contributing cellular abnormality associated with each parent strain remains unresolved. Given that plasmacytoid dendritic cells (pDCs) are key to the pathogenesis of lupus, we investigated the properties of pDCs from NZB and NZW mice. We found that NZB mouse had higher numbers of pDCs, with much of the increase being contributed by a more abundant CD8<sup>+</sup> pDC subset. This was associated with prolonged survival and stronger proliferation of CD4<sup>+</sup> T cells. By contrast, NZW pDCs had heightened capacity to produce interferon-α (IFNα) and IFNλ, and promoted stronger B-cell proliferation upon CpG stimulation. Thus, our data reveal the different functional and numerical characteristics of pDCs from NZW and NZB mouse.
Synthesis and Characterization of One-Component Polymeric Photoinitiator by Simultaneous Double Click Reactions and Its Use in Photoinduced Free Radical Polymerization (2009)

A polystyrene copolymer (PS-B-DMAB) possessing both benzophenone and dimethylamino moieties in the side chain was synthesized by a combination of nitroxide-mediated radical polymerization (NMRP) and simultaneous double “click” reactions. First, a random copolymer of styrene (S) and chloromethylstyrene (CMS) with 32 mol % CMS content was prepared by NMRP process. Then, chloromethyl groups were converted to azide groups by reacting with NaN3 in DMF. The other two click components, namely, propargyl benzophenone (Pr-B) and propargyl 4-(dimethylamino)benzoate (Pr-DMAB), were prepared independently by the etherification and esterification reactions, respectively. Then, in the final stage, the obtained alkyne functional chromophoric (Pr-B) and hydrogen-donating (Pr-DMAB) molecules were anchored to azide-modified polystyrene (PS-N3) in one-step by “click chemistry”. The final polymer (PS-B-DMAB) and the intermediates were characterized in detail by spectral analysis and laser flash photolysis studies. The resulting polymer possesses absorption characteristics similar to bare bezophenone. The one-component photoinitiating nature of PS-B-DMAB was demonstrated by photopolymerization of mono- and multifunctional monomers, namely, methyl methacrylate (MMA) and trimethylolpropane triacrylate (TMPTA), respectively.