gebhart/patrepeval huggingface dataset:
Use of a specific oral hyposensitization therapy to Dermatophagoides pteronyssinus in children with atopic dermatitis. (1994)

The aim of the present study was to evaluate the efficacy of an oral specific hyposensitization therapy in children with atopic dermatitis and positive prick skin tests and/or RAST to Dermatophagoides pteronyssinus (D.pt.). A total of 60 patients, in three different clinical groups, were selected for a three years clinical trial. Group A: children with atopic dermatitis and allergic asthma and/or rhinitis; groups B and C: children with exclusively atopic dermatitis. Groups A and B received specific hyposensitization therapy. Group C was the control group. The clinical evaluation of the dermatological lesions, at the end of our study, didn't show any significant difference among the three groups. Moreover, the onset of respiratory symptoms between the two groups with exclusively atopic dermatitis was similar and not related to the positivity of prick skin tests and/or RAST to seasonal allergens. Our study suggests that specific hyposensitisation therapy with extracts of D.pt., although with no side effects, does not affect the natural history of atopic dermatitis.
A Homozygous Splice Mutation in the<i>HSF4</i>Gene Is Associated with an Autosomal Recessive Congenital Cataract (2004)

This is the first report describing association of an autosomal recessive cataract with the HSF4 locus on 16q21-q22.1 and the first description of HSF4 splice variants in the lens showing that HSF4b is the major transcript.
A fast lattice-based approach to vocabulary independent wordspotting (2002)

Practical applications of wordspotting, such as spoken message retrieval and browsing, require the ability to process large amounts of speech data at speeds many times faster than real-time. The paper presents a novel approach to this problem in which all of the stored audio material is preprocessed off-line to generate a phoneme lattice. At search time, putative word matches are found in this lattice using symmetric dynamic programming. The paper presents the details of the algorithms used and compares performance with a number of conventional approaches using a 20 keyword vocabulary on the DARPA Resource Management Task. The results show that the proposed method is very much faster yet performs acceptably compared to conventional systems which depend on keyword-specific training or prior knowledge of the test set vocabulary.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Microcontroller compatible clock chip design using field programmable gate array (1991)

The design and implementation of a microcontroller-compatible real-time clock using a field programmable gate array are presented. The advantage of rapidly prototyping an IC chip design according to user-defined specifications is demonstrated. The chip design is directly interfaced with 10 seven-segment light-emitting diodes for displaying time and calendar information. Translating the clock function to an external peripheral allows the microcontroller to perform other tasks more efficiently. The relatively short cycle time to develop a product from concept to the final chip is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Long-distance continuous-variable quantum key distribution with efficient channel estimation (2014)

We investigate the main limitations which prevent the continuous-variable quantum key distribution protocols from achieving long distances in the finite-size setting. We propose a double-modulation protocol which allows using each state for both channel estimation and key distribution. As opposed to the standard method, we optimize the parameters of the protocol and consider squeezed as well as coherent states as a signal. By optimally combining the resources the key rate can approach the theoretical limit for long distances, and one can obtain about ten times higher key rate using ten times shorter block size than in the current state-of-the-art implementation.
INTERDISCIPLINARY JOURNAL CLUB: ADVANCING KNOWLEDGE TRANSLATION IN A RURAL STATE (2010)

Professionals who provide health and related supports and services to children with disabilities in educational programs and community settings must practice in an evidence-based manner to ensure children and families receive the highest quality care. Vermont’s Interdisciplinary Journal Club provides a successful approach to supporting professional development of rural professionals through a variety of knowledge translation activities, including: (a) building relationships and communities integral
Self-Imaging in Homogeneous Optical Waveguides (1976)

When an object is placed against one end of an optical waveguide, a real optical image (self-image) of it may be formed at the other end under certain conditions (Fig. 1). In wave-optical terms, these conditions require the phase differences ψ jk =(β j −β k )L between any two excited modes at the end of the guide to be integral multiples of 2π. Here, β j denotes the propagation constant of the j-th mode, and L is the length of the guide. Under these conditions, the interference of the modes in the exit plane of the waveguide is the same as in the entrance plane, and a real image is formed. While it is long known that such an image transmission is possible with guides having a square-law index profile, the imaging property has recently also been demonstrated for planar guides with homogeneous refractive index. 1,2 The planar guide provides only one-dimensional (line ↔ line) imaging in the same sense as a cyclindrical lens. The corresponding two-dimensional (point ↔ point) imaging is possible with dielectric guides of rectangular or square cross-section. In the present paper, these self-imaging processes in guides of homogeneous index are discussed theoretically, and experimental results are presented illustrating this phenomenon.
Generic Ribbons: A Morphological Approach Towards Natural Shape Decomposition (1989)

In this paper, we propose a shape decomposition scheme which decomposes complex shapes into their natural components. Each component is represented by a shape primitives called generic ribbon. A generic ribbon is defined by sweeping a structuring element along a specified trajectory which is decomposed from the morphological skeleton of the shape through the skeleton decomposition. Five decomposition rules are devised to facilitate a natural decomposition. The decomposed generic ribbons form a hierarchical representation in which each component is described by a feature vector placed at a certain level according to its significance in the representation. The hierarchical structure makes the representation reliable and simplifies the matching process during recognition.
Distributed control system for catalysing the formation of artificial rainfall and snow using charged particles (2020)

Abstract In order to solve the limitations and shortcomings of the traditional artificial rainfall technology, researchers all over the world are actively researching new artificial rainfall technologies. The charged particle catalytic artificial rainfall technology is one of the new artificial rainfall technologies. This method uses a charged particle generator set up in the wild to produce charged particles to catalyse rainfall. It is necessary to control all equipment in the experiment site remotely during the experiment. Thus, a control system needs to be implemented. There are many kinds of controlled equipment in this control system, such as high-voltage power supply, meteorological data acquisition devices, and various experimental auxiliary equipment. In this paper, we design and implement a comprehensive control system based on the characteristics of the charged particle catalysed artificial rainfall field experiment and the controlled equipment in the experiment site. The software interface connected to different types of equipment in the system is developed based on the large-scale experimental control system framework CFET, which can easily add equipment and view measurement data. The system is designed as a distributed system connected through a network, which can meet the needs of centralized control of multiple experimental sites.
A 1 volt CMOS 2/4 level FSK digital demodulator for pager applications (2003)

A 2/4-level FSK digital demodulator for integration in a single multi-standard pager chip is presented. The demodulator function is based on counting the zero crossings of the FSK signal. Frequency offset due to crystal imperfections, etc. is corrected. The output BER is 0.7% and 5% for input CNR of 4 dB for 2-level and 4-level FSK respectively with frequency offset of 2 kHz. This design uses 0.8-/spl mu/m CMOS technology and operates with a power supply as low as 1 V.
Mutation rates of structural chromosome rearrangements in man. (1981)

The gametic mutation rates of human structural chromosome rearrangements have been estimated from rearrangements ascertained from systematic surveys of live births and spontaneous abortions. The mutation rates for rearrangements that survive long enough to give rise to clinically recognized pregnancies are 2.20 X 10(-4) for balanced rearrangements, 3.54 X 10(-4) for unbalanced Robertsonian translocations, and 3.42 X 10(-4) for unbalanced non-Robertsonian rearrangements. These estimates give a mutation rate for all detectable structural chromosome rearrangements of approximately 1 X 10(-3). The most common single rearrangement, the Robertsonian translocation involving chromosomes 13 and 14, has a mutation rate of 1.5 X 10(-4).
&#947;-Secretase-Regulated Signaling Pathways, such as Notch Signaling, Mediate the Differentiation of Hematopoietic Stem Cells, Development of the Immune System, and Peripheral Immune Responses (2011)

Notch signaling mediates the fates of numerous cells in both invertebrates and vertebrates. In the immune system, Notch signalling contributes to the generation of hematopoietic stem cells (HSCs), the promotion of HSC self-renewal, T lineage commitment, intrathymic T cell development, and peripheral lymphocyte differentiation/activation. The intracellular domain (ICD) of Notch is released from the cell membrane by γ-secretase and translocates to the nucleus to modulate gene expression. Hence, γ-secretase plays a central role in the regulation of Notch signaling. More than five dozen type 1 transmembrane proteins, including amyloid precursor protein, Notch, and Delta, are substrates for γ-secretase and their ICDs are released from the cell membrane. Therefore, it is highly possible that mechanisms similar to Notch signaling may widely contribute to γ-secretase-regulated signaling. Besides Notch, some transmembrane proteins such as CD44 and CSF-1R, which are important for immune responses, have been reported as substrates for γ-secretase. Since the ICDs of these proteins are also released by γ-secretase from the cell membrane and localize to the nucleus, it is thought that these ICDs modulate gene expression. Thus, γ-secretase-regulated signaling, including Notch signaling, may play a wide range of roles in the immune system.
The activation of ribulose-1,5-bisphosphate carboxylase by carbon dioxide and magnesium ions. Equilibria, kinetics, a suggested mechanism, and physiological implications (1976)

<P>Abstract copyright UK Data Service and data collection copyright owner.</P>The <i>Northern Ireland Family Expenditure Survey</i> (NIFES) was conducted in Northern Ireland from 1967-1998, and was the counterpart to the <i>Family Expenditure Survey</i> (FES), which was conducted annually in Great Britain from 1957-2001 (see under GN 33057). The FES/NIFES provided reliable data on expenditure and income in relation to household characteristics. The results of the survey show how expenditure patterns of different kinds of households vary, and the extent to which individual members of a household contribute to the household income. Although originally commissioned to provide expenditure details for the calculation of weights for the Retail Price Index, the FES/NIFES collected much additional information was also collected on the characteristics of co-operating households and the incomes of their members. It thus became a multi-purpose survey, and provided a unique fund of important economic and social data. <br>\n<br>\nFrom 1968 the Great Britain FES incorporated a sample drawn from the NIFES to become the UK FES. The FES was replaced in 2001 by a new survey series, the <i>Expenditure and Food Survey</i> (EFS) (see under GN 33334), covering the whole of the UK. The EFS is an amalgamation of the previous <i>National Food Survey</i> (NFS) (see under GN 33071) and UK FES.<br>\n<br>\n
Diminishing returns or appropriate treatment strategy? – an analysis of short-term outcomes after pain clinic treatment (1997)

In the United Kingdom patients with chronic pain are frequently managed in anaesthetist-led outpatient pain clinics. In many of these clinics the emphasis is on medical therapies (analgesics and psychotropic drugs, TENS, acupuncture and nerve blocks) with patients trying a series of different therapies until relief is achieved or further attempts at physical treatments are discontinued. The sequential trial of different treatment modalities presents clinicians with a problem. Patients who receive little benefit from (say) the first three treatments tried might be expected to be less likely to gain benefit from the next treatment modality. The presence or absence of such 'diminishing returns' from treatment will influence when therapeutic efforts based on the medical model of pain should be abandoned. This study examined basic outcome data on 1912 patients seen in a single Scottish pain clinic between 1987 and 1994. The data were analysed to assess whether the success of treatment modalities depended on whether they were used as a first-choice treatment or were given after previous therapeutic attempts had failed. Diminution in success rates was generally not large although this varied between therapies. No fall-off in success rates was seen for antidepressants, acupuncture or sympathetic nerve blocks. However, the other nerve blocks all showed falling success rates when they were used as fourth- or fifth-line treatments. That little diminution of success rates was seen warrants further investigation. Pain clinics need good information on the success or otherwise of late treatment so that they can devise rational pain management strategies covering multiple therapies and appropriate criteria for ending medical interventions. These findings suggest that allowing patients access to multiple pain therapies may well be an appropriate management strategy.
ArtQuest and the ASI Art Reference Library (1989)

I am going to talk about the ASI Art Reference Library and about the ArtQuest on line service. The ASI Art Reference Library is a data bank which has been created by Art Sales Index Ltd by gathering and publis hing, over a 20 year period, results of international auction sales. ArtQuest is an on line interrogation service which provides access to this data bank, 24 hours a day, 5 days a week. At such a conference, I am a little shy of offering that little pair of words, 'on-line'. And yet I feel obliged to do so. There might be one or two people in the audience who are not quite clear as to what is meant. My definition, a very simple one:
Impact of Drug Use and Comorbidities on In-Hospital Falls in Patients with Chronic Kidney Disease (2007)

Several comorbidities, especially dementia, significantly increase the risk of experiencing an in-hospital fall in patients with CKD. Drugs that place CKD patients at risk include antidepressants and anticonvulsants.
A Multi-View Enterprise Modeling Scheme (1997)

Efforts to improve enterprise performance depend to a large extent on models of enterprise processes created for analysis and design. This paper describes a modeling scheme which supports the development of a multi-view model of an enterprise and its processes. The paper first presents an overview of the efforts such as business process reengineering, enterprise integration, and enterprise engineering which make use of process models. The paper then presents the modeling scheme which uses the IDEF suite of modeling methods to build integrated business rule, activity, resource, business process, and organizational views of the enterprise. The scheme is built from a central IDEF5 model of the enterprise from which the other views are extracted. INTRODUCTION There is much in the literature regarding efforts and methodologies to improve enterprise performance through the design of processes. Examples are research related to the subjects of business process reengineering, enterprise integ...
Electrophysiological and Cellular Effects of Estrogen on Neuronal Function (1999)

Estrogen exerts a variety of electrophysiological, neurotrophic, and metabolic effects on neurons in the adult central nervous system. Recent epidemiological studies have suggested that estrogen, as hormone replacement therapy in postmenopausal women, may be protective against Alzheimer's disease; the biological basis for a potential neuroprotective effect of estrogen in humans is an area of intense current research. This review summarizes electrophysiological and cellular effects of estrogen on neuronal function, with particular emphasis on hypothalamic and hippocampal neurons. Classic electrophysiological studies are compared with more recent cellular and molecular analyses in an effort to illuminate significant relationships between data gathered over the last 30 years and from varied sources. Hypotheses are made for the mechanisms of estrogen action in the brain as well as the functional consequences of estrogen's effects for both normal brain function and pathological states.
Multicentric Evaluation of a New Assay for Prothrombin Fragment F1+2 Determination (1992)

A multicenter study of a recently developed ELISA for the determination of prothrombin fragment F1+2 was performed in order to evaluate analytical and clinical aspects. Mean intra-assay and inter-assay reproducibility were found to be 11.0 and 12.6%, respectively. The measuring range covered by the calibration curve reaches from 0.04 to 10.0 nM/l F1+2. Testing 133 healthy subjects a reference range of 0.37 to 1.11 nM/l F1+2 (2.5-97.5 percentile) with a median of 0.66 nM/l F1+2 was calculated. Minor difficulties with blood sampling (venous occlusion for 2 min) did not affect F1+2 plasma concentrations. Significantly increased F1+2 levels were measured in patients with leukemia (p < 0.0001), severe liver disease (p < 0.005) and after myocardial infarction (p < 0.01). Elevated F1+2 concentration before the beginning of heparin therapy (1.25 nM/l) decreased to 0.77 nM/l (p < 0.0001) after 1 day of therapy. For patients in the stable phase of oral anticoagulant therapy decreasing F1+2 concentrations were measured with increasing INR. F1+2 levels were already significantly reduced in patients with INR < 2.0 (0.56 nM/l; p = 0.0005). Thus F1+2 determination may be helpful in identifying activation processes as well as in monitoring anticoagulant therapy.
Holographic Optical Elements (1986)

Thesis (Ph. D.)--University of Rochester. College of Engineering and Applied Science. Institute of Optics, 1986.
Where the United States Spends Its Spine Dollars (2012)

Although this study did not explore the relative effectiveness of different ambulatory services, recent increasing costs associated with providing medical care for back and neck conditions (particularly subspecialty care) are contributing to the growing economic burden of managing these conditions.
Hsp90 Is Essential for the Synthesis and Subsequent Membrane Association, But Not the Maintenance, of the Src-Kinase p56<sup><i>lck</i></sup> (2000)

Tyrosine kinases of the Src family are synthesized as cytosolic proteins that subsequently translocate to membranes. Little is known of the mechanisms responsible for targeting these proteins to membranes, although a role for the cytosolic chaperone Hsp90 has been proposed. Here, we have studied the involvement of Hsp90 in the synthesis, membrane binding, and maintenance of the Src-kinase Lck. Using specific inhibitors of Hsp90, geldanamycin and radicicol, we found that functional Hsp90 is essential for the stability of newly synthesized, but not mature, Lck. Similar results were obtained for two other Src-kinases, c-Src and Lyn. In contrast, LckY505F and LckDeltaSH2, constitutively active Lck mutants lacking the C-terminal regulatory tyrosine or the entire Src homology 2 domain, respectively, required Hsp90 activity to stabilize the mature proteins. Lck synthesized in the absence of Hsp90 activity was degraded within 30-45 min. This unstable Lck was myristoylated normally but did not associate with membranes or CD4, interactions that normally start within minutes of the completion of Lck synthesis. A construct composed of the N-terminal unique domain of Lck fused to green fluorescent protein did not require Hsp90 activity during synthesis. In addition, this protein associated with membranes efficiently in the absence of Hsp90 activity. Together these data suggest that interaction with Hsp90 is necessary for the correct synthesis and subsequent membrane binding of Lck. However, Hsp90 does not appear to play a direct role in Lck membrane, or CD4, association.
Operator-Valued Bochner Theorem, Fourier Feature Maps for Operator-Valued Kernels, and Vector-Valued Learning (2016)

This paper presents a framework for computing random operator-valued feature maps for operator-valued positive definite kernels. This is a generalization of the random Fourier features for scalar-valued kernels to the operator-valued case. Our general setting is that of operator-valued kernels corresponding to RKHS of functions with values in a Hilbert space. We show that in general, for a given kernel, there are potentially infinitely many random feature maps, which can be bounded or unbounded. Most importantly, given a kernel, we present a general, closed form formula for computing a corresponding probability measure, which is required for the construction of the Fourier features, and which, unlike the scalar case, is not uniquely and automatically determined by the kernel. We also show that, under appropriate conditions, random bounded feature maps can always be computed. Furthermore, we show the uniform convergence, under the Hilbert-Schmidt norm, of the resulting approximate kernel to the exact kernel on any compact subset of Euclidean space. Our convergence requires differentiable kernels, an improvement over the twice-differentiability requirement in previous work in the scalar setting. We then show how operator-valued feature maps and their approximations can be employed in a general vector-valued learning framework. The mathematical formulation is illustrated by numerical examples on matrix-valued kernels.
The Decision-Making Analysis of Adoption Subjects of Financial Innovation (2009)

This paper analyses that the micro decision-making behaviors of the adoption subjects of financial innovation activities, it demonstrates that the decision-making behaviors are the investment problems under conditions of uncertainty to a large extent, and the subjects has the right to delay investment. The paper adopted a monopolistic real option model to describe the basic decision-making behaviors of innovation individuals facing innovation opportunities. Compared with the traditional net present value (NPV) rules, the authors conclude that the value of the investment opportunities that be calculated by real option method give full consideration to the volatility in the future and the corresponding changes of decision-making, and it provides a more objective and reasonable theoretical basis for investment decision-making of financial innovation activities.