gebhart/patrepeval huggingface dataset:
Interleukin-37 Relieves Allergic Inflammation in a House Dust Mite Allergic Rhinitis Murine Model. (2017)

The purpose of this study was to investigate the effects of interleukin-37 (IL-37) on a Dermatophagoides farinae (Der f)-induced murine model of allergic rhinitis (AR). BALB/c mice, except the control groups, were sensitized intraperitoneally and challenged intranasally with Der f (Der f group). The IL-37 and IL-37+anti-CD25 groups were administered IL-37 intranasally. The IL-37+anti-CD25 groups were administered anti-CD25 monoclonal antibody intraperitoneally before challenge. Allergic symptoms and the average eosinophil number were counted. The levels of cytokines and transcription factors in the nasal mucosa were measured by Real-Time polymerase chain reaction (PCR) and western blotting. The levels of Der f-specific immunoglobulin E (IgE) were measured. The CD4+CD25+Foxp3+T cells among splenic mononuclear cells were analyzed by flow cytometry. The allergic symptom scores and Der f-specific IgE levels were lower in the IL-37 group compared to the Der f group. Additionally, the levels of the transcription factor GATA-3 and ROR-γt and those of the cytokines IL-4, IL-5, IL-13, and IL-17, representing both T helper (Th)2 and Th17 responses, were lower in the IL-37 group in comparison with the Der f group. However, the Th1 responsewas not suppressed after administration of IL-37. IL-37 increased the IL-10 level; however, Real-Time PCR, western blotting, and flow cytometry results showed the limited action of IL-37 on CD4+CD25+Foxp3+T cells. This study demonstrates that intranasal IL-37 can suppress Th2 and Th17 responses in an AR murine model. Furthermore, these data suggest that IL-10 is increased, but CD4+CD25+Foxp3+T cells are not correlated with the IL-37-induced mechanism.
Quantum Theory of DNA (2006)

Inspired by Ikemura conjecture about electron transfer in DNA playing an important role in information exchanges, the field theoretical approach is applied to π-electrons and phonons inside DNA. Under some approximations, three-dimensional string action is derived. The DNA string model is applied to formulate the three phenomena – luminescence quenching, eletric current through DNA and absorption of light.
A user study of visual versus sonically-enhanced interfaces for use while walking (2010)

This paper presents a user study on interaction with a mobile device. We investigate the use of non-speech sound in mobile interfaces and design a sonically-enhanced interface. The sonically-enhanced interface is compared to a visual interface when users are walking. The results show that the sonically-enhanced interface can improve the mobile interaction as compared to the visual interface.
GREYC keystroke: A benchmark for keystroke dynamics biometric systems (2009)

Even if the market penetration rate of biometric technologies is still far below its potential, many biometric systems are used in our daily real-life. One of the main reasons to its low proliferation is the lack of a generic and complete approach that quantifies the performance of biometric systems taking into account individuals' perception among the process. Among all the existing biometric modalities, authentication systems based on keystroke dynamics are particularly interesting. Many researchers proposed in the last decades some algorithms to increase the efficiency of this approach. Nevertheless, none significant benchmark is available and commonly used in the state of the art to compare them by using a similar and rigorous protocol. We propose in this paper: a benchmark testing suite composed of a database and a software that are available for the scientific community for the evaluation of keystroke dynamics based systems. Performance evaluation of various keystroke dynamics methods tested on the database is available in (R. Giot et al., 2009).
Impact of Customer Retention Practices on Firm Performance (2013)

Customer retention has become the buzzword among both practitioners and academics due to its significant impact towards the improvement in firm performance. Though firm performance is normally evaluated using financial measures, this paper has utilized non-financial measure i.e. customer satisfaction. This is due to the appropriateness of its application to measure performance of service-oriented (retail) firms. This study was conducted using mall-intercept surveys at AEON Perak, Malaysia whereby, it collected 200 completed questionnaires. Hierarchical regression analysis was employed to examine the impact of customer retention towards firm performance alongside with the demographic profiles as the moderator. Four dimensions of customer retention namely word-of-mouth, price insensitivity, repeat purchase and non-complaining behavior as well as demographic profiles are found to significantly influence firm performance (customer satisfaction). Hence, it is recommended that practitioners should be more considerate towards enriching the said dimensions of customer retention in order to leverage its promising potential.
Defining the Curvature of a Statistical Problem (with Applications to Second Order Efficiency) (1975)

Statisticians know that one-parameter exponential families have very nice properties for estimation, testing, and other inference problems. Fundamentally this is because they can be considered to be "straight lines" through the space of all possible probability distributions on the sample space. We consider arbitrary one-parameter families $\mathscr{F}$ and try to quantify how nearly "exponential" they are. A quantity called "the statistical curvature of $\mathscr{F}$" is introduced. Statistical curvature is identically zero for exponential families, positive for nonexponential families. Our purpose is to show that families with small curvature enjoy the good properties of exponential families. Large curvature indicates a breakdown of these properties. Statistical curvature turns out to be closely related to Fisher and Rao's theory of second order efficiency.
Effects of aging on human skeletal muscle after immobilization and retraining (2009)

Inactivity is a recognized compounding factor in sarcopenia and muscle weakness in old age. However, while the negative effects of unloading on skeletal muscle in young individuals are well elucidated, only little is known about the consequence of immobilization and the regenerative capacity in elderly individuals. Thus the aim of this study was to examine the effect of aging on changes in muscle contractile properties, specific force, and muscle mass characteristics in 9 old (61-74 yr) and 11 young men (21-27 yr) after 2 wk of immobilization and 4 wk of retraining. Both young and old experienced decreases in maximal muscle strength, resting twitch peak torque and twitch rate of force development, quadriceps muscle volume, pennation angle, and specific force after 2 wk of immobilization (P < 0.05). The decline in quadriceps volume and pennation angle was smaller in old compared with young (P < 0.05). In contrast, only old men experienced a decrease in quadriceps activation. After retraining, both young and old regained their initial muscle strength, but old had smaller gains in quadriceps volume compared with young, and pennation angle increased in young only (P < 0.05). The present study is the first to demonstrate that aging alters the neuromuscular response to short-term disuse and recovery in humans. Notably, immobilization had a greater impact on neuronal motor function in old individuals, while young individuals were more affected at the muscle level. In addition, old individuals showed an attenuated response to retraining after immobilization compared with young individuals.
A tracking and predicting scheme for ping pong robot (2011)

We describe a new tracking and predicting scheme applied to a lab-made ping pong robot. The robot has a monocular vision system comprised of a camera and a light. We propose an optimized strategy to calibrate the light center using the least square method. An ellipse fitting method is used to precisely locate the center of ball and shadow on the captured image. After the triangulation of the ball position in the world coordinates, a tracking algorithm based on a Kalman filter outputs an accurate estimation of the flight states including the ball position and velocity. Furthermore, a neural network model is constructed and trained to predict the following flight path. Experimental results show that this scheme can achieve a good predicting precision and success rate of striking an incoming ball. The robot can achieve a success rate of about 80% to return a flight ball of 5 m/s to the opposite court.
Advances and directions of ion nitriding/carburizing (1989)

Ion nitriding and carburizing are plasma activated thermodynamic processes for the production of case hardened surface layers not only for ferrous materials, but also for an increasing number of nonferrous metals. When the treatment variables are properly controlled, the use of nitrogenous or carbonaceous glow discharge medium offers great flexibility in tailoring surface/near-surface properties independently of the bulk properties. The ion nitriding process has reached a high level of maturity and has gained wide industrial acceptance, while the more recently introduced ion carburizing process is rapidly gaining industrial acceptance. The current status of plasma mass transfer mechanisms into the surface regarding the formation of compound and diffusion layers in ion nitriding and carbon build-up ion carburizing is reviewed. In addition, the recent developments in design and construction of advanced equipment for obtaining optimized and controlled case/core properties is summarized. Also, new developments and trends such as duplex plasma treatments and alternatives to dc diode nitriding are highlighted.
Synthesis and pp60<sup>c‐Src </sup>Tyrosine Kinase Inhibitory Activities of Novel Indole‐3‐Imine and Amine Derivatives Substituted at N1 and C5 (2009)

A series of novel 1,3,5-trisubstituted indole derivatives, namely, N-benzyl 5-phenyl indole-3-imine, N-benzyl-5-(p-fluorophenyl)indole-3-imine and their corresponding amine congeners, were designed and synthesized as pp60(c-Src) tyrosine kinase inhibitors, and their inhibitory activities toward pp60(c-Src) tyrosine kinase were evaluated by in-vitro kinase assay. Pre-screening at two doses of compounds against kinase target revealed that, except for the N-benzyl-5-phenyl indole imine derivatives 7a-7d, all indole derivatives show the target inhibition at varying levels. Consequently, the compounds, 8c, 8f, 8g, and 8h, were selected for prescreening tests. The dose-response curves for up to six concentrations (250 to 7.8 muM) of the active compounds were obtained by tyrosine kinase assay and the four-parameter logistic analysis of these data resulted in the IC(50)s of 4.69, 74.79, 75.06, and 84.23 muM for compounds 8c, 8f, 8g, and 8h, respectively. Therefore, compound 8c, 1-(1-benzyl-5-phenyl-1H-indole-3-yl)-N-(4-fluorobenzyl)methanamine.HCl, was the promising inhibitor for pp60(c-Src), followed by compounds 8g and 8h. Under the same conditions, compound 8f did not provide any reasonable inhibition pattern to be considered as active compound. Therefore, among all four active compounds, compound 8f was not found suitable for further analysis.
From comb polymers to polysoaps: a Monte Carlo attempt (1998)

The pivot algorithm is used on a cubic lattice to study comb polymers large enough to have side-chains obeying scaling behaviour. The connectivity of the chain induces the formation of side-chain clusters whose size distribution is investigated as a function of side-chain length n and spacer length m. When an attractive interaction is set between the side-chains, the comb polymer displays the behaviour of an associating polymer below the critical aggregation concentration, as observed experimentally.
Can chronic post-sternotomy pain after cardiac valve replacement be reduced using thoracic epidural analgesia? (2002)

s: European Association of Cardiothoracic Anaesthesiologists; 17th Annual Meeting; Dublin, Ireland; June 12-15, 2002: The Postoperative Period
Tri-iodothyronine increases insulin-like growth factor binding protein-4 expression in rat hepatocytes (1997)

Previous in vivo studies demonstrated significant variations in insulin-like growth factor binding protein-1 (IGFBP-1), IGFBP-2 and IGFBP-4 hepatic mRNAs and/or serum levels depending on the rat thyroid status. In this study we employed cultured hepatocytes from adult rats to demonstrate a possible direct regulation of these genes by tri-iodothyronine (T3). Northern blot analysis revealed that IGFBP-1 and -4 messages were clearly expressed, whereas IGFBP-2 signal was barely detectable. No significant effects on IGFBP-1 mRNA level or on peptide secretion were detected in T3-cultured hepatocytes. In contrast, significant increases in IGFBP-4 mRNA steady-state levels as well as in IGFBP-4 secretion were observed in hepatocytes cultured for 12-24 h in the presence of T3. The T3 effect on IGFBP-4 transcript levels appears to consist of enhanced gene transcription and is independent of ongoing protein synthesis. The T3-increased IGFBP-4 expression in cultured hepatocytes is consistent with our in vivo experiments demonstrating an increase in hepatic IGFBP-4 mRNA and serum IGFBP-4 levels in T3-treated rats. Furthermore, significant decreases in hepatic IGFBP-4 message and serum IGFBP-4 levels were observed in hypothyroid rats compared with euthyroid controls. Our data establish an important direct role for thyroid hormone in regulating IGFBP-4 expression and consequently IGF activity.
Desmoid tumors: To treat or not to treat, That is the question (2020)

Desmoid tumors (DTs) are a rare disease of intermediate malignancy characterized histologically by a locally aggressive, monoclonal, fibroblastic proliferation and clinically by a variable and often unpredictable course. For decades, surgical resection has been the standard initial treatment approach; however, more recently, a paradigm shift toward a more conservative treatment strategy has been introduced. More than 5 years ago, The Desmoid Tumor Working Group started a consensus initiative in Europe with the aim of harmonizing the strategy among clinicians and setting up treatment recommendations for patients with DTs. This review summarizes the latest joint, global, evidence-based guideline approach to DT management. Moreover, a number of gray areas in the treatment recommendations are discussed, and possible future perspectives on the treatment armamentarium for patients with DTs are presented.
Comparing PSO structures to learn the game of checkers from zero knowledge (2003)

This paper investigates the effectiveness of various particle swarm optimiser structures to learn how to play the game of checkers. Co-evolutionary techniques are used to train the game playing agents. Performance is compared against a player making moves at random. Initial experimental results indicate definite advantages in using certain information sharing structures and swarm size configurations to successfully learn the game of checkers.
Prediction of protein stability changes for single‐site mutations using support vector machines (2005)

Accurate prediction of protein stability changes resulting from single amino acid mutations is important for understanding protein structures and designing new proteins. We use support vector machines to predict protein stability changes for single amino acid mutations leveraging both sequence and structural information. We evaluate our approach using cross-validation methods on a large dataset of single amino acid mutations. When only the sign of the stability changes is considered, the predictive method achieves 84% accuracy-a significant improvement over previously published results. Moreover, the experimental results show that the prediction accuracy obtained using sequence alone is close to the accuracy obtained using tertiary structure information. Because our method can accurately predict protein stability changes using primary sequence information only, it is applicable to many situations where the tertiary structure is unknown, overcoming a major limitation of previous methods which require tertiary information. The web server for predictions of protein stability changes upon mutations (MUpro), software, and datasets are available at http://www.igb.uci.edu/servers/servers.html.
On the Use of Indicator Variables for Studying the Time-Dependence of Parameters in a Response-Time Model (1975)

The study of the dependence of response-time data on a multivariate regressor variable in the presence of arbitrary censoring has been approached in a number of ways. The exponential regression model proposed byr Feigl and Zelen [1965] and extended by Zippin and Armitage [1966] and by Mantel and Myers [1971] to the case of arbitrarily right censored data relates the reciprocal of the exponential parameter, i.e. the expected survival time, to a linear function of the regressor variables. Later, Glasser [1967] proposed an exponential model in which the logarithm of the exponential parameter was assumed to be a linear function of the regressor variables. In both formulations the rather stringent assumption of a constant hazard may be dropped by the assumption of a more general response-time distribution such as the Weibull, gamma or Gompertz, each of which contains the exponential as a special case. The nonparametric model proposed by Cox [1972] admits an arbitrary response-time distribution and, for discrete data, becomes a logistic regression model. An alternative version of Cox's discrete model has beenl proposed by Kalbfleisch and Prentice [1973]. These approaches have the advantage of not specifying the hazard function in advance and, as such, are more robust than the above parametric methods. Their major drawback, however, is the computational difficulties in the presence of tied response times. In many practical situations the data are recorded in such a way as to make this a very real problem and serious enough to implv that an alternative procedure may be desirable. This logistic regression model was also used by Myers et al. [1973] in conjunction with the assumption of a constant hazard. The model they considered incorporated concomitant information by assuming that the probability of responding within a unit time period followed a logistic regression function, while the actual time to response followed a particular distributional form. They chose a form which assumed a time-independent risk of responding-the exponential for a continuous time process or geometric for discrete time. This approach was extended by Hankey and Mantel [1974] by the addition of a time function to the logistic regression function. This tinme function was approximated by a low order polynomial. Inherent in these exponential and logistic regression models is the assumption that the effects of the covariates are independent of time. The exponential model of Feigl and Zelen relates the expected survival time to the concomitant information and, since the exponential distribution is without memory, the expected remaining survival timne given survival up to some time point T has the same relationship to the concomitant information no matter what the value of T. The logistic regression methods that have been proposed allow the underlying hazard to be a function of time but the relative effects of the covariates
A Literature Review of the Human Body as a Communication Medium using RedTacton (2016)

At present many technologies for networking are known and are in use. These technologies connect people, objects and other networks together so as to dispense data and thus make information ready for access. In the world of computers, networking is the practice of linking two or more computing devices together for the purpose of dispensing data. In this paper, we introduce novel networking technology called RedTacton was announced by NTT labs from Japan in 2005, which makes use of human body surface as communication medium when exchanging data among people, objects and networks. The RedTacton takes a different technical viewpoint. Instead of relying on electromagnetic waves or light waves to carry data, RedTacton uses feeble electric fields on the surface of the body as a transmission medium. Electricfield communication is dissimilar from orthodox wireless or infrared communication which simply does not rely on electromagnetic or light wave to transmit data because it uses the electric field procreate on the surface of the human body. This is mainly developed to conquer an interposing of unwanted signal in intensive places has become a major issue and the better solution to this can be, a human body functioning as non-stop transmitter and receiver. The RedTacton communication is possible using any body surfaces, such as the hands, fingers, arms, feet, face, legs or toes. Red Tacton can be used in any media including water, glass, wood, shoes and clothing as well etc. The electric field/Photonics method employed by Red Tacton is preferable to conventional methods in terms of communication distance, speed, and interactivity. In this paper, I will discuss about RedTacton, and it's working states, body coupled communications, transceiver and applications of RedTacton in various fields.
Research Profiles: LD-MS detects malaria parasite (2002)

ADVERTISEMENT RETURN TO ISSUEPREVNewsNEXTResearch Profiles: LD-MS detects malaria parasiteRachel PetkewichCite this: Anal. Chem. 2002, 74, 15, 409 APublication Date (Web):August 1, 2002Publication History Published online1 August 2002Published inissue 1 August 2002https://pubs.acs.org/doi/10.1021/ac0220880https://doi.org/10.1021/ac0220880newsACS Publications. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views171Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (58 KB) Get e-Alertsclose SUBJECTS:Parasites Get e-Alerts