gebhart/patrepeval huggingface dataset:
Frameworks for Computational Design of Textile Micro-Architectures and Material Behavior in Forming Complex Force-Active Structures (2013)

Material behavior can be defined as the confluence of associative rules, contextual pressures and constraints of materialization. In more general terms, it can be parameterized as topologies, forces and materiality. Forming behavior means resolving the intricate matrix of deterministic and indeterministic factors that comprise and interrelate each subset of these material- nherent conditions. This requires a concise design framework which accumulates the confluent behavior through successive and cyclical exchange of multiple design modes, rather than through a single design environment or set of prescribed procedures. This paper unfolds a sequencing of individual methods as part of a larger design framework, described through the development of a series of complex hybrid- structure material morphologies. The ÂhybridÂ nature reflects the integration of multiple force-active structural concepts within a single continuous material system, devising both self-organized yet highly articulated spatial conditions. This leads primarily to the development of what is termed a Âtextile hybridÂ system: an equilibrium state of tensile surfaces and bending-active meshes. The research described in this paper looks to expose the structure of the textile as an indeterministic design parameter, where its architecture can be manipulated as means for exploring and differentiating behavior. This is done through experimentation with weft-knitting technologies, in which the variability of individual knit logics is instrumentalized for simultaneously articulating and structuring form. Such relationships are shown through an installation constructed at the ggggallery in Copenhagen, Denmark.
Reduction of 4-oxo α-amino acids as a route to 4-hydroxylated α-amino acids. Concise approaches to the synthesis of clavalanine, erythro-4-hydroxyornithine and (+)-bulgecinine (1994)

The stereochemical course of reduction of derivatives of 4-oxo α-amino acids 3 to give cis- and trans-γ-substituted α-aminobutano-4-lactones 9 and 10 using a range of hydride reducing agents is reported. Although reduction with sodium boranuide (sodium borohydride) in protic solvents proceeds with low stereoselectivity, use of triethylsilane–boron trifluoride–diethyl ether gives good selectivity in favour of the cis-isomer, provided that the 4-substituent is phenyl. Moderate to excellent stereoselectivity in favour of the trans-isomer may be obtained by using L-Selectride® in tetrahydrofuran. The presence of an additional stereogenic centre at C-5 completely overwhelms the effect of the α-centre. Applications of this method in approaches to the synthesis of clavalanine, erythro-4-hydroxyornithine and (+)-bulgecinine are described.
ChemInform Abstract: STRAINED HETEROCYCLIC COMPOUNDS. 10. INTRODUCTION OF AN AMIDE SIDE CHAIN IN PLACE OF HALOGEN IN 7‐HALO‐8‐OXO‐1‐AZABICYCLO(4.2.0)OCTANE (1976)

Abstract Die Reaktion des trans‐Bromlactams (Ia) mit dem Phthalimid (II) gibt überwiegend das cis‐Phthalimido‐ Derivat (IIIa) verunreinigt mit seinem Isomeren (IIIb) (4% Ausbeute), Phthalimid (16%) und nichtumgesetztem (Ia) (24%); unter analogen Bedingungen bildet sich aus (Ib) ausschließlich das trans‐Lactam (IIIb).
Use of a Fiber Optic-Based, Laser-Induced Breakdown Spectroscopy (LIBS) Probe for In Situ Determination of Metals in Soils (1998)

A Cone Penetrometer-deployed fiber optic probe for the in-situ assessment of metal contamination of soil is described. In this talk both system design features and field-testing results will be discussed.
Quantifying standing posture during multi-joint movements (2012)

Click to increase image sizeClick to decrease image sizeKeywords: center of pressuremulti scale entropymulti-joint movementupper-limb
Test setup for tire/road noise caused by road impact excitations (2006)

status: Published
Stereoselective synthesis of racemic grandisol (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective synthesis of racemic grandisolR. C. Gueldner, A. C. Thompson, and P. A. HedinCite this: J. Org. Chem. 1972, 37, 11, 1854–1856Publication Date (Print):June 1, 1972Publication History Published online1 May 2002Published inissue 1 June 1972https://pubs.acs.org/doi/10.1021/jo00976a053https://doi.org/10.1021/jo00976a053research-articleACS PublicationsRequest reuse permissionsArticle Views291Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mechanism of the Antigen-Independent Cytokinergic SPE-7 IgE Activation of Human Mast Cells in Vitro (2015)

Release of pro-inflammatory mediators by mast cells is a key feature of allergic disease. The 'dogma' is that IgE molecules merely sensitise mast cells by binding FcεRI prior to cross-linking by multivalent allergen, receptor aggregation and mast cell activation. However, certain monoclonal IgE antibodies have been shown to elicit mast cell activation in an antigen-independent cytokinergic manner, and DNP-specific murine SPE-7 IgE is the most highly cytokinergic antibody known. We show that both monovalent hapten and recombinant SPE-7 IgE Fab inhibit its cytokinergic activity as measured by mast cell degranulation and TNF-α release. Using SPE-7 IgE, a non-cytokinergic human IgE and a poorly cytokinergic murine IgE, we reveal that interaction of the Fab region of 'free' SPE-7 IgE with the Fab of FcεRI-bound SPE-7 IgE is the basis of its cytokinergic activity. We rule out involvement of IgE Fc, Cε1 and Cλ/κ domains, and propose that 'free' SPE-7 IgE binds to FcεRI-bound SPE-7 IgE by an Fv-Fv interaction. Initial formation of a tri-molecular complex (one 'free' IgE molecule cross-linking two receptor-bound IgE molecules) leads to capture of further 'free' and receptor-bound IgEs to form larger clusters that trigger mast cell activation.
Head for gas control and instrumentation plugging of a test device for the Jules Horowitz Reactor (2013)

Experimental irradiations carried out in Material Testing Reactors are most of the time highly instrumented. The numbers of detectors as well as the sophistication of test devices have been increasing for years, in order to collect the maximum of information from an irradiation. Various needs have to be satisfied especially when it deals with the development of the new generation of research reactor such as the Jules Horowitz Reactor (JHR). A test device is composed of two main parts: the containment rig and the sample-holder. The containment rig is the outer shell of the test device that houses fluids. The sample-holder is plugged into the containment rig through the circular opening situated in the upper part. It holds the material samples to be irradiated and the specific experimental instrumentation such as thermocouples, radiations sensors, pressure sensors, strain gauges, displacement transducers, etc. In the case of the JHR, in-core test devices are located inside the reactor core which is under a few meters of water. To transfer signals from sensors to the out-of pile I&C system and to power electrical heaters and actuators, interconnection cables carrying electrical wires are routed to the so-called head of the test device. It is an underwater sealed junction box situated at the top of the test device above the reactor vessel cover. The specificities of the JHR lead to develop an advanced integrated head embedding many components such as hermetic electrical interfaces and pressure sensors for monitoring the gas of the test device. Keeping the size smaller enough, push-pull multipole connectors are implemented to allow fast disconnection during monthly handling phase between two reactor cycles. To check the easiness of changing sensors, plugging/unplugging actions, tightness of circuits, a specific hard mockup was manufactured and tested.
Manipulating the Properties of Polyelectrolyte Microcapsules by Glutaraldehyde Cross-Linking (2005)

The stability of hollow microcapsules against environmental alterations such as pH, osmotic pressure, and temperature is a critical issue for practical applications. It is demonstrated here that multilayer capsules assembled from poly(allylamine hydrochloride) (PAH) and sodium poly(styrene sulfonate) (PSS) can be considerably stabilized by cross-linking of only the PAH component with glutaraldehyde (GA). Formation of a Schiff base between the aldehyde and the amine groups was evidenced by UV−vis spectroscopy. After cross-linking by 2% GA for 2 h, an apparently thicker capsule wall was obtained with higher folds, and no alteration of the macroscopic topology of the capsules was observed after incubation in 0.1 M NaOH for 24 h. The cross-linking significantly improved the mechanical strength of the capsules to resist osmotic pressure induced invagination. Consequently, both the critical pressure and the elasticity modulus (680 MPa) of the capsule wall were doubled compared with that of the control. The cross-linking also greatly lowered the permeability of the capsule wall, as evidenced by confocal laser scanning microscopy and fluorescence recovery after photobleaching. Quantitative analysis revealed that the permeation coefficient for dextran (Mw ∼ 250 kD) was reduced by a factor of 3 after cross-linking.
The Therapist, an Expert Witness in a Custody Case: (1983)

A case study of the role of an occupational therapist as an expert witness in a custody hearing of an abused child is presented. The court process is described and suggestions are provided for appropriate preparation for therapists who may be asked for court testimony.
Signal-Injection-Assisted Full-Order Observer With Parameter Adaptation for Synchronous Reluctance Motor Drives (2014)

A back-electromotive-force-based position observer for motion-sensorless synchronous reluctance motor (SyRM) drives is augmented with parameter adaptation laws for improved operation at all speeds, including standstill. The augmented observer is theoretically analyzed under various operating conditions. The analysis indicates that the stator-resistance adaptation should be enabled only at low speeds, the d-axis inductance adaptation should be enabled only at medium and high speeds near no load, and the q-axis inductance adaptation should be enabled only at high speeds under high load. The augmented observer is experimentally evaluated using a 6.7-kW SyRM drive.
ChemInform Abstract: Artificial Photosynthesis over Graphene—Semiconductor Composites. Are We Getting Better? (2015)

Abstract Review: 137 refs.
ChemInform Abstract: Reaction of Antitumor Hydroxymethylacylfulvene (HMAF) with Thiols. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ultrathin films on copper(i) oxide water splitting photocathodes: a study on performance and stability (2012)

The utilisation of Cu2O photocathodes for photoelectrochemical water splitting requires their stabilisation due to photocorrosion in aqueous electrolytes. Ultrathin films of wide band gap semiconducting oxides deposited by atomic layer deposition (ALD) on top of cuprous oxide can perform the dual function of both facilitating charge extraction (through the creation of a p–n junction) and protecting the absorber material from the aqueous electrolyte, thereby suppressing corrosion in favor of hydrogen generation. The factors that determine the photocurrent performance as well as the stability of these photoelectrodes are examined. Specifically, the influence of ALD deposition temperature, electrolyte pH, electrolyte composition as well as post-deposition annealing treatments was studied. The successful development of protective overlayers must fulfil the dual requirements of favourable band alignments as well as chemical stability. At long time scales, the deactivation of the photocathodes proceeds through etching of the amorphous overlayer, accompanied by the loss of the platinum catalyst particles. Through the deposition of a semi-crystalline TiO2 overlayer, 62% stability over 10 hours of testing has been demonstrated without re-platinization.
Study of a wire-driven leg rehabilitation system (2003)

We propose here a new type of leg rehabilitation system. The aim of the system is to realize the multiple-degree-of-freedom (DOF) training of a leg by manipulating the patient's leg with wires. First, a single-DOF experimental system was built and tested, and the experimental results showed the feasibility of a wire-driven leg rehabilitation system. Next, a 2-DOF experimental system was designed, with a target motion of flexion/extension of both the hip and knee joints. Experiments of single-DOF motion on a test dummy and a male subject showed that the system generated enough accurate motion to support a range of motion exercises. In addition, the results demonstrate that the wire-driven mechanism is user friendly.
Engineering Proteins for Custom Inhibition of Ca<sub>V</sub>Channels (2009)

The influx of Ca(2+) ions through voltage-dependent calcium (Ca(V)) channels links electrical signals to physiological responses in all excitable cells. Not surprisingly, blocking Ca(V) channel activity is a powerful method to regulate the function of excitable cells, and this is exploited for both physiological and therapeutic benefit. Nevertheless, the full potential for Ca(V) channel inhibition is not being realized by currently available small-molecule blockers or second-messenger modulators due to limitations in targeting them either to defined groups of cells in an organism or to distinct subcellular regions within a single cell. Here, we review early efforts to engineer protein molecule blockers of Ca(V) channels to fill this crucial niche. This technology would greatly expand the toolbox available to physiologists studying the biology of excitable cells at the cellular and systems level.
Arbitrary rate maximum-distance separable wavelet codes (2002)

This paper expands on the idea of wavelet coding. It undertakes construction of arbitrary rate error correcting codes using finite-field wavelets and filter banks. We show that a rate K / L code can be constructed by a combination of a K-band trivial analysis bank and an L-band synthesis bank. Several issues regarding these wavelet codes are investigated. Among other results, we develop a methodology to construct maximum-distance separable (MDS) codes using finite-field wavelets. In this method, a rate K / L code is constructed by a direct sum of the K rate 1/L subcodes which have been designed using the Bose-Chaudhuri-Hocquenghem (BCH) bound such that their direct sum generates an MDS code.
Accelerator based photon beams, generation and applications at Kyoto University (2011)

Studies on generation and application of accelerator based photon beams whose wavelength from MIR to THz has been conducted in Kyoto University. MIR-FEL facility, KU-FEL, consisted of a 40 MeV electron linac as an FEL deriver and 1.6 m undulator generates 12-14 μm photon beams with peak power of 2 MW. The material analysis laboratory has been constructed for MIR-FEL users especially for developments of energy material. Design study of a table-top THz FEL amplifier has been performed to extend the available wavelength region.
Closing the Loop in IoT-enabled Manufacturing Systems: Challenges and Opportunities (2018)

Revolutionary computing technologies are driving significant advances in the manufacturing domain. High-fidelity simulations and virtual design environments allow unprecedented opportunities to test and validate systems before they are built, reducing overall design time, and cost. These simulations can be run in real-time, in parallel to the physical system, to enable better visibility into plant floor operations. Torrents of data streaming from both simulations and the factory floor can be collected over high-speed networks, and stored in the cloud, enabling improved analytics, predictions, and performance. This paper will describe how the integration of simulation and plant-floor data can enable new control approaches that are able to optimize overall performance of manufacturing system operations. New opportunities for control engineers within the manufacturing sector will be highlighted.
Fulminant and fatal gas gangrene of the stomach in a healthy live liver donor (2004)

A 57-year-old male with a history of hypercholesterolemia and anxiety but otherwise in good health volunteered to donate the right lobe of his liver to his brother. The operation was performed uneventfully, without transfusion. Postoperatively he did well, until he developed tachycardia, profound hypotension, and coffee ground emesis on postoperative day 3. Despite resuscitative measures, he arrested and expired. Autopsy demonstrated gas gangrene of the stomach as the underlying cause of the hemorrhage and numerous colonies of Gram-positive bacilli were identified. Subsequent polymerase chain reaction (PCR) analysis identified these bacteria to be Clostridium perfringens (C. perfringens) type D. This patient's death was devastating, both to his family and his medical team. The impact of his death has transcended that of an individual occurrence. In conclusion, herein we present the facts and discuss this extraordinary example of florid clostridial infection and toxin-mediated shock. It was completely unexpected and probably unpreventable, and its cause was almost inconceivable.
Analysis of immunoglobulin variable region genes of a human IgM anti‐myeloperoxidase antibody derived from a patient with vasculitis (1996)

Circulating antibodies to myeloperoxidase (MPO) are associated primarily with pauci-immune glomerulonephritis and systemic vasculitis. Anti-MPO antibodies belong to a group of autoantibodies, anti-neutrophil cytoplasmic antibodies, that may play a pathogenic role in vasculitis. We have generated a human monoclonal anti-MPO antibody (E3-MPO) using peripheral blood lymphocytes from a patient with microscopic polyarteritis. Variable region gene analysis of E3-MPO showed that the VH region had 90% homology with the germ line gene VH4-21. E3-MPO was also shown to carry the 9G4 idiotope, which so far has been associated only with human antibodies that utilize the VH4-21 gene. The 9G4 idiotope was also expressed on anti-MPO antibodies in sera from the donor patient and from 4/7 additional patients with active, untreated vasculitis. The nucleotide sequences of both the variable heavy and light chains of E3-MPO showed evidence of an antigen-driven response.
MKK6/3 and p38 MAPK Pathway Activation Is Not Necessary for Insulin-induced Glucose Uptake but Regulates Glucose Transporter Expression (2001)

p38 mitogen-activated protein kinase (MAPK), which is situated downstream of MAPK kinase (MKK) 6 and MKK3, is activated by mitogenic or stress-inducing stimuli, as well as by insulin. To clarify the role of the MKK6/3-p38 MAPK pathway in the regulation of glucose transport, dominant negative p38 MAPK and MKK6 mutants and constitutively active MKK6 and MKK3 mutants were overexpressed in 3T3-L1 adipocytes and L6 myotubes using an adenovirus-mediated transfection procedure. Constitutively active MKK6/3 mutants up-regulated GLUT1 expression and down-regulated GLUT4 expression, thereby significantly increasing basal glucose transport but diminishing transport induced by insulin. Similar effects were elicited by chronic (24 h) exposure to tumor necrosis factor alpha, interleukin-1beta, or 200 mm sorbitol, all activate the MKK6/3-p38 MAPK pathway. SB203580, a specific p38 MAPK inhibitor, attenuated these effects, further confirming that both MMK6 and MMK3 act via p38 MAPK, whereas they had no effect on the increase in glucose transport induced by a constitutively active MAPK kinase 1 (MEK1) mutant or by myristoylated Akt. In addition, suppression of p38 MAPK activation by overexpression of a dominant negative p38 MAPK or MKK6 mutant did not diminish insulin-induced glucose uptake by 3T3-L1 adipocytes. It is thus apparent that activation of p38 MAPK is not essential for insulin-induced increases in glucose uptake. Rather, p38 MAPK activation leads to a marked down-regulation of insulin-induced glucose uptake via GLUT4, which may underlie cellular stress-induced insulin resistance caused by tumor necrosis factor alpha and other factors.
Bacteriocins (meningocins) in Norwegian isolates of <i>Neisseria meningitidis:</i> possible role in the course of a meningococcal epidemic (2008)

In the Neisseria meningitidis strain MC58 (serogroup B; ET-5 complex) genome three putative islands of horizontally transferred DNA (IHTs) have been identified. IHT-A2 codes for eight hypothetical proteins and two disrupted open reading frames with similarity to a secretion protein (NMB0097) and an ABC transporter (NMB0098). The strains MC58 and 44/76 (shown here) are meningocin resistant/weakly sensitive. None of these strains are meningocin producers. However, NMB0097 and NMB0098 homologues with open reading frames are found in meningocin producers (N. meningitidis P241 (serogroup A; systemic isolate) and BT878 (serogroup B; carrier isolate), and also in strain FAM18 (serogroup C; ET-37 complex). Knocking out either of the two genes in the strain BT878 yielded mutants that did not secrete meningocin. A similarly disrupted tolC mutant in strain BT878 still released meningocin. Among systemic meningococcal isolates prior to and at the onset (mid-1973 to the end of 1974) of the epidemic peaking in 1975 in North Norway, 12 of 30 (40%) isolates of serogroup A were meningocin producers. However, the rate for serogroup B was 1 of 45 (2.2%). Serogroup B meningocin-resistant/weakly sensitive non-producers dominated in the region from mid-1975 and spread to the rest of the country from then on. No producers were found in selected pharyngeal isolates from healthy carriers collected in Svalbard in the early spring of 1975. Our results suggest that meningocinogeny has played a part in the change from serogroup A to serogroup B among isolates in North Norway during the first half of 1975.
Dietary Patterns, Meat Intake, and the Risk of Type 2 Diabetes in Women (2004)

The Western pattern, especially a diet higher in processed meats, may increase the risk of type 2 diabetes in women.