gebhart/patrepeval huggingface dataset:
OC057: Combined first and second trimester ultrasonic and serological screening for Down's syndrome?including an evaluation of ProMBP as a marker (2003)

During the last two decades the possibilities of non-invasive screening for fetal chromosomal disorders have changed from using maternal age alone as a risk marker to the use of various ultrasonic and biochemical markers in combination with maternal age. Our aim was to estimate the screening performance of different combinations of first and second trimester markers, including a new marker, the proform of eosinophil major basic protein (proMBP). The population comprised 195 singleton pregnancies with a normal outcome enrolled in the Copenhagen First Trimester Study, where a serum sample was available from both the first and second trimester. The performance of different marker combinations was estimated by ROC analysis and Monte Carlo simulation. Using a fixed screen-positive rate (SPR) of 5% the first trimester combined test (nuchal translucency (NT), PAPP-A and free bhCG) yielded a detection rate (DR) of 76%, and the integrated test (NT, PAPP-A, AFP, hCG, uE3 and Inhibin A) a DR of 86%. The best combination yielding a 90% DR was first trimester b-hCG and NT and second trimester proMBP and AFP. ProMBP combined with the triple test increased the DR from 62% to 83%, whereas the addition of Inhibin A only increased the DR to 69%. These results suggest that proMBP may be an important new marker in Down's syndrome screening and in particular a good substitute for Inhibin A.
A Real-Time Microwave Camera at 24 GHz (K-Band} (2009)

The objective is to design and build a real-time microwave imaging system (i.e., camera) Microwave imaging offers tremendous potential in many applications: a) Inspection of low-loss composites, radomes, etc.; b) Detection and evaluation of corrosion under paint; c) Security, contraband detection. Raster scanning is slow and requires bulky mechanical systems. A real-time and portable imaging system can be extremely useful for rapid nondestructive testing of large structures.
Phenytoin‐Induced Seizures: A Paradoxical Effect at Toxic Concentrations in Epileptic Patients (1989)

We examined the incompletely defined convulsant action of phenytoin (PHT) at toxic concentrations in humans. A retrospective chart review (1979-1985) yielded 96 cases (90 patients), meeting both clinical and laboratory criteria for PHT intoxication. Seven patients, all with epilepsy, had one or more seizures while toxic. However, in only two patients (2.1%) with serum concentrations of 93.2 and 69.7 micrograms/ml was a causal relationship deemed highly probable. Seizures did not occur in most toxic epileptic patients with total serum PHT concentrations as high as 85.1 micrograms/ml or in any of the nonepileptic patients with concentrations as high as 64.2 micrograms/ml. The lack of convulsant action of PHT in these patients suggests that seizure risk may be multifactorial and also that PHT is a weak convulsant. We conclude that PHT at very high concentrations can rarely exacerbate seizures or even precipitate generalized status in some epileptic patients, a paradoxical effect.
PCDD and PCDF Emissions from Simulated Sugarcane Field Burning (2006)

The emissions from simulated sugarcane (Saccharum officinarum) field burns were sampled and analyzed for polychlorinated dibenzodioxins and dibenzofurans (PCDDs and PCDFs). Sugarcane leaves from Hawaii and Florida were burned in a manner simulating the natural physical dimensions and biomass density found during the practice of preharvest field burning. Eight composite burn tests consisting of 3-33 kg of biomass were conducted, some with replicate samplers. Emission factor calculations using sampled concentration and measured mass loss compared well to rigorous carbon balance methods commonly used in field sampling. The two sources of sugarcane had distinctive emission levels, as did tests on separate seasonal gatherings of the Florida sugarcane. The average emission factor for two tests of Hawaii sugarcane was 253 ng toxic equivalents (TEQ)/kg of carbon burned (ng TEQ/kg(Cb)) (rsd = 16%) and for two gatherings of Florida sugarcane was 25 ng TEQ/kg(Cb) (N = 4, rsd = 50%) and 5 ng TEQ/kg(Cb) (N = 2, rsd = 91%). The Hawaii sugarcane, as well as most of the Florida sugarcane, had emission values which were well above the value of 5 ng TEQ/kg(Cb) commonly attributed to biomass combustion. Application of this emission factor range to the amount of U.S. sugarcane fields burned suggests that this practice may be a relatively minor source of PCDDs and PCDFs in the U.S. national inventory, but the limited sample size and range of results make this conclusion tenuous.
ChemInform Abstract: SYNTHESIS OF α‐CYANOENAMINES BY CYANATION OF α‐BROMOIMMONIUM BROMIDES AND DEHYDROBROMINATION OF β‐BROMO‐α‐(DIALKYLAMINO)NITRILES (1984)

Abstract Durch Kondensation der Aldehyde (I) mit den sek. Aminen (II) werden nach literaturbekannter Methode die Enamine (III) dargestellt.
Radar applications of 10‐GHZ fiber optic links (1988)

Abstract Long delay lines can improve the performance and flexibility of radar test sets. Using a 2.25‐km‐long fiber optic link, we demonstrated generation of an ideal target for a radar repeater test set and measurement of phase noise closer than 100 Hz to a 9.6‐GHz radar carrier signal using a delay line discriminator phase‐noise test set.
Conformance checking of service behavior (2008)

A service-oriented system is composed of independent software units, namely services, that interact with one another exclusively through message exchanges. The proper functioning of such system depends on whether or not each individual service behaves as the other services expect it to behave. Since services may be developed and operated independently, it is unrealistic to assume that this is always the case. This article addresses the problem of checking and quantifying how much the actual behavior of a service, as recorded in message logs, conforms to the expected behavior as specified in a process model. We consider the case where the expected behavior is defined using the BPEL industry standard (Business Process Execution Language for Web Services). BPEL process definitions are translated into Petri nets and Petri net-based conformance checking techniques are applied to derive two complementary indicators of conformance: fitness and appropriateness . The approach has been implemented in a toolset for business process analysis and mining, namely ProM, and has been tested in an environment comprising multiple Oracle BPEL servers.
[Neocarzinostatin: molecular mechanism of action and prospects for clinical use]. (1982)

This article describes the properties and biological actions of the antitumor protein neocarzinostatin which stands for a whole group of high molecular weight antitumor antibiotics. Special emphasis is given to the development of our understanding of the molecular mechanism of neocarzinostatin action. From this mechanism of action far-reaching perspectives concerning the clinical application of neocarzinostatin are discussed.
On-line electrochemistry/thermospray/tandem mass spectrometry as a new approach to the study of redox reactions: the oxidation of uric acid (1989)

The electrochemical oxidation pathway of uric acid was determined by on-line electrochemistry/thermospray/tandem mass spectrometry. Intermediates and products formed as a result of electrooxidation were monitored as the electrode potential was varied. Several reaction intermediates have been identified and characterized by tandem mass spectrometry. The tandem mass spectrometric results provide convincing evidence that the primary intermediate produced during the electrooxidation of uric acid has a quinonoid diimine structure. The results indicate that once formed via electrooxidation, the primary intermediate can follow three distinct reaction pathways to produce the identified final products. The final electrochemical oxidation products observed in these studies were urea, CO2, alloxan, alloxan monohydrate, allantoin, 5-hydroxyhydantoin-5-carboxamide, and parabanic acid. The solution reactions that follow the initial electron transfer at the electrode are affected by the vaporizer tip temperature of the thermospray probe. In particular, it was found that at different tip temperatures either hydrolysis or ammonolysis reactions of the initial electrochemical oxidation products can occur. Most importantly, the results show that the on-line combination of electrochemistry with thermospray/tandem mass spectrometry provides otherwise difficult to obtain information about redox and associated chemical reactions of biological molecules such as the structure of reaction intermediates and products, as well as providing insight into reaction pathways.
Estimating cancer risk from dental cone-beam CT exposures based on skin dosimetry (2014)

The aim of this study was to measure entrance skin doses on patients undergoing cone-beam computed tomography (CBCT) examinations, to establish conversion factors between skin and organ doses, and to estimate cancer risk from CBCT exposures. 266 patients (age 8-83) were included, involving three imaging centres. CBCT scans were acquired using the SCANORA 3D (Soredex, Tuusula, Finland) and NewTom 9000 (QR, Verona, Italy). Eight thermoluminescent dosimeters were attached to the patient's skin at standardized locations. Using previously published organ dose estimations on various CBCTs with an anthropomorphic phantom, correlation factors to convert skin dose to organ doses were calculated and applied to estimate patient organ doses. The BEIR VII age- and gender-dependent dose-risk model was applied to estimate the lifetime attributable cancer risk. For the SCANORA 3D, average skin doses over the eight locations varied between 484 and 1788 µGy. For the NewTom 9000 the range was between 821 and 1686 µGy for Centre 1 and between 292 and 2325 µGy for Centre 2. Entrance skin dose measurements demonstrated the combined effect of exposure and patient factors on the dose. The lifetime attributable cancer risk, expressed as the probability to develop a radiation-induced cancer, varied between 2.7 per million (age >60) and 9.8 per million (age 8-11) with an average of 6.0 per million. On average, the risk for female patients was 40% higher. The estimated radiation risk was primarily influenced by the age at exposure and the gender, pointing out the continuing need for justification and optimization of CBCT exposures, with a specific focus on children.
Remote femtosecond laser induced breakdown spectroscopy (LIBS) in a standoff detection regime (2006)

The need for robust, versatile, and rapid analysis standoff detection systems has emerged in response to the increasing threat to homeland security. Laser Induced Breakdown Spectroscopy (LIBS) has emerged as a novel technique that not only resolves issues of versatility, and rapid analysis, but also allows detection in settings not currently possible with existing methods. Several studies have shown that femtosecond lasers may have advantages over nanosecond lasers for LIBS analysis in terms of SNR. Furthermore, since femtosecond pulses can travel through the atmosphere as a self-propagating transient waveguide, they may have advantages over conventional stand-off LIBS approaches<sup>1</sup>. Utilizing single and multiple femtosecond pulse laser regimes, we investigate the potential of femtosecond LIBS as a standoff detection technology. We examine the character of UV and visible LIBS from various targets of defense and homeland security interest created by channeled femtosecond laser beams over distances of 30m or more.
Opposing effects ofestradiol andprogesterone onoxytocin receptors inrabbit uterus (1978)

ABSTRACT Estradiol-17# administration to young (10-to 12-week-old) rabbits to produce the estrogen-dominateduterus increased theuterine contractile responseto both oxj- tocin andmethacholine in vitro. In progesterone-dominatel uteri, obtained fromrabbits that received progesterone for 4days after estrogen pretreatment, the contractile response tooxytocin in vitro was selectively abolished; the response tomethacholinewasunaffected. Parallel changeswereobservedintheconcentration(butnotaffinity)ofspecificsites inuterinemicrosomalmembranesthatbind 1111oxytocin withselectivityfeaturesexpectedforoxytocinreceptors.Thus,estrogen-domi-nateduterihaveanincreasednumberofspecific[3H]oxytocinbindingsites permgofmembraneproteinrelativetountreatedcontrols, whereas s ecific oxytocin bindingsites are reduced to barelydetectablelevelsintheprogesterone-dominateduterus.Similarresults areobtainedwhen binding sites aremeasured in membranes from the myometriumof estrogen- or proges-terone-dominated uteri. Short-term (24-hr) progesterone ad-ministrationtoestrogen-pretreatedrabbitsdecreased,butdidnot abolish, specific
Synthesis, photophysics and electrochemistry of novel, nitrogen-containing heterocyclic derivatives (2013)

A series of new π-conjugated donor (thienyl – T) and acceptor (A) oligomers were prepared by Stille coupling reaction. The T–A oligomers consisting of thiophene/bithiophene as donors and 1,2,4-triazine as an acceptor were prepared to investigate their photophysical and electrochemical properties. These compounds were spectroscopically confirmed to be highly conjugated. These UV-vis data show that the number and position of the thiophene considerably affect the width of the HOMO–LUMO gap and the rigidity of the conjugated system. Compounds A2TA, A3TA, A4TA show photoluminescence in a range 466–543 nm.
Synthesis of Tin Oxide (SnO<sub>2</sub>) by Precipitation (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
The Infectious Pathogenesis of Prostate Cancer (2008)

Abstract : Accumulating evidence points to a role of chronic inflammation in the pathogenesis and progression of cancers, including prostate. Infections are important agents in the genesis of inflammation. For prostate cancer, several lines of evidence point to a role of infections as important agents, although no specific infection has consistently been identified. In this project, we are examining two specific infectious agents with respect to prostate cancer: T vaginalis, the most common non-viral sexually transmitted infection, and the recently identified retrovirus XMRV. The aims of this study are 1-) To assess the role of the newly identified XMRV virus in prostate carcinogenesis and progression; 2-) To characterize the role of the infectious protozoa T. vaginalis in prostate carcinogenesis and progression. The current study is nested within the Swedish Watchful Waiting Cohort, a population-based cohort of 1,256 Swedish men diagnosed with localized prostate cancer. During 28 years of follow-up, 320 men have died of cancer, and thus this is a powerful population in which to examine determinants of prostate cancer progression. A tumor repository from archival tissue specimens have been collected from all men in the cohort and will be used to assay for presence of the infections.
Structure Formation in Bis(terpyridine) Derivative Adlayers:  Molecule−Substrate versus Molecule−Molecule Interactions (2007)

The influence of the substrate and the deposition conditions-vapor deposition versus deposition from solution-on the structures formed upon self-assembly of deposited bis(terpyridine) derivative (2,4'-BTP) monolayers on different hexagonal substrates, including highly oriented pyrolytic graphite (HOPG), Au(111), and (111)-oriented Ag thin films, was investigated by high-resolution scanning tunneling microscopy and by model calculations of the intermolecular energies and the lateral corrugation of the substrate-adsorbate interaction. Similar quasi-quadratic network structures with almost the same lattice constants obtained on all substrates are essentially identical to the optimum configuration expected from an optimization of the adlayer structure with C-H...N-type bridging bonds as a structure-determining factor, which underlines a key role of the intermolecular interactions in adlayer order. Slight distortions from the optimum values to form commensurate adlayer structures on the metal substrates and the preferential orientation of the adlayer with respect to the substrate are attributed to the substrate-adsorbate interactions, specifically, the lateral corrugation in the substrate-adsorbate interaction upon lateral displacement and rotation of the adsorbed BTP molecules. The fact that similar adlayer structures are obtained on HOPG under ultrahigh vacuum conditions (solid|gas interface) and on HOPG in trichlorobenzene (solid|liquid interface) indicates that the intermolecular interactions are not severely affected by the solvent.
Warp: A Hardware Platform for Efficient Multimodal Sensing With Adaptive Approximation (2020)

In this article, we present Warp, the first open hardware platform designed explicitly to support research in approximate computing. Warp incorporates 21 sensors, computation, and circuit-level facilities designed explicitly to enable approximate computing research, in a 3.6 cm × 3.3 cm × 0.5 cm device. Warp supports a wide range of precision and accuracy versus power and performance tradeoffs.
Case report: GATA-2 deficiency and secondary alveolar proteinosis (AP) (2016)

After suffering from various infections (mainly pneumonias) since 2007, in 2014 GATA-2 deficiency was diagnosed in a middle-aged female patient (pt).
Abstract P319: Comparing Coronary Artery Calcium among U.S. South Asians with Four Racial/Ethnic Groups: The MASALA and MESA Studies (2014)

Background: South Asians (individuals from India, Pakistan, Bangladesh, Nepal, and Sri Lanka) have high rates of cardiovascular disease (CVD) which cannot be fully explained by traditional risk factors. We created a community-based cohort of South Asians (MASALA) and compared the prevalence of coronary artery calcium (CAC) to four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: We compared 803 South Asians to the four racial/ethnic groups (2,622 Whites, 1,893 African Americans, 1,496 Latinos and 803 Chinese Americans), all free of CVD. We created pooled multivariate Poisson models to examine the effect of race/ethnicity with CAC after adjusting for sex, age, clinical site, education, smoking, BMI, diabetes, hypertension, HDL-, LDL-cholesterol, and cholesterol lowering medication use. Results: The age-adjusted prevalence of any CAC was similar between White and South Asian men (68%), but was lower in Latino (58%), Chinese American (58%) and African American men (51%). South Asian women had similar CAC prevalence as other ethnic minority women but significantly lower than White women (37% vs. 43%, p<0.05). The figure shows the mean CAC scores among each of the five racial/ethnic groups by 5-year increments in age. After adjusting for all covariates, South Asian men were similar to White men and had higher CAC scores compared to African Americans, Latinos and Chinese Americans. In fully adjusted models, CAC scores were similar for South Asian women compared to all MESA groups. However, South Asian women ≥70 years had a higher prevalence of any CAC than all other racial/ethnic groups. Conclusions: South Asian men are more similar to Whites than the other race/ethnic groups in MESA. The high burden of subclinical atherosclerosis in South Asians may partly explain higher rates of CVD in South Asians. Follow-up data from the MASALA study will determine whether CAC is associated with incident CVD among South Asians and if this relationship differs from that observed in other racial/ethnic groups.
Essays in brewing science (2007)

Qualities.- Proteins.- pH.- Color.- Foam.- Haze.- Microbiology.- Inorganic Ions.- Processes.- Raw Materials.- Modification.- Enzymes.- Yeast.- Oxygen.- Water and Energy.- Sanitation and Quality.
Simultaneous Occurrence of Acute Myeloblastic Leukaemia and Multiple Myeloma without Previous Chemotherapy (1974)

The simultaneous detection of multiple myeloma and acute myeloblastic leukaemia is reported in two patients who had not undergone chemotherapy. Histological examinations confirmed the infiltration by both myeloblasts and plasma cells. Only the latter contained monoclonal immunoglobulin chains at immunofluorescent studies. The possible relation between the two distinct proliferative processes is briefly discussed.
Analysis of Subpixel Registration Accuracy (1983)

Geometric and probabilistic models for subpixel accuracy are developed. The geometric models bound the error in offset estimation using the pixels in an observed digital straight line. One probabilistic model bounds the estimate of error offset for continuous images. The other model bounds the error for discrete images given that one is in the correct pixel.
Ethnic differences in Internal Medicine referrals and diagnosis in the Netherlands (2008)

These findings demonstrate substantial ethnic differences in the use of the outpatient care facilities. Ethnic differences may decrease in the future when the proportion of first-generation immigrants decreases. The increased use of outpatient health care seems to be related to ethnic background and the generation of the immigrants rather than to socio-economic status. Further study is needed to establish this.
Extensive and progressive eruption in a young woman (2010)

Journal Article Extensive and progressive eruption in a young woman Get access O. Abbas, O. Abbas Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon Search for other works by this author on: Oxford Academic Google Scholar N. Rubeiz, N. Rubeiz Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon Search for other works by this author on: Oxford Academic Google Scholar S. Ghosn S. Ghosn Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon Dr Samer Ghosn, Department of Dermatology, American University of Beirut Medical Center, Riad El Solh St, PO Box 11‐0236, Beirut, LebanonE‐mail: sg03@aub.edu.lb Search for other works by this author on: Oxford Academic Google Scholar Clinical and Experimental Dermatology, Volume 35, Issue 3, 1 April 2010, Pages e85–e86, https://doi.org/10.1111/j.1365-2230.2009.03547.x Published: 01 April 2010
EVALUATION OF HYDROPHOBICITY AND ANTITUMOR ACTIVITY OF A MOLECULE LIBRARY OF MANNICH KETONES OF CYCLOALKANONES (2002)

A series of Mannich ketones of cycloalkanones were synthesized to study the relative importance of structure and specific substitutions in relation to their hydrophobicity and antitumor activity. Substitutions were carried out with morpholinyl, pirrolidinyl, piperidyl, and tetrahydro-isoquinolyl groups in various position on four different base structures. Hydrophobicity of Mannich ketones was characterized by chromatography data (log k′) and by software calculated parameters (c log P). Cell proliferation inhibitory activity of cycloalkanones was evaluated by MTT and apoptosis assays on A431 human adenocarcinoma cells. Our results suggest that the higher the hydrophobicity values (log k′ and c log P) the higher the antitumor- and apoptotic activity of Mannich ketones. Determination of hydrophobicity by measuring the log k′ or by calculating the c log P values of the compounds may help to predict their biological activities.