gebhart/patrepeval huggingface dataset:
The regulation of the cell cycle during <i>Drosophila</i> embryogenesis: the transition to polyteny (1991)

The process of polytenization plays a crucial role in Drosophila development, and most of the larval tissues are polytene. By analyzing the pattern of DNA replication in embryos pulse-labeled with BrdU, we show that many larval tissues undergo a transition to begin becoming polytene late in embryogenesis. Our results demonstrate that in these larval tissues polyteny results from a modified cell cycle, the endo cell cycle, in which there is only an S (synthesis) phase and a G (gap) phase. A key regulator of the mitotic cell cycle, the product of the string gene (the Drosophila homologue of cdc25), is not required for the endo cell cycle. The developmental regulation of the endo cell cycle is striking in that tissue-specific domains undergo polytene DNA replication in a dynamic pattern at defined times in embryogenesis. During subsequent rounds of the endo cell cycle in late embryogenesis and first instar larval development, the domains are subdivided and the temporal control is not as rigid. The length of the G phase varies among different tissues. By quantifying DNA content, we show that during the early polytene S phases the genome is not fully duplicated.
De las necesidades del cliente al ensamblaje. GEDAS, fábricas de software (1998)

Elevated levels of myeloid-related protein (MRP)-8/14 (S100A8/A9) are associated with first cardiovascular events in healthy individuals and worse prognosis in patients with acute coronary syndrome (ACS). The diagnostic utility of MRP-8/14 in patients presenting to the emergency room with symptoms concerning for ACS is uncertain. MRP-8/14 was measured in serial serum and plasma samples in a single center prospective cohort-study of patients presenting to the emergency room with non-traumatic chest pain concerning for ACS. Final diagnosis was adjudicated by an endpoint committee. Of patients with baseline MRP-8/14 results (n = 411), the median concentration in serum was 1.57 μg/ml (25th, 75th: 0.87, 2.68) and in plasma was 0.41 μg/ml (<0.4, 1.15) with only moderate correlation between serum and plasma (ρ = 0.40). A final diagnosis of MI was made in 106 (26%). Peak serum MRP-8/14 was higher in patients presenting with MI (p < 0.001). However, the overall diagnostic performance of MRP-8/14 was poor: sensitivity 28% (95% CI 20-38), specificity 82% (78-86), positive predictive value 36% (26-47), and negative predictive value 77% (72-81). The area under the ROC curve for diagnosis of MI with MRP-8/14 was 0.55 (95% CI 0.51-0.60) compared with 0.95 for cTnI. The diagnostic performance was not improved in early-presenters, patients with negative initial cTnI, or using later MRP-8/14 samples. Patients presenting with MI had elevated levels of serum MRP-8/14 compared to patients with non-cardiac chest pain. However, overall diagnostic performance of MRP-8/14 was poor and neither plasma nor serum MRP-8/14 offered diagnostic utility comparable to cardiac troponin.
A Framework for Sign Language Sentence Recognition by Commonsense Context (2007)

This correspondence proposes a complete framework for sign language recognition that integrates a commonsense engine in order to deal with sentence recognition. The proposed system is based on a multilevel architecture that allows modeling and managing of the knowledge of the recognition process in a simple and robust way. The final abstraction level of this architecture introduces the semantic context and the analysis of the correctness of a sentence given in a sequence of recognized signs. Experimentations are presented using a set of signs from the Italian sign language (LIS) for domotic applications. The implemented system maintains a high recognition rate when the set of signs grows, correcting erroneously recognized single signs using the sentence context.
Deciding type equivalence in a language with singleton kinds (2000)

Work on the TILT compiler for Standard ML led us to study a language with singleton kinds: S(A) is the kind of all types provably equivalent to the type A. Singletons are interesting because they provide a very general form of definitions for type variables, allow fine-grained control of type computations, and allow many equational constraints to be expressed within the type system.
Super Class-AB Recycling Folded Cascode OTA (2018)

A super class-AB version of the recycling folded cascode (RFC) operational transconductance amplifier (OTA) is proposed. The use of an adaptive bias circuit for the input differential pair provides dynamic current boosting and increased gain-bandwidth product (GBW). Moreover, use of local common-mode feedback (LCMFB) at the load of the differential pair further improves these performance parameters and provides high current efficiency. Measurement results of a test chip prototype fabricated in a 0.5-μm CMOS process show an increase in slew rate and GBW by a factor of 34 and 3, respectively, versus the conventional RFC OTA using the same supply voltage and bias currents. Overhead in other performance metrics is small.
Quality of life in functional dyspepsia: responsiveness of the Nepean Dyspepsia Index and development of a new 10‐item short form (2001)

The Nepean Dyspepsia Index is a responsive disease-specific quality-of-life measure; the 10-item short form can be applied in clinical trials of functional dyspepsia.
Un Algoritmo ACS con Seleccion Dinamica de Movimiento y Operador 2-Opt (2002)

La metaheuristica Ant Colony Optimization (ACO) (Dorigo y Di Caro, 1999) es uno de los nuevos paradigmas que permiten la resolucion de problemas combinatorios del tipo NP. En este articulo se presentan los resultados obtenidos al aplicar un algoritmo variante de la metaheuristica ACO, llamado Ant Colony System (ACS) (Dorigo y Stuzle, 1999; Pavez et al., 2000) complementado con un operador de eliminacion de cruces (2-Opt), en torno al mundialmente conocido Traveling Salesman Problem (TSP) (Reinelt, 1994). Se presentan nuevos tours solucion con mejores resultados que los logrados hasta hoy y se discuten las oportunidades de desarrollo futuro.
BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy (2020)

Bruton's tyrosine kinase (BTK) signaling is involved in innate immune responses and regulates the production of proinflammatory cytokines that can contribute to COVID-19 immunopathology. Clinical trials with BTK inhibitors in COVID-19 treatment have been proposed, and previous studies have attempted to investigate the therapeutic effects of ibrutinib and underlying mechanisms in treating viral pneumonia. These attempts, however, did not consider potential off target effect of BTK inhibitors on T cell differentiation, function, and survival, which may be beneficial in treatment for COVID-19. Here, we summarize the current knowledge of BTK/IL-2-inducible T-cell kinase (ITK) signaling in immunopathology and lymphopenia and discuss the potential of BTK/ITK dual inhibitors such as ibrutinib in modulating immunopathology and lymphopenia, for COVID-19 therapy.
Radiation-dependent hot-carrier effects (1986)

The effect of ionizing radiation on hot-carrier degradation for n-channel MOSFET's has been investigated. It has been experimentally found that hot-carrier degradation for these devices increases after exposure to ionizing radiation. Exposure can be deliberate or occur during device fabrication. The cause of the enhanced degradation has been attributed to radiation-induced trap states.
A Review of New Time-to-Digital Conversion Techniques (2019)

Time-to-digital converters (TDCs) are vital components in time and distance measurement and frequency-locking applications. There are many architectures for implementing TDCs, from simple counter TDCs to hybrid multi-level TDCs, which use many techniques in tandem. This article completes the review literature of TDCs by describing new architectures along with their benefits and tradeoffs, as well as the terminology and performance metrics that must be considered when choosing a TDC. It describes their implementation from the gate level upward and how it is affected by the fabric of the device [field-programmable gate array (FPGA) or application-specific integrated circuit (ASIC)] and suggests suitable use cases for the various techniques. Based on the results achieved in the current literature, we make recommendations on the appropriate architecture for a given task based on the number of channels and precision required, as well as the target fabric.
Macro-femto inter-cell interference mitigation for 3GPP LTE-A downlink (2012)

In LTE-A or Rel. 10+, heterogeneous network deployments are supported to improve the user experienced link performance. However, such deployments give rise to new interference problems. In this study, macro-femto-cell interference scenarios for LTE-A downlink are investigated. We focus on the critical interference scenario of colliding cell-specific reference signals (CRSs). As conventional receivers with channel estimation based on the interfered CRSs fail to work properly, we present advanced interference mitigation schemes for user equipment (UE), such as the received-power dependent interference cancellation (IC), decision-directed channel estimation and IC-assisted channel estimation. Numerical simulation results showed that the proposed schemes are able to significantly reduce the inter-cell interference so that high throughput can be ensured even under the harsh macro-femto interferences.
Speciation as automatic categorical modularization (1997)

Many natural and artificial systems use a modular approach to reduce the complexity of a set of subtasks while solving the overall problem satisfactorily. There are two distinct ways to do this. In functional modularization, the components perform very different tasks, such as subroutines of a large software project. In categorical modularization, the components perform different versions of basically the same task, such as antibodies in the immune system. This second aspect is the more natural for acquiring strategies in games of conflict, An evolutionary learning system is presented which follows this second approach to automatically create a repertoire of specialist strategies for a game-playing system. This relieves the human effort of deciding how to divide and specialize. The genetic algorithm speciation method used is one based on fitness sharing. The learning task is to play the iterated prisoner's dilemma. The learning system outperforms the tit-for-tat strategy against unseen test opponents. It learns using a "black box" simulation, with minimal prior knowledge of the learning task.
Single chip FMCW radar for target velocity and range sensing applications (2003)

A novel low-power frequency-modulated continuous-wave (FMCW) radar MMIC (monolithic microwave integrated circuit) chip has been demonstrated. It incorporates an electronic circulator in order to allow single antenna operation in miniature low-cost applications. All the microwave functions necessary for an FMCW radar operating at C-band are integrated on a single GaAs integrated circuit, including VCO, buffer amplifier, mixer, and the electronic circulator. The chip dimensions are 1.08*2.15*0.25 mm. The high level of integration is achieved by means of a low-cost 1- mu m MESFET foundry process without the use of via hole grounding. Self-bias circuitry is included on chip so that a single positive power supply is required. Potential applications include miniature range and velocity discriminating fuzes, sensors and alarms, and altimeter circuits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
In Search of Shareholder Value: Managing the Drivers of Performance. (1997)

Shareholder value can no longer be seen as the latest craze in the corporate classroom. It's grown up. It's redefining the syllabus by which we learn to profit or perish. It has moved into the mainstream of global corporate life where would-be winners can no longer afford to ignore it.Drawing on the experience of PricewaterhouseCoopers' worldwide network of companies and clients, this new edition of a best-selling title will provide you with the key to unlocking the secrets to real wealth creation. The impact of the information revolution, the integration of capital markets, and the increased ability of investors to compare and contrast corporate performance has put shareholder value high on the corporate agenda. These days, investors injecting money into your company are looking for a financial return as good as, if not better than, if they had invested in any other. Today's businesses need to maximize value for their shareholders or watch their share price plummet as investors vote with their feet and transfer their money and their trust into competitors' hands. Benefits In Search of Shareholder Value explains the concept of shareholder value and shows how it can help companies and their managers make better, more informed, and proactive decisions. It looks at the philosophy of value creation and at the global financial environment in which value-based management can thrive, and it transforms the insights of market analysts into management tools that can be used throughout the company to add genuine improvements to performance. The book covers every aspect of learning how to deliver value to your investors, including:* introducing the basic concepts of shareholder value * analyzing the theory and history behind shareholder value * establishing the true cost of your capital * the market's preference for judging performance on cash flow rather than profit and loss * how shareholder value is being applied within emerging economies. * principels of value-based management
Industry standards catch up with in-service welding (1999)

Welding onto a pipeline after it has been put into service, a practice commonly referred to as hot tap welding, is frequently required for several reasons. Repair sleeves are installed to reinforce areas of corrosion or mechanical damage, and branch connections are made for system modifications. There are often significant economic incentives to perform this welding without removing the system from service. Operations are maintained during welding and the pipe's contents are not vented into the atmosphere. Due to technological advances in in-service welding, industry needed an update to standards and recommended practices. This year, the American Petroleum Institute (API) hopes to meet that need. The 19th edition of API Standard 1104--Welding of Pipelines and Related Facilities, includes a new appendix that pertains to in-service welding. Appendix B, In-Service Welding, is intended to eventually replace API Recommended Practice 1107--Pipeline Maintenance Welding Practices. API 1107, which was introduced in 1966 and updated in 1987 and 1991, is intended to provide recommended practices for pipeline maintenance welding. The current third edition approached its mandatory five-year review in 1996 by the API-AGA Joint Committee on Oil and Gas Pipeline Field Welding Practices, which also maintains API 1104. The committee saw 11078 needed tomore » reflect the updates that had been made to 1104 as well as the technological advances for in-service welding. To alleviate redundancy between the two documents, and to alleviate lag time between updates, the committee approved a proposal to update and incorporate requirements of API 1107 into an appendix of API 1104. In the meantime, the third edition of API 1107 was reapproved for another five-year review cycle.« less
APPLICATION OF METHODS OF ASSOCIATED PETROLEUM GAS UTILIZATION FOR THE EASTERN SIBERIA (2016)

The article considers the most effective and environmentally friendly methods of utilization of associated petroleum gas (APG) for advanced oil and gas companies, as well as the developed method of utilization of associated gas using downhole steam-gas generator. The downhole steamgas generator burns APG at the bottomhole in the combustion chamber, and the combustion products - nitrogen and carbon dioxide - are supplied to the oil reservoir. A method for calculating the theoretical amount of air and combustion products is proposed.
EQUIPMENT FOR THE CONTINUOUS SAMPLING OF EXPIRED C-14 CARBON DIOXIDE FROM ANIMALS IN A RESPIRATION CHAMBER (1970)

not available
Smart adjuvants (2007)

Although vaccine adjuvants have been used for almost a century, alum is the only adjuvant licensed by the US FDA for human vaccine use. Many adjuvants studied to date have generalized inflammatory properties and lack specificity in terms of targeting immune compartments and cell populations. Indeed, such adjuvants have often been crude in formulation, their effects usually restricted to T-helper 2-type immunity and their use limited owing to inherent toxicity. However, recent advances in immunology have resulted in a number of potential adjuvant candidates that are able to modulate the immune response in a more controlled and specific manner. These novel adjuvants are attractive for inclusion in current and future vaccine strategies since they have better-defined mechanisms of action. In this article, we review several compounds that target specific immune components, such as cells, receptors or signaling pathways, and have termed such reagents 'smart adjuvants'.
The Effect of Aerobic Dance on Bone Density in Climacteric Women (1999)

The purpose of this study was to investigate the effects of aerobic dance on bone density in climacteric women. Climacteric women aged 40 to 55 years were enrolled to this study. They were divided into aerobic dance group(N=8)and control group(N=8), experienced for 16 weeks. Aerobic dance group has the intensity from 40% to 85% of maximal heart rate. Aerobic dance group increased the ward triangle, lumbar 2-4 and osteocalcin but decreased femur trochant, femur neck. Control group increased the femur trochant, femur neck and ward trianagle but decreased lumbar 2-4, osteocalcin. Aerobic dance treatment of 16weeks tended to increase bone density of climacteric women but was of no effect of increasing of bone density, because aerobic dance treatment which consisted of articulation exercise was not proper for mechanics stress of weight. Then, for density aerobic dance with muscles exercise which weight down to the body than this do less density aerobic dance with muscles exercise which weight down to the body than this aerobic dance, and, differently to the exercise effect of another part of body, The effect of aerobic dance for bone density is expected to do the longer aerobic dance. It is important structure that our bone prop our body. Then the integrety of bone density diminished its own density after one`s age of 30s even people two. When bone density diminished if a woman who had menopause have dropped her bone density. It would be lack of woman`s known as estrogen(16,17). It is determined to gage human`s bone density that different from young woman and old woman bone structure(4). Generally speaking the woman is more likly to have a osteoporoses than the man, 70~80% of elapsed the age of 50s human have a osteoporoses all we are concerned with osteoporoses high(6). It can be a osteoporoses to a woman of 3~5% at first time her menstruation period. It is diminished woman`s bone density after ten years from her first menstruation . One third of woman had a defficiency of bone density because most woman less have a mount of bone than most man have affect of hormon, less activated movement less production of estrogen be operated by ovary erased treatment etc(14). As terminated the dangerous thing in the individuality and environment, it can diminish woman`s of osteoporoses. It can be recovery the woman`s bone density through the treatment of low calcium but it can`t be recovery its heredity. So one must manage their health statement continually(10). O`connell(1996) said that the only thing which treat a lack of bone is a aerobic dance especially. Nkansah(1993) said that the main causual osteoporosis is enviromental and hereditical one enviromental cause of osteoporoses is lack of eating calcium or regular dance(1,2,3,5,9,11,12,13,15,18).
The roles of APOBEC3B in gastric cancer. (2015)

Gastric cancer was the third cause of death in China. In this study, we found that the APOBEC3 (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3) expression was higher in gastric cancer tissues than that in normal tissues and confirmed APOBEC3B expression was correlated with the unfavorable prognosis of the patients with gastric cancer. Furthermore, APOBEC3B expression was associated with gender, tumor size, histological grade, T stage, and TNM staging of the patients with gastric cancer. Down-regulation of APOBEC3B expression in MNK28 cells could enhance the cytotoxicity of PDCD2. No editing took place in PDCD2 positive MKN28 cells with APOBEC3B shRNA. These results indicated that loss of function of PDCD2 may be partly caused by APOBEC3B-induced extensive mutagenesis.
Effect of Temperature on Stereoregularity and Rate of Polymerization of Methyl Methacrylate with Grignard Reagent, RMgBr. (1961)

RMgBrよりなるグリニャール試薬によって,重合温度を-78℃より+20℃まで変えて重合すると,重合速度はある重合温度において最高となる。得られた重合体の赤外線スペクトルから,重合体中のisotactic%とsyndiotactic%とをそれぞれ阿部およびBaumannの方法によって求めた。RMgBrのRが短かい直鎖のとき,またはフェニルのときは,isotactic%は重合温度の上昇とともに増加し,syndiotactic%は減少する。室温になるとフェニルのときはisotactic%が100%になるが,それ以外のRのときは100%にならない。一方,Rが枝分れした鎖,n-オクチルのときは,isotactic%は重合温度によらず常に100%であった。
The analysis of Clock Synchronization Protocol on Ethernet (2011)

The synchronization is a key point in measurement and control systems, which use technologies such as network communication, local computing and distributed objects. Modern industrial application is demanding the synchronization for higher precision, this paper analyzes a variety of synchronous time synchronization protocols used in the current industrial Ethernet applications, mean-while explains the applications and characteristics. The main point of the paper focuses on the precise time synchronization (PTP) protocol of IEEE 1588 standard, as well as some suggestions for better performance.
Cloud integration &#x2014; Strategy to connect applications to cloud (2013)

Cloud Computing is being widely hailed path by enterprises to realize benefits without compromising control. However, enterprises concern is the integration of applications hosted both on premise, Cloud and partner environments. In spite of enterprise's strategic imperatives to meet their business goals by building integration services between these environments, new integration challenges are posed with the advent of areas like Cloud, Social, and Mobile that are augmenting to the existing complexity. The key challenges being Performance and Usability of these services which cut across Legacy, On Premise, Cloud applications and SaaS applications. Enterprises are spending highly on these integrations as these are crucial for their business process to be executed seamlessly. Key Patterns w.r.t Enterprises Integration considering the widely adopted Cloud scenario are: On-Premise Application to Cloud Application Integration: Cloud Application to On-Premise Application Integration: Cloud to Cloud Application Integration: B2B Integration: Web API Publishing This paper helps in adoption of an efficient integration strategy to connect applications on cloud with effective cost benefits and lowered total cost of ownership (TCO).
Fundamentals of Modern Allergy (1960)

viruses, but it does mean that we should make the most of the practical clinical methods available to all trained physicians. Doesn't the prospect of better understanding respiratory disease sound like it would add to the enjoyment of practice? Don't the demands of a third of your practice justify the modest expenditure of the price of two office visits plus an evening of study? From the technical standpoint there is much to recommend this volume. It is authoritative, well written, well organized, easily read, and as up-to-date as the Reoviruses. The references are pertinent, the illustrations and printing excellent. This work represents the product of years of intensive interest in the field by