gebhart/patrepeval huggingface dataset:
Excretion of conjugated 2-amino-3-hydroxyacetophenone by man, and its significance in tryptophan metabolism (1955)

Research Article| October 01 1955 Excretion of conjugated 2-amino-3-hydroxyacetophenone by man, and its significance in tryptophan metabolism C. E. Dalgliesh C. E. Dalgliesh 1Postgraduate Medical School, Ducane Road, London, W. 12 Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1955) 61 (2): 334–337. https://doi.org/10.1042/bj0610334 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation C. E. Dalgliesh; Excretion of conjugated 2-amino-3-hydroxyacetophenone by man, and its significance in tryptophan metabolism. Biochem J 1 October 1955; 61 (2): 334–337. doi: https://doi.org/10.1042/bj0610334 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1955 CAMBRIDGE UNIVERSITY PRESS1955 Article PDF first page preview Close Modal You do not currently have access to this content.
Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from <i>Ganoderma tsugae</i> in A549 human lung adenocarcinoma cell line (2006)

Telomerase expression is the hallmark of tumor cells, and activation of this ribonucleoprotein complex may be a rate-limiting or critical step in cellular immortalization and oncogenesis. Fungal immunomodulatory protein, FIP-gts, has been isolated from Ganoderma tsugae. In the present study, we expressed and purified the recombinant fungal immunomodulatory protein reFIP-gts in E. coli. We found that reFIP-gts significantly and selectively inhibits the growth of A549 cancer cells while not affecting the growth of normal MRC-5 fibroblasts. The reFIP-gts suppression of telomerase activity is concentration-dependent, due to the downregulation of the telomerase catalytic subunit (hTERT). It also happens at the mRNA level. These results were confirmed by transient transfections of A549 cells with pGL3-Basic plasmid constructs containing the functional hTERT promoter and its E-box-deleted sequences cloned upstream of a luciferase reporter gene. With electrophoretic mobility shift assays and Western blotting, we demonstrated that in response to reFIP-gts, binding of c-myc transcriptional factor to the E-box sequence on the hTERT promoter is inhibited. These results show that reFIP-gts suppresses telomerase activity and inhibits transcriptional regulation of hTERT via a c-myc-responsive element-dependent mechanism. Our findings provide new insight into both the anticancer function of reFIP-gts and the regulation of hTERT/telomerase expression, which may be valuable in the development of a promising chemopreventive agent.
Pilot-Plant Investigation of the Leaching Process for the Recovery of Scandium from Red Mud (2002)

A pilot-plant process has been developed based on an innovative laboratory-scale method for the recovery of scandium that exists in economically interesting concentrations in red mud, the main byproduct of alumina production. This method includes acid leaching of the red mud pulp, ion-exchange separation of scandium and lanthanides from the co-leached main elements such as iron, and subsequent liquid−liquid extraction of the eluate for further scandium purification and enrichment. In this work, experimental and theoretical investigation of the pilot-scale leaching process was performed. The following parameters were tested: mode of agitation, solid-to-liquid ratio, acidity of the leachate, number of stages in the process, and pretreatment of red mud with concentrated acids in order to achieve optimum scandium recovery combined with low iron dissolution. Furthermore, by theoretical interpretation of the experimental data, a predictive correlation for the scandium leaching efficiency was developed.
Electric field gradients and charge density in corundum, α-Al<sub>2</sub>O<sub>3</sub> (1982)

The charge density in α-Al2O3 has been refined with respect to X-ray structure factors [complete spheres for both Mo Kα and Ag Kα radiations with (sin θ/λ)max = 1.19 and 1.495 Å-1 respectively] and electric-field gradient tensors at both atomic sites, using Hirshfeld- type deformation functions. Atomic charges from a κ refinement are + 1.32 (5) for Al and -0.88 (8) e for O. The charge distribution of O is polarized towards the four Al neighbours, and metal-metal bonds are clearly absent. Quadrupole coupling constants and asymmetry parameters of the field-gradient tensors cannot be determined from the structure factors. They define the quadrupolar deformations near the atomic centers, and the X-ray data define the charge density between the atoms. The orientational parameters of the tensors and the signs of their largest eigenvalues can be qualitatively retrieved from the X-ray data. The refinement of anisotropic secondary-extinction parameters may, however, destroy this information. Refinement with respect to the field gradients affects mainly the quadrupolar deformation terms, and has little influence on the X-ray scale factor (i.e. monopolar terms) and computed electrostatic fields (i.e. dipolar terms). Properties of the charge density with different angular symmetries are thus only weakly correlated.
The superconducting state of the high-transition temperature superconductors: Experimental basis (1991)

Experiments on the high-T(sub c) cuprate superconductors continue to narrow the possible theoretical explanations of the phenomenon. Experimental evidence to date points to a BCS-like state, with pairs in singlet s-states, the familiar gap in the excitation spectrum, Type 2 behavior in a magnetic field, and a normal state with fermi liquid origins. Several other features of the superconducting state in the cuprates, however, appear to differ from those of conventional alloy superconductors (these relate to the detailed structure of the gap and to the nature of the coupling mechanism). Recent experiments have helped clarify what these differences are, and together with the earlier experiments, they now impose still stronger constraints on theories of these superconductors. These and other developments are reviewed.
Reactions of 1-Substituted 5-Tetrazolyllithium Compounds; Preparation of 5-Substituted 1-Methyltetrazoles (1971)

1-Methyl-5-tetrazolyllithium undergoes fragmentation to nitrogen and lithium methylcyanamide at temperatures exceeding −50°. Below −60° it is however fairly stable and a useful reagent for the preparation of various 5-substituted 1-methyltetrazoles. It reacts readily with halogens, cyanogen bromide, sulfur, aldehydes, ketones, and acid chlorides but not appreciably with benzyl bromide and benzonitrile. With methyl benzoate it forms a labile addition compound which can be hydrolyzed to 5-benzoyl-1-methyl-tetrazole.1-Phenyl-5-tetrazolyllithium rapidly decomposes to lithium phenylcyanamide at temperatures as low as −65° to −70°.
COMPUTATION IN THE PRESENCE OF NOISE (1961)

Two approximate methods are presented for analyzing the effect of noise on computer solutions of differential equations. The computer's operation is assumed to be governed by a difference equation; the input message is a sumed to be an additive mixture of a random signal and the undesired noise. It is shown that a bound may be placed on the effect of this additive noise and, because this bound satisfies a linear timeinvariant difference equation, the stochastic properties of this bound are easily found. The alternate method considers the noise as a small random perturbation of the signal. A linear, time-varying difference equation with random parameters describing the effect of the noise is then obtained. It is shown that both techniques require less computational labor and information about the random properties of the signal and oise than do conventional methods. (Author)
MEASUREMENTS OF THE THERMAL CONDUCTIVITY OF SOILS TO HIGH TEMPERATURES. Final Report. (1969)

t is less than or equal to 3 x 10(-6) leading to the question of the validity of the present renormalization group analysis of transport properties, at least for the case of helium. This anomaly led to closer examination of the boundary effects in the measurements. During the experiments a totally unexpected effect in the very dilute He-3 - He-4 mixtures was observed which led to the explanation of the anomalous results. The concentration dependence of the thermal conductivity near T sub lambda in the superfluid phase was found to deviate strongly from the predictions. The results gave an independent verification of this behavior and caused reanalysis of the Khalatnikov theory of hydrodynamics of the mixtures. An alternative solution was found which is in better agreement with the experiment.
ESTIMATING CHAOS AND COMPLEX DYNAMICS IN AN INSECT POPULATION (2001)

A defining hypothesis of theoretical ecology during the past century has been that population fluctuations might largely be explained by relatively low-dimensional, nonlinear ecological interactions, provided such interactions could be correctly identified and modeled. The realization in recent decades that such nonlinear interactions might result in chaos and other exotic dynamic behaviors has been exciting but tantalizing, in that attributing the fluctuations of a particular real population to the complex dynamics of a particular mathematical model has proved to be an elusive goal. We experimentally tested a model-predicted sequence of transitions (bifurcations) in the dynamic behavior of a population from stable equilibria to quasiperiodic and periodic cycles to chaos to three-cycles using cultures of the flour beetle Tribolium. The predictions arose from a system of difference equations (the LPA model) describing the nonlinear life-stage interactions, predominantly cannibalism. We built a stochastic version of the model incorporating demographic variability and obtained conditional least-squares estimates for the model parameters. We generated 2000 “bootstrapped data sets” with a time-series bootstrap technique, and for each set we reestimated the model parameters. The resulting 2000 bootstrapped parameter vectors were used to obtain confidence intervals for the model parameters and estimated distributions of the Liapunov exponents for the deterministic portion (the skeleton) of the model as well as for the full stochastic model. Frequency distributions of estimated dynamic behaviors of the skeleton at each experimental treatment were produced. For one treatment, over 83% of the bootstrapped parameter estimates corresponded to chaotic attractors, and the remainder of the estimates yielded high-period cycles. The low-dimensional skeleton accounted for at least 90% of the variability in the population abundances and accurately described the responses of populations to experimental demographic manipulations, including treatments for which the predicted dynamic behavior was chaos. Demographic stochasticity described the remaining noise quite well. We conclude that the fluctuations of experimental flour beetle populations are explained largely by known nonlinear forces involving cannibalistic-stage interactions. Claims of dynamic behavior such as periodic cycles or chaos must be accompanied by a consideration of the reliability of the estimated parameters and a realization that the population fluctuations are a blend of deterministic forces and stochastic events.
A circulating-liquid laser system (1968)

A circulating-liquid laser system utilizing Nd in selenium oxychloride is described. An advantage of such a laser is the etticient cooling of the medium. Special components, such as the laser head, circulating pump, and cells compatible with the chemical properties of the medium had to be developed. The system has been operated at I pulse per second with an output of 0.2 joule per pulse with no essential limitations on running time or higher performance capabilities.
[Treatment strategies for inflammatory bowel disease]. (2005)

In patients with active inflammatory bowel disease (IBD), the objective is to achieve clinical remission. For ulcerative colitis (UC), oral or rectal aminosalycilates are widely used, and in more severe flares, corticoids and occasionally ciclosporine. In active Crohn's disease, corticosteroids represent the main treatment; budesonide must be preferred, as this steroid is better tolerated than prednisone. In patients refractory or intolerant to steroids, infliximab or artificial nutrition can be considered. Maintenance treatment is indicated in most of IBD patients. 5-ASA derivates are preferred in UC; in case of failure, azathioprine can be used. In Crohn's disease, azathioprine or methotrexate are more widely used; maintenance with infliximab is an option in case of failure. Surgery is mainly indicated for complications or in patients resistant to medical treatment.
DNA Polymerase δ and ζ Switch by Sharing Accessory Subunits of DNA Polymerase δ (2012)

Translesion DNA synthesis is an important branch of the DNA damage tolerance pathway that assures genomic integrity of living organisms. The mechanisms of DNA polymerase (Pol) switches during lesion bypass are not known. Here, we show that the C-terminal domain of the Pol ζ catalytic subunit interacts with accessory subunits of replicative DNA Pol δ. We also show that, unlike other members of the human B-family of DNA polymerases, the highly conserved and similar C-terminal domains of Pol δ and Pol ζ contain a [4Fe-4S] cluster coordinated by four cysteines. Amino acid changes in Pol ζ that prevent the assembly of the [4Fe-4S] cluster abrogate Pol ζ function in UV mutagenesis. On the basis of these data, we propose that Pol switches at replication-blocking lesions occur by the exchange of the Pol δ and Pol ζ catalytic subunits on a preassembled complex of accessory proteins retained on DNA during translesion DNA synthesis.
Polarisation and dielectric properties of fatigued ferroelectric polymer films (2003)

When ferroelectric materials are subjected to repeated reversal of polarisation, the magnitude of the reversed polarisation is observed to decrease. This phenomenon is referred to as fatigue and is generally ascribed either to space charge effects or to the pinning of domain walls at defects. Polyvinylidene fluoride (PVDF) and its copolymers with trifluoroethylene, in 65/35 and 75/25 mol% proportions were studied. The polymers were fatigued by exposing them to an alternating field with amplitude above the coercive field, while measuring the D-E hysteresis loops. Samples containing only the p crystal form showed a reduction in switched polarisation during the hysteresis loop measurement, while those containing a mixture of the a and p phases did not. In addition, dielectric spectra were measured over the range from 10/sup -2/ Hz to 10/sup +5/ Hz. The major change in the dielectric spectra of the fatigued samples was a reduction in the dielectric loss at the lowest measured frequencies. We speculate that this is due to charge trapping.
News from the Field (1992)

29 let ter a d d re sse d to "staff, friends, and colleagues.
A mechanism of magnetic hysteresis in heterogeneous alloys (1991)

It is suggested that in many ferromagnetic materials there may occur particles distinct in magnetic character from the general matrix, and below the critical size, depending on shape, for which domain boundary formation is energetically possible. For such single-domain particles, change of magnetization can take place only by rotation of the magnetization vector. As the field changes continuously, the resolved magnetization may change discontinuously at critical values of the field. The character of the magnetization curves depends on the degree of magnetic anisotropy of the particle and on the orientation of easy axes with respect to the field. The magnetic anisotropy may arise from the shape of the particle, from magnetocrystalline effects, and from strain. A detailed quantitative treatment is given of the effect of shape anisotropy when the particles have the form of ellipsoids of revolution, along with a less detailed treatment for the general ellipsoidal form.
Intrusion Detection Systems - Analysis and Containment of False Positives Alerts (2010)

The dependence on information technology became critical and IT infrastructure, critical data, intangible intellectual property are vulnerable to threats and attacks. Organizations install Intrusion Detection Systems (IDS) to alert suspicious traffic or activity. IDS generate a large number of alerts and most of them are false positive as the behavior construe for partial attack pattern or lack of environment knowledge. Monitoring and identifying risky alerts is a major concern to security administrator. The present work is to design an operational model for minimization of false positive alarms, including recurring alarms by security administrator. The architecture, design and performance of model in minimization of false positives in IDS are explored and the experimental results are presented with reference to lab environment.
Extending response-time analysis of Controller Area Network (CAN) with FIFO queues for mixed messages (2011)

Existing response-time analysis for Controller Area Network (CAN) messages in networks where some nodes implement FIFO queues while others implement priority queues, assumes that at every node, CAN messages are queued for transmission periodically or sporadically. However, there are a few high level protocols for CAN such as CANopen and Hägglunds Controller Area Network (HCAN) that support the transmission of mixed messages as well. A mixed message can be queued for transmission both periodically and sporadically. The existing analysis of CAN with FIFO queues does not support the analysis of mixed messages. We extend the existing response-time analysis of mixed-type CAN messages. The extended analysis can compute the response-times of mixed (periodic/ sporadic) messages in the CAN network where some nodes use FIFO queues while others use priority queues.
Evaluating web resources for disability access (2000)

A majority of Web based information, facilities and services is unnecessarily inaccessible to people with certain disabilities, largely due to a lack of awareness of accessibility issues on the part of developers. This paper argues that currently available accessibility evaluation methods are unsatisfactory in the scope and presentation of their results. Consequently, there is a need for a meta- method which utilises the strengths of current methods, but which also bridges their weaknesses. The paper discusses a comprehensive, yet usable methodology for evaluating web sites for accessibility. Using this methodology, a semi- automatic accessibility evaluation tool is proposed, which will guide evaluators through the auditing process and produce a set of tailored recommendations for making the subject site accessible.
Legal Education in Asia (2006)

Abstract This article starts off by providing an overview of the historical and structural aspects of legal education in selected representative jurisdictions in Asia. It then proceeds to tackle what the authors feel to be the most serious challenges faced by Asian law schools today - the need to balance legal education and inter-disciplinary perspectives, to provide sufficient comparative material, to reform teaching and assessment methodology, and to juggle competing needs with very limited resources.
On the definition of self-organizing systems (1964)

Published in: Proceedings of the IEEE ( Volume: 52, Issue: 3, March 1964)
Therapy for lowering lipoprotein (a) levels (1997)

Elevated levels of lipoprotein (a), a complex between apolipoprotein (a) and LDL, indicate an increased risk of atherosclerosis and cardiovascular disease. The important genetic regulation of lipoprotein (a) is now relatively well understood, but the progress in finding ways of influencing plasma lipoprotein (a) has been disappointingly slow. Nicotinic acid, pharmacological doses of sex hormones and anabolic steroids, as well as LDL apheresis may provide sufficient lowering of lipoprotein (a) for the evaluation of clinical response. Presently, the most important aspect is to take an evaluated lipoprotein (a) level into consideration when deciding to institute particularly aggressive lipid lowering treatment in a given individual.
Genetics and regulation of outer membrane protein expression by quinolone resistance loci nfxB, nfxC, and cfxB (1992)

Quinolone resistance mutations (cfxB1, marA1, and soxQ1) that reduce porin outer membrane protein OmpF map near 34 min on the Escherichia coli chromosome. Another such mutation, nfxC1, was found in strain KF131 (nfxB, 19 min). nfxC1 and cfxB1 mutants (selected with quinolones) differed slightly but reproducibly from marA1 (selected with tetracycline) and soxQ1 (selected with menadione) mutants in quinolone resistance and linkage to zdd2208::Tn10kan (33.7 min). For nfxB nfxC1 and cfxB1 mutants, as previously shown for marA mutants, resistance and reduced OmpF required the micF locus encoding an antisense RNA complementary to ompF mRNA and were associated with increased micF expression.
Accurate estimation of vector dependent leakage power in the presence of process variations (2009)

With the increasing importance of run-time leakage power dissipation (around 55% of total power), it has become necessary to accurately estimate it not only as a function of input vectors but also as a function of process parameters. Leakage power corresponding to the maximum vector presents itself as a higher bound for run-time leakage and is a measure of reliability. In this work, we address the problem of accurately estimating the probabilistic distribution of the maximum runtime leakage power in the presence of variations in process parameters such as threshold voltage, critical dimensions and doping concentration. Both sub-threshold and gate leakage current are considered. A heuristic approach is proposed to determine the vector that causes the maximum leakage power under the influence of random process variations. This vector is then used to estimate the lognormal distribution of the total leakage current of the circuit by summing up the lognormal leakage current distributions of the individual standard cells at their respective input levels. The proposed method has been effective in accurately estimating the leakage mean, standard deviation and probability density function (PDF) of ISCAS-85 benchmark circuits. The average errors of our method compared with near exhaustive random vector testing for mean and standard deviation are 1.32% and 1.41% respectively.