gebhart/patrepeval huggingface dataset:
Gadolinium-associated nephrogenic systemic fibrosis. (2009)

Nephrogenic systemic fibrosis is a progressive, potentially fatal multiorgan system fibrosing disease related to exposure of patients with renal failure to the gadolinium-based contrast agents used in magnetic resonance imaging. Because of this relationship between nephrogenic systemic fibrosis and gadolinium-based contrast agents, the U.S. Food and Drug Administration currently warns against using gadolinium-based contrast agents in patients with a glomerular filtration rate less than 30 mL per minute per 1.73 m2, or any acute renal insufficiency related to the hepatorenal syndrome or perioperative liver transplantation. There have been reports of nephrogenic systemic fibrosis developing in patients not exposed to gadolinium-based contrast agents, but most patients have the triad of gadolinium exposure through contrast-enhanced magnetic resonance imaging, renal failure, and a proinflammatory state, such as recent surgery, endovascular injury, or sepsis. Development of nephrogenic systemic fibrosis among patients with severe renal insufficiency following exposure to gadolinium-based contrast agents is approximately 4 percent, and mortality can approach 31 percent. The mechanism for nephrogenic systemic fibrosis is unclear, and current treatments are disappointing. Prevention with hemodialysis immediately following gadolinium-based contrast agents has been recommended, but no studies have shown this to be effective. Because of the large number of patients with clinically silent renal impairment and the serious consequences of nephrogenic systemic fibrosis related to gadolinium exposure, physicians should use alternative imaging modalities for patients who are at risk.
Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor (2010)

We examined the role that N-linked glycans play in the synthesis and expression of von Willebrand Factor (VWF). Blocking the addition of N-linked glycans (NLGs) or inhibiting initial glycan processing prevented secretion of VWF. To determine whether specific glycosylation sites were important, the 16 VWF N-linked glycosylation sites were mutated followed by expression in HEK293T cells. Four NLG mutants affected VWF expression: N99Q (D1 domain), N857Q (D' domain), N2400Q (B1 domain), and N2790Q (CK domain) either abolished or reduced secretion of VWF and this was confirmed by metabolic labeling. Multimer analysis of mutant N2790Q cell lysate revealed an increase in VWF monomers, which was also observed when the isolated CK domain was expressed with N2790 mutated. Immunofluorescence microscopy showed that mutants N99Q, N857Q, and N2790Q were primarily retained within the ER, producing only few pseudo Weibel-Palade bodies over longer time periods compared with wtVWF. All the variants also showed an increase in free thiol reactivity. This was greatest with N857Q and D4-C2 NLG mutants, which had approximately 6-fold and 3- to 4-fold more free thiol reactivity than wtVWF. These data provide further evidence of the critical role that individual N-linked glycans play in determining VWF synthesis and expression.
Learning and Modeling Unit Embeddings Using Deep Neural Networks for Unit-Selection-Based Mandarin Speech Synthesis (2020)

A method of learning and modeling unit embeddings using deep neutral networks (DNNs) is presented in this article for unit-selection-based Mandarin speech synthesis. Here, a unit embedding is defined as a fixed-length embedding vector for a phone-sized unit candidate in a corpus. Modeling phone-sized embedding vectors instead of frame-sized acoustic features can better measure the long-term dependencies among consecutive units in an utterance. First, a DNN with an embedding layer is built to learn the embedding vectors of all unit candidates in the corpus from scratch. In order to enable the extracted embedding vectors to carry both acoustic and linguistic information of unit candidates, a multitarget learning strategy is designed for the DNN. Its optional prediction targets include frame-level acoustic features, unit durations, monophone and tone identifiers, and context classes. Then, another two DNNs are constructed to map linguistic features toward the extracted embedding vectors. One of them employs the unit vectors of preceding phones besides the linguistic features of current phone as its input. At synthesis time, the distances between the unit vectors predicted by these two DNNs and the ones derived from unit candidates are used as a part of the target cost and a part of the concatenation cost, respectively. Our experiments on a Mandarin speech synthesis corpus demonstrate that learning and modeling unit embeddings improve the naturalness of hidden Markov model (HMM)-based unit selection speech synthesis. Furthermore, integrating multiple targets for learning unit embeddings achieves better performance than using only acoustic targets according to our subjective evaluation results.
Knelpunten door rijangst (2004)

Als je minder of moeilijker kunt autorijden omdat de angst toeslaat op alledaagse trajecten, kom je er al snel achter dat je voor een aantal problematische situaties wordt geplaatst. Waar je vorig jaar bij het verbouwen van de keuken nog zonder nadenken naar de doe-het-zelver in de naburige stad reed, wacht je nu braaf tot het weekend: dan heeft vast een van je kinderen wel even de tijd om te rijden. Het is hinderlijk en vernederend om te ervaren dat je afhankelijk wordt van anderen.
[Experimental study on cricoarytenoid joint movement]. (1991)

Through the study on 80 sides of the cricoarytenoid joints, it was proved that the cricoarytenoid joint was a small joint having multiple forms of movements. As the glottis opened or closed the arytenoid cartilage would slide first along the major axis of the joint facet, then round the inclined axle complemented by transverse and perpendicular movements round the joint facet. The closing movements of the glottis took place at the anterior part of the joints while the opening movements at the posterior part of the joints. The vocal process would move outwards and inwards as the arytenoid cartilage slided along the direction of the major axis of the joint facet.
Characterization of Cricket Paralysis Virus-Induced Polypeptides in <i>Drosophila</i> Cells (1980)

Cricket paralysis virus purified from Galleria mellonella larvae was shown to be similar to virus purified from Drosophila melanogaster cells. Cricket paralysis virus contained three major structural polypeptides of similar molecular weight (around 30,000), had a buoyant density of 1.344 g/ml, and had a capsid diameter of 27 nm. Twenty virus-induced polypeptides could be detected in CrPV-infected Drosophila cells. Two major polypeptides found in the infected cells corresponded to two structural viral polypeptides (VP1 and VP3), whereas the third major intracellular polypeptide was the apparent precursor of the third viral structural polypeptide (VP2). Three of the primary virus-induced polypeptides had molecular weights of 144,000, 124,000, and 115,000. These and other polypeptides were chased into lower-molecular-weight proteins when excess cold methionine was added after a short [(35)S]methionine pulse. Although cricket paralysis virus has a number of characteristics in common with the mammalian enteroviruses, the extremely fast processing of high-molecular-weight polypeptides into viral proteins seems atypical. Also, no VP4 (8,000 to 10,000 molecular weight) has been found in the virus particles.
A Fluorescence Sensor for Detection of Geranyl Pyrophosphate by the Chemo-Ensemble Method (2008)

Hexaamide receptor 4 and coumarin phosphate 5 form an ensemble for effective sensing of geranyl pyrophosphate (GPP). Fluorescence resonance energy transfer in the 4 + 5 ensemble diminishes when 5 is replaced by GPP. Receptor 4 binds selectively with GPP over other anions, including fatty acids. The 4-GPP complex in 1:1 stoichiometry is inferred by NMR and fluorescence titrations. Receptor 4 contains a pseudotetrahedral cleft to accommodate GPP via multiple hydrogen bonds, and the two aliphatic chains exert additional hydrophobic interactions.
PERFORMANCE EVALUATION OF TURBO CODED OFDM SYSTEMS AND APPLICATION OF TURBO DECODING FOR IMPULSIVE CHANNEL (2010)

ICTACT Journals are peer reviewed International Journals published quarterly. With the objective of creating Indian-based Journals of International quality and to build up local research content, ICTACT Journals exists for the purpose of providing a quality peer-reviewed platform for Scientists, Researchers, Academicians and Engineers who carry out their original research. The Journals will highlight the continued growth and new challenges in both basic research and application development.
Aliivibrio finisterrensis sp. nov., isolated from Manila clam, Ruditapes philippinarum and emended description of the genus Aliivibrio (2009)

Four strains isolated from cultured Manila clam, Ruditapes philippinarum, in the north-western coast of Spain were characterized phenotypically and genotypically. Phylogenetic analyses based on the 16S rRNA gene sequences indicated that these bacteria were closely related to Aliivibrio wodanis, Aliivibrio salmonicida, Aliivibrio fischeri and Aliivibrio logei with sequence similarities between 98.1 and 96.0 %. Phylogenetic analysis based on the RNA polymerase alpha chain (rpoA), RecA protein (recA), the alpha-subunit of bacterial ATP synthase (atpA) and the uridine monophosphate (UMP) kinase (pyrH) genes and fluorescent amplified fragment length polymorphism experiments clearly showed that these novel isolates form a tight genomic group different from any currently known Aliivibrio species. On the basis of phylogenetic analysis and phenotypic data, the four strains represent a novel taxon, for which the name Aliivibrio finisterrensis sp. nov. is proposed. Several phenotypic features were revealed that discriminate A. finisterrensis from other Aliivibrio species. The type strain is CMJ 11.1(T) (=CECT 7228(T)=LMG 23869(T)).
The Role of Palmitoylation in Functional Expression of Nicotinic α7 Receptors (2004)

Neuronal alpha-bungarotoxin receptors (BgtRs) are nicotinic receptors that require as yet unidentified post-translational modifications to achieve functional expression. In this study, we examined the role of protein palmitoylation in BgtR expression. BgtR alpha7 subunits are highly palmitoylated in neurons from brain and other cells capable of BgtR expression, such as pheochromocytoma 12 (PC12) cells. In PC12 cells, alpha7 subunits are palmitoylated with a stoichiometry of approximately one palmitate per subunit, and inhibition of palmitoylation blocks BgtR expression. In cells incapable of BgtR expression, such as human embryonic kidney cells, alpha7 subunits are not significantly palmitoylated. However, in these same cells, chimeric subunits with the N-terminal half of alpha7 fused to the C-terminal half of serotonin-3A receptor (alpha7/5-HT3A) subunits form functional BgtRs that are palmitoylated to an extent similar to that of BgtRalpha7 subunits in PC12 cells. Palmitoylation of PC12 and alpha7/5-HT3A BgtRs occurred during assembly in the endoplasmic reticulum (ER). In conclusion, our data indicate a function for protein palmitoylation in which palmitoylation of assembling alpha7 subunits in the ER has a role in the formation of functional BgtRs.
Introduction of LHRH-antagonists into the treatment of gynaecological disorders (1994)

Journal Article Introduction of LHRH-antagonists into the treatment of gynaecological disorders Get access Th. Reissmann, Th. Reissmann Search for other works by this author on: Oxford Academic PubMed Google Scholar K. Diedrich, K. Diedrich 3 1Clinic for Obstetrics and Gynaecology, University of LϋbeckGermany 3 To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar A.M. Comaru-Schally, A.M. Comaru-Schally 2Endocrine, Polypeptide and Cancer Institute, VA and Tulane University Medical CenterNew Orleans, LA, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar A.V. Schally A.V. Schally 2Endocrine, Polypeptide and Cancer Institute, VA and Tulane University Medical CenterNew Orleans, LA, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Reproduction, Volume 9, Issue 5, 1 May 1994, Pages 767–769, https://doi.org/10.1093/oxfordjournals.humrep.a138593 Published: 01 May 1994 Article history Received: 13 December 1993 Accepted: 24 February 1994 Published: 01 May 1994
Genetic and phenotypic microdiversity of Ochrobactrum spp (2006)

The diversity of Ochrobactrum anthropi, Ochrobactrum intermedium, Ochrobactrum tritici and Ochrobactrum grignonense in agricultural soil and on the wheat rhizoplane was investigated. O. anthropi was isolated both from soil and from the rhizoplane, O. intermedium and grignonense only from bulk soil, and O. tritici only from the wheat rhizoplane. On the genetic level, the immunotrapped isolates and a number of strains from culture collection mainly of clinical origin were compared with rep-PCR profiling using BOX primers, and a subset of these isolates and strains using REP primers. The isolates clustered according to their species affiliation. There was no correlation between rep clusters of O. anthropi isolates and habitat (place of isolation). The genetic diversity of Ochrobactrum at the species level as well as microdiversity of O. anthropi (number of BOX groups) was higher in soil than on the rhizoplane. Similarity values from genetic rep-PCR profiles correlated positively with DNA-DNA reassociation percentages. Isolates with >80.7% similarity in BOX profile and >86.4% in rep profile clustered within the same species. Similarity analysis of rep-PCR profiles is hence an alternative to DNA-DNA hybridization as a genomic criterion for species delineation within the genus Ochrobactrum. We used the substrate utilization system BIOLOG-GN to compare the immunotrapped isolates on the phenetic level. For the isolates from bulk soil, substrate utilization versatility (number of utilized substrates) and substrate utilization capacity (mean conversion rate of substrates) were slightly but significantly higher than for the isolates from the rhizoplane. This trend was also seen using API 20E and 20NE systems. Plate counts of total bacteria and the number of immunotrapped Ochrobactrum isolates per gram dry weight were higher for the rhizoplane than for the soil samples. The results of genetic and phenotypic analyses indicated a 'rhizosphere effect'; the diversity and metabolic capacity of Ochrobactrum isolates were higher in bulk soil, and the population density was higher on the wheat rhizoplane.
Trans-Sacral Steroid Injection for Low Back Pain and Lumbosacral Radiculopathy (1989)

Steroid and local anesthetics were injected into the epidural space through the posterior sacral foramen or lumbar approach in 4 patients for the purposes of relieving severe low back pain and radiculopathy. These patients were referred from other sections dealing with low back pain and radiculopathy, because one could not tolerate the surgical stress due to a heart problem, another two did not want the operation and the last had post-laminectomy status. All patients were satisfied with the results subjectively.
A Clinician's Guide to Oral Extended-Release Drug Delivery Systems in Epilepsy (2018)

Epilepsy is one of the most common chronic neurologic disorders that affects individuals of all ages. It is primarily managed with antiepileptic drugs (AEDs), with the goal of maintaining complete seizure control combined with minimal or no adverse effects. Oral administration is the mainstay of AED delivery for patients with chronic epilepsy and consists essentially of immediate-release (IR) and modified-release (delayed-release and extended-release [ER]) dosage formulations. Extended-release formulations (hydrophilic or hydrophobic matrix systems, reservoir systems, and osmotic-release systems) release a drug in a controlled manner during an extended period of time following administration. Extended-release formulations have many advantages compared with IR formulations, including simplification of dosing regimens, reduction in pill burden, and reduction in the peak-to-trough fluctuations in serum drug concentration that may be associated with a decreased risk of adverse effects and of seizures. These advantages have the potential to increase adherence to antiepileptic therapy, improve the quality of life of patients, and reduce health care costs. This article, which is intended as a practical guide for clinicians, reviews the properties of the different ER AED formulations currently available and discusses the advantages of ER over IR formulations. Subsequently, an explanation of the technologic basis of the different oral ER formulations, the critical attributes that differentiate ER products, and their individual strengths and weaknesses is provided. Specific recommendations to practitioners on treating patients with ER formulations are included.
Association rule hiding methods (2013)

Abstract Privacy preserving data mining has been recently introduced to cope with privacy issues related to the data subjects in the course of the mining of the data. It has also been recognized that it is not only the data that need to be protected but sensitive knowledge hidden in the data as well. Knowledge hiding is an emerging area of research focusing on appropriately modifying the data in such a way that sensitive knowledge escapes the mining and is not communicated to the public for privacy purposes. This article investigates the development of techniques falling under the knowledge‐hiding umbrella that pertain to the association rule‐mining task. These techniques are known as association rule hiding or frequent pattern hiding approaches, and have been receiving a lot of attention lately because they touch upon important issues of handling a sort of commonly used patterns such as the frequent patterns and the association rules. We present an overview of this area as well as a taxonomy and a presentation of an important sample of algorithms. © 2013 Wiley Periodicals, Inc. This article is categorized under: Algorithmic Development > Association Rules Technologies > Association Rules
M-FHMIP mechanism for mobile multicasting in IP networks (2008)

Fast handover is essential to support seamless multicast service in MIPv6. To reduce handover latency of multicast, there are two handover mechanisms, one is M-FMIP that prepares fast L3 handover before L2 handover and the other is M-HMIP that performs local area mobile multicast management. This paper proposes M-FHMIP that integrates an advantage of M-FMIP and M-HMIP, and analyzes the multicast handover latency.
Evaluation of Immunomagnetic Separation for Recovery of <i>Cryptosporidium parvum</i> and <i>Giardia duodenalis</i> from High-Iron Matrices (2000)

ABSTRACT In this study we examined the recovery of Cryptosporidium parvum and Giardia duodenalis from matrices containing various concentrations of dissolved iron. The organisms were recovered by using the immunomagnetic separation-immunofluorescent assay method, and the levels of recovery were compared to the dissolved iron concentrations. The levels of recovery of C. parvum decreased sharply at dissolved iron concentrations greater than 4 mg/liter, while the levels of recovery of G. duodenalis decreased sharply at concentrations greater than 40 mg/liter.
Design of Building Monitoring Systems Based on Wireless Sensor Networks (2010)

Wireless Sensor Network provides a potential technique for monitoring the indoor environment. This paper presents a Building Monitoring system based on Wireless Sensor Networks. A clustering-based network specified for building monitoring is proposed, which is inspired by LEACH (Low Energy Adaptive Cluster Hierarchy) method. Further, two key ideas are used to implement the clustering-based network. First, the configuration module of building management software is used to conduct all nodes in a room forming a local cluster. This cluster formation method does not consume node energy. Second, because cluster-heads cannot directly transmit packets to the sink node due to limited wireless communication range, the cluster-head communications are represented by a multi-hop tree rooted at the sink node. The experiment has been made to demonstrate the feasibility of the proposed results.
Dimension reduction based on centroids and least squares for efficient processing of text data (2001)

Dimension reduction in today's vector space based information retrieval system is essential for improving computational efficiency in handling massive data. In our previous work we proposed a mathematical framework for lower dimensional representations of text data in vector space based information retrieval, and a couple of dimension reduction method using minimization and matrix rank reduction formula. One of our proposed methods is CentroidQR method which utilizes orthogonal transformation on centroids, and the test results showed that its classification results were exactly the same as those of classification with full dimension when a certain classification algorithm is applied. In this paper we discuss in detail the CentroidQR, and prove mathematically its classification properties with two different similarity measures of L2 and cosine.
A study on the characterization of the incipient failure behavior of insulators in power distribution line (1999)

A feasibility study on the characterization of incipient insulator failure for distribution fault prediction is presented. In this study, real distribution data was collected and analyzed to isolate incipient failure signatures or parameters which were expected to show distinct behaviors before and after failure incident. Several signal analysis methods were applied to isolate the parameters and a new strategy of analysis, the event-date concept, was also applied to find a relationship between nonharmonic and high frequency signal activities and imminent insulator failures.
THE EFFECT OF GROWTH PHASE, CRYOPROTECTANTS AND FREEZING RATES ON THE SURVIVAL OF SELECTED MICRO-ORGANISMS DURING FREEZING AND THAWING (2001)

The effect of growth phase of cells, cryoprotectant agents and freezing rate on the survival of selected micro-organisms (Bacillus cereus, Lactobacillus plantarum, Escherichia coli, Pseudomonas fluorescens, Saccharomyces cerevisiae, Kluyveromyces lactis, Candida utilis, Mucor racemosus, Aspergillus niger) during freezing and thawing was studied.In cases where significant differences were observed stationary phase cells always survived better than exponential phase ones, while of the two cryoprotectant agents studied, horse serum + inositol was always superior to skimmed milk powder + inositol.The effect of freezing rate was different among the studied micro-organisms.
A Checkpoint/Restart Scheme for CUDA Applications with Complex Memory Hierarchy (2013)

Checkpoint/restart has been an effective mechanism to achieve fault tolerance for many scientific applications. However, as GPU becomes a much bigger role in high performance computing, there is no effective checkpoint/restart scheme yet due to GPU's batch-mode execution manner. The paper proposes an application-level checkpoint/restart scheme to save and restore GPU computation states. A precompiler and run-time support module are developed to construct and save states in CPU system memory dynamically. Secondary storage can be utilized for scalability and long-term fault tolerance. CUDA applications with complicated memory use are support as well. Experimental results have demonstrated the effectiveness of the proposed scheme.