gebhart/patrepeval huggingface dataset:
Implantable MICS-based wireless solution for bladder pressure monitoring (2017)

This paper covers the design, development and prototyping of an implantable wireless bladder pressure monitoring system. The proposed device is an essential part of a novel health solution intended for patients with bladder dysfunctions. It allows the urologist to closely monitor the intravesical pressure and the patient to evacuate the collected urine on time, thus increasing his quality of life. The proposed implant includes a minimal number of components. Communication is performed through FDA-approved on-device RF transceivers, and an external base station. The base station integrates a Microsemi's ZL70120 module while the communication implant employs a ZL70123. Pressure measurement is made with custom built biocompatible Piezo-resistive pressure sensor probes operated in differential mode. The implant achieves a power consumption of 2.1 mW in sleeping mode while the consumption in operating mode is 18.6 mW. The communication range is around 2.5 meters. System design and experimental results are reported and discussed.
Pneumatosis cystoides intestinalis and jejunoileal bypass. (1978)

This paper introduces the basic concepts and implementation of a Vibrating Intrinsic Reverberation Chamber (VIRC). This kind of chambers is used in electromagnetic compatibility testing, and offer some advantages compared to traditional chambers. An introduction, an overview of theoretical principles, a description of the VIRC recently built at the CAERCEM research center at Instituto Tecnolo´gico de Buenos Aires, and some measurements obtained during its initial characterization process are included.
Perfluorinated Plastic Optical Fiber Tapers for Evanescent Wave Sensing (2009)

In this work we describe the fabrication and the characterization of perfluorinated plastic-cladded optical fiber tapers. The heat-and-pull procedure has been used to fabricate symmetric tapers. Devices with different taper ratio have been produced and the repeatability of the process has been verified. The very low refractive indexes of the core-cladding perfluorinated polymers (n = 1.35-1.34) permit a strong enhancement of the evanescent wave power fraction in aqueous environments (n = 1.33), making them very attractive for evanescent wave sensing. The tapers have been characterized carrying out evanescent field absorbance measurements with different concentrations of methylene blue in water and fluorescence collection measurements in an aqueous solution containing Cy5 dye. A good sensitivity, tightly related to the low refractive index of the core-cladding materials and the geometrical profile, has been shown.
An overview of loco-regional treatments in patients and mouse models for hepatocellular carcinoma (2015)

Hepatocellular carcinoma is a highly aggressive malignancy and is the third leading cause of cancer-related deaths worldwide. Although surgery is currently considered the most effective curative treatment for this type of cancer, it is note that most of patients have a poor prognosis due to chemioresistence and tumor recurrence. Loco-regional therapies, including radiofrequency ablation, surgical resection and transcatheter arterial chemoembolization play a major role in the clinical management of hepatocellular carcinoma. In order to improve the treatment outcome of patients diagnosed with this disease, several in vivo studies by using different techniques on cancer mouse models have been performed. This review will focus on the latest papers on the efficacy of loco-regional therapy and combined treatments in patients and mouse models of hepatocellular carcinoma.
Distribution of aromatase P450 transcripts and adipose fibroblasts in the human breast. (1996)

The fibroblast component of adipose tissue is the primary extraglandular site of aromatase P450 (P450arom) expression, which is responsible for the conversion of C19 steroids to estrogens. Previously, we have shown positive correlations between the level of P450arom transcripts and the ratio of fibroblasts to mature adipocytes in adipose tissue samples proximal to breast tumors. The present study was conducted to determine the distribution of P450arom messenger ribonucleic acid (RNA) levels and fibroblast to adipocyte ratios in disease-free breasts of premenopausal women. Adipose tissue samples were collected from 3 regions (outer, upper, and inner) of both breasts of 13 women undergoing reduction mammoplasty. The histological composition of adipose tissue (n = 12) was determined by morphometry using a computerized image analysis program. We used a competitive RT-PCR method employing rat P450arom complementary RNA as an internal standard to quantify adipose P450arom transcripts in tissue total RNA samples (n = 11). Overall, 67% of the highest fibroblast to adipocyte ratios and 64% of the highest P450arom transcript levels were detected in an outer breast region, whereas in only 1 patient were the highest values detected in an inner region. Parametric ANOVA showed significant differences between the fibroblast content of the regions [p(F) = 0.037]. This distribution pattern directly correlates with the most common or the least common sites of carcinoma in the breast, the outer and inner regions, respectively. Moreover, a direct relationship was demonstrated between adipose fibroblasts and P450arom transcripts within the breast, in that regions with the highest fibroblast to adipocyte ratios contained the highest P450arom transcript levels (by ANOVA of contrast variables, P = 0.0009). These results suggest that, similar to our previous findings in the breast bearing a tumor, adipose tissue aromatase expression in the disease-free breast is determined by the local ratio of fibroblasts to adipocytes.
Criticism of Generally Accepted Fundamentals and Methodologies of Traffic and Transportation Theory (2013)

It is shown that fundamentals of traffic and transportation theory like LighthillWhitham- Richards (LWR) theory, the General Motors model class, principles for traffic and transportation network optimization and control (e.g., Wardrop’s user equilibrium (UE) and system optimum (SO) principles) are not consistent with the set of the fundamental empirical features of traffic breakdown at a highway bottleneck. Alternatively to these generally accepted fundamental of traffic and transportation theory, we discuss three-phase traffic theory as the basis for traffic flow modeling as well as briefly consider the network breakdown minimization (BM) principle for the optimization of traffic and transportation networks with road bottlenecks.
Full complex spectrum simultaneous obtaining SD-OCT (2010)

An efficient technique of simultaneous obtaining of quadrature spectral components of interference signal in spectrometer-based OCT is proposed. The components are obtained in air-spaced non-polarization interferometer by partition of reference beam onto two parts and using an achromatic phase shifter. Several setups of phase sifter are described and compared.
Logic performance of 40 nm InAs/In<inf>x</inf>Ga<inf>1&#x2212;x</inf>As composite channel HEMTs (2010)

Current Si-CMOS technology has come to a limit that novel semiconductors as alternative channel materials (Ge, InSb, In <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1−x</inf> As) are urgently needed for high-speed and low-power logic devices for post CMOS era [1]. Recent research shows III–V heterostructure field-effect transistors demonstrate aggressive merits due to its high electron mobility and rather mature process technology [2]. The outstanding low field electron transport characteristics of III–V materials make ultrahigh-speed switching at very low supply voltage possible [3]. Here, we present the latest advancement of 40 nm InAs/In <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1−x</inf> As composite channel High Electron Mobility Transistor (HEMT) devices that have achieved excellent digital logic characteristics at very low power level.
Biodistribution and displacement studies of the selective 5-HT2Areceptor antagonist 123I-5-I-R91150 in the normal dog (2002)

There is increasing interest in mapping receptors in vivo by using functional imaging modalities such as single photon emission tomography (SPET) and positron emission tomography (PET). Since SPET is a more accessible functional imaging modality than PET and, overall, it is more economical, radioligands suitable for this technique are in greater demand. Recently, 123I-5-I-R91150, a radioligand with high selectivity and affinity for 5-HT(2A) receptors in the brain, was introduced for SPET. This study reports on the whole-body distribution and brain uptake of the selective 123I-5-I-R91150 ligand in four normal dogs. The frontal to cerebellar ratio of uptake in time was determined in three dogs. Time-activity curve of venous blood was determined in one dog. Maximal global brain uptake was found at 10-60 min post-injection. Higher brain uptake was noted in the frontal cortical areas compared to the cerebellum. The frontal-cerebellar ratio reached the highest values at 90-180 min. Reversibility and pharmacological selectivity of ligand binding was demonstrated through displacement and blocking studies with the 5-HT(2A) receptor antagonist ketanserin. This study demonstrates that the specific 5-HT(2A) iodinated ligand can be used for imaging and semi-quantification of the 5-HT(2A) receptors in the canine brain in vivo by using SPET.
Total Ankle Replacement Through a Lateral Approach (2015)

Since the first clinical series of total ankle replacements in 1973, implants design has evolved tremendously. Early catastrophic failures associated with first-generation total ankle replacement are now less common with modern prostheses. However, registry data suggest that the 10-year survivorship is still lower than total knee and hip arthroplasty. The anterior surgical approach used in the vast majority of implants lies between 2 angiosomes and can lead to complications including wound breakdown and damage to the peroneal nerves and anterior tibial artery. Furthermore, current anterior approach implants do not allow bony resections to parallel the sagitally curved talar and tibial surfaces; cuts are limited to flat/chamfered cuts which inherently take more bone than curved, matched, bony resections. In 2012, the FDA approved the Zimmer Trabecular Metal Total Ankle Replacement, which is a placed through the lateral approach. This approach theoretically minimizes surgical intrusion on a previously traumatized anterior soft-tissue envelope and allows direct visualization of the curved talus and tibial surfaces. In addition, such an approach allows bone-sparing, curved resections that maximize bony contact and theoretically minimize component subsidence. Furthermore, this implant is based on using a rigid alignment stand to which the lower extremity and milling guides are fixed, allowing for both the correction of deformity and the accurate resection of bone. The aim of this paper is to present the design rationale and useful technical tips for surgeons implanting this prosthesis. Level of Evidence: Diagnostic Level 4. See Instructions for Authors for a complete description of levels of evidence.
The Challenge to the Rule of Homology Modeling: Folding Mechanism Study of Protein GA and GB with High Sequence Identity but Different Native Structures (2013)

As one of the most valuable methods for drug design, homology modeling shows that protein structures are more conserved than protein sequences, that is, the proteins with high sequence identity have high structural similarity, but protein pairs G(A)88/G(B)88 and G(A)95/G(B)95 prove the opposite. The pairs G(A)88 and G(B)88 shares the 88% sequence identity, but display different structures, and the pair G(A)95 and G(B)95 with 95% sequence identity yet presents different structures. The research on these proteins provides an opportunity of complementary study. In the process of protein folding, at which stage the protein final structure was determined and which residues were important for folding to a given structure were still unknown. Here we used OPLS all-atom force field for molecular dynamics simulations to study the unfolding of G(A)88, G(B)88, G(A)95 and G(B)95 at high temperatures, and used the process of protein unfolding to reverse the process of protein folding. G(B)88 and G(B)95 folded to the α+β structure, but G(A)88 and G(A)95 folded to the all-α-helix structure. In the process of G(A)88 and G(A)95 folding, the helices folded earlier than the formation of tertiary interactions. In the process of folding to G(B)88 and G(B)95, the α-helix formed earlier. We showed that early along the folding pathway, the final protein structure was confirmed, and very small differences between protein sequences determined the protein structure.
Temperature-Dependent Models of European Corn Borer (Lepidoptera: Pyralidae) Development in North Carolina1 (1982)

Journal Article Temperature-Dependent Models of European Corn Borer (Lepidoptera: Pyralidae) Development in North Carolina Get access T. E. Anderson, T. E. Anderson 2 Department of Entomology, North Carolina State University, Raleigh, North Carolina 27650 2 Present Address: Boyce Thompson Institute for Plant Research at Cornell University, Tower Road, Ithaca, NY 14853. Search for other works by this author on: Oxford Academic PubMed Google Scholar G. G. Kennedy, G. G. Kennedy Department of Entomology, North Carolina State University, Raleigh, North Carolina 27650 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. E. Stinner R. E. Stinner Department of Entomology, North Carolina State University, Raleigh, North Carolina 27650 Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 11, Issue 6, 1 December 1982, Pages 1145–1150, https://doi.org/10.1093/ee/11.6.1145 Published: 01 December 1982 Article history Received: 13 November 1981 Published: 01 December 1982
Transcatheter perforation of the right ventricular outflow tract as initial therapy for pulmonary valve atresia and intact ventricular septum in the newborn (1997)

The clinical impact of transcatheter perforation and dilatation of the right ventricular outflow tract in neonates with pulmonary atresia and intact ventricular septum was reviewed. Between April 1992 and December 1994, 8 neonates underwent transcatheter perforation of the right ventricular outflow tract. Radiofrequency energy was employed in 6 patients and wire perforation in 2 patients. Mean patient age at intervention was 1.9 ± 0.6 days and weight 3.4 ± 0.5 kg. Median tricuspid valve annulus was 10.9 mm (range: 4.0–13.0 mm) and Z-value −0.85 (range: −4.5–1.0). The mean right ventricular systolic pressure fell from 117 ± 16 to 55 ± 15 mm Hg (P < 0.0001), and the right ventricular to aortic pressure ratio decreased from 1.81 ± 0.33 to 0.82 ± 0.28 (P < 0.0001). The arterial duct was patent in all. No acute complications occurred. Aortopulmonary shunts were performed in 7 patients at a median 6 days (range: 3–23 days) following catheterization. One patient developed sepsis and died after surgical resection of infected tissue, while a second patient died of a blocked aortopulmonary shunt 17 months following discharge. Median follow-up for the 6 surviving patients was 8 months (range: 4–32 months). One patient has achieved and a second is awaiting biventricular repair. Transcatheter perforation appears to be a promising form of therapy in selected patients with pulmonary atresia, and potentially facilitates algorithms leading to a biventricular repair. Cathet. Cardiovasc. Diagn. 40:408–413, 1997. © 1997 Wiley-Liss, Inc.
A specific receptor of biological cystine polyion: distance-selective extraction and efficient chirality sensing with an ytterbium porphyrinate tweezerElectronic supplementary information (ESI) available: synthesis of ytterbium porphyrinate tweezer 1a and zinc analog 4. See http://www.rsc.org/suppdata/cc/b2/b206708k/ (2002)

An ytterbium porphyrinate dimer acts as a new class of tweezer-type receptor, which offers selective extraction of biological cystine polyion and chirality sensing with circular dichroism spectroscopy.
XPS and XRD study of photoconductive CdS films obtained by a chemical bath deposition process (1996)

Cadmium sulfide layers have been obtained from CdCl2, CS(NH2)2, NH4Cl, NH3 and H2O solutions using the chemical bath deposition technique at 50 °C. After dipping in a solution of 0.7 mass% CdCl2 in CH3OH and thermal treatment under Ar at 400 °C for 30 min, the CdS layers obtained acquire a photosensitivity amounting to a ratio, between photocurrent values in the light and in the dark, of four orders of magnitude. The chemical changes of the layers occurring, as evidenced by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS), during their preparation in solution and after thermal treatment are discussed.
A TECHNIQUE FOR ORTHOTOPIC LIVER TRANSPLANTATION IN THE RAT (1973)

This report describes in detail the technique of orthotopic liver transplantation in syngeneic rats which are relatively inexpensive and readily available. We also report the long-term survival and function of these grafts. The technique involves the use of a miniaturized extracorporeal portal to jugular shunt. The donor liver is perfused and cooled. Implantation is accomplished using standard microvascular suture techniques. Successful orthotopic liver transplants were performed in 47 of 64 rats. Long-term survival up to 14 months was achieved in seven animals. Liver function was measured by serial determination of bilirubin, serum glutamic oxaloacetic transaminase (SGOT), and alkaline phosphatase. Elevations in bilirubin and SGOT in the immediate postoperative period returned to normal by the second postoperative week. Marked variations were seen in alkaline phosphatase values, and there was slow return to normal levels. Open liver biopsies were performed on long-term survivors at 3, 5, and 7 months and revealed essentially normal liver parenchyma, with slight mononuclear infiltration of the portal spaces and some sinusoidal dilatation. The practicability of the transplant and organ preservation, and the advantages of using the inbred rat as the experimental animal are discussed.
Effects of Secretion Removal on Bovine Mammary Gland Function Following an Extended Milk Stasis (1999)

The objective of this study was to determine whether lactation function could be reinitiated after a period of extended milk stasis. Involution was induced by milk stasis in lactating Holstein cows for a period of 11 d. On d 11, one side of the mammary gland was milked twice daily for 3 d. The contralateral side remained unmilked for the 14-d experimental period. Cows were slaughtered, and mammary tissue was collected from both udder halves for further analysis. Mammary secretion volume was partially restored in the milked udder half, but reestablished milk yields were variable among cows. A partial recovery of lactation function was further indicated by elevated levels of lactose and protein profiles resembling milk in mammary secretions from the milked glands. Lactose and protein profiles from the unmilked glands were similar to those of glands undergoing involution. Lactoferrin levels were elevated in secretions from the milked and unmilked udder halves. Casein and lactoferrin synthesis by mammary explants and beta-casein and lactoferrin mRNA abundance in mammary tissues corresponded to protein profiles from milked and unmilked mammary secretions. alpha-Lactalbumin mRNA was variable but was more abundant in the milked glands compared with the unmilked glands. Lectin fluorescence microscopy for soybean agglutinin preferentially stained the apical surface of the mammary epithelial cells from the milked glands. Staining was absent in the unmilked glands and suggested resumption of lactation function in all such milked glands. These results suggest that mammary involution can be partially reversible after 11 d of milk stasis.
Protein and Energy Requirements of Term and Preterm Infants (1983)

Little new evidence has been presented to warrant altering protein and energy requirements of term infants. Breast milk remains the benchmark. Feeding preterm infants, however, presents multiple challenges only now beginning to be faced. In the past, respiratory distress and infections were such emergencies that little attention was given to nutritional needs. While optimal rates of growth are not even now known, nor even measurements to tell what is "optimum", at least the requirements for certain growth rates which are not accompanied by undue stress can be met by pre-term fresh breast milk and specially designed formulas.
[Treatment of acute myeloid leukemia in the elderly with low-dose cytosine arabinoside]. (1994)

We report the outcome of 95 patients older than 60 years with de novo acute non-lymphocytic leukaemia (ANLL), treated in two institutions during a 10 year period. Thirty-two patients, mean age 78 years, did not receive any chemotherapy, and their median survival was 38 days. Five patients in good clinical condition, aged 60-63 years, were treated conventionally with an anthracycline and cytarabine, and three patients obtained a complete remission (CR) lasting 73, 417, and 1050 days. Fifty-eight patients were treated with low-dose cytarabine (LDC) for remission-induction and maintenance. Eighteen patients obtained CR, yielding a remission rate of 31%. The median duration of remission was 380 days and median survival of the same group was 498 days. LDC is valuable in the treatment of ANLL in the elderly. Controlled studies are warranted to define the indications for LDC versus conventional therapy in the large grey zone of elderly patients.
TCP Wave estimation of the optimal operating point using ACK trains (2018)

TCP Wave changes the typical TCP transmission paradigm by replacing the ACK-clocked sliding window with self-scheduled bursts. In response to bursts, unmodified TCP receivers generate ACK trains, which carry useful information about the end-to-end link characteristics. TCP Wave inspects ACK-train flow to measure the following parameters: (i) ACK train spread (namely ACK train dispersion) and (ii) RTT variations. The former is expected to provide the overall “service capacity”, meant as the maximum capacity allowed over the end-to-end path, while the latter is considered as a congestion indicator. The joint use of such measurements allows TCP Wave to fine-tune the transmission rate to accurately match current network resource availability in the bottleneck link. This paper analysis TCP Wave ACK train-based measurements on a broad set of simulated links compliant to characteristics of today's real networks. To this scope, a testbed with TCP Wave implementation on Linux OS is used to perform tests varying both bottleneck capacity and physical latency.