gebhart/patrepeval huggingface dataset:
Complexation of enalapril maleate with beta-cyclodextrin: NMR spectroscopic study in solution (2006)

A detailed NMR ( 1 H , COSY, ROESY) spectroscopic study of complexation of enalapril maleate with -cyclodextrin was carried out. The 1 H NMR spectrum of enalapril maleate confirmed the existence of cis-trans equilibrium in solution, possibly due to hindered rotation along the amide bond. The cis-trans ratio remained almost the same in the presence of -cyclodextrin but in one case it was found significantly different which suggests a catalytic role of -cyclodextrin in the isomerization. 1 H NMR titration studies confirmed the formation of an enalapril--cyclodextrin inclusion complex as evidenced by chemical shift variations in the proton resonances of both the host and the guest. The stoichiometry of the complex was determined to be 2:1 (guest: host). The mode of penetration of the guest into the -cyclodextrin cavity as well as the structure of the complex were established using ROESY spectroscopy.
Interactive shadow analysis for camera heading in outdoor images (2014)

Image geo-localization is an important problem with many applications such as augmented reality and navigation. The most common ways to geo-localize an image are to use its meta-data such as GPS or to match it against a geotagged database. When neither of those is available, it is still possible to apply shadow analysis to determine the camera heading for outdoor images. This could be useful pruning the search space in geo-localization applications, for example by removing roads with incompatible orientations from a database such as Open Street Map. In this paper, we develop a novel interactive method for deducing the global heading of a query image using the shadows in it. We start by constructing a model of the sun-earth system to determine all shadows possible at a given approximate latitude, and compare shadows within the query to those possible under the model to determine the range of possible headings. We demonstrate this on 54 query images with known ground truth, and show that in 52 cases the ground truth lies in the computed range.
[Dawn of the clinical cure for chronic hepatitis B]. (2020)

The discovery of hepatitis B virus (HBV) has provided a scientific basis for the diagnosis, prevention and treatment of chronic hepatitis B (CHB). The universalization of neonatal hepatitis B vaccine has greatly reduced the HBsAg positive load rate of the Chinese population. Antiviral therapy based on interferon and / or nucleos(t)ide analogues had effectively inhibited HBV replication, improved liver inflammation, liver fibrosis, and reduced the incidence of liver cirrhosis and hepatocellular carcinoma. However, the existing treatment methods can achieve the clinical cure goal of negative HBsAg. In recent years, direct antiviral drugs for HBV life cycle and immunomodulatory drugs for antiviral response have entered an active stage of research and development. Clinical trials that are well-designed, standardized, analyzed, and interpreted are the key to the success of the research and development of a clinical cure for hepatitis B. It is hoped that the experts in hepatology, clinical pharmacology and methodology will work together to promote the research and development process of new drugs for clinical cure of hepatitis B by adopting new clinical trial design, new endpoint indicators, new data management and quality control technology.
Intellectual Disability In Rural Black Children In The Bushbuckridge District Of South Africa (1997)

Abstract The aim of this project was to investigate the prevalence and aetiology of intellectual disability in rural black children in the Bushbuckridge district. Children (aged 2–9 years) were screened by local trained field-workers who interviewed the caregivers with a simple questionnaire. Children who screened positive were examined by a paediatrician. Altogether 4581 children were screened, 541 had a paediatric assessment, and 152 (3,3%) were found to have an intellectual disability (IQ ≤ 80). The mild to severe disability ratio was 4:1, and 52% of affected children with an IQ ≤ 70 had associated disorders. The aetiology of the disability was congenital in 25% of cases, acquired in 11% and undetermined in 64%. The affected male to female ratio was 3:2. These findings have implications for the provision of appropriate special education, as well as health preventive services.
Cumulative effects of early lactation diseases on fertility and survival in a multi-state population of Holstein cows (2018)

Endocrine changes at calving and drastic metabolic adjustments to support milk synthesis result in negative energy balance and immune suppression. Consequently, a substantial proportion of cows are affected by disease around the time of calving, and most health disorders occur in the first 30 DIM. Diseases have been associated with reduced reproductive performance and increased risk of death and culling. However, large multi-state prospective studies analyzing the effect of health events by use of standardized disease definitions and times of assessment are scarce. Therefore, our objective was to test the cumulative effect of combinations of health events on fertility and survival of a large population of Holstein cows in multiple states.
Math readiness: the implications for engineering majors (2004)

Good Math skills are essential to obtain academic success in engineering majors in college. Timing of when these skills are developed, while not a requirement for success is highly correlated with success in engineering programs. At Texas Tech University, Calculus III is a required course for all programs in the College of Engineering except for degrees in the engineering technology department. Success of a "C" or better grade in Calculus III is usually associated with a future engineering graduate. An analysis was made to determine the probability of completing a "C" or better grade in Calculus III as a function of starting position in math as an incoming freshman. Texas Tech University has a well established math placement process that regulates the starting position based on math skills. The results of over 4,000 engineering students are presented.
mApoE-Functionalized Nanoliposomes Delivering Doxorubicin and Ultrasmall Superparamagnetic Iron Oxide to Glioblastoma Cells Characterized by TEM and Confocal Microscopy (2015)

Journal Article mApoE-Functionalized Nanoliposomes Delivering Doxorubicin and Ultrasmall Superparamagnetic Iron Oxide to Glioblastoma Cells Characterized by TEM and Confocal Microscopy Get access Simona Rodighiero, Simona Rodighiero Molecular and Cellular Imaging Platform, Fondazione Filarete, Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar Maria Gregori, Maria Gregori Department of Health Sciences, University of Milano-Bicocca, Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar Maura Francolini, Maura Francolini Molecular and Cellular Imaging Platform, Fondazione Filarete, Milan, ItalyDepartment of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar Elena Vezzoli, Elena Vezzoli Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar Matteo Tamborini, Matteo Tamborini Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, ItalyFondazione Vollaro, Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar Massimo Masserini, Massimo Masserini Department of Health Sciences, University of Milano-Bicocca, Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar Michela Matteoli, Michela Matteoli Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, ItalyPharmacology and Brain Pathology Lab, Humanitas Clinical and Research Center, Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar Lorena Passoni Lorena Passoni Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 21, Issue S3, 1 August 2015, Pages 559–560, https://doi.org/10.1017/S1431927615003591 Published: 23 September 2015
3‐Amino Pyrazoles as Potent and Selective Glycogen Kinase Synthase 3 (GSK‐3) Inhibitors (2006)

This chapter contains sections titled: Identification of 5-Aryl Pyrazolopyridines Identification of 5-Aryl Pyrazolopyridazines Structure-Based Design of 6-[Het]Aryl Pyrazolopyridines Cytochrome P450 and In vitro Microsomal Clearance Data for 5-Aryl Pyrazolopyrid[az]ines and 6-[Het]Aryl Pyrazolopyridines In vivo Efficacy Data for a Selective, Orally Bioavailable GSK-3 Inhibitor Emerging Templates Containing a 3-Amino Pyrazole Scaffold References
Enhancement of Mouse Thymus Cells Response to Periodate Treatment by a Soluble Factor (1972)

Abstract Mouse lymph node and spleen lymphocytes are stimulated by sodium periodate (NaIO4) treatment, whereas mouse thymus cells show a minimal response. Hydrocortisone-resistant thymus cells are much more responsive to phytohemagglutinin than NaIO4 treatment. Thymus cells are rendered highly responsive to NaIO4 treatment upon addition of cell-free supernatants of mouse spleen cell and macrophage cultures. Treatment of mouse spleen cells and macrophages with NaIO4 stimulates the production of the enhancing factor for thymus cell response.
AN ULTRASENSITIVE VIBRATING PROBE FOR MEASURING STEADY EXTRACELLULAR CURRENTS (1974)

We describe a vibrating probe system for measuring relatively steady electrical current densities near individual living cells. It has a signal-to-noise ratio at least 100 times greater than previously available techniques. Thus it can be used to detect current densities as small as 10 nA/cm(2) in serum when a 30-microm diameter probe is vibrated at 200 Hz between two points 30 microm apart, and the amplifier's time constant is set at 10 s. Moreover, it should be generally insensitive to interference by concentration gradients. It has been first used to reveal and study 100-s long current pulses which developing fucoid embryos drive through themselves.
Temperature-Dependent de Haas-Van Alphen Parameters in Zinc (1954)

The magnetic susceptibility of a single crystal of zinc has been investigated from 4.2\ifmmode^\circ\else\textdegree\fi{}K to 300\ifmmode^\circ\else\textdegree\fi{}K in fields up to 25 kilogauss. Traces of the de Haas-van Alphen effect persisted at temperatures as high as 200\ifmmode^\circ\else\textdegree\fi{}K. The period of the characteristic susceptibility oscillations increased with increasing temperature, rising from 6.4\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}5}$ ${\mathrm{gauss}}^{\ensuremath{-}1}$ at 4.2\ifmmode^\circ\else\textdegree\fi{}K to 12.5\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}5}$ ${\mathrm{gauss}}^{\ensuremath{-}1}$ at 61.2\ifmmode^\circ\else\textdegree\fi{}K. If present interpretations of the de Haas-van Alphen parameters are valid, temperature dependent effective masses, or chemical potential, or both are implied for the pertinent electrons. A rough calculation indicates that temperature dependences of the right order of magnitude might arise from alteration of the overlap of Brillouin zone boundaries by the Fermi surface as a result of anisotropic thermal expansion of the lattice.In addition to the main oscillations, terms exhibiting periods of approximately 2\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}7}$ ${\mathrm{gauss}}^{\ensuremath{-}1}$ were observed at 4.2\ifmmode^\circ\else\textdegree\fi{}K but were not investigated in detail.
Outcome of Radiation Therapy for Locally Advanced Vulvar Carcinoma: Analysis of Inguinal Lymph Node (2019)

ILN diameters ≤30 mm and prescribed doses over 60 Gy were associated with ILN control in patients with vulvar carcinoma.
Fertigation Effect of Distillery Effluent on Agronomical Practices of <i>Trigonella foenum-graecum</i> L. (Fenugreek) (1970)

The present study was conducted to asses the fertigation effect of distillery effluent as agro-based biofertigant. Different fertigant doses of Distillery effluent (DE) such as 5, 10, 25, 50, 75 and 100% were used for fertigation of Trigonella foenum-graecum along with control bore well water (BWW). The study revealed that the fertigant, rich in plant nutrients, affected the agronomical characteristics of T. foenum-graecum (Pusa early bunching) and physico-chemical characteristics of the soil as well. On irrigation of soil with different effluents up to 90 days of harvesting, there was a significant effect on moisture content (P<0.01), EC, pH, Cl-, TOC, HCO3-, CO3-2, Na+, K+, Ca2+, Mg2+, Fe2+, TKN, NO32-, PO43- and SO42- (P<0.001) and insignificant effect on WHC and bulk density (P>0.05). There was no significant change in the soil texture. Among various concentrations of DE, irrigation with 100% DE decreased pH (16.66%) and increased moisture content (30.82%), EC (84.13%), Cl- (292.37%), TOC (4311.61%), HCO3- (27.76%), CO3-2 (32.63%), Na+ (273%), K+ (31.59%), Ca2+ (729.76%), Mg2+ (740.47%), Fe2+ (301.90%), TKN (1723.32%), NO32- (98.02%), PO43- (337.79%) and SO42- (77.78%). The agronomical parameters such as shoot length, root length, number of roots, root nodule, number of leaves, flowers, pods, pod length, dry weight, chlorophyll content, leaf area index (LAI), crop yield and harvest index (HI) of T. foenum-graecum were recorded to be in increasing order at low concentrations of DE i.e., 5 to 50% and in decreasing order at high concentrations of DE i.e., 75 to 100% as compared to control. Stimulation was observed in seed emergence period and shoot length, root length, number of leaves and biomass with the increase in effluent concentration in early seedling growth period.DOI: 10.3126/on.v8i1.4312
A first-in-human phase I study of the anti-PD-1 antibody PDR001 in patients with advanced solid tumors. (2016)

3060 Background: PDR001 is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1. PDR001 binds to PD-1 with high affinity and inhibits the biological activity of PD-1. Methods: Phase I dose escalation study of PDR001 given i.v. Q2W or Q4W to adult patients with advanced solid tumors. A Bayesian linear model estimating the dose–exposure relationship and a Bayesian logistic regression model with overdose control were used to guide dose escalation. Preliminary population PK analysis was conducted to estimate PK parameters and assess the impact of weight as a covariate on clearance and volume of distribution. Results: In the dose escalation part of the study, 58 patients have been treated with PDR001 at 5 dose levels and schedules: 1 mg/kg Q2W (16 pts); 3 mg/kg Q2W (15), 10 mg/kg Q2W (11), 3 mg/kg Q4W (6) and 5 mg/kg Q4W (10). 27/58 patients have been treated for > 3 cycles (cycle length: 28 days), and 27/58 remain on treatment at the time of abstract preparation. No dose limiting toxicity was reported. The most common AEs included: nausea, fatigue, anemia, diarrhea, dyspnea, vomiting, abdominal pain and headache. Three cases of hypothyroidism suspected to be related to PDR001 were reported. A single case of grade 3 autoimmune colitis was the only serious AE suspected to be related to PDR001. Approximately dose-proportional increases in exposure were observed from 1–10 mg/kg. PDR001 achieves an AUC0-336h of approximately 1000 µg*day/mL at cycle 3 with 3 mg/kg Q2W or 5 mg/kg Q4W. Based on the population PK analysis, a flat dose of 400 mg Q4W is predicted to achieve mean steady-state Ctrough concentrations of approximately 31 µg/mL (90% CI: 22–42 µg/mL), which exceeds the ex vivo EC50 for PD-1 blockade. The recommended phase 2 dose (RP2D) for PDR001 is therefore 400 mg Q4W. An alternative dosing regimen of 300 mg Q3W is expected to achieve similar exposure to 400 mg Q4W. Conclusions: Based on the preliminary data, PDR001 was well tolerated with a safety profile similar to those of other marketed anti-PD-1 antibodies. Based on the available PK and safety data described above, the RP2D of PDR001 has been declared as 400 mg i.v. Q4W, or 300 mg i.v. Q3W as an option for more convenient scheduling in combination treatment regimens. Clinical trial information: NCT02404441.
COURSE IN THE THEORY AND DESIGN OF PAETICLE ACCELERATORS - LECTURE IX (1953)

The synchrotron acOelerates electrons at a constant radius, with a constant oscillator frequency, and in an increasing magnetic field.Approximate configuration of the field is shown in Figure I.
ChemInform Abstract: Length of the Ethane Bond in Hexaphenylethane and Its Derivatives. (1987)

Abstract Crystals of the hexaphenylethane (IIa), grown by allowing cyclohexane solutions of the monomer (Ia) to stand for 2 months at room temp., belong to the space group Pm3n with Z=2.
Influence of method of processing supplemental alfalfa on intake and utilization of dormant, bluestem-range forage by beef steers (1993)

A digestion trial was conducted to determine the effect of method of processing supplemental alfalfa on the intake and utilization of dormant, bluestem-range forage. Supplement treatments were 1) control: no supplement; 2) ground and pelleted, suncured alfalfa; 3) ground and pelleted dehydrated alfalfa; and 4) longstem alfalfa hay. Bluestem forage intake (% BW), diet digestibility, and ruminal dry matter fill 4 hours after feeding were increased (P<.10) when supplemental alfalfa was fed, compared with no supplementation. Little difference was evident among different forms of supplemental alfalfa for most of the forage utilization characteristics measured. However, a weak trend (P=.18) was observed for increased intake of bluestem forage by the steers supplemented with dehydrated alfalfa pellets compared with suncured alfalfa pellets.
Ultra-low Energy, High Performance and Programmable Magnetic Threshold Logic (2013)

We propose magnetic threshold-logic (MTL) design based on non-volatile spin-torque switches. A threshold logic gate (TLG) performs summation of multiple inputs multiplied by a fixed set of weights and compares the sum with a threshold. MTL employs resistive states of magnetic tunnel junctions as programmable input weights, while, a low-voltage domain-wall shift based spin-torque switch is used for thresholding operation. The resulting MTL gate acts as a low-power, configurable logic unit and can be used to build fully pipelined, high-performance programmable computing blocks. Multiple stages in such a MTL design can be connected using energy-efficient ultralow swing programmable interconnect networks based on resistive switches. Owing to memory-based compact logic and interconnect design and low-voltage, high-speed spintorque based threshold operation, MTL can achieve more than two orders of magnitude improvement in energy-delay product as compared to look-up table based CMOS FPGA.
CAL-101, a Potent Selective Inhibitor of the p110δ Isoform of Phosphatidylinositol 3-kinase, Attenuates Pathway Signaling, Induces Apoptosis, and Overcomes Signals From the Microenvironment In Cellular Models of Hodgkin Lymphoma (2010)

Abstract Abstract 3926 Phosphatidylinositide 3-kinases (PI3Ks) are a family of lipid kinases that are involved in signaling events which control a diverse number of cellular processes. The class I kinases contain 4 isoforms designated p110α, β, δ, γ, and are activated by cell surface receptors. Aberrant regulation of the PI3K signaling pathway is frequently observed in human malignancies including those of hematological origin. CAL-101 is an oral p110δ-specific inhibitor which has shown preclinical and clinical activity in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). This compound is a potent p110δ inhibitor (EC50 of 65 nM in a whole-blood assay) with >200-fold selectivity over the other class I PI3K isoforms and no activity against Class II and III PI3K family members or other PI3K-related proteins, including mTOR and DNA-PK. Prior in vitro NHL studies revealed that CAL-101 induces caspase-dependent apoptosis, and inhibits CD40L-, BAFF-, CXCL12- and CXCL13-derived survival signals in cellular models (Lannutti BJ, et al., Blood 2010). To investigate the potential role of p110δ in Hodgkin lymphoma (HL) we screened a number of HL cell lines for p110δ isoform expression and constitutive PI3K pathway activation. We report high levels of p110δ protein and activated Akt in 5 of 5 HL cell lines evaluated (L428, L540, L591, L1236, KM-H2). Inhibition of p110δ with CAL-101 treatment of cell lines resulted in a reduction of Akt phosphorylation and a decrease in cellular viability. Because previous studies have established the importance of signals from the microenvironment for the survival and proliferation of malignant cells as well as for their resistance to standard therapies, we investigated the effect of p110δ inhibition by CAL-101 in HL cell line-stroma cocultures. In this setting, CAL-101 overcame tumor cell growth induced by coculture of HL cells with bone marrow stromal cells. In addition, CAL-101 induced dose-dependent apoptosis of HL cells at 48 hours. Furthermore, stromal cell coculture resulted in increased CCL5, CCL17, and CCL22 levels; productions of these chemokines by HL cells cultured in the presence of stromal cells were reduced by CAL-101 in a dose-dependent manner. These results indicate that specific inhibition of p110δ may disrupt signals between HL cells and their microenvironment, thereby providing the preclinical rationale for clinical evaluation of CAL-101 as a novel therapeutic approach in patients with Hodgkin lymphoma. Disclosures: Meadows: Calistoga Pharmaceuticals: Employment. Kashishian:Calistoga Pharmaceuticals: Employment. Johnson:Calistoga Pharmaceuticals: Employment. Lannutti:Calistoga Pharmaceutical Inc.: Employment.
Modélisation 3D du chauffage par induction des matériaux composites (2014)

Les materiaux composites sont de plus en plus utilises dans l’industrie. Au cours des differentes phases de transformation de ces materiaux, un apport de chaleur est souvent necessaire. Si le renfort est conducteur electrique, le chauffage par induction peut etre avantageux par rapport a d’autres modes de chauffage. Ce travail presente une approche de modelisation 3D du chauffage par induction des materiaux composites qui sont de nature multi-echelles, heterogenes et anisotropes. Dans les modeles, ces materiaux sont remplaces par des materiaux homogenes equivalents a l’aide de methodes d’homogeneisation predictives ou experimentales. Dans ce cadre, nous avons propose une methode experimentale basee sur la mesure de l’impedance pour determiner la conductivite electrique. D’autre part, ces materiaux se presentent sous forme de plaque d’epaisseur tres faible comparee aux autres dimensions. Deux modeles ont etes mis en place, un modele elements coques anisotropes monocouche et un modele multicouche dedies aux composites stratifies a structures orientees. Une confrontation entre les resultats de simulations et les mesures experimentales a permis de valider les modeles developpes.
Advances in Neem and Azadirachtin Chemistry and Bioactivity (1993)

Utilization of azadirachtin is rapidly becoming an accepted method for the disruption of insect molting, and thus is an effective insect growth regulator for most insects during the larval and pupal stages of development. Azadirachtin and related compounds are derived from the mevalonic acid pathway in the neem tree (Azadirachta indica) and other members of the Meliaceae family. Azadirachtin is a complex tetranortriterpenoid with 16 chiral carbon centers, too complex to synthesize commercially. Aflatoxins B1 and B2 are usually present in neem extracts so caution must be used to hygienically control the level to insure safe use. Growth regulator mechanisms may involve interactions between azadirachtin and ecdysone, with either synergistic, replacement, or antagonistic mechanisms possible. We have compared structural and biochemical properties of the two.