gebhart/patrepeval huggingface dataset:
THE PURIFICATION OF THYROXINE-BINDING PROTEIN BY IONEXCHANGE RESINS1 (1957)

Journal Article THE PURIFICATION OF THYROXINE-BINDING PROTEIN BY IONEXCHANGE RESINS Get access S. H. INGBAR, S. H. INGBAR 1Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services Boston City Hospital; Department of Medicine Harvard Medical School Boston Massachusetts; Howard Hughes Medical Institute Search for other works by this author on: Oxford Academic Google Scholar J. T. DOWLING, J. T. DOWLING 1Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services Boston City Hospital; Department of Medicine Harvard Medical School Boston Massachusetts; Howard Hughes Medical Institute Search for other works by this author on: Oxford Academic Google Scholar N. FREINKEL N. FREINKEL 1Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services Boston City Hospital; Department of Medicine Harvard Medical School Boston Massachusetts; Howard Hughes Medical Institute Search for other works by this author on: Oxford Academic Google Scholar Endocrinology, Volume 61, Issue 3, 1 September 1957, Pages 321–326, https://doi.org/10.1210/endo-61-3-321 Published: 01 September 1957 Article history Received: 30 April 1957 Published: 01 September 1957
ISO 17025 REQUIREMENTS: HOW TO EVALUATE UNCERTAINTY FOR DIOXIN ANALYSIS IN FOOD AND FEED FROM VALIDATION DATA? (2002)

peer reviewed
Echoes of the past: Evolution, development, health and disease. (2004)

Extract: Well over 90% of our existence as a species was prior to the development of agriculture, which has brought forth many cultural changes. Thus understanding our biology and our capacity to respond to the environment may be enhanced by reference to our own evolutionary history. Moreover, knowledge from our recent past (i.e., the study of life history), particularly the environmental conditions experienced by our parents and grandparents and from our own early life, provide additional insights. These elements come together - our combined ecological, evolutionary, and societal histories -- in understanding the concept known as "developmental origins of adult disease," first described over a decade ago. One genotype (a specific genetic make up) can generate a range of phenotypes (features or characteristics). Much of this diversity is determined by developmental plasticity, processes by which environmental influences induce irreversible changes in the developmental path of the organism. Developmental plasticity must be distinguished from developmental disruption in which an environmental challenge is teratogenic (causes defects in the fetus) and disruptive to the normal pattern of development.
Titanium Mesh for the Repair of Skull Base Bone Defects (2007)

Purpose: The objective of this study was to evaluate the surgical principle and complications of titanium mesh used for the reconstruction of skull base bone defect. Titanium is a nonferrous metal used for reconstruction of cranial defects following tumor resection, trauma, or infection.
Hydrogenation of Succinic Anhydride by Nickel-Molybdenum Catalyst Supported on SiO2-Al2O3-Composition and Activity of Catalyst- (1974)

無水コハク酸を接触水素化してγ-ブチロラクトンおよびテトラヒドロフラソを得るのに有効な触媒として,ニッケルにモリブデンを添加した触媒系を見いだした。モリブデンの対ニッケル原子比を0～0.3の範囲で変化させて触媒活性を検討したところ,0～0.14の範囲ではモリブデンの添加量を増すにしたがって活性は向上したが,0.14以上では逆に低下した。触媒担体としてケイソウ土とSiO2,Al203とを用いて比較したところ活性,選択性いずれに対してもSiO2,Al203が良好であった。各種組成の触媒についてX線回折を行ない,モリブデンがニッケルに固溶していることがわかった。さらにNi(III)面の格子定数と結晶粒径とを求めて,触媒活性との関係を求めた。
Pastures: Towards Usable Security Policy Engineering (2007)

Whether a particular computing installation meets its security goals depends on whether the administrators can create a policy that expresses these goals - security in practice requires effective policy engineering. We have found that the reigning SELinux model fares poorly in this regard, partly because typical isolation goals are not directly stated but instead are properties derivable from the type definitions by complicated analysis tools. Instead, we are experimenting with a security-policy approach based on copy-on-write "pastures", in which the sharing of resources between pastures is the fundamental security policy primitive. We argue that it has a number of properties that are better from the usability point of view. We implemented this approach as a patch for the 2.6 Linux kernel
Transforming Colloidal Cs4PbBr6 Nanocrystals by Poly(maleic anhydride-alt-1-octadecene) into Stable CsPbBr3 Perovskite Emitters Through Intermediate Heterostructures (2020)

The preparation of strongly emissive CsPbBr3 perovskite nanocrystals with a robust surface passivation is a challenge in the field of lead halide perovskite nanomaterials. We report an approach to prepare polymer-capped CsPbBr3 perovskite nanocrystals by reacting oleylammonium/oleate-capped Cs4PbBr6 nanocrystals with poly(maleic anhydride-alt-1-octadecene) (PMAO). PMAO contains succinic anhydride units that are reactive towards the oleylamine species present on Cs4PbBr6 nanocrystals’ surface and produces polysuccinamic acid, which, in turn, triggers the Cs4PbBr6 to CsPbBr3 conversion. The transformation occurs through the formation of Cs4PbBr6-CsPbBr3 heterostructures as intermediates, which were captured because of the mild reactivity of PMAO and were investigated by high-resolution electron microscopy. The Cs4PbBr6-CsPbBr3 heterostructures demonstrate a dual emission at cryogenic temperature with an indication of the energy transfer from Cs4PbBr6 to CsPbBr3. The fully-transformed CsPbBr3 NCs have high photoluminescence quantum yield and enhanced colloidal stability, which we attribute to the adhesion of polysuccinamic acid to the NC surface through its multiple functional groups in place of oleate and alkylammonium ligands. The PMAO-induced transformation of Cs4PbBr6 NCs opens up a strategy for the chemical modification of metal halide NCs initially passivated with nucleophilic amines.
Development of Integrated Chassis Control Algorithms to Improve Vehicle Dynamics (2006)

Most electronic chassis control systems so far have been designed for optimization of its own performance. This, sometimes, has resulted in performance degradation when two or more control modules were operating together. Recently. great R&D effort is being given to judicious integration of individual chassis control systems in an effort to further enhance the overall vehicle performance. In this paper, two integrated control logics - one that integrates the brake and suspension control systems and the other that integrates the brake and steering control systems - have been developed. The main control target of both logics is vehicle dynamics control under critical situations. The two logics were tested under various driving conditions in a reliable simulation environment and their synergetic effects were investigated. The results indicate that the proposed logics can yield better vehicle performance than the cases when the individual chassis control modules work without any integration scheme.
Elevated ²-Human Chorionic Gonadotropin and Testosterone in Cord Serum of Male Infants of Diabetic Mothers* (1985)

Leydig cell hyperplasia is a common histological finding in male infants of diabetic mothers. The functional correlates of this histological finding were investigated by measuring beta hCG, testosterone, androstenedione, dihydrotestosterone, and progesterone in mixed cord serum of male and female infants of diabetic mothers (n = 40) and normal mothers (n = 40) at term. Male and female infants of diabetic mothers had significantly higher cord serum beta hCG levels than male and female controls. Male infants of diabetic mothers had significantly higher cord serum testosterone concentrations than male controls, female controls, and female infants of diabetic mothers. Cord serum testosterone concentrations were similar in female infants of diabetic mothers and female controls. In the male infants of diabetic mothers, there was a significant positive correlation between beta hCG and testosterone (r = 0.64; P less than 0.01). There was no significant correlation between beta hCG and testosterone in the male controls (r = -0.15; P = NS). There was no significant difference in cord serum dihydrotestosterone in any group tested. Cord serum progesterone was significantly higher in the males than in the females. Cord serum androstenedione was lower in the infants of diabetic mothers than in the controls. This study suggests that the Leydig cell hyperplasia found in male infants of diabetic mothers is due, in part, to elevated concentrations of hCG and is accompanied by elevated testosterone concentrations in the fetal compartment.
Corrigenda (1977)

A. E. Underhill, D. M. Watkins, D. J. Wood, S. David, M. Lépine, G. Aranda, G. Vass, P. Pertici, G. Simonelli, G. Vitulli, G. Deganello, P. L. Sandrini, A. Mantovani, R. Knorr, A. Weiss, A. F. Thomas and M. Ozainne, J. Chem. Soc., Chem. Commun., 1977, 392 DOI: 10.1039/C39770000392
Evaluation of therapeutic response to gemcitabine in pancreatic cancer. (2009)

Contrast-enhanced harmonic imaging is useful for evaluating treatment response for pancreatic cancer.
Chronic inflammatory demyelinating polyradiculoneuropathy (1992)

We reviewed our data from patients with the clinical diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Seventy patients had no demonstrable underlying disease to account for their polyneuropathy and were classified as idiopathic CIDP (CIDP-I). We detected a monoclonal gammopathy of uncertain significance (MGUS) in 30 patients who were classified as CIDP-MGUS; 17 had an IgG gammopathy, 12 an IgM gammopathy, and one an IgA gammopathy. Compared with CIDP-I patients, CIDP-MGUS patients were older and slightly more likely to be males. When compared with patients with an MGUS but without polyneuropathy reported in the literature, CIDP-MGUS patients had similar distributions of age, sex, and immunoglobulin class. There were no significant differences in motor and sensory nerve conduction measures between CIDP-I and CIDP-MGUS patients, nor between CIDP-MGUS patients with IgM and those with IgG or IgA gammopathy. Strict electrodiagnostic criteria for primary demyelination were fulfilled by 54% of CIDP-I patients and 40% of CIDP-MGUS patients, but these were not significantly different. Our study suggests that (1) the demographic features and immunoglobulin class distribution of CIDP-MGUS patients largely reflect those of patients with an MGUS, but without polyneuropathy, (2) CIDP-MGUS patients as a group cannot be distinguished from CIDP-I patients on the basis of nerve conduction studies, and (3) IgM CIDP-MGUS patients cannot be distinguished from those with other immunoglobulin classes.
Process-based Software Tweaking with Mobile Agents (2001)

We describe an approach based upon software process technology to on-the-fly monitoring, redeployment, reconfiguration, and in general adaptation of distributed software applications, in short 'software tweaking'. We choose the term tweaking to refer to modifications in structure and behavior that can be made to individual components, as well as sets thereof, or the overall target system configuration, such as adding, removing or substituting components, while the system is running and without bringing it down. The goal of software tweaking is manifold: supporting run-time software composition, enforcing adherence to requirements, ensuring uptime and quality of service of mission-critical systems, recovering from and preventing faults, seamless system upgrading, etc. Our approach involves dispatching and coordinating software agents - named Worklets - via a process engine, since successful tweaking of a complex distributed software system often requires the concerted action of multiple agents on multiple components. The software tweaking process must incorporate and decide upon knowledge about the specifications and architecture of the target software, as well as Worklets capabilities. Software tweaking is correlated to a variety of other software processes - such as configuration management, deployment, validation and evolution - and allows to address at run time a number of related concerns that are normally dealt with only at development time.
Phosphorus burns: a practical approach to local treatment. (1989)

Most phosphorus burns are of limited extent. First aid consists of vigorous irrigation with water or saline followed by application of soaked dressings. At the Rambam Medical Center Burn Unit, washing of the wounds with 1% copper sulfate and 5% sodium bicarbonate solutions occurs before removal of phosphorus particles. In selected patients, prompt excision of the injured tissue and skin grafting are recommended. Fluid replacement and close monitoring of ECG, serum calcium, phosphorus, and electrolytes are recommended for all patients with such burns.
Three-state quantum cryptography (2000)

Abstract We introduce a protocol for quantum key distribution using three mutually non-orthogonal states. The protocol generates key bits most efficiently for three symmetric states. The generalized measurements which minimize the error probability and maximize the mutual information for such a system are known and can be implemented optically. We analyse eavesdropping strategies based on these optimal measurements.
DESIGN OF A ROBOTIC WELDING SYSTEM FOR CLOSURE OF WASTE STORAGE CANISTERS (2005)

This work reported here was done to provide a conceptual design for a robotic welding and inspection system for the Yucca Mountain Repository waste package closure system. The welding and inspection system is intended to make the various closure welds that seal and/or structurally join the lids to the waste package vessels. The welding and inspection system will also perform surface and volumetric inspections of the various closure welds and has the means to repair closure welds, if required. The system is designed to perform these various activities remotely, without the necessity of having personnel in the closure cell.
Partition Theorems for Spaces of Variable Words (1994)

Furstenberg and Katznelson applied methods of topological dynamics to Ramsey theory, obtaining a density version of the Hales–Jewett partition theorem. Inspired by their methods, but using spaces of ultrafilters instead of their metric spaces, we prove a generalization of a theorem of Carlson about variable words. We extend this result to partitions of finite or infinite sequences of variable words, and we apply these extensions to strengthen a partition theorem of Furstenberg and Katznelson about combinatorial subspaces of the set of words.
Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters (1986)

The expression of p60v-src in chicken cells infected with Rous sarcoma virus causes stimulation of cell proliferation, morphological alteration, and anchorage independence. PA101 and PA104 are temperature-sensitive variants encoding mutant p60v-src proteins that are partially defective in the induction of these transformation parameters. To define the structural basis for the transformation defectiveness of the p60v-src mutants, the v-src genes of PA101 and PA104 were molecularly cloned and analyzed. Amino- and carboxy-terminal coding regions of the cloned mutant genes were exchanged with the corresponding regions of cloned wild-type v-src and chicken c-src genes, reconstructed into viral DNA, and expressed in infected cells maintained at various temperatures. This analysis revealed that lesions within the tyrosine kinase domains of the two mutant proteins confer temperature sensitivity on all three transformation functions of p60v-src. An amino-terminal region of the PA101 mutant protein, which coincides with the proposed modulatory domain and appears to interact with the kinase domain, affects morphological alteration in a temperature-independent manner. Our results suggest that the function of the kinase domain is essential to all three parameters examined, whereas the amino-terminal domain is important in determining cell morphology.
Local organ dose conversion coefficients for angiographic examinations of coronary arteries (2007)

New organ dose conversion coefficients for coronary angiographic interventions are presented, as well as dose distributions and resulting maximal local dose conversion coefficients in the relevant organs. For the Monte Carlo based simulations, voxel models of the human anatomy were employed which represent the average Caucasian adult man and woman as defined by the International Commission on Radiological Protection. In the 21 investigated projections, the mean organ dose conversion coefficients vary from a few 0.01 to 2 mGy(Gy cm(2))(-1), depending on the projections. However, especially in portions of the lungs and the active bone marrow, the conversion coefficients can locally amount up to 10 mGy(Gy cm(2))(-1), which is half the average conversion coefficient of the skin at the field entrance. In addition to the dose conversion coefficients, the dependence of the patient dose on the projection has been estimated. It could be shown that the patient doses are highest for left anterior oblique views with strong caudal or cranial orientation. Nevertheless, for a large range of image-intensifier positions no significant dose differences could be found.
Adipose tissue in obesity and obstructive sleep apnoea (2011)

A European Respiratory Society research seminar on "Metabolic alterations in obstructive sleep apnoea (OSA)" was jointly organised in October 2009 together with two EU COST actions (Cardiovascular risk in the obstructive sleep apnoea syndrome, action B26, and Adipose tissue and the metabolic syndrome, action BM0602) in order to discuss the interactions between obesity and OSA. Such interactions can be particularly significant in the pathogenesis of metabolic abnormalities and in increased cardiovascular risk in OSA patients. However, studying the respective role of OSA and obesity is difficult in patients, making it necessary to refer to animal models or in vitro systems. Since most OSA patients are obese, their management requires a multidisciplinary approach. This review summarises some aspects of the pathophysiology and treatment of obesity, and the possible effects of sleep loss on metabolism. OSA-associated metabolic dysfunction (insulin resistance, liver dysfunction and atherogenic dyslipidaemia) is discussed from the perspective of both obesity and OSA in adults and children. Finally, the effects of treatment for obesity or OSA, or both, on cardio-metabolic variables are summarised. Further interdisciplinary research is needed in order to develop new comprehensive treatment approaches aimed at reducing sleep disordered breathing, obesity and cardiovascular risk.
Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-alpha-lapachone by Curvularia lunata (1979)

Microbial transformation of lapachol, a naturally occurring naphthoquinone, was carried out by Curvularia lunata (NRRL 2178). The fungus brings about oxidative cyclization of the substrate to dehydro-alpha-lapachone, which was isolated and characterized by nuclear magnetic resonance and mass spectral analyses; its structure was verified by chemical synthesis. The metabolite is a naturally occurring chromene possessing antibacterial and antitumor activities.
Growth by MOMBE of c-axis superconducting YBCO thin films on different substrates: in situ RHEED monitoring of the growth (2003)

Superconducting YBCO c-axis oriented thin films have been grown by MOMBE (metalorganic molecular-beam-epitaxy). Growth of the films on different substrates [100] (Y,Nd)AlO/sub 3/, [100] SrTiO/sub 3/ and [100] MgO has been investigated by in situ monitoring the reflection high energy electron diffraction (RHEED). The paper discusses our results suggesting significant differences in films growth on the three presented substrates. The highest quality (high uniformity, epitaxy and low roughness) has been attained for the films prepared on SrTiO/sub 3/. All films, regardless substrates, have shown values between 81 and 84 K for zero resistance critical temperature T/sub c0/.
Using Mobile Phones to Facilitate Alcohol Dependent Patients to Improve Family Communication (2018)

This paper describes a pilot study involving alcohol-dependent patients and their family members aimed at identifying salient themes to guide the design of a mobile support system. We then developed a phone-based support system that facilitates communication between patients and their family members. The patient self-administers breath alcohol tests using a portable breathalyzer and self-reports moods and alcohol cravings. This information can then be shared with select family members who subsequently provide responses, such as encouragement or suggestions. The patients do not directly reply to the encouragement or suggestions, but rather use the same app to indirectly rate family's responses according to their effectiveness in assisting them to remain sober. These indirect ratings as well as other data provided by patients and family members can be used during following group interventions to assist counselors (the treatment team) in making suggestions about future intra-family communications, with the aim of breaking many of the negative loops that would otherwise impede positive interactions and the effectiveness of treatment.
Physiotherapy movement based classification approaches to low back pain: comparison of subgroups through review and developer/expert survey (2012)

Schemes vary on: the extent to which loading strategies are pursued; the assessment of movement dysfunction; and advocated treatment approaches. A biomechanical assessment predominates in the majority of schemes (MDT, PBC, MSI), certain psychosocial aspects (fear-avoidance) are considered in the TBC scheme, certain neurophysiologic (central versus peripherally mediated pain states) and psychosocial (cognitive and behavioural) aspects are considered in the OCS scheme.
ChemInform Abstract: CHEMICAL REACTIVITY AND MOLECULAR STRUCTURE RELATIONSHIP OF HIGHLY STRAINED CAGE OXETANES (1983)

Abstract Die Strukturen der Oxetane (12) sowie Reaktionen, 2.B. zu (II) und (III).
Use of Tamoxifen Before and During Pregnancy (2011)

For premenopausal patients with receptor-positive early breast cancer, administration of tamoxifen for 5 years constitutes the main adjuvant endocrine therapy. During pregnancy, tamoxifen and its metabolites interact with rapidly growing and developing embryonic or fetal tissues. Information about tamoxifen and pregnancy was gathered by searching PubMed. In addition, we had access to the records of the pharmaceutical company AstraZeneca. Because these observations are retrospective and other therapies and diagnostic measures are possible confounders, a causal relationship was not established between tamoxifen treatment and pregnancy outcome. The records from AstraZeneca documented three live births with congenital anomalies and four live births without congenital anomalies related to tamoxifen treatment before pregnancy. Tamoxifen therapy during pregnancy resulted in 16 live births with congenital malformations and a total of 122 live births without malformations. The 122 live births without malformations included 85 patients from a prevention trial that did not record a single anomaly, whereas the AstraZeneca Safety Database alone reported 11 babies with congenital malformations of 44 live births. Additionally, there were: 12 spontaneous abortions, 17 terminations of pregnancy without known fetal defects, six terminations of pregnancy with fetal defects, one stillbirth without fetal defects, two stillbirths with fetal defects, and 57 unknown outcomes. The relatively high frequency of severe congenital abnormalities indicates that reliable birth control during tamoxifen treatment is mandatory. After tamoxifen use, a washout period of 2 months is advisable based on the known half-life of tamoxifen. In case of an inadvertent pregnancy, risks and options should be discussed.