gebhart/patrepeval huggingface dataset:
Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells (1991)

Purified natural (n) and recombinant (r) murine (mu) mast cell growth factor (MGF, a c-kit ligand) were evaluated alone and in combination with r human (hu) erythropoietin (Epo), rhu granulocyte-macrophage colony-stimulating factor (rhuGM-CSF), rhuG-CSF, and/or rhuM-CSF for effects in vitro on colony formation by multipotential (colony-forming unit-granulocyte, erythroid, monocyte, megakaryocyte [CFU-GEMM]), erythroid (burst-forming unit erythroid [BFU-E]) and granulocyte-macrophage (CFU-GM) progenitor cells from normal human bone marrow. MGF was a potent enhancing cytokine for Epo-dependent CFU-GEMM and BFU-E colony formation, stimulating more colonies and of a larger size than either rhu interleukin-3 (rhuIL-3) or rhuGM-CSF. MGF, especially at lower concentrations, also acted with rhuIL-3 or rhuGM-CSF to enhance Epo-dependent CFU-GEMM and BFU-E colony formation. MGF had little stimulating activity for CFU-GM colonies by itself, but in combination with suboptimal to optimal amounts of rhuGM-CSF enhanced the numbers and the size of CFU-GM colonies in an additive to greater than additive manner. While we did not detect an effect of MGF on CFU-G colony numbers stimulated by maximal concentrations of rhuG-CSF, MGF did enhance the size of CFU-G-derived colonies. MGF did not enhance the activity of rhuM-CSF. In a comparative assay, maximal concentrations of rmu and rhuMGF were equally effective in the enhancement of human bone marrow colony formation, but rhuMGF, in contrast to rmuMGF, did not at the concentrations tested enhance colony formation by mouse bone marrow cells. MGF effects on BFU-E, CFU-GM, and CFU-GEMM may be direct acting ones as MGF-enhanced colony formation by these cells in highly enriched progenitor cell populations of CD34 HLA-DR+ and CD34 HLA-DR+CD33- sorted cells in which greater than or equal to 1 of 2 cells was a BFU-E plus CFU-GM plus CFU-GEMM. MGF appears to be an early acting cytokine that preferentially stimulates the growth of immature hematopoietic progenitor cells.
Task-specific evaluation of kinematic designs for instruments in minimally invasive robotic surgery (2013)

In minimally invasive robotic surgery, slender instruments are used that provide additional degrees of freedom inside the human body. Kinematic limitations due to the instrument could endanger the secure execution of a surgical task. Numerous design alternatives are proposed in literature whereas few work is done that evaluates the performance of these instruments objectively. This paper presents a new method to evaluate alternative designs of instrument kinematics with respect to their ability to perform surgical tasks. Two specific criteria are set up accounting for the limited space during a minimally invasive intervention as well as for the ability to execute the desired task. The evaluation is based on task specific reference trajectories which are recorded in one orientation. During robotic surgery, arbitrary orientations of this area can occur. The method is able to handle this by rotating the acquired reference trajectories within software. The presented method is independent from the setup, i.e. the relative position and orientation of the area of interest with respect to the trocar location. Four different examples demonstrate the application of the method to show its usefulness.
An Algebra for Logic Strength Simulation (1983)

To simulate tri-state logic in a non-pessimistic way, a six valued algebra is shown to be necessary. This is then extended to quin-state logic (strong 0, strong 1, weak 0, weak 1, high impedance) and a fifteen valued algebra. The improved accuracy is as important for fault simulation as for design verification. The requirements for non-pessimistic test generation algebras for tri-state and quin-state logic are also discussed. Pessimism in test generation increases the search space and hence the run time.
[BSE and scrapie diagnosis in Germany]. (2002)

The detection of pathological prion protein is considered as pathognomonic for the diagnosis of transmissible spongiform encephalopathies. According to the EU regulations cattle older than 30 months of age (Germany 24 months) and slaughtered for human consumption must be tested by using BSE rapid tests. Likewise must be fallen stock and clinically affected animals. This article gives an overview over the diagnostic hierarchy and organization of the diagnostic system for BSE and scrapie in Germany. All suspect cases found by rapid testing are reinvestigated and clarified by the National reference laboratory for these diseases which is part of the recently founded Institute of Novel and Emerging Infectious Diseases at the Federal Research Centre for Virus Diseases of Animals located on the isle of Riems. Until the end of 2001 130 BSE cases were confirmed out of 230 submissions.
The Fox Movietone News Preservation Project: The Progressive Scan CCD Camera (1996)

This paper describes a high-speed charge-coupled device (CCD) camera that has been developed for commercial, industrial, and scientific applications. It uses a 1024-line progressive scan imager with two video output channels. The dual-channel outputs provide a total data rate of 40 million pixels/sec, using “square pixel” sampling. The camera incorporates electronic shuttering triggered by an external source, so that the exposure period and frame rate can be precisely controlled. The camera features high linearity, low noise, wide dynamic range, and low shading. An early prototype of this camera was used by Fox News, Inc., to digitize film news-reels for the Fox Movietone project.
Session Description Protocol (SDP) Attributes for Open Mobile Alliance (OMA) Broadcast (BCAST) Service and Content Protection (2008)

This memo provides information for the Internet community.
Pathology Quiz Case 2 (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Otolaryngology–Head & Neck Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Otolaryngology–Head & Neck Surgery journal
SCL is coexpressed with GATA-1 in hemopoietic cells but is also expressed in developing brain. (1992)

The SCL gene encodes a putative transcription factor with a basic helix-loop-helix (B-HLH) motif and is known to be predominantly expressed in erythroid cells. Here we also demonstrate expression of SCL mRNA in normal mast cells, mast cell lines and megakaryocytic cell lines. SCL is therefore expressed in the same three lineages as GATA-1, a well-recognized hemopoietic transcription factor. SCL and GATA-1 mRNA were also co-expressed in interleukin 3-dependent primitive myeloid lines. In murine erythroleukemia (MEL) cells SCL and GATA-1 underwent coordinated biphasic modulation during hexamethylene bisacetamide (HMBA)-induced erythroid differentiation. The kinetics of SCL and GATA-1 mRNA expression was inversely correlated with changes in ID, a negative regulator of B-HLH proteins, and was distinct from changes in MYC, MYB and erythropoietin receptor transcripts. During myeloid differentiation of K562 cells, SCL and GATA-1 mRNA levels also underwent biphasic modulation. Thus SCL and GATA-1 are coordinately expressed in multiple hemopoietic lineages and coordinately regulated during induced erythroid and myeloid differentiation. In nonhemopoietic tissues SCL was only detected in adult and developing brain where GATA-1 is reportedly not expressed. In day 14.5 embryos analysed by in situ hybridization, SCL transcripts were detected in post-mitotic neurons in the metencephalon and roof of the mesencephalon. This suggests a previously unexpected role for SCL in neural differentiation.
Motion Aftereffect of Combined First-Order and Second-Order Motion (1999)

When, after prolonged viewing of a moving stimulus, a stationary (test) pattern is presented to an observer, this results in an illusory movement in the direction opposite to the adapting motion. Typically, this motion aftereffect (MAE) does not occur after adaptation to a second-order motion stimulus (i.e. an equiluminous stimulus where the movement is defined by a contrast or texture border, not by a luminance border). However, a MAE of second-order motion is perceived when, instead of a static test pattern, a dynamic test pattern is used. Here, we investigate whether a second-order motion stimulus does affect the MAE on a static test pattern (sMAE), when second-order motion is presented in combination with first-order motion during adaptation. The results show that this is indeed the case. Although the second-order motion stimulus is too weak to produce a convincing sMAE on its own, its influence on the sMAE is of equal strength to that of the first-order motion component, when they are adapted to simultaneously. The results suggest that the perceptual appearance of the sMAE originates from the site where first-order and second-order motion are integrated.
Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3-<i>b</i>]pyridazin-8-amine Derivatives as Tankyrase Inhibitors (2014)

Searching for selective tankyrases (TNKSs) inhibitors, a new small series of 6,8-disubstituted triazolo[4,3-b]piridazines has been synthesized and characterized biologically. Structure-based optimization of the starting hit compound NNL (3) prompted us to the discovery of 4-(2-(6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-ylamino)ethyl)phenol (12), a low nanomolar selective TNKSs inhibitor working as NAD isostere as ascertained by crystallographic analysis. Preliminary biological data candidate this new class of derivatives as a powerful pharmacological tools in the unraveling of TNKS implications in physiopathological conditions.
Glycation Stress and Photo-Aging in Skin (2011)

This article reviews glycation stress as a factor linked to age-related diseases and functional and structural alterations of the skin. Photo-aging and glycation stress are major causes of skin deterioration. Glycation occurs when a reducing sugar, such as glucose or fructose, combines with a protein in a non-enzymatic reaction forming a glycated protein. Further reactions form advanced glycation end products (AGEs), which may accumulate in tissue. AGEs may also bind to a receptor for AGEs (RAGE), thus inducing inflammatory changes in skin and other tissues. The concept of glycation stress includes cellular and tissue responses to reducing sugars and aldehydes, not just to the production of AGEs.Glycation stress may be induced and affected by many factors, including exposure to ultraviolet light, which drastically intensifies AGE accumulation. AGEs modify skin collagen by reducing skin elasticity, and one result is wrinkle formation. AGEs accumulated in skin may be detected using auto-fluorescence (AF); our data from 136 healthy Japanese females shows the AF level is correlated with age.Glycation stress, and subsequently skin aging, may be reduced by managing levels of blood glucose, low-density lipoprotein cholesterol, and triglyceride through an appropriate diet, lifestyle, and intake of anti-glycation materials such as AGE generation inhibitors, AGE decomposers, and AGE receptor antagonists. Study of glycation stress may help identify new anti-aging treatments.
Field Evaluation of a Presence-Absence, Sequential Sampling Plan for Pink Bollworm Eggs (1988)

During 1987, a sequential sampling plan for pink bollworm eggs was field-tested in eight 40-acre fields in the Palo Verde Valley, CA. Final analysis of the sequential procedure, including the time necessary to collect and check all bolls, required an average sampling time of 16 minutes/field, approximately a 70% savings over the fixed sample size of 160 bolls/field. Using the sequential plan, the number of bolls examined averaged 46.75/field. The sequential sampling plan error rate for making no-treat recommendations when a field actually required treatment (i.e., actual egg infestation 6%) averaged only 6.4% throughout the season. A final sequential sampling chart, based on the field validation data, is presented.
Hepatitis-Associated Markers in theAmerican Red Cross Volunteer Blood Donor Population (1980)

From January 1975 to December 1978, 19,140,169 units of blood were collected by the American Red Cross at 57 regional locations. Each unit was tested for hepatitis B surface antigen (HBsAg) by a single commercial radioimmunoassay test system. A total of 15,954 donations were reported reactive, representing a rate of HBsAg reactivity of 0.83/ 1,000 units tested. The rate during 1975 was 0.94/1,000 units tested, decreasing to 0.71/1,000 units tested in 1978 (p<0.005). The prevalence of HBsAg among first-time donors was 2.08/ 1,000 during 1977 and 1978, 2.7 times higher than that calculated for repeat donors (0.77/ 1,000 donors). Substantial geographic variation in the prevalence and rate of detection of HBsAg was observed.
Islet β cell mass in diabetes and how it relates to function, birth, and death (2013)

In type 1 diabetes (T1D) β cell mass is markedly reduced by autoimmunity. Type 2 diabetes (T2D) results from inadequate β cell mass and function that can no longer compensate for insulin resistance. The reduction of β cell mass in T2D may result from increased cell death and/or inadequate birth through replication and neogenesis. Reduction in mass allows glucose levels to rise, which places β cells in an unfamiliar hyperglycemic environment, leading to marked changes in their phenotype and a dramatic loss of glucose-stimulated insulin secretion (GSIS), which worsens as glucose levels climb. Toxic effects of glucose on β cells (glucotoxicity) appear to be the culprit. This dysfunctional insulin secretion can be reversed when glucose levels are lowered by treatment, a finding with therapeutic significance. Restoration of β cell mass in both types of diabetes could be accomplished by either β cell regeneration or transplantation. Learning more about the relationships between β cell mass, turnover, and function and finding ways to restore β cell mass are among the most urgent priorities for diabetes research.
Polarization Effects on the Millimeter Wave Dielectric Properties of Pesticide (2008)

This study investigates the effect of polarization on the dielectric measurements of pesticide. Dispersive Fourier Transform Spectroscopy was utilized to measure the absorption coefficient and refractive index from 180 to 420 GHz. Variations in the results due to polarization and birefringence were investigated by calculating the average value, standard deviation and percentage variations in dielectric data. Noticeable variations in the absorption coefficient data have been observed. The sinusoidal relationship between the dielectric properties and the rotation angle confirms the existence of birefringence effect.
Functional Late Potential Analysis With Exercise Testing to Identify Patients Prone to Ventricular Tachycardia After Myocardial Infarction (1997)

Objective: Exercise induced ischemia or heart rate acceleration may unmask late potentials or provoke functional changes, which might be important factors to improve the low positive predictive value of late potential analysis at rest for postinfarction risk stratification. However, methodological refinements are required to detect late potentials with exercise. Methods: We, therefore, investigated the surface‐electrocardiogram in 100 patients after myocardial infarction (50 with sustained ventricular tachycardia [group I], 50 patients without ventricular arrhythmias [group II], and in 15 normals before and immediately after bicycle exercise test using Spectrotemporal Mapping (STM) with fast Fourier transform (FFT) and Simson method and introduced selective signal averaging. Results: In group I, 30 out of 50 patients showed late potentials at rest, after selective signal averaging also recognizable immediately after exercise in all of these patients, however, with a time‐shift of 18 ± 13 ms into the ST‐segment. Twelve out of 50 patients of group I with only transient late potentials tended to have inducible and recurrent ventricular tachycardia with a shorter cycle length. In group II, 4 out of 50 patients had late potentials at rest and 2 out of 46 patients developed them during exercise. Transient pathological Simson method was associated with transmural ischemia. Conclusions: Thus, detection of the effects of exercise on late potential analysis is possible with selective signal averaging immediately after exercise. Exercise unmasks late potentials not detectable at rest by their time‐shift into the ST‐segment. Using this method, patients that would have been lost with conventional late potential analysis, could be identified.
Improved Muscle Function in Duchenne Muscular Dystrophy using a Combination of L-Arginine and Metformin (2015)

Objective: Duchenne muscular dystrophy (DMD) is the most common and one of the most severe muscular dystrophies presenting with rapidly progressing muscle wasting and premature death. Reduced neuronal nitric oxide synthase (nNOS) activity is thought to be important for the pathophysiology of DMD. In this prospective, open-label, single center proof-of-concept pilot study, we aimed to increase the intramuscular NO concentration to improve the mitochondrial energy metabolism using a novel approach with a combination of l-arginine and metformin.
Transformerless series sag compensation with a cascaded multilevel inverter (2002)

The use of a cascaded multilevel inverter for transformerless sag/dip compensation is investigated. This topology is investigated as a cost-effective means for series sag compensation by eliminating the large injection transformer and output filter components that are used in conventional series injection devices. This prototype inverter is designed for sag compensation of a 250-kVA load. In this design, cost effectiveness plays a major role in the selection of the energy storage and the switching components. Control schemes are discussed for series sag compensation with this multilevel inverter. New control methods for sag compensation and injection are also introduced. A prototype is developed and the control schemes of this sag compensator are successfully verified in the practical results and show successful compensation for sags for different types of loads. The performance of this compensator makes it promising for future power rating upgrade and industrialization.
Scheduling the I/O of HPC Applications Under Congestion (2015)

A significant percentage of the computing capacity of large-scale platforms is wasted because of interferences incurred by multiple applications that access a shared parallel file system concurrently. One solution to handling I/O bursts enlarge-scale HPC systems is to absorb them at an intermediate storage layer consisting of burst buffers. However, our analysis of the Argonne's Mira system shows that burst buffers cannot prevent congestion at all times. Consequently, I/O performances dramatically degraded, showing in some cases a decrease in I/O throughput of 67%. In this paper, we analyze the effects of interference on application I/O bandwidth and propose several scheduling techniques to mitigate congestion. We show through extensive experiments that our global I/O scheduler is able to reduce the effects of congestion, even on systems where burst buffers are used, and can increase the overall system throughput up to 56%. We also show that it outperforms current Mira I/O schedulers.
Blue-green laser diodes with improved crystal quality by using a strained-layer superlattice for the optical guiding layer (1995)

Blue-green laser diodes (LDs) are attractive for such novel media applications as high- density optical recording systems and full color display devices. ZnSe-based II-VI semiconductor LDs have been developed in recent years 1 ), and room temperature continuous- wave operation has been achieved 2 ). These developments have enabled us to examine the various laser structures using this II-VI semiconductor, e.g., a separate-confinement heterostructure (SCH) gain guide laser 1 , 2 ), and a ridge-waveguide laser 3 ).
Motional rotating wave approximation for harmonically trapped particles (2001)

We present a family of generalized unitary transformations that simplifies the Hamiltonian for a harmonically trapped two level atom (or ion) interacting with a plane wave laser field. Novel near resonant single as well as double vibrational phonon dynamical regimes are found. The validity condition of the often used motional rotating wave approximation (MRWA) is examined both numerically and analytically. Large errors are found within typical regimes of MRWA with respect to the motional degrees of freedom. The effects of MRWA in trapped ion systems are shown to be opposite to that of the rotating wave approximation (RWA) in the usual Jaynes-Cummings model. Our study points to a more restrictive condition on particle localization (Lamb-Dicke) parameter for the validity of MRWA in the single phonon dynamical regime. It also sheds new light on quantum information storage and processing with trapped atoms.
Orofacial granulomatosis and nutrition (2014)

The term ‘orofacial granulomatosis’ (OFG) is a descriptor for the presentation of granulomatous inflammation which affects, most noticeably, the lips and face but invariably intraoral features are also present and can include swelling, erythema, nodules, tags and ulcers. The diagnosis is made through oral examination and the gold standard histological diagnostic criteria require the presence of noncasaeating granulomas observed in the biopsies taken from the disease sites. Dietary treatments have involved exclusion diets and have demonstrated some resolution when the offending food can be readily identified. The most frequently used dietary treatment avoids cinnamon and benzoate. This chapter outlines mechanisms involved in dietary avoidance of cinnamon and benzoates in OFG, and tabulates sources of cinnamon and benzoates. It considers the other dietary factors include flavourings, chocolate, tomato and soya.
Videobasierte modellgestützte Objekterkennung für Fahrerassistenzsysteme (2009)

Um den steigenden Anforderungen zukunftiger Fahrerassistenzsysteme an die Qualitat der Informationen uber das lokale Umfeld des eigenen Fahrzeugs zu entsprechen, werden in dieser Arbeit Algorithmen zur videobasierten Fahrzeug- und Fahrspurerkennung entwickelt. Die Verfahren zur Fahrzeugdetektion kombinieren Expertenwissen mit modernen Maschinenlernverfahren in einem Gesamtsystem, das an verschiedene Problemstellungen zur videobasierten Objekterkennung angepasst werden kann. Durch den Einsatz spezieller Sensormodelle wird das anschliesende multisensorielle Verfolgen von Fahrzeugen in einem Kalman-Filter basierten Objekttracker ermoglicht.

Ein Algorithmus zur videobasierten Fahrspurverfolgung wird durch robustheitssteigernde Masnahmen erweitert, so dass eine automatische Spurfuhrung des Versuchsfahrzeugs auch bei komplexen Fahrszenarien ermoglicht wird.