gebhart/patrepeval huggingface dataset:
Defining the index lesion for salvage partial gland ablation after radiation therapy for localized prostate cancer. (2017)

105 Background: Our objective was to evaluate the impact of MRI and systematic biopsy characteristics to identify the index lesion for salvage partial gland ablation using tumor maps from whole mount slides of salvage radical prostatectomy (sRP) specimen. Methods: We identified 225 patients who underwent sRP between 2000 and 2014 and a tumor map was created from whole-mount slides in 77 patients. Among these patients, we selected men with a priori pre-treatment criteria considered eligible for PGA, including, biopsy proven unilateral disease concordant with a region of interest (ROI) on MRI, and excluding men with imaging suspicious for extra-capsular extension (ECE), seminal vesicle Invasion (SVI) or lymph node involvement (LNI). We describe the correlation between pre-treatment clinical characteristics and final radical prostatectomy whole mount specimen to select men eligible for PGA defined as hemi-gland ablation. Results: Among 77 patients with a tumor map of entirely-submitted and whole-mounted specimens, 15 patients were determined to be eligible for partial gland ablation based on pre-treatment clinical characteristics. The mean age was 60 years and median time from primary RT was 48 months. The median (IQR) tumor volume of the index lesion was 0.3 (0.4) cc. The location of the index lesion was determined to be the apex, mid-gland and base in 77%, 100% and 15% of patients, respectively. The median distance of the index tumor to the urethra was 0.5 (0.2) cm. The index tumor was confined to one lobe and concordant to the biopsy pathology and MRI data in all 15 patients (100%). There was no ECE, LNI or SVI identified in the sRP specimens. To account for those patients who did not have a tumor map of the whole-mount specimen, a sensitivity analysis was performed and determined that the clinical characteristics of the 77 patients with tumor maps were comparable to the entire 225 sRP cohort. Conclusions: Clinical characteristics guided by biopsy findings and MRI data can be used to select men for PGA with recurrent localized prostate cancer after radiation therapy and based on tumor maps from sRP specimen, we propose that salvage hemi-gland ablation including periurethral tissue is feasible.
Ascochalasin, a New Cytochalasin from Ascochyta heteromorpha (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAscochalasin, a New Cytochalasin from Ascochyta heteromorphaR. Capasso, A. Evidente, A. Ritieni, G. Randazzo, M. Vurro, and A. BottalicoCite this: J. Nat. Prod. 1988, 51, 3, 567–571Publication Date (Print):May 1, 1988Publication History Published online1 July 2004Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/np50057a019https://doi.org/10.1021/np50057a019research-articleACS PublicationsRequest reuse permissionsArticle Views250Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rotation and translation registration of bandlimited interferometric images using a chirp z-transform (2016)

Image reconstruction algorithms for wide-field spatio-spectral interferometry require knowledge of registration parameters associated with low-resolution image measurements at various baseline orientations, such that the images can be registered to within the fine resolution of the final desired image. We have developed an image registration procedure that combines a nonlinear optimization algorithm with the sub-pixel precision of chirp z-transform resampling, particularly for rotation and translation, of bandlimited images with non-radially symmetric aberrations. We show the accuracy of this image registration technique on simulated images that have a complexity comparable to scenes observed experimentally with NASA’s wide-field imaging interferometry testbed. Registration to within a tenth of a pixel for translation and within three arcminutes for rotation is demonstrated at the largest simulated noise levels.
Statistical Model Checking of Distance Fraud Attacks on the Hancke-Kuhn Family of Protocols (2018)

Distance-bounding (DB) protocols protect against relay attacks on proximity-based access control systems. In a DB protocol, the verifier computes an upper bound on the distance to the prover by measuring the time-of-flight of exchanged messages. DB protocols are, however, vulnerable to distance fraud, in which a dishonest prover is able to manipulate the distance bound computed by an honest verifier. Despite their conceptual simplicity, devising a formal characterization of DB protocols and distance fraud attacks that is amenable to automated formal analysis is non-trivial, primarily because of their real-time and probabilistic nature. In this work, we introduce a generic, computational model, based on Rewriting Logic, for formally analyzing various forms of distance fraud, including recently identified timing attacks, on the Hancke-Kuhn family of DB protocols through statistical model checking. While providing an insightful formal characterization on its own, the model enables a practical formal analysis method that can help system designers bridge the gap between conceptual descriptions and low-level designs. In addition to accurately confirming known results, we use the model to define new attack strategies and quantitatively evaluate their effectiveness under realistic assumptions that would otherwise be difficult to reason about manually.
Analysis of Bacteriolytic Activity Patterns, a Novel Approach to the Taxonomy of Enterococci (1992)

The bacteriolytic activities of different group D streptococcal species on various media and substrates were studied. Our results showed that all of the enterococcal species which we tested had bacteriolytic activity on at least one of the media used, while the group D nonenterococcal species had no such activity. In addition, using culture media containing different additives and different pH values, we defined seven major groups of bacteriolytic activity (lyogroups), each of which overlapped with one species (four lyogroups), two species (two lyogroups), or four species (one lyogroup). The detection of enterococcal lyogroups proved to be as reliable for species identification as the conventional methods presently in use.
Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica (2005)

Intractable hiccup and nausea (IHN) was found in eight of 47 cases of relapsing neuromyelitis optica (NMO) (17%) but in none of 130 cases of multiple sclerosis (MS). IHN resolved with methylprednisolone. In six cases, MRI detected linear medullary lesions involving the pericanal region, the area postrema, and the nucleus tractus solitarius. Like long and centrally located myelitis, a linear medullary lesion causing IHN may distinguish NMO from MS.
Chemoattractant-mediated stimulation of the respiratory burst in human polymorphonuclear leukocytes may require appearance of protein kinase activity in the cells' particulate fraction (1986)

Low doses of aliphatic alcohols produce divergent effects on the function of chemoattractant receptors on human polymorphonuclear leukocytes (PMNs) since they enhance chemotaxis but inhibit stimulation of superoxide production by chemoattractants. As such, alcohols can provide useful pharmacologic tools to probe the mechanisms of stimulus-response coupling in leukocytes. A role for protein kinase C has been implicated in the activation of the respiratory burst in PMNs. Although the vast majority of this enzyme activity is located in the cytosolic fraction of unactivated PMNs, protein kinase C activity appears in the particulate fraction of the cells when they are stimulated to produce superoxide by either chemoattractants or by phorbol myristate acetate (PMA). Doses of the alcohols that selectively inhibited stimulation of superoxide production by chemoattractants also inhibited the appearance of protein kinase C activity as well as an undefined protein kinase activity in the particulate fraction of the cells. In contrast, the alcohols did not affect either the ability of PMA to stimulate the production of superoxide in PMNs nor the appearance of protein kinase activity in the cells' particulate fraction. PMA is known to bind and activate protein kinase C directly, thus bypassing receptor-mediated events. These data suggest that alcohols inhibit the stimulation of the respiratory burst by chemoattractants in PMNs by blocking the ability of receptor occupancy to induce the appearance of protein kinase activity in particulate fractions. These results moreover suggest that the appearance of protein kinase activity in the particulate fraction may be required for activation of the respiratory burst in PMNs.
Studies on the Oxidation of Nucleoside Hydrogenphosphonates (1987)

Abstract Oxidation of nucleoside H-phosphonate diesters has been investigated using dipyridyl disulphide, hexachloroacetone and iodine, under various reaction conditions.
Parallel Poisson disk sampling with spectrum analysis on surfaces (2010)

The ability to place surface samples with Poisson disk distribution can benefit a variety of graphics applications. Such a distribution satisfies the blue noise property, i.e. lack of low frequency noise and structural bias in the Fourier power spectrum. While many techniques are available for sampling the plane, challenges remain for sampling arbitrary surfaces. In this paper, we present new methods for Poisson disk sampling with spectrum analysis on arbitrary manifold surfaces. Our first contribution is a parallel dart throwing algorithm that generates high-quality surface samples at interactive rates. It is flexible and can be extended to adaptive sampling given a user-specified radius field. Our second contribution is a new method for analyzing the spectral quality of surface samples. Using the spectral mesh basis derived from the discrete mesh Laplacian operator, we extend standard concepts in power spectrum analysis such as radial means and anisotropy to arbitrary manifold surfaces. This provides a way to directly evaluate the spectral distribution quality of surface samples without requiring mesh parameterization. Finally, we implement our Poisson disk sampling algorithm on the GPU, and demonstrate practical applications involving interactive sampling and texturing on arbitrary surfaces.
A microphotometer for microradiography (1953)

The microphotometer records the transmission in the primary image of an object down to 2-3 μ2 under visual control. The electrical construction gives a linear amplification in the transmission range actually used. The object is moved across the measuring light beam and, synchronously, the transmission curve is recorded by the writer. The accuracy of the apparatus was found to be less than 1%. When the test included the photographic-photometric procedure in X-ray microradiography the standard error was ±1.5%.
Simulation of a 50-GeV PWFA stage (2005)

Abstract. The plasma afterburner has been proposed as a possible advanced acceleration scheme for a future linear collider. In this concept, a high energy electron(or positron) drive beam from an existing linac such as the SLC will propagate in a plasma section of density about one order of magnitude lower than the peak beam density. The particle beam generates a strong plasma wave wakefield which has a phase velocity equal to the velocity of the beam and this wakefield can be used to accelerate part of the drive beam or a trailing beam. Several issues such as the efficient transfer of energy and the stable propagation of the particle beam in the plasma are critical to the afterburner concept. We investigate the nonlinear beam-plasma interactions in such scenario using a new 3D particle-in-cell code called QuickPIC. Preliminary simulation results for electron acceleration, beam-loading and hosing instability will be presented. I
Down‐regulation by tumor necrosis factor‐α of neutrophil cell surface expression of the sialophorin CD43 and the hyaluronate receptor CD44 through a proteolytic mechanism (1991)

Adhesion of human neutrophils to endothelial cells is a crucial step during migration to the extravascular sites of inflammation. A large number of molecules, including the CD44 and LAM-1 antigens, have been described to participate in this process. We have investigated the regulation by human recombinant tumor necrosis factor-alpha (TNF-alpha) of human neutrophil plasma membrane expression of both CD44 and LAM-1 adhesion molecules, as well as that of CD43 sialophorin, which has been involved in adhesion and activation of leukocytes. The expression of these three antigens was down-regulated in neutrophils upon TNF-alpha treatment, as determined by immunofluorescence and immunoprecipitation experiments. However, the expression of other cell surface molecules, such as CD45 or CD11b, was up-regulated. Similar regulatory effects were also observed upon neutrophil treatment with other activating agents such as the chemoattractant peptide formyl-Met-Leu-Phe, the calcium ionophore A23187, or the phorbol ester phorbol 12-myristate 13-acetate. Protease inhibitors virtually abrogated the TNF-alpha-induced down-regulation of CD43 and CD44 expression, but not that of LAM-1, suggesting the involvement of a protease activity in this process. These results underline the role of TNF-alpha on the differential regulation of cell surface expression of neutrophil adhesion molecules, thus implying modifications in the neutrophil adhesive properties.
Effects of inflammation and acute beta-agonist inhalation on beta 2-AR signaling in human airways (1996)

Although alterations in beta 2-adrenergic receptor (AR) responsiveness may in part explain reports linking deterioration of asthma control with beta-agonist treatment of asthmatics, few data exist on beta 2-AR regulation in human airway cells. We have employed a bronchoscopy model to examine inflammation- and beta-agonist-induced alterations in human bronchial epithelial cell beta 2-AR density and responsiveness. Allergic asthmatic subjects participated in 2-day protocols examining airways before and 24 h after segmental antigen challenge (SAC) with ragweed. To assess the effect of acute beta-agonist exposure, bronchoscopies were performed both with (+ beta-Ag) and without (-beta-Ag) inhalation of beta-agonist 30 min before the procedure. Measurements of inflammatory cell infiltration were obtained by analysis of bronchoalveolar lavage fluid, and beta 2-AR density and responsiveness were examined in bronchial epithelial cells obtained by bronchoscopic brushing. Neither SAC nor acute beta-agonist administration alone significantly affected epithelial cell beta 2-AR density. beta-Agonist-stimulated adenosine 3', 5'-cyclic monophosphate (cAMP) generation was significantly lower in the + beta-Ag groups compared with the-beta-Ag group, demonstrating acute agonist-specific beta 2-AR desensitization in vivo. SAC caused a small, statistically insignificant reduction in beta-Agonist-stimulated cAMP production in both -beta-Ag or + beta-Ag groups. These lata suggest that acute beta-agonist inhalation, but not airway inflammation, significantly reduces maximal beta 2-AR responsiveness in airway cells.
Excitonic Zeeman Splittings in Colloidal CdSe Quantum Dots Doped with\n Single Magnetic Impurities (2017)

Doping a semiconductor quantum dot with just a single impurity atom can\ncompletely transform its physical properties. Here, we report and analyze the\nmagnetic circular dichroism (MCD) spectra of colloidal CdSe quantum dot samples\ncontaining on average fewer than one Mn2+ per quantum dot. Even at this\nsub-single-dopant level, the low-temperature low-field data are dominated by\nimpurity-induced Zeeman splittings caused by dopant-carrier sp-d exchange.\nUnlike in more heavily doped quantum dots, however, the MCD intensity at the\nfirst CdSe exciton shows a field-induced sign flip as the field strength is\nincreased, reflecting competition between sp-d exchange and the intrinsic\nZeeman splittings of comparable magnitude. Most unusually, the competition\nbetween these two effects leads to a large apparent shift in the first MCD peak\nmaximum, which we show is attributable to a difference in sign of the intrinsic\nexcitonic g factor between the first and second excitons. Finally, the sp-d and\nintrinsic contributions to the excitonic Zeeman splittings each exhibit unique\nmagnetic-field and temperature dependencies, allowing the MCD spectra of\nundoped, singly doped, and bi-doped quantum dot sub-ensembles to be analyzed.\n
Block coded modulation for the QS-CDMA system (2004)

This paper proposes a novel introduction of the multidimensional multilevel block coded modulation (ML-BCM) to the quasi-synchronous CDMA (QS-CDMA) system, where the code delay uncertainty at the base station is limited to a small number of chips. To improve the performance of the QS-CDMA system, we employ the Leech-lattice based 24-dimensional BCM in the overall BCM-QS-CDMA modulation. The resulting transmitted constellation is more robust to fading. Computer simulation results show a significant coding gain compared to the uncoded and convolutional code based QS-CDMA systems.
Analyse des courbes d'absorption et de dichroïsme circulaire magnétique : Application aux ions Pb2 + et Ag- dans les halogénures alcalins (1970)

On propose une méthode permettant d'analyser finement des courbes complexes d'absorption et de dichroïsme circulaire magnétique. On obtient ainsi les paramètres caractéristiques de chacune des composantes. La méthode est appliquée aux spectres des ions Pb2+ et Ag- dans les halogénures alcalins. On démontre ainsi que la dégénérescence du premier état excité est complètement levée.
Autographa californica M nucleopolyhedrovirus early GP64 synthesis mitigates developmental resistance in orally infected noctuid hosts (2004)

The unusual early synthesis of the Autographa californica M nucleopolyhedrovirus (AcMNPV) budded virus (BV) structural protein GP64 is an important virulence factor during oral infection of Heliothis virescens larvae. Considering the breadth of the AcMNPV host range, the importance of early GP64 synthesis in orally infected permissive hosts (Trichoplusia ni and Spodoptera exigua) from subfamilies other than that of H. virescens was assessed. An AcMNPV recombinant, having wild-type early and late GP64 synthesis, was compared with one in which only late GP64 synthesis occurred. Early GP64 synthesis was found to have more of an effect on virulence in orally inoculated T. ni than S. exigua and that virulence was dependent on two factors: the ability of the host to slough occlusion-derived virus (ODV)-infected midgut cells and the rapidity with which BV was transmitted to the tracheal cells. In both host species, insects inoculated orally with the control virus transmitted BV to tracheal cells hours before those inoculated with the gp64 temporal mutant. Moreover, with early GP64 synthesis, the lag between the onset of viral gene expression in midgut and tracheal cells was only 3-4 h, supporting the conclusion that in these insects, the first systemic infections arose from ODV-derived nucleocapsids repackaged as BV. These results provide further empirical proof that early GP64 synthesis is a component of a unique and selectively advantageous baculovirus infection strategy for exploiting larval lepidopterans by counteracting developmental resistance.
Analysis by Classic Scalar Approach (2007)

Auteur de l'ouvrage : Philippe de Larminat
Regulatory Aspects of &omega;3 Fatty Acid Labelling in Canada (1998)

Research Articles| October 03 2008 Die Natur der sog. Myoblastentumoren. Subject Area: Further Areas , Oncology , Pathology and Cell Biology C. Wegelin C. Wegelin (Aus dem Pathologisch-Anatomischen Institut Bern.) Search for other works by this author on: This Site PubMed Google Scholar Schweizerische Zeitschrift für allgemeine Pathologie und Bakteriologie (1947) 10 (6): 631–653. https://doi.org/10.1159/000159665 Article history Published Online: October 03 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation C. Wegelin; Die Natur der sog. Myoblastentumoren.. Schweizerische Zeitschrift für allgemeine Pathologie und Bakteriologie 1 June 1947; 10 (6): 631–653. https://doi.org/10.1159/000159665 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsSchweizerische Zeitschrift für allgemeine Pathologie und Bakteriologie Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1947Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.