gebhart/patrepeval huggingface dataset:
Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening (2011)

Altogether the data obtained provides the most extensive survey obtained so far for gene expression and metabolites accumulated during grape ripening. Moreover, it highlighted information obtained in a poorly known variety exhibiting particular characteristics that may be cultivar specific or dependent upon climatic conditions. Several genes were identified that had not been previously reported in the context of grape ripening namely genes involved in carbohydrate and amino acid metabolisms as well as in growth regulators; metabolism, epigenetic factors and signaling pathways. Some of these genes were annotated as receptors, transcription factors, and kinases and constitute good candidates for functional analysis in order to establish a model for ripening control of a non-climacteric fruit.
Pharmacokinetics of tulathromycin after single and multiple subcutaneous injections in domestic goats (<i>Capra aegagrus hircus</i>) (2011)

Tulathromycin, a novel triamilide in the macrolide class, is labeled for treatment of bacterial pneumonia in cattle and swine. This manuscript evaluates pharmacokinetics of tulathromycin in goats. In two different studies, six juvenile and ten market-age goats received a single injection of 2.5 mg/kg of tulathromycin subcutaneously; in a third study, 18 juvenile goats were treated with 2.5, 7.5, or 12.5 mg/kg tulathromycin weekly with three subcutaneous injections. Pharmacokinetic parameters estimated from the plasma concentrations from single injections were similar between the two groups of goats and to previously reported parameters in cattle and swine. Mean terminal half-lives were 59.1 ± 7.6 and 61.2 ± 8.7 h for juvenile and market-age goats, respectively. In the multi-dose study, pharmacokinetic parameters estimated from plasma concentrations demonstrated significant differences at P < 0.05 among repeated injections but not among doses. Overall, pharmacokinetic parameters in goats are similar to those reported in cattle and swine, and tulathromycin may prove a useful drug for treating respiratory disease in goats.
Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes (2004)

Inhibition of cyclin A- and cyclin E-associated cyclin-dependent kinase-2 (CDK2) activities is an effective way of selective induction of apoptotic cell death via the E2F pathway in tumour cells. The cyclin groove recognition motif (CRM) in the natural CDK-inhibitory (CDKI) tumour suppressor protein p27KIP1 was used as the basis for the design and synthesis of a series of cyclic peptides whose biological activity and structural characterisation by NMR and X-ray crystallography is reported. Whereas linear p27KIP1 sequence peptides were comparatively ineffective, introduction of side chain-to-tail constraints was found to be productive. An optimal macrocyclic ring size for the conformational constraint was determined, mimicking the intramolecular H-bonding system of p27. Molecular dynamics calculations of various macrocycles suggested a close correlation between ring flexibility and biological activity. Truncated inhibitor peptide analogues also confirmed the hypothesis that introduction of a cyclic conformational constraint is favourable in terms of affinity and potency. The structural basis for the potency increase in cyclic versus linear peptides was demonstrated through the determination and interpretation of X-ray crystal structures of complexes between CDK2/cylin A (CDK2A) and a constrained pentapeptide.
Joint blind signal detection and carrier recovery over fading channels (2002)

A scheme of joint blind signal detection and carrier recovery is developed for intersymbol interference channels. Using a blind sequence estimation scheme, the proposed approach does not require explicit channel identification. It shows robustness against timing error and carrier phase uncertainty. The efficacy of the proposed approach is demonstrated in a simulation involving frequency selective fast fading channel with substantial Doppler shifts.
Dark HORSE 2 Quick-Look Report: Real-time Detection of Military Ground Targets Using an Infrared Hyperspectral Imaging Sensor (1999)

Abstract : Researchers at the Naval Research Laboratory (NRL) have successfully demonstrated autonomous, real time detection of military ground targets using a long-wave infrared hyperspectral imaging sensor. The work was performed under NRL's Dark HORSE effort, the culmination of a four-year Multispectral Overhead IR/EO Surveillance (MOVIES) program to develop real-time hyperspectral detection, cueing, target location, and target designation capabilities. The following provides an overview of Dark HORSE 2 (DH2), the recently completed second phase of the Dark HORSE effort. The DH2 hyperspectral sensor system is described in detail along with a recent field experiment in which it was employed. The system hardware components, software interface and processing methods are described in detail. In closing, a description of the test flight profiles is given and a preliminary analysis of the collected data is presented.
The EUROTRANS Project (2010)

Accelerator Driven Systems (ADS) for nuclear waste transmutation require proton drivers with energies between 600 and 800 MeV and beam currents of several mA for demonstrators and up to 25 mA for large industrial systems. Within the EUROTRANS project a 600 MeV linac has been designed to meet the stringent requirements regarding reliability, availability and extreme low beam losses. The first accelerating section using the novel CH‐cavity accelerates the beam to 17 MeV at the injection point into the main linac. The intermediate energy section (17–100 MeV) of the main linac consists of superconducting independently phased spoke‐type cavities followed by the high energy section consisting of 704 MHz superconducting elliptical cavities. The paper covers the development of the linac, prototype testing and reliability considerations of the whole EUROTRANS project.
Progression-Free Survival as a Primary Endpoint in Clinical Trials of Metastatic Colorectal Cancer (2011)

In recent years, significant advances have been made in the management of metastatic colorectal cancer. Traditionally, an improvement in overall survival has been considered the “gold standard”—the most convincing measure of efficacy. However, overall survival requires larger patient numbers and longer follow-up and may often be confounded by other factors, including subsequent therapies and crossover. Given the number of active therapies for potential investigation, demand for rapid evaluation and early availability of new therapies is growing. Progression-free survival is regarded as an important measure of treatment benefit and, compared with overall survival, can be evaluated earlier, with fewer patients and no confounding by subsequent lines of therapy. The present paper reviews the advantages, limitations, and relevance of progression-free survival as a primary endpoint in randomized trials of metastatic colorectal cancer.
Nocturnal reduction of blood pressure and the antihypertensive response to a diuretic or angiotensin converting enzyme inhibitor in obese hypertensive patients (1998)

During a 12-week, multicenter study to evaluate the efficacy and safety of lisinopril and hydrochlorothiazide (HCTZ) for the treatment of obesity-related hypertension, ambulatory blood pressure (ABP) monitoring was performed both at baseline and at study completion in 124 patients. Patients were randomized to three groups: placebo, lisinopril (10, 20, or 40 mg/day), or HCTZ (12.5, 25, or 50 mg/day). All groups were matched with regard to sex, race, age, body mass index, and waist/hip ratio. The primary analysis of ABP data revealed that both lisinopril and HCTZ effectively lowered mean 24-h systolic (SBP) and diastolic (DBP) blood pressure compared with placebo, (mean change from baseline SBP/DBP: -12.0/-8.2, -10.6/-5.5, and -0.3/-0.5 mm Hg, respectively); however, lisinopril lowered DBP better than HCTZ (P < .05). Secondary analyses of groups revealed that men responded better to lisinopril than HCTZ (-11.9/-7.3 v -6.6/-3.5 mm Hg, respectively), whereas women responded well to both drugs. White patients responded better to lisinopril than HCTZ, whereas black patients showed a significant response to HCTZ only. Response to treatment was also influenced by patient classification of 24-h blood pressure profiles, ie, "dipper" or "nondipper." Overall, the majority of obese hypertensives were nondippers. Nondippers (n = 82) responded well to both drugs (-10.4/-6.9 v -12.5/-5.7 mm Hg, P < .05 v placebo), whereas dippers (n = 42) responded to lisinopril (-11.7/ -9.4 mm Hg, P < .05 v placebo and HCTZ), but not HCTZ (-5.6/-4.1 mm Hg, P = NS v placebo). Results of 24-h ABP data show that both lisinopril and HCTZ are effective therapies for obesity-related hypertension and that response to treatment is influenced by sex, race, and dipper/nondipper status.
Differences in Admission Blood Pressure Among Causes of Intracerebral Hemorrhage (2019)

Background and Purpose- It is unknown whether admission systolic blood pressure (SBP) differs among causes of intracerebral hemorrhage (ICH). We sought to elucidate an association between admission BP and ICH cause. Methods- We compared admission SBP across ICH causes among patients in the Cornell Acute Stroke Academic Registry, which includes all adults with ICH at our center from 2011 through 2017. Trained analysts prospectively collected demographics, comorbidities, and admission SBP, defined as the first recorded value in the emergency department or on transfer from another hospital. ICH cause was adjudicated by a panel of neurologists using the SMASH-U criteria. We used ANOVA to compare mean admission SBP among ICH causes. We used multiple linear regression to adjust for age, sex, race, Glasgow Coma Scale score, and hematoma size. In secondary analyses, we compared hourly SBP measurements during the first 72 hours after admission, using mixed-effects linear models adjusted for the covariates above plus antihypertensive agents. Results- Among 484 patients with ICH, admission SBP varied significantly across ICH causes, ranging from 138 (±24) mm Hg in those with structural vascular lesions to 167 (±35) mm Hg in those with hypertensive ICH (<i>P</i><0.001). The mean admission SBP in hypertensive ICH was 17 (95% CI, 11-24) mm Hg higher than in ICH of all other causes combined. These differences remained significant after adjustment for age, sex, race, Glasgow Coma Scale score, and hematoma size (<i>P</i><0.001), and this persisted throughout the first 72 hours of hospitalization (<i>P</i><0.001). Conclusions- In a single-center ICH registry, SBP varied significantly among ICH causes, both on admission and during hospitalization. Our results suggest that BP in the acute post-ICH setting is at least partly associated with ICH cause rather than simply representing a physiological reaction to the ICH itself.
Charge Patterns as Templates for the Assembly of Layered Biomolecular Structures (2006)

Electric fields are used to guide the assembly of biomolecules in predefined geometric patterns on solid substrates. Local surface charges serve as templates to selectively position proteins on thin-film polymeric electret layers, thereby creating a basis for site-directed layered assembly of biomolecular structures. Charge patterns are created using the lithographic capabilities of an atomic force microscope, namely by applying voltage pulses between a conductive tip and the sample. Samples consist of a poly(methyl methacrylate) layer on a p-doped silicon support. Subsequently, the sample is developed in a water-in-oil emulsion, consisting of a dispersed aqueous phase containing biotin-modified immunoglobulinG molecules, and a continuous nonpolar, insulating oil phase. The electrostatic fields cause a net force of (di)electrophoretic nature on the droplet, thereby guiding the proteins to the predefined locations. Due to the functionalization of the immunoglobulinG molecules with biotin-groups, these patterns can now be used to initiate the localized layer-by-layer assembly of biomolecules based on the avidin-biotin mechanism. By binding 40 nm sized biotin-labelled beads to the predefined locations via a streptavidin linker, we verify the functionality of the previously deposited immunoglobulinG-biotin. All assembly steps following the initial deposition of the immunoglobulinG from emulsion can conveniently be conducted in aqueous solutions. Results show that pattern definition is maintained after immersion into aqueous solution.
Analysis of battery charger topologies for an electric vehicle (2012)

This article focuses on fast chargers of electric vehicles. One of the crucial parts of a fast charger is the secondary charging converter that must be able to regulate efficiently battery charge voltage and current. To be able to use the electric vehicle battery as a temporary energy storage in the electric grid, the topology of a charging converter must enable a bidirectional energy flow. Bidirectional converters need an additional boost circuit to stabilize the battery voltage while draining energy from it. Class 3 unidirectional charging converters could be realized with a current doubler rectifier topology and bidirectional ones with a controllable full-bridge rectifier/inverter, resulting from its advantage over the current doubler in this operational mode. A quasi Z source could be used as a filter/boost circuit.
A longitudinal study of information system threat categories (2005)

Taxonomies of information security threats usually distinguish between accidental and intentional sources of system risk. Security reports have paid a great deal of attention in recent years to the growing problem of hacking and intentional abuse. The prevalence of these reports suggests that hacking has become a more severe problem in relation to other security threats, such as human error. In this paper, we report on research that addresses this question: "How have changes over time in the frequency of hacking and other intentional forms of security threats affected the validity of information systems risk management taxonomies?" We replicate a simple study of the proportions of categories of security threats that was originally completed in 1993. Comparing the results from the replicated study with the results from the original study, we find that the proportions of threat categories have, in contradiction with the popular perception, remained relatively stable over the past decade. These results indicate that human error remains a significant and poorly recognized issue for information systems security. We propose and validate an elaborated taxonomy of information security threats that provides additional insight into human error as a significant source of security risk.
Model reactions of amine curing of glycidylamine epoxy resins: Homopolymerization of <i>N</i>‐methylglycidylaniline (1992)

Abstract The kinetics of homopolymerization of the monofunctional epoxide N ‐methylglycidylaniline in the presence of a tertiary amine or an amino alcohol has been followed by reversed phase high performance liquid chromatography and size exclusion chromatography. The reaction products were identified by mass spectrometry using potassium ionization of desorbed species (K + IDS). 1,3‐Di‐ N ‐methylanilino‐2‐propanol (P) was the main reaction product and low molecular weight oligomers with M n > 600 were also formed. The molecular weight and fraction of oligomers decrease with increasing concentration of the initiator. The suggested complex reaction mechanism involves formation of four stable oligomeric series initiated by reaction of the epoxide with either an OH group of (a) the amino alcohol, (b) product P, (c) traces of water, or (d) the tertiary amine to form ionic species resulting in the ionic propagation. Regeneration of the initiator and formation of new initiating centers during the polymerization are the causes of low molecular weights of oligomers. © 1992 John Wiley & Sons, Inc.
The Simplest Phase Equilibrium Examples and Some Simple Estimating Rules (2012)

This chapter contains sections titled: Some General Statements About Equilibrium The Simplest Example of Phase Equilibrium The Next Level of Complexity in Phase Equilibrium Some Simple Estimating Rules: Raoult's and Henry's “Laws” The General Two-Phase Equilibrium Calculation Some Simple Applications of Raoult's and Henry's Laws The Uses and Limits of Raoult's and Henry's Laws Summary References
Use of temporally coincident ultraviolet laser pulses of two different wavelengths to ablate organic polymers (1990)

The etching of polymethyl methacrylate (PMMA), by pulsed ultraviolet laser radiation [20-ns full width at half maximum (FWHM), 193 nm] can be increased more than threefold by overlapping both spatially and temporally laser pulses of 308 nm (20 ns FWHM) along with the 193 nm pulses. At a constant fluence of 193 nm, increasing the fluence of the 308 nm pulses progressively increases the etch depth/pair of pulses even though the fluence of the 308 nm radiation is kept below the value at which it would etch the polymer by itself at 1 Hz repetition rate. When a time delay of +300 to −400 ns is introduced between the two pulses, the 193 nm pulse being set as time zero, the enhancement due to pairing the pulses is found to be a maximum at nearly total overlap. A similar enhancement in the etching of PMMA by pulsed 248-nm laser radiation can be achieved by mixing 308 nm pulses with the 248 nm, and in the etching of polyethylene terephthalate, by mixing 351-nm laser pulses with 308-nm laser pulses. Chemical analysis of the solid polymeric product from the laser ablation of PMMA by 248 and 308 nm alone, and by a mixture of 248 and 308 nm laser radiation shows that the mixed laser radiation etches in a way that is chemically similar to pulsed 248-nm laser light and the effect can probably be attributed to an enhancement of the photoablation process.
Optically pure pyrethroids labeled with deuterium and tritium in the methylcyclopentenonyl ring (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptically pure pyrethroids labeled with deuterium and tritium in the methylcyclopentenonyl ringMichael Elliott and John E. CasidaCite this: J. Agric. Food Chem. 1972, 20, 2, 295–299Publication Date (Print):March 1, 1972Publication History Published online1 May 2002Published inissue 1 March 1972https://pubs.acs.org/doi/10.1021/jf60180a005https://doi.org/10.1021/jf60180a005research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A facile approach to prepare a dual functionalized DNA based material in a bio-deep eutectic solvent (2014)

DNA (Salmon testes) was functionalized by Fe3O4 nanoparticles and protonated layered dititanate sheets (H2·Ti2O5·H2O) in a mixture of choline chloride and ethylene glycol (a deep eutectic solvent) to yield a hybrid material having magnetic and antibacterial properties. Ti sheets were found to interact with the phosphate moieties, while Fe interacted with the base pair of DNA in the hybrid material.
Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries (2003)

Elevation of lung capillary pressure causes exocytosis of the leukocyte adhesion receptor P-selectin in endothelial cells (ECs), indicating that lung ECs generate a proinflammatory response to pressureinduced stress. To define underlying mechanisms, we followed the EC signaling sequence leading to P-selectin exocytosis through application of real-time, in situ fluorescence microscopy in lung capillaries. Pressure elevation increased the amplitude of cytosolic Ca 2+ oscillations that triggered increases in the amplitude of mitochondrial Ca 2+ oscillations and in reactive oxygen species (ROS) production. Responses to blockers of the Ca 2+ oscillations and of mitochondrial electron transport indicated that the ROS production was Ca 2+ dependent and of mitochondrial origin. A new proinflammatory mechanism was revealed in that pressure-induced exocytosis of P-selectin was inhibited by both antioxidants and mitochondrial inhibitors, indicating that the exocytosis was driven by mitochondrial ROS. In this signaling pathway mitochondria coupled pressure-induced Ca 2+ oscillations to the production of ROS that in turn acted as diffusible messengers to activate P-selectin exocytosis. These findings implicate mitochondrial mechanisms in the lung's proinflammatory response to pressure elevation and identify mitochondrial ROS as critical to P-selectin exocytosis in lung capillary ECs.
Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion (2016)

Abnormal choline phospholipid metabolism is associated with oncogenesis and tumor progression. We have investigated the effects of targeting choline phospholipid metabolism by silencing two glycerophosphodiesterase genes, GDPD5 and GDPD6, using small interfering RNA (siRNA) in two breast cancer cell lines, MCF-7 and MDA-MB-231. Treatment with GDPD5 and GDPD6 siRNA resulted in significant increases in glycerophosphocholine (GPC) levels, and no change in the levels of phosphocholine or free choline, which further supports their role as GPC-specific regulators in breast cancer. The GPC levels were increased more than twofold during GDPD6 silencing, and marginally increased during GDPD5 silencing. DNA laddering was negative in both cell lines treated with GDPD5 and GDPD6 siRNA, indicating absence of apoptosis. Treatment with GDPD5 siRNA caused a decrease in cell viability in MCF-7 cells, while GDPD6 siRNA treatment had no effect on cell viability in either cell line. Decreased cell migration and invasion were observed in MDA-MB-231 cells treated with GDPD5 or GDPD6 siRNA, where a more pronounced reduction in cell migration and invasion was observed under GDPD5 siRNA treatment as compared with GDPD6 siRNA treatment. In conclusion, GDPD6 silencing increased the GPC levels in breast cancer cells more profoundly than GDPD5 silencing, while the effects of GDPD5 silencing on cell viability/proliferation, migration, and invasion were more severe than those of GDPD6 silencing. Our results suggest that silencing GDPD5 and GDPD6 alone or in combination may have potential as a new molecular targeting strategy for breast cancer treatment. Copyright © 2016 John Wiley & Sons, Ltd.