gebhart/patrepeval huggingface dataset:
The Effect of Soluble Lubricant on Surface Imprinting in Temper Rolling by 4Hi Rolling Mill (2008)

The surface roughness of carbon steel sheets is controlled by dull roll surface imprinting in temper rolling. In most cases, a dry condition or a lubricant is applied as a lubrication state in temper rolling. However, the oil film of the lubricant and its lubricating ability of lubricant have not been clarified. In this study, the effect of lubricant on surface imprinting was investigated in temper rolling as three lubrication states. Temper rolling experiments for as-annealed low carbon steel strips and as-annealed high carbon steel strips were conducted in the range of 1 to 3% in reduction, using the 4Hi rolling mill. Non lubricant (dry condition), water soluble lubricant and mineral oil were applied as lubrication states. A shot dull roll and an electric-discharged dull roll were employed. Surface microstructures of temper rolled strips were observed directly, as well as surface textures in terms of mean roughness (Ra), three dimensional textures, cross section profiles, material ratio curves and probability densities applied to compare the lubrication states. As a result, for the high carbon steel, the water soluble lubricant leads to better surface imprinting than the dry condition and the mineral oil. Mineral oil shows the lowest surface imprinting. For the low carbon steel, the water soluble lubricant and dry conditions lead to better surface imprinting than the mineral oil.
InP-Lattice Matched Quantum Well Solar Cells for Remote and Portable Power (2010)

In this work, we report the theoretical design and modeling of high efficiency, multijunction (MJ) solar cells lattice matched to InP. A wide range of direct bandgaps is available in this material system to enable MJ devices with high efficiency and robust performance in diverse operating environments. We provide realistic estimates of the expected conversion efficiency by quantifying the effect of non-radiative recombination via the radiative efficiency at a fixed current density. The effect of metamorphic junctions needed to achieve gaps <1.4 eV on GaAs in inverted metamorphic technology is then represented by the reduced radiative efficiency derived from state-of-the-art experimental results. We show that high efficiencies obtained by the current GaAs-based MJ technology can be accomplished without any relaxed layers on InP and derive the optimum energy gaps, the alloys, and quantum-well structures necessary to realize them. Conversion efficiencies of 37.2%, 38.9% and 52% are projected for InP-based MJ devices under AM0, AM1.5G and AM1.5D low AOD (500X) illumination. The corresponding values simulated for metamorphic cells with a single relaxed junction are 33.1%, 38.3%, and 51%.
1Deep Representations for Iris, Face, and Fingerprint Spoofing Detection (2016)

Abstract—Biometrics systems have significantly improved per-son identification and authentication, playing an important role in personal, national, and global security. However, these systems might be deceived (or “spoofed”) and, despite the recent advances in spoofing detection, current solutions often rely on domain knowledge, specific biometric reading systems, and attack types. We assume a very limited knowledge about biometric spoofing at the sensor to derive outstanding spoofing detection systems for iris, face, and fingerprint modalities based on two deep learning approaches. The first approach consists of learning suitable convolutional network architectures for each domain, while the second approach focuses on learning the weights of the network via back-propagation. We consider nine biometric spoofing benchmarks — each one containing real and fake samples of a given biometric modality and attack type — and learn deep representations for each benchmark by combining and contrasting the two learning approaches. This strategy not only provides better comprehension of how these approaches interplay, but also creates systems that exceed the best known results in eight out of the nine benchmarks. The results strongly indicate that spoofing detection systems based on convolutional networks can be robust to attacks already known and possibly adapted, with little effort, to image-based attacks that are yet to come.
Exposure to Formaldehyde: Effects on Pulmonary Function (1982)

Forty-seven subjects exposed to formaldehyde (mean air concentration 0.45 mg/m3) and 20 unexposed subjects, all of whom were employed at a carpentry shop, were studied with regard to symptoms and pulmonary function. Symptoms involving eyes and throat as well as chest oppression were significantly more common in the exposed subjects than in the unexposed controls. Spirometry and single breath nitrogen washout were normal Monday morning before exposure to formaldehyde. A reduction in forced expiratory volume in 1 sec by an average of 0.2 L (P = .002), percent forced expiratory volume by 2% (P = .04), maximum midexpiratory flow by 0.3 L/sec (P = .04) and an increase in closing volume in percentage of vital capacity by 3.4% (P - .002) were seen after a day of work and exposure to formaldehyde, suggesting bronchoconstriction. Smokers and nonsmokers displayed similar changes in spirometry and nitrogen washout.
The Effect of Structure-Borne Noise in Submarine Hull Plating on Boundary Layer Stability. (1977)

Abstract : This report deals with the potential boundary layer destabilizing action of machinery generated structure-borne noise in submarine hull plating. Boundary layer transition is assumed to be governed by the eigenvalues of the Orr-Sommerfeld equation and the structure-borne noise field is taken to be flexural in nature. The structure-borne noise field is decomposed into propagating wave fields and near-fields such as would surround foundation structures or other hull impedance discontinuities. It is found that for the frequency range generally associated with structure-borne noise, say 30 - 10 to the 4th power Hz, the propagating wave fields are not destabilizing in that they do not contain components which are coincident with the appropriate eigenvalues of the Orr-Sommerfeld equation. By contrast, the near-fields will contain components which are coincident with the potentially destabilizing, eigenvalues of the Orr-Sommerfeld equation. These near-fields are interpreted in terms of equivalent propagating fields to which they are found to be of (relatively) low level. Available experimental results are discussed in terms of the submarine environment and it is found that although transition may be affected by structure-borne noise levels less than, say, the expected free-stream turbulence levels, the measured noise levels required for destabiliziation are higher than one expects in submarine hull plating. Finally, a mechanical analogue to the Orr-Sommerfeld equation is presented in the form of a vibrating elastic plate resting on a locally reacting foundation of specific form. In the analogue Reynolds number becomes the cube of the slenderness ratio of the plate.
Constitutive and induced phosphorylation of the <i>alpha</i> - and <i>beta</i> -chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions. (1990)

We sought to determine whether the activation event which renders the CD11/CD18 leukocyte integrin/Leu-CAM glycoproteins capable of promoting cell to cell adhesion was associated with the induced posttranslational modification of phosphorylation. In neutrophils, two species of alpha-chains, a predominant CD11b 165-kDa subunit and a minor 150-kDa CD11c subunit were found to be constitutively phosphorylated. However, the 95-kDa CD18 common beta-chain was not phosphorylated in resting cells but became strongly phosphorylated in cells incubated with PMA. The beta-chain was phosphorylated in a dose-related manner within 1 min of the addition of PMA, reached maximal intensity between 4 to 10 min, and remained fully phosphorylated at 30 min. The similarities of the kinetics of homotypic aggregation induced by PMA to the time course of phosphorylation suggest that phosporylation may be relevant to at least this type of Leu-CAM-dependent adhesion. In contrast, in the presence of FMLP which induces aggregation with different kinetics than PMA, no phosphorylation of the common beta-chain was observed over a time interval of from 30 s to 10 min further emphasizing the apparent differences in the two modes of activation to an adhesive state. The phosphorylated species on neutrophils were readily detected by immunoprecipitation with each CD18 mAb and most but not all CD11b mAb which otherwise precipitated 125I-labeled CD11b species suggesting that the CD11b alpha-chain labelled with 32P may differ slightly from the 125I-labeled species in terms of its recognition by certain CD11b mAb. In mononuclear cells, similar constitutive phosphorylation of the CD11a and CD11c alpha-chains was observed that remained unchanged in the presence of either FMLP or PMA. As was demonstrated in neutrophils, phosphorylation of the CD18 beta-chains of mononuclear cells was not constitutive but was induced in the presence of PMA and not FMLP. Taken together these data suggest the existence of specific recognition sites on beta-chains for a regulatory kinase-phosphatase system.
Simultaneous Estimation of the SOC and Parameters of Batteries for HEV/EV (2016)

<div class="section abstract"><div class="htmlview paragraph">This paper proposes a battery state estimation on a battery management system (BMS) for hybrid electric vehicles (HEVs) and electric vehicles (EVs). It is important to estimate a state of charge (SOC) and parameters of the battery such as a state of health (SOH), internal resistances and dynamics of electrochemical reactions. The BMS can provide information on the driving range of the EVs to the drivers by accurately estimating SOC and SOH. It can also calculate a state of power (SOP) to use the battery safely by accurately estimated SOC, internal resistances and others. For that purpose, this paper proposes the BMS adopted a simultaneous state of charge (SOC) and parameter estimation method using log-normalized unscented Kalman filter (LnUKF). The key idea is a lognormalization of the parameters to improve numerical stability and robustness of the algorithm. The proposed system is verified by a series of simulations using experimental data with EVs. One of the SOC and parameter estimation results is for low temperature data on the chassis dynamometer. The proposed system can accurately estimate SOC and parameters of the battery without relying on the experimentally obtained data even if it is under the harsh conditions such as low temperature environment. As a result, it can accurately estimate SOH and SOP of the battery since they are estimated by using estimates of SOC and parameters of the battery.</div></div>
Effects of the orexin receptor antagonist suvorexant on respiration during sleep in healthy subjects (2015)

Suvorexant is an orexin receptor antagonist for treating insomnia. The maximum approved dose in the United States and Japan is 20 mg. We evaluated suvorexant effects on respiration during sleep in a randomized, double-blind, 3-period crossover study of healthy adult men (n = 8) and women (n = 4) ≤ 50 years old who received single-dose suvorexant 40 mg, 150 mg, and placebo. Respiration during sleep was measured by oxygen saturation (SpO2 , primary end point) and the Apnea Hypopnea Index (AHI). The study was powered to detect a reduction greater than 5% in SpO2 . There was no effect of suvorexant on mean SpO2 during sleep. The mean (90%CI) treatment differences versus placebo were -0.3 (-1.2-0.6) for 40 mg and 0.0 (-0.9-0.9) for 150 mg. There were no dose-related trends in individual SpO2 values. Mean SpO2 was >96% for all treatments during total sleep time and during both non-REM and REM sleep. There was no effect of either suvorexant dose on AHI. The mean (90%CI) treatment differences versus placebo were 0.8 (-0.7-2.3) for 40 mg and -0.2 (-1.7-1.3) for 150 mg. Suvorexant was generally well tolerated; there were no serious adverse experiences or discontinuations. These data from healthy subjects suggest that suvorexant lacks clinically important respiratory effects during sleep at doses greater than the maximum recommended dose for treating insomnia.
Surgical cut down for vascular access with conscious sedation for transcatheter aortic valve replacement: the best of both worlds? (2018)

We demonstrate that the use of conscious sedation and surgical cut down for femoral arterial access resulted in a major vascular complication rate of less than 1% and low in-hospital mortality rates without any significant increase in wound complications.
Mutational analysis of arginine 177 in the nucleotide binding site of beta-actin (2000)

Actin ADP-ribosylated at arginine 177 is unable to hydrolyze ATP, and the R177 side chain is in a position similar to that of the catalytically essential lysine 71 in heat shock cognate protein Hsc70, another member of the actin-fold family of proteins. Therefore, actin residue R177 has been implicated in the mechanism of ATP hydrolysis. This paper compares wild-type β-actin with a mutant in which R177 has been replaced by aspartic acid. The mutant β-actin was expressed in Saccharomyces cerevisiae and purified by DNase I-affinity chromatography. The mutant protein exhibited a reduced thermal stability and an increased nucleotide exchange rate, suggesting a weakened interdomain connection. The ATPase activity of G-actin and the ATPase activity expressed during polymerization were unaffected by the R177D replacement, showing that this residue is not involved in catalysis. In the presence of polymerizing salts, ATP hydrolysis by both wild-type Mg-β-actin and the mutant protein preceded filament formation. With the mutant actin, the initial rate of ATP hydrolysis was as high as with wild-type actin, but polymer formation was slower, reached lower steady-state levels, and the polymers formed exhibited much lower viscosity. The critical concentration of polymerization (Acc) of the mutant actin was increased 10-fold as compared to wild-type actin. Filaments formed from the R177D mutant β-actin bound phalloidin.
A sulfur-bridged iron(III) porphyrin-copper(II) system: relevance to cytochrome c oxidase (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA sulfur-bridged iron(III) porphyrin-copper(II) system: relevance to cytochrome c oxidaseCynthia K. Schauer, Kozo Akabori, C. Michael Elliott, and Oren P. AndersonCite this: J. Am. Chem. Soc. 1984, 106, 4, 1127–1128Publication Date (Print):February 1, 1984Publication History Published online1 May 2002Published inissue 1 February 1984https://pubs.acs.org/doi/10.1021/ja00316a058https://doi.org/10.1021/ja00316a058research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
DUAL OVER‐EXPRESSION OF IRS‐1 AND HEPATITIS B X ANTIGEN CAUSE PRE‐MALIGNANT ALTERATIONS IN LIVER (2007)

Hepatocellular carcinoma (HCC) is linked to Hepatitis B (HBV) or C virus infection, over-expression of genes that promote growth, e.g. insulin receptor substrate, type 1 (IRS1), and increased DNA damage, but the changes in gene expression that lead to dysplasia/cellular transformation in previously normal liver have not been identified. To address this question, we generated transgenic mice in which the HBV X (ATX) gene, IRS1, or both (ATX/IRS1) were over-expressed in liver. ATX/IRS1 livers had increased frequencies of hepatic dysplasia, and IRS1 and ATX/IRS1 livers had more extensive steatosis relative to other groups. All 3 transgenic groups had significantly increased IRS1, IGF-1, PCNA, and Wnt3 mRNA levels, and increased immunoreactivity for 8OHdG and HNE, indices of DNA damage and oxidative stress. The ATX/IRS mice were distinguished by having the highest levels of Wnt3 and Frizzled7, and selectively increased expression of IGF-2 and aspartyl-asparaginyl-β-hydroxylase (AAH). These results suggest that over-expression of HBV X or IRS1 can contribute to hepatocyte transformation by promoting cell turnover and DNA damage, but these effects are not sufficient to trigger an HCC cascade. However, chronic over-expression of HBV X with IRS1 is sufficient to cause hepatocellular dysplasia, suggesting that up-regulation of Wnt signaling genes, as well as AAH, a molecule that mediates cell motility and invasion, could serve as biomarkers for patients at risk for developing HCC.
Pituitary adenomas evade apoptosis via noxa deregulation in Cushing’s disease (2022)

Sporadic pituitary adenomas occur in over 10% of the population. Hormone-secreting adenomas, including those causing Cushing's disease (CD), cause severe morbidity and early mortality. Mechanistic studies of CD are hindered by a lack of in vitro models and control normal human pituitary glands. Here, we surgically annotate adenomas and adjacent normal glands in 25 of 34 patients. Using single-cell RNA sequencing (RNA-seq) analysis of 27594 cells, we identify CD adenoma transcriptomic signatures compared with adjacent normal cells, with validation by bulk RNA-seq, DNA methylation, qRT-PCR, and immunohistochemistry. CD adenoma cells include a subpopulation of proliferating, terminally differentiated corticotrophs. In CD adenomas, we find recurrent promoter hypomethylation and transcriptional upregulation of PMAIP1 (encoding pro-apoptotic BH3-only bcl-2 protein noxa) but paradoxical noxa downregulation. Using primary CD adenoma cell cultures and a corticotroph-enriched mouse cell line, we find that selective proteasomal inhibition with bortezomib stabilizes noxa and induces apoptosis, indicating its utility as an anti-tumor agent.
Dietary fibre content and cell wall polysaccharides in prunes (2007)

Les teneurs en fibres alimentaires des pruneaux ont t mesures par la mthode de l'AOAC (Association of Official Analytical Chemists) qui permet de quantifier les fibres solubles, les fibres insolubles et les fibres totales (somme des solubles et des insolubles). Les pruneaux sont riches en fibres puisque leur teneur est de 6-7% par rapport la matire frache ; les fibres solubles reprsentent environ 57% et les insolubles 43%. Les fibres solubles sont particulirement riches en substances pectiques alors que les fibres insolubles contiennent principalement de la cellulose avec des quantits significatives de pectines et d'hmicelluloses.
High-mobility group box protein 1 promotes the survival of myeloid-derived suppressor cells by inducing autophagy (2016)

Myeloid-derived suppressor cells are immune-suppressive cells that are elevated in most individuals with cancer, where their accumulation and suppressive activity are driven by inflammation. As myeloid-derived suppressor cells inhibit anti-tumor immunity and promote tumor progression, we are determining how their viability is regulated. Previous studies have established that the damage-associated molecular pattern molecule high-mobility group box protein 1 drives myeloid-derived suppressor cell accumulation and suppressive potency and is ubiquitously present in the tumor microenvironment. As high-mobility group box protein 1 also facilitates tumor cell survival by inducing autophagy, we sought to determine if high-mobility group box protein 1 regulates myeloid-derived suppressor cell survival through induction of autophagy. Inhibition of autophagy increased the quantity of apoptotic myeloid-derived suppressor cells, demonstrating that autophagy extends the survival and increases the viability of myeloid-derived suppressor cells. Inhibition of high-mobility group box protein 1 similarly increased the level of apoptotic myeloid-derived suppressor cells and reduced myeloid-derived suppressor cell autophagy, demonstrating that in addition to inducing the accumulation of myeloid-derived suppressor cells, high-mobility group box protein 1 sustains myeloid-derived suppressor cell viability. Circulating myeloid-derived suppressor cells have a default autophagic phenotype, and tumor-infiltrating myeloid-derived suppressor cells are more autophagic, consistent with the concept that inflammatory and hypoxic conditions within the microenvironment of solid tumors contribute to tumor progression by enhancing immune-suppressive myeloid-derived suppressor cells. Overall, these results demonstrate that in addition to previously recognized protumor effects, high-mobility group box protein 1 contributes to tumor progression by increasing myeloid-derived suppressor cell viability by driving them into a proautophagic state.
Performance of bit metric derivation method using CCI signals for OFDM adaptive array antenna (2009)

This paper proposes a bit metric derivation method for OFDM adaptive array in combination with channel coding. In the proposed approach, post-FFT processing is adopted as an OFDM adaptive array architecture and the bit metric required for channel coding is derived considering the effect of the residual CCI signals in the array output of each sub-channel. The transmission performance is evaluated in the presence of severe CCI channels by means of the computer simulations and the effectiveness of the proposed approach is demonstrated compared with the traditional bit metric method.
Dative Bonds in Main‐Group Compounds: A Case for Fewer Arrows! (2013)

Risky business? The use of dative bonds to describe the electronic structure of main-group compounds has come into vogue in recent years. But where are the limits? When does the description as a dative bond make sense and when is this view misleading? This Essay develops the idea on the basis of current examples.