gebhart/patrepeval huggingface dataset:
Acute respiratory disease in University of the Philippines and University of Wisconsin students. A comparative study. (1967)

In a comparison of acute respiratory disease patterns and incidence in students in a semi-tropical climate at the University of the Philippines with those in students in a temperate climate at the University of Wisconsin, USA, it was found that, while respiratory infections were the commonest cause of infirmary admissions in both institutions, yet, contrary to expectations, their incidence and relative importance were actually greater in the Philippine students than in the Wisconsin students. Peak rates occurred during the rainy season in the Philippines and during the coldest months in Wisconsin. Acute infectious mononucleosis was absent in the Philippines and streptococcal sore throat and primary atypical pneumonia were rare, but the three conditions were common in Wisconsin. The authors suggest that this difference in clinical pattern may be due to immunity in the Philippines students as a result of prior childhood infection.
Uterine Artery Embolization for Leiomyomas: Pre- and Postprocedural Evaluation with US (2005)

Transabdominal and transvaginal ultrasonography (US) are commonly used to assess the uterus and pelvis prior to and following uterine artery embolization (UAE) for symptomatic leiomyomas (fibroids). Preprocedural US may help identify relative contraindications for UAE, whereas postprocedural US can help determine the quality and quantity of fibroid involution and help identify any complications associated with the procedure. The consulting radiologist should be familiar with certain typical postprocedural US findings, which might otherwise be improperly interpreted, leading to unnecessary intervention. Magnetic resonance (MR) imaging or computed tomography will frequently provide the most accurate information in UAE patients with certain pathologic conditions, and early study results suggest that MR imaging may be helpful in predicting treatment response. Nevertheless, US is a readily available first-line imaging modality and a well-accepted method for both pre- and postprocedural evaluation of patients who undergo UAE. A proper understanding of the US findings in this patient population allows objective determination of treatment response and detection of most of the commonly recognized complications that are associated with UAE.
On the Number of Steroid‐Binding Sites of Δ<sup>5</sup>‐3‐Oxosteroid Isomerase (1980)

The number of steroid-binding sites in delta 5-3-oxosteroid isomerase of Pseudomonas testosteroni (EC 5.3.3.1) has been determined from measurements of the red shift of the ultraviolet chromophore of 19-nortestosterone upon binding to the enzyme. The experiments include spectroscopic measurements when limiting concentrations of either 19-nortestosterone or isomerase are titrated with varying concentrations of the complementary ligand. Analysis of the results indicates one binding site per subunit (Mr 13 394). Scatchard plots indicate a single family of equivalent binding sites. 5, 10-Secoestr-5-yne-3, 10, 17-trione is a suicide substrate of isomerase [Batzold & Robinson (1975) J. Am. Chem. Soc. 97, 2576]. The time course for inactivation of isomerase with an excess of 5, 10-seco[7-3H]estr-5-yne-3, 10, 17-trione was parallel to the covalent incorporation of steroid and gave a final stoichiometry of nearly one steroid molecule per subunit of enzyme. Alkylation of [14C] isomerase with excess of this 3H-labeled steroid followed by gel-filtration and dialysis gave an inactivated enzyme with a 3H/14C ratio that corresponds to one molecule of steroid bound per subunit; this stoichiometry was constant over a wide range of protein concentrations (0.1--10 mg/ml). Diffusion of [3H]progesterone into hexagonal crystals of isomerase showed that at saturation one steroid molecule was bound per protomer. Taken together these findings strongly support the conclusion that one molecule of steroid is bound per subunit of isomerase both in solution and in the crystal state.
A calcium chloride solution, dry-ice, low temperature bath (1970)

Investigates the characteristics of a calcium chloride solution, dry-ice, low temperature bath.
HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus (2003)

Our objective was to determine the HLA-DPB1 allele associations of anticardiolipin (aCL) and anti-beta2GPI (a(beta)2GPI) antibodies, and of clinical manifestations of the antiphospholipid syndrome (APS), in systemic lupus erythematosus (SLE). We studied 577 European patients with SLE. aCL and a(beta)2GPI antibodies were measured by ELISA. Molecular typing of HLA-DPB1 locus was performed by polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. aCL showed positive association with -DPB1*1501 (P = 0.005, OR = 7.4), and -DPB1*2301 (P = 0.009, OR = 3.3). a(beta)2GPI showed positive association with -DPB1*0301 (P = 0.01, OR = 1.9), and -DPB1*1901 (P = 0.004, OR = 8.1). In addition, livedo reticularis was associated with -DPB1*1401, and Raynaud's phenomenon with -DPB1*2001. In conclusion, HLA-DPB1 locus may contribute to the genetic predisposition to develop antiphospholipid antibodies and clinical manifestations of the APS in patients with SLE.
LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity (2018)

Excess lipid accumulation is an early signature of nonalcoholic fatty liver disease (NAFLD). Although liver receptor homolog 1 (LRH-1) (encoded by NR5A2) is suppressed in human NAFLD, evidence linking this phospholipid-bound nuclear receptor to hepatic lipid metabolism is lacking. Here, we report an essential role for LRH-1 in hepatic lipid storage and phospholipid composition based on an acute hepatic KO of LRH-1 in adult mice (LRH-1AAV8-Cre mice). Indeed, LRH-1-deficient hepatocytes exhibited large cytosolic lipid droplets and increased triglycerides (TGs). LRH-1-deficient mice fed high-fat diet displayed macrovesicular steatosis, liver injury, and glucose intolerance, all of which were reversed or improved by expressing wild-type human LRH-1. While hepatic lipid synthesis decreased and lipid export remained unchanged in mutants, elevated circulating free fatty acid helped explain the lipid imbalance in LRH-1AAV8-Cre mice. Lipidomic and genomic analyses revealed that loss of LRH-1 disrupts hepatic phospholipid composition, leading to lowered arachidonoyl (AA) phospholipids due to repression of Elovl5 and Fads2, two critical genes in AA biosynthesis. Our findings reveal a role for the phospholipid sensor LRH-1 in maintaining adequate pools of hepatic AA phospholipids, further supporting the idea that phospholipid diversity is an important contributor to healthy hepatic lipid storage.
Living cationic polymerization of vinyl ethers with carboxylic acid/tin tetrahalide initiating systems. III. Benzoic acid and related weakly acidic carboxylic acids for the living polymerization of isobutyl vinyl ether (2000)

The cationic polymerization of isobutyl vinyl ether with weakly acidic benzoic acids (1 and 4) and related carboxylic acids (3 and 5) in conjunction with SnBr4 led to living polymers with narrow molecular weight distributions (MWDs). The steric effects of the phenyl group directly connected to the carbonyl group in the carboxylate counteranion on the living nature and the polymer MWDs are discussed.
Mass spectrometric identification of the <i>N</i> ‐monosubstituted <i>N</i> ‐hydroxylamino functionality in protonated analytes via ion/molecule reactions in tandem mass spectrometry (2015)

A method based on functional group-selective ion/molecule reactions in a linear quadrupole ion trap mass spectrometer has been demonstrated to allow the identification of protonated compounds with the N-monosubstituted hydroxylamino functionality. Only N-monosubstituted hydroxylamines react with MOP via formation of an adduct that has eliminated methanol.
Winter irrigation increased yield of ‘Washington’ navel orange (<i>Citrus sinensis</i>L. Osbeck) (1996)

SummaryThe present study aimed to quantify the effect of withholding irrigation during the winter season in southern California on the productivity of ‘Washington’ navel orange and to determine whether the additional expense of irrigating navel orange trees during the winter is a cost-effective production management strategy. Yield and fruit size were quantified for 30 year old ‘Washington’ navel orange scions on Troyer citrange rootstock which were rain-fed from October 1 to March 1 in each of three successive years and for another set of trees which were irrigated during the winter. Supplementing winter rainfall with irrigation significantly increased the weight of fruit per tree in all three years of the study (45 ± 17 kg fruit tree−1, n = 3 years) and number of fruit per tree in the two years in which the rain-fed, –winter irrigation trees had significantly lower predawn water potentials than the +winter irrigation trees. Despite the yield increases which resulted from supplementing winter rain with irrigation in each year of the study, there was no reduction in the number of commercially valuable fruit with tranverse diameters between 7.0 to 8.0 cm in any year (P≤0.05). Trees receiving winter irrigation to supplement rainfall were less affected by a preharvest freeze: compare a 50% reduction in yield from the previous year for the –winter irrigation treatment to a 93% reduction for the –winter irrigation trees. Irrigation treatment did not affect tree nitrogen status. Even in the year when the lowest net increase in yield was obtained with the greatest amount of irrigation water, valued at a high cost for California, winter irrigation was a cost-effective management strategy for the production of ‘Washington’ navel orange.
ONE-STAGE REVISION SURGERY FOR INFECTED MEGAPROSTHESES (1997)

We have reviewed the results of one-stage revision surgery in 18 patients for infection of megaprostheses implanted after the resection of malignant bone and soft-tissue tumours. At a mean follow-up of 52.0 ± 35.0 months (18 to 135) infection was eliminated in 14 of the 18 patients. The infection-free patients showed no abnormal tests for inflammation and had a mean Enneking score of 20.6 ± 5.0 points (maximum 30 points). We suggest that one-stage revision without exchange of the anchorage parts is justified in patients with megaprostheses infected by antibiotic-sensitive micro-organisms.
Assessment of the Multi-mycotoxin-Binding Efficacy of a Carbon/Aluminosilicate-Based Product in an in Vitro Gastrointestinal Model (2007)

A laboratory model, set to simulate the in vivo conditions of the porcine gastrointestinal tract, was used to study the small intestinal absorption of several mycotoxins and the effectiveness of Standard Q/FIS (a carbon/aluminosilicate-based product) in reducing mycotoxin absorption when added to multitoxin-contaminated diets. Mycotoxins were quickly absorbed in the proximal part of the small intestine at levels of 105 and 89% for fumonisins B1 and B2, respectively, 87% for ochratoxin A, 74% for deoxynivalenol, 44% for aflatoxin B1, and 25% for zearalenone. Addition of Standard Q/FIS to the diet (up to 2%, w/w) significantly reduced mycotoxin absorption, in a dose-dependent manner, up to 88% for aflatoxin B1, 44% for zearalenone, and 29% for the fumonisins and ochratoxin. Standard Q/FIS was ineffective in reducing deoxynivalenol uptake. These findings suggest that Standard Q/FIS can be used as a multitoxin adsorbent material to prevent the individual and combined adverse effects of mycotoxins in animals.
Säureamid‐Reaktionen, XXX. Synthesen von Pyrazolo)[3.4‐<i>d</i>]pyrimidinen (1962)

Abstract Es wird eine einfache synthese von 3‐Hydroxy‐pyrazolo[3.4‐ d ]pyrimidinen durch Erhitzen von 3‐Amino‐pyrazolonen‐(5) mit Trisformaminomethan bzw. Formamid beschrieben. Aus den 2‐Alkyl‐ oder 2‐Phenyl‐3‐amino‐pyrazolonen‐(5) entstehen je nach den Reaktionsbedingungen neben den Pyrazolo‐pyrimidinen auch Pyrazolylmethylen‐pyrazolonimide.
Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study (2021)

The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed to compare patients who underwent SLNB vs. observation. A multivariate Cox regression was used. A total of 1438 patients were matched by propensity score. There were no significant differences in melanoma-specific survival (MSS) between the SLNB and observation groups. Predictors of MSS in the multivariate model were age, tumor thickness, ulceration, and interferon treatment. Results were similar for disease-free survival and overall survival. The 5- and 10-year MSS rates for SLN-negative and -positive patients were 98.5% vs. 77.3% (<i>p</i> < 0.001) and 97.3% vs. 68.7% (<i>p</i> < 0.001), respectively. SLNB does not improve MSS in patients with thin melanoma. It also had no impact on DSF or OS. However, a considerable difference in MSS, DFS, and OS between SLN-positive and -negative patients exists, confirming its value as a prognostic procedure and therefore we recommend discussing the option of SLNB with patients.
Bevacizumab treatment of symptomatic pseudoprogression after boron neutron capture therapy for recurrent malignant gliomas. Report of 2 cases (2013)

Bevacizumab showed marked effects on symptomatic pseudoprogression after BNCT. BNCT combined with bevacizumab may prolong the survival of patients with recurrent malignant gliomas.
Evaluation of Sampling Methods in Constructing Response Surface Approximations (2006)

Response surface approximations (RSA) are often used as inexpensive replacements for computationally expensive computer simulations. Once a RSA has been computed, it is cheap to evaluate this “meta-model” or surrogate, and thus the RSA is often used in a variety of contexts, including optimization and uncertainty quantification. Usually, some method of sampling points over the input domain is used to generate samples of the input variables. These samples are run through the computer simulation. A response surface approximation is then generated based on the sample points. This report presents a study investigating the dependency of the response surface method on the sampling type. The purpose of this study was to address the question: Does a particular RSA type perform better (in terms of a better fit) if a particular sampling method is used? The RSA types examined were kriging, polynomial regression, and multivariate adaptive regression splines (MARS). The sampling types examined were Latin Hypercube, Halton, Hammersley, Centroidal Voronoi Tesselation (CVT), and standard Monte Carlo sampling. The example problems were a 5-dimensional version of Rosenbrock’s function and the Paviani function. RSA of the three response surface types were developed based on the five sampling methods. Performance was compared using ANOVA techniques.
In‐situ‐Bildung von (BN)<sub>2</sub>‐Pyrenen und elektrolumineszierenden Elementen im Festkörper (2015)

Abstract Neuartige BN‐heterocyclische Verbindungen reagieren in einer doppelten Aren‐Photoeliminierung unter Bildung gelb fluoreszierender BN‐Pyrene mit zwei B‐N‐Einheiten. Bemerkenswert hierbei ist, dass die doppelte Aren‐Eliminierung auch durch elektrisch erzeugte Exzitonen in elektrolumineszierenden (EL) Bauelementen gesteuert werden kann. Dies ermöglicht die In‐situ‐Umwandlung von BN‐Heterocyclen in BN‐Pyrene im Festkörper und damit die Verwendung von BN‐Pyrenen als Emitter in EL‐Bauelementen. Dieses Phänomen der exzitongesteuerten Eliminierung (EDE) in situ wurde auch für weitere BN‐Heterocylen beobachtet.
Green electroluminescence in crystals of ZnS0.6Se0.4 (1974)

Green-light-emitting devices with electrode areas of 1 mm2 have been prepared on crystals of a solid solution of zinc sulfide and selenide with the composition ZnS0.6Se0.4. A luminance of 200 fL was achieved at a bias of 11 V which corresponds to a power efficiency of 0.06%. The emission at room temperature was contained in a braod band with a maximum at 5450 Å (2.27 eV). Preliminary trials with a crystal of zinc sulfide produced a blue (4800 Å, 2.58 eV) emission with a luminance of 90 fL from an area of 1 mm2 for a power dissipation of 600 mW at a bias of 20 V.
Endocrine and Metabolic Actions of Ghrelin (2009)

The neuroendocrine system plays a pivotal role in the control of growth, puberty, reproduction, and intermediate metabolism. The last decades have witnessed rapid progress in the understanding of the molecular and biochemical mechanisms involved in neuroendocrine function, paralleled by dramatic improvements in imaging techniques. In this volume an international group of basic and clinical investigators presents their latest research on neuroendocrine physiology, advances in the control of the onset of puberty and its disorders, and basic and clinical aspects of the GH/IGF-1 and hypothalamic-pituitary-adrenal axes. An entire section is dedicated to pituitary tumors, including genetics and neuroimaging, and another covers the neuroendocrine control of substrate metabolism, including hypothalamic obesity and anorexia. Pragmatic and topical, this book is a must read for pediatricians, endocrinologists and clinical researchers working in the field of pediatric neuroendocrinology.
Effect of early weaning and concentrate supplementation at forage intake and ingestive behavior of sheep grazing Tifton 85 (Cynodon spp.) (2012)

The objective of this study was to evaluate then early weaning and concentrate supplementation effect at pasture characteristics, forage intake and ingestive behavior of lambs grazing Tifton 85 (Cynodon spp.). A randomized block design was used with four treatments, three replications and five lambs per replicate. A total of 60 Suffolk lambs, that 36 were females and 24 steers. The treatments had corresponded to the combinations between early weaning precocious and concentrate supplementation strategies, that resulted in the following ones finishing systems: 1) lambs kept with mothers without supplementation; 2) lambs kept with mothers supplemented with concentrate in creep feeding at 2% of body weigh (BW) in DM/day; 3) weaned lambs at 45 ± 5 days without supplementation and 4) weaned lambs at 45 ± 5 days and supplemented with concentrate at 2% of BW in DM/day. Grazing utilization method was continuous stocking with adjustment every 21 days, to maintain forage offer at 12% of BW in DM/day. To characterize the pastoral environment was assessed: morphological composition of pasture. There were made four observations the behavioral activities for individually lambs per 24 hours, such as: grazing, ruminating, suckling, supplementation, and others activities. The intake rate was measured using the technique of double sampling and determination of bite rate was made by visual observation of the number of bits made for animal. The behavior and the distribution of daily activities made by the lambs are influenced for the strategies evaluated. The exclusive presence of milk or supplement concentrate in the diet are important modulators of grazing activity, and the absence of these nutrient sources were offset per an increase in grazing time. This response considered the decrease in nutritional support and lower efficiency in harvesting the forage by lambs. The weaning influenced the morphological characteristics of the pasture, which showed favored the grazing by lamb when their mother was present. The results obtained in the evaluation of forage intake indicated that weaning was affected by the variables that describe the grazing process, except for bite mass and intake speed. We conclude that the finishing of early weaned lambs at grazing causes changes at pasture characteristics, which may limit forage intake. The concentrate supplementation does not affect the variables that describe the process of grazing lambs on pastures.
Average iterations of accessible nonlinear witnesses (2014)

We present a construction of accessible nonlinear witnesses in terms of an averaged iteration. These witnesses will always detect more states than their linear counterparts. We also review sufficient conditions so that their values can be computed from the same experimental data as their linear counterparts. Finally, we prove that these nonlinear witnesses detect an extensive set of states whose entanglement is detected by the partial transposition criteria.
Exercise-induced vasodilation in healthy males: A marker of reduced endothelial function (2015)

The difference in the vasodilatory response before and after exercise, as assessed by non-invasive methodology, is related to endothelial and inflammatory biomarkers in healthy males.
Thermo-Viscoelastic Analysis of Warp Deformation and Residual Stress for Laminated Bodies of Flip-Chip Mounted LSI Device. (1997)

工業的に興味のあるCOG (Chip On Glass) 実装形態を想定して, LSIチップ/接着剤/ガラス基板からなる単純化三層積層体を取りあげ, これを空気冷却した場合の冷却過程で生じる反り変形挙動, ならびに冷却後の残留応力を熱粘弾性数値解析と計測実験から求めた。その結果, 積層体の反り変形量を定量化するとともに, 冷却途中での反り変形挙動は構成材料の組み合わせに大きく左右され, 反り変形を抑制するための適正な層構成が存在することがわかった。次いで, 残留反り変形量は熱粘弾性挙動を示す接着剤の厚さに大きく依存し, 残留応力も積層体全体の剛性と構成材料の熱収縮力との力の均衡によって決定されることを明らかにした。これにより, 有機材料系複合基板の熱荷重によって生じる反り変形を抑制するための, 材料・層構成に関する最適設計指針を得ることが可能となった。
The effect of plasma upon lymphocyte response in vitro. Demonstration of a humoral inhibitor in patients with sarcoidosis. (1974)

The role of humoral inhibitors of lymphocyte functions was evaluated in subjects with sarcoidosis. A reproducible system was developed to evaluate the capacity of human plasma samples to support lymphocyte responses in vitro to PHA and to Candida albicans antigen. There was an unacceptable ten-fold variation in lymphocyte response to PHA among cultures that contained different individual samples of normal plasma. However, when any three normal plasma samples were pooled, the variation was reduced to two-fold. Seven out of twenty-five individual normal plasma samples tested did not support stimulation as well as a pool of plasma. In contrast, autologous plasma sustained normal lymphocyte stimulation as well as or better than pooled homologous plasma. We tested the ability of plasma from subjects with sarcoidosis to support the stimulation of autologous lymphocytes by PHA and antigen, and compared this response to that obtained when the same lymphocytes were stimulated in cultures that contained pooled normal plasma. Lymphocytes of thirteen out of twenty-six subjects with sarcoidosis did not respond to in vitro stimulation in their own plasma as well as they did when cultured in the pooled plasma of normal subjects. Plasma of fourteen out of twenty-five patients with sarcoidosis caused a significant decrease in the response of normal lymphocytes to PHA, even when added to optimal concentration of pooled normal plasma. We conclude that the plasma of patients with sarcoidosis contains an inhibitor of lymphocyte stimulation.