gebhart/patrepeval huggingface dataset:
<i>Mycoplasma genitalium</i>Infection and Female Reproductive Tract Disease: A Meta-analysis (2015)

To determine the association between Mycoplasma genitalium infection and female reproductive tract syndromes through meta-analysis, English-language, peer-reviewed studies were identified via PubMed, Embase, Biosis, Cochrane Library, and reference review. Two reviewers independently extracted data. Random-effects models were employed to calculate summary estimates, between-study heterogeneity was evaluated using I(2) statistics, publication bias was assessed via funnel plots and the Begg and Egger tests, and methodologic quality was rated. Mycoplasma genitalium infection was significantly associated with increased risk of cervicitis (pooled odds ratio [OR], 1.66 [95% confidence interval {CI}, 1.35-2.04]), pelvic inflammatory disease (pooled OR, 2.14 [95% CI, 1.31-3.49]), preterm birth (pooled OR, 1.89 [95% CI, 1.25-2.85]), and spontaneous abortion (pooled OR, 1.82 [95% CI, 1.10-3.03]). Risk of infertility was similarly elevated (pooled OR, 2.43 [95% CI, .93-6.34]). In subanalyses accounting for coinfections, all associations were stronger and statistically significant. Testing of high-risk symptomatic women for M. genitalium may be warranted.
Hematopoietic growth factors in autologous bone marrow transplantation. (1993)

The availability of recombinant human hematopoietic growth factors (rhHGFs) for clinical use has the potential to significantly decrease the morbidity and cost of autologous bone marrow transplantation (ABMT) and to make this therapeutic modality available to a broader patient population. Three rhHGFs currently have Food and Drug Administration-approved indications, although only one has a specific indication for ABMT. Recombinant human granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor have been used in several trials of ABMT. Recombinant human erythropoietin is less well studied to date in the setting of ABMT. Several investigational rhHGFs, including interleukin-3, -6, and -11, PIXY 321 (a granulocyte-macrophage colony-stimulating factor/interleukin-3 hybrid), and kit ligand (also known as "stem cell factor"), have the potential for affecting multiple lineages.
Performance evaluation of the Trans-PET<sup>®</sup>BioCaliburn<sup>®</sup>LH system: a large FOV small-animal PET system (2014)

the Trans-PET(®) BioCaliburn(®) LH system offers high spatial resolution, a large transaixal FOV and adequate sensitivity. It produces animal images of good quality and supports dynamic imaging. The system is an attractive imaging technology for preclinical research.
Inhibition of Subjective and Physiological Sexual Arousal in Women by Clonidine (1997)

Clonidine can significantly inhibit subjective and physiological sexual arousal in women. These findings have implications for deriving an etiological theory of sexual function in women and for understanding the effects of psychotherapeutic drugs on female sexual function.
Population pharmacokinetics of total and unbound plasma cisplatin in adult patients (2004)

The results support the conventional dose adjustment of cisplatin based on BSA. They also support the need for a dose reduction in case of renal insufficiency.
Dielectric studies of liquid crystals under high pressure: Static permittivity and dielectric relaxation in the nematic phase of pentylcyanobiphenyl (5CB) (1992)

Dielectric studies of a thermotropic-liquid-crystalline substance [pentylcyanobiphenyl (5CB)] under high pressure are reported. Measurements of a complex dielectric permittivity were carried out in the pressure range 0.1--160 MPa, the frequency range 1 kHz--13 MHz, and the temperature range 287--343 K. Static permittivities measured at constant pressures are governed by the [2S(T)+1]/T factor. An increase in permittivity with pressure at a constant temperature is interpreted as a result of an increasing molecular ordering and of a breaking of the dipole-dipole correlations between neighboring molecules. The relaxation time ${\mathrm{\ensuremath{\tau}}}_{\mathrm{\ensuremath{\parallel}}}$ characterizing molecular rotations around the short axes in the nematic phase is analyzed as a function of temperature and pressure, yielding an activation enthalpy of approximately 60 kJ ${\mathrm{mol}}^{\mathrm{\ensuremath{-}}1}$, which decreases with increasing pressure, and an activation volume of about 60 ${\mathrm{cm}}^{3}$ ${\mathrm{mol}}^{\mathrm{\ensuremath{-}}1}$, decreasing with increasing temperature. An activation energy in isochoric conditions was evaluated to be 37 kJ ${\mathrm{mol}}^{\mathrm{\ensuremath{-}}1}$ at ${\mathit{V}}_{\mathit{m}}$=247 ${\mathrm{cm}}^{3}$ ${\mathrm{mol}}^{\mathrm{\ensuremath{-}}1}$, 25 kJ ${\mathrm{mol}}^{\mathrm{\ensuremath{-}}1}$ at 243 ${\mathrm{cm}}^{3}$ ${\mathrm{mol}}^{\mathrm{\ensuremath{-}}1}$. A relation between the different activation parameters is discussed.
Conclusion (2000)

Abstract This chapter summarizes the preceding discussions. This book explores madness and society in Scotland during the 18th century. It presents several methodologies in order to know the perceptions of the Scottish on insanity on a day-to-day basis. It assumes that the way mental incapacity is perceived is influenced by society and culture, and therefore reflects their meanings.
Singapore. <i>La minorité musulmane de Singapour</i>. By LAURENT METZGER. Paris: L'Harmattan, 2003. Pp 296. Notes, Bibliography, Index. (2005)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Injection Mechanism and Recombination Kinetics in Electroluminescent CdTe Diodes (1966)

Diffused p—n junctions in CdTe have been shown to emit efficient electroluminescence under forward bias at 77°K. Capacitance measurements, current—voltage characteristics, photovoltaic measurements, and the shift of the emitted photon energies with current and temperature are consistent with a space-charge recombination controlled current. The dependence of the quantum efficiency on temperature and current is consistent with a simple, Schön—Klasens-type model of thermal quenching and with limitations imposed by the second law of thermodynamics. The low average concentration of majority carriers at the junction (∼1016 cm−3) that characterizes these devices is a major limitation in obtaining high efficiencies of electroluminescence at 300°K, even at high current densities.
Immunoelectron microscopic examination of Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus-infected Lymantria dispar cells: time course and localization of major polyhedron-associated proteins (1991)

Immunoelectron microscopy was employed to examine the temporal expression and localization of two proteins involved in baculovirus polyhedron assembly (polyhedrin and p10) of Orgyia pseudotsugata multicapsid nuclear polyhedrosis virus (OpMNPV) in infected Lymantria dispar cells. In addition, the association of p10 with the polyhedron envelope (PE) protein was studied. The major capsid protein (p39) was also examined to investigate the association of virion structural proteins with polyhedron formation. In infected cells, p39 did not show a concentrated association with any infected-cell structures other than nucleocapsids and appeared to be randomly distributed over the nucleocapsid surface. Likewise, polyhedrin showed no major concentrations outside of developing or mature polyhedra. The p10 antibody cross-reacted with a protein associated with condensed chromosomes in uninfected cells. In infected cells, p10 is a component of the body of fibrillar structures. The PE protein has been shown to accumulate around the periphery of fibrillar structures. Cells infected with a polyhedrin-minus virus expressing the beta-galactosidase gene under the control of the polyhedrin promoter were examined to determine whether the lack of polyhedra would influence the localization of major polyhedron-associated viral proteins. High concentrations of PE protein accumulating on the periphery of fibrillar structures appeared to be the major difference from wild-type virus-infected cells. The beta-galactosidase protein appeared to be distributed throughout the nucleus and cytoplasm, in contrast with the specific localization of the viral proteins.
Interleukin 13– and Interleukin 17A–Induced Pulmonary Hypertension Phenotype Due to Inhalation of Antigen and Fine Particles from Air Pollution (2014)

Pulmonary hypertension has a marked detrimental effect on quality of life and life expectancy. In a mouse model of antigen-induced pulmonary arterial remodeling, we have recently shown that coexposure to urban ambient particulate matter (PM) significantly increased the thickening of the pulmonary arteries and also resulted in significantly increased right ventricular systolic pressures. Here we interrogate the mechanism and show that combined neutralization of interleukin 13 (IL-13) and IL-17A significantly ameliorated the increase in right ventricular systolic pressure, the circumferential muscularization of pulmonary arteries, and the molecular change in the right ventricle. Surprisingly, our data revealed a protective role of IL-17A for the antigen- and PM-induced severe thickening of pulmonary arteries. This protection was due to the inhibition of the effects of IL-13, which drove this response, and the expression of metalloelastase and resistin-like molecule α. However, the latter was redundant for the arterial thickening response. Anti-IL-13 exacerbated airway neutrophilia, which was due to a resulting excess effect of IL-17A, confirming concurrent cross inhibition of IL-13- and IL-17A-dependent responses in the lungs of animals exposed to antigen and PM. Our experiments also identified IL-13/IL-17A-independent molecular reprogramming in the lungs induced by exposure to antigen and PM, which indicates a risk for arterial remodeling and protection from arterial constriction. Our study points to IL-13- and IL-17A-coinduced inflammation as a new template for biomarkers and therapeutic targeting for the management of immune response-induced pulmonary hypertension.
Replication pattern of the p53 and 21q22 loci in the premalignant and malignant stages of carcinoma of the cervix. (1998)

The authors believe these results reflect impairment of the replication control of homologous loci and that this phenomenon may be correlated to the phenotype of the tumor.
Carta ao leitor e ao Corpo Editorial (2013)

<em>A importância de um periódico se deve, entre outros aspectos quantitativos ou qualitativos, ao seu foco temático e à sua política editorial porque são determinantes da escolha do leitor em suas preferências e necessidades para o avanço em sua área de atuação acadêmica. Nesse sentido, um periódico de extensão universitária não é comum entre os demais periódicos; é mais especializado em seu foco e mais abrangente em sua política editorial tendo em vista as várias áreas temáticas da extensão universitária. Esta é, sem dúvida, uma tarefa que exige muito esforço e dedicação de um corpo editorial que precisa manter contato constante com seu público leitor para obter a sintonia em diversas áreas temáticas.</em> <em> </em> <em> Estas ponderações que inicialmente realizo se deve ao fato de estar nesta Pró-Reitoria de Extensão Universitária (PROEX) e ter o privilégio de cuidar junto com o Corpo Editorial da Revista Ciência e Extensão. Trata-se de um periódico eletrônico com trajetória de dez anos que sempre buscou a excelência como meta e que conta com a colaboração de equipe editorial, revisores e comissão científica composta de pesquisadores da UNESP e de várias outras instituições brasileiras e estrangeiras.</em> <em> </em> <em>Para além do fato de ter um compromisso de trabalho e dedicação à Revista Ciência e Extensão, seu Corpo Editorial tem metas de avanço rumo à excelência e ao reconhecimento do mérito que inclui a submissão ao corpo de periódicos da UNESP e depois ao Scielo. Nesse planejamento, a PROEX está comprometida e apóia integralmente as metas que visam à valorização da extensão mediante avaliação contínua, aprimoramento e reconhecimento de mérito.</em> <em> </em> <em> </em> <em> </em> <em> </em> <strong>Mariângela Spotti Lopes Fujita</strong> <strong>Pró-Reitora de Extensão Universitária da UNESP</strong>
High-grade C-reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritis. (2005)

Patients with rheumatoid arthritis (RA) are at greater risk of developing cardiovascular events compared with individuals without RA. Increased risk for cardiovascular disease in these patients is a consequence of atherosclerosis. Case-control studies have shown that increased intima-media thickness (IMT) of the common carotid artery is an indicator of generalized atherosclerosis. Some investigators have suggested that the development of atherosclerosis in RA may be related to the magnitude and chronicity of the systemic inflammation. We examined the relationship between carotid IMT to C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), which are the most commonly assessed markers of inflammatory response in patients with RA.Retrospective review of CRP and ESR values in 47 patients with longterm actively treated (at least 5 years) RA without clinically evident atherosclerosis or its complications, who had been studied for carotid IMT with high resolution B-mode ultrasound.No correlation between ESR and carotid IMT was observed. However, a correlation was found between the maximum CRP values and the carotid IMT (p = 0.009). The distribution of patients in 4 quartiles according to the average CRP values showed significant differences in the carotid IMT (p = 0.03). Those exhibiting the highest mean CRP values (quartile 4) had greater carotid IMT. There was no correlation between CRP at the time of disease diagnosis or at the time of the ultrasound study and the carotid IMT.Our study confirms that the magnitude and chronicity of the inflammatory response measured by CRP correlates directly with the presence of atherosclerosis in patients with RA.
Brain plasticity and behaviour in the developing brain. (2011)

The development of the brain reflects more than the simple unfolding of a genetic blueprint but rather reflects a complex dance of genetic and experiential factors that shape the emerging brain. Understanding the dance provides insight into both normal and abnormal development.
Attack Patterns as a Knowledge Resource for Building Secure Software (2007)

Preconception TSH was associated with preterm delivery, LGA, and LBW. Preconception TSH had a bidirectional effect on LGA, indicating a potential mechanism regarding influence of TSH on birth weight. TSH within 0.91 to 1.82 mIU/L was the potential safe range for preconception women.
Tissue Kallikrein Alleviates Cerebral Ischemia‐Reperfusion Injury by Activating the B2R‐ERK1/2‐CREB‐Bcl‐2 Signaling Pathway in Diabetic Rats (2016)

Diabetes mellitus (DM) substantially increases the risk of ischemic stroke and reduces the tolerance to ischemic insults. Tissue kallikrein (TK) has been demonstrated to protect neurons from ischemia/reperfusion (I/R) injury in orthoglycemic model by activating the bradykinin B2 receptor (B2R). Considering the differential effects of B2R or bradykinin B1 receptor (B1R) on cardioprotection and neuroprotection in I/R with or without diabetes, this study was designed to investigate the role of TK during cerebral I/R injury in streptozotocin-induced diabetic rats. Intravenous injection of TK inhibited apoptosis in neurons, alleviated edema and inflammatory reactions after focal cerebral I/R, significantly reduced the infarct volume, and improved functional recovery. These beneficial effects were accompanied by activation of the extracellular signal-regulated kinase 1/2 (ERK1/2), cAMP response element-binding (CREB), and Bcl-2 signal proteins. Inhibition of the B2R or ERK1/2 pathway abated the effects of TK, whereas an antagonist of B1R enhanced the effects. These findings reveal that the neuroprotective effect of TK against cerebral I/R injury in streptozotocin-induced diabetic rats mainly involves the enhancement of B2R and ERK1/2-CREB-Bcl-2 signaling pathway activity.
Training of a neural network for pattern classification based on an entropy measure (1988)

A neural net model for pattern classification is introduced. Unlike models in which the network topology is specified before training, in this model the network expands during training. The proposed model introduces a novel type of unit (neuron) and a standard treelike feedforward network topology. The simplicity of the interconnection pattern is a particular advantage over existing models. Internal representations are formed by separating hyperplanes. Selection of the hyperplanes and expansion of the network is based on an entropy measure which is appropriately defined. The weight vectors of all units with a certain layer are determined in a single presentation of the training set.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Low-temperature Hydrogenation of Toluene by Electrolysis of Water with Hydrogen Permeable Palladium Membrane Electrode (2017)

Hydrogenation of toluene proceeded with hydrogen derived from the electrolysis of water with an electrical cell that a hydrogen permeable palladium membrane was the cathode. The hydrogenation occurred with selectively permeated hydrogen through the membrane in a catalytic layer at more than 313 K and the rate of hydrogenation increased with increasing temperature. This system was stable at least several hours and about a half of hydrogen produced by the electrolysis can be used for hydrogenation.
<i>N</i>,<i>N</i>‐Dimethylformamide Additions to the Solution for the Electrospinning of Poly(<i>ε</i>‐caprolactone) Nanofibers (2004)

Abstract Summary: Additives that exhibit polyelectrolyte behavior such as N , N ‐dimethylformamide (DMF) may improve the electrospinning characteristics of viscoelastic polymer solutions. DMF additions to the solution lead to extensive jet splaying, thereby reducing the fiber diameter significantly. Nanofibrous structures with diameters of the order of 150 nm can be produced by the addition of about 10 vol.‐% DMF to the solvent (chloroform). DMF additions also yield a narrow, unimodal distribution of fibers, compared to the bimodal distribution typically detected in electrospun polymers. Jet breakdown without (left) and with DMF addition to the solution. image Jet breakdown without (left) and with DMF addition to the solution.
Pulmonary manifestations of systemic autoimmune diseases. (2011)

Systemic autoimmune diseases (SAD) are a heterogeneous group of immunologically mediated inflammatory disorders including multiorgan involvement. As expected in a multisystem disease, the entire pulmonary system is vulnerable to injury. Any of its compartments may be independently or simultaneously affected. It is difficult to assess the true prevalence of lung disease in cases of SAD. In this article, we will review the pulmonary manifestations caused by systemic lupus erithematosus, rheumatoid arthritis, systemic sclerosis, polymyositis/dermatomyositis, Sjögren's syndrome, mixed connective tissue disease, Wegener's granulomatosis, Churg-Strauss syndrome, Goodpasture's syndrome, and ankylosing spondylitis.
Advanced Canning Systems for Ceramic Monoliths in Catalytic Converters (1988)

<div class="htmlview paragraph">An advanced design for mounting ceramic monoliths in catalytic converters has been developed. This design specifically addresses the oval cross sections of ceramic monoliths and features the mat mounting system. It has also been developed for the extreme thermal and mechanical requirements given by the European driving conditions.</div> <div class="htmlview paragraph">This paper demonstrates the advantages of these advanced canning systems in comparison to conventional systems.</div> <div class="htmlview paragraph">A basic requirement for the successful application of the mat mounting system is the thorough knowledge of the technical characteristics and the behaviour of the components and good engineering of the entire system.</div> <div class="htmlview paragraph">The results of the necessary engine dyno and road tests are also shown.</div>
Joint Resource Allocation for eICIC in Heterogeneous Networks (2014)

Interference coordination between high-power macros and low-power picos deeply impacts the performance of heterogeneous networks (HetNets). It should deal with three challenges: user association with macros and picos, the amount of almost blank subframe (ABS) that macros should reserve for picos, and resource block (RB) allocation strategy in each eNB. We formulate the three issues jointly for sum weighted logarithmic utility maximization while maintaining proportional fairness of users. A class of distributed algorithms are developed to solve the joint optimization problem. Our framework can be deployed for enhanced inter-cell interference coordination (eICIC) in existing LTE-A protocols. Extensive evaluation are performed to verify the effectiveness of our algorithms.
Distinct signaling of <i>Drosophila</i> chemoreceptors in olfactory sensory neurons (2016)

In Drosophila, olfactory sensory neurons (OSNs) rely primarily on two types of chemoreceptors, odorant receptors (Ors) and ionotropic receptors (Irs), to convert odor stimuli into neural activity. The cellular signaling of these receptors in their native OSNs remains unclear because of the difficulty of obtaining intracellular recordings from Drosophila OSNs. Here, we developed an antennal preparation that enabled the first recordings (to our knowledge) from targeted Drosophila OSNs through a patch-clamp technique. We found that brief odor pulses triggered graded inward receptor currents with distinct response kinetics and current-voltage relationships between Or- and Ir-driven responses. When stimulated with long-step odors, the receptor current of Ir-expressing OSNs did not adapt. In contrast, Or-expressing OSNs showed a strong Ca(2+)-dependent adaptation. The adaptation-induced changes in odor sensitivity obeyed the Weber-Fechner relation; however, surprisingly, the incremental sensitivity was reduced at low odor backgrounds but increased at high odor backgrounds. Our model for odor adaptation revealed two opposing effects of adaptation, desensitization and prevention of saturation, in dynamically adjusting odor sensitivity and extending the sensory operating range.
Instantaneous torque control brushless DC drives (1989)

Permanent-magnet brushless DC drives can have excellent performance in direct-drive servo applications provided suitable control techniques are implemented. This calls for a cascade control strategy in which the controller is divided into two control loops: an outer loop which generates the instantaneous torque reference signal required to track acceleration, velocity or position; and an inner loop which forces the developed instantaneous torque to follow the torque command. In most conventional control algorithms, the inner loop is designed to produce sinusoidal stator currents, thus giving rise to significant torque ripples if the motor has a back EMF waveform which differs appreciably from the ideal sinusoid. A digital torque control scheme is proposed which uses the variable structure approach to generate the on-off switching patterns (vectors) directly with a microprocessor. At every switching instant, the optimum vector is selected to force the developed torque to follow the torque reference while keeping the direct axis current as close to zero as possible for the highest efficiency. The instantaneous torque feedback signal can be estimated from the terminal quantities of the motor. Simulation results are presented.