gebhart/patrepeval huggingface dataset:
Polyimides. Synthesis and Polymerization of 4-Carboxy-2-piperidone (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolyimides. Synthesis and Polymerization of 4-Carboxy-2-piperidoneH. K. Reimschuessel, K. P. Klein, and G. J. SchmittCite this: Macromolecules 1969, 2, 6, 567–569Publication Date (Print):November 1, 1969Publication History Published online1 May 2002Published inissue 1 November 1969https://pubs.acs.org/doi/10.1021/ma60012a002https://doi.org/10.1021/ma60012a002research-articleACS PublicationsRequest reuse permissionsArticle Views319Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Functional consequence of MDR1 expression on imatinib intracellular concentrations (2003)

In their recent article, Mahon et al[1][1] demonstrate that MDR1 gene overexpression can confer resistance to imatinib mesylate (Gleevec; Novartis, Basel, Switzerland) in leukemia cell lines. Several other cellular mechanisms of resistance to imatinib have also been identified,[2][2]-[4][3] but the
Real-time evaluation of individual cow milk for higher cheese-milk quality with increased cheese yield (2016)

Cheese was produced in a series of experiments from milk separated in real time during milking by using the Afilab MCS milk classification service (Afikim, Israel), which is installed on the milk line in every stall and sorts milk in real time into 2 target tanks: the A tank for cheese production (CM) and the B tank for fluid milk products (FM). The cheese milk was prepared in varying ratios ranging from ~10:90 to ~90:10 CM:FM by using this system. Cheese was made with corrected protein-to-fat ratio and without it, as well as from milk stored at 4°C for 1, 2, 3, 4, and 8d before production. Cheese weight at 24h increased along the separation cutoff level with no difference in moisture, and dry matter increased. The data compiled allowed a theoretical calculation of cheese yield and comparing it to the original van Slyke equation. Whenever the value of Afi-Cf, which is the optical measure of curd firmness obtained by the Afilab instrument, was used, a better predicted level of cheese yield was obtained. In addition, 27 bulk milk tanks with milk separated at a 50:50 CM:FM ratio resulted in cheese with a significantly higher fat and protein, dry matter, and weight at 24h. Moreover, solids incorporated from the milk into the cheese were significantly higher in cheeses made of milk from A tanks. The influence of storage of milk up to 8d before cheese making was tested. Gross milk composition did not change and no differences were found in cheese moisture, but dry matter and protein incorporated in the cheese dropped significantly along the storage time. These findings confirm that milk stored for several days before processing is prone to physico-chemical deterioration processes, which result in loss of milk constituents to the whey and therefore reduced product yield. The study demonstrates that introducing the unknown parameters for calculating the predicted cheese yield, such as the empiric measured Afi-Cf properties, are more accurate and the increase in cheese yield is more than increasing just the protein level, the value that is being tested by the dairies, or even casein.
Collection of remote optical signals by air waveguides (2014)

We demonstrate that long-lived air waveguides can efficiently collect remote, isotropically emitted optical signals. Signal-to-noise enhancements of ~104 are possible for standoff measurements at 100 m, with even higher increases possible at longer distances.
Halogen and Hydrogen Bonding in Multicomponent Crystals of Tetrabromo-1H-Benzotriazole (2017)

4,5,6,7-Tetrabromo-1H-benzotriazole (TBBT) is still considered a reference inhibitor of casein kinase II (CK2), a valuable target for anticancer therapy, even though the poor solubility in water of this active pharmaceutical ingredient (API) has prevented its implementation in therapy. We decided to explore the interactions preferentially formed by TBBT in crystalline solids in order to obtain information helpful for the development of new TBBT cocrystals possibly endowed with improved bioavailability. In this paper, we describe the synthesis and the structural characterization of the TBBT methanol solvate and of the TBBT salt with N,N,N’,N’-tetramethylethylenediamine. It is shown that TBBT can give rise to several competing interactions. This API is clearly a good halogen bond (XB) donor, with bromine atoms adjacent to the triazole ring possibly better donors than the two others. TBBT is also a good hydrogen bond (HB) donor, with the triazole hydrogen forming an HB with the acceptor or being transferred to it. Interestingly, one of the triazole nitrogens was proven to be able to work as a hydrogen bond acceptor.
Infrared Spectroscopic Imaging of the Biochemical Modifications Induced in the Cerebellum of the Niemann–Pick type C Mouse (1999)

We have applied Fourier transform infrared (IR) spectroscopic imaging to the investigation of the neuropathologic effects of a genetic lipid storage disease, Niemann-Pick type C (NPC). Tissue sections both from the cerebella of a strain of BALB/c mice that demonstrated morphology and pathology of the human disease and from control animals were used. These samples were analyzed by standard histopathological procedures as well as this new IR imaging approach. The IR absorbance images exhibit contrast based on biochemical variations and allow for the identification of the cellular layers within the tissue samples. Furthermore, these images provide a qualitative description of the localized biochemical differences existing between the diseased and control tissue in the absence of histological staining. Statistical analyses of the IR spectra extracted from individual cell layers of the imaging data sets provide concise quantitative descriptions of these biochemical changes. The results indicate that lipid is depleted specifically in the white matter of the NPC mouse in comparison to the control samples. Minor differences were noted for the granular layers, but no significant differences were observed in the molecular layers of the cerebellar tissue. These changes are consistent with significant demyelination within the cerebellum of the NPC mouse. © 1999 Society of Photo-Optical Instrumentation Engineers.
Synthesis and Characterization of [(η<sup>6</sup>-arene)RuCl<sub>2</sub>(R<sub>2</sub>AsCHCH<sub>2</sub>)] and Tethered Arsinopropylarene−Ruthenium(II) Complexes (2002)

The complexes [(η6-arene)RuCl2(R2AsCHCH2)] [arene = MeC6H5, R = Ph (1a), R = Cy (1b); p-MeC6H4Me, R = Ph (2a), R = Cy (2b); o-MeC6H4Me, R = Ph (3a), R = Cy (3b); 1,3,5-Me3C6H3, R = Ph (4a); p-MeC6H4CHMe2, R = Ph (5a), R = Cy (5b); 1,2,4,5-Me4C6H2, R = Ph (6a), R = Cy (6b); C6Me6, R = Ph (7a)] have been synthesized by reacting [(η6-arene)RuCl2]2 with the respective vinyl arsine. The compounds [(η6-MeC6H5)RuCl2(Ph2AsCHCH2)] (1a) and [(η6-1,3,5-Me3C6H3)RuCl2(Ph2AsCHCH2)] (4a) undergo KOBut-promoted intramolecular hydroalkylation in boiling acetonitrile to produce tethered arsinopropylarene−ruthenium(II) complexes 1c and 4c, respectively. The complexes have been characterized by 1H and 13C{1H} NMR spectroscopy, elemental analyses, cyclic voltammetry, and in several cases by X-ray crystallography.
Röntgenstrukturanalyse des Bis‐[10‐methyl‐acridin‐(9)]‐monoaza‐monomethincyanin‐perchlorats (1972)

Abstract Die Röntgenstrukturanalyse des Bis‐[10‐methyl‐acridin‐(9)]‐monoazamonomethincyanin‐perchlorats wird beschrieben und die Molekül‐ und Kristallstruktur diskutiert. Raumgruppe: P2 1 2 1 2 1 , a = 19.76 5 , b = 13.94 5 , c = 8.43 6 Å mit 4 Formeleinheiten pro Elementarzelle. Die sterische Hinderung im Kation führt zu einem Kompromiß zwischen Verdrillung der Teilsysteme (65.5°) und Aufweitung von Winkeln (z. B. am zentralen Stickstoff 136.5°). Außerdem wurden am Farbkation PPP‐Rechnungen durchgeführt. Ein UV‐Kristallspektrum ist einem Lösungsspektrum gegenübergestellt. Die Raumgruppe ist azentrisch und führt daher zum Einbau gleicher optischer Antipoden aus einer racemischen Lösung.
Coherence-multiplexed fiber-optic sensor systems for measurements of dynamic pressure and temperature changes (2002)

Two systems of multiplexed interferometric sensors based on highly birefringent fibers for simultaneous measurements of pressure and temperature changes are presented. The phase shifts induced in the sensing elements are registered in a four-channel detection unit with a resolution of 1/4 interference fringe. The performance of two systems, one composed of two serially multiplexed sensors for measurements of pressure and temperature changes and the other composed of two parallel multiplexed sensors for pressure measurements is demonstrated.
Copper-catalysed coupling of undec-10-enylmagnesium bromide with ω-functionalised halogenoalkanes as a key reaction for the synthesis of novel bipolar phospholipids with different head groups and chain length (1997)

The Grignard reagent from 11-bromoundec-1-ene undergoes copper-catalysed coupling with ω-functionalised halogenoalkanes of different chain length to provide long-chain ω-substituted alkenes. The reaction conditions for this have been studied to optimise the products yields, especially those for the preparation of the C32 unit. Functionalised alkenes are suitable building blocks for the direct synthesis of bipolar phospholipids with different head groups.
A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides (2011)

Simple and efficient: The combination of an enzymatic, enantioinverting reaction with simple follow-up processes allows the transformation of readily available racemic compounds into versatile chiral α-substituted amides (see picture; Ms=methanesulfonyl). These important building blocks are prepared in high overall yield and enantiomeric excess; the elimination of intermediate purification steps results in a time- and cost-efficient process. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Perspectives and tradeoffs of absorber materials for high NA EUV lithography (2020)

Next-generation extreme ultraviolet (EUV) systems with numerical apertures of 0.55 have the potential to provide sub-8-nm half-pitch resolution. The increased importance of stochastic effects at smaller feature sizes places further demands on scanner and mask to provide high contrast images. We use rigorous mask diffraction and imaging simulation to understand the impact of the EUV mask absorber and to identify the most appropriate optical parameters for high NA EUV imaging. Simulations of various use cases and material options indicate two main types of solutions: high extinction materials, especially for lines spaces, and low refractive index materials that can provide phase shift mask solutions. EUV phase masks behave very different from phase shift masks for DUV. Carefully designed low refractive index materials and masks can open up a new path toward high contrast edge printing.
Characterisation and reliability evaluation of a verticle multichip module (NCM-TV) technique using test chips (2005)

A test chip designed for characterisation. and reliability evaluation of a 3-dimensional vertical multichip module (MCM-V) technique and it's application in ESPRIT Project TRIMOD - TRI-dimensional multichip MODules will be described. The design of the test chip itself, of technology demonstrator (TD) modules incorporating the test chips and the results of thermal, thermomechanical and electrical characterisation and reliability testing will be presented. In addition, the correlation between thermal and thermomechanical modelling and measured results from the TD modules will be discussed.
Resveratrol, 4′ Acetoxy Resveratrol, R-equol, Racemic Equol or S-equol as Cosmeceuticals to Improve Dermal Health (2017)

Phytochemicals are botanical compounds used in dermatology applications as cosmeceuticals to improve skin health. Resveratrol and equol are two of the best-known polyphenolic or phytoestrogens having similar chemical structures and some overlapping biological functions to 17β-estradiol. Human skin gene expression was reviewed for 28 different biomarkers when resveratrol, 4' acetoxy resveratrol (4AR), <i>R</i>-equol, racemic equol or <i>S</i>-equol were tested. Sirtuin 1 activator (SIRT 1) was stimulated by resveratrol and 4AR only. Resveratrol, <i>R</i>-equol and racemic equol were effective on the aging biomarkers proliferating cell nuclear factor (PCNA), nerve growth factor (NGF), 5α-reductase and the calcium binding proteins S100 A8 and A9. Racemic equol and 4AR displayed among the highest levels for the collagens, elastin and tissue inhibitor of the matrix metalloproteinase 1 (TIMP 1). <i>S</i>-equol displayed the lowest level of effectiveness compared to the other compounds. The 4AR analog was more effective compared to resveratrol by 1.6-fold. <i>R</i>-equol and racemic equol were almost equal in potency displaying greater inhibition vs. resveratrol or its 4' analog for the matrix metalloproteinases (MMPs), but among the inflammatory biomarkers, resveratrol, 4AR, <i>R</i>-equol and racemic equol displayed high inhibition. Thus, these cosmeceuticals display promise to improve dermal health; however, further study is warranted to understand how phytochemicals protect/enhance the skin.
In Vitro Cytotoxicity of a New Epoxy Resin Root Canal Sealer (2000)

The cytotoxic effects of a new epoxy resin-based root canal sealer (AH-plus), together with those of two other commonly used endodontic sealers (AH26 and zinc oxide-eugenol), have been studied in vitro on a culture of human gingival fibroblasts. Cytotoxicity was assessed by direct incubation of sealers' extracts with the cultured fibroblasts at different time intervals. Morphological and cytotoxic effects of the sealers were evaluated microscopically and spectrophotometrically using the neutral red cytotoxicity assay. Our results demonstrated that the cytotoxic effects induced by zinc oxide-eugenol were detectable as early as 1 hr after mixing and remained at a high level until completion of the experiment (5 wk). AH26, however, induced early cytotoxic effects that lasted for 1 wk, followed by a substantial reduction in cytotoxicity. Cytotoxicity of the AH-plus was confined to the early period of experiment and was no longer detectable after 4 hr of mixing. Comparison between the results obtained for each sealer revealed significant differences at particular time intervals. Our findings suggest the potential advantage of this sealer over the other two sealers.
International Clinical Practice Guidelines for the Treatment and Prophylaxis of Thrombosis Associated with Central Venous Catheters in Patients with Cancer (2012)

Abstract Abstract 4357 Background Use of long term indwelling central venous catheter (CVC) is associated with symptomatic (Σ) events in up to 30% of cancer patients (pts), which may lead to pulmonary embolism (PE) and loss of the CVC. Lack of consensus on management of CVC related thrombosis (CVCT) and heterogeneity in clinical practices worldwide led us to establish international Good Clinical Practices Guidelines (GCPG) for the management of CRT in cancer pts. Methods The international working group (WG) met 4 times and worked 2 years with the methodological support and quality control of the French institute of Cancer (INCa). All studies on cancer, venous thromboembolism (VTE, including pulmonary embolism PE), and anticoagulant drugs (AC) published from 1996 to 2011 weree searched using MEDLINE®database. Meta-analyses, systematic reviews, randomized or non-randomized prospective or retrospective studies in the absence of randomized clinical trials, and abstracts only if a full paper had been accepted in a peer-reviewed medical journal were included in the analysis. The included studies concerned the prophylaxis and treatment of CVC in cancer pts. Studies in non-cancer pts, pts with a peripheral or dialysis catheter, or with a history of cancer in remission for more than 5 years were not considered. The main study outcomes were rates of proven catheter related thrombosis (CRT), extension of CRT, PE associated with CRT, major and minor bleeding, thrombocytopenia, and death. Quality of the studies was evaluated in a double-blind manner by the methodologists using the GRADE appraisal grids. Extracted data were entered in evidence tables, subsequently validated by all the WG. The level of evidence (High A, Moderate B, Low C, Very low D) depended on study design, limitations, inconsistency, indirectness, imprecision and publication bias. For each question, results analysis were summarized and discussed by the WG. Overall conclusions and recommendations were classified as Strong (Grade 1 Guideline) or Weak (Grade 2 Guideline) based on evidence levels, the balance between desirable/undesirable effects, values and preferencesand costs. In the absence of scientific evidence, judgment based on consensus within the WG was defined as Best Clinical Practice (BCP). The GCP were reviewed and evaluated using a specific grid in February 2012 by 45 independent experts in managing cancer pts worldwide and 3 pt representatives. Results Conclusion Dissemination and implementation of these international GCPG on the prevention and treatment of CRT in cancer ptsat each national level is a major public health priority, necssitating world wide collaboration. Disclosures: No relevant conflicts of interest to declare.
Newcastle disease: effects of vaccines and vaccination techniques of hemagglutination-inhibition (HI) antibodies and clinical resistance. (1975)

Different vaccines (the lentogenic Hitchner-, the avirulent Ulster- and the mesogenic Beaudette strain) and different vaccination schemes (spray, dip, drinking water) were used in 1380 broiler-type chicks on the first day of life and at four weeks. In all these experiments an immunity status was induced sufficient to resist to a strong individual challenge infection, two weeks after the second vaccination. This uniform resistance showed no correlation with the very heterogeneous HI titers which were obtained two weeks after the second vaccination. The titers were, however, strongly dependent both of the vaccine strain used and on the vaccination method. The Beaudette spray-vaccinations provoked the highest titers. The highest post-challenge titers were seen after vaccinations with the lentogenic and avirulent strains and the lowest after-challenge titers were seen when the mesogenic Beaudette strain was used. Birds with high HI titers showed a marked decrease of these HI titers two weeks after challenge, while there was an increase of HI titers in birds with low post-vaccinal titers. It may be concluded that clinical resistance to NCD infection is not directly correlated with high-vaccinal HI titers. Experimental infection by natural route is essential to judge the immune status of fowls.
The activity of factor VIII and IX of cord blood at mid-trimester in fetuses without hemophilia (2016)

hemophilia is defined as having less than 1% of normal plasma concentrations Patients with plasma concentrations less than 5% or 7% but equal to or greater than 1% of the normal levels are classified as having moderately severe hemophilia; those with higher concentrations are categorized as having mild hemophilia [3]. Among patients with hemophilia A, 35% have severe, 15% have moderate, and 55% have mild forms of the disease Although patients with mild hemophilia rarely encounter spontaneous bleeding episodes and the condition can sometimes even go unnoticed, severe forms of the disease cause recurrent bleeding in the joints, connective tissues, and other systems. These patients require lifelong treatment, with the main principle behind these therapies being the replacement
Cost and Performance Report for a Persulfate Treatability Study at Naval Air Station North Island (2008)

Abstract : A pilot treatability study of persulfate was conducted at Operable Unit 20, Naval Air Station North Island between November 2006 and June 2007. The treatment was targeted for removal of chlorinated volative organic compounds (CVOCs) from groundwater (primarily trichlorethylene) located at a depth of up to 54 feet below ground surface. This report summarizes the cost and performance data from this treatability study.
Estimating the Rotational Synchronous Component from Instantaneous Angular Speed Signals in Variable Speed Conditions (2018)

International audience
S1P receptor agonists, a novel generation of immunosuppressants (2010)

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Some design aspects on anchoring of timber frame shear walls by transverse walls (2010)

This doctoral thesis addresses questions of how wind loads acting on multistoreytimber buildings can be dealt with by structural design of such buildings.The conventional use of sheathing either nailed or screwed to a timberframework is considered, together with other stabilizing structures such ascross-laminated timber panels.The finite element method was employed in simulating the structuralbehaviour of stabilizing wall units. A series of studies was carried out of walls inwhich the sheathing was nailed to a timber frame. Different structural levelswere studied starting with modelling the performance of single sheathing-toframingconnections, to the use of models for studying the overall structuralbehaviour of walls. The results of calculations using models for simulation ofwalls subjected to different loading agree reasonably well with experimentalresults. The structural properties of the connections between the sheathing andthe frame, as well as of the connections between the members of the frame,were shown to have a substantial effect on the simulated behaviour of shearwall units. Both these types of connections were studied and described inappended papers.Regarding cross-laminated timber wall panels, it was concluded that walls witha high level of both stiffness and strength can be produced by the use of suchpanels, and also that the connections between the solid wall panels can bedesigned in such a way that the shear forces involved are transmitted from onepanel to the next in an efficient manner.Other topics in the thesis include the properties of connections between shearwalls and the rest of the building. Typically high tension forces occur at specificpoints in a timber structure. These forces need to be transmitted downwards inthe structure, ultimately connecting them to the substrate. A lap-joint that maybe used for this purpose has been studied using generalized Volkersen theory.Finally the maximum capacity of a conventional rail to substrate connection hasbeen examined using linear and nonlinear fracture mechanics.