gebhart/patrepeval huggingface dataset:
Spectropolarimetry of Type Ibc Supernovae (2011)

Abstract Studying a multi-dimensional structure of supernovae (SNe) gives important constraints on the mechanism of the SN explosion. Polarization measurement is one of the most powerful methods to study the explosion geometry of extragalactic SNe. Especially, Type Ib/c SNe are the ideal targets because the core of the explosion is bare. We have performed spectropolarimetric observations of Type Ib/c SNe with the Subaru telescope. We detect a rotation of the polarization angle across the line, which is seen as a loop in the Q - U plane. This indicates that axisymmetry is broken in the SN ejecta. Adding our new data to the sample of stripped-envelope SNe with high-quality spectropolarimetric data, five SNe out of six show a loop in the Q - U plane. This implies that the SN explosion commonly has a non-axisymmetric, three-dimensional geometry.
Heat therapy reduces blood pressure and circulating endothelin‐1 levels, but does not improve walking performance or vascular function in patients with symptomatic peripheral artery disease (2020)

INTRODUCTION Patients with peripheral artery disease (PAD) are at a heightened risk of cardiovascular events and have markedly reduced vascular function and exercise tolerance. Heat therapy (HT) has emerged as a practical treatment to improve cardiovascular health in young individuals as well in patients with overt cardiovascular disease. We recently reported that a single 90 min session of HT applied to the legs of patients with PAD using water‐circulating trousers increases popliteal artery blood flow and reduces blood pressure and the circulating levels of the potent endogenous vasoconstrictor endothelin‐1 (ET‐1). The objective of the present study was to test the hypothesis that the repeated exposure to leg HT would lower blood pressure and ET‐1 levels and improve walking performance and conduit artery and cutaneous vascular function in patients with symptomatic PAD. METHODS Thirty‐two patients with symptomatic PAD (Age: 68± 8 years; Ankle‐brachial index: 0.67 ± 0.1) were assigned using a balanced randomized design to undergo 90 min of HT (48°C) or a thermoneutral treatment (33°C) 3 times per week for 6 consecutive weeks. The following outcomes were assessed at baseline and 3 and 6 weeks after the intervention: 1) resting ankle‐brachial index, 2) post‐occlusive reactive hyperemia in the popliteal artery (phase contrast magnetic resonance imaging), 3) leg cutaneous thermal hyperemia (laser Doppler flowmetry), 4) resting blood pressure every 5 min for 70 min, 5) 6‐min walk distance and 6) serum levels of ET‐1 and total nitrate (NOx). RESULTS Participants completed 17.7 ± 0.6 treatment sessions, resulting in a compliance rate of 98.7%. In the group exposed to HT, systolic blood pressure (SBP) decreased from baseline by ~3 mmHg at 6 weeks, while in the control group SBP increased by ~1 mmHg. A significant group by time interaction was observed for the changes in SBP from baseline to 6 weeks ( p=0.0049) with significant group differences at 20 min (Change in SBP: Control: 6.27 ± 15.5 vs. HT: −7.60 ± 13.6 mmHg, p=0.015 ) and 60 min (Change in SBP: Control: 4.13 ± 15.1 vs. HT: −7.33 ± 13.7 mmHg, p=0.0386 ). Similarly, serum ET‐1 levels decreased by ~15% from baseline to week 6 following exposure to HT, while a ~6% increase in this parameter occurred in the control group (Change in ET‐1: Control: 0.16 ± 0.6 vs. HT: −0.30 ± 0.4 pg/mL, p=0.035 – one outlier removed). Resting ABI, diastolic BP, 6MWT distance, hyperemic peak flow and cutaneous thermal hyperemia were not different between groups. CONCLUSION Exposure to repeated HT reduces systolic blood pressure and ET‐1 levels in patients with symptomatic PAD. These findings indicate that HT may be a practical and accessible nonpharmacological tool to reduce cardiovascular risk in PAD patients. Support or Funding Information American Heart Association Scientist Development grant (16SDG27600003).
MALDI mass spectrometric imaging based identification of clinically relevant signals in prostate cancer using large‐scale tissue microarrays (2013)

To identify molecular features associated with clinico-pathological parameters and TMPRSS2-ERG fusion status in prostate cancer, we employed MALDI mass spectrometric imaging (MSI) to a prostate cancer tissue microarray (TMA) containing formalin-fixed, paraffin-embedded tissues samples from 1,044 patients for which clinical follow-up data were available. MSI analysis revealed 15 distinct mass per charge (m/z)-signals associated to epithelial structures. A comparison of these signals with clinico-pathological features revealed statistical association with favorable tumor phenotype such as low Gleason grade, early pT stage or low Ki67 labeling Index (LI) for four signals (m/z 700, m/z 1,502, m/z 1,199 and m/z 3,577), a link between high Ki67LI for one signal (m/z 1,013) and a relationship with prolonged time to PSA recurrence for one signal (m/z 1,502; p = 0.0145). Multiple signals were associated with the ERG-fusion status of our cancers. Two of 15 epithelium-associated signals including m/z 1,013 and m/z 1,502 were associated with detectable ERG expression and five signals (m/z 644, 678, 1,044, 3,086 and 3,577) were associated with ERG negativity. These observations are in line with substantial molecular differences between fusion-type and non-fusion type prostate cancer. The signals observed in this study may characterize molecules that play a role in the development of TMPRSS2-ERG fusions, or alternatively reflect pathways that are activated as a consequence of ERG-activation. The combination of MSI and large-scale TMAs reflects a powerful approach enabling immediate prioritization of MSI signals based on associations with clinico-pathological and molecular data.
The Efficacy of Antiarrhythmic Agents During Acute Myocardial Ischemia and the Role of Heart Rate (1974)

The influence of lidocaine, procaine amide, and propranolol on ventricular arrhythmias during acute myocardial ischemia in the dog was examined. Ischemic zone epicardial (IZE) activation delay and the time of onset of ventricular tachycardia (VT t ) were studied. Progressive IZE delay always preceded ventricular tachycardia (VT). Ventricular tachycardia occurred when IZE delay extended into the T wave of the standard electrocardiogram but areas of ischemic epicardium were found in which activation delayed beyond the T wave. Fast heart rates during acute ischemia were associated with an accelerated time course of IZE delay and early VT. Slow heart rates resulted in minimal IZE delay and delayed onset or absence of VT. Sympathectomized dogs with heart rates 32% slower than normal dogs did not develop significant IZE delay or VT during ischemia. When heart rates were increased by atrial pacing, these dogs behaved in the same fashion as the normal dogs with respect to IZE delay and VT t . Lidocaine was found to hasten the time course of IZE delay but to have no significant effect on VT t . Procaine amide did not influence IZE delay nor VT t during ischemia. Propranolol slowed the mean heart rate by 20% and appeared to protect against arrhythmia. When the heart rate (115 ± 10 beats/min; mean ± standard deviation) was increased by atrial pacing (184 ± 9 beats/min), propranolol did not significantly influence IZE delay or VT t as compared to the untreated controls. The clinical counterpart of our experiments during acute ischemia may relate to the prehospitalization phase of myocardial infarction.
STEM DESIGN CONSIDERATIONS IN EARLY LOOSENING OF CEMENTED TOTAL HIP REPLACEMENTS (2004)

The perception that all cemented stems have reasonable assurance of success if implanted with contemporary cement technique has recently been questioned. Surface finish, stem shape, patient weight and high neck offset have been identified as factors contributing to early loosening. Small design changes to existing cemented stems have led to substantial differences in clinical performance. This study investigates the multi-factorial nature of stem loosening after a 24% early failure rate occurred within the initial three years. Total hip arthroplasty was performed by the same surgeon on 67 patients with an average age and weight of 65 years (21-85) and 82 kg (49-127), respectively. Initial diagnosis was osteoarthritis (84%), osteonecrosis (7%), congenital dysplasia (4%), and other (5%). Modern femoral stems (Perfecta IMC) with increased lateral neck offset were implanted using contemporary cementing techniques. The stems are grit-blasted proximally, with intramedullary collar steps on the anterior/posterior surface. These design features are meant to enhance axial load transfer and stem-cement bonding. All acetabular cups were uncemented and used polyethylene (48 patients) or cobalt-chrome (20 patients) liners. Patients were evaluated with clinical and radiographic follow-up. Revision for stem loosening was necessary in 16(24%) patients 9 to 38 months after index surgery, including 9 hips revised within the first 18 months. Radiolucencies at the cement/bone interface, stem subsidence and distal femoral osteolysis were consistently observed. Patients with loosening were significantly heavier than those with well-fixed stems (93 kg versus 78 kg, respectively). Revised hips included 7 cobalt-chrome and 9 polyethylene articulations. It appears that several mechanical factors contributed to these early failures. Lateral offset stems with cement fixation appear to be at risk for loosening in young, heavy patients. Design features and a thin cement mantle may have resulted in increased cement stresses and cracks during the axial and torsional loading that occur with daily activities.
Dreaming and waking consciousness: a character recognition study (2000)

The formal features of dream characters were studied in a sample of 320 dream reports submitted by 33 adult subjects (13 male, 20 female) of varying ages in a university extension course. Subjects were queried by questionnaire about dream characters immediately after recording their dreams upon awakening in their normal home setting. It was found that 48% of characters represented a named personage known to the dreamer, 35% were generically identified by their social role (e.g., policeman) or abstract relation to the dreamer (e.g., a friend) while only 16% were wholly novel. Seventy-seven percent of characters were pseudosensorily present in the dream whereas 23% were present only by mention or thought. Subjects were allowed to endorse one or more of four bases of recognition and, among named characters, 32% were identified by 'appearance', 21% by 'behavior', 45% by 'face', and 44% by 'just knowing' (with the respective percentages for generic characters being 39%, 38%, 9% and 40%). Fourteen percent of named and generic characters had associated some element of bizarreness most frequently consisting of an incongruous feature. Comparing the 25 longest and 25 shortest reports, named subjects were significantly more common in the shortest reports whereas generic and unknown characters were more common in the longest reports. Results are interpreted in neurocognitive terms as possibly reflecting a decrease during dreaming relative to waking in the exchange of information between inferotemporal face identification areas and prefrontal areas subserving logic and working memory.
Improving memory performance through runtime optimization (2002)

Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.
Methods of 100 dB RF performance verification of facility filters (2002)

EMI/RFI facility filters specified to 100 dB are used in government and commercial installations to prevent unwanted signals on power lines. The main standard used to measure filter insertion loss (synonymous for matched impedance attenuation), is MIL-STD-220A. But because MIL-STD-220A was developed only for matched impedance communication systems, it has been labeled unrealistic. Since then, other standards and methods have been developed that attempt to model "real world" attenuation by requiring varying source and load impedance. To date, however, none of these measuring methods have replaced MIL-STD-220A. This paper supports the continued use of the much-beleaguered MIL-STD-220A as the preferred choice for high frequency performance characterization. Additionally, this paper illustrates why none of the existing methods are sufficient to fully verify 100 dB attenuation. Furthermore, in recognizing MIL-STD-220A's shortcomings, this paper suggests the development of a new facility filter standard that addresses power quality issues, critical RF performance factors and filter/shielded room equipment incompatibility issues that previously have not been considered.
Ten years of viewing from within : the legacy of Francisco Varela (2009)

The View from Within, edited by the late Francisco Varela in collaboration with Jonathan Shear, was published in 1999 and has proved a major stimulus to the scientific investigation of first-person methodologies in psychology and philosophy of mind. Ten years on, Claire Petitmengin has organized a collection of essays that examine and refine the research program on first-person methods defined in The View from Within, with contributions based on empirical research. She has kept close to the spirit of the earlier book, in which Varela encouraged a precise description of the very process of becoming aware of one's experience and describing it.
Organometallic Compounds of Group III, IV, and V (1962)

Abstract : The preparation and reactions of a number of organometallic compounds has been studied. The organolithium. compounds under investigation are Ph2CHLi Ph3CLi, Ph3SnLi, Ph3GeLi, Ph3PbLi, Ph2PU and Ph2NLi. Also included in this serie 8 is Ph2NNa. The reactions of these organometallics with various compounds as carbon dioxide, water, alkyl halides, aryl halides, aralkyl halides, metallic halides and esters has been studied.
COMMISSIONING PROGRESS OF THE FEMTOSLICING AT SOLEIL (2014)

The femtoslicing project at SOLEIL is currently under commissioning. It will enable to serve several beamlines with 100 fs FWHM long pulses of soft and hard X-rays with reasonable flux and with a 1 kHz repetition rate. It is based on the interaction of a femtosecond Ti:Sa laser with electrons circulating in the magnetic field of a modulator wiggler, that provides the electron beam energy modulation on the length scale of the laser pulse. The optimization of the interaction is performed using two dedicated diagnostics stations. The first one, operating in the Infra-Red (IR) is installed in the tunnel and allows the adjustment of the temporal, spectral and spatial overlap between the laser and the electron beam. The second one, located in the IR-THz AILES beamline, measures the intensity of the terahertz (THz) radiation emitted by the local dip structure produced in the core electron beam after interaction. This second setup provides refined optimization of the interaction. This paper describes the layout of these diagnostics and gives first results and characterization of the slicing experiment at SOLEIL.
The Smiling Face in Marketing Appeals and its Effects on the Customer (2003)

Joy appeals appear frequently in marketing, but they have received little attention from marketing researches compared to other emotional appeals (e.g., sexy appeals, humor appeals, and attraction appeals with decorative models). This study examines one particular aspect of the joy appeal in a marketing context, the smiling face stimulus. The main findings are that the smiling face is more effective than non-smiling faces in eliciting (1) a positive attitude toward the smiling stimulus person, (2) a positive overall attitude to the firm using the smile appeal, and (3) intentions to patronize and recommend this firm. 3 The Smiling Face in Marketing Appeals and its Effects on the Customer Emotions have for some time attracted the attention of marketing researchers, particularly those who are active in the advertising effectiveness tradition, and it is clear that many marketing appeals elicit emotions. In fact, it is difficult for a marketing appeal not to produce at least some level of emotion (Zeitlin and Westwood 1986). It is also clear that the customer’s emotions affect subsequent responses in terms of several variables in hierarchy-ofeffects models (Brown and Stayman 1992; Holbrook and Batra 1987).
Robust Nonlinear Control of Tailless Aircraft (1999)

Abstract : The objective of this research was to develop tools leading to effective control strategies for tailless fighter aircraft. Emphasis was placed on the development of control algorithms that yield robust performance in the presence of actuator magnitude and rate limits and that account for the interaction of a pilot with the airframe and control system. The results of this research are documented in the 22 papers that are listed in this report. These papers present the development of numerous new analysis tools for nonlinear control systems with an emphasis on disturbance attenuation and sampled data control. These algorithms were applied to the manual flight control problem for open loop unstable fighter aircraft.
Thermal properties measurements of solid rocket propellant oxidizers and binder materials as a function of temperature (1999)

Abstract Using a fairly simple technique and small samples it was possible to obtain thermal diffusivity, specific heat capacity, and thermal conductivity, all as a function of sample temperature, for a variety of ingredients used in solid rocket propellants. The oxidizers AP, ADN, CL20, HMX, RDX, HNF, TNAZ were studied as well as the nonenergetic polymers TeflonTM, HTPB, and polyurethane, energetic binders containing GAP and BAMO and/or NMMO, and actual solid propellants XM39, N5, N12, and SB129.
Corrigenda (1995)

B. J. Maxwell, C. H. Schiesser, B. A. Smart, J. Tsanaktsidis, O. S. Mills, N. J. Mooney, P. M. Robinson, C. I. F. Watt and B. G. Cox, J. Chem. Soc., Perkin Trans. 2, 1995, 1245 DOI: 10.1039/P29950001245
Comment on "Detection, Stimulation, and Inhibition of Neuronal Signals with High-Density Nanowire Transistor Arrays" (2009)

Patolsky et al . (Reports, 25 August 2006, p. 1100) used silicon nanowires to record action potentials in rat neuronal axons and found increases in conductance of about 85 nanosiemens. We point out that the data correspond to voltage changes of about –85 millivolts on the nanowire and that conceivable mechanisms of axon-nanowire interaction lead to signals that are opposite in sign or smaller by orders of magnitude.
Water diffusion in a synthetic hectorite by neutron scattering - beyond the isotropic translational model (2007)

Poster
The effect of instruction fetch strategies upon the performance of pipelined instruction units (1977)

The interpretation of a machine instruction requires fetching the instruction, decoding the instruction, and then executing it. In addition, if the instruction requires one or more operands, their addresses must be generated and the operands fetched. A large number of processors have been designed to perform some or all of these functions simultaneously on successive instructions. These pipelined processor architectures would appear to permit the decoding of a new instruction each machine cycle.
Novel Cell‐Penetrating α‐Keto‐amide Calpain Inhibitors as Potential Treatment for Muscular Dystrophy. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Modeling of the Coupling Mechanisms between Lightning and a Complex Telecommunication Network. (2008)

International audience
Size Exclusion Chromatography of Polystyrenes with Supercritical Dichloromethane (1989)

Dichloromethane is proposed as the mobile phase for size exclusion separation under supercritical fluid chromatographic conditions. The effect of pressure on the elution of high molecular weight polystyrene and benzene is examined. Size exclusion is a dominant mechanism for eluting nondispersive polystyrene swith a molecular weight less than 110,000 when the solvent is compressed above 320 kg/cm2 at 244°C. Separations carried out under liquid and supercritical fluid chromatographic conditions are compared in terms of the fractionation range and resolution.
Faculty Opinions recommendation of Tissue damage signaling is a prerequisite for protective neutrophil recruitment to microbial infection in zebrafish. (2018)

Tissue damage and infection are deemed likewise triggers of innate immune responses. But whereas neutrophil responses to microbes are generally protective, neutrophil recruitment into damaged tissues without infection is deleterious. Why neutrophils respond to tissue damage and not just to microbes is unknown. Is it a flaw of the innate immune system that persists because evolution did not select against it, or does it provide a selective advantage? Here, we dissect the contribution of tissue damage signaling to antimicrobial immune responses in a live vertebrate. By intravital imaging of zebrafish larvae, a powerful model for innate immunity, we show that prevention of tissue damage signaling upon microbial ear infection abrogates leukocyte chemotaxis, and reduces animal survival, at least in part, through suppression of cytosolic phospholipase A 2 (cPla 2 ), which integrates tissue damage-and microbe-derived cues. Thus, microbial cues are insufficient, and damage signaling is essential for antimicrobial neutrophil responses in zebrafish.
ChemInform Abstract: REDUCTIVE ACYLATION OF THE ALIPHATIC DIAZO FUNCTION. N‐(2‐DIAZO‐3‐OXOALKANOYL)GLYCINE ESTERS AS SYNTHETIC PRECURSORS OF (Γ‐(ARYLOXY)THREONYL)GLYCINE DERIVATIVES (1978)

Abstract Die kataly tische Reduktion der Diazoverbindungen (I) liefert die Hydrazone (II).
Discovering Sequenced Origami Folding Through Nonlinear Mechanics and Topology Optimization (2018)

Origami folding provides a novel method to transform two-dimensional (2D) sheets into complex functional structures. However, the enormity of the foldable design space necessitates development of algorithms to efficiently discover new origami fold patterns with specific performance objectives. To address this challenge, this work combines a recently developed efficient modified truss finite element model with a ground structure-based topology optimization framework. A nonlinear mechanics model is required to model the sequenced motion and large folding common in the actuation of origami structures. These highly nonlinear motions limit the ability to define convex objective functions, and parallelizable evolutionary optimization algorithms for traversing nonconvex origami design problems are developed and considered. The ability of this framework to discover fold topologies that maximize targeted actuation is verified for the well-known “Chomper” and “Square Twist” patterns. A simple twist-based design is also discovered using the verified framework. Through these case studies, the role of critical points and bifurcations emanating from sequenced deformation mechanisms (including interplay of folding, facet bending, and stretching) on design optimization is analyzed. In addition, the performance of both gradient and evolutionary optimization algorithms are explored, and genetic algorithms (GAs) consistently yield solutions with better performance given the apparent nonconvexity of the response-design space.
Cytotoxicity effects induced by FR91 on human tumour cell lines (2010)

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