gebhart/patrepeval huggingface dataset:
Kinetics of Cardiac Output at the Onset of Exercise in Precapillary Pulmonary Hypertension (2016)

<i>Purpose.</i> Cardiac output (CO) is a cornerstone parameter in precapillary pulmonary hypertension (PH). The Modelflow (MF) method offers a reliable noninvasive determination of its beat-by-beat changes. So MF allows exploration of CO adjustment with the best temporal resolution. <i>Methods.</i> Fifteen subjects (5 PH patients, 10 healthy controls) performed a submaximal supine exercise on a cycle ergometer after 5 min of rest. CO was continuously determined by MF (CO<sub>MF</sub>). Kinetics of heart rate (HR), stroke volume (SV), and CO were determined with 3 monoexponential models. <i>Results.</i> In PH patients, we observed a sudden and transitory drop of SV upon exercise onset. This implied a transitory drop of CO whose adjustment to a new steady state depended on HR increase. The kinetics of HR and CO for PH patients was slower than that of controls for all models and for SV in model 1. SV kinetics was faster for PH patients in models 2 and 3. <i>Conclusion.</i> This is the first description of beat-by-beat cardiovascular adjustments upon exercise onset in PH. The kinetics of HR and CO appeared slower than those of healthy controls and there was a transitory drop of CO upon exercise onset in PH due to a sudden drop of SV.
Clinically Useful Estimates of Insulin Sensitivity During Pregnancy (2001)

Estimates of insulin sensitivity from the IS(OGTT) during pregnancy were significantly better than from fasting glucose and insulin values. However, separate prediction equations are necessary for pregnant women with NGT and women with GDM.
Structure-Activity Relationship (SAR) Studies on Oxazolidinone Antibacterial Agents. 2. Relationship between Lipophilicity and Antibacterial Activity in 5-Thiocarbonyl Oxazolidinones. (2001)

5-Thiourea and 5-dithiocarbamate oxazolidinones were synthesized as a continuation of research on 5-thiocarbonyl oxazolidinone antibacterial agents considering the hydrophobic parameters of the molecule. The structure-activity relationship (SAR) study revealed that the antibacterial activity on 5-thiocarbonyl oxazolidinones was significantly affected by the lipophilicity, especially the calculated log P value and the balance between 5-hydrophilic (or hydrophobic) substituent and hydrophobic (or hydrophilic) substituents on the benzene ring. Some of 5-thiocarbonyl oxazolidinones were found to have good in vitro antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).
Automated analysis of natural gamm logs by gaussian processes: Application to marker shales in iron ore mines (2013)

In the banded iron formation hosted ores of the Hamersley Province, Western Australia, laterally persistent shale bands represent mappable marker units that allow the stratigraphy and the boundaries for much of the mineralisation to be established. Many of the shale bands have distinctive characteristics that create recognisable signatures in the natural gamma logs routinely obtained in exploration boreholes. Shale band identification currently involves visual interpretation of the natural gamma logs, but this process is labour intensive and subjective. An alternative objective method that can semi-automatically detect marker shale bands in natural gamma logs has therefore been developed in this thesis. Gaussian Processes (GPs) were chosen for this task as they provide probabilistic classifications with uncertainty estimations. Two methods were used to build the GP libraries. In the manual method the user first constructs a library containing a selection of natural gamma signatures. To improve the library, the results from the GP analysis are manually examined and additional signatures are added from areas of poor performance. This method was used to identify two marker shale signatures from the Marra Mamba Iron Formation, with an overall accuracy between 85.8% and 89.0% when measured against geological models developed by mine staff. In the active learning method the uncertainty of the GP output is used to highlight the areas that are poorly classified. Therefore this method is faster, which allows larger data sets to be considered. Four marker shale signatures from the Brockman and Marra Mamba Iron Formations were identified with an accuracy of 86% to 96.3%. In drill holes for which the GP is certain of the identification, the accuracy increased to between 91.6% and 98.7%. In a blind test completed on a nearby deposit, the signatures were identified with an overall accuracy of 81.0%, which increased to between 82.7% and 84.4% in the holes where the GP was certain.
Analysis of dendritic cells in solitary angiofibromas for factor VIII (1985)

We studied dendritic cells in the dermis of six angiofibromas by the peroxidase-antiperoxidase method in order to determine whether they are endothelial cells. The primary antiserum used was directed to factor VIII, an endothelial cell marker. The dendritic cells were not immunoreactive for factor VIII, suggesting that they are not endothelial cells.
Incentive Mechanism for Reliable Federated Learning: A Joint Optimization Approach to Combining Reputation and Contract Theory (2019)

Federated learning is an emerging machine learning technique that enables distributed model training using local datasets from large-scale nodes, e.g., mobile devices, but shares only model updates without uploading the raw training data. This technique provides a promising privacy preservation for mobile devices while simultaneously ensuring high learning performance. The majority of existing work has focused on designing advanced learning algorithms with an aim to achieve better learning performance. However, the challenges, such as incentive mechanisms for participating in training and worker (i.e., mobile devices) selection schemes for reliable federated learning, have not been explored yet. These challenges have hindered the widespread adoption of federated learning. To address the above challenges, in this article, we first introduce reputation as the metric to measure the reliability and trustworthiness of the mobile devices. We then design a reputation-based worker selection scheme for reliable federated learning by using a multiweight subjective logic model. We also leverage the blockchain to achieve secure reputation management for workers with nonrepudiation and tamper-resistance properties in a decentralized manner. Moreover, we propose an effective incentive mechanism combining reputation with contract theory to motivate high-reputation mobile devices with high-quality data to participate in model learning. Numerical results clearly indicate that the proposed schemes are efficient for reliable federated learning in terms of significantly improving the learning accuracy.
Stress relief cracking in creep resisting low alloy ferritic steels. (1976)

Early investigations of the phenomenon of Stress Relief Cracking in low alloy steels suggested that the observed failure along prior austenite grain boundaries was in large part promoted by the relative strengthening of the grains with respect to the grain boundaries, during the stress relieving heat treatment. In this respect, it was felt that certain Cr-Mo-V steels containing vanadium carbide should be particularly susceptible to this mode of failure, since V4 C3 is well known to confer very good creep strengthening in these low alloy steels. As a result of this work, it has been established that the above view is both inaccurate and misleading. Most of the experiments were performed on two samples of commercially produced 1/2Cr 1/2Mo 1/2V steel. One of these samples had proved to be susceptible to stress relief cracking during fabrication. Detailed observations of the austenitic grain growth and secondary hardening response of the two samples are described. The results facilitated the design of a series of high temperature hardness and tensile tests in which the separate effects of grain strengthening and grain size in promoting high temperature intergranular failure could be identified. In particular, it is observed that although both steels exhibit very similar strength characteristics, the effect of grain size in promoting low ductility in association with intergranular failure is more marked in one steel than in the other. The steel in which a marked tendency towards stress relief cracking had been observed is seen to show low ductilities at high temperatures even in fine grain size specimens ; suggesting that the state of the boundaries, independent of the strengthening effect, is an important factor in promoting high temperature intergranular failure. By using an anisothermal stress relaxation testing procedure, it was possible to identify precisely the conditions of stress,temperature and microstructure under which stress relief cracking occurs. In particular, it was observed that the susceptible sample failed by nucleation controlled intergranular cavitation in association with a particular stress/strain-rate/temperature regime where the deformation process is rate controlled by the diffusion of carbon. Further experiments described in the latter part of the thesis examine the effect of purity in promoting intergranular failure both at low and high temperatures. The results suggest that the presence of impurities like phosphorus, which are known to segregate to prior austenite grain boundaries, may act to allow easier nucleation and growth of cavities during failure by inter granular cavitation. The conclusions of the thesis outline the mechanism of stress relief cracking and make discussion in terms of current theories of intergranular failure at high temperatures. Recommendations are made concerning both the assessment of susceptibility of steels to this mode of failure, as well as the adoption of safer stress relief procedures.
Substitution by phosphorus ligands on edge-double-bridged triruthenium carbonyl complexes and on Ru2[.mu.-O:C(Et)]2(CO)6: carbon-13 NMR characterization (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstitution by phosphorus ligands on edge-double-bridged triruthenium carbonyl complexes and on Ru2[.mu.-O:C(Et)]2(CO)6: carbon-13 NMR characterizationCarsten E. Kampe and Herbert D. KaeszCite this: Inorg. Chem. 1984, 23, 26, 4646–4653Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/ic00194a046https://doi.org/10.1021/ic00194a046research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology (2009)

1,25(OH)2D3 decreases parathyroid hormone (PTH) gene transcription through the vitamin D receptor (VDR). Total body VDR(-/-) mice have high PTH levels, hypocalcemia, hypophosphatemia, and bone malformations. To investigate PTH regulation by the VDR specifically in the parathyroid, we generated parathyroid-specific VDR knockout mice (PT-VDR(-/-)). In both strains, there was a decrease in parathyroid calcium receptor (CaR) levels. The number of proliferating parathyroid cells was increased in the VDR(-/-) mice but not in the PT-VDR(-/-) mice. Serum PTH levels were moderately but significantly increased in the PT-VDR(-/-) mice with normal serum calcium levels. The sensitivity of the parathyroid glands of the PT-VDR(-/-) mice to calcium was intact as measured by serum PTH levels after changes in serum calcium. This indicates that the reduced CaR in the PT-VDR(-/-) mice enables a physiologic response to serum calcium. Serum C-terminal collagen crosslinks, a marker of bone resorption, were increased in the PT-VDR(-/-) mice with no change in the bone formation marker, serum osteocalcin, consistent with a resorptive effect due to the increased serum PTH levels in the PT-VDR(-/-) mice. Therefore, deletion of the VDR specifically in the parathyroid decreases parathyroid CaR expression and only moderately increases basal PTH levels, suggesting that the VDR has a limited role in parathyroid physiology.
Poverty, Old-Age and Social Pensions in Kenya (2006)

Poverty, Social pensions, Kenya
Ethambutol MICs and MBCs for Mycobacterium avium complex and Mycobacterium tuberculosis (1986)

We determined the MICs of ethambutol for both Mycobacterium avium and Mycobacterium tuberculosis strains by using broth dilution (7H12 broth, radiometric method) and agar dilution (7H11 agar) methods. We found the MICs to be much lower in liquid than in solid medium. The broth-determined MICs for susceptible M. tuberculosis and most of the M. avium strains were comparable to the levels in blood of patients, being lower than the peak levels. We propose that the MICs, determined radiometrically in in 7H12 broth, be considered as tentative criteria for susceptibility testing of M. avium isolates in future clinical trials. The use of these values instead of critical concentrations should also be considered as an alternative to the conventional susceptibility testing method in chemotherapy of tuberculosis. Ethambutol produced bactericidal effects against both M. tuberculosis and M. avium, and the MIC/MBC ratios were in the same range for both species when MICs and MBCs were tested in 7H12 broth by conventional sampling and plating.
Effects of vasopressin on electrolyte transport across isolated colon from normal and dexamethasone‐treated rats. (1984)

Vasopressin enhanced the absorption of Na+ and Cl- across the short-circuited colon descendens from normal rats. This effect of vasopressin results from an increase in the mucosal to serosal movement of Na+ and Cl- and a decrease in the serosal to mucosal movement of Cl- and was accompanied with a decrease in the short-circuit current (ISC). Neither the base-line absorption of Na+ and Cl-, the vasopressin-induced increase in Na+ and Cl- absorption nor the decrease in ISC were inhibited by amiloride in the colon from normal rats. Colon descendens from rats treated for 3 days with dexamethasone had remarkably higher transmural potential difference (p.d.), tissue conductance (Gt) and ISC. The absorption of Na+ across the short-circuited colon descendens from dexamethasone-treated rats was increased 3-fold when compared to colon from normal rats. The absorption of Cl- in normal rats was reversed to Cl- secretion in treated rats. Amiloride rapidly and reversibly decreased the p.d., Gt and ISC in colon from dexamethasone-treated rats. The transport of Na+ was nearly completely inhibited by amiloride in treated rats. In contrast to its enhancing effects on Na+ absorption in colon from normal rats vasopressin did not enhance Na+ absorption in colon from dexamethasone-treated rats. This enhancement of Cl- absorption by vasopressin was retained in colon from treated rats. This enhancement of Cl- transport was due solely to a decrease in the serosal to mucosal movement of Cl- and was accompanied with a decrease in ISC and Gt. The results support the hypothesis that vasopressin causes inhibition of the electrogenic secretion of Cl- in colon from dexamethasone-treated rats. Furthermore, the results suggest that the increase in the mucosal to serosal movement of Na+ and Cl- and the decrease in the serosal to mucosal movement of Cl- in colon from normal rats are caused by independent effects of vasopressin.
Cmos versus SiGe BiCMOS: historical technology bipolarization of silicon integrated transceivers (2005)

Part of the challenge, when issuing transceiver chips for the telecommunication market today, is not only to make a consistent choice between a set standards, but also to choose the adequate technology. Depending on the standards characteristics and the proposed architecture the choice can lead either to system on chip or to system on module solutions.
Rearrangements of substituted 3‐azidoazetidines: Unexpected formation of a substituted oxazole (1995)

Abstract Thermolysis of neat N ‐carboethoxy‐3‐azido‐3‐ethylazetidine ( 3 ) at 200° under argon produced the corresponding cyclic imine 4 (68% yield). Prolonged refluxing of a mixture of N ‐triflylazetidin‐3‐one ( 7 ), sodium azide, and titanium tetrachloride in acetonitrile solvent afforded recovered 7 (25% yield) along with a colorless microcrystalline solid, 8 , mp 104–105° (20% yield), whose structure was established unequivocally via application of X‐ray crystallographic methods.
Temperature zonation of lead-zinc mineralization in Tetyukhe ore field (1966)

Abstract Quality of galena-sphalerite ores in polymetallic skarns of Tetyukhe is related to vertical and regionally geographical ( SW to NE) zonations of ore-forming temperatures, as indicated by decrepitation temperatures of inclusions in the minerals. — V. P. Sokoloff
Left Ventricle as a Mixing Chamber (1960)

It is generally assumed that blood is completely mixed while passing through a ventricular chamber. This assumption underlies use of indicator dilution technics for estimation of ventricular volume. In the left ventricle of the exposed canine heart, complete mixing of blood and injected saline during one cycle was rare, especially if the heart rate was in the normal range. Computations of absolute ventricular volume are subject to error if they are based on the assumption that indicator injected into the ventricular cavity becomes uniformly dispersed throughout the ventricular cavity before the end of diastole.
RIGHT HEART ENLARGEMENT IN COMPETITIVE ENDURANCE ATHLETES (1984)

Vos, Marc; Dressendorfer, Rudolph H. FACSM; Hauser, Andrew M.; Dudlets, Patricia; Hashimoto, Tetsuo; Timmis, Gerald C. Author Information
Degradation of Mcl-1 by β-TrCP Mediates Glycogen Synthase Kinase 3-Induced Tumor Suppression and Chemosensitization (2007)

Apoptosis is critical for embryonic development, tissue homeostasis, and tumorigenesis and is determined largely by the Bcl-2 family of antiapoptotic and prosurvival regulators. Here, we report that glycogen synthase kinase 3 (GSK-3) was required for Mcl-1 degradation, and we identified a novel mechanism for proteasome-mediated Mcl-1 turnover in which GSK-3beta associates with and phosphorylates Mcl-1 at one consensus motif ((155)STDG(159)SLPS(163)T; phosphorylation sites are in italics), which will lead to the association of Mcl-1 with the E3 ligase beta-TrCP, and beta-TrCP then facilitates the ubiquitination and degradation of phosphorylated Mcl-1. A variant of Mcl-1 (Mcl-1-3A), which abolishes the phosphorylations by GSK-3beta and then cannot be ubiquitinated by beta-TrCP, is much more stable than wild-type Mcl-1 and able to block the proapoptotic function of GSK-3beta and enhance chemoresistance. Our results indicate that the turnover of Mcl-1 by beta-TrCP is an essential mechanism for GSK-3beta-induced apoptosis and contributes to GSK-3beta-mediated tumor suppression and chemosensitization.
Cloning and characterization of cDNA for carp matrix metalloproteinase 9 (2002)

We have cloned a cDNA encoding the MMP-9 from a carp epidermal cell (EPC) cDNA library. The clone contains a 2025-base pair (bp) open reading frame encoding a protein of 674 amino acids. The deduced amino acid sequence shares 68% and 69% identity with medaka and Japanese flounder MMP-9. The hinge domain of the carp MMP-9, like those of the other non-mammalian species, lacks a type V collagen-like region that is typical of mammalian MMP-9. Gelatin zymography and immunoblot analysis of conditioned media of EPC cells and cDNA-transfected COS-7 cells detected a 76-kDa gelatinase. The apparent molecular mass of the carp zymogen is much smaller than those of its mammalian counterparts while almost identical with that of chicken 75-kDa gelatinase B-like enzyme. Although hypo-osmotic stress induced the elevation of MMP-9 mRNA level in EPC cells, no significant change in the protein in conditioned medium was detected during hypo-osmotic stress. Northern blot analysis detected a large amount of MMP-9 mRNA in carp kidney and spleen, suggesting the high expression of MMP-9 in blood cells, neutrophils, and macrophages. The smaller amount of MMP-9 mRNA was detected in gill, heart, fin, and eye, whereas none of the mRNA was detected in the hepatopancreas, intestine, brain, muscle, and skin.
Hanford low-level waste process chemistry testing data package (1996)

Recently, the Tri-Party Agreement (TPA) among the State of Washington Department of Ecology, U.S. Department of Energy (DOE) and the US Environmental Protection Agency (EPA) for the cleanup of the Hanford Site was renegotiated. The revised agreement specifies vitrification as the encapsulation technology for low level waste (LLW). A demonstration, testing, and evaluation program underway at Westinghouse Hanford Company to identify the best overall melter-system technology available for vitrification of Hanford Site LLW to meet the TPA milestones. Phase I is a {open_quotes}proof of principle{close_quotes} test to demonstrate that a melter system can process a simulated highly alkaline, high nitrate/nitrite content aqueous LLW feed into a glass product of consistent quality. Seven melter vendors were selected for the Phase I evaluation: joule-heated melters from GTS Duratek, Incorporated (GDI); Envitco, Incorporated (EVI); Penberthy Electomelt, Incorporated (PEI); and Vectra Technologies, Incorporated (VTI); a gas-fired cyclone burner from Babcock & Wilcox (BCW); a plasma torch-fired, cupola furnace from Westinghouse Science and Technology Center (WSTC); and an electric arc furnace with top-entering vertical carbon electrodes from the U.S. Bureau of Mines (USBM).