gebhart/patrepeval huggingface dataset:
The Epstein-Barr virus in the pathogenesis of posttransplant lymphoproliferative disorders. Clinical, pathologic, and virologic correlation. (1981)

Twelve renal transplant patients with lymphoproliferative disorders (LPDs) were studied. Two clinical patterns were identified: (1) Young patients present with an infectious mononucleosis-like illness with fever, sore throat, and lymphadenopathy soon after transplantation or antirejection therapy. Many organs are ultimately involved, and the clinical course is one of a rapidly fatal LPD. (2) Older patients present a longer time after transplantation with symptoms of solid tumors involving the central nervous system, oropharynx, liver, or small bowel. The clinical course is slower, but it is progressive and fatal. Morphologically these LPDs can all be classified as polymorphic diffuse B-cell hyperplasia (PDBH) or polymorphic diffuse B-cell lymphoma (PBL). Cell marker studies in four patients demonstrated a polyclonal B-cell proliferation. Transition from a polyclonal B-cell proliferation to a monoclonal tumor may occur. Epstein-Barr virus (EBV) specific antibody titers, anticomplement immunofluorescence staining of tumors for the presence of the Epstein-Barr nuclear antigen (EBNA), and EBV complementary ribonucleic acid (cRNA)/deoxyribonucleic acid (DNA) hybridization and vDNA/DNA reassociation analysis implicate EBV as the probable etiologic agent in these disorders. Successful management of these lethal LPDs may depend on discontinuation of immunosuppression and removal of the allograft. Antiviral therapy, however, may prove to be useful.
Electrosynthesis of heteroatom-heteroatom bonds. 4. Direct cross-coupling of dialkyl (or diaryl) phosphites with disulfides by a sodium bromide promoted electrolytic procedure (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrosynthesis of heteroatom-heteroatom bonds. 4. Direct cross-coupling of dialkyl (or diaryl) phosphites with disulfides by a sodium bromide promoted electrolytic procedureSigeru Torii, Hideo Tanaka, and Noboru SayoCite this: J. Org. Chem. 1979, 44, 16, 2938–2941Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/jo01330a025https://doi.org/10.1021/jo01330a025research-articleACS PublicationsRequest reuse permissionsArticle Views582Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Factors governing the Toxicity of Cultures containing the Phytoflagellate Prymnesium parvum Carter (1953)

Methods for the laboratory maintenance and purification of cultures of Prymnesium parvum are detailed. The upper limit of temperature for the growth of the organism is 30°. Light exerts an augmenting effect on the production of the toxin by Pr. parvum. Rapid and economical procedures for the bioassay of the toxin are based on the use of Gambusia minnows or tadpoles. Cell-free centrifugates of the cultures contain heat-labile toxic material which is non-diffusible through cellophan, sensitive to oxidizing agents, and reversibly inactivated by mild acidity. The toxin is rapidly inactivated by ubiquitous bacterial species (Bacillus subtilis and Proteus vulgaris). Charcoals, clays and calcium sulphate are efficient adsorbents of the toxic material. The concentration levels of toxin in cultures of Prymnesium parvum appear to reflect a dynamic equilibrium between toxin destruction and production; a similar equilibrium may prevail in nature.
A Broadband Balun Using Metamaterial Phase-Shifting Lines (2005)

A 3-port device that converts a single-ended input to a differential output over a large bandwidth is presented. The balun comprises a Wilkinson divider, followed by a +90/spl deg/ negative-refractive-index (NRI) metamaterial (MM) phase-shifting line along the top branch and a -90/spl deg/ NRI-MM phase-shifting line along the bottom branch. By independently adjusting the parameters of the two MM lines, the slopes of their phase responses can be matched and therefore a broadband differential output signal is achieved. In addition, the MM balun is compact, occupying only a fraction of the area that a conventional TL balun would occupy.
Feeding behaviour, digestive physiology and lipid content in macropterous females of <i>Pyrrhocoris apterus</i> (L.) (Heteroptera: Pyrrhocoridae) (1998)

Abstract. Macropterous females of Pyrrhocoris apterus (L.) reared under short‐day conditions (LD 12:12 h) were analysed for temporal patterns of feeding and drinking behaviour, activities of digestive enzymes in the gut, and lipid and glycogen content in the haemolymph and fat body. Peaks of drinking activity were recorded at days 3, 7 and 10 during the first 14 days after imaginal ecdysis. Feeding activity peaked on the third day, ceasing completely after the fourth day of adult life. Esterase, protease, amylase and aminopeptidase activities exhibited the highest overall activity in the first days after imaginal emergence; then enzyme activities decreased. In the fat body, the content of lipids was highest on day 5, then a decrease of about 40% was observed at day 14; the amount of glycogen was highest on day 1 at 11 μg of glucose equivalents/mg of fat body, then decreased to 2 μg at day 14 after the imaginal moult. In the haemolymph, the lipid content rose until day 8 when it reached almost 0.3 μmol/μl; at day 14 the value was slightly lower. The association of fasting with reproductive arrest in macropterous females of P. apterus , accompanied by a decrease in digestive enzyme activities and a mobilization of lipid reserves from the fat body, was demonstrated.
Elucidation of the Deposition Processes and Spatial Structures of Alkanethiol and Arylthiol Molecules Adsorbed on Pt(111) Electrodes with in Situ Scanning Tunneling Microscopy (2004)

In situ scanning tunneling microscopy (STM) was used to examine the spatial structures of n-alkane thiols (1-hexanethiol, 1-nonanethiol, and 1-octahexanethiol) and arylthiols (benzenethiol and 4-hydroxybenzenethiol) adsorbed on well-ordered Pt111 electrodes in 0.1 M HClO4. The electrochemical potential and molecular flux were found to be the dominant factors in determining the growth mechanisms, final coverages, and spatial structures of these organic adlayers. Depending on the concentrations of the thiols, deposition of self-assembled monolayers (SAMs) followed either the nucleation-and-growth mechanism or the random fill-in mechanism. Low and high thiol concentrations respectively produced two ordered structures, (2 x 2) and (square root of 3 x square root of 3)R30 degrees , between 0.05 and 0.3 V. On average, an ordered domain spanned 500 A when the SAMs were made at 0.15 V, but this dimension shrank substantially once the potential was raised above 0.3 V. This potential-induced order-to-disorder phase transition resulted from a continuous deposition of thiols, preferentially at domain boundaries of (square root of 3 x square root of 3 x )R30 degrees arrays. All molecular adlayers were completely disordered by 0.6 V, and this restructuring event was irreversible with potential modulation. Since all thiols were arranged in a manner similar to that adopted by sulfur adatoms (Sung et al. J. Am. Chem. Soc. 1997, 119, 194), it is likely that they were adsorbed mainly through their sulfur headgroups in a tilted configuration, irrespective of the coverage. Both the sulfur and phenyl groups of benzenethiol admolecules gave rise to features with different corrugation heights in the molecular-resolution STM images. All thiols were adsorbed strongly enough that they remained intact at a potential as negative as -1.0 V in 0.1 M KOH.
An Under-Actuated 5-DOF Robotic Manipulator for Ultrasound Transducer Guidance Using a Passive Four-Bar Linkage (2009)

Robotic devices have made inroads in various areas of medical practice. This paper offers a design of robot kinematics for ultrasound probe manipulation to obtain reproducible Achilles tendon images for quantifying injury or response to treatment. The design includes a motor-controlled 4-DOF arm with an additional smaller, passive four-bar linkage mount for the ultrasound probe to optimize surface contact with the subject and increase the mobility to 5 DOF.
33rd Congress of the Czech Society of Nephrology (2010)

In this study, we compared the activity of interleukin-6 (IL-6), a marker of ongoing peritoneal inflammation and biocompatibility, and its other signaling components, the soluble IL-6 receptor (sIL-6R) and soluble Gp130 (sGp130), in peritoneal effluent from patients treated with icodextrin-based (E) peritoneal dialysis (PD) solution and glucose-based bicarbonate/lactate–buffered (P) solution.
Reaction of Deuterium with Hydrocarbons Over a Cobalt—Thoria Fischer—Tropsch Catalyst<sup>1</sup> (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of Deuterium with Hydrocarbons Over a Cobalt—Thoria Fischer—Tropsch Catalyst1Sydney O. Thompson, John Turkevich, and Adolph P. IrsaCite this: J. Am. Chem. Soc. 1951, 73, 11, 5213–5215Publication Date (Print):November 1, 1951Publication History Published online1 May 2002Published inissue 1 November 1951https://pubs.acs.org/doi/10.1021/ja01155a062https://doi.org/10.1021/ja01155a062research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The barley stripe mosaic virus 58-kilodalton beta(b) protein is a multifunctional RNA binding protein (1997)

The barley stripe mosaic virus (BSMV) beta(b) gene product is the major viral nonstructural protein synthesized during early stages of the infection cycle and is required for systemic movement of the virus. To examine the biochemical properties of beta(b), a histidine tag was engineered at the amino terminus and the protein was purified from BSMV-infected barley tissue by metal affinity chromatography. The beta(b) protein bound ATPs in vitro, with a preference for ATP over dATP, and also exhibited ATPase activity. In addition, beta(b) bound RNA without detectable sequence specificity. However, binding was selective, as the beta(b) protein had a strong affinity for both single-stranded (ss) and double-stranded (ds) RNAs but not for tRNA or DNA substrates. Mutational analyses of beta(b) purified from Escherichia coli indicated that the protein has multiple RNA binding sites. These sites appear to contribute differently, because mutants that were altered in their binding affinities for ss and ds RNA substrates were recovered.
Model studies of the biosynthesis of non-head-to-tail terpenes. Stereochemistry of ionization for N-methyl-4-[(1S,1'R,3'R)-[1-2H]chrysanthemyloxy]pyridinium iodide (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModel studies of the biosynthesis of non-head-to-tail terpenes. Stereochemistry of ionization for N-methyl-4-[(1S,1'R,3'R)-[1-2H]chrysanthemyloxy]pyridinium iodideC. Dale Poulter and John M. HughesCite this: J. Am. Chem. Soc. 1977, 99, 11, 3824–3829Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://pubs.acs.org/doi/10.1021/ja00453a051https://doi.org/10.1021/ja00453a051research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Transmission and reflection characteristics of viscoelastic plates (1978)

An acoustic transmission matrix program for computing transmission (S) and reflection (R) coefficients for sound waves of arbitrary frequency, incident at arbitrary angles upon viscoelastic plates bounded by semi-infinite fluids, has been developed. The method, an extension of the formulation of Young for elastic plates, utilizes the elastic and viscoelastic material properties of plates and the program is applied here to the problem of choosing materials for acoustic windows and acoustic lenses. The materials considered are Absonic-A, polyethylene and syntactic foam. Computed results are given in the form of transmission and reflection loss and presented as functions of incidence angle and frequency, and are interpreted in terms of the propagation and material constants and modal and half wave plate resonances.
Theoretical Studies on the Deacylation Step of Serine Protease Catalysis in the Gas Phase, in Solution, and in Elastase (2004)

The deacylation step of serine protease catalysis is studied using DFT and ab initio QM/MM calculations combined with MD/umbrella sampling calculations. Free energies of the entire reaction are calculated in the gas phase, in a continuum solvent, and in the enzyme elastase. The calculations show that a concerted mechanism in the gas phase is replaced by a stepwise mechanism when solvent effects or an acetate ion are added to the reference system, with the tetrahedral intermediate being a shallow minimum on the free energy surface. In the enzyme, the tetrahedral intermediate is a relatively stable species ( approximately 7 kcal/mol lower in energy than the transition state), mainly due to the electrostatic effects of the oxyanion hole and Asp102. It is formed in the first step of the reaction, as a result of a proton transfer from the nucleophilic water to His57 and of an attack of the remaining hydroxyl on the ester carbonyl. This is the rate-determining step of the reaction, which requires approximately 22 kcal/mol for activation, approximately 5 kcal/mol less than the reference reaction in water. In the second stage of the reaction, only small energy barriers are detected to facilitate the proton transfer from His57 to Ser195 and the breakdown of the tetrahedral intermediate. Those are attributed mainly to a movement of Ser195 and to a rotation of the His57 side chain. During the rotation, the imidazolium ion is stabilized by a strong H-bond with Asp102, and the C(epsilon)(1)-H...O H-bond with Ser214 is replaced by one with Thr213, suggesting that a "ring-flip mechanism" is not necessary as a driving force for the reaction. The movements of His57 and Ser195 are highly correlated with rearrangements of the binding site, suggesting that product release may be implicated in the deacylation process.
Transcranial magnetic stimulation-based methods in the treatment of depression (2012)

sUMMArY A substantial proportion of patients fail to respond to standard treatments for depression. Several new methods of stimulating the brain are being developed as alternative interventions for these and other patient groups. Repetitive transcranial magnetic stimulation is a method of brain stimulation that involves the application of repeated magnetic pulses to directly activate cortical neurones. Several studies show it has antidepressant efficacy. There are few adverse effects of repetitive transcranial magnetic stimulation. However, the optimal stimulation parameters are not yet fully established.
Synthesis of Regioisomeric Functionalized Benzodifurans and Angelicins (2009)

Abstract Arenofurans have important biological and pharmacological activities. Compared to benzofurans, the reports on the synthesis of benzodifurans are rather limited. Here, we report the synthesis of a linear and an angular 3,3′‐bis(carboxymethyl)substituted benzodifuran and 4′‐carboxymethyl‐substituted angelicins from phloroglucinol, using 4‐halomethyl‐substituted dipyrones as key intermediates in the synthetic route. This strategy shows that the stability of a pyrone ring depends on the type of substituent at C(4) and the conditions used.
A novel whole-blood miRNA signature for a rapid diagnosis of pulmonary tuberculosis (2015)

One essential aspect for controlling the spread of tuberculosis (TB) is to diagnose it in an early stage. However, the commonly used test systems are still insufficient. Moreover, current assays perform poorly in discriminating between active TB and latent tuberculosis infection (LTBI). Due to limited knowledge of promising TB biomarkers, global “omics” approaches bear attractive options to follow [1]. MiRNAs are important post-transcriptional regulators shown to be involved in the modulation of immune responses against intracellular pathogens [2]. These findings open the possibility of using miRNAs as TB biomarkers for diagnosis. In the present study, we have investigated their role as blood biomarkers for detecting active TB. A novel, whole-blood miRNA signature enables to rapidly diagnose TB with 91.21% sensitivity and 87.95% specificity <http://ow.ly/FVvHt> Andreas Meyerhans and Irene Latorre were supported by Ministerio de Economía y Competitividad (SAF2010–21336) and ERS/SEPAR-fellowship (LTRF 82-2012), respectively. Jose Domínguez is a researcher from the Miguel Servet programme. Irene Latorre, Jose Domínguez, Maria Luiza de Souza-Galvão, Juan Ruiz-Manzano, Jose Maldonado, Cristina Prat and Andreas Meyerhans are TB-NET members.
Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential (2003)

Oxidative stress is implicated, either directly or indirectly, in the pathology of a range of human diseases. As a consequence, the development of efficient antioxidants for medical use has become increasingly important. We have synthesised a range of structurally related organo-sulfur, -selenium and -tellurium agents and demonstrated that a combination of electrochemical methodology, in vitro assays and cell culture tests can be used to rationalise the antioxidant activity of these catalytic agents. Based on its exceptionally low anodic oxidation potential (Epa) and high activity against the representative oxidative stressors tert-butyl hydroperoxide and peroxynitrite, 4,4'-dihydroxydiphenyltelluride is predicted to be a potent antioxidant. This compound exhibits a correspondingly high activity with a remarkably low IC50 value of 20 nM, when tested in PC12 cell culture using a bioassay indicative of the early stages of Alzheimer's disease.
Implementation of the AIMP D and E telemetry encoding system employing MOSFETS (1966)

Fabrication, testing, and implementation of metal oxide field effect transistors in Anchored Interplanetary Monitoring Platform D and E telemetry encoder
High-Stiffness Distal Fixation Restores Anterior Laxity and Stiffness as Well as Joint Line Fixation with an Interference Screw (2007)

The stiffness provided by each method of fixation should be considered along with the length of the graft when determining anterior laxity and knee stiffness.
Salt-stable interaction of the amino-terminal head region of vimentin with the α-helical rod domain of cytoplasmic intermediate filament proteins and its relevance to protofilament structure and filament formation and stability (1992)

Previous studies have shown that the non-alpha-helical, amino-terminal head region of vimentin is essential for the formation and stability of vimentin intermediate filaments (IFs). In order to specify its target site on companion protein subunits, it was cut off from vimentin at amino acid position 96 with lysine-specific endoproteinase and allowed to react with intact vimentin and other IF proteins. In solution of high salt concentration (500 mM KCl), the isolated polypeptide (vim NT) showed a high affinity for all cytoplasmic IF proteins tested, but not for nuclear lamins. Employing limited digestion of the IF proteins with different proteinases, the binding site was shown to reside in their alpha-helical rod domains. Other polypeptides possessing alpha-helical regions with the potential to form coiled-coil structures like tropomyosin and myosin subfragment 2 did not react with vim NT. The binding to IF proteins was strongly inhibited by phosphorylation of vim NT and totally abolished in the presence of 200 mM arginine hydrochloride, whereas the same concentration of lysine hydrochloride was ineffective. Limited chymotryptic digestion of vim NT produced polypeptides that were unable to react with the alpha-helical region of vimentin at high salt concentration. Consistent with these observations, vim NT strongly inhibited filament formation in vitro from protofilamentous vimentin. A 14-mer oligopeptide comprising the amino acids 3 to 16 of the amino terminus also inhibited filament formation, though to a lesser extent. Conversely, vim NT and, with a lower efficiency, the 14-mer oligopeptide also severely affected the structure of preformed vimentin filaments by unraveling them. Phosphorylated vim NT was considerably less active in this respect. Further digestion of the rod domain of vimentin with chymotrypsin yielded 17.4 and 21 kDa polypeptides, which were tentatively characterized as originating from the carboxy- and amino-terminal half of the rod domain, respectively. Both formed salt-stable complexes with vim NT, the smaller polypeptide with a higher efficiency than the larger one. These results suggest that the staggered, antiparallel arrangement of the two coiled-coils in the protofilaments of IF proteins is, at least in part, determined by the twofold, symmetrical association of the amino-terminal head regions of one coiled-coil rope structure with the carboxy-terminal halves of the alpha-helical rod domains of the other coiled-coil and that similar interactions occur during filament assembly and in the intact filament.