gebhart/patrepeval huggingface dataset:
Short communication. SNP [single nucleotide polymorphism] analyses of the 5HT1R [5-hydroxytryptamine receptor1] and STAT [signal transducer and activator of transcription] genes in Pacific white shrimp, Litopenaeus vannamei (2010)

Shrimp aquaculture is one of the growing animal industries. Breeding stocks with high disease-resistance and growth rate are of particular interest to shrimp breeders. Association studies are useful to find genetic markers for marker assisted selection of animals. Using six Litopenaeus vannamei individuals from a sample population, four single nucleotide polymorphisms (SNPs) were found in the 5HT1R (5-hydroxytryptamine receptor1) gene and one SNP in the STAT (signal transducer and activator of transcription) gene. However, the SNP in the STAT gene was homozygous in a different population used for association analyses. The association analyses revealed that allele C of two SNPs, C109T and C395G in 5HT1R, tended to be associated with increased body weight. Further studies need to be conducted using a large and diverse population sample.
Design tradeoffs for the Alpha EV8 conditional branch predictor (2002)

This paper presents the Alpha EV8 conditional branch predictor The Alpha EV8 microprocessor project, canceled in June 2001 in a late phase of development, envisioned an aggressive 8-wide issue out-of-order superscalar microarchitecture featuring a very deep pipeline and simultaneous multithreading. Performance of such a processor is highly dependent on the accuracy of its branch predictor and consequently a very large silicon area was devoted to branch prediction on EV8. The Alpha EV8 branch predictor relies on global history and features a total of 352 Kbits.The focus of this paper is on the different trade-offs performed to overcome various implementation constraints for the EV8 branch predictor. One such instance is the pipelining of the predictor on two cycles to facilitate the prediction of up to 16 branches per cycle from any two dynamically successive, 8 instruction fetch blocks. This resulted in the use of three fetch-block old compressed branch history information for accesing the predictor. Implementation constraints also restricted the composition of the index functions for the predictor and forced the usage of only single-ported memory cells.Nevertheless, we show that the Alpha EV8 branch predictor achieves prediction accuracy in the same range as the state-of-the-art academic global history branch predictors that do not consider implementation constraints in great detail.
Antiulcerogenic Effects of Kolaviron: Inhibition of Apoptosis induced by Indomethacin in the intact Rat Stomach and Rat Gastric Mucosa Cell line (2010)

The crude extracts of the seed of Garcinia kola (GK) and its constituent biflavonoid, Kolaviron (KV), have been shown to effectively protect the stomach of rats form ulceration induced by HCl/Ethanol mixture as well as indomethacin. However, the anti-ulcerogenic mechanisms are yet to be fully elucidated. Since apoptosis has been identified as a potent factor in ulcerogenesis, the study was designed to examine the anti-apoptotic effect of KV in intact and cultured gastric cells (RGM- 1) of rat. Confluent Rat Gastric Mucosal (RGM-1) cells were challenged with medium containing 500uM indomethacin in the presence or absence of 0.5ug/ml and 5.0ug/ml KV. Cell viability was measured by the MTT [3-(4, 5– dimethylthiazol-2-yl]- 2,5-deiphenyltetrazolium bromide] assay. The effect of the treatments on the cell cycle phases was determined by flow cytometry using a Beckman-Coulter FACScan. Apoptosis was measured as the proportion of cells in the sub G0/G1 phase of the cell cycle. An assessment of the generation of reactive oxygen species (ROS) after treatments was also carried out. Treatment of cells with indomethacin decreased cell viability and was accompanied by apoptotic DNA fragmentation. Pretreatment of cells with KV significantly suppressed cell death caused by long-term indomethacin treatment. In addition, indomethacin-induced RGM-1 cell apoptosis was evidenced by an increase in the proportion of cells in the sub-G0/G1 phase from 6.93 ± 2.56% in the unexposed cells to 30.44 ± 2.56% in cells exposed to 500uM indomethacin (P < 0.001). Treatments with 0.5ug/ml and 5.0ug/ml KV reversed the apoptotic effect of indomethacin. In vivo, pre-treatment of rat with KV significantly reduced indomethacin-induced ulcer formation and total apoptotic score. These results imply that the inhibition of apoptosis may be an important mechanism via which KV protects the stomach from ulcerogenesis.
Role of the Drosophila Non-Visual ß-Arrestin Kurtz in Hedgehog Signalling (2011)

The non-visual ß-arrestins are cytosolic proteins highly conserved across species that participate in a variety of signalling events, including plasma membrane receptor degradation, recycling, and signalling, and that can also act as scaffolding for kinases such as MAPK and Akt/PI3K. In Drosophila melanogaster, there is only a single non-visual ß-arrestin, encoded by kurtz, whose function is essential for neuronal activity. We have addressed the participation of Kurtz in signalling during the development of the imaginal discs, epithelial tissues requiring the activity of the Hedgehog, Wingless, EGFR, Notch, Insulin, and TGFβ pathways. Surprisingly, we found that the complete elimination of kurtz by genetic techniques has no major consequences in imaginal cells. In contrast, the over-expression of Kurtz in the wing disc causes a phenotype identical to the loss of Hedgehog signalling and prevents the expression of Hedgehog targets in the corresponding wing discs. The mechanism by which Kurtz antagonises Hedgehog signalling is to promote Smoothened internalization and degradation in a clathrin- and proteosomal-dependent manner. Intriguingly, the effects of Kurtz on Smoothened are independent of Gprk2 activity and of the activation state of the receptor. Our results suggest fundamental differences in the molecular mechanisms regulating receptor turnover and signalling in vertebrates and invertebrates, and they could provide important insights into divergent evolution of Hedgehog signalling in these organisms.
Optimization and Reliability of a Deep Water Running Test in Healthy Adults Older than 45 Years (2010)

A 6- to 12-min protocol duration can be used to assess deep water running test peak Vo2, which is reproducible and lower compared with that obtained on the treadmill in healthy subjects older than 45 yrs.
Comments on "Speciation of airborne nickel in occupational exposures" (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComments on "Speciation of airborne nickel in occupational exposures"Vladimir J. Zatka and J. Stuart WarnerCite this: Environ. Sci. Technol. 1991, 25, 12, 2096Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/es00024a017https://doi.org/10.1021/es00024a017research-articleACS PublicationsRequest reuse permissionsArticle Views14Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Measurement system for noninvasive dynamic optical topography</title> (1999)

We have developed a 24-channel simultaneous measurement system for optical topography that noninvasively obtains dynamic images of brain activity over a measurement area of 90 mm by 90 mm. To evaluate the system performance, we utilized a phantom containing a rotating absorber in a cylindrical scattering medium. In this system, eight incident and eight detecting optical fibers are arranged alternately at points of a square lattice on the phantom. The phantom is illuminated with light of two wavelengths (780 and 830 nm) from each incident fiber. Reflected light is received by the detecting fibers, each of which is connected to an avalanche photodiode. Multiple modulation and lock-in detection are used to enable highly sensitive measurement with negligible crosstalk (less than -50 dB). In the phantom measurement, we obtained topographic dynamic images of the absorber rotating in the medium with a temporal resolution of 0.5 s.
Advances in Enzymology, 39. A. Meister, Ed., John Wiley & Sons, New York, N. Y. 10016, 1973, v + 487 pp. $22.50 (1974)

Journal Article Advances in Enzymology, 39. A. Meister, Ed., John Wiley & Sons, New York, N. Y. 10016, 1973, v + 487 pp. $22.50 Get access Morton K Schwartz Morton K Schwartz Memorial Sloan-Kettering Cancer Center New York, N. Y 10021 Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 20, Issue 5, 1 May 1974, Page 635, https://doi.org/10.1093/clinchem/20.5.635 Published: 01 May 1974
Different Structural Requirements for the Constitutive and the Agonist-induced Activities of the β2-Adrenergic Receptor (2005)

We converted Ser-207, located in helix 5 of the beta2-adrenergic receptor, into all other natural amino acids. To quantify receptor activation as a receptor number-independent parameter and directly related to G(s) activation, we expressed the mutants in a G alpha(s)-tethered form. GTP exchange in such constructs is restricted to the fused alpha-subunit and is a linear function of the receptor concentration. Except S207R, all other mutants were expressed to a suitable level for investigation. All mutations reduced the binding affinities of the catechol agonists, epinephrine and isoproterenol, and the extent of reduction was unrelated to the residue ability to form hydrogen bonds. Instead, both enhancements and reductions of affinity were observed for the partial agonist halostachin and the antagonist pindolol. The mutations also enhanced and diminished ligand-induced receptor activation, but the effects were strictly ligand-specific. Polar residues such as Asp and His exalted the activation by full agonists but suppressed that induced by the partial agonists halostachin and dichloroisoproterenol. In contrast, hydrophobic residues such as Ile and Val augmented partial agonist activation. Only Ile and Lys produced a significant increase of constitutive activity. The effects on binding and activity were not correlated, nor did such parameters show any clear correlation with up to 78 descriptors of amino acid physicochemical properties. Our data question the idea that Ser-207 is exposed to the polar crevice in the unbound receptor. They also suggest that the active receptor form induced by a full agonist might be substantially different from that caused by constitutive activation.
Effects of Pulsed—Current Discharge Waveforms on Lead—Acid Traction Cell Performance (1982)

<div class="htmlview paragraph">Chopper-type controllers commonly used in electric vehicle propulsion systems impose pulsed-current discharge conditions on the battery that influence both its internal power losses and available energy. In order to optimize propulsion system design, those discharge parameters that affect battery performance must be understood and characterized. In a series of tests performed on Exide EV-106 and EE-IV lead-acid traction batteries, a range of operating values were examined for current pulse frequency, average current discharge rate and pulse-to-average current level ratio. For each test, one parameter was selected as the variable while the other two parameters were maintained at fixed levels. Constant-current discharges were periodically performed during each test to relate battery performance for equivalent pulsed and constant current discharge conditions. The results show that battery performance was independent of current pulse frequency and battery internal power losses varied directly with both the average current discharge rate and the pulse-to-average current ratio. The amp-hour capacity obtained with pulsed-current discharges was greater than that obtained with equivalent constant-current discharges due to the increase in battery temperature produced by the higher pulsed-current internal power losses. However, with pulsed-current discharging, battery output power and available energy were always less than that obtained with equivalent constant-current discharging.</div>
Chromatographic Analysis of Phospholipids during Monocyte Maturation (1988)

Abstract Whether ether phospholipids are intrinsic to cell membranes or are acquired concomitantly with capacity for motion is unknown. Plasmalogen content was assessed in the human monocyte-macrophage-like cell line U937 that can be induced with dimethylsulfoxide (1.3%) to synchronously differentiate from poorly motile immature leukocytic cells to briskly motile mature cells. The phosphatidylethanolamine (PE) content of immature cells was 180 ± 10 μg/108 cells for U937 cells. Alkaline hydrolysis of PE resulted in 50% lyso-PE and 50% free fatty acid. Treatment of lyso-PE with acid and phospholipase A2 demonstrated that PE is 1-(0-1'-aklenyl), 2-acyl PE. This was confirmed by infrared and proton nuclear magnetic resonance ('H-NMR) spectroscopy. The phosphatidylcholine (PC) content of immature cells was 235 ± 5 μg/108 cells. In contrast to PE< 100% of PC was diacyl homologues. Following differentiation to mature motile cells, the plasmalogen content of PE and PE significantly increased. The content of PC and PE in normal motile human peripheral blood monocytes was similar. The increase of plasmalogen in the PE component and its appearance in the PC component of mature motile U937 cells may indicate that plasmalogen correlates with the acquisition of motile function.
Gapless Genome Assembly of the Potato and Tomato Early Blight Pathogen <i>Alternaria solani</i> (2018)

The Alternaria genus consists of saprophytic fungi as well as plant-pathogenic species that have significant economic impact. To date, the genomes of multiple Alternaria species have been sequenced. These studies have yielded valuable data for molecular studies on Alternaria fungi. However, most of the current Alternaria genome assemblies are highly fragmented, thereby hampering the identification of genes that are involved in causing disease. Here, we report a gapless genome assembly of A. solani, the causal agent of early blight in tomato and potato. The genome assembly is a significant step toward a better understanding of pathogenicity of A. solani.
Designing Information Systems Security (1988)

This book addresses the uses and practical aspects of the analysis, design and specification of information systems security, and will represent the intersection of the work in computer security and current work in systems analysis and auditing. Written from a management information perspective rather than from the standpoint of computer science or from the standpoint of the security consultant, the book looks at both the managerial, organizational and social implications as well as the underlying technology. The book further discusses the problems created by computer security and analyses the managerial justification of information systems controls.
<i>CFTR</i>-France, a national relational patient database for sharing genetic and phenotypic data associated with rare<i>CFTR</i>variants (2017)

Most of the 2,000 variants identified in the CFTR (cystic fibrosis transmembrane regulator) gene are rare or private. Their interpretation is hampered by the lack of available data and resources, making patient care and genetic counseling challenging. We developed a patient-based database dedicated to the annotations of rare CFTR variants in the context of their cis- and trans-allelic combinations. Based on almost 30 years of experience of CFTR testing, CFTR-France (https://cftr.iurc.montp.inserm.fr/cftr) currently compiles 16,819 variant records from 4,615 individuals with cystic fibrosis (CF) or CFTR-RD (related disorders), fetuses with ultrasound bowel anomalies, newborns awaiting clinical diagnosis, and asymptomatic compound heterozygotes. For each of the 736 different variants reported in the database, patient characteristics and genetic information (other variations in cis or in trans) have been thoroughly checked by a dedicated curator. Combining updated clinical, epidemiological, in silico, or in vitro functional data helps to the interpretation of unclassified and the reassessment of misclassified variants. This comprehensive CFTR database is now an invaluable tool for diagnostic laboratories gathering information on rare variants, especially in the context of genetic counseling, prenatal and preimplantation genetic diagnosis. CFTR-France is thus highly complementary to the international database CFTR2 focused so far on the most common CF-causing alleles.
Simulation of Earthquake Rupture Dynamics in Complex Geometries Using Coupled Finite Difference and Finite Volume Methods (2015)

Abstract We couple a node-centered finite volume method to a high order finite difference method to simulate dynamic earthquake ruptures along nonplanar faults in two dimensions. The finite volume method is implemented on an unstructured mesh, providing the ability to handle complex geometries. The geometric complexities are limited to a small portion of the overall domain and elsewhere the high order finite difference method is used, enhancing efficiency. Both the finite volume and finite difference methods are in summation-by-parts form. Interface conditions coupling the numerical solution across physical interfaces like faults, and computational ones between structured and unstructured meshes, are enforced weakly using the simultaneous-approximation-term technique. The fault interface condition, or friction law, provides a nonlinear relation between fields on the two sides of the fault, and allows for the particle velocity field to be discontinuous across it. Stability is proved by deriving energy estimates; stability, accuracy, and efficiency of the hybrid method are confirmed with several computational experiments. The capabilities of the method are demonstrated by simulating an earthquake rupture propagating along the margins of a volcanic plug.
Wraparound care for youth injured by violence: study protocol for a pilot randomised control trial (2015)

NCT01895738.
Sex modifies the association between body mass index and carotid artery intima media thickness in the multi-ethnic Singapore population (2021)

Abstract Background and aims Globally cardiovascular disease (CVD) risk is higher in men than in women in the younger age group but the risk is attenuated in later life with an unexpected higher risk in women in some populations. A better understanding of sex differences in CVD is needed. Carotid artery intima-media thickness (CIMT) has been proposed for CVD risk assessment in individuals at intermediate risk. We study the gender interactions in the associations of the traditional cardiovascular risk factors with CIMT. Methods We performed carotid ultrasonography in the large population health study-HELIOS conducted in Singapore. Measurements were performed as per Mannheim consensus, at the far wall of bilateral common carotid artery at 8 sites in each participant. We report the average of all measurements (avgCIMT) and maximum value (maxCIMT). We analysed 2061 healthy participants recruited between 2018–2020. Inclusion criteria for this analysis: non-smokers, not known to have diabetes, hypertension, hyperlipidemia or ischemic heart disease. Individuals with systolic blood pressure &gt;160 mm Hg or fasting glucose &gt;7.0 mmol/L on recruitment were excluded. Multivariable linear regression analysis was performed to examine the association between CIMT and cardiovascular risk factors in the healthy population adjusting for age, sex and ethnicity. All analysis was performed using Stata version 16.0. Results After exclusion, 1407 healthy participants were included in the analysis. Median (IQR) avgCIMT: 0.56 (0.50, 0.65) in men; 0.54 (0.50, 0.58) in women. Median (IQR) maxCIMT: 0.64 (0.57, 0.76) in men; 0.61 (0.54, 0.70) in women. The avgCIMT and the maxCIMT were higher in males when compared to women and all traditional cardiovascular risk factors associated with CIMT after adjustment for age, sex and ethnicity (P&lt;0.05) (Table 1). Interaction tests in multivariable model adjusted for age, ethnicity, pulse pressure, non HDL-C and HbA1c showed a significant interaction between sex and body mass index (BMI) with predicted effects on avgCIMT and maxCIMT being relatively higher in males at the same BMI when compared to females (P-interaction &lt;0.01) (Figure 1). Conclusion Sex modifies the relationship between BMI and CIMT in Singapore's multi-ethnic population. Understanding the intermediary mechanisms involved will help in developing personalized preventive strategies. Funding Acknowledgement Type of funding sources: None. Figure 1
Formation and Metabolism of Methylmalonyl Coenzyme A in <i>Corynebacterium glutamicum</i> (2009)

Genome sequence information suggests that B(12)-dependent mutases are present in a number of bacteria, including members of the suborder Corynebacterineae like Mycobacterium tuberculosis and Corynebacterium glutamicum. We here functionally identify a methylmalonyl coenzyme A (CoA) mutase in C. glutamicum that is retained in all of the members of the suborder Corynebacterineae and is encoded by NCgl1471, NCgl1472, and NCgl1470. In addition, we observe the presence of methylmalonate in C. glutamicum, reaching concentrations of up to 757 nmol g (dry weight)(-1) in propionate-grown cells, whereas in Escherichia coli no methylmalonate was detectable. As demonstrated with a mutase deletion mutant, the presence of methylmalonate in C. glutamicum is independent of mutase activity but possibly due to propionyl-CoA carboxylase activity. During growth on propionate, increased mutase activity has severe cellular consequences, resulting in growth arrest and excretion of succinate. The physiological context of the mutase present in members of the suborder Corynebacterineae is discussed.
Reorientational Dynamics of the Dodecahydro-<i>closo</i>-dodecaborate Anion in Cs<sub>2</sub>B<sub>12</sub>H<sub>12</sub> (2011)

Rapid reorientational motions of the B(12)H(12)(2-) icosahedral anion, a key intermediate in borohydride dehydrogenation, are revealed by quasielastic neutron scattering (QENS) measurements of Cs(2)B(12)H(12) between 430 and 530 K. At 430 K, over the range of momentum transfers collected, the elastic incoherent structure factor (EISF) is consistent with a model for reorientational jumps about a single molecular axis. At temperatures of 480 K and higher, however, the EISF suggests the emergence of multiaxis reorientation by dynamically similar, independent jumps about two axes, on average, preserving crystallographic order. Alternatively, if one assumes that the anions are undergoing temperature-dependent rotational trapping, then the EISF is also consistent with a jump model involving a temperature-dependent mobile fraction of anions statistically tumbling between discrete crystallographic sites. Although neutron vibrational spectra demonstrate that the anion torsional modes soften dramatically with increasing temperature, the QENS-derived activation energy of 333 meV for reorientation clearly shows that the anions are not undergoing isotropic rotational diffusion.