gebhart/patrepeval huggingface dataset:
Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle (2015)

Skeletal muscle mitochondrial content and oxidative capacity are important determinants of muscle function and whole-body health. Mitochondrial content and function are enhanced by endurance exercise and impaired in states or diseases where muscle function is compromised, such as myopathies, muscular dystrophies, neuromuscular diseases, and age-related muscle atrophy. Hence, elucidating the mechanisms that control muscle mitochondrial content and oxidative function can provide new insights into states and diseases that affect muscle health. In past studies, we identified Perm1 (PPARGC1- and ESRR-induced regulator, muscle 1) as a gene induced by endurance exercise in skeletal muscle, and regulating mitochondrial oxidative function in cultured myotubes. The capacity of Perm1 to regulate muscle mitochondrial content and function in vivo is not yet known. In this study, we use adeno-associated viral (AAV) vectors to increase Perm1 expression in skeletal muscles of 4-wk-old mice. Compared to control vector, AAV1-Perm1 leads to significant increases in mitochondrial content and oxidative capacity (by 40-80%). Moreover, AAV1-Perm1-transduced muscles show increased capillary density and resistance to fatigue (by 33 and 31%, respectively), without prominent changes in fiber-type composition. These findings suggest that Perm1 selectively regulates mitochondrial biogenesis and oxidative function, and implicate Perm1 in muscle adaptations that also occur in response to endurance exercise.
A New Database of Child Anthropometry and Seated Posture for Automotive Safety Applications (2005)

<div class="htmlview paragraph">This paper presents a laboratory study of body dimensions, seated posture, and seatbelt fit for children weighing from 40 to 100 lb (18 to 45 kg). Sixty-two boys and girls were measured in three vehicle seats with and without each of three belt-positioning boosters. In addition to standard anthropometric measurements, three-dimensional body landmark locations were recorded with a coordinate digitizer in sitter-selected and standardized postures. This new database quantifies the vehicle-seated postures of children and provides quantitative evidence of the effects of belt-positioning boosters on belt fit. The data will provide guidance for child restraint design, crash dummy development, and crash dummy positioning procedures.</div>
Small Business Technological Assets Protection Factors Analysis Using Logistic Regression Analysis (2015)

본 연구는 중소기업청에서 실시한 2013년 중소기업 기술보호 역량 및 수준조사를 바탕으로 중소기업의 기술유출 경험유무와 기술보호 요인을 분석하여 정부지원을 통한 기술유출방지 효과를 극대화 할 수 있는 핵심 요인을 도출하고자 한다. 중소기업 기술보호 역량 및 수준조사 대상 1,561개 기업 중 대기업 43개를 제외한 1,518개 중소기업 중 기술유출 중소기업 155개와 미유출 중소기업 1,363개 중소기업에 대해 기술보호 요인을 로지스틱 회귀분석 하였다. 기술유출 관련 요인을 분석한 결과, 출입자 통제 시스템 운영, 보안감사 실시여부, 임직원 부재 시 보안활동, 중요자료 보호대책 마련이 핵심요인으로 도출되었으며, 이들 사항에 대해 정부차원에서 집중적인 지원이 이루어진다면 기술보호 효과가 극대화 될 수 있을 것으로 사료된다. The main objective of this study was to identify the factors that can maximize the effect of preventing technology leakage by government support. Therefore we used the 2013 small business technology protection capabilities and level of research which is conducted by the Small and Medium Business Administration, and have analyzed the presence of small business technological assets leakage protection eand skills. Multiple logistic regression analysis was performed to identify 1,518 small companies (43 big companies are excluded) which are divided into 155 technological assets leaked small business and non-leaked 1363 small business. The most important factors associated with technology leakage were entrant control system, security audit, employee absence of security activities and important data protection measures. This result shows that if the government can support more for these details, technological asset leakage prevention effect is expected to be maximized.
Excess Volumes and Isentropic Compressibilities of 1,2-Dichloroethane with Ketones (1984)

Abstract Experimental data for the excess volume and the sound velocity in binary mixtures of 1,2-di-chloroethane with methyl ethyl ketone, diethyl ketone, methyl propyl ketone, methyl iso-butyl ketone, cyclopentanone, cyclohexanone and 2-methyl cyclohexanone are reported at 303.15 K. All the systems exhibited small VE and ΔKs values.
Annotated World Bibliography of Host Fruits of Bactrocera latifrons (Hendel) (Diptera: Tephritidae) (2013)

McQuate, Grant T., Liquido, Nicanor J. (2013): Annotated World Bibliography of Host Fruits of Bactrocera latifrons (Hendel) (Diptera: Tephritidae). Insecta Mundi 2013 (289): 1-61, DOI: 10.5281/zenodo.5175793
Periodic Cracks in the Neighborhood of the Interface of Two Anisotropic Bodies under Longitudinal Shear (1985)

This paper is concerned with the periodic cracks in the neighborhood of the interface of two anisotropic bodies under longitudinal shear. The analysis is based on the singular point method. Replacing the cracks with continuous distributions of screw dislocations, we obtain a singular integral equation with Cauchy kernel. Numerical results for he stress intensity factors are plotted in termes of the geometrical parameters of crack arrangement and physical properties of the anisotropic bodies.
Retarding and antioxidant activity of 1‐cyclohexylthio‐2‐mercaptobenzimidazole in the vulcanization of NR accelerated by thiocarbamyl sulfenamide (1987)

Abstract The effect of 1‐cyclohexylthio‐2‐mercaptobenzimidazole (CMB) on the vulcanization of NR accelerated by N ‐oxydiethylene thiocarbamyl‐ N ′‐oxydiethylene sulfenamide (OTOS) has been studied. It is found that CMB delays the onset of cure and generates 2‐mercaptobenzimidazole during vulcanization. The results indicate the retarding as well as antioxidant activity of CMB.
HLA-DQA1 and -DQB1 Alleles Associated With Genetic Susceptibility to IDDM in a Black Population (1991)

Transracial analysis provides a method of distinguishing primary associations between insulin-dependent diabetes mellitus (IDDM) and HLA class II alleles from those secondary to linkage disequilibrium. Blacks show DR-DQ relationships that are different from other races and are a useful group in which to investigate HLA-D region associations with IDDM. In this study, the frequencies of HLA-DQA1 and -DQB1 alleles in Afro-Caribbean IDDM and control subjects were compared. Alleles were identified with sequence-specific oligonucleotide probing. The DQA1 allele A3 was positively associated with IDDM (relative risk [RR] = 25.3, corrected P [Pc] less than 7.0 x 10(-6). The DQB1 alleles DQw2 and DQw8 were also positively associated (RR = 4.7, Pc less than 6.5 x 10(-3) and RR = 12.3, Pc = 3.4 x 10(-3), respectively). The A1.2 and DQw6 alleles were negatively associated (RR = 0.16, Pc less than 3.5 x 10(-3) and RR = 0.15, Pc = 2.4 x 10(-2), respectively). These findings were compared to data from other races. The positive associations with A3 and DQw2 are consistent with all racial groups investigated. The negative association with DQw6 is present in all racial groups in which it is a common allele. These findings suggest that DQ alleles, and hence DQ molecules, may directly affect predisposition to IDDM.
Long-Term Impact of Breast-Feeding on Body Weight and Glucose Tolerance in Children of Diabetic Mothers (2005)

Neither late neonatal DBM intake nor the duration of breast-feeding has an independent influence on childhood risk of overweight or IGT in ODM. Therefore, the 1st week of life appears to be the critical window for nutritional programming in ODM by ingestion of maternal "diabetic" breast milk.
Wide-spectrum antibiotic activity of bovine granulocyte polypeptides (1984)

The antibiotic activity of a polypeptide fraction purified from bovine granulocyte granules was tested against Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Bacillus subtilis, Bacillus stearothermophilus, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus faecalis, Streptococcus pyogenes, and clinical isolates of Staphylococcus and Enterobacter spp. All of these bacterial species were susceptible to the antibiotic polypeptide(s), with MICs ranging from 3 to 100 micrograms of protein per ml. The antimicrobial activity was resistant to boiling and abolished by proteinase treatment. Saccharomyces cerevisiae and human fibroblasts grew normally in the presence of 100 and 50 micrograms of antibiotic polypeptide(s) per ml, respectively. [3H]thymidine incorporation into bacterial, but not fibroblast, DNA was efficiently and promptly inhibited by the antimicrobial polypeptide preparation. This suggests that its main target is a component of the system, which catalyzes and regulates the biosynthesis of bacterial DNA.
Effects of impending ovarian failure induced by 4-vinylcyclohexene diepoxide on fertility in C57BL/6 female mice. (2007)

Repeated daily dosing of mice with 4-vinylcyclohexene diepoxide (VCD) causes a gradual onset of ovarian failure, providing a model for perimenopause. Because increasing numbers of women are delaying starting a family, infertility in aging women is of concern. This study was designed to determine the effects of impending ovarian failure on fertility in VCD-treated mice. Female C57BL/6J mice were dosed daily (17 d) with vehicle control or VCD (160 mg/kg, intraperitoneally) to deplete primordial follicles and then were divided into 2 groups. Group 1 was mated soon after dosing; group 2 was mated on day 20 after dosing, during impending ovarian failure. Fertility was evaluated on gestational day 16. In group 1, cycle length, pregnancy rate, and number of live fetuses did not differ between VCD-treated animals and controls, but VCD-treated mice required more matings to become pregnant and had more resorptions. In group 2, VCD-treated mice demonstrated proestrus and copulatory plugs, but only 1 animal became pregnant, and she had no viable fetuses. Ovaries from pregnant and nonpregnant controls contained similar numbers of follicles and corpora lutea. Ovaries from VCD-treated animals contained no follicles, and corpora lutea were seen only in pregnant animals. In VCD-treated mice mated soon after dosing, conception was more difficult and more resorbed fetuses were seen, whereas in those mated closer to impending ovarian failure, no successful pregnancies were achieved. These results demonstrate that VCD-treated mice can be used to model infertility in perimenopausal women.
Effects of a two-step rapid thermal annealing process on Mg-doped p-type GaN films grown by metalorganic chemical vapor deposition (2001)

A two-step rapid thermal annealing (RTA) process is proposed in order to improve the electrical properties, the crystal quality, and the surface roughness of Mg-doped p-type GaN films. In the two-step RTA process, the first low temperature step (600 °C) with a long annealing time (5 min) was followed by the second high temperature (950 °C) step with a short annealing time. These results show that the two-step RTA process significantly improves electrical properties and reduces the surface roughness of p-GaN compared to the one-step RTA process.
Anthropomorphic awareness of partner robot to user's situation based on gaze and speech detection (2012)

This paper introduces a daily-partner robot, that is aware of the user’s situation by using gaze and utterance detection. For appropriate anthropomorphic interaction, the robot should talk to the user in proper timing without interrupting her/his task. Our proposed robot 1) estimates the user’s context (the target of her/his speech) by detecting his/his gaze the utterance, 2) expresses the need to speak to the user by silent gaze-turns towards the user and the object of joint attention (speech-implying behaviour) and 3) tells the message when the user talks to the robot. Based on preliminary results that show the sufficient human-sensitivity to the speech-implying behaviours of the robot, we evaluate the proposed behavioural model. The results show that the crossmodal awareness is effective for respectful communication that does not disturb the user’s ongoing task by silent behaviours that effectively show the robot’s intention to speak and draw the user’s attention.
Spread-spectrum optical fibre network based on pulsed coherent correlation (1990)

Coherent recombination of a series of pulses derived from a single laser pulse by matched filtering, using optical ladder networks is shown to result in a highly single-peaked correlation function. The technique may be used in a local area network based on a star topology when this coherent correlation is generated using a low coherence source. This provides a more practical but equally powerful alternative to other current proposals.
Sympathetic Responses to Stress and Rilmenidine in 2K1C Rabbits (2004)

We determined whether the sympathetic excitatory responses to environmental stressors and the sympathoinhibitory responses to rilmenidine are altered by renovascular hypertension. Rabbits were made hypertensive with a clip on the right renal artery, and a left renal nerve recording electrode was implanted. After 3 or 6 weeks, the animals were given air-jet stress and loud noise stress before and after intravenous rilmenidine. Three and 6 weeks after renal clipping, mean arterial pressure was 28% and 36% greater than preclip values. Air-jet stress elicited a marked increase in renal sympathetic nerve activity, mean arterial pressure, and heart rate. Renal sympathetic nerve activity responses were much greater in hypertensive rabbits, but the pressor responses were similar to those observed in normotensive animals. Acute administration of rilmenidine decreased blood pressure more in hypertensive animals but with a much lesser inhibition of sympathetic activity. Rilmenidine markedly reduced increased sympathetic activity during air-jet stress in 3-week clipped rabbits but to a lesser extent in the other groups. These studies show that while sympathetic responses to stress were markedly enhanced in renal clip hypertensive rabbits, they did not result in greater pressor responses, thus suggesting that vascular neuroeffector mechanisms were not altered. By contrast, the increased effects of rilmenidine suggest a much greater contribution to the hypertension by the sympathetic nervous system, but one that is caused by an enhanced "nonvascular" neuroeffector mechanism. As such, sympathoinhibitory agents such as rilmenidine are very suitable and very effective agents for the treatment of renovascular hypertension.
Phase diagram of γ-butyrolactone-dimethyl-carbonate mixtures (2001)

Using differential scanning calorimetry (DSc) and X-ray diffraction (XRD) at low temperatures we have determined a phase relation between y-butyrolactone and dimethyl carbonate. Two polymorphs of ybutyrolactone with a monotropic transformation and two polymorphs of dimethyl carbonate with an enantiotropic transformation induced by BL were observed. The diagram is characterised by an eutectic point for xDMC=O. 12 and T=-.57.5OC.
Hematological monitoring during therapy with carbamazepine in children (1983)

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Isolation of multidrug-resistant Salmonella in Singapore (2015)

Multidrug-resistant Salmonella is a well-recognised problem worldwide, especially in developing countries such as India, where non-typhoidal Salmonella infections and enteric fever are endemic. Antimicrobial resistance, particularly to fluoroquinolones, is common and leads to the frequent use of alternative agents, such as azithromycin. We herein describe the first reported case of azithromycin-resistant Salmonella gastroenteritis in a Singaporean patient.
Decay channels of core-excited HCl (1990)

The HCl 2${\mathit{p}}_{\mathrm{Cl}}$\ensuremath{\rightarrow}${\mathrm{\ensuremath{\sigma}}}^{\mathrm{*}}$ photoexcitation resonance has been studied using a tunable synchrotron radiation beam with a narrow bandwidth. Extensive ab initio molecular and atomic calculations have been carried out to analyze the details of the measured electron spectra. The interatomic potential-energy curves have been calculated for the ground and selected excited states of HCl using the complete-active-space self-consistent-field method. Multiconfiguration Dirac-Fock energies and line intensities of the atomic chlorine Auger spectrum have been used to identify the intense atomic spectral lines in the measured electron spectrum. Comparison between theory and experiment indicates fast neutral dissociation of the excited HCl molecules, followed by resonance Auger processes of the core-excited chlorine atoms. The atomic spectral lines are found to overlap with a strong background of broad structures, which sum up to 40% of the total intensity. This contribution has been addressed to the 2.9-eV potential well in our potential-energy curve of the excited HCl allowing for Franck-Condon transitions to bound vibrational states with a molecular nonradiative decay mode.
Non-stationary Gaussian spatio-temporal modeling of fMRI data (2005)

In functional magnetic resonance imaging (fMRI), modeling of the complex link between neuronal activity and its hemodynamic expression via the neurovascular coupling usually requires the use of elaborated models. To avoid linear assumptions and a priori modeling of this expected hemodynamic signal, Bayesian approaches have recently improved their accuracy in estimating and detecting brain activation. Recent studies, using Markov random field (MRF) to represent activated brain voxels and likelihoods to find the maximum a posteriori (MAP) estimation of model parameters, provided superior efficiency in comparison with the context-free and the statistical parametric mapping (SPM) approaches. We propose another approach for detecting brain activity by introducing non-Gaussian and non-stationary Gaussian image models that exploit local subband image statistics in the non-decimated wavelet domain. These statistical models, being very simple and tractable, have demonstrated state-of-the-art performance in a number of applications including lossy image compression, denoising and digital watermarking. Such an approach yields close form analytical solutions with low computational complexity that makes it very attractive in neuropsychological research allowing to obtain theoretical performance limits. These models in the scope of the Bayesian estimation framework are applied on synthetic fMRI data corrupted by an additive white Gaussian noise (AWGN) with varying variance and on real fMRI data obtained from a motor preparation task. Comparison of the results with those obtained using SPM maps demonstrates the high efficiency of the proposed method.
7.5.1 α-Cyclodextrin Functionalized Planar Bragg Grating Sensor for the Detection of Small Arene Traces in Solvent Vapour (2012)

We report on an optical sensor system, which is highly sensitive to small traces of arenes in solvent vapour. The sensor system is based on a planar Bragg grating refractive index sensor which is sensitised towards arenes by applying a thin layer of substituted α-cyclodextrins to the sensor surface by dip coating. In our studies using benzene as a representative of arenes, the dependence of the spectral shift of the reflected Bragg wavelength on variation of the benzene concentration was found to 8 pm/100 ppm. Considering the spectral resolution of the interrogation system with reliable signal identification, this leads to a minimum detectable benzene concentration of 75 ppm.
Adhesion of the subacromial bursa may cause subacromial impingement in patients with rotator cuff tearsPressure measurements in 18 patients (2004)

In order to determine whether adhesion of the subacromial bursa leads to impingement, we measured the subacromial contact pressures before and after release of adhesion of this bursa. 18 shoulders with cuff tears and adhesion of the subacromial bursa were evaluated in 8 male and 10 female patients, of mean age 62 (53-71) years and who had no particular limitation of shoulder motion. We recorded subacromial pressures using a very sensitive film inserted under the acromion during surgery. In passive scapular plane elevation (scaption) at 100 degrees, the mean subacromial contact pressure and area declined from 1.43 (SD 0.23) MPa before release to 1.14 (SD 0.35) MPa after release (p < 0.001), and from 163 (SD 81) mm2 before release to 80 (SD 46) mm2 after release (p < 0.001), respectively. We suggest that adhesion of the subacromial bursa increases impingement between the acromion and the insertion of rotator cuff tendons.
Studies on the Biosynthesis of the Terpenoid Side Chains of Quinones (2008)

This chapter contains section titled: References Discussion
Distillation of Natural Fatty Acids and Their Chemical Derivatives (2012)

Well over 1,000 different fatty acids are known which are natural components of fats, oils (triacylglycerols), and other related compounds (Gunstone & Norris, 1983). These fatty acids can have different alkyl chain lengths (typically ten or more carbon atoms), 0-6 carbon-carbon double bonds posessing
Retrievals of Aerosol and Cloud Particle Microphysics Using Polarization and Depolarization Techniques (2001)

The recent availability of theoretical techniques for computing single and multiple scattering of light by realistic polydispersions of spherical and nonspherical particles and the strong dependence of the Stokes scattering matrix on particle size, shape, and refractive index make polarization and depolarization measurements a powerful particle characterization tool. In this presentation I will describe recent applications of photopolarimetric and lidar depolarization measurements to remote sensing characterization of tropospheric aerosols, polar stratospheric clouds (PSCs), and contrails. The talk will include (1) a short theoretical overview of the effects of particle microphysics on particle single-scattering characteristics; (2) the use of multi-angle multi-spectral photopolarimetry to retrieve the optical thickness, size distribution, refractive index, and number concentration of tropospheric aerosols over the ocean surface; and (3) the application of the T-matrix method to constraining the PSC and contrail particle microphysics using multi-spectral measurements of lidar backscatter and depolarization.
The P2Y2 receptor regulates lipoprotein receptor‐related protein 1 expression in smooth muscle cells (2012)

Extracellular nucleotides exert various effects in the cardiovascular system. Uridine 5′‐triphosphate (UTP) regulates G‐protein‐coupled P2Y 2 receptor (P2Y 2 R) activation which causes actin cytoskeletal reorganization. We isolated aortic smooth muscle cells (SMC) from wild‐type (WT) and P2Y 2 R−/− mice to investigate whether UTP and the P2Y 2 R modulate expression of low density lipoprotein receptor‐related protein 1 (LRP1) and low density lipoprotein receptor (LDLR). For LRP1 expression, cells were stimulated in the presence or absence of 100 μM UTP overnight. For LDLR mRNA expression, cells were transiently transfected for 24 h with cDNA encoding a hemagglutinin‐tagged WT P2Y 2 R or a mutant P2Y 2 R that does not bind filamin‐A (FLN‐A) and treated with 100 μM UTP overnight. Total RNA was isolated, reversed transcribed to cDNA, and mRNA abundance determined by RT‐PCR using the ΔCt method with GAPDH as a control gene. Results show SMC expressing the P2Y 2 R that lacks the FLN‐A binding domain exhibit 3‐fold lower LDLR expression than SMC expressing the WT P2Y 2 R. However, there was a 3‐fold increase in LRP1 mRNA expression in response to UTP in P2Y 2 R−/− SMC compared to WT. Actinomycin‐D (20 μg/ml) significantly reduced UTP‐induced LRP1 mRNA expression in P2Y 2 R−/− SMC ( P < 0.05). These results might indicate the presence of a P2Y 4 R in P2Y 2 R−/− SMC as a possible cause for the effect of UTP, which is being further investigated.