gebhart/patrepeval huggingface dataset:
Mantle Cell Lymphoma With MYC Rearrangement (2016)

MYC rearrangement in mantle cell lymphoma (MCL) is rare, and its clinicopathologic significance is not well defined. We report 17 cases of MCL with 8q24/MYC rearrangement, detected at the time of initial diagnosis of MCL in 10 patients and subsequently during the clinical course in 7 patients. There were 12 men and 5 women with a median age of 61 years (range, 49 to 81 y). Fourteen patients had lymphadenopathy (Ann Arbor stage III/IV), and 3 patients presented with a leukemic pattern without lymphadenopathy. Thirteen of 14 patients with available karyotyping data had a complex karyotype. In 8 cases the partner chromosome locus was an IG locus: t(8;14) (n=7) and t(8;22) (n=1). When MYC rearrangement was detected, most patients had a high-risk MCL international prognostic index, and the lymphoma cells had histologically aggressive features. Immunophenotypic analysis showed that the lymphoma cells were positive for cyclin D1 (n=16/16), Myc (9/11), and P53 (n=9/9). The Ki-67 proliferation rate was high (≥60%) in 10/11 cases. All patients received chemotherapy. The median follow-up time was 23 months. Clinical follow-up was available for 14 patients and treatment response in 13 patients. Eleven of 13 patients had refractory or relapsed disease, and 11 patients died. In conclusion, MCL with MYC rearrangement is characterized by advanced-stage disease, aggressive morphologic features, a high proliferation rate, p53 expression, a complex karyotype, and a poor prognosis. We believe these neoplasms fit within the overall concept of double-hit lymphoma, and the designation double-hit MCL may be helpful. We also believe that MYC rearrangement in MCL conveys important prognostic information that should be incorporated into the pathology report.
Replacing styrene with bioderived alternatives in polyesters (2015)

Composites offer high strength and stiffness at a lower density compared to other structural materials, therefore are of growing use to a variety of lightweight structures in order to reduce emissions and improve performance. However, traditional composites have the highest embodied carbon content of all engineering materials with limited methods of recycling. Therefore moving composites to a biobased sourcing can have a large impact in the eco-footprint of these materials. 2-Methoxy-4-vinylphenol has previously been shown to be sustainably biosourced from microbial degradation of lignin and has been termed ‘biostyrene’. In this work, the authors investigate the use of 2-methoxy-4-vinylphenol analogues as a replacement for styrene as a reactive thinner for thermoset polyester, which is commonly used in fibreglass composite. 2-Methoxy-4-vinylphenyl acetate and 2-methoxy-4-vinylphenyl oleate were synthesised and along with unmodified 2-methoxy-4-vinylphenol and 1,2-dimethoxy-4-vinylbenzene (3,4-dimethoxystyrene) were compared to styrene in typical polyester formulations. The mechanical properties by way of tensile tests and water-uptake tests and thermal properties by way of dynamic scanning calorimetry were used for comparison. Overall, the solubility issues were apparent using the biostyrenes, however, blends of biostyrenes with styrene of up to 50% showed no statistical difference with pure styrene in properties and so may be a viable styrene replacement in polyester used for fibreglass.
On-chip antenna design for UHF RFID (2008)

An on-chip antenna suitable for radio frequency identification at UHF band is presented. It is integrated with an EPC Class 1 Generation 2 compatible tag in SMIC 0.18 µm standard CMOS process. The tag achieves a 1 cm communication distance with 1 W reader output power.
Patient Quality of Life Improvements with and without Computer Assistance in Sinus Surgery: Outcomes Study (2006)

Quality of life restrictions in patients with chronic rhinosinusitis were greatest in the areas of nasal symptoms and sleep deprivation, which were significantly improved by endoscopic sinus surgery. Although the long-term effect of CASS as measured by patient quality of life remains relatively unknown, there appears to be a significant trend indicating greater quality of life improvement in the short- term over non-computer-assisted FESS techniques.
Arsenic Flux Dependence of Island Nucleation on InAs(001) (2002)

The initial stages of InAs(001) homoepitaxial growth are investigated using a combination of kinetic Monte Carlo simulations based on ab initio density functional theory and scanning tunneling microscopy. In the two dimensional island nucleation mode investigated, the island number density is found to decrease with increasing As. This behavior is explained by a suppression of the effective In-adatom density leading to a reduction in island nucleation. The relevant microscopic processes responsible for this reduction are identified.
Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2 (2016)

Breast and ovarian cancer (BC/OC) predisposition has been attributed to a number of high- and moderate to low-penetrance susceptibility genes. With the advent of next generation sequencing (NGS) simultaneous testing of these genes has become feasible. In this monocentric study, we report results of panel-based screening of 14 BC/OC susceptibility genes (BRCA1, BRCA2, RAD51C, RAD51D, CHEK2, PALB2, ATM, NBN, CDH1, TP53, MLH1, MSH2, MSH6 and PMS2) in a group of 581 consecutive individuals from a German population with BC and/or OC fulfilling diagnostic criteria for BRCA1 and BRCA2 testing including 179 with a triple-negative tumor. Altogether we identified 106 deleterious mutations in 105 (18%) patients in 10 different genes, including seven different exon deletions. Of these 106 mutations, 16 (15%) were novel and only six were found in BRCA1/2. To further characterize mutations located in or nearby splicing consensus sites we performed RT-PCR analysis which allowed confirmation of pathogenicity in 7 of 9 mutations analyzed. In PALB2, we identified a deleterious variant in six cases. All but one were associated with early onset BC and a positive family history indicating that penetrance for PALB2 mutations is comparable to BRCA2. Overall, extended testing beyond BRCA1/2 identified a deleterious mutation in further 6% of patients. As a downside, 89 variants of uncertain significance were identified highlighting the need for comprehensive variant databases. In conclusion, panel testing yields more accurate information on genetic cancer risk than assessing BRCA1/2 alone and wide-spread testing will help improve penetrance assessment of variants in these risk genes.
Pedicled vastus lateralis musculofascial flap as a new technique for repairing rectourethral fistula after radical prostatectomy (2011)

We present a case of successful operative management of an iatrogenic rectourethral fistula with a pedicled vastus lateralis musculofascial flap. The fistula was created during radical prostatectomy operation. During the operation, it was deemed possible to spare this patient from a diverting colostomy and primarily repair a rectal injury. Postoperatively, however, a rectourethral fistula occurred, which was confirmed on retrograde urethrogram. A first attempt failed to close the fistula utilizing the transanal rectal flap advancement technique. A novel technique was attempted using a pedicled vastus lateralis musculofascial flap. This is the first report to our knowledge of repairing a rectourethral fistula with a pedicled vastus lateralis musculofascial flap.
Simple, Efficient and Convenient Synthesis of<i>O,S</i>-Diethyl Bromomethyl(methyl)thiomalonate (1993)

O,S-Diethyl bromomethyl(methyl)thiomalonate (3) has been prepared in a short, efficient synthesis from commercially available ethyl 2-cyanopropionate (1).
TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population (2007)

The TCF7L2 rs7903146 variant neither increases the risk for SGA nor modulates birth weight and young adulthood glucose homeostasis in French Caucasian subjects born with SGA.
Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720 (2003)

Graft-versus-host disease (GvHD) mediated by donor T cells recognizing host alloantigens is associated with beneficial graft-versus-tumor effects in recipients of allogeneic hematopoietic cell transplants. Since leukemias and lymphomas reside largely within the lymphohematopoietic system, we have proposed that the desired graft-versus-leukemia or graft-versus-lymphoma effect can be separated from the complication of GvHD by confinement of the graft-versus-host alloresponse to the lymphohematopoietic tissues. Since the new sphingosine-1-phosphate receptor agonist immunosuppressive drug FTY720 leads to trapping of T cells in secondary lymphoid tissues, we evaluated the possibility that this drug could diminish GvHD, a disease involving epithelial target tissues, while permitting a beneficial alloresponse to take place within the lymphohematopoietic system, leading to graft-versus-lymphoma effects. We demonstrate here that FTY720 markedly reduces GvHD in a clinically relevant, haploidentical strain combination, while permitting antitumor effects against a T cell lymphoma of unshared host MHC haplotype to proceed unhindered. These results establish a potential new immunotherapeutic approach to separating graft-versus-leukemia effects from GvHD.
Quantifying Effusion Rates at Active Volcanoes through Integrated Time-Lapse Laser Scanning and Photography (2015)

During volcanic eruptions, measurements of the rate at which magma is erupted underpin hazard assessments. For eruptions dominated by the effusion of lava, estimates are often made using satellite data; here, in a case study at Mount Etna (Sicily), we make the first measurements based on terrestrial laser scanning (TLS), and we also include explosive products. During the study period (17–21 July 2012), regular Strombolian explosions were occurring within the Bocca Nuova crater, producing a ~50 m-high scoria cone and a small lava flow field. TLS surveys over multi-day intervals determined a mean cone growth rate (effusive and explosive products) of ~0.24 m3·s−1. Differences between 0.3-m resolution DEMs acquired at 10-minute intervals captured the evolution of a breakout lava flow lobe advancing at 0.01–0.03 m3·s−1. Partial occlusion within the crater prevented similar measurement of the main flow, but integrating TLS data with time-lapse imagery enabled lava viscosity (7.4 × 105 Pa·s) to be derived from surface velocities and, hence, a flux of 0.11 m3·s−1 to be calculated. Total dense rock equivalent magma discharge estimates are ~0.1–0.2 m3·s−1 over the measurement period and suggest that simultaneous estimates from satellite data are somewhat overestimated. Our results support the use of integrated TLS and time-lapse photography for ground-truthing space-based measurements and highlight the value of interactive image analysis when automated approaches, such as particle image velocimetry (PIV), fail.
Micromachining for improvement of integrated ultrasonic transducer sensitivity (1990)

A micromachined diaphragm structure for integrated ultrasonic transducers is discussed. The micromachining significantly reduces a large parasitic capacitance, resulting in improved sensitivity compared with identical transducers on solid substrates. For the particular geometry tested, sensitivity improved 8.9 dB; this result matches a prediction of 10.9 dB, based on a simple model, reasonably well. This level of improvement is considered significant for the applications under consideration (medical imaging and nondestructive evaluation).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ChemInform Abstract: Catalytic Oxidation of Alcohols to Carbonyl Compounds over Hydrotalcite and Hydrotalcite‐Supported Catalysts (2015)

Abstract Review: 76 refs.
Recent Tendency of Oilseed Protein Utilization (1989)

The production of oilseed meals is increasing in the world. However their utilization for food is very few and only 10% soy bean meal is used for food processing in Japan. Soy protein products are classified into powder, texture and fiber type and a lot of fuctional properties are revealed according to their types. So, the products are being used as improver of processed food such as meat and fish paste products, delicatessen, etc. In addition, recently 100of chemical score and cholesterol lowering effect for soy protein has been reported and indicated that it is an excellent nutritional protein source for human. Due to the above, new style food products which soy protein products are subjective have been developing for consumer market. In spite of many researchers' efforts, other oilseed proteins have not yet been resolved their individual problems, antinutrients, toxins, color, flavor, etc. and utilization for food materials is limited.
The Role of the Shin Nihon Hakkei in Redrawing Japanese Attitudes to Landscape (2016)

This chapter provides a critical analysis of the Shin Nihon Hakkei (hereafter Hakkei), a canon of eight ‘new’ landscape sites that were nominated in 1927 following an opinion poll jointly conducted by two newspaper companies, the Tokyo Nichinichi Shinbunsha and Osaka Mainichi Shinbunsha. At first glance, the Hakkei’s ostensible aim of showcasing the nation’s finest landscapes in eight pre-determined geophysical categories seems relatively innocuous. Yet the poll marked an important shift toward the nation-building imperatives of the new era, particularly as it was timed to commemorate the transition from Taishō (1912–25) to Shōwa (1926–89) periods by simultaneously promoting characteristically ‘Japanese’ landscape along with ‘modern’ Western aesthetics and concepts of scenic beauty.
ENDOSCOPIC RESPONSE TO CHEMORADIOTHERAPY IN LOW RECTAL CANCER: ARE THE WAIT-AND-SEE CRITERIA TOO STRICT? (2018)

In the wait-and-see (W&S) strategy, locally advanced low rectal adenocarcinoma patients who achieve clinical complete response (cCR) after chemoradiotherapy (CRT) undergo regular surveillance, with surgery being reserved for tumor “regrowth”. Endoscopic complete response is characterized by light/white mucosa, scar, telangiectasia or edema. Erosion and ulceration are considered an absence of response.
Establishing Plane Hypotheses from 3D Contours for Scene Recognition of Visual Intelligence (1991)

A robust method to derive hypotheses for planar surfaces of3D objects from noisy contours,is reported.
α→γ→α Transformation Texture Formation at Cold-Rolled Ultra Low Carbon Steel Surfaces (2005)

The influence of Mn on the surface texture formation through a®g®a transformation was investigated. After the a®g®a transformation, a weak texture was formed at the surface of ultra low carbon cold-rolled sheet steel without Mn. In contrast, a sharp <100>//ND cube texture was observed in Mn alloyed ultra low carbon steel. In order to interpret the effect of Mn two alternative mechanisms were considered : (i) one assumption attributes the occurrence of the specific surface texture to the effect of outer-surface energy (ii) and according to an alternative hypothesis the release of elastic work parallel to ND in the surface area is responsible for the observed <100>//ND surface texture.
Characterization of Tunable Metamaterial Elements (2007)

An experimental demonstration and analysis of a dual-state switchable magnetic metamaterial element in which the resonance excitation of the particle is controlled using an RF mi- croelectromechanical (MEMS) switch is presented. By controlling the resonant properties of the individual ring, unit cells composed of such elements can be used to realize an effective dual-state switchable medium. Transmission and loss characteristics of the switchable element for two different switch topologies are com- pared. Experimental data shows that the MEMS switch allows for a switchable resonant particle with reasonably low losses. Index Terms—Metamaterials, microelectromechanical (MEMS).
Defective Lamellar Phases and Micellar Polymorphism in Mixtures of Glycerol Monooleate and Cetyltrimethylammonium Bromide in Aqueous Solution (1998)

The phase behavior of solvent-rich mixtures of glycerol monooleate and cetyltrimethylammonium bromide is reported for two solvents, water and aqueous solutions of 100 mM NaCl. The main concern is the properties of the lamellar phases and the formation of curvature defects within the bilayers. Defective lamellar phases are shown to form in both water and brine. The defective regions of lamellar phase are delineated by means of small-angle X-ray scattering (SAXS) studies. Direct visualization of the aggregate structure at high dilution is made by cryo-transmission electron microscopy (cryo-TEM). A rich micellar polymorphism is found, involving connected threadlike micelles as well as elongated micelles with noncircular cross sections. The correlation between the observed aggregate structures and the overall phase behavior is used to discuss possible defect geometries in the disrupted bilayers. We also report that the water-based lamellar phase made from the intact bilayers seems to contain a large fraction of curved multilamellar aggregates. Interestingly, the corresponding bilayers that show curvature defects appear to build lamellar phases free of such textural defects.
Appraising world energy prospects (1980)

Abstract The authors begin by outlining a multi‐scenario technique for coping with future uncertainty in assessments of the business environment for energy planning. The discussion then leads to a quantification of world energy demand under two exploratory scenarios, whose results are compared with published forecasts. Analysis of the components of demand highlights the importance of the Third World. After a review of the world's fossil fuel resources, the likely effective availability of oil and other energy sources (including nuclear power and the renewables) is set against the scenario levels of energy demand. The paper ends with a summary of the implications for action in the field of energy.
Specific reduction of wheat storage proteins by thioredoxin h (1992)

International audience
Effect of high-intensity ultrasound on superconducting properties of polycrystalline YBa2Cu3O7−x (2013)

Abstract. High intensity ultrasonic irradiation (sonication) of alkane slurries of polycrystalline YBa2Cu3O7−x leads to a significant modification of the grain morphology and, if performed with enforced oxygen flow, results in the increase of the superconducting transition temperature. Sonication with added Fe(CO)5 produces magnetic Fe2O3 nanoparticles deposited on the surface of YBa2Cu3O7−x (YBCO) granules. Upon sintering these nanoparticles should act as efficient pinning centers utilizing both condensation and magnetic contributions to the free energy. The developed method could become a major technique to produce practically useful high-pinning nanocomposite materials based on YBa2Cu3O7−x superconductor.
Inhibitory Effect of Sarcophytol A on Development of Spontaneous Hepatomas in Mice (1991)

The inhibitory effect of sarcophytol A, a cembrane-type diterpene isolated from a marine soft coral, Sarcophyton glaucum, on development of spontaneous hepatomas was investigated in C3H/HeNCrj mice. A total of 80 mice were divided equally into two groups. The experimental and control groups were given basal diets with and without 0.01% sarcophytol A, respectively. At week 65 of the experiment, mice were examined for hepatomas. The percentages of hepatoma-bearing mice of the subgroup with three or more tumors and the tumor diameters of the group treated with sarcophytol A were smaller than those of the control group. Ridit analysis revealed that these differences were statistically significant. The body weight gain, and the food intake were not significantly different between these two groups. Analysis of blood serum revealed that feeding the diet containing 0.01% sarcophytol A for 65 weeks did not show any adverse effects. These results suggest that sarcophytol A inhibits the development of spontaneous hepatomas without toxicity, and should be considered as a possible cancer chemopreventive agent for hepatomas in humans.
THREE-DIMENSIONAL STRUCTURE OF THYMIDINE PHOSPHORYLASE FROM ESCHERICHIA COLI AT 2.8 ANGSTROMS RESOLUTION (1990)

The three-dimensional structure of thymidine phosphorylase from Escherichia coli has been determined at 2.8 A resolution using multiple-isomorphous-replacement techniques. The amino acid sequence deduced from the deoA DNA sequence is also reported. Thymidine phosphorylase exists in the crystal as an S-shaped dimer in which the subunits are related by a crystallographic 2-fold axis. Each subunit is composed of a small alpha-helical domain of six helices and a large alpha/beta domain. The alpha/beta domain includes a six-stranded mixed beta-sheet and a four-stranded antiparallel beta-sheet. The active site has been identified by difference Fourier analyses of the binding of thymine and thymidine and lies in a cavity between the small and large domains. The central beta-sheet is splayed open to accommodate a putative phosphate-binding site which is probably occupied by a sulfate ion in the crystal.
Synthesis, DNA Cleavage Activity, Cytotoxicity, Acetylcholinesterase Inhibition, and Acute Murine Toxicity of Redox‐Active Ruthenium(II) Polypyridyl Complexes (2017)

Four mononuclear [(L-L)<sub>2</sub> Ru(tatpp)]<sup>2+</sup> and two dinuclear [(L-L)<sub>2</sub> Ru(tatpp)Ru(L-L)<sub>2</sub> ]<sup>4+</sup> ruthenium(II) polypyridyl complexes (RPCs) containing the 9,11,20,22-tetraazatetrapyrido[3,2-a:2',3'-c:3'',2''-l:2''',3'''-n]pentacene (tatpp) ligand were synthesized, in which L-L is a chelating diamine ligand such as 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen), 3,4,7,8-tetramethyl-1,10-phenanthroline (Me<sub>4</sub> phen) or 4,7-diphenyl-1,10-phenanthroline (Ph<sub>2</sub> phen). These Ru-tatpp analogues all undergo reduction reactions with modest reducing agents, such as glutathione (GSH), at pH 7. These, plus several structurally related but non-redox-active RPCs, were screened for DNA cleavage activity, cytotoxicity, acetylcholinesterase (AChE) inhibition, and acute mouse toxicity, and their activities were examined with respect to redox activity and lipophilicity. All of the redox-active RPCs show single-strand DNA cleavage in the presence of GSH, whereas none of the non-redox-active RPCs do. Low-micromolar cytotoxicity (IC<sub>50</sub> ) against malignant H358, CCL228, and MCF7 cultured cell lines was mainly restricted to the redox-active RPCs; however, they were substantially less toxic toward nonmalignant MCF10 cells. The IC<sub>50</sub> values for AChE inhibition in cell-free assays and the acute toxicity of RPCs in mice revealed that whereas most RPCs show potent inhibitory action against AChE (IC<sub>50</sub> values <15 μm), Ru-tatpp complexes as a class are surprisingly well tolerated in animals relative to other RPCs.
Natural abundance <sup>17</sup>O NMR spectroscopy of heteroaromatic Nitro compounds (1986)

Abstract The 17 O chemical shift data, at natural abundance, for selected nitroquinolines, nitroindoles, nitroindazoles and nitrothiophenes are reported. In the absence of a peri or a lone‐pair repulsion effect, the nitroquinolines' chemical shifts differ little from those of their carbocyclic analogs. However, the signal for 5‐nitroquinoline, 2 , is deshielded by 25 ppm compared to 6‐nitroquinoline, 1 , and the 17 O nucleus in 8‐nitroquinoline, 3 , is deshielded by 49 ppm compared to that in 1 . Both these shifts are attributed to rotation of the nitro group from the plane of the heteroaromatic ring arising from peri hydrogen interaction and lone pair repulsion, respectively. The signals for nitro groups on electron excessive ring systems ( e.g. , indoles and thiophenes) are shielded relative to corresponding ones in electron deficient heterocyclic ring system analogs. The chemical shifts for the π‐excessive systems are interpreted in terms of electronic effects.