gebhart/patrepeval huggingface dataset:
Frequency of JCAHO-mandated medication inspections (1991)

Journal Article Frequency of JCAHO-mandated medication inspections Get access Charles E. Myers, M.S., M.B.A., Charles E. Myers, M.S., M.B.A. Associate Director Professional Practice Division Search for other works by this author on: Oxford Academic Google Scholar Henry A. Woodson, Jr. Henry A. Woodson, Jr. Associate Director Department of Standards Joint Commission on Accreditation of Healthcare Organizations One Renaissance Boulevard Oakbrook Terrace, IL 60181 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 48, Issue 5, 1 May 1991, Page 914, https://doi.org/10.1093/ajhp/48.5.914 Published: 01 May 1991
The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements (1996)

The different forms of the Oct-2 and Brn-3 POU family transcription factors can have distinct effects on their target promoters involving both the activation and repression of gene expression. To investigate the requirements for these effects we have altered both the context and spacing of the two TAATGARAT binding sites for these factors within the herpes simplex virus immediate-early 3 gene promoter. We show that the activation of this promoter by Brn-3a and its repression by Brn-3b is dependent on the correct spacing of these binding sites. In contrast, repression of the promoter by Oct-2.4 and Oct-2.5 is dependent on both the spacing and context of these sites with the requirements for repression by Oct-2.4 or Oct-2.5 being different. These effects are discussed in the context of the mechanisms by which POU factors activate or repress their target genes.
<title>Novel method for persistent holographic recording in doubly doped lithium niobate</title> (1999)

We present a novel method for recording persistent holograms in doubly-doped LiNbO<SUB>3</SUB>. Simultaneous sensitization of the crystal by an inhomogeneous UV beam can result to 32% diffraction efficiency recorded by red light in a 0.85 mm thick sample, while read-out with only red light is non- destructive. Rapid optical erasure by ultraviolet light is possible and light scattering is efficiently prevented.
Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay (2013)

Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical effector of cellular phenotype, i.e., proteins, tight regulation of both the quality and quantity of mRNA is a prerequisite for effective cellular homeostasis. Here, we review nonsense-mediated mRNA decay (NMD), which is the best-characterized posttranscriptional quality control mechanism that cells have evolved in their cytoplasm to ensure transcriptome fidelity. We use protein quality control as a conceptual framework to organize what is known about NMD, highlighting overarching similarities between these two polymer quality control pathways, where the protein quality control and NMD pathways intersect, and how protein quality control can suggest new avenues for research into mRNA quality control.
Young Leaders for Biology in India (2010)

Many developing countries in Asia are rapidly building new Research Institutes, eager to establish a vibrant and progressive scientific enterprise on a nationwide scale. As Huang and Tan point out in the Policy Forum on p. 1471, this buildup of scientific infrastructure must be combined with changes in culture that promote innovation and collaboration, which are required ingredients for recruiting a new generation of outstanding scientists. India, a nation faced with such challenges, is engaged in a promising grassroots experiment aimed at attracting back talented young researchers and fostering a new scientific culture in the biological sciences.
Prenatal diagnosis and management of junctional ectopic tachycardia (2017)

Junctional ectopic tachycardia (JET) is one of the rarest forms of fetal tachycardia. When associated with maternal anti-SSA (Sjogren) antibodies,1,2 JET is intermittent, with variable fetal heart rate (FHR) and decreases in frequency as gestation progresses. In the absence of anti-SSA antibodies, JET can also present as an incessant tachycardia with minimal heart rate variability, 1:1 ventriculoatrial (VA) conduction, or VA dissociation and discordant atrial and ventricular rates.3–6 Incessant JET with 1:1 VA conduction can mimic sinus tachycardia, a slow atrioventricular reentrant tachycardia (AVRT), accelerated ventricular rhythm, or slow ventricular tachycardia by fetal echocardiography/Doppler.
[Multicystic neonatal encephalopathy after a traffic accident with minor maternal injuries]. (1999)

We report a case of traffic accident at 30 weeks of gestation. The maternal injuries were minor. The fetal heart rate patterns showed tachycardia and decreased modulation. Ultrasound scanning was normal, without abruptio placentae. Ten days after the accident, a cesarean section was done on altered fetal heart rate with a normal infant at birth. This baby died 17 days latter from an ischemic multicystic encephalomalacia. With the view of the literature, we try to explain the pathophysiological mechanism of this severe fetal outcome despite minor maternal injuries. Hypovolemic collapsus, caval syndrome and maternal stress could be the cause of placental hypoperfusion. Abruptio placenta and feto-placental hemorrhage are others explanations. We propose the management for first aid workers and the specialized unit care.
ChemInform Abstract: SYNTHESE EINES BIS‐ADENOSIN‐DERIVATES ALS ANALOGEN ZUM UEBERGANGSZUSTAND DER TRNA‐ABHAENGIGEN PEPTIDKONDENSATION (1975)

Abstract Die Vorstufe (Ia)/(Ib) (keine Strukturzuordnung) zur Synthese der Titelverbindungen (IV) wird durch Kondensation von Adenosin mit Lävulinsäureäthylester in Gegenwart von Orthoameisensäuretriäthylester unter säurekatalysierten Bedingungen nach 20stündiger Reaktionszeit in 7l%iger Ausbeute erhalten.
Nucleic acid related compounds. 35. Synthesis of 5-bromo- and 5-deuterio-3-deazauridine (1981)

Bromination of 3-deazauracil (4-hydroxy-2-pyridinone) (1) gave the 3,5-dibromo compound (2). Selective debromination of 2 gave 5-bromo-4-hydroxy-2-pyridinone (3). Trimethylsilylation of 3 and condensation of the product (4) in situ with tetra-O-acetyl-β-D-ribofuranose (5) using tin(IV) chloride as catalyst gave 1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-5-bromo-4-hydroxy-2-pyridinone (7). Deprotection of 7 gave 5-bromo-3-deazauridine (6). Catalytic hydrogenolysis of 7 gave 3-deazauridine triacetate (8a) and deuteriolysis gave the 5-deuterio product (8b). Deprotection of 8b gave the isotope-labeled anticancer agent, 5-deuterio-3-deazauridine (9). Biochemical and clinical implications are discussed.
A conserved ring of charge in mammalian Na<sup>+</sup> channels: a molecular regulator of the outer pore conformation during slow inactivation (2006)

The molecular mechanisms underlying slow inactivation in sodium channels are elusive. Our results suggest that EEDD, a highly conserved ring of charge in the external vestibule of mammalian voltage-gated sodium channels, undermines slow inactivation. By employing site-directed mutagenesis, we found that charge alterations in this asymmetric yet strong local electrostatic field of the EEDD ring significantly altered the kinetics of slow inactivation gating. Using a non-linear Poisson-Boltzmann equation, quantitative computations of the electrostatic field in a sodium channel structural model suggested a significant electrostatic repulsion between residues E403 and E758 at close proximity. Interestingly, when this electrostatic interaction was eliminated by the double mutation E403C + E758C, the kinetics of recovery from slow inactivation of the double-mutant channel was retarded by 2500% compared to control. These data suggest that the EEDD ring, located within the asymmetric electric field, is a molecular motif that critically modulates slow inactivation in sodium channels.
A Density Functional Study of the Systems [MH<sub>3</sub>(PMe<sub>3</sub>)<sub>4</sub>]<sup>+</sup> (M = FE, RU, OS) (1997)

Abstract The structures and relative energies of various isomers of [FeH 3 (PMe 3 ) 4 ) + ( 1 ), [RuH 3 (PMe 3 ) 4 ]. ( 2 ) and [OsH 3 (PMe 3 ) 4 ]. ( 3 ) have been studies by density functional theory. The stereoisomers considered are derived from a tetrahedral (T), square planar (P), and C 2v ‐butterfly (C) arrangement of the phosphane ligands. For the latter two, classical trihydride ( I ) and nonclassical hydride/dihydrogen ( II ) geometries have been considered 1 and 2 prefer coordination mode II , whereas 3 favours coordination mode I . This trend is explained by relativistic effects. For Fe and Os, the C and T type structures are preferred over a P geometry. for Ru, the C and P structures are close in energy, and the T arrangement represents the highest energy isomer.
Precise measurement of diffusion by multi-color dual-focus fluorescence correlation spectroscopy (2008)

Dual-focus fluorescence correlation spectroscopy is a method for precisely measuring the diffusion coefficient of fluorescing molecules close to the infinite dilution limit in a reference-free and absolute manner. We apply the method to determine the diffusion coefficients of three fluorescent dyes across the visible spectrum. These values can be used as absolute reference standards for fluorescence correlation spectroscopy. In particular, it is found that the diffusion coefficient of the widely used reference dye Rhodamine 6G is by 37% larger than the value used in most publications on fluorescence correlation spectroscopy over the last three decades.
Design space exploration of FPGA-based Deep Convolutional Neural Networks (2016)

Deep Convolutional Neural Networks (DCNN) have proven to be very effective in many pattern recognition applications, such as image classification and speech recognition. Due to their computational complexity, DCNNs demand implementations that utilize custom hardware accelerators to meet performance and energy-efficiency constraints. In this paper we propose an FPGA-based accelerator architecture which leverages all sources of parallelism in DCNNs. We develop analytical feasibility and performance estimation models that take into account various design and platform parameters. We also present a design space exploration algorithm for obtaining the implementation with the highest performance on a given platform. Simulation results with a real-life DCNN demonstrate that our accelerator outperforms other competing approaches, which disregard some sources of parallelism in the application. Most notably, our accelerator runs 1.9× faster than the state-of-the-art DCNN accelerator on the same FPGA device.
Influence of Microparticles on the Homogeneity of Distribution of Topically Applied Substances (2008)

The uppermost layer of the skin--the stratum corneum--represents a barrier of the human organism to the environment. It prevents the penetration of substances coming into contact with the skin into the human body. In cases of strong exposure, the skin has to be protected additionally by barrier creams. In the present study, the influence of microparticles on the homogeneity of distribution of the protection cream on the skin was investigated by laser scanning microscopy. The protection cream contained antioxidant substances with a high radical protection factor for the prevention of palmar-plantar erythema often occurring during chemotherapy with doxorubicin. In this case, the chemotherapeutic substance comes out with the sweat onto the skin surface, from which it penetrates into the skin like topically applied. It was found that particles increase the homogeneity of distribution and, thus, the protection efficacy is significantly increased. The obtained results are important, not only for the prevention of side effects during chemotherapy, but also for the development and application of sunscreens and all types of topically applied drugs and cosmetics, which should form an efficient protection film on the skin.
153: Successful Gold Nanoshell Assisted Laser Ablation of Prostate Carcinoma in Vitro (2007)

You have accessJournal of UrologyModerated Poster 6, Sunday, May 20, 2007, 8:00 - 10:00 am1 Apr 2007153: Successful Gold Nanoshell Assisted Laser Ablation of Prostate Carcinoma in Vitro Joshua M. Stem, Jer-Tsang Hsieh, Sangtae Park, Yair Lotan, and Jeffrey A. Cadeddu Joshua M. StemJoshua M. Stem More articles by this author , Jer-Tsang HsiehJer-Tsang Hsieh More articles by this author , Sangtae ParkSangtae Park More articles by this author , Yair LotanYair Lotan More articles by this author , and Jeffrey A. CadedduJeffrey A. Cadeddu More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30418-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "153: Successful Gold Nanoshell Assisted Laser Ablation of Prostate Carcinoma in Vitro." The Journal of Urology, 177(4S), p. 52 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 52 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Joshua M. Stem More articles by this author Jer-Tsang Hsieh More articles by this author Sangtae Park More articles by this author Yair Lotan More articles by this author Jeffrey A. Cadeddu More articles by this author Expand All Advertisement PDF DownloadLoading ...
Running performance of tandem stages traction drive modified from angular contact ball bearings (2006)

Micro-Traction-Drives are made from modified angular-contact ball bearings. It was developed for its small size and transmission of high torque. The structure of a Micro-Traction-Drive is as follows: The traction force is generated by the thrust preload between the inner race and the outer race. The retainer that is connected to the output shaft transmits the driving torque. The retainer is made of copper alloy. Test-runs of the Micro-Traction-Drive have been carried out as the tandem stage type (reduction ratio: 7.3). Results from testing show that a Micro-Traction-Drive has been successfully operated at 20,000 rpm. Furthermore, the output shaft torque, volume of the preload of a Micro-Traction-Drive, and number of balls were examined, resulting in a design manual of the Micro-Traction-Drive.
Abstract 3940: Activation of Signal Transducer and Activator of Transcription 3 (STAT3) in ovarian cancer: The hypoxic implications (2012)

Abstract Background: The hypoxic microenvironment plays a key role in tumorigenesis and the development of therapeutic resistance in epithelial ovarian cancer (EOC). The goal of this study was to examine the expression of STAT3 in hypoxic EOC, to understand its mechanism of activation, and to explore the therapeutic efficacy of a novel compound HO-3867. Methods: Expression of STAT family proteins in cell lines and human tumor specimens was analyzed via western blot and IHC. MTT was used to assess cell viability and apoptotic analysis was performed using flow cytometry. Over-expression or suppression experiments were performed using S1PR1 cDNA and shRNA. Tumor xenografts were made with cell lines exposed to hypoxic preconditioning. Results: pSTAT3 Tyr705 is highly expressed in ovarian cancer cell lines exposed to hypoxia as well as in hypoxic regions of advanced human EOC tumor specimens. Accelerated xenograft tumor growth was observed when implanted cells were pre-conditioned in a hypoxic microenvironment. Similar to our in vitro findings, the tumor xenografts of hypoxic ovarian cancer cells (HOCCs) had high expression of pSTAT3 and its target proteins. We found an increased expression of sphingosine-1-phosphate receptor 1(S1PR1) in HOCCs, a known positive feedback regulator of STAT3 transcription. Suppression of S1PR1 expression with shRNA significantly reduced the expression of pSTAT3 Tyr705 through the inhibition of the JAK kinases, resulting in decreased cell survival. Conversely, overexpression of S1PR1 with cDNA increased pSTAT3 Tyr705 and promoted cell proliferation under hypoxic conditions. Finally, treatment of HOCCs with the novel synthetic compound HO-3867 resulted in decreased expression of pSTAT3 Tyr705, as well as STAT3-regulated proteins VEGF, Bcl-xL, Bcl-2, and cyclin D1. The rapid downregulation of pSTAT3 Tyr705 was associated with accelerated ubiquitin-dependent degradation. An induction of apoptosis contributed to inhibition of cell proliferation as HO-3867-exposed cells exhibited elevated levels of cleaved caspases and PARP. Conclusions: The hypoxic microenvironment results in STAT3 activation as evidenced in our in vitro and in vivo models. S1PR1 is involved in STAT3 Tyr705 activation in hypoxic ovarian cancer via the JAK signaling pathway. The specific targeting of hypoxia-induced tyrosine phosphorylation of STAT3 with HO-3867 is a novel therapeutic strategy in the treatment of hypoxia-mediated chemotherapeutic resistant ovarian cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3940. doi:1538-7445.AM2012-3940
Hardware verification of a hyper-efficient (98%) and super-compact (2.2kW/dm<sup>3</sup>) isolated AC/DC telecom power supply module based on multi-cell converter approach (2015)

Due to the increasing electricity demand of data centers driven by the emergence of cloud computing and big data, the focus on the development of telecom and data center power supplies is shifted towards high efficiencies. In this paper, a multi-cell converter approach for a telecom rectifier module breaking through the efficiency and power density barriers of traditional single-cell converter systems is shown. The comprehensive optimization of the entire system with respect to efficiency and volume is described and the applied component loss models are explained. Furthermore, the design of a hardware demonstrator based on the optimization results is presented and several important design aspects are explained in detail.
A new critical velocity in the dynamic fracture of brittle amorphous materials (2009)

Dynamic fracture experiments were performed in PMMA over a wide range of velocities and reveal that the fracture energy exhibits an abrupt 4-folds increase from its value at crack initiation at a well-defined critical velocity, below the one associated to the onset of micro-branching instability. This transition is associated with the appearance of conics patterns on fracture surfaces that, in many materials, are the signature of damage spreading through the nucleation and growth of micro-cracks. These results suggest a nominally brittle to quasi-brittle transition in the dynamic fracture of amorphous materials the implications of which are discussed.
Alterations in consummatory behavior of mice produced by dietary exposure to inorganic lead (1975)

Mice suckled by mothers given tap water and by mothers given a 5 mg/ml lead acetate solution during lactation were given a choice between tap water and a lead acetate solution after lactation. All offspring demonstrated an immediate aversion to the lead acetate solution. The offspring from the mothers receiving lead acetate during lactation demonstrated a greater aversion to the lead acetate solution than did the offspring from mothers receiving tap water. In addition, the lead acetate offspring drank more total fluid (tap water plus lead acetate solution) after weaning than the control offspring. The results indicate both learned and unlearned changes in motivation for fluid following ingestion of lead via the mother's milk in infancy.
Effects of Baseline CSF α-Synuclein on Regional Brain Atrophy Rates in Healthy Elders, Mild Cognitive Impairment and Alzheimer’s Disease (2013)

With the possible exception of caudate and brainstem, the overall weak effects of CSF α-synuclein on atrophy rates in NL, MCI and AD argues against CSF α-synuclein as a biomarker related to longitudinal brain atrophy in these diagnostic groups. Any effects of CSF α-synuclein may be attenuated by possible simultaneous occurrence of AD-related neuronal injury and concomitant Lewy body pathology, which may elevate and reduce CSF α-synuclein levels, respectively.
Interferon Clearance Rate Decreased after Repeated Injections (1971)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
La tragédie du bien commun (1997)

Programmes informatiques, reproduction transitaire, banque de donnees revelent la difficulte de I'evolution juridique a I'ere cyber.
Analysis of Radiographic Spinopelvic Parameters in Patients With Degenerative Lumbar Kyphoscoliosis (2020)

Abstract Purpose: To analyze the relationships between coronal and sagittal spinopelvic parameters in degenerative lumbar kyphoscoliosis (DLKS). Methods: We enrolled 75 patients with DLKS for a radiographic study between January 2016 and September 2018. Correlations between coronal and sagittal spinopelvic radiographic parameters were analyzed. Then patients were divided into two groups: sagittal balanced group (SVA<= 5cm, 30 patients) and sagittal imbalanced group (SVA> 5cm, 45 patients), and relevant parameters were compared. Results: The Cobb angle and lumbar lordosis of the DLKS patients were 24.87 ± 11.59° and 17.26 ± 12.24°, respectively. The average age was 68 years old (range: 42-82), and the sex ratio was 2.6:1 (female:54 patients; male: 21 patients). 50 patients (66.7%) located convexity of the curve at left side, while 25 patients (33.3%) at right side. The Cobb angle correlated with LL-TK (r = -0.228, p = 0.049), LL (r = -0.255, p = 0.027) and SS (r = -0.232, p = 0.045). There were significant differences in PI-LL (t = -3.484, P = 0.001), LL-TK (t = 2.354, P = 0.023), PI (t = -3201, P = 0.002) and PT (t = -2.521, P = 0.014) between sagittal balanced and imbalanced group. Conclusions: In degenerative lumbar kyphoscoliosis, there are some correlations between coronal and sagittal spinopelvic parameters. Moreover, PI-LL, LL-TK, PI, PT were significantly different between sagittal balanced and imbalanced DLKS patients.