gebhart/patrepeval huggingface dataset:
Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway (2006)

Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53-MDM2 pathway. Here we demonstrate that both p53 and MDM2 specifically recognize the N-terminal tumor necrosis factor-receptor associated factor (TRAF)-like domain of HAUSP in a mutually exclusive manner. HAUSP preferentially forms a stable HAUSP-MDM2 complex even in the presence of excess p53. The HAUSP-binding elements were mapped to a peptide fragment in the carboxy-terminus of p53 and to a short-peptide region preceding the acidic domain of MDM2. The crystal structures of the HAUSP TRAF-like domain in complex with p53 and MDM2 peptides, determined at 2.3-A and 1.7-A resolutions, respectively, reveal that the MDM2 peptide recognizes the same surface groove in HAUSP as that recognized by p53 but mediates more extensive interactions. Structural comparison led to the identification of a consensus peptide-recognition sequence by HAUSP. These results, together with the structure of a combined substrate-binding-and-deubiquitylation domain of HAUSP, provide important insights into regulation of the p53-MDM2 pathway by HAUSP.
Automatic Relational Schema Extraction from Natural Language Requirements Specification Text (2014)

2 Abstract: Recent researches have been focussed greatly on automating the extraction of information from Natural language text and this requires a large amount of domain knowledge. This paper attempts to construct a schema that depicts the interrelationship between tables extracted from natural language requirements specification text. Initially the domain knowledge is extracted from requirements specification text. Following this the schema generator extracts the attributes from the class diagram generated by the domain knowledge extractor. By prioritizing the preferences of the attributes and adjectives present in the text, the key attributes (primary and foreign) are elicited using hand crafted rules. This is done in order to derive the schema for the tables present in the requirement specification text. The extracted schemas are then represented in XML and they are stored in a relational database. Finally the database constructed can be queried to acquire the domain knowledge which eases the job of software development.
Edge-Based Inpainting and Texture Synthesis for Image Compression (2007)

Towards visual quality rather than pixel-wise fidelity, we propose an image coding scheme integrated with edge-based in-painting and texture synthesis. In this scheme, an original image is analyzed at encoder side so that some blocks are removed during encoding. The edges related to these removed blocks will be compressed and transmitted. At decoder side, we propose an image restoration method, which consists of edge-based in-painting and texture synthesis, in order to fully utilize the transmitted edges and naturally restore the removed blocks. Experimental results show that our scheme can achieve up to 32% bit-rate saving at similar visual quality levels, compared with H.264/AVC intra coding.
Chemical firms seek higher motor efficiency (1979)

RETURN TO ISSUEPREVNewsNEXTChemical firms seek higher motor efficiencyIn search for greater energy savings, plant managers and engineers are turning to more efficient electric motors with better power factorsSTEPHEN C. STINSONView Author Information C&EN, New YorkCite this: Chem. Eng. News 1979, 57, 7, 18–19Publication Date (Print):February 12, 1979Publication History Published online7 November 2010Published inissue 12 February 1979https://pubs.acs.org/doi/10.1021/cen-v057n007.p018https://doi.org/10.1021/cen-v057n007.p018newsACS PublicationsCopyright © 1979 AMERICAN CHEMICAL SOCIETYArticle Views6Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Chemical engineering and industrial chemistry,Electrical energy,Food,Manufacturing,Power Get e-Alerts
Mesoporous Metal–Organic Framework with Rare etb Topology for Hydrogen Storage and Dye Assembly (2007)

More holes than Swiss cheese: A new MOF with the largest reported 1D hexagonal nanotube-like channels of 24.5 Å×27.9 Å and rare etb topology has been synthesized (see picture). It exhibits good fluorescence properties and substantial hydrogen uptake. For the first time, the compound was assembled with Rh6G dye molecules, and the product showed favorable temperature-dependent luminescent properties. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700537_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Linear Feature Extraction from SAR Images based on the modified LSD Algorithm (2013)

This paper proposes a new approach for linear feature from SAR images based on the modified LSD algorithm. This approach consists of three steps: computing the information of the edge, extracting the lines and the validating the lines. First, the ROEWA detector and the Gabor filter are used to extract the information of the edge, which solves the problem that the LSD algorithm cannot extract the edge and calculate the orientations accurately in SAR images. Second, the points that have the similar orientations can be grouped by region growing to acquire the line-support regions. Then we use rectangles to fit the parameters of the related lines. Finally, using the Helmholtz principle to validate the rectangles and exclude the false lines. The experiment results show that the modified approach can accurately extract linear feature from SAR images. Compared with the classical method of phase group, the proposed method can compute faster and acquire more reliable performance.
A simple technique for analog tuning of frequency synthesizers (1989)

An analog implementation of the fractional N-phase-locked-loop variable-frequency synthesis technique is presented. In addition to its simplicity, this implementation allows tuning over broad frequency ranges. The synthesizer was developed in response to a need for a compact, low-power, local oscillator for a swept heterodyne, low-frequency, battery-operated, portable spectrum analyzer. The resulting prototype synthesizer was constructed on a 4-in*4-in circuit board using standard CMOS integrated circuits. The total power requirements were +7 V at 8 mA and -7 V at 1 mA when the synthesizer is operated in the 380-580-kHz frequency range. Further reductions in size may be expected from the use of surface mount devices. Spectral data are presented for the prototype circuit serving as the local oscillator in a prototype swept-frequency spectrum analyzer. That is, instead of a spectral analysis of a fixed synthesizer frequency, the synthesizer was swept through a range of frequencies about a stable reference applied to the input of the prototype analyzer. Thus the results are conservative , since they include the effects of noise coupled to the sweep voltage from other circuitry within the prototype analyzer. This method of evaluation demonstrates one of the distinct advantages of this circuit.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
CRYSTALLINE BACTERIAL PROTEINASE (1958)

Journal Article CRYSTALLINE BACTERIAL PROTEINASE: IV. AMINO-TERMINAL AMINO ACID OF CRYSTALLINE BACTERIAL PROTEINASE Get access HIROSHI MATSUBARA, HIROSHI MATSUBARA Department of Biology, Faculty of Science, University of OsakaOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar SHIGEHIKO NISHIMURA SHIGEHIKO NISHIMURA Department of Biology, Faculty of Science, University of OsakaOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 45, Issue 6, June 1958, Pages 413–418, https://doi.org/10.1093/oxfordjournals.jbchem.a126884 Published: 01 June 1958 Article history Received: 02 October 1957 Published: 01 June 1958
Surgical prophylaxis for pulmonary embolism. (1994)

The trauma patient population is at special risk for fatal pulmonary embolism. We experienced 11 fatalities in one 12-month period. Specific risk factors for both deep venous thrombosis and pulmonary embolism can be identified among trauma patients. The latter usually cannot be offered prophylactic anticoagulation, and the nature of their injuries (e.g., long bone fractures) makes not only bedside surveillance difficult but also precludes use of pneumatic compression, etc. We have developed a protocol for prophylactic inferior vena caval filtration for our trauma patients deemed at particular risk for pulmonary embolism. Since 1986 we have inserted 205 Greenfield filters in 201 patients. Two hundred were inserted prophylactically. There was no mortality, and morbidity was minimal. No patient with a Greenfield filter sustained a fatal pulmonary embolism during this period. Four patients died from pulmonary embolism before vena caval filters could be inserted. We believe that the trauma patient, at risk for pulmonary embolism, should be offered a Greenfield filter prophylactically as soon after hospitalization as logistically possible.
The location of binding sites on C1q for DNA. (1990)

Previous studies have suggested that C1q reacts with DNA via both the globular region of C1q (GR) and the collagen-like region of C1q (CLR). In this study, the binding of dsDNA and ssDNA to GR and CLR was quantitated by a solid-phase assay. Both dsDNA and ssDNA bound to the GR and CLR of C1q in an ionic strength-dependent manner. Under physiologic salt concentrations, however, dsDNA and ssDNA bound preferentially to CLR and not to GR. The binding of dsDNA to C1q was not affected by heat inactivation of C1q or its exposure to pH 4.45, which abolished the binding of heat-aggregated human IgG (AHG) with C1q. The preincubation of the solid-phase C1q with AHG did not decrease the binding of dsDNA or ssDNA to the solid-phase C1q. These results indicate that the major sites for binding DNA to C1q are located in the CLR of C1q and are not overlapping with those for AHG or immune complexes.
Knowledge and Situation-Aware Vehicle Traffic Forecasting (2019)

The deep learning revolution, driven especially by incredible achievements in image recognition technology, encourages a predominately data-driven approach to machine learning and data science techniques. However, the emphasis on statistical inference from big data sources alone has diminished the role of existing knowledge and well-established theory. For example, vehicle traffic patterns are highly regular on a weekly period but can deviate unexpectedly in certain situations such as inclement weather, accidents, road work, etc. A purely datadriven approach would simply ask the model to handle all the different situations, while knowledge and situation-aware systems will take advantage of existing knowledge to help guide the machine learning process. This work aims to illustrate how knowledge and situational awareness can help data scientists to build more effective models in the field of vehicle traffic forecasting. The special circumstances considered here include holidays, special weather conditions, accidents, and location awareness that facilitates transfer learning. In addition, we present a novel modeling technique, Quadratic Extreme Learning Machine, that generally improves upon the standard Extreme Learning Machine model while remaining relatively efficient. The Quadratic Extreme Learning Machine can be potentially used as an alternative to Neural Networks, which generally entails higher computational costs.
A STUDY OF SPINAL FLUID PRESSURES IN OPERATIONS REQUIRING REMOVAL OF BOTH INTERNAL JUGULAR VEINS (1952)

New York, N. Y. THE DEPARTMENT OF ANESTHESIOLOGY, MEMORIAL CANCER CENTER, NEW YORK CITY AND THE UNIVERSITY OF BUFFALO, SCHOOL OF MEDICINE, BUFFALO, NEW YORK
The calcium paradox: a reaffirmation. (1975)

Perfusion of isolated rat hearts with a Ca-2+-containing medium, after a Ca2+-free perfusion period, results in an irreversible loss of electrical and mechanical activity of the heart, as well as a large release of intracellular components such as lactate dehydrogenase. These phenomena can be evoked, when hearts are perfused at a constant perfusion pressure or at a constant flow rate. Evidence is provided that recovery of the mechanical activity of the heart is not a requisite for lactate dehydrogenase release.
Dating genomic variants and shared ancestry in population-scale sequencing data (2020)

The origin and fate of new mutations within species is the fundamental process underlying evolution. However, while much attention has been focused on characterizing the presence, frequency, and phenotypic impact of genetic variation, the evolutionary histories of most variants are largely unexplored. We have developed a nonparametric approach for estimating the date of origin of genetic variants in large-scale sequencing data sets. The accuracy and robustness of the approach is demonstrated through simulation. Using data from two publicly available human genomic diversity resources, we estimated the age of more than 45 million single-nucleotide polymorphisms (SNPs) in the human genome and release the Atlas of Variant Age as a public online database. We characterize the relationship between variant age and frequency in different geographical regions and demonstrate the value of age information in interpreting variants of functional and selective importance. Finally, we use allele age estimates to power a rapid approach for inferring the ancestry shared between individual genomes and to quantify genealogical relationships at different points in the past, as well as to describe and explore the evolutionary history of modern human populations.
[Schizoid versus hysterical personality structure. II: Social behavior of precipitating events]. (1986)

38 schizoid and 70 hysterical patients with neurotic disturbances are compared with regard to social data, intelligence and triggering situation. Schizoids are more frequently single, childless and live alone, while hysterics are married, remarried or divorced, have one child and live with their partner and the child. With nearly the same education and intelligence, schizoid patients are more often workers/skilled workers, pupils/apprentices/students or have no profession; hysterically structured individuals, being predominantly women, are more frequently housewives. Nearly half of the most frequent triggering events are equally distributed in both structure groups; these are particularly events signalling a change during development, which, in degree of severity, can just as well be minor threshold situations as serious reverses. With an earlier age of onset, schizoids decompensate significantly more often in "developmental stages", whereas hysterical patients are more likely to do so in connection with events of "love-sexuality" and those which provoke hysterical anxieties. Of the 15 most frequent events, only 6 each occur in either the schizoids (starting school, puberty, moving away from home, entering into a heterosexual relationship in terms of a casual encounter, beginning an apprenticeship or studies, failure in a test) or the hysterically structured individuals (vacation, marriage, pregnancy/delivery, marital disharmony, extra-marital relationship and severe illness of the patient).
TGF‐β regulation of encephalitogenic and regulatory T cells in multiple sclerosis (2017)

Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that has been shown to influence the differentiation and function of T cells. The role that TGF-β plays in immune-mediated disease, such as multiple sclerosis (MS), has become a major area of investigation since CD4<sup>+</sup> T cells appear to be a major mediator of autoimmunity. This review provides an analysis of the literature on the role that TGF-β plays in the generation and regulation of encephalitogenic and regulatory T cells (Treg) in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, as well as in T cells of MS patients. Since TGF-β plays a major role in the development and function of both CD4<sup>+</sup> effector and Treg, which are defective in MS patients, recent studies have found potential mechanisms to explain the basis for these T-cell defects to establish a foundation for potentially modulating TGF-β signaling to restore normal T-cell function in MS patients.
Experimental method of investigating stresses in buttress dams (1959)

A photoelastic method is described for investigating the stress distribution in a buttress dam web of constant thickness, resting on an elastic foundation. The method is also applicable to the stress analysis of a gravity dam. The general case is considered when the elastic properties of the foundations differ from those of the material of the dam. The investigations were made by "frozen-stress" methods in which the composite model of the dam and foundations, together with its impounded liquid, was subjected to a centrifugal acceleration which amplified the body forces and liquid pressures about twenty-eight times. The model was analysed in a polariscope to obtain the difference of the principal stresses and their directions, while the sum of the principal stresses was found from measurements of the lateral extensions of the model. For the latter purpose a new technique was developed.
Catalytic <scp>RNA</scp> (2001)

Abstract Some RNA molecules can function like enzymes and exert a catalytic action on themselves or on other molecules. These ribozymes are diverse in size and sequence and differ in important aspects of their three‐dimensional structure and folding. Catalytic RNAs present a new target for drugs and can be used for inactivating unwanted RNA or DNA molecules by a specific cleavage reaction.
Differences in the nuclease sensitivity between the two alleles of the immunoglobulin kappa light chain genes in mouse liver and myeloma nuclei (1982)

In mouse myeloma T the productive kappa light chain gene differs from its aberrantly rearranged allele in the patterns of DNAase I hypersensitive sites. In the region of the alleles where they are identical in sequence they have one site in common which lies 0.8 kb downstream of the coding region; but two sites upstream of and within the C gene segment (2) are found only on the non-productive allele. Within the region of different sequences both alleles have analogously located DNAase I hypersensitive sites; they lie 0.15 kb upstream of the respective leader segments and cover putative promoter sequences. Only one of the six DNAase I hypersensitive sites is also very sensitive towards micrococcal nuclease due to its particular DNA sequence. The non-rearranged gene studied in liver nuclei has no DNAase I hypersensitive sites but is preferentially cleaved in A/T rich regions.
Towards Deep End-of-Turn Prediction for Situated Spoken Dialogue Systems (2017)

This work was supported by the Cluster of Excellence Cognitive Interaction Technology ‘CITEC’ (EXC 277) at Bielefeld University, funded by the German Research Foundation (DFG), and the DFG-funded DUEL project (grant SCHL 845/5-1).
Correlation of Sagittal Computed Tomography of the Temporomandibular Joint with Surgical Findings (1985)

Ten patients had sagittal computed tomography (CT) done prior to surgery of the temporomandibular joint. The computed tomograms were then compared with the surgical findings and correlated with photographs taken during surgery. Positive correlation was found in all cases between CT and operative findings in assessing disk position and arthritic change. CT was found to be highly accurate for these purposes. The authors believe it to be an excellent adjunctive procedure for patients whose clinical diagnosis is not clear or for patients who do not respond to conservative measures.
Degeneration of a Nonrecombining Chromosome (1994)

Comparative studies suggest that sex chromosomes begin as ordinary autosomes that happen to carry a major sex determining locus. Over evolutionary time the Y chromosome is selected to stop recombining with the X chromosome, perhaps in response to accumulation of alleles beneficial to the heterogametic but harmful to the homogametic sex. Population genetic theory predicts that a nonrecombining Y chromosome should degenerate. Here this prediction is tested by application of specific selection pressures to Drosophila melanogaster populations. Results demonstrate the decay of a nonrecombining, nascent Y chromosome and the capacity for recombination to ameliorate such decay.
Applications of the Phytomedicine<i>Echinacea purpurea</i>(Purple Coneflower) in Infectious Diseases (2011)

Extracts of Echinacea purpurea (EP, purple coneflower) have been used traditionally in North America for the treatment of various types of infections and wounds, and they have become very popular herbal medicines globally. Recent studies have revealed that certain standardized preparations contain potent and selective antiviral and antimicrobial activities. In addition, they display multiple immune-modulatory activities, comprising stimulation of certain immune functions such as phagocytic activity of macrophages and suppression of the proinflammatory responses of epithelial cells to viruses and bacteria, which are manifested as alterations in secretion of various cytokines and chemokines. These immune modulations result from upregulation or downregulation of the relevant genes and their transcription factors. All these bioactivities can be demonstrated at noncytotoxic concentrations of extract and appear to be due to multiple components rather than the individual chemical compounds that characterize Echinacea extracts. Potential applications of the bioactive extracts may go beyond their traditional uses.
Between the Bars (2000)

During my second year of imprisonment on Buru Island, I was among those who had to "ride the Honda," jail slang for coming down with malaria. I felt quite wretched. For about a month after the first attack, I could see no farther than one meter. After the second, I lost sensation in my left leg for about three months.
Enhancing Seed Germination of Sand Blackberry (1988)

Abstract Germination was greater for seeds scarified manually or with 15% NaOCl than for those scarified with concentrated H 2 SO 4 . Fifteen percent NaOCl for 18 hr scarified the seed endocarp and negated the need for stratification. Germination of 85% was attained after 8 weeks incubation in the light at alternating 15°/30°C. This percentage compared favourably with 82% germination resulting from manual scarification techniques. Electron microscopy revealed that endocarp degradation was much more extensive after 18 hr in 15% NaOCl than after 4 days in a 1% solution.