gebhart/patrepeval huggingface dataset:
Sequential translocation of two phenobarbital-induced polysomal messenger ribonucleic acids from the nuclear envelope to the endoplasmic reticulum (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSequential translocation of two phenobarbital-induced polysomal messenger ribonucleic acids from the nuclear envelope to the endoplasmic reticulumFrank J. Gonzalez and Charles B. KasperCite this: Biochemistry 1981, 20, 8, 2292–2298Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/bi00511a034https://doi.org/10.1021/bi00511a034research-articleACS PublicationsRequest reuse permissionsArticle Views23Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reservoir Connectivity: Definitions, Examples, and Strategies (2007)

Reservoir connectivity, and its inverse, compartmentalization,<br>is a critical area of petroleum industry research and business<br>application. However, significant differences in how it is<br>defined, measured, and modeled exist among companies. For<br>some, connectivity is defined relative to an entity such as a<br>well or set of perforations in a reservoir. Others prefer<br>reservoir connectivity indexes, using a set of often<br>subjectively defined criteria to gauge how problematic a field<br>will be to develop or exploit.
Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice (2013)

In the peripheral blood leukocytes (PBLs) from the carriers of the human T-lymphotropic virus type-1 (HTLV-1) or the patients with adult T-cell leukemia (ATL), nuclear factor kappaB (NF-κB)-mediated antiapoptotic signals are constitutively activated primarily by the HTLV-1-encoded oncoprotein Tax. Tax interacts with the I κB kinase regulatory subunit NEMO (NF-κB essential modulator) to activate NF-κB, and this interaction is maintained in part by a molecular chaperone, heat-shock protein 90 (HSP90), and its co-chaperone cell division cycle 37 (CDC37). The antibiotic geldanamycin (GA) inhibits HSP90's ATP binding for its proper interaction with client proteins. Administration of a novel water-soluble and less toxic GA derivative, 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (17-DMAG), to Tax-expressing ATL-transformed cell lines, C8166 and MT4, induced significant degradation of Tax. 17-DMAG also facilitated growth arrest and cellular apoptosis to C8166 and MT4 and other ATL cell lines, although this treatment has no apparent effects on normal PBLs. 17-DMAG also downregulated Tax-mediated intracellular signals including the activation of NF-κB, activator protein 1 or HTLV-1 long terminal repeat in Tax-transfected HEK293 cells. Oral administration of 17-DMAG to ATL model mice xenografted with lymphomatous transgenic Lck-Tax (Lck proximal promoter-driven Tax transgene) cells or HTLV-1-producing tumor cells dramatically attenuated aggressive infiltration into multiple organs, inhibited de novo viral production and improved survival period. These observations identified 17-DMAG as a promising candidate for the prevention of ATL progression.
ChemInform Abstract: Reactions of Terminal Alkynes with cis‐Phenyldiazene, NH=N(C6H5). (1989)

Abstract cis‐Phenyldiazene (II), generated from complex (I), reacts with some substrates such as (III).
The Effect of Vibration on Man and to Ride (1961)

に method of multiple stimuli
Matrix Metalloproteinase-2 in Dentin Matrix Mineralization (2001)

In the serum-free culture medium of bovine odontoblasts we detected active gelatinolytic metalloproteinases, matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases A and B). The activity of MMP-2, in particular, appeared suddenly around day 21 in the culture, coinciding with the development of odontoblastic cell processes and the loss of alkaline phosphatase. Reverse transcriptase-polymerase chain reaction analysis of these odontoblasts demonstrated that messages of MMP-2 but not MMP-9 increased significantly between day 15 and day 21. The in vitro observation indicates that medium conditioned by these odontoblasts and containing significant amounts of MMP-2 degrades not only the collagenous substrates but also purified dentin phosphophoryn as well. We have also observed that dephosphorylated dentin phosphoprotein becomes a better substrate for casein kinase II after limited proteolysis with MMP-2. These results support our working hypothesis that MMP-2-mediated proteolytic processing is an important step in accelerating the process of dentin matrix maturation, which includes phosphorylation and subsequent mineralization. As has been suggested previously, extracellular phosphorylation of matrix proteins is an important step in biomineralization both in bone and in dentin (Mikuni-Takagaki et al., J Bone Miner Res 1995;10:231-42; Zhu et al., Biochem J 1997; 323:637-43). Our present histochemical analysis in MMP-2 knockout mice confirms the concept with the delayed formation of mineralized tissues, dentin, and bone.
Pulmonary microembolism as a cause of acute respiratory failure. (1982)

Clinical and autopsy studies have shown an association between pulmonary microembolism and acute respiratory failure after trauma or sepsis. Prophylaxis and treatment with the aim of decreasing the fibrin deposition in the lungs were associated with a decrease in the incidence and death rate of this syndrome. Small fibrin degradation products (peptides) are accumulated in the lungs and are only slowly cleared from this organ, especially during states of fibrinolysis inhibition. These peptides may contribute to the pulmonary damage in several ways. They act by interfering with other vasoactive substances as bradykinin, histamine and products of the arachidonic acid cascade. Products of the cyclooxygenase pathways as thromboxane A2 play a major role in early microembolism whereas lipoxygenase products seem to be involved in delayed microembolism. Pulmonary microembolism thus seems to be one important, but certainly not the only pathogenetic factor in acute "idiopathic" respiratory failure. Other factors such as pulmonary contusion, aspiration of gastric contents or blood, or oxygen toxicity, might well be contributory in some cases. Pulmonary microemboli containing fibrin and leukocytes are probably also involved as contributory agents in some cases in the large group of acute respiratory failure due to "known factors".
Neutrophil Derived Interference in the Fluorometric Determination of Histamine (1990)

Zymogen-stimulated neutrophils release many pre- and non-preformed factors including proteolytic enzymes, oxygen free radicals and arachidonic acid metabolites. Measurement of the histamine concentration of a supernatant fluid commonly employs an organic extraction procedure followed by condensation to o-phthalaldehyde. Diamine oxidase digestion studies and high-performance liquid chromatographic analysis suggest that a factor(s) derived from zymogen-stimulated neutrophils can produce a positive interference in the fluorometric determination of histamine.
Left-sided Rib Fractures During Cardiopulmonary Resuscitation Are Associated With Better Coronary Perfusion Pressure in a Pig Model of Cardiac Arrest (2015)

International audience
On Consensus of Nonlinear Multi-Agent Systems with Output Constraints (2016)

This paper proposes a unified approach to analyze and synthesize consensus control laws for nonlinear leaderless multi-agent systems (MASs) subjected to output constraints. First, we employ the input-output feedback linearization method to derive the linearized models of agents. Accordingly, the consensus problem under output constraints for the initial nonlinear MAS is transformed into an equivalent consensus problem under state constraints for the linearized MAS, which is then reformulated as a network of Lur’e systems. Next, a sufficient condition for consensus and the design of consensus controller gain are derived from solutions of a distributed LMI convex problem. Finally, a numerical example is introduced to illustrate the proposed theoretical approach.
Source of Protein Supplementation during <i>In Vitro</i> Culture does not Affect the Quality of Resulting Blastocysts in the Domestic Cat (2012)

The objective of this study was to assess and compare the quality of cat blastocysts produced in vitro using commercial blastocyst growth media supplemented with different sources of proteins (serum protein substitute from in vitro maturation through embryo development vs 4 mg/ml of bovine serum albumin for maturation and 5% foetal calf serum for fertilization and embryo development). Impact was specifically examined on the proportion of blastocyst formation, total number of blastomeres, proportion of inner cell mass and expression of pluripotency marker proteins NANOG and OCT-4. Blastocyst formation per total cleaved embryos was similar (p > 0.05) regardless of the protein supplementation. There were no differences (p > 0.05) between culture conditions regarding average number of blastomeres and proportion of inner cell mass in each embryo. Presence of OCT-4 protein was detected in nuclei of both trophectoderm and inner cell mass region, with a stronger signal in the latter regardless of the culture medium. NANOG protein also was present in the inner cell mass regardless of the in vitro culture condition. We therefore demonstrated that serum protein substitute was as good as semi-defined protein sources for the production of good-quality blastocysts and embryonic stem cells. In addition, a single defined medium could be successfully used for cat oocyte maturation, in vitro fertilization and embryo development.
A jumping genes paradigm for the design of wide‐band patch antenna with double shorting wall (2007)

Abstract A newly developed evolutionary computing algorithm, Jumping Genes Evolutionary Algorithm is applied to optimize the dimensions of a folded patch antenna with double shorting walls. In the optimized design, an impedance bandwidth (VSWR ≤2) of 101% is recorded, which shows an improvement by 29% comparing with its original design. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 706–709, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22234
An update to applications of open standards to test automation to board-level testing (2002)

An application of open standard formats to board-level test was described in a paper presented at AUTOTESTCON 1993. This paper provides an update to this work, including descriptions of the problems encountered and solutions developed in applying such standards to two specific printed circuit boards and two automatic test systems (ATSs): the GenRad 2751 and a Modular Automatic Test Equipment (MATE) compatible system. A complete test automation flow process developed around these open standards and data formats is described, including the specific software tools developed, and the input and output requirements of each tool.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Short-period seismic noise structure at the Norwegian Seismic Array (1971)

abstract Power spectral analysis in frequency-wavenumber space and coherence studies in lag space have shown that the noise recorded by the short period Øyer subarray at NORSAR is critically dependent on the weather situation in the North Atlantic Ocean. In addition to the low-frequency noise from the west, there is observed 2-sec microseisms from the Baltic Sea. Because of the nonisotropic noise, the coherence is usually strongly azimuthal dependent, being represented in lag space by ellipses. Large time variations of the coherence are demonstrated.
TNF-α STIMULATES PROTEOLYTIC CLEAVAGE OF THE NEUTROPHIL-EXPRESSED CXCR1 AND CXCR2 CHEMOKINE RECEPTORS THROUGH A NOVEL, LIGAND-INDEPENDENT, METALLOPROTEINASE-DEPENDENT MECHANISM. (1999)

67 Leukocyte migration and infiltration is a central process mediating graft rejection. Pro-inflammatory cytokines, such as TNF-α, regulate the activation and function of leukocytes during immunological responses. Since neutrophils are one of the most predominant cell types that accumulate at sites of transplantation injury, we investigated the molecular mechanisms by which TNF-α regulates neutrophil responsiveness. The neutrophil specific G-protein coupled chemokine receptors, CXCR1 and CXCR2, bind with high affinity to the potent chemoattractant interleukin-8 (IL-8). While the mechanisms of CXC chemokine receptor regulation are not well defined, previous studies have suggested a process of ligand-promoted internalization as a putative regulatory pathway. Herein, we provide evidence for two distinct processes of CXCR1 and CXCR2 regulation. Confocal microscopy data revealed a redistribution of CXCR1 molecules from the cell surface of neutrophils to internal compartments after stimulation with IL-8, whereas stimulation with TNF-α did not induce CXCR1 internalization, but instead, mediated a significant loss of membrane proximal CXCR1 staining intensity. To investigate whether proteolytic cleavage was the mechanism responsible for TNF-α-induced down-modulation of IL-8 receptors, we tested a panel of proteinase inhibitors. The down-modulation of CXCR1 and CXCR2 by TNF-α was most dramatically inhibited by metalloproteinase inhibitors; 1,10-phenanthroline and EDTA significantly attenuated TNF-α-induced loss of CXCR1 and CXCR2 cell surface expression. Metalloproteinase inhibitors also blocked the release of CXCR1 cleavage fragments into the cell supernatants of TNF-α-stimulated neutrophils. In addition, while treatment of neutrophils with TNF-α inhibited IL-8 receptor mediated calcium mobilization and IL-8-directed neutrophil chemotaxis, both 1,10-phenanthroline and EDTA blocked these inhibitory processes. In contrast, metalloproteinase inhibitors did not affect IL-8-mediated down-modulation of CXCR1 and CXCR2 cell surface expression or receptor signaling. These studies provide the first evidence of TNF-α-mediated proteolysis of chemokine receptors and may serve as a basis for the introduction of metalloproteinase inhibitors as a mode for therapeutic intervention of allograft rejection. This work was funded in part by MRC of Canada and the Heart and Stroke Foundation of Canada.
Extrarenal Manifestations of Renal Cell Carcinoma (1977)

Renal cell adenocarcinoma can be one of the great masqueraders in medicine. More common extrarenal manifestations of renal cell carcinoma include fever, anemia and gastrointestinal symptoms. Other rarer systemic symptoms are caused by amyloidosis, neuromyopathy and tumor thrombus. Humoral manifestations include polycythemia, hypercalcemia, galactorrhea and Cushing's syndrome. Metastatic disease commonly presents as the initial symptom.
Preparation of c-Axis Oriented La<sub>2</sub>CuO<sub>4</sub>Thin Films on the Si Substrate by Pulsed Laser Deposition (2008)

The parent materials of the first high-TC cuprate, La2CuO4 (LCO) are known to be correlated with Mott insulators that become metallic and superconducting upon doping with charge carriers. 1 A large number of researches have been performed on bulk samples in the LCO-based materials due to their simple chemical composition and crystal structures as well as the rich physical properties. 2 The transition from the Mott-Hubbard insulating state to the metallic state is called the metal insulator transition (MIT), 3 and is a topic of great current interest. As an important application of the MIT, a high-speed Mott switching device using an abrupt current jump was predicted for a transistor. 4 LCO is known to have three different structures, 5 T-phase (K2NiF4-type) containing edge-shared CuO6 octahedra arranged in a planar array, T’-phase (Nd2CuO4-type) in which the apical oxygen in the T-phase is shifted away from the Cu atoms, and S-phase (Sr2CuO3) which has isolated CuO3 chains running along the a-axis of the orthorhombic structure. Transitions among T, T’ and S phases were found in the annealing process of bulk LCO. These are quasi-two-dimensional materials which consist of layers of copper-oxide planes separated. It seems that most of the properties are determined by electrons moving within CuO2 planes. The preparation of the thin film 6 is a key point to develop the devices such as thermal switching, thermochromatic coatings, non-volatile memory etc. applying MIT properties of LCO. High quality thin film of LCO is required for a variety of fundamental studies. The electrical and transport properties of LCO-based thin films are highly sensitive to the degree of c-axis orientation in the film growth and induced strain due to lattice mismatch with the substrate. A large number of substrates have been used to obtain highly oriented LCO thin films with good electrical properties such as NdGaO3, LaALO3, SrTiO3, and SrLaAlO3 substrates with a small lattice mismatch. 7 However, these cannot be used in the development of the MIT devices as common substrates because it is too difficult and expensive for the preparation of their single crystalline structure. LCO thin film is required to be grown with c-axis orientation on the surface of common substrates such as SiO2 acting as a gate oxide for fabrication of MIT devices. In the present work, we report the first preparation of caxis oriented LCO thin films on Si substrate, which is largely lattice-mismatched with LCO, by pulsed laser deposition (PLD) following in-situ post-annealing in oxygen ambient. PLD technique is a well-known deposition technique providing stoichiometric transfer of target materials via congruent evaporation for a wide range of materials including metals, alloys and oxide films.
<title>Compact piezohydraulic actuation system</title> (2000)

Design and analysis of a scalable piezohydraulic actuation system is presented. Efficiency analysis of frequency rectification demonstrates that hydraulic actuation transfers the maximum amount of work from the actuator to the load. The ratio of peak electrical power to average power delivered caries from 8 percent to 25 percent depending on the piezoelectric coupling coefficient, highlighting the need for efficient power electronics to minimize heat dissipation in the system and minimize volume. A lumped parameter system model demonstrates that fluid compliance is the limiting facto in the stiffness of a bidirectional actuator that does not require hydraulic accumulators or four-way valves. A benchtop experiment consisting of a piezoelectric shock actuator, pumping chamber, and a linear hydraulic cylinder is developed and tested to determine the effect of friction on the micron- level motion of the actuator. The effects of friction are minimized by applying a pneumatic precharge to the system and driving the actuator at its maximum voltage level. Friction is not deemed a limiting factor to the development of a piezohydraulic system with stroke outputs on the order of 100 micrometers per cycle.
Clonage de l'ADNc codant pour le protéolipide majeur de la myéline : contribution à la caractérisation de la DM-20 et du mutant Jimpy (1988)

In the central nervous system, the major protein of the myelin sheath is integral membrane protein designated proteolipid protein or PLP. To reveal primary structure and to understand abnormalities associated with it, we undertaken the construction of a rat brain Edna library. A 14-base synthetic oligonucleotide based on a sequence derived from an internal peptide of rat PLP, was used as an hybrization probe to select for recombinant ids bearing the PLP sequence. One positively hybridizing clone, which contained a 1335 nucleotide cDNA insert, was subjected to DNA sequence analysis by the dideoxy method. The nucleotide sequence contained an open reading frame coding for the complete 276 amino acid residues sequence beginning with the known NH2-terminal sequence. The first ATG encountered for Met (-1) lies within a favorable consensus sequence for functional initiators. PLP appears to have been remarquably conserved during evolution, only two differences found between rodent, bovine or human sequences. This cDNA recognizes at least two mRNAS of 3. 2 kb and 1. 6 kb, but southern genomic blots indicate that the PLP gene is present only once per haploid genome. By in situ hybridization, the gene was localized to the X chromosome of both human (Xq22) and mouse (XF1). It was suspected that PLP might be the t of the X-linked jimpy (jp) locus of the mouse. By restriction fragment length polymorphism (RFLP), the PLP gene was localized closely to the same region to which jimpy had been mapped. Sl nuclease protection analysis revealed that the PLP mRNA from jp/Y mice carries a deletion corresponding to C-terminal part of the protein. A sex-linked human dysmyelinization disease (PELIZAEUS-MERZBACHER disease) could be similar to this mutation. Subsequently Sl mapping revealed an mRNA coding for the proteolipid DM-20 which differs PLP by a 35 amine acid long internal deletion between valine 116 and lysine 150. By computer searches, we report molecular mimicry between viral antigens and sequences in PLP. These homologies could be responsible of autoimmunization processes
Synthesis and laboratory testing of a novel calcium-phosphonate reverse micelle nanofluid for oilfield mineral scale control (2016)

Developed calcium-phosphonate scale inhibitor reverse micelle nanomaterial for oilfield mineral scale control in low water cut or water sensitive wells.
Inexpensive implementations of set-associativity (1989)

The traditional approach to implementing wide set-associativity is expensive, requiring a wide tag memory (directory) and many comparators. Here we examine alternative implementations of associativity that use hardware similar to that used to implement a direct-mapped cache. One approach scans tags serially from most-recently used to least-recently used. Another uses a partial compare of a few bits from each tag to reduce the number of tags that must be examined serially. The drawback of both approaches is that they increase cache access time by a factor of two or more over the traditional implementation of set-associativity, making them inappropriate for cache designs in which a fast access time is crucial (e.g. level one caches, caches directly servicing processor requests). These schemes are useful, however, if (1) the low miss ratio of wide set-associative caches is desired, (2) the low cost of a direct-mapped implementation is preferred, and (3) the slower access time of these approaches can be tolerated. We expect these conditions to be true for caches in multiprocessors designed to reduce memory interconnection traffic, caches implemented with large, narrow memory chips, and level two (or higher) caches in a cache hierarchy.
Myelography in the Evaluation of Paravertebral Mass Lesions in Infants and Children (1976)

The clinical, pathological, and radiological features in 21 pediatric patients with intraspinal extension may be present in the absence of either neurological symptoms or bony abnormalities. It is essential that myelography be performed prior to thoractomy or laparotomy in such cases.