gebhart/patrepeval huggingface dataset:
Towards integrated optical quantum networks in diamond (2012)

We demonstrate coupling between the zero phonon line (ZPL) of nitrogen-vacancy centers in diamond and the modes of optical micro-resonators fabricated in single crystal diamond membranes sitting on a silicon dioxide substrate. A more than ten-fold enhancement of the ZPL is estimated by measuring the modification of the spontaneous emission lifetime. The cavity-coupled ZPL emission was further coupled into on-chip waveguides thus demonstrating the potential to build optical quantum networks in this diamond on insulator platform.
Studies of temporal stability of poled nonlinear optical polymer films (2006)

Guest-host polymer system with potential use in electro-optic devices is discussed. The polymer host is a polyimide and the guest chromophore is Disperse Red 19 (DR 19). Decay times of poled order after corona poling procedure have been derived from the behaviour at elevated temperatures below glass transition temperature T<sub>g</sub> using Arrhenius plots. An extrapolated lifetime greater than 30 years at room temperature has been obtained.
Preparation of 3,4,5-Trisubstituted Pyrazoles from 2,2-Dioxoketene-S,S-acetals (1977)

2,2-Dioxoketene-S,S-acetals (5-7) react with hydrazine to give 5-methylthiEpyrazoles (8-10) rather than diazafulvenes (A).Nucleo-p5iEc displacement of the 5-methylthio (or the derived 5-methylsulfonyl) substituent in these pyrazoles was not possible.
Abstract 397: SMARCA4 is a selective vulnerability in SMARCA2-deficient esophageal squamous cell carcinoma cell lines (2019)

Esophageal squamous cell carcinoma (ESCC) is a highly prevalent tumor type with poor prognosis and limited treatment options. In this study, we aimed to discover potential novel drug targets using a pooled epigenome sgRNA viability screen in a panel of ESCC cell models. We identify the BAF chromatin remodeling helicase subunit SMARCA4/BRG1 as a novel dependency in a subset of ESCC cell lines. In line with the established synthetic lethal interaction of SMARCA4 and SMARCA2/BRM, the two mutual exclusive catalytic subunits of the BAF complex, SMARCA4-dependent cell lines display low or absent expression of SMARCA2. In rescue studies using SMARCA4 variants, we demonstrate that SMARCA4-dependency is linked to its ATPase/helicase activity, but not to bromodomain function. Similarly, ectopic expression of wild-type and bromodomain-mutant SMARCA2, but not a helicase-dead variant, rescues from loss of SMARCA4 in SMARCA2-low ESCC cells. SMARCA2-proficient ESCC cell models are rendered SMARCA4-dependent upon CRISPR/Cas9-mediated knock-out of SMARCA2. We further identify SMARCA4-dependent cell models from additional tumor types (colon, ovarian and pancreas carcinoma) with low or absent SMARCA2 expression. These findings expand the concept of SMARCA2/SMARCA4 paralog dependency and indicate pharmacological inhibition of SMARCA4 as a novel opportunity for targeted therapy of SMARCA2-deficient cancers.Citation Format: Katharina Ehrenhöfer-Wölfer, Teresa Puchner, Silvia Blaha-Ostermann, Alexandra Hörmann, Wolfgang Sommergruber, Norbert Schweifer, Thomas Zichner, Andreas Schlattl, Ralph A. Neumüller, Manfred Koegl, Mark P. Petronczki, Mark Pearson, Simon Wöhrle. SMARCA4 is a selective vulnerability in SMARCA2-deficient esophageal squamous cell carcinoma cell lines [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 397.
Anticollagen antibodies and immune response gene products in rheumatoid arthritis (1984)

Circulating antibodies to native and denatured types I and II human and bovine collagens were assayed in patients with rheumatoid arthritis (RA), patients with other rheumatic diseases, and normal individuals. A subgroup of this population was also assayed for reactivity with typing reagents which detect determinants (MT and HLA-DR) present in human immune response gene products. The mean titers of antibodies to each collagen tested were not significantly higher in RA patients when compared with patients who had other rheumatic diseases. Although both MT3 and MT4 were significantly associated with RA, there was no significant association between the anticollagen antibodies and any MT type or HLA-DR4. These studies raise a question concerning the role of collagen antibodies in the pathogenesis of RA and suggest that genes distinct from those coding for HLA-DR may play a role in the expression of the disease.
Semicontinuous Method for Monitoring SO2 at Low Parts-per-Trillion Concentrations (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSemicontinuous Method for Monitoring SO2 at Low Parts-per-Trillion ConcentrationsDavid E. Schorran, Clarence. Fought, David F. Miller, William G. Coulombe, Robert E. Keislar, Richard. Benner, and Donald. StedmanCite this: Environ. Sci. Technol. 1994, 28, 7, 1307–1311Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://doi.org/10.1021/es00056a019RIGHTS & PERMISSIONSArticle Views50Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (634 KB) Get e-Alerts Get e-Alerts
SU‐E‐J‐214: MR Protocol Development to Visualize Sirius MRI Markers in Prostate Brachytherapy Patients for MR‐Based Post‐Implant Dosimetry (2015)

Purpose: The current CT‐based post‐implant dosimetry allows precise seed localization but limited anatomical delineation. Switching to MR‐based post‐implant dosimetry is confounded by imprecise seed localization. One approach is to place positive‐contrast markers (Sirius) adjacent to the negative‐contrast seeds. This patient study aims to assess the utility of a 3D fast spoiled gradient‐recalled echo (FSPGR) sequence to visualize Sirius markers for post‐implant dosimetry. Methods: MRI images were acquired in prostate implant patients (n=10) on Day 0 (day‐of‐implant) and Day 30. The post‐implant MR protocol consisted of 3D T2‐weighted fast‐spin‐echo (FSE), T2‐weighted 2D‐FSE (axial) and T1‐weighted 2D‐FSE (axial/sagittal/coronal). We incorporated a 3D‐FSPGR sequence into the post‐implant MR protocol to visualize the Sirius markers. Patients were scanned with different number‐of‐excitations (6, 8, 10), field‐of‐view (10cm, 14cm, 18cm), slice thickness (1mm, 0.8mm), flip angle (14 degrees, 20 degrees), bandwidth (122.070 Hz/pixel, 325.508 Hz/pixel, 390.625 Hz/pixel), phase encoding steps (160, 192, 224, 256), frequency‐encoding direction (right/left, anterior/posterior), echo‐time type (minimum‐full, out‐of‐phase), field strength (1.5T, 3T), contrast (with, without), scanner vendor (Siemens, GE), coil (endorectal‐coil only, endorectal‐and‐torso‐coil, torsocoil only), endorectal‐coil filling (30cc, 50cc) and endorectal‐coil filling type (air, perfluorocarbon [PFC]). For post‐implant dosimetric evaluation with greater anatomical detail, 3D‐FSE images were fused with 3D‐FSPGR images. For comparison with CT‐based post‐implant dosimetry, CT images were fused with 3D‐FSPGR images. Results: The 3D‐FSPGR sequence facilitated visualization of markers in patients. Marker visualization helped distinguish signal voids as seeds versus needle tracks for more definitive MR‐based post‐implant dosimetry. On the CT‐MR fused images, the distance between the seed on CT to MR images was 3.2±1.6mm in patients with no endorectal coil, 2.3±0.8mm in patients with 30cc‐PFC‐filled endorectal‐coil and 5.0±1.8mm in patients with 50cc‐PFC‐filled endorectal‐coil. Conclusion: An MR protocol to visualize positive‐contrast Sirius markers to assist in the identification of negative‐contrast seeds was demonstrated. S Frank is a co‐founder of C4 Imaging LLC, the manufacturer of the MRI markers.
Facile Rearrangement of<i>O</i>-Silylated Oximes on Reduction with Boron Trifluoride/Borane (2005)

[reaction: see text] Aromatic O-triisopropylsilyl ketoximes were efficiently rearranged to cyclic and acyclic aniline derivatives on reduction with BF3-ethearate/borane. The bulk of the substituents on the silicon atom, the size of the aliphatic ring, and the presence of alkoxy substituents on the aryl group all play an important role in the aniline.
<b><i>MLL-SEPT5</i></b>fusion transcript in infant acute myeloid leukemia with t(11;22)(q23;q11) (2013)

Chromosomal rearrangements involving the MLL gene at band 11q23 are the most common genetic alteration encountered in infant acute myeloid leukemia. Reciprocal translocation represents the most frequent form of MLL rearrangement. Currently, more than 60 partner genes have been identified. We report here a case of de novo acute myeloid leukemia with a t(11;22)(q23;q11) in a 23-month-old child. Fluorescence in situ hybridization study revealed that the 3'MLL segment was translocated onto the derivative chromosome 22 and the breakpoint on chromosome 22 was located in or near the SEPT5 gene at 22q11.21. Long distance inverse-polymerase chain reaction was used to identify precisely the MLL partner gene and confirmed the MLL-SEPT5 fusion transcript. Involvement of the SEPT5 gene in MLL rearrangement occurs very rarely. Clinical, cytogenetic and molecular features of acute myeloid leukemia with a MLL-SEPT5 fusion gene are reviewed.
Observability analysis of piece-wise constant systems. I. Theory (1992)

For pt.II see ibid., vol.28, no.4, p.1068-75, Oct. 1992. A method for analyzing the observability of time-varying linear systems which can be modeled as piece-wise constant systems (PWCS) is presented. An observability matrix for such systems is developed for continuous and discrete time representations. A stripped observability matrix (SOM) is introduced which simplifies the analysis in cases where the use of this matrix is legitimate. The observability analysis is presented as a step-by-step procedure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Coordinated operation of HVDC and FACTS (2002)

Over the course of three decades of commercial applications, the HVDC technique has been established as a conventional technology in the area of back-to-back and two-terminal long-distance and submarine cable systems up to 2000 MW and higher. As thyristor-controlled shunt compensation schemes have been introduced into high-voltage transmission for more than two decades, FACTS (flexible AC transmission systems) devices are established as technical and economic means for improving the overall system performance of AC systems. Today, only limited HVDC and FACTS systems are operated in a coordinated manner. However, with increasing complexity of system conditions, e.g. in very weak power systems with enhanced stability requirements, parallel operation of HVDC and FACTS devices is gaining impetus. Innovative technologies can further optimize the HVDC performance under weak and very weak system conditions.
Intermittent fever in a patient with apparent fatty liver: Figure 1 (2006)

Caso quiz epatologico radiologico dove la diagnosi si fonda su anmnesi accurata e attenta interpretazione della semeiotica RM
In vivo expression of the insulin‐like growth factor‐I (IGF‐I) receptor in congenital pigmented nevi (1996)

Growth of normal melanocytes, nevus cells and primary melanoma cells is enhanced by insulin/insulin-like growth factor-I (IGF-I) in vitro. It has been shown that a melanoma cell line possesses the IGF-I receptor which plays a role in activation of the chemotactic response. Little is known about the in vivo expression of the IGF-I receptor and its role in melanocytic lesions. In an immunohistochemical study, we investigated the expression of IGF-I receptor in frozen sections of congenital pigmented nevi from 10 patients (ages 8 months to 4 yrs) using the monoclonal antibody alpha IR3, which specifically recognizes the extracellular alpha subunit of the IGF-I receptor. The proliferative activity of the nevus cells was examined by staining with Ki67 monoclonal antibody (reactive with all actively cycling cells). IGF-I receptor was found to be widely expressed by the cell surface of the nevus cells. Membrane staining was occasionally stronger in the superficial portion of the congenital pigmented nevi. In contrast, Ki67-positive cells were only sparsely scattered throughout the nevi with some tendency to localization to the superficial portion. This study indicates that in vivo the IGF-I receptor is widely expressed by congenital pigmented nevus cells. As opposed to keratinocytes, in which IGF-I receptor expression defines the proliferation pool of the normal and disordered epidermis, the IGF-I receptor is expressed by all nevus cells, irrespective of their proliferative status. Further studies are needed to assess whether the IGF-I receptor expression can serve as a marker for increased risk for development of malignancy in various types of benign melanocytic lesions.
Comparison of Defibrillation Efficacy Using Biphasic Waveforms Delivered from Various Capacitances/Pulse Widths (1997)

The efficacy of the biphasic waveform shock for the defibrillation of the ventricular myocardium has been reported by researchers and physicians. Although many authors have suggested that biphasic waveforms delivered from lower capacitances and shorter pulse widths could result in the reduction of the energy required for successful defibrillation, no report has described the smallest capacitance and pulse width yielding the lowest DFT. In this study, we compared efficacies of the biphasic waveform shocks and DFT safety margins among five different capacitances (175 mu f, 125 mu f. 100 mu f. 75 mu f, and 50 mu f) combined with 1-3 pulse widths. These experiments performed in six dogs used an endocardial lead/subcutaneous patch defibrillation electrode system. The average DFTs at E50 for 175 mu f (6.5/3.5 ms), 125 mu f (6.5/3.5 ms), 100 mu f (6.0/3.0 ms), 75 mu f (4.0/2.0) ms, and 50 mu f (3.0/2.0 ms) were 8.5, 10.0, 11.0, 14.0, and 16.5), respectively. These results indicate that a biphasic waveform delivered from a larger capacitance with a proper pulse width could achieve a higher defibrillation efficacy. All DFTs at E50 for all waveforms were compared to their deliverable energies and maximum stored energies. This comparison indicated a narrow DFT safety margin with capacitances below 100 mu f. Therefore, it is concluded that higher energy and higher leading edge voltage are required for a biphasic waveform delivered from a smaller capacitance with a shorter pulse width. Since the current capacitor technology provides a maximum voltage of 750 V using two capacitors in series, with the electrode impedance system used in this study, smaller capacitors appear to have a decreased probability of defibrillation success at a given energy.
Relative effects of flow and orientation on the critical heat flux in subcooled forced convection boiling (1995)

The intent of this study is to clarify the relative significance of buoyancy and bulk flow inertia forces to the critical heat flux (CHF) in forced convection boiling, which will also serve to enhance the understanding of the CHF in microgravity, where buoyancy effects are absent. Measurements of the CHF in subcooled forced convection boiling of R113 were obtained over a flat copper heater surface at varying orientations with respect to gravity for low flow velocities, where buoyancy is substantial relative to the flow forces. In addition, an analytical model describing the effects of the flow velocity, heater orientation and subcooling was developed, relying partly on empirical relationships derived from hot wire anemometer measurements of the void fraction and bubble frequency. The forced convection boiling experiments were conducted for various subcoolings ranging from $2.8\sp\circ\rm C$ to $22.2\sp\circ\rm C,$ bulk flow velocities ranging from 4 cm/s to 55 cm/s and heater orientations spanning 360 degrees. Included with the CHF measurements are bubble frequency and void fraction measurements for downward facing orientations at various locations tangent and normal to the heater surface. A semi-transparent gold film heater on a quartz substrate was also used to permit high speed photography of the boiling process from beneath the heater surface, unencumbered by the vapor formed on the surface. The experiments show that the CHF is a strong function of the heater surface orientation at very low flow velocities, and that orientation has a considerable effect on the CHF for flow velocities below 55 cm/s. In orientations where the buoyancy and flow forces oppose each other, the CHF is generally much lower than in orientations where they act in the same direction, owing to the increase in time during which the bubbles are resident at the heater surface. The analytical model of the CHF considers the motion of the larger bubbles on the heater surface, relating the inverse of the bubble residence time to the CHF. The model also includes the effects of subcooling, which act to reduce the net vapor generation rate, thereby deferring the onset of the CHF to higher levels of heat flux.
Effect of Delayed Hypoglossal-facial Nerve Anastomosis on the Facial Nerve Regeneration in the Rat (2002)

Guntinas-Lichius, O; Rüger, M A.; Pechuel-Loesche, S; Effenberger, C; Angelov, D N.; Neiss, W F.; Streppel, M; Stennert, E Author Information
Direkte zytotoxische Effekte des Hepatitis B Virus Oberflächenproteins in der Leber (2013)

Einleitung: Zirrhose und hepatozelluläres Karzinom sind die wichtigsten Ursachen für Morbidität und Mortalität bei Hepatitis B (HBV) Infektionen. Obwohl sehr detaillierte Daten über die immunvermittelte Schädigung HBV infizierter Hepatozyten vorliegen, ist nur sehr wenig über die direkten pathogenen Effekte des HBV Oberflächenproteins bekannt. Mit der vorliegenden Studie wurden pathologische Effekte des HBV Oberflächenproteins in der Leber transgener Mäuse analysiert.
Contributors (1966)

Contains an entry for each author and co-author included in this publication.
Does soil determine the boundaries of monodominant rain forest with adjacent mixed rain forest and maquis on ultramafic soils in New Caledonia? (2006)

Abstract Aim To determine the soil characteristics of Nothofagus ‐dominated rain forests in an ultramafic region (i.e. soils having high concentrations of metals including Mg, Fe and Ni), and whether soil characteristics may explain the location of monodominant rain forest in relation to adjacent mixed rain forest and maquis (shrub‐dominated vegetation). Location New Caledonia. Methods Soil characteristics were compared among six Nothofagus ‐dominated rain forests from a range of altitudes and topographic positions. At four of these sites, comparisons were made with soils of adjacent mixed rain forest and maquis. Results Soil characteristics varied among the monodominant Nothofagus forests, largely due to differences between ultramafic soils and soils influenced by non‐ultramafic intrusions. The soils of all vegetation types had low concentrations of nutrients, particularly P, K and Ca (both total and extractable/exchangeable), and high total concentrations of Ni, Fe, Cr and Mn. There were significant differences between the rain forests and adjacent maquis in soil concentrations of several elements (N, P, Ca, Mg and Mn), more so in surface soils than at depth, but much of this pattern may be caused by effects of vegetation on the soil, rather than of soil on the vegetation. However, there were no significant differences in soil concentrations of any mineral elements between Nothofagus forest and adjacent mixed rain forest. Main conclusions We found no evidence for soil mediation of boundaries of Nothofagus rain forest with mixed rain forest, and little evidence for the boundaries of either forest type with maquis. We suggest that the local abrupt boundaries of these monodominant Nothofagus forests are directly related to temporal factors, such as time since the last wildfire and frequency of wildfire, and that disturbance is therefore a major causal factor in the occurrence of these forests.
Bandwidth extension for dipole antennas by conjugate reactance loading (1971)

Periodically loaded transmission line theory is employed to indicate a loading scheme for broad banding a linear dipole antenna. A conjugate reactance load element (negative inductance) is suggested and a design concept developed. Numerical techniques are used to solve Hallen's integral equation, and it is shown that a broad-band (8:1 frequency range) dipole with broadside radiation and VSWR < 2 can be realized.
Biomechanical Assessment of Soft Tissue Neck Injuries in Cases with Long Sick Leave Times (2003)

A database was established by collecting 919 cases of claimed cervical spine disorders (CSDs) sustained in automotive accidents. All cases had a sick leave time of more than 4 weeks. Data was obtained from a major Swiss accident insurer. An assessment scheme was developed that took into account technical, medical, and biomechanical aspects. All cases were evaluated according to this scheme. The overall biomechanical assessment, that stated the extent to which the symptoms claimed could be explained by the impact, was found to be significantly influenced by the patient's history of CSD in terms of preexisting damage or preexisting symptoms. In 52% of the assessed cases, the CSD claimed could be explained with a combination of neck loading and also by considering the patient's medical history. Performing a solely technical analysis of the collision circumstances or a purely medical evaluation based on a Quebec Task Force (QTF) grade alone are insufficient to assess the accident-related explicability of claimed CSD. Biomechanically relevant individual factors have to be considered.
Ester cleavage by a phenolic quaternary phosphonium surfactant (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEster cleavage by a phenolic quaternary phosphonium surfactantDavid A. Jaeger and Durgadas BolikalCite this: J. Org. Chem. 1986, 51, 8, 1352–1354Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/jo00358a037https://doi.org/10.1021/jo00358a037research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts