gebhart/patrepeval huggingface dataset:
Photoacoustic infrared spectroscopy of doped and undoped poly(p-phenylene) (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoacoustic infrared spectroscopy of doped and undoped poly(p-phenylene)Stuart I. Yaniger, David J. Rose, William P. McKenna, and Edward M. EyringCite this: Macromolecules 1984, 17, 12, 2579–2583Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/ma00142a020https://doi.org/10.1021/ma00142a020research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of Divalent Cations on Deformation and Rupture of Adsorbed Lipid Vesicles (2016)

The fate of adsorbed lipid vesicles on solid supports depends on numerous experimental parameters and typically results in the formation of a supported lipid bilayer (SLB) or an adsorbed vesicle layer. One of the poorly understood questions relates to how divalent cations appear to promote SLB formation in some cases. The complexity arises from the multiple ways in which divalent cations affect vesicle-substrate and vesicle-vesicle interactions as well as vesicle properties. These interactions are reflected, e.g., in the degree of deformation of adsorbed vesicles (if they do not rupture). It is, however, experimentally challenging to measure the extent of vesicle deformation in real-time. Herein, we investigated the effect of divalent cations (Mg(2+), Ca(2+), Sr(2+)) on the adsorption of zwitterionic 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid vesicles onto silicon oxide- and titanium oxide-coated substrates. The vesicle adsorption process was tracked using the quartz crystal microbalance-dissipation (QCM-D) and localized surface plasmon resonance (LSPR) measurement techniques. On silicon oxide, vesicle adsorption led to SLB formation in all cases, while vesicles adsorbed but did not rupture on titanium oxide. It was identified that divalent cations promote increased deformation of adsorbed vesicles on both substrates and enhanced rupture on silicon oxide in the order Ca(2+) > Mg(2+) > Sr(2+). The influence of divalent cations on different factors in these systems is discussed, clarifying experimental observations on both substrates. Taken together, the findings in this work offer insight into how divalent cations modulate the interfacial science of supported membrane systems.
An evaluation of how NO2, NO, O3 and relative humidity interacts in the oxidation of terpenes (2002)

An evaluation of how NO2, NO, O3 and relative humidity interacts in the oxidation of terpenes
Expression of herpes virus thymidine kinase in Neurospora crassa (1997)

The expression of thymidine kinase in fungi, which normally lack this enzyme, will greatly aid the study of DNA metabolism and provide useful drug-sensitive phenotypes. The herpes simplex virus type-1 thymidine kinase gene ( tk ) was expressed in Neurospora crassa. tk was expressed as a fusion to N.crassa arg-2 regulatory sequences and as a hygromycin phosphotransferase-thymidine kinase fusion gene under the control of cytomegalovirus and SV40 sequences. Only strains containing tk showed thymidine kinase enzyme activity. In strains containing the arg-2 - tk gene, both the level of enzyme activity and the level of mRNA were reduced by growth in arginine medium, consistent with control through arg-2 regulatory sequences. Expression of thymidine kinase in N.crassa facilitated radioactive labeling of replicating DNA following addition of [3H]thymidine or [14C]thymidine to the growth medium. Thymidine labeling of DNA enabled demonstration that hydroxyurea can be used to block replication and synchronize the N.crassa mitotic cycle. Strains expressing thymidine kinase were also more sensitive than strains lacking thymidine kinase to anticancer and antiviral nucleoside drugs that are activated by thymidine kinase, including 5-fluoro-2'-deoxyuridine, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouridine and trifluorothymidine. Finally, expression of thymidine kinase in N. crassa enabled incorporation of bromodeoxyuridine into DNA at levels sufficient to separate newly replicated DNA from old DNA using equilibrium centrifugation.
Accent identification (2002)

Foreign accent identification is a new challenging problem closely related to other relatively recent fields of the multilingual area such as dialect identification and language identification. The paper describes an automatic identification system for English accents from 6 different European countries. The approach is based on a parallel set of ergodic nets with context independent HMM units. The ergodic topology was also substituted by pronunciation transcription constraints in order to integrate accent specific automatic word recognisers. Considering the complexity of the task, the results can be considered encouraging for further research.
Prolonged administration of granulocyte colony-stimulating factor (filgrastim) to patients with Fanconi anemia: a pilot study (1996)

This report examines the effect of filgrastim (granulocyte colony-stimulating factor, [G-CSF] in 12 patients with neutropenia [absolute neutrophil count [ANC] < 1,000/mm3]) caused by Fanconi anemia (FA). Two of 14 patients who were evaluated for study entry were ineligible because of unsuspected cytogenetic abnormalities in their bone marrow (BM). G-CSF was started at 5 micrograms/kg/d. All patients had an increase in their ANC at week 8 (mean increase = 15,664/mm3). The median ANC during therapy was 5,030/mm3. Eight of 10 patients who completed 40 weeks on study maintained an ANC > 1,500/mm3 on G-CSF given every-otherday. Four patients had an increase in their platelet count by week 8 without transfusion (maximum increase = 23,000 to 45,000/mm3); however, platelet counts fell toward baseline levels as the G-CSF dose was reduced. BM CFU-MK were increased at week 8 in three of four evaluable patients. Four patients who did not receive red blood cell transfusions had an increase in their hemoglobin level of at least 2.0 g/dL. A fifth patient had a red blood cell transfusion in week 2 and then had a similar increase in hemoglobin level without subsequent transfusion. Eight of 10 patients who completed 40 weeks of treatment showed increases in the percentage of BM CD34+ cells measured by flow cytometry. The same proportion showed increases in peripheral blood CD34+ cells. Increased BM cellularity and myeloid hyperplasia were constant findings and were associated with increased expression of the proliferating cell nuclear antigen. Adverse experiences were mild fever (1 patient) and a new BM cytogenetic abnormality at week 40 (1 patient). This study shows that prolonged administration of G-CSF exerts a stimulatory effect on the BM of FA patients and may be used to maintain a clinically adequate ANC in these patients. G-CSF has beneficial effects on multiple hematopoietic lineages in some patients and may be a good candidate for use in combination cytokine protocols for FA patients with progressive aplastic anemia. G-CSF use results in an increase in circulating CD34+ cells, a finding with important implications for future gene transfer protocols.
Langmuir Decay Instability Cascade in Laser-Plasma Experiments (2002)

Thomson scattering has been used to investigate the nonlinear evolution of electron plasma waves (EPWs) generated by stimulated Raman scattering (SRS). Two complementary diagnostics demonstrate the occurrence of the cascade of Langmuir decay instabilities (LDI). The EPW wave-number spectrum displays an asymmetric broadening towards small wave numbers, interpreted as a signature of the secondary EPWs produced in the LDI cascade. The number of cascade steps is in agreement with the broadening of the associated ion-acoustic-waves' spectra. The total energy transferred in the EPWs cascade is found to be either less than or of the same order of magnitude as the energy of the primary EPW.
Use of achiral shift reagents to indicate relative stabilities of diastereomeric solvates (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of achiral shift reagents to indicate relative stabilities of diastereomeric solvatesWilliam H. Pirkle and David L. SikkengaCite this: J. Org. Chem. 1975, 40, 23, 3430–3434Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/jo00911a028https://doi.org/10.1021/jo00911a028research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A novel type of spiro compound formed by oxidative cross coupling of methyl sinapate with a syringyl lignin model compound. A model system for the β-1 pathway in lignin biosynthesis (1999)

Oxidative coupling of methyl (E)-sinapate with 1-(4-hydroxy-3,5-dimethoxyphenyl)ethanol, a syringyl lignin model compound, was carried out with hydrogen peroxide catalyzed by horseradish peroxidase. The main product was a cyclohexadienone spiro compound of a novel type. Mild acidolysis caused the loss of one side chain and yielded a dimeric compound with a 1,2-diarylpropane structure. This is the first example of the formation of this structural type by oxidative coupling in vitro.
Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines (2011)

Gli1 is an established oncogene and its expression in Estrogen Receptor (ER) α negative and triple negative breast cancers is predictive of a poor prognosis; however, the biological functions regulated by Gli1 in breast cancer have not been extensively evaluated. Herein, Gli1 was over-expressed or down-regulated (by RNA interference and by expression of the repressor form of Gli3) in the ERα negative, human breast cancer cell lines MDA-MB-231 and SUM1315. Reduced expression of Gli1 in these two cell lines resulted in a decrease in migration and invasion. Gli1 over-expression increased the migration and invasion of MDA-MB-231 cells with a corresponding increase in expression of MMP-11. Silencing MMP-11 in MDA-MB-231 cells that over-expressed Gli1 abrogated the Gli1-induced enhancement of migration and invasion. Sustained suppression of Gli1 expression decreased growth of MDA-MB-231 in vitro by increasing apoptosis and decreasing proliferation. In addition, silencing of Gli1 reduced the numbers and sizes of pulmonary metastases of MDA-MB-231 in an in vivo experimental metastasis assay. In summary, Gli1 promotes the growth, survival, migration, invasion and metastasis of ERα negative breast cancer. Additionally, MMP-11 is up-regulated by Gli1 and mediates the migration and invasion induced by Gli1 in MDA-MB-231.
Synthese und Struktur des ersten homoleptischen Imidotechnetium‐Komplexes: [Tc<sub>2</sub>(NAr)<sub>6</sub>] (Ar = 2,6‐Diisopropylphenyl) (1993)

Eine ethanartige Struktur hat der Titelkomplex 1 , bei dem die sechs terminalen Imidoliganden gestaffelt bezüglich der Tc‐Tc‐Bindung angeordnet sind. Die bislang charakterisierten M 2 E 6 ‐Komplexe mit sterisch weniger anspruchsvollen, aber ebenfalls mehrfach gebundenen Liganden, lagen ausnahmslos als Dimere aus zwei kantenverknüpften Tetraedern vor. magnified image
Chromium(II) chemistry. Part 14. Ferromagnetic and antiferomagnetic tetrabromochromates(II) (1981)

The dihydrated chromium(II) complex bromides M2[CrBr4(OH2)2], where M = Cs, Rb, NH4, or Hpy (py = pyridine), are magnetically dilute, high-spin compounds. The ammonium salt is isomorphous with the analogous copper(II) bromide which is known to contain trans-[CuBr4(OH2)2]2– anions with two short and two long Cu–Br bonds. The piperazinium salts [H2pipz]2[CrBr6]·2H2O and [H2pipz]2[CrBr6], and the guanidinium salt [C(NH2)3]2[CrBr4]·2MeCO2H, are also magnetically dilute. Their reflectance spectra are as expected for tetragonally distorted octahedral anions. Thermal dehydration gives the compounds M2[CrBr4], where M = Cs, Rb, NH4′ NPhH3′ or Hpy, but the monoalkylammonium salts [NRH3]2[CrBr4], where R = Me, Et, Prn, Bun, n-C5H11,n-C8H17′, or n-C12H25′[NMe2H2]2[CrBr4], and [C(NH2)3]2[CrBr4]·2MeCo2H have been crystallised from glacial acetic acid, and [NEt4]2[CrBr4], from mixed organic solvents. Ferromagnetic behaviour is exhibited by Cs2[CrBr4] and the monoalkylammonium salts, but the other tetrabromochromates(II) are antiferromagnetic. The reflectance spectra indicate tetragonal six-co-ordination of CrII and hence polymeric structures. Like the analogous tetrachlorochromates(II), the magnetic data for the ferromagnetic tetrabromochromates from liquid-nitrogen to room temperature can be reproduced by the high-temperature series-expansion formula for a sheet ferromagnet with S= 2, and JBr > JCl. The reflectance spectra contain very sharp bands at ca. 15 600 and 18 400 cm–1 assigned to spin-forbidden transitions intensified by magnetic coupling. The magnetic behaviour of the antiferromagnetic complexes is reproduced by the high-temperature series-expansion formula with appropriate changes of sign. The stretching vibrations of the short Cr–Br bonds occur near 250 cm–1.
Phosphatidic Acid as the Biosynthetic Precursor of the Endocannabinoid 2‐Arachidonoylglycerol in Intact Mouse Neuroblastoma Cells Stimulated with Ionomycin (1999)

In mouse neuroblastoma N18TG2 cells prelabeled with [3H]arachidonic acid ([3H]AA) the biosynthesis of 2-arachidonoylglycerol (2-AG) is induced by ionomycin in a fashion sensitive to an inhibitor of diacylglycerol (DAG) lipase, RHC 80267, but not to four different phospholipase C (PLC) blockers. Pulse experiments with [3H]AA showed that ionomycin stimulation leads to the sequential formation of [3H]phosphatidic acid ([3H]PA), [3H]DAG, and [3H]2-AG. [3H]2-AG biosynthesis in N18TG2 cells prelabeled with [3H]AA was counteracted by propranolol and N-ethylmaleimide, two inhibitors of the Mg2+/Ca2(+)-dependent brain PA phosphohydrolase. Pretreatment of cells with exogenous phospholipase D (PLD) led to a strong potentiation of ionomycin-induced [3H]2-AG formation. These data indicate that DAG precursors for 2-AG in intact N18TG2 cells are obtained from the hydrolysis of PA and not through the activation of PLC. The presence of 2% ethanol during ionomycin stimulation failed to elicit the synthesis of [3H]phosphatidylethanol and did not counteract the formation of [3H]PA, thus arguing against the activation of PLD by the Ca2+ ionophore. Selective inhibitors of secretory phospholipase A2 and the acyl-CoA acylase inhibitor thimerosal significantly reduced [3H]2-AG biosynthesis. The implications of these latter findings, and of the PA-dependent pathways of 2-AG formation described here, are discussed.
Single fraction stereotactic radiosurgery (SRS) alone versus surgical resection and SRS boost for large brain metastases: A multi-institutional analysis. (2016)

2076 Background: SRS dose is typically limited by brain metastasis (BM) size. Any benefit for the addition of surgery to SRS for large BM in patients (pts) with oligometastatic brain disease is not well characterized. Methods: Large BM was defined as ≥ 4 cc (2 cm diameter) prior to the study. The records of consecutive pts treated with single fraction SRS alone or surgery with either pre-operative (pre-SRS) or post-operative SRS (post-SRS [collectively SRS boost]) between 2005 - 2013 from 2 institutions were reviewed. Pre-SRS dose was 20% reduced compared to standard SRS dosing, with planned resection within 48 hours. Overall survival (OS) analysis used the Kaplan-Meier method. Otherwise, cumulative incidence with competing risk was used. Results: Overall, 250 pts with 260 treated large BM were included, of which 66 were treated with SRS alone and 194 with surgery and SRS boost (65 pre-SRS, 129 post-SRS). Median imaging follow-up period was 29 months for alive pts. Groups were well balanced except for lesion volume (GTV, median 5.9 cc vs. 9.3 cc, p < 0.001), median number of BM (1.5 vs. 1, p = 0.006), and median SRS dose (18 vs. 15 Gy, p < 0.001), respectively. Local recurrence (LR) was significantly lower with SRS boost (1-year LR: 36.7% vs. 18.8%, p = 0.004), which remained significant in multivariate analysis (MVA, hazard ratio [HR]: 0.33, 95% confidence interval (CI): 0.17–0.62, p < 0.001). There was no difference in radiation necrosis (RN) by resection status, but post-SRS had significantly increased RN rate compared with pre-SRS or SRS alone (reference) in MVA (HR: 2.9, 95% CI: 1.04-8.5, p = 0.05, 1-year RN: 22%, 4.8%, 12.3%, p < 0.001, respectively). OS was significantly higher with SRS boost (2-year OS: 35.5% vs. 19.5%, p = 0.013), which remained significant in MVA (HR 0.57, 95% CI 0.36-0.89, p < 0.01). Conclusions: Surgical resection with SRS boost (either pre-SRS or post-SRS) is associated with significantly reduced LR and improved OS compared with SRS alone for large ( ≥ 4 cc) BM, despite larger average lesion size in the SRS boost group. Post-SRS was associated with the highest rate of RN. Surgical resection with SRS boost may improve outcomes in pts with a limited number of large BM.
Soil amendment with halophytes induces physiological changes and reduces root-knot infection in eggplant and okra (2011)

Root-knot nematode, Meloidogyne javanica (Treub) Chitwood is a soil-borne plant pathogen of roots. Nematode infection results in altered plant growth and physicochemical processes due to gall formation. Many plants contain unique biochemicals that have biocidal properties and offer a potential novel approach to suppress the nematode populations in soil and improve growth of crop plants. In the present study effect of some indigenous halophytic plant species (Tamarix indica Willd, Suaeda fruticosa Forssk and Salsola imbricata (Schultz) Dandy) were tested against M. javanica. Tested halophytes significantly (P<0.001) reduced egg hatching and caused mortality of second stage juveniles (J2) in vitro. These halophytes when incorporated in soil (0.3, 0.5 and 1% w/w) markedly increased growth of eggplant (Solanum melongena L. cv. Black beauty) and okra (Abelmoschus esculentus [L.] Moench. cv. Arka anamika) and provided control of root-knot infection at higher doses (0.5 and 1%). Amended eggplants and okra showed significant (P<0.001) increase in chlorophylls and decrease in chlorophyll a/b ratio. Protein concentration in leaves of both the plants were increased with 1% amendment of S. fruticosa and S. imbricata. While nucleic acid concentrations were varied with different treatments.
The Medusa of Spatial Sorting: Topological Construction (2012)

We consider the simultaneous movement of finitely many colored points in space, calling it a spatial sorting process. The name suggests a purpose that drives the collection to a configuration of increased or decreased order. Mapping such a process to a subset of space-time, we use persistent homology measurements of the time function to characterize the process topologically.
Back Modulation Type Flat CRT. (1994)

A back modulation-type flat CRT is developed.Using this device, it is possible to construct a large-area full-color flat CRT (30`50 inches in diagonal length for NTSC-TV and HDTV) .This paper describes the charge up influence from support vanes, a circuit that can be used in a color image driver, displayed color image, and how vertical resolution and brightness can be improved.To reduce the charge -up influence from support vanes , highly-resistant materials were used to coat the Al2O3 vanes.A multiplexing circuit for R E G EB signals was fabricated to display the color image, and we displayed the color image 1 inch in diagonal length.Vertical resolution and brightness were improved significantly by using a new vertical addressing method.This study confirms the effectiveness of using back modulation type flat CRTs in televisions.1.
Reduced gliotransmitter release from astrocytes mediates tau‐induced synaptic dysfunction in cultured hippocampal neurons (2017)

Tau is a microtubule-associated protein exerting several physiological functions in neurons. In Alzheimer's disease (AD) misfolded tau accumulates intraneuronally and leads to axonal degeneration. However, tau has also been found in the extracellular medium. Recent studies indicated that extracellular tau uploaded from neurons causes synaptic dysfunction and contributes to tau pathology propagation. Here we report novel evidence that extracellular tau oligomers are abundantly and rapidly accumulated in astrocytes where they disrupt intracellular Ca<sup>2+</sup> signaling and Ca<sup>2+</sup> -dependent release of gliotransmitters, especially ATP. Consequently, synaptic vesicle release, the expression of pre- and postsynaptic proteins, and mEPSC frequency and amplitude were reduced in neighboring neurons. Notably, we found that tau uploading from astrocytes required the amyloid precursor protein, APP. Collectively, our findings suggests that astrocytes play a critical role in the synaptotoxic effects of tau via reduced gliotransmitter availability, and that astrocytes are major determinants of tau pathology in AD.