gebhart/patrepeval huggingface dataset:
Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland (2005)

The mammary gland, like most tissues, produces measurable amounts of prostaglandin E 2 (PGE 2 ), a metabolite of arachidonic acid produced by sequential actions of two cyclooxygenases (COX-1 and COX-2) and three terminal PGE synthases: microsomal prostaglandin E 2 synthase-1 (mPGES1), mPGES2, and cytosolic prostaglandin E 2 synthase (cPGES). High PGE 2 levels and COX-2 overexpression are frequently detected in mammary tumors and cell lines. However, less is known about PGE 2 metabolic enzymes in the context of normal mammary development. Additionally, the primary COX partnerships of terminal PGE synthases and their contribution to normal mammary PGE 2 biosynthesis are poorly understood. We demonstrate that expression of COX-1, generally considered constitutive, increases dramatically with lactogenic differentiation of the murine mammary gland. Concordantly, total PGE 2 levels increase throughout mammary development, with highest levels measured in lactating tissue and breast milk. In contrast, COX-2 expression is extremely low, with only a modest increase detected during mammary involution. Expression of the G s -coupled PGE 2 receptors, EP2 and EP4, is also temporally regulated, with highest levels detected at stages of maximal proliferation. PGE 2 production is dependent on COX-1, as PGE 2 levels are nearly undetectable in COX-1 -deficient mammary glands. Interestingly, PGE 2 levels are similarly reduced in lactating glands of mPGES1 -deficient mice, indicating that PGE 2 biosynthesis results from the coordinated activity of COX-1 and mPGES1. We thus provide evidence for the first time of functional coupling between COX-1 and mPGES1 in the murine mammary gland in vivo. -
Semiconductor optical amplifier switch matrices for optical header recognition (2008)

All-optical header recognition using a tree-structure is reported for a three-bit address. Each bit of a three bit header is read using an optical Sagnac AND gate and the outcome is used to control each level of the three level tree-structure switch. Traffic at 10 Gb/s (payload) is directed through the switch and each possible address outcome is validated. Reflective semiconductor optical amplifiers (RSOAs) are used as the 1 x 2 space switch at each node of the tree-structure switch. A noise propagation analysis that considers mostly amplified spontaneous emission noise is presented. This analysis takes into account the saturation power of the SOAs, their noise figure, the gain of each SOA and the coupled optical power. It is concluded that large switches based on semiconductor optical amplifiers can be constructed using cascaded SOAs.
Detections of Commercial Fluorosurfactants in Hong Kong Marine Environment and Human Blood: A Pilot Study (2013)

Previously, much of the perfluoroalkyl and polyfluoroalkyl substance (PFAS) research has focused on perfluoroalkyl carboxylates (PFCAs) or perfluoroalkane sulfonates (PFSAs). Recent studies indicate that known PFCAs and PFSAs accounted for 5-95% of the organofluorine (OF) in human and wild rat blood samples suggesting that a relatively large proportion of OF remained unknown. Until recently, some studies reported commercially available compounds such as polyfluoroalkyl phosphate diesters (diPAPs) and fluorotelomer sulfonates (FTSAs) in human blood and sludge samples. The present investigation is a pilot study aiming at surveying some newly identified PFASs such as diPAPs, FTSAs, and perfluorinated phosphinates (PFPiAs) in different environmental samples including surface water, sediment, sewage treatment plant influent and effluent, sludge, benthic worm, and human blood from Hong Kong. DiPAPs (6:2, 6:2/8:2, and 8:2) were detected in some of the samples at part-per-billion (ppb) levels in sludge, sub ppb levels in influent and effluent, sediment, worm, and human blood samples, and sub part-per-trillion (ppt) levels in surface waters. Sub ppt to ppb levels of 6:2 and 8:2 FTSAs were observed in worm, surface water, and human blood samples. PFPiAs were only observed in worm samples. The detected "new PFASs" accounted for a minor proportion (less than 5%) of the total PFASs in benthic worm and human blood, but up to 95% in sewage sludge samples from Hong Kong. This is the first report of commercial fluorosurfactants (PFPiAs, diPAPs, and FTSAs) in the samples from the environment and human blood in Hong Kong; further information on the distribution, fate, and transport of "new PFASs" in other Asian cities, as well as toxicity, is needed for further assessing the human exposure and risk.
Acid Hydrolysis of Mono-hydroxyethyl Ethers of Methyl alpha- and beta-D-Glucopyranoside. (1968)

Abstract : The eight mono-hydroxyethyl ethers of method alpha- and beta-D-glucopyranoside have been prepared and their acid hydrolysis investigated. They were all hydrolysed at a lower rate than the unsubstituted glucosides. The results are discussed in relation to similar studies of other ethers of these glucosides and to the acid hydrolysis of polysaccharides. (Author)
Titanium nitride films (2017)

Hot carrier cooling rates were measured using transmission pump-probe on 30nm TiN films. Experiments used a 400nm pump/800nm probe and a 650nm pump/800nm probe. The bandstructure gives insight into the long cooling times observed.
Threshold of Audibility as a Function of Tone Duration: Is There a Frequency Effect? (1970)

The threshold of audibility of pure tones was measured by means of six psychophysical methods: adjustment, limits, constant stimuli, Békésy tracking, forced-choice tracking, and confidence rating. The measurements were made at 250, 1000, and 4000 Hz for stimulus durations of 10, 25, 50, 100, 200, and 500 msec. The results obtained with the methods of adjustment, limits, constant stimuli, and confidence rating show a clear frequency dependence of the threshold shift as a function of stimulus duration—the threshold shift decreases as sound frequency increases. The results of the tracking methods do not show such an effect. An analysis of variance performed for the 10-msec duration indicates a frequency effect at the 5% level of significance and an even more significant method-frequency interaction. This outcome should resolve to some extent the issue of the frequency dependence of threshold-duration characteristics.
Wideband TLM modeling of microwave structures with anisotropic and dispersive media (2010)

International audience
Effect of galanin on substance P- and vasoactive intestinal polypeptide-induced nociceptive trigemino-hypoglossal reflex in rats. (2007)

Substance P (SP), vasoactive intestinal polypeptide (VIP) and galanin (GAL), present in primary sensory neurons, are involved in transmission of nociceptive signaling from the peripheral to central nervous system. In this study we investigated the effect of GAL on SP-induced or VIP-induced evoked tongue jerks (ETJ) in response to noxious tooth pulp stimulation during perfusion of the cerebral ventricles with SP or VIP solutions. The experiments were carried out on rats under chloralose anesthesia. It was shown that both, SP and VIP, perfused through the cerebral ventricles enhanced the ETJ amplitude as compared with control, but the effect produced by SP was stronger. The intracerebroventricular perfusion of GAL 5 minutes before SP caused a dose-dependent inhibition of SP-induced ETJ, whereas GAL perfused through the cerebral ventricles 5 minutes before VIP did not reduce the excitatory effect of VIP on ETJ. These results indicate that the antinociceptive effect of GAL perfused through the cerebral ventricles, tested on the trigemino-hypoglossal reflex in rats, is specifically mediated by the SP-ergic system.
Separation of Hydrogen by Natural Zeolite. (1991)

Permeation of hydrogen through natural zeolite was studied to obtain the fundamental data for the separation of hydrogen. The following results are obtained.The membrane made of natural zeolite, which is yieled from Itaya of Yonezawa city of Yamagata prefecture, has the excellent heat-resistance and the complicated porous structure like a maze. The pore sizes of the membrane are found to be distributed from 80 to 10, 000 Å. It is also found that Itaya natural zeolite has many suitable pore sizes from 80 to 300 Å for the separation of hydrogen by Knudsen flow.The rate of gas permeation increased as the operational pressure difference increased. The separation factor of hydrogen is affected by the ratio of the pressure of permeated gas P2 to the pressure of feed gas P1, and increases with an increase in the pressure difference. The pressure reduction of permeated gas was found to be very effective to increase the hydrogen separation factor of the membrane. It was also found that the rate of gas permeation was reduced in some degree as the operational temperature increased up to 523K, but that the separation of hydrogen by the membrane was improved.These experimental results mentioned above reveal that Itaya natural zeolite can be utilized for the hydrogen separation from gas mixture under the wide range of opertional conditions of temperature and pressure.
Control de histéresis de la corriente del condensador de salida de un reductor operando a frecuencia constante (2009)

La combinacion del control no-lineal y lineal propuesto en [1] presenta una muy rapida respuesta dinamica (escalones de tension de 1 V a 1,5 V en 2 μs). Este control se basa en el control de histeresis de la corriente del condensador de salida (Cout ). Sin embargo, el sistema es muy sensible a diferentes efectos parasitos que modifican la frecuencia de conmutacion tales como: variacion de la tension de entrada, tension de salida, etc. En este articulo se propone un lazo de frecuencia adicional para corregir las variaciones de frecuencia y ajustar la frecuencia de conmutacion al valor nominal mediante el ajuste de la banda de histeresis. El diseno y analisis del lazo no-lineal, lineal y el lazo de frecuencia son presentados en detalle este articulo. Para la validacion experimental se ha construido un convertidor reductor a 5 MHz. La respuesta dinamica del convertidor ante escalones de tension en la referencia (escalones de 1,5 V a 2,5 V y de 2,5 V a 1,5 V) es rapida y mantiene constante la frecuencia de conmutacion en estado estacionario.
66% CW wallplug efficiency from Al-free 0.98 µm-emittingdiode lasers (1996)

0.98 µm-emitting, broad-waveguide-type InGaAs/InGaP/GaAs diode lasers have been optimised for maximum wallplug efficiency. Optimised-facet-coated, 100 µm-widestripe, 500 µm-long devices having InGaAsP optical-waveguide thicknesses of 0.6 and 1.2 µm provide maximum wallplug efficiencies of 66% and 62%, respectively. Carbon-doped cap layers allow for a series resistance of 0.08 Ω for devices with 100 × 500 µm2 contact area.
Introducing path computation element (PCE) in optical grid networking (2008)

A PCE-based scheme is proposed to enhance grid resource selection with network information. The amount of established grid services is increased without significantly affecting the service set up time.
LC-MS/MS method for hepcidin-25 measurement in human and mouse serum: clinical and research implications in iron disorders (2015)

Therefore, we propose this adaptive LC-MS/MS method as a suitable method for accurate determination of hepcidin-25 in clinical samples and as a major tool contributing to the clinical diagnosis, follow-up and management of iron-related disorders. It also opens new avenues to measure hepcidin in animal models without interspecies antigenic limitations.
A subgroup analysis to evaluate the efficacy and safety of adapalene-benzoyl peroxide topical gel in black subjects with moderate acne. (2014)

Three multicenter, randomized, double blind, parallel-group, placebo controlled studies involving 3,855 subjects established the safety and efficacy of an adapalene benzoyl peroxide topical gel in the treatment of acne for all skin types. The data from these 3 studies were pooled and the subgroup of self-identified black subjects was analyzed separately. Significantly more black subjects had IGA success with adapalene-BPO than with vehicle at week 12. Significantly more black subjects also had decreased total, inflammatory, and noninflammatory lesion counts with adapalene-BPO that were seen as early as week 1. Adapalene-BPO was well tolerated in the black subjects included in this analysis and no cases of treatment-related PIH were observed. Similar results were obtained for this subgroup as the overall population from the 3 studies. Based on the results from this analysis, adapalene-BPO is a safe and effective treatment for acne in black skin.
Women's Health and Human Rights in Afghanistan (1998)

The current health and human rights status of women described in this report suggests that the combined effects of war-related trauma and human rights abuses by Taliban officials have had a profound effect on Afghan women's health. Moreover, support for women's human rights by Afghan women suggests that Taliban policies regarding women are incommensurate with the interests, needs, and health of Afghan women.
Meßmikroskop und Profilprojektor (2002)

Kennzeichnend für Meßmikroskope und Profilprojektoren ist die optische "Antastung" des Meßobjektes. Der Prüfer visiert mit einer Marke im Okularbild oder auf dem Bildschirm das vergrößerte Bild des Meßobjektes an. Die Vergrößerungen liegen im Bereich 5... 100-fach.
Complementary oxide memristor technology facilitating both inhibitory and excitatory synapses for potential neuromorphic computing applications (2009)

A new family of crystalline oxides is identified that provide a method of producing complementary memristance (both n and p-type having been demonstrated) with unusually large demonstrated memristance behavior. To the best of our knowledge, these are the only devices having a large enough memristance to have measureable memristance at the macroscopic (10's to 100's of um device size) scale. Additionally, the oxides are highly conducting (low loss) with resistivities for both n and p-type variants in the -5E-4 ohm-cm range. Complementary oxide memristors (both n-type and p-type) have been demonstrated in the same material contrasting all other known memristor technologies which are unipolar. Such behavior could be useful in future neuromorphic computing since n-type material exhibits inhibitory synaptic response (increasing resistance with time/voltage) while p-type material exhibits excitatory synaptic response (decreasing resistance with time/voltage). In principle (not yet demonstrated) this core complementary technology can fully implement neuron/synapse brain function without the need for traditional CMOS.
Bond of reinforcing bars in self-compacting steel fiber reinforced concrete (2002)

Plain concrete demonstrates a rather brittle behavior both under compression and tension. By adding steel fibers, the post-cracking behavior becomes more ductile and an increase of the strain capacity under tension and compression is found. The research project currently being carried out aims at the development of a model that describes the local bond behavior of deformed bars embedded in a steel fiber reinforced matrix. Considering contradictory conclusions from earlier investigations found in the literature a systematic experimental investigation was carried out. Pull-out tests were carried out on 10 mm diameter deformed reinforcing bars embedded along three times the bar diameter in 200 mm cubes. Plain and steel fiber reinforced concrete (SFRC) with normal strength (B45) were used. The content of fibers was 60 and 120 kg/m3, respectively. While the fiber length was constant (30 mm), the fiber aspect ratio (length/diameter) was varied (45 and 80). Four different concrete covers (15, 25, 35, and 95 mm) were used to investigate both bond failure by splitting of the concrete cover and by shearing off of the concrete corbels between the ribs on the bars. The force-end slip relation was measured and the local bond behavior was analyzed. For a concrete cover of 15 mm, the addition of steel fibers was found to prevent the occurrence of visible splitting cracks, leading to higher bond ductility. The concrete cover thickness of SFRC was found to influence the bond behavior in a similar way as it does for plain concrete.
Engineering of hypoallergenic mutants of the <i>Brassica</i> pollen allergen, Bra r 1, for immunotherapy (1998)

The Brassica pollen allergen Bra r 1 belongs to a new family of Ca2+-binding proteins, characterized by the presence of two potential EF-hand calcium-binding domains. Disruption of these EF-hand motifs by amino acid substitutions demonstrated that both domains of Bra r 1 constitute functional Ca2+-binding sites. Calcium-binding deficient mutants displayed significantly reduced IgE-binding activity. Injection of these mutated Bra r 1 variants into a murine model system showed that mouse IgG raised against the mutants recognized native Bra r 1 in Brassica pollen extracts suggesting the potential use of the engineered allergens for effective immunotherapy.
Identification of 10-Hydroxy-12<i>Z</i>-octadecenoic and 10-Hydroxy-12<i>Z</i>, 15<i>Z</i>-octadecadienoic Acids in Corn Silage (1986)

Journal Article Identification of 10-Hydroxy-12Z-octadecenoic and 10-Hydroxy-12Z, 15Z-octadecadienoic Acids in Corn Silage Get access Kazuhiko Sakata, Kazuhiko Sakata Laboratory of Chemistry, The College of Dairying, Bunkyodai-midorimachi, Ebetsu, Hokkaido 069, Japan Search for other works by this author on: Oxford Academic Google Scholar Naoya Takizawa, Naoya Takizawa Laboratory of Chemistry, The College of Dairying, Bunkyodai-midorimachi, Ebetsu, Hokkaido 069, Japan Search for other works by this author on: Oxford Academic Google Scholar Ushio Sankawa, Ushio Sankawa Faculty of Pharmaceutical Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Yutaka Ebizuka, Yutaka Ebizuka Faculty of Pharmaceutical Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Noguchi Hiroshi Noguchi Faculty of Pharmaceutical Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 50, Issue 4, 1 April 1986, Pages 1077–1079, https://doi.org/10.1080/00021369.1986.10867523 Published: 01 April 1986 Article history Received: 07 November 1985 Published: 01 April 1986
ISA extensions for high-radix online floating-point addition (2007)

ISA extensions for DLX type architectures are proposed to perform high radix online floating point addition on fixed point units with extended feature sets. Online arithmetic allows most significant digit first computation of results, allowing overlapped execution of dependent operations and offers greater instruction scheduling opportunities than software implementations of conventional floating point addition. In this paper we seek an ISA formulation to find a middle ground between full hardware floating point addition units and software implementations strictly based on available ALU logic.
The vasodilatory peptide maxadilan increases vascular permeability due to activation of leukocytes in postcapillary venules (2010)

The vasodilatory peptide maxadilan (MAX) isolated from the sand fly Lutzomyia longipalpis induces plasma leakage in postcapillary venules of the hamster cheek pouch (HCP) via PAC‐1‐receptor stimulation. Here we studied arteriolar dilation, plasma leakage (FITC‐dextran 150) and accumulation of rhodamine‐labeled leukocytes in the HCP induced by topical applications of MAX 134 nM alone or combined with 8 μM M‐65, a PAC1‐receptor antagonist. Arteriolar diameter, plasma leakage (FITC‐fluorescence) and leukocyte accumulation (rhodamine‐fluorescence) was measured in digital camera images with a computer software (AxioVision 4.4). Four groups of hamsters, saline control, MAX 134 nM, MAX + M‐65 and FITC‐dextran 40 + MAX were studied. Applications of MAX and M‐65 were made topically to the HCPs in 250 μl of saline and images were recorded for 60 minutes. There was no plasma leakage increase in the saline control group but a slight increase in leukocyte accumulation. In contrast there was a lasting increase in plasma leakage (180%, P < 0.05) and leukocyte accumulation (150%, P < 0.05) in the MAX‐group with peak responses at 40 min and 60 min, respectively, that was inhibited by M‐65 and FITC‐dextran 40. M‐65 also inhibited arteriolar dilation while there was no significant inhibition of dilation in the FITC‐dextran 40 group. Conclusion: PAC1‐receptor activation by maxadilan causes plasma leakage and leukocyte accumulation independent of its vasodilatory effect.
FoveAR (2015)

Optically see-through (OST) augmented reality glasses can overlay spatially-registered computer-generated content onto the real world. However, current optical designs and weight considerations limit their diagonal field of view to less than 40 degrees, making it difficult to create a sense of immersion or give the viewer an overview of the augmented reality space. We combine OST glasses with a projection-based spatial augmented reality display to achieve a novel display hybrid, called FoveAR, capable of greater than 100 degrees field of view, view dependent graphics, extended brightness and color, as well as interesting combinations of public and personal data display. We contribute details of our prototype implementation and an analysis of the interactive design space that our system enables. We also contribute four prototype experiences showcasing the capabilities of FoveAR as well as preliminary user feedback providing insights for enhancing future FoveAR experiences.
Diversity of New Structural Types in Polynuclear Iron Chemistry with a Tridentate N,N,O Ligand (2007)

The syntheses, crystal structures, and magnetochemical characterization of four new iron clusters [Fe7O4(O2CPh)11(dmem)2] (1), [Fe7O4(O2CMe)11(dmem)2] (2), [Fe6O2(OH)4(O2CBut)8(dmem)2] (3), and [Fe3O(O2CBut)2(N3)3(dmem)2] (4) (dmemH=Me2NCH2CH2N(Me)CH2CH2OH)=2-{[2-(dimethylamino)ethyl]methylamino}ethanol) are reported. The reaction of dmemH with [Fe3O(O2CR)6(H2O)3](NO3) (R=Ph (1), Me (2), and But (3)) gave 1, 2, and 3, respectively, whereas 4 was obtained from the reaction of 3 with sodium azide. The complexes all possess rare or novel core topologies. The core of 1 comprises two [Fe4(mu3-O)2]8+ butterfly units sharing a common body Fe atom. The core of 2 consists of a [Fe3O3] ring with each doubly bridging O2- ion becoming mu3 by also bridging to a third, external Fe atom; a seventh Fe atom is attached on the outside of this core via an additional mu3-O2- ion. The core of 3 consists of a [Fe4(mu3-O)2]8+ butterfly unit with an Fe atom attached above and below this by bridging O atoms. Finally, the core of 4 is an isosceles triangle bridged by a mu3-O2- ion with a rare T-shaped geometry and with the azide groups all bound terminally. Variable-temperature, solid-state dc, and ac magnetization studies were carried out on complexes 1-4 in the 5.0-300 K range. Fitting of the obtained magnetization (M) vs field (H) and temperature (T) data by matrix diagonalization and including only axial anisotropy (zero-field splitting) established that 1, 2, and 4 each possess an S=5/2 ground state spin, whereas 3 has an S=5 ground state. As is usually the case, good fits of the magnetization data could be obtained with both positive and negative D values. To obtain more accurate values and to determine the sign of D, high-frequency EPR studies were carried out on single crystals of representative complexes 1.4MeCN and 3.2MeCN, and these gave D=+0.62 cm-1 and |E|>or=0.067 cm-1 for 1.4MeCN and D=-0.25 cm-1 for 3.2MeCN. The magnetic susceptibility data for 4 were fit to the theoretical chiM vs T expression derived by the use of an isotropic Heisenberg spin Hamiltonian and the Van Vleck equation, and this revealed the pairwise exchange parameters to be antiferromagnetic with values of Ja=-3.6 cm-1 and Jb=-45.9 cm-1. The combined results demonstrate the ligating flexibility of dmem and its usefulness in the synthesis of a variety of Fex molecular species.