gebhart/patrepeval huggingface dataset:
Use of a Centrifuge-Based Automated Blood Cell Counter for Radiation Dose Assessment (2006)

Hematological changes create early-response biomarkers for assessing radiation doses. Existing dose-prediction models are based on serial blood lymphocyte counts after acute whole-body exposure to gamma-radiation. Measurements of lymphocyte-depletion kinetics after possible exposures are useful for triaging patients and managing medical resources. The small-footprint QBC Autoread Plus System provides cost-effective hematological analyses with reproducibility, accuracy, and a broad dynamic range. QBC analysis measures centrifugally packed, whole blood cells in microhematocrit tubes and reports pooled lymphocyte and monocyte counts. Our objective was to modify this procedure to report pure lymphocyte counts for radiation biodosimetry applications. The CD14 antigen is strongly expressed on most human monocytes. Using anti-CD14-coated Dynabeads, we have devised a rapid method for depleting monocytes from whole blood without altering the lymphocyte viability or count. This simple dry procedure provides reliable lymphocyte counts for results that fall within the normal lymphocyte count range (1-4 x 10(9) cells per L) for radiation exposure assessment using lymphocyte-depletion kinetics.
Le décor biblique d'une maison de la Renaissance à Rouen (1958)

Beaulieu Michèle. Le décor biblique d'une maison de la Renaissance à Rouen. In: Bulletin Monumental, tome 116, n°2, année 1958. pp. 148-149.
Properties of high density polyethylene and its behaviour under ‘Galisol’ heat storage conditions (1990)

High density polyethylene (HDPE), crosslinked by electron beams in air, is presented as a latent heat storage material for energy storage applications at a temperature level of about 120°C. The study includes thermal investigations before and after the irradiation, investigations of the form stability, gel content determinations and microscopic investigations of HDPE. An electron energy of 0.4 MeV and a radiation dosage of 200 kGy were found to be the optimum conditions for the irradiation of the investigated HDPE in air. The pellets obtained were form-stable owing to the formation of a thin crosslinked surface layer (about 0.5 mm thickness). In spite of the presence of oxygen during irradiation, the melting enthalpy of the initial state was retained almost quantitatively. Apart from that, a quasicomplete irradiation of the pellets in volume in air, with a higher electron energy, is also possible. In this case about 95% of the initial melting enthalpy is obtained, providing a maximum gel content of 50%. Moreover, the paper offers a possibility of overcoming the low heat transfer power of HDPE by applying it in form of modified pellets in a ‘Galisol’ model storage unit with water as the heat transfer liquid. Owing to the large heat transfer area connected to boiling and condensation of water, excellent values of heat transfer power of 100–114 W/kg HDPE (ΔT=16 K) are obtained. These are comparable to those of salt hydrates, provided there is sufficient form stability. The significant influence of somewhat lower form stability on the heat output is shown.
A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells. (1999)

Adherence of leukocytes to cells undergoing apoptosis has been reported to be dependent on a variety of recognition pathways. These include alpha V beta 3 (CD51/CD61, vitronectin receptor), CD36 (thrombospondin receptor), macrophage class A scavenger receptor, phosphatidylserine translocated to the outer leaflet of apoptotic cell membranes, and CD14 (LPS-binding protein). We investigated the mechanism by which leukocytes adhere to apoptotic endothelial cells (EC). Peripheral blood mononuclear leukocytes and U937 monocytic cells adhered to human or bovine aortic EC induced to undergo apoptosis by withdrawal of growth factors, treatment with the promiscuous protein kinase inhibitor staurosporine, with the protein synthesis inhibitor and protein kinase activator anisomycin, or with the combination of cycloheximide and TNF-alpha. Expression of endothelial adherence molecules such as CD62E (E-selectin), CD54 (ICAM-1), and CD106 (VCAM-1) was not induced or increased by these treatments. A mAb to alpha V beta 3, exogenous thrombospondin, or blockade of phosphatidylserine by annexin V did not inhibit leukocyte adherence. Further, leukocyte binding to apoptotic EC was completely blocked by treatment of leukocytes but not EC with mAb to beta 1 integrin. These results define a novel pathway for the recognition of apoptotic cells.
Corrosion, a major failure mechanism in offshore wind : how to predict, detect and manage (bio-)corrosion? (2009)

References Corrosion is a top three failure mechanism for offshore wind farms. The mechanisms that must be taken into account include degradation of organic coatings and local corrosion mechanisms like Microbiologically Influenced Corrosion (MIC). Zones affected by corrosion include the coated tower, transition piece and internal/external surface of the mono pile. MIC plays a larger role in enclosed and inaccessible areas.
Outcome and serum ion determination up to 11 years after implantation of a cemented metal-on-metal hip prosthesis (2009)

Revisions for aseptic loosening and radiographic findings in the sockets led us to halt metal-on-metal-backed polyethylene cemented hip arthroplasty procedures. If the rigidity of the cemented socket is a reason for loosening, excessive release of metal ions and particles may be involved. Further investigations are required to confirm this hypothesis and to determine whether subluxation, microseparation, and hypersensitivity also play a role.
Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes (2002)

On the human long-arm pseudoautosomal region (XqPAR), genes that are subject to inactivation are closely linked with those that escape. Genes subject to inactivation are not only silenced on the inactive X in females, but they are also inactivated on the Y chromosome in males. One of the genes subject to this unusual inactivation pattern is the synaptobrevin-like 1 gene (SYBL1). Previously we showed that its silencing on the inactive X and the Y allele involves DNA methylation. This study explores the molecular events associated with SYBL1 silencing and investigates their relationship. Promoter DNA methylation profiles were determined by bisulfite sequencing and immunoprecipitation experiments demonstrate that chromatin on the repressed Xi and the Y alleles has underacetylated histones H3 and H4 and H3-lysine 9 methylation. In addition, the inactive X and the Y allele were found to have a condensed chromatin conformation. In contrast, the expressed allele shows H3 and H4 acetylation, H3-lysine 4 methylation and a less compacted chromatin conformation. In ICF syndrome, a human disease affecting DNA methylation, SYBL1 escapes from silencing and this correlates with altered patterns of histone methylation and acetylation. Combined, our data suggest that specific combinations of histone methylation and acetylation are involved in the somatic maintenance of permissive and repressed chromatin states at SYBL1. Although it is unclear at present how this allele-specific silencing comes about, the data also indicate that the epigenetic features of the 'Y inactivation' of SYBL1 are mechanistically similar to those associated with X-chromosome inactivation.
The subjective reliability of a newly recruited visual cue is similar whether or not a long-trusted cue is also present in the stimulus (2010)

The adult human visual system robustly recruits stimulus position (i.e. visual direction) as a cue for disambiguating the apparent rotation directions of 3D figures, as the result of training during which position is paired with binocular disparity and occlusion (Haijiang, Saunders, Stone & Backus, 2006). How should we measure the system's reliance on the newly recruited cue? Backus & Haijiang (2007) used conflict stimuli to quantify reliance in units of disparity, but one can also measure reliance in units of decision noise using probit analysis (Dosher, Sperling & Wurst, 1986). We hypothesized that reliance on the new cue would generalize completely from binocular to monocular viewing. Each of six trainees viewed 480 training stimuli and 480 test stimuli in alternation. 2/3 of the test stimuli contained small binocular disparities that agreed or conflicted with the new position cue. The remaining test stimuli were monocular. The the new cue was differently effective across trainees, from 0.6 to 5.8 normal equivalent deviations (NEDs), but had similar effects for monocular and binocular stimuli within each trainee. Across trainees, mean difference ± SE was 0.1±0.4 NED, with r = 0.89 (p [[lt]]0.02). The results are consistent with a model in which the visual system chooses one or the other perceptual interpretation according to subjective reliabilities, determined by the cues, that act like Bayes factors. Additivity of effects is predicted by identifying the cues either with log likelihoods or with “equivalent Bernoulli experiments” to estimate a posterior Bernoulli probability. Explaining perceptual bistability differs from explaining rivalry because one can ignore the time course of decision making. Unlike rivalry, binary perceptual decisions can easily be treated within existing theoretical frameworks for cue combination, which makes bistable stimuli highly appropriate for testing quantitative models of cue recruitment and cue combination.
Modeling and Evaluation of Miles-in-Trail Restrictions in the National Air Space (2003)

Miles-in-trail restrictions impact flights in the national air space on a daily basis and these restrictions routinely propagate between adjacent Air Route Traffic Control Centers. Since overly restrictive or ineffective miles-in-trail restrictions can reduce the overall efficiency of the national air space, decision support capabilities that model miles-in-trail restrictions should prove to be very beneficial. This paper presents both an analytical formulation and a linear programming approach for modeling the effects of miles-in-trail restrictions. A methodology for monitoring the conformance of an existing miles-in-trail restriction is also presented. These capabilities have been implemented in the Future ATM Concepts Evaluation Tool for testing purposes. To allow alternative restrictions to be evaluated in post-operations, a new mode of operation, which is referred to as the hybrid-playback mode, has been implemented in the simulation environment. To demonstrate the capabilities of these new algorithms, the miles-in-trail restrictions, which were in effect on June 27, 2002 in the New York Terminal Radar Approach Control, are examined. Results from the miles-in-trail conformance monitoring functionality are presented for the ELIOT, PARKE and WHITE departure fixes. In addition, the miles-in-trail algorithms are used to assess the impact of alternative restrictions at the PARKE departure fix.
DWDM Transmission of 128Gb/s PM-16QAM Signal over 1815km of 7-core MCF Using Shared Carrier Reception for Improving the Received Signal Quality (2013)

We demonstrate SCR method with 1815km transmission of 128Gb/s PM-16QAM over 7-core MCF using ECL. Frequency offset compensation of SCR enables demodulation and tolerates more than 10% path difference. Phase noise compensation of SCR enables to extend the transmitted distance, when using DFB, up to 1650km provided precise skew adjustment.
The metabolism and function of urocanic acid in skin. (1967)

Protection against actinic damage constitutes one of the important functions of the epidermis. Among the epidermal constituents which absorb the energy of light are keratin, melanoprotein in the form of melanin granules, nucleic acids, lipids, carotenes and porphyrins (1). Until recently, melanin and the stratum corneum have been the focus of study as photoprotective agents. With the demonstration that the surface of the skin and the epidermis contain large amounts of a water soluble, ultraviolet-absorbing material, interest developed in identifying this compound and elucidating its role in the vital functions of the skin (2).
The need for rules of engagement applied to wireless body area networks (2006)

Wireless body area networks (WBANs) and their supporting information infrastructures offer unprecedented opportunities to monitor state of health without constraining wearer activities. To increase acceptance of personal monitoring technology while lowering equipment cost, advances must be made in portability, power efficiency, security, and system- and device-level interoperability. This paper addresses the needs of future point-of-care environments that will employ adhoc WBANs for patient monitoring and treatment, emphasizing the need for strict rules of engagement that govern ad-hoc interactions, device associations, and security protocols. It then summarizes the use cases and constraints that will help to formulate rules of engagement for smart, interoperable components that operate within a distributed medical monitoring environment populated by WBANs and other local sensors.
and haplotypes in dogs (2002)

The DLA class II genes in the dog major histocompatibility complex are highly polymorphic. To date, 52 DLA-DRB1, 16 DLA-DQA1 and 41 DLA-DQB1 allelic sequences have been assigned. The aim of this study was to examine the intrabreed and interbreed variation of DLA allele and haplotype frequencies in dogs, and to ascertain whether conserved DLA class II haplotypes occur within and between different breeds. One thousand and 25 DNA samples from over 80 different breeds were DLA class II genotyped, the number of dogs per breed ranging from 1 to 61. DNA sequence based typing and sequence specific oligonucleotide probing were used to characterize dogs for their DLA-DRB1, DQA1 and DQB1 alleles. The high frequency of DLA class II homozygous animals (35%), allowed the assignment of many haplotypes despite the absence of family data. Four new DLA alleles were identified during the course of this study. Analysis of the data revealed considerable interbreed variation, not only in allele frequency, but also in the numbers of alleles found per breed. There was also considerable variation in the number of breeds in which particular alleles were found. These interbreed variations were found in all three DLA class II loci tested, and also applied to the three-locus haplotypes identified. Within this data set, 58 different DLA- DRB1/DQA1/DQB1 three-locus haplotypes were identified, which were all found in at least two different animals. Some of the haplotypes appeared to be characteristic of certain breeds. The high interbreed, and relatively low intrabreed, variation of MHC alleles and haplotypes found in this study could provide an explanation for reports ofinterbreed variation of immune responses to vaccines, viruses and other infections. 1 , 1 ,
Circulating soluble immune complexes containing pseudomonas antigens in cystic fibrosis. (1982)

In order to investigate whether circulating immune complexes containing Pseudomonas aeruginosa antigens mediate pulmonary damage in cystic fibrosis, we studied lung function, serum immune complex levels, and immunoglobulin concentrations in relationship to chronic pseudomonas colonisation in 69 affected children. Sixteen of the children with cystic fibrosis had increased levels of immune complexes which contained pseudomonas antigens. There was no significant relationship between lung function corrected for the effect of chronic pseudomonas colonisation and the presence of such complexes or increased levels of complexes detected by Cl1 binding or raised serum immunoglobulin concentrations. Our results suggest that these abnormalities in cystic fibrosis are secondary effects of chronic infection and they do not provide evidence for immune complex mediated lung damage in this disease.
High finesse external cavity VCSELs: from very low noise lasers to dual frequency lasers (2010)

Low noise-level optical sources are required for numerous applications such as microwave photonics, fiber-optic sensing and time/frequency references distribution. In this paper, we demonstrate how inserting a SC active medium into a centimetric high-Q external cavity is a simple way to obtain a shot-noise-limited laser source over a very wide frequency bandwidth. This approach ensures, with a compact design, a sufficiently long photon lifetime to reach the oscillation-relaxation- free class-A regime. This concept has been illustrated by inserting a 1/2-VCSEL in an external cavity including an etalon filter. A -156dB/Hz relative intensity noise level is obtained over the 100 MHz to 18 GHz bandwidth of interest. This is several orders of magnitude better than the noise, previously observed in VCSELs, belonging to the class-B regime. The optimization, in terms of noise, is shown to be a trade-off between the cavity length and the laser mode filtering. The transition between the class-B and class-A dynamical behaviors is directly observed by continuously controlling the photon lifetime is a sub-millimetric to a centimetric cavity length. It's proven that the transition occurs progressively, without any discontinuity. Based on the same laser architecture, tunable dual-frequency oscillation is demonstrated by reducing the polarized eigenstates overlap in the gain medium. The class-A dynamics of such a laser, free of relaxation oscillations, enables to suppress the electrical phase noise in excess, usually observed in the vicinity of the beat note. An original technique for jitter reduction in mode-locked VECSELs is also investigated. Such lasers are needed for photonic analog to digital converters.
Intramolecular cyclization of 4‐aryl‐1,4‐dihydropyridine acetals (1987)

Abstract The synthesis of 4‐aryl‐1,4‐dihydropyridines possessing a protected aldehyde functionality at the ortho position is described. These compounds undergo iminium ion mediated cyclization when treated with titanium tetrachloride or gaseous hydrogen chloride. Mechanistically, cyclization utilizes attack of C‐3 of the dihydropyridine on the electrophilic species generated from complexation of the acetal. This methodology highlights opportunities for the construction of novel conformationally constrained dihydropyridine analogs.
Chemoradiation with or without intraoperative radiation therapy in patients with locally recurrent rectal carcinoma (1999)

The data from the current study suggest that combined modality therapy was well tolerated and improved resectability, local control, and survival. The classification system appears to be a reliable tool with which to predict clinical outcome in patients with locally recurrent rectal carcinoma.
Effect of Zeolite Nano-Materials and Artichoke (Cynara scolymus L.) Leaf Extract on Increase in Urinary Clearance of Systematically Absorbed Nicotine (2012)

Nicotine, the main pharmacologically active component in tobacco and cigarette, has some toxic effects and also high potential for addiction. In this study, the effect of artichoke (Cynara scolymus L.) and zeolite nano-materials on urinary excretion of nicotine and consequently elimination of systematically absorbed nicotine was investigated. A simple, valid and highly sensitive high performance liquid chromatography method has been developed for determination of nicotine in rat urine according to guidelines for bioanalysis.It was found that nano-zeolites can cause increase in urinary concentration of nicotine due to its high surface adsorption. Artichoke leaf extract can cause increase in urinary excretion of nicotine in longer post administration times. It was observed that co-administration of nanozeolites and the leaf extract has the synergetic effect on increasing the urinary excretion of nicotine.
Analysis of cost of performing communications using various communication mechanisms (2002)

There is a trend towards incorporating architectural features which support mechanisms for efficiently communicating long messages and (fixed-size) short messages. In this paper, we provide a framework for analyzing the communication costs in parallel machines which provide various communication mechanisms. First, we define four parameters to accurately model the communication time in these parallel machines. Then, we study the suitability of various mechanisms for performing basic communication operations. Finally, three problems which have very different communication requirements are used as examples to demonstrate the usefulness of our framework in understanding the impact of these communication mechanisms on the communication cost.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Abstract WMP41: Induced Pluripotent Stem Cell Derived Neural Progenitor Therapy for Treatment in a MCAO Ischemic Brain Injury Pig Model (2013)

Background: Adult and embryonic stem cell derived neural progenitor (aNP and eNP) treatments have shown significant promise in rodent models of ischemic brain injury leading to decreased infarct size and improved cognitive and sensorimotor function. However, aNPs are challenging to isolate from live patients and have restricted expansion capabilities and transplant of eNPs would result in immune rejection and bring significant ethical encumbrances being embryonic stem cell derived. Induced pluripotent stem cells (iPSCs) are a new class of stem cells that differentiate into NPs (or iNPs) and can be easily expanded, overcome immune rejection and have no ethical concerns. However, the ability of iNPs to treat ischemic injury remains to be tested. Objective: We proposed to assess iNP function in a middle cerebral artery occlusion (MCAO) pig model that is potentially more predictive of outcomes in human patients than rodents as pigs and humans have similar brain size, white matter composition and both have gyrencephalic brains. Results and Conclusions: We have recently generated iNPs from human and pig iPSCs and have developed a pig MCAO stroke model. Human and pig iNPs show classical NP morphology and express the NP markers SOX1. Further differentiation of NPs demonstrated they were capable of forming all three major lineages of the central nervous system producing βIII-Tub+ neurons, GFAP+ astrocytes and O4+ oligodendrocytes. To test the function of these iNPs in vivo, a Yucatan miniature pig MCAO model was developed by cauterization of the MCA. Diffusion weighted and apparent diffusion coefficient MRI images confirmed stroke damage 1 day post MCAO. Behavioral and motor function analysis supported MRI results with pigs showing reduced neurological capacity indicated by impaired limb movement, abnormal gait, decreased contralateral menace reflex and ipsilateral head turn. The development of a pig MCAO model will allow stringent assessment of efficacy and safety of iNP therapies in a large animal system, providing a critically needed intermediate animal model of stroke that shares key features with humans.
Wide-Band Spectral Control of Au Nanoparticle Plasmon Resonances on a Thermally and Chemically Robust Sensing Platform (2013)

Gold nanoparticles on Al2O3-coated gold films are presented as a chemically and thermally robust platform for molecular sensing. Single particle spectroscopy as a function of Al2O3 coating thickness shows reproducible gold nanoparticle scattering spectra in the range from 690 to 610 nm as the Al2O3 thickness increases from 0 to 3.4 nm. Numerical simulation of these structures indicates that surface-enhanced Raman spectroscopy enhancement factors in excess of 106 can be achieved. The stability of the Al2O3-coated structures under high-power laser irradiation was tested, revealing stable scattering spectra upon irradiation with 100 W/mm2 at the particle resonance wavelength. The presented structure solves challenges with thermal stability, wavelength tuning range, and Raman background signal associated with previously attempted approaches.