gebhart/patrepeval huggingface dataset:
Effects of ethacrynic acid and furosemide on the hormone-mediated adenylate cyclase activation of the hamster kidney. (1978)

The effects of ethacrynic acid and furosemide on the adenylate cyclase activity of the hamster kidney and heart were examined. Ethacrynic acid and furosemide suppressed the vasopressin-mediated increment of adenylate cyclase activity much stronger than the basal activity of the renal medulla. Ethacrynic acid and furosemide strongly suppressed the parathyroid hormone-mediated increment of adenylate cyclase activity on the renal cortex, though furosemide could not inhibit the basal activity of the enzyme. Ethacrynic acid and furosemide suppressed the 1-adrenaline-mediated increment of adenylate cyclase activity of the cardiac muscle, while furosemide could not inhibit the basal activity.Ethacrynic acid and furosemide suppressed the NaF-mediated increment of adenylate cyclase activity of the renal medulla. Thus, these diuretics seem to inhibit the catalytic unit of the enzyme. Ethacrynic acid and furosemide strongly suppressed the hormone-mediated increment of the adenylate cyclase activity, while Ca++ could only depress it to the same degree as it did the basal activity. This difference suggests that these diuretics inhibit not only the catalytic unit of the enzyme, but also other steps of the adenylate cyclase system.Ethacrynic acid and furosemide suppressed the effect of 5'-guanylylimido-diphosphate [Gpp (NH) p] on the adenylate cyclase activation and strongly inhibited the enzyme activity by using the combination of vasopressin and Gpp (NH) p.These results might suggest that ethacrynic acid and furosemide not only affect the catalytic unit of the adenylate cyclase, but also the GTP sensitive site of the enzyme system.
Pyroelectric Infrared Sensor Using PbTiO<SUB>3</SUB> Ceramics (1984)

(Pb, Ca) ((Co1/2W1/2) Ti) O3 ceramic pyroelectric properties have been studied by changing the Ca concentration. With an increase in Ca concentration, the pyroelectric coefficient P and the figure of merit Fv increased and reached 4.43×10-8C cm-2°C-1, and 0.61×10-10C cm J-1, respectively. Pyroelectric properties have been improved to twice the values for the PbTiO3 ceramics. Ca introduction into PbTiO3 ceramics exerts a great influence on the pyroelectric properties.The infrared sensor using this ceramic has been fabricated by hybrid IC technique. The low temperature fired ceramic substrate was used by the advantage of its remarkably low thermal conductivity. The sensor can operate without the load resistance of the pyroelectric element. The maximum responsivity Rv value versus chopping frequency is obtained i a less than 1 Hz frequency range. Responsivity Rv and specific detectivity D* are 780 V/W and 1.1×108cm √Hz/W at 1 Hz, respectively. The sensor is applicable for human body sensing.
Human Herpesvirus 6 Open Reading Frame U83 Encodes a Functional Chemokine (1999)

Some viruses including herpesviruses have undergone evolution to benefit viral infection and propagation by pirating and modifying host genes such as chemokine genes. Human herpesvirus 6 (HHV-6), acutely or persistently infects mononuclear cells in vitro. DNA sequence analysis of HHV-6 has revealed that the putative protein encoded by an open reading frame (ORF) of the U83 gene in HHV-6 variant B resembled a human chemokine. We have cloned the U83 gene and analyzed the biological function of this gene. The U83 gene contained an ORF encoding a 113-amino-acid peptide, starting at the first methionine and containing a possible signal peptide and the typical cysteine residues characteristic of the chemokines. Reverse transcription-PCR analysis of mRNA and immunofluorescent-antibody testing of infected cells both indicated that the encoded protein was a late protein. The ORF U83 gene fused to the Fc gene was expressed as a fusion protein in COS-7 cells by transfection, and the fusion protein was purified from the supernatant of transfected cells to test its biological function. The purified protein was capable of inducing transient calcium mobilization in THP-1 cells and of chemotactically activating THP-1 cells. These findings suggested that the U83 protein might play an important role in HHV-6 propagation in vivo by activating and trafficking mononuclear cells to sites of viral replication, thus aiding the development of superbly efficient virus production mechanisms.
LP MOCVD growth of InAlN/GaN HEMT heterostructure: comparison of sapphire, bulk SiC and composite SiCopSiC substrates for HEMT device applications (2010)

Abstract In this paper we report on low‐pressure metalorganic vapour deposition of InAlN/GaN heterostructures grown on different substrates (Sapphire, bulk SiC, composite SiCopSiC) for HEMT applications, and on first device performances obtained with these heterostructures. Optimisation of the crystal growth on each kind of substrate has led to InAlN/GaN HEMT heterostructures grown on bulk SiC and on composite SiCopSiC substrates which are successfully compared, in terms of material quality, to the standard GaAlN/GaN HEMT heterostructures grown on bulk SiC substrates. First devices based on InAlN/GaN heterostructures grown on bulk SiC exhibit very good microwave performances, with output power of 10.3 W/mm at 10 GHz, similar to those obtained with GaAlN/GaN heterostructures, confirming the promising potential of InAlN material. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Descemet membrane stripping endothelial keratoplasty with neonate donors in two cases (2009)

<h3>Background</h3> Conventional PCR-based direct sequencing of candidate genes for a family with X-linked leucoencephalopathy with unknown aetiology failed to identify any causative mutations. <h3>Objective</h3> To carry out exome sequencing of entire transcripts of the whole X chromosome to investigate a family with X linked leucoencephalopathy. <h3>Methods and results</h3> Next-generation sequencing of all the transcripts of the X chromosome, after liquid-based genome partitioning, was performed on one of the two affected male subjects (the proband) and an unaffected male subject (his brother). A nonsense mutation in <i>MCT8</i> (c.1102A→T (p.R368X)) was identified in the proband. Subsequent PCR-based direct sequencing of other family members confirmed the presence of this mutation, hemizygous in the other affected brother and heterozygous in the proband9s mother and maternal grandmother. <i>MCT8</i> mutations usually cause abnormal thyroid function in addition to neurological abnormalities, but this proband had normal thyroid function. <h3>Conclusion</h3> Single-lane exome next-generation sequencing is sufficient to fully analyse all the transcripts of the X chromosome. This method is particularly suitable for mutation screening of X-linked recessive disorders and can avoid biases in candidate gene choice.
Computation-Assisted Disconnection Approach for the Synthesis of Neoantimycins, 15-Membered Macrocyclic Depsipeptides (2017)

Objective: The objective of this study was to provide experimental chemists with useful guidance for proper choice of a reasonable cyclization precursor in macrolactonization in which there are several options in disconnection analysis. Keywords: Neoantimycin, Prunustatin A, Macrocyclization, DFT calculation, MD simulation.
INTERACTION OF POLYAMIDOAMINE (PAMAM) DENDRIMERS WITH GLASSY CARBON SUPPORTED BILAYER LIPID MEMBRANES (2008)

Electrochemical techniques were used to monitor the formation of a 1,2-dioleoyl-sn-glycero-3-phosphocholine supported bilayer lipid membrane (sBLM) on a glassy carbon electrode and to investigate interactions of polyamidoamine (PAMAM) dendrimers with the sBLM. Dendrimers of generation 2 through generation 4 (G2-G4) did not cause significant damage to the sBLM, whereas G5G7 dendrimers created large defects in sBLM. In cyclic voltammetry studies, the peak current obtained after dendrimer addition was used to estimate the defect area. Impedance spectroscopy showed an increase in capacitance values after addition of G5-G7 dendrimers, consistent with a decrease in sBLM surface coverage. Nanoparticle mass, diameter, and surface charge density all increase significantly with generation number, suggesting that these variables may influence nanoparticles’ ability to rupture sBLM. The method presented here provides a convenient and sensitive way to detect interactions between nanoparticles and lipid bilayers, and may be useful in evaluating nanoparticles’ safety profile or suitability as drug or gene delivery vehicles.
AUTOMATION OF THE SCHONFELD METHOD OF HIGHWAY SURFACE TEXTURE CODE ASSIGNMENT. VOLUME I. THREE DIMENSIONAL CLASSIFICATION TECHNIQUE INTRODUCTION AND SUMMARY (1975)

The research involved development of a system for measurement and automatic classification of pavement surface texture properties in accordance with the Schonfeld method. Electronic stereophotogrammetric techniques were adapted to obtain digital data defining the surface from stereophotographs. Algorithms were then developed to process this data on a computer and classify the surface texture automatically. Preliminary designs of camera systems, which could be mounted on a highway vehicle and collect the required data, were developed and shown to be feasible. The automated procedure allows a much more comprehensive and detailed investigation of surface texture to be carried out than the previously available manual method. Comprehensive information about pavement texture can provide valuable data for studying skid resistance characteristics and monitoring wear and polishing of pavements.
Effective Control Method of Power Compensator with Lithium-Ion Battery for DC Railway System (2006)

A new and effective control method of a power compensator with a lithium-ion battery for D.C railway systems has been developed in this paper. A compensator stores regenerated energy into the battery, and discharges to powering trains for stabilizing line voltage and for improving the compensator efficiency of the railway system. The charging and discharging currents are controlled according to the line voltage, although the instantaneous charging power of the lithium-ion battery is heavily depends on its SOC (state of charge). The conventional control method requires an additional SOC regulator to track the optimal operating point. The proposed method increases the maximum discharge current proportional to the SOC, and automatically keeps the maximum power without the SOC regulator. Numerical simulations are carried out for the final design of the power compensator. The results show that the proposed method improves the efficiency of the compensator compared with that of the conventional system.
Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase (2002)

The RING finger of BRCA1 confers ubiquitin ligase activity that is markedly enhanced when complexed with another RING-containing protein, BARD1, and is required for the function of this tumor suppressor protein in protecting genomic integrity. Here, we report that co-expression of BRCA1-(1-639) and BARD1 in bacteria can assemble a potent ubiquitin ligase activity. Purified BRCA1-(1-639)*BARD1 stimulated the Ubc5c-mediated monoubiquitination of histone H2A/H2AX in vitro, suggesting a possible role for BRCA1*BARD1 in modifying chromatin structure. Moreover, the truncated BRCA1*BARD1 complex exhibited efficient autoubiquitination activity in vitro capable of assembling non-lysine 48-linked polyubiquitin chains on both BRCA1-(1-639) and BARD1. When co-expressed in cells by transient transfection, the recombinant BRCA1-(1-300).BARD1 complex was found to be associated with polyubiquitin chains, suggesting that BRCA1-(1-300)*BARD1 was ubiquitinated in vivo as well. These results raise the possibility that BRCA1*BARD1 acts to assemble non-lysine 48-linked polyubiquitin chains that may serve as part of a signaling platform required for coordinating DNA repair-related events.
Unsteady states in metallurgical sulphuric acid plants after SO<sub>2</sub> concentration drop in the feed gas (1996)

Abstract The paper presents results of dynamic mathematical model simulations for selected two characteristic flowsheets of metallurgical SO 2 oxidation plant after temporary decrease of reactant concentration in the feed gas. An analysis of dynamic resistance of the plant for the concentration drop, from the point of view of the dynamic autothermal properties is given.
A contour tracking method using an elastic contour model and an energy‐minimization approach (1993)

Abstract This paper proposes a method for tracking an object contour in a sequence of images. In this method, a contour model is defined by elastics. The contour tracking problem is formulated as an optimization problem to find the position that minimizes both the elastic energy of its model and the potential energy derived from the edge potential image that includes a target object contour. The contour model is updated sequentially according to the tracking result in the previous frame. In the proposed approach, the contour model not only moves toward the object contour in the current frame, but also preserves the shape of the tracked contour in the previous frame. Therefore, the proposed method makes it possible to establish object tracking even when complex texture and occluding edges exist in or near the target object. Moreover, in this method, since smooth potential fields extending over a long distance are generated by distance transformation, unlike conventional methods, long‐range motion tracking can be performed. An algorithm is newly presented which efficiently solves energy minimization problems. The validity and usefulness of the proposed method is shown with some experimental results.
A Step-indexed Semantics of Imperative Objects (2009)

Step-indexed semantic interpretations of types were proposed as an alternative to purely syntactic proofs of type safety using subject reduction. The types are interpreted as sets of values indexed by the number of computation steps for which these values are guaranteed to behave like proper elements of the type. Building on work by Ahmed, Appel and others, we introduce a step-indexed semantics for the imperative object calculus of Abadi and Cardelli. Providing a semantic account of this calculus using more `traditional', domain-theoretic approaches has proved challenging due to the combination of dynamically allocated objects, higher-order store, and an expressive type system. Here we show that, using step-indexing, one can interpret a rich type discipline with object types, subtyping, recursive and bounded quantified types in the presence of state.
Online/In Print: Book Review (2001)

ADVERTISEMENT RETURN TO ISSUEPREVDepartmentsNEXTOnline/In Print: Book ReviewA review of Aerosol Chemical Processes in the EnvironmentCharles E. KolbCite this: Environ. Sci. Technol. 2001, 35, 3, 83APublication Date (Web):February 1, 2001Publication History Published online1 February 2001Published inissue 1 February 2001https://pubs.acs.org/doi/10.1021/es012272nhttps://doi.org/10.1021/es012272nnewsACS Publications. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views163Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (6 MB) Get e-Alertsclose Get e-Alerts
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ChemInform Abstract: AN IMPROVED CONVERSION OF CYCLOHEXANONES INTO 1‐METHYL‐2‐FORMYLCYCLOHEXENES (1975)

Abstract Das Cyclohexanon (I) wird in das Hydroxymethylenderivat (II) umgewandelt, das mit Isopropanol in siedendem Benzol in Gegenwart von p‐Toluolsulfonsäure zu 2‐ Isopropoxymethylen‐cyclohexanon (III) reagiert.
DNA loops specify p53 network responses (2014)

Click to increase image sizeClick to decrease image sizeKeywords:: p53genome architectureenhancerschromatin loopsReaperThis article is related to:
Structural Dependencies between Syntactic Relations: A Robust Parsing Model for Extrapositions in Spontaneous Speech (1999)

Typical grammatical constructions in spontaneous German speech are extrapositions which are discontinuous constructions where constituents occur in the Nachfeld. Structural dependencies between the source sentence and the extraposed constituent are claimed to govern all interpretations induced by extraposed constituents to the source sentence. The model proceeds recursively by integrating the extraposed constituent in the source sentence due to the syntactic relations between reference and extraposed constituent. The parsing strategy is robust to out-of-vocabulary words, to speech recognition errors by morphologically similar words and to some kinds of deletions.
Effects and mechanisms of artesunate on immunological hepatic fibrosis in experimental rats (2011)

Aim To investigate the effects and mechanisms of artesunate on immunological hepatic fibrosis in experimental rats.Methods The model of immunological hepatic fibrosis induced by bovine serum albumin was prepared.The rats were randomly divided into 6 groups: the normal group,the model group,the positive control group treated by colchicine(0.1 mg·kg-1),and the three artesunate groups(5,15,45 mg·kg-1).The pathological morphology of liver was examined by masson trichrome stain and the content of Hyp were analyzed via jamall′s method;The expressions of TGF-β1 mRNA and α-SMA mRNA in liver were detected by RT-PCR.Hepatic stellate cells(HSC-T6) were incubated in vitro,stimulated by TGF-β1(5 μg·L-1) and treated with different concentrations of Art(6.25,25,50 mg·L-1) for 24 h.The expressions of procollagen Ⅰ mRNA and collagen Ⅰ protein in HSC-T6 cells were separately determined by RT-PCR and Western blot.Results The degree of hepatic fibrosis and the content of Hyp in artesunate group were reduced in comparison with that of the model group.The expressions of TGF-β1 mRNA and α-SMA mRNA were decreased in artesunate groups.The expressions of procollagen Ⅰ mRNA and collagen Ⅰ protein were down-regulated in artesunate groups.Conclusion Artesunate significantly inhibited the progress of hepatic fibrosis in experimental rats,probably by inhibiting the activation of HSC and down-regulating the expression of TGF-β1 mRNA and collagenⅠprotein.
Channel mobility of GeSi quantum-well P-MOSFETs (2002)

The results of channel mobility of a GeSi quantum-well PMOS from 8 K to 300 K are presented. As the temperature is lowered below 25 K, the field effect channel mobility sharply increases with lowering of the temperature. The mobility at 8 K is found to be 3 times higher than that at 25 K. At very low temperature ( approximately 10 K), the transition of channel transconductance with gate voltage from a high (GeSi channel) to a low (surface channel) value has been clearly observed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The effect of nerve growth factor on cycle AMP levels in superior cerival ganglia of the rat. (1975)

Nerve growth factor (NGF) produces a several-fold increase in the cyclic AMP concentration in rat superior cervical ganglia in organ culture within 5 min. An increase can be seen with as little as 40 ng/ml of NGF. Oxidized NGF is without effect. The increase in the cAMP concentration produced by NGF is prevented by the addition of antiserum to NGF.
Analysis of protein targets in pathogen–host interaction in infectious diseases: a case study on Plasmodium falciparum and Homo sapiens interaction network (2017)

Infection and disease progression is the outcome of protein interactions between pathogen and host. Pathogen, the role player of Infection, is becoming a severe threat to life as because of its adaptability toward drugs and evolutionary dynamism in nature. Identifying protein targets by analyzing protein interactions between host and pathogen is the key point. Proteins with higher degree and possessing some topologically significant graph theoretical measures are found to be drug targets. On the other hand, exceptional nodes may be involved in infection mechanism because of some pathway process and biologically unknown factors. In this article, we attempt to investigate characteristics of host-pathogen protein interactions by presenting a comprehensive review of computational approaches applied on different infectious diseases. As an illustration, we have analyzed a case study on infectious disease malaria, with its causative agent Plasmodium falciparum acting as 'Bait' and host, Homo sapiens/human acting as 'Prey'. In this pathogen-host interaction network based on some interconnectivity and centrality properties, proteins are viewed as central, peripheral, hub and non-hub nodes and their significance on infection process. Besides, it is observed that because of sparseness of the pathogen and host interaction network, there may be some topologically unimportant but biologically significant proteins, which can also act as Bait/Prey. So, functional similarity or gene ontology mapping can help us in this case to identify these proteins.
Genetic Signatures from Amplification Profiles Characterize DNA Mutation in Somatic and Radiation-induced Sports of Chrysanthemum (1998)

The chrysanthemum ( Dendranthema grandiflora Tzvelev.) cultivars `Dark Charm', `Salmon Charm', `Coral Charm' and `Dark Bronze Charm' are either radiation-induced mutants or spontaneous sports of `Charm' and constitute a family or series of plants that primarily differ in flower color. These cultivars, which were difficult to differentiate genetically by DNA amplification fingerprinting (DAF), were easily identified by using arbitrary signatures from amplification profiles (ASAP). Genomic DNA was first amplified with three standard octamer arbitrary primers, all of which produced monomorphic profiles. Products from each of these DNA fingerprints were subsequently reamplified using four minihairpin decamer primers. The 12 primer combinations produced signatures containing ≈37% polymorphic character loci, which were used to estimate genetic relationships between cultivars. Forty-six (32%) unique amplification products were associated with individual cultivars. The number of ASAP polymorphisms detected provided an estimate of the mutation rate in the mutant cultivars, ranging from 0.03% to 1.6% of nucleotide changes within an average of 18 kb of arbitrary amplified DAF sequence. The ASAP technique permits the clear genetic identification of somatic mutants and radiation-induced sports that are genetically highly homogeneous and should facilitate marker assisted breeding and protection of plant breeders rights of varieties or cultivars.
ChemInform Abstract: ELECTROCHEMICAL SYNTHESIS OF CYCLIC HYDROXAMIC ACIDS FOLLOWED BY BAMBERGER REARRANGEMENT (1982)

Abstract Die Elektroreduktion der Nitrophenylthioessigsäure (Ia) führt zur Hydroxamsäure (II) sowie dem Umlagerungsprodukt (IIIa), das mit steigender Elektrolysetemp.