gebhart/patrepeval huggingface dataset:
Fenóis totais, flavonoides totais e atividade antioxidante de Selaginella convoluta (Arn.) Spring (Selaginellaceae) (2012)

Selaginella convoluta é uma espécie conhecida no Nordeste do Brasil como “jericó”, e bastante utilizada na medicina popular para tratamento de doenças. Este estudo teve como objetivo determinar o teor de compostos fenólicos e avaliar a atividade antioxidante in vitro do extrato etanólico e das frações obtidas por partição de S. convoluta. O conteúdo de fenóis totais foi determinado pelo método de Folin-Ciocalteu. O teor de flavonoides totais também foi avaliado. A atividade antioxidante dos extratos foi avaliada usando o método do sequestro do radical DPPH e inibição da auto-oxidação do sistema β-caroteno-ácido linoleico e comparada com os compostos de referência ácido ascórbico, BHA, BHT, quercetina e pirogalol. O conteúdo fenólico total foi de 209,90 ± 19,84 e 61,13 ± 2,50 mg equivalente de ácido gálico/g para os extratos AcOEt e EEB, respectivamente. O conteúdo de flavonoides totais foi de 155,70 ± 6,21 e 62,13 ± 4,10 para os dois extratos, respectivamente. Os extratos AcOEt e EEB apresentaram boas atividades antioxidantes. BHA foi o antioxidante mais efetivo, com um valor de IC50 de 1,62 ± 0,69 µg/mL. Os resultados obtidos mostram que S. convoluta pode ser uma boa fonte de compostos fenólicos antioxidantes. Estudos posteriores serão realizados para se chegar ao isolamento e identificação dos principais constituintes fenólicos dos extratos.
Synthesis and characterization of silver(i) adducts supported solely by 1,3,5-triazapentadienyl ligands or by triazapentadienyl and other N-donors (2011)

Halogenated 1,3,5-triazapentadienyl ligands [N{(C(3)F(7))C(C(6)F(5))N}(2)](-), [N{(CF(3))C(C(6)F(5))N}(2)](-) and [N{(C(3)F(7))C(2,6-Cl(2)C(6)H(3))N}(2)](-), alone or in combination with other N-donors like CH(3)CN, CH(3)(CH(2))(2)CN, and N(C(2)H(5))(3), have been used in the stabilization of thermally stable, two-, three- or four-coordinate silver(i) adducts. X-Ray crystallographic analyses of {[N{(C(3)F(7))C(C(6)F(5))N}(2)]Ag}(n), {[N{(C(3)F(7))C(C(6)F(5))N}(2)]Ag(NCCH(3))}(n), {[N{(C(3)F(7))C(2,6-Cl(2)C(6)H(3))N}(2)]Ag(NCCH(3))}(n), {[N{(CF(3))C(C(6)F(5))N}(2)]Ag(NCCH(3))(2)}(n) and {[N{(C(3)F(7))C(C(6)F(5))N}(2)]Ag(NCC(3)H(7))}(n) revealed the presence of bridging 1,3,5-triazapentadienyl ligands bonded to silver through terminal nitrogen atoms. These adducts are polymeric in the solid state. [N{(C(3)F(7))C(2,6-Cl(2)C(6)H(3))N}(2)]AgN(C(2)H(5))(3) is monomeric and features a 1,3,5-triazapentadienyl ligand bonded to Ag(I) in a κ(1)-fashion via only one of the terminal nitrogen atoms. The solid state structure of [N{(C(3)F(7))C(C(6)F(5))N}(2)]H has also been reported and it forms polymeric chains via inter-molecular N-H···N hydrogen-bonding.
Histopathologic classification of small cell lung cancer changing concepts and terminology (1988)

Considerable attention has been devoted to the diagnosis of small cell lung carcinoma (SCLC) and its subtypes. In the literature contradictory opinions have been published concerning the clinical implications of subtyping, largely because of the different criteria used by different pathologists. This article is a consensus report by the Pathology Committee of the International Association for the Study of Lung Cancer. The following classification of SCLC is recommended: (1) Small cell carcinoma. This subtype includes most of the tumors previously included in the oat cell and intermediate subtypes. More than 90% of untreated SCLC fall into this category. (2) Mixed small cell/large cell carcinoma. This subtype, which may be associated with a poor prognosis and response to therapy, contains a spectrum of cell types ranging from typical SCLC to larger cells having prominent nucleoli and resembling large cell carcinoma. (3) Combined small cell carcinomas. Typical SCLC elements are intimately admixed with areas of differentiated squamous cell or adenocarcinoma. This simplified classification of SCLC will facilitate uniformity in the diagnosis and further our understanding of the clinical significance of the rarer SCLC with variant morphologies.
Affordances in Psychology, Neuroscience, and Robotics: A Survey (2016)

The concept of affordances appeared in psychology during the late 60s as an alternative perspective on the visual perception of the environment. It was revolutionary in the intuition that the way living beings perceive the world is deeply influenced by the actions they are able to perform. Then, across the last 40 years, it has influenced many applied fields, e.g., design, human-computer interaction, computer vision, and robotics. In this paper, we offer a multidisciplinary perspective on the notion of affordances. We first discuss the main definitions and formalizations of the affordance theory, then we report the most significant evidence in psychology and neuroscience that support it, and finally we review the most relevant applications of this concept in robotics.
An Iterative Improvement Procedure for Hierarchical Clustering (2003)

We describe a procedure which finds a hierarchical clustering by hill-climbing. The cost function we use is a hierarchical extension of the k-means cost; our local moves are tree restructurings and node reorderings. We show these can be accomplished efficiently, by exploiting special properties of squared Euclidean distances and by using techniques from scheduling algorithms.
Automated assessment of English fundamental frequency contours for non-native speakers from China and India (2013)

This study investigates the F0 contours produced by non-native speakers of English from two different countries. Speakers from China (N = 202; L1 Mandarin) and India (N = 230; multiple L1s) read a paragraph out loud in the context of an assessment of non-native English speaking proficiency; in addition, a control set of native speakers (N = 85) read the same paragraph. The words and phonemes in all of the responses were provided with time stamps using forced alignment with the prompt text, and mean normalized F0 values were extracted for each word from each speaker. A model F0 template for the paragraph was generated by taking the mean word-level F0 value across all native speakers, and the correlation between the word-level F0 contour and this template was calculated for each non-native speaker (as in Schwanenflugel et al. 2004). This correlation was used as a feature for assessing F0 contours and was correlated with expert human scores of English proficiency. The results demonstrated that the feature performed somewhat better for the speakers from India (r = 0.390) than the speakers from China (r = 0.326). Furthermore, the correlations improved when function words were removed from the analysis and only content words were considered (r = 0.396 and r = 0.346).
THE EFFECTS OF SHAPE OF LOAD PULSE ON SHOCK-MITIGATING CHARACTERISTICS OF A STYROFOAM PLASTIC, (1965)

Abstract : The dynamic cushioning characteristics of confined specimens of Styrofoam HD-1 are presented in the form of stress-strain curves and stress-time curves. The specimens demonstrated identical stress-strain curves from various impulse loadings on the HYGE shock tester and from static tests. Variations in the rise time and pulse durations of the HYGE wave forms were accompanied by like variations in rise times and durations of the crushing stress-time curves. Styrofoam HD-1 crushed initially at approximately 46 psi and bottomed at about 50 per cent strain with an energy dissipation at bottoming of approximately 3 ft-lb per cubic inch. (Author)
Proton irradiation effects in MOS junction field-effect transistors and integrated circuits (1966)

Proton irradiation effects in MOS and junction field-effect transistors and integrated circuits
Development of electrochemical noninvasive glucose nanobiosensor using antioxidants as a novel mediator (2017)

Abstract Diabetes mellitus is a chronic disease, and millions of people die from its related disorders each year; thus, people with diabetes have to control the level of blood glucose frequently. In the last decade, the noninvasive biosensors have been considered to track glucose level without finger pricking. In this research, the glucose biosensor was developed using a new formulation containing hydroxylmethoxyphenyl derivation as a novel mediator that was extracted from a natural source. The mediator characterization was performed by means of thin‐layer chromatography and Fourier transform infrared spectroscopy, and the electrochemical activity of the prepared biosensor was evaluated by Autolab potentiostate machine. Scanning electron microscope micrographs revealed a flat surface on the modified electrode that is crucial in electron conduction equivalence. The cyclic voltammetry examination ascertained the irreversible oxidative reaction of phenolic mediator that leads the biosensor system to more electron formation. The obtained results demonstrated that antioxidants could improve the electron forming and also it could enhance the current signal. Finally, response time could be controlled by variation in polyvinyl alcohol concentration.
Asymmetric Total Synthesis of PDIM A: A Virulence Factor of <i>Mycobacterium tuberculosis</i> (2008)

An array of efficient catalytic transformations has been employed for the first stereoselective total synthesis of the lipid phthiocerol dimycocerosate A (PDIM A). It has been shown previously that this cell-wall-associated lipid, the structure of which has now been confirmed, is required for Mycobacterium tuberculosis virulence.
The International Linear Collider Technical Design Report - Volume 3.II: Accelerator Baseline Design (2013)

The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using Niobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a 'push-pull' configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to increase significantly our understanding of the fundamental processes that govern the evolution of the Universe.
Process engineering tools to guide implementation and scale-up of transaminase cascades (2012)

Biocatalysis is gaining ground in the pharmaceutical and fine chemical industry as a selective and potentially green technology to help synthesize industrially interesting products. In particular in the last decade the application of transaminases (E.C. 2.6.1.X ) has gained particular attention as a means to synthesize optically pure chiral amines from prochiral ketones using an amine donor. Chiral amines can also be synthesized by other routes but the importance of the compounds mean that a variety of routes will be required to cover the synthesis of many different chiral amines of different properties and values. A major challenge in the transaminase catalysed synthesis of chiral amines is the unfavourable equilibrium position [1]. There are several solutions to such equilibrium problems, including the use of in-situ product removal (ISPR) and cascade reactions to degrade or recycle the co-product formed. Such techniques, especially those using cascades can be a great tool to overcome the thermodynamic hurdle, but also present some new challenges with respect to compatibility of reaction conditions, recycling of co-factors and last but not least, the added cost of the cascade system components [2]. In this lecture we will present several process engineering tools including the use of mathematical modelling, uncertainty and sensitivity analysis [3] as well as economic evaluation and defined experimental protocols to help evaluate the feasibility of new biocatalytic cascades. The concepts will be illustrated with data from transaminase catalysed syntheses we have been modelling and studying experimentally at DTU.
Fingerprints in Silicon: Towards a low-cost fingerprint detector (2008)

Several years ago the Circuit and System group started an MSc project with the goal of finding an optimal electronic system architecture which would be capable of identifying a person based on its fingerprint. Suppose that we can succeed to design a ‘personal smart card’, which is activated based on fingerprint technology, then we can forget about ‘PIN codes’ and related security problems.
Modalité thérapeutique de l’occlusion veineuse centrale chez les patients porteurs d’un pace-maker cardiaque (2001)

info:eu-repo/semantics/nonPublished
hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci (2001)

Proliferating cell nuclear antigen (PCNA) has been implicated in eukaryotic postreplicative mismatch correction, but the nature of its interaction with the repair machinery remained enigmatic. We now show that PCNA binds to the human mismatch binding factors hMutSalpha and hMutSbeta via their hMSH6 and hMSH3 subunits, respectively. The N-terminal domains of both proteins contain the highly conserved PCNA-binding motif Qxx[LI]xx[FF]. A variant of hMutSalpha, lacking this motif because of deletion of 77 N-terminal residues of the hMSH6 subunit, no longer was able to interact with PCNA in vitro and failed to restore mismatch repair in hMSH6-deficient cells. Colocalization of PCNA and hMSH6 or hMSH3 to replication foci implies an intimate link between replication and mismatch correction. We postulate that PCNA plays a role in repair initiation by guiding the mismatch repair proteins to free termini in the newly replicated DNA strands.
Lectin-induced aggregation of glycophorin-reconstituted liposomes. (1987)

今回著者らは,リボソームの構造強化と同時にリボソームへの認識機能の付与のため新しく開発した人工境界脂質(1,2-ジミリストィルアミド-1,2-デオキシホスファチジルコリン(以下DDPCと略記する)を用いて脂質二分子膜中にグリコホリンを組み込んだリボソームを作成した。Egg-PC(80mol%)とDDPC(20mol%)の混合脂質リボソームにグリコホリンを組み込むと通常のEgg-PCリボソームの10倍近い保持率が得られた。DDPCを共存させた脂質二分子膜中への膜糖タンパク質の保持効果は天然のスフィソゴミエリン(SPM)よりも優れていた。ついでこのリポソーム上のグリコホリンの糖鎖末端をノイラミニダーゼ処理し,シアル酸残基からガラクトース残基へ,またN-アセチルガラクトサミニダーゼで処理することにより全糖鎖を除去した。マンノースおよびグルコース特異性のコンカナパリンA(ConA)では,シアル酸除去および酵素未処理グリコホリン存在リポンームのいずれもがまったく凝集を示さなかった。しかし, シアル酸結合レクチン(ニホンカブトガニレクチン, TTA)は,グリコホリン存在リボソームに対して高い凝集性を示した。また,部分的にシアル酸残基を除去したグリコホリン存在リボソームでは凝集性の低下が見られた。これらの結果は, リボソーム表面上の糖タンパク質糖鎖による認識機能発現の可能性を示唆するものである。
Protein profiles and identification of high performance liquid chromatography isolated proteins of cancer cell lines using matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (1998)

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has been used to rapidly profile the protein content of human cell lysates from MCF-10 cell and variant lines.The method was used to study the protein profiles of these cells as they progressed from normal breast epithelium to fully malignant cells.Distinct differences in the protein profiles were observed with progression, and specific proteins associated with carcinogenesis (p53, c-myc, and c-erbB-2) were heavily expressed in these cells as detected by MALDI-TOFMS.These proteins were also isolated using non-porous reversed-phase high performance liquid chromatography (NP-RP-HPLC) and mass analyzed by MALDI-TOFMS to provide molecular weight information without interference from other proteins in the whole cell lysates, and to avoid suppression effects in mixtures of proteins detected by MALDI-TOFMS.In order to confirm the identity of these oncoproteins, the cell lysates were subjected to one-dimensional (1-D) gel separation and subsequently electroblotted onto a poly(vinylidene difluoride) (PVDF) membrane for further analysis.Trypsin and cyanogen bromide digestions were performed on these proteins eluted from excised PVDF bands which were then analyzed by MALDI-TOFMS.The identity of these proteins was confirmed by database matching procedures.
EFFECTS OF TEMPERATURE AND TICK WEIGHT ON EXPRESSION OF AUTOGENY IN THE ARGASID TICK ORNITHODOROS PARKERI (1984)

The effects of different temperatures on the expression of autogenic development in unfed/mated Ornithodoros parkeri Cooley females were examined. High temperature (29 C) induced autogeny in lower, middle and higher weight classes (11-20, 21-30, 31-40 mg, respectively) with all females in the highest weight class and most in the middle weight class ovipositing within 51 days post-mate. At a lower temperature (21 C) autogenic development was not expressed by higher and middle weight females, whereas lower weight females exhibited similar degrees of autogeny at both temperatures. Results are discussed in relation to presumptive factors involved in the control and mediation of autogeny.
All-fiber burst mode laser system integrated with OCT for cataract surgery (2015)

We demonstrate a burst-mode Yb all-fiber femtosecond laser system integrated with OCT for cataract surgery and aim to enhance further the procedure with lower collateral tissue damage, cleaner, efficient cuts with compact and robust structure.
Generic Simulation Approach for Multi-Axis Machining: Part I—Modeling Methodology (2000)

Abstract This paper presents a new methodology for analytically simulating multi axis machining of complex sculptured surfaces. A generalized approach is developed for representing an arbitrary cutting edge design, and the local surface topology of a complex sculptured surface. A NURBS curve is used to represent the cutting edge profile. This approach offers the advantages of representing an arbitrary cutting edge design in a generic way, as well as providing standardized techniques for manipulating the location and orientation of the cutting edge. The local surface topology of the part is defined as those surfaces generated by previous tool paths in the vicinity of the current tool position. The local surface topology of the part is represented without using a computationally expensive CAD system. A systematic prediction technique is then developed to determine the instantaneous tool/part interaction during machining. The methodology employed here determines cutting edge in-cut segments by determining the intersection between the NURBS curve representation of the cutting edge and the defined local surface topology. These in-cut segments are then utilized for predicting instantaneous chip load, static and dynamic cutting forces, and tool deflection. Part I of this paper details the modeling methodology and demonstrates the capabilites of the simulation for machining a complex surface. Part II details both the model calibration procedure and discusses a case study of process optimization through feed rate scheduling.
Multimerization of Surfactant Protein D, but Not Its Collagen Domain, Is Required for Antiviral and Opsonic Activities Related to Influenza Virus (2008)

Surfactant protein D (SP-D) plays important roles in the initial innate defense against influenza A virus (IAV). The collagen domain of SP-D is probably critical for its homeostatic functions in vivo and has been implicated in the modulation of macrophage responses to SP-D-ligand complexes. For the current studies, we used a panel of rat SP-D mutants lacking all or part of the collagen domain to more specifically evaluate the contributions of this domain to viral interactions. SP-D multimers lacking the collagenous sequence efficiently neutralized Phil82 IAV, promoted neutrophil uptake of IAV, and also potentiated the IAV-induced neutrophil respiratory burst response. A dodecameric mutant with shortened collagenous arms showed enhanced viral aggregation and neuraminidase inhibition, and an increased capacity to inhibit a partially collectin-resistant strain of IAV. By contrast, truncated molecules lacking an N-terminal and collagen domain showed no detectable antiviral and opsonizing activity, despite preservation of lectin activity and detectable viral binding. Thus, multimerization, which is mediated by the N-peptide, is more important than the collagen domain for efficient viral neutralization and opsonization. However, the structure of the collagen domain significantly influences the anti-viral activity of multimerized forms of SP-D.
A Case of Ankylosing Spondylitis Accompanied by Henoch-Schönlein Purpura and Chronic Inflammatory Demyelinating Polyneuropathy (2012)

ì ìë¤ì í¼ë¶ ìë°ê³¼ ì ì§ì ì¸ íì§ ê·¼ë ¥ ì½íë¥¼ ì£¼ìë¡ ë´ìí ê°ì§ì± ì²ì¶ì¼ íììì í¤ë ¸í-ì¤ë¼ì¸ ìë°ì¦ì ì§ë¨íê³ , ìì ì¦ì, ì ê¸°ìë¦¬íì  ê²ì¬ ë° ì ê²½ ì¡°ì§ ê²ì¬ë¥¼ íµí´ ë§ì± ì¼ì¦ì± íìì´ì± ë¤ë° ì ê²½ë³ì¦ì´ ëë°ë íìë¥¼ ê²½ííìê¸°ì ë¬¸íê³ ì°°ê³¼ í¨ê» ë³´ê³ íë ë°ì´ë¤. ì¤ì¬ ë¨ì´: í¤ë ¸í-ì¤ë¼ì¸ ìë°ì¦; ë¤ë°ì ê²½ê·¼ë³ì¦; ê°ì§ì± ì²ì¶ì¼
Chemokine Receptor Antagonists (2012)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTChemokine Receptor AntagonistsJames Pease† and Richard Horuk*‡View Author Information† Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London SW7 2AZ, U.K.‡ Department of Pharmacology, University of California—Davis, 451 Health Sciences Drive, Davis, California 95616, United States*Phone: 925-708-0358. E-mail: [email protected]Cite this: J. Med. Chem. 2012, 55, 22, 9363–9392Publication Date (Web):August 29, 2012Publication History Received15 May 2012Published online24 September 2012Published inissue 26 November 2012https://doi.org/10.1021/jm300682jCopyright © 2012 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views4724Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (2 MB) Get e-AlertsSUBJECTS:Antagonists,Immunology,Pharmaceutics,Receptors,Rodent models Get e-Alerts
Carotid Sinus Hypersensitivity and Syncope in Elders (2006)

The most common cause of syncope and falls in elders is carotid sinus hypersensitivity (CSH). To determine CSH prevalence in an unselected population