gebhart/patrepeval huggingface dataset:
[Comparative hemodynamic study of anesthesia induction with propofol (Diprivan), thiopental, methohexital, etomidate and midazolam in patients with coronary disease]. (1987)

In a randomized study we investigated the hemodynamic effects of intravenous induction with propofol (2 mg/kg body wt.), thiopental (5 mg/kg), methohexital (1 mg/kg), etomidate (0.3 mg/kg), and midazolam (0.15 mg/kg) in 50 patients undergoing coronary artery bypass grafting. All patients were premedicated with flunitrazepam (0.03 mg/kg up to 2 mg) and morphine hydrochloride (0.2 mg/kg up to 15 mg) 100 min before the investigation. After 0.003 mg/kg fentanyl the patients received the induction agent in the above-mentioned dosage within 40 s followed by 0.1 mg/kg pancuronium bromide. Hemodynamic measurements were performed 1, 3, and 5 min after the end of the injection as well as 1 and 5 min after intubation.(ABSTRACT TRUNCATED AT 250 WORDS)
A Fresh Look at the Staudinger Reaction on Azido Esters: Formation of 2<i>H</i>-1,2,3-Triazol-4-ols from α-Azido Esters Using Trialkyl Phosphines (2016)

Phenyl esters of α-azido acids react with trialkylphosphines in THF/H2O to give 5-substituted 2H-1,2,3-triazol-4-ols in good to excellent yields. In contrast, their reaction with PPh3 in THF/H2O give the amino esters as the major product and no triazoles. Reaction between an α-azido phenyl ester and P(OEt)3 provided the corresponding phosphoramidate in excellent yield, but no triazole was formed.
ChEBI: a database and ontology for chemical entities of biological interest (2007)

Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. The molecular entities in question are either natural products or synthetic products used to intervene in the processes of living organisms. Genome-encoded macromolecules (nucleic acids, proteins and peptides derived from proteins by cleavage) are not as a rule included in ChEBI. In addition to molecular entities, ChEBI contains groups (parts of molecular entities) and classes of entities. ChEBI includes an ontological classification, whereby the relationships between molecular entities or classes of entities and their parents and/or children are specified. ChEBI is available online at http://www.ebi.ac.uk/chebi/
The generation of nondiffracting beams using inexpensive computer-generated holograms (2006)

We present a simple experimental procedure for producing a computer-generated hologram of good quality. As an example, the transverse intensity and phase structure of nondiffracting beams is investigated.
Inflammation induced by mycolic acid-containing glycolipids of Mycobacterium bovis (BCG). (1985)

Mycobacterium bovis (BCG) was submitted to lipid extraction involving gentle and drastic procedures. Neutral lipids, glycolipids as well as phospholipids were detected in the diethyl ether extract, whereas the chloroform and chloroform-methanol extracts contained mainly phospholipids. Arabinose mycolates, which represent firmly bound cell wall lipids, were detected in the acidified ether extract. The lipid extracts were adsorbed to charcoal particles and inoculated intravenously into mice. Histological analysis showed that the particles were trapped in the lung microcirculation and strong inflammatory reactions were induced around the charcoal particle coated lipids present in the diethyl ether, chloroform and acidified diethyl ether extracts. Fractionation of these inflammation-inducing extracts by column and preparative thin-layer chromatography led to the isolation of five active mycolic acid-containing glycolipids, identified as glycerol monomycolate, glucose monomycolate, arabinose monomycolate, trehalose monomycolate and trehalose dimycolate on the basis of physical, chemical and spectroscopic analyses. Inflammatory reactions similar to that observed after inoculation of live BCG were induced in the lungs by trehalose monomycolate, trehalose dimycolate or glucose monomycolate. However, the toxic reactions caused by glycerol monomycolate and arabinose monomycolate were characterized by an acute inflammatory process mainly due to the constant and massive presence of polymorphonuclear leukocytes.
The Erlangen micro-lightguide spectrophotometer EMPHO I (1989)

The Erlangen micro-lightguide spectrophotometer EMPHO 1 was designed for fast diffuse reflection (remission) spectrophotometry in small tissue volumes. The aim was to construct a compact, modular instrument with a high repetition rate which can be adapted to moving organs, e.g. the beating heart in situ, by the use of highly flexible micro-lightguides. Focusing problems, which cannot be solved when conventional optical devices such as microscopes are used in moving tissues, become negligible. A bandpass interference filter disk, which is rotated by a motor serves as a monochromating unit. One diffuse reflection spectrum in a selected wavelength domain is recorded during each revolution of the motor. Special filter disks, with spectral ranges of 400-520, 500-630, 600-1200 nm can be used for different tasks. The monochromated light is transmitted by means of a flexible fluid-lightguide to a photomultiplier tube. The electrical signal, which is proportional to the light intensity is recorded by an IBM-compatible AT. An analogue to digital converter has been developed for the AD conversion. Sampling of the spectra occurs in steps of 2 nm triggered by a decoding unit, containing an EPROM where the function between the wavelength-angular position characteristic of the filter disk is stored. A decoder wheel mounted on the same axle as the driving motor is used to program the decoder unit and to recall the wavelength position function. The decoding procedure enables a high wavelength reproducibility to be attained. The monochromating device allows a sampling velocity of 100 spectra per second. The EMPHO I has been successfully applied to experiments in the beating heart, the brain, the eye, the liver, the small intestine and the skeletal muscle of mammals. First investigations have also been performed in the heart during open heart surgery and in human skin. The apparatus has a high sampling rate and the small catchment volume allows measurements of remission spectra in tissue volumes supplied by only a few capillaries. The absolute oxygenation and the relative haemoglobin concentration can be determined by on-line computer evaluation of the recorded spectra and displayed on a screen.
Recent progress in circulation control aerodynamics (1987)

A workshop on circulation control aerodynamics was held on February 19-21, 1986 at NASA Ames Research Center, Moffett Field, CA. The subjects covered were viscosity and turbulence of Coanda jets, circulation control airfoils, airfoil theory, circulation control airfoil and wing experiments, circulation control rotor theory, X-Wing technology, and fixed-wing technology. The unclassified papers of the Workshop are reviewed in this paper, and Workshop recommendations for future research and development on circulation control are presented.
Surgical Pathology of Epilepsy: A Review (1994)

This review discusses the neuropathological issues pertaining to temporal lobectomies and neocortical resections for medically refractory seizures of childhood. Most cases in our pediatric series are "lesional" and have CT/MRI abnormalities that contribute to a higher incidence of "dual pathology" lesions rather than pure mesial temporal sclerosis. Almost up to two thirds of our cases are represented by neuronal migration disorders and low grade gliomas. We have also encountered lesions that have both neoplastic and malformative foci, some of which behave more like tumors, while others defy precise classification as tumor or malformation. Our preliminary data indicate a role for cytomegalovirus in some cases of Rasmussen's encephalitis.
Perspective: Machine learning potentials for atomistic simulations (2016)

Nowadays, computer simulations have become a standard tool in essentially all fields of chemistry, condensed matter physics, and materials science. In order to keep up with state-of-the-art experiments and the ever growing complexity of the investigated problems, there is a constantly increasing need for simulations of more realistic, i.e., larger, model systems with improved accuracy. In many cases, the availability of sufficiently efficient interatomic potentials providing reliable energies and forces has become a serious bottleneck for performing these simulations. To address this problem, currently a paradigm change is taking place in the development of interatomic potentials. Since the early days of computer simulations simplified potentials have been derived using physical approximations whenever the direct application of electronic structure methods has been too demanding. Recent advances in machine learning (ML) now offer an alternative approach for the representation of potential-energy surfaces by fitting large data sets from electronic structure calculations. In this perspective, the central ideas underlying these ML potentials, solved problems and remaining challenges are reviewed along with a discussion of their current applicability and limitations.
Adjuvant effect of caffeine on acetylsalicylic acid anti‐nociception: Prostaglandin E2 synthesis determination in carrageenan‐induced peripheral inflammation in rat (2007)

In the present study, we report a synergistic interaction between acetylsalicylic acid (ASA) and caffeine (CAF) on the inhibition of nociception in a model of peripheral inflammation in rat; on the contrary no interaction have been found on anti-inflammatory effects and peripheral prostaglandin E2 (PGE-2) synthesis inhibition. Acute inflammation was induced by the subplantar injection of carrageenan into the right hind paw, and the effects of the drugs were evaluated from 0 to 5h. Nociception was assessed using the Randall & Selitto test, and the inflammatory response by plethismometry. Oral administration of ASA (10-400mg/kg) induced dose-related anti-nociceptive and anti-inflammatory effects. On the other hand, oral CAF administration (5-50mg/kg) did not show a dose-related inhibitory effect, neither on the inhibition of nociception nor on the inflammatory response. To analyze a possible interaction between both drugs a dose-response curve to ASA plus a fixed dose of CAF (5mg/kg) was obtained 3h after the injection of carrageenan, when the inflammatory pain peaked. A fixed dose of CAF was able to improve the anti-nociceptive, but not the anti-inflammatory, effects of ASA. We also assessed, by enzyme immunoassay, the effects of the combination on peripheral PGE-2 levels: CAF did not alter the inhibitory effect of ASA on PGE-2 synthesis. Our results corroborate the well-known clinical effects of combining ASA and CAF; on the other hand, we rule out that prostaglandin synthesis inhibition at peripheral sites would be the mechanism responsible of the adjuvant anti-nociceptive effect of CAF.
Technical feasibility and safety of an intraoperative head‐up display device during spine instrumentation (2016)

A wearable head-up display can benefit current neuronavigation systems, but larger, outcomes-based trials are needed. Higher processing speed would allow streaming of higher resolution images. Along with an enlarged display, these may significantly improve utilization of this technology. Copyright © 2016 John Wiley & Sons, Ltd.
The specialized agencies and the United Nations: the system in crisis (1988)

Journal Article The specialized agencies and the United Nations: the system in crisis Get access The specialized agencies and the United Nations: the system in crisis. By Douglas Williams. London: Hurst for David Davies Memorial Institute. 1987. 279pp. Index. £17.50. ISBN 1 850 65025 7. R. J. Vincent R. J. Vincent 1Nuffield College, Oxford Search for other works by this author on: Oxford Academic Google Scholar International Affairs, Volume 64, Issue 4, autumn 1988, Pages 652–653, https://doi.org/10.2307/2626053 Published: 01 October 1988
Documenting pattern use in Java programs (2003)

Design patterns are widely recognized as important software development methods. Their use as software understanding tools, though generally acknowledged, has been scarcely explored. Patterns are most useful in understanding software when they are well documented. Sometimes they are described separately from code as design comments. Nevertheless, they have a strong relationship with the source code and thus they should also be documented at the source level. Unfortunately, there is no agreement on how to document pattern use. This paper describes a structured approach to documenting pattern use in the Java language. Our solution is based on the standard Javadoc tool and is able to generate HTML documentation. The approach has been implemented and tested with software that uses patterns.
Transport of toxic dinoflagellates via ships' ballast water:bioeconomic risk assessment and efficacy of possible ballast water management strategies (1998)

The results of 10 yr of Australian research efforts on transport of toxic dinoflagellate cysts via ships' ballast water are reviewed, supplemented with the conclusions of similar studies now underway in Europe, Israel, North America, Canada, Japan, China and New Zealand Toxic dinoflagellates are probably the best studied model organism to assess the bioeconomic risks of ballast water introduction of nonindigenous marine pests. A plausible scenario for their successful introduction and establishment in Australian waters is: (1) ballast water ~n t a k e during seasonal plankton blooms and to a lesser extent via resuspended cysts in sedimcmts from Japanese or Korean ports; (2) survival as resistant resting cysts durlng the ballasting proccss, the voyage in a dark ballast tank, and subsequent ballast water discharge (inoculation); (3) successful germination of cysts, sustained growth and reproduction of plankton cells in an Australian port; and (4) further spreading via coastal currents or domestic shipping, culminating under suitable environmental conditions in harmful algal blooms impacting on aquacultural operations (causative organisms of paralytic shellfish poisoning). Until international agreement and acceptance of a fully effective, practicable, safe, economically viable and environmentally friendly ballast water treatment is achieved (mid-ocean ballast water exchange and heat treatment are the only options offering promise at present), an international warning network for algal blooms in ports appears to be an effective way to minimise risks. It is also recommended that aquaculture operations and marine parks should be sited well clear of the ballast water influence of shipping ports.
Slow Wave Structures (1999)

Abstract The sections in this article are Guided Waves and Waveguides Fundamentals of Slow‐Wave Structures A Brief History of Slow‐Wave Development Basic Theory of Slow‐Wave Structure (ω − β) Dispersion Diagram and Slow‐Wave Parameters Approximate and Quasi‐Static Models Accurate and Hybrid‐Mode Field Models Slow‐Wave Summary and Applications
Procedures in Nucleic Acid Research. (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProcedures in Nucleic Acid Research.Waldo E. CohnCite this: J. Am. Chem. Soc. 1967, 89, 9, 2242Publication Date (Print):April 1, 1967Publication History Published online1 May 2002Published inissue 1 April 1967https://pubs.acs.org/doi/10.1021/ja00985a054https://doi.org/10.1021/ja00985a054research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The ligninolytic system of the white rot fungus Pycnoporus cinnabarinus: purification and characterization of the laccase (1996)

The white rot fungus Pycnoporus cinnabarinus was characterized with respect to its set of extracellular phenoloxidases. Laccase was produced as the predominant extracellular phenoloxidase in conjunction with low amounts of an unusual peroxidase. Neither lignin peroxidase nor manganese peroxidase was detected. Laccase was produced constitutively during primary metabolism. Addition of the most effective inducer, 2,5-xylidine, enhanced laccase production ninefold without altering the isoenzyme pattern of the enzyme. Laccase purified to apparent homogeneity was a single polypeptide having a molecular mass of approximately 81,000 Da, as determined by calibrated gel filtration chromatography, and a carbohydrate content of 9%. The enzyme displayed an unusual behavior on isoelectric focusing gels; the activity was split into one major band (pI, 3.7) and several minor bands of decreasing intensity which appeared at regular, closely spaced intervals toward the alkaline end of the gel. Repeated electrophoresis of the major band under identical conditions produced the same pattern, suggesting that the laccase was secreted as a single acidic isoform with a pI of about 3.7 and that the multiband pattern was an artifact produced by electrophoresis. This appeared to be confirmed by N-terminal amino acid sequencing of the purified enzyme, which yielded a single sequence for the first 21 residues. Spectroscopic analysis indicated a typical laccase active site in the P. cinnabarinus enzyme since all three typical Cu(II)-type centers were identified. Substrate specificity and inhibitor studies also indicated the enzyme to be a typical fungal laccase. The N-terminal amino acid sequence of the P. cinnabarinus laccase showed close homology to the N-terminal sequences determined for laccases from Trametes versicolor, Coriolus hirsutus, and an unidentified basidiomycete, PM1. The principal features of the P. cinnabarinus enzyme system, a single predominant laccase and a lack of lignin- or manganese-type peroxidase, make this organism an interesting model for further studies of possible alternative pathways of lignin degradation by white rot fungi.
Oxidized lipoproteins and nitric oxide (1996)

Nitric oxide has an important biological role as endothelium-derived relaxing factor, a key agent in the maintenance of normal vascular tone. It can also suppress lipoprotein oxidation, a potential anti-atherogenic property. However, in arteries subject to hypercholesterolemia or atherosclerosis, whereas nitric oxide synthesis is normal its biological activity is attenuated. This may be caused by its inactivation in the intima by components of oxidized lipoproteins acting both directly (by reaction with nitric oxide) and indirectly (by simulation of release of nitric oxide scavengers). Thus in hypercholesterolemia the normal balance between nitric oxide availability and lipoprotein oxidation is shifted to favour a self-reinforcing cycle of nitric oxide depletion and accelerated lipoprotein oxidation that may ultimately lead to atherosclerosis.
サッカー欧州選手権半世紀選手名鑑 : Euro 2008-1960 (2008)

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‘HANDEL'S TRAVELS IN THE NETHERLANDS IN 1750’ (1992)

‘HANDEL'S TRAVELS IN THE NETHERLANDS IN 1750’ Get access RICHARD G. KING RICHARD G. KING P.O. Box 9624, Stanford, California 94309, USA Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume 73, Issue 1, February 1992, Pages 173-a–173, https://doi.org/10.1093/ml/73.1.173-a Published: 01 February 1992
Imaging the liver (1995)

Jenny Kennedy gives a detailed account of the process and benefits of intra-operative ultrasonography
Reactivity and pH dependence of thiol conjugation to N-ethylmaleimide: detection of a conformational change in chalcone isomerase (1990)

The reactivity of simple alkyl thiolates with N-ethylmaleimide (NEM) follows the Brønsted equation, log kS- = log G + beta pK, with G = 790 M-1 min-1 and beta = 0.43. The rate constant for the reaction of the thiolate of 2-mercaptoethanol with NEM is 10(7) M-1 min-1, whereas the rate constant for the reaction of the protonated thiol is less than 0.0002 M-1 min-1. The intrinsic reactivity of the protonated thiol (SH) is over (5 X 10(10]-fold less than the thiolate (S-) and makes a negligible contribution to the reactivity of thiols toward NEM. The rate of NEM modification of chalcone isomerase was conveniently measured by following the concomitant loss in enzymatic activity. The pseudo-first-order rate constants for inactivation show a linear dependence on the concentration of NEM up to 200 mM and yield no evidence for noncovalent binding of NEM to the enzyme. Evidence is presented demonstrating that the modification of chalcone isomerase by NEM is limited to a single cysteine residue over a wide range of pH. Kinetic protection against inactivation and modification by NEM is provided by competitive inhibitors and supports the assignment of this cysteine residue to be at or near the active site of chalcone isomerase. The pH dependence of inactivation of the enzyme by NEM indicates a pK of 9.2 for the cysteine residue in chalcone isomerase. At high pH, the enzymatic thiolate is only (3 X 10(-5))-fold as reactive as a low molecular weight alkyl thiolate of the same pK, suggesting a large steric inhibition of reaction on the enzyme.(ABSTRACT TRUNCATED AT 250 WORDS)
Classified vector quantization of images using texture analysis (2002)

A new VQ-based image coding method, classified vector quantization using texture analysis (CVQ-TA) is proposed. The most notable differences between CVQ-TA and CVQ are: (1) the classification in CVQ-TA operates in the transform domain by means of texture analysis, and (2) product-code vector quantization is used to reduce the complexity increasing with the subblock size. Because of these characteristics, CVQ-TA can be applied for large block size (8*8 or 16*16), which is more efficient for block coding. Simulation results show that CVQ-TA can give a good visual perceptual quality.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>