gebhart/patrepeval huggingface dataset:
Acute and chronic effects of psychoactive drugs on adrenergic receptors and calmodulin. (1980)

The effects that psychoactive compounds have on those biochemical mechanisms of brain that influence the metabolism of cyclic nucleotides depend on whether the drugs are administered acutely or chronically. For example, antipsychotic agents acutely block the action of catecholamines on the adrenergic receptor-adenylate cyclase complex, thereby preventing the catecholamine-induced rise in cyclic AMP. But with long-term treatment, which might correspond more closely to the manner in which they are used clinically, the drugs appear to produce a compensatory increase in these catecholaminergic receptors. Repeated stimulation of adrenergic receptors with compounds that block the uptake of catecholamines, such as the antidepressants, produces a decrease in the number of these receptors and a concomitant subsensitivity to the effects of catecholamines on the formation of cyclic AMP. This is in contrast to their acute actions which result in a potentiation of the action of catecholamines. In addition to their effects on catecholamine receptors, clinically-effective antipsychotic drugs also bind to an endogenous calcium-dependent protein termed calmodulin, which is found in high concentrations in the CNS. This binding of antipsychotics to calmodulin can explain several of their biochemical actions and suggests that some of the pharmacological and perhaps clinical effects of these drugs may also be explained by a common mechanism. In fact, the specificity with which antipsychotic drugs bind to calmodulin suggests the possibility of searching for new and clinically more effective antipsychotic agents based on their selective binding to calmodulin.
Chiral separation of <i>rac</i>‐Ornidazole and detection of the impurity of (<i>R</i>)‐Ornidazole in (<i>S</i>)‐Ornidazole injection and raw material (2006)

(S)-Ornidazole is a subject of research as an antifertility agent in male animals at present. However, there seems to be no relative report on chiral separation for rac-Ornidazole, which has been used as an effective medicine for more than 30 years. In this article, the chiral separation of rac-Ornidazole on a Chiralcel OB-H column based on normal-phase high-performance liquid chromatography (NP-HPLC) is investigated and the methodology for detection of impurity of (R)-Ornidazole in (S)-Ornidazole injection and raw material is established. The novel mobile phase is utilized by mixing n-hexane, methanol and isopropyl alcohol (95:4:1, v/v/v) instead of the typical mobile phase of n-hexane and isopropyl alcohol, although the methanol, which offers a good resolution factor for the enantiomeric separation in this system, is not recommended on the Chiralcel OB-H column according to the instruction supplied by Daicel Chemical Ind., LTD (Japan).
Operation of dual gate MOS field effect transistors at 77 K and use in rf and video amplifiers (1971)

Measurements have been made with dual gate MOS field effect transistors when immersed in liquid nitrogen. It has been found that such devices are suitable for wideband and tuned rf amplifiers, with improved characteristics. Simple practical amplifier circuits and their characteristics are described.
ANTIREFLUX SURGERY IN SPECIAL PRESENTATIONS OF PATIENTS (2020)

Gastro-esophageal reflux disease (GERD) was defined according to the Montreal consensus as “a condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications”. A recent randomized-controlled trial showed that laparo­scopic Nissen fundoplication was superior to medication in reduc­ing reflux-related heartburn.

Antireflux surgery represented by Nissen fundoplication is a valuable solution in typical GERD cases. For patients presented with one of the different presentations; like failed previous fundoplication, Non-Erosive Reflux Disease (NERD), Barrett’s dysplasia, and esophageal dysmotility, a complete or partial wrap should be cautiously decided.
Isolation of a 7S particle from Xenopus laevis oocytes: a 5S RNA-protein complex. (1979)

Previtellogenic oocytes of Xenopus laevis contain a free 5S RNA-protein complex sedimentating at 7 S. This particle consists of one molecule of 5S RNA and one 45,000-dalton protein. The protein of the 7S particle and the protein that is released in association with 5S RNA when the ribosome is treated with EDTA are unrelated. Because the 5S RNA accumulated by small oocytes in storage particles is incorporated into the ribosome later in oogenesis, we conclude that 5S RNA is succesively associated with two proteins during the life span of the oocyte.
Keyhole Estimation of an MIMO-OFDM Train-to-Wayside Communication System on Subway Tunnels (2014)

This letter presents a deep insight on a real implementation of a train-to-wayside radio on subway tunnels that makes use of a 2 × 2 multiple-input-multiple-output orthogonal frequency-division multiplexing (MIMO-OFDM) setup. The main purpose of this letter is to study in detail the keyhole phenomenon of an MIMO-OFDM train-to-wayside communication system on a tunnel. MIMO keyholes are studied in different tunnels sections, and capacity results are provided. Moreover, we introduce the first keyhole measurements on a railway tunnel. Finally, we follow a quantitative approach to estimate keyhole probabilities on each tunnel stretch and capacity outage curves.
High resolution imaging for forward looking SAR with multiple receiving antennas (2002)

There are two most serious problems in the imaging mode of forward-looking SAR (F-SAR). The first one is that the gradient of the Doppler frequency is very small and it is very difficult to achieve high azimuth resolution. The second one is that the terrain targets situated symmetrically about the flight/moving path have the same Doppler history, which causes serious azimuth ambiguity. This paper will adopt an imaging configuration of F-SAR with multiple receiving antennas. The azimuth resolution and ambiguity problem is discussed for this kind of F-SAR. The contribution of multiple receiving antennas to the azimuth unambiguity and high resolution imaging result is analyzed.
Three-mode principal component analysis : theory and applications (1983)

Other publications in this series: Jacqueline Meulman, Homogeneity analysis of incomplete data. M &amp; T series 1, 1982 Pieter M. Kroonenberg, Tree-mode principle component analysis.
LNG production on marine structures with clarification of motion influence on absorption and rectification (1983)

A large number of concepts for the treatment and liquefaction of natural gas above offshore sources have been proposed. Various process units were considered to require extensive testing prior to commercial application. Motion influence of seaborne structures on the functioning of several gas processing plant components has until recently not been clarified, e.g., the performance of absorption and rectification towers on floating platforms was uncertain. Based on large-scale tests with 2 column types, the reaction of separation processes under marine conditions is predicted. These investigations demonstrate the influence of irregular motion in all 6 of freedom on a closed rectification process. The test unit--a modified tray type and a packed column--was installed on a motion simulator, which generated motion according to platform response characteristics and sea spectra. Results show that the motion effect has to be taken into consideration.
Stem cell factor protects bone marrow‐derived cultured mast cells (BMCMC) from cytocidal effect of nitric oxide secrected by fibroblasts in murine BMCMC‐fibroblasts coculture (1996)

The survival of mast cells are dependent on two kinds of growth factors, one derived from T cells (IL-3) and another derived from fibroblasts (stem cell factor [SCF]). The 3T3 fibroblast cell line derived from WCB6F(1-)+/+ mouse embryos (+/+ 3T3 fibroblasts) supported the proliferation of bone marrow-derived cultured mast cells (BMCMC) in the PWM-stimulated spleen cell conditioned medium (PWM-SCM), whereas the 3T3 fibroblast cell line from WCB6F1-Sl/Sld mouse embryos (Sl/Sld 3T3 fibroblasts) did not. To study the role of nitric oxide (NO) on the growth of mast cells in BMCMC-fibroblast coculture, we used a NO synthase inhibitor, NG-monomethyl-L-arginine (NGMMA). NGMMA recovered survival and maintained proliferation of mast cells in BMCMC-Sl/Sld 3T3 fibroblasts coculture. Sl/Sld 3T3 fibroblasts as well as 3T3 fibroblasts from NIH(-)+/+, BALB(-)+/+ or Swiss(-)+/+ mouse embryos secreted NO in PWM-SCM, but not in alpha-MEM. SCF protected BMCMC from cytotoxicity of exogenous NO in IL-3-supplemented alpha-MEM. We concluded that SCF might protect BMCMC from cytocidal effect of NO in BMCMC-fibroblasts coculture.
Capacity enhancement and Performance evaluation in 4G LTE-Advanced networks using Sectored Relaying (2016)

Cell interference and coverage shortage of base stations result in low Signal to Interference plus Noise Ratio (SINR) and poor spectral efficiency. To overcome these problems in 4G LTE-Advanced networks â€“ A new method of capacity enhancement and performance evaluation using Sectored Relaying is proposed in this paper. The main focus is laid on the selection of the location for the relay node (RN) in the cellular network so that Access Link attains much improved performance in terms of throughput capacity and Signal to Interference plus Noise Ratio (SINR) besides improving the quality of wireless relay backhaul link. A mathematical model of the proposed system in terms of throughput capacity, path loss attenuation and Access Link SINR has been developed. The Mathematical Modeling of the proposed system has been verified by the simulations carried on Matlab 14. A significant improvement has been observed from the results, which justify the need for sectored relaying in relay enhanced networks. The parameters for simulation have been used in accordance with 4G LTE standard. Moreover, it has been observed that the proposed technique has lesser complexity with minimal deployment expenditure and performs better than the existing techniques.
An Optimization System Applied in Optical Design of LED Light GuidePlate (2013)

Most of the small and medium-sized backlight modules are applied to a small amount of various products. Since the time to design a product is rigid and the light guide plate (LGP) is the key component that affects the quality of backlight modules, photovoltaic industries can enhance the core competence if they are able to develop high standard light guide plates with fast and efficient methods. The study proposes an optical optimal design system of light guide plate (LGP). The optimization design is conducted in the longitudinal structure of the LGP incidence plane with three LED light sources. Taguchi method is also used in carrying out the design of experiment through the TracePro, optical analysis software, and the experiment data which are employed as the back-propagation neural network (BPNN) training and testing samples and, then, created an optical quality predictor of the longitudinal structure. BPNN can predict the impact of incidence plane luminance versus the different constructed parameters. Finally, the optical quality predictor can effectively generate the optimal parameters settings combined with genetic algorithm (GA). The simulation results show that the proposed system can improve the non-uniformity problem of the incidence plane but also make it easier to design the longitudinal structure of the incidence plane.
Geomorphological analysis and prioritization of sub-watersheds using Snyder’s synthetic unit hydrograph method (2014)

The present study makes an attempt to prioritize sub-watersheds based on Snyder’s synthetic unit hydrograph method. Snyder’s method of synthetic unit hydrograph calculates peak discharge and lag time of the unit hydrograph for each sub-watersheds. Compound values of ranking are calculated from assigned rankings to parameters, viz. peak discharge and lag time. Depending on the range of the compound values sub-watersheds are classified as high, medium and low soil-erosive sub-watersheds. The priorities obtained from Snyder’s synthetic unit hydrograph method are compared with the methods of morphometric analysis and land use/land cover analysis. On comparison of priorities for Dangri River watershed, Panchkula District, Haryana (India), among the three methods it was found that the sub-watershed (SW1) has the same priority. Among all the three methods, Snyder’s synthetic unit hydrograph is a better method, as it is easier to use and less data intensive.
Structure of heparan sulphate oligosaccharides and their degradation by exo-enzymes (1979)

Oligosaccharides obtained from heparan sulphate by nitrous acid degradation were shown to be degraded sequentially by beta-D-glucuronidase or alpha-L-iduronidase followed by alpha D-N-acetylglucosaminidase. Structural analysis of the tetrasaccharide fraction showed the following. (1) N-Acetylglucosamine is preceded by a non-sulphated uronic acid residue that can be either D-glucuronic of L-iduronic acid, but followed by a glucuronic acid residue. (2) The N-acetylglucosamine in the major fraction is sulphated. (3) Very few if any of the uronic acid residues are sulphated (4). The results indicate that the area of the heparan sulphate chain where disaccharides containing N-acetylglucosamine and N-sulphated glucosamine residues alternate is higher in sulphate content than expected and that the sulphate groups are mainly located on the hexosamine units.
Automatic Discovery Techniques for T-MPLS Packet Transport Network (2012)

T-MPLS is a connection-oriented packet switched solution for the next generation transport networks. The concept was first proposed by ITU-T in Geneva, Feb 2006. The standardization process is pushed by ITU-T and IETF, many recommendations appeared recently. T-MPLS is much easier to achieve a convergent packet platform for any L2 protocol. It focuses on the packet transport applications that adhere to the standard groups. The OAM, protection and switch function and network management aspects are nearly finished by now but the control plane standardizations have not obtain a common senses about how this technologies evolve in future. In this paper, we compared the automatic discovery requirement in T-MPLS with other discovery techniques used in other network, such as in IP, RPR, Ethernet, ASON, etc. The detail mechanism and protocol in other network are described respectively. As for the intelligent networks, the discovery procedure is done by the control plane due to its responsibilities. Maybe we can use the discovery tools such as SNMP, ARP, ICMP, OSPF, the coordination between the control plane and the discovery process is necessary. Simulation model is also designed in OPNET modular 11.5 to compare these approaches.
High Performance Liquid Chromatography of Cholesteryl Esters (1991)

Abstract The separation of cholesteryl esters by high performance liquid chromatography was facilitated by cooling of the column, followed by spontaneous return to ambient conditions. the resolution of the esters was increased. the method was applied to detection of the cholesteryl esters in plasma.
Structural characterization of Mo/Ru/Si EUV reflector by optical modeling (2004)

The performance of multilayer extreme ultraviolet (EUV) reflector has direct bearing on the process throughput and cost of new technology. Using measured data from the experimentally manufactured reflector, we intended, in this work, to show that the reflectivity of the Bragg reflector can be characterized by structural parameters such as d-spacing, density, and the thickness of inter-diffusion layers and oxidation layer. This quantitative analysis of the reflectivity derived from the structural parameters can be utilized to optimize the optical properties of the existing Mo/Ru/Si system as well as to provide fundamental insights into the science involved in a Bragg EUV reflector.
Robert Barany and the controversy surrounding his discovery of the caloric reaction (2002)

It was not until the latter half of the 19th century that the vestibular part of the inner ear was recognized to have a function separate from hearing. Robert Bárány was one of the first clinicians to assess vestibular function systematically in patients. He developed standard caloric, rotational, and pointing tests and was the first to describe benign paroxysmal positional nystagmus. Bárány began his career working in the otology clinic of Adam Politzer at the University of Vienna. He received the Nobel Prize in Medicine in 1916 for his work on the mechanism of the caloric reaction. However, in the aftermath of the First World War and the controversy surrounding his selection for the Nobel Prize, Bárány left Vienna for Uppsala, Sweden, where he spent the last 20 years of his life in relative isolation.
How effective and valued are nurse consultants in the UK? (2004)

The introduction of nurse consultant posts has heralded a dramatic change in nursing. Many factors have influenced this change. Documents such as the UKCC's the Scope of Professional Practice (UKCC 1992a), and NHS reforms are among them. The aim of this article is to explore the effectiveness of nurse consultants.
Chronic obstructive pulmonary disease and venous thromboembolism recurrents : A prospective study (2016)

<b>Introduction:</b> Chronic Obstructive Pulmonary disease (COPD) is an inflammatory disease associated with prothrombotic abnomalities. The main objective of the study was to evaluate the risk of recurrent venous thromboembolism (VTE) in patients with a first VTE and COPD. <b>Methods:</b> Of the 1948 patients included, 423 had recurrent VTE (45 patients with COPD and 378 without COPD) during a median follow-up period of 2.4 years. The annual incidence rate of recurrent VTE was 9.2% (95% CI 6.9-12.3) for COPD patients and 5.1 % (95% CI 4.6-5.6) for non COPD patients. COPD was not associated with an increased VTE recurrence risk on multivariate analysis (hazard ratio: 1.2 95% CI 0.9-1.6 p=0.29). In COPD patients, recurrent VTE occurred more often as PE than DVT. The risk of death, adjusted on demographic and clinical characteristics was not increased in COPD patients as compared to non COPD patients. <b>Results:</b> The EDITH study is prospective cohort of 1948 patients with a first VTE recruited between 2001 and 2014. COPD was confirmed by spirometry in 139 patients. The main outcome was documented and adjudicated recurrent VTE after stopping anticoagulation, defined by symptomatic deep vein thrombosis (DVT), non fatal pulmonary embolism (PE) or fatal PE. Secondary outcome was overall mortality. Univariate (using a Log Rank test) and multivariate (using a Cox model) analyses were used to identify risk factors of recurrence. <b>Conclusion:</b> In patients with COPD who had a first episode of VTE, the risks of recurrent VTE and death were not found to be higher than that in non COPD patients. However, recurrences occurred more often as PE rather than DVT in COPD patients.
Text Classification via Sentence-level Graph Convolutional Networks (2019)

텍스트 분류는 자연어처리 분야의 전통적인 문제이다. 기존의 RNN 및 CNN 기반 텍스트 분류 모델들은 순차적인 단어 구조에 의존하기 때문에 인접하지 않지만 관련성이 높은 단어 간의 관계를 유추하기 어렵다는 문제점이 있다. 반면 GCN(Graph Convolutional Network)은 그래프의 형태로 데이터를 입력받기 때문에 문장의 순차적 구조에 대한 의존도를 줄일 수 있다. 본 논문에서는 문서의 비순차적인 관계를 그래프로 담아내어 더욱 효과적으로 파악하고 분류하는 인공신경망 모델을 제안한다. 문서를 그래프로 표현하기 위해 각 단어를 그래프의 노드로 변환하고, 단어 간의 관계를 계산해 엣지로 정의한다. 최근에 제시된 GCN 구조를 통해 단어 간의 관계가 반영된 단어 벡터를 계산한 뒤, 어텐션 기반 요약 함수를 통해 문단을 주어진 클래스로 분류하는 방법을 제시한다. 실험 결과, 새롭게 제시된 모델이 RNN 및 CNN 기반 텍스트 분류 모델보다 좋은 성능을 보였다.
Treatment of Carcinoma of the Oral Cavity (1970)

The treatment experience in 173 cases of carcinoma of the oral cavity was analyzed. Radical irradiation followed by surgery for failure or a planned combination of preoperative irradiation and radical surgery constituted the treatment plan. Lesions of the anterior pillar appear to benefit from the planned combination of irradiation and surgery, while other lesions of the oral cavity, especially floor of mouth, can be effectively managed by primary radical irradiation with adjunctive surgery for failure. No increase in morbidity was noted in the combined cases even when surgery was utilized for failure at a comparatively long interval after irradiation.
Constrained Delaunay triangulation for multiresolution surface description (2003)

The problem of building a constrained Delaunay triangulation (CDT) at different levels of resolution is considered for the hierarchical description of topographic surfaces. The surface is approximated at each level by a network of planar triangular faces having vertices at a subset of surface-specific points, such as peaks, pits, or passes, and including edges that describe surface-specific lines, such as ridges or valleys. Each approximation is built based on a Delaunay triangulation of the data points that includes the given constraint segments. A dynamic algorithm for constrained Delaunay triangulation is proposed. The algorithm is based on the stepwise refinement of a CDT by the incremental insertion of points and constraint segments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Automated software engineering through structured data management (1976)

The Software Engineering Facility (SEF) is a system for software engineering which is specifically designed to support the development of well-engineered software. However, it is not an operating system. Unlike operating systems such as OS/370, EXEC 8, and others, the SEF is not meant to support the execution of applications programs, just as the ordinary operating systems are not intended to specifically support the development of well-engineered applications programs. The SEF, in fact, will run under and use the facilities of such operating systems. It, then, is easily transferable and can be used with various hardware/operating system configurations where it will provide a host-independent software development system. In such a role it will provide to the software developer standard facilities across a variety of host systems.The SEF provides the central support for an integrated collection of subsystems, and the subsystems provide appropriate facilities for all phases of the software development process, from requirements definition through maintenance and enhancement. Each such subsystem contributes in a cohesive way towards the cost-effective development of well-engineered software.The design of the SEF was determined only after a careful analysis of the software development process and a thorough study of recent efforts in the field of software engineering.