gebhart/patrepeval huggingface dataset:
miR-181a involves in the hippocampus-dependent memory formation via targeting PRKAA1 (2017)

Post-transcriptional gene regulation by microRNAs (miRNAs) is involved in memory formation. However, the roles of individual miRNAs in these processes remain largely unknown. In this study, we want to clarify the role of miR-181a in hippocampus-dependent memory formation. A transient increase in miR-181a expression was observed after conditioned fear conditioning (CFC) and object location task (OLT) training. Selective overexpression or inhibition of miR-181a in the dorsal hippocampus (DH) via the injection of a miR-181a agomir or antagomir enhanced or impaired the CFC- and OLT-dependent memory formation, respectively. Using bioinformatics and luciferase assays, we identified PRKAA1 as a potential target gene of miR-181a. After CFC or OLT training, the expression and activity of PRKAA1 decreased as miR-181a expression increased and was effectively blocked by the miR-181a antagomir. Moreover, microinjection of the PRKAA1 agonist AICAR or inhibitor compound C in the DH reversed the roles of the miR-181a agomir or antagomir in CFC- and OLT-dependent memory formation. In conclusion, this work provides novel evidence describing the role and mechanism of miR-181a in hippocampus-dependent memory formation, which sheds light on the potential regulation of cognition and future treatments for cognitive disorders.
Preparation and Characterization of Collagen–Hydroxyapatite Composite Used for Bone Tissue Engineering Scaffold (2003)

In this study, highly porous collagen-HA scaffolds were prepared by solid-liquid phase separation method. Microstructure of the composites was characterized by SEM, TEM and XRD. The results show that collagen-HA scaffolds are porous with three-dimension interconnected fiber microstructure, pore sizes are 50-150 microm, and HA particles are dispersed evenly among collagen fiber. Compared with pure collagen, the mechanical property of collagen-HA composite improves significantly. To gain further insight into cell growth throughout 3D scaffolds, the cell proliferation and attachment on the scaffold in vitro was investigated. The collagen-HA composite has good biocompatibility, and adding HA does not affect the histocompatibility of the scaffold materials. The porous collagen-HA composite is suitable as scaffold used for bone tissue engineering.
In Vitro Complement Consumption by Contrast Materials and Analogues (1983)

Blood samples from previous contrast reactors and nonreactor controls were incubated with diatrizoate and several contrast analogues. Total complement levels were assayed. All the agents caused complement activation generally proportional to their concentration. Reactors' sera responded to lower concentrations of contrast or analogues than did control sera. Such studies might be of value in predicting contrast reactors.
A Study on a New Method of Measurement of Pore Volume Distribution in Porous Materials by Adsorption of Gases (1987)

A new method of measurement of pore volume distribution in a porous material by adsorption of gases is proposed. In the newly proposed method the use of spherical molecules with relatively large molecular weight as adsorbates is strongly recommended to eliminate the troubles caused by stereospecificity and low boiling point of widely used . It is also claimed that the universal t-curves that have been widely used since proposed by de Boer et al. must be replaced by the flat-surface isotherms that can be derived from the theory proposed by Chang et al. The results of analysis of pore volume distribution based on the method described in this paper are found to be reasonable and satisfactory.
Approaches to static background identification and removal (1993)

A common feature of many image processing applications is the classification of the data into regions of interest, often called the foreground, and unwanted regions referred to as being the background. An example of this process is the extraction of the steady-state component from a video sequence. Subtraction of this static component yields images containing only the desired foreground data. This is a common operation in real-time image processing performed within widely varying applications. As image processing develops, both in complexity and application, the role of background extraction algorithms in the pre-processing of raw data is increasing. The reasons for using these techniques can be categorised loosely into three key areas: bandwidth reduction, cost, and complexity reduction. >
Notes - N-Vinyl-2-Oxazolidone (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - N-Vinyl-2-OxazolidoneErhart DrechselCite this: J. Org. Chem. 1957, 22, 7, 849–851Publication Date (Print):July 1, 1957Publication History Published online22 April 2003Published inissue 1 July 1957https://pubs.acs.org/doi/10.1021/jo01358a621https://doi.org/10.1021/jo01358a621research-articleACS PublicationsRequest reuse permissionsArticle Views223Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Iniciativa de pesquisa no ciberespazo lusófono Rede para a detección de barreiras na circulación de produtos do audiovisual galego (2012)

A aplicacion das novas tecnoloxias e do concepto “rede virtual” como sustento do proceso investigador, presentase como piar basico do proxecto Lusofonia: interactividade e interculturalidade do Grupo de Estudos Audiovisuais da USC. Este proxecto, ao abeiro do programa In.ci.te de I+D, pretende localizar, a partir do estudo da recepcion de produtos-modelo, as barreiras linguisticas, culturais ou politicas que frean a circulacion de produtos audiovisuais en lingua galega no espazo lusofono. Tanto a formulacion inicial como a metodoloxia de traballo e mesmo a obtencion de resultados artellanse de acordo coa aplicacion das tecnoloxias da Sociedade da Informacion ao conxunto do proceso. Crease, pois, unha intranet de xestion especifica de xeito que, tanto as relacions dos membros do equipo de investigacion, como as destes cos grupos parceiros e cos universos de recepcion da pesquisa, conformasen unha rede de intercambio que tivese como marco de desenvolvemento o ciberespazo lusofono.
Fuzzy <formula formulatype="inline"><tex Notation="TeX">$n$</tex></formula>-Ellipsoid Numbers and Representations of Uncertain Multichannel Digital Information (2013)

In this paper, we present the definition of fuzzy n-ellipsoid numbers that are a special kind n-dimensional fuzzy numbers which are not only more objective and more rational in expressing uncertain multichannel digital information than are fuzzy n-cell numbers but keep the convenience being used in applications and researches of the theory as well. We also obtain two representation results. Then, for the sake of the application of fuzzy n-ellipsoid numbers, we define some special kinds of fuzzy n-ellipsoid numbers, investigate their properties, set up a specific iterative algorithm of their membership function value, and prove the convergence of the iterative algorithm. And then, we establish an algorithmic version of constructing fuzzy n-ellipsoid numbers to express an object that is characterized by a group of uncertain multichannel digital information, as well as give practical examples to show the application and rationality of the proposed techniques.
The Effects of Atorvastatin on Hematological and Inflammatory Parameters. (2008)

Abstract Background: Chronic inflammation may play role in the development of atherosclerosis and its complications. In hypercholesterolemia, the evidences of chronic inflammation such as the stimulation of chemokines and cytokines, increase in endothelial adhesion molecules, and the immune reactions against oxidants on lipoproteins are detected. It was shown that statins had some beneficial effects on lipids, thrombosis, endothelial dysfunction, and smooth muscle proliferation. Aim: To investigate the effects of atorvastatin on hematological and inflammatory parameters in prospective study. Material and methods: Forty patients (14 male and 26 female) with primary hypercholesterolemia were treated with 20 mg/day atorvastatin for 12 weeks, according to Adult Treatment Panel for Third Report of National Cholesterol Education Program. All patients received a detailed description of this study and signed consent prior to enrollment. National and local ethical committees approved this study. The exclusion criteria were secondary hypercholesterolemia, acute coronary syndromes, liver and renal dysfunctions, diabetes mellitus, acute/chronic infection and inflammatory diseases, pregnancy, lactation, malignancy, and tendency to bleeding. At baseline, and 12th weeks, lipid levels such as low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), very-low-density lipoprotein cholesterol (VLDL-C), triglycerides (TGs), and hematological parameters such as whole blood cell counts, hemoglobin and fibrinogen levels, CD3, CD4, CD5, CD8, CD14, CD16, CD19, CD40, CD45 using flow-cytometry, inflammatory parameters such as interleukin-1 (IL-1), IL-6, IL-18, tumor necrosis factor-alpha (TNF-a), interferon-gamma, soluble CD-40, intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1, high-sensitive CRP, sedimentation rate, and enzymes including CK, AST, ALT were evaluated. The results were compared with two-paired student’s-t test. Results: At the end of study, atorvastatin decreased TC (p&lt;0.001), LDL-C (p&lt;0.001), TGs (p=0.006), VLDL-C (p=0.012), and HDL-C (p&lt;0.001). While absolute lymphocyte (p=0.003) and platelet counts (p=0.001) were decreased with atorvastatin treatment, absolute monocyte count increased (p=0.002). On flow-cytometric examination, the expressions of CD14 (p=0.015) and CD19 (p=0.039) on lymphocytes were decreased with atorvastatin. Moreover, atorvastatin decreased the levels of TNF-a (p&lt;0.001), sCD40 (p&lt;0.001), ICAM-1 (p&lt;0.001), and IL-18 (p=0.024). ALT increased at the end of treatment (p=0.041). But important adverse events were not seen in the patients. Conclusion: The anti-platelet and anti-inflammatory effects of atorvastatin, independent from lipid-lowering effects, may play an important role on the prevention of atherosclerosis, in addition to its beneficial effects on lipid parameters.
Reducing test application time by scan flip-flops sharing (2000)

The test application time is reduced while preserving the test quality or the fault coverage for circuit testing. The goal is achieved by reducing the number of scan flip-flops required for a scan-based design, and the basic procedure is to look for groups of ``s-independent inputs.'' The s-independent inputs in a group have the property that, when these inputs are combined together to share a scan flip-flop, the originally detectable faults are still detectable under the new scan structure. Though the number of test vectors may slightly increase, this can be offset by the significant reduction in the scan test width. Thus, the goal of test time reduction for scan test can be accomplished. For circuits which have few s-independent inputs, bypass storage cells are added to increase the s-independencies among all inputs. Experiments have been performed on MCNC benchmarks and the results are good. Several benchmark circuits have shown more than 90% of test time reduction.
Efeitos da suplementação de ácido linoleico conjugado (CLA) e a perda de peso em animais e humanos (2007)

Americanae nace como un proyecto conjunto que surge dentro de la Red Europea de Información y Documentación sobre América Latina (REDIAL), y que ha afrontado la Biblioteca de la Agencia Española de Cooperación Internacional para el Desarrollo (AECID). Esta nueva biblioteca virtual hace más accesibles los libros digitales de tema americanista a los investigadores y usuarios interesados de cualquier parte del mundo.
[The importance of ano-rectal manometry in irritable bowel syndrome]. (2002)

Anorectal manometry could be a useful tool for the evaluation of IBS patients.
Electrophysiological and Structural Remodeling in Heart Failure Modulate Arrhythmogenesis. 1D Simulation Study (2014)

An extensive literature now establishes that in human ventricle, as heart failure progresses, gradients for repolarization are changed significantly by protein specific electrophysiological remodeling (either homogeneous or heterogeneous). Our simulations illustrate and provide new insights into this. Furthermore, enhanced fibrosis in failing hearts, as well as reduced intercellular coupling, combine to increase electrophysiological gradients and reduce electrical propagation. In combination these changes set the stage for arrhythmias.
Current, October 01, 1970 (1970)

https://irl.umsl.edu/current1970s/1017/thumbnail.jpg
Live Optical Imaging of Nervous System Development (2004)

Although development of the nervous system is inherently a process of dynamic change, until recently it has generally been investigated by inference from static images. However, advances in live optical imaging are now allowing direct observation of growth, synapse formation, and even incipient function in the developing nervous system, at length scales from molecules to cortical regions, and over timescales from milliseconds to months. In this review, we provide technical background and present examples of how these new methods, including confocal and two-photon microscopy, GFP-based markers, and functional indicators, are being applied to provide fresh insight into long-standing questions of neural development.
Semiconductor Diodes and Transistors as Electrical Thermometers (1962)

Electrical thermometers for laboratory experiments, environmental testing, and flight performance of rocket-borne equipment may be realized with simple semiconductor circuits. The devices described here utilize the variation with temperature of voltage across a forward-conducting p-n junction. This voltage variation of approximately 2 mv/°C is virtually linear over the entire test range of −40 to +100°C. A diode used in conjunction with a microammeter to measure the voltage across the diode is most convenient for laboratory use. For airborne use, where a signal varying from 0 to 5 v is required for telemetry, the transistor circuit is ideal. The latter circuit, which amplifies its own base-emitter junction voltage variations, requires only a single transistor and 3 resistors. Adjustment of two of the resistance values enables the user to select any temperature range to be covered with the desired sensitivity.
Visual tracking of small animals based on real-time Level Set Method with fast infra-red thermographic imaging (2011)

In this paper, we present a long-term monitoring of moving and high deformable objects with fast thermographic infrared imaging, in a process of developing an automated image analysis of laboratory animals' postures and activities. For this several days tracking, we tackle the object deformations with a model-based articulated body parts scheme and the two-stage tracking and segmentation technique is performed through a Kalman filtering associated to a level-set method. The latter is the main contribution of the paper (with also the contours classification of each body parts) since the proposed segmentation is robust to noise and heat places and can easily be parallelized and executed in real-time. Each body part is modelled with a set of geometrical descriptors with mutual interactions. The advantage of such method is not only to separate the dynamics of the whole object motion from those of body parts deformations but it also allows to extract apparent postural information to further produce a model of animal behaviour.
Solid-State Fault Current Limiting for DC Distribution Protection (2017)

This paper discusses solid-state fault current limiting technologies. Both solid-state fault current limiters and converters can quickly limit DC fault currents and permit other protective devices to perform appropriate fault interruption and/or isolation. Different system protection strategies using solid-state fault current limiters and converters are presented and analyzed. The advantages and disadvantages of different methods are also discussed and compared.
José M. Merino (2007)

Intensidad y precision en la novela ganadora del premio Torrente Ballester 2006, que narra la persecucion de los paraisos interiores mediante la huida de casi todo
On blind separation of convolutive mixtures of independent linear signals in unknown additive noise (1998)

Blind separation of independent signals (sources) from their linear convolutive mixtures is considered. The various signals are assumed to be linear non-Gaussian but not necessarily i.i.d. First, an iterative, normalized higher order cumulant maximization-based approach is exploited using the third- and/or fourth-order normalized cumulants of the "beamformed" data. It provides a decomposition of the given data at each sensor into its independent signal components. In a second approach, higher order cumulant matching is used to consistently estimate the MIMO impulse response via nonlinear optimization. In a third approach, higher order cumulants are augmented with correlations. For blind signal separation, the estimated channel is used to decompose the received signal at each sensor into its independent signal components via a Wiener filter. Two illustrative simulation examples are presented.
Schottky contact and the thermal stability of Ni on <i>n</i>-type GaN (1996)

The Schottky barrier height of Ni on n-GaN has been measured to be 0.56 and 0.66 eV by capacitance–voltage (C–V) and current–density–temperature (J–T) methods, respectively. Gallium nickel (Ga4Ni3) is formed as Ni is deposited on the GaN film, which affects the barrier height markedly. The thermal stability of Ni on GaN is also investigated by annealing these specimens at various temperatures. Specimen annealing at temperatures above 200 °C leads to the formation of nickel nitrides Ni3N and Ni4N at the interface of Ni and GaN. These interfacial compounds change the measured barrier height to 1.0 and 0.8 eV by C–V and J–T methods, respectively. Comparisons of Schottky characteristics of Ni with those of Pt, Pd, Au, and Ti are also discussed.
Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer. (2014)

The objective of the current study was to investigate the expression pattern and clinicopathological significance of Period1 (Per1), Period2 (Per2) and Period3 (Per3) in patients with non-small cell lung cancer (NSCLC). In 130 archived NSCLC tissues, the positive rate of Per1 (86/130, 66.2%), Per2 (77/130, 59.2%) and Per3 (82/130, 63.1%) were reduced in human lung cancer samples compared with adjacent normal lung tissues (Per1, 119/130, 91.5%; Per2, 115/130, 88.5%; Per3, 121/130, 93.1%), as measured by immunohistochemical staining. Loss of Per1 was correlated with poor differentiation (P < 0.001), tumor status (P=0.04), high p-TNM stage (P < 0.001) and lymph node metastasis (P=0.045). The similar tendencies were also found in the correlation of the expression of Per2 and Per3 with clinicopathological factors. In addition, a significant correlation was found between Per1 and Per2 (P < 0.001) in 130 cases of NSCLC. Similarly, a significant correlation was found between Per2 and Per3 (P=0.045). Patients with lower expression of Per1, Per2 and Per3 had a shorter survival time than those with higher expression. These results indicate that loss of Per may promote tumor progression in NSCLC, and may serve as a novel prognostic biomarker of NSCLC.
A new trap for singlet oxygen in aqueous solution (1979)

The sodium and caesium salts of anthracene-9,10-bisethanesulphonic acid are soluble in water, and readily react with singlet oxygen without appreciable quenching to give the stable endoperoxide; kinetic parameters are reported and it is shown that in the decomposition of peroxymonophthalic acid at pH 8·2, 69 ± 4% of the oxygen produced is in the singlet state.
Kinetics and Mechanism for Reduction of the Anticancer Prodrug <i>trans,trans,trans</i>-[PtCl<sub>2</sub>(OH)<sub>2</sub>(<i>c</i>-C<sub>6</sub>H<sub>11</sub>NH<sub>2</sub>)(NH<sub>3</sub>)] (JM335) by Thiols (2000)

The reduction of the platinum(IV) prodrug trans,trans,trans-[PtCl2(OH)2(c-C6H11NH2)(NH3)] (JM335) by L-cysteine, DL-penicillamine, DL-homocysteine, N-acetyl-L-cysteine, 2-mercaptopropanoic acid, 2-mercaptosuccinic acid, and glutathione has been investigated at 25 degrees C in a 1.0 M aqueous perchlorate medium with 6.8 < or = pH < or = 11.2 using stopped-flow spectrophotometry. The stoichiometry of Pt(IV):thiol is 1:2, and the redox reactions follow the second-order rate law -d[Pt(IV)]/dt = k[Pt(IV)][RSH]tot, where k denotes the pH-dependent second-order rate constant and [RSH]tot the total concentration of thiol. The pH dependence of k is ascribed to parallel reductions of JM335 by the various protolytic species of the thiols, the relative contributions of which change with pH. Electron transfer from thiol (RSH) or thiolate (RS-) to JM335 is suggested to take place as a reductive elimination process through an attack by sulfur at one of the mutually trans chloride ligands, yielding trans-[Pt(OH)2(c-C6H11NH2)(NH3)] and RSSR as the reaction products, as confirmed by 1H NMR. Second-order rate constants for the reduction of JM335 by the various protolytic species of the thiols span more than 3 orders of magnitude. Reduction with RS- is approximately 30-2000 times faster than with RSH. The linear correlation log(kRS) = (0.52 +/- 0.06)-pKRSH--(2.8 +/- 0.5) is observed, where kRS denotes the second-order rate constant for reduction of JM335 by a particular thiolate RS- and KRSH is the acid dissociation constant for the corresponding thiol RSH. The slope of the linear correlation indicates that the reactivity of the various thiolate species is governed by their proton basicity, and no significant steric effects are observed. The half-life for reduction of JM335 by 6 mM glutathione (40-fold excess) at physiologically relevant conditions of 37 degrees C and pH 7.30 is 23 s. This implies that JM335, in clinical use, is likely to undergo in vivo reduction by intracellular reducing agents such as glutathione prior to binding to DNA. Reduction results in the immediate formation of a highly reactive platinum(II) species, i.e., the bishydroxo complex in rapid protolytic equilibrium with its aqua form.