gebhart/patrepeval huggingface dataset:
One- and two-electron chemistry in the reaction of nitrogen dioxide and nitrosyl halides with binuclear pyrophosphito complexes of platinum(II) and platinum(III) (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOne- and two-electron chemistry in the reaction of nitrogen dioxide and nitrosyl halides with binuclear pyrophosphito complexes of platinum(II) and platinum(III)David Hedden, D. Max Roundhill, and Malcolm D. WalkinshawCite this: Inorg. Chem. 1985, 24, 20, 3146–3150Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://pubs.acs.org/doi/10.1021/ic00214a013https://doi.org/10.1021/ic00214a013research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
P3‐181: Ultrastructural investigation of tau‐dependent dendropathy in a triple transgenic mouse model of Alzheimer's disease (2009)

Degenerative neuronal alterations such as neuritic swellings near amyloid plaques are a prominent finding in patients suffering from Alzheimer's disease (AD). Similar dystrophies appear in transgenic mouse models of AD. Early axonopathy includes huge swellings with accumulation of microtubule-associated proteins, motor proteins, organelles, and vesicles leading to restrictions of transport and promotion of amyloid plaques. Moreover, dendritic abnormalities like spine loss, shaft atrophy, bending, abrupt branch ending, varicosity formation, and sprouting are evoked. As a suitable transgenic model for Alzheimer's disease, 3xTg-AD mice develop both beta amyloid (Aß) and tangle pathology, providing the opportunity to study degenerative processes resembling human AD-pathology. After crossing 3xTg-AD mice with a mouse line expressing yellow fluorescent protein in cortical and hippocampal neurons (YFP-H mice), we were able to perform 2-photon in vivo imaging of neurites down to the level of single dendritic spines. Investigating tau-dependent loss of spines in the somatosensory cortex, we found dendritic dystrophies which differed significantly from previously described degenerative neuritic changes: The dendritic swellings showed a distinct morphology resembling a pearl necklace and were positively stained for hyperphosphorylated tau as well as Aß. Huge varicosities surrounded a YFP-negative vacuole-like centre. In degenerative hippocampal neurites on the contrary, dystrophies near amyloid plaques contained neither hyperphosphorylated tau nor Aß, were YFP-positive throughout, and of rather spherical shape without visible interconnection. By means of electron microscopy we analyzed the ultrastructural composition of the observed neuritic swellings, answering the following questions: What is inside the cortical dendritic swellings? What does their YFP-negative centre consist of? Is there an axodendritic shift of tau like in AD? Are the observed dystrophic changes specific for dendrites or also found in axons? How do cortical and hippocampal neuritic varicosities differ on the ultrastructural level? Our studies contribute to a better understanding of tau-dependent dendropathy in 3xTg-AD mice and may also help to elucidate the cause of neuritic dystrophies in AD.
Using semiouterjoins to process queries in multidatabase systems (1984)

A multidatabase system provides a logically integrated view of existing, possibly inconsistent, databases. Logical integration is achieved primarily through the use of generalization, which can be modelled algebraically as a sequence of outerjoin and aggregation operations. Conventional distributed query processing techniques are inadequate for processing queries over views defined by outerjoins and aggregates. In a conventional distributed database system, selections and projections are inexpensive to process; hence joins have been the rocus of most previous research. In a multidatabase system, however, even selections and projections can be as expensive as joins. The semiouterjoin operation can potentially reduce query processing costs. In general, there may be many different strategies based on semiouterjoins for processing a given query. The query optimization problem is to choose the most profitable of these strategies. This paper studies the query optimization problem for selection and projection queries. It develops linear-time solutions to the problem, and then extends these solutions to provide heuristics for joins and conjunctive queries.
Abstract 12475: Mechanisms of Akt1-mediated Hypothermia Protection After Cardiac Arrest: Metabolism, Inflammation and Contractile Function (2016)

Introduction: Induction of intra-arrest cooling (IC) improves cardiac, neurological and survival outcomes in preclinical models of cardiac arrest. Previous studies demonstrate that IC protection is mediated by Akt1 activation through initiating survival signaling. Hypothesis: We hypothesize that IC-induced Akt1 activation modulates protective calcium cycling proteins, metabolic, and inflammatory pathways. Methods: Adult female Akt1 +/- underwent 8 min of KCl-induced asystolic arrest and were randomized to receive IC (30 ± 0.5°C) or normothermia (NT) before CPR (n = 10 per group). 72 h survival and mean blood pressure (MAP) were measured. Indicators of glucose utilization, inflammatory responses and contractile function in heart and brain of Akt1 +/+ and Akt1 +/- mice were assessed (n=5 per group). Results: No difference on survival was seen for IC and NT treated Akt1 +/- mice. IC induced transient improvement in MAP at 30 min following resuscitation (53.6 ± 2.2 vs 71.2 ± 2.6 mmHg p<0.05) and increased phospholamban phosphorylation in the heart of Akt1 +/+ mice which were not seen in Akt1 +/- mice. Compared to IC-treated Akt1 +/+ , pyruvate dehydrogenase phosphorylation and sorbitol accumulation were significantly increased, and NAD and ATP contents were markedly reduced in the hearts and brains of Akt1 +/- mice. IC significantly inhibited IκBα degradation and NF-κB nuclear translocation, and reduced concentrations of blood lactate and Pre-B cell Colony Enhancing Factor in Akt1 +/+ mice, but not Akt1 +/- mice. Conclusion: Akt1 is a critical mediator for TH protection during early post resuscitation in heart and brain through regulating calcium regulatory proteins, enhancing glucose utilization and downregulating inflammatory responses.
Tumor‐selective Distribution of an Active Metabolite of the 9‐Aminoanthracycline Amrubicin (1998)

It has been reported that the 9-aminoanthracycline amrubicin shows good efficacy in human tumor xenograft models. We studied the disposition and metabolism of amrubicin in mice, in comparison with those of doxorubicin. Amrubicinol, a 13-hydroxy metabolite of amrubicin, which is 10 to 100 times more cytotoxic than amrubicin, was detected as a major metabolite in blood and tissues, and aglycones of amrubicin were also detected. A pharmacokinetic study revealed that amrubicin had a smaller distribution volume and a shorter half-life than doxorubicin. In several normal tissues, the levels of amrubicin and amrubicinol were lower than those of doxorubicin. In contrast, the tumor levels of amrubicinol in the mice treated with amrubicin were higher than those of doxorubicin in the mice treated with that drug, in tumors that are sensitive to amrubicin. These results suggest that the potent therapeutic activity of amrubicin is caused by the selective distribution of its highly active metabolite, amrubicinol, in tumors.
Detection of bacteriuria by luciferase assay of adenosine triphosphate (1975)

A selective method for distinguishing bacterial and nonbacterial adenosine triphosphate (ATP) in clinical bacteriological specimens was studied. The method involved incubation of samples with the detergent Triton X-100 and the ATP-hydrolyzing enzyme apyrase. The incubation selectively destroyed ATP in suspensions of various human cells while not affecting the ATP content in microbial cells. ATP remaining in the sample after incubation was extracted in boiling buffer and assayed by the firefly luciferase assay. Application of the method to 469 clinical urine specimens showed that the ATP level after treatment with Triton/apyrase was correlated to bacterial counts and that the sensitivity of the assay was sufficient for the detection of 10(5) bacteria/ml. The ATP levels per bacterial cell remaining in the urine specimen after treatment with Triton/apyrase were close to values observed in laboratory-grown cultures. The specificity and sensitivity of the luciferase assay for the detection of urinary bacteria and its possible use as a bacteriuria screening method are discussed.
New Instrumentation and Methods for Production Logging in Multiphase Horizontal Wells (1999)

New Instrumentation and Methods for Production Logging in Multiphase Horizontal Wells David Chace; David Chace Search for other works by this author on: This Site Google Scholar Darryl Trcka; Darryl Trcka Search for other works by this author on: This Site Google Scholar Dan Georgi; Dan Georgi Search for other works by this author on: This Site Google Scholar Jianrong Wang; Jianrong Wang Search for other works by this author on: This Site Google Scholar Olaf Bousche; Olaf Bousche Search for other works by this author on: This Site Google Scholar Alex van der Spek; Alex van der Spek Search for other works by this author on: This Site Google Scholar Hassan al Nasser Hassan al Nasser Search for other works by this author on: This Site Google Scholar Paper presented at the Middle East Oil Show and Conference, Bahrain, February 1999. Paper Number: SPE-53220-MS https://doi.org/10.2118/53220-MS Published: February 20 1999 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Get Permissions Search Site Citation Chace, David, Trcka, Darryl, Georgi, Dan, Wang, Jianrong, Bousche, Olaf, van der Spek, Alex, and Hassan al Nasser. "New Instrumentation and Methods for Production Logging in Multiphase Horizontal Wells." Paper presented at the Middle East Oil Show and Conference, Bahrain, February 1999. doi: https://doi.org/10.2118/53220-MS Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll ProceedingsSociety of Petroleum Engineers (SPE)SPE Middle East Oil and Gas Show and Conference Search Advanced Search This paper was prepared for presentation at the 1999 SPE Middle East Oil Show held in Bahrain, 20-23 February 1999. Keywords: flow regime, flow rate, distribution profile, holdup image, wellbore, production monitoring, holdup, sensor, production control, inflow profile Subjects: Well & Reservoir Surveillance and Monitoring, Formation Evaluation & Management, Production logging This content is only available via PDF. 1999. Society of Petroleum Engineers You can access this article if you purchase or spend a download.
A systematic study on structural and dielectric properties of lead zirconate titanate/(Pb,La)(Zr(1−<i>x</i>)Ti(<i>x</i>))O3 thin films deposited by metallo-organic decomposition technology (1996)

Pin-hole free ferroelectric (Pb,La)(Zr1−xTix)O3 thin films with uniform composition have been fabricated using the metallo-organic precursor compounds, which were carefully home synthesized. The structural development, spectroscopic, and dielectric properties of these films have been systematically investigated using atomic force microscopy (AFM), x-ray diffraction, Fourier transform infrared spectroscopy, Raman scattering, and dielectric measurements. It has been found from our experimental results of PZT 40/60 thin films that the overlapping of (h00) and (00l) peaks of these films in x-ray diffraction patterns, mainly due to the small grain sizes in films, makes it very difficult to distinguish individual diffraction peaks and to identify the phases. However, Raman measurements undoubtedly reveal the Raman spectra of these films in the tetragonal phase field, demonstrating that Raman spectroscopy is an effective tool to identify structures, especially in the case of thin films having very small grains. AFM results show that the PZT perovskite structure in films may grow radially by rosettes and that microcracks appear in the three-dimensional AFM pictures at grain boundaries, which may be the cause for easy dielectric breakdown. A striking feature of the AFM observation is that three polycrystalline perovskite regions intersect symmetrically at a point with 120° to each other, and a rosette growth model for the perovskite structure in PZT films is thus proposed to explain this new phenomenon. The excellent ferroelectric properties of these films, such as the high fatigue resistance and low leakage current, are attributed to the high quality of the metallo-organic solutions and to reduce the amount of oxygen vacancies in the films by optimizing the annealing conditions and by doping a suitable amount of La ions to minimize the charge blocking of oxygen vacancy at the interface by Pt electrode. It seems that the rhombohedral PZT films with softer hysteresis loops are suitable for nonvolatile random access memory application.
A Predictive Model for Yeast Cell Polarization in Pheromone Gradients (2016)

Budding yeast cells exist in two mating types, a and α, which use peptide pheromones to communicate with each other during mating. Mating depends on the ability of cells to polarize up pheromone gradients, but cells also respond to spatially uniform fields of pheromone by polarizing along a single axis. We used quantitative measurements of the response of a cells to α-factor to produce a predictive model of yeast polarization towards a pheromone gradient. We found that cells make a sharp transition between budding cycles and mating induced polarization and that they detect pheromone gradients accurately only over a narrow range of pheromone concentrations corresponding to this transition. We fit all the parameters of the mathematical model by using quantitative data on spontaneous polarization in uniform pheromone concentration. Once these parameters have been computed, and without any further fit, our model quantitatively predicts the yeast cell response to pheromone gradient providing an important step toward understanding how cells communicate with each other.
Magnetic Carbon Nanotubes: A New Tool for Shepherding Mesenchymal Stem Cells by Magnetic Fields (2010)

Multiwalled CNTs hold the potential for use as nanodevices to improve therapeutic protocols for transplantation and homing of stem cells in vivo. This could pave the way for the development of new strategies for the manipulation/guidance of MSCs in regenerative medicine and cell transplantation.
A novel bioactivity of andrographolide from<i>Andrographis paniculata</i>on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis (2013)

These data suggest that andrographolide may disrupt BBB integrity, thereby deteriorating MCAO/reperfusion-induced brain injury, which are, in part, associated with its capacity to arrest cell-cycle and induce CEC apoptosis.
Spin-orbit-coupling induced domain-wall resistance in diffusive ferromagnets (2012)

We investigate diffusive transport through a number of domain wall (DW) profiles of the important magnetic alloy Permalloy taking into account simultaneously noncollinearity, alloy disorder, and spin-orbit coupling fully quantum mechanically, from first principles. In addition to observing the known effects of magnetization mistracking and anisotropic magnetoresistance, we discover a not-previously identified contribution to the resistance of a DW that comes from spin-orbit-coupling-mediated spin-flip scattering in a textured diffusive ferromagnet. This adiabatic DW resistance, which should exist in all diffusive DWs, can be observed by varying the DW width in a systematic fashion in suitably designed nanowires.
Structure and RNA recognition in recombinant STNV capsids (2011)

C411 [1]. Tat is critical for viral replication and is a potential HIV-1 vaccine candidate [2]. This intrinsically disordered protein is present in the extracellular medium and can enter neighbouring cells, in which it harbours functions involved in the pathogenicity of HIV by interacting with different cellular and viral biological partners.
Distribution of Arbuscular Mycorrhizal Fungi in Upland Field Soil of Japan 1. Relationship Between Spore Density and The Soilenvironmental Factor (2007)

To Quantify The Effects of Arbuscular Mycorrhizal Fungi (Am Fungi) On The Growth of Upland Field Crops Cultivated in Japan, We Analyzed Soil Samples From 124 Sites in 18 Japanese Prefectures For Available P Content, Ph and Am Fungal Spore Density. The Am Fungal Spore Density in The 124 Soil Samples Was 1.7 Per G Dw On The Average, and Lower Than 1.0 Per G Dry Soil (Dw) in About Half of The Soil Samples. The Maximum Spore Density Was 20.6 Spores Per G Dw. The Density of Am Fungal Spore Did Not Vary Significantly With The Sampling Site and The Kind of Cultivated Crop in The Sampling Field. The Ph of The Soil With A High Spore Density Ranged From 6 To 8, and in The Soil Samples With A Ph Lower Than 6 and Higher Than 8, TheSpore Density Was Lower Than 5 Spores Per G Dw. Thus, in The Acid Or Alkaline Soil, The Sporogenesis of Am Fungi Is Suppressed. Because Available P Content Was Consistently Low in The Soil Samples With A High Spore Density, P Content Was Considered To Correlate With The Am Fungal Spore Density. Therefore, Crop Cultivation With Limited P Fertilizer Application and Reduced Available P Content May Be Important To increase Am Fungal Spore Density in Upland Field Soil.
Comment on “Influence of the doping element on the electron mobility in <i>n</i> silicon” [J. Appl. Phys. <b>83</b>, 3096 (1998)] (1999)

Kaiblinger-Grujin, Kosina, and Selberherr [J. Appl. Phys. 83, 3096 (1998)] have proposed an explanation for the dependence of the electron mobility in n-type silicon on the doping element. We point out that their model presents some questionable aspects: The macroscopic dielectric constant is used even inside the impurity core, screening by valence electrons is double counted, and the distribution of the valence electrons around the impurity is assumed to be isotropic. We modify the model and find that the dependence on the doping element becomes too weak to explain the experimental results.
Synthesis and Molecular Structure of Germanium and Tin Tetraphenylbutadienyl Based Heterocyclic Halides (2000)

The reaction of 1,4-dilithiotetraphenylbutadiene with germanium(1V) chloride and tin(1V) chloride affords heterocycles Ph4 C4 GeCl2 , I and Ph4 C4 SnCl2 , II. Compounds I and II, which feature a planar tetraphenylbutadiene backbone, were characterize
How search engines shape the web (2005)

The state of the web today has been and continues to be greatly influenced by the existence of web-search engines. This panel will discuss the ways in which search engines have affected the web in the past and ways in which they may affect it in the future. Both positive and negative effects will be discussed as will potential measures to combat the latter. Besides the obvious ways in which search engines help people find content, other effects to be discussed include: the whole phenomenon of web-page spam, based on both text and link (e.g. link farms), the business of "Search Engine Optimization" (optimizing pages to rank highly in web-search results), the bided-terms business and the associated problem of click fraud, to name a few.
ChemInform Abstract: GENERATION OF AZASULFONIUM SALTS FROM HALOGEN-SULFIDE COMPLEXES AND ANILINES, THE SYNTHESIS OF INDOLES, OXINDOLES, AND ALKYLATED AROMATIC AMINES, BEARING CATION STABILIZING SUBSTITUENTS (1974)

Durch Modifikation der bereits beschriebenen neuen Indolsynthese gelingt die Darstellung u.a. auch von methoxylierten Indolen, die sich nach der zuerst beschriebenen Methode nicht gewinnen lassen: Durch Reaktion von Chlor mit entsprechenden Sulfiden bei niedrigen Temperaturen werden die stabilen Sulfonium-Komplexe (II), (IV) bzw. (VII) erhalten, deren Umsetzung mit den Anilinen (I) (und nachfolgend a)- mit Na-methylat, b) mit Triäthylamin bzw. c) mit Triäthylamin und HCl) die o-substituierten Aniline (III), die Indole (V) bzw. Oxindole (VIII) liefert.
IDU Therapy of Herpes Simplex (1962)

To date, there has been no well-documented description of effective therapy for any "true" viral disease, although the Chlamydozoaceae, the very large viruses, are sensitive to ordinary broad-spectrum antibiotics. To be sure, many agents, such as specific antibody or interferon, prevent the appearance of viral disease in vitro and in vivo. None of these, however, has cured or improved viral disease once it was present. Present therapy of herpes simplex keratitis with debriding agents, though helpful, is by no means uniformly satisfactory and does not eliminate virus.<sup>1</sup> This communication will report the use of a drug, 5-iodo-2'-deoxyuridine (IDU), a viral antibiotic which cures or ameliorates experimental herpes simplex keratitis,<sup>2</sup>even after the keratitis is extensive and severe. <h3>Methods and Materials</h3> The corneas of albino rabbits were traumatized by 3 interlocking circles in the central cornea made with a 5 mm. trephine set to a depth of 0.05 mm.
ChemInform Abstract: COFACIAL ASSEMBLY OF METALLOMACROCYCLES AS AN APPROACH TO CONTROLLING LATTICE ARCHITECTURE IN LOW‐DIMENSIONAL MOLECULAR SOLIDS. CHEMICAL, STRUCTURAL, OXIDATION‐STATE, TRANSPORT, AND OPTICAL PROPERTIES OF THE IRON COORDINATION POLYMER (FE(PHTHALOCYANINATO)(μ‐PYRAZINE))N AND THE CONSEQUENCES OF HALOGEN DOPING (1984)

Abstract Die Polymeren [Fe(phthalocyaninatomt‐pyrazin)]1, , (y S 3) wurden durch Reak‐ 156 tion der Titelverbindung [Fe(Pc)(p‐pyz)]" oder von Fe(Pc)(pyz)2 mit Iod in Benzol dargestellt.
Intestinimonas-like bacteria are important butyrate producers that utilize Nε-fructosyllysine and lysine in formula-fed infants and adults (2020)

Our study aim is to investigate the role of Intestinimonas, Nε-fructosyllysine (FL)-degrading bacterium, in infants and adults. We used lysine and subsequently FL in anaerobic serial dilutions of stools of infants and adults to enrich lysine and FL-degrading species. The fecal microbiota of adults were able to ferment lysine and FL to butyrate. Different groups of Intestinimonas spp. were detected from all lysine enrichments whereas the FL enrichments consisted of broader taxonomic groups with a reduced abundance of Intestinimonas-related species. Remarkably, the capability to degrade FL was only observed in formula-fed but not in breast-fed infants, which may relate to high contents of FL in formulas after thermal treatment. This possibility was supported by analyzing metagenomic datasets of 3-month and 4-month infants. Our data indicate the key role of Intestinimonas-like bacteria in FL degradation in formula-fed infants and adults as a profound example of adaptation of intestinal bacteria to dietary components.