gebhart/patrepeval huggingface dataset:
Trait Associations at the <i>Xgwm 261</i> and <i>Rht‐B1</i> Loci in Two Winter Wheat Recombinant Inbred Line Populations (2007)

Microsatellite marker locus Xgwm 261 has been associated with reduced plant height attributed to the linked gibberellic acid (GA) sensitive Rht8c allele in wheat ( Triticum aestivum L.). Our objective was to determine effects of allelic variation at the Xgwm 261 and Rht‐B1 loci in two winter wheat recombinant inbred line (RIL) populations. ‘Longhorn’/‘Akron’ and Longhorn/‘Yuma’ RIL populations were evaluated in controlled environments for GA sensitivity and coleoptile length and were grown in Colorado at five locations for 2 yr for agronomic evaluation. Microsatellite markers were used to identify alleles at the Xgwm 261 and Rht‐B1 loci. In both populations, the Rht‐B1b class showed reduced plant height (8.9% average), GA sensitivity (average 73.5%), coleoptile length (average 11.3%), and test weight (average 1.9%) relative to the Rht‐B1a class. In the Longhorn/Yuma population, Rht‐B1b and Xgwm 261 165‐bp classes were shorter than the Xgwm 261 210‐bp and Rht‐B1a classes. Increased GA sensitivity and coleoptile length of the Xgwm 261 165‐bp class were observed, although only in the Rht‐B1a background. Plant height of the Xgwm 261 165‐bp + Rht‐B1a combination was intermediate to the shorter Xgwm 261 165‐bp + Rht‐B1b and the taller Xgwm 261 ‐210‐bp + Rht‐B1a combinations. No negative associations attributed to the Xgwm 261 165‐bp allele were observed. Our results suggest that the Xgwm 261 165‐bp allele may provide reduced plant height, increased coleoptile length, and increased test weight when combined in a background with the Rht‐B1a allele.
Frequency dependent DC voltage droop control for hybrid energy storage in DC microgrids (2015)

A frequency-dependent DC voltage droop control is proposed for hybrid energy storage systems in a DC microgrid. Only local DC voltage measurement is required to realize coordination of resources with different discharge time. Stability analysis and controller optimization are studied to design the proposed controller. Example simulation results for a DC diesel-electric ship are shown. Results show promising performance of the proposed hybrid energy storage control strategy.
Endovascular Treatment of a Dissecting Posteroinferior Cerebellar Artery Aneurysm: Case Report (1996)

In patients who tolerate temporary balloon occlusion, endovascular treatment of dissecting fusiform aneurysms with platinum microembolization coils is safe and effective therapy.
Instrumentation and Surgical Technique (2013)

Prone-flexed is the standard position for percutaneous nephrolithotomy at our center, and involves 40–60º flexion at the waist and 30º at the knees. This flattens the natural lumbar lordosis and drops the buttocks, allowing improved instrumentation through lower pole tracts and a more direct view down the axis of the kidney through upper pole tracts. Relative to the flat prone position, the kidneys are lower relative to the ribs, the skin-to-calyx distance is shorter, and the liver and spleen are farther from the tract. In obese patients, neither prone nor supine positioning may be feasible due largely to increased ventilation pressures, and the lateral-flexed position is preferable. The bull's-eye fluoroscopic access technique, used in the prone-flexed position, is not used when lateral-flexed, as the C-arm cannot be rotated sufficiently. Instead, the triangulation technique is used. A step-by-step approach to percutaneous nephrolithotomy in the prone-flexed and lateral-flexed positions is described.
CORNERSTONE’s silicon photonics prototyping platform: present status and future outlook (Conference Presentation) (2020)

As the market adoption of silicon photonics technologies continues to rise, and ever more fabless companies enter the market, there is a clear need for a flexible device prototyping foundry service that retains the ability for device level innovation, whilst also offering a clear route to market. The CORNERSTONE platform offers an affordable multi-project-wafer (MPW) service that allows a degree of customisation, which may not be accessible at other foundries. Through the use of DUV projection lithography, fabrication processes can be easily transferred to other foundries for mass production. Additionally, the ability to exploit high resolution e-beam lithography for certain layers mimics more advanced technology nodes, should this be deemed necessary. Several silicon-on-insulator platforms enable a plethora of applications including datacoms, LIDAR and mid-IR sensing. This talk gives an overview of the present status of the CORNERSTONE platforms, and an outlook for the future.
The Periodic Focusing Ion Funnel: Theory, Design, and Experimental Characterization by High-Resolution Ion Mobility-Mass Spectrometry (2013)

Simulation-based development and experimental characterization of a DC-only ion funnel is described herein. Radial ion confinement is achieved via periodic focusing whereby a collisionally dampened effective potential is generated in the inertial frame of an ion traversing the device with appreciable velocity. The new device, termed a periodic focusing ion funnel (PF IF), provides an efficient alternative to the rf ion funnel providing high ion transmission with fewer electrodes, simplified electrical circuitry, and reduced power supply requirements. The utility of the PF IF for structural ion mobility-mass spectrometry (IM-MS) studies is demonstrated using model peptide ions (bradykinin, gramicidin S, and trpzip 1).
On the effectiveness of kerosene and toluene for activity of insecticides (1966)

Tolueneとkeroseneの連合作用を概観すれば，synergismを呈し，混用する有効成分によってはantagonismが認められる。また，施用方法および混用有効成分によって異なり一般的傾向はなく，連合作用は一般に高いsynergismからantagonismが観察された。これらのことは殺虫製剤にあって効果的処方を得るために，溶剤組成は重要な意義をもつことを示す。
The Synthesis of Olefins from Carbonyl Compounds and Phosphonic Acid Bisamides (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of Olefins from Carbonyl Compounds and Phosphonic Acid BisamidesE. J. Corey and George T. KwiatkowskiCite this: J. Am. Chem. Soc. 1966, 88, 23, 5652–5653Publication Date (Print):December 1, 1966Publication History Published online1 May 2002Published inissue 1 December 1966https://pubs.acs.org/doi/10.1021/ja00975a055https://doi.org/10.1021/ja00975a055research-articleACS PublicationsRequest reuse permissionsArticle Views447Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Image recognition of laser radar using linear SVM correlation filter (2007)

Through deducing the relationship between support vector machine (SVM) and correlation principle, the optimal hyperplane is proved as a correlation filter when the kernel function is the linear kernel. So a new correlation filter, named linear SVM correlation filter (LSCF), is proposed. The filter has not only shift-invariance, but also SVM properties. The real images of laser radar are used as experiment data, and LSCF is used to solve the in-plane rotation invariance. The results show that the filter can recognize the different rotated objects, and the correlation output is stable. The filter is insensitive to the noise and gray change, and has good discrimination ability. In the same design way, LSCF is also suitable to solve other problems of correlation distortion.
Thrombosis and Haemostasis: An interdisciplinary and translational endeavour (2007)

Editorial Focus: Thrombosis and Haemostasis: An interdisciplinary and translational endeavour -
System-wide studies of the transcriptional programming of chromatin during early hematopoietic development (2013)

Materials and methods Here we use in vitro differentiation of pluripotent mouse embryonic stem (ES) cells to macrophages as a model to identify molecular mechanisms and dynamics of transcriptional programs that define the individual cellular identities. We analyze the chromatin landscape and gene expression of the following five successive cell types that are purified by FACS according to their specific surface marker profiles: mesoderm, hemangioblast, hemogenic endothelium, hematopoietic precursors and macrophages. Genome-wide transcriptional activity of the individual cell populations was assessed by RNA sequencing and the distribution of histone modifications associated with either active or repressed regulatory elements was investigated by ChIP sequencing. Moreover, general DNA accessibility, i.e. open chromatin structure, was detected by DNase 1 digestion and subsequent genomewide sequencing.
Dynamics of the cluster model of protein folding (1979)

Abstract The cluster model of protein folding [Kanehisa, M. I. & Tsong, T. Y. (1978) J. Mol. Biol. 124 , 177–194] is further investigated for the thermodynamic and kinetic properties of protein folding–unfolding transitions. A cluster is a locally formed ordered region in the polypeptide chain due to cooperative interactions among residues. In the cluster model a cooperative term is assigned as proportional to the surface area of a globular cluster. This assignment is compared with that for the helix–coil transition of homopolypeptides, where the cooperative term is proportional to the two ends of a linear helical sequence. The dynamics of the cluster model exhibit a slow phase, which is well‐separated from other faster phases, because of the cooperative interaction of the macrosystem. This slow phase not only appears within the transition region, but can also persist well below the transition region if the cooperativity depends on the external condition. The amplitudes of certain kinetic phases can vary depending on the choice of physical parameters monitoring the reaction. Thus the same reaction may display different time courses. The qualitative aspects of the folding dynamics are as follows. In one case the rate‐limiting formation of a critical‐size cluster is followed by its rapid growth, while in the other the rate‐limiting step appears in a later stage, where preformed smaller clusters merge into larger ones. The former case is similar to the dynamics of the helix–coil transition, and the latter represents a stepwise mechanism of protein structure formation.
The Isolation of minicells (2003)

The term minicell was introduced by Adler et al. (1) for the small spherical cells produced by abnormal cell division at polar ends of certain Escherichia coli cells. The phenomenon itself however, had already been described as early as 1930 (2) for a strain of Vibrio cholera. These minicells do not contain any chromosomal DNA, but they do inherit in most cases the plasmid DNA present in the parental strain. Since plasmid-containing minicells are able to synthesize DNA, RNA, protein, and other cell components, they are specifically suited for the in vivo analysis of the gene products encoded for by their plasmid contents, in the absence of gene products encoded for by the host genome. In this chapter the isolation of minicells will be described, whereas the identification of gene products in minicells will be described in Chapter 48 . Other methods currently used to analyze the gene products of a particular stretch of DNA are the maxicell system ( Chapter 47 ) and the various DNA-dependent in vitro protein synthesis systems ( Chapter 19 ).
Nef Alleles from All Major HIV-1 Clades Activate Src-Family Kinases and Enhance HIV-1 Replication in an Inhibitor-Sensitive Manner (2012)

The HIV-1 accessory factor Nef is essential for high-titer viral replication and AIDS progression. Nef function requires interaction with many host cell proteins, including specific members of the Src kinase family. Here we explored whether Src-family kinase activation is a conserved property of Nef alleles from a wide range of primary HIV-1 isolates and their sensitivity to selective pharmacological inhibitors. Representative Nef proteins from the major HIV-1 subtypes A1, A2, B, C, F1, F2, G, H, J and K strongly activated Hck and Lyn as well as c-Src to a lesser extent, demonstrating for the first time that Src-family kinase activation is a highly conserved property of primary M-group HIV-1 Nef isolates. Recently, we identified 4-amino substituted diphenylfuropyrimidines (DFPs) that selectively inhibit Nef-dependent activation of Src-family kinases as well as HIV replication. To determine whether DFP compounds exhibit broad-spectrum Nef-dependent antiretroviral activity against HIV-1, we first constructed chimeric forms of the HIV-1 strain NL4-3 expressing each of the primary Nef alleles. The infectivity and replication of these Nef chimeras was indistinguishable from that of wild-type virus in two distinct cell lines (U87MG astroglial cells and CEM-T4 lymphoblasts). Importantly, the 4-aminopropanol and 4-aminobutanol derivatives of DFP potently inhibited the replication of all chimeric forms of HIV-1 in both U87MG and CEM-T4 cells in a Nef-dependent manner. The antiretroviral effects of these compounds correlated with inhibition of Nef-dependent activation of endogenous Src-family kinases in the HIV-infected cells. Our results demonstrate that the activation of Hck, Lyn and c-Src by Nef is highly conserved among all major clades of HIV-1 and that selective targeting of this pathway uniformly inhibits HIV-1 replication.
Magnetic resonance imaging of transfusional hemosiderosis complicating thalassemia major. (1984)

Tissue deposits of hemosiderin, a paramagnetic iron-protein complex, resulted in marked abnormalities of magnetic resonance (MR) spin-echo signal intensity within the viscera of three children with transfusional hemosiderosis and thalassemia major. In all patients the liver and bone marrow demonstrated abnormally low spin-echo intensities and the kidneys and muscles had abnormally high intensities. These observations correlate with in vitro MR observations of ferric (Fe+3) solutions, in which concentrations of ferric salts greater than 20 mmol yielded a low MR intensity signal and ferric concentrations less than 15 mmol yielded higher intensities than did water alone. MR imaging is sensitive to the tissue deposition of hemosiderin, and MR intensity appears to provide a rough measure of the amount of iron deposited.
Modeling Citizen Satisfaction with Mandatory Adoption of an E-Government Technology (2010)

While technology adoption is a major stream of research in information systems, few studies have examined the antecedents and consequences of mandatory adoption of technologies. To address this gap, we develop and test a model of mandatory citizen adoption of an e-government technology. Based on a framework that outlines the key stages associated with the launch of technology products, we identify various external factors as antecedents of four key technology adoption variables from the unified theory of acceptance and use of technology (UTAUT), i.e., performance expectancy, effort expectancy, social influence, and facilitating conditions, which ultimately impact citizen satisfaction. The four stages of technology launch and the salient antecedents in each stage are: (1) market preparation stage awareness; (2) targeting stage compatibility and self-efficacy; (3) positioning stage flexibility and avoidance of personal interaction; and (4) execution stage trust, convenience, and assistance. We test our model in a two-stage survey of 1,179 Hong Kong citizens, before and after they were issued a mandatory smart card to access e-government services. We find that the various factors tied to the different stages in launching the technology predict key technology adoption variables that, in turn, predict citizen satisfaction with e-government technology. We discuss the theoretical and practical implications for governments implementing technologies whose use by citizens is mandated.
The effect of power-drive level on the calibration of the bridge instrument for the measurement of the quartz stability (2009)

In this paper, it is shown that the amplitude-frequency effect, a well known phenomenon in quartz crystal resonator, questions the short-term stability results of quartz crystal resonators computed from phase noise measurement in passive interferometer systems. This equipment allows one to measure the inherent phase stability of quartz crystal resonators in a passive circuit without the noise usually associated with an active oscillator. The short-term stability of the resonator given by the Allan standard deviation is usually computed with the Leeson frequency. A new method to characterize the short-term stability of crystal resonators by a phase bridge system is given.
Developmental competence of mouse embryos following zona drilling using a non-contact holmium: yttrium scandian gallium garnet (Ho: YSGG) laser system (1995)

The purpose of this study was to assess the efficacy of the holmium:yttrium scandian gallium garnet (Ho:YSGG) laser, operating in a pipette-free, non-contact mode, to assist hatching and sustain normal embryonic development. Two-cell mouse embryos were recovered and assigned to laser-assisted hatching (LAH) treatment or control human tubal fluid (HTF) culture with or without serum (HTF-s, HTF-o) or with late serum supplementation (HTF-o/s). The basic experimental apparatus for LAH consisted of a stationary 2.1 microns Ho:YSGG laser beam directed through a mechanical shutter into an input port of a Zeiss Axiomat inverted microscope. Fewer (P < 0.05) embryos developed to the blastocyst stage in the HTF-s group (81%) than in the LAH (90%), HTF-o (94%) and HTF-o/s (92%) groups. The level of hatching was significantly increased (P < 0.01) after the LAH treatment (57%) compared to HTF-o/s (32%), HTF-s (18%) or HTF-o (5%). Implantation rates were not significantly impaired following the LAH treatment (21%). These data demonstrate that LAH using the Ho:YSGG laser is a simple, accurate and effective procedure for assisted hatching.
Surface-Micromachined 1MHz Oscillator with Low-Noise Pierce Configuration (1998)

A prototype high-frequency tuning fork oscillator has been fabricated and tested in an integrated surface micromachining technology. The amplifier circuitry uses a capacitive current detection method, which offers superior noise performance over previous resistive methods. The prototype device has an output frequency of 1.022 MHz and exhibits a noise floor of -8 8 dBc/Hz at a distance of 500 Hz from the carrier. The dominant source of frequency instability is the nonlinearity introduced by the use of parallel-plate actuation.
Increased susceptibility of mice to Salmonella infection following in vivo treatment with the substance P antagonist, spantide II (1996)

Successful resolution of salmonellosis in naive mice depends in large part upon IL-12-induced IFN-gamma production to eliminate this intracellular pathogen of macrophages. In the present study we questioned the contribution that expression of substance P receptors makes to the protective response following oral inoculation with a lethal dose of Salmonella. Such a relationship was suggested when oral inoculation with Salmonella induced rapid and dramatic increases in substance P receptor mRNA expression within Peyer's patches and mesenteric lymph nodes and subsequently in the spleen. The importance of substance P receptor expression in vivo was further suggested by pretreatment of mice with the substance P antagonist, spantide II, before oral inoculation with Salmonella. Mice pretreated with spantide II and then orally inoculated developed advanced salmonellosis and had significantly reduced survival rates compared with mice pretreated with a control peptide. Treatment with spantide II significantly reduced early Salmonella-induced IL-12p4O and IFN-gamma mRNA expression at mucosal sites, suggesting a mechanism for the reduced ability of spantide II-treated mice to resist this pathogen. Increased susceptibility to salmonellosis was not due to 1) spantide II-induced alterations in the uptake of this pathogen from the gut, 2) global spantide II-mediated immune suppression, or 3) nonsubstance P receptor-mediated effects of spantide II on macrophages. The ability of Salmonella to induce substance P receptor expression on cultured macrophages suggested that one mechanism for resistance against this intracellular pathogen might be a direct effect of substance P on this cell population.
Thermomechanically Controlled Erosion in Army Cannons: A Review (2006)

Metallographic characterization is presented of thermal damage of Cr-coated steel in a fired cannon; Cr and Ta coated steel in a vented-erosion-simulator; and bulk Si3N4 in laser heating. Common features of rapid crack-induced erosion are noted. (i) Cracks form normal to the surface, often permanently open, indicating tensile stress was present at some point during thermal damage. (ii) Softening of Cr and Ta coatings and Si3N4 occurs near the heated surface, verified by metallography and hot hardness. The transformation of steel beneath the coatings is used as an in-situ verification of temperatures that cause thermal damage. (iii) Crack-induced under-cutting of thermal-damage islands is observed for coatings and bulk Si3N4. A thermomechanical analysis of rapid crack-induced erosion observed in severe cannon firing and firing simulation suggests the following key failure mechanisms common to metals and Si3N4. (i) High near-bore transient temperatures increase thermal expansion compression and concurrently decrease the elevated temperature strength. For metals, the thermal compression stress greatly exceeds strength, to depths of about 0.5mm. (ii) Thermal stress exceeding strength produces compressive yielding, which, upon cooling, causes tensile residual stress and cracking. The near-bore residual tension is high enough to cause one-cycle cracking of both Cr and Ta coatings; hydrogen from combustion enters via the cracks and causes cracking in the steel below the coating. For Si3N4, cracks are encouraged by the low fracture toughness of Si3N4. (iii) Repeated thermal cycles deepen and widen cracks to form islands that can be undercut, leading to island removal and rapid erosion failure of the cannon. For Cr and Ta coatings, undercutting is by hydrogen cracking in the steel and degradation of the coating interface by combustion products that enter via the cracks. For Si3N4, undercutting is by direct thermomechanical cracking.
Activities at LINL relevant to gamma-ray laser concepts (1986)

Current and planned gamma‐ray laser activities at Lawrence Livermore National Laboratory are discussed. The construction of a new accelerator laboratory that will include a facility for gamma‐ray laser candidate searches is also discussed.