gebhart/patrepeval huggingface dataset:
Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins (2008)

The expression of lactate dehydrogenase 5 (LDH5), the major LDH isoenzyme sustaining the anaerobic transformation glycolysis was examined in B-cell non-Hodgkin lymphomas. Multi-tissue slides obtained from patients with diffuse large B-cell lymphomas (DLBCL; 95 cases), follicular lymphomas (FL; 49 cases) and from non-neoplastic lymph nodes (48 cases) were used for immuhistochemical analysis. High LDH5 expression (cytoplasmic and nuclear) was noted in 79/95 and 29/49 cases of DLBCL and FL, respectively (p = 0.002). No expression was noted in non-neoplastic lymphocytes. In DLBCL, LDH5 expression was significantly related to hypoxia inducible factor HIF1alpha, HIF2alpha, vascular endothelial growth factor (VEGF) and phosphorylated vascular endothelial growth factor receptor 2 (VEGFR2/KDR) expression. In FL, however, a significant relation was confirmed with pVEGFR2/KDR and HIF2alpha. FL cases with the highest microvessel density were those, which lacked both LDH5 and VEGF expression. It is concluded that LDH5 is highly upregulated in B-cell non-Hodgkin lymphomas and is in direct relation to HIFs expression. LDH5 expression is linked with activated VEGFR2/KDR expression in both lymphoid lesions.
EFFECTS OF TOTAL BODY CONDITIONING OR STEP-AEROBICS ON ENHANCEMENT OF STRENGTH AND AEROBIC CAPACITY 1133 (1996)

The purpose of this study was to determine if the addition of a resistance training program to a step-aerobics program would enhance strength and/or endurance. Healthy women (x±SD: 32.4±7.7) were matched and randomly assigned to a short duration (25 min) step-aerobics (SA25; n=8), a long duration (40 min) step-aerobics (SA40; n=12)), a SA25 with total-body heavy resistance (multiple set and multi-exercise) (SAR; n=10), training programs or a control group (C, n=6). All subjects completed 36 workouts(3/wk) over a 12 wk program and were tested before and after training. 1 RM strength of the shoulder press and the squat were determined via a computerized strength analysis system (Plyometric Power System). Peak aerobic power was determined on a cycle ergometer using standard open-circuit spirometry with a computerized interface for data storage and analyses. Heart rate and RPE were obtained before and with each stage of the test. All training groups significantly (p≤0.05) increased peak oxygen consumption. The magnitude of change for the SAR group was greater than the SA25 group and similar to the SA40 group. Time to exhaustion on the cycle test was greater for the SAR group than any of the other groups. The SAR group significantly increased 1 RM strength in both the squat and shoulder press. The SAR and SA40 groups demonstrated significant decreases in resting diastolic blood pressure after training. All groups demonstrated a reduction in systolic blood pressure with maximal exercise but only the SAR group also demonstrated a reduced diastolic blood pressure response. A reduction in resting heart rate was observed for all training groups. No changes were observed for the control group. These data indicate that a total body conditioning program can enhance aerobic capacity and time to exhaustion on a cycle ergometer while also increasing muscle strength. Such changes in both strength and cardiovascular function enhances the health/fitness profile of women.
MODD: a new decision diagram and representation for multiple output binary functions (2004)

This paper presents a new decision diagram (DD), called MODD, for multiple output binary and multiple-valued functions. This DD is canonic and can be made minimal with respect to a given variable order. Unlike other reported DDs, our approach can represent arbitrary combination of bits at the word-level. The preliminary results show that our representation can result in considerable memory saving [1].
Additions and Corrections-Yohimbane Derivatives. III. The Oxidative Rearrangement of Indole Alkaloids to Their Spirooxindole Analogs (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections-Yohimbane Derivatives. III. The Oxidative Rearrangement of Indole Alkaloids to Their Spirooxindole AnalogsHarold Zinnes and John Shavel, JrCite this: J. Org. Chem. 1966, 31, 12, 4327Publication Date (Print):December 1, 1966Publication History Published online30 July 2002Published inissue 1 December 1966https://pubs.acs.org/doi/10.1021/jo01350a612https://doi.org/10.1021/jo01350a612research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Factors affecting time to revision sinus surgery for nasal polyps: A 25‐year experience (2013)

The time course between sinus surgeries in patients with regrowth of nasal polyps appears to be affected by certain modifiable extrinsic factors, including smoking on the part of the patient and operative technique on the part of the surgeon. The performance of middle turbinate resection during sinus surgery appears to extend the time interval until a revision procedure is required.
Characterization, function and targeting of dendritic cell associated c-type lectin-2 (DCAL-2) (135.54) (2009)

Abstract Dendritic Cell (DC) Associated C-type Lectin Receptors (CLRs) play important roles in immunity through their abilities in antigen capturing and presentation, modulation of TLR signaling, co-stimulation and adhesion. Murine DCAL-2 (mDCAL-2/ mMICL/ mKLRL-1) is a type-II CLR with a cytosolic immunoreceptor tyrosine inhibitory motif (ITIM). Using a mAb we developed, we found that mDCAL-2 is expressed at high levels on plasmacytoid DCs (pDCs), CD8α+ DCs and a subset of CD8α- DCs, at moderate levels on immature CD4-CD8- T cells and low levels on a subset of B-cells, but not on mature T cells and NK cells. DCAL-2 expression subdivides CD8α- DCs into mDCAL-2High33D1- and mDCAL-2Low33D1+ populations. These two subsets of DCs express different levels of TLRs. In addition, these subsets have significantly distinct cytokine profiles in response to TLR ligands. Whereas mDCAL-2High33D1- produced high levels of TNFα, IL-6, IL-10 and IL-12, mDCAL-2Low33D1+ DCs produced extremely low levels of these cytokines. Thus, we hypothesize that mDCAL-2High DC subsets induce T-cell responses that are distinct from that of mDCAL-2Low DCs. To investigate what type of T-cell responses are induced through mDCAL-2 in an Ag specific manner, we developed an anti-mDCAL-2 single chain fragment variable (scFv) fused with antigens (OVA or HEL). We found that anti-mDCAL-2 scFv successfully targets mDCAL-2+ DC subsets in vivo. What type of T cell responses are induced by OVA-anti-mDCAL-2 scFv injection in OT-II transgenic mice will be presented. This study is supported by NIH grants AI52203, DE16381, and RR00166
<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>K</mml:mi></mml:math>-shell x-ray production in Ge, Rb, Y, Zr, and Ag by<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">N</mml:mi></mml:mrow><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>14</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow></mml:math>ion impact (1977)

$K$-shell x-ray production cross sections for Ge, Rb, Y, Zr, and Ag have been measured for incident $^{14}\mathrm{N}$ ions in the energy range 7-35 MeV. Ionization cross sections are calculated from atomic $K$-shell fluorescence yields and compared with the plane-wave Born approximation (PWBA) theory modified to include the effects of increased target binding energy, Coulomb deflection of the incident projectile, target polarization, and relativistic $K$-shell electron velocities. Experiment and theory are in very good agreement and indicate that the PWBA with modifications is quite appropriate for the projectile-target combinations and energy range for the measurements presented in this report.
Mercuric chloride induced autoimmune disease in Brown‐Norway rats: sequential search for anti‐basement membrane antibodies and circulating immune complexes (1982)

Mercuric chloride induces in the Brown-Norway rat a biphasic autoimmune disease characterized initially by linear IgG deposits along the glomerular basement membrane followed later by granular IgG deposition. In the present study, anti-glomerular basement membrane antibodies and immune complex-like material were sequentially assessed in serial serum samples. Both were transiently found at the same period. Glomerular linear IgG deposits were present on day 11 but circulating anti-glomerular basement membrane antibodies were only found later on day 16. Circulating immune complexes were first detectable on day 8 before the earliest granular IgG deposits were first observed in the spleen vessels on day 16. The disappearance of circulating anti-glomerular basement membrane antibodies and of circulating immune complexes, although HgCl2 injections were pursued, is in agreement with the self-limited character of mercuric chloride induced autoimmune disease and suggests the induction of immunosuppressive mechanisms.
High-security asynchronous circuit implementation of AES (2006)

The authors present a novel circuit implementation of the advanced encryption standard using self-timed dual-rail technology. The design reduces leakage of internal information through balanced power consumption, which is achieved by avoidance of glitches and by data-independent switching behaviour. The design utilises a pipeline structure with built-in controllers and novel, highly balanced security latches.
ChemInform Abstract: SYNTH. VON HETEROCYCLEN 371. MITT. SYNTH.‐WEG ZUM CAMPTOTHECIN (1971)

Abstract Der aus Picolinsäure‐1‐oxid mit Thionylchlorid in Äthanol erhältliche Ester (I) (96% Ausbeute) wird mit Phosphorylchlorid in HCl‐gesättigtem Chloroform in das Chlorderivat (II) (69%) übergeführt.
Beiträge zur Synthese und Strukturchemie einiger Alkenyl‐ und Allenylphosphane (1989)

Abstract Durch basenkatalysierte Hydrophosphorylierung von 1,3‐Diphenylpropin mit Ph 2 PH wird 2‐(Diphenylphosphino)‐1,3‐diphenyl‐1‐propen ( 1 ) erhalten, dessen Stereochemie durch Röntgenstrukturanalyse aufgeklärt wurde. Als Nebenprodukt werden auch geringe Mengen des regioisomeren 1‐(Diphenylphosphino)‐1,3‐diphenyl‐1‐propens ( 2 ) isoliert. Deprotonierung von 1 mit n ‐BuLi und nachfolgende Umsetzung mit Chlordiphenylphosphan liefert das doppelt‐phosphorylierte Produkt ( R , S )‐2,3‐Bis(diphenylphosphino)‐1,3diphenyl‐1‐propen ( 3 ). Durch Methylierung von 1 läßt sich das entsprechende Phosphoniumsalz 4 darstellen. Ebenfalls ausgehend von 1,3‐Diphenylpropin wird nach doppelter Lithiierung, gefolgt von der Umsetzung mit Chlordiphenylphosphan, das erste 1,3′Diphosphino‐substituierte Allen 5 synthetisiert. Aus diesem läßt sich durch starke Basen (RLi) eine Phosphinogruppe abspalten, wobei das Monophosphinoallen 6 entsteht. Oxidation sowie Addition von Schwefel und Selen ergeben die zugehörigen Dichalkogenide 5a – c , Hydrophosphorylierung von 5 führt auf einem anderen Weg zu 3 .
Proven and Unproven Therapy for Benign Prostatic Hyperplasia (2006)

The desire to take medicine is one feature which distinguishes man, the animal, from his fellow creatures.— William Osler1 The Food and Drug Administration (FDA) is the regulatory body charged with assessing the basic and clinical science underlying the introduction of new drugs into clinical practice and evaluating the efficacy and safety of new pharmaceutical agents, usually on the basis of data from phase 3 randomized trials. Almost always, the FDA initially limits the use of drugs it approves by requiring them to be prescribed by a physician.In contrast, herbs and other botanical products, which are defined as . . .
Application of Molecular Biology to Impotence Research (2001)

To encourage further application of molecular biology in impotence research, we have compiled a list of techniques that have been or can be used in such endeavors. While by no means complete or perfect, the list encompasses both some of the most commonly used (such as RT-PCR) and some of the most promising (such as gene chip) methods. All three levels of the gene expression hierarchy, namely, DNA, RNA, and protein, are represented in the discussion. Whenever possible, each technique is discussed with references relevant to impotence research. Interested readers therefore can trace the original or the most recent research protocols for more detailed information.
A new multichannel broadband NIRS system for quantitative monitoring of brain hemodynamics and metabolism during seizures (2019)

We present a newly developed multichannel broadband NIRS (or bNIRS) system that has the capacity to measure changes in light attenuation of 308 NIR wavelengths (610nm to 918nm) simultaneously over 16 different brain locations. To achieve this the instrument uses a lens based spectrometer with a front-illuminated CCD that has a sensor size of 26.8x26mm. This large CCD detector allows the simultaneous binning of 16 detector fibres. The software uses the UCLn algorithm to quantify the changes in oxy-, deoxy- haemoglobin concentration (HbO2, HHb) and oxidised cytochrome-coxidase (oxCCO) simultaneously over 16 different brain locations with 1second sampling rate. We demonstrate the use of the instrument in quantifying brain tissue oxygenation and metabolic activity simultaneously with electrical changes as measured with EEG in children with seizures.
Characterization of an Iron–Ruthenium Interaction in a Ferrocene Diamide Complex (2013)

Reaction of [fc(NH2)2]RuCl2(PPh3)2 (fc = 1,1'-ferrocenylene) with 2 equiv of KO(t)Bu led to the formation of a diamido ruthenium complex, [fc(NH)2]Ru(PPh3)2, whose solid-state molecular structure revealed a short Fe-Ru distance. A metal-to-metal charge transfer band was observed in the electronic absorption spectrum of [fc(NH)2]Ru(PPh3)2. The Fe-Ru interaction was characterized by resonance Raman spectroscopy for the first time and also by (1)H NMR, UV-vis, NIR, Mössbauer spectroscopy, and X-ray crystallography. Density functional theory (DFT) calculations including natural bond order analysis, Bader's atom in molecules method, and time-dependent DFT (TDDFT) provided further support that the iron-ruthenium bond is a weak donor-acceptor interaction with iron acting as the Lewis base.
Regiochemical control in the molybdenum-catalyzed reactions of trimethylsilyl- and ester-substituted allylic acetates (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegiochemical control in the molybdenum-catalyzed reactions of trimethylsilyl- and ester-substituted allylic acetatesBarry M. Trost and Mark LautensCite this: Organometallics 1983, 2, 11, 1687–1689Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/om50005a036https://doi.org/10.1021/om50005a036research-articleACS PublicationsRequest reuse permissionsArticle Views356Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New and old complex recombinant HIV-1 strains among patients with primary infection in 1996–2006 in France: The French ANRS CO06 primo cohort study (2008)

Prevalence of HIV-1 non-B subtypes has increased overtime in patients diagnosed at the time of primary infection (PHI) in France. Our objective was to characterize in detail non-B strains which could not be genetically classified into the known subtypes/Circulating Recombinant Forms (CRFs). Among 744 patients enrolled in the ANRS PRIMO Cohort since 1996, 176 (23.7%) were infected with HIV-1 non-B strains. The subtype/CRF could not be identified in RT for 15 (2%). The V3-V5 env region was sequenced and 3 strains (04FR-KZS, 06FR-CRN, 04FR-AUK) were full-length sequenced. Phylogenetic and bootscan analyses were used to characterize the mosaic structures. Among V3-V5 sequences, 6 were divergent A, 2 distantly related to E or D, 2 C, 1 B and 2 remained unclassified. 04FR-KZS, isolated in a Congolese woman infected in France, clustered with 2 previously described viruses from the Democratic Republic of Congo. They represent CRF27_cpx involving A/E/G/H/J/K/U subtypes. 06FR-CRN, isolated in a homosexual Caucasian patient, was a B/C/U recombinant involving a Brazilian C strain. 04FR-AUK, isolated in a Congolese patient infected in France, was a A/K/CRF09/U recombinant clustering from gag to vif with HIV-1 MAL. Others PHI were further observed in 2006–2007 with 1 KZS and 5 CRN-like viruses, suggesting their spread in France. This study illustrates the increasing HIV-1 diversity in France associating new (06FR-CRN) and old (CRF27_cpx and "MAL-like" 04FR-AUK) strains, which are rare in their region of origin but may have a possible founder effect in France. Our results strengthen the French guidelines recommending viro-epidemiological surveillance of HIV-1 diversity.
Human resource management in small to medium enterprises. A collective study of recruitment and selection, performance management, grievence procedures and trade unionism (2007)

There has been limited academic research in human resource management practices in small to medium enterprises. The aim of this dissertation is to look at the current state of recruitment and selection, performance management, grievance procedures and trade unions in small to medium enterprises. In order to achieve this objective a comprehensive literature review was carried out in recruitment and selection, performance management, grievance procedures and trade unions in small to medium enterprises. This was followed by interviews with human resource management representatives from four small to medium enterprises.
Collision Term in the Boltzmann Transport Equation (1960)

The scattering probability W(v,v′), associated with particles of mass m interacting by means of hard elastic collisions with moving scatterers of mass M, is obtained in terms of the corresponding scattering probability associated with scattering from rigid elastic scatterers. The collision term in the Boltzmann transport equation can then be written in a form which is convenient for handling both equilibrium and transport phenomena. The conditions of equilibrium are discussed. The approximate collision term for a distribution function of the form f(v) = f0(v) + vxg(v( is derived, and the results applied to the problem of the conductivity to microwaves of a slightly ionized gas.
Compilation tools for run-time reconfigurable designs (2002)

This paper describes a framework and tools for automating the production of designs which can be partially reconfigured at run time. The tools include: a partial evaluator, which produces configuration files for a given design, where the number of configurations can be minimised by a process, known as compile-time sequencing; an incremental configuration calculator, which takes the output of the partial evaluator and generates an initial configuration file and incremental configuration files that partially update preceding configurations; and a tool which further optimises designs for FPGAs supporting simultaneous configuration of multiple cells. While many of our techniques are independent of the design language and device used, our tools currently target Xilinx 6200 devices. Simultaneous configuration, for example, can be used to reduce the time for reconfiguring an adder to a subtractor from time linear with respect to its size to constant time at best and logarithmic time at worst.
In vitro growth factor-induced bio engineering of mature articular cartilage (2012)

Articular cartilage maturation is the postnatal development process that adapts joint surfaces to their site-specific biomechanical demands. Maturation involves gross morphological changes that occur through a process of synchronised growth and resorption of cartilage and generally ends at sexual maturity. The inability to induce maturation in biomaterial constructs designed for cartilage repair has been cited as a major cause for their failure in producing persistent cell-based repair of joint lesions. The combination of growth factors FGF2 and TGFβ1 induces accelerated articular cartilage maturation in vitro such that many molecular and morphological characteristics of tissue maturation are observable. We hypothesised that experimental growth factor-induced maturation of immature cartilage would result in a biophysical and biochemical composition consistent with a mature phenotype. Using native immature and mature cartilage as reference, we observed that growth factor-treated immature cartilages displayed increased nano-compressive stiffness, decreased surface adhesion, decreased water content, increased collagen content and smoother surfaces, correlating with a convergence to the mature cartilage phenotype. Furthermore, increased gene expression of surface structural protein collagen type I in growth factor-treated explants compared to reference cartilages demonstrates that they are still in the dynamic phase of the postnatal developmental transition. These data provide a basis for understanding the regulation of postnatal maturation of articular cartilage and the application of growth factor-induced maturation in vitro and in vivo in order to repair and regenerate cartilage defects.
TEMPORAL‐SPATIAL EXPRESSION OF TWO <i>PARACENTROTUS LIVIDUS</i> CELL SURFACE PROTEINS (1998)

The temporal expression of two cell surface proteins, called BEP1 and BEP4, during Paracentrosus lividus embryonic development was studied. These proteins are found in both monomeric and dimeric forms in egg and embryos and we have established that their specific form is related to their being in the cytoplasm or on the cell surface. The spatial distribution of BEP1 and BEP4 proteins in eggs and embryos was established by whole mount immunohistochemistry. These proteins are located in the animal part of unfertilized and fertilized eggs; thereafter they are much less represented in structures derived from the vegetal cells of the embryo such as the micromeres of the 16 cell stage, the primary mesenchyme of blastula and the gut of gastrula. At the prism stage BEP1 and BEP4 proteins are present to some ectodermal parts and thereafter, at the pluteus stage, to the oral region.