gebhart/patrepeval huggingface dataset:
Estimates of Regression Coefficients Based on Lift Rank Covariance Matrix (2003)

We introduce a new equivariant estimation method of the parameters of the multivariate regression model with q responses and p regressors. The estimate matrix is derived from the lift rank covariance matrix (LRCM) where the lift rank vectors are based on the Oja criterion function. The k = p + q variate ranks and k + 1 variate lift ranks are constructed using hyperplanes (or fits) going through k observations. The new LRCM regression estimate and the least squares (LS) estimate are shown to be weighted sums of the elemental estimates based on these hyperplanes. The LRCM regression estimate is equivariant and convergent, has a limiting multinormal distribution, and is highly efficient in the multivariate normal case. For heavy-tailed distributions, it performs better than the standard LS estimate. Estimation of the variance-covariance matrix of the LRCM estimate is briefly discussed. The theory is illustrated by simulations and a real data example.
Pensions in the U.S. Economy (1988)

Pensions in the U.S. Economy is the fourth in a series on pensions from the National Bureau of Economic Research. For both economists and policymakers, this volume makes a valuable contribution to current research on pensions and the economics of the elderly. The contributors report on retirement saving of individuals and the saving that results from corporate funding of pension plans, and they examine particular aspects of the plans themselves from the employee's point of view. Steven F. Venti and David A. Wise offer a careful analysis of who contributes to IRAs and why. Benjamin M. Friedman and Mark Warshawsky look at the reasons more retirement saving is not used to purchase annuities. Personal saving through pension contribution is discussed by B. Douglas Bernheim and John B. Shoven in the context of recent government and corporate pension funding changes. Michael J. Boskin and John B. Shoven analyze indicators of the economic well-being of the elderly, addressing the problem of why a large fraction of the elderly remain poor despite a general improvement in the economic status of the group as a whole. The relative merits of defined contribution versus defined benefit plans, with emphasis on the risk aspects of the two types of plans for the individual, are examined by Zvi Bodie, Alan J. Marcus, and Robert C. Merton. In the final paper, pension plans and worker turnover are the focus of the discussion by Edward P. Lazear and Robert L. Moore, who propose pension option value rather than the commonly used accrued pension wealth as a measure of pension value.
Genetic Polymorphisms of XRCC1, Alcohol Consumption, and the Risk of Colorectal Cancer in Japan (2011)

The findings are additional evidence that individuals with the XRCC1 399Gln/Gln genotype have an increased risk of colorectal cancer, and that XRCC1 polymorphisms have an important role in colorectal cancer risk associated with alcohol consumption or gene-gene interaction.
Approximate String Matching with Gaps (2002)

In this paper we consider several new versions of approximate string matching with gaps. The main characteristic of these new versions is the existence of gaps in the matching of a given pattern in a text. Algorithms are sketched for each version and their time and space complexity is stated. The specific versions of approximate string matching have various applications in computerized music analysis.
Ionization of reactive lysyl residue of myosin subfragment 1 (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIonization of reactive lysyl residue of myosin subfragment 1Andras Muhlrad and Reiji TakashiCite this: Biochemistry 1981, 20, 24, 6749–6754Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/bi00527a002https://doi.org/10.1021/bi00527a002research-articleACS PublicationsRequest reuse permissionsArticle Views18Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The regulation of leaf elongation and xyloglucan endotransglycosylase by gibberellin in ‘Himalaya’ barley (<i>Hordeum vulgare</i>L.) (1996)

The potential role of xyloglucan endotransglycosylase (XET) in GA-stimulated cell elongation was investigated during leaf expansion in barley (Hordeum vulgare L.). XET activity in aqueous extracts of leaves was detected in all segments along the elongating blade of leaf 1 of seedlings, but was at highest levels in basal segments. Leaf 1 elongation rates of gibberellin (GA)-responsive dwarf mutants were lower than the wild type, and accompanied by reduced levels of XET activity. Leaf elongation rates of the dwarfs increased following treatment with gibberellic acid (GA3) associated with higher levels of XET activity. The slender mutant, crossed into a dwarfing background, exhibited high rates of leaf 1 elongation and high levels of XET activity without added GA3. The elongation of leaf 3 in a GA-responsive dwarf mutant was also studied. Treatment with GA3 resulted in blade and sheath lengths being 5-fold and 7-fold (respectively) the lengths of controls, and again there were increases in blade and sheath XET activities. To investigate the basis for changes in XET activity levels two XET-related cDNA clones were isolated. RNAs detected by the two clones occurred at the highest levels in basal segments of rapidly elongating leaves, but they had different distribution patterns along the leaf. Overall, the data indicate that an XET-like activity is detectable in barley leaves, that the activity level and related.
Kinetic Gas−Water Transfer and Gas Accumulation in Porous Media during Pulsed Oxygen Sparging (2007)

Gas-water mass transfer and the transport of dissolved gases in variably saturated porous media are key processes for in-situ remediation by pulsed gas sparging. In this context, gas dissolution tests were conducted during pulsed oxygen gas injection into sand columns. The columns were recharged with anoxic water, effluents were analyzed for dissolved O2, and tracer tests were performed to detect accumulation of trapped gas. In a second series oxygen gas was blended with sulfur hexafluoride (SF6), and O2 and SF6 breakthrough curves were recorded. To interpret experimental results, a numerical model was applied that simulates multi-species kinetic mass transfer during gas dissolution. The model predicted breakthrough curves of dissolved gas species and delivered spatially resolved values for gas phase accumulation and composition, which are not directly accessible experimentally. It was shown how dissolved nitrogen accumulates increasingly in trapped gas phase and inhibits its complete dissolution, in case the pulsed gas injections were operated based on O2 breakthrough only. Accumulation of nitrogen also retarded dissolved oxygen transport and thus oxygen breakthrough. Experiments plus modeling demonstrated that SF6 measurements are highly sensitive to the gas dissolution processes, and provide a more sensitive criterion for determining gas injection frequencies during pulsed biosparging.
Factors Associated With Underlying Malignancy in a Retrospective Cohort of 121 Patients With Dermatomyositis (2009)

Demographic, clinical, and laboratory features that predict underlying malignancy in patients with dermatomyositis (DM) are poorly known. We conducted a retrospective study in all adult patients with a definite (n = 75) or probable (n = 32) diagnosis of DM according to Bohan and Peter criteria or with amyopathic DM (n = 14) who were referred to 2 departments during a 13-year period. The diagnosis of malignancy-associated DM was retained if DM occurred in a context of recently diagnosed malignancy or if a malignancy was diagnosed during the 5 years following the diagnosis of DM. The Kaplan-Meier method was used to assess the cumulative incidence rates of underlying malignancy during the first 5 years of DM. Factors associated with malignancy in patients with DM were identified by Cox proportional hazards models. During the study period, 121 patients fulfilled the inclusion criteria (median age, 52 yr; range, 19-77 yr; women: 70%). For 29 of them, the diagnosis of malignancy-associated DM was retained. The cumulative incidence rate of malignancy was 21 +/- 4% and 28 +/- 5%, 1 year and 5 years after the diagnosis of DM, respectively. The median duration of follow-up of the 92 patients with no malignancy diagnosed was 36 months (range, 1-140 mo). In multivariate analysis, independent factors associated with an underlying malignancy in patients with DM were an age at diagnosis >52 years (hazard ratio [HR], 7.24; 95% confidence interval [CI], 2.35-22.31), a rapid onset of skin and/or muscular symptoms (HR, 3.11; 95% CI, 1.07-9.02), the presence of skin necrosis (HR, 3.84; 95% CI, 1.00-14.85) or periungual erythema (HR, 3.93; 95% CI, 1.16-13.24), and a low baseline level of complement factor C4 (HR, 2.74; 95% CI, 1.11-6.75). Lastly, low baseline lymphocyte count (<1500/mm(3)) was a protective factor of malignancy (HR, 0.33; 95% CI, 0.14-0.80). Taken together, these data may help physicians focus on a group of patients who might benefit from extensive evaluation for malignancy.
Load–displacement solutions for piles and shallow foundations based on deformation fields and energy conservation (2008)

The paper presents an energy approach for the prediction of non-linear foundation behaviour. The formulation entails three main stages: (a) assumption of admissible pattern functions from which displacement fields can be assembled; (b) equating external work to internal work; and (c) minimisation of internal work by variation of the displacement field using the different pattern functions. The approach is demonstrated on two problems: (a) a vertically loaded shallow foundation; and (b) laterally loaded piles. The approach is evaluated by comparison with finite difference analyses using three different constitutive models. It is shown that the approach provides a fair estimation of the overall foundation response. Under large displacements the method degenerates into conventional upper-bound calculations.
Growing Bladder-Cancer Cells In Three-Dimensional Clusters (1995)

Artificial growth process helps fill gaps in cancer research. Cell cultures more accurate as models for in vivo studies and as sources of seed cells for in vivo studies. Effected in horizontal rotating bioreactor described in companion article, Simplified Bioreactor for Growing Mammalian Cells (MSC-22060). Provides aggregates of cells needed to fill many of gaps.
Unprecedented C-Selective Interstrand Cross-Linking through <i>in Situ</i> Oxidation of Furan-Modified Oligodeoxynucleotides (2010)

Chemical reagents that form interstrand cross-links have been used for a long time in cancer therapy. They covalently link two strands of DNA, thereby blocking transcription. Cross-link repair enzymes, however, can restore the transcription processes, causing resistance to certain anti-cancer drugs. The mechanism of these cross-link repair processes has not yet been fully revealed. One of the obstacles in this study is the lack of sufficient amounts of well-defined, stable, cross-linked duplexes to study the pathways of cross-link repair enzymes. Our group has developed a cross-link strategy where a furan moiety is incorporated into oligodeoxynucleotides (ODNs). These furan-modified nucleic acids can form interstrand cross-links upon selective furan oxidation with N-bromosuccinimide. We here report on the incorporation of the furan moiety at the 2'-position of a uridine through an amido or ureido linker. The resulting modified ODNs display an unprecedented selectivity for cross-linking toward a cytidine opposite the modified residue, forming one specific cross-linked duplex, which could be isolated in good yield. Furthermore, the structure of the formed cross-linked duplexes could be unambiguously characterized.
Assessment of invasion frequencies of cultured HEp-2 cells by clinical isolates of Helicobacter pylori using an acridine orange assay. (1998)

These results may have important implications for treatment and prevention strategies for this gastric pathogen. Furthermore, the acridine orange assay may be useful for assessing, in vitro, the ability of conventional and newer antibiotics, alone or in combination, to kill intracellular H pylori organisms.
Multifield-Graphs: An Approach to Visualizing Correlations in Multifield Scalar Data (2006)

We present an approach to visualizing correlations in 3D multifield scalar data. The core of our approach is the computation of correlation fields, which are scalar fields containing the local correlations of subsets of the multiple fields. While the visualization of the correlation fields can be done using standard 3D volume visualization techniques, their huge number makes selection and handling a challenge. We introduce the Multifield-Graph to give an overview of which multiple fields correlate and to show the strength of their correlation. This information guides the selection of informative correlation fields for visualization. We use our approach to visually analyze a number of real and synthetic multifield datasets.
The biphasic response of rat vesical smooth muscle to ATP (1995)

1. Adenosine-5'-triphosphate (ATP) is known to exert a variety of biological effects via the activation of either ionotropic P2x- or G-protein coupled P2Y-purinoceptor subtypes. In this study the effects induced by ATP and ATP analogues on rat bladder strips were characterized at resting tone and in carbachol-prestimulated tissues. 2. ATP exerted a clear concentration-dependent biphasic response, which was maximal at 1 mM concentration and was characterized by an immediate and transient contraction, followed by a slower sustained relaxation. The receptor mediating contraction was susceptible to desensitization by ATP and by the ATP analogue, alpha,beta-methyleneATP (alpha,beta-meATP) showing the typical features of the P2x-purinoceptor; conversely, ATP-evoked relaxation did not undergo tachyphylaxis following either ATP or alpha,beta-meATP. 3. The slower and sustained relaxant phase seemed to be due to activation of P2Y-purinoceptors, based on responses obtained with the P2Y agonist, 2-methyl-thioATP (2-meSATP) and, more importantly, based on the clear involvement of the G-proteins. In fact, the G-protein activator, guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) significantly potentiated and the G-protein blocking agent, guanosine 5'-O-(2-thio-diphosphate) (GDP beta S) completely abolished the ATP-induced relaxation. No effects were exerted by these two G-protein modulators on the ATP-induced contraction. 4. The relaxant component of the ATP response of bladder tissue was not significantly influenced by nitro-benzyl-thioinosine (NBTI) or by 8-phenyltheophylline (8-PT), suggesting that the contribution of the ATP metabolite adenosine to this response was negligible. Moreover, relaxation evoked by ATP and by the adenosine analogue, 5'-N-ethylcarboxamidoadenosine (NECA) was additive.5. Suramin was unable to modify either the relaxant or the contractile responses of bladder strips to ATP. However, when tested on the concentration-response curve to the slowly hydrolysable P2x-agonist alpha,beta-meATP, a rightward shift was detected, suggesting that ATP contractile responses are mediated by suramine-sensitive P2x-purinoceptors.6. Uridine-5'-triphosphate (UTP) only induced a rapid and concentration-dependent contraction of the rat bladder preparation, which was not desensitized by pre-exposure to alpha,beta-meATP, suggesting that UTP responses were not mediated by the 'classical' P2X-purinoceptor.7. It is therefore concluded that both P2x- and P2y-purinoceptors, which mediate ATP-induced contraction and relaxation, respectively, are present in rat bladder. Moreover, removal of epithelium did not affect ATP-elicited contraction, whereas ATP-induced relaxation was significantly augmented. These data suggest that P2x- and P2Y- purinoceptors are localized in smooth muscle cells and that the relaxant response is probably modulated by excitatory factor(s) released by epithelial cells.
ChemInform Abstract: DIREKTE BILDUNG EINES CIS‐BROMHYDRINS AUS EINEM 8BETA‐METHYLOESTRAN‐ANALOGEN (I) (1970)

Abstract Die aus N‐Bromacetamid erzeugte Hypobromsäure reagiert mit der 8β‐Methyloestranverbindung (I) zum cis‐Bromhydrin (II).
A Simple Method for Causal Analysis of Return on IT Investment (2011)

This paper proposes a method for examining the causal relationship among investment in information technology (IT) and the organization's productivity. In this method, first a strong relationship among (1) investment in IT, (2) use of IT and (3) organization's productivity is verified using correlations. Second, the assumption that IT investment preceded improved productivity is tested using partial correlation. Finally, the assumption of what may have happened in the absence of IT investment, the so called counterfactual, is tested through forecasting productivity at different levels of investment. The paper applies the proposed method to investment in the Veterans Health Information Systems and Technology Architecture (VISTA) system. Result show that the causal analysis can be done, even with limited data. Furthermore, because the procedure relies on overall organization's productivity, it might be more objective than when the analyst picks and chooses which costs and benefits should be included in the analysis.
Alginate strings with genetically engineered fibroblasts and their application in spinal cord regeneration (2003)

We have optimized a method for producing strings of alginate bioconjugated with a laminin pentapeptide that aids in cell adhesion. These strings are 400-500 /spl mu/m in thickness and could be bundled to act as a graft at the site of injury. In vitro studies have shown that rat (NB2a) and human (SHSY5Y) neuroblastoma cell lines adhere to, and differentiate on these modified alginate strings. The strings also have the capacity to hold genetically modified fibroblasts that release neurotrophins that would aid in neuronal regeneration. These strings are strong enough to be surgically transplanted to the spinal cord, and may ultimately help in bridging the gap at the injury site.
Ultralow-power all-optical wavelength conversion in a silicon-on-insulator waveguide based on a heterogeneously integrated III-V microdisk laser (2008)

Ultralow-power all-optical wavelength conversion is presented for a silicon-on-insulator wire waveguide with a heterogeneously integrated III-V microdisk laser. The principle relies on the suppression of natural lasing from the microdisk laser by an external injection. No probe beam is needed in this configuration. Static wavelength conversion with a control power of 6.4 μW or even lower is achieved. The resonance and gain provided by the microdisk cavity are at the origin of such low control power. Dynamically, wavelength conversion using a 5 Gbps non-return-to-zero bit sequence is demonstrated in the proposed device.
Subsurface Utility Engineering Manual (2007)

The purpose of these studies was to determine if a Büchi Mini Spray Dryer B-290 (Büchi Corporation, New Castle, DE, USA) could be used to prepare blackberry extract powders containing mannitol as a thermoprotectant without extensively degrading anthocyanins and polyphenols in the resulting powders. Three blackberry puree extract samples were each prepared by sonication of puree in 30/70% ethanol/water containing 0.003% HCl. Blackberry puree extract sample 1 (S1) contained no mannitol, while blackberry puree extract sample 2 (S2) contained 3.0:1 (w/w) mannitol:berry extract, and blackberry puree extract sample 3 (S3) contained 6.3:1 (w/w) mannitol:berry extract. The levels of anthocyanins and polyphenols in reconstituted spray-dried powders produced from S1-S3 were compared to solutions of S1-S3 that were held at 4°C as controls. All extract samples could be spray-dried using the Büchi Mini Spray Dryer B-290. S1, with no mannitol, showed a 30.8% decrease in anthocyanins and a 24.1% decrease in polyphenols following spray-drying. However, S2 had a reduction in anthocyanins of only 13.8%, while polyphenols were reduced by only 6.1%. S3, with a ratio of mannitol to berry extract of 6.3:1, exhibited a 12.5% decrease in anthocyanins while the decrease in polyphenols after spray-drying was not statistically significant (P=.16). Collectively, these data indicate that a Büchi Mini Spray Dryer B-290 is a suitable platform for producing stable berry extract powders, and that mannitol is a suitable thermoprotectant that facilitates retention of thermosensitive polyphenolic species in berry extracts during spray-drying.
Parallel simulation of a high speed LAN (1994)

Simulation of communication networks is often time consuming. Parallel simulation may be used to reduce the execution time of such a simulator. However, efficient modeling and simulation of such complex applications is not a trivial task. In this paper, we discuss the results of simulating a multigigabit/s network using both an optimistic and a conservative scheme. Our experimental result on a shared memory multiprocessor indicates that the conservative approach is superior to the optimistic one for this application.
Research Roundup (2015)

In this section, Graham Cope presents a synopsis of a selection of recently published articles of interest to nurses working in the field of cardiovascular nursing. The aim of this roundup is to provide a brief overview of the research papers selected. A full reference is provided for those who wish to take a look at the research in further detail
An autopsy case of progressive supranuclear palsy with central pontine myelinolysis. (1991)

An autopsy case of progressive supranuclear palsy (PSP) associated with central pontine myelinolysis (CPM) is reported. A 73-year-old male patient suffered from gait disturbance for about 5 years. The clinical features were characterized by gradual development of supranuclear ophthalmoplegia, tremor, bradykinesia, rigidity, neck dystonia, dementia and pseudobulbar palsy at the advanced stage of his illness. Treatment with levodopa did not improve his neurological signs and symptoms. PSP or multiple system atrophy was considered as a clinical diagnosis of the patient. He died of pneumonia, acute pancreatitis and liver dysfunction in November 1985. The main neuropathological findings were neuronal loss and gliosis with neurofibrillary tangles of globose type in the globus pallidus, subthalamic nucleus, substantia nigra and dentate nucleus, and at the base of the pons, bilateral and symmetrical demyelination was found. In addition, myelin staining revealed circumscribed pallor in the cerebral white matter. The histologic diagnosis was PSP associated with CPM. An association of PSP with CPM is rare in the elderly and possible etiologic factors of both diseases were discussed.