gebhart/patrepeval huggingface dataset:
MECHANISTIC ASPECTS OF CHIRAL DISCRIMINATION ON A MOLECULAR IMPRINTED POLYMER PHASE (1999)

The mechanism of chiral selectivity of a difunctional polymer imprinted with dansyl-L-phenylalanine was investigated using the polymer as an HPLC stationary phase. Temperature studies revealed that the mass transfer of the imprinted enantiomer with the polymer was sluggish at low temperatures, leading to a non-equilibrium migration down the column. Conversely, retention of the non-imprinted enantiomer was controlled by a thermodynamic equilibrium over the entire temperature range of the study. Variation of the structure of the analyte indicated a single leading interaction between both enantiomers of dansyl-phenylalanine and the polymer phase; a hydrogen bonding interaction between the carboxylic acid group of dansyl-phenylalanine and pyridinyl sites on the polymer. Secondary processes contributing to enantioselectivity were also deduced; a hydrogen bonding interaction occurring between the imprinted enantiomer and carboxyl sites on the polymer and a precise steric fit of the amino acid side chain into th...
Identification and Characterization of a β-Globin Promoter-Binding Factor from Murine Erythroleukemia Cells (1993)

We have identified a DNA-binding activity with specificity for the beta DRE, an evolutionarily conserved transcriptional regulatory element in mammalian adult beta-globin promoters. This binding activity, which we term beta DRf, for beta-globin direct repeat factor, was detected in fractionated nuclear extracts from the murine erythroleukemia cell line and has been partially purified from undifferentiated cells. beta DRf makes symmetric contacts on the two copies of its recognition sequence on both strands and introduces a bend into the DNA helix upon binding. While the factor displays a low binding affinity for the beta DRE in isolation, it binds to the intact beta-globin promoter and DNA fragments containing multiple beta DRE-binding sites with high affinity. A correlation between beta DRf binding affinity and transcriptional activity of beta DRE mutant promoters suggests that this factor stimulates transcription of the beta-globin promoter in vivo.
Cobot with Prismatic Compliant Joint Intended for Doppler Sonography (2020)

This paper deals with a collaborative robot, i.e., cobot, coupled with a new prismatic compliant joint (PCJ) at its end-effector. The proposed collaborative solution is intended for Doppler sonography to prevent musculoskeletal disorders issues. On one hand, the Doppler sonographer’s postures are investigated based on motion capture use during the arteries examination. This study highlighted that configurations adopted by angiologists lead to the musculoskeletal disorder. On the other hand, the proposed PCJ with variable stiffness gives an intrinsic compliance to the cobot handling the probe. This feature allows preserving the human safety when both human and cobot share a common workspace. The effectiveness of the proposed solution is experimentally validated through a 7-DoF Franka Emika robot virtually coupled with the PCJ, during the execution of a trajectory performed during a Doppler ultrasound exam. The impact force criterion is considered as a safety performance.
Use of #10 Crochet Hook to Retrieve Buried Sutures (1965)

To the Editor:— Since the increased use of nonabsorbable sutures, the not infrequent suture sinus has plagued surgeon and patient alike. These tracts can persist for years with simple serous drainage, at times forming recurring abscesses. The great concern to the patient is that a serious condition, even concer, may be present. The worried patient may convert into a shopper, visiting physician after physician for reassurance. Cure is associated with great relief and gratification. These sinuses will close permanently only when the non-e absorbable suture is removed from the depths of the wound (usually the fascia, but such removal is not easy with conventional instruments). Twenty years or more ago, one of us (S. H.) first used an ordinary No. 10 crochet hook to clear up this problem. This instrument can be purchased easily for 15¢. Rarely have we failed to snag the offending suture after twisting the hook in
Effects of plastic deformation on the superconducting specific-heat transition of niobium (1979)

Effects of plastic deformation on the normal, zero-field, and mixed-state specific heat of the type-II superconductor niobium were experimentally investigated. A high-resolution ac calorimetry technique was developed and used to study the effects of plastic deformation on the specific-heat superconducting transition in fields up to 2750 Oe. A method for the analysis of high-resolution specific-heat data near the superconducting transition is presented and used to determine κ variations (within a material) caused by plastic deformation. The effects of plastic deformation on the bulk superconducting transition temperature and width are also shown. Measurements of the zero-field specific heat show a systematic increase in width of the specific-heat transition with increasing deformation as well as a small increase in Tc. Both κ and the κ variation increase with increasing plastic deformation. The analysis method allows the specific-heat data of the mixed state to be decomposed in a way consistent with previously reported anisotropy data for niobium.
Frequency of Sit-Down Patient Care Rounds, Attainment of Clinical Performance Targets, Hospitalization, and Mortality in Hemodialysis Patients (2004)

Sit-down patient rounding in hemodialysis units allows providers to focus collectively on each patient's needs and may affect patient outcomes positively. The objective was to examine whether sit-down rounding practices improve patient outcomes in a cohort of 644 adult hemodialysis patients from 75 outpatient dialysis clinics in 17 states throughout the United States who survived at least 6 mo after enrollment (average follow-up, 3.2 yr). Achievement of well-accepted 6-mo clinical performance targets of albumin (> or =3.5 g/dl), hemoglobin (> or =11 g/dl), calcium-phosphate product (<60 mg(2)/dl(2)), dose (Kt/V > or =1.2), and vascular access type (fistula); hospitalization rates; and all-cause mortality served as outcomes. Monthly or more frequent sit-down rounds were conducted in 36 (48%) of 75 clinics, representing 287 (45%) of 644 patients. More frequent sit-down rounds were positively associated with an increased chance of achieving the 6-mo clinical performance target for albumin compared with less frequent rounds (odds ratio [OR], 1.88; 95% confidence interval [CI], 1.12 to 3.15); patients who were treated at clinics with more frequent rounds also had nearly twice the odds of achieving more of the five performance targets (OR, 1.95; 95% CI, 1.11 to 3.42). After adjustment for potential confounders, patients who were treated at clinics with more frequent sit-down rounds were 32% less likely to be hospitalized (incidence rate ratio, 0.68; 95% CI, 0.51 to 0.91), had fewer hospital days per year (rate ratio, 0.50; 95% CI, 0.26 to 0.98), and were 29% less likely to die (relative hazard, 0.71; 95% CI, 0.53 to 0.95). Adjustment for some clinical performance targets attenuated the statistical significance of the association with hospitalization. More frequent sit-down rounds in hemodialysis units are associated with better patient outcomes, including an increased chance of meeting the albumin clinical performance target, decreased hospitalization, and decreased risk of mortality. This association may be due to the positive effect of collaborative discussion by the patient care team of short- and long-term care goals for individual patients.
Visualization of the Contact Force Solution Space for Multi-Limbed Robots (2005)

A new analytical method for determining, describing, and visualizing the solution space for the contact force distribution of multi-limbed robots with three feet in contact with the environment in three-dimensional space is presented. The foot contact forces are first resolved into strategically defined foot contact force components to decouple them, and then the static equilibrium equations are applied. Using the friction cone equation at each foot contact point, the problem is then transformed into a geometrical one. Using geometric properties of the friction cones and by simple manipulation of their conic sections, the entire solution space which satisfies the static equilibrium and friction constraints at each contact point can be found. Two representation schemes, the “force space graph” and the “solution volume representation,” are developed for describing and visualizing the solution space which gives an intuitive visual map of how well the solution space is formed for the given conditions of the system.
Identification of a highly mobilizable subset of human neutrophil intracellular vesicles that contains tetranectin and latent alkaline phosphatase. (1990)

Tetranectin, a protein recently identified in a wide variety of human secretory cells (Christensen, L., and I. Clemmensen. 1989. Histochemistry. 92:29-35) was found to colocalize with latent alkaline phosphatase activity in fractions well separated from azurophil granules, specific granules, gelatinase-containing granules, and plasma membranes when postnuclear supernatants of nitrogen-cavitated neutrophils were fractionated on discontinuous Percoll density gradients. Stimulation of intact neutrophils with nanomolar concentrations of FMLP, leukotriene B4, 10-100 U/ml of tumor necrosis factor, and granulocyte-macrophage colony-stimulating factor resulted in parallel release of tetranectin and translocation of alkaline phosphatase to the plasma membrane. Furthermore, intracellular pools of tetranectin and latent alkaline phosphatase were completely released from neutrophils under conditions that barely induced release of specific granules containing B12-binding protein. These findings indicate that tetranectin and latent alkaline phosphatase define an easily mobilizable population of cytoplasmic storage organelles in human neutrophils which are functionally distinguishable from azurophil, specific, and gelatinase-containing granules. These organelles may play an important role as stores of membrane proteins that are mobilized to the cell surface during stimulation by inflammatory mediators.
Regulation of global gene expression in the bone marrow microenvironment by androgen: Androgen ablation increases insulin‐like growth factor binding protein‐5 expression (2007)

Androgen suppressive therapy increases IGFBP5 in the BM microenvironment and thereby may facilitate the progression of prostate cancer.
A time‐based reservation scheme for managing handovers in satellite systems (2003)

Abstract This paper proposes a Time‐based Channel Reservation Algorithm (TCRA) suitable for managing handover and call admission control procedures in future mobile satellite systems. These systems are characterized by a high rate of handover attempts which can degrade significantly their performance. Therefore, we propose TCRA, a scheme which guarantees a null handover failure probability by managing the channel through a reservation strategy in the cells to be crossed by the user. Based on the feature that the satellite motion is predictable and deterministic, the scheme tries to maximize the channel utilization and enables the system to handle the most important number of users. The performance of the TCRA scheme has been examined by simulations and compared to the Guaranteed Handover (GH) scheme. The results show the behaviour of the algorithm and its performance. Copyright © 2003 John Wiley & Sons, Ltd.
Predictive Testing of Early CIN Behaviour by Molecular Biomarkers (2005)

Each year, 330,000 new Cervical Intraepithelial Neoplasias(CIN) occur in the European Union (EU) of which 120,000 are early CIN where grade (1, 2) indicates the progression-risk to CIN-3 and therefore determines the treatment choice. However, the Positive Predictive Value (PPV) of CIN grade to predict progression is low (10% and 20% for CIN-1 and -2 respectively, 16% on average) resulting in an enormous number of over-treatments indicating worrisome grade reproducibility.Certain molecular biomarkers such as Ki-67 have a higher PPV (30%, an improvement of 14%), which in Europe alone could improve treatment for many thousands of women per year with considerable cost reduction for the health care system. The quantitative Ki-67 prognostic model has been validated in independent retrospective and prospective studies from different laboratories. Moreover, the PPV of Ki-67 alone can be improved by additional molecular biomarkers (retinoblastoma protein = Rb, cytokeratins= CK-14/-13). Combined Ki67-Rb allows a 2-tiered progression-risk subgroup assignment as very low ( approximately 0% progression, 71% of all CIN-I/II patients)and high risk (48% progression risk, incidence 32%), leaving a small (7% of all) prognostically undetermined group (17% progression). Additional CK-14 and -13 analysis can sub-classify the high-risk in an intermediate and very high risk subgroup(with 40% and 100% progression risks respectively).Thus, molecular biomarkers are potentially important determinators of early CIN lesion behaviour. Important factors for widespread acceptance of molecular biomarkers are (1) market penetration by user-friendly equipment, (2) (inter)national keeping of GLP conditions (reproducibility, independent validation), requiring customer-driven industrial efforts,governmental measures, and additional PPV improvement to further reduce over-treatment.
A Study on Improvement in Permanent Magnet Synchronous Motor with High Permeability Magnet (2013)

This paper describes permanent magnet synchronous motors by having the characteristics of a bonded magnet. In general, most PMSMs use a Nd-Fe-B sintered magnet. Because the Nd-Fe-B sintered magnet has a high magnetic energy, it is possible to obtain high torque and high output power. On the other hand, the magnetic energy of the bonded magnet is lower than that of the Nd-Fe-B sintered magnet. However, this magnet has a higher permeability than the Nd-Fe-B sintered magnet and the eddy current is negligible. It is found that flux weakening control is useful because of the high permeability. This paper presents experimental results that verify the usability of the bonded magnet machines.
(E)- and (Z)-prop-1-en-1-ol: gas-phase generation and determination of heats of formation by mass spectrometry (1984)

F. Tureček, J. Chem. Soc., Chem. Commun., 1984, 1374 DOI: 10.1039/C39840001374
Bending induced PMD in spun erbium doped fiber (2005)

We have measured the DGD induced by bending in both active and passive erbium doped fibers. We demonstrate, both theoretically and experimentally, non-trivial behaviour of PMD in spun erbium doped fiber (EDF) when coiled to small diameters. (2 pages)
Development of long-period fiber grating coupling devices (2009)

A long-period fiber grating (LPFG) formed in a single-mode fiber is considered as an effective device to tap light from the core of fiber. This light-tapping property of the LPFG allows a new class of wavelength-selective optical couplers to be realized by using the configuration of parallel LPFGs. Over the years a number of four-port and six-port LPFG couplers with peak coupling efficiencies greater than 80% have been demonstrated. To further increase the functionality of LPFG couplers and facilitate device packaging and integration, long-period grating couplers formed in planar waveguides have also been proposed, and the preliminary results are promising. A review of these coupling devices is presented.
Relics of supersymmetry in ordinary 1-flavor QCD: Hairpin diagrams and scalar-pseudoscalar degeneracy (2007)

The large-${N}_{c}$ orientifold planar equivalence between $\mathcal{N}=1$ supersymmetric Yang-Mills theory and ordinary 1-flavor QCD suggests that low-energy quark-gluon dynamics in QCD should be constrained by the supersymmetry of the parent theory. One supersymmetry relic expected from orientifold equivalence is the approximate degeneracy of the scalar and pseudoscalar mesons in 1-flavor QCD. Here we study the role of the $q\overline{q}$ annihilation (hairpin) contributions to the meson correlators. These annihilation terms induce mass shifts of opposite sign in the scalar and pseudoscalar channels, making degeneracy plausible. Calculations of valence and hairpin correlators in quenched lattice QCD are consistent with approximate degeneracy, although the errors on the scalar hairpin are large. We also study the role of $q\overline{q}$ annihilation in the 1- and 2-flavor Nambu-Jona Lasinio model, where annihilation terms arise from the chiral field determinant representing the axial $U(1)$ anomaly. Scalar-pseudoscalar degeneracy for the 1-flavor case reduces to a constraint on the relative size of the anomalous and nonanomalous 4-fermion couplings.
High-frequency analysis of SOI lateral bipolar transistor (LBT) structure for RF analog applications (2003)

The Lateral Bipolar Transistor (LBT) on SOI substrate for RF analog applications with extrinsic base on the top of the collector n-region is analyzed. The extrinsic base affects f/sub T/ and f/sub max/ in several ways. First, it increases C/sub BC/ making it dependent on lithography resolution. Second, depending on collector-base voltage, a collector-base depletion region decreases the effective collector cross-section area thus causing the Kirk effect to occur at lower collector currents. Third, the electrons injected from emitter flow partly through the extrinsic base-collector depletion region increasing the effective transit time. With respect to those effects, the technological parameters are varied and the impact on f/sub T/ and f/sub max/ are analyzed. It is shown that the increase of f/sub T/ can be achieved without sacrificing f/sub max/ considerably only by changing device geometry, still using the same doping profile of the intrinsic transistor region.
In Vitro Evaluation of the Inhibitory Action of PGI<SUB>2</SUB> to Vasoconstrictions Induced by Various Prostaglandins, Serotonin and Hemoglobin Using the Canine Basilar Artery (1982)

Current investigations have indicated that prolonged vasoconstriction in vasospasm following subarachnoid hemorrhage due to rupture of intracranial aneurysms is the result of a combined action of various vasoconstrictive agents such as serotonin, oxyhemoglobin, thrombin and prostaglandins. PGI2 (prostacyclin), on the other hand, has been known to possess antagonistic actions to some of the above agents. To elucidate the role of PGI2 as a natural protecting factor against the occurrence of vasospasm, its inhibitory action against vasoconstrictions induced by serotonin, oxyhemoglobin, PGA2, PGD2, PGE2 and PGF2α was studied in vitro using the canine basilar artery. PGI2 in concentration of 10-6 M caused vasodilation ranging between 20 to 70% of the basal contraction developed by each agonist. Thus it was revealed that PGI2 caused a significant dilation of the artery which had been constricted by any of the above agents. Since the progressive diminution in PGI2 synthesis in experimental SAH has been previously demonstrated, the result of the present study indicates a possible benefit of the us2 of PGI2 as well as the need for preservation of PGI2 synthesis in any pharmacological treatment of vasospasm.
Assessing the Impact of Turning Vehicles on Pedestrian Level of Service at Signalized Intersections (2007)

The Highway Capacity Manual provides two methods, based on delay and space, for the assessment of pedestrian level of service (LOS) at signalized intersections. Current procedures for evaluating pedestrian LOS are examined, and results indicate that these procedures do not adequately reflect the negative impact of turning vehicles. Pedestrian LOS measures are proposed to reflect not only pedestrian delay and space but also traffic interruptions, freedom of movement, and comfort. These measures are consistent with LOS measures currently used for freeway segments and ramp merge areas. The percentage of compromised pedestrian crossings is proposed as a means to quantify the negative impact of turning vehicles on pedestrian service and as a LOS measure at signalized intersections. A pedestrian crossing is designated as compromised if a pedestrian is delayed or is forced to change travel path or speed in response to a turning vehicle. The percentage of compromised pedestrian crossings was assessed for 13 crosswalks. Results of the assessments illustrate that as right-turn volumes increase, the percentage of compromised pedestrian crossings increases. The proposed method provides an objective engineering tool for measuring the impact of turning vehicles on pedestrian service. It may be appropriate to use this measure to quantify the need for pedestrian improvements (e.g., if the percentage compromised exceeds 15%, then it may be appropriate to implement a leading pedestrian interval or other enhancement).
Pyramidal flux in an anisotropic diffusion scheme for enhancing structures in 3D images (2008)

Pyramid based methods in image processing provide a helpful framework for accelerating the propagation of information over large spatial domains, increasing the efficiency for large scale applications. Combined with an anisotropic diffusion scheme tailored to preserve the boundaries at a given level, an efficient way for enhancing large structures in 3D images is presented. In our approach, the partial differential equation defining the evolution of the intensity in the image is solved in an explicit scheme at multiple resolutions in an ascending-descending cycle. Intensity 'flux' between distant voxels is allowed, while preserving borders relative to the scale. Experiments have been performed both with phantoms and with real data from 3D Transrectal Ultrasound Imaging. The effectiveness of the method to remove speckle noise and to enhance large structures such as the prostate has been demonstrated. For instance, using two scales reduces the computation time by 87% as compared to a single scale. Furthermore, we show that the boundaries of the prostate are mainly preserved, by comparing with manually outlined edges.
Identification of a Growth Stimulant for <i>Lactobacillus sanfrancisco</i> (1981)

A compound required for the luxuriant growth of Lactobacillus sanfrancisco in laboratory media was isolated from a freshly prepared yeast extract, purified, and characterized. The stimulant was identified as a small peptide with a molecular weight of approximately 1,065, containing aspartic acid, cysteine, glutamic acid, glycine, and lysine.
Transition metal-induced activation of alkynes leading to metal carbene species: synthetic application to new π-conjugated molecules (2008)

The in situ generation of furylcarbene complexes by means of transition metals was applied to catalytic carbene reactions, such as Wittig-type olefination and cycloisomerization reactions. In the presence of [Rh(OAc)2]2 as a catalyst and triphenylphosphine as a carbene accepter, carbonyl-ene-ynes 1a reacted with benzaldehyde to give a 2-styrylfuran derivative 3a. The reaction involving phosphine-ylide formation followed by Wittig-type olefination with aldehydes was applied to synthesis of furfurylidene-containing p-extended conjugated molecules. A Ruthenium catalyst underwent cycloisomerization of 1,2-bis(carbonylenyl)acetylene 10a,b to afford 2,2'-bifuran structures. The crystal structure of 5,5'-diphenyl-2,2'-bifuran 11b was determined by X-ray crystallography. The ORTEP drawings of 11b exhibited transoid and highly planar structure. The emission bands of the bisfuran 11b were observed at 414 and 440 nm, its quantum yield (84%) was higher than that of a similar 5,5'-diphenyl-2,2'-bithiophene.