gebhart/patrepeval huggingface dataset:
Collagen Fragments Inhibit Hyaluronan Synthesis in Skin Fibroblasts in Response to Ultraviolet B (UVB) (2011)

UVB irradiation causes characteristic features of skin aging including remodeling of the dermal extracellular matrix. A key feature during this process is the up-regulation of matrix metalloproteinases and cleavage of collagen. Hyaluronic acid (HA), a major component of the dermal matrix, decreases after chronic UVB exposure. However, the factors that govern the decline of HA synthesis during the course of actinic aging are largely unknown. The aim of the present study was to explore whether collagen degradation causes inhibition of HA synthesis in human skin fibroblasts. After treatment of fibroblasts with collagen fragments (CF) in vitro, resolution of the actin cytoskeleton and inhibition of HA secretion occurred because of specific down-regulation of hyaluronan synthase 2 (HAS2) expression. The α(v)β(3)-agonist, RGDS, latrunculin A, and an inhibitor of Rho-activated kinase inhibited HAS2 expression. Conversely, blocking antibodies to α(v)β(3) abolished the down-regulation of HAS2 and the cytoskeletal effects. Furthermore, inhibition of cofilin phosphorylation in response to CF was prevented by α(v)β(3)-blocking antibodies. The key role of ERK signaling was shown by reduced nuclear accumulation of phosphoERK and of ELK-1 phosphorylation in response to CF. In addition, the ERK inhibitor PD98059 reduced HAS2 expression. Also, UVB irradiation of fibroblasts caused down-regulation of HAS2, which was sensitive to matrix metalloproteinase inhibitors and to α(v)β(3)-blocking antibodies. In conclusion, these data suggest that CF activate α(v)β(3)-integrins and in turn inhibit Rho kinase (ROCK) signaling and nuclear translocation of phosphoERK, resulting in reduced HAS2 expression. Therefore, a novel mechanism is presented how proteolytic collagen cleavage may inhibit HA synthesis in dermal fibroblasts during extrinsic skin aging.
Applications of Novel Techniques to Health Foods, Medical and Agricultural Biotechnology (2004)

Selected applications of novel techniques in Agricultural Biotechnology, Health Food formulations and Medical Biotechnology are being reviewed with the aim of unraveling future developments and policy changes that are likely to open new niches for Biotechnology and prevent the shrinking or closing the existing ones. Amongst the selected novel techniques with applications to both Agricultural and Medical Biotechnology are: immobilized bacterial cells and enzymes, microencapsulation and liposome production, genetic manipulation of microorganisms, development of novel vaccines from plants, epigenomics of mammalian cells and organisms, as well as biocomputational tools for molecular modeling related to disease and Bioinformatics. Both fundamental and applied aspects of the emerging new techniques are being discussed in relation to their anticipated impact on future biotechnology applications together with policy changes that are needed for continued success in both Agricultural and Medical Biotechnology. Several novel techniques are illustrated in an attempt to convey the most representative and powerful tools that are currently being developed for both immediate and long term applications in Agriculture, Health Food formulation and production, pharmaceuticals and Medicine. The research aspects are naturally emphasized in our review as they are key to further developments in Medical and Agricultural Biotechnology.
Human alpha satellite DNA - consensus sequence and conserved regions (1987)

Journal Article Human alpha satellite DNA - consensus sequence and conserved regions Get access B. Vissel, B. Vissel Murdoch Institute, Royal Children's HospitalRemington Road, Parkville 3052, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar K.H. Choo K.H. Choo Murdoch Institute, Royal Children's HospitalRemington Road, Parkville 3052, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 15, Issue 16, 25 August 1987, Pages 6751–6752, https://doi.org/10.1093/nar/15.16.6751 Published: 25 August 1987 Article history Received: 29 June 1987 Published: 25 August 1987
Rosamicin: In Vitro Activity Against Anaerobes and Comparison with Erythromycin (1976)

The in vitro activity of rosamicin was determined against 231 strains of anaerobic bacteria and compared with the activity of erythromycin against the same strains. Rosamicin and erythromycin had similar activity against strains of Peptostreptococcus and gram-positive nonsporeforming bacilli. Rosamicin was somewhat more active against strains of Peptococcus, Clostridium, and gram-negative anaerobes. All strains of Bacteroides fragilis tested were inhibited by 4 mug of rosamicin or less per ml, whereas only 76% of them were inhibited by this concentration of erythromycin. Rosamicin was distinctly more active against Fusobacterium nucleatum. Because of its in vitro activity, further investigation of the pharmacology of this drug is warranted.
Identification of Stage-Specific Proteins Synthesized by Rat Seminiferous Tubules1 (1983)

Experiments were conducted to determine how the cycle of the seminiferous epithelium influenced synthesis and secretion of proteins by seminiferous tubules. Tubular segments were treated with collagenase and then cultured with [35S]methionine. These myoid cell-depleted tubules isolated from different stages of the epithelial cycle exhibited, at Stages VI and XII, two distinct peaks of secretion of total radiolabeled proteins. Two-dimensional gel electrophoresis indicated that the patterns of secreted proteins from these two stages were remarkably different, while those from other stages were intermediate between those at the peaks. At least 15 proteins were secreted cyclically, many of them previously unrecognized products of the seminiferous epithelium. One product, designated Cyclic Protein-2 (CP-2), exhibited a pronounced cycle of secretion, its peak at Stage VI being 30-fold greater than at its nadir at Stages XII-XIV. Further investigation indicated that CP-2 did not appear to originate from myoid cells or dispersed germ cells but could be recovered from Sertoli cell-enriched cultures prepared from Stage VI tubules. Protein secretion by tubular segments was also characterized by immunoprecipitation with two polyspecific antisera directed against Sertoli cell products. Five secretory proteins were identified which had cycles different from one another and from CP-2. In contrast to secreted products, the synthesis of most cellular proteins by tubular segments remained relatively constant throughout the cycle. It is concluded: 1) segments of the seminiferous epithelium secrete proteins into the culture medium which are distinct from cellular proteins; 2) the synthesis of many of these proteins varies with the epithelial cycle; and 3) several of the secreted proteins are of Sertoli cell origin, including a newly identified protein, CP-2. This indicates that the morphology and the protein synthetic capacity of the seminiferous epithelium are coordinated over space and time.
Self-Assembled Hexa- <i>peri</i> -hexabenzocoronene Graphitic Nanotube (2004)

An amphiphilic hexa-peri-hexabenzocoronene self-assembles to form a pi-electronic, discrete nanotubular object. The object is characterized by an aspect ratio greater than 1000 and has a uniform, 14-nanometer-wide, open-ended hollow space, which is an order of magnitude larger than those of carbon nanotubes. The wall is 3 nanometers thick and consists of helical arrays of the pi-stacked graphene molecule, whose exterior and interior surfaces are covered by hydrophilic triethylene glycol chains. The graphitic nanotube is redox active, and a single piece of the nanotube across 180-nanometer-gap electrodes shows, upon oxidation, an electrical resistance of 2.5 megohms at 285 kelvin [corrected]. This family of molecularly engineered graphite with a one-dimensional tubular shape and a chemically accessible surface constitutes an important step toward molecular electronics.
Azo-bis Nitriles. XI.<sup>1</sup> Decomposition of Azo Compounds. Steric Factors (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAzo-bis Nitriles. XI.1 Decomposition of Azo Compounds. Steric FactorsC. G. Overberger, Warren F. Hale, M. B. Berenbaum, and A. B. FinestoneCite this: J. Am. Chem. Soc. 1954, 76, 23, 6185–6187Publication Date (Print):December 1, 1954Publication History Published online1 May 2002Published inissue 1 December 1954https://pubs.acs.org/doi/10.1021/ja01652a093https://doi.org/10.1021/ja01652a093research-articleACS PublicationsRequest reuse permissionsArticle Views163Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor (1997)

Several members of the chemokine receptor family have recently been identified as coreceptors, with CD4, for entry of human immunodeficiency virus type 1 (HIV-1) into target cells. In this report, we show that the envelope glycoproteins of several strains of HIV-2 and simian immunodeficiency virus (SIV) employ the same chemokine receptors for infection. Envelope glycoproteins from HIV-2 use CCR5 or CXCR4, while those from several strains of SIV use CCR5. Our data indicate also that some viral envelopes can use more than one coreceptor for entry and suggest that some of these coreceptors remain to be identified. To further understand how different envelope molecules use CCR5 as an entry cofactor, we show that soluble purified envelope glycoproteins (SU component) from CCR5-tropic HIV-1, HIV-2, and SIV can compete for binding of iodinated chemokine to CCR5. The competition is dependent on binding of the SU glycoprotein to cell surface CD4 and implies a direct interaction between envelope glycoproteins and CCR5. This interaction is specific since it is not observed with SU glycoprotein from a CXCR4-tropic virus or with a chemokine receptor that is not competent for viral entry (CCR1). For HIV-1, the interaction can be inhibited by antibodies specific for the V3 loop of SU. Soluble CD4 was found to potentiate binding of the HIV-2 ST and SIVmac239 envelope glycoproteins to CCR5, suggesting that a CD4-induced conformational change in SU is required for subsequent binding to CCR5. These data suggest a common fundamental mechanism by which structurally diverse HIV-1, HIV-2, and SIV envelope glycoproteins interact with CD4 and CCR5 to mediate viral entry.
Oxidative Reactions of Hydrazines. IV. Elimination of Nitrogen from 1,1-Disubstituted-2-arenesulfonhydrazides<sup>1-4</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidative Reactions of Hydrazines. IV. Elimination of Nitrogen from 1,1-Disubstituted-2-arenesulfonhydrazides1-4Louis A. CarpinoCite this: J. Am. Chem. Soc. 1957, 79, 16, 4427–4431Publication Date (Print):August 1, 1957Publication History Published online1 May 2002Published inissue 1 August 1957https://pubs.acs.org/doi/10.1021/ja01573a050https://doi.org/10.1021/ja01573a050research-articleACS PublicationsRequest reuse permissionsArticle Views1395Altmetric-Citations152LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Non-axisymmetric vibrations of a transversely isotropic piezoelectric cylinder with different types of electric boundary conditions (2007)

Coupled electro-mechanical non- axisymmetric vibrations are considered in a transversely isotropic piezoelectric cylinder with axial polarization. Solutions of the system of equations are found by exact integration using a seven functional method. The dispersion curves are plotted for propagating waves for non-axisymmetric vibrations of the cylinder. It is shown that the dispersion curves are sensitive to the form of electric boundary conditions.
Decreased Metabolism in the Cerebral Cortex in Early-Stage Huntington's Disease: A Possible Biomarker of Disease Progression? (2013)

A decrease in cortical glucose metabolism is suggested as a predictor for identifying a more rapid form of progression in patients with early-stage HD.
Coulometric Oxidation of Iodine to Iodine(I)-Bromide with Bromine Generated with Iridium Anode in Hydrogen Bromide Solution. (1983)

Etude de l'iode en tant qu'agent reducteur en l'oxydant coulometriquement dans HBr 4M en bromure d'iode (I) ou IBr 2 −
Study on the Solar Driven Absorption Cooling and Heating System Using PTC Collector (2004)

Two main topics were considered in this study. The first one is comprised of the design of solar driven absorption cooling machine (SDACM) with 5 USRT and its performance analysis theoretically. This SDACM is a single effect that could be used for low temperature of solar thermal energy. The SDACM design data were calculated by computer simulation program which was made in this study. The COP and cooling capacity of the SDACM was calculated using steady state simulation program, especially with the functions of the cooling water inlet temperature and generating hot water inlet temperature. 
The second one of study involved the design and computer simulation of the complete solar cooling system. This system included hot and cold storage tanks. These two storage tanks were designed in order to be stratified thermally by diffuser. The input deck of the TRNSYS simulation program was made for the analysis of these kinds of solar cooling systems. The parametric study, especially the influence of the collector area, storage tank volume and heating load on the system performance, was accomplished by this TRNSYS for the system optimization.
Short horizon optimal control of nonlinear systems (2004)

An optimal model predictive controller for nonlinear discrete-time systems is considered. A block input-state realization of the system, which transforms it to a square system with equal number of inputs and states, is used to develop a receding horizon optimal controller designed to decrease computational expense in relation to more traditional optimal controllers. A nonlinear feedback control law is designed where a neural network in the feedback loop is used to generate an optimal control input. The generated input approximates a solution that is minimal with respect to a quadratic cost function with parameters governing the final states and the magnitude and variation of the control input, for either regulation or tracking. A local stability and robustness analysis of the controller is also presented. A simulation example shows use of the control method.
Medical Gas Analyzers (2006)

Abstract This chapter is devoted to discussing technology and its medical application to gas analysis. Medical gas analysis is becoming an important aspect of patient safety, patient monitoring, diagnosis, and therapy. The application of technology to determine the constituents and quantifying physiologic gases is increasing in importance. For example, being able to identify respiratory gas markers of diseases such as necrotizing enterocolitis and metabolic variables that can assist in the therapeutic management of obesity are becoming recognized and of significant importance. This chapter will review current gas monitoring methods and techniques ranging from colorimetry to solid‐state sensors including state‐of‐the‐art microfluidic devices. Design considerations such as in‐line and out‐of‐line sampling, displays, alarms, calibration, and controls are also discussed.
A Comparison of Egg Production of Hatchery-Reared Brook, Brown, and Rainbow Trout (1960)

(1960). A Comparison of Egg Production of Hatchery-Reared Brook, Brown, and Rainbow Trout. The Progressive Fish-Culturist: Vol. 22, No. 1, pp. 7-10.
Invasive Fungal Disease in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant (2016)

Invasive fungal disease (IFD) remains a major cause of morbidity and mortality in pediatric patients after allogeneic hematopoietic stem cell transplant (HSCT). We analyzed the outcome of 152 consecutive pediatric patients who underwent allogeneic HSCT from 2005 to 2012: 126 of these without a history of IFD and 26 with IFD before HSCT. Antifungal prophylaxis agent was determined by the primary transplant attending. The rate of IFD after HSCT among patients with or without prior IFD was similar (7.7% with and 7.1% without a history of fungal disease before transplant). Mortality in these 2 populations did not differ (35% vs. 28%, P=0.48, χ). Patients deemed at higher risk for IFD were generally placed on voriconazole prophylaxis; however, this did not affect rates of posttransplant IFD. All-cause mortality in patients with posttransplant IFD was significantly higher than those without posttransplant IFD (67% vs. 21%, P<0.0001,χ). Identifying risk factors for posttransplant IFD remains a high priority to improve outcome of HSCT.
Coefficients and roots of polynomials which define the derivatives of the exponential of (-𝐸/𝑇) (1958)

L„[e/r]: the w-th order Laguerre polynomial. The zeros of these polynomials are of interest since they locate the extreme values of the derivatives of exp (—t/T). Furthermore, an accurate, simple computation of the Wn for values of (t/T) which occur in physical problems sometimes requires use of the polynomial roots. This occurs whenever the direct evaluation of Wn[t/T~ by synthetic division introduces at intermediate steps of the calculation numbers which are larger than the value of the polynomial. In such cases the subtraction of these larger numbers can require the use of considerably more than the usual guard figures which allow for the effect of ordinary round-off error. Fortunately the occurrence of this disastrous subtraction in synthetic division does not imply the occurrence when the polynomial is calculated using its roots
Potential predictors for the amount of intra-operative brain shift during deep brain stimulation surgery (2011)

A number of groups have reported on the occurrence of intra-operative brain shift during deep brain stimulation (DBS) surgery. This has a number of implications for the procedure including an increased chance of intra-cranial bleeding and complications due to the need for more exploratory electrodes to account for the brain shift. It has been reported that the amount of pneumocephalus or air invasion into the cranial cavity due to the opening of the dura correlates with intraoperative brain shift. Therefore, pre-operatively predicting the amount of pneumocephalus expected during surgery is of interest toward accounting for brain shift. In this study, we used 64 DBS patients who received bilateral electrode implantations and had a post-operative CT scan acquired immediately after surgery (CT-PI). For each patient, the volumes of the pneumocephalus, left ventricle, right ventricle, third ventricle, white matter, grey matter, and cerebral spinal fluid were calculated. The pneumocephalus was calculated from the CT-PI utilizing a region growing technique that was initialized with an atlas-based image registration method. A multi-atlas-based image segmentation method was used to segment out the ventricles of each patient. The Statistical Parametric Mapping (SPM) software package was utilized to calculate the volumes of the cerebral spinal fluid (CSF), white matter and grey matter. The volume of individual structures had a moderate correlation with pneumocephalus. Utilizing a multi-linear regression between the volume of the pneumocephalus and the statistically relevant individual structures a Pearson's coefficient of r = 0.4123 (p = 0.0103) was found. This study shows preliminary results that could be used to develop a method to predict the amount of pneumocephalus ahead of the surgery.
Replication timing control can be maintained in extrachromosomally amplified genes. (1991)

Extrachromosomal elements are common early intermediates of gene amplification in vivo and in cell culture. The time at which several extrachromosomal elements replicate was compared with that of the corresponding amplified or unamplified chromosomal sequences. The replication timing analysis employed a retroactive synchrony method in which fluorescence-activated cell sorting was used to obtain cells at different stages of the cell cycle. Extrachromosomally amplified Syrian hamster CAD genes (CAD is an acronym for the single gene which encodes the trifunctional protein which catalyzes the first three steps of uridine biosynthesis) replicated in a narrow window of early S-phase which was approximately the same as that of chromosomally amplified CAD genes. Similarly, extrachromosomally amplified mouse adenosine deaminase genes replicated at a discrete time in early S-phase which approximated the replication time of the unamplified adenosine deaminase gene. In contrast, the multicopy extrachromosomal Epstein-Barr virus genome replicated within a narrow window in late S-phase in latently infected human Rajii cells. The data indicate that localization within a chromosome is not required for the maintenance of replication timing control.
Management of High Grade Transitional Cell Cancer of the Upper Urinary Tract (1981)

A total of 175 patients was operated on for grade 2, 3 or 4 transitional cell epithelioma of the upper urinary tract. Followup was between 5 and 26 years. The operations involved total nephroureterectomy, simple nephrectomy and local resection. Patient survival correlated well with tumor stage and, particularly, with tumor grade, and, consistently, was inferior to that of an age and sex-matched control group. The correlation of survival and ipsilateral tumor recurrence with the type of operation suggests that patients with grade 2 tumors may benefit from total nephroureterectomy. The incidence of ipsilateral tumor recurrence (28 per cent) was high in this group. The radical procedure seems to be of no benefit to patients with grade 3 or 4 tumors. The incidence of subsequent bladder tumor was 30 per cent in patients with grades 2 and 3 tumors. The latent period ranged from 2 months to 10 years (average 23 months); 82 per cent of the tumors occurred within 3 years of treatment of the upper tract tumor.