gebhart/patrepeval huggingface dataset:
Measuring gluconeogenesis with [2-13C]glycerol and mass isotopomer distribution analysis of glucose (1995)

We tested the validity of the use of [2-13C]glycerol and of the mass isotopomer distribution analysis of glucose for measuring gluconeogenesis in vitro and in vivo. When isolated rat livers (starved for 48 h) were infused with labeled glycerol without or with lactate+pyruvate, gluconeogenesis accounted for > 90% of glucose production. When glucose was added to the infusate so that glucose produced by the liver represented only 80 or 45% of total glucose output, this dilution could be calculated from the mass isotopomer distribution of glucose. When postabsorptive and starved rats were infused with [2-13C]glycerol, gluconeogenesis accounted for 54 +/- 2 and 89 +/- 1%, respectively, of glucose production. However, accurate measures could be obtained, particularly in postabsorptive rats, only with high tracer infusion rates (representing > or = 50% of endogenous glycerol production rate). In both groups of rats, these infusion rates resulted in an increase in total glycerol turnover rate and gluconeogenesis from glycerol. In addition, hepatic concentration of glycerol 3-phosphate was increased. In conclusion, [2-13C]glycerol infusion and mass isotopomer distribution analysis of glucose appear to be useful methods for studies of gluconeogenesis in vitro and in vivo; however, accurate measurements in vivo can be obtained only at the expense of some perturbation of the metabolic pathway studied.
The angular distribution of atomic ions following the multiphoton ionisation of carbon monoxide (1990)

A laser of wavelength 600 nm, pulse length 0.6 ps and focused intensity approximately=3*1015 W cm2 is used to multiply ionise CO molecules. The fragmentation channels, for example (CO3+) implies C2++O+, are isolated using a form of triple coincidence called covariance mapping. The angular distribution of the various atomic ion pairs is found to be strongly peaked along the E vector of the highly linearly polarised laser and to a degree that increases slowly with ionisation stage.
Effect of Sn and Rare Earth Elements on Mechanical Properties and Morphology of Spheroidal Graphite in FCD450 Cast Iron (2016)

The effect of addition of Sn and rare earth element (REE) have been investigated by hardness, tensile and impact absorbed tests, microstructural analysis using optical, scanning electron and transmission electron microscopes (SEM, TEM). Values of hardness and ultimate tensile strength increased increasing with Sn contents upto 0.1 mass% with and without REE, while elongation and impact energy were decreased. Spheroidal graphite in alloys including REE and Sn became finer with increasing Sn contents, and the 0.6Sn alloy had a spheroidal graphite which has clear sphere with smooth surface as the same as alloys including Sb in our previous report. Spheroidal graphite in this study was also indexed as a graphite structure by SAED analysis.
Femtosecond Coherent Spectroscopy of Bulk ZnSe and ZnCdSe/ZnSe Quantum Wells (1994)

Femtosecond two beam, self-diffraction experiments are performed in ZnSe and ZnCdSe/ZnSe quantum wells. Degenerate wave mixing signals from the third to the thirteenth order are easily visible to the naked eye, implying that nonlinear effects in this system may already be in the nonperturbative regime. Spectrally resolved data indicate that the nonlinearities originate entirely from the excitonic resonance. In addition, the existence of four-wave mixing signals in bulk ZnSe at negative time delay suggests that exciton-exciton interaction plays an important role. Exciton-phonon interaction rates are deduced as a function of temperature in ZnSe and ZnCdSe/ZnSe quantum wells.
Few electron memories: finding the compromise between performance, variability and manufacturability at the nano-scale (2004)

The key challenges for memories that operate at the nanoscale, and are compatible with mainstream nano-scale CMOS, are in achieving the performance characteristics that are useful at massive integration and in the reproducibility necessary for manufacturing. Use of single or few electrons, by utilizing the reduced dimensions - smaller number of states and larger charging energies - while appealing as a concept, needs to address the increased variance, smaller signal, and numerous other consequences of reduced collective phenomena. Several key ideas of recent times, from the use of nanocrystals to defects and decoupling of storage from the read process, provide paths where power, speed, technology compatibility, and variability is addressed. This paper discusses several of these approaches and their attributes, focusing on finding the design compromises for usability and manufacturability.
ChemInform Abstract: Tellurium in the “No‐Solvent” Organic Synthesis of Allylic Alcohols. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Template-Based Algorithms for Connectionist Rule Extraction (1994)

Casting neural network weights in symbolic terms is crucial for interpreting and explaining the behavior of a network. Additionally, in some domains, a symbolic description may lead to more robust generalization. We present a principled approach to symbolic rule extraction based on the notion of weight templates, parameterized regions of weight space corresponding to specific symbolic expressions. With an appropriate choice of representation, we show how template parameters may be efficiently identified and instantiated to yield the optimal match to a unit's actual weights. Depending on the requirements of the application domain, our method can accommodate arbitrary disjunctions and conjunctions with O(k) complexity, simple n-of-m expressions with O(k2) complexity, or a more general class of recursive n-of-m expressions with O(k3) complexity, where k is the number of inputs to a unit. Our method of rule extraction offers several benefits over alternative approaches in the literature, and simulation results on a variety of problems demonstrate its effectiveness.
MOLECULAR PROBLEMS IN HEAT AND MASS TRANSFER: RECOMBINATION OF HYDROGEN ATOMS ON GLASS (1960)

A kinetic study of the recombination of hydrogen atoms on glass was carried out. At low temperatures, the catalytic rate appears to be limited by the adsorption process on the entire surface. At higher temperatures, it becomes controlled by the surface diffusion of adsorbed atoms to unifornfly distributed active sites. At still higher temperatures, reaction takes place directly and exclusively on the active sites. A theory is presented and describes the transition between the kinetic regime and the regime of surface diffusion. The experimental data, characterized by a complicated Arrhenius behavior, are explained by this heretofore unexplored mechanism of heterogeneous catalysis. . (auth)
NMR studies of ionomers. 3. Synthesis and microstructure of poly(ethyl acrylate‐co‐lithium acrylate) (1987)

Abstract Copolymers of ethyl acrylate (EA) with lithium acrylate (LiA) with relatively low contents of LiA units (up to 30%) were synthesized by alkaline hydrolysis of poly(EA). 13 C‐NMR spectra of these copolymers registered in a mixture of deuterated benzene with deuterated methanol (85:15 v/v) presented configurational splittings of the ester methylene, methylene main chain, and ester carbonyl group signals. Assignments of these splittings were made and Bernoulli statistics with a meso probability of 0.48 could fit both poly(EA) and poly(EA‐co‐LiA). Only the CO signal of the copolymer was sensitive to sequence distribution and indicated that the LiA units have a tendency to be isolated on the chain. Two‐dimensional HETCOR pulse sequence helped to assign the main chain proton spectrum.
A new flow cytometric approach to the analysis of DNA and a second parameter. (1996)

The CVG method presents data in unique graphic form from flow cytometry assays of DNA and a second parameter. It is relatively objective and particularly useful in analyzing specimens with multiple DNA populations.
Thermal simulation of hybrid converters for distributed power supplies (2006)

This paper deals with Finite Element Modeling applied to the thermal analysis and design of power converter boards. We built a 3D model of PCB-mounted D2PAK power MOSFETs, and validated it through a comparison with measured temperatures on an ad-hoc designed and fabricated test board. The agreement between model and experiment is excellent. The model was then applied to the thermal analysis of a 400 V to 12 V DC/DC converter. The standard FR4 PCB implementation is shown to be thermally unacceptable, with a MOSFET temperature of 128deg C for 3.5 W of dissipated power. On the other hand, the same layout on a more innovative multilayer baseplate board with a 0.5 mm copper back layer and 70 micrometer thermally conductive dielectric behaves much better, with a MOSFET temperature of 94deg C for 12 W power dissipation.
Thr 163 Phosphorylation Causes Mcl-1 Stabilization when Degradation Is Independent of the Adjacent GSK3-Targeted Phosphodegron, Promoting Drug Resistance in Cancer (2012)

The antiapoptotic Bcl-2 family member Mcl-1 is a PEST protein (containing sequences enriched in proline, glutamic acid, serine, and threonine) and is subject to rapid degradation via multiple pathways. Impaired degradation leading to the maintenance of Mcl-1 expression is an important determinant of drug resistance in cancer. Phosphorylation at Thr 163 in the PEST region, stimulated by 12-O-tetradecanoylphorbol acetic acid (TPA)-induced activation of extracellular signal-regulated kinase (ERK), is associated with Mcl-1 stabilization in BL41-3 Burkitt lymphoma cells. This contrasts with the observation that Thr 163 phosphorylation in normal fibroblasts primes glycogen synthase kinase (GSK3)-induced phosphorylation at Ser 159, producing a phosphodegron that targets Mcl-1 for degradation. In the present follow-up studies in BL41-3 cells, Mcl-1 degradation was found to be independent of the GSK3-mediated pathway, providing a parallel to emerging findings showing that Mcl-1 degradation through this pathway is lost in many different types of cancer. Findings in Mcl-1-transfected CHO cells corroborated those in BL41-3 cells in that the GSK3-targeted phosphodegron did not play a major role in Mcl-1 degradation, and a phosphomimetic T163E mutation resulted in marked Mcl-1 stabilization. TPA-treated BL41-3 cells, in addition to exhibiting Thr 163 phosphorylation and Mcl-1 stabilization, exhibited an ∼10-fold increase in resistance to multiple chemotherapeutic agents, including Ara-C, etoposide, vinblastine, or cisplatin. In these cancer cells in which Mcl-1 degradation is not dependent on the GSK3/phosphodegron-targeted pathway, ERK activation and Thr 163 phosphorylation are associated with pronounced Mcl-1 stabilization and drug resistance - effects that can be suppressed by inhibition of ERK activation.
Performance Extrapolation of Parallel Programs. (1995)

Performance Extrapolation is the process of evaluating the performance of a parallel program in a target execution environment using performance information obtained for the same program in a different execution environment. Performance extrapolation techniques are suited for rapid performance tuning of parallel programs, particularly when the target environment is unavailable. This paper describes one such technique that was developed for data-parallel C++ programs written in the pC++ language. The technique uses high-level event tracing of a n-thread pC++ program run on a uniprocessor machine together with trace-driven simulation to predict the performance of the program run on an n-processor machine. Our results show that even with high-level events, performance extrapolation techniques are effective in isolating critical factors affecting a program’s performance and for evaluating the influence of architectural and system parameters.
IKKα controls canonical TGFβ-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cells (2010)

The epithelial to mesenchymal transition (EMT) is a crucial step in tumor progression, and the TGFβ-SMAD signaling pathway is an inductor of EMT in many tumor types. One hallmark of EMT is downregulation of the adherens junction protein E-cadherin, a process mediated by transcription factors such as the zinc fingers SNAIL and SLUG. Here, we report that the catalytic IκB kinase (IKK) subunit IKKα is necessary for the silencing of E-cadherin in a Panc1 cell model of TGFβ-SMAD-mediated EMT, independently of NFκB. IKKα regulates canonical TGFβ-SMAD signaling by interacting with SMAD3 and controlling SMAD complex formation on DNA. Furthermore, we demonstrate that the TGFβ-IKKα-SMAD signaling pathway induces transcription of the genes encoding SNAIL and SLUG. In addition, we demonstrate that IKKα also modulates canonical TGFβ-SMAD signaling in human MDA-MB231 breast cancer cells, arguing for a more general impact of IKKα on the control of TGFβ-SMAD signaling. Taken together, these findings indicate that IKKα contributes to the tumor-promoting function of the TGFβ-SMAD signaling pathway in particular cancers.
33fsec Pulse Generation Through Nonlinear Propagation In Optical Fibres (1987)

The 90psec pulses from a cw mode-locked Nd:YAC laser operating at 1.32μm have been initially shortened to l.5psec by means of a fibre/grating compressor arrangement and subsequently propagated through a negatively dispersive optical fibre to generate, through high-order soliton effects, pulses as short as 33fsec. Input peak power and fibre length variations have been performed and the results compared with theoretical predictions
Sensing application of nanocellulose modified with double-walled carbon nanotube and graphitized carbon nanopowder (2011)

Electrically conductive nanocellulose films were prepared by immersion in well dispersed solutions of double walled carbon nanotubes or graphitized nanopow¬der. These solutions were prepared by using the surfactant cetyltrimethylammonium bromide (CTAB) under heating and stirring conditions which were followed by a short time sonication process. Electrospun cellulose and bacterial cellulose were used as a backbone of these films. Controllable modification of cellulose with conductive agents was performed by treatment with their dispersions for 24 – 72 hours. Electrical conductivities of the resulting films are from 0,009 S cm-1 to 0,395 S cm-1 which is higher or comparable to previously reported results.Some methods have been employed to study the electrical conductivity behavior of samples. The electrical conductance of the films displays a high sensitivity to strain when tensile stress is applied.
Synthesis of Bimodal PVC Latexes by Emulsion Polymerization: An Experimental and Modeling Study (2006)

Abstract The onset and extent of secondary particle formation in the seeded emulsion polymerization of vinyl chloride were investigated by performing a series of seeded polymerizations at different concentrations of seed latex and surfactant. It was found that, in general, both the onset and the extent of secondary particle formation are determined not only by the rate of homogeneous nucleation, but also by the rates of particle coagulation. A comparison of methods to compute the evolution of the particle size distribution in vinyl chloride emulsion polymerization was also carried out. For growth processes, the widely‐used pseudo‐bulk model gives correct answers. For processes involving particle formation, on the other hand, this model cannot be used because it neglects, among others, the effects of nucleation and coagulation on the radical number distribution. To surmount this problem, we propose to use the zero‐one‐two model, for which the full population balance equations are given here.
The effects of long delay and transmission errors on the performance of TP-4 implementations (2002)

A set of tools have been developed that allows the authors to measure and examine the effects of transmission delay and errors on the performance of TP-4 implementations. The tools give insight into both the large- and small-scale behaviors of an implementation. The authors have systematically applied these tools to a commercial implementation of TP-4. Measurements show, among other things, that a two-second one-way transmission delay and an effective bit-error rate of one error per 100000 bits can result in a 95% reduction in TP-4 throughput. The detailed statistics that were collected give insight into why transmission delay and errors affect this implementation so significantly and support a number of 'lessons learned' that could be applied to TP-4 implementations that operate more robustly across networks with long transmission delays and transmission errors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Neuropharmacological Studies on Ethanol Extracts ofValeriana officinalisL.: Behavioural and Anticonvulsant Properties (1996)

An ethanol total extract of the roots of Valeriana officinalis L. in doses equivalent to 0.5–800 mg valerian root/kg b.w.i.p. was tested in male mice for possible neuropharmacological efficacy and in this respect compared with diazepam and haloperidol. The extract did not modify spontaneous motility, nociception or body temperature, and did not produce palpebral ptosis. However, it was anticonvulsant against picrotoxin (but not pentetrazol and harman) with an ED50 between 4.5 and 6 mg/kg and it prolonged thiopental anaesthesia. After fractionation of the crude extract, the antipicrotoxin activity was present mainly in the methylene chloride fraction (ED50=0.25 mg/kg). Pure valerenic acid (12.5 mg/kg b.w.i.p.) also exerted an antipicrotoxin effect.
ChemInform Abstract: SYNTHESIS OF BENZO(A)‐ AND INDOLO(2,3‐A)QUINOLIZIDINES. A NEW ROUTE TO THE RAUWOLFIA ALKALOIDS (1978)

Abstract Vortrag gehalten auf dem "Sixth International Congress of Heterocyclic Chemistry" in Tehran Univ., Tehran, Iran, vom 9.‐13.7.
Flexibles Operationspyeloskop (1979)

Our experiences with a flexible fiberscope for nephroscopy during operation are reported. With high pressure of the irrigation fluid, good judgement of the pelviocaliceal system is possible. Sounds for coagulation and forceps for stone extraction can be introduced. We found nephroscopy helpful after stone extraction and in identification of pyelocaliceal tumours.
1/f Noise in Spectrometer-Based Optical Coherence Tomography (2008)

We document and analyze the effect of 1/f noise on the detection sensitivity of spectrometer-based optical coherence tomography systems, finding that such noise sources lead to a degradation in SNR for increasing integration times.
Processing and morphology of polystyrene/ethylene‐propylene rubber reactive and nonreactive blends (1995)

Abstract The difference between reactive and nonreactive polymer blends in terms of processing and morphology has been investigated. The glassy phases for the blends are an oxazoline functional polystyrene (PS‐Ox) and a similar non‐functional polystyrene (PS). The rubbery phases are an ethylene‐propylene rubber (EP) and a similar ethylene‐propylene rubber (EP‐MA) with 07% grafted maleic anhydride. In the case of PS‐Ox/EP‐MA blends, the oxazoline group may react with the grafted rubber functionality at the interface between the two immiscible components during blending to form a compatibilizing agent in‐situ . The nonreactive blends systems of PS‐Ox/EP and PS/EP‐MA were used for comparison to the reactive system. The blend components are rheologically matched to simplify the interpretation of the process and morphological data. The blends were prepared in a batch mixer with roller blades. The torque required for mixing was measured during the blending process. The torque traces for the reactive blends exhibited a peak in torque, attributed to the chemical reaction at the interface. The weight fraction of gel in the blends was used to measure the extent of reaction. It correlates well with the mixing torques and rheological properties. The nonreactive PS‐Ox/EP and PS/EP‐MA blends show poor interfacial adhesion between the two phases. In contrast, the reactive PS‐Ox/EP‐MA blends show excellent during annealing is also much greater for the reactive blends. Varying the functionality concentration in the PS phase shows that the dispersed phase rubber particle size is reduced by increasing the concentration of oxazoline in the matrix. Blends with no or small amounts of functionality in the PS phase exhibit yield behavior in tension. However, a level of concentration of reactive functionality may be reached where the material becomes brittle.
PYROCATECASE A NEW ENZYME CATALIZING OXIDATIVE BREAKDOWN OF PYROCATECHIN* (1950)

Journal Article PYROCATECASE A NEW ENZYME CATALIZING OXIDATIVE BREAKDOWN OF PYROCATECHIN Get access OSAMU HAYAISHI, OSAMU HAYAISHI Department of Bacteriochemistry, Research Institute for Microbial Dissases, Osaka UnversityOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar KIZO HASHIMOTO KIZO HASHIMOTO Department of Bacteriochemistry, Research Institute for Microbial Dissases, Osaka UnversityOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 37, Issue 3, November 1950, Pages 371–374, https://doi.org/10.1093/oxfordjournals.jbchem.a126205 Published: 01 November 1950 Article history Received: 07 June 1950 Published: 01 November 1950
Development of an integrated cryogenic bus for spacecraft applications (1997)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation David C. Bugby, Patrick J. Brennan, Thomas M. Davis, Joe Tomlinson, Marko Stoyanof, Larry Crawford, David S. Glaister; Development of an integrated cryogenic bus for spacecraft applications. AIP Conference Proceedings 10 January 1997; 387 (1): 613–622. https://doi.org/10.1063/1.52054 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search