gebhart/patrepeval huggingface dataset:
Sensitivity to ionising radiation of lymphocytes from Huntington's chorea patients compared to controls. (1982)

Blood samples were collected from 22 patients with Huntington's chorea and from 22 matched controls. Lymphocytes were separated from aliquots of each sample and cultures set up both from these and from further aliquots of whole blood. After 24 hours, half of each culture was subjected to X irradiation. Seventy-two hours later the percentages of live lymphocytes were estimated for each half of every culture and the viability ratio calculated for each sample. The lymphocytes derived from the patients with Huntington's chorea were found to be more susceptible to X irradiation than were the lymphocytes derived from controls. This was true both for whole blood and separated lymphocyte cultures. This susceptibility was found not to be the result of the main types of medication received by the patients. The small differences between viability ratios from patients and controls and the degree of overlap makes this test unsuitable for the prediction of asymptomatic carriers of the Huntington's chorea gene.
46.1: <i>Invited Paper</i> : Recent Progress of Light‐Emitting Diodes Based on Colloidal Quantum Dots (2015)

We report very efficient red, green, blue, and white light‐emitting diodes based on colloidal quantum dots (QLEDs) using an inverted device architecture. We also review recent research progress of QLEDs and discuss issues for realizing full‐color QLED displays.
2-(tert-Butyl)-cis-5-(p-chlorophenylthio)-trans-5-methyl-1,3-dioxolan-4-one (1992)

C 14 H 17 ClO 3 S cristallise dans C2/c avec a = 28,795, b = 8,887 et c = 12,139 A, β = 103,17 °, Z = 8; affinement jusqu'a R = 0,031. Le cycle a 5 membres a une conformation intermediaire entre une forme tordue et une enveloppe avec O1 deviant du plan des quatre autres atomes. Les groupes t-butyl et chlorophenylthio sont du meme cote du cycle.
Dynamic Simulation Model of a Vapor Compression Domestic Refrigerator Running With R134a (1996)

This paper presents a distributive dynamic model of a vapour compression domestic refrigerator in view of decreasing energy consumption.The system includes a compressor, a condenser, an evaporator, a diahatic capillary tube, a capillary tube-suction line heat exchanger and one insulation cabinet.The model of exchangers is based on the conservation equations of mass, of momentum and of energy, and includes temporal and spacial discretisation.The hermetic compressor model takes into account lubricant effect and heat exchange inside the compressor.The model of the diabatic capillary tube is distributive.The critical flow and the internal thermal exchange are taken into account.The model of the insulating cabinet (cold chamber) includes coupling of the natural convection and radiation.Once the model of each component is established, a new resolution method of the coupled mathematical model of the system, based on the mass balance, on the characteristics of the compressor and of the capillary tube, is developed.
Should Yellow Fever Vaccine be Included in the Expanded Program of Immunization in Africa? A Cost-Effectiveness Analysis for Nigeria (1993)

The cost-effectiveness of preventive yellow fever vaccination versus emergency mass vaccination campaigns for epidemic control remains a matter of controversy. Until recently, Nigeria and other anglophone countries in West Africa most severely afflicted by yellow fever epidemics have followed a policy of emergency control. The effects of including yellow fever 17D vaccine in the Expanded Program of Immunization (EPI) on the immune status of the Nigerian population was studied under conservative assumptions of vaccine coverage and efficacy. The model defined the age-specific prevalence of immunity resulting from vaccination of infants and from natural endemic infection beginning in 1991 and extending over a time horizon of 35 years. The data were used to predict the number of cases and deaths during hypothetical epidemics in 2006 and 2026, representing the historic periodicity of epidemics. A second model was used to demonstrate that a > or = 60% prevalence of immunity would preclude epidemic yellow fever transmission; under base case assumptions, this prevalence would be reached after 18 years of initiating routine yellow fever vaccination in the Guinea savannah zone, the region most often affected by epidemics. Using assumptions based on data from other African countries, the cost of adding yellow fever vaccine to the existing EPI was estimated as +0.65 per fully immunized child, whereas the cost of emergency vaccination in the face of an epidemic was estimated as +7.84/person. Vaccine coverage rates achievable by the EPI were modeled on recent successes with measles vaccine, and began in 1991 at 60%. The effective vaccine coverage rate in an emergency campaign was taken as 10%, based on recent experience. For an epidemic of moderate size in 2006 (morbidity similar to the documented outbreak in 1987), the cost-effectiveness of emergency mass immunization for control of hypothetical yellow fever epidemics was two-fold higher ($381/case and $1,904/death prevented) than that of the EPI ($763/case and $3,817/death prevented). However, despite its higher cost, the efficiency of the EPI was seven-fold greater in terms of cases and deaths prevented. In large epidemics, such as that occurring over successive years (1986-1991) in Nigeria, cost-effectiveness of the EPI exceeded that of emergency control. The EPI may also play an important role in the prevention of endemic yellow fever. Assuming annual rates of endemic yellow fever predicted by serologic surveys, routine vaccination would significantly reduce morbidity and mortality at cost-effectiveness ratios within the range for other diseases prevented by the EPI, including polio, tetanus, and diphtheria.(ABSTRACT TRUNCATED AT 400 WORDS)
Photooxidation and Reduction of Ascorbic Acid Studied by E.S.R. (1973)

The photooxidation of ascorbic acid in water at pH 4.5–11.6 was studied using electron spin resonance spectroscopy. In the presence of oxygen, only one radical is detected and its resonance lines are broad. In the absence of O 2 , better resolution is obtained and a second radical is observed. When N 2 O or H 2 O 2 is added, the second radical disappears while the concentration of first radical is increased. These results are consistent with a primary photochemical step involving ejection of an electron from the monoanion of ascorbic acid to form the ascorbate. The second radical appears to be formed by addition of a hydrated electron to the monoanion of ascorbic acid.
Detecting Drug Promiscuity Using Gaussian Ensemble Screening (2012)

Polypharmacology describes the binding of a ligand to multiple protein targets (a promiscuous ligand) or multiple diverse ligands binding to a given target (a promiscuous target). Pharmaceutical companies are discovering increasing numbers of both promiscuous drugs and drug targets. Hence, polypharmacology is now recognized as an important aspect of drug design. Here, we describe a new and fast way to predict polypharmacological relationships between drug classes quantitatively, which we call Gaussian Ensemble Screening (GES). This approach represents a cluster of molecules with similar spherical harmonic surface shapes as a Gaussian distribution with respect to a selected center molecule. Calculating the Gaussian overlap between pairs of such clusters allows the similarity between drug classes to be calculated analytically without requiring thousands of bootstrap comparisons, as in current promiscuity prediction approaches. We find that such cluster similarity scores also follow a Gaussian distribution. Hence, a cluster similarity score may be transformed into a probability value, or "p-value", in order to quantify the relationships between drug classes. We present results obtained when using the GES approach to predict relationships between drug classes in a subset of the MDL Drug Data Report (MDDR) database. Our results indicate that GES is a useful way to study polypharmacology relationships, and it could provide a novel way to propose new targets for drug repositioning.
Synthetic Antiviral Agents. I. 4-Arylmethyl-4-aryl-5-oxohexanoic Acids and Certain of Their Derivatives<sup>*,1</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic Antiviral Agents. I. 4-Arylmethyl-4-aryl-5-oxohexanoic Acids and Certain of Their Derivatives*,1EDWARD J. CRAGOE Jr. and A. M. PIETRUSZKIEWICZCite this: J. Org. Chem. 1957, 22, 11, 1338–1345Publication Date (Print):November 1, 1957Publication History Published online1 May 2002Published inissue 1 November 1957https://pubs.acs.org/doi/10.1021/jo01362a012https://doi.org/10.1021/jo01362a012research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New Dimeric Naphthopyrones from <i>Aspergillus </i><i>n</i><i>iger</i> (2002)

Three new dimeric naphthopyrones, asperpyrones A (1), B (2), and C (3), together with two known compounds, fonsecinone A (4) and aurasperone A (5), have been isolated from okara that was fermented with Aspergillus niger JV-33-48. Compounds 1, 4, and 5 showed inhibitory activity on Taq DNA polymerase.
Nanoclay-reinforced electrospun chitosan/PVA nanocomposite nanofibers for biomedical applications (2015)

Chitosan/PVA/nanoclay nanocomposite nanofibers have been prepared successfully by electrospinning. Bead-free morphology was achieved for the nanofibrous mats and the nanoclays were incorporated and distributed uniformly inside the nanofibers.
The Application of Clinical Genetics (2012)

This is what I will be responsible for as Editor-in-Chief. The team at Dove Press is a constant help with all administrative duties concerning peer reviewal, and I want to express my thanks for their prompt and reliable help.
Mutual Effects Between the Trialkylsilyl Substituents and the M <sub> <i>m</i> </sub> P <sub> <i>n</i> </sub> Cages of Phosphanediides (M = Mg, Ca, Sr, Ba, and Sn) (2005)

The phosphanediides of the alkali metals, magnesium, and tin(n) oligomerize and form spherical cages. The degree of aggregation depends strongly on the steric demand of the trialkylsilyl substituents. The partial substitution of tin atoms in [SnPSitBu3]4 preserves the heterocubane structure, the general formula for these heterocubane structures being [MnSn4-n(PR)4] with n = 0, 1, 2, and 3. Homometallic cages of the heavier alkaline earth metals show the trigonal M2P3 bipyramid as the structure-dominating motif. These bipyramids can be combined via common faces thus leading to M3P4 cages. For the less reactive arsanediides an aggregation via common corners is also observed. Homoleptic phosphanediides of the heavy alkaline earth metals are unknown as yet.
Memory effects related to deep levels in metal–oxide–semiconductor structure with nanocrystalline Si (2002)

Nanocrystalline (nc) -Si was grown on SiO2 by rapid thermal chemical vapor deposition. The tunneling oxide layer of a thickness of 4 nm was formed on p-type Si(100) by rapid thermal oxidation at 1050 °C for 30 s. Metal–oxide–semiconductor (MOS) structures were fabricated and capacitance–voltage characterization was carried out to study the memory effects of the nc-Si embedded in the MOS structure. We found the memory effect to be dominantly related to hydrogen-related traps, in addition to being influenced by the three-dimensional quantum confinement and Coulomb charge effects. Deep level transient spectroscopy reveal that the activation energies of the hydrogen-related traps are Ev+0.29 eV (H1) and Ev+0.42 eV (H2), and the capture cross sections are 4.70×10−16 cm2 and 1.44×10−15 cm2, respectively. The presence of Si–H and Si–H2 bonds was confirmed by Fourier transform infrared spectroscopy.
Preparation of functional polymer microspheres by suspension copolymerization of diallyl phthalate with carboxylic monomers (1982)

A study was made of the suspension copolymerization of diallyl phthalate (DAP) and acrylic and methacrylic acid (AAc and MAc, respectively, which were charged after delay to the suspension of partially prepolymerized DAP) and the structure of resulting gel particles. In the copolymerization of DAP with AAc, the conversion of AAc leveled off despite an appreciable amount of AAc remaining in the aqueous phase, whereas in DAP–MAc copolymerization most MAc was polymerized in the particles. The particle structure depended significantly on the mode of comonomer charge. Earlier charge of the comonomer to the reaction system resulted in the formation of particles having comonomer unit-rich surface layer. This was interpreted in terms of phase separation through loosely crosslinked structure in the particles and supported by an adsorption test using a dye and the observation of surface structure of the particles. The timing of comonomer charge changed the amount of comonomer units in the surface layer from 0.06 to 0.60 mmole/g particle.
Electrical properties of grain-oriented ferroelectric ceramics in some lanthanum modified layer-structure oxides (1981)

Abstract The effects of grain orientation and La-modification on piezoelectric properties in hot-forged (H.F.) ferroelectric ceramics of some bismuth layer structure oxides were studied, comparing them with ordinarily fired (O.F.) ones. La-modified and/or grain-oriented (H.F.) ceramics have the larger electromechanical coupling factor than non-modified and/or O.F. ones.
Shot-Peening Sensitivity of Aerospace Materials (2007)

Abstract : The U.S. Army Aviation and Missile Research Development and Engineering Command (AMRDEC), Aviation Engineering Division in Huntsville, AL requested that the U.S. Army Research Laboratory, Weapons and Materials Research Directorate at Aberdeen Proving Ground, MD develop and execute a program aimed at evaluating the shot-peening sensitivity of several aerospace materials. The materials represent the four most common metals utilized on U.S. Army aviation shot-peened components. The study had three main thrusts: to assess the variation in shot-peening intensity expected from variation shot-peening parameters, to assess the fatigue strength yielded at prescribed shot-peening intensities, and to correlate surface roughness and x-ray diffraction residual stress analysis data to those prescribed stress intensities. Once the shot-peening parameters' effect on shot-peening intensity was characterized, specific intensities and parameters were selected over an intensity range (dictated by AMRDEC) for each material to assess the sensitivity on fatigue strength.
Nitrogen loss in a nitrifying biofilm system (1999)

In a biological contactor that is part of the biological pretreatment of landfill leachate in Mechernich (Germany) nitrogen elimination of 60% or more was observed under low dissolved oxygen (DO) conditions. Ammonia was converted without accumulation of nitrite and with only little nitrate production. Interestingly, due to limited supply with organic substrate in the system, this observation cannot simply be explained by a combination of conventional autotrophic nitrification and heterotrophic denitrification. In situ hybridization with 16S rRNA-targeted probes revealed the presence of large microcolonies of at least three different types of ammonia-oxidizing bacteria in those biofilm regions where extremely high nitrogen losses occurred. These results were confirmed by comparative sequence analysis of biofilm-derived amoA (encoding the active-site polypeptide of ammonia-monooxygenase) clones for molecular fine-scale analysis of the ammonia-oxidizing population. In batch tests inoculated with biofilm material nitrogen loss occurred without dosage of organic substrate at a DO concentration of 1 mg/l. The simultaneous presence of ammonia and nitrite in the reactor induced the process of complete nitrogen elimination. N 2 was identified to be the gaseous end product of the reaction. These results indicate that under low DO concentrations autotrophic ammonia-oxidizers might be the causative agents of the observed nitrogen loss by performing aerobic/anoxic denitrification with nitrite as electron acceptor and ammonia (or perhaps hydroxylamin) as electron donor.
P-307 Mitral isthmus ablation in paroxysmal and persistent atrial fibrillation (2003)

UROPACE
Trajectory Optimization for Target Localization Using Small Unmanned Aerial Vehicles (2009)

Small unmanned aerial vehicles (UAVs) equipped with navigation and video capabilities can be used to perform target localization. Combining UAV state estimates with image data leads to bearing measurements of the target that can be processed to determine its position. This 3-D bearings-only estimation problem is nonlinear and traditional ltering methods are prone to biases, noisy estimates, and lter instabilities. The performance of the target localization is highly dependent on the vehicle trajectory, motivating the development of optimal UAV trajectories. This work presents methods for designing trajectories that increase the amount of information provided by the measurements and shows that these trajectories lead to enhanced estimation performance. The Fisher Information Matrix (FIM) is used to quantify the information provided by the measurements. Several objective functions based on the FIM are considered and the A-optimality criterion is shown to be the best suited for trajectory optimization in the 3-D bearings-only target localization problem. The resulting trajectories produce spirals, which increase the angular separation between measurements and reduce the range to the target, supporting geometric intuition. The problem of simultaneous target estimation and vehicle trajectory optimization is explored and the resulting algorithms produce vehicle trajectories that increase the information provided by the measurements, enhancing the target estimation performance by increasing accuracy, reducing uncertainty and improving lter convergence.
ChemInform Abstract: Oxidation of Aldehydes into Carboxylic Acids with Molecular Oxygen Using Nickel(II) Complex Catalyst. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A high P–T cell assembly for neutron diffraction up to 10GPa and 1500 K (1999)

Abstract We present the design of a cell assembly for neutron diffraction experiments capable of performing simultaneous high-pressure (P) and high-temperature (T) conditions up to 10GPa and 1500 K. The high P-T cell assembly, designed for a Paris-Edinburgh (PE) toroidal anvil press, consists of a ceramic gasket, a cylinder/disk furnace, a confining ring, two thermocouples, and platinum wires which serve as electrodes for ohmic heating of the sample. The properties of mechanical strength, yield strength for plastic deformation, thermal/electric insulation, and neutron transparency of the gasket materials are the keys to the success of the cell assembly. The high P-T neutron diffraction experiments conducted at the HIPD beam-line at LANSCE using this cell assembly have produced high quality data and with stable, uniform temperature and sustained hydrostatic pressure.
General procedure for the analysis of Er^3+ cross sections (1991)

We have applied the theory of McCumber to the (4)4I(13/2) ? (4)I(15/2) transition of Er(3+) -doped glasses and confirmed its ability to provide both spectra and accurate values of cross sections. For an Al/P-silica fiber, the exact McCumber treatment is within 3% of the measured emission cross section, whereas an Einstein analysis is off by >50%. An approximate treatment that eliminates the McCumber theory's requirement of detailed electronic structure has been developed and found to usually provide more accurate values than an Einstein analysis.
Structure−Activity Relationship Studies Optimizing the Antiproliferative Activity of Novel Cyclic Somatostatin Analogues Containing a Restrained Cyclic β-Amino Acid (2005)

The cyclic somatostatin analogue cyclo[Pro(1)-Phe(2)-D-Trp(3)-Lys(4)-Thr(5)-Phe(6)] (L-363,301) displays high biological activity in inhibiting the release of growth hormone, insulin, and glucagon. According to the sequence of L-363,301, we synthesized a number of cyclic hexa- and pentapeptides containing nonnatural alpha- and beta-amino acids. The N- fluorenylmethoxycarbonyl protected cyclic beta-amino acid [1S, 2S, 5R]-2-amino-3,5-dimethyl-2-cyclohex-3-enecarboxylic acid (cbetaAA), for the replacement of the Phe(6)-Pro(1) moiety of L-363,301, was synthesized in two steps by an enantioselective multicomponent reaction using (-)-8-phenylmenthol as a chiral auxiliary. The resulting peptide cyclo[cbetaAA(1)-Tyr(2)-D-Trp(3)-Nle(4)-Thr(Trt)(5)] (Trt = triphenylmethyl) shows high antiproliferative effects in an in vitro assay with A431 cancer cells. The same peptide without the Trt group does not reveal any biological activity, whereas L-363,301 and closely related hexapeptides show only minor activity. By comparison of the solution structure of cyclo[cbetaAA(1)-Tyr(2)-D-Trp(3)-Nle(4)-Thr(Trt)(5)] with the structure of l-363,301, a nearly perfect match of the betaII'-turn region with d-Trp in the i + 1 position was observed. The cyclic beta-amino acid cbetaAA is likely needed for the bioactive conformation of the peptide.
Covalent Protein Binding of a Minor Deramciclane Metabolite in Dog Plasma (1998)

The plasma protein interaction of a slowly eliminated substance which could be detected even after three weeks (about 0.2% of dose) in the plasma of Beagle dogs after a single oral administration of 10 mg kg−1 radiolabeled deramciclane, was determined.



The substance, which could not be removed by extraction or displacement, was a metabolite irreversibly bound to serum albumin. The covalent adduct formed during the first 24 h after treatment, reached a maximum concentration between 1 and 4 days, and had an elimination half-life of approximately 10 days. The metabolite was isolated and subjected to mass spectrometry, and identified as a deramciclane derivative having a carboxylate group on the camphor ring.