gebhart/patrepeval huggingface dataset:
Inherited disorders of the skin in human and mouse: from development to differentiation. (2004)

The last ten years has revealed some of the key players in the development and differentiation of the hair follicle and the epidermis in general. In this review, we discuss how our current understanding of these processes has been made possible by the elucidation of the molecular basis of human inherited diseases and mouse mutants which display defects in the hair and epidermis. For examples, the study of ectodermal dysplasias and the basal cell carcinoma predisposition disease Gorlin syndrome have allowed the determination of signalling hierarchies critical in the formation of the hair follicle. Epidermolytic diseases and hyperkeratoses have focussed attention on the importance of the programs of keratin expression, while ichthyoses provide insight in the final stage of epidermal development, cornification. Finally, the increasing range of diseases and mouse models exhibiting alopecias are revealing the critical pathways in control of the hair follicle cycle.
Evaluating the Constructability of NUDECK Precast Concrete Deck Panels for Kearney Bypass Project (2015)

Aerobic and anaerobic cultures and clinical data were obtained from 126 pediatric patients with acute conjunctivitis. Similar cultures were obtained from 66 persons who did not have a conjunctival inflammation. Anaerobes were isolated from 47 patients (37.3%). In 26 cases (20.6%), they were in mixed cultures with aerobes, and in 21 cases (16.7%), they were the only isolates. Aerobes alone were recovered in 72 patients (57.1%). No bacterial growth was noted in seven patients (5.6%). The organisms recovered from eyes with conjunctivitis in statistically significant numbers were Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and anaerobic Gram-postive cocci.
Adult multilocular cystic nephroma: Report of six cases with clinical, radio-pathologic correlation and review of literature (2013)

MCN is a benign cystic lesion and clinical presentations are nonspecific with symptoms such as abdominal pain, hematuria and urinary tract infection. These nonspecific clinical presentations and confusing radiological features create difficult preoperative differentiation from malignant cystic renal neoplasms.
ChemInform Abstract: SAEURE‐KATALYSIERTE UMLAGERUNG VON TRICYCLO(4,4,0,0(2,7))DECAN‐3‐OLEN (1972)

Abstract Die Umlagerung von 3,6‐Dimethyl‐tricyclodecan‐3‐ol (Ia) und dem Monomethylalkohol (Ib) in Gegenwart von Säuren wird im Zusammenhang mit Untersuchungen in der Reihe von Longifolen‐Naturstoffen untersucht.
Learning Dense Visual Correspondences in Simulation to Smooth and Fold Real Fabrics (2021)

Robotic fabric manipulation is challenging due to the infinite dimensional configuration space, self-occlusion, and complex dynamics of fabrics. There has been significant prior work on learning policies for specific fabric manipulation tasks, but comparatively less focus on algorithms which can perform many different tasks. We take a step towards this goal by learning point-pair correspondences across different fabric configurations in simulation. Then, given a single demonstration of a new task from an initial fabric configuration, these correspondences can be used to compute geometrically equivalent actions in a new fabric configuration. This makes it possible to define policies to robustly imitate a broad set of multi-step fabric smoothing and folding tasks. The resulting policies achieve 80.3% average task success rate across 10 fabric manipulation tasks on two different physical robotic systems. Results also suggest robustness to fabrics of various colors, sizes, and shapes. See https://tinyurl.com/fabric-descriptors for supplementary material and videos.
CUDA cuts: Fast graph cuts on the GPU (2008)

Graph cuts has become a powerful and popular optimization tool for energies defined over an MRF and have found applications in image segmentation, stereo vision, image restoration, etc. The maxflow/mincut algorithm to compute graph-cuts is computationally heavy. The best-reported implementation of graph cuts takes over 100 milliseconds even on images of size 640times480 and cannot be used for real-time applications or when iterated applications are needed. The commodity Graphics Processor Unit (GPU) has emerged as an economical and fast computation co-processor recently. In this paper, we present an implementation of the push-relabel algorithm for graph cuts on the GPU. We can perform over 60 graph cuts per second on 1024times1024 images and over 150 graph cuts per second on 640times480 images on an Nvidia 8800 GTX. The time for each complete graph-cut is about 1 millisecond when only a few weights change from the previous graph, as on dynamic graphs resulting from videos. The CUDA code with a well-defined interface can be downloaded for anyonepsilas use.
Plasma lipoprotein profiles of normocholesterolemic and hypercholesterolemic homozygotes for apolipoprotein E2(Arg158--&gt;Cys) compared (1994)

We compared plasma lipoprotein profiles of 15 individuals with normocholesterolemic (plasma cholesterol 4.81 +/- 0.90 mmol/L) familial dysbetalipoproteinemia (NFD) and 15 patients with hypercholesterolemic (plasma cholesterol 10.61 +/- 2.32 mmol/L) familial dysbetalipoproteinemia (HFD), matched for age and sex. All subjects were homozygous for apoE2(Arg158-->Cys). Compared with 15 normolipidemic controls (plasma cholesterol 5.47 +/- 0.92 mmol/L), subjects with NFD and HFD had greater cholesterol concentrations of large very-low-density lipoprotein (VLDL1), small VLDL (VLDL2), and intermediate-density lipoprotein, each of which was correlated to their plasma total cholesterol concentration. VLDL1 and VLDL2 subfractions were enriched in cholesteryl ester, and plasma cholesteryl ester transfer protein activities were increased in both NFD and HFD; however, absolute changes were larger in HFD than in NFD. Concentrations of low-density lipoprotein cholesterol were lower in HFD (1.89 +/- 0.48 mmol/L) and NFD (1.56 +/- 0.36 mmol/L) than in normolipidemic controls (3.35 +/- 0.73 mmol/L). We conclude that all subjects homozygous for apoE2(Arg158-->Cys) show features of dysbetalipoproteinemia.
Environmental noise characteristics of the MOD5-B (3.2 MW) wind turbine generator (1989)

Both narrow band and broad band acoustic data were obtained for the MOD5-B wind turbine for a range of wind speeds from 5.8 to 14.3 m/s; for a range of power outputs from 300 to 3100 kW; and for various azimuth angles and distances. Comparisons are made with those of other large machines and with predictions by available methods. The highest levels occur at the lower frequencies and generally decrease as the frequency increases. Low frequency rotational noise components were more intense than expected for an upwind machine and are believed to result from localized wind gradients across the rotor disk due to upwind terrain features. Predicted broad band spectra follow the general trends of the data but tend to underestimate the levels in the frequency range where the turbulent boundary layer-trailing edge interaction noise is expected to be significant.
The Effect of Amino Acids on Ouabain-Induced [45Ca]Calcium Ion Uptake into Slices of Rat Cerebral Cortex (1977)

Conference Article| August 01 1977 The Effect of Amino Acids on Ouabain-Induced [45Ca]Calcium Ion Uptake into Slices of Rat Cerebral Cortex DIETER R. RIDDALL; DIETER R. RIDDALL *Department of Pharmacology, Wellcome Research Laboratories, Langley Court, Beckenham, Kent, BK3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar ALAN N. DAVISON ALAN N. DAVISON †Department of Neurochemistry, Institute of Neurology, The National Hospital, Queen Square, London WC1N 3BG, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1977) 5 (4): 1075–1076. https://doi.org/10.1042/bst0051075 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation DIETER R. RIDDALL, ALAN N. DAVISON; The Effect of Amino Acids on Ouabain-Induced [45Ca]Calcium Ion Uptake into Slices of Rat Cerebral Cortex. Biochem Soc Trans 1 August 1977; 5 (4): 1075–1076. doi: https://doi.org/10.1042/bst0051075 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1977 Biochemical Society1977 Article PDF first page preview Close Modal You do not currently have access to this content.
Emergency Vehicle-Centered Traffic Signal Control in Intelligent Transportation Systems (2019)

The fast response of an emergency vehicle, such as an ambulance, fire engine, police vehicle, etc., is crucial to the protection of human life and property. With the steady increase of vehicles, the road intersection, a most congestion-prone zone, has become a great challenge to the emergency vehicle’s fast response despite its privilege of running a red light. To guarantee the safe, and fast pass of emergency vehicles stuck in congestion, an appropriate traffic signal control for emergency vehicle preemption is indispensable. In this work, we propose an emergency vehicle-centered traffic signal control, which focuses on the emergency vehicle’s performance, while minimising the negative impact on the traffic of conflicting directions. The proposed scheme can significantly decrease the emergency vehicle delay compared with the no preemption scheme (emergency vehicles have no priority), greatly reduce the impact on traffic of conflicting directions compared with the greedy preemption scheme (in which an emergency vehicle receives a green phase when it is detected to arrive at an intersection until it leaves), and notably lower the cost compared with the fuzzy logic-based scheme (which divides the real-time traffic conditions into several cases based on human knowledge and sets rules to control the signal accordingly).
A simple adaptive optimization scheme forIEEE 802.11 with differentiated channel access (2009)

This letter proposes an adaptive scheme to optimize the system throughput of IEEE 802.11 with differentiated channel access ability. Due to the difficulty of estimating the number of active stations and that approaches based on the estimation may not converge reported in previous research, the proposed scheme is developed to maximize the system throughput without the requirement of station number information while providing service differentiation among different traffic classes. Specially, the scheme is simple to implement and it only requires to measure the time the channel is in idle and collision states separately. Performance evaluation results show that the scheme is effective in achieving near to the theoretical maximum system throughput.
La FREEBANK : vers une base libre de corpus annotés (2004)

Colloque avec actes et comité de lecture. internationale.
Endometriosis: Diagnosis and Management (2010)

Objective To improve the understanding of endometriosis and to provide evidence-based guidelines for the diagnosis and management of endometriosis. Outcomes Outcomes evaluated include the impact of the medical and surgical management of endometriosis on women's experience of morbidity and infertility. Methods Members of the guideline committee were selected on the basis of individual expertise to represent a range of practical and academic experience in terms of both location in Canada and type of practice, as well as subspecialty expertise along with general gynaecology background. The committee reviewed all available evidence in the English and French medical literature and available data from a survey of Canadian women. Recommendations were established as consensus statements. The final document was reviewed and approved by the Executive and Council of the SOGC. Results This document provides a summary of up-to-date evidence regarding diagnosis, investigations, and medical and surgical management of endometriosis. The resulting recommendations may be adapted by individual health care workers when serving women with this condition. Conclusions Endometriosis is a common and sometimes debilitating condition for women of reproductive age. A multidisciplinary approach involving a combination of lifestyle modifications, medications, and allied health services should be used to limit the impact of this condition on activities of daily living and fertility. In some circumstances surgery is required to confirm the diagnosis and provide therapy to achieve the desired goal of pain relief or improved fecundity. Women who find an acceptable management strategy for this condition may have an improved quality of life or attain their goal of successful pregnancy. Evidence Medline and Cochrane databases were searched for articles in English and French on subjects related to endometriosis, pelvic pain, and infertility from January 1999 to October 2009 in order to prepare a Canadian consensus guideline on the management of endometriosis. Values The quality of evidence was rated with use of the criteria described by the Canadian Task Force on Preventive Health Care. Recommendations for practice were ranked according to the method described by the Task Force. See Table 1. Benefits, harms, and costs Implementation of the guideline recommendations will improve the care of women with pain and infertility associated with endometriosis.
Beta 1- and beta 2-adrenergic receptor expression in differentiating 3T3-L1 cells. Independent regulation at the level of mRNA. (1990)

Regulation of two highly homologous GTP-binding regulatory protein- (G-protein) linked receptors, beta 1- and beta 2-adrenergic receptors, was probed at the level of mRNA in differentiating 3T3-L1 cells. Expression of the two receptor subtypes at the protein level was defined by competition of radioligand binding with CGP-20712A, a highly selective beta 1-adrenergic antagonist. 3T3-L1 fibroblasts express equivalent levels of beta 1- and beta 2-adrenergic receptors. Following treatment with dexamethasone and isobutylmethyl xanthine (IBMX), 3T3-L1 cells differentiate to adipocytes and express 4-fold more receptor, predominantly beta 2-subtype (beta 1-/beta 2- ratio, 5:95). Regulation of beta 1- and beta 2-receptor mRNA levels by differentiation, as well as by steroid alone and IBMX alone was probed by DNA excess solution hybridization. A beta 1-receptor antisense probe was constructed from double-stranded DNA assembled from synthetic oligonucleotides. In untreated 3T3-L1 fibroblasts the steady-state levels of beta 1- and beta 2-adrenergic receptor mRNA were equivalent (approximately 1.2 amol mRNA/micrograms total cellular RNA). beta 2-Adrenergic receptor mRNA levels increased 3-fold as 3T3-L1 fibroblasts were differentiated to adiopcytes (day 7). mRNA levels for beta 1-adrenergic receptor, in contrast, increased at day 2, but thereafter declined, falling to less than 0.05 amol mRNA/micrograms total cellular RNA by day 7 in adipocytes. A 7-day challenge with dexamethasone reduced by 50% beta 1-adrenergic receptor mRNA levels. Treatment with IBMX alone reduced mRNA levels for both receptor subtypes. Neither steroid nor IBMX alone promoted differentiation. The present work, for the first time, demonstrates (i) the mRNA levels on a molar basis for two highly homologous G-protein-linked receptors expressed in a single cell, (ii) independent regulation of their mRNA levels that correlates well with receptor expression, and (iii), that it is differentiation in 3T3-L1 cells per se and not treatment with glucocorticoid or IBMX alone that promotes the up-regulation of the beta 2-receptor transcripts and down-regulation of beta 1-receptor transcripts.
Zero-ripple analysis methods for three-port bidirectional integrated magnetic &#x0106;uk converters (2014)

In this paper, the three-port Ćuk converter interfaces one unidirectional input power port (envisioned to be a DC power source such as PV, or fuel cell) and two bidirectional output ports, representing the grid-tied inverter dc bus and a storage port respectively, and combines all the magnetics into a single core. The well-known property of the basic Ćuk converter that emulates an ideal dc-dc transformer (zero ripple terminal currents) is extended to three ports and is analyzed in detail. Two methods, one involving the physical structure of the core, and the other, a circuit-based dual approach, which is directly related to the core structure, are applied to solve the zero-ripple problem, and the accuracy of one of them over the other is verified with simulation results. Three different power transfer modes in this three-port converter are compared using the two methods mentioned above.
Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation. (1993)

We have previously reported that LiCl increases considerably the cytotoxic activity of TNF towards some transformed cell lines such as L929. Here we show that treatment of these cell lines with the combination of TNF and LiCl leads to the prolonged accumulation of inositol monophosphate, inositol bisphosphate, and inositol trisphosphate, whereas treatment with TNF or LiCl alone did not. In contrast, both a LiCl-unresponsive TNF-sensitive cell line and TNF-resistant cell lines did not respond with increased accumulation of inositol phosphates (IPn) upon treatment with the combination of TNF and LiCl. Furthermore, the combination of TNF and LiCl induced a transient increase in cytidine diphosphate-diacylglycerol in L929 cells. Increased IPn and cytidine diphosphate-diacylglycerol accumulation preceded the onset of cell killing by approximately 1 h. TNF-mediated cytotoxicity and TNF-induced IPn accumulation were equally sensitive to inhibition by the phospholipase inhibitor neomycin and to stimulation by the protein kinase inhibitor staurosporine. Characterization of the inositol bisphosphate isomers by HPLC analysis revealed that the TNF + LiCl-induced increase in IPn levels was due to activation of a phospholipase C and not of a phospholipase D. In contrast to TNF, several other cytotoxic agents did not increase IPn production upon application in the presence of LiCl. The TNF + LiCl-induced increase in inositol triphosphate suggests a role for intracellular Ca2+ mobilization in TNF action. Moreover, several agents that lower the intracellular Ca2+ concentration inhibited TNF cytotoxicity. In conclusion, our data provide evidence that TNF cytotoxicity and its enhancement by LiCl are mediated by increased IPn accumulation resulting in Ca2+ mobilization.
DEHYDROEPIANDROSTERONE FAILS TO ENHANCE IMMUNE FUNCTION AFTER NON-THERMAL INJURY IN ELDERLY RATS (1995)

Brathwaite, Collin E.M.; McCoy, Philip J. Jr.; Seidel, Geoffrey; Young, Gary S.; Ross, Steven E. Author Information
Expression of the target receptor CD33 in CD34<sup>+</sup>/CD38<sup>−</sup>/CD123<sup>+</sup> AML stem cells (2006)

Leukaemic stem cells in patients with CD33(+) AML express CD33. This observation is in favour of novel treatment concepts employing CD33-targeting antibodies in AML.
Low-dose of Ionizing Radiation Enhances Cell Proliferation Via Transient ERK1/2 and p38 Activation in Normal Human Lung Fibroblasts (2007)

This study shows the human cellular responses and the mechanism of low-dose ionizing radiation in CCD 18 Lu cells, which are derived from normal human lung fibroblasts. Cell proliferation and viability assay were measured for the cells following gamma-irradiation using trypan blue, BrdU incorporation, and Wst-1 assay. We also examined genotoxicity using a micronuclei formation assay. The activation of the MAPKs pathway was determined by Western blot analysis, and the siRNA system was used to inhibit the expression of ERK1/2 and p38. We found that 0.05 Gy of ionizing radiation stimulated cell proliferation and did not change Micronuclei frequencies. In addition, 0.05 Gy of ionizing radiation activated ERK1/2 and p38, but did not activate JNK1/2 in cells. A specific ERK1/2 inhibitor, U0126, decreased the phosphorylation of ERK1/2 proteins induced by 0.05 Gy of ionizing radiation, and a similar suppressive effect was observed with a p38 inhibitor, PD169316. Suppression of ERK1/2 and p38 phosphorylation with these inhibitors decreased cell proliferation, which was stimulated by 0.05 Gy of ionizing radiation. Furthermore, downregulation of ERK1/2 and p38 expression using siRNA blocked the cell proliferation that had been increased by 0.05 Gy of ionizing radiation. These results suggest that 0.05 Gy of ionizing radiation enhances cell proliferation through the activation of ERK1/2 and p38 in normal human lung fibroblasts.
Analysis of Abused Drugs in Human Urine with Commercial Enzyme Immunoassay Reagents. (1996)

A simple, rapid and sensitive screening method and semiquantitative analysis for abused drugs, methamphetamine (MA), morphine (MO), cocaine (COC) and cannabinoid (CN), in the urine sample were investigated usine the Syva Emit stTM urine assay reagent with Shimadzu CL-770, the temperature-controlled spectrophotometer. A sample was diluted and mixed in an Emit stTM urine reagent vial with an Emit stTM dilutor. Thirty seconds after mixing, the mixture was transferred to the flow cell of the spectrophotometer kept at 37°C, and the absorbance change at 349 nm was measured for 30 s (60 s for CN). Calibration curves were examined over a range of 0 to 50 μg/ml for MA, morphine-3-glucuronide (M3G) and benzoylecgonine (BE), 0 to 0.5 μg/ml for Δ9-tetrahydrocannabinol-11-oic acid (THC-COOH), and were found to be relatively linear between 0 and 0.5 μg/ml for MA and M3G, 0 and 1 μg/ml for BE, 0 and 0.3 μg/ml for THC-COOH. Cutoff values were able to be set at the concentration of 0.5 μg/ml for MA, 0.5 μg/ml for M3G (corresponding to 0.2 μg/ml), 0.3 μg/ml for BE, 0.1 μg/ml for THC-COOH, and within-run coefficients of variation (C. V.) for the samples of the cutoff levels were less than 2% (n=10). The quantitative results from enzyme multiplied immunoassay technique (EMIT) assays for 100 urine samples were compared with those from GC, GC/MS and LC/MS, and the former showed an excellent correlation with the latter for MA and BE levels. Dihydrocodeine, however, showed a high cross-reactivity with MO, which often caused "false positive results."
Polymer–protein conjugates from ω-aldehyde endfunctional poly(N-vinylpyrrolidone) synthesised via xanthate-mediated living radical polymerisation (2008)

Aldehyde omega-endfunctional poly(N-vinylpyrrolidone) was synthesised via quantitative conversion of a xanthate endfunctional precursor obtained via RAFT-mediated polymerisation.
Magnetic circular dichroism of Na3Eu(ODA)3⋅2NaClO4⋅6H2O (1994)

Magnetic circular dichroism (MCD), circular dichroism (CD), and axial absorption spectra of Na3Eu(ODA)3⋅2NaClO4⋅6H2O are recorded at 4.2 and 150 K between 4500 and 25 500 cm−1. MCD parameters, rotatory strengths, and intensities are calculated using a parametric model for 4f→ 4f transitions. It is shown that the sign and magnitudes of the MCD parameters are very sensitive to the sign and absolute values of the intensity parameters.
Malignant lymphoma involving the jaw in African children: Treatment with methotrexate (1963)

A children was first recognized by one of us (D.B.)l as being but one manifestation of a generalized neoplastic disease. The clinical and geographical aspects,l-s radiology, and pathology7~ 8,121 l 3 have been described.