gebhart/patrepeval huggingface dataset:
Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity (1996)

This study examined the hypothesis that experimentally induced corticosteroid resistance in the brain would lead to adaptations in the activity of the hypothalamic-pituitary-adrenal (HPA) axis similar to the endocrine features of the endogenous resistance accompanying the pathogenesis of depression. For this purpose, the glucocorticoid antagonist RU 38486 (aGC) was infused intracerebroventricularly (i.c.v.) (100 ng/h) via Alzet minipumps for several days. During this chronic receptor blockade, parameters for basal and stress-induced HPA activity were measured in a longitudinal study design. Chronic i.c.v. infusion of the aGC did not affect basal morning levels of ACTH and corticosterone. During the afternoon phase of the circadian cycle, the aGC caused gradual and sequential changes in the HPA axis. After aGC infusion, the circadian rise of ACTH levels was enhanced in the afternoon of day 1, but was normal on subsequent days. For corticosterone, basal afternoon levels towards the diurnal peak were increased at days 1, 3, and 4 in aGC-treated rats. On day 2, in contrast, corticosterone levels did not differ from vehicle-infused controls. Paraventricular CRH messenger RNA, as measured at day 4, was not altered by aGC treatment. After 10 days of aGC treatment, the adrenal weight was increased, and the sensitivity of adrenocortical cells in vitro to ACTH was enhanced. Corticosteroid receptor binding in vitro in hippocampus, hypothalamus, and pituitary was not different between the aGC and vehicle-treated rats. In a second series of experiments, the HPA responsiveness to the stress of a novel environment at day 2 in the morning was increased after chronic aGC infusion, at a time basal hormone levels were not affected. The data show that 1) chronic i.c.v. infusion of aGC readily enhances the amplitude of circadian corticosterone changes, presumably by increasing the adrenocortical sensitivity to ACTH; 2) chronic aGC-treated animals show an enhanced ACTH and corticosterone response to stress, which is delayed in termination; 3) corticosteroid receptor expression, basal CRH messenger RNA, and ACTH levels are not altered after prolonged chronic aGC treatment. It is concluded that, over a period of a few days, aGC-induced corticosteroid resistance triggers a sequelae of pituitary-adrenal adaptations ultimately resulting in hypercorticism. Paradoxically, however, this hypercorticism develops because of increased peak levels of corticosteroid hormone rather than through elevated trough levels as is commonly observed during depressive illness.
Penetration, retention, intracellular localization, and antimicrobial activity of antibiotics within phagocytes. (1994)

The deficiency in cell-mediated immunity that is the hallmark of AIDS has led to a resurgence of infections with tubercle bacilli and other intracellular pathogens, and to renewed attention to the mechanisms by which antibiotics penetrate and are retained within phagocytic leukocytes. We review here recent studies of these mechanisms and the activity of different classes of antibiotics against microbial pathogens growing within or ingested by neutrophils and mononuclear phagocytes.
Lossless compression of instrumentation data. Final report (1995)

This is our final report on Sandia National Laboratories Laboratory- Directed Research and Development (LDRD) project 3517.070. Its purpose has been to investigate lossless compression of digital waveform and image data, particularly the types of instrumentation data generated and processed at Sandia Labs. The three-year project period ran from October 1992 through September 1995. This report begins with a descriptive overview of data compression, with and without loss, followed by a summary of the activities on the Sandia project, including research at several universities and the development of waveform compression software. Persons who participated in the project are also listed. The next part of the report contains a general discussion of the principles of lossless compression. Two basic compression stages, decorrelation and entropy coding, are described and discussed. An example of seismic data compression is included. Finally, there is a bibliography of published research. Taken together, the published papers contain the details of most of the work and accomplishments on the project. This final report is primarily an overview, without the technical details and results found in the publications listed in the bibliography.
Subchronic Dermal Toxicity and Oral Neurotoxicity of Triethylene Glycol Monomethyl Ether in Cd Rats (1998)

These studies were conducted to evaluate the potential for repeated subchronic administration of triethylene glycol monomethyl ether (TGME) to produce systemic toxicity in the rat following dermal application, and neurotoxicity in the rat following peroral administration. The route of administration and maximum dose levels for these studies were specified by the U.S. Environmental Protection Agency (EPA) in a testing consent order for TGME. In the subchronic dermal toxicity study, TGME (undiluted) was applied to the clipped backs of CD rats (10 rats/sex/group) for 6 h/day (occluded), 5 days/wk or 13 wk at dose levels of 0, 0.4, 1.2, and 4.0 g/kg/day. Four groups of satellite animals (5 rats/sex/group) employed for interim hematology and clinical chemistry measurements were dosed in the same manner for 31 days. Experimental evaluations included clinical examinations, food consumption, body weight, ophthalmology, estrous cyclicity, hematology, clinical chemistry, urinalysis, and necropsy for all animals and microscopic examination of a complete set of tissues (including bone marrow smears) for animals in the control and high-dose treatment groups. In addition, the testes and epididymides were processed for examination of spermatocyte development. None of the experimental endpoints included in this study to evaluate the potential for systemic toxicity were affected by treatment with TGME. For the neurotoxicity study, TGME was mixed in the drinking water and administered ad libitum to rats
Online Certificate Status Protocol-OCSP (1999)

This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the &quot;Internet Official Protocol Standards &quot; (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited. Copyright Notice Copyright (C) The Internet Society (1999). All Rights Reserved. This document specifies a protocol useful in determining the current status of a digital certificate without requiring CRLs. Additional mechanisms addressing PKIX operational requirements are specified in separate documents. An overview of the protocol is provided in section 2. Functional requirements are specified in section 4. Details of the protocol are in section 5. We cover security issues with the protocol in section 6. Appendix A defines OCSP over HTTP, appendix B accumulates ASN.1 syntactic elements and appendix C specifies the mime types for the messages.
Predictive and prognostic effect of CD133 and cancer-testis antigens in stage Ib-IIIA non-small cell lung cancer. (2015)

CD133 and cancer-testis antigens (CTAs) may be potential predicted markers of adjuvant chemotherapy or immune therapy, and they may be the independent prognostic factor of NSCLC. Nowadays, there is still no predictive biomarker identified for the use of adjuvant chemotherapy in non-small cell lung cancer (NSCLC) patients. To clarify the role of CD133 and CTAs as a predictive marker for adjuvant chemotherapy or prognostic factors of overall survival, we performed a retrospective study in 159 stage Ib-IIIA NSCLC patients receiving adjuvant chemotherapy or observe from April 2003 to March 2004 in our institute. Clinical data and gene anaylisis results were collected, while CD133 and three CTAs (MAGE-A4, NY-ESO-1, MAGE-A10) were determined according to their monoclonal antibodies such as CD133, 57B, D8.38 and 3GA11 by immunohistochemistry. All CTAs were more frequently expressed in squamous cell carcinoma (SCC) (50.0%, 26.9%, 34.6%) than in adenocarcinoma (16.2%, 16.2%, 16.2%). CD133 was more frequently found in patients with adenocarcinoma (P=0.044). Negative expression of CD133 was associated with a significantly longer overall survival compared to positive expression of CD133 (62.5 vs. 48.5 months, P=0.035). When combined with MAGEA4, NY-ESO-1or MAGE-A10, patients' OS showed significantly difference among different combination. (CD133-MAGEA4-/CD133-MAGEA4+/CD133+MAGEA4-/CD133+MAGEA4+: 65.6 months vs.51.5 months vs.32.2 months vs.19.8 months, P=0.000, CD133-NY-ESO-1-/ CD133+NY-ESO-1-/CD133-NY-ESO-1+/ CD133+NY-ESO-1+: 57.8 months vs. 55.7 months vs. 44.6 months vs. 28.5 months, P=0.000, CD133-MAGEA10-/CD133+ MAGEA10-/CD133-MAGEA10-/CD133+MAGEA10+: 66.2 months vs. 57.2 months vs. 48.8 months vs. 41.4 months, P=0.001). There is no difference between patients received adjuvant chemotherapy or not, but subgroup analysis showed that the patients with CD133+NY-ESO-1+ expression who received chemotherapy will survive longer than not receive adjuvant chemotherapy (received vs. not received, 52.1 vs. 27.1 months, P=0.020). In the subgroup with EGFR mutation/ALK translocation/Ros1 translocation/Ret fusion, the trend remained but without a statistically significant difference. Multivariate COX regression analysis showed that stage, CD133, CD133-MAGEA4- and CD133-NY-ESO-1- are independent prognostic factors. In conclusion, CTAs (MAGE-A4, NY-ESO-1, MAGE-A10) were more likely expressed in patients with squamous cell carcinoma and when CTAs combined with CD133, they can be better prognostic factors. Patients with CD133+NY-ESO-1+ expression may survive longer when treated with adjuvant chemotherapy, which indicates that the CD133 and CTAs might be a potential marker to guide adjuvant chemotherapy in this population.
Order statistics for decomposable combinatorial structures (1994)

Abstract In this paper we consider the component structure of decomposable combinatorial objects, both labeled and unlabeled, from a probabilistic point of view. In both cases we show that when the generating function for the components of a structure is a logarithmic function, then the joint distribution of the normalized order statistics of the component sizes of a random object of size n coverges to the Poisson–Dirichlet distribution on the simplex ∇{{ x i }: Σ x i = 1 x 1 ⩾ x 2 ⩾ …︁ ⩾ 0}. This result complements recent results obtained by Flajolet and Soria on the total number of components in a random combinatorial structure. © 1994 John Wiley & Sons, Inc.
Invisible signatures on images based on nonlinear dynamical systems (1995)

Keywords: Non-Linear Signal Processing ; Classification Reference LANOS-CONF-1995-016 Record created on 2004-12-03, modified on 2017-05-12
Voltammetric ion selective electrode for the determination of nitrate (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVoltammetric ion selective electrode for the determination of nitrateJames A. Cox and George R. LitwinskiCite this: Anal. Chem. 1979, 51, 4, 554–556Publication Date (Print):April 1, 1979Publication History Published online1 May 2002Published inissue 1 April 1979https://pubs.acs.org/doi/10.1021/ac50040a024https://doi.org/10.1021/ac50040a024research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
3D Flight Trajectory Playback System (2012)

QAR (Quick Access Recorder) is a widely used data-recording device to record a wealth of flight data. Flight data is widely applied in the field of flight quality assessment. QAR Data is pre-processed to get rid of abnormal data. Playback of Three-dimensional dynamic process is achieved by utilization of google earth based on .NET. So the pilot can clearly review the full three-dimensional flight procedure. It's helpful to correct their bad habits.
The contribution of mouse models to our understanding of systemic candidiasis (2011)

Some Candida species are common commensals, which can become opportunistic pathogens in susceptible hosts. In severely ill patients, Candida species, particularly Candida albicans, can cause life-threatening systemic infections. These infections are difficult to diagnose, as symptoms are similar to those of systemic bacterial infections. These difficulties can lead to delays in initiation in antifungal therapy, which contributes to the high mortality rates (> 40%) associated with these infections. In order to investigate systemic Candida infection, mouse models have been developed that mimic human disease, the most common being the intravenous infection model and the gastrointestinal colonization and dissemination model. This review discusses the two models and the contributions that they have made to our understanding of fungal virulence, host response to infection and the development of novel antifungal therapies and diagnostics.
A 3.3V lOGb/s SiGe Limiting Transimpedance Amplifier Using a Pseudo-Differential Input and a Limiting Cherry-Hooper Stage (2005)

A 10Gb/s Iimiting transimpedance amplifier was realized in a 0.2pm SiGe technology having a 60GHz transition frequency. A pseudo-differential common-emitter input stage with both capacitive and input hondwire inductive peaking was used to achieve high bandwidth and low noise performance. Cascode configurations and Miller capacitance neutralization techniques were used to minimize the input capacitance of the high current stages. This eliminates or reduces to one the number of inter-stage isolation emitter followers, and therefore allows a low voltage operation. The limiting amplifier uses a modified Cherry- Hooper architecture having a cross-coupled pair that speeds- up the switching and thus reduces its noise sensitivity.
The Role of Polysaccharides Derived from Medicinal Mushrooms in Cancer Treatment Programs: Current Perspectives (Review) (2003)

Mushroom-derived polysaccharides are now considered to be compounds that are able to modulate animal and human immune responses and to inhibit certain tumor growths. This review sets out the current information on the use of various mushroom polysaccharides in cancer treatments. Many human cancer cell lines have been studied, and in some cases direct cytotoxic effects have been demonstrated. Several mushroom polysaccharide compounds have proceeded through Phases I, II, and III clinical trials and are used extensively and successfully in Asia to treat various cancers. It is considered that such proprietary mushroom compounds will be seen mainly as complementary or adjunctive therapies to be used together with mainstream care therapies.
Programming as an evolutionary process (1976)

Programming is studied as an evolutionary process (starting with the problem description and ending with some computer program), which is done in a sequence of transformation steps. Nature of these steps at several levels is illustrated by typical examples. The aim is to arrive at a computer-surveyed, intuition-controlled programming support system (CIPS). Some aspects of this project, which is under way at the Technical University of Munich Informatics Institute, are discussed.
Recent advances in capillary electrophoresis coupled with chemiluminescence detection (2017)

摘要：
Proliferation, migration, matrix turnover, and death of smooth muscle cells in native coronary and vein graft atherosclerosis (1996)

Smooth muscle cells migrate into the vascular intima, proliferate, and lay down extracellular matrix, thereby forming an important component of the occlusive mass of atherosclerotic plaques in native arteries and in saphenous vein grafts. The viability of smooth muscle cells and the integrity of their surrounding extracellular matrix also determine the liability of plaques to rupture and hence precipitate myocardial infarction and vein graft occlusion. This update reviews recent developments in the molecular understanding of relevant aspects of smooth muscle cell biology. It highlights the increasing importance attached to interactions between growth factors and components of the extracellular matrix in regulating migration and proliferation and the new roles assigned to apoptosis in these cells. It illustrates, furthermore, how the application of the techniques of molecular biology is identifying new targets for conventional and gene therapy.
Dietary fatty acids and the risk of Parkinson disease (2005)

These findings suggest that high intake of unsaturated fatty acids might protect against Parkinson disease.
Extraction of Disease-Treatment Semantic Relations from Biomedical Sentences (2010)

This paper describes our study on identifying semantic relations that exist between diseases and treatments in biomedical sentences. We focus on three semantic relations: Cure, Prevent, and Side Effect. The contributions of this paper consists in the fact that better results are obtained compared to previous studies and the fact that our research settings allow the integration of biomedical and medical knowledge. We obtain 98.55 % F-measure for the Cure relation, 100 % F-measure for the Prevent relation, and 88.89 % F-measure for the Side Effect relation. 1
Competitive learning of network diagram layout (2002)

For applications which generate diagrammatic representations, automatic layout techniques are a crucial component. Since graph-like network diagrams are among the most commonly used and most important types of diagrammatic displays, layout techniques for graphs have been extensively studied. However a problem with current graph layout methods which are capable of producing satisfactory results for a wide range of graphs is that they often put an extremely high demand on computational resources. The paper introduces a new layout method that consumes only little computational resources and does not need any heavy duty preprocessing. Unlike other declarative layout algorithms, not even the costly repeated evaluation of an objective function is required. The method presented is based on a competitive learning algorithm which is an extension of self organization strategies known from unsupervised neural networks.
ChemInform Abstract: 2‐(2‐Furyl)‐ and 2‐(2‐Thienyl)‐5‐aryloxazoles. (1987)

Abstract Reaction of the aminomethyl aryl ketones (I) and the heterocyclic carboxylic chlorides (II) leads to the formation of the amides (III) which are cyclized with POCl 3 to give the title compounds (IV).
Where are general surgeons located in South Africa? (2018)

There was a major shortage of surgical providers in South Africa, and in particular the public sector.
SMART CARDS: DEBUNKING THE MYTHS (1997)

The ongoing and planned smart card demonstrations, such as the Washington Metro SmarTrip, are intriguing evidence that smart cards may be the technology of the future for transit fare collection. Yet many issues and doubts about smart cards remain, and need to be resolved before their use becomes widespread. This article will attempt to demystify smart card technology, and will describe why many who are pursuing smart card programs think that this technology will be an important part of transit operations in the future.
Bayesian Mapping of Multiple Quantitative Trait Loci From Incomplete Outbred Offspring Data (1999)

A general fine-scale Bayesian quantitative trait locus (QTL) mapping method for outcrossing species is presented. It is suitable for an analysis of complete and incomplete data from experimental designs of F2 families or backcrosses. The amount of genotyping of parents and grandparents is optional, as well as the assumption that the QTL alleles in the crossed lines are fixed. Grandparental origin indicators are used, but without forgetting the original genotype or allelic origin information. The method treats the number of QTL in the analyzed chromosome as a random variable and allows some QTL effects from other chromosomes to be taken into account in a composite interval mapping manner. A block-update of ordered genotypes (haplotypes) of the whole family is sampled once in each marker locus during every round of the Markov Chain Monte Carlo algorithm used in the numerical estimation. As a byproduct, the method gives the posterior distributions for linkage phases in the family and therefore it can also be used as a haplotyping algorithm. The Bayesian method is tested and compared with two frequentist methods using simulated data sets, considering two different parental crosses and three different levels of available parental information. The method is implemented as a software package and is freely available under the name Multimapper/outbred at URL http://www.rni.helsinki.fi/mjs/.
A new approach for solving extended unit commitment problem (1991)

An original approach is presented for solving the extended unit commitment problem using the Lagrangian relaxation method. The unit ramp rates have been incorporated into a dual optimization algorithm, making it possible to use the feasible direction method for primal problem solution. The mathematical model developed also includes transmission capacity limits, regulation reserve requirements of a prespecified group of units, transmission losses, and fuel constraints. Standard unit commitment constraints such as power balance equations, fast spinning reserve constraints, and all local constraints are also taken into account. A computational package has been developed and tested over a 48 h time horizon on a large power system with 100 thermal units. The promising performance of this package makes it suitable for EMS application.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Preparation of Laponite-Armored Polystyrene Particles by Pickering Emulsion Polymerization (2013)

Laponite-armored polystyrene (PS) particles were fabricated by Pickering emulsion polymerization. Emulsions of styrene dispersed in water were stabilized by hydrophobic modified Laponite nanodiscs. The properties of PS particles were investigated by TEM, SEM and DLS. The results show that these particles have narrow size distribution with diameter around 160 nm, which attributes to the improvable wettibility of modified Laponite stabilizer. TEM result proves that Laponite nanodiscs are on the surface of PS particles.
[State of the cerebral circulation according to radiocirculographic data in patients with diabetes mellitus]. (1975)

Cerebral circulation velocity was studied by the method of radiociruclography in patients (101) with various forms of diabetes mellitus. There was revealed a decrease in this velocity in the majority (2/3) of these patients. Early preclinical forms of affections of the vessels of the brain were revealed, and the degree of these changes was established. This method permitted to detect an association between a disturbed cerebral circulation and the most frequent complication occurring in patients with diabetes mellitus (atherosclerosis and microangiopathies).