gebhart/patrepeval huggingface dataset:
Constraint-Based Tiled Windows (1986)

Typical computer workstations employ window managers for creating, destroying, and arranging windows on the screen. Window managers generally follow either a desktop metaphor, allowing windows to overlap each other like sheets of paper on a desk, or they use a tiling model, arranging each window with a specific size and location that avoids overlap. Desktop models allow for the most layout freedom, but can be frustrating to use when dealing with a large number of windows that must all be visible at once. Tiling models guarantee that each window will be completely visible on the screen, but thus far have provided relatively poor mechanisms for controlling layout decisions. This article describes work in tiled window management featuring a constraint-based layout mechanism. With it the user can specify the appearance of individual windows and constrain relationships between windows, thus exercising necessary control over the tiling process. We discuss our constraint model and then detail an implementation approach that would make use of those constraints.
Stacking Vnodes: a progress report (1993)

People are dissatisfied with the file system services that come with their UNIX systems. They want to add new and better features. At present they have two choices: express their service as a user-level NFS server, or use the vnode/VFS interface to build at least part of it into the kernel. Although the vnode/VFS interface has been remarkably successful as a kernel structuring concept, it has failed to provide source portability between UNIX versions or even binary compatibility between releases of the same UNIX version. It has been obvious for some time that a redesign of the vnode/VFS interface that allowed file systems to be shipped as binary kernel modules that survive from release to release is needed. We describe a prototype kernel with a vnode/VFS interface that would allow this. It is based on earlier work on vnodes at Sun and at UCLA, but it replaces the stacking concept by a more strictly object-oriented concept of interposition.
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation (2006)

Histone acetyltransferases (HATs) regulate transcription, chromatin structure and DNA repair. Here, we utilized a novel HAT inhibitor, anacardic acid, to examine the role of HATs in the DNA damage response. Anacardic acid inhibits the Tip60 HAT in vitro, and blocks the Tip60-dependent activation of the ATM and DNA-PKcs protein kinases by DNA damage in vivo. Further, anacardic acid sensitizes human tumor cells to the cytotoxic effects of ionizing radiation. These results demonstrate a central role for HATs such as Tip60 in regulating the DNA damage response. HAT inhibitors provide a novel therapeutic approach for increasing the sensitivity of tumors to radiation therapy.
Acridine dimers: influence of the intercalating ring and of the linking‐chain nature on the equilibrium and kinetic DNA‐binding parameters (1989)

The rigidity of the linking chain of bifunctional intercalators in the ditercalinium series was shown to be critical for antitumor activity. In order to study the influence of the rigidity of the linking chain on the DNA-binding properties of DNA bifunctional intercalators, fluorescent 9-aminoacridine and 2-methoxy-6-chloro-9-aminoacridine analogues with chains of variable rigidity were synthesized. 1H-NMR studies show that the conformation of 9-aminoacridine dimers is almost independent of the nature of the linking chain. A strong self-stacking of the aromatic rings of the 2-methoxy-6-chloro-9-aminoacridine is observed for dimers with flexible chains but not for those with rigid chains. All the dimers having a linking chain long enough to bisintercalate in DNA according to the excluded site model are indeed bisintercalators. The kinetic association constant of all monomers and dimers for poly[d(A-T)].poly[d(A-T)] are in the same range (2-4 x 10(7) M-1 s-1). The large increase of DNA binding affinity observed for the dimers is always associated with the expected decrease of the dissociation rate constant. The effect of chain rigidity and pH on the calf thymus DNA binding of 9-aminoacridine and 2-methoxy-6-chloro-9-aminoacridine dimers is quite different. In the series of 9-aminoacridine the pKa of the dimers remains high and therefore no difference of DNA-binding affinity is observed between pH 5 and 7.4. The rigidity of the linking chain does not significantly alter the DNA-binding affinity. In the 2-methoxy-6-chloro-9-aminoacridine series, the pKa of all dimers became smaller than the physiological pH and a dramatic decrease of DNA-binding affinity is observed when the pH is increased from pH 5 to 7.4. This decrease appears significantly smaller for dimers with rigid chains. A similar dramatic decrease of binding affinity at pH 7.4 is not observed for poly[d(A-T)].poly[d(A-T)]. This factor makes these dimers strongly specific for the alternating polymer at pH 7.4.
Curriculum and Research (2019)

This chapter provides an examination of the relationship between research and curriculum. Examples of the knowledge gained from research examining if a curriculum works (its effectiveness) and how a curriculum works (its processes) are explained. Attention is provided as well to the gaps in the knowledge base generated by research. In regard to understanding how curriculum works, these are significant. These gaps are examined in relation to how curriculum and what is important within it are framed within research; how teachers and children as actors within curriculum have been examined within research; and how availability of outcome measures has impacted research questions and conclusions. A thesis of the chapter is that the gaps that exist are related in part to a lack of theorizing about these aspects of curriculum, both on the part of researchers and those who develop curriculum.
APPLICATION OF NEW DRUGS IN CHRONIC LYMPHOCYTIC LEUKEMIA (2010)

Over the last few years, several new agents have been under evaluation in preclinical studies as well as in early clinical trials, and have shown promise in treating CLL. These treatments include new monoclonal antibodies (mAbs), immunomodulating agents, novel purine nucleoside analogs, Bcl-2 inhibitors and other agents. The most promising are a new mAbs targeted CD20 molecule or CD23, anti-CD40 mAbs and anti-CD37 antibody. Oblimersen, flavopiridol, and lenalidomide are also being evaluated both in pre-clinical studies and in early clinical trials. However, available therapies are only partially efficient and there is an obvious need to develop better strategies and new, more specific and active drugs.
Content development as multimodal editing in the web 2.0 workplace (2017)

In this paper we argue that mobile, design, content, and social media technologies are fundamentally transforming the role of the content developer in the workplace away from the originator of content and toward the more agile and iterative role of multimodal editor. We present observations from over 100 hours of embedded workplace research shadowing nine different professional communicators to show the importance of viewing content development through the lens of multimodal editing as a way of describing the rapidly iterative, detailed, product-oriented kind of work happening within a variety of constraints (time, genre, technology, etc.). We suggest ways teachers and practitioners should consider shifting our assumptions about the writing/content development process and modifying how we prepare our students for this kind of work in the classroom.
Testing ASICs at-speed (1991)

At-speed test of ASICs is effective to detect delay faults, however, strobing is difficult because of process variations. In this paper two methodologies to generate at-speed test vectors are described. One is based on the comparison and merger of simulation traces obtained with different timing conditions. The other is a two-pass test approach.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
VEHICLE DETECTION AND COMPASS APPLICATIONS USING AMR MAGNETIC SENSORS (1999)

The earliest magnetic field detectors allowed navigation over trackless oceans by sensing the earth’s magnetic poles. Magnetic field sensing has vastly expanded as industry has adapted a variety of magnetic sensors to detect the presence, strength, or direction of magnetic fields not only from the earth, but also from permanent magnets, magnetized soft magnets, vehicle distur-bances, brain wave activity, and fields generated from electric currents. Magnetic sensors can measure these properties without physical contact and have become the eyes of many industrial and navigation control sys-tems. This paper will describe the current state of magnetic sensing within the earth’s field range and how these sensors are applied. Several applications will be presented for magnetic sensing in systems with em-phasis on vehicle detection and navigation based on magnetic fields.
Induction of Peripheral Tolerance by Intrathymic Inoculation of Soluble Alloantigens: Evidence for the Role of Host Antigen-Presenting Cells and Suppresser Cell Mechanism (1995)

Intrathymic (IT) inoculation of soluble alloantigens (Ag) obtained from 3 M KCl extracts of resting T-cells induces donor-specific tolerance to cardiac allografts and islet allografts. This study examined the cellular basis of induction of transplantation tolerance by IT injection of soluble Ag. Our results show that while IT inoculation of 2 mg soluble donor Ag on Day -7 relative to Lewis islet transplantation induced specific unresponsiveness to islet allografts (> 200 days) in naive diabetic recipients, IT inoculation of 2 mg soluble Ag on the same day as islet transplantation did not prolong islet allograft survival in the same Lewis-to-WF rat combination. To define the role of donor APCs in intrathymic tolerance, we showed that IT injection of an admixture of 1 x 10(4) donor DC and 2 mg soluble Ag caused acute islet graft rejection. In contrast, addition of 1 x 10(4) recipient-type DC to the IT inoculum did not prevent long-term graft survival. This finding suggests that while the presence of donor APCs in the inoculum does not appear necessary for IT-alloantigen to induce peripheral tolerance, presentation of the soluble Ag in the thymus is dependent on host APCs. This conclusion is supported by our in vitro MLR experiments which showed that in vivo WF-Ag-primed Lewis T-cells proliferated specifically to WF-soluble Ag and that the response was enhanced 14-fold by the addition of responder-type DC. Addition of anti-Lewis MHC class II mAb specifically blocked the alloresponse, thus suggesting that in vivo Ag-primed T-cells are capable of recognizing and proliferating in response to allopeptides presented by responder APCs. We also showed that adoptive transfer of syngeneic naive T-cells into unresponsive recipients failed to break tolerance to long-term surviving islet allografts. This finding suggests that tolerance in this model is not due to a lack of T help. On the other hand, the adoptive transfer of spleen cells, but not sera, from the unresponsive WF recipients bearing long-term (> 120 days) functioning Lewis islets resulted in prolonged survival of donor-type but not third-party islet allografts in secondary syngeneic hosts. Our data suggest that the tolerogenic effect of IT inoculation of soluble Ag is dependent on the indirect pathway of Ag presentation and clonal deletion of alloreactive T-cells in the thymus, while suppressor/regulatory mechanism may be involved in the maintenance of peripheral tolerance.
Supercritical fluid extraction of bioactive lipids from the microalga <b> <i>Nannochloropsis </i> </b> sp. (2005)

Marine microalgae are recognised as an important renewable source of bioactive lipids with a high proportion of polyunsaturated fatty acids (PUFA), which have been shown to be effective in preventing or treating several diseases. For the extraction of oil from microalgae, supercritical CO2 (ScCO2) is regarded with interest, being safer than hexane and offering a negligible environmental impact, a short extraction time and a high-quality final product. Whilst some experimental papers are available on the supercritical fluid extraction (SFE) of oil from microalgae, only limited information exists on the kinetics of the process. In such a contest, a mathematical model able to describe the kinetics of the SFE was applied to the recovery with ScCO2 of lipids from Nannochloropsis sp., a marine microalga commonly used in aquaculture and characterised by a lipid fraction with a high PUFA content. The aim of this paper was to examine the effect of operating conditions on the kinetics of the SFE, on process yields and on the fatty acid composition of lipid extracts.
Using neural dynamics to switch attention (2006)

We present a distributed and dynamic model of visual attention based on the continuum neural field theory that allows to sequentially focusing salient locations in an image. A working memory system ensures that the corresponding objects are only focused once, even if they are moving around, such that the visual search is efficient. The model has been implemented on a robotic platform in order to search for natural objects such as fruits.
Ocular Pain After Intravitreal Injection (2013)

Topical tetracaine and lidocaine provide similar anesthesia before IVI. Topical diclofenac does not seem to reduce pain scores after IVI.
Plasma concentrations and central nervous system effects of the new hypnotic agent zopiclone in patients with chronic liver disease. (1983)

Eight healthy individuals and seven cirrhotic patients received 7.5 mg zopiclone orally. Two further cirrhotics received 3.75 mg. Plasma concentrations of zopiclone and psychometric tests including reaction time and critical flicker fusion threshold and electroencephalographic tracings were performed at regular intervals after drug administration. Peak plasma levels of zopiclone were similar in the two groups but the time to peak was delayed in the cirrhotics. Plasma zopiclone half-life was 8.53 +/- 0.83 h in the cirrhotics and 3.50 +/- 0.33 h in the healthy individuals. In the group of cirrhotics there was a negative correlation between zopiclone half-life and serum albumin concentration (r = -0.87). Zopiclone caused sedation in both groups. Reaction time was prolonged and critical flicker fusion threshold reduced in both groups. Recovery was delayed in the cirrhotics compared to the healthy subjects but was complete by 8 h. The size of the changes was somewhat greater in the cirrhotics but baseline observations differed between the groups. The mean dominant frequency was lower in the cirrhotics and fell slightly in that group after zopiclone administration. The response to zopiclone is delayed and exaggerated in cirrhosis. Precautions are therefore required when using this drug in patients with chronic liver disease.
Simulation of a multistage fractured horizontal well in a tight oil reservoir using an embedded discrete fracture model (2019)

Abstract As an unconventional resource, tight oil reservoirs hold abundant geological reserves and great development potential. However, tight oil reservoirs suffer from high heterogeneity and low permeability. To obtain commercial oil and gas flow, multistage hydraulically fractured horizontal well technology is often adopted. In this paper, an embedded discrete fracture model ( EDFM ) is adopted to study the fractured reservoir. First, the relationship between the EDFM connection list is studied and its coefficient matrix of the equation system is solved. EDFM connection list is a method to record the connections between the grids. Thereafter, the reasons for the sparsity of the coefficient matrix and the symmetry of the locations of nonzero elements in the matrix are explained, and a simple method to establish and assemble the coefficient matrix is proposed. Using this method, a simulator for tight oil reservoir with EDFM is developed. By comparing the simulation results of the self‐programming simulator with the commercial software SAPHIR , the usefulness of the simulator is verified. Finally, several simulations and sensitivity analysis are performed to determine the key factors affecting production. Modeling studies show the influence of fractures, the horizontal well, and stress sensitivity, providing very useful information for the design of hydraulic fracturing and production development programs.
ENSEMBLE OF SOFTWARE DEFECT PREDICTORS: AN AHP-BASED EVALUATION METHOD (2011)

Classification algorithms that help to identify software defects or faults play a crucial role in software risk management. Experimental results have shown that ensemble of classifiers are often more accurate and robust to the effects of noisy data, and achieve lower average error rate than any of the constituent classifiers. However, inconsistencies exist in different studies and the performances of learning algorithms may vary using different performance measures and under different circumstances. Therefore, more research is needed to evaluate the performance of ensemble algorithms in software defect prediction. The goal of this paper is to assess the quality of ensemble methods in software defect prediction with the analytic hierarchy process (AHP), which is a multicriteria decision-making approach that prioritizes decision alternatives based on pairwise comparisons. Through the application of the AHP, this study compares experimentally the performance of several popular ensemble methods using 13 different performance metrics over 10 public-domain software defect datasets from the NASA Metrics Data Program (MDP) repository. The results indicate that ensemble methods can improve the classification results of software defect prediction in general and AdaBoost gives the best results. In addition, tree and rule based classifiers perform better in software defect prediction than other types of classifiers included in the experiment. In terms of single classifier, K-nearest-neighbor, C4.5, and Naïve Bayes tree ranked higher than other classifiers.
A method for accelerating the destruction of aircraft wake vortices (1998)

The wake vortices shed by large aircraft and their associated hazard to following aircraft remain an important issue in commercial aviation. Extensive research into methods for alleviating this wake vortex hazard has been continuing for many years. This paper presents results from numerical simulations detailing a potentially useful mechanism for accelerating the destruction of the aircraft vortex wake and reducing the wake vortex hazard. The term destruction is used to refer to the progressive annihilation of the wake caused by mixing of vorticity of opposite sign and the associated elimination of large coherent structures. The emphasis here is on a description of the mechanism and its connection to previous work
Hadamard Transform Photothermal Deflection Imaging (1986)

A 69-element Hadamard mask is used to encode a line-focused excimer laser beam to obtain spatially multiplexed photothermal deflection signals. The spatial distribution and relative quantities of potassium chromate samples on silica are recovered by Hadamard transformation.
Tandem-chamber charge density monitor (1990)

A device that is capable of measuring the charge density carried by an insulating fluid is described. The monitor relies on the principle of charge relaxation in two tandem chambers in such a way that the measurement is independent of residence and relaxation times. It is robust, has no moving parts, and is also able to monitor the conductivity of the fluid in applications for monitoring the streaming electrification in power transformers. Performance, accuracy, and applications of the device are outlined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
CORONAVIRUS DISEASE 2019 (COVID-19): A RHEUMATOLOGIST’S THOUGHTS (2020)

Система комплексной поддержки и сопровождения научного журнала Elpub позволяет запустить двуязычный сайт журнала со встроенной системой электронной редакции в соответствии с лучшими издательскими практиками, а так же предусматривает техническую и методическую поддержку со стороны специалистов НЭИКОН.
Theoretical studies of H2 desorption from Si(100)–2×1H (1993)

Theoretical studies of H2 desorption from a cluster model of the Si(100)–2×1H surface show that the desorption pathway is symmetrical and has a desorption energy barrier of 3.75 eV and a corresponding adsorption energy barrier of 1.15 eV. The proper treatment of electron correlation lowers the desorption energy barrier considerably. The present results suggest that the desorption of two hydrogen atoms from different Si atoms of a surface dimer is not the desorption pathway observed experimentally at activation energies in the range 2.0–2.9 eV.
Itraconazole versus terbinafine in the management of onychomycosis: an overview (2003)

Ever since the introduction of itraconazole and terbinafine in the management of onychomycosis, there has been a revival of interest in the latter. In order to comprehend the intricate emerging scenario, an endeavor has been made to form a distinct outline in the shape of an overview on several of their facets. The review, therefore, envisages forming and facilitating instant decision-making.
Des prénoms révolutionnaires en France (2000)

Les études sur les prénoms dits révolutionnaires apparaissent souvent comme monolithiques. L'essence du nom est plurielle et exige de porter un regard aigu sur ce tout ce qui entoure la nomination des individus et le nom même. La motivation du choix mais aussi du nom n'est pas unique. L'ambiguïté règne en maître et le nommant en use plus ou moins consciemment. Dès lors, c'est la définition du « prénom révolutionnaire » qui est remise en cause.
Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein (2015)

In a number of neurological diseases including Parkinson's disease (PD), α-synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and aggregation of α-synuclein in vivo. The toxicity of α-synuclein is popularly attributed to the formation of "toxic oligomers": a heterogenous and poorly characterized group of conformers that may share common molecular features. This review presents the available evidence on the properties of α-synuclein oligomers and the potential molecular mechanisms of their cellular disruption. Toxic α-synuclein oligomers may impact cells in a number of ways, including the disruption of membranes, mitochondrial depolarization, cytoskeleton changes, impairment of protein clearance pathways, and enhanced oxidative stress. We also examine the relationship between α-synuclein toxic oligomers and amyloid fibrils, in the light of recent studies that paint a more complex picture of α-synuclein toxicity. Finally, methods of studying and manipulating oligomers within cells are described.