gebhart/patrepeval huggingface dataset:
Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice (2018)

High levels of uranium (U) exist in soil, water, and air in the Southwestern United States due, in part, to waste generated from more than 160,000 abandoned hard rock mines located in this region. As a result, many people living in this region are chronically exposed to U at levels that have been linked to detrimental health outcomes. In an effort to establish a relevant in vivo mouse model for future U immunotoxicity studies, we evaluated the tissue distribution of U in immune organs; blood, bone marrow, spleen, and thymus, as well as femur bones, kidneys, and liver, following a 60-d drinking water exposure to uranyl acetate (UA) in male and female C57BL/6J mice. Following the 60-d exposure, there was low overall tissue retention of U (<0.01%) at both the 5 and the 50 ppm (mg/L) oral concentrations. In both male and female mice, there was limited U accumulation in immune organs. U only accumulated at low concentrations in the blood and bone marrow of male mice (0.6 and 16.8 ng/g, respectively). Consistent with previous reports, the predominant sites of U accumulation were the femur bones (350.1 and 399.0 ng/g, respectively) and kidneys (134.0 and 361.3 ng/g, respectively) of male and female mice. Findings from this study provide critical insights into the distribution and retention of U in lymphoid tissues following chronic drinking water exposure to U. This information will serve as a foundation for immunotoxicological assessments of U, alone and in combination with other metals.
The Ramberg—Baecklund Reaction for the Synthesis of C‐Glycosides, C‐Linked Disaccharides and Related Compounds (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Statistical Prediction of Maximum Time-Variant Inlet Distortion Levels (1975)

Abstract : Time-variant inlet pressure data from several aircraft designs are analyzed using tools based on Gumbel's extreme-value statistics with the results illustrating the basic randomness of distortion factors. A probabilistic model of distortion is proposed with three parameters to be evaluated by fitting to inlet data by the method of maximum likelihood. The effects of data acquisition time, frequency bandwidth, and sampling rate are discussed in context with Moore's similarity parameter to indicate scalability of the dynamic inlet distortion data.
Frequency keeping algorithm for atomic reference frequency and clock supply (1983)

Abstract A high‐accuracy cesium atomic oscillator is used as a clock for a digital communication network, in which, for instance, three cesium oscillators are used to take statistical average with the aid of a reference clock. We will discuss the algorithm for monitoring the frequency error by assuming a step frequency deviation. It has been confirmed that the algorithm satisfies the CCITT Time Interval Error requirements and that it switches to a normal cesium oscillator when frequency error is detected.
Scaled Modeling and Measurement for Studying Radio Wave Propagation in Tunnels (2020)

The subject of radio wave propagation in tunnels has gathered attention in recent years, mainly regarding the fading phenomena caused by internal reflections. Several methods have been suggested to describe the propagation inside a tunnel. This work is based on the ray tracing approach, which is useful for structures where the dimensions are orders of magnitude larger than the transmission wavelength. Using image theory, we utilized a multi-ray model to reveal non-dimensional parameters, enabling measurements in down-scaled experiments. We present the results of field experiments in a small concrete pedestrian tunnel with smooth walls for radio frequencies (RF) of 1, 2.4, and 10 GHz, as well as in a down-scaled model, for which millimeter waves (MMWs) were used, to demonstrate the roles of the frequency, polarization, tunnel dimensions, and dielectric properties on the wave propagation. The ray tracing method correlated well with the experimental results measured in the tunnel as well as in a scale model.
Abstract LB-345: Functional genomics reveals acute dependencies on polyadenylation for tumor cell mitotic progression (2010)

Abstract We are using genome-wide synthetic lethal paclitaxel chemosensitizer screens to understand the protein networks that support mitosis in lung tumor cells. Using this approach, we have identified several components of the polyadenylation machinery that are required for a high-fidelity mitosis in the presence of a synthetic lethal dose of paclitaxel. Here, we show depletion of multiple polyadenylation proteins in combination with low-dose paclitaxel causes a G2/M cell cycle block. We show depletion of one of these polyadenylation proteins, symplekin, has profound effects on mitotic spindle assembly resulting in over-duplicated centrosomes and impaired microtubule growth. Furthermore, we use a panel of lung lines to show symplekin is uniquely required for tumor cell mitosis as compared to normal cell mitosis. Our mechanistic studies suggest symplekin may mediate these effects on tumor cell mitosis by interacting with the centrosomally-associated protein transforming acidic coiled coil 3 protein (TACC3). Interestingly, TACC3 is typically expressed during development but becomes aberrantly upregulated in tumor cells. We propose TACC3 may become upregulated during tumorigenesis and engage symplekin to support mitosis in tumor cells. These results suggest polyadenylation components may represent an attractive therapeutic target in combination with already available anti-mitotic agents. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-345.
Optical nonlinearity in Hg<sub>0.84</sub>Cd<sub>0.16</sub>Te and Hg<sub>0.97</sub>Mn<sub>0.03</sub>Te (1988)

We have observed a third‐order nonlinear optical susceptibility of 1.5×10−3 esu in a Hg0.84Cd0.16Te epitaxial layer which has a small open band gap at 80 K. The relaxation time for the nonlinear effect is estimated to be 5 ps, and identified as the thermalization time of the electrons. The nonlinear mechanism is different from the band filling effect observed in larger band‐gap HgCdTe samples, as evidenced by the different intensity dependence of the nonlinearity.
A BDD-based algorithm for reliability analysis of phased-mission systems (1999)

This paper presents a new algorithm (PMS-BDD) based on the binary decision diagram (BDD) for reliability analysis of phased-mission systems (PMS). PMS-BDD uses phase algebra to deal with the dependence across the phases, and a new BDD operation to incorporate the phase algebra. Due to the nature of the BDD, cancellation of common components among the phases can be combined with the BDD generation, without additional operations; and the sum of disjoint products (SDP) can be implicitly represented by the final BDD. Several examples and experiments show that PMS-BDD is more efficient than the algorithm based on SDP, in both computation time and storage space; this efficiency allows the study of some practical, large phased-mission systems.
Persistence of enterohaemorrhagic and nonpathogenic<i>E. coli</i>on spinach leaves and in rhizosphere soil (2009)

The persistence of nonpathogenic E. coli isolates makes them possible candidates as surrogates for E. coli O157:H7 on spinach leaves in field trials.
Synthesis of the Pyridine Core of Cyclothiazomycin (2011)

A highly convergent synthesis of the pyridine core of the thiopeptide antibiotic cyclothiazomycin has been developed based on a [2+2+2] cyclotrimerization key step. The regioselective assembly of the heterocyclic center of this important class of antibiotics takes advantage of a temporary silicon tether and the ruthenium-catalyzed cyclotrimerization reaction of a diyne and an electron-poor thiazole nitrile.
A benzo-fused oxapenem from a β-lactam-4-ylidene (1998)

Spiro-fused β -lactam oxadiazoline 2a was prepared from acetone semicarbazone in five steps. Thermolysis of 2a at 100°C in benzene led to carbene 3a, which cyclized to the benzo-fused oxapenem derivative 4 via intramolecular OH insertion. Compound 10, with a β -lactam ring linked to an azetidinedione ring, was a minor product.Key words: benzoxapenem, carbene, β -lactam-4-ylidene, OH insertion.
Low stereoselectivity in methylacetylene and cyclopropene reductions by nitrogenase. (1979)

The stereochemistry of reductions catalyzed by nitrogenase in 2H2O has been investigated by using allene, methylacetylene, and cyclopropene as substrates. Deuterium labeling patterns in the reduction products were determined by mass spectroscopy, infrared spectroscopy, 2H-decoupled 220-MHz 1H NMR, and 1H-decoupled 30.7-MHz 2H NMR. Reduction of allene gave pure [2,3-2H2]propene. Reduction of methyl acetylene gave a 1.8:1.0 mixture of [cis- and [trans-1,2-2H2]propene. (Similar reduction of acetylene reportedly gave virtually all [cis-1,2-2H2]ethylene.) Reduction of cyclopropene gave [cis-1,2-2H2]cyclopropane and a mixture of [2H2]propenes. The major propene 2H2 isomers formed were [trans-1,3-2H2]-propene (approximately 2), [cis-1,3-2H2]propene (approximately 1) and [2,3-2H2]propene (approximately 1). Cyclopropene appears to be unique as a nitrogenase substrate in that it simultaneously undergoes parallel reductions, one of which proceeds with high stereoselectivity while the other proceeds with low stereoselectivity. The weakly selective stereochemistry observed in these reductions is not consistent with a completely concerted dual proton-dual electron transfer mechanism. The results provide a basis to probe stereochemical effects in nitrogenase and in biomimetic model systems.
[Granulomatous lobular mastitis: a clinicopathologic study of 68 cases]. (2010)

GLM shows clinical and radiologic features reminiscent of breast cancer. Correct diagnosis requires histologic examination of the biopsy specimens.
Characteristics of Ion-Induced Bending Phenomenon (2010)

We propose a technique of bending thin films based on the ion-induced bending (IIB) phenomenon that allows the fabrication of three-dimensional device structures and arrays, such as devices for micro-electromechanical systems (MEMSs). We investigated the IIB characteristics with various types of thin films under various ion irradiation conditions. We found that the important parameters of the IIB phenomenon were the depth of ion irradiation and ion dose. We also found that bending curvature could be controlled by the normalized depth of ion implantation and the dose of ions. Microsized regions of vertically standing thin-film arrays that were tens of nanometers thick could be produced with this technique.
HIV‐1 Tat inhibits NGF‐Induced Egr‐1 transcriptional activity and consequent p35 expression in neural cells (2008)

Infection with HIV-1 causes degeneration of neurons leading to motor and cognitive dysfunction in AIDS patients. One of the key viral regulatory proteins, Tat, which is released by infected cells, can be taken up by various uninfected cells including neurons and by dysregulating several biological events induces cell injury and death. In earlier studies, we demonstrated that treatment of neuronal cells with Tat affects the nerve growth factor (NGF) signaling pathway involving MAPK/ERK. Here we demonstrate that a decrease in the level of Egr-1, one of the targets for MAPK, by Tat has a negative impact on the level of p35 expression in NGF-treated neural cells. Further, we demonstrate a reduced level of Egr-1 association with the p35 promoter sequence in NGF-treated cells expressing Tat. As p35, by associating with Cdk5, phosphorylates several neuronal proteins including neurofilaments and plays a role in neuronal differentiation and survival, we examined kinase activity of p35 complexes obtained from cells expressing Tat. Results from H1 kinase assays showed reduced activity of the p35 complex from Tat-expressing cells in comparison to that from control cells. Accordingly, the level of phosphorylated neurofilaments was diminished in Tat-expressing cells. Similarly, treatment of PC12 cells with Tat protein or supernatant from HIV-1 infected cells decreased kinase activity of p35 in these cells. These observations ascribe a role for Tat in altering p35 expression and its activity that affects phosphorylation of proteins involved in neuronal cell survival.
Transfert de gènes par des vecteurs rétroviraux aviaires dérivés de l'AEV ES4 (Avian Erythroblastosis virus) : rôle de la position du gène inséré et de son contexte traductionnel sur l'efficacité des vecteurs (1988)

Le virus de l'erythroblastose aviaire (aev es4) est un virus defectif leucenogene comportant deux oncogenes v-erba et v-erbb. Construction de vecteurs retroviraus derives du genone de l'aev. Les retrovirus recombinants recoltes ont servi a infecter des fibroblastes d'embryon de poulet (cef) ou des fibroblastes immortalises de caille (qtg). Construction de vecteurs a double expression genique, regulation de l'epissage
The effect of microbial phytase and myo-inositol on performance and blood biochemistry of broiler chickens fed wheat/corn-based diets (2013)

A total of 1,200 Ross broiler chickens were used in 2 separate feeding studies to explore the effect of myo-inositol (MYO) and phytase on performance and blood biochemistry of broilers fed diets formulated to be either adequate or insufficient in Ca and digestible P (dP). Supplementation of diets that were formulated to be insufficient in Ca and dP with MYO resulted in improved BW gain and feed conversion ratio in both experiments. However, these effects were most pronounced in the finisher phase, and moderate negative effects were observed during the starter period. Supplementation of the diet with microbial phytase improved BW gain and feed conversion ratio to a similar extent as was observed with MYO, and there was a degree of subadditivity between the 2 additives. Blood glucose concentrations were increased by both MYO and phytase, though possibly by different mechanisms, because insulin concentrations were not directly relatable to circulating glucose levels, especially when both MYO and phytase were applied simultaneously. The increase in blood glucose concentrations with MYO and phytase was most pronounced in the diet with a lower Ca and dP concentration. It can be concluded that dietary supplementation with MYO or phytase was effective in improving performance of commercial broiler chickens. However, further work is required to explore complex ontogenetic effects of MYO and possible involvement of both MYO and phytase in Na-dependent transport mechanisms.
Erythromycin Inhibition of Lipopolysaccharide-Stimulated Tumor Necrosis Factor Alpha Production by Human Monocytes in Vitro (1992)

The mechanism of clinical effectiveness of low-dose and long-term erythromycin (EM) treatment for diffuse panbronchiolitis, sinobronchial syndrome, and associated otitis media with effusion was investigated by studying the effects of EM on tumor necrosis factor alpha (TNF-alpha) production by cultured human monocytes stimulated with lipopolysaccharide. At concentrations of 0.1 microgram/mL or more, EM inhibited TNF-alpha release from human monocytes stimulated by lipopolysaccharide in a dose-dependent manner. Of the other macrolides tested, roxithromycin, an EM derivative, also showed significant inhibition of TNF-alpha production, whereas josamycin failed to inhibit TNF-alpha release from monocytes. Nonmacrolidic drugs such as minocycline hydrochloride, ofloxacin, or penicillin G had no significant effect on TNF-alpha production. These results suggest that the clinical improvement of chronic respiratory diseases by EM may depend on the suppression of production of inflammatory cytokines such as TNF-alpha.
Systemic Candidiasis (2000)

Despite the widespread use of amphotericin B and azote antifungal agents, hematogenously disseminated infections caused by Candida species are a serious problem in hospitalized patients. Candida species continue to be the fourth most common cause of nosocomial septicemia, accounting for 5% to 10% of all nosocomial bloodstream infections. This incidence of candidemia surpasses the incidence of bacteremia caused by Escherechia coli or Klebsiella species. Furthermore, Candida species are the most common cause of deep-seated fungal infections in patients who have extensive burns or who have undergone orthotopic liver or bone marrow transplantation. In many cases, an indwelling vascular catheter is considered to be the portal of entry. In fact, Candida species are the third most common cause of catheter-related infections, causing 11% of these infections.
THE HYDROBORATION OF REPRESENTATIVE CROTYL(2-BUTENYL) DERIVATIVES AND RELATED STRUCTURES (1966)

Abstract not available
The Collagen-Binding Protein Cnm Is Required for Streptococcus mutans Adherence to and Intracellular Invasion of Human Coronary Artery Endothelial Cells (2011)

Streptococcus mutans is considered the primary etiologic agent of dental caries, a global health problem that affects 60 to 90% of the population, and a leading causative agent of infective endocarditis. It can be divided into four different serotypes (c, e, f, and k), with serotype c strains being the most common in the oral cavity. In this study, we demonstrate that in addition to OMZ175 and B14, three other strains (NCTC11060, LM7, and OM50E) of the less prevalent serotypes e and f are able to invade primary human coronary artery endothelial cells (HCAEC). Invasive strains were also significantly more virulent than noninvasive strains in the Galleria mellonella (greater wax worm) model of systemic disease. Interestingly, the invasive strains carried an additional gene, cnm, which was previously shown to bind to collagen and laminin in vitro. Inactivation of cnm rendered the organisms unable to invade HCAEC and attenuated their virulence in G. mellonella. Notably, the cnm knockout strains did not adhere to HCAEC as efficiently as the parental strains did, indicating that the loss of the invasion phenotype observed for the mutants was linked to an adhesion defect. Comparisons of the invasive strains and their respective cnm mutants did not support a correlation between biofilm formation and invasion. Thus, Cnm is required for S. mutans invasion of endothelial cells and possibly represents an important virulence factor of S. mutans that may contribute to cardiovascular infections and pathologies.
La récupération des matières plastiquesexpérience dans les Pays ScandinavesTraduit de l'anglais par M. FROELICH.Cerclez n° 4 (1978)

Le recyclage des déchets de matières plastiques, en provenance aussi bien d’installations de production que d’ordures ménagères, a été discuté et étudié ces dernières années dans les pays Scandinaves. Il s’agit là, pour une part, d’un problème économique ayant trait à l’utilisation correcte des matières premières, et, pour une part, d'un problème de destruction des ordures de la société.
Amplitude Space Sharing among the Macro-Cell and Small-Cell Users (2012)

The crushing demand for wireless data services will soon exceed the capability of the current homogeneous cellular architecture. An emerging solution is to overlay small-cell networks with the macro-cell networks. In this paper, we propose an amplitude space sharing (ASS) method among the macro-cell user and small-cell users. By transmit layer design and data-rate optimization, the signals and interferences are promised to be separable at each receiver and the network sum-rate is maximized. The Han-Koboyashi coding is employed and optimal power allocation is derived for the one small-cell scenario, and a simple ASS transmission scheme is developed for the multiple small-cells scenarios. Simulation results show great superiority over other interference management schemes.
Surgical Treatment vs Nonsurgical Treatment for Brain Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia: A Retrospective Multicenter Consortium Study (2017)

HHT patients treated surgically for brain AVMs appear to have long-term functional outcomes comparable to nonsurgical (including observational) therapy with fewer unfavorable outcomes. It is therefore reasonable to consider surgical resection as a management option in the multidisciplinary team's individualized treatment strategy for HHT patients with brain AVMs.
Use of ACM in Rehabilitation Projects in Egypt (2003)

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A Novel EPE Aware Hybrid Global Route Planner after Floorplanning (2016)

IC fabrication in nanometer technology nodes faces severe challenges in handling lithography hotspots due to edge placement error (EPE). These hotspots are particularly tackled by wire-spreading or rip-up and reroute during detailed routing, at the cost of more design iterations. They cannot be minimized unless a suitable routing penalty is imposed during global routing. In this paper, we present a new hybrid global route planning framework that follows floor planning. Since an accurate estimation of EPE on a net segment cannot be attained, we employ a routing penalty based on known simulation results, in order to identify a least cost routing path of a net across multiple metal layers. The results of our experiments on IBM HB floor planning benchmarks show an 4%, 53% and 74% improvement in net length, via count and worst case congestion respectively on an average.
Abstract 3483: The African-specific S47 variant of the p53 tumor suppressor gene alters cell metabolism (2019)

Abstract The TP53 gene, often referred to as the guardian of the genome, is the most frequently mutated gene in human cancer. This gene encodes the tumor suppressor p53, a master regulator of various processes such as programmed cell death, growth arrest and senescence. However, there is increasing evidence that highlights the role of p53 in tumor suppression with regards to maintaining metabolic homeostasis. Our lab has identified a polymorphic variant of p53 that encodes a serine residue instead of a proline at amino acid 47 (hereafter S47). This variant is most prevalent in African and African-American individuals, and mice and humans carrying this variant have increased cancer risk and impaired response to therapy. Using both mouse models and human cells, we have found that S47 cells have significantly altered metabolism compared to the WT counterpart. Specifically, S47 mice have increased weight and increased lean content compared to WT mice. These mice also show increased fitness in treadmill studies. Analyses of cell metabolism in S47 murine and human cells indicate that S47 cells show increased glycolysis and glycolytic flux, along with increased oxygen consumption rate on a Seahorse analyzer. The combined data support the premise that the S47 variant confers increased cancer risk but also increased metabolic fitness; the latter may explain the high rate of this variant in certain regions of Africa. By clearly elucidating the roles of WT p53 and the S47 variant in the context of metabolism, we hope to uncover new therapeutic avenues and ultimately enable more personalized medicine approaches for individuals who carry this variant. Citation Format: Keerthana Gnanapradeepan, Subhasree Basu, Che-Pei Kung, Thibaut Barnoud, Madeline Good, William Quinn, Joyce Lee, Kathryn Wellen, Zachary Schug, Joseph Baur, Donna George, Maureen Murphy. The African-specific S47 variant of the p53 tumor suppressor gene alters cell metabolism [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3483.