gebhart/patrepeval huggingface dataset:
Unrelated donor lymphocyte infusions as a treatment of immunodeficiency in complete DI George syndrome (2006)

Complete DiGeorge syndrome (DGS) is a rare congenital disorder characterized by number of developmental defects and T-cell deficiency. We present an infant with multiple anomalies (choanal and esophageal atresia, coloboma, tracheobronchomalacia, etc.), diagnosed at the age of 2 months with complete DGS (absence of T cells, no response to mitogens, absent thymus), treated with unrelated donor lymphocyte infusion (DLI). During first 7 months of age he required long-term ventilation, suffered recurrent infections, and sepsis. He had no sibling and no fully matched unrelated donor was available. At the age of 6 months the first dose of DLI (1 × 106 /kg CD3+; 2 ×105/kg CD34+) was administered to him from an unrelated donor (mismatched for B and Cw alleles) with no conditioning regimen and no graft versus host disease (GVHD) prophylaxis. Ten days after DLI, he developed severe acute GVHD (skin stage 3–4) complicated with sepsis, cardiopulmonary instability, capillary leak syndrome, and ileus. He was treated with antithymocyte globulin (rATG), cyclosporin A (CsA), and steroids with a complete resolution of GVHD. On day +36 after first DL, he was given the second DLI (0.9 × 106/kg CD3+) with no conditioning and GVHD prophylaxis consisting of continued CsA. EBV infection has appeared 4 weeks after infusion (peripheral expansion of CD8+ donor cells started), successfully treated with CsA withdrawal and rituximab. Isolated cholestatic liver GVHD manifested month after second DLI, progressed to stage 4, successfully treated with steroids, CsA, and rATG. Since day +10 after first DLI, the donor genotype due to presence of donor T cells is documented in VNTR. Response to mitogens appeared and is now comparable to healthy controls. Central memory (CD27pos, CD45RAneg) stages dominate in the peripheral blood CD4 and CD8 cells (64 to 81% and 52 to 95%, respectively), which was higher than in control. Effector memory cells are increased in CD4 subset, decreased in CD8. Naive CD4 T cells (CD45RApos, CD27pos) continued to be completely absent at all time-point measured, but naive CD8 (CD45RApos, CD27pos) were detected already at D +100 at 5% and continued raise thereafter. The patient is now 10 months after first DLI still on CsA and steroids, slowly started to gain his developmental milestones. We believe that infusions of small doses of DLI from an unrelated donor represent an adequate therapy for complete DiGeorge syndrome.
Spiral Structure and Star Formation. I. Formation Mechanisms and Mean Free Paths (1983)

The wide variety of optical appearances observed in spiral galaxies has encouraged the growth of two theoretical approaches to explain the spiral patterns exhibited by such young objects as OB associations, giant H II regions, and dark dust lanes. These approaches are related to the density wave theory of spiral structure and 'stochastic, self-propagating star formation'. Levinson and Roberts (1981) tried to reconcile these two theoretical approaches, and considered a disk filled with discrete gas clouds. The present investigation is concerned with refinements and extensions of the model of Levinson and Roberts. Attention is given to gravitational forces and dynamical propagation, cloud-cloud collisions, supernova interactions, computational models, a theory concerning the interactions of the gas cloud and stellar association systems, the time evolution of the gas cloud-stellar association systems, and aspects of collisionally triggered star formation.
Photonic crystal nanocavities toward low-power on-chip nanophotonic devices (2011)

Photonic crystal nanocavities are expected to greatly reduce the size and energy consumption of various optical devices. We have demonstrated this feature in all-optical switches, random access memories, and nanolasers for on-chip nanophotonic integration.
BAGHOUSE OPTIMIZATION AT A MEDICAL WASTE INCINERATOR (2001)

Phoenix Services, Inc., owns and operates the Baltimore Regional Medical Waste Incinerator in Baltimore, Maryland, USA. New regulations for dioxins and furans imposed emission limits considerably below historical emission levels. Therefore, the company had to consider available technologies for dioxin/furan control. After tri- als with different technologies, Phoenix Services, Inc., decided to replace their woven fiberglass filter bags with expanded polytetrafluoroethylene (ePTFE) membrane catalytic filters. This new membrane/catalytic filter system collects fine particulate matter on the surface and destroys dioxins and furans in the gas stream. This catalytic filter system offered several key advantages to Phoenix Services, Inc.: 1) destruction of dioxins and furans instead of adsorption on a catalyst surface; 2) no dioxin-filled residue to dispose of; 3) a passive system requiring minimal operating and maintenance attention; 4) no new capital equipment; and 5) a minimal learning curve. Although Phoenix Services was getting superior PCDD/F reduction with the new membrane/catalytic filters, the supplier of the new filters wanted to optimize the system to make it as cost effective as possible. The system economics were based on an expected filter life of five years, so bags were removed for analysis on a periodic basis to assure this goal would be met. It was also expected that by adjusting the cleaning system, the amount of absorbent material used for acid gas scrubbing would be reduced. While the filter replacement cost represented a significant expenditure at some future date, the scrubbing agent was by far the largest variable expense in the oper- ating budget. After installation of the ePTFE/catalytic filter system in June 1999, and upon recommendation by the supplier, Phoenix Services refurbished the filter bag cleaning system of the baghouse. This was completed in September 1999. It was immediately noted that the membrane filter media operated with different ∆ P characteristics than the glass bags. By October there was a dramatic reduction in scrubbing agent consumption. It became apparent that the reduc- tion was due to decreased filter bag cleaning. The results showed a reduction of more than 20% in adsorbent use. Further analysis was performed to determine the effect of waste composition on these results. Four years of data were investigated to confirm changes in scrubbing agent consumption. Even though the plastic (high chlorine) fraction of waste continued to increase, there was about a 33% reduction in adsorbent cost. The company saved over $100,000 in the first year of operation and reduced PCDD/F emissions by an order of magnitude, well within the new regulatory limits. This paper discusses the actual step-by-step optimization process. The procedures could be useful for process/maintenance/production engineers and/or managers for a Municipal Solid Waste, as well as Medical Waste, Incinerator facility. This paper is aimed at providing actual data from the plant, giving a factual view of new products and their benefits to the plant.
Klingsors letzter Sommer and the Transformation of Crisis (2013)

Klingsor’s letzter Sommer is part of a new kind of fiction that occupied Hermann Hesse immediately after the First World War. Along with Siddhartha and the lesser known Klein and Wagner, this brilliant novella explores the inner life through a correspondingly subjective language. These three works form a sequence: they appeared individually in the aftermath of the war and were re-published in 1931, as a collection called Weg nach Innen (The Way Within or The Inward Way), a title that pinpoints Hesse’s intention precisely. Hesse took this title from a fragment in Novalis’s collection called Blütenstaub: “Nach Innen geht der geheimnisvolle Weg” (Inward leads the secret way). Siddhartha projects a transformation of an individual life caught within a larger world of Buddhist and Taoist religions, while Klein und Wagner portrays an actual change in identity, a “Jekyll and Hyde” syndrome, as yet another aspect of a self transforming itself. In Klingsors letzter Sommer the famous painter Klingsor recreates himself in art as well as in death.
LOW LEVEL LASER THERAPY (LLLT) FOR CEREBRAL PALSY (2008)

Spasticity in cerebral palsy (CP) patients is a critical factor preventing voluntary movement, and can also be associated with involuntary clonus. Low reactive-level laser therapy (LLLT) has been reported as having good overall efficacy in CP patients and also in controlling clonus. The present study was designed to evaluate LLLT in the clinical setting to attenuate spasticity in severely handicapped CP patients. We treated 20 CP patients with near infrared (830 nm) LLLT (16.2J/cm2/point, once/week over 10 weeks) as a clinical study at our university hospital and a hospital connected with our university. For spasticity of the hip adductor muscle, the obturator nerve was the target for LLLT, and the tibial nerve was irradiated in the case of triceps surae muscle spasticity. LLLT was indicated for the 10 sessions and the degree of attenuation of spasticity was assessed after the final session. Some degree of efficacy and treatment latency was seen in 14 (70%) of the 20 patients, 5 evaluated as excellent, 6 as very good and 3 as fair. Little or no change was seen in the remaining 6 patients, and in no patient did the symptoms worsen. We concluded that LLLT was an efficacious treatment option in the conservative treatment of CP patients, that it was easilyapplied, non-invasive and pain-free, and that it did not have any adverse side effects.
Strukturmodifizierung von Polyethylen durch plasmagepfropfte Acrylsäuregruppen (1997)

Abstract Die Plasmatechnologie eröffnet neue effiziente Möglichkeiten für eine gezielt Struktur‐ und Eigenschaftsmodifizierung von Kunststoffen. In der vorliegenden Arbeit werden Untersuchungen zur Anwendung der Plasmapolymerisation für die Modifizierung von Polyethylen vorgestellt. Bei der Plasmapolymerisation wird organischer Dampf mit Hilfe des Plasmas aktiviert. Die dabei erzeugten Radikale und Ionen werden auf der Oberfläche des PE‐Pulver, das dem Plasma ausgesetzt ist, absorbiert und gehen eine feste Bindung ein. Dadurch entstehen funktionelle Gruppen auf der Oberfläche des PE‐Pulvers. Am Beispiel der Plasmapolymerisation mit Acrylsäure werden die erzielten Ergebnisse der Strukturmodifizierung von LDPE‐Pulver vorgestellt.
Time/frequency coding for Brillouin distributed sensors (2012)

In this paper, we propose a novel coding for long range Brillouin Optical Time Analysis (BOTDA) distributed sensors based on a combination of time and frequency pulses, resulting in an additional coding gain of √2 with respect to traditional intensity-modulated codes. The generation of frequency-chirped pseudo-arbitrary pulses in return-to-zero (RZ) format with a Direct-Digital Synthesizer (DDS) is presented and the coding gain is experimentally verified, perfectly matching its theoretical value.
Vapor phase carbonylation of organic compound over supported transition metal catalysts. V. Vapor-phase carbonylation of dimethyl ether on supported nickel catalyst. (1988)

活性炭担持ニッケル触媒を用いて気相,加圧下にてヨウ化メチル共存下でジメチルエーテルのカルボニル化反応を行なったところ酢酸メチルが選択性よく得られた。ニッケルの担持量の増加にともない酢酸メチルの収率は増加したが,2.5wt%以上で一定となった。これは金属の分散度の低下のためと考えられた。カルボニル化反応の一次生成物は酢酸メチルで,接触時間の増加とともに酢酸が生成し,また若干のメタンが見られた。これらの副生にはジメチルエーテルの分解により生じた水素あるいは水が関与している。また,さらにカルボニル化が進行し無水酢酸が生成することが確認された。反応温度,圧力が高いほど酢酸メチルの収率は高かったが選択性が低下した。これに対し,CO/DME,MeI/DME比を高くすると選択性の低下なしに酢酸メチル収率を高くすることが可能であった。各種リアクタント分圧に対する反応速度依存性を測定したところ,CO分圧に0.5次,ジメチルエーテルに1.0次,ヨウ化メチルに0.5次であった。メタノールのカルボニル化反応にくらべヨウ化メチル依存性が高いことが特徴的であり,その吸着過程が遅いことが示された。その原因は反応が無水系であるためで,水の添加により総括の反応速度が向上することが示された。
New approach to the hygienic standards of laser radiation in the visible spectral range (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Yu. D. Berezin, B. G. Malinin, N. Yu. Mal'kova, S. A. Novikov, V. I. Pirozhkov, and I. N. Ushkova, "New approach to the hygienic standards of laser radiation in the visible spectral range," J. Opt. Technol. 66, 121- (1999) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
MmWave meshed network with traffic and energy management mechanism (2017)

mmWave meshed network is a promising architecture for cost-efficient wireless backhaul of millimeter-wave overlay heterogeneous network (mmWave overlay HetNet). As user distribution in practice is time-variant and spatially non-uniform, mmWave meshed backhaul should be controlled adaptively. This paper proposes a novel method to control mmWave meshed backhaul for efficient operation of mmWave overlay HetNet in dynamic crowd scenario e.g. event venues. Our algorithm is featured by two functionalities, i.e. backhauling route multiplexing for overloaded mmWave small cell base stations (SC-BSs) and mmWave SC-BSs' ON/OFF status switching for underloaded spot. Considering practical user distribution modeled from realistic measurement data, radio backhaul resources should be concentrated on overloaded mmWave SC-BSs. Inversely, underloaded mmWave SC-BSs should be deactivated for saving power. The performance of mmWave meshed backhaul controlled by the proposed algorithm is evaluated by system level simulation. Numerical results show that the proposed algorithm can cope with the locally intensive traffic and reduce energy consumption.
Clinical significance of occult cerebrospinal fluid involvement assessed by flow cytometry in non‐Hodgkin’s lymphoma patients at high risk of central nervous system disease in the rituximab era (2010)

The presence of occult CNS involvement at diagnosis in patients with NHL at high risk of CNS disease is associated with a higher probability of CNS relapse.
A study of familial lupus erythematosus-likes disease and hereditary angio-oedema treated with danazol (1983)

Immunological and genetic studies were performed in a family in which the mother and five siblings had hereditary angio-oedema (HAE). LE cells, antinuclear factors, antibodies to double-stranded DNA and positive direct Coombs' test were not found in any of the subjects. One female sibling had a lupus erythematosus-like illness with skin lesions of the face which responded to danazol treatment. Laboratory evidence of HAE was obtained in the entire kindred and all the siblings shared HLA haplotype AIB7 inherited from the deceased mother.
Renal sodium retention in cirrhotic rats depends on glucocorticoid-mediated activation of mineralocorticoid receptor due to decreased renal 11β-HSD-2 activity (2006)

Downregulation of the renal glucocorticoid-metabolizing enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD-2) during liver cirrhosis may allow activation of the mineralocorticoid receptor (MR) by glucocorticoids and contribute to sodium retention. We tested this hypothesis in male Wistar rats with decompensated liver cirrhosis and ascites 7 wk after bile duct ligation (BDL). Renal 11beta-HSD-2 mRNA, protein, and activity were significantly decreased in decompensated rats. The urinary Na(+)/K(+) ratio was reduced by 40%. Renal epithelial sodium channel (ENaC) mRNA and immunostaining were only slightly affected. Complete metabolic studies, including fecal excretion, showed that the BDL rats had avid renal sodium retention. Treatment of the BDL rats with dexamethasone suppressed endogenous glucocorticoid production, normalized total sodium balance and renal sodium excretion, and reduced ascites formation to the same degree as direct inhibition of MR with K-canrenoate. Total potassium balance was negative in the BDL rats, whereas renal potassium excretion was unchanged. In the distal colon, expression of ENaC was increased in BDL rats. Fecal potassium excretion was increased in cirrhotic rats, and this was corrected by treatment with K-canrenoate but not dexamethasone. We conclude that development of sodium retention and decompensation in cirrhotic rats is associated with downregulation of renal 11beta-HSD-2 activity and inappropriate activation of renal sodium reabsorption by endogenous glucocorticoids. In addition, the overall potassium loss in the BDL model is due to increased fecal potassium excretion, which is associated with upregulation of ENaC in distal colon.
Immunological Characterization and Transmembrane Topology of 5‐Hydroxytryptamine<sub>3</sub> Receptors by Functional Epitope Tagging (1996)

5-Hydroxytryptamine3 (5-HT3) receptors are the only known monoamine receptors mediating fast excitatory responses in mammalian neurons. Their primary structure as well as their electrophysiological and pharmacological properties show a phylogenetic relation to nicotinic acetylcholine, GABAA, and glycine receptors. As a prototypical member of this gene superfamily, we investigated the membrane topology of functional homomeric 5-HT3 receptors by using epitope tagging of the channel subunits expressed in heterologous systems. Visualization of 5-HT3 receptors in transfected COS-7 cells, either in western blot (molecular mass 61.2 +/- 0.8 kDa) or in situ, was performed with previously characterized antibodies recognizing artificial epitopes as well as with anti-fusion protein antibodies directed against a wild-type receptor intracellular domain. The extracellular location of the distal C-terminal tagged domain demonstrates the presence of a fourth transmembrane domain in 5-HT3 serotonin-gated channels. In this region, the significant homology between members of this class of neurotransmitter-gated channels suggests strongly that they have a common transmembrane organization basically different from glutamate-gated and ATP-gated channels.
Reducing human exposure to solar ultraviolet radiation (1997)

Methods for reducing human exposure to solar ultraviolet radiation may not provide the expected degree of reduction in exposures with resultant undesirable effects which could be harmful. This paper examines the use of strategies for campaigns against skin cancer. It was shown that outdoor activities conducted before 10:00am or after 3:00pm may reduce the exposure by about 50%. The choice of UV-protective clothing should look for fabrics with high weight and compact weaving. Hats with a brim size up to 12cm could reduce the exposure to less than 10% of the ambient radiation on the forehead only. The protection of the hat for the lower part of the face is negligible (less than 10% reduction in exposure). A flat shade-structure reduces the exposure to about 30% of the natural ambient radiation at a height equal to the smallest dimension of the shade-cloth. In a greenhouse, the shoulder of a gardener could receive a cumulative exposure of 17 MED over a fortnight if he works 2 hours per day, for 5 days in a week. A well planned strategy using a combination of protective methods can minimize the level of exposure to harmful solar radiation.
A shock-induced phase change in orthoclase (1973)

New shock compression data to 340 kb for single-crystal orthoclase (along (001)) demonstrate the onset of a shock-induced phase change at ~115 kb. Along the Hugoniot a mixedphase region extends to ~300 kb, above which the data are believed to correspond to the properties of a high-pressure phase having the hollanditc structure (zero pressure density of 3.84 g/cm ) reported by Ringwood et al. If the hollanditc value for the zero pressure density is used, the zero pressure bulk modulus of this phase is approximately 2.8 q-0.2 Mb. The very high pressure equation of state of orthoclase is of importance both in describing the effects of intense shock waves on potassiumfeldspar-bearing rocks on the earth and the moon [Hubbard et al., 1971; Drake et al., 1970; Chao, 1967; Kleeraan, 1971; yon Engelhardt and Stoffier, 1968] and in studying the earth's mantle. The latter is important because the orthoclase structure provides a model of the response of feldspar-bearing rocks to the high pressures of the earth's interior. Previously reported Hugoniot data for microcline [Ahre.ns et al., 1969a] demonstrated that this mineral, like plagioclase [McQueen et al., 1967], begins to transform to a new phase or phases at about 120 kb (along the Hugoniot). This phase change appears to go to completion for shock states above ~300 kb. Above this level the limited Hugoniot data for microcline suggested that the properties of a denser high-pressure phase were being sampled. The zero pressure density for the high-pressure phase inferred by Ahrens et al. [1969b] and Davies and Anderson [1971] of ~3.5 g/cm ' compares unfavorably and inconclusively with densities of 3.2 and 3.84 g/cm expected for the possible high-pressure phases in the structures jadeitc plus stishovite and hollanditc. Because previous static high-pressure quenching experiments on both silicate and germanate (analog) potassium feldspar
ANTICUERPOS MATERNOS FRENTE AL VIRUS DE LA PESTE PORCINA CLÁSICA EN CRIAS DE CERDAS INMUNIZADAS CON CANDIDATO VACUNAL DE SUBUNIDAD PROTEICA (E2) (2011)

Con el objetivo de determinar la duracion de la inmunidad pasiva en cerdos procedentes de madres inmunizadas con un candidato vacunal de subunidad proteica E2 contra el virus de la peste porcina clasica (VPPC) y con la vacuna viva atenuada de la cepa China (LABIOFAM), se inmunizaron seis cochinatas seronegativas al VPPC con el candidato vacunal de subunidad proteica E2 y seis cerdas con antecedentes de tres inmunizaciones como minimo con la vacuna viva atenuada de la Cepa China lapinizada y tiempo maximo de 6 meses transcurridos desde la ultima aplicacion con la propia vacuna viva atenuada de la Cepa China. La primera dosis del candidato vacunal se aplico despues de la deteccion del celo y la segunda dosis 21 dias despues, mientras que se aplico una dosis de la vacuna viva atenuada de la Cepa China una semana antes de la cubricion. Se conformaron dos grupos con los cerdos procedentes de las madres inmunizadas con una y otra vacuna respectivamente. Se determinaron los titulos de anticuerpos maternos neutralizantes desde la segunda hasta la octava semana de edad. Los cerdos procedentes de madres inmunizadas con el candidato vacunal de subunidad proteica E2 mostraron titulos de anticuerpos maternos significativamente superiores durante el periodo evaluado con duracion de los titulos protectivos hasta las 8 semanas de edad. En los cerdos procedentes de madres inmunizadas con la vacuna viva atenuada se observaron titulos de anticuerpos maternos protectivos hasta la segunda semana de edad.
A 246 GHz Hetero-Integrated Frequency Source in InP-on-BiCMOS Technology (2014)

A 246 GHz source in InP-on-BiCMOS technology is presented. It consists of a voltage controlled oscillator (VCO) in BiCMOS technology and a frequency tripler in transferred-substrate InP-HBT technology, which is integrated on top of the BiCMOS MMIC in a wafer-level bonding process. The VCO operates at 82 GHz with 6 dBm output power and the combined circuit delivers -10 dBm at 246 GHz, with a phase noise of -87 dBc/Hz at 2 MHz offset. To the knowledge of the authors, this is the first hetero-integrated signal source in this frequency range reported so far. The results illustrate the potential of the hetero integrated process for sub-mm-wave frequencies.