gebhart/patrepeval huggingface dataset:
Prediction of Glide Avalanche Based on Composite Roughness (1998)

Abstract Surface topography of a magnetic disk is one of the key parameters to determine safe fly height in a hard disk drive. In order to quantify the flying capability of the disk surface, glide avalanche is a useful parameter because it is the parameter which indicates the height of the surface topography from the mean surface below which a head can not fly without contacts. The avalanche is regarded as the floor of the disk surface intrinsically defined by the surface finish during disk production. The glide height is set at higher level than the avalanche and usually limited by isolated defects or contamination on the surface. Because of this direct couple between glide avalanche and the disk surface finish, the measurement and prediction of the glide avalanche are very important. In this paper, we discuss the importance of fly height characterization of a glide head and the relationship between disk surface topography and its avalanche. We propose a simple yet versatile model based on a composite roughness, which can be applied to a polished surface and to a textured contact start/stop zone including laser bumps.
Relationship between SLCO1B1 521T>C genovariation and severe toxicity during high-dose methotrexate chemotherapy (2015)

Objective
To investigate the relationship between severe toxicity during high-dose methotrexate (HD-MTX) chemotherapy and 29 related factors including SLCO1B1 521T>C genovariation, and to enhance drug safety.


Methods
Eighty-two children with acute lymphoblastic leukemia (ALL) received HD-MTX chemotherapy.The regimen was MTX 3-5 g/m2 continuous infusion for 24 hours.The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect the patients' genotypes of SLCO1B1 T521C polymorphism, which was the coding gene of organic anion transporting polypeptide 1B1 (OATP1B1). Haematological, gastrointestinal and hepatic toxicities in 1-10 days after HD-MTX administration were observed and graded according to Common Terminology Criteria for Adverse Events (CTCAE, version 4.02). The patients were divided into two groups based on toxicity grades: case group (grades Ⅲ-Ⅴ) and normal group (grades 0-Ⅱ). The differences of 29 variates including biology features, biochemical indicators, SLCO1B1 T521C polymorphism and etc.were compared between the two groups by univariate analysis, and the significant factors were found out.The final predictive model of severe HD-MTX-related toxicity was set up through Logistic regression analysis.Receiver operating characteristic (ROC) curve of predictor was drawn based on final model in order to evaluate its predictive ability.


Results
There were only 4 significant different variates between case group and normal group (P C genovariation (odds ratio 18.489, 95% confidence interval 5.413-63.157) was the significant independent predictor for severe HD-MTX-related toxicity.The area under ROC (95% confidence interval) of SLCO1B1 521T>C genovariation as the predictor for severe HD-MTX-related toxicity was 0.776 (0.653-0.899), which had significant diagnositic value(P<0.05).


Conclusions
There is higher risk of severe HD-MTX-related toxicity while patients having SLCO1B1 521T>C genovariation.Clinician should consider it and take some protective measures.


Key words: 
Acute lymphoblastic leukemia; Methotrexate; Severe toxicity; Organic anion transporting polypeptide; Gene polymorphism
Investigation of the effect of magnetic retention systems used in prostheses on buccal mucosal blood flow. (1992)

The purpose of this study was to investigate the probable effects of the magnetic field produced by dental magnets on neighboring capillary circulation. Ten subjects were used. Transparent acrylic resin devices were prepared to receive the dental magnets and were used continually by subjects except during sleep. The maxillary buccal mucosal blood flow was measured on both sides (control and experimental) in the same subjects before the use of dental magnets and after 3, 7, 15, 30, and 45 days by the 133Xe clearance technique. Upon analysis it was found that the difference in blood flow between the control and experimental sides was insignificant (P greater than .05). The decrease in blood flow as time progressed was attributed to the pressure exerted by the oral devices rather than by the effect of the magnetic field.
An Authorization Scheme Concealing Client's Access from Authentication Server (2016)

OAuth 2.0 and OpenID Connect are widely used authorization frameworks in the development of web applications. However, there are privacy concerns when using these frameworks because an authentication server can easily identify the URI of a website being accessed by a client. In this study, we proposed and implemented an authorization scheme that allows a client to conceal a URI from an authentication server when a web service detects the client's request.
Some New Bounds on the Generalization Error of Combined Classifiers (2000)

In this paper we develop the method of bounding the generalization error of a classifier in terms of its margin distribution which was introduced in the recent papers of Bartlett and Schapire, Freund, Bartlett and Lee. The theory of Gaussian and empirical processes allow us to prove the margin type inequalities for the most general functional classes, the complexity of the class being measured via the so called Gaussian complexity functions. As a simple application of our results, we obtain the bounds of Schapire, Freund, Bartlett and Lee for the generalization error of boosting. We also substantially improve the results of Bartlett on bounding the generalization error of neural networks in terms of l 1 norms of the weights of neurons. Furthermore, under additional assumptions on the complexity of the class of hypotheses we provide some tighter bounds, which in the case of boosting improve the results of Schapire, Freund, Bartlett and Lee.
On-line heart beat recognition using hermite polynomials and neuro-fuzzy network (2003)

This paper presents a neuro-fuzzy approach to the recognition and classification of heart rhythms on the basis of ECG waveforms. The important part in recognition fulfills the Hermite characterization of the QRS complexes. The Hermite coefficients serve as the features of the process. These features are applied to a fuzzy neural network for recognition. The results of numerical experiments have confirmed very good performance of such a solution.
Itraconazole disposition after single oral and intravenous and multiple oral dosing in healthy cats (1997)

The oral itraconazole solution is preferred to capsules; a 24-hour dosing interval should be sufficient; 10 mg/kg given daily should generate therapeutic concentrations in most cats; steady-state concentrations may take up to 3 weeks to achieve; and cats appear to tolerate itraconazole well.
Characterization of the interaction between VP8 of bovine rotavirus C486 and cellular components on MA-104 cells and erythrocytes. (1998)

Rotavirus VP8*, the N-terminal trypsin cleavage product of VP4, has been shown to bind to MA-104 cells and human O type erythrocytes. To examine whether bacterially expressed VP8* binds to cellular components of MA-104 cells, the VP8* (aa 1-247) was expressed in E. coli and radiolabelled with 35S-methionine. The radiolabelled rVP8* was immunoprecipitated with antiserum to bovine rotavirus C486 (BRV). The rVP8* was found to bind to MA-104 cells and its binding was competed by BRV. To study the interaction between VP8* and receptors of erythrocytes, hemagglutination (HA) and hemagglutination inhibition (HI) assays were carried out using solubilized rVP8*. rVP8* showed HA which could be inhibited by antiserum to BRV. This interaction was also inhibited by gangliosides, demonstrating a sialic acid dependent interaction. To study the contribution of the C-terminal region of VP8* to HA, a number of approaches were used. First, a peptide spanning aa 230-247 was synthesized and antisera was raised against the peptide to see whether it could inhibit HA of rVP8*. Second, a truncated form of VP8* (tVP8*: aa 1-229) was expressed to examine its hemagglutinating activity. Third, the dimerization of rVP8* and tVP8* was compared by Western-blotting following electrophoresis using native SDS-PAGE. The results indicated that antibody to aa 230-247 inhibits hemagglutination by preventing dimerization of VP8* which in turn allows the molecule to cause HA. To characterize the interaction between the HA domain and sialic acid receptors, erythrocytes were treated with sialidases of different specificities. Arthrobacter ureafaciens, Clostridium perfringens and alpha 2-8 linkage-specific neuraminidase destroyed the ability of sialic acid of erythrocytes to interact with rVP8*, indicating that bovine rotavirus C486 binding requires an alpha 2-8 linkage but acetylation of the sialic acid is not necessary.
Cloud Based Pos with Online Purchase (2017)

This project aims to get a user friendly approach in customer and gives more advantage to vendor. Here we are developing a website to purchase and sell the product from a shop. POS (Point of sale), a current running technology used for more efficient interaction with vendor and shop keeper. Inventory software programs now on the market let us track usage, monitor changes in unit dollar costs, calculate when we need to reorder, and analyze inventory levels on an item-by-item basis. We can even control inventory right at the cash register with point-of-sale (POS) software systems. POS software records each sale when it happens, so our inventory records are always up-to-date. Better still, we get much more information about the sale than we could gather with a manual system. By running reports based on this information, we can make better decisions about ordering and merchandising. Our POS system is much more advanced. These are setup with software that can link to other networks. They can therefore store endless data about stock and clients-instantly and electronically. POS system offers a variety of positives to the business manager or director; let's first explore the advantages it offers to the main system's user (i.e. employees) who would be having direct contact with the system and customer each day. Other advantages include ability to implement various types of discounts, a loyalty scheme for customers and more efficient stock control.
THE EFFICACY AND SAFETY OF TELMISARTAN COMPARED TO ENALAPRIL IN PATIENTS WITH SEVERE HYPERTENSION (1999)

This 8-week, open-label study compared the efficacy and safety of once-daily telmisartan, either alone or in combination with hydrochlorothiazide (HCTZ) and amlodipine, with a similar enalapril regimen in patients with severe hypertension. Clinically relevant reductions in supine systolic blood pressure/DBP were observed with telmisartan (14.6/13.2 mmHg) and enalapril (13.0/12.9 mmHg) monotherapy. Incremental reductions were seen with up-titration of monotherapy (telmisartan 8.1/7.4 and enalapril 9.2/7.7 mmHg), and the addition of HCTZ (telmisartan 14.9/8.7 and enalapril 8.0/6.7 mmHg), and amlodipine (telmisartan 8.0/6.5 and enalapril 10.5/6.4). After 8 weeks of treatment, supine DBP control was achieved in 55% and 35% of the patients on the telmisartan and enalapril regimens, respectively. Both treatment regimens were well tolerated. Telmisartan, a new angiotensin receptor blocker, is a safe and effective drug to use in combination for the treatment of patients with severe hypertension and proved at least as effective as the enalapril combination.
Identification and stability of a new bichalcone in Achyrocline satureioides spray dried powder. (2010)

A new chemical structure, the 4,2',4",2'''-tetrahydroxy-6',6'''-dimethoxy-4'-O-4'''- bichalcone, named achyrobichalcone was isolated and identified from an Achyrocline satureioides spray-dried powder (SDP80). The thermal and photo stability of this new compound as well as that of the main polyphenols present in the spray dried powder, quercetin, luteolin, 3-O-metylquercetin and the corresponding kinetics of degradation are reported. In the long-term testing (30 +/- 2 degrees C/75 +/- 5% RH, 12 months), the total polyphenols contained in SDP80 demonstrated to be stable, remaining higher than 90% after a 12 month exposure. The photo stability testing revealed that all polyphenols were stable for 48 h when SDP80 was conditioned in amber or transparent flasks and exposed to UV-C radiation (light express LE UV, 254 nm, 30W). In contrast, when unprotected, the polyphenols demonstrated to be sensitive to both, thermal stress testing (80 +/- 2 degrees C), for 14 days and to UV-C radiation. Luteolin showed to be the most stable against UVC light and 3-O-methylquercetin against temperature. The achyrobichalcone demonstrated to be the more unstable against both, temperature and light. The kinetics of polyphenol thermal degradation (80 +/- 2 degrees C, 49 days) and photodegradation (UV-C radiation, 96 h) followed, 2nd and 1st order reaction, respectively.
Recurrent Acute Hepatitis Associated with Use of Cetirizine (2004)

Although cetirizine is considered to have low potential for severe hepatic toxicity, the possibility that it can provoke autoimmune-mediated hepatotoxicity should be considered.
Scientific Opinion on the maintenance of the list of QPS biological agents intentionally added to food and feed (2013 update) (2013)

EFSA is requested to assess the safety of a broad range of biological agents in the context of notifications for market authorisation as sources of food and feed additives, enzymes and plant protection products. The qualified presumption of safety (QPS) assessment was developed to provide a harmonised generic pre-assessment to support safety risk assessments performed by EFSA's scientific Panels. The safety of unambiguously defined biological agents (at the highest taxonomic unit appropriate for the purpose for which an application is intended), and the completeness of the body of knowledge are assessed. Identified safety concerns for a taxonomic unit are, where possible and reasonable in number, reflected as 'qualifications' in connection with a recommendation for a QPS status. The list of QPS recommended biological agents is reviewed and updated periodically. Therefore, the only valid list is the one in the most recently published scientific opinion. The 2013 update reviews previously assessed microorganisms including bacteria, yeasts, filamentous fungi, oomycetes and viruses used for plant protection purposes. All taxonomic units previously recommended for the QPS list had their status reconfirmed. The new notifications since the last QPS update were reviewed. Gluconobacter oxydans and Alphaflexiviridae were assessed for the first time and were recommended for the QPS list. The information of the previous opinion was updated for the taxonomic units on the QPS list. Qualifications for the taxonomic units included in the QPS recommended list were reviewed and confirmed. Filamentous fungi and enterococci were not recommended for the QPS list following updating and reviewing of current scientific knowledge.
Performance analysis of non-imaging Fresnel lens as a primary stage for CPV units (2018)

Fresnel lens is widely used in concentrating photovoltaic (CPV) systems as a primary optical element. It focuses sunlight on small solar cells or on the entrance apertures of secondary optical elements. In this work, we present a performance analysis of a non-imaging Fresnel lens as a primary optical element for different values of focal length. Results show, among others, the necessary use a secondary stage of concentration in order to achieve good performances in terms of the uniformity of the flux and a large acceptance angle compared with those of a Fresnel lens used alone.
The role of intravenous immunoglobulin in the treatment and prevention of neonatal bacterial infection. (1991)

N ewborn infants are uniquely susceptible to overwhelming bacterial infection. The incidence of such infections ranges from 1 to 10 per 1,000 live births, with preterm infants having significantly higher rates than term newborns.‘-5 The mortality rate from early-onset bacterial infection in the neonate currently ranges between 15% and 30% and morbidity in survivors is high. When meningitis occurs, serious sequelae occur in 30% to 50% of survivors.” Thus, despite the extensive supportive care provided in neonatal intensive care units and the use of potent new antimicrobial agents, we continue to lose far too many neonates to bacterial infection. This has led a number of investigators to explore the value of various forms of immunotherapy in the treatment and prophylaxis of neonatal infection.
A Cross-Layer Design for End-to-End On-Demand Bandwidth Allocation in Infrastructure Wireless Mesh Network (2007)

Wireless mesh networks have gained significant academic and industry attentions in the recent years. Supporting quality of service in wireless mesh networks is an important and challenging task which involves both medium access control and network layer design. In this paper, we investigate the problem of end-to-end on-demand bandwidth allocation in infrastructure wireless mesh networks. We formulate it as a combinatorial optimization problem, and prove that it is NP- hard. We present a polynomial time 2-approximation algorithm, MCRS (minimum consumption routing and scheduling), based on the concepts of consumption level for routing and bottom set for scheduling. Comprehensive simulation results show that MCRS achieves better performance than traditional methods based on minimum hop routing.
Effects of cortical stimulation on skilled motor functions in chronic stroke patients (2004)

Background and Hypothesis: There is no universally accepted strategy to promote recovery of function after chronic stroke, a leading cause of long-term motor disability among adults. In healthy volunteers is has been demonstrated that cortical stimulation enhances motor functions (Buetefisch et al. J. Neurophys. 2004, Nitsche et al. Cogn. Neuroscience 2003). Furthermore, evidence from animal data supports the view that cortical stimulation of the affected hemisphere might improve motor functions (Teskey et al. Neurol Res. 2003). It is therefore conceivable that cortical stimulation to the motor cortex of the affected hemisphere of patients suffering from chronic stroke might improve functional motor skills in the paretic hand. This hypothesis has been evaluated in a double-blind crossover study design.
Power6 Decimal Divide (2007)

The IEEE 754-R floating-point standard has defined the arithmetic and encodings of the new decimal floating-point format. The C and C++ standards as well as other language standards have proposed a new data type to help programmers exploit the performance of this new hardware format. The IBM Power6 microprocessor will soon release the first hardware implementation of this decimal floating-point format. A discussion of how the decimal division operation is implemented in high frequency BCD hardware and a comparison to other division methods is provided. This implementation reuses some popular binary division algorithms such as prescaling and non-restoring division to reduce the amount of additional hardware. Novel twists are applied to these algorithms to adapt them for BCD formatted numbers.
A new nonlinear zone-based beamforming method for point-of-care ultrasound: Algorithms and implementation (2014)

It is important to reduce the hardware complexity of a dynamic receive beamformer for point-of-care ultrasound imaging systems. In this paper, a new nonlinear zone-based beamforming (ZBF-NLI) method, which can regulate delay errors throughout the imaging depth while reducing the hardware complexity, is proposed. For quantitative evaluation, normalized pixel intensity error (NPE) and mean square error (MSE) were measured from the Field-II simulation and phantom experiments with the allowance error of 0.25 for 16-f0 delay focusing resolution in ZBF-NLI method. Also, the identical number of zones was utilized for both ZBF-LI and ZBF-NLI methods. As a results, the dynamic delays calculated by the ZBF-NLI method shows 0 of MSE, while the ZBF-LI method indicated 0.52. Also, from the 8-bit US images of Field-II simulation and phantom experiment, the 6.16 and 8.39 of normalized pixel intensity error of the ZBF-LI method could be eliminated, respectively, while utilizing the identical number of zones. The ZBF-NLI method was implemented on the low-cost FPGA chip (Spartan 6, Xilinx Inc., CA, USA) of the custom-built portable US imaging system, which indicated that the proposed ZBF-NLI method only requires 9.14% of memory compared to that of the ZBF-LI method (i.e., 16.84 KB vs. 184.32 KB).
Oxidation Resistance of AM60, AM50, AE42 and AZ91 Magnesium Alloys (2011)

Because of the rapid development in automotive, aircraft, and electro industry the use of light alloys and their development is extensively increased. This increase is especially evident in the use of light magnesium alloys. The advantage of the Mg-alloys is in the mass/strength ratio, i.e. small mass of final products and their good mechanical properties; these alloys also have a good corrosion resistance Magnesium alloys are usually used at room temperatures but they can also stay at higher temperatures and oxidizing atmospheres in different stages of processing, such as: overheating of the charge, melting, casting, heat treatment and mechanical processing, recycling etc. But those conditions result undesirable effects that change chemical properties and deteriorate structural properties of the surface layers. Therefore the knowledge of oxidation of Mg-alloys at different temperatures is important for development of new Mgbased materials and the optimization of their technological processes. Various Mg alloys: AE42, AZ91, AM50, and AM60 were exposed to oxidation at different temperatures in order to determinate high-temperature oxidation resistance.
Functional conformations of the nuclear 1α,25-dihydroxyvitamin D3 receptor (1997)

The nuclear hormone 1alpha,25-dihydroxyvitamin D3 (VD) has important cell regulatory functions. Various synthetic VD analogues are under investigation to identify candidates with an improved therapeutic profile against hyperproliferative diseases. VD directly activates the transcription factor VD receptor (VDR), which in turn stimulates the expression of a cascade of primary and secondary VD-responsive genes. The activation of the VDR through binding of its natural and synthetic ligands is linked to a conformational change presenting the interface with co-activator proteins, referred to as the (trans)activation function 2 (AF-2) domain. Multiple conformations of the VDR might be the key to understanding a selective action of VD analogues. The method of limited protease digestion was used here to characterize up to three different functional VDR conformations stabilized individually by VD and its analogues. The relative potency of VDR ligands can be quantified in the interaction with these VDR conformations by determination of a functional dissociation constant, where a two-concentration-point comparison has already provided important information. In this way seven amino acid residues in the AF-2 domain have been analysed as potential ligand contact points. Interestingly, residues Phe-422 and Val-418 seem to interact with all tested VDR ligands, whereas VD analogues such as the anti-psoriatic drug MC903 displayed additional contact points within the AF-2 domain. Taken together, limited protease digestion is a powerful method for studying functional VDR conformations and seems to be very appropriate for screening VD analogues.
Complete Genome Assembly of Staphylococcus epidermidis AmMS 205 (2014)

Staphylococcus epidermidis causes a large number of catheter-related sepsis infections annually in the United States. We present the 2.54-Mbp complete genome assembly of reference strain S. epidermidis AmMS 205, including a single 37.7-kbp plasmid. The annotated assembly is available in GenBank under accession numbers CP009046 and CP009047.