gebhart/patrepeval huggingface dataset:
Spray-Dried Powders as Nasal Absorption Enhancers of Cyanocobalamin. (2001)

The aim of this work is to describe and characterize a new spray-drying procedure for the production of nasal powders as an alternative to the conventional freeze-drying method. Cyanocobalamin was chosen as the active ingredient and loaded into five different nonsoluble vehicles with high water absorption ability. Then these hydrated particles were suspended in methylene chloride and spray-dried. Particle size, morphology, true, bulk and tapped density, percentage of compressibility, moisture content, water intake, and drug diffusion were studied and significant differences were obtained depending on the nature of the vehicle. The drying method, either the new spray- or the conventional freeze-drying, was less important. Interestingly, an inverse correlation was found between water uptake and drug diffusion. Microcrystalline cellulose, dextran microspheres, and crospovidone were chosen for an in vivo bioavailability study in rabbits. Three other nasal reference formulations and an intravenous solution were also administered. The spray-dried powders showed higher bioavailability than the three nasal reference formulations. The highest absorption enhancement was observed with cellulose microcrystalline powders, which provided a 25% mean absolute bioavailability, followed by crospovidone and dextran microspheres formulations with mean bioavailability values of 14% and 7%, respectively. In conclusion, the new spray-drying method is useful for the production of cyanocobalamin nasal powders.
Measurements and Observations of IP Multicast Traffic (1999)

In this report, we present measurements of IP multicast traffic taken at the University of California at Berkeley. We note that the volume and distribution of IP multicast traffic is highly variable, and can depend on a small number of active conversations. From examining many-way multimedia conferences, we note the need for some kind of conference control, either provided by the application or the users. We see that IP multicast conferencing traffic can exhibit characteristics very different from that of conventional wide-area data traffic. Finally, we show that scope control (controlling the extent of the propagation of data through the network) must be addressed by the network, because users have been seen to mismanage the scopes of their own transmissions. KEYWORDS: Internet, IP, multicast, MBONE, multimedia, traffic measurements. 1 Introduction Recent and current trends in networks are enabling various kinds of multimedia conferencing and distribution applications, which will mos...
Mastering OpenCV with Practical Computer Vision Projects (2012)

Each chapter in the book is an individual project and each project is constructed with step-by-step instructions, clearly explained code, and includes the necessary screenshots. You should have basic OpenCV and C/C++ programming experience before reading this book, as it is aimed at Computer Science graduates, researchers, and computer vision experts widening their expertise.
New parenteral anticoagulants in development (2010)

The therapeutic armamentarium of parenteral anticoagulants available to clinicians is mainly composed by unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), fondaparinux, recombinant hirudins (i.e. bivalirudin, desirudin, lepirudin) and argatroban. These drugs are effective and safe for prevention and/or treatment of thromboembolic diseases but they have some drawbacks. Among other inconveniences, UFH requires regular anticoagulant monitoring as a result of variability in the anticoagulant response and there is a risk of serious heparin-induced thrombocytopaenia (HIT). LMWH, fondaparinux and recombinant hirudins are mainly cleared through the kidneys and their use in patients with severe renal insufficiency may be problematic. LMWH is only partially neutralized by protamine while fondaparinux and recombinant hirudins have no specific antidote. Novel anticoagulants in development for parenteral administration include new indirect activated factor Xa (FXa) inhibitors (idrabiotaparinux, ultra-low-molecular-weight heparins [semuloparin, RO-14], new LMWH [M118]), direct FXa inhibitors (otamixaban), direct FIIa inhibitors (flovagatran sodium, pegmusirudin, NU172, HD1-22), direct FXIa inhibitors (BMS-262084, antisense oligonucleotides targeting FXIa, clavatadine), direct FIXa inhibitors (RB-006), FVIIIa inhibitors (TB-402), FVIIa/tissue factor inhibitors (tifacogin, NAPc2, PCI-27483, BMS-593214), FVa inhibitors (drotrecogin alpha activated, ART-123) and dual thrombin/FXa inhibitors (EP217609, tanogitran). These new compounds have the potential to complement established parenteral anticoagulants. In the present review, we discuss the pharmacology of new parenteral anticoagulants, the results of clinical studies, the newly planned or ongoing clinical trials with these compounds, and their potential advantages and drawbacks over existing therapies.
Invariance properties of Gabor filter-based features-overview and applications (2006)

For almost three decades the use of features based on Gabor filters has been promoted for their useful properties in image processing. The most important properties are related to invariance to illumination, rotation, scale, and translation. These properties are based on the fact that they are all parameters of Gabor filters themselves. This is especially useful in feature extraction, where Gabor filters have succeeded in many applications, from texture analysis to iris and face recognition. This study provides an overview of Gabor filters in image processing, a short literature survey of the most significant results, and establishes invariance properties and restrictions to the use of Gabor filters in feature extraction. Results are demonstrated by application examples.
<title>Gamut mapping using variable anchor points</title> (1998)

Recently, a variety of imaging devices are being used to represent electronic color images the reproduced color, however, is different from the original color because of the difference of producible colors on the devices. The range of producible colors offered by a device is referred to as its gamut. In his paper, a gamut-mapping algorithm (GMA) is proposed that can maintain device-independent color. Categorized as a parametric GMA, this algorithm utilizes variable anchor points to both reduce a sudden color change on the gamut boundary of the printer and to maintain a uniform color change during the mapping process. Accordingly, the proposed algorithm can reproduce high quality images with low-cost color devices.
Effects of Alkali Treatment to Reinforcement on Tensile Properties of Curaua Fiber Green Composites (2004)

Alkali treatment was performed on ‘Curaua' fibers to improve their mechanical properties. Curaua fibers were dipped into 5%, 10%, and 15% concentrated sodium hydroxide solutions for 1h and 2h. The effects of solution concentrations and treatment times on the physical and mechanical properties of curaua fibers were evaluated. Tensile tests of untreated and alkali treated curaua fibers were carried out. Those results showed that the tensile strength of the treated fibers decreased in comparison to untreated fibers, whereas the fracture strain of the treated fibers increased greatly in comparison with that of untreated fibers. In addition, green composites reinforced by untreated and alkali-treated curaua fibers were fabricated by a press forming method. Tensile tests were carried out for both composites. Results showed that both tensile strength and fracture strain of the composite using treated fibers increased in comparison with the composite using untreated fibers.
An Intelligent Smart Home Control Using Body Gestures (2006)

This paper proposes the control of smart home environments such as lights and curtains using body gestures. We use a forward spotting scheme that executes gesture segmentation and recognition simultaneously. The start and end points of gestures are determined by zero crossing from negative to positive (or from positive to negative) of a competitive differential observation probability that is defined by the difference of observation probability between the maximal gesture and the non-gesture. We also use the sliding window and accumulative HMMs. We apply the proposed simultaneous gesture segmentation and recognition method to recognize the upperbody gestures for controlling the curtains and lights in a smart home environment. Experimental results show that the proposed method has a good recognition rate of 95.42% for continuously changing gestures.
A stand-alone and SMS-based approach for authentication using mobile phone (2013)

A secure network partially depends on user authentication and unfortunately authentication schemes used at present are not utterly secure. Most of the systems today rely on static passwords to verify the user's identity. This paper describes a method of implementing two factor authentication using mobile phones. The proposed system involves using a mobile phone as a software token for One Time Password generation. OTP algorithm powered with user's unique identifications like International Mobile Equipment Identification and Subscriber Identification Module; makes a finite alphanumeric token valid for a session and for a single use. The generated One Time Password is valid for only a short user defined period of time and is generated by factors that are unique to both, the user and the mobile device itself. Additionally, an SMS-based mechanism is implemented as both a backup mechanism for retrieving the password and as a possible mean of synchronization.
Using Color, Texture and Object-Based Image Analysis of Multi-Temporal Camera Data to Monitor Soil Aggregate Breakdown (2017)

Remote sensing has shown its potential to assess soil properties and is a fast and non-destructive method for monitoring soil surface changes. In this paper, we monitor soil aggregate breakdown under natural conditions. From November 2014 to February 2015, images and weather data were collected on a daily basis from five soils susceptible to detachment (Silty Loam with various organic matter content, Loam and Sandy Loam). Three techniques that vary in image processing complexity and user interaction were tested for the ability of monitoring aggregate breakdown. Considering that the soil surface roughness causes shadow cast, the blue/red band ratio is utilized to observe the soil aggregate changes. Dealing with images with high spatial resolution, image texture entropy, which reflects the process of soil aggregate breakdown, is used. In addition, the Huang thresholding technique, which allows estimation of the image area occupied by soil aggregate, is performed. Our results show that all three techniques indicate soil aggregate breakdown over time. The shadow ratio shows a gradual change over time with no details related to weather conditions. Both the entropy and the Huang thresholding technique show variations of soil aggregate breakdown responding to weather conditions. Using data obtained with a regular camera, we found that freezing-thawing cycles are the cause of soil aggregate breakdown.
Gravitational effects on body composition in birds. (1975)

Gallinaceous birds, presenting a wide range of body size, were adapted physiologically to hyperdynamic environments, provided by chronic centrifugation. Chemical composition was measured directly on prepared carcasses, which were anatomically comparable, and more amenable to analysis than the intact body. Body mass and body fat decreased arithmetically with increasing field strength and also with increasing body mass. Water content of lean tissue increased in hyperdynamic environments, but irrespectively of body size.
Antimicrobial effect of the lactoperoxidase system in milk activated by immobilized enzymes (1995)

Abstract Immobilized lactase and glucose oxidase were used to produce H2O2 to activate the lactoperoxidase system in milk. The enzymes were immobilized on nylon pellets. With a ratio of 35 g of catalyst/L of milk, a concentration of 0.75 mM was produced in 3 min. Raw milk treatment with the catalyst reduced coliforms by 79%; Staphylococcus aureus reduction was 68%, psychrotrophs 91%, and fungi 100%. Results were similar when milk was treated by addition of H2O2. Thiocyanate was not limiting because addition of NaSCN did not increase the effectiveness of the lactoperoxidase system. The stability of the catalyst was poor when successive treatments were applied to milk, having lost one half of the activity every eight determinations. Activation of the lactoperoxidase system by immobilized enzymes could be of interest if stability could be ensured.
Elastic reflectivity vectors and the geometry of intercept-gradient crossplots (2019)

Abstract Reflectivities of elastic properties can be expressed as a sum of the reflectivities of P-wave velocity, S-wave velocity, and density, as can the amplitude-variation-with-offset (AVO) parameters, intercept, gradient, and curvature. This common format allows elastic property reflectivities to be expressed as a sum of AVO parameters. Most AVO studies are conducted using a two-term approximation, so it is helpful to reduce the three-term expressions for elastic reflectivities to two by assuming a relationship between P-wave velocity and density. Reduced to two AVO components, elastic property reflectivities can be represented as vectors on intercept-gradient crossplots. Normalizing the lengths of the vectors allows them to serve as basis vectors such that the position of any point in intercept-gradient space can be inferred directly from changes in elastic properties. This provides a direct link between properties commonly used in rock physics and attributes that can be measured from seismic data. The theory is best exploited by constructing new seismic data sets from combinations of intercept and gradient data at various projection angles. Elastic property reflectivity theory can be transferred to the impedance domain to aid in the analysis of well data to help inform the choice of projection angles. Because of the effects of gradient measurement errors, seismic projection angles are unlikely to be the same as theoretical angles or angles derived from well-log analysis, so seismic data will need to be scanned through a range of angles to find the optimum.
Comparative study of regulatory T cells expanded <i>ex vivo</i> from cord blood and adult peripheral blood (2012)

In this study, we expanded regulatory T cells (Tregs) ex vivo from CD4(+) CD25(+) T cells from cord blood (CB) and CD4(+) CD25(+) CD127(-) T cells from adult peripheral blood (APB) and compared the suppressive functions of the newly generated Tregs. The Tregs from CB and APB were expanded either in two cycles with a polyclonal stimulus or in two cycles with an alloantigen stimulus in the first cycle and a polyclonal stimulus in the second cycle. Cell yield after Treg expansion with polyclonal stimulation was greater than that of Tregs expanded with combined alloantigen and polyclonal stimulation. The expanded Tregs expressed high levels of Foxp3, CD39 and cytotoxic T-lymphocyte antigen-4 and low levels of CD127, interleukin-2 and interferon-γ. After two cycles of expansion, the CB Tregs maintained expression of the GARP gene and showed greater suppressive function than APB Tregs. The CB Tregs that were expanded with two cycles of polyclonal stimulation suppressed not only the polyclonal antigen-driven responder T (T(resp)) cell proliferation but also the HLA mismatched dendritic cell-driven T(resp) cell proliferation. When CB and APB Tregs were expanded with a primary alloantigen stimulus followed by a secondary polyclonal stimulus, the Tregs showed a potent, antigen-specific suppressive capacity. The Tregs expanded with two cycles of polyclonal stimulation from both CB and APB alleviated acute graft-versus-host disease symptoms and prolonged survival in a murine model of graft-versus-host disease. In conclusion, CB Tregs expanded with two cycles of polyclonal stimulation had a stronger immunosuppressive function than APB Tregs. It is feasible to obtain human functional alloantigen-specific Tregs expanded ex vivo from CB and APB in large numbers.
Talc Deposition in Skin and Tissues Surrounding Silicone Gel-Containing Prosthetic Devices (1994)

The high incidence of talc deposition in the skin and tissues surrounding silicone implants suggests that talc either is introduced at the time of implant surgery (possibly in association with the silicone elastomer bag, tissue sizers, or surgical gloves) or is released into the tissues as a silicone gel contaminant during gel bleed. Talc, a known sclerosing agent, may contribute to periprosthetic fibrosclerosis.
Analyzing Effects of Naturally Occurring Missense Mutations (2012)

Single-point mutation in genome, for example, single-nucleotide polymorphism (SNP) or rare genetic mutation, is the change of a single nucleotide for another in the genome sequence. Some of them will produce an amino acid substitution in the corresponding protein sequence (missense mutations); others will not. This paper focuses on genetic mutations resulting in a change in the amino acid sequence of the corresponding protein and how to assess their effects on protein wild-type characteristics. The existing methods and approaches for predicting the effects of mutation on protein stability, structure, and dynamics are outlined and discussed with respect to their underlying principles. Available resources, either as stand-alone applications or webservers, are pointed out as well. It is emphasized that understanding the molecular mechanisms behind these effects due to these missense mutations is of critical importance for detecting disease-causing mutations. The paper provides several examples of the application of 3D structure-based methods to model the effects of protein stability and protein-protein interactions caused by missense mutations as well.
Eleven Years of Experience with the Inflatable Penile Prosthesis (1988)

The 11-year experience with 395 consecutive patients in whom an inflatable prosthesis was implanted for the treatment of chronic erectile impotence is reported. Among these patients the most common etiology was vascular disease, followed by diabetes mellitus and radical pelvic surgery. The original American Medical Systems prosthesis with PPT cylinders shows a 61 per cent complication and revision rate with followup from 3 to 11 years. The newer inflatable prostheses manufactured since 1983 have needed revision in only 13 per cent of the patients followed to 4 years. Salvage procedures and increased product reliability have resulted in 97 per cent of the patients being satisfied. Five types of inflatable prostheses are compared and advantages are discussed.
Variability of tobacco mosaic virus in relation to control of tomato mosaic in glasshouse tomato crops by resistance breeding and cross protection (1975)

Various strains of TMV occur in susceptible crops of tomato.This variability is of importance to resistance breeding and to cross protection as alternative methods of control.Strains of TMV differ in the kind of symptoms expressed and in the extent of the host range.Symptom variation allows for the distinction of eight strains of which the tomato strain is the most important.On a host range including Solanum pennellii, Lycoperskon esculentum CStMW-18 and L. pemvianum four strains are differentiated which correspond with Pelham's Strains 0,1,2 and 2.Strains of TMV also differ as to longevity in vitro.The prevailing Strain 0 and Strain 1 are more persistent than Strain 2. The instability shown by Strain 2 during isolation suggests that in practice it may not easily overcome the resistance of the gene Tm-2*.The symptomless nitrous acid mutant Mll-16 which is discussed in relation to cross protection is also less persistent than its parent tomato strain.This necessitated a careful preparation of the inocula for commercial use.
Distribution of Ovary Ecdysteroidogenic Hormone I in the nervous system and gut of mosquitoes (2001)

Ovary ecdysteroidogenic hormone I (OEH I) is a gonadotropin in the female mosquito, Aedes aegypti. Whole-mount immunocytochemistry using OEH I antisera revealed an extensive distribution of immunostained cells in larvae and adults of this mosquito comparable to that observed in the African malaria mosquito, Anopheles gambiae. Medial neurosecretory cells were stained in brains of larvae and adult Ae. aegypti. In An gambiae the lateral neurosecretory cells were stained more often. In both species, immunostained axons from these cells extended out of the brain through the neurohemal organ associated with the aorta and branched extensively along the midgut. Immunostained endocrine cells were observed in larval and adult midguts of both species. In adults, abdominal metameric perivisceral organs were stained. Stained axons interconnected the perivisceral organs and neurosecretory cells in the abdominal ganglia. Episodic release of OEH I from these organs was evident in female Ae. aegypti, when staining disappeared at 12 hours after a blood meal and returned by 48 hours to levels observed before and up to 2 hours after the blood meal. Two sites were specifically stained only in An. gambiae: an axon net around the pyloric valve in the hindgut of larvae and adults and a ring of endocrine cells in the cardiac valve in the larval midgut. The markedly similar localizations of immunostained cells in larvae and adults of two distantly related species indicate that OEH I, or a homolog, is conserved within this group of Diptera and likely has stage- and sex-specific functions.
Epithelial paracellular proteins in health and disease (2006)

Tight-junction-targeted research may help not only in the future design of novel therapies against invading microorganisms, but also may promote passage of medications through the normally sealed epithelial barrier. In addition, the regulatory properties of tight junctions may help in the understanding of still unanswered aspects of epithelial ion transport.
A two‐stage approach for measuring vascular water exchange and arterial transit time by diffusion‐weighted perfusion MRI (2011)

Changes in the exchange rate of water across the blood-brain barrier, denoted k(w), may indicate blood-brain barrier dysfunction before the leakage of large-molecule contrast agents is observable. A previously proposed approach for measuring k(w) is to use diffusion-weighted arterial spin labeling to measure the vascular and tissue fractions of labeled water, because the vascular-to-tissue ratio is related to k(w). However, the accuracy of diffusion-weighted arterial spin labeling is affected by arterial blood contributions and the arterial transit time (τ(a)). To address these issues, a two-stage method is proposed that uses combinations of diffusion-weighted gradient strengths and post-labeling delays to measure both τ(a) and k(w). The feasibility of this method was assessed by acquiring diffusion-weighted arterial spin labeling data from seven healthy volunteers. Repeat measurements and Monte Carlo simulations were conducted to determine the precision and accuracy of the k(w) estimates. Average grey and white matter k(w) values were 110 ± 18 and 126 ± 18 min(-1), respectively, which compare favorably to blood-brain barrier permeability measurements obtained with positron emission tomography. The intrasubject coefficient of variation was 26% ± 23% in grey matter and 21% ± 17% in white matter, indicating that reproducible k(w) measurements can be obtained.