gebhart/patrepeval huggingface dataset:
Conformation–activity relationship of a novel peptide antibiotic: Structural characterization of dermaseptin DS 01 in media that mimic the membrane environment (2005)

Dermaseptins, small polycationic peptides synthesized by amphibians, exert a lytic action on bacteria, protozoa, yeast, and filamentous fungi at micromolar concentrations, but unlike polylysines, show little hemolytic activity. Dermaseptins S are active only against bacteria and form aggregates at high peptide/lipid ratios, whereas dermaseptins B are active also against fungi and form aggregates at low peptide/lipid ratios. A new dermaseptin, named DS 01, from the skin secretion of Phyllomedusa oreades, showed not only strong antibacterial properties against Gram-positive and Gram-negative bacteria but also antiprotozoan activity in the microM range. An analysis of the sequences of all dermaseptins only shows a common tendency to adopt amphipathic helical conformations but does not hint at significant differences. In order to rationalize the biological differences among dermaseptins, it is necessary to analyze their conformational properties in greater detail. A structural characterization in media that mimic the membrane environment shows that the surface properties of DS 01, as compared to those of dermaseptins S1 and B2, are intermediate, in agreement with its peculiar pharmacological profile. The regular alternation of positive and negative patches on the surface suggests a plausible aggregation mechanism.
Development of Solid Oxide Fuel Cell Operated at Intermediate Temperature for Direct Utilization of Dimethylether Fuel - Investigation of Anode Catalysts (2007)

We have developed the intermediate-temperature solid oxide fuel cell (SOFC) with a proton conducting oxide BaCe0.8Y0.2O3-d(BCY20) as the electrolyte for direct utilization of dimethyl ether (DME) fuel. In present study, we tried to improve the cell performance of the SOFC with using Fe as a catalyst for the anode. The maximum power density of the SOFC (DME+H2O, Fe|BCY20|Pt, dry air) was 44mW•cm-2 at 600{degree sign}C. The SOFC was able to perform at even 500{degree sign}C. Consequently, direct DME SOFC performance is substantially enhanced at temperatures 500{degree sign}C - 600{degree sign}C by use of Fe as anode catalyst.
Nonlinear analytical model of two weakly coupled MEMS cantilevers for mass sensing using electrostatic actuation (2018)

International audience
Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway (2015)

Chondrosarcoma is a malignant tumor that produces cartilage matrix. The most lethal aspect is its metastatic property. We demonstrated that amphiregulin (AR) is significantly upregulated in highly aggressive cells. AR silencing markedly suppressed cell migration. Exogenous AR markedly increased cell migration by transactivation of α6β1 integrin expression. A neutralizing α6β1 integrin antibody can abolish AR-induced cell motility. Knockdown of AR inhibits metastasis of cells to the lung in vivo. Furthermore, elevated AR expression is positively correlated with α6β1 integrin levels and higher grades in patients. These findings can potentially serve as biomarker and therapeutic approach for controlling chondrosarcoma metastasis.
The challenge to NO <sub>x</sub> emission control for heavy-duty diesel vehicles in China (2012)

Abstract. China's new "Twelfth Five-Year Plan" set a target for total NOx emission reduction of 10% for the period of 2011–2015. Heavy-duty diesel vehicles (HDDVs) have been considered a major contributor to NOx emissions in China. Beijing initiated a comprehensive vehicle test program in 2008. This program included a sub-task for measuring on-road emission profiles of hundreds of HDDVs using portable emission measurement systems (PEMS). The major finding is that neither the on-road distance-specific (g km −1) nor brake-specific (g kW h−1) NOx emission factors for diesel buses and heavy-duty diesel trucks improved in most cases as emission standards became more stringent. For example, the average NOx emission factors for Euro II, Euro III and Euro IV buses are 11.3±3.3 g km−1, 12.5± 1.3 g km−1, and 11.8±2.0 g km−1, respectively. No statistically significant difference in NOx emission factors was observed between Euro II and III buses. Even for Euro IV buses equipped with SCR systems, the NOx emission factors are similar to Euro III buses. The data regarding real-time engine performance of Euro IV buses suggest the engine certification cycles did not reflect their real-world operating conditions. These new on-road test results indicate that previous estimates of total NOx emissions for HDDV fleet may be significantly underestimated. The new estimate in total NOx emissions for the Beijing HDDV fleet in 2009 is 37.0 Gg, an increase of 45% compared to the previous study. Further, we estimate that the total NOx emissions for the national HDDV fleet in 2009 are approximately 4.0 Tg, higher by 1.0 Tg (equivalent to 18% of total NOx emissions for vehicle fleet in 2009) than that estimated in the official report. This would also result in 4% increase in estimation of national anthropogenic NOx emissions. More effective control measures (such as promotion of CNG buses and a new in-use compliance testing program) are urged to secure the goal of total NOxmitigation for the HDDV fleet in the future.
Local redundancy and progressive bounds on the redundancy of a Huffman code (1991)

The concept of local redundancy is introduced, and it is shown that it is a simple but powerful tool for understanding the redundancy of a prefix code. Based on this concept, the redundancy of a prefix code when the structure of the code is partially known is proven. It is shown how this theorem can be used to obtain well-known lower bounds on R/sub Huff/, the redundancy of a Huffman code. The theorem is used to obtain a sequence of new lower bounds on R/sub Huff/ based on the Huffman procedure. A similar sequence of upper bounds on R/sub Huff/ is obtained. New lower and upper bounds on R/sub Huff/ when the two smallest probabilities of the source distribution are known are given as corollaries of these results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Data acquisition and dose distribution for the neutron therapy beam at the TAMVEC facility by a computer controlled system (1974)

A computer controlled system developed for data acquisitions and production of isodose plots was used to obtain data at a cyclotron facility for fast neutron therapy. The measurements were taken to verify the accuracy of computer-generated isodose plots produced by the decrement line method. Plots were produced on line for the neutron beam produced by 16 MeV deuterons incident upon a thick beryllium target. Measurements were made in a 40*40*40 cm lucite tank filled with tissue-equivalent liquid with an air-filled cylindrical ionization chamber constructed of tissue equivalent plastic and having a volume of 0.1 cm3. The system was described and isodose distributions, depth dose data and beam profiles of selected open beams and beams obtained with polyethylene wedges were presented.
329 Assessment by tissue Doppler imaging of left ventricular diastolic dysfunction in a rat model of aging heart (2006)

s S41 Eur J Echocardiography Abstracts Supplement, December 2006 MYOCARDIAL VELOCITY IMAGING (DMI) – LV FUNCTION
Ce<sup>3+</sup>/Tb<sup>3+</sup> non‐/single‐/co‐doped K‐Lu‐F materials: synthesis, optical properties, and energy transfer (2015)

Using a hydrothermal method, Ce(3+) /Tb(3+) non-/single-/co-doped K-Lu-F materials have been synthesized. The X-ray diffraction (XRD) results suggest that the Ce(3+) and/or Tb(3+) doping had great effects on the crystalline phases of the final samples. The field emission scanning electron microscopy (FE-SEM) images indicated that the samples were in hexagonal disk or polyhedron morphologies in addition to some nanoparticles, which also indicated that the doping also had great effects on the sizes and the morphologies of the samples. The energy-dispersive spectroscopy (EDS) patterns illustrated the constituents of different samples. The enhanced emissions of Tb(3+) were observed in the Ce(3+) /Tb(3+) co-doped K-Lu-F materials. The energy transfer (ET) efficiency ηT were calculated based on the fluorescence yield. The ET mechanism from Ce(3+) to Tb(3+) was confirmed to be the dipole-quadrupole interaction inferred from the theoretical analysis and the experimental data. Copyright © 2015 John Wiley & Sons, Ltd.
Design and Application of a Cylindrical TM<sub>020</sub>Mode Applicator for the In-Line Microwave Preheating of Liquid Thermosets (1998)

This paper concerns the design and application of a cylindrical TMowmode applicator for in-line microwave preheating of precatalysed thermosetting resin during resin transfer moulding (RTM) .A 35% reduction in cycle time was achieved using such an applicator through the elimination of mould quench as cool resin was injected into a heated mould. Although this paper focuses on he precatalysed polyester resin, the results are applicable to the in-line heating of any viscous, temperature sensitive fluid where excessive heating of the laminar boundary layers is undesirable.
Luminescence Beam Profile Monitor for the RHIC Polarized Hydrogen Jet Polarimeter (2006)

A new polarized hydrogen jet target was used to provide improved beam polarization measurements during the second polarized proton run in the Relativistic Heavy Ion Collider (RHIC). The luminescence produced by beam-hydrogen excitations was also used to test the feasibility of a new beam profile monitor for RHIC based on the detection of the emitted light. Lenses, a view-port and a sensitive CCD camera were added to the system to record the optical signals from the interaction chamber. The first very promising results are reported here. The same system with an additional optical spectrometer or optical filter system may be used in the future to detect impurities in the jet, such as oxygen molecules, which affect the accuracy of the polarization measurements.
Stereoselective Formation ofa β-Lactam Fused Oxathiazepin: A Synthetic Approachto Eudistomins (2003)

A synthetic approach to eudistomin via a β-lactam fused bicyclic oxathiazepin intermediate is described. A β-lactam fused oxathiazepin derivative was synthesized by intramolecular 7-membered oxime ether formation and subsequent face-selective reduction of the C-N double bond. A fully functionalized ortho-alkenylphenylthioanilide bearing oxathiazepin ring was then prepared and construction of the indole skeleton under several radical-mediated conditions was examined.
Negative high-frequency differential conductivity in semiconductor superlattices (2003)

We examine the high-frequency differential conductivity response properties of semiconductor superlattices having various miniband dispersion laws. Our analysis shows that the anharmonicity of Bloch oscillations (beyond tight-binding approximation) leads to the occurrence of negative high-frequency differential conductivity at frequency multiples of the Bloch frequency. This effect can arise even in regions of positive static differential conductivity. The influence of strong electron scattering by optic phonons is analyzed. To achieve terahertz field amplification, we propose employing structures having minibands with effective electron mass that decreases as the electron energy increases.
Identification of high levels of protein phosphatase‐1 in rat liver nuclei (1986)

Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the beta-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.
Reactive uptake of acetic acid on calcite and nitric acid reacted calcite aerosol in an environmental reaction chamber (2007)

The heterogeneous chemistry of gas-phase acetic acid with CaCO(3)(calcite) aerosol was studied under varying conditions of relative humidity (RH) in an environmental reaction chamber. Infrared spectroscopy showed the loss of gas-phase reactant and the appearance of a gaseous product species, CO(2). The acetic acid is observed to adsorb onto the calcite aerosol through both a fast and a slow uptake channel. While the fast channel is relatively independent of RH, the slow channel exhibits enhanced uptake and reaction as the RH is increased. In additional experiments, the calcite aerosol was exposed to both nitric and acetic acids in the presence of water vapor. The rapid conversion of the particulate carbonate to nitrate and subsequent deliquescence significantly enhances the uptake and reaction of acetic acid. These results suggest a possible mechanism for observed correlations between particulate nitrate and organic acids in the atmosphere. Calcium rich mineral dust may be an important sink for simple organic acids.
Computer-Aided Song Design: Prosody as Scaffolding (2001)

hymns, poetry or the libretto of an opera. A plausible point of departure for writing melodies for a text is to study the prosody of the text as spoken either naturally or dramatically. In this paper we introduce PROSE: a system for aiding such study. The system extracts the prosody of a spoken signal and (re)synthesises it at various resolutions. The main advantages of using PROSE over simply listening to the spoken signals are that composers can focus on prosodic auditory information detached from the meaning of the text and can assess this information at various resolutions. Also, the analysis data can be plotted for visual assessment and/or mapped onto musical parameters.
Tularemia (2002)

Francisella tularensis is the etiological agent of tularemia, a serious and occasionally fatal disease of humans and animals. In humans, ulceroglandular tularemia is the most common form of the disease and is usually a consequence of a bite from an arthropod vector which has previously fed on an infected animal. The pneumonic form of the disease occurs rarely but is the likely form of the disease should this bacterium be used as a bioterrorism agent. The diagnosis of disease is not straightforward. F. tularensis is difficult to culture, and the handling of this bacterium poses a significant risk of infection to laboratory personnel. Enzyme-linked immunosorbent assay- and PCR-based methods have been used to detect bacteria in clinical samples, but these methods have not been adequately evaluated for the diagnosis of pneumonic tularemia. Little is known about the virulence mechanisms of F. tularensis, though there is a large body of evidence indicating that it is an intracellular pathogen, surviving mainly in macrophages. An unlicensed live attenuated vaccine is available, which does appear to offer protection against ulceroglandular and pneumonic tularemia. Although an improved vaccine against tularemia is highly desirable, attempts to devise such a vaccine have been limited by the inability to construct defined allelic replacement mutants and by the lack of information on the mechanisms of virulence of F. tularensis. In the absence of a licensed vaccine, aminoglycoside antibiotics play a key role in the prevention and treatment of tularemia.
Morbid Obesity and Obstructive Sleep Apnea: The Challenging Link (2011)

Obstructive sleep apnea (OSA) is a common medical condition that is increasing in prevalence and is associated with substantial morbidity and a 40% eight-year mortality rate if left untreated. Morbidly obese patients have a greater incidence of co-morbid disease, including OSA. OSA is characterized by repeated upper airway obstruction and arousal during sleep, sympathetic activation, hypertension and daytime somnolence. In morbidly obese OSA patients undergoing surgical procedures, the perioperative period is more challenging than in non obese OSA patients. Their airway anatomy is often abnormal with excess pharyngeal tissue and tongue size making it difficult to ventilate thru a facemask and to establish tracheal intubation. Several suggestions for optimizing the anesthetic induction, emergence, and early recovery periods in these patients are offered. Most important are positioning of the patient (both during and post surgery), pre-oxygenation prior to intubation, proper dosing of anesthetic maintenance drugs to ideal body weight, alveolar recruitment maneuvers, full reversal of paralysis at the end of surgery, and careful drug titration in recovery to improve pulmonary mechanics. With proper preparation and precautions it is possible to avoid the significant high frequency of respiratory and cardiac complications observed in these patients and to avoid or better manage length of hospital stay, unplanned ICU admission and/or reintubation.
An Architectural Level Energy Reduction Technique For Deep-Submicron Cache Memories (2002)

An architectural level technique for a high performance and low energy cache memory is proposed in this paper. The key idea of our approach is to divide a cache memory into several number of cache blocks and to activate a few parts of the cache blocks. The threshold voltage of each cache block is dynamically changed according to the utilization of each block. Frequently accessed cache blocks are woken up and others are put to sleep by controlling the threshold voltage. Since time overhead to change the threshold voltage can not be neglected, predicting a cache block which will be accessed in the next cycle is important. A history based prediction technique to predict cache blocks which should be woken up is also proposed. Experimental results demonstrated that the leakage energy dissipation in cache memories optimized by this approach can be less than 5% of energy dissipation in a cache memory which does not employ the approach.
Study on Aerostatic Lead Screw : Manufacture of 200mm stroke lead screw (2003)

This study is related on the performance improving of the aerostatic lead screw. It is characterized by the followings; free from friction and wear, no trouble due to air leakage, and so forth. Therefore, an aerostatic lead screw is adopted in the precision positioning device by reason of achieving higher positioning accuracy. We designed and manufactured the aerostatic lead screw of 200mm stroke as second trial production. As a result, we succeeded to measure; maximum cumulative pitch error of every 3 pitches is 13μm, angle of male screw thread is 60°3', static stiffness toward axial direction is 3.3N/μm experimentally when a clearance between male and female screws is 17μm.
ChemInform Abstract: Alkaloid Synthesis via Carbenoid Intermediates (2016)

Abstract Review: 138 refs.
Model-Averaged Interference Rejection Combining (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We present a novel algorithm for interference suppression when the number of interferers is unknown. The key idea is to parameterize the second-order statistics of the interference via a mixture of several low-rank models. Numerical examples illustrate the performance of the method. </para>
Pathloss and Multipath Power Decay of the Wideband Car-to-Car Channel at 5.7 GHz (2011)

In this paper we present parametrization for pathloss regarding the wideband car-to-car channel at 5.7 GHz. Furthermore, we investigate the power decay of delay-resolved multipath components, categorized in LOS and NLOS paths, and discuss the results. The results show relatively high pathloss exponents and a strong dependency of the exponent on the LOS path, which carries the main part of signal power. The parametric equations and the parametrization were derived on the basis of 2 × 2 Multiple Input Multiple Output (MIMO) channel measurements in and around the city of Berlin in Germany.
Tuning characteristics and new laser lines in an Nd:YAP CW laser (1986)

We have investigated the CW laser properties of Nd doped Yttrium‐Aluminum‐Perovskite (YAP) in a Kr arc‐lamp, pumped cavity. Seven laser transitions within the 4F3/2−4I11/2 multiplet have been observed with thresholds and power outputs comparable to the corresponding transitions in Nd:YAG. A simple Lyot filter in the cavity is used to select the transition. The addition of a thin, uncoated etalon enabled us to obtain the tuning characteristics of the transitions at 1079.5nm and 1084.5nm. Tuning widths of 3nm are obtained.
A Synthetic Peptide Homologous to Functional Domain of Human IL-10 Down-Regulates Expression of MHC Class I and Transporter Associated with Antigen Processing 1/2 in Human Melanoma Cells (2004)

Tumor cells treated with IL-10 were shown to have decreased, but peptide-inducible expression of MHC class I, decreased sensitivity to MHC class I-restricted CTL, and increased NK sensitivity. These findings could be explained, at least partially, by a down-regulation of TAP1/TAP2 expression. In this study, IT9302, a nanomeric peptide (AYMTMKIRN), homologous to the C-terminal of the human IL-10 sequence, was demonstrated to mimic these previously described IL-10 effects on MHC class I-related molecules and functions. We observed a dose-dependent down-regulation of MHC class I at the cell surface of melanoma cells after 24-h treatment with IT9302. The IL-10 homologue peptide also caused a dose-dependent inhibition of the IFN-gamma-mediated surface induction of MHC class I in a melanoma cell line. We demonstrated, using Western blot and flow cytometry, that IT9302 inhibits the expression of TAP1 and TAP2 proteins, but not MHC class I H chain or low molecular protein molecules. Finally, peptide-treated melanoma cells were shown to be more sensitive to lysis by NK cells in a dose-dependent way. Taken together, these results demonstrate that a small synthetic peptide derived from IL-10 can mimic the Ag presentation-related effects mediated by this cytokine in human melanomas and increase tumor sensitivity to NK cells, which can be relevant in the designing of future strategies for cancer immune therapy.
Differential Item Functioning on the SAT‐M Braille Edition (1989)

This study attempted to pinpoint the causes of differential item difficulty for blind students taking the braille edition of the Scholastic Aptitude Test's Mathematical section (SAT‐M). The study method involved reviewing the literature to identify factors that might cause differential item functioning for these examinees, forming item categories based on these factors, identifying categories that functioned differentially, and assessing the functioning o f the items comprising deviant categories to determine if the differential effect was pervasive. Results showed an association between selected item categories and differential functioning, particularly for items that included figures in the stimulus, items for which spatial estimation was helpful in eliminating at least two of the options, and items that presented figures that were small or medium in size. The precise meaning of this association was unclear, however, because some items from the suspected categories functioned normally, factors other than the hypothesized ones might have caused the observed aberrant item behavior, and the differential difficulty might reflect real population differences in relevant content knowledge