gebhart/patrepeval huggingface dataset:
Electronic Spectra of Thiazolo[5,4-<i>d</i>]Thiazole (1983)

Abstract The uv absorption spectrum of thiazolo[5,4-d]thiazole has been investigated for the vapour phase and by means of the linear dichroism of single crystals and liquid crystalline solutions. Two intense π* ← π electronic transitions are observed in the region of the near uv, while a Rydberg transition occurs around 50,000 cm−1 in the vapour spectrum. These results are substantiated by MCD spectroscopy and a comparison with data for the parent molecule thieno[3,2-b]thiophen is given.
Storage Consolidation on SSDs: Not Always a Panacea, but Can We Ease the Pain? (2015)

Storage Consolidation is increasing being adopted to reduce system costs, simplify the storage infrastructure, and enhance availability and resource management. However, consolidation leads to interference in shared resources. This poster shows the effect of consolidation on performance of co-located applications and proposes a static approach to reduce interference.
The p25 subunit of the dynactin complex is required for dynein–early endosome interaction (2011)

Cytoplasmic dynein transports various cellular cargoes including early endosomes, but how dynein is linked to early endosomes is unclear. We find that the Aspergillus nidulans orthologue of the p25 subunit of dynactin is critical for dynein-mediated early endosome movement but not for dynein-mediated nuclear distribution. In the absence of NUDF/LIS1, p25 deletion abolished the localization of dynein-dynactin to the hyphal tip where early endosomes abnormally accumulate but did not prevent dynein-dynactin localization to microtubule plus ends. Within the dynactin complex, p25 locates at the pointed end of the Arp1 filament with Arp11 and p62, and our data suggest that Arp11 but not p62 is important for p25-dynactin association. Loss of either Arp1 or p25 significantly weakened the physical interaction between dynein and early endosomes, although loss of p25 did not apparently affect the integrity of the Arp1 filament. These results indicate that p25, in conjunction with the rest of the dynactin complex, is important for dynein-early endosome interaction.
Placental Growth Factor-1 Potentiates Hematopoietic Progenitor Cell Mobilization Induced by Granulocyte Colony-Stimulating Factor in Mice and Nonhuman Primates (2006)

The complex hematopoietic effects of placental growth factor (PlGF) prompted us to test in mice and nonhuman primates the mobilization of peripheral blood progenitor cells (PBPCs) elicited by recombinant mouse PlGF-2 (rmPlGF-2) and recombinant human PlGF-1 (rhPlGF-1). PBPC mobilization was evaluated by assaying colony-forming cells (CFCs), high-proliferative potential-CFCs (HPP-CFCs), and long-term culture-initiating cells (LTC-ICs). In mice, both rmPlGF-2 and rhPlGF-1 used as single agents failed to mobilize PBPCs, whereas the combination of rhPlGF-1 and granulocyte colony-stimulating factor (rhG-CSF) increased CFCs and LTC-ICs per milliliter of blood by four- and eightfold, respectively, as compared with rhG-CSF alone. rhPlGF-1 plus rhG-CSF significantly increased matrix metalloproteinase-9 plasma levels over rhG-CSF alone, suggesting a mechanistic explanation for rhPlGF-1/rhG-CSF synergism. In rhesus monkeys, rhPlGF-1 alone had no mobilization effect, whereas rhPlGF-1 (260 microg/kg per day) plus rhG-CSF (100 microg/kg per day) increased rhG-CSF-elicited mobilization of CFCs, HPP-CFCs, and LTC-ICs per milliliter of blood by 5-, 7-, and 15-fold, respectively. No specific toxicity was associated with the administration of rhPlGF-1 alone or in combination. In conclusion, our data demonstrate that rhPlGF-1 significantly increases rhG-CSF-elicited hematopoietic mobilization and provide a preclinical rationale for evaluating rhPlGF-1 in the clinical setting.
ChemInform Abstract: A Preparatively Convenient Ligand‐Free Catalytic PEG 2000 Suzuki—Miyaura Coupling. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Adult phosphorylase <i>b</i> kinase deficiency (1990)

Phosphorylase b kinase deficiency affecting muscle has been observed infrequently in children with weakness and hepatomegaly, and in 2 adults with cramps on exertion. We observed 2 additional adults with phosphorylase b kinase deficiency: Patient 1, aged 58, had progressive, predominantly distal weakness since age 46 but no cramps on exertion; Patient 2, aged 26, had cramps on exertion since age 6 but no weakness. Lactate production on ischemic exercise was impaired only in Patient 1. The serum creatine kinase level was elevated in both. Muscle specimens showed focal glycogen excess in both, and a necrotizing myopathy and mild denervation atrophy in Patient 1. Muscle phosphorylase b kinase activity was 0.5% and 8.9% of the lowest control value in Patients 1 and 2, respectively; erythrocyte phosphorylase b kinase activity was normal in both; liver phosphorylase b kinase activity, measured in Patient 1, was also normal. Other glycolytic enzymes in muscle were preserved in both.
[An improved method for the determination of uric acid on a SMAC analyzer (author's transl)]. (1980)

Altering the analytical channel for the determination of uric acid on a SMAC analyzer affords greater analytical specificity and sensitivity. The proposed alterations do not require any change of the analyzer soft-ware.
Solid State AC Motor Drives - Conservation Perspectives (1982)

This paper presents and discusses techniques for energy conservation by reducing losses in ac motor driven systems, proposed by the technical community in response to surging cost of energy. An important aspect considered is the impact on electric utility systems in terms of harmonics and power factor of operation. The techniques evaluated in this paper are listed below. \n\n1. NASA Power Factor Controller: is a simple device for reducing power losses in lightly loaded ac motors. \n2. Conventional Variable Frequency Solid-State Inverters: can control the speed of ac motors by producing adjustable frequency ac voltage, with an enormous potential for energy conservation in pumps and air handling systems. \n3. Other Variable Frequency Drives: include cyclo converters, slip-recovery scheme, permanent magnet synchronous motors, etc.
Comparison of CPU level data mixing to T/R level data mixing architectures in optically controlled phased arrays (2002)

A performance comparison of a CPU level data mixing architecture and a T/R (transmit/receive) level data mixing at C-band is presented. The fiberoptic link used for transmission of the modulated carrier at 5.65+or-0.15 GHz has demonstrated insertion loss of approximately=11 dB, a compression dynamic range of 72 dB-MHz, and a spurious free dynamic range of 53 dB-MHz/sup 2/3/. The achieved results for the CPU level data mixing architecture using InGaAsP/InP-based components are higher than the results obtained for the AlGaAs/GaAs-based components for the T/R level data mixing architecture. This difference is a result of advances in the 1300 nm based components as opposed to the components available at the obsolete wavelength of 850 nm. In fact, when a T/R level data mixing architecture was constructed using the same type of devices used in the CPU level data mixing, a higher dynamic range was attained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Magnetosomes of magnetotactic bacteria (2006)

The ability of magnetotactic bacteria (MTB) to orient and migrate along magnetic field lines is basedon magnetosomes, which are membrane-enclosed intracellular crystals of a magnetic iron mineral. Thebiomineralization of magnetosomes is a process with genetic control over the accumulation of iron,the deposition of the magnetic crystal within a specific compartment, as well as their intracellularassembly and alignment into chain-like structures. Magnetite crystals produced by MTB have uniform species-specificmorphologies and sizes, which are mostly unknown from inorganic systems. In addition, magnetosome chainformation is an example of the highest structural level achievable in a prokaryotic cell. In thiswork, we give an overview of the biology of MTB and the structure and functions of bacterial magnetosomes.In addition we summarize the current knowledge of the physico-chemical and molecular genetic basis of magnetosomebiomineralization and chain formation.
Designing The Ubiquitous Microcellular Network (1995)

This paper summarises the cell design issues for microcellular networks and explains how conventional large cell network design techniques may not be suitable for designing a ubiquitous microcellular network. A general interference model developed for arbitrary microcellular networks, using a parameter denoted the `interference to noise ratio&apos; or INR, is used to determine the microcell spacing required to maintain certain cell coverage targets as a function of mutual spill power. It is shown that a contiguous cell coverage requirement imposes significant limits upon the accumulated interference allowable in a microcell system. 0 Introduction The popularity of mobile telecommunications has grown remarkably since the first commercial mobile cellular telecommunications service was launched in Chicago in October 1983. As the user base grew, the capacity of the cellular system had to be increased. The advantage of cellular radio systems is that capacity can be increased by splitting ex...
Pulsatile Perfusion Bioreactor for Biomimetic Vascular Impedances (2018)

Pulsatile waves of blood pressure and flow are continuously augmented by the resistance, compliance, and inertance properties of the vasculature, resulting in unique wave characteristics at distinct anatomical locations. Hemodynamically generated loads, transduced as physical signals into resident vascular cells, are crucial to the maintenance and preservation of a healthy vascular physiology; thus, failure to recreate biomimetic loading in vitro can lead to pathological gene expression and aberrant remodeling. As a generalized approach to improve native and engineered blood vessels, we have designed, built, and tested a pulsatile perfusion bioreactor based on biomimetic impedances and a novel five-element electrohydraulic analog. Here, the elements of an incubator-based culture system were formulaically designed to match the vascular impedance of a brachial artery by incorporating both the inherent (systemic) and added elements of the physical system into the theoretical approach. Freshly harvested porcine saphenous veins were perfused within a physiological culture chamber for 6 h and the relative expression of seven known mechanically sensitive remodeling genes analyzed using the quantitative polymerase chain reaction (qPCR) method. Of these, we found plasminogen activator inhibitor-1 (SERPINE1) and fibronectin-1 (FN1) to be highly sensitive to differences between arterial- and venous-like culture conditions. The analytical approach and biological confirmation provide a framework toward the general design of long-term hemodynamic-mimetic vascular culture systems.
Second Order PAC-Bayesian Bounds for the Weighted Majority Vote (2020)

We present a novel analysis of the expected risk of weighted majority vote in multiclass classification. The analysis takes correlation of predictions by ensemble members into account and provides a bound that is amenable to efficient minimization, which yields improved weighting for the majority vote. We also provide a specialized version of our bound for binary classification, which allows to exploit additional unlabeled data for tighter risk estimation. In experiments, we apply the bound to improve weighting of trees in random forests and show that, in contrast to the commonly used first order bound, minimization of the new bound typically does not lead to degradation of the test error of the ensemble.
Evidence for the Presence of the Platelet-Activating Factor Receptor in the CFW Mouse Preimplantation Two-Cell-Stage Embryo (1997)

Platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine; PAF), a potent signaling phospholipid, has a significant role in preimplantation embryo development. CFW mouse embryos respond to PAF with improved development and implantation rates. PAF's signal transduction mechanism in other cell types is receptor mediated. However, embryonic mRNA for the PAF receptor has not been detected. The study objectives were to determine the presence of PAF receptor mRNA in CFW mouse two-cell embryos by reverse transcription (RT)-polymerase chain reaction and Northern blot analysis and to ascertain the effect of PAF on intracellular calcium levels (a receptor-mediated event). Total RNA was purified by acid-phenol extraction and ethanol precipitation. Complementary DNA was synthesized by RT. RNA was primed with oligo-dT plus PAF receptor-specific primer (3' to 5') at 42 degrees C for 60 min, 95 degrees C for 10 min, and 5 degrees C for 5 min. The RT product was amplified with Taq polymerase and PAF receptor-specific primer (5' to 3') at 94 degrees C for 5 min and 54 degrees C for 5 min for one cycle, and at 72 degrees C for 3 min, 93 degrees C for 90 sec, and 61 degrees C for 150 sec for 30 cycles followed by 72 degrees C for 10 min and then holding at 4 degrees C. The product was analyzed by agarose gel electrophoresis, producing a single band (610 base pairs [bp]), thus demonstrating the presence of PAF-receptor mRNA. Sequence analysis of the cloned 610-bp fragment confirmed that it is the PAF receptor. Northern blot analysis also confirmed the expression of the PAF receptor in the CFW mouse preimplantation two-cell-stage embryo. PAF treatment of the two-cell-stage CFW mouse embryo resulted in a fourfold increase in intracellular calcium over background levels.
Señales producidas por Rhizobium leguminosarum en la interacción con frijol común (Phaseolus vulgaris L.) SIGNALS PRODUCED BY Rhizobium leguminosarum IN THE INTERACTION WITH COMMON BEAN (Phaseolus vulgaris L.) (2016)

Legume-Rhizobium interaction depends on a complex signal exchange that continues throughout the entire symbiotic process, out of which just the correct combination will give rise to an efficient symbiosis. These plants secrete flavonoids that are recognized by compatible bacteria inducing their nod genes, which encode proteins that synthesize and export lipochitooligosaccharides called Nod factors. These factors activate infection process and initiate cell division in the root until making up the nodule and also participate in nitrogen biological fixation. There is evidence that the use of nod gene inducers increases some legume nodulation. The objective of this work was to study the production of some signal molecules induced by genistein isoflavon in a R. leguminosarum strain as well as to evaluate induction impact on inoculum effect upon common bean plants. Inoculum lipid fraction was isolated with n-butanol and analyzed by thin layer chromatography, high performance liquid chromatography and gas chromatography coupled to a mass spectrometer. Regarding the inocula induced with genistein, a higher amount of lipooligosaccharides (Nod factors) and high-molecular- weight fatty acids were detected, showing significant differences with non-induced controls. Concerning such signal molecule enrichment, genistein-induced inocula had a positive effect on Cubacueto 25-9 bean plants, with a higher amount of nodules and chlorophyll content than non-inoculated plants (control).
Universal Kriging of RSS Databases in a Bayesian Filter (2018)

Received signal strength (RSS) based navigation is chosen for many indoor propagation scenarios because of the high availability and low cost of the needed infrastructure. Usually, RSS-based navigation relies on fingerprinting techniques. TRe-cently, methods for the spatial interpolation of RSS databases, including ordinary and universal Kriging have become the focus of research, as they can enhance these databases. This paper explores theoretical possibility of using universal Kriging as a measurement model in a Bayesian filter to give the possibility of using RSS databases in a deeply coupled information fusion filter, with the potential of enhancing the performance of other positioning systems. The method is applied on a simplified propagation model and an exemplary implementation in an extended Kalman filter is presented in detail and evaluated.
Expressed Enzymatic Ligation for the Semisynthesis of Chemically Modified Proteins (2003)

Enzymatic synthesis and expressed protein ligation were combined in a method for protein synthesis in which protein thioesters with specific leaving groups could be used by protease V8 from Staphylococcus aureus to catalyze the formation of peptide bonds. This method was applied to the synthesis of fluorescence-labeled (Fl) analogues of proneuropeptide Y (proNPY; see scheme). CBD=chitin binding domain.
Introduction (1997)

Imaging through the atmosphere is an important technology area, with applications in fields such as astronomy and remote sensing. For optimal results, many facets of signal collection and recovery must be understood. These facets include understanding relevant atmospheric effects, optimizing the signal collection system, and effectively processing the collected signals to obtain the desired imagery. Many different types of radiation can be used to obtain images through the atmosphere, including microwave, infrared, and optical. This radiation can be supplied by the object or natural sources (passive illumination), or it can be provided by the user (active illumination). This focus issue contains a number of invited papers describing imaging work being accomplished in the Advanced Optics and Imaging Division of the Air Force Research Laboratory, formerly the Optical Sensing Division of the Air Force Phillips Laboratory. These papers assume that optical or infrared radiation is being used, either actively or passively.
ChemInform Abstract: Three‐Component Cycloadditions: The First Transition Metal Catalyzed [5 + 2 + 1] Cycloaddition Reactions. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Digital image processing as an integral component of optical design (2008)

The design of modern imaging systems is intricately concerned with the control of optical aberrations in systems that can be manufactured at acceptable cost and with acceptable manufacturing tolerances. Traditionally this involves a multi-parameter optimisation of the lens optics to achieve acceptable image quality at the detector. There is increasing interest in a more generalised approach whereby digital image processing is incorporated into the design process and the performance metric to be optimised is quality of the image at the output of the image processor. This introduces the possibility of manipulating the optical transfer function of the optics such that the overall sensitivity of the imaging system to optical aberrations is reduced. Although these hybrid optical/digital techniques, sometimes referred as wavefront coding, have on occasion been presented as a panacea, it is more realistic to consider them as an additional parameter in the optimisation process. We will discuss the trade-offs involved in the application of wavefront coding to low-cost imaging systems for use in the thermal infrared and visible imaging systems, showing how very useful performance enhancements can be achieved in practical systems.
Structural characterization of the <i>Acetobacter xylinum</i> endo‐β‐1,4‐glucanase CMCax required for cellulose biosynthesis (2006)

Previous studies have demonstrated that endoglucanase is required for cellulose biosynthesis both in bacteria and plants. However, it has yet to be elucidated how the endoglucanases function in the mechanism of cellulose biosynthesis. Here we describe the crystal structure of the cellulose biosynthesis-related endo-beta-1,47-glucanase (CMCax; EC 3.2.1.4) from the cellulose-producing Gramnegative bacterium, Acetobacter xylinum (= Gluconacetobacter xylinus), determined at 1.65-A resolution. CMCax falls into the glycoside hydrolase family 8 (GH-8), and the structure showed that the overall fold of the CMCax is similar to those of other glycoside hydrolases belonging to GH-8. Structure comparison with Clostridium thermocellum CelA, the best characterized GH-8 endoglucanase, revealed that sugar recognition subsite +3 is completely missing in CMCax. The absence of the subsite +3 leads to significant broadness of the cleft at the cellooligosaccharide reducing-end side. CMCax is known to be a secreted enzyme and is present in the culture medium. However, electron microscopic analysis using immunostaining clearly demonstrated that a portion of CMCax is localized to the cell surface, suggesting a link with other known membrane-anchored endoglucanases that are required for cellulose biosynthesis.
Ozone Oxidation of Sulfides and Sulfoxides (1959)

The stepwise oxidation of organic sulfides to sulfoxides and sulfones with ozone is reported. In the case of carboxymethylmercaptosuccinic acid, it is the only successful oxidation to the sulfoxide known. The yields in most cases are essentially quantitative with respect to both the sulfur compound and ozone.
Capacitance Sensor for Nondestructive Measurement of Moisture Content in Nuts and Grain (2006)

This paper presents a portable electrical instrument that measures the complex impedance of a parallel-plate capacitor with a sample of peanut kernels between its plates. The measured values were used in an empirical equation to estimate the moisture content (mc) of the sample. The estimated values were in good agreement with the mc values obtained by standard air-oven method. This method can be used to estimate them in other types of nuts and grain by calibrating the instrument using samples of these materials with known mc values. This instrument would be useful in the grain industry for quick and nondestructive mc measurement
A Note on the Paper “Analysis, Results, and Interpretation for Radiation Between Some Simply Arranged Gray Surfaces” (1963)

Technical Briefs A Note on the Paper “Analysis, Results, and Interpretation for Radiation Between Some Simply Arranged Gray Surfaces” Frederick A. Costello Frederick A. Costello Thermodynamics, Missile and Space Division, General Electric Company, Philadelphia, Pa. Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information Frederick A. Costello Thermodynamics, Missile and Space Division, General Electric Company, Philadelphia, Pa. J. Heat Transfer. May 1963, 85(2): 183-184 (2 pages) https://doi.org/10.1115/1.3686052 Published Online: May 1, 1963 Article history Received: November 12, 1962
Deducing the stage of origin of Wilms' tumours from a developmental series of <i>Wt1</i> mutants (2015)

Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour suppressor gene. Here, we describe a developmental series of mouse models with conditional loss of Wt1 in different stages of nephron development before and after the mesenchymal-to-epithelial transition (MET). We demonstrate that Wt1 is essential for normal development at all kidney developmental stages under study. Comparison of genome-wide expression data from the mutant mouse models with human tumour material of mutant or wild-type WT1 datasets identified the stage of origin of human WT1-mutant tumours, and emphasizes fundamental differences between the two human tumour groups due to different developmental stages of origin.