gebhart/patrepeval huggingface dataset:
Realising a Flemish government innovation information portal with Business Semantic Management. (2010)

The knowledge economy is one of the cornerstones of our society. Knowledge unlocks innovation, which in turns spawns new products or services, thereby enabling further economic growth. Hence, an information system unlocking scientific technical knowledge is an important asset for government policy and strategic decisions by industry. In this paper, some pilot experiments are presented on how business semantics man- agement and related tools are applied to set up a syntactically and semantically stable conceptual modelling environment that caters for an easy and flexible extension of conceptual models by non tech-savvy domain experts. The context of the FRIS serves as use case for initial experiments. Even if such an endeavour is shown to be feasible - and leading to cost reduction - many hurdles - in particular data quality control at the input source - still need to be overcome.
Antisense miR-132 blockade via the AChE-R splice variant mitigates cortical inflammation (2017)

MicroRNA (miR)-132 brain-to-body messages suppress inflammation by targeting acetylcholinesterase (AChE), but the target specificity of 3'-AChE splice variants and the signaling pathways involved remain unknown. Using surface plasmon resonance (SPR), we identified preferential miR-132 targeting of soluble AChE-R over synaptic-bound AChE-S, potentiating miR-132-mediated brain and body cholinergic suppression of pro-inflammatory cytokines. Inversely, bacterial lipopolysaccharide (LPS) reduced multiple miR-132 targets, suppressed AChE-S more than AChE-R and elevated inflammatory hallmarks. Furthermore, blockade of peripheral miR-132 by chemically protected AM132 antisense oligonucleotide elevated muscle AChE-R 10-fold over AChE-S, and cortical miRNA-sequencing demonstrated inverse brain changes by AM132 and LPS in immune-related miRs and neurotransmission and cholinergic signaling pathways. In neuromuscular junctions, AM132 co-elevated the nicotinic acetylcholine receptor and AChE, re-balancing neurotransmission and reaching mild muscle incoordination. Our findings demonstrate preferential miR-132-induced modulation of AChE-R which ignites bidirectional brain and body anti-inflammatory regulation, underscoring splice-variant miR-132 specificity as a new complexity level in inflammatory surveillance.
A 25-MS/s 14-b 200-mW /spl Sigma//spl Delta/ Modulator in 0.18-/spl mu/m CMOS (2004)

The design of a fifth-order 4-b quantizer single-loop /spl Sigma//spl Delta/ modulator is presented that achieves 25-MS/s conversion rate with 84 dB of dynamic range and 82 dB of signal-to-noise ratio. Implemented in a 0.18-/spl mu/m CMOS technology, the 0.95-mm/sup 2/ chip has a power consumption of 200 mW from a 1.8-V supply.
Spin of a Nanotech Spin‐Off (2012)

Abstract Innovation in advanced technology often springs from ideas birthed in universities yet the attitudes of professors and their students towards entrepreneurship and their stance on the collision between fundamental research in the pursuit of knowledge and applied research directed to the creation of intellectual property, inventions, companies, jobs, products, and wealth, is not that well appreciated either inside or outside our universities. In this article I will explore this interesting issue and try to gain some insight into the challenges faced by professors confronted by the challenge of transforming basic science and engineering knowledge into products in the market place, using nanotechnology as a case study. While the specific focus of this article is on nanotechnology, more generic issues are also raised that relate to transformational business development and entrepreneurship in society and universities in a larger sense.
LIGHT and IL-1β contribute to airway remodeling in a mouse model of recurrent rhinovirus infection (2016)

Abstract Airway remodeling is defined by several structural changes including mucus metaplasia, increased peribronchial smooth muscle thickness and subepithelial fibrosis. Rhinoviruses (RVs) have been demonstrated to upregulate many airway inflammatory and remodeling factors that are implicated in the pathogenesis of asthma. Studies from our lab previously identified a tumor necrosis factor family member, LIGHT (TNFSF14), as an essential mediator of airway remodeling in an allergen-driven mouse model of severe asthma. In the present study, we examined effect of RV infection on induction of LIGHT and airway remodeling. We observed increased LIGHT mRNA after RV infection in an A549 cell line as well as in vivo after infection in the lung, and furthermore neutrophils were found to be another potential source of LIGHT. Recurrent infection of RV induced salient features of airway remodeling resembling those found in severe asthmatics. LIGHT−/− mice showed reduced neutrophilia and impairment in fibrosis and smooth muscle mass and lung collagen. Blocking LIGHT signaling with LTβRFc also inhibited subepithelial fibrosis and smooth muscle thickness. Recurrent infection of RV in the presence of house dust mite allergen further exacerbated the smooth muscle thickness and subepithelial fibrosis and this was again significantly reduced in LIGHT−/− mice. Recurrent infection of RV also induced IL-1β mRNA and neutralizing IL-1β signaling further reduced the subepithelial collagen deposition and smooth muscle thickness. This study extends our present knowledge of how viruses might cause worsening of allergic airway inflammation and promote airway remodeling in asthma by identifying LIGHT and IL-1β as being active during the response to rhinovirus.
ChemInform Abstract: A New Synthetic Approach to the Clinically Useful, anti‐HIV‐Active Nucleoside, 9‐(2,3‐Dideoxy‐2‐fluoro‐β‐D‐threo‐pentofuranosyl)adenine (β‐FddA). Introduction of a 2′‐β‐Fluoro Substituent via Inversion of a Readily Obtainable 2′‐α‐Fluoro Isomer. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Impact analysis of a flexible air transportation system: Clip-Air (2013)

Clip-Air better utilizes the capacity More passengers... ..
Thermal and photochemical reactivity of group VI open-mode bimetallic complexes based on a binucleating hexaphosphine ligand system. Crystallographic characterization of a novel ditungsten heptacarbonyl pentaphosphine compound (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal and photochemical reactivity of group VI open-mode bimetallic complexes based on a binucleating hexaphosphine ligand system. Crystallographic characterization of a novel ditungsten heptacarbonyl pentaphosphine compoundSuzanne E. Saum, Frank R. Fronczek, Scott A. Laneman, and George G. StanleyCite this: Inorg. Chem. 1989, 28, 10, 1878–1884Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/ic00309a022https://doi.org/10.1021/ic00309a022research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Divisive Gaussian Processes for Nonstationary Regression (2014)

Standard Gaussian process regression (GPR) assumes constant noise power throughout the input space and stationarity when combined with the squared exponential covariance function. This can be unrealistic and too restrictive for many real-world problems. Nonstationarity can be achieved by specific covariance functions, though prior knowledge about this nonstationarity can be difficult to obtain. On the other hand, the homoscedastic assumption is needed to allow GPR inference to be tractable. In this paper, we present a divisive GPR model which performs nonstationary regression under heteroscedastic noise using the pointwise division of two nonparametric latent functions. As the inference on the model is not analytically tractable, we propose a variational posterior approximation using expectation propagation (EP) which allows for accurate inference at reduced cost. We have also made a Markov chain Monte Carlo implementation with elliptical slice sampling to assess the quality of the EP approximation. Experiments support the usefulness of the proposed approach.
Hybridization Histochemistry of Neural Transcripts (2018)

Abstract This unit presents protocols to locate RNA transcripts in tissues. Numerous approaches are detailed, including those that use radiolabeled or colorimetric probes. Also, the probes may be modified oligodeoxynucleotides, singly or in pairs, as well as ribonucleic acids. High sensitivity and specificity are obtained, especially with sets of oligodeoxynucleotide pairs. © 2018 by John Wiley & Sons, Inc.
Use of Genetic Algorithms To Improve Partial Least Squares Fuel Property and Synthetic Fuel Modeling from Near-Infrared Spectra (2010)

Partial least-squares (PLS) regression models can be constructed from near-infrared (NIR) spectroscopic data to predict critical specification properties of jet and diesel fuels for quality surveillance. This same approach has also been used to identify Fischer−Tropsch (FT) synthetic fuels and predict their quantities in blends with jet or diesel petroleum-derived fuels at concentrations as low as 15% with a sequential modeling approach. The present work expands on these previous results using genetic algorithms to select the maximally useful subset of all available training data for both fuel property modeling and FT fuel identification purposes. Prediction improvements primarily stem from the ability of the automated genetic algorithm and F-test algorithm to select larger numbers of latent variables without overfitting, which is not possible by simply modifying the F-test threshold. These improved data subsets provide significant improvements in the precision of PLS property modeling, as well as the lower detection limit of 10% for FT fuels in blends with conventional petroleum-derived fuels. This provides the means to extend the development of predictive PLS models to detect, quantify, and predict many specification properties of FT fuels, neat and in blends with petroleum fuels. Additionally, the use of genetic algorithms now makes the detection and discrimination of FT fuels in blends with multiple FT fuels feasible with the same 10% limit of detection.
Imperfect Information Flow of Agents Communication in Arrow Logic (2020)

This paper formalizes the communication of agents with modal operators in arrow logic. A communication between agents consists of an agent's utterance and the other agent's perception, thus, both of the utterance and the perception are regarded as parts of a communication channel between agents. Information is regarded as a propositional content of a sentence. An information channel where information flows can be considered to be a program, in the sense that it gets an utterance as an input and puts an output to be a perception of some agent. In the real situations, th ere are so called miscommunications. Thus, the communication channel as a program may add some noise on information indeterministically. We implement the noises are some modal operators on information. We try to formalize the communication channels in arrow logic. In that, we especially pay attention to the following three problems: channel bottleneck, unreliable channel, and reverse information. This paper's contribution is two-fold. First, we formalize the theory of information flow, based on situation semantics, in terms of arrow logic. Secondly, we propose the theory of communication channels between agents by using arrow logic, where, classical modal operators like knowledge, belief, and perception are distributed on various places on the communication channel. We discuss the satisfiability and the applicability of our formalization, using the test principles by Barwise on this information flow model.
Peroral Intestinal Biopsy in Children: A Technique (1964)

Peroral small intestinal biopsy is an important diagnostic tool in cases of chronic diarrhea and steatorrhea. Biopsy tissue has also been used for enzyme assay to confirm the deficiency of disaccharidases as a cause of diarrhea.<sup>1</sup> A useful peroral biopsy technique for pediatric patients should combine safety, simplicity, ease of passage in infants and small children, minimal x-ray exposure, and efficiency in obtaining an adequate specimen. Because of the variation in duodenal mucosa in normal children,<sup>2,3</sup>the instrument should preferably reach the jejunum or fourth portion of the duodenum. In this report a technique for the passage of the Crosby intestinal biopsy capsule into the jejunum of infants and small children is described. Successful uncomplicated biopsies were performed on 48 occasions in 29 patients. <h3>Material and Methods</h3> The study group was composed of 32 children with chronic diarrhea of various etiologic types, including bacterial, parasitic, and tropical sprue.
DC power-bus noise isolation with power-plane segmentation (2003)

Power-plane segmentation is often used for DC power-bus noise isolation in multilayer printed circuit board (PCB) designs. To achieve a desirable noise isolation, different power-plane segmentations can be used. A suitable modeling approach, as well as measurements, were employed in this work to study the noise isolation with several power-plane segmentation designs. The geometries studied include power islands, and totally segmented power planes. The effects of the power-bus noise isolation with different types of power island connections, locations of segmentation, and shapes were analyzed, and compared. The modeled and measured results show that suitable power-plane segmentation can result in significant power-bus noise isolation.
Complex dynamics of a dc glow discharge tube: Experimental modeling and stability diagrams (2015)

We report a detailed experimental study of the complex behavior of a dc low-pressure plasma discharge tube of the type commonly used in commercial illuminated signs, in a microfluidic chip recently proposed for visible analog computing, and other practical devices. Our experiments reveal a clear quasiperiodicity route to chaos, the two competing frequencies being the relaxation frequency and the plasma eigenfrequency. Based on an experimental volt-ampere characterization of the discharge, we propose a macroscopic model of the current flowing in the plasma. The model, governed by four autonomous ordinary differential equations, is used to compute stability diagrams for periodic oscillations of arbitrary period in the control parameter space of the discharge. Such diagrams show self-pulsations to emerge remarkably organized into intricate mosaics of stability phases with extended regions of multistability (overlap). Specific mosaics are predicted for the four dynamical variables of the discharge. Their experimental observation is an open challenge.
Floor Control for Activity Coordination in Networked Multimedia Applications (1995)

Abstract { Collaboration in networked multimedia applications requires means to coordinate the activities of a dynamically aggregating set of distributed users, working with various multimedia data on heterogeneous platforms. A oor denotes a control right over a shared resource within a collaborative workspace. Floor control, similar to concurrency control for databases, is gradually being integrated into shared applications to orchestrate the access and dynamic process of joint work on shared data, supporting or substituting a human conference chair. This paper presents a comprehensive view on oor control, analyzing requirements for protocols with respect to the variety of shared tools, describing an architecture to meet these requirements, and nally placing our work in the context of previous e orts.
Convenient Synthesis of Dibenzo[<i>a</i>,<i>h</i>]anthracenes and Picenes via C–H Arylation of Acetophenones with Arenediboronates (2011)

Abstract A new convenient method for the synthesis of dibenzo[a,h]anthracenes and picenes using ruthenium-catalyzed regioselective C–H arylation of aromatic ketones has been developed. Acetophenone derivatives and 1,4-benzenediboronates were coupled in 2:1 ratios to form p-terphenyl derivatives. Conversion of the acetyl group to an ethynyl group, followed by cycloaromatization provided the desired fused aromatic compounds. An organic field-effect transistor fabricated from one of these products gave moderate hole mobility.
A method for designing and analyzing interaction design at earlier phases of the design process - use of the scenario, performance, and description format (2002)

In this study, we explored a set of methodologies that can be used at earlier phases of the design process, for designing and analyzing interaction design. Our methodology features a prototyping method that adopts performance technique, an observation method using video from the view of a user and a view that includes the system as a whole, and a method for describing interaction scenarios. Our method aimed to use the scenario and performance as techniques for communicating new design concepts and sharing experiences between designers and users, and to promote interaction between the user community and the design team. We enacted two case studies regarding the adaptation of the methodology. In one case a designer role-played a user, and in another case real users enacted the performances. We evaluated and confirmed the effectiveness of the methodology through these practices.
Control of Polymer Solution Structure via Intra- and Intermolecular Aromatic Stacking (1999)

Anthracene-functionalized polymer 1 folds into a compact globular structure in nonpolar media. This folding arises from intramolecular aromatic−aromatic interactions of the anthracene side chains. Polymer 1 binds strongly to picric acid (2), through donor−acceptor electrostatic interactions between the electron-rich anthracene side chains and the electron-deficient picric acid guests. This binding stabilizes the thermally labile folded conformation of polymer 1, dramatically altering the temperature dependence of polymer unfolding.
Inhibition of protein aggregation <i>in vitro</i> and <i>in vivo</i> by a natural osmoprotectant (2006)

Small organic molecules termed osmolytes are harnessed by a variety of cell types in a wide range of organisms to counter unfavorable physiological conditions that challenge protein stability and function. Using a well characterized reporter system that we developed to allow in vivo observations, we have explored how the osmolyte proline influences the stability and aggregation of a model aggregation-prone protein, P39A cellular retinoic acid-binding protein. Strikingly, we find that the natural osmolyte proline abrogates aggregation both in vitro and in vivo (in an Escherichia coli expression system). Importantly, proline also prevented aggregation of constructs containing exon 1 of huntingtin with extended polyglutamine tracts. Although compatible osmolytes are known to stabilize the native state, our results point to a destabilizing effect of proline on partially folded states and early aggregates and a solubilizing effect on the native state. Because proline is believed to act through a combination of solvophobic backbone interactions and favorable side-chain interactions that are not specific to a particular sequence or structure, the observed effect is likely to be general. Thus, the osmolyte proline may be protective against biomedically important protein aggregates that are hallmarks of several late-onset neurodegenerative diseases including Huntington's, Alzheimer's, and Parkinson's. In addition, these results should be of practical importance because they may enable protein expression at higher efficiency under conditions where aggregation competes with proper folding.
A Study of the Gas Liquid Partition Coefficients of Eleven Normal, Branched and Cyclic Alkanes in Sixty Nine Common Organic Liquids: The Effect of Solute Structure (2002)

Literature data measured by the author have been processed to report on the effect of solute structure on gas liquid partition coefficients of eleven normal, branched and cyclic alkanes ranging in carbon number from five to nine in sixty nine low molecular weight liquids. The alkane solutes are n-pentane(p), n-hexane(hx), n-heptane(hp), n-octane(o), n-nonane(n), 2-methylpentane(mp), 2,5-dimethylpentane(dp), 2,5-dimethylhexane(dh), 2,3,4-trimethylpentane(tp), cyclohexane(ch), and ethylcyclohexane(ec). The solvent set encompasses most of those studied by Rohrschneider as well as three homologous series of solvents (n-alkanes, 1-alcohols and 1-nitriles) and several perfluorinated alkanes and highly fluorinated alcohols. An excellent linear relationship was observed between lnK and the carbon number of n-alkanes. The effective carbon numbers of branched and cyclic alkanes were determined in a similar fashion to the method of Kovats index. We found that the logarithm of solute vapor pressure multiplied by solute molar volume was a perfect descriptor for the linear relationship with the median effective carbon number.