gebhart/patrepeval huggingface dataset:
Monitoring of Heparin Treatment. Comparison between Thrombin Time, Activated Partial Thromboplastin Time, and Plasma Heparin Concentration, and Analysis of the Behavior of Antithrombin III (1980)

Three laboratory methods for monitoring heparin treatment have been compared using 63 plasma samples: the thrombin time, the activated partial thromboplastin time, and the measurement of the heparin concentration using a chromogenic substrate. A good correlation was found between the methods. However, the intensity of anticoagulation was identical in only 27 of the 63 samples (43%) when the thrombin time and the activated partial thromboplastin time were compared. Fully discordant results were recorded for four samples (6%). The thrombin time was found to be more closely related to the plasma heparin concentration than was the activated partial thromboplastin time. Both antithrombin-III activity and immunologic levels were lower in the group with strong heparinization. It is suggested that the thrombin time is a good and safe method for monitoring heparin treatment.
Durability testing of an elastomeric foam for use in hydraulic accumulators (1988)

Etude experimentale sur banc d'essai de l'influence de l'âge d'un caoutchouc mousse de polyester-urethane injecte du cote gaz d'un accumulateur hydraulique, de son exposition a long terme a de l'azote gazeux a haute pression et de la frequence des cycles sur l'efficacite de l'accumulateur. Cette etude permet aussi de detecter les problemes de fonctionnement dus au caoutchouc mousse.
Heart failure alters matrix metalloproteinase gene expression and activity in rat skeletal muscle (2006)

Heart failure is associated with a skeletal muscle myopathy with cellular and extracellular alterations. The hypothesis of this investigation is that extracellular changes may be associated with enhanced mRNA expression and activity of matrix metalloproteinases (MMP). We examined MMP mRNA expression and MMP activity in Soleus (SOL), extensor digitorum longus (EDL), and diaphragm (DIA) muscles of young Wistar rat with monocrotaline-induced heart failure. Rats injected with saline served as age-matched controls. MMP2 and MMP9 mRNA contents were determined by RT-PCR and MMP activity by electrophoresis in gelatin-containing polyacrylamide gels in the presence of SDS under non-reducing conditions. Heart failure increased MMP9 mRNA expression and activity in SOL, EDL and DIA and MMP2 mRNA expression in DIA. These results suggest that MMP changes may contribute to the skeletal muscle myopathy during heart failure.
Managing light in nonlinear disordered media (2013)

We discuss different aspects of nonlinear effects in quadratic photonic structures with disordered domain distribution and random size. These kinds of materials with an irregular nonlinear multi-domain structure enables simultaneously phase matching mechanism of various parametric processes over an ultra-broad spectral range and in different spatial directions. The specific features of disordered domain structure greatly affect the emission pattern of the generated harmonics and thus. The recorded second harmonic pattern characterizes the size and degree of disorder in nonlinear photonic structures. On the other side, the transverse second harmonic generation, possible in these materials, provides a simple and robust single-shot method for ultrashort optical pulse characterization, which enables not only the estimation of the temporal width of the pulses but also the observation of their temporal evolution during propagation.
[Evaluation of the effect of ilaprazole on intragastric pH in patients with duodenal ulcer]. (2010)

Ilaprazole has a strong effect on intragastric acid control with a dose dependent trend.
Distributed Bragg reflector fiber laser fabricated by femtosecond laser inscription (2006)

A femtosecond laser inscription technique is proposed for the fabrication of a fiber grating laser directly into a nonphotosensitive gain fiber. A distributed Bragg reflector fiber grating laser is realized in a conventional, untreated Er:Yb-codoped fiber as an illustration. Robust, single-mode, single-polarization laser operation at temperatures in excess of 600 degrees C is further achieved without compromising performance. A nonlinear, thermally induced wavelength shift is also observed at elevated temperatures.
Treatment of New World cutaneous leishmaniasis – a systematic review with a meta‐analysis (2008)

Although pentavalent antimonials are the drugs of choice in the treatment of CL, pentamidine showed similar results. Nevertheless, several aspects, such as cost, adverse effects, local experience, and availability of drugs to treat CL, must be considered when determining the best management of this disease, especially in developing countries where resources are scarce.
Response Art: The Art of the Art Therapist (2012)

Abstract Response art is artwork created by art therapists in response to material that arises in their therapy work. Art therapists use response art to contain difficult material, express and examine their experiences, and share their experiences with others. In this viewpoint, some of the varied uses of response art are discussed and illuminated with vignettes as part of an ongoing dialogue on how dedication to art making can effectively support one's practice in a profession that recognizes the versatility and power of images.
Automatic Generation Of Subway Directions: Salience Gradation As A Factor For Determining Message And Form (1998)

A frequently encountered problem in urban life is navigation. In order to get to some place we use private means or public transportation, and if we lack clear directions we tend to ask for help. We will deal in this paper with the descriptions of subway routes and their automatic generation. In particular, we will try to show how the relative importance of a given piece of information can effect not only the message but also the form. 1 Introduction: the problem A frequently encountered problem in urban life is the use of public transportation: we have to get from here to there and quite so often we don&apos;t know how. As it is not always possible to get help from a person (be it because nobody is available, or able to speak our language), we might appreciate assistance of a machine. In order to convey to the user &quot;useful information&quot;, we must define what &quot;usefulness&quot; means. For example, if we tell someone how to get from one place to another, we hardly ever specify all the intermediate ...
Environmental influence on reproductive health (2000)

A rise in industrialization and the consequent environmental pollution, an increase in the use of synthetic chemicals and repeated exposure to hazardous compounds at the workplace and at home adversely affects reproductive health. Biohazardous compounds, some of which act as endocrine disrupters, are being increasingly implicated in infertility, menstrual irregularities, spontaneous abortions, birth defects, endometriosis and breast cancer. In some cases, women are at a greater risk than men, especially with the rise in environmental estrogens. Only a fraction of these chemicals have been adequately examined for toxicity and for synergistic effects due to multiple exposures. There is a need for a greater awareness and vigilance of the effects of environmental pollution on reproductive health.
<p>MiR-223-3p targeting epithelial cell transforming sequence 2 oncogene inhibits the activity, apoptosis, invasion and migration of MDA-MB-468 breast cancer cells</p> (2019)

MiR-223-3p targets and inhibits the expression of ECT2, thus inhibiting the invasion and migration of BC cells, and promoting cell apoptosis. miR-223-3p plays a protective role in BC.
Inhibition of cell proliferation by interleukin-1 derived from monocytic leukemia cells. (1986)

Growth inhibitors and interleukin-1 (IL-1) are two biological response modifiers produced by mezerein-treated THP-1 cells maintained in serum-free medium. The activities comigrated with isoelectrofocusing in a pH range of 6.7 to 7.3. Subsequent molecular sieving on an AcA-54 column revealed that a portion of the growth-inhibitory activity for the mammary cell line MCF-7 remained associated with IL-1. IL-1-containing fractions were further analyzed by chromatography with DEAE-Sephacel, phenyl:Sepharose, and concanavalin A:Sepharose. In each instance, IL-1 coeluted with growth-inhibitory activity. IL-1 and growth-inhibitory activities partially purified by sequential isofocusing, AcA-54 chromatography, and DEAE-Sephacel were located in a single region following preparative polyacrylamide gel electrophoresis. Elution, concentration, and analytical polyacrylamide gel electrophoresis of this region resulted in a single band with an apparent molecular weight of 17,000. Stability studies revealed similarities between the IL-1 activity and growth-inhibitory activity in their sensitivity to a variety of physical and chemical treatments. A commercial source of human IL-1 also inhibited the growth of MCF-7 cells. DEAE-purified IL-1 derived from THP-1 cells inhibited the growth of 7 of 11 cell types tested, and all inhibited cell lines were established from malignant sources. Prostaglandin synthesis by MCF-7 cells in response to IL-1 was not responsible for growth inhibition.
Validation of a severity index in female urinary incontinence and its implementation in an epidemiological survey. (1993)

The severity index may be a useful tool for assessing the severity of female urinary incontinence in epidemiological surveys. It is confirmed that urinary incontinence is very prevalent in adult women, but most should not be regarded as potential patients.
Submicrometer salicide CMOS devices with self-aligned shallow/deep junctions (1989)

The use of triple-layer oxide/nitride/PETEOS (plasma-enhanced TEOS) gate spacer, CMOS (T-MOS) structure to form shallow/deep junctions with the deep junction self-aligned to the silicide layer on the source/drain area of submicrometer CMOS devices is discussed. Due to the disposable PETEOS spacer layer, only two masks (one for each channel) are needed to form this source/drain junction signature. A T-MOS structure of 0.5- mu m physical gate length has been demonstrated with good device characteristics and ideal junction leakage properties. This T-MOS process, with its moderated doped drain (MDD) structure, is a promising device choice for deep-submicrometer CMOS devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Technology of accelerated processing of rough plant raw material and waste (2016)

Analysis of domestic and foreign experience in obtaining of high-protein feed additives allowed to identify the most important technology and equipment for these purposes. It was revealed that traditional methods of preparation of these feed additives mostly include single-stage chopping and mixing. This is not enough for obtaining of homogeneous granulometric composition of high-quality mixture. The equipment in use has high energy and metal intensity. As a result of the study, innovative equipment is proposed, and physical models are made. The article suggests to use new effective methods of three-stage chopping of plant raw material and its transportation, as well as food waste grinding and two-stage mixing in aqueous media for obtaining homogeneous product. It is recommended to manufacture the equipment in modular construction, that allows to compose the series-produced technical means with new less energy-intensive ones for use on flow line. The main parameters of equipment operating modes are determined. The developed technical means involve the fundamentally new working organs, that provide three-stage chopping of low-value plant materials, their transportation and two-stage mixing with the use of adjustable blades. Such processing of raw material improves the performance characteristics of equipment, and allows to increase the production profitability in comparison with best foreign and domestic equivalents. For supplying of control systems with innovative technologies and equipment, it is recommended to use computer control system, created on the basis of mechatronic systems. Creation of equipment control system and application of new methods of chopping and mixing of rough plant and food waste allow to increase the performance of entire line by 35%, reduce the material and energy intensity by 34-40% with a payback period of 9 months.
COSTLY SHORT SALES AND THE CORRELATION OF RETURNS WITH VOLUME (1988)

Abstract Previous researchers have documented an empirical correlation between returns and trading volume in some financial markets. In this paper, an explanation is proposed based on the notion that short positions are more costly than long positions in these markets. The hypothesis is consistent with previous findings and with futures markets data, in which the costs of assuming short and long positions are symmetric and in which the correlation between returns and volume is not significant.
Platelet Concentrates from Automated Apheresis – Past, Present and Future Developments (2000)

The preparation of platelet concentrates by automated apheresis started in the early 1970s. Originally intended to increase the amount of platelets from selected (HLA compatible) donors to supply HLA-immunized patients, plateletpheresis has permanently expanded. Further development of plateletpheresis is described. Considering medical and economical perspectives, actual trends and possible future developments of plateletpheresis are discussed.
Fall Detection Using Smartphone Audio Features (2015)

An automated fall detection system based on smartphone audio features is developed. The spectrogram, mel frequency cepstral coefficents (MFCCs), linear predictive coding (LPC), and matching pursuit (MP) features of different fall and no-fall sound events are extracted from experimental data. Based on the extracted audio features, four different machine learning classifiers: k-nearest neighbor classifier (k-NN), support vector machine (SVM), least squares method (LSM), and artificial neural network (ANN) are investigated for distinguishing between fall and no-fall events. For each audio feature, the performance of each classifier in terms of sensitivity, specificity, accuracy, and computational complexity is evaluated. The best performance is achieved using spectrogram features with ANN classifier with sensitivity, specificity, and accuracy all above 98%. The classifier also has acceptable computational requirement for training and testing. The system is applicable in home environments where the phone is placed in the vicinity of the user.
Activation of human beta-glucuronidase by murine monoclonal antibodies and bovine serum albumin in an uncompetitive fashion. (1995)

Catalytic antiidiotypic antibodies exhibit enzyme activity because they possess the internal image of the enzyme that serves as the antigen. However, we have found that non-catalytic monoclonal antibodies specific for human beta-glucuronidase and, to a lesser extent, bovine serum albumin were capable of enhancing the activity of this enzyme. The stability of the enzyme was not increased by these proteins. Enzyme kinetic studies revealed an uncompetitive activation mechanism with a proportional increase in both maximal velocity and Michaelis constant of the enzyme with the increase in the protein concentration. These three proteins apparently bound to the enzyme with subsequent alteration of its affinity for the substrate. Activation of the enzyme by its non-catalytic antibody might not be a rare occurrence and it could play a pathogenic role in certain disease processes.
Score-Aging Calibration for Speaker Verification (2016)

The gradual changes that occur in the human voice due to aging create challenges for speaker verification. This study presents an approach to calibrating the output scores of a speaker verification system using the time interval between comparison samples as additional information. Several functions are proposed for the incorporation of this time information, which is viewed as aging information, in a conventional linear score calibration transformation. Experiments are presented on data with shortterm aging intervals ranging between 2 months and 3 years, and long-term aging intervals of up to 30 years. The aging calibration proposal is shown to offset the decreased discrimination and calibration performance for both shortand long-term intervals, and to extrapolate well to unseen aging intervals. Relative reductions in Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ℓℓr</sub> (cost of log-likelihood ratio) of 1-4% and 10-43% are obtained at shortand long-term intervals, respectively. Assuming that a system has knowledge of the time interval between samples under comparison, this approach represents a straightforward means of compensating for the detrimental impact of aging on speaker verification performance.
Imaging dopamine transmission in schizophrenia. A review and meta-analysis. (1998)

Over the last ten years, several positron emission tomography (PET) and single photon computerized tomography (SPECT) studies of the dopamine (DA) system in patients with schizophrenia were performed to test the hypothesis that DA hyperactivity is associated with this illness. In this paper, we reviewed the results of fifteen brain imaging studies comparing indices of DA function in drug naive or drug free patients with schizophrenia and healthy controls: thirteen studies included measurement of DA D2 receptors density, two studies compared amphetamine-induced DA release, and two studies measured DOPA decarboxylase activity, an enzyme involved in DA synthesis. We conducted a meta-analysis of the studies measuring D2 receptor density parameters, under the assumption that all tracers labeled the same population of D2 receptors. This analysis revealed that, compared to healthy controls, patients with schizophrenia present a significant but mild elevation of D2 receptor density parameters and a significant larger variability of these indices. We found no statistical evidence that studies performed with radiolabeled butyrophenones detected a larger increase in D2 receptor density parameters than studies performed with other radioligands, such as benzamides. Studies of presynaptic activity revealed an increase in DA transmission response to amphetamine challenge, and an increase in DOPA decarboxylase activity. Together, these data are compatible with both pre- and post-synaptic alterations of DA transmission in schizophrenia. Future studies should aim at a better characterization of these alterations, and at defining their role in the pathophysiology of the illness.
Error analysis and data forecast in the centre of gravity measurement system for small tractors (2011)

A novel centre of gravity measurement system for small tractors with the principle of the three-point reaction is presented. According to the prototype of a small tractor gravity centre test platform, a mathematic multi-body dynamics prototype was built to analyze the measurement error in the centre of gravity measurement system. For the precision evaluation, interrelationships among the factors were studied which included the test platform structural parameters, the error of measurement sensors and the displacement of drive-pillar and the mass of measurement object. In succession, a virtual collaborative model of the centre of gravity measurement system was built and verified by a real prototype-based measurement platform. A modified gray model GM(1,1), which was used for forecasting the gravity height of small tractors, was proposed to avoid deviation of test data and so improved the measurement accuracy. A series of standard test object experiments were carried out, and the results showed that the relative error of the gravity height was up to 0.93%
Use of covariance analysis for the prediction of structural domain boundaries from multiple protein sequence alignments (2002)

Current methods for identification of domains within protein sequences require either structural information or the identification of homologous domain sequences in different sequence contexts. Knowledge of structural domain boundaries is important for fold recognition experiments and structural determination by X-ray crystallography or nuclear magnetic resonance spectroscopy using the divide-and-conquer approach. Here, a new and conceptually simple method for the identification of structural domain boundaries in multiple protein sequence alignments is presented. Analysis of covariance at positions within the alignment is first used to predict 3D contacts. By the nature of the domain as an independent folding unit, inter-domain predicted contacts are fewer than intra-domain predicted contacts. By analysing all possible domain boundaries and constructing a smoothed profile of predicted contact density (PCD), true structural domain boundaries are predicted as local profile minima associated with low PCD. A training data set is constructed from 52 non-homologous two-domain protein sequences of known 3D structure and used to determine optimal parameters for the profile analysis. The alignments in the training data set contained 48 +/- 17 (mean +/- SD) sequences and lengths of 257 +/- 121 residues. Of the 47 alignments yielding predictions, 35% of true domain boundaries are predicted to within 15 amino acids by the local profile minimum with the lowest profile value. Including predictions from the second- and third-lowest local minima increases the correct domain boundary coverage to 60%, whereas the lowest five local minima cover 79% of correct domain boundaries. Through further profile analysis, criteria are presented which reliably identify subsets of more accurate predictions. Retrospective analysis of CASP3 targets shows predictions of sufficient accuracy to enable dramatically improved fold recognition results. Finally, a prediction is made for geminivirus AL1 protein which is in full agreement with biochemical data, yielding a plausible, novel threading result.
Biology of the human myeloma cell population. II. Cytokinetic characteristics. (1978)

A kinetic study of five human myeloma cell populations before and after chemotherapy using cytochemical and autoradiographical techniques showed: 1. a large number of cells, with a DNA content intermediate between 2c and 4c, that did not incorporate thymidine ('U' cells) and were indicative of ineffective myelomapoiesis; 2. non cell cycle-specific (cyclophosphamide) followed by cell cycle-specific (vincristine) treatment led to an increase in the 3H-thymidine labelling index (LI) and activation of macromolecular synthesis (increased uridine and leucine uptake and actinomycin binding capacity) pointing to early cell recruitment. A high percentage of 'U' cells can be found even after therapy. The LI variations make it clear that recruitment after therapy is overestimated by at least 40% due to ineffective myelomapoiesis. In the light of this and previous personal studies, we propose a kinetic pattern: the myeloma population may be seen as a highly differentiating population whose non-proliferating cells cannot re-enter the cycle. By contrast, the acute leukemia populations are unable to differentiate, and the non-proliferating cells (G0) can be recalled into the cell cycle.