gebhart/patrepeval huggingface dataset:
Correlation of security events based on the analysis of structures of event types (2017)

The paper studies the process of correlation for SIEM systems based on analyzing the structures of security event types. The approach to automated analysis of security events as input data with dynamic content is proposed. For the automated analysis of events the paper suggests to build a graph of types of events with direct and indirect links between them. Processing of security input data means performing functional and behavioral analysis by computing the frequency-time characteristics of events, their ranking and building of patterns of behavior. The proposed approach allows to use a previously not applied method of rank correlation, alongside with other intelligent methods. The requirements to the normalization of original data are formulated. An example of the analysis of the security event log and the generated graph of event types are provided.
RX64DTH -a fully integrated 64-channel ASIC for a digital X-ray imaging system with energy window selection (2005)

We report on the multichannel IC (RX64DTH) designed for position sensitive X-ray measurements with silicon strip detectors and dedicated to medical imaging applications. This integrated circuit has a binary readout architecture with a double threshold allowing on selection energy window for measured signals. The design was realized in a 0.8 /spl mu/m CMOS process. The core of the RX64DTH IC consists of 64 readout channels. The single channel is built with four basic blocks: charge sensitive preamplifier, shaper, two independent discriminators, and two independent 20-bit counters. Each readout channel counts pulses which are above the low discriminator threshold and counts pulses independently above the high discriminator threshold. The energy resolution in such architecture is limited by the noise of a single channel and by channel to channel threshold spread. We present the noise and matching performance of a 384-channel module built with a silicon strip detector and six RX64DTH ICs. In the 384-channel module an equivalent noise charge of about 200 el. rms is achieved for the shaper peaking time of 0.8 /spl mu/s and strip capacitance of 3 pF. The deviation of discriminator thresholds for the whole system is only 87 el. rms. The obtained results show that the energy resolution and uniformity of analog parameters (noise, gain, offset) are sufficient for medical diagnostic applications such as dual energy mammography and angiography.
Strategies for Survival: Recollections of Bondage in Antebellum Virginia (2010)

Listening to Slaves in their Own Words William Dusinberre has spent the better part of his career working over a particular set of questions about the master-slave relationship. Yet reexamining the same set of questions is an improbable strategy for an accomplished scholar of intellect....
Modes of operation and radiation sensitivity of ultrathin SOI transistors (2003)

The electrical characteristics of the fully depleted SOI transistor depend to a great extent on the properties and mode of operation of the back interface. The threshold voltage of the surface MOS device can change significantly as the back interface is driven from accumulation to depletion. Elimination of the kink effect, enhancement of the inversion-layer mobility, and an improved subthreshold slope all require that the back interface be held in depletion. Shifts in MOS transistor behavior after irradiation are typically observed in threshold voltages, subthreshold slopes, transconductances, and leakage currents associated with fixed charge accumulation and fast interface state generation at silicon-oxide interfaces. The presence of an additional exposed back interface in thin, fully depleted SOI transistors suggests that charge and interface-state variations caused by radiation-induced damage at the back interface will cause additional changes in device behavior. Hence, shifts in the behavior of fully depleted SOI transistors may be greater than in those made in thick SOI films where the top surface is shielded by the neutral region of the transistor body from changes in the back interface charge.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Topography of glycosylation and UDP-xylose production (1993)

In order to define the location and organization of the numerous reactions involved in polysaccharide assembly during synthesis of proteoglycans and glycoproteins, the topography of some of the glycosylation reactions in chondroitin sulfate synthesis was examined using a relatively new technique for generating permeable cells. Permeable chondrocytes were shown to directly take up nucleotide sugar precursors and incorporate them into chondroitin sulfate proteoglycan (CSPG), allowing specific labeling at each step in chondroitin sulfate synthesis. Subcellular fractionation following labeling with UDP-[14C]xylose, UDP-[14C]galactose, UDP-[14C]glucuronic acid, or [35S]PAPS localized the labeled CSPG to the compartment where each glycosylation reaction occurred. From these experiments it appears that xylose addition begins in the endoplasmic reticulum and continues in the Golgi apparatus where galactose, glucuronic acid, and sulfate are added. This conclusion was confirmed by direct visualization of xylose incorporation using electron microscopic autoradiography (Vertel, B. M., Walters, L. M., Flay, N., Kearns, A. E., and Schwartz, N. B. (1993) J. Biol. Chem. 268, 11105-11112). Further examination of xylose addition showed that permeable chondrocytes can utilize both exogenous UDP-xylose transported into the lumen and UDP-xylose generated from UDP-glucuronic acid within the lumen. The enzyme responsible for this reaction, UDP-glucuronate carboxy-lyase, co-localized with xylosyltransferase activity in subcellular fractions. Orientation toward the lumen in subcellular compartments was determined by trypsin sensitivity in the permeable chondrocytes. Therefore, we conclude that UDP-xylose can be produced in the lumen of the compartment where it is utilized in CSPG synthesis, obviating the need for a direct transport mechanism for this nucleotide sugar and providing close regulation of UDP-xylose and UDP-glucuronic acid levels.
Vitamin B<sub>6</sub>; eine neue Synthese durch Diels‐Alder‐Reaktion (1979)

Abstract 4‐Methyloxazol ( 1a ) geht mit 3‐Methylsulfonyl‐2,5‐dihydrofuran ( 7 ) eine Diels‐Alder‐Reaktion ein, bei der unter Eliminierung von Methansulfinsäure das Pyridoxinderivat 8 entsteht. Dessen Behandlung mit Chlorwasserstoff führt zum Dichlorid 10 , aus dem durch direkte Hydrolyse oder über das Triacetat 14 Pyridoxin ( 12 ) erhalten wird. Die Reaktionsfolge stellt eine ergiebige Synthese für Vitamin B 6 dar.
Antibacterial and cytotoxic effect of ceftazidime-mitoxantrone association. (1989)

Microbial infections are a major problem in tumor-bearing and in immunocompromised patients. In such conditions it is of paramount importance to know the possible interactions between anti-tumor and antimicrobial drugs. In the present work we investigated the relationship between Ceftazidime and Mitoxantrone. Ceftazidime and Mitoxantrone were tested alone and in combination for antibacterial activity against different strains of Gram- and Gram+ bacteria. The cytotoxic effect of combination Mitoxantrone-Ceftazidime was determined in cultured P388 leukemia cells. No interference with the antibacterial activity of Ceftazidime or with the cytotoxic activity of Mitoxantrone was observed.
Anti-<i>Saccharomyces cerevisiae</i>Antibodies Are Elevated in Graves’ Disease But Not in Hashimoto’s Thyroiditis (2012)

Patients with GD had a higher frequency of ASCA IgG than controls.
Produced Water from Oil-Gas Plants: A Short Review on Challenges and Opportunities (2016)

The produced water, which could be a complex mixture of different organic and inorganic compounds (mostly salts, minerals and oils) is a major wastewater stream generated during oil and gas production processes. Due to increase oil and gas exploration and production, especially from unconventional resources like shale oil and gas reservoirs, the volume of this effluent production is increasing around the world and its discarding to the environment is one of the global concerns. There are various physical and chemical methods to treat the produced water. However, a comprehensive and deep understanding of each issue can lead to a better and more efficient solution. In this study, various physical and chemical treatment methods for produced water have been reviewed based on the latest findings and recently published articles on this topic. Moreover, challenges and opportunities of each of these treatment methods have been fully discussed. Also potential applications for reusing the treated PW have been suggested and discussed finally.
Some Experiments in Local Microcode Compaction for Horizontal Machines (1981)

Microcode compaction is an essential tool for the compilation of high-level language microprograms into microinstructions with parallel microoperations. The purpose of the research reported in this paper is to compare four microcode compaction methods reported in the literature: first-come first-served, critical path, branch and bound, and list scheduling. In order to do this a complete, machine independent method of representing the microoperations of real machines had to be developed; and the compaction algorithms had to be recast to use this representation. The compaction algorithms were then implemented and tested on microcode produced by a compiler for a high-level microprogramming language. The results of these experiments were that for all cases examined the first-come first-served and list scheduling algorithms produced microcode compacted into a minimal number of microinstructions in time that was a polynomial function of order two of the number of input microoperations.
1-naphthol-pyronin B as a novel substrate for silver intensification: application to light and electron microscopic immunocytochemistry of neuroendocrine systems. (1990)

We describe a modification of silver intensification of immunoperoxidase end-product using 1-naphthol (1N) and 1N enhanced by pyronin B after suppressing nonspecific tissue argyrophilia with a solution of penicillamine and merthiolate buffered near neutral pH. This approach facilitates the preservation of a second antigen sequentially labeled in the same tissue section for light microscopic double immunolabeling experiments and also allows retention of ultrastructural detail. Using this protocol, we obtained rapid and uniform silver intensification of somatostatin (SRIF)-immunoreactive (IR) neuronal perikarya and processes in the rat hypothalamic paraventricular nucleus (PVN). Ultrastructurally, 1N- and 1N-pyronin B-silver intensified reaction product was clearly recognized by the presence of a coarse intracellular precipitate of high electron density. Light microscopic double-immunolabeling studies demonstrated the association between SRIF- and thyrotropin-releasing hormone (TRH)-IR neuronal systems in the PVN. We propose that silver intensification of 1N and 1N-pyronin B is a useful alternative to standard methods of silver intensification of immunoperoxidase reaction product at both light and ultrastructural levels and may be particularly amenable for double-immunolabeling studies.
TPEN Induces Apoptosis Independently of Zinc Chelator Activity in a Model of Acute Lymphoblastic Leukemia and<i>Ex Vivo</i>Acute Leukemia Cells through Oxidative Stress and Mitochondria Caspase-3- and AIF-Dependent Pathways (2012)

Acute lymphoblastic leukemia is still an incurable disease with resistance to therapy developing in the majority of patients. We investigated the effect of TPEN, an intracellular zinc chelator, in Jurkat and in ex vivo acute lymphoblastic leukemia (ALL) cells resistant to chemotherapy. Changes of nuclei morphology, reactive oxygen species generation, presence of hypodiploid cells, phosphatidylserine translocation, mitochondrial membrane depolarization, immunohistochemical identification of cell death signalling molecules, and pharmacological inhibition were assayed to detect the apoptotic cell death pathways. We found that TPEN induces apoptosis in both types of cells by a molecular oxidative stress pathway involving O(2)(•-) > H(2)O(2) >> NF-κB (JNK/c-Jun) >p53> loss ΔΨ(m)> caspase-3, AIF > chromatin condensation/DNA fragmentation. Interestingly, TPEN induced apoptosis independently of glucose; leukemic cells are therefore devoid of survival capacity by metabolic resistance to treatment. Most importantly, TPEN cytotoxic effect can eventually be regulated by the antioxidant N-acetyl-cysteine and zinc ions. Our data suggest that TPEN can be used as a potential therapeutic prooxidant agent against refractory leukemia. These data contribute to understanding the importance of oxidative stress in the treatment of ALL.
ElectriC Utilities In 2007 (1998)

A c entury ago-in the year J.J . Thomson discover ed the electron-electricity, gas and tracti on companies battled for markets, and corruptcity councils demanded their fair share of the take . On e tycoon becameso d isgu sted with the confusion and dishonesty that he decid ed to bribethe legisl atur e to se t up an hon est, state-run regulat or y agenc y th atwo uld bring orde r to chaos.But he wa s fo und ou t. The scan dal set back the cause of re gulat ionunt il 1907, the year in whic h th e elect ric was hi ng m ach ine and theva cuum cleane r were inve n ted. By then, electricity sales had sep tu p ledfrom 1897 levels, an d three states had es tablished ut ility regul ati on .In the coming decade, 1997 to 2007, the ut ility business co uld un-dergo similar dra matic change, but it w ill move towar d less re gulat ionand more compe tition dur ing a period of slow gro wth . Manageme n twi ll have to wo rk h ard er to achiev e success, however, becau se mu ch ofthe p rofits will ha ve to come not from a growing mark et but f rom thepockets of compe titors .
Enantioselective synthesis of (+)‐ and (−)‐<i>cis</i>‐2‐methyl‐4‐propyl‐1,3‐oxathiane and their olfactive properties (1984)

Abstract The enantioselective synthesis of (+)‐ and (−)‐ cis ‐2‐methyl‐4‐propyl‐1,3‐oxathine 8 and 9 form ( E )‐2‐hezen‐1‐ol ( 1 ) as common starting material is described. The two enantiomeric forms exhibit different organoleptic properties.
Target genes for OBP3, a Dof transcription factor, include novel basic helix‐loop‐helix domain proteins inducible by salicylic acid (2003)

Overexpression of a salicylic-acid (SA)-inducible Arabidopsis DNA binding with one finger (Dof) transcription factor, called OBF-binding protein 3 (OBP3; AtDof3.6), has previously been shown to result in growth defects. In this study, suppressive subtraction hybridization (SSH) was used to isolate genes induced in an OBP3-overexpression line and several putative clones, called OBP3-responsive genes (ORGs), were isolated. The link with the induced expression levels of these genes and OBP3 overexpression was confirmed by analysing additional OBP3-overexpression lines. ORG1 through ORG4 are novel genes, while ORG5 is an extensin gene, AtExt1. While ORG4 has no similarity with other proteins in the database, ORG1 has weak similarity in different regions of the predicted protein with CDC2 and fibrillin. ORG2 and ORG3 share 80% overall identity in their deduced amino acid sequences and contain a basic helix-loop-helix DNA-binding domain, suggesting that ORG2 and ORG3 may be transcription factors. The expression of the ORG1, ORG2 and ORG3 genes was co-regulated under all conditions examined including upregulation by SA and downregulation by jasmonic acid (JA). Fifteen OBP3-silenced lines were generated to further explore the function of OBP3. Although there were no visible phenotypic changes in any of these lines, the expression of ORG1, ORG2 and ORG3 was reduced. Among the ORG genes, ORG1, ORG2 and ORG3 contained the highest number of potential Dof-binding sites in the promoter region, and their expression was significantly increased within 3 h after induction of OBP3 expression using an inducible promoter system, and closely reflected the expression levels of the exogenous OBP3 protein. The results from the gain-of-function and loss-of-function experiments suggest that the ORG1, ORG2 and ORG3 genes are direct target genes of OBP3.
A pro-fibrotic role for interleukin-4 in cardiac pressure overload (2012)

This study demonstrates for the first time that IL-4, most likely produced by mast cells in the heart during pressure overload, is a significant contributor to cardiac fibrosis. Targeting this cytokine may be a useful therapeutic strategy to limit cardiac fibrosis.
Huperzine A - An Interesting Anticholinesterase Compound from the Chinese Herbal Medicine (1998)

Huperzine A, alkaloid from the Chinese herbal medicine Qian Ceng Ta, which is prepared from the moss Huperzia serrata, has been used in China for centuries to treat fever and inflammation. Huperzine A is a strong inhibitor of cholinesterases with high selectivity to acetylcholinesterase and in China is developed as therapeutic against Alzheimer's disease. May be that huperzine A will be better than other centrally active anticholinesterases in treating this neurodegenerative disorder. Huperzine A appears to have additional pharmacological properties that make it an attractive candidate therapy for clinical trials.
An anisotropic topology optimization method for carbon fiber-reinforced Fused Filament Fabrication. (2016)

Topology optimization has become an increasingly important field in materials engineering for determining optimal material distribution given certain loading conditions. As the desire for stronger, lightweight structural parts grows as well as the influence of additive manufacturing in the composites industry, there is a need for determining optimal structural orientation of Fused Filament Fabrication (FFF)-produced parts, especially those that have been improved with the addition of carbon fiber to the polymer feedstock. In this work, variations of the Solid Isotropic Material with Penalization (SIMP) method for topology optimization are proposed and modified, using the Adjoint Variable Method for design sensitivity analysis, a sensitivity filter to prevent checkerboarding, and a transversely isotropic material model. Using this technique, optimizations are performed for varying x- and y- direction orientation, as well as a variable material angle. Tested FFF-produced samples show agreement with computational results.
Quinolinequinones. IV. Derivatives of 7-Hydroxy-5-8-quinolinequinone<sup>1</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuinolinequinones. IV. Derivatives of 7-Hydroxy-5-8-quinolinequinone1Yolanda T. Pratt and Nathan L. DrakeCite this: J. Am. Chem. Soc. 1957, 79, 18, 5024–5026Publication Date (Print):September 1, 1957Publication History Published online1 May 2002Published inissue 1 September 1957https://doi.org/10.1021/ja01575a052RIGHTS & PERMISSIONSArticle Views191Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (458 KB) Get e-Alertsclose Get e-Alerts
Metabolism of 8-aminoquinoline antimalarial agents. (1981)

Some of the most effective antimalarial agents are derivatives of 8-aminoquinoline. The metabolic products of many of these compounds appear to be toxic to the erythrocytes of certain human subjects, especially those deficient in glucose-6-phosphate dehydrogenase. Although a number of studies have been conducted over many years, the metabolism of most of these compounds has not been determined. These studies are reviewed.Adult dogs dosed with tritium-labelled primaquine were observed to excrete approximately 16% of the injected radioactivity in the urine within 8 hours. Organic extracts of the urine were fractionated by thin-layer chromatography and the metabolic pattern obtained. Some primaquine was excreted along with at least five metabolites including 5-hydroxy-6-methoxy-8-(4-amino-1-methylbutylamino)quinoline (5HPQ) and a small amount of 6-hydroxy-8-(4-amino-1-methylbutylamino)quinoline (6HPQ). The 5HPQ could form a quinoneimine-type compound which may be a methaemoglobin-forming compound. This and other metabolites isolated from urine were found to be active methaemoglobin formers in in vitro studies. In vitro metabolism of primaquine by mouse liver enzymes also produced compounds capable of methaemoglobin formation. One of these had a blue colour when exposed to alkaline conditions, air, and light, and mass spectral data and nuclear magnetic resonance analysis indicated a structure similar to a 5,6-dihydroxy derivative of primaquine. However, the chemical structure of the metabolite was not identified in these studies.
Terabit-per second throughput switches for broadband central offices: an overview (1990)

The design of a broadband central office (CO) switch based on the SONET standard and the asynchronous transfer mode (ATM) protocol is addressed. An overview is given of the next generation switch (NGS), which has been proposed as a functional architecture for broadband networks and switching systems. The NGS consists of a number of different functional modules (interface, control, operations, service, and fabric), interconnected by open interfaces, that together form a high-speed large-throughput switching system. The interface modules and fabric modules, which embody some of the more difficult technological problems encountered in realizing terabit-per-second switches, are examined in detail.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Circular of the Bureau of Standards no. 539 volume 4: (1955)

Barium,
Ionic Liquid Enhanced Solvent Extraction for Bitumen Recovery from Oil Sands (2011)

An ionic liquid (IL) with low viscosity, 1-ethyl-3-methyl imidazolium tetrafluoroborate ([Emim][BF4]), was used to enhance bitumen recovery from oil sands by solvent extraction using a composite solvent of n-heptane and acetone. Results demonstrated that [Emim][BF4] increased the bitumen recovery by up to 95% at room temperature. Much less clay fines in the recovered bitumen than those using solvent extraction without IL, and organic residue was not observed in the spent sands. This technology circumvented the issue of tailing water because only a small amount of water was used to recycle IL, and organic solvent could be readily regenerated by distillation. The low viscosity of [Emim][BF4] made it outperform other alternative ILs for application in the oil sand industry. Results also highlighted the role of acetone in this technology (i.e., decrease IL viscosity and reduce IL consumption). The optimal solvent extraction conditions were found to be stirring for 10 min at 450 rpm at 25 °C. The optimized ratio of acetone to n-heptane in the composite solvent and the ratio of organic solvents to oil sands was determined as 2:6 (v/v) and 4:1 (v/w), respectively.