gebhart/patrepeval huggingface dataset:
Calmodulin Binds to p21Cip1 and Is Involved in the Regulation of Its Nuclear Localization (1999)

p21(Cip1), first described as an inhibitor of cyclin-dependent kinases, has recently been shown to have a function in the formation of cyclin D-Cdk4 complexes and in their nuclear translocation. The dual behavior of p21(Cip1) may be due to its association with other proteins. Different evidence presented here indicate an in vitro and in vivo interaction of p21(Cip1) with calmodulin: 1) purified p21(Cip1) is able to bind to calmodulin-Sepharose in a Ca(2+)-dependent manner, and this binding is inhibited by the calmodulin-binding domain of calmodulin-dependent kinase II; 2) both molecules coimmunoprecipitate when extracted from cellular lysates; and 3) colocalization of calmodulin and p21(Cip1) can be detected in vivo by electron microscopy immunogold analysis. The carboxyl-terminal domain of p21(Cip1) is responsible for the calmodulin interaction, since p21(145-164) peptide is also able to bind calmodulin and to compete with full-length p21(Cip1) for the calmodulin binding. Because treatment of cells with anti-calmodulin drugs decreases the nuclear accumulation of p21(Cip1), we hypothesize that calmodulin interaction with p21(Cip1) is important for p21(Cip1), and in consequence for cyclin D-Cdk4, translocation into the cell nucleus.
Mechanism of enzyme action. Semiannual report. September 1968. (1968)

http://deepblue.lib.umich.edu/bitstream/2027.42/6956/5/bad1129.0002.001.pdf
Can a targeted psychological intervention be effective for young people following a first manic episode? Results from an 18‐month pilot study (2012)

This study suggests that a manualized psychological intervention targeted to a first-episode population can be effective in reducing depression and overall symptom severity, and can improve functional outcome following a first episode of psychotic mania.
Effect of Enoxacin, Felbinac, and Sparfloxacin on Fatty Acid Metabolism and Glucose Concentrations in Rat Tissues (2011)

Multiple changes in metabolic levels could be useful for understanding physiological toxicity. To explore further risk factors for the convulsions induced by the interaction of nonsteroidal anti-inflammatory and new quinolone antimicrobial drugs, the effect of sparfloxacin, enoxacin, and felbinac on fatty acid metabolism and glucose concentrations in the liver, brain, and blood of rats was investigated. The levels of long-chain acyl-CoAs (C(18:1) and C(20:4)) in the liver and brain were decreased at the onset of convulsions induced by the coadministration of enoxacin with felbinac. Then, glucose concentrations in the liver and blood were decreased, whereas they were increased in a dose-dependant manner in the brain. However, the formation of acyl-CoAs and glucose levels in the liver, brain, and blood was not significantly influenced by enoxacin, felbinac, and sparfloxacin alone, respectively. The disturbance of both fatty acid metabolism and glucose levels might be associated with the increased susceptibility to convulsions, which may contribute to further understanding of the toxic effects associated with these drugs.
Timetable for oral prevention in childhood—developing dentition and oral habits: a current opinion (2015)

As most of the etiologic factors of malocclusion are of genetic origin and thus cannot be prevented, environmental causative factors have become the focus for correction. Early interception of oral habits may be an important step in order to prevent occlusal disturbances in children. The identification of an abnormal habit and the assessment of its potential immediate and long-term effects on the dentition and potentially on the craniofacial complex should be made at an early stage. This paper focuses on the most common oral habits influencing dentofacial growth in childhood and management of these habits in the developing dentition.
Barium ferrite thin film media with perpendicular <i>c</i>-axis orientation and small grain size (2000)

Barium ferrite thin films with perpendicular c-axis orientation and small grain size (about 300 Å) were successfully fabricated with careful control of sputtering conditions. The c-axis orientation of barium ferrite thin films is most sensitive to the oxygen partial pressure during deposition. All samples with oxygen gas during deposition have a random c-axis texture, as indicated by existence of both weak (00l) peaks and (106) peaks. All the samples without oxygen gas during deposition show only strong (00l) peaks, which indicate excellent perpendicular c-axis orientation. Transmission electron microscopy results show that oxygen gas promotes the growth of in-plane and/or randomly oriented grains. The effect of the Pt interlayer on the barium-rich films was also studied. The Pt interlayer was found to be very effective in improving c-axis orientation of barium-rich films. A relative increase in perpendicular nucleation sites over in-plane and/or random nucleation sites contributes to the improvement in perpendicular c-axis orientation.
100 years of wine microbiology (1980)

It can be said that wine microbiology began about 100 years ago, if we think of it as being concerned mainly with alcoholic fermentation and selection of yeasts, malo-lactic fermentation and the bacteria involved, and problems with microbiological spoilage. Louis Pasteur's first edition of Etudes sur le Vin was published in 1866, and in 1889 Kulisch presented the first evidence that malo-lactic fermentation was microbiological. However, the major contributions by the University of California in wine microbiology did not begin until early in this century.
Stretching Single Talin Rod Molecules Activates Vinculin Binding (2009)

The molecular mechanism by which a mechanical stimulus is translated into a chemical response in biological systems is still unclear. We show that mechanical stretching of single cytoplasmic proteins can activate binding of other molecules. We used magnetic tweezers, total internal reflection fluorescence, and atomic force microscopy to investigate the effect of force on the interaction between talin, a protein that links liganded membrane integrins to the cytoskeleton, and vinculin, a focal adhesion protein that is activated by talin binding, leading to reorganization of the cytoskeleton. Application of physiologically relevant forces caused stretching of single talin rods that exposed cryptic binding sites for vinculin. Thus in the talin-vinculin system, molecular mechanotransduction can occur by protein binding after exposure of buried binding sites in the talin-vinculin system. Such protein stretching may be a more general mechanism for force transduction.
Balloon Dilation and Stent Placement for Esophageal Lesions: Indications, Methods, and Results (2003)

Esophageal balloon dilation and expandable stent placement are safe, minimally invasive, effective treatments for esophageal strictures and fistulas. These procedures have brought the management of dysphagia due to esophageal strictures into the field of interventional radiology. Esophageal dilation is usually indicated for benign stenoses and is technically successful in more than 90% of cases. Most patients with esophageal carcinoma are not candidates for resection; thus, the main focus of treatment is palliation of malignant dysphagia and esophagorespiratory fistulas. Esophageal stent placement, which is approved only for malignant strictures, is one of the main therapeutic options in affected patients and relieves dysphagia in approximately 90% of cases. Dedicated commercially available devices continue to evolve, each with its own advantages and limitations. Stent placement is subject to technical pitfalls, and adverse events occur following esophageal procedures in a minority of cases. Although chest pain is common and self-limited, reflux esophagitis, stent migration, tracheal compression, and esophageal perforation and obstruction require specific interventions. In many cases, these complications can be recognized and treated by the interventional radiologist with minimally invasive techniques.
[Modification of catabolic metabolism in patients with sepsis and cranio-cerebral injuries by administration of human growth hormone]. (1988)

Patients with hyperdynamic symptoms of a severe sepsis and patients after severe head injury show remarkable metabolic disturbances, which become apparent in a persistent catabolic stage. This was found in 17 septic patients (group I) and in 20 patients after severe head injury (group II), who were studied for a period of 10 days. During this time the urea production rate (UPR) and the catabolic index (CI) were measured. After a preliminary period of 5 days a stimulation test of hGH secretion using arginine was carried out to estimate the secretion of hGH, insulin and blood glucose. After this stimulation test a substitution therapy using 0.05 IU/kg B.W. i.m. hGH (Crescormon, Kabi Vitrum, München) was applied to 11 patients in group I (group Ia) and in 8 patients in group II (group IIa) who were then compared with patients without substitution therapy. The mean values of hGH basic secretion were the same in all groups and were within the normal range. 30 min after stimulation it was possible to identify a distinct response pattern; 90 min after stimulation there was no significant response. All groups showed significantly elevated levels of insulin; no further elevation after stimulation was observed. The blood glucose levels in all groups remained within the normal range at all times. All the groups were similar regarding behavior of the investigated parameters.(ABSTRACT TRUNCATED AT 250 WORDS)
Expression of epidermal growth factor receptor in urinary bladder cancer metastases (1998)

Bladder cancers frequently exhibit an increased number of epidermal growth factor receptors (EGFR) in comparison to normal urothelium. The EGFR could potentially be a target for toxic conjugates. The aim of our study was to compare the expression of EGFR in metastases with concurrent or primary tumour in the urinary bladder using immunohistochemical techniques and a monoclonal antibody. Tumour material from 20 patients was investigated. The majority (13/20) of the metastases were homogeneously stained and showed a moderate to strong membranous staining for EGFR. The expression of EGFR in primary bladder tumours and metastases was similar. There was no indication that tumour tissue exposed to chemotherapy or radiation had a decreased number of EGFR. Targeting of the EGFR thus seems potentially applicable to metastatic disease. Int. J. Cancer 76:189–193, 1998.© 1998 Wiley-Liss, Inc.
A Minor Acylated Triterpenoid Saponin from the Seeds of Pithecellobium dulce (1999)

A novel acylated triterpenoid saponin, designated pithecelloside, is isolated from the seeds of Pithecellobium dulce and characterised as 3-O-[α-L-arabinopyranosyl-(1 → 2)-α-L-arabinopyranosyl-(1 → 6)-β-D-glucopyranosyl]-21β-O-[(2′E)-6′-hydroxy-2′,6′-dimethylocta-2′,7′-dienoyl]acacic acid 1.
EXPERIMENTAL AND NUMERICAL STUDY OF THE MICRO-MECHANICAL FAILURE IN COMPOSITES (2013)

The interfacial parameters are characterized by comparing the experimental results with the FE analysis. Subsequently, the progressive interfacial damage evolution is studied.
A test for holomorphy in the unit ball of 𝐶ⁿ (1984)

A new test for holomorphy in the unit ball of <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="bold upper C Superscript n"> <mml:semantics> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msup> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="bold">C</mml:mi> </mml:mrow> </mml:mrow> <mml:mi>n</mml:mi> </mml:msup> </mml:mrow> <mml:annotation encoding="application/x-tex">{{\mathbf {C}}^n}</mml:annotation> </mml:semantics> </mml:math> </inline-formula> in the spirit of Morera’s theorem is given.
Iridium as a permanent modifier for determination of cadmium and lead in sediment and biological samples by furnace atomization plasma emission spectrometry (2002)

The use of iridium as a permanent modifier for the determination of lead and cadmium in marine sediment and biological tissues by furnace atomization plasma emission spectrometry (FAPES) was evaluated. The Ir coating procedure, atomization conditions and FAPES parameters were optimized for best analytical response and minimum background signal. Good precision (less than 3% RSD) can be achieved with the proposed method. Certified Reference Materials from the National Research Council of Canada were analyzed to verify the accuracy of this technique. Matrix interference was compensated for by the use of standard additions calibration and good agreement was achieved between found and certified values. Detection limits of 3.8 ng g−1 for Pb and 4.0 ng g−1 for Cd in MESS-3 and PACS-2 marine sediment and 4.1ng g−1 for Pb and 2.2 ng g−1 for Cd in DOLT-2 and TORT-2 biological tissues were obtained.
Amino acids and peptides. XXI. Synthesis of N-terminal heptapeptide of mammalian metallothionein(MT) and evaluation of its immunoreactivity. (1988)

The common N-terminal heptapeptide, Ac-Met-Asp-Pro-Asn-Cys-Ser-Cys-OH, Ac-(MT II 1-7)-OH, of mammalian metallothioneins (MTs) was synthesised by a conventional solution method using newly developed β-2-adamantylasparate. This peptide was as reactive as native MT with a monoclonal antibody produced against rat Zn-MT II.
ChemInform Abstract: Boom in the Development of Non‐Peptidic β‐Secretase (BACE1) Inhibitors for the Treatment of Alzheimer′s Disease (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fagopyritols, <scp>d</scp>-<i>chiro</i>-Inositol, and Other Soluble Carbohydrates in Buckwheat Seed Milling Fractions (2000)

Fagopyritols are mono-, di-, and trigalactosyl derivatives of D-chiro-inositol that accumulate in seeds of common buckwheat (Fagopyrum esculentum Moench) and may be important for seed maturation and as a dietary supplement. Fagopyritols and other soluble carbohydrates were assayed in mature groats and 11 milling fractions of common buckwheat seed. Because fagopyritols are in embryo and aleurone tissues, differences in fagopyritol concentrations reflect varying proportions of these tissues in each milling fraction. Bran milling fractions contained 6.4 g of total soluble carbohydrates per 100 g of dry weight, 55% of which was sucrose and 40% fagopyritols. Flour milling fractions had reduced fagopyritol concentration [0.7 g/100 g of dry weight total fagopyritols in the dark (Supreme) flour and 0.3 g/100 g in the light (Fancy) flours]. Fagopyritol B1 was 70% of total fagopyritols in all milling fractions. Fagopyritols were 40% of total soluble carbohydrates in groats of two cultivars of common buckwheat but 21% in groats of tartary buckwheat [Fagopyrum tataricum (L.) Gaertn.], probably a reflection of environment and genetics. A rhamnoglucoside present in tartary buckwheat was not detected in common buckwheat.
Methyltriacetylene (CH <sub>3</sub> C <sub>6</sub> H) toward TMC-1: The Largest Detected Symmetric Top (2006)

We report the detection of a new interstellar methylpolyyne, CH3C6H (methyltriacetylene), with the 100 m Green Bank Telescope. Ten spectral lines of this species were detected toward the Taurus molecular cloud (TMC-1): the K = 0 and K = 1 components of the 12,K-11,K, 13,K-12,K, 14,K-13,K, 15,K-14,K, and 16,K-15,K transitions. Also observed were the K = 0 and K = 1 components of the 6,K-5,K transition of CH3C4H (methyldiacetylene). For both methylpolyynes, no higher energy K-components were detected, which is consistent with the 10 K kinetic temperature of the TMC-1 dark cloud. Moreover, radio spectral line data of the cyanopolyyne, methylcyanopolyyne, and methylpolyyne carbon-chain sequences were studied, and strong correlations are found among the values of the three different carbon-chain slopes when total column densities of sequence members are plotted against the number of carbon atoms in the carbon chain. This result suggests that the formation chemistry for all these carbon-chain sequences is common, and the total column density of the next larger, undetected species in each of the three carbon chain sequences is predicted.
Power efficient CDMA broadcast system doing without any channel knowledge at the receivers, a nonobvious modification of THP (2005)

For CDMA broadcast transmission recently the linear receiver oriented scheme transmit zero forcing (TxZF) was proposed, in which the receiver algorithms are a priori determined, whereas the transmitter algorithms follow a posteriori. A main asset of this scheme is its low receiver complexity. In addition, it does without sacrificing downlink transmission resources to training signals for channel estimation, which is beneficial for capacity, and its combination with MlMO antenna structures is straightforward. A nonlinear modification of the scheme TxZF termed transmit nonlinear zero forcing (TxNZF) is presented with a view to reduce the required transmit power considerably, a feature mitigating intercell interference in cellular systems and, thereby, further enhancing capacity, and being also attractive with respect to the growing electro-phobia of the public. The crux of TxNZF consists in using multiply connected decision regions in the detectors of the receivers and in advantageously selecting the partial decision regions from the possible set of such regions depending on the messages to be transmitted. TxNZF is particularly effective in the case of relatively large attenuation differences of the channels between the transmitter and the individual receivers. The envisaged practical application of the scheme TxNZF are CDMA mobile radio downlinks. In such systems due to shadowing and to largely different distances between the base station and the mobile terminals, large attenuation differences prevail. The ideas presented in this paper are related to the well known concept of Tomlinson-Harashuna precoding (THP).
Explosive Reaction for Barium Niobium Perovskite Oxynitride (2017)

An intense exothermic and explosive reaction between Ba(OH)2, NbCl5, and NaNH2 produced barium niobium perovskite oxynitride in seconds. The addition of hexane reduced the risk of explosion during mixing of the starting materials, and subsequent heat treatment at 498 K in hexane allowed control of this exothermic reaction, leading to formation of the perovskite oxynitride with fewer impurities. The synthesis of barium tantalum perovskite oxynitride under similar reaction conditions was successful.
Sex pheromone of the rice leaffolder moth, Cnaphalocrocis medinalis (Lepidoptera: Crambidae): Synthetic Indian and Philippine blends are not attractive to male C. medinalis, but are attractive to C. pilosa in the South-Western islands in Japan. (2001)

Field bioassays with 3 different types of synthetic pheromone blends (Japanese, Indian and Philippine blends) based on geographic variation in the sex pheromones in Cnaphalocrocis medinalis were performed in 1998 and 1999 in the South-Western Islands of Japan. Only the Japanese blend attracted C. medinalis males, while neither the Indian nor the Philippine blend showed attractiveness, as in the Japan mainland. However, both the Philippine and the Indian blends attracted males of a different species, C. pilosa, which is closely related to C. medinalis. Geographic variation in the sex pheromones of C. medinalis as well as the relationship between C. medinalis and C. pilosa are discussed.
Possible neurologic effects of aspartame, a widely used food additive. (1987)

The artificial sweetener aspartame (L-aspartyl-L-phenylalanyl-methyl ester), is consumed, primarily in beverages, by a very large number of Americans, causing significant elevations in plasma and, probably, brain phenylalanine levels. Anecdotal reports suggest that some people suffer neurologic or behavioral reactions in association with aspartame consumption. Since phenylalanine can be neurotoxic and can affect the synthesis of inhibitory monoamine neurotransmitters, the phenylalanine in aspartame could conceiveably mediate neurologic effects. If mice are given aspartame in doses that elevate plasma phenylalanine levels more than those of tyrosine (which probably occurs after any aspartame dose in humans), the frequency of seizures following the administration of an epileptogenic drug, pentylenetetrazole, is enhanced. This effect is simulated by equimolar phenylalanine and blocked by concurrent administration of valine, which blocks phenylalanine's entry into the brain. Aspartame also potentiates the induction of seizures by inhaled fluorothyl or by electroconvulsive shock. Perhaps regulations concerning the sale of food additives should be modified to require the reporting of adverse reactions and the continuing conduct of mandated safety research.
Superconducting Properties and Surface Resistance of YBCO Strip Lines with Ag2O and Ag Addition. (1992)

Superconducting properties and surface resistance, Rs, of YBa2Cu3O7-y strip lines prepared by the screen printing were investigated. The Tc of these strip lines with and without Ag2O and Ag additions was almost the same. However, Jc values increased with increasing the addition of Ag and Ag2O. The Rs values of these strip lines in superconducting state decreased with increasing the addition of Ag and Ag2O, and the optimum addition was about 10-15wt.%. The lowest values of Rs were about 15mΩ at 60K. The Rs values were proportional to frequency f1, in contradiction to f2 dependence expected from the two-fluid model.
P2‐275: βCTF is an inefficient substrate for proteolysis by gamma‐secretase (2010)

gamma-Secretase hydrolyzes type I membrane proteins within the hydrophobic environment of the lipid bilayer. Over 50 molecules have been reported as gamma-secretase substrate, which indicates that inhibition of gamma-secretase activity to prevent Abeta production results in harmful side effects. However it remains unclear whether substrate specificity exists on gamma-secretase. Given that gamma-secretase possesses substrate specificity, it may lead to substrate specific gamma-secretase modulation. The aim of this study is to examine substrate specificity of gamma-secretase. We established a methodology to generate recombinant gamma-secretase substrates with bona fide N-terminal sequence. gamma-Secretase substrates, such as betaCTF, alphaCTF, S2-cleaved Notch and alpha-cleaved APLP2, were N-terminally fused with APP signal peptide followed by subtilisin-recognition sequence. After expressed in sf9 cells, those recombinant proteins were isolated by affinity purification with S189 subtilisin immobilized resin. Once captured by the resin, the recombinant proteins were precisely cleaved by addition of fluoride ion at the C-terminal of the subtilisin-recognition sequence, which generated gamma-secretase substrates carrying bona fide N-terminal sequence. The gamma-secretase substrates were incubated with CHAPSO-solubilized microsomal fraction of CHO cells that exhibited high specific activity (Kakuda et al., JBC 2006). We measured intracellular domain of the substrates cleaved by gamma-secretase by means of quantitative western blot. Apparent Km values for betaCTF, alphaCTF, S2-cleaved Notch and alpha-cleaved APLP2 were in a range of 790-820 nM, whereas apparent Vmax values were 1.85 nM/min for betaCTF and 8.11-9.06 nM/min for the other substrates. The Vmax/Km value for betaCTF was approximately one-fifth of that for the other substrate. We also examined kinetics of AICD production from alphaCTF in the presence of S2-cleaved Notch. Various concentrations of alphaCTF were incubated with gamma-secretase in the presence of defined amounts of S2-cleaved Notch. Double reciprocal plot of the AICD production in the presence of S2-cleaved Notch generally displayed a pattern characteristic of competitive inhibition. Among substrates tested, betaCTF is an inefficient substrate for proteolysis by gamma-secretase.