gebhart/patrepeval huggingface dataset:
Transarterial infusion chemotherapy with cisplatin plus S-1 for treating hepatocellular carcinoma: Results of a phase I trial. (2012)

357 Background: In Japan, transarterial infusion chemotherapy (TAI) with cisplatin (CDDP) is used for advanced hepatocellular carcinoma (HCC) patients (pts), and the response rate (RR) was 33.8% in previous phase (P) II study. S-1, oral systematic chemotherapy, is also promised for advanced HCC pts, and achieved 23.1% RR in previous P-II study. The clinical feasibility and efficacy of CDDP for TAI plus S-1 in pts with advanced HCC has not yet been investigated. Thus, we performed this trial to determine the recommended dose (RD). Methods: Although 13 Child–Pugh class A or B pts with advanced HCC entered themselves for this P-I trial, 1 pts of them was excluded from this trial due to the breach of criteria. The pts received TAI with CDDP (infusion on day 1 of the courses) plus S-1 (daily oral administration on days 1–21 of the courses), every 5 weeks until disease progression. The dose-escalation scheme is provided in the table below. Results: Three dose levels were used for the 12 pts. Dose-limiting toxicity was not observed in 3 pts at level 1, 3 pts at level 2, and 7 pts at level 3; therefore, the RDs for CDDP and S-1 were considered to be 65 mg/m 2 and 80–120 mg/day, respectively (level 3). Grade 3 adverse events were reported for 10 pts and were considered to be related to the study drugs for 6 pts: 2 pts, increased alanine aminotransferase level; 2 pts, increased aspartate aminotransferase level; 1 pt, anemia; and 1 pt, decreased platelet count. The total number of treatment courses was 25, with a mean of 1.5 courses per pt (range, 1–6 courses). The median progression-free survivaltime was 73 days. The disease control rate was 58% (7/12) ; 2 pts (16%) achieved partial response and 5 (42%) had stable disease. Conclusions: TAI with CDDP plus S-1 can be used safely with promising tumor control for treating advanced HCC. The RD to be used for a P-II study of this regimen was determined to be level 3. [Table: see text]
Development and analysis of a small-size electric field coupling wireless power system (2015)

This study intends to fabricate a small-size capacitive wireless transmission device. As to the design of electrode plates, the active electrode is designed in two ways, through row array and column array, and the area of an electrode plate is limited to below 20.25 cm 2 . Moreover, the passive electrode of row-array electrode plates is designed in three ways: general row array, window array, and rhombus array. As seen from the results of circuit simulation, the transmission efficiency of the capacitive wireless transmission device is as high as 0.7. In the actual circuit experiment, the electrode plate in the window-array design has the highest efficiency at 51%. In addition, the electrode plates in the window array and those in other arrays have higher stability and transmission efficiency. In the rotational angle dislocation experiment, the unit area current amount of the column-array electrode plates in the high coupling region is also smaller than that of the window-array electrode plates. However, the performance of column-array electrode plates reaches higher stability in the angle dislocation experiment, and its anti-angle dislocation is obviously higher than that of the electrode plates designed in the other three row arrays. Moreover, when the area of the column-array electrode plates is 22.25 cm 2 , the highest transmission distance is 22.5 mm.
IP Addresses in Email Clients. (2004)

IP addresses are an important tool for fighting spam, used for safe lists, blackhole lists, anti-spoofing and related purposes. While it is trivial to find the sender&apos;s IP address in most email server software, it turns out to be surprisingly di#cult to do so in email client software: we explain why. This implies that either alternative approaches are needed (typically signature-based) or that new standards for communicating between clients and servers are needed. We suggest several forms such standards might take.
Development of Miniature Marx Generator using BJT (2009)

We have developed a small sized all solid-state pulsed power generator for industrial applications and biomedical applications such as an ozonizer and a cell treatment. In this paper, a novel 19 stages Miniature Marx Generator using bipolar junction transistors (BJTs) to produce high voltage and low energy pulses with nano-seconds pulse rise time is described. This pulsed power generator is consisted of a Cockroft-Walton circuit and a Miniature Marx circuit. The Cockroft-Walton circuit charges all capacitors and the charging voltage is about 300 V. The Miniature Marx circuit is consisted of resistors, capacitors, and BJTs as extreme high speed closing switches using avalanche breakdown phenomena. Another set of BJTs are placed in parallel with the load to turning off a load current. The size of Miniature Marx circuit is 72 mm × 95 mm. The pulsed power generator developed here has an output voltage of about -5.2 kV and a pulse duration of 7 ns. The charging energy of primary capacitors is the milli-Joule regime.
Ion image sensors based on CCD/CMOS technology (2012)

128 × 128 proton ion image sensors were successfully fabricated by using the CCD/CMOS image sensor technique, and real time imaging of a chemical reaction and pH distribution was carried out. The ion concentration variations by a chemical reaction were observed by 17 msec step (i.e. 57 flames per sec). The image sensor was able to take pH distributions of hippocampus successfully. It means that the novel image sensor can be applied to a biomedical and biochemical field.
Management of Antithrombotic Therapy in Atrial Fibrillation Patients Presenting with Acute Coronary Syndrome and/or Undergoing Percutaneous Coronary Intervention/ Stenting (2009)

There remains uncertainty over optimal antithrombotic management strategy for patients with atrial fibrillation (AF) presenting with an acute coronary syndrome and/or undergoing percutaneous coronary intervention/stenting. Clinicians need to balance the risk of stroke and thromboembolism against the risk of recurrent cardiac ischaemia and/or stent thrombosis, and the risk of bleeding. This consensus document comprehensively reviews the published evidence and presents a consensus statement on a 'best practice' antithrombotic therapy guideline for the management of antithrombotic therapy in such AF patients.
ChemInform Abstract: SELBSTRK. VON DIAETHYLNITROXID‐RADIKALEN (1970)

Abstract Die Kinetik der Selbstreaktion des photolytisch aus dem Hydroxylamin (I) erzeugten Radikals (II) wird in einem weiten Temperaturbereich (‐135 bis 30°C) anhand des ESR‐Spektrums untersucht.
Award-Winning System Assays Radiation Waste With Radiation (2000)

More than half a million drums of radioactive waste are stored at 30 Department of Energy sites across the nation, with thousands more to come as facilities at weapons complex sites are dismantled. All of these drums must be assayed to determine and verify their contents and levels of radioactivity so they can be transported for permanent storage or disposal. A system that assays containers of radioactive waste safely, accurately, and nonintrusively has garnered a prestigious R and D 100 Award--presented annually by R and D Magazine to ''the 100 most technologically significant new products and processes of the year''--for Lawrence Livermore National Laboratory and its commercial partner, Bio-Imaging Research, Inc. (BIR) from Lincolnshire, Illinois. The award-winning Waste Inspection Tomography for Non-Destructive Assay (WIT-NDA) system was developed by a team of engineers and physicists headed by Livermore's Patrick Roberson and Harry Martz. The system combines active and passive computed tomography and nuclear spectroscopy to accurately quantify all detectable gamma rays emitted from waste containers. The WIT-NDA is part of BIR's Waste Inspection Tomography system, which provides nondestructive examination and assay of radioactive waste and has been commercially available since August 1999. ''The WIT-NDA is an excellent example of successful technology transfer between a DOE national laboratory and a small private business'', says Richard Bernardi, WIT program manager for BIR.
Colorimetric Sensors using Plasmonics Grating on a Metallic Mirror (2014)

We experimentally demonstrate a low-cost colorimetric sensor in which the change in surrounding refractive index is measured using simple image processing. This sensor consists of two-dimensional gold nanopatch grating on a highly reflective mirror.
CAN-Mediated Oxidations for the Synthesis of Xanthones and Related Products (2010)

Reaction of (2,4,5-trimethoxyphenyl)(2-hydroxyphenyl)methanone with ceric ammonium nitrate furnished the xanthone, 2,3-dimethoxy-9H-xanthen-9-one. Under the same conditions the related (1,4-dimethoxynaphthalen-2-yl)(2-hydroxyphenyl)methanone resulted in the formation of 12a-methoxy-5H-benzo[c]xanthenes 5,7(12aH)-dione. Other examples of this novel transformation are also outlined.
Discovery of an Orally Efficacious Imidazo[5,1-<i>f</i>][1,2,4]triazine Dual Inhibitor of IGF-1R and IR (2010)

This report describes the investigation of a series of 5,7-disubstituted imidazo[5,1-f][1,2,4]triazine inhibitors of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR). Structure-activity relationship exploration and optimization leading to the identification, characterization, and pharmacological activity of compound 9b, a potent, selective, well-tolerated, and orally bioavailable dual inhibitor of IGF-1R and IR with in vivo efficacy in tumor xenograft models, is discussed.
Precision and Accuracy of Identification of Anatomical Surface Landmarks by 30 Expert Hip Arthroscopists. (2017)

We conducted a study to assess 30 expert hip arthroscopists' ability to identify common surface landmarks used during hip arthroscopy. Thirty hip arthroscopists independently performed a blinded examination of an awake supine human volunteer for identification of 5 surface landmarks: anterior superior iliac spine (ASIS), tip of greater trochanter (GT), rectus origin (RO), superficial inguinal ring (SIR), and psoas tendon (PT). The examiners applied the labels ASIS, GT, RO, SIR, and PT to the landmarks. An ultrasonographer performed a musculoskeletal ultrasound examination and applied labels as well, and a photographer documented the examiner labels after obtaining overhead and lateral digital images with use of fixed camera mounts. Digital overlay composite images of arthroscopist and ultrasonographer labels were analyzed. Direction and distance of inaccurately placed labels were compared with known values for neurovascular structures previously reported for common arthroscopic portals. Average distance from examiner-applied labels to ultrasonographer-applied labels was 31 mm for ASIS, 24 mm for GT, 26 mm for RO, 19 mm for SIR, and 35 mm for PT. Interobserver variability of examiner-applied labels was recorded as areas of 95% predictive interval: 65 cm2 for ASIS, 16 cm2 for GT, 221 cm2 for RO, 38 cm2 for SIR, and 29 cm2 for PT. Examiner labels demonstrated the highest potential for injury because of anterior portal inaccuracy. Expert hip arthroscopists varied in their ability to accurately and precisely identify common surface landmarks about the hip, using only manual palpation.
Differences in proviral DNA load between HIV-1- and HIV-2-infected patients (2008)

Introduction: The lesser pathogenicity of HIV-2 relative to HIV-1 is generally attributed to its slower replication. To compare the amounts of total HIV DNA during human HIV-1 and HIV-2 infection, we developed a quantitative real-time PCR method with a unique external quantification standard based on a single plasmid harboring both the HIV-1 and the HIV-2 LTR. Methods: Viral DNA load was compared between 40 HIV-1-infected and 42 HIV-2-infected antiretroviral-naive patients. Results: The difference between HIV-1 and HIV-2 proviral DNA load was highly significant in patients with CD4 cell counts > 500 cells/μl [HIV-1: n = 14; median, 2.5; interquartile range (IQR), 2.1–2.7; HIV-2: n = 22, median, 1.6; IQR, 1.0–2.0] and in patients with CD4 cell counts between 300 cells/μl and 500 cells/μl (HIV-1: n = 12; median, 2.7; IQR, 2.3–2.8; HIV-2: n = 11; median, 2.0; IQR, 1.0–2.4). Too few HIV-2-infected patients had CD4 cell counts < 300 cells/μl to detect a significant difference but DNA values were again lower in HIV-2-infected patients (HIV-1: n = 14; median, 2.9; IQR, 2.2–3.2; HIV-2: n = 9; median, 2.7; IQR, 2.2–3.3). Conclusions: These differences are in line with the natural histories of the two infections and show that HIV-2 infection is a valid model for studying the pathophysiology of HIV infection in general.
ChemInform Abstract: Intramolecular Radical Additions to Quinolines. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Surface Shear Rheology of a Polymerizable Lipopolymer Monolayer (2002)

We have used an interfacial stress rheometer to study the changes in the mechanical shear properties of a Langmuir monolayer of a linear polymer with reactive side chains. The polymer investigated had a linear hydrophilic backbone consisting of poly(ethylene imine-co-ethyl oxazoline) and contained 20% hydrophobic sorbyl side chains, making it amphiphilic and capable of forming stable monolayers at the air−water interface. The sorbyl moiety in the side chain was photopolymerizable at 254 nm. Upon exposure of the film to UV light, the surface dynamic shear modulus, Gs‘, which is a measure of the elasticity, increased 1000-fold to ∼2 mN/m. This large increase in elasticity arises from the formation of a network by reaction of side chains on different polymer backbones. Rubber-like properties were deduced from the frequency dependence of the moduli and from creep experiments, where elastic recoil could be observed upon removing the applied stress. Such a network could be formed over a wide range of surface pressures ranging from 5 to 25 mN/m. We investigated the cross-linking kinetics upon UV exposure as a function of temperature, initial surface pressure, and light intensity. We have developed a lumped kinetic model that agrees with the transient behavior of the storage modulus, our measure of the density of cross-link points. The reaction was independent of temperature (over 10−30 °C) and exhibited a first-order dependence on light intensity. Since the reactive side groups must be in close enough proximity for the interpolymer side chain reaction to occur, a threshold side chain density is required to form junction points. After extensive UV exposure, the elasticity of the network degraded, and the rate of degradation was faster for films polymerized at lower initial surface pressures.
Conversion of hydroxamic acids to N,O-diacyl hydroxylamines (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConversion of hydroxamic acids to N,O-diacyl hydroxylaminesEdward E. Smissman, Norman A. Dahle, and Victor D. WarnerCite this: J. Org. Chem. 1971, 36, 17, 2565–2566Publication Date (Print):August 1, 1971Publication History Published online1 May 2002Published inissue 1 August 1971https://pubs.acs.org/doi/10.1021/jo00816a047https://doi.org/10.1021/jo00816a047research-articleACS PublicationsRequest reuse permissionsArticle Views71Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mechanistic consequences of curved Stern-Volmer plots. Photolysis of cyclobutanone (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanistic consequences of curved Stern-Volmer plots. Photolysis of cyclobutanoneRonald James. Campbell, Edward W. Schlag, and Bruce W. RistowCite this: J. Am. Chem. Soc. 1967, 89, 20, 5098–5102Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/ja00996a002https://doi.org/10.1021/ja00996a002research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Adsorbate Geometry Distinction in Arenethiols by Ion/Surface Reactive Collisions (1999)

Reactive scattering of low-energy ions from surfaces gives scattered product ions in which new bonds are formed with the adsorbate with a sensitivity to adsorbate geometry. Reactions of Cr•+ and C5H5N•+, as well as chemical sputtering induced by Xe•+, are used to distinguished two well-characterized monolayer systems, namely 1,4-benzenedimethanethiol (BDMT) adsorbed on Au(111) and Ag(111) thin films. While the reaction of Cr•+ with the Au monolayer produces an ion assigned as CrC7H5S+, this product is completely absent upon reaction with the Ag monolayer. Pyridine (C5H5N•+) projectiles abstract C1−C8 hydrocarbon groups in 50 eV collisions with the Au monolayer, while the Ag monolayer shows only C1−C4 abstraction with a significantly different intensity pattern. Chemical sputtering (Xe•+) mass spectra of the two surfaces are substantially different; complete fragmentation of the Ag adsorbate occurs, leading to C2−C4 ion ejection, while more of the molecular features are preserved in the spectrum recorded for the Au monolayer. The experimental facts are interpreted in terms of the geometry of the BDMT molecule that is monocoordinated on Au and dicoordinated on Ag. The experiments are extended to the 1,2- and 1,3-ring isomers of 1,4-BDMT, which have not been characterized by other forms of surface spectroscopy. Ion/surface reactive collisions are useful for characterizing chemisorbates, including their geometrical orientation.
Symptom Burden In Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) (2013)

Objective Symptom burden is the combined impact of symptoms from disease and treatment on daily functioning. Lack of symptom recognition may result in failure to address symptoms and maximize patient functioning. Patient-reported outcomes (PROs) can be endpoints in clinical trials to establish treatment benefits. The purpose of this study was to define the content domain for a PRO measure of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) symptom burden.

Materials and Methods This is Part 1 of a study to develop a PRO AML/MDS symptom-burden measure. Patients with AML and MDS described symptoms over their disease courses in single qualitative interviews. Content analysis was used to identify symptoms and define the content domain for a PRO measure. After the interview, patients rated the worst severity of 13 common cancer-related symptoms in the last 24 hours on the M. D. Anderson Symptom Inventory (MDASI) to provide context for analysis.

Results Thirty patients participated in an interview (see [Table 1][1]). Content analysis found a total of 39 symptoms, 14 reported by 20% or more patients, occurring over the disease course. Fatigue and distress (followed by pain) was the symptom reported most often. The mean number of symptoms reported by patients with AML (5.46; sd = 2.83) and by patients with MDS (7.33; sd=4.18) was not significantly different. Proportionately patients with MDS reported more fatigue, disturbed sleep, drowsiness, shortness of breath, headache, and sadness but less pain and numbness/tingling than AML patients. Both groups of patients described symptom interference with day-to-day activities. On the MDASI, fatigue (followed by distress and disturbed sleep) was the symptom reported most often in the last 24 hours. Fatigue had the highest mean severity rating (3.37, sd = 3.36, 0-10 scale) on the MDASI.

View this table:

Table 1 
Patient Characteristics



Conclusions Patients with AML and MDS experience numerous symptoms related to disease and treatment, with fatigue and distress being the most prominent throughout the disease course. Qualitatively, the symptom burden experienced by the two groups of patients is similar. These symptoms can cause significant interference with daily activities. Accurate assessment and management of symptoms is critical to ensure optimal treatment with the best quality of life. The content domain for a PRO symptom-burden measure of AML and MDS encompasses the severity and activity interference of common symptoms of AML and MDS and its treatment.

Disclosures: No relevant conflicts of interest to declare.

 [1]: #T1
Isolation and Identification of the Female Sex Pheromone of the Potato Tuberworm Moth,<i>Phthorimaea operculella</i>(Zeller) (1976)

The sex pheromone produced by adult females of the potato tuberworm moth was isolated from unmated female moths reared in the laboratory. The gas Chromatographic and mass spectrometric data suggested the pheromone to be a tridecatrienyl acetate. The isolated pheromone was subjected to partial hydrogenation with hydrazine and hydrogen peroxide and subsequent ozonolysis to produce a mixture of ω-acetoxy-alkanals. They were identified by mass Chromatographic technique as 4-acetoxy-butanal, 7-acetoxy-heptanal, and 10-acetoxy-decanal respectively. Consequently, the pheromone was identified as 4,7,10-tridecatrienyl acetate except the geometric configuration.
Enhanced Cooling for an Electric Starter-Generator for Aerospace Application (2014)

A practical and reliable cooling solution for a high power density, high speed synchronous permanent magnet machine (PMSM) for an aero engine starter generator system is proposed in this paper. Commercial software packages based on lumped parameters network method and Computational Fluid Dynamics (CFD) are employed to identify the optimal cooling configuration. Other existing cooling techniques are also investigated and their performance compared.