gebhart/patrepeval huggingface dataset:
Comparison of radiosensitizing effects of the mammalian target of rapamycin inhibitor CCI-779 to cisplatin in experimental models of head and neck squamous cell carcinoma (2009)

To determine if the mammalian target of rapamycin (mTOR) inhibitor CCI-779 can sensitize head and neck squamous cell carcinoma (HNSCC) to radiotherapy (XRT) and compare the radiosensitizing effects to cisplatin with its known considerable toxicity. Radiosensitizing effects of CCI-779 were assayed on HNSCC cell lines in vitro. CCI-779 (5 mg/kg), cisplatin (1 mg/kg), and XRT (2 Gy) alone and in combination were evaluated for antitumor activity in mice bearing FaDu and SCC40 xenografts. Effects of CCI-779 on radiation-induced activation of the Akt/mTOR pathway were analyzed. Although CCI-779 did not sensitize HNSCC cells to ionizing radiation in vitro, combination of CCI-779 and XRT significantly augmented the in vivo tumor growth-inhibitory effects of XRT and CCI-779 (P < 0.05). In addition, CCI-779 + XRT suppressed tumor growth more effectively than cisplatin + XRT (P < 0.05). CCI-779 + XRT significantly improved survival compared with XRT alone in both cisplatin-sensitive FaDu (P < 0.01) and cisplatin-resistant SCC40 (P < 0.05) xenograft mice. There were no additional benefits of adding cisplatin to CCI-779 + XRT. CCI-779 significantly attenuated irradiation-induced up-regulation of the mTOR pathway, increased apoptosis and displayed potent antiangiogenic activity in FaDu xenografts that was further enhanced by its combination with XRT (P < 0.05), which may explain the mechanism of its selective radiosensitizing effects in vivo and not in vitro. Antitumor activity of XRT was enhanced when combined with CCI-779 in HNSCC xenograft model. CCI-779 + XRT showed antitumor activity superior to conventional chemoradiotherapy with cisplatin. These results pave the way for clinical trials using molecular targeted therapy with CCI-779 in combination with XRT for HNSCC treatment.
FIFTH Project solutions demonstrating new satellite broadband communication system for high speed train (2005)

Currently, the mobile broadband access service, for a very large number of Internet users, is growing. At the same time, mobile telecommunication technology proposes new and challenging solutions to reach users everywhere. The FIFTH (fast Internet for fast train hosts) Project, co-founded by the European Commission in the 5/sup th/ Framework IST, proposes a new and challenging network solution to make Internet access available, through broadband GEO-satellites, to high speed train passengers. A new mobile satellite terminal technology has been studied and a prototype has been designed and developed for a practical implementation in suitable demonstrator scenarios. The paper describes the end-to-end GEO-satellite network designed and implemented in a demonstrator framework of the FIFTH Project and installed in a suitable railway coach to execute experiments on the Italian railway network.
Metalloproteinases and TIMP-1 in proliferative vitreoretinopathy. (1997)

Conference Article| May 01 1997 Metalloproteinases and TIMP-1 in proliferative vitreoretinopathy G Astrid Limb; G Astrid Limb 1Department of Immunology, St Thomas' Hospital, UMDS, London Search for other works by this author on: This Site PubMed Google Scholar Karen Miller; Karen Miller 2Neures Ltd, Abingdon, UK Search for other works by this author on: This Site PubMed Google Scholar Anthony H Chignell; Anthony H Chignell 1Department of Ophthalmology, St Thomas' Hospital, UMDS, London Search for other works by this author on: This Site PubMed Google Scholar Thomas H Williamson; Thomas H Williamson 1Department of Ophthalmology, St Thomas' Hospital, UMDS, London Search for other works by this author on: This Site PubMed Google Scholar Robert D Hollifield; Robert D Hollifield 1Department of Immunology, St Thomas' Hospital, UMDS, London Search for other works by this author on: This Site PubMed Google Scholar Dudley C. Dumonde Dudley C. Dumonde 1Department of Immunology, St Thomas' Hospital, UMDS, London Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1997) 25 (2): 234S. https://doi.org/10.1042/bst025234s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation G Astrid Limb, Karen Miller, Anthony H Chignell, Thomas H Williamson, Robert D Hollifield, Dudley C. Dumonde; Metalloproteinases and TIMP-1 in proliferative vitreoretinopathy. Biochem Soc Trans 1 May 1997; 25 (2): 234S. doi: https://doi.org/10.1042/bst025234s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search © 1997 Biochemical Society1997 Article PDF first page preview Close Modal You do not currently have access to this content.
Effect of chlorocamphene on the isoenzyme spectrum of lactate dehydrogenase in rat serum and liver. (1976)

Rats were used to study the general activity and the isoenzyme spectrum of lactate dehydrogenase (LDH) during single-instance and long-term introduction of polychlorocamphene. Total lactate dehydrogenase activity decreases in the liver during the single-instance introduction of half the LD50 (120 mg/kg). The isoenzyme spectrum of LDH is characterized by an increase in the quantity of LDH1, LDH2, and LDH3 and by a decrease in the amount of LDH4. The overall LDH activity does not change in blood serum. The isoform ratio changes insignificantly and LDH1 falls, but normalized 15 days after the introduction of the compound. Long-term introduction of polychlorocamphene at levels 1/100 the LD50 dose over 1.3 and 6 months causes a reduction in the overall LDH activity, both in the liver and in the serum. A decrease in the activity of the basic LDH isoenzyme of the liver (LDH5) and a sharp increase in LDH3 are characteristic for the isoenzyme spectrum of the liver. LDH1 and LDH4 decrease and LDH2 and LDH3 increase in blood serum. Beginning with the third month of polychlorocamphene introduction, LDH1 tends to return to normal levels. LDH2, LDH3, and LDH4 do return to normal levels, while LDH5 increases regularly. This results in a reduction of the number of H subunits and an increase of M subunits. This is characteristic of hypoxic states. On comparing the changes in the LDH enzymes of the liver and blood serum, it can be considered that the introduction of polychlorocamphene does not result in an increase in the permeability of the cellular membranes of the liver for LDH isoenzymes, while the observed isoenzyme spectrum shifts in blood serum are either the result of the biosynthesis of the isoforms of this enzyme changed by the compound or the result of the permeability for them of cells of other tissues.
Medicare in the 21st century. (2001)

The authors provide an overview of the Medicare program in terms of how the current program operates, the current issues it faces that may shape possible options for reform, and the implications of these features and issues for employment-based health plans. Current issues include adoption of a premium support model, changes in the eligibility age for Medicare benefits, Medigap insurance, benefits covered and customer service.
Utilisation du lupin blanc doux pour l'alimentation des ruminants : résultats et perspectives (1991)

— Parmi les 4 espces de lupin cultives dans le monde, Lupinus albus apparat comme la plus intressante en raison des teneurs en huile et en protines et des potentialits de rendement dans les conditions pdoclimatiques de l'Europe de fOuest. Les graines douces peuvent tre utili- ses comme matire premire dans l'industrie de l'alimentation du btail mais galement tre valori- ses directement pour nourrir les ruminants dans les exploitations d'levage. Elles doivent tre pralablement broyes avant distribution des vaches laitires haut niveau de production, mais peuvent tre consommes en l'tat par des taurillons en engraissement. La forte solubilit des ma- tires azotes (80%) justifie d'en raisonner le rationnement pour des ruminants sur la base du sys- tme des protines digestibles dans l'intestin (PDI). Les essais mens sur vaches laitires (3 essais) montrent ainsi que le lupin peut s'utiliser comme concentr de production en remplacement d'un m- lange crale-tourteau de soja aprs correction de la ration de base. Il peut aussi tre distribu comme concentr correcteur et de production s'il est associ des protines de qualit ou lui-mme amlior par voie technologique (extrusion par exemple). Dans ces conditions, on constate des performances laitires comparables avec nanmoins une tendance, non significative, l'amlioration des taux butyreux et la dtrioration des taux protiques. Par ailleurs, l'apport de grains entiers a permis d'engraisser et de finir des taurillons lourds avec des croissances au moins aussi bonnes que celles classiquement ralises avec un concentr soja-crales, et ce pour des consommations quivalentes de fourrages grossiers. Les efforts de slection devront donc essentiellement porter sur l'amlioration du rendement. Cependant, une valuation de la variabilit gntique disponible pour la solubilit des matires azotes serait ncessaire pour envisager une amlioration de ce ca- ractre.
Tissue and subcellular distribution of endonexin, a calcium-dependent phospholipid-binding protein (1990)

Conference Article| December 01 1990 Tissue and subcellular distribution of endonexin, a calcium-dependent phospholipid-binding protein JOHN H. WALKER; JOHN H. WALKER *Department of Biochemistry, University of Leeds, Leeds LS2 9JT, U.K. Search for other works by this author on: This Site PubMed Google Scholar CATHERINE M. BOUSTEAD; CATHERINE M. BOUSTEAD *Department of Biochemistry, University of Leeds, Leeds LS2 9JT, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROBYN BROWN; ROBYN BROWN †Department of Anatomy, University of Leeds, Leeds LS2 9JT, U.K. Search for other works by this author on: This Site PubMed Google Scholar JOANNA J. KOSTER; JOANNA J. KOSTER *Department of Biochemistry, University of Leeds, Leeds LS2 9JT, U.K. Search for other works by this author on: This Site PubMed Google Scholar C. ADAM MIDDLETON C. ADAM MIDDLETON †Department of Anatomy, University of Leeds, Leeds LS2 9JT, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1990) 18 (6): 1235–1236. https://doi.org/10.1042/bst0181235 Article history Received: June 12 1990 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation JOHN H. WALKER, CATHERINE M. BOUSTEAD, ROBYN BROWN, JOANNA J. KOSTER, C. ADAM MIDDLETON; Tissue and subcellular distribution of endonexin, a calcium-dependent phospholipid-binding protein. Biochem Soc Trans 1 December 1990; 18 (6): 1235–1236. doi: https://doi.org/10.1042/bst0181235 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Reaktionen halogenierter Acetaldehyde mit Schwefeltetrafluorid und Dialkylaminoschwefeltrifluoriden (1979)

Abstract Aldehyde 9 werden von Schwefeltetrafluorid und Dialkylaminoschwefeltrifluoriden 14 in geminale Difluoralkane 10 übergeführt. Davon abweichend bilden sich bei Reaktionen von SF 4 mit perhalogenierten Acetaldehyden als Nebenprodukte sowohl symmetrische als auch unsymmetrische diastereomere Difluorpolyhalogendiethylether 13 bzw. 12 . In Abhängigkeit vom Substitutionsgrad der Acetaldehyde können Difluoralkane im Produkt der Umsetzung mit Dialkylaminoschwefeltrifluoriden fehlen und diastereomere Bis(1‐fluor‐2‐polyhalogenethyl)ether 13 in guten Ausbeuten erhalten werden. Es werden Untersuchungen über den Einfluß von Reaktionsparametern auf die Ausbeuten und das Verhältnis der diastereomeren Komponenten zueinander beschrieben.
Interpreting Measured Serial Correlation In Univariate Time Series Analysis, With An Example From The New York Stock Exchange (1991)

This paper draws attention to the divergence of the observed serial correlations, for a typical given time series, from the corresponding theoretical autocorrelation pattern of the underlying generating process, which is not just a matter of sampling variation, and which seems to be commonly overlooked when analysing data infinance. We illustrate our thesis with examples from a case-study in the recent literature, where stock market transactions data for two distinct periods were analysed, and the behaviour of returns and various trading characteristics examined.
Dynamic Bargaining for Relay-Based Cooperative Spectrum Sharing (2012)

Cooperative spectrum sharing can effectively improve the spectrum usage by allowing secondary users (SUs) to dynamically and opportunistically share the licensed bands with primary users (PUs). In return, an SU will relay a PU's traffic to improve the PU's effective data rate. In this paper, we study how one PU and one SU achieve an efficient spectrum sharing through dynamic noncooperative bargaining. The key challenge is that the PU does not have complete information of the SU's energy cost. We model the dynamic bargaining with incomplete information as a dynamic Bayesian game, and investigate the equilibria under both single-slot and multi-slot bargaining models. Theoretical analysis and numerical results indicate that our proposed scheme can lead to a win-win situation, where both the PU and the SU obtain data rate improvements via the bargaining-based CSS mechanism. Furthermore, the SU can take advantage of the incomplete information to improve its bargaining power (also called reputation effect), and thus gain a higher data rate.
Microwave approach to highly irregular fiber optics (1998)

Introduction to Modal Theory of Optical Fiber. Low Birefringent Spun Fiber. Linearly Birefringent Fiber. Twist--Induced Circular Birefringence in Fiber. Practical Circular--Polarization Maintaining Optical Fiber. Elliptically Birefringent Fiber Transmission Characteristics. Fiber--Optic Analogs of Bulk--Optic Wave Plates. Postscript. Appendices. List of Symbols. Index.
Integrated imagery management system (2002)

The assessment of structural deterioration, as relates to the integrity of a structure, is presently limited by the use of analytical techniques. These are highly prone to interpretation of the transmitted imagery, which is the basis of all technical decisions. The technique must lend itself equally well to subsea use. These are the elements that oriented research toward the development of a technique permitting far more accurate assessments of structures as opposed to previous optical techniques. The Integrated Imagery Management System (IIMS) is a technique for measuring, controlling and managing due to its capacities to characterize surfaces and dimensions in a rapid and precise way via digital processing of photogrammetric images and by also permitting an actual view of structures and their components.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Effects of High Protein Diets on Thermogenesis, Satiety and Weight Loss: A Critical Review (2004)

For years, proponents of some fad diets have claimed that higher amounts of protein facilitate weight loss. Only in recent years have studies begun to examine the effects of high protein diets on energy expenditure, subsequent energy intake and weight loss as compared to lower protein diets. In this study, we conducted a systematic review of randomized investigations on the effects of high protein diets on dietary thermogenesis, satiety, body weight and fat loss. There is convincing evidence that a higher protein intake increases thermogenesis and satiety compared to diets of lower protein content. The weight of evidence also suggests that high protein meals lead to a reduced subsequent energy intake. Some evidence suggests that diets higher in protein result in an increased weight loss and fat loss as compared to diets lower in protein, but findings have not been consistent. In dietary practice, it may be beneficial to partially replace refined carbohydrate with protein sources that are low in saturated fat. Although recent evidence supports potential benefit, rigorous longer-term studies are needed to investigate the effects of high protein diets on weight loss and weight maintenance.
5′-Tailed Sequencing Primers Improve Sequencing Quality of PCR Products (2007)

Udgivelsesdato: 2007-Feb
Evaluation of alternative materials for condensing heat exchangers. Final report, August 1989-August 1990 (1990)

Ten different materials have been evaluated for their corrosion performance in a heat exchanger simulator that reproduces the environment encountered in a gas fired condensing furnace. These materials were a sol-gel enamel, thermally sprayed coatings of Alloys 314 and C-276, three thermally conducting polymer cements, two polyphenylene sulfide (PPS) coatings, a fluoropolymer/graphite fiber composite, and an impervious graphite. After the two-month test, only the PPS coatings and the impervious graphite survived, and the other materials failed either due to physical or chemical degradation. The impervious graphite exhibited unacceptable corrosion rates of up to 3 mpy, whereas the PPS coatings experienced some hardening. However, a properly applied PPS coating, on either aluminum or a carbon steel substrate, is considered to be a promising substitute for expensive super stainless steels that are presently used for the heat transfer surfaces in the secondary heat exchanger of condensing furnaces. It is recommended that the PPS coatings be more completely evaluated over extended periods using typical condensing furnaces.
<i>Prx1</i>and<i>Prx2</i>are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis (2001)

The aristaless-related homeobox genes Prx1 and Prx2 are required for correct skeletogenesis in many structures. Mice that lack both Prx1 and Prx2 functions display reduction or absence of skeletal elements in the skull, face, limbs and vertebral column. A striking phenotype is found in the lower jaw, which shows loss of midline structures, and the presence of a single, medially located incisor. We investigated development of the mandibular arch of Prx1(-/-)Prx2(-/-) mutants to obtain insight into the molecular basis of the lower jaw abnormalities. We observed in mutant embryos a local decrease in proliferation of mandibular arch mesenchyme in a medial area. Interestingly, in the oral epithelium adjacent to this mesenchyme, sonic hedgehog (Shh) expression was strongly reduced, indicative of a function for Prx genes in indirect regulation of SHH: Wild-type embryos that were exposed to the hedgehog-pathway inhibitor, jervine, partially phenocopied the lower jaw defects of Prx1(-/-)Prx2(-/-) mutants. In addition, this treatment led to loss of the mandibular incisors. We present a model that describes how loss of Shh expression in Prx1(-/-)Prx2(-/-) mutants leads to abnormal morphogenesis of the mandibular arch.
Monopulse printed circuit dipole array (1985)

The design and performance of a monopulse Ku-band planar array is described. The antenna is designed to provide 20 dB sidelobes sum pattern in the azimuth plane and an operating bandwidth of 1 GHz (16.25-17.25 GHz). The voltage standing-wave ratio (VSWR) of this array at the input is less than 2:1 over the bandwidth.
Deformation-induced structural developments of ultra-high molecular weight polyethylene (1989)

5.3 Results & Discussion 5.3.I Melting behaviour 5.3.2Relaxation and reversibility 5.4 Concluding remarks 5.
An Alkynyliodide Cycloaddition Strategy for the Construction of Iodoisoxazoles (2010)

The thermally promoted cycloaddition between alkynyliodides and nitrile oxides is reported. The process offers excellent regioselectivity and a broad scope with respect to both the iodoalkynes and chloro-oximes. Further functionalization of the highly decorated iodoisoxazole motifs can be achieved via Suzuki cross-coupling.
Novel light emissive yttrium-based nanoparticles and composites (2014)

Yttrium-based inorganic optical materials generally are of practical interest for three applications: solid state lighting/displays, lasers, and scintillators. Solid-state lighting is particularly desirable commercially for its efficiency and lifetime compared to traditional incandescent alternatives. This type of lighting technology is of increasing interest as incandescent light bulbs are being gradually phased-out due to government regulations on maximum wattage of these devices. Additionally, shortcomings in the current state of the art have driven the need for a more thermally stable material for use in this area. In this dissertation, we develop and characterize a novel composite material consisting of optically active yttrium-based nanoparticles doped into silica sol-gels. For lighting and display applications, low-cost, low-temperature synthesis methods for materials that meet or exceed the quality of the materials currently on the market are highly desirable. During the course of this work, we discuss the characterization of yttrium-based nanoparticles with respect to their incorporation in a sol-gel matrix composite. We then prepared these composite materials using a variety of methods and assess their quality according to a set of selection criteria and for lighting/display applications. Novel light-emitting composites consisting of Ce:YAG or Eu:Y2O3 (yttria) nanoparticles in an inorganic medium were successfully developed and characterized. The optical properties of the nanoparticles were maintained when incorporated into the sol-gel medium and were shown to be comparable with the current state of the art. Comparison was made between the nanoparticle emission and the composite emission and, in the case of the Ce:YAG, the CIE coordinates, showing no change between the emission intensities or peak locations. We successfully demonstrated the conversion of fluoride-based particles into Y2O3 during sol-gel processing and demonstrated that no reaction took place between the nanoparticles and the sol-gel medium. Stability of nanoparticles in suspension was overcome through the control of pH during sol-gel synthesis. Through both base- and/or acid-catalysis, we produced optically active nanoparticle doped sol-gel composites containing YAG and Yttria. Our results indicated no detrimental effect on the nanoparticles upon incorporation into the sol-gel matrix; this was demonstrated through XRD, where no silicate phases were observed, through EDX, where we saw no diffusion of yttrium into the sol-gel and no silicon diffusing into the nanoparticles, and through photoluminescence, where emissions were consistent with that of the as-made nanoparticles. These results led us to theorize that the nanoparticles, rather than being bonded to the matrix, are seated in the void space that is prevalent in sol-gel systems. Additionally, these materials are stable at much higher temperatures than current resin-based systems.