gebhart/patrepeval huggingface dataset:
Dynamics of propranolol dosing schedules (1983)

Kinetic and dynamic data from 27 healthy male subjects were evaluated in a double-blind, randomized, double-crossover study to test the hypothesis that 180 mg/day propranolol twice and three times a day would provide much the same plasma levels and beta 1-blockade. The data indicate that propranolol twice rather than three times a day should be favored when beta 1-blockade is needed in therapy. The dynamic efficacy of the two schedules was the same and maximum concentration, AUC0-24, and 0-hr plasma propranolol values were higher after twice-than after three-times-daily dosing. The degree of beta 1-blockade (reduction in exercise tachycardia) was much the same on both dosing regimens at trough concentrations. These data indicate that both twice- and three-times-a-day dosing schedules provide well-sustained 24-hr beta-blockade and are probably interchangeable for therapeutic purposes.
Psychoneuroimmunology and Immune System Link for Stress, Depression, Health Behaviors, and Breast Cancer (1998)

This article reviews the literature on psychoneuroimmunology and its theoretical underpinnings. It also reviews research related to the immune-system-link of stress, chronic stress, depression and health behaviors to breast cancer. Although the relationship between psychological characteristics and the immune system have been documented repeatedly, the significance of these effects has not been demonstrated in many studies empirically. The question whether the use of alternative therapies contributes to decreasing the progression of the diseased is often asked. Research in the area of psychoneuroimmunology can provide the answer to this question.
Vital Sign Ranges in Premature Neonates Using High Resolution Physiologic Data (2018)

Background: Heart rate (HR) and blood pressure are routinely measured in premature neonates. Although there are published vital sign norms for healthy term neonates, the current reference ranges used for critically ill premature neonates are not evidenced-based. The objective of this study is to determine new heart rate and blood pressure norms using high resolution physiologic data from a large cohort of premature neonates. Methods: We identified all …
Application of complex biocatalysts based on recombinant Penicillium verruculosum enzyme preparations in the hydrolysis of semichemical hardwood pulp (2014)

A comparative study of the efficiency of the biocatalysts based on recombinant enzyme preparations obtained from the Penicillium verruculosum fungus in the hydrolysis of semichemical hardwood pulp is performed. The activity of the biocatalysts with respect to different types of semichemical pulp and the dependence of the depth of exhaustive hydrolysis on its beating and drying is determined. It is shown that semichemical pulp after cooking with green liquor displays high reactivity in enzymatic hydrolysis with cellulase complex and is of clear interest as a substrate for scaling the bioengineering processes of renewable plant feedstock conversion.
American Society for Materials (ASM) International, Annual Meeting (November 5-8, 2001) (2002)

(2002). American Society for Materials (ASM) International, Annual Meeting (November 5-8, 2001) Materials Technology: Vol. 17, No. 1, pp. 38-41.
The novel N‐Methyl‐D‐Aspartate (NMDA) antagonist CGS 19755 prevents ischemia‐induced reductions of adenosine A<sub>1</sub>, NMDA, and PCP receptors in gerbil brain (1988)

Transient brain ischemia results in a selective destruction of cell bodies within the hippocampus and cortex. This cellular destruction appears to be mediated through a release of endogenous exictatory amino acids following the ischemic episode, since the neurotoxic effects of ischemia can be attenuated by compounds that have antagonist activity at N-methyl-D-aspartate (NMDA) receptors. In the present study, the protective effects of a novel NMDA receptor antagonist, CGS 19755, were further evaluated by using quantitative autoradiography to characterize adenosine A1, NMDA, PCP, and benzodiazepine receptors in ischemic gerbil brain. Bilateral carotid artery occlusion (20 minutes) resulted in marked decreases (30-60%) in adenosine A1, NMDA, and PCP, but not benzodiazepine, receptors in gerbil forebrain. Postischemic treatment with CGS 19755 was found to completely block the ischemia-induced decreases in brain adenosine and NMDA receptors. [3H]TCP binding in ischemic gerbil brain was also elevated by CGS 19755 treatment; significant differences remained, however, between the CGS 19755-treated and control gerbils. These results indicate that transient brain ischemia produces significant and selective alterations in gerbil forebrain receptor systems. The observed decreases in radioligand binding are probably reflective of an ischemia-induced destruction of forebrain structures. However, there is some evidence that transient ischemia can also cause long-term changes in the affinity of some receptor systems. The postischemic efficacy of CGS 19755 appears to be due to its ability to block the neurotoxic effects of transient ischemia.
Regulation of Glucosylation of Teichoic Acid (1974)

Abstract A procedure is described for the purification of phosphoglucomutase from Bacillus subtilis. Two species of the enzyme were separated by DEAE-cellulose chromatography. Phosphoglucomutase I contained 60 % of the total recoverable activity and phosphoglucomutase II accounted for the remaining 40 %. Examination of phosphoglucomutase I and II by acrylamide gel concentration suggested that each species was a dimer composed of active monomers. The physiological significance of two forms of phosphoglucomutase was indicated by the apparent shift in the concentration of monomeric and dimeric forms during growth as observed on histograms of acrylamide gels. Enzyme activities of phosphoglucomutase I and II were both enhanced by EDTA, ethylene glycol bis(β-aminoethylether)-N,N'-tetraacetic acid (EGTA), cysteine, and histidine. Preincubation was required with EDTA or EGTA for maximal activation; stimulation by histidine or cysteine, however, did not necessitate a preincubation period. The attendant paper describes several properties attributed to the regulation of this enzyme in B. subtilis.
Acoustic Bessel beam with combined optical trapping (2012)

Whilst the main strength of optical trapping techniques is arguably its precision and dexterity, the complimentary technique of acoustic trapping offers massive scalability and potentially larger forces. Acoustic traps commonly use ultrasonic standing waves to trap particles within the nodes of a pressure field, often over distances upwards of a few cm. Here, an acoustic Bessel beam has been created using a piezoelectric cylinder whereby particles are trapped within the entire 14 mm-diameter of the transducer (1.5 cm<sup>2</sup> trapping area). In optics, Bessel beams have the ability to trap particles over axial distances of several hundred microns. In this acoustic case, the Bessel function shape of the field is formed within the entire length of the cylinder (10 mm). Polymer spheres ranging from 1 μm to 100 μm in diameter are trapped simultaneously within the nodes of the standing wave field, in this case the concentric rings of a Bessel beam. The smaller particles within this field (< 5m) have also been trapped optically using a single beam optical tweezer, as the acoustic force scales such that it becomes comparable to that of the optical trap. This allows for a large range of particle sizes to be simultaneously trapped in a single device, and for large arrays (hundreds of mm<sup>2</sup>) to be formed acoustically within which particles can be individually optically trapped. This result demonstrates the complementarity of optical and acoustic trapping which makes it possible to trap large area arrays of particles whilst retaining the dexterity to manipulate individual particles.
The significance of serum levels of insulin‐like growth factor‐1 in patients with prostate cancer (2000)

There was no significant association between IGF-1 serum levels and prostate cancer. Short-term androgen withdrawal using LHRH analogues combined with anti-androgens had no effect on the levels of IGF-1.
Understanding Dermatan Sulfate−Heparin Cofactor II Interaction through Virtual Library Screening (2010)

Dermatan sulfate, an important member of the glycosaminoglycan family, interacts with heparin cofactor II, a member of the serpin family of proteins, to modulate antithrombotic response. Yet, the nature of this interaction remains poorly understood at a molecular level. We report the genetic algorithm-based combinatorial virtual library screening study of a natural, high-affinity dermatan sulfate hexasaccharide with heparin cofactor II. Of the 192 topologies possible for the hexasaccharide, only 16 satisfied the "high-specificity" criteria used in computational study. Of these, 13 topologies were predicted to bind in the heparin-binding site of heparin cofactor II at a ∼60° angle to helix D, a novel binding mode. This new binding geometry satisfies all known solution and mutagenesis data and supports thrombin ternary complexation through a template mechanism. The study is expected to facilitate the design of allosteric agonists of heparin cofactor II as antithrombotic agents.
Spontaneous production of anti‐mouse red blood cell autoantibodies is independent of the polyclonal activation in NZB mice (1990)

New Zealand Black (NZB) mice spontaneously develop an autoimmune hemolytic anemia together with a markedly increased production of polyclonal antibodies. The spontaneous generation of anti-mouse red blood cells (MRBC), anti-bromelain-treated MRBC (BrMRBC) and anti-DNA autoantibodies was compared to the polyclonal antibody formation in irradiated (800 rad) 2-month-old NZB mice reconstituted with bone marrow cells (BMC) from 2- or 10-month-old NZB mice. The injection of 10-month-old NZB BMC markedly accelerated the mortality rate in parallel with the progressive increase of anti-MRBC and anti-BrMRBC autoantibody production, but the spontaneous production of polyclonal IgM antibodies and anti-DNA autoantibodies was completely abolished down to the levels of non-autoimmune mice. In contrast, mice reconstituted with 2-month-old NZB BMC exhibited neither the acceleration of anemia nor the lack of polyclonal antibody production. These results strongly suggest that the spontaneous production of anti-MRBC autoantibodies, including anti-BrMRBC autoantibodies, in the NZB mouse occurs independently of the polyclonal B cell activation, and that they result from a specific immune stimulation, while the anti-DNA autoantibody production is a consequence of polyclonal antibody formation.
Determination of atrazine and carbaryl pesticide residues in vegetable samples using a multianalyte dipstick immunoassay format (2003)

A dipstick assay for the simultaneous determination of atrazine and carbaryl in vegetable samples was developed. The analytical method involved a fast extraction procedure followed by a multi-strip membrane test. The assay took 10 min, with a detection limit (naked eye) of 10 and 200 micro g l(-1) for atrazine and carbaryl, respectively. The cross-reactivities to related compounds tested were negligible except for propazine. Quantification of the pesticides was carried out by measuring the dot colour with a spectrophotometer. IC(50) values (inhibition constant at 50% of the maximum binding) of 2.04 microg l(-1) for atrazine and 92.8 microg l(-1) for carbaryl were achieved by this approach. Vegetable samples were extracted with MeOH. The proposed methodology was used to analyse atrazine and carbaryl and check for compliance with European Union maximum residue levels for vegetables. Recoveries (75-105%) were in agreement with those obtained by GC/MS or HPLC. Standard curves using 25% methanol/75% TBS were used for food sample assays using a multi-analyte dipstick. IC(50) values were 9.2 microg kg(-1) for atrazine and 179.2 microg kg(-1) for cabaryl.
Applications of Rotation Locular Countercurrent Chromatography in Natural Products Isolation (1984)

Abstract Purification of natural products and the fractionation of crude plant extracts are processes which traditionally involve adsorption and/or molecular exclusion chromatography. While countercurrent chromatography avoids the irreversible adsorption and decomposition frequently encountered in adsorption chromatography, the classical countercurrent distribution technique is both time- and solvent-consuming, consequently it is of limited value today. Rotation locular countercurrent chromatography (RLCC) is one of three new countercurrent techniques, the others being droplet contercurrent chromatography (DCCC)1 and planet coil countercurrent chromatography (PCCCC)2, which have revived the chromatographic application of liquid-liquid partition. We have employed a commercially available RLCC apparatus in the isolation of several natural products with a broad range of polarity demonstrating the versatility of the RLCC with regard to the functionality of the compounds to be isolated.
A simulated oral hygiene model to determine the efficacy of repeated exposure of amine oxide on the viability of <i>Streptococcus mutans</i> biofilms (2007)

The use of biocide in oral care products is important for controlling microbial pathogens. However, the use of biofilm tests that investigate repeated exposure to biocide, to mimic in situ treatment, has rarely been reported in the literature. The present study describes the application of a biofilm-based efficacy protocol, for testing the effect of repeated exposure to antimicrobials on biofilm, in an attempt to mimic oral care regimens. The activity of different treatment regimens, including repeated exposure to amine oxide (AO; C(10)-C(16)-alkyldimethyl N-oxides; 1.1% v/v), was conducted against 16-h Streptococcus mutans biofilms grown on hydroxyapatite disks. Single exposure to AO alone produced a 3 log(10) reduction in microbial count, but when combined with mechanical removal, a 5 log(10) reduction in microbial count was observed. Treatments incorporating repeated exposure to AO reduced the microbial count below the level of detection, even when exposure to AO was interspersed with recovery periods. The presence of organic load produced an additional 2 log(10) reduction in the microbial count. This study showed that the application of a biofilm-based efficacy protocol to mimic oral care regimens allowed the reproducible testing of repeated antimicrobial exposures against bacterial biofilm. In addition, AO was confirmed to be an excellent biocide for eliminating S. mutans biofilms and could therefore be beneficial in oral care formulations.
Improved cognitive-cerebral function in older adults with chromium supplementation (2010)

Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer's disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer's disease. Chromium (Cr) supplementation improves glucose disposal in patients with insulin resistance and diabetes. We sought to assess whether supplementation with Cr might improve memory and neural function in older adults with cognitive decline. In a placebo-controlled, double-blind trial, we randomly assigned 26 older adults to receive either chromium picolinate (CrPic) or placebo for 12 weeks. Memory and depression were assessed prior to treatment initiation and during the final week of treatment. We also performed functional magnetic resonance imaging (fMRI) scans on a subset of subjects. Although learning rate and retention were not enhanced by CrPic supplementation, we observed reduced semantic interference on learning, recall, and recognition memory tasks. In addition, fMRI indicated comparatively increased activation for the CrPic subjects in right thalamic, right temporal, right posterior parietal, and bifrontal regions. These findings suggest that supplementation with CrPic can enhance cognitive inhibitory control and cerebral function in older adults at risk for neurodegeneration.
Data-driven modeling of arterial wave propagation using non-invasive arterial pulse waveforms (2015)

This study investigates the validity of two non-invasive arterial pulse waveforms as viable indirect surrogates of arterial blood pressure waveforms, by conducting a data-driven modeling analysis of arterial wave propagation. Using the so-called “tube-load” model, we examined how well the relation between carotid versus femoral tonometry waveforms as well as carotid tonometry versus ankle pulse volume recording waveforms can be fitted to the model. Since the tube-load model describes the relationship between proximal versus distal blood pressures, we hypothesized that viable surrogates of blood pressure waveforms must be fitted well by the tube-load model. Preliminary results derived from 4 subjects with cardiovascular diseases indicated that carotid and femoral tonometry waveforms may serve as viable surrogate of arterial BP waveforms while PVR may need additional treatment, which was attributed to the nature of PVR waveforms: they are volume waveforms but not pressure waveforms.
Using Tablet-Type Ultrasonography to Assess Peripheral Veins for Intravenous Catheterization: A Pilot Study (2019)

Abstract Purpose: In clinical settings, ultrasonography (US) has recently been used to aid in the insertion of peripheral intravenous catheters (PIVCs). This cross-sectional study aimed to verify the reliability and validity of a tablet-type device in assessing vein size and depth for catheter site selection and detecting thrombus with resultant subcutaneous edema as a cause of catheter failure using US. Methods: Adult patients receiving infusions via a PIVC at a university hospital between January and February 2017 were included. All participants underwent US at the PIVC site. An expert sonographer and a nurse blinded to all information, except for ultrasonograms, evaluated the data. Intraclass correlation with 95% confidence interval (CI) was used to evaluate interrater and intrarater reliability of US assessment. To assess criterion-related validity, a high-end US notebook device was used for reference data collection. Pearson's correlation coefficient was used to evaluate criterion-related validity. Results: We observed 21 patients with 26 catheters. Intraclass correlations (95% CI) for the measured vein diameters and depths were as follows: intrarater reliability, 0.92 (0.57–0.98) and 0.78 (0.10–0.95); interrater reliability, 0.95 (0.78–0.99) and 0.94 (0.77–0.99); and Pearson's correlation coefficient for criterion-related validity, 0.74 ( P = 0.02) and 0.77 ( P = 0.02), respectively. However, the analysis of causes of catheter failure did not show reliable validity. Conclusion: This pilot study suggests that the tablet-type device is useful for assessing peripheral veins in clinical settings.
Deposition and Patterning of Polymeric Capsule Layers (2003)

Nanoengineered polymeric capsules of different types were deposited on solid supports by the solution casting technique. Patterning of these layers was performed with an electron beam. Electron beam irradiation of such layers resulted in the significant increase of the capsule adhesion to the substrate. Development of the patterns was carried out in detergent solutions under sonication. Capsules in the nonirradiated areas of the samples were washed out, while those in irradiated zones remained on the substrate surface. The possibility of two-step lithography on successively deposited layers of capsules of different types was demonstrated.
Coulometric Titrations with Electrolytically Generated Mercury(I and II) (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoulometric Titrations with Electrolytically Generated Mercury(I and II)E. P. Przybylowicz and L. B. RogersCite this: Anal. Chem. 1956, 28, 5, 799–802Publication Date (Print):May 1, 1956Publication History Published online1 May 2002Published inissue 1 May 1956https://pubs.acs.org/doi/10.1021/ac60113a006https://doi.org/10.1021/ac60113a006research-articleACS PublicationsRequest reuse permissionsArticle Views21Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A New Standstill Position Detection Technique for Nonsalient Permanent-Magnet Synchronous Motors Using the Magnetic Anisotropy Method (2007)

This paper describes a new method to estimate the standstill position of permanent-magnet synchronous motors (PMSMs). The method is based on the anisotropic properties of permanent magnets and is therefore referred to as a magnetic anisotropy method (MAM). It differs significantly from all standard standstill position detection methods previously presented in the literature. It is totally independent of saliency and saturation effects and can therefore be used in many types of PMSMs where the standard methods would fail. The paper fully explains the experimental results and briefly analyzes the physical phenomena behind the method
Nonlinear maneuvering and control of ships (2002)

We address the problem of maneuvering ships onto curves or paths in the plane. To do this, we introduce the Serret-Frenet equations and show how these fit the scope for control design with 3 degrees-of-freedom (DOF) hydrodynamic ship models in the loop. The Davidson and Schiff (1946) linear parametrically varying ship model is used in the design, and we show how we can manipulate this by introducing acceleration feedback and by moving the body-frame freely. This simplifies the control design in such a way that we do not have to deal with zero-dynamics. Instead we use a 3-step backstepping design and theory for interconnecting subsystems. Real data from a 175 m container ship is used in a computer simulation to validate the design.
Common Types of External Wall Insulation Systems and Their Performance Analysis (2010)

Several structural forms have appeared since the implementation on the related standards of exterior insulation and finish sys-tem(EIFS).Combining with actual utilization of insulation materials in civil engineering,the types of EIFS are classified with analysis on their performance.