gebhart/patrepeval huggingface dataset:
Risk factors of cervical neoplasia in a low income sector under control program in a developing country (2009)

1545 Background: There are a high number of risk factors (RF) in cervical neoplasias, most of them related with human papilloma virus infection: women with history of multiple sex partners (MSP), with early onset of sexual intercourse (EOSI),and non-previous cervical Papanicolaou (Pap) smear (NPAP).Objective: To determine the presence of RF in the studied population, the frecuency and types of lesions found, and the correlation between non-previous pap smear and underlying pathology. Methods: The population included in the study were 14,021 patients from institutions of public (PU) (n = 7523) and private (PRI) (n = 6499) sectors in the province of Tucumán–the average age being 34 and 43 years old, respectively–studied between 2007 and 2008, in a routine screening for CC with Pap testing. Both sectors include mostly low income people with none or limited health insurance. All testings were performed under methodologic norms of a CC Detection Program. The RF analized were: NPAP, EOSI, and MSP. Cervical lesions were studied with Bethesda System 2001. The statistic applied was the exploratory analysis. Results: NPAP in PU n = 4562 (75.76%), PRI n = 3247 (81.66%). EOSI with mean age being in PU 17 years old (sD 3.55) and PRI 19 (sD 5.33).MSP above 4 partners PU n= 482 (6.55%) PRI n= 161 (2.75%).Frecuency of LSIL in PU n= 30 (0,40%) PRI n = 50 (0.80%).HSIL in PU n = 29 (0.39%) PRI n = 28 (0.45%).Ca INV in PU n = 6 (0.08%) PRI n = 3 (0.05%). ASCUS in PU n = 24 (0.32%) PRI n = 10 (0.16%). Asociation between NPAP and cervical pathology was found p = 0.024 < 0.05 given that 100/142 (70.42%) patients with lesion had NPAP and 42/142 (29.57%) paitents had previous Pap. Conclusions: The results in this sample indicate low Pap coverture is mantained in PU and PRI sectors and the need to approach the population under 20 years old in Tucuman, Argentina, to prevent CC. No significant financial relationships to disclose.
In vivo characterization of the early states of the amyloid-beta network (2013)

Alzheimer's disease is a neurodegenerative disease that is associated with the abnormal accumulation of amyloid-β. Much is known about regional brain atrophy in Alzheimer's disease, yet our knowledge about the network nature of Alzheimer's disease-associated amyloid-β accumulation is limited. We use stepwise connectivity analysis of Pittsburgh Compound B positron emission tomography images to reveal the network properties of amyloid-β deposits in normal elderly subjects and clinical patients with Alzheimer's disease. We found that amyloid-β accumulation in the medial temporal lobe is associated with accumulation in cortical regions such as orbitofrontal, lateral temporal and precuneus/posterior cingulate cortices in Alzheimer's disease. In normal subjects, there was a predominant association between amyloid-β deposits in the hippocampus and the midline prefrontal/orbitofrontal regions, even in those with very low amyloid-β burden. Moreover, the orbitofrontal cortex, amygdala nucleus and hippocampus exhibit hub properties in the amyloid-β network that may be critical to understanding the putative spreading mechanisms of Alzheimer's disease pathology in early stages.
Reducing software security risk through an integrated approach research initiative model based verification of the Secure Socket Layer (SSL) Protocol (2003)

This document discusses the verification of the Secure Socket Layer (SSL) communication protocol as a demonstration of the Model Based Verification (MBV) portion of the verification instrument set being developed under the Reducing Software Security Risk (RSSR) Trough an Integrated Approach research initiative. Code Q of the National Aeronautics and Space Administration (NASA) funds this project. The NASA Goddard Independent Verification and Validation (IV&V) facility manages this research program at the NASA agency level and the Assurance Technology Program Office (ATPO) manages the research locally at the Jet Propulsion Laboratory (California institute of Technology) where the research is being carried out.
Formation of Femtosecond Parabolic Pulses in Normal-Dispersion Optical Fibers (2013)

We have shown through extensive numerical simulations that application of passive nonlinear reshaping in normal-dispersion optical fibers could produce femtosecond parabolic pulses (a few hundreds fs) modern femtosecond lasers and commercially available fibers.
Fluoro Ketones. II. Reaction of Amides with Fluoroacetones<sup>1</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluoro Ketones. II. Reaction of Amides with Fluoroacetones1P. E. Newallis and E. J. RumanowskiCite this: J. Org. Chem. 1964, 29, 10, 3114–3116Publication Date (Print):October 1, 1964Publication History Published online1 May 2002Published inissue 1 October 1964https://pubs.acs.org/doi/10.1021/jo01033a535https://doi.org/10.1021/jo01033a535research-articleACS PublicationsRequest reuse permissionsArticle Views92Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ALBA: An autonomic load balancing algorithm for IEEE 802.11 wireless networks (2008)

The widespread success of the WLAN technology raises the need for the efficient management of the different access points and the associated wireless devices, especially when multimedia and other QoS demanding applications are employed. In this paper we propose an autonomic load balancing mechanism for WLAN networks and test its applicability for a Voice over WLAN (VoWLAN) use case. The algorithm takes into account the channel utilization, the spatial distribution of wireless devices and the QoS requirements of user applications. The autonomic aspect of our algorithm is related to the use of a knowledge plane, which is a conceptual authority that entertains detailed runtime knowledge about the network state in terms of the load on each access point, as well as the connection speed and application QoS requirements of each wireless device. We use OPNET to evaluate the effectiveness of our management solution and load balancing algorithm. The paper presents the conducted simulations and ends by a critique of the general applicability of our algorithm and suggestions for future work.
Outcomes and Durability of Hepatic Reduction after Combined Partial Hepatectomy and Cyst Fenestration for Massive Polycystic Liver Disease (2016)

BACKGROUND: Partial hepatectomy and cyst fenestration (PHCF) selectively provides clinical benefit in highly symptomatic patients with polycystic liver disease (PLD). This study aims to ascertain whether the reduction in liver volume (LV) achieved by PHCF is sustained long term. STUDY DESIGN: Clinical data were retrieved from the electronic records of all patients with PLD who underwent PHCF between 1985 and 2014. Preoperative LVs (LV1), postoperative LVs (LV2), and late follow-up LVs (LV3) were measured from magnetic resonance or CT images. RESULTS: Among 186 patients who underwent PHCF, 91% were Caucasian women with autosomal dominant polycystic kidney disease with a mean age of 49 years. Major perioperative complications (Clavien III/IV) occurred in 21% of the patients. Operative mortality (<90 days) was 2.7%. Eleven patients had liver failure develop, received liver transplants, or had liver-related deaths. Overall survival was 95.7%, 93.3%, 85.6%, and 77.7% at 1, 5, 10, and 15 years respectively. Imaging records for volumetry were unavailable in 32 patients. Of the remaining 154 patients, 34 had imaging for 1 LV, 64 for 2 LVs, and 55 for all 3 LVs. Median LV was 6,781 mL (interquartile range 4,903 to 8,341 mL) preoperatively and 2,502 mL (interquartile range 2,089 to 3,136 mL) after PHCF, leading to a median postoperative LV reduction of 61%. At follow-up (mean 8 years), median LV was 2,519 mL (interquartile range 2,083 to 3,752 mL). Interestingly, 33 of 62 patients with available LV2 and LV3 showed additional regression in LV at follow-up (median −14.1%), and the rest showed mild growth of 9.9%. Overall volumetric comparison of preoperative with follow-up liver imaging showed sustained LV reduction (median 61%). CONCLUSIONS: Sustained long-term reductions in LV after PHCF can be achieved in selected patients with severe, highly symptomatic PLD. In our experience, liver-related death and subsequent liver transplantation are infrequent after PHCF.
Shear capacity of in service prestressed concrete bridge girders. (2010)

The design of prestressed concrete bridge girders has changed significantly over the past several decades. Specifically, the design procedure to calculate the shear capacity of bridge girders that was used forty years ago is very different than those procedures that are recommended in the current AASHTO LRFD Specifications. As a result, many bridge girders that were built forty years ago do not meet current design standards, and in some cases warrant replacement due to insufficient calculated shear capacity. However, despite this insufficient calculated capacity, these bridge girders have been found to function adequately in service with minimal signs of distress. The objective of this research was to investigate the actual in service capacity of prestressed concrete girders that have been in service over an extended period of time. The actual capacity was compared with calculated values using the AASHTO LRFD Specifications.
Visualization of Intracellular Movement of Vaccinia Virus Virions Containing a Green Fluorescent Protein-B5R Membrane Protein Chimera (2001)

We produced an infectious vaccinia virus that expressed the B5R envelope glycoprotein fused to the enhanced green fluorescent protein (GFP), allowing us to visualize intracellular virus movement in real time. Previous transfection studies indicated that fusion of GFP to the C-terminal cytoplasmic domain of B5R did not interfere with Golgi localization of the viral protein. To determine whether B5R-GFP was fully functional, we started with a B5R deletion mutant that made small plaques and inserted the B5R-GFP gene into the original B5R locus. The recombinant virus made normal-sized plaques and acquired the ability to form actin tails, indicating reversal of the mutant phenotype. Moreover, immunogold electron microscopy revealed that both intracellular enveloped virions (IEV) and extracellular enveloped virions contained B5R-GFP. By confocal microscopy of live infected cells, we visualized individual fluorescent particles, corresponding to IEV in size and shape, moving from a juxtanuclear location to the periphery of the cell, where they usually collected prior to association with actin tails. The fluorescent particles could be seen emanating from cells at the tips of microvilli. Using a digital camera attached to an inverted fluorescence microscope, we acquired images at 1 frame/s. At this resolution, IEV movement appeared saltatory; in some frames there was no net movement, whereas in others movement exceeded 2 microm/s. Further studies indicated that IEV movement was reversibly arrested by the microtubule-depolymerizing drug nocodazole. This result, together with the direction, speed, and saltatory motion of IEV, was consistent with a role for microtubules in intracellular transport of IEV.
Using Phase Space Reconstruction to Track Parameter Drift in a Nonlinear System (1997)

Abstract A model-based experimental method for tracking parameter drift in nonlinear dynamical systems is described. Local linear tracking models are constructed using data sampled over a fast time scale. These models are used to analyze data from systems with parameters which evolve over a slow time scale according to a “hidden” rate law. The method is applied to a numerical study of a nonlinear electrical circuit with a variable resistance as the drifting parameter. The mean-square tracking model prediction error is shown to follow successfully both ramped and sinusoidal parameter variations, suggesting that, at least in the cases studied, the method provides an invertible mapping between the parameter space and the observable space. Thus it should be possible to extract rate information about hidden drift, a requirement for true prediction.
Rathke's Cleft Cysts (2013)

Rathke cleft cysts are benign lesions that form from remnants of the embryologic Rathke pouch and are frequently identified in nearly one in six autopsies or healthy volunteers undergoing MRI. Athough usually asymptomatic, Rathke cleft cysts, particularly those whose contents are inflammatory, can cause symptoms like headaches, endocrine dysfunction, and, rarely, visual disturbances. Symptomatic Rathke cleft cysts warrant surgical resection, usually through a transsphenoidalendonasal corridor using either a microscope or an endoscope. While surgery is associated with minimal morbidity, the natural history of asymptomatic Rathke cleft cysts is one of slow growth, suggesting that observation through serial MRI is appropriate for smaller asymptomatic Rathke cleft cysts. For symptomatic Rathke cleft cysts, surgery provides good symptomatic relief of headaches and visual disturbance, and can even sometimes improve endocrine dysfunction.
Application of DC Electrical Method in Mine Water-inrush Forecasting (2007)

The author introduce the use of DC Electrical Method in forecasting coal mine water-inrush,for example,detecting forward geological structure,ploting out water-bearing conditions in face,circling the easier water-inrush area and valuating the fatalness of water-inrush in face etc.Most of explortion results have been verified by the mining practices.
Highly Electrically Conducting Glass-Graphene Nanoplatelets Hybrid Coatings (2015)

Hybrid coatings consisting of a heat resistant Y2O3-Al2O3-SiO2 (YAS) glass containing 2.3 wt % of graphene nanoplatelets (GNPs) were developed by flame spraying homogeneous ceramic powders-GNP granules. Around 40% of the GNPs survived the high spraying temperatures and were distributed along the splat-interfaces, forming a percolated network. These YAS-GNP coatings are potentially interesting in thermal protection systems and electromagnetic interference shields for aerospace applications; therefore silicon carbide (SiC) materials at the forefront of those applications were employed as substrates. Whereas the YAS coatings are nonconductive, the YAS-GNP coatings showed in-plane electrical conductivity (∼10(2) S·m(-1)) for which a low percolation limit (below 3.6 vol %) is inferred. Indentation tests revealed the formation of a highly damaged indentation zone showing multiple shear displacements between adjacent splats probably favored by the graphene sheets location. The indentation radial cracks typically found in brittle glass coatings are not detected in the hybrid coatings that are also more compliant.
P4–278: Clinical gamma‐secretase inhibitors (GSIs) alter beta‐amyloid 40/42 ratio in brain and show CSF beta‐amyloid rebound <i>in vivo</i> (2013)

To provide a detailed PK/PD in vivo assessment of gamma secretase inhibition in the search for clues to cognitive worsening in clinical trials. Wild type mice (129/sve) and tg2576 transgenic mice were assessed in acute multi-dose time course studies with LY-450139, BMS-708163, and GSI-953 examining A b lowering in brain, plasma, and CSF compartments in order to provide a PK/PD understanding of GSI inhibition. In brain A b levels were assessed in guanidine extracts with immunoassays configured for x-40 and x-42, while in plasma and CSF only the x-40 assay was used. In wt mouse, the efficacy at lowering brain A b x-40 always exceeded that of A b x-42, which resulted in a maximum drop in the ratio of A b 40/42 of 1.7, 2.5, and 2.95 for BMS-708163, LY-450139, and GSI-953, respectively. In tg2576 mouse, a similar phenomenon was observed in a head to head comparison of LY-450139 and BMS-708163 with a maximum ratio drop of A b 40/42 of 2.1 and 2.2, respectively. In addition to observing the plasma re-bound phenomenon, which is well documented, we also observed a similar phenomenon with the CSF compartment. In wild type mouse, LY-450139 showed a significant increase in A b x-40 at 130% of control. GSI-953 showed a non-significant trend increase of 128% of control, BMS-708163 did not display CSF re-bound. In our analysis of GS inhibition using an in vitro membrane assay we do not see an alteration in A b 40/42 ratio. Our data demonstrates that treatment of clinically relevant GSI's, alter the ratio of A b 40/42 in vivo, in both wild type and tg2576 mice, a phenomenon which is also observed with AD causing presenilin mutations. Further work is needed to evaluate this apparent disconnect between in vitro and in vivo A b alterations and how this may relate to the apparent cognitive worsening seen in the clinic with these compounds.
20205 Microassembly Using Surface Tension : 4^<th> report: Effects of Surface Tension on the Formation of Drops (2009)

A method of picking up a small component by using liquid surface tension is studied. In the previous works ultra-pure water was used as working fluid. This reports investigates on isopropanol (IPA) and its water mixtures. It is found that the maximum wetting angles increase as the ratio of IPA to water decreases and the adsorptive force decrease as the outer diameter of nozzle decrease.
Simulated annealing with restrained molecular dynamics using CONGEN: Energy refinement of the NMR solution structures of epidermal and type‐<i>α</i> transforming growth factors (1996)

The new functionality of the program CONGEN (Bruccoleri RE, Karplus M, 1987, Biopolymers 26:137-168; Bassolino-Klimas D et al., 1996, Protein Sci 5:593-603) has been applied for energy refinement of two previously determined solution NMR structures, murine epidermal growth factor (mEGF) and human type-alpha transforming growth factor (hTGF alpha). A summary of considerations used in converting experimental NMR data into distance constraints for CONGEN is presented. A general protocol for simulated annealing with restrained molecular dynamics is applied to generate NMR solution structures using CONGEN together with real experimental NMR data. A total of 730 NMR-derived constraints for mEGF and 424 NMR-derived constraints for hTGF alpha were used in these energy-refinement calculations. Different weighting schemes and starting conformations were studied to check and/or improve the sampling of the low-energy conformational space that is consistent with all constraints. The results demonstrate that loosened (i.e., "relaxed") sets of the EGF and hTGF alpha internuclear distance constraints allow molecules to overcome local minima in the search for a global minimum with respect to both distance restraints and conformational energy. The resulting energy-refined structures of mEGF and hTGF alpha are compared with structures determined previously and with structures of homologous proteins determined by NMR and X-ray crystallography.
ChemInform Abstract: Synthesis of Optically Active β,γ‐Unsaturated α‐Amino Acids and of α,β‐Unsaturated γ‐Amino Acids. SN2‐ vs. SN2′‐Dichotomy of the Mitsunobu Amination of Allylic Alcohols (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
[Human infection due to Streptococcus suis]. (2005)

2005年6月24日以来,我国四川省资阳市等地发生原因不明感染性疾病,患者以急性起病、高热、伴头痛等全身中毒症状,重者出现中毒性休克和脑膜炎为主要临床表现.根据病例的临床表现及流行病学调查和实验室检测结果,7月25日中国卫生部、农业部发出联合通报,初步诊断此次爆发性疫情是由猪链球菌血清2型(Streptococcus suis serotype 2)引起。
PEDF Regulates Vascular Permeability by a γ-Secretase-Mediated Pathway (2011)

Increased vascular permeability is an inciting event in many vascular complications including diabetic retinopathy. We have previously reported that pigment epithelium-derived factor (PEDF) is able to inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis through a novel γ-secretase-dependent pathway. In this study, we asked whether inhibition of VEGF-induced permeability by PEDF is also γ-secretase-mediated and to dissect the potential mechanisms involved. Vascular permeability was assessed in vitro by measuring transendothelial resistance and paracellular permeability to dextran and in vivo by following leakage of intravenous FITC-labelled albumin into the retina in the presence or absence of VEGF and PEDF in varying combinations. Experiments were undertaken in the presence or absence of a γ-secretase inhibitor. To assess junctional integrity immunohistochemistry for the adherens junction (AJ) proteins, VE-cadherin and β-catenin, and the tight junction (TJ) protein, claudin-5 was undertaken using cultured cells and flat mount retinas. Protein expression and the association between AJ proteins, VEGF receptors (VEGFRs) and γ-secretase constituents were determined by immunoprecipitation and Western Blot analysis. In selected experiments the effect of hypoxia on junctional integrity was also assessed. PEDF inhibition of VEGF-induced permeability, both in cultured microvascular endothelial cell monolayers and in vivo in the mouse retinal vasculature, is mediated by γ-secretase. PEDF acted by a) preventing dissociation of AJ and TJ proteins and b) regulating both the association of VEGF receptors with AJ proteins and the subsequent phosphorylation of the AJ proteins, VE-cadherin and β-catenin. Association of γ-secretase with AJ proteins appears to be critical in the regulation of vascular permeability. Although hypoxia increased VEGFR expression there was a significant dissociation of VEGFR from AJ proteins. In conclusion, PEDF regulates VEGF-induced vascular permeability via a novel γ-secretase dependent pathway and targeting downstream effectors of PEDF action may represent a promising therapeutic strategy for preventing or ameliorating increased vascular permeability.
The Effects of a Mould Inhibitor Based on Organic Acids and Salts on the Intestinal Strength of Broiler Chickens (1996)

Breaking of intestines during evisceration of broilers can cause faecal contamination and hence condemnation or reprocessing of the carcass. In this study, the effect of a mould inhibitor, based on a combination of organic acids and salts, on intestinal strength was determined. Broiler chickens were fed a commercial mash broiler feed, either treated with 5 kg liquid mould inhibitor per tonne, or untreated as a control. At 39 days of age, 25 cm segments of the intestines were collected and the breaking strength was measured on an Instron Universal Testing Machine. Three main observations were made in this study. First, there was no significant difference in breaking strength between the anterior and posterior parts of the intestine. Secondly, use of a mould inhibitor in broiler feeds improves intestinal strength, but this effect is not always statistically significant. And third, male broilers seem to respond better to the treatment than female broilers.