gebhart/patrepeval huggingface dataset:
A Comparative Study of Chitosan Gel and Soframycin in the Management of Wounds (2019)

Wounds and related injuries remain a major cause of death and disability. Healing of wound is a complex, highly regulated process that includes cellular, molecular, biochemical, and physiological events that permit living organisms to repair accidental lesions. Therefore, dealing with wounds has always been a subject of concern to the world, and demand for products in wound management had increased to $9.3 trillion worldwide in the health care industry, affecting economic growth. The present work aimed to assess the wound healing effect of chitosan, and a comparative profile with soframycin is established in experimental animals. Enormous research reports, the wound healing properties of chitosan, but the protective mechanism implicated in wound healing activity of chitosan is unknown. In addition to this, we evaluated the anatomical, macroscopical, and histopathological alterations in wounds of experimental rats. Collagenase activity was performed to determine the granulation tissue formation and epithelialization of wounds treated with untainted chitosan. Wounds treated with glycerated chitosan gel, that is, GCG-3 (high degree of deacetylation), showed faster healing with highest percentage of contraction as compared with the soframycin-treated group. The healing of wounds was found to be 85% in GCG-3 on the sixth day of treatment, showing significant (<i>P</i> < .001) improvement in epithelial tissue. The collagenase activity in GCG-3 was 192 unit/mg of protein. Wound reepithelialization was found to be to 94 ± 4% in case of the GCG-3-treated group and 87 ± 5% in the soframycin-treated group. Higher degree of deacetylation in the chitosan, GCG-3, warrants its use in the treatment and management of dermal wounds.
Persistence of Web references in scientific research (2001)

The lack of persistence of Web references has called into question the increasingly common practice of citing URLs in scientific papers. It is argued that although few critical resources have been lost to date, new strategies to manage Internet resources and improved citation practices are necessary to minimize the future loss of information.
Hederyne A, a new antimicrobial polyacetylene from galls of <i>Hedera rhombea</i> Bean (2007)

A new C(17)-polyacetylene, named hederyne A (1), has been isolated from the MeOH extract of galls of Hedera rhombea Bean (Araliaceae), together with two known polyacetylenes, falcarindiol (2) and 11,12-dehydrofalcarinol (3). The structure elucidation of 1 was achieved by NMR, MS, IR, and UV spectroscopy. Hederyne A (1) was a new C(17)-diacetylene containing 1,3-propanediol and exhibited selective antimicrobial activity against Micrococus luteus.
Mitochondrial profiling as a predictive biomarker for response to cytarabine-based treatment of acute myelogenous leukemia. (2016)

7017 Background: Acute Myelogenous Leukemia (AML) remains a poorly treated disease, which personalized medicine may improve by identifying the best therapy option based on a patient’s molecular or genetic makeup. To date, the best biomarkers in AML are based on cytogenetic risk category and age; however, these characteristics cannot accurately identify the best treatment option and are prognostic rather than predictive. One of the most promising predictive tests in AML involves the measurement of apoptotic sensitivities, as mitochondrial apoptosis induction is a hallmark for response to many treatment modalities. Methods: Mitochondrial profiling involves the perturbation of cells with specific BH3 (BCL2 Homology Domain 3) peptides, followed by flow cytometric measurements of their response in terms of induction of apoptosis. This method can be used to identify specific blocks of apoptosis present in leukemias at the single cell level. In a previous study, we identified that those AML patients most likely to respond to high dose ara-C (HiDAC) were highly primed for the BIM BH3 peptide. Here, we examined the relationship between BIM priming and complete remission (CR) and overall survival (OS) in patients treated with a standard ara-C based 7+3 regimen. Results: As with HiDAC treated patients, CR to 7+3 was significantly associated with BIM priming (p = 0.05), showing that it is an excellent predictor of response to the 7+3 regimen. BIM priming was also associated with longer OS (p = 0.049), with a positive predictive value of 80% and a negative predictive value of 70% using this single biomarker test. Additionally, BIM priming was additive to the cytogenetic risk category and age in predicting response, suggesting that BIM priming captures an additional dimension of AML biology that was not measured with cytogenetics and age. The BIM peptide has a broad binding range among the BCL-2 family members suggesting a general sensitivity to pro-apoptotic stimuli in the responsive leukemias. Conclusions: These results demonstrate that response and favorable outcomes are associated with the BIM biomarker, and this test can be used to identify patients that are most likely to respond to ara-C based therapies.
Vertebral body reconstruction for thoracolumbar spinal metastasis--a review of techniques. (2006)

The spine is the most common site of skeletal metastases with its involvement occurring in up to 40% of patients. Metastatic spinal involvement can cause a number of sequelae like pain, instability and neurologic compression. About 10% of patients with involvement of the vertebral column will subsequently develop neurologic compression.The metastatic spinal lesions mostly affect the vertebral body and pedicle (85%). Management of spinal metastases remains controversial. Recent reports attest to the beneficial role of surgery. The role of decompressive laminectomy without stabilization, has been questioned. The Involvement of Vertebral Body and anterior compression had led to an increasing attention to anterior decompressive procedures, reconstruction and Stabilization. We Review here the Techniques described in literature for anterior reconstruction after vertebral corpectomy.
Water–protein interactions from high–resolution protein crystallography (2004)

To understand the role of water in life at molecular and atomic levels, structures and interactions at the protein-water interface have been investigated by cryogenic X-ray crystallography. The method enabled a much clearer visualization of definite hydration sites on the protein surface than at ambient temperature. Using the structural models of proteins, including several hydration water molecules, the characteristics in hydration structures were systematically analysed for the amount, the interaction geometries between water molecules and proteins, and the local and global distribution of water molecules on the surface of proteins. The tetrahedral hydrogen-bond geometry of water molecules in bulk solvent was retained at the interface and enabled the extension of a three-dimensional chain connection of a hydrogen-bond network among hydration water molecules and polar protein atoms over the entire surface of proteins. Networks of hydrogen bonds were quite flexible to accommodate and/or to regulate the conformational changes of proteins such as domain motions. The present experimental results may have profound implications in the understanding of the physico-chemical principles governing the dynamics of proteins in an aqueous environment and a discussion of why water is essential to life at a molecular level.
Nanostructuring of Patterned Microelectrodes To Enhance the Sensitivity of Electrochemical Nucleic Acids Detection (2009)

Besser mit Ecken und Kanten: Die Elektroabscheidung von gemusterten Metallmikroelektroden auf einem Chip führt zu Biosensoren, deren Ansprechverhalten über den Grad der systematisch einstellbaren Oberflächenstrukturierung variiert werden kann (siehe Bild). Mikroelektroden mit stark nanostrukturierten Oberflächen erwiesen sich als empfindlicher als glatte Mikroelektroden. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
More Efficient Photolithographic Synthesis of DNA‐Chips by Photosensitization (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Diagnosis and management of achalasia (1999)

Vaezi, Michael F MD, PhD1; Richter, Joel E MD1 for the American College of Gastroenterology Practice Parameter Committee Author Information
Managing Wound Infection (1998)

Clinicians face many dilemmas when working with infected and non-healing wounds and there is still considerable debate as to what the aim of treating such patients should be. Should it be to eradicate specific pathogenic organisms? Or should it be to reduce the bacterial burden present in or on wounds?
Assignment of the hydroxyl bands in the infrared spectra of zeolites X and Y. Part 1.—Na—H zeolites (1973)

The infrared spectra of zeolites X and Y were recorded in the hydroxyl stretching region under high resolution conditions. The samples varied in their Al and proton content. The spectra were broken down into six different components. The selection of this number of components was based on reproducible details appearing in the high resolution spectra. An assignment for the different components is proposed, which considers the four different types of oxygen ions as possible sites for proton location. The narrow band at 3650 cm–1 is assigned to O1—H hydroxyl groups, while the broad and asymmetric band at 3550 cm–1 contains components due to O2—H, O3—H and O4—H groups.
How Latino Children in the U.S. Engage in Collaborative Online Information Problem Solving with their Families (2018)

Approximately 8 million U.S. children have at least one immigrant parent. Lower-socioeconomic (SES) immigrant parents often rely on their children's language skills to problem-solve family needs-a practice known as brokering. Yet it is unknown how children use their language and digital literacy skills to search and broker information online. This paper examines how children with lower-SES immigrant parents search and broker information online. We focused on Latino families as they are the fastest growing U.S. minority group. We conducted in-home interviews and observations of search tasks with 23 parent-child dyads. We demonstrate: (1) how Online Search and Brokering (OSB) is impacted by familial values and resources at an individual, family, community, and digital infrastructure level, and (2) through search vignettes, how parent-child dyads problem-solve family needs through OSB. Our work demonstrates a different purpose of technology use in families: intergenerational, bilingual, and online co-searching to problem-solve family needs.
Model for Directional Solidification of YBa<SUB>2</SUB>Cu<SUB>3</SUB>O<I><SUB>x</SUB></I> Superconducting Oxide (1992)

The unidirectional solidification by a zone melt method was performed in order to clarify the solidification mechanism of YBa2Cu3Ox (123) superconducting oxides. The continuous growth of 123 crystals were obtained under the growth rate less than 3 mm/h. A sharp faceted interface of 123 crystals was observed in the sample grown at 1 mm/h and the volume of the 211 phase decreased drastically from liquid into 123 crystal across the interface. From these results, we concluded that the necessary solute for peritectic reaction (211+liq.→123) is provided through a liquid. Based on this idea, we considered the driving forces for diffusion in liquid between the 211 particle and the growing interface, and developed a unidirectional solidification model. From this growth model, we can predict the balanced velocity of 123 growth and the distributions of 211 particles trapped in 123 crystal, and this model is in good agreement with the experimental results.
Dopamine Is Necessary for Cue-Dependent Fear Conditioning (2009)

Dopamine (DA) is implicated in many behaviors, including motor function, cognition, and reward processing; however, the role of DA in fear processing remains equivocal. To examine the role of DA in fear-related learning, dopamine-deficient (DD) mice were tested in a fear-potentiated startle paradigm. DA synthesis can be restored in DD mice through administration of 3, 4-dihydroxy-l-phenylalanine (l-Dopa), thereby permitting the assessment of fear processing in either a DA-depleted or -replete state. Fear-potentiated startle was absent in DD mice but could be restored by l-Dopa administration immediately after fear conditioning. Selective viral-mediated restoration of DA synthesis within the ventral tegmental area fully restored fear learning in DD mice, and restoration of DA synthesis to DA neurons projecting to the basolateral amygdala restored short-term memory but not long-term memory or shock sensitization. We also demonstrate that the DA D(1) receptor (D(1)R) and D(2)-like receptors are necessary for cue-dependent fear learning. These findings indicate that DA acting on multiple receptor subtypes within multiple target regions facilitates the stabilization of fear memory.
Network modulation in the treatment of Parkinson's disease (2006)

It has been proposed that deep brain stimulation (DBS) of the subthalamic nucleus (STN DBS) and dopaminergic therapy ameliorate the symptoms of Parkinson's disease through similar functional mechanisms. We examined this notion using PET to compare the metabolic effects of these treatment approaches. Nine Parkinson's disease patients (age 61.7 +/- 11.1 years) were scanned ON and OFF STN stimulation and nine others (age 60.0 +/- 9.3 years) were scanned ON and OFF an individual titrated intravenous levodopa infusion. The two treatment groups were matched for baseline disease severity as well as clinical response to therapy. Similarities and differences in the effects of treatment on regional metabolism were assessed using statistical parametric mapping (SPM). In addition, we used network analysis to assess the effect of therapy on the expression of an abnormal Parkinson's disease-related spatial covariance pattern (PDRP). We found that both STN DBS and levodopa therapy were associated with significant (P < 0.001) metabolic reductions in the putamen/globus pallidus, sensorimotor cortex and cerebellar vermis, as well as increases in the precuneus (BA 7). The metabolic effects of the two interventions differed in the STN and medial prefrontal cortex, with relative increases with stimulation in the former structure and decreases in the latter. Network quantification disclosed reductions in PDRP activity with both interventions, which correlated with clinical improvement (P < 0.05). The degree of network modulation by therapy did not differ significantly for the two treatment approaches (P > 0.6). These findings support the results of previous imaging studies indicating that effective symptomatic therapies for Parkinson's disease involve a common mechanism. The modulation of pathological brain networks is a critical feature of the treatment response in parkinsonism.
Dimensional magnetoplasma resonance of 2D holes in (001) GaAs/AlGaAs quantum wells (2000)

Dimensional magnetoplasma resonance is observed and studied in a spatially confined, two-dimensional hole system in (001) GaAs/AlGaAs single quantum wells. From the analysis of the field dependence of the magnetoplasma resonance on the diameter of the 2D system, the semiclassical cyclotron hole mass is determined. Its value is found to be equal to 0.26m 0 (m 0 is the free electron mass), which considerably exceeds the theoretically predicted value. A method is proposed for a direct determination of the concentration and mobility of 2D holes from the analysis of the magnetoplasma resonance.
Cloning, <i>in vitro</i> mitochondrial import and membrane assembly of the 17.8 kDa subunit of complex I from <i>Neurospora crassa</i> (1993)

We have cloned and sequenced a cDNA encoding a 17.8 kDa subunit of the hydrophobic fragment of complex I from Neurospora crassa. The deduced primary structure of this subunit was partially confirmed by automated Edman degradation of the isolated polypeptide. The sequence data obtained indicate that the 17.8 kDa subunit is made as an extended precursor of 20.8 kDa. Resistance of the polypeptide to alkaline extraction from mitochondrial membranes and the existence of a putative membrane-spanning domain suggests that the 17.8 kDa subunit is an intrinsic (bitopic) membrane protein. The in vitro synthesized precursor of the 17.8 kDa subunit can be efficiently imported into isolated mitochondria, where it is cleaved to the mature species by the metal-dependent matrix-processing peptidase. The in vitro imported mature subunit is found mainly exposed to the mitochondrial intermembrane space. However, a significant fraction of the imported polypeptide acquires the same membrane topology as the endogenous subunit, indicating that correct assembly in the mitochondrial inner membrane did occur.
Lactate in the foetal brain: detection and implications (2004)

Background and methods: In six hydrocephalic foetuses (gestational age 29–38 wk), proton MR spectroscopy (1H-MRS) was performed in the basal ganglia for detection of lactate in vivo. Results: Lactate was present in two foetal brains, absent in two and not detectable because of movement in two. Conclusion: With adequate immobilization of the foetus, 1H-MRS can be used for detection of foetal brain lactate.
Antibiotic Administration Early in Life Impairs Specific Humoral Responses to an Oral Antigen and Increases Intestinal Mast Cell Numbers and Mediator Concentrations (2006)

In this study, we assessed the effect of administering the antibiotic amoxicillin to rat pups on the immune response to orally fed ovalbumin (OVA). We first established that amoxicillin administration durably altered the gut microbiota of these animals. In parallel, we observed that the induction of the specific humoral response to ovalbumin was impaired when it occurred during antibiotic administration to the rat pups. We also examined the consequences of those observations on further allergic reactions. Amoxicillin administration had no significant impact on subsequent sensitization to OVA, as nonexacerbated systemic allergic responses were induced in antibiotic-treated animals. However, increased rat mast cell protease II levels and higher mast cell numbers were detected in their small intestines, independently of the antigen administration. Globally, our data suggest that antibiotic administration early in life negatively affects the specific immune response to a luminal antigen when it is first introduced during antibiotic administration. The increased mast cell numbers and mediator concentrations in the intestinal mucosae of the antibiotic-treated animals may testify to the early stages of an altered immune system homeostasis.
International Collaboration of Enterprise Stent-coiling (ICES) (2008)

INTRODUCTION: The development of self-expanding stents dedicated to intracranial use has significantly widened the applicability of endovascular therapy to many intracranial aneurysms (IAs) that would otherwise have been untreatable by endovascular techniques. Recent Food and Drug Administration approval of the Enterprise Vascular Reconstruction Device and Delivery System (Cordis, Miami Lakes, FL) has added a new option for self-expanding, stent-assisted IA coiling. METHODS: We established a collaborative registry across multiple institutions to rapidly provide large-volume results regarding initial experience using the Enterprise in real-world practice. Ten institutions (University at Buffalo, Thomas Jefferson University, University of Florida, Cleveland Clinic, Northwestern University, West Virginia University, University of Puerto Rico, Albany Medical Center Hospital, the Neurological Institute of Savannah, and the Barrow Neurological Institute) have provided consecutive data regarding their initial 3 to 6 months of experience with the Enterprise. RESULTS: In total, 141 patients (119 women) with 142 aneurysms underwent 143 attempted stent deployments. The use of Enterprise assist with aneurysm coiling was associated with an occlusion rate of at least 90% in 76% of cases. An inability to navigate or deploy the stent was experienced in 3% of cases, as well as a 2% occurrence of inaccurate deployment. Procedural data demonstrated a 6% temporary morbidity, 2.8% permanent morbidity, and 2% mortality (0.8% unruptured, 12% ruptured). CONCLUSION: We report initial results of the largest series to date utilizing the Enterprise for IA treatment. The Enterprise is associated with a high rate of successful navigation and low occurrence of inaccurate stent deployment. Overall morbidity and mortality were low; however, caution should be exercised when considering Enterprise deployment in patients with subarachnoid hemorrhage as our experience demonstrated a high rate of associated hemorrhagic complications leading to death.
High digitalized resolution and low switching loss for high power electronics converters based on multi-sampling technology (2009)

Digital control has been widely used in power electronics and its sampling rate is important to the control precision. Generally, faster the sampling rate is, closer the digital control is to that of its analog/original antetype. However, in most power electronics system, the sampling rate is commonly once or twice of the PWM switching frequency, which is vital for switching losses. This coupled relationship may result in conflict between high digitalized resolution and high efficiency, especially for high power applications. Multi-sampling technology is to sample the signal many times in one PWM period. Therefore, it doesn't need to increase the switching speed proportionally while fastening the sampling rate. This paper adopts the multi-sampling in an active power filter (APF) application. A logic method to deal with the problem during implementation due to the nature of digital controller is first proposed. Principle and implementation of this technology is discussed in detail. Analysis and experiment results show that the high compensation performance and low switching loss can be both achieved using the multisampling method.
Two-Dimensional Assembly Formation of Hydrophobic Helical Peptides at the Air/Water Interface: Fluorescence Microscopic Study (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo-Dimensional Assembly Formation of Hydrophobic Helical Peptides at the Air/Water Interface: Fluorescence Microscopic StudyKatsuhiko Fujita, Shunsaku Kimura, Yukio Imanishi, Elmar Rump, and Helmut RingsdorfCite this: Langmuir 1995, 11, 1, 253–258Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/la00001a043https://doi.org/10.1021/la00001a043research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts