gebhart/patrepeval huggingface dataset:
Optimisation techniques for advanced process supervision and control (2000)

This thesis is concerned with the use and development of optimisation techniques for process supervision and control. Two major areas related to optimisation are combined namely model predictive control and dynamic data reconciliation. A model predictive control scheme is implemented and used to simulate the control of a coal gasification plant. Static as well as dynamic data reconciliation techniques are developed and used in conjunction with steady-state optimisation and model predictive control schemes. The inaccuracy of process data due to measurement errors can be considerably reduced by data reconciliation techniques. This in turn improves process knowledge and control system performance. The static and dynamic data reconciliation techniques developed in this thesis are tested using dynamic models of process plants. In the steady-state case, a static data reconciliation algorithm that uses a static model of the process is implemented. This algorithm has capabilities of estimating measured variables, unmeasured variables, systematic bias and unknown physical parameters. The technique is applied to static optimisation to show the improvements in performance of the optimiser when using reconciled data. In order for static data reconciliation to be applied, it is necessary to employ a steady-state detection scheme since the underlying assumption is that the process is at steady-state. An algorithm for steady-state detection is implemented and tested in conjunction with the static data reconciliation technique. In the dynamic case, a moving horizon estimator that employs a dynamic model of the process is used to reconcile dynamic process data. An algorithm for the detection, identification and elimination of gross errors is implemented and tested. Furthermore, an algorithm for the detection and identification of systematic bias is developed and implemented. These techniques are then applied in combination to the dynamic model of a process. The effect of dynamic data reconciliation on the performance of model predictive control is observed by means of applying the above techniques to such a scheme. The various algorithms outlined above are implemented in software and tested using appropriate simulations. It is shown that it is possible to implement a steady-state detection algorithm and to successfully use it in conjunction with static data reconciliation. The application of static data reconciliation to steadystate optimisation shows a marked improvement in the performance of the optimiser. It is further shown that it is possible to combine bias and gross error detection and identification algorithms and to successfully apply them to dynamic data reconciliation procedures. The application of dynamic data reconciliation techniques to model predictive control shows improvement in the performance in cases where the objective is not purely economic.
Point of View (2001)

Professor of Orthopedic and Neurologic Surgery State University of New York Upstate Medical University Syracuse, New York
Current and Emerging Options in the Treatment of Onychomycosis (2013)

Currently approved options for the treatment of onychomycosis include systemic therapy (the antifungal agents fluconazole, itraconazole, and terbinafine), topical agents (ciclopirox, which has been available since 1996, efinaconazole, currently pending approval), and laser systems. Phase III studies on another topical, tavaborole, have been completed and this medication also shows promise. Mechanical modalities are sometimes used but are seldom necessary. Recurrence of infection is common; the risk for recurrence may be reduced by adherence to preventive measures, especially avoiding (if possible) or promptly treating tinea pedis infections.
Magnetic flux compression generator powered electron beam experiments (1986)

We have combined several technologies in a rather conservative fashion to perform feasibility experiments to power a vacuum, electron beam diode with an explosive power supply. The magnetic flux compression generator used in these experiments was the 13.2-cm-wide by 52.8-cm-long plate generator. The output of this device was switched into an air-core, foil-wound, step-up transformer with a turn ratio of 30:1. The transformer and diode were connected through a 9-m-long piece of Sieverts high-voltage cable. The diode structure consisted of a high-voltage terminal on a stacked-ring grading structure with a 5-cm-diameter stalk to support a 12.7-cm-diameter field emission cathode. The cathode-anode gap was 2.5 cm, and the anode was 6.35-micron--thick aluminized mylar. Currents of greater than or equal to14 kA and voltages of greater than or equal to540 kV were achieved with a pulse length of greater than or equal to100 ns. Theoretical predictions agree with experimental performance until the diode shorted. However, this event limited the ultimate performance of the experiments. We consider diode shorting to be a major problem to be dealt with in future experiments involving >1 ..mu..s power pulses. This approach to powering electron beams should prove useful for experiments requiring only a few events ormore » for very high-energy diode design and scaling tests. 11 figs.« less
La ecografía en el paciente trasplantado de riñón que no evoluciona bien…¿qué tengo que buscar? (2012)

Poster: SERAM 2012 / S-1169 / La ecografia en el paciente trasplantado de rinon que no evoluciona bien…?que tengo que buscar? by: Garcia Roch1, C. N. Cereceda Perez1, F. Garcia2, T. Fontanilla Echeveste2, A. Perez Martinez1, J. M. Pinto Varela1; 1Toledo/ES, 2Madrid/ES
Analysis of the PHA granule‐associated proteins GA20 .and GA11 in <i>Methylobacterium extorquens</i> and <i>Methylobacterium rhodesianum</i> (1997)

Electrophoretic analysis of the proteins bound to poly(3-hydroxybutyric acid), PHB-, granules in Methylobacterium extorquens, M. rhodesianum as well as the PHB-leaky mutants Mu 1 and Mu 11, which were isolated from the latter, resulted in two dominant low-molecular weight proteins, which were referred to as GA11 and GA20. After purification of these proteins antibodies against the GA11 and GA20 protein of M. extorquens were obtained. Both proteins bound to the surface of PHB granules as revealed by immunoelectron microscopy of whole cells of M. extorquens and M. rhodesianum. With cells of the PHB-leaky mutants Mu 1 and Mu 11 no specific labeling was observed. The N-terminal amino acid sequences of the GA11 and the GA20 protein were determined. We found significant homologies between the sequences of the investigated strains. The use of oligonucleotide probes based on the N-terminal sequences of the GA20 protein from M. rhodesianum to identify the corresponding structural genes in various genomic libraries failed.
Isolation of Skin Test-Active Preparations from Yeast-Phase Cells of <i>Blastomyces dermatitidis</i> (1974)

Cell wall and cytoplasmic fractions were isolated from mechanically disrupted yeast-phase cells of Blastomyces dermatitidis in an effort to obtain a reliable skin-test antigen. The biological activities of these fractions were compared with those of two blastomycin preparations. The cytoplasmic antigens exhibited a low index of specificity yet exceeded the specificities of the blastomycins. The skin test-active component(s) of the cytoplasmic material had a molecular weight between 10,000 and 30,000 and could easily be concentrated by ultrafiltration on a PM-10 membrane. Unlike the cytoplasmic antigens and blastomycins, an alkali-soluble, water-soluble cell wall antigen effectively distinguished guinea pigs that were sensitized to B. dermatitidis from those sensitized to Histoplasma capsulatum. The biological activity of the yeast-phase antigen could be quantitated, on a weight basis, after purification by ultrafiltration (PM-10 membrane).
Comparative Study of p53 Gene and Protein Alterations in Human Astrocytic Tumors (1993)

The p53 gene is a tumor suppressor gene involved in many common malignancies, including astrocytomas. Genetic analysis of the p53 gene and immunohistochemistry of the p53 protein have each been used to screen astrocytomas. To compare these methods, we performed immunohistochemistry with the monoclonal antibody PAb 1801 and single-strand conformational polymorphism (SSCP) with sequence analysis on 34 astrocytic tumors (WHO grades II, III and IV). Seven cases had detectable p53 protein and gene mutations, while twelve cases had neither detectable protein nor gene mutations. Four tumors had frameshift mutations in the p53 gene that were not revealed by immunohistochemistry. One tumor had a genetic polymorphism and no detectable p53 protein. Ten tumors had p53 protein accumulation but no mutations by SSCP; these cases may represent p53 mutations outside of the conserved exons or elevated levels of wild-type p53 protein. Thus, some p53 mutations are missed with PAb 1801 immunohistochemistry alone. p53 immunohistochemistry, however, may reveal p53 accumulation independent of mutations in the conserved portions of the gene. Finally, we suggest that glioblastomas with p53 mutations in the conserved region of the gene may be a subset that are more common in women and in younger patients.
HCV Entry and Neutralizing Antibodies: Lessons from Viral Variants (2009)

Evaluation of: Grove J, Nielsen S, Zhong J et al.: Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies. J. Virol. 82 (24), 12020-12029 (2008). Recent data suggest that a strong, early, broad neutralizing antibody response may contribute to the control of HCV in the acute phase of infection. However, the majority of individuals fail to clear HCV during the first months following infection and develop chronic infection despite the presence of anti-HCV antibodies. A prerequisite of the understanding behind the mechanisms of viral escape from antibody-mediated neutralization is the identification of various host-entry factors mediating the first steps of viral infection - binding and entry of HCV is believed to be a multistep process involving HCV envelope glycoproteins E1 and E2 as well as several host-cell surface molecules such as CD81, scavenger receptor class B type I, members of the claudin family and occludin. In this article, Grove et al. describe a single mutation in the HCV envelope glycoprotein E2 that alters glycoprotein structure thereby modulating viral interaction with scavenger receptor class B type I and CD81, and increasing sensitivity to neutralizing antibodies. The results of this study highlight the importance of the characterization of the interplay between HCV particles and host-cell factors for the understanding of virus neutralization by host-immune responses and pathogenesis of HCV infection.
Synthesis of organic-inorganic hybrid fillers at the molecular level and their application to composite resin. (2002)

The objective of this study was to synthesize a hybrid type filler composed of an organic component with inorganic component at the molecular level and to examine the properties of the filler. The composite resin was prepared by mixing synthesized filler with monomer and its physical properties were also examined. An organic-inorganic hybrid filler was synthesized by using 3-methacryloxypropyltrimethoxysilane (3-MPTS), methyltriethyoxysilane (MTES) and methanol silica sol. Firstly, poly3-methacryloxypropyltrimethoxysilane (poly3-MPTS) was synthesized by polymerization of 3-MPTS. A gelation product was obtained by graft-polymerization of poly3-MPTS with condensed organopolysiloxane after the hydrolysis of 3-MPTS, MTES and methanol silica sol. The gelation product was dried and ground to a filler. From the results of thermogravimetry-differential thermal analysis (TG-DTA), the organic-inorganic hybrid filler was found to be composed of 16.5 wt% organic component, 83.1 wt% inorganic component and 0.4 wt% residual water. A trial composite resin was prepared by mixing 55 wt% dimethacryloxyethyl 2,2,4-trimethylhexamethylene diurethane (UDMA), 15 wt% triethyleneglycol dimethacrylate (TEGDMA), 30 wt% 1-fluoro-1,3,3,5,5-penta (methacryloxyethyleneoxy) cyclotriphosphazene [P3N3(F)1 (EMA)5] as a base monomer and then 32.0 wt% of this monomer was mixed with 68.0 wt % of synthesized filler and a photo initiator, comphorquinone (CQ), was added. Compressive strength of the trial visible-light cured composite resin showed 397.0 MPa, and flexural strength and elastic modulus showed 142.5 MPa and 11.5 GPa, respectively. From the results, it was demonstrated that the present organic-inorganic hybrid filler at the molecular level can be used as a composite resin filler.
Effect of four-wave mixing on induced waveguiding (2000)

We study the waveguiding induced in a weak probe propagating in a medium of two-level atoms driven by a copropagating strong pump. We show that when the transverse profile of the pump exhibits solitonlike oscillations, similar oscillations can be induced in the transverse profile of the probe. When the probe waist size is initially narrower than that of the pump, the probe adjusts its width after a short propagation distance, to that of the pump. We show that the effect of the weak beam, which is created during propagation by four-wave mixing, on the waveguiding of the probe, becomes important when the medium is optically thick. This suggests that the importance of four-wave mixing in modifying induced waveguiding should be considered in other waveguiding schemes.
Using Model Checking for Pre-Planning Analysis (2001)

Planning domain descriptions contain many structural features, not made explicit by the domain designer but nevertheless present in the representation, that can be exploited by a planner to reduce search. We have explored the eect of a range of logical features, extracted during pre-planning analysis, on the search performance of both forward- and backward-searching planning systems and have conrmed that considerable planning-time benets can result from the use of ecient pre-planning analysis techniques. Domains involving time and other numeric quantities contain non-logical features which are harder to extract from a domain model. We have explored the combination of our existing pre-planning technology with standard model-checking approaches in order to extract temporal features of a planning domain that can improve planning performance. In this paper we explain how such domain features are extracted and how they can be exploited by the search strategy of a planne...
Further evaluation of N,N'-polymethylene-bridged 2-aminoethanethiol derivatives and related compounds as radioprotective agents (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFurther evaluation of N,N'-polymethylene-bridged 2-aminoethanethiol derivatives and related compounds as radioprotective agentsJames R. Piper, Carl R. Stringfellow Jr., and Thomas P. JohnstonCite this: J. Med. Chem. 1971, 14, 12, 1212–1217Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/jm00294a019https://doi.org/10.1021/jm00294a019research-articleACS PublicationsRequest reuse permissionsArticle Views185Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Propagation Characteristics of the Space Channel (1965)

International Telemetering Conference Proceedings / May 18-20, 1965 / Sheraton Park Hotel, Washington DC
Intersections of multiple cone classes for signal modeling and detection (2002)

The use of cone classes for signal detection and estimation is relatively new. Cone classes and the cone detector have shown potential as a viable alternative to subspace detection. The addition of new quadratic forms that model a wider range of signal characteristics, and the extension to using intersections of single cones, now makes it possible to apply cone classes to a wider range of practical problems. These extensions have resulted in a number of different types of intersection classes. Each type requires a different algorithm to implement the generalized likelihood ratio test (GLRT) used for signal detection. The authors classify these types and outline the possible solutions to implement the GLRT. New examples of signal classes modeled using cones are also given.
Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis (2011)

Dysregulation of microRNAs (miRNAs), particularly their downregulation, has been widely shown to be associated with the development of lung cancer. Downregulation of miRNAs leads to the overactivation of their oncogene targets, while upregulation of some miRNAs leads to inhibition of important tumor suppressors. Research has implicated cigarette smoke in miRNA dysregulation, leading to carcinogenesis. Cigarette smoke may lead to genetic or epigenetic damage to miRNAs, many of which map to fragile sites and some of which contain single nucleotide polymorphisms. Cigarette smoke may also cause dysregulation by affecting regulatory mechanisms controlling miRNA expression. Researchers have shown a correlation between smoke-exposure-induced dysregulation of miRNAs and age. Furthermore, dysregulation seems to be associated with intensity and duration of smoke exposure and duration of cessation. Longer exposure at a threshold level is needed for irreversibility of changes in expression. Better understanding of miRNA dysregulation may allow for improved biomonitoring and treatment regimens for lung cancer.
FATIGUE BEHAVIOR OF CEMENT-TREATED MATERIALS (1977)

Fatigue-failure criteria based on the Griffith failure theory have been developed to describe the behavior of cement-treated pavement materials subjected to repeated multiaxial stress applications. These criteria are represented by two relationships, one for curing periods of 4 weeks and the other for curing periods of 10 weeks, that show the variation of the maximum stress level as a function of the number of stress applications required to cause failure. The stress level is defined in terms of the applied principal stresses and the initial tensile strength. For a given set of applied stress pulses, there will be a maximum value of stress level. Fatigue failure occurs when the tensile strength decreases from its intitial value to the maximum value of the stress level. The number of stress applications to cause failure can thus be expressed as a function of the stress factor and the tensile strength. This relationship is independent of the duration and frequency of the applied stress pulses. The proposed criteria agree well with fatigue data from a number of investigations, which indicates their general validity.
Thermodynamically integrated buildings. [in-wall liguid heat exchangers for controlling building temperature] (1973)

A building structure is described wherein the walls, in thermal communication with the external atmosphere, are adapted to bear at least a portion of the loads imposed by the structure. The load bearing walls being formed by a plurality of contiguous, liquid tight, hollow panels, each panel including an outwardly facing wall portion in thermal communication with the external atmosphere and an inwardly facing wall portion spaced from the first and in thermal communication with the internal atmosphere of the building structure so that when an aqueous liquid flows through each panel such liquid is in direct contact with the respective inner surfaces of the outwardly and inwardly facing wall portions. Each of the panels includes an inlet means for the introduction of liquid therein and outlet means for the removal of the liquid. The inlet and outlet means of the panels are connected to provide flow of the aqueous liquid through the panels, pumping means for forcing the liquid through the panels, and heating or cooling means for maintaining the temperature of the aqueous liquid passing through the panels. By this means the load bearing walls are maintained substantially at a selected temperature to improve the stability of themore » building structure.« less
Interaction nutrition et reproduction : mécanismes centraux de régulation (1997)

National audience
Induction of allogeneic mixed chimerism by immature dendritic cells and bone marrow transplantation leads to prolonged tolerance to major histocompatibility complex disparate allografts (2009)

Mixed chimerism has been shown to lead to prolonged major histocompatibility complex (MHC) disparate allograft survival and immune-specific tolerance; however, traditional conditioning regimes often involve myeloablation, which may pose a significant safety risk. In this study we examined the use of donor C57BL/6 (H-2(b)) immature dendritic cells (imDCs) to tolerize the BALB/c (H-2(d)) recipient to bone marrow transplantation (BMT), allowing the induction of mixed chimerism without immunosuppression or myeloablation. We showed that successful mismatched bone marrow engraftment can be achieved using imDCs given up to 3 days prior to BMT and that mixed chimerism can be established and detected in excess of 100 days post-BMT without evidence of graft-versus-host disease. Furthermore, we showed that imDCs can suppress lymphocyte proliferation in response to mismatched MHC stimulation, leading to increased expression of interleukin (IL)-4 and IL-10 and decreased expression of IL-2 and interferon-gamma (IFN-gamma). The induction of stable chimeras through pre-conditioning of mice with donor imDCs followed by BMT led to tolerance, allowing the long-term survival (> 110 days) of mismatched cardiac allografts and the prolonged survival of mismatched skin allografts without the need for immunosuppression or myeloablation. Transplantation with third-party C3H allografts were rapidly rejected in this model, suggesting that immune-specific tolerance was achieved. The induction of immune-specific tolerance without the need for immunosuppression or myeloablation represents a significant advance in transplant immunology and may provide clinicians with a plausible alternative in combating organ rejection following transplantation.
Scanning X-Ray Or Extreme-Ultraviolet Monochromator (1991)

Wavelength of peak transmission of proposed high-throughput, narrow-band-pass x-ray or extreme-ultraviolet monochromator continuously adjustable. Essential filtering and reflecting components designed according to principles described in Compact X-Ray and Extreme-Ultraviolet Monochromator (MFS-28499). However, angle of incidence varied to change wavelength of Bragg reflection.