gebhart/patrepeval huggingface dataset:
Experimental and analytical performance evaluation of steel beam to concrete-encased composite column with unsymmetrical steel section joints (2017)

The seismic performance of steel beam to concrete-encased composite column with unsymmetrical steel section joints is investigated and reported within this paper. Experimental and analytical evaluation were conducted on a total of 8 specimens with T-shaped and L-shaped steel section under lateral cyclic loading and axial compression. The test parameters included concrete strength, stirrup ratio and axial compression ratio. The response of the specimens was presented in terms of their hysterisis loop behavior, stress distribution, joint shear strength, and performance degradation. The experiment indicated good structural behavior and good seismic performance. In addition, a three-dimensional nonlinear finite-element analysis simulating was conducted to simulate their seismic behaviors. The finite-element analysis incorporated both bond-slip relationship and crack interface interaction between steel and concrete. The results were also compared with the test data, and the analytical prediction of joint shear strength was satisfactory for both joints with T-shaped and L-shaped steel section columns. The steel beam to concrete-encased composite column with unsymmetrical steel section joints can develop stable hysteretic response and large energy absorption capacity by providing enough stirrups and decreased spacing of transverse ties in column.
Camera calibration: estimation, validation and software (2002)

The software tele2 3.1 allows, in particular, to measure the intrinsic parameters of a camera. Nevertheless, a single measure do not allow to characterize the distribution associated to a parameter. Moreover, if the way to obtain measures is incorrect, these measures may be outliers.Also, this document is made up of a method to measure the intrinsic parameters thanks to the software tele2 3.1, and to quantify the quality of the obtained values.An analysis of the experimental data is provided as well, allowing to validate the given method.
Nitric Oxide Is a Mediator of Methamphetamine (METH)‐Induced Neurotoxicity (1996)

METH is a monoaminergic toxic that destroys dopamine terminals in vivo. Oxidative mechanisms associated with DA metabolism are thought to play an important role in its toxic effects. These ideas were supported by the demonstration that CuZn-superoxide dismutase (CuZnSOD) transgenic mice were protected against the toxic effects of the drug. In the present study, we sought to determine if nitric oxide (NO) production was also involved in METH-induced neurotoxicity using primary cultures obtained from fetal rat mesencephalon. METH caused dose- and time-dependent cell death in vitro. Blockade of nitric oxide (NO) formation with several nitric oxide (NO) synthase blockers attenuated METH-mediated toxicity. Moreover, inhibition of ADP-ribosylation with nicotinamide and benzamide also provided protection against the toxicity of the drug. These results, together with our previous results in transgenic mice, support a role for free radicals in METH-induced toxic effects.
Overexpression and Hypomethylation of <i>Flap Endonuclease 1</i> Gene in Breast and Other Cancers (2008)

Flap endonuclease 1 (FEN1) is a structure-specific nuclease best known for its critical roles in Okazaki fragment maturation, DNA repair, and apoptosis-induced DNA fragmentation. Functional deficiencies in FEN1, in the forms of somatic mutations and polymorphisms, have recently been shown to lead to autoimmunity, chronic inflammation, and predisposition to and progression of cancer. To explore how FEN1 contributes to cancer progression, we examined FEN1 expression using 241 matched pairs of cancer and corresponding normal tissues on a gene expression profiling array and validated differential expression by quantitative real-time PCR and immunohistochemistry. Furthermore, we defined the minimum promoter of human FEN1 and examined the methylation statuses of the 5' region of the gene in paired breast cancer tissues. We show that FEN1 is significantly up-regulated in multiple cancers and the aberrant expression of FEN1 is associated with hypomethylation of the CpG island within the FEN1 promoter in tumor cells. The overexpression and promoter hypomethylation of FEN1 may serve as biomarkers for monitoring the progression of cancers.
A framework for building knowledge-bases under uncertainty (1999)

Abstract Managing uncertainty during the knowledge engineering process from elicitation to validation and verification requires a flexible, intuitive, and semantically sound knowledge representation. This is especially important since this process is typically highly interactive with the human user to add, update, and maintain knowledge. In this paper, we present a model of knowledge representation called Bayesian Knowledge-Bases (BKBs). It unifies a 'if-then' style rules with probability theory. We also consider the computational efficiency of reasoning over BKBs. We can show that through careful construction of the knowledge-base, reasoning is computationally tractable and can in fact be polynomial-time. BKBs are currently fielded in the PESKI intelligent system development environment. Keywords: Knowledge RepresentationReasoning Under UncertaintyProbabilistic ReasoningComplexity
Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review. (1998)

beta-blockade treatment was well tolerated and may be beneficial in relieving symptomatic steroid-induced left ventricular outflow tract obstruction in premature infants.
<i>N</i>-acetyl-<scp>d</scp>-glucosamine countertransport in lysosomal membrane vesicles (1990)

Countertransport of GlcNAc was examined in membrane vesicles prepared from rat liver lysosomes which had been lysed by exposure to 5 mM-methionine methyl ester. These vesicles have a random orientation, have intact ATP-dependent acidification and are largely free of soluble hydrolases. Vesicular volume (24.69 +/- 4.51 microliters/mg of protein) was greater than that of lysosomes (3.02 +/- 0.56 microliters/mg of protein), corresponding to a doubling of diameter. Characteristics of GlcNAc transport in vesicles (Km = 1.3 mM) were similar to those observed in intact lysosomes (Km = 4.4 mM). Sulphation or phosphorylation of the substrate resulted in loss of recognition by the carrier. Hydroxyl group orientation at multiple positions did not appear to be critical, whereas orientation of the acetyl group appeared to have a fundamental role in recognition by the carrier. Based on these criteria, phenyl isothiocyanate-GlcNAc (PITC-GlcNAc) was identified as a possible substrate for transport. Under mild conditions, PITC-GlcNAc reversibly inhibited GlcNAc countertransport in lysosomes and vesicles. This and other modified substrates may be of value in identification of the GlcNAc/GalNAc lysosomal transporter. Lysosomal membrane vesicle preparation is a technique that should be useful for the study of other lysosomal transport systems.
Reconstruction for proton computed tomography by tracing proton trajectories: A Monte Carlo study (2006)

Proton computed tomography (pCT) has been explored in the past decades because of its unique imaging characteristics, low radiation dose, and its possible use for treatment planning and on-line target localization in proton therapy. However, reconstruction of pCT images is challenging because the proton path within the object to be imaged is statistically affected by multiple Coulomb scattering. In this paper, we employ GEANT4-based Monte Carlo simulations of the two-dimensional pCT reconstruction of an elliptical phantom to investigate the possible use of the algebraic reconstruction technique (ART) with three different path-estimation methods for pCT reconstruction. The first method assumes a straight-line path (SLP) connecting the proton entry and exit positions, the second method adapts the most-likely path (MLP) theoretically determined for a uniform medium, and the third method employs a cubic spline path (CSP). The ART reconstructions showed progressive improvement of spatial resolution when going from the SLP [2 line pairs (lp) cm(-1)] to the curved CSP and MLP path estimates (5 lp cm(-1)). The MLP-based ART algorithm had the fastest convergence and smallest residual error of all three estimates. This work demonstrates the advantage of tracking curved proton paths in conjunction with the ART algorithm and curved path estimates.
Characterization of the v-<i>myb</i>DNA binding domain (1990)

The transforming protein encoded by the v-myb oncogene is a sequence-specific DNA-binding protein that is thought to be involved in the regulation of gene expression. The N-terminal region of the v-myb protein is composed of two highly conserved tandem repeat sequences of unknown function. It has been speculated that the N-terminal v-myb repeats might be crucial for DNA-binding, since N-terminal deletions destroy the DNA-binding activity of the v-myb protein. Here, we have studied the v-myb DNA-binding domain in more detail. Our results show that the N-terminal region of the v-myb protein is sufficient for specific DNA-binding. Dissection of this region suggests that both repeats are required for DNA-binding, but that both repeats play different roles in v-myb protein DNA interaction. We also show that the myb repeats of a drosophila melanogaster homolog of c-myb function as sequence-specific DNA-binding domain. Our results support the view that specific sequence-recognition, mediated by the conserved myb repeats, is a general feature of myb-related proteins.
A novel thermoelectric converter employing Fermi gas/liquid interfaces (1999)

It has been reported that the Peltier heat pumping rate of a thermoelectric converter can be increased by additional heat exchange at a Fermi gas/Fermi liquid (FG/FL) interface. This additional heat is associated with electron phase transitions between the Fermi gas and Fermi liquid. A practical configuration of a novel thermoelectric converter based on FG/FL interfaces is proposed and the possibility of improving the efficiency of a thermoelectric converter which employs this radically new approach is discussed.
Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors (2011)

These data demonstrated the frequent occurrence (34.9%) of PTEN loss of expression in colorectal cancers, for which gene mutations do not appear to be the main cause. Furthermore, dietary factors are not associated with loss of PTEN expression. PTEN expression negative CRC were not homogenous, as proximal cancers were associated with a more advanced Dukes' stage and poor differentiation, whereas distal cancers were associated with earlier Dukes' stage.
Effective governance is a critical factor for success of any microfinance institution in India-A review (2012)

Building good corporate governance is a continuous process that requires a long term vision. Good governance is central to institutional strengthening efforts and should be integrated with ongoing technical assistance and training initiatives. The MFIs have double goals, namely to act as the medium through which the poor can work their way out of poverty and to provide reasonable profits to their investors. These twin objectives can conflict unless a fair balance is maintained between both objectives. This makes it essential that MFIs have good systems of Corporate Governance. Good corporate governance should provide proper incentives for the board and management to pursue objectives that are in the interests of the company and its shareholders and should facilitate effective monitoring. Corporate Governance is also essential to institutional strengthening efforts and should be integrated with ongoing technical assistance and training initiatives. Foreign Institutional Investors (FII) find India very good market for investment but reluctant because of poor corporate governance. One needs to pierce the veil of the Corporates to reach the reality. This article is limited to secondary data only and a few case studies which show effective governance leads to success.
17.6 1V 10Gb/s/pin single-ended transceiver with controllable active-inductor-based driver and adaptively calibrated cascade-DFE for post-LPDDR4 interfaces (2015)

Performance improvements in mobile devices with multi-cores and enhanced graphics quality requires higher memory bandwidth. Consequently, the design of I/O becomes a crucial issue [1]. In the LPDDR interface, a ground-terminated interface is used for a low-noise termination voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ss</sub> ) and small I/O capacitance (C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">IO</sub> ) [2,3]. Even through noise margins and power efficiency are enhanced by ground termination, to compensate channel loss, the I/O is still the most power-hungry block. The pre-emphasized output driver and DFE are widely used to remove ISI and maximize read/write margins. However, multiple-taps in the output driver and the DFE are required to cover the channel loss, and they degrade the power efficiency of the I/O and occupy a large area.
Safety and Reliability Related Research and Teaching Activities at Liverpool JMU (2001)

"Safety and Reliability Related Research and Teaching Activities at Liverpool JMU." Safety and Reliability, 21(2), p. 124
A Synthesis of Sugar-modified S-Adenosyl-L-homocysteine (AdoHcy) Analogues as Inhibitors of AdoHcy Hydrolase (2005)

These syntheticefforts would thereby improve our understanding of thisenzyme, which can consequently could provide importantclues for the design of novel inhibitors. Among the reported compounds structurally related toAdoHcy, the modification in AdoHcy molecules is mainlyfocused on the amino acid and/or base moieties.
Role of enteral ebselen and ethylhydroxyethyl cellulose in pancreatitis-associated multiple-organ dysfunction in humans (2008)

Objective. Acute pancreatitis (AP) remains a severe disease responsible for the development of multiple organ dysfunction, and is associated with high mortality and morbidity. Early enteral nutrition has been suggested to have therapeutic potential for improving the outcome of AP patients. The aim of this study was to investigate whether supplementation of enteral nutrition with ebselen and ethylhydroxyethyl cellulose (EHEC) can attenuate the acute-phase responses and the severity of organ dysfunction in AP patients with either single- or multiple-organ dysfunction. Material and methods. AP patients with single-organ dysfunction (acute lung dysfunction) were treated with either vehicle (n=43) or the combination of ebselen and EHEC (n=48). AP patients with multiple-organ dysfunction (more than two organs) were treated with either vehicle (n=52) or the combination of ebselen and EHEC (n=55). Results. The combination of ebselen and EHEC significantly reduced the occurrence of infection (as indicated by a lower frequency of fever and a shorter duration of antibiotic use), improved gastrointestinal function (shorter period of bowel opening) and altered inflammatory responses by downregulation of circulating interleukin-6, monocyte chemoattractant protein-1 and interleukin-1 receptor in AP patients with single- or multiple-organ dysfunction, and improved the outcome of AP patients with multiple-organ dysfunction by reducing hospital stay and mortality. Conclusion. The combination of ebselen and EHEC is a new therapy with potential clinical benefit for the treatment of severe AP.
Free Vibrations of Viscoelastic Timoshenko Beams (1971)

The correspondence principle has been applied to derive the differential equations of viscoelastic Timoshenko beams with external viscous damping. These equations are solved by Laplace transform and boundary conditions are applied to obtain complex frequency equations and mode shapes for beams of any combination of end conditions. For beams without external damping, the correspondence principle can be applied directly to the available solutions of elastic Timoshenko beams. Numerical illustration is given.
The determination of plasma fibrinogen by the clot-weight method (1952)

Research Article| August 01 1952 The determination of plasma fibrinogen by the clot-weight method G. I. C. Ingram G. I. C. Ingram 1Department of Surgery, University of Edinburgh Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1952) 51 (5): 583–585. https://doi.org/10.1042/bj0510583 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation G. I. C. Ingram; The determination of plasma fibrinogen by the clot-weight method. Biochem J 1 August 1952; 51 (5): 583–585. doi: https://doi.org/10.1042/bj0510583 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1952 CAMBRIDGE UNIVERSITY PRESS1952 Article PDF first page preview Close Modal You do not currently have access to this content.
Gas-phase generation of singlet oxygen by reaction of ozone with organic substances (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas-phase generation of singlet oxygen by reaction of ozone with organic substancesW. C. Eisenberg, K. Taylor, and R. W. MurrayCite this: J. Am. Chem. Soc. 1985, 107, 26, 8299–8300Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://doi.org/10.1021/ja00312a101RIGHTS & PERMISSIONSArticle Views112Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (281 KB) Get e-Alerts Get e-Alerts
Manufacturing the truth: from designing clinical trials to publishing trial data (2017)

This paper expands on some of the points made by Deepak Natarajan on techniques used in designing clinical trials of new drugs to ensure favourable outcomes. It also considers the nexus between the manufacturers of new drugs and the publishers of medical journals in which edited versions of these favourable outcomes are presented to the medical fraternity. The argument will be illustrated by referring to the clinical trials of rofecoxib (Vioxx®) and etoricoxib (Arcoxia®). Both these drugs are COX-2 selective non-steroidal anti-inflammatory drugs (NSAIDs) manufactured by Merck and Co. Because of the unparalleled access to Merck's internal confidential documents, due to the subpoenaing of these documents by government and private individuals in civil and criminal actions, we are still learning about the company's unconscionable acts. What we learn can inform our judgement concerning published reports of both new and old drugs.
Sirolimus: Continuing the Evolution of Transplant Immunosuppression (2000)

The definitive role of sirolimus will continue to be determined; however, sirolimus offers an excellent addition to the transplant immunosuppression armamentarium.
The epidemiology of non‐alcoholic fatty liver disease (2017)

The increase in Non-alcoholic Fatty Liver Disease (NAFLD) and the imminent disappearance of chronic viral hepatitis thanks to new and effective therapies is motivating hepatologists to change their clinical approach to chronic liver disease. NAFLD-cirrhosis or NAFLD-Hepatocellular Carcinoma (HCC) are now the second cause of liver transplantation in the USA. This short-review is focused to the epidemiology of NAFLD/Non-alchoholic Steatohepatitis (NASH), including the definition of this disease which should be revised as well discussing the prevalence, risk factors for progression, natural history and mortality. NAFLD is considered to be the hepatic manifestation of the metabolic syndrome (MS). It affects 25-30% of the general population and the risk factors are almost identical to those of MS. The natural history involves either the development of cardiovascular diseases or cirrhosis and HCC. HCC can also develop in NASH in the absence of cirrhosis (45% of cases). We conclude that an international consensus conference on the definition, natural history, policies of surveillance and new pharmacological treatments of NAFLD and NASH is urgently needed.
George Box's contributions to time series analysis and forecasting (2014)

George Edward Pelham Box was born on October 19, 1919 in Gravesend, Kent, UK and died on March 28, 2013 in Madison, Wisconsin, USA. George Box made significant contributions to many fields of statistics including design of experiments and response surface methodology, evolutionary operation, statistical inference, robustness, Bayesian methods, time series analysis and forecasting, and quality improvement. Our paper discusses his contributions to time series analysis and forecasting. His work in this area started in collaboration with Gwilym Jenkins in the early 1960s and continued over the next several decades. His contributions include the classic and extraordinarily influential book ‘Time Series Analysis: Forecasting and Control’ written with Gwilym Jenkins and first published by Holden Day in 1970. Subsequent contributions to time series analysis include joint work with George Tiao, Gregory Reinsel, Daniel Pena, and many former graduate students. His work provided a unified framework for carrying out time series analysis in practice and laid the foundation for many new developments in the field. Copyright © 2014 John Wiley & Sons, Ltd.
Rho GTPases and the control of cell behaviour (2005)

Rho, Rac and Cdc42, three members of the Rho family of small GTPases, each control a signal transduction pathway linking membrane receptors to the assembly and disassembly of the actin cytoskeleton and of associated integrin adhesion complexes. Rho regulates stress fibre and focal adhesion assembly, Rac regulates the formation of lamellipodia protrusions and membrane ruffles, and Cdc42 triggers filopodial extensions at the cell periphery. These observations have led to the suggestion that wherever filamentous actin is used to drive a cellular process, Rho GTPases are likely to play an important regulatory role. Rho GTPases have also been reported to control other cellular activities, such as the JNK (c-Jun N-terminal kinase) and p38 MAPK (mitogen-activated protein kinase) cascades, an NADPH oxidase enzyme complex, the transcription factors NF-κB (nuclear factor κB) and SRF (serum-response factor), and progression through G1 of the cell cycle. Thus Rho, Rac and Cdc42 can regulate the actin cytoskeleton and gene transcription to promote co-ordinated changes in cell behaviour. We have been analysing the biochemical contributions of Rho GTPases in cell movement and have found that Rac controls cell protrusion, while Cdc42 controls cell polarity.