gebhart/patrepeval huggingface dataset:
Strategy for collaborative navigation in assistive robotics: Reducing user workload (2015)

Nowadays, physically impaired people (or people with special needs) still struggle with daily tasks when using mobility aid devices, whether for crossing doors, parking or manoeuvring. In this context, assistive robotics can offer solutions to those problems thus increasing the users' quality of life. In this work we propose a collaborative navigation strategy for predicting, and thus improving, the users' skills for driving assistive vehicles. In particular, two semi-autonomous navigation modes are presented, in which the vehicle is able to predict the user's motion intentions, reducing his/her workload. The systems were tested in a simulated environment with a population of seven volunteers, using a friendly interface and later validated in a real world scenario. Results showing that the system aids the user to safely navigate the environment and to decrease his/her workload are also included in this work.
Molecular basis of oocyte-paracrine signalling that promotes granulosa cell proliferation (2006)

Oocytes regulate follicle growth by secreting paracrine growth factors that act on neighbouring granulosa cells (GCs). Those factors identified to date are mainly members of the transforming growth factor-beta (TGFbeta) superfamily, but little is known about which specific receptor/signalling system(s) they employ. This study was conducted to determine the requisite pathways utilised by oocytes to promote GC proliferation. We used an established oocyte-secreted mitogen bioassay, where denuded mouse oocytes are co-cultured with mural GCs. Oocytes, growth differentiation factor-9 (GDF9), TGFbeta1 and activin-A all promoted GC DNA synthesis, but bone-morphogenetic protein 6 (BMP6) did not. Subsequently, we tested the capacity of various TGFbeta superfamily receptor ectodomains (ECD) to neutralise oocyte- or specific growth factor-stimulated GC proliferation. The BMP type-II receptor (BMPR-II) ECD antagonised oocyte and GDF9 bioactivity dose-dependently, but had no or minimal effect on TGFbeta1 and activin-A bioactivity, demonstrating its specificity. The TGFbetaR-II, activinR-IIA and activinR-IIB ECDs all failed to neutralise oocyte- or GDF9-stimulated GC DNA synthesis, whereas they did antagonise the activity of their respective native ligands. An activin receptor-like kinase (ALK) 4/5/7 inhibitor, SB431542, also antagonised both oocyte and GDF9 bioactivity in a dose-dependent manner. Consistent with these findings, oocytes, GDF9 and TGFbeta1 all activated SMAD2/3 reporter constructs in transfected GC, and led to phosphorylation of SMAD2 proteins in treated cells. Surprisingly, oocytes did not activate the SMAD1/5/8 pathway in transfected GCs although exogenous BMP6 did. This study indicates that oocyte paracrine factors primarily utilise a similar signalling pathway first identified for GDF9 that employs an unusual combination of TGFbeta superfamily receptors, the BMPR-II and a SMAD2/3 stimulatory ALK (4, 5 or 7), for transmitting their mitogenic actions in GC. This cell-signalling pathway may also have relevance in the hypothalamic-pituitary axis and in germ-somatic cell interactions in the testis.
What to do after nutrient removal? (2001)

In the Netherlands, interest in advanced treatment is increasing now that almost all wastewater treatment plants apply full biological treatment and nutrient removal. The resulting effluents have an excellent quality which can be improved further by applying advanced treatment processes like flocculating filtration, membrane filtration, UV or activated carbon, and others. The treated effluent can be re-used for various purposes, as process water, household water, urban water, for groundwater suppletion and drinking water. Nowadays many applications are investigated. In order to confirm the applicability pilot test investigations are done at various WWTPs. The results are promising; the cost estimations show increasing prospects. This will finally lead to the maturity of the advanced treatment. It will certainly contribute to a more sustainable water cycle.
Expression Patterns of Extracellular Matrix Components in Native and Cultured Normal Human Thyroid Tissue and in Human Toxic Adenoma Tissue (1997)

The extracellular matrix (ECM) and basement membranes (BM, a specialized form of ECM) greatly influence proliferation, differentiation, and function of cells and the structure of tissues. While a considerable amount of information is available on thyroid cellular proliferation, differentiation and function, much less is known about thyroid ECM and BM. In this study the presence of the ECM/BM components fibronectin, collagen IV, alpha1, beta1, gamma1 laminin, several laminin variants, osteonectin, and perlecan was demonstrated in cryosections of nonadenomatous and toxic adenoma human thyroid tissue. Also, positive immunohistochemical staining for collagen IV, laminin, perlecan, and fibronectin was obtained in sections of human thyroid tissue cultured in a three-dimensional (alginate) culture system. The present study provides methods and data that will facilitate the investigation of the interaction between cells and ECM in thyroid tissue.
Classification and Frequency of Cysts of the Oral and Maxillofacial Tissues (2007)

This chapter contains section titled: Classification Frequency of cysts of the oral regions
JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms (2016)

JMJD3 (Jumonji domain containing-3), a histone H3 Lys27 (H3K27) demethylase, has been reported to be involved in the antigen-driven differentiation of germinal center B-cells. However, insight into the mechanism of JMJD3 in DLBCL (Diffuse large B-cell lymphoma) progression remains poorly understood. In this study, we investigated the subtype-specific JMJD3-dependent survival effects in DLBCL. Our data showed that in the ABC subtype, silencing-down of JMJD3 inhibited interferon regulatory factor 4 (IRF4) expression in a demethylase activity-dependent fashion. IRF4 reciprocally stimulated expression of JMJD3, forming a positive feedback loop that promoted survival in these cells. Accordingly, IRF4 expression was sufficient to rescue the pro-apoptotic effect of JMJD3 suppression in the ABC, but not in the GCB subtype. In contrast, ectopic overexpression of BCL-2 completely offset JMJD3-mediated survival in the GCB DLBCL cells. In vivo, treatment with siRNA to JMJD3 reduced tumor volume concordant with increased apoptosis in either subtype. This suggests it is a common target, though the distinctive signaling axes regulating DCBCL survival offer different strategic options for treating DLBCL subtypes.
Surface Coordination Chemistry of YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7-</sub><sub>δ</sub> (1998)

The surface coordination chemistry of the cuprate superconductor, YBa2Cu3O7-δ has been extensively surveyed using cyclic voltammetry in conjunction with a series of redox-active ferrocenyl containing adsorbate molecules. Evidence supporting the adsorption of molecules with primary alkylamine, secondary alkylamine, tertiary alkylamine, arylamine, thiol, disulfide, and selenol functionalities is reported. Cyclic voltammetry, atomic force microscopy, scanning electron microscopy, X-ray powder diffraction and resistivity vs temperature measurements were utilized to evaluate the influence of the modification conditions on the bulk and surface properties of the high-Tc superconductor. The spontaneous adsorption of redox-active alkylamines, arylamines, and thiols onto the surfaces of cuprate materials has been shown to produce stable and robust monolayer films with no apparent damage to the bulk properties of the underlying superconductors. Of the molecules studied thus far, primary alkylamines have been determined to be the optimum adsorbates based upon surface coverage values and monolayer durability. Tertiary alkylamines form monolayers on YBa2Cu3O7-δ with an electrochemical persistence comparable to primary alkylamine monolayers, suggesting that hydrogen binding with the surface is not necessary for adsorption. We propose that amines act as Lewis bases and bind to Lewis acidic Cu surface site(s) in YBa2Cu3O7-δ to form stable coordination bond(s).
Immunohistologic expression of blood‐group antigens in normal human gastrointestinal tract and colonic carcinoma (1986)

A panel of 7 mouse monoclonal antibodies and the lectin from Ulex europeus, detecting blood-group-related antigens of the ABH and Lewis systems, have been used to define the distribution of these antigenic structures within the human gastrointestinal tract, and to characterize their expression and modulation in colorectal carcinomas. The reagents employed detect the following blood-group specificities: A (all variants), B, H (type 2), Lewisa, Lewisb, X (Lewisx), Y (Lewisy) and type 1 precursor chain. Immunohistochemical studies demonstrate that these antigens are differentially expressed in various cell types and developmental stages of the human gastrointestinal tract. ABH expression undergoes developmental modulation in the human colorectal tract from positive to negative during embryogenesis, and is lost in adult cells. Colorectal tumors exhibit neosynthesis of ABH specificities that appear in tumor cells, and accumulation of the precursor antigens. They also show increased expression of Lewis antigens, especially Y determinant, which has a restricted pattern of distribution in normal tissues and is not found in normal colonic mucosa. Enhancement of the Lewis antigens is observed in all colorectal tumors analyzed, regardless of blood-group type and secretory status of the individuals studied. Tumor modulation of these antigens may be related to activation of suppressed genes and enhancement of fucosyltransferases.
In vitro activity of the siderophore monosulfactam BAL30072 against meropenem-non-susceptible Acinetobacter baumannii (2012)

BAL30072 is a promising new agent with good activity against carbapenem-non-susceptible A. baumannii.
Focal Gains of <i>VEGFA</i> and Molecular Classification of Hepatocellular Carcinoma (2008)

Hepatocellular carcinomas represent the third leading cause of cancer-related deaths worldwide. The vast majority of cases arise in the context of chronic liver injury due to hepatitis B virus or hepatitis C virus infection. To identify genetic mechanisms of hepatocarcinogenesis, we characterized copy number alterations and gene expression profiles from the same set of tumors associated with hepatitis C virus. Most tumors harbored 1q gain, 8q gain, or 8p loss, with occasional alterations in 13 additional chromosome arms. In addition to amplifications at 11q13 in 6 of 103 tumors, 4 tumors harbored focal gains at 6p21 incorporating vascular endothelial growth factor A (VEGFA). Fluorescence in situ hybridization on an independent validation set of 210 tumors found 6p21 high-level gains in 14 tumors, as well as 2 tumors with 6p21 amplifications. Strikingly, this locus overlapped with copy gains in 4 of 371 lung adenocarcinomas. Overexpression of VEGFA via 6p21 gain in hepatocellular carcinomas suggested a novel, non-cell-autonomous mechanism of oncogene activation. Hierarchical clustering of gene expression among 91 of these tumors identified five classes, including "CTNNB1", "proliferation", "IFN-related", a novel class defined by polysomy of chromosome 7, and an unannotated class. These class labels were further supported by molecular data; mutations in CTNNB1 were enriched in the "CTNNB1" class, whereas insulin-like growth factor I receptor and RPS6 phosphorylation were enriched in the "proliferation" class. The enrichment of signaling pathway alterations in gene expression classes provides insights on hepatocellular carcinoma pathogenesis. Furthermore, the prevalence of VEGFA high-level gains in multiple tumor types suggests indications for clinical trials of antiangiogenic therapies.
Sensory changes in the territory of the lingual and inferior alveolar nerves following lower third molar extraction (1998)

Post-injury inflammation activates nociceptive systems and recruits normally non-nociceptive afferents into a pain processing role. During inflammation, Abeta low threshold mechanoreceptor afferents that usually mediate tactile sensation acquire properties of nociceptors, allowing them to participate in post-injury spontaneous pain and evoked abnormalities such as tenderness and pain to light touch. This study assessed the sensory consequences of post-injury inflammation following extraction of a single, lower third molar tooth. Extensive bilateral evaluations were performed in the territory of nerves assumed to be exposed to both inflammation and mechanical trauma, inflammation alone, or only the central consequences of peripheral inflammation. Testing at the distal termination of nerves assumed to be exposed to local inflammation (mental and lingual nerve territory) revealed decreased detection thresholds (P < 0.05) to electrical stimulation and to mechanical stimulation by sensitive, disposable filaments developed and validated for this application. Testing at sites of assumed inflammation and mechanical trauma (mental nerve territory) showed reduced pain thresholds to electrical stimulation. Thermal detection and pain thresholds were not altered at any location in patients, and no effects were observed in control subjects receiving only local anesthetic injections. These results in humans are consistent with recent experimental evidence that inflammatory processes alter the central consequence of activity in large-diameter Abeta touch primary afferents evoked under natural conditions by gentle mechanical stimulation. These effects result in hyperesthesia, increased sensitivity to light touch, and mechanical allodynia, pain evoked by normally innocuous stimulation of Abeta primary afferents.
The Rho Guanine Nucleotide Exchange Factor Syx Regulates the Balance of Dia and ROCK Activities To Promote Polarized-Cancer-Cell Migration (2013)

The role of RhoA in promoting directed cell migration has been complicated by studies showing that it is activated both in the front and the rear of migrating cells. We report here that the RhoA-specific guanine nucleotide exchange factor Syx is required for the polarity of actively migrating brain and breast tumor cells. This function of Syx is mediated by the selective activation of the RhoA downstream effector Dia1, the subsequent reorganization of microtubules, and the downregulation of focal adhesions and actin stress fibers. The data argue that directed cell migration requires the precise spatiotemporal regulation of Dia1 and ROCK activities in the cell. The recruitment of Syx to the cell membrane and the subsequent selective activation of Dia1 signaling, coupled with the suppression of ROCK and activation of cofilin-mediated actin reorganization, plays a key role in establishing cell polarity during directed cell migration.
Denoising of electron beam Monte Carlo dose distributions using digital filtering techniques (2000)

A printed error has been discovered on pages 1771 and 1772 of the above paper. Figures 4 and 5 should have been the other way around (the captions were correct as printed). For the correct version see the electronic journal.
On the scheduling of real-time multihop packet-switching networks (2002)

The purpose of the paper is to present a method to validate tentative routes to establish calls with end-to-end timing-constraints in a multihop packet-switching network. Timing release counters are proposed as a mechanism to guarantee that intervals between consecutive releases of messages of the same call are not shorter than the call period. A comparative evaluation of the proposed timing release counters vs. the alternative method of stop-and-go queues is performed.
Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile (2005)

Smad2 and Smad3 are closely related effectors of TGFbeta/Nodal/Activin-related signaling. Smad3 mutant mice develop normally, whereas Smad2 plays an essential role in patterning the embryonic axis and specification of definitive endoderm. Alternative splicing of Smad2 exon 3 gives rise to two distinct protein isoforms. The short Smad2(Deltaexon3) isoform, unlike full-length Smad2, Smad2(FL), retains DNA-binding activity. Here, we show that Smad2(FL) and Smad2(Deltaexon3) are coexpressed throughout mouse development. Directed expression of either Smad2(Deltaexon3) or Smad3, but not Smad2(FL), restores the ability of Smad2-deficient embryonic stem (ES) cells to contribute descendants to the definitive endoderm in wild-type host embryos. Mice engineered to exclusively express Smad2(Deltaexon3) correctly specify the anterior-posterior axis and definitive endoderm, and are viable and fertile. Moreover, introducing a human Smad3 cDNA into the mouse Smad2 locus similarly rescues anterior-posterior patterning and definitive endoderm formation and results in adult viability. Collectively, these results demonstrate that the short Smad2(Deltaexon3) isoform or Smad3, but not full-length Smad2, activates all essential target genes downstream of TGFbeta-related ligands, including those regulated by Nodal.
Rydberg states of the Ar2 molecule (1992)

Extensive spectra attributable to transitions from the 4sσ a 3Σ+ metastable state of Ar2 to excited Rydberg states have been observed by intracavity absorption spectroscopy and by laser excitation spectroscopy in the afterglow of a pulsed corona discharge. Of these the most extensive and best resolved were the laser induced fluorescence spectra. Most of the spectra can be assigned to vibronic transitions in the nfλ (3Πg,3Σ+g) and npλ (3Πg,3Σ+g)←a 3Σ+u series. The 5pπ3Πg←a 3Σ+u and 7pσ 3Σ+g←a 3Σ+u transitions observed near 19 823 and 19 529 cm−1, respectively, exhibit many bands with v′≠0 in their (v′–v″) vibrational band system developments. The higher n value members of these and other observed series are dominated by (0–0) transitions. Rotational structure is partially resolved in a few bands of the 7pσ 3Σ+g–a system, but most of the spectra observed appear to be either rotationally unresolved or made up of blended collections of rotational lines. Above the 7pσ, 5pπ pair, the (n+2)pσ 3Σ+g and npπ 3Πg members of the npλ series rapidly coalesce, indicating a rapid onset of decoupling of the electronic orbital angular momentum, L̂, from the internuclear axis. Such decoupling leads to np-complex formation at n values much lower than observed in the npλ series of the lighter dimers: He2 and Ne2. From the data for the observed series, the lowest ionization limit of Ar2 (relative to a 3Σ+u,v=0 ) was determined to be 29 373±3 cm−1. Vibrational intervals ΔG(v+1/2) for a 3Σ+u(v≤4) and 7pσ 3Σ+g(v≤2) yield the vibrational constants ωe=296 and 282 cm−1 and xωe=2.5 and 17 cm−1, respectively.
Etude de la réactivité de décharges électriques nanoseconde à la pression atmosphérique dans la vapeur d'eau (2014)

Plasma discharges in water vapor are of great interest for a variety of potential applications, such as biomedical treatment, hydrogen production, or plasma assisted combustion. This thesis proposes a detailed experimental characterization of the thermal and chemical effects of non thermal discharge, particularly Nanosecond Repetitively Pulsed (NRP) discharges at atmospheric pressure in pure water vapor. A reactor has been designed to operate with water vapor preheated at 400-500 K. We investigated the various discharge regimes and the operating conditions for each regime. The selected operating conditions are a flow rate of 300 g/h at 500 K. The discharge has an average energy from 20 to 100 W in the spark regime. Various diagnostics have been developed in order to infer the products of this discharge in terms of intermediate species, electrons, and stable products. The concentration of the reaction products (H2 and O2) and their respective flow rates were measured using gas chromatography. A maximal value of 0.85 g- H2/kWh was obtained. The electron number density has been measured using time-resolved optical emission spectroscopy (OES) via Stark-broadened lines (H, H and O). The maximum measured electron density is 2X1018 cm-3 during the pulse, and a slow recombination process was observed. The gas temperature was measured during the 20-ns discharge by OES as well as between two discharges (100 us) by two-color OH-Planar Laser Induced Fluorescence (OH-PLIF). The maximum temperature elevation is 950 K after the pulse ; the temperature then decays exponentially with a characteristic time of 5 us. Between two successive discharges, the relative density of the OH radical was measured by OH-PLIF. An interesting result is the relatively long-lived nature of OH, with a 1/e decay time of about 50 us. Using a 0D-chemical kinetics model, the absolute OH density at the end of the pulse was estimated to 400 more or less 200 ppm. These results provide useful information to better understand the mechanisms underlying the generation of NRP spark discharges in low temperature pure water vapor.
Regulatory Properties of the Pyruvate-Dehydrogenase Complex from Escherichia coli. Thiamine Pyrophosphate as an Effector (1974)

The pyruvate dehydrogenase complex from Escherichia coli is subject to an allosteric control. Pyruvate shows a homotropic cooperative effect. The extent of the cooperativity increases with decreasing concentrations of thiamine pyrophosphate. This cofactor itself exhibits positive cooperativity in steady-state measurements. The saturation curves both of pyruvate and of thiamine pyrophosphate have a very unusual asymmetric shape. The sigmoidal range is limited to low ligand concentrations and changes to a hyperbolic form far below half saturation. It was demonstraed that allosteric systems with more than eight interacting protomers, which obeys the allosteric model of Monod, J., Wyman, J., and Changeux, J.-P. [J. Mol. Biol. 12 (1965) 88–117], behave in this manner. In the absence of substrate and thiamine pyrophosphate, the pyruvate dehydrogenase exists in an inactive form. At low thiamine pyrophosphate concentrations addition of pyruvate leads, after a lag phase of several minutes, to a partial activation. Within less than one second, complete activation occurs when saturating amounts of thaiamine pyrophosphate are added, irrespective of the presence or absence of pyruvate. The lag period increases with decreasing degree of enzyme dilution. This phenomenon is not due to a dissociation and reassociation of subunits.
Analysis of electric and magnetic fields leaking from induction heaters (1988)

Results are presented of an investigation on electric and magnetic fields leaking from inductive (magnetic) heaters that are used for thermal processing of high-power electron tubes and lasers in an industrial plant. Measurements of electric and magnetic fields were done using both commercially available and laboratory-developed instrumentation. Isotropic H-field sensors were developed to allow quantitative evaluation of high-intensity magnetic fields. Ten induction heaters with nominal A.C. power ranging from 2.5 kW to 15 kW and operating at frequencies between 300 kHz and 790 kHz were surveyed. Electric field strengths up to 8 kV/m and magnetic field strengths up to 20 A/m were measured.
Improving production using re-entry drilling techniques (1996)

Cost-effective production improvement has been an industry focus for the past several years. Fracturing, stimulating, re-perforating and recompleting existing wells are all widely used methods with proven results to increase the net present value of old fields. Now re-entry drilling is generating high interest because of its potential to improve recovery from damaged or depleted zones or tap into new zones at low cost. Re-entry drilling has the advantage of starting with a fair-to-good background of information on the producing formation as well as a working conductor to the target reservoir. The paper discusses recognizing the candidates, the economics of re-entry drilling, and successful re-entry of old wells.