gebhart/patrepeval huggingface dataset:
Non-local manifold tangent learning (2005)

We claim and present arguments to the effect that a large class of manifold learning algorithms that are essentially local and can be framed as kernel learning algorithms will suffer from the curse of dimensionality, at the dimension of the true underlying manifold. This observation suggests to explore non-local manifold learning algorithms which attempt to discover shared structure in the tangent planes at different positions. A criterion for such an algorithm is proposed and experiments estimating a tangent plane prediction function are presented, showing its advantages with respect to local manifold learning algorithms: it is able to generalize very far from training data (on learning handwritten character image rotations), where a local non-parametric method fails. 1
Software for the Armstrong multiprocessor. Technical report (1987)

This report addresses some of the problems involved in building parallel processors, focusing on the Armstrong multiprocessor. It describes the Armstrong hardware, the system software, and kernel services related to process management and those related to communication. It presents some preliminary data relating to the performance of the Armstrong input/output system, and briefly discusses two applications to give examples of system performance relationships. The first application, which is easy to parallelize and has low I/O requirements, computes and displays an image of a fractal, the Mandelbrot set. The second, more-difficult, application computes the two-dimensional discrete Fourier transform of an image for display, and can be used in image analysis and image coding and has characteristics typical of large scientific matrix/vector calculations.
Protocols And Data For Heterosigma Akashiwo Transformation Approaches (2017)

This dataset provides information about plasmid construction, antibiotic sensitivity and transformation approaches for the algal species, <em>Heterosigma akashiwo</em>. <strong>Note that protocols for glass bead-mediated transformation and electroporation of <em>Heterosigma akashiwo</em> have been updated. Please see http://dx.doi.org/10.17504/protocols.io.hjkb4kw and http://dx.doi.org/10.17504/protocols.io.hjmb4k6.</strong>
Teambotica (2003)

Teambotica is a research environment for the exploration of theories, designs and implementations of team-based robotics. In developing Teambotica, we found that many of the simplifying assumptions that are often taken in both multiagent systems and behavior-based robotics had to be discarded. Central to our approach is a multilevel agent architecture which is adaptive along a number of dimensions and which is based on a vertically integrated design that spans a wide range of operations, from team-level reasoning to low-level control. The design addresses a number of pertinent issues: the proper mix of deliberation and action, flexible networking support including planning for communications, adaptive task level control, team-based monitoring, and an open systems modularity that takes form-factor considerations seriously. We also describe simulation tools for development and discuss several robotic teams that we have demonstrated.
Occurrence of nonenzymatic N‐acetylation of sphinganine with acetyl coenzyme a producing C2‐H2‐ceramide and its inconvertibility to apoptotic C2‐ceramide (1997)

Sphinganine, a biosynthetic precursor of ceramide, was non-enzymatically acetylated with acetyl coenzyme A at the C-2-amino residue to produce C2-H2-ceramide (N-acetyl sphinganine) in an organic solvent and in an aqueous solution with a high yield, whereas sphingenine was only acetylated slightly. The structure of the N-acetyl sphinganine was identified with mass spectrum, and with chromatography using an authentic N-acetylated substance. Furthermore, the C2-H2-ceramide was examined for enzymatic desaturation to determine whether C2-ceramide, a cell-permeable ceramide responsible for apoptosis of cells, was produced, revealing an inferior substrate for H2-ceramide desaturase of horse brain microsomes.
Subdural Hematoma in Hemophilia: Successful Treatment with Cryoprecipitate (1968)

I NTRACRANIAL hemorrhage is the most dreaded complication of hemophilia and is now the leading cause of death in this disease2 ,1~ Silverstein, lz reviewing the world literature to 1960, reported a mortality of 71%. In his series, eight of 30 patients were treated with surgical intervention 11 times with only two survivals. With recent advances la,l~ which allow the production of low volume, extremely potent concentrates of Factor viii (anti-hemophiliac globulin, or AHG), the outlook for survival and successful surgical intervention in classical hemophilia is greatly improved. The following case report describes the surgical management of a subdural hematoma in a hemophiliac patient using the most widely available Factor viii concentrate, cryoprecipitate, ~a to correct the clotting defect. The successful outcome of this case testifies that intracranial surgery may be safely performed in the hemophiliac patient.
Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population (2016)

MEF2-regulated pathways were identified as potential candidate pathways in the etiology of DLD. Several genes (including the candidate SETBP1 and other MEF2-related genes) seem to jointly influence certain, but not all, facets of the DLD phenotype. Even when genetic and environmental diversity is reduced, DLD is best conceptualized as etiologically complex. Future research should establish whether the signals detected in the AZ population can be replicated in other samples and languages and provide further characterization of the identified pathway.
Analytical and numerical results for feedback based flow control of B-ISDN/ATM networks with significant propagation delays (2002)

We consider a system comprising of a single bottleneck node fed by multiple Markov modulated fluid sources each of which is policed by a corresponding access regulator that marks all excess traffic as well as drops some of the excess traffic. The amount of excess traffic released is varied dynamically based on delayed feedback from the bottleneck. We present analytical and numerical results for this model that allow us to study the role of delayed feedback vis-a-vis certain time constants and traffic parameters associated with the system. In particular we show that even for a large propagation delay such as that required for the length of the continental USA the feedback policy is more effective, though the relative improvement of the feedback policy decreases as the delay increases. We also find that the feedback policy is most effective when the sources are moderately bursty.
Rotary MEMS comb-drive actuator with large deflection for photonic applications (2012)

Rotary comb-drive electrostatic actuators with smooth vertical sidewalls were designed and fabricated for photonic applications. Silicon on insulator (SOI) wafers with device layer thicknesses of up to 100 μm and oxide layers of 1-2 μm were used. Structures were fabricated through bulk micromachining of the handle layer followed by removal of the buried oxide. Deep reactive ion etching (DRIE) of the device layer defined the comb structure with simultaneous release of the moving arm. Thick photoresist and oxide masking layers were used for the high aspect ratio deep etches. Notching effects or depth variations of device layers were not observed. Etch/ passivation cycles in DRIE were optimized to obtain smooth sidewalls. Traces of etch scallops were confined only to the first few microns of the top and bottom edges of the reflecting sidewall. A movable arm length of 2 mm with a maximum rotation of 2.8 degrees was achieved. The edge deflection was over 100 μm at 100 volts. The fabricated structure provides a long reflecting sidewall that is accessible for hybrid integration in three dimensional space. The fabricated structures can be reliably operated in the kilohertz range.
Analyses of the Population Structure in a Global Collection of <i>Phytophthora nicotianae</i> Isolates Inferred from Mitochondrial and Nuclear DNA Sequences (2013)

Genetic variation within the heterothallic cosmopolitan plant pathogen Phytophthora nicotianae was determined in 96 isolates from a wide range of hosts and geographic locations by characterizing four mitochondrial (10% of the genome) and three nuclear loci. In all, 52 single-nucleotide polymorphisms (SNPs) (an average of 1 every 58 bp) and 313 sites with gaps representing 5,450 bases enabled the identification of 50 different multilocus mitochondrial haplotypes. Similarly, 24 SNPs (an average of 1 every 69 bp), with heterozygosity observed at each locus, were observed in three nuclear regions (hyp, scp, and β-tub) differentiating 40 multilocus nuclear genotypes. Both mitochondrial and nuclear markers revealed a high level of dispersal of isolates and an inconsistent geographic structuring of populations. However, a specific association was observed for host of origin and genetic grouping with both nuclear and mitochondrial sequences. In particular, the majority of citrus isolates from Italy, California, Florida, Syria, Albania, and the Philippines clustered in the same mitochondrial group and shared at least one nuclear allele. A similar association was also observed for isolates recovered from Nicotiana and Solanum spp. The present study suggests an important role of nursery populations in increasing genetic recombination within the species and the existence of extensive phenomena of migration of isolates that have been likely spread worldwide with infected plant material.
Toward Patient-Specific, Biologically Optimized Radiation Therapy Plans for the Treatment of Glioblastoma (2013)

Patient-individualized simulations using the combination of a biomathematical model with an optimization algorithm for radiation therapy generated biologically-guided doses that decreased normal tissue EUD and increased therapeutic ratio with the potential to improve survival outcomes for treatment of glioblastoma.
Optical activity of ferroelectric Cu<sub>3</sub>B<sub>7</sub>0<sub>13</sub>Cl (1984)

Abstract The temperature dependences of the optical susceptibilities, birefringence and optical activity, of Cu3B7O13Cl were measured in its paraelectric 43m-Td and ferroelectric mm2-C 2p modifications. In the ferroelectric phase the crystal becomes optically active, e.g., g 12 = (1.87 ± 0.03) ± 10−s at 24°C. The temperature dependence of the optical activity in the mm2-C 2v phase manifests a peak at the Curie point. This is a new optical effect which has never been found in any ferroelectrics. A remark is made on this phenomenon.
Long-Term Single-Dose Efficacy of a Vesicular Stomatitis Virus-Based Andes Virus Vaccine in Syrian Hamsters (2014)

Andes virus (ANDV) is highly pathogenic in humans and is the primary etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in South America. Case-fatality rates are as high as 50% and there are no approved vaccines or specific therapies for infection. Our laboratory has recently developed a replication-competent recombinant vesicular stomatitis virus (VSV)-based vaccine that expressed the glycoproteins of Andes virus in place of the native VSV glycoprotein (G). This vaccine is highly efficacious in the Syrian hamster model of HCPS when given 28 days before challenge with ANDV, or when given around the time of challenge (peri-exposure), and even protects when administered post-exposure. Herein, we sought to test the durability of the immune response to a single dose of this vaccine in Syrian hamsters. This vaccine was efficacious in hamsters challenged intranasally with ANDV 6 months after vaccination (p = 0.025), but animals were not significantly protected following 1 year of vaccination (p = 0.090). The decrease in protection correlated with a reduction of measurable neutralizing antibody responses, and suggests that a more robust vaccination schedule might be required to provide long-term immunity.
A Carbon Dioxide Gas Sensor Probe Based on a Lithium Ionic Conductor (1990)

Abstract A carbon dioxide gas sensor probe was fabricated by applying a high lithium ionic conductor as a solid electrolyte and a calcium carbonate + calcium oxide mixture as a solid reference electrode, and its ability for CO2 detection was examined. The electromotive force(EMF) obtained was in excellent agreement with the EMF value calculated from the Nernst’s equation for CO2 gas concentrations from 80 ppm(v/v) to 1 %(v/v).
Exhaustive Methylation of Some Ethylenediamine-Type Bases (1950)

Hoffmann's exhaustive methylation was carried out on N-(β-dimethylaminoethyl)-α-pyridone (I), -α-quinnolone (II), -phthalimidine (III), -α-piperidone (IV), -α-pyrrolidone (V), phenylacetic acid-(β-dimethylaminoethylmethylamide) (VI), -(β-dimethylaminoethylamide) (VII) and benzoie acid-(β-dimethylaminoethylamide) (VIII). It was found that compounds in which the H-atom attached to C-atom in β-position is easily liberated as a proton undergo olefin decomposition to give N-vinyl compounds, as in (I) and (II) where N-vinyl-α-pyridone and -α-quinolone, respectively, are formed. Other compounds such as (IV), (V) and (VI) undergo alcoholic decomposition. (III) is an intermediate of these two, while (VII) and (VIII) give some products which are assumed to be due to N-vinyl compound formed by olefin decomposition. The ease or difficulty in liberation of H at β-C as a proton depends on the effect of the lactam ring or acid amide radical, becoming easier as these tend to negative effect. The author has made some explanations of these decomposition reactions from electronic theory.
The Structure of Benzilide (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of BenzilideHarry H. Wasserman and Howard E. ZimmermanCite this: J. Am. Chem. Soc. 1950, 72, 12, 5787Publication Date (Print):December 1, 1950Publication History Published online1 May 2002Published inissue 1 December 1950https://pubs.acs.org/doi/10.1021/ja01168a544https://doi.org/10.1021/ja01168a544research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Passively aligned hybrid integration of 8 x 1 micromachined micro-Fresnel lens arrays and 8 x 1 vertical-cavity surface-emitting laser arrays for free-space optical interconnect (1995)

Surface micromachining technique has been successfully applied to the fabrications of a three-dimensional 8/spl times/1 micro-Fresnel lens array and other novel three-dimensional alignment structures. With the help of these three-dimensional structures, self-aligned integration of the micro-Fresnel lens array and an 8/spl times/1 vertical-cavity surface-emitting laser (VCSEL) array is realized for the first time with passive alignment. Individual addressing of the VCSEL/micro-lens element is also successfully demonstrated. With their three-dimensional and array structural characteristics, they are very attractive for free-space optical interconnect and other integrated micro-optical systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Active Retrotransposons Are a Common Feature of Grass Genomes (2001)

A large fraction of the genomes of grasses, members of the family Graminae, is composed of retrotransposons. These elements resemble animal retroviruses in their structure and possess a life cycle similar to theirs that includes transcription, translation, and integration of daughter copies. We have investigated if retrotransposons are generally transcribed in the grasses and other plants, and whether the various families of elements are translationally and integrationally active in multiple grass species. A systematic search of 7.8 x 10(5) publicly available expressed sequence tags from plants revealed widespread retrotransposon transcripts at a frequency of one in 1,000. Monocot retrotransposons found relatively more expressed sequence tags from non-source species than did those of dicots. Antibodies were raised to the capsid protein, GAG, of BARE-1, a transcribed and translated copia-like retrotransposon of barley (Hordeum vulgare). These detected immunoreactive proteins of sizes identical to those of the BARE-1 GAG and polyprotein, respectively, in other species of the tribe Triticeae as well as in oats (Avena sativa) and rice (Oryza sativa). Retrotransposon-based markers showed integrational polymorphisms for BARE-1 in different subfamilies of the Graminae. The results suggest that grasses share families of transcriptionally, translationally, and integrationally active retrotransposons, enabling a comparative and integrative approach to understanding the life cycle of retrotransposons and their impact on the genome.
Anhydrobiosis: An Unsolved Problem (1971)

The reversible cessation of metabolism and growth is a unique biological state. There are two types of organisms which are normally capable of of entering this state (cryptobiosis): (1) propagules of certain organisms and (2) certain rotifers, tardigrades, and nematodes. The latter group of organisms offer a unique opportunity to study the discontinuity of life processes, uncomplicated by simultaneous developmental processes and complex endogenous factors such as those responsible for the maintenance of dormancy. Working hypotheses and lines of research are pointed out in the areas of (1) metabolism during anhydrobiosis, (2) biochemical adaptations to desiccation, (3) morphological adaptations to desiccation.
T cell regulation of immunoglobulin class expression in the B cell response to TNP-Ficoll: characterization of the T cell responsible for preferential enhancement of the IgG2a response. (1984)

Syngeneic T cells injected into athymic nu/nu mice cause a preferential enhancement in the amount of IgG2a anti-TNP Ab produced by these mice to TNP-Ficoll. This enhancement appears to be caused by T cell effects on the IgG switching pathway. Through the use of F1----parent chimeras, the helper T cells were shown to affect TNP-Ficoll-responsive B cells in an H-2-unrestricted manner. The ability of T cells to mediate this IgG2a enhancement did not appear to be unique to any particular murine genetic background, because it was observed with T cells and nu/nu mice of C57BL/10, BALB/c, CBA/Ca, and B10.D2 strains. Priming of T cell donors with Ficoll or TNP-Ficoll did not increase the ability of splenic T cells, on a per cell basis, to enhance the IgG2a Ab response to TNP-Ficoll. The T cell population responsible for modulating the isotypic response was found to be sensitive to C-mediated cytotoxicity with both anti-Lyt-2 and anti-Lyt-1 hybridoma Ab. Although T cells from both the thymus and the spleen expressed enhancing activity, splenic T cells were more effective, on a per cell basis, than were thymocytes. The observations suggest that T cells that appear to enhance the switch to IgG2a in TNP-Ficoll-responsive B cells are not effectively primed by the antigen and interact with TNP-Ficoll-activated B cells through an H-2-unrestricted mechanism.
Pitfalls or Promise in Prostate Cancer Immunotherapy—Which Is Winning? (2008)

Strategies to enhance immunogenicity of vaccines and reassess how to effectively establish interpretable immunologic end points are under development and appear to be successful in affecting how these trials go forward.
Comparison of 2 Methods of Adjustment of Maximum Urinary Flow Rates (1988)

No AccessJournal of Urology1 Aug 1988Comparison of 2 Methods of Adjustment of Maximum Urinary Flow Rates Terry N. Layton, and George W. Drach Terry N. LaytonTerry N. Layton More articles by this author , and George W. DrachGeorge W. Drach More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)41639-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Comparison of 2 Methods of Adjustment of Maximum Urinary Flow Rates." The Journal of Urology, 140(2), p. 388 © 1988 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 140Issue 2August 1988Page: 388 Advertisement Copyright & Permissions© 1988 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Terry N. Layton More articles by this author George W. Drach More articles by this author Expand All Advertisement PDF DownloadLoading ...
A systematic review and meta-analysis on delaying surgery for urothelial carcinoma of bladder and upper tract urothelial carcinoma: Implications for the COVID19 pandemic and beyond (2022)

A delay from diagnosis of UCB or UTUC to definitive RC or RNU was associated with poorer survival outcomes. This was not the case for patients who received neoadjuvant chemotherapy.
Optique non-linéaire femtoseconde (1990)

Cet article prsente le principe de fonctionnement et la ralisation pratique d'un laser femt oseconde ainsi que quelques application s.
MIMO : from theory to implementation (2010)

Foreword from Arogyaswami Paulraj, Professor (Emeritus), Stanford University (USA) * The first book to show how MIMO principles can be implemented in today's mobile broadband networks and components * Explains and solves some of the practical difficulties that arise in designing and implementing MIMO systems. * Both theory and implementation sections are written in the context of the most recent standards: IEEE 802.11n (WiFi); IEEE 802.16 (WIMAX); 4G networks (3GPP/3GPP2, LTE).
Cell lines of human oral squamous‐cell carcinomas retaining their differentiated phenotype (1990)

Two cell lines from head-and-neck squamous-cell carcinomas (SCC) have been established and characterized. Cell line R105 was derived from a xenografted SCC of the floor of the mouth and cell line T87/rc from a SCC of the epiglottis. Identification of individual cytokeratins 4, 5, 7, 8, 10, 13, 14, 18 and 19 led to the conclusion that both cell types had squamous characteristics and that keratinization occurred in xenografts. Ultrastructurally, junctional complexes were observed in both cell lines. Characteristic marker chromosomes were found and although both cell lines were derived from male patients, the Y chromosome was missing from all examined cells. The basic biological parameters of both cell lines were modal chromosome numbers of 59 (R105) and 60 (T87/rc), a doubling time of 60 (R105) and 45 hr (T87/rc) and a DNA index of 1.54 (R105) and 1.31 (T87/rc). The tumorigenicity of the 2 cell lines was proved by the ability to form colonies on a plastic substratum, as well as in a soft agar assay. Furthermore, the cells could produce multi-cellular tumour spheroids, and formed tumour nodules after subcutaneous inoculation into nude mice. The R105 tumour cells appeared to be better differentiated than the T87/rc as observed by histology and immuno(histo)chemistry. Both cell lines appear to retain SCC differentiation after being xenografted into nude mice, cultured for more than 40 passages in vitro and thereafter again xenografted into nude mice.