gebhart/patrepeval huggingface dataset:
Different Features of Tumor-Associated NK Cells in Patients With Low-Grade or High-Grade Peritoneal Carcinomatosis (2019)

Peritoneal carcinomatosis (PC) is a rare disease defined as diffused implantation of neoplastic cells in the peritoneal cavity. This clinical picture occurs during the evolution of peritoneal tumors, and it is the main cause of morbidity and mortality of patients affected by these pathologies, though cytoreductive surgery with heated intra-peritoneal chemotherapy (CRS/HIPEC) is yielding promising results. In the present study, we evaluated whether the tumor microenvironment of low-grade and high-grade PC could affect the phenotypic and functional features and thus the anti-tumor potential of NK cells. We show that while in the peritoneal fluid (PF) of low-grade PC most CD56dim NK cells show a relatively immature phenotype (NKG2A+KIR-CD57-CD16dim), in the PF of high-grade PC NK cells are, in large majority, mature (CD56dimKIR+CD57+CD16bright). Furthermore, in low-grade PC, PF-NK cells are characterized by a sharp down-regulation of some activating receptors, primarily NKp30 and DNAM-1, while, in high-grade PC, PF-NK cells display a higher expression of the PD-1 inhibitory checkpoint. The compromised phenotype observed in low-grade PC patients corresponds to a functional impairment. On the other hand, in the high-grade PC patients PF-NK cells show much more important defects that only partially reflect the compromised phenotype detected. These data suggest that the PC microenvironment may contribute to tumor escape from immune surveillance by inducing different NK cell impaired features leading to altered anti-tumor activity. Notably, after CRS/HIPEC treatment, the altered NK cell phenotype of a patient with a low-grade disease and favorable prognosis was reverted to a normal one. Our present data offer a clue for the development of new immunotherapeutic strategies capable of restoring the NK-mediated anti-tumor responses in association with the CRS/HIPEC treatment to increase the effectiveness of the current therapy.
A High Power W-Band (90-99 GHz) Solid State Transmitter For High Duty Cycles And Wide Bandwidth (2005)

A high average power W-Band solid state transmitter using a 2-diode and a 4-diode IMPATT power combiner has achieved over 1.89 W and exceedingly versatile performance over a broad range of pulsewidths and duty cycles with a tunable bandwidth from 90 GHz to 99 GHz.
Camera-based vehicle localization at intersections using detailed digital maps (2010)

In recent years, a special research focus of the automotive industry was set on vehicle positioning. Though the accuracy of current simple positioning systems is sufficient for navigation devices, future technologies will be much more demanding. Examples for this future technologies are cooperative systems or enhanced map based assistance systems. All positioning system which will be elaborated always have to fulfill the requirements accuracy, reliability, and affordability. This time, there is a wide variety of approaches to reach the goal of higher accuracy without using expensive high-performance sensors. The algorithm presented in this paper utilizes image landmarks in combination with a low-cost Global Navigation Satellite System receiver, a detailed digital map, and vehicle odometry. In contrast to other approaches in the literature, which usually try to extract features from camera images and match those features with map information, the algorithm presented in this work moves this matching step from feature level to sensor data level. This means that map data is used to create an image of map features as the camera would sense it. The evaluation of this image prediction utilizes the coherency value, which is calculated from the structure tensor. By predicting a whole image, there is no more the need for a probabilistic description of extracted landmarks, i.e. it is also no decision about the existence of particular features necessary. Furthermore, any geometry including area landmarks can be used as landmarks. The paper describes a way to model area landmarks for efficient transformation to the predicted image. In the presented algorithm, the likelihood models used for the evaluation of the predicted coherency image are derived from real, manually labeled data. We show promising results of a test drive in an area with complex intersections. Those results are compared to ground truth data.
The Leo Sachs’ legacy: a pioneer’s journey through hematopoiesis (2017)

Leo Sachs spent almost his entire scientific career in Israel, at the Weizmann Institute of Science, and became a worldwide renowned scientist for his pioneering studies in normal hematopoiesis, its breakdown in leukemia and the suppression of malignancy by inducing differentiation, thereby bypassing genetic defects that give rise to malignancy. The cell culture system he established in the early 1960s for the clonal development of normal hematopoietic cells, made it possible to discover the proteins that regulate the viability, proliferation and differentiation of different blood cell lineages, the molecular basis of normal hematopoiesis and the changes that drive leukemia. His studies established significant general concepts including: a) the value of a multi-gene cytokine network in regulating the viability, number and development of different cell types; b) the existence of alternative pathways that give flexibility to development in both normal and cancer cells; c) the response of some cancer cells to normal regulators of development; d) suppression of myeloid leukemia by inducing differentiation, bypassing malignancy-driving genetic defects; e) identification of chromosomes that control tumor suppression; f) discovering apoptosis as a major mechanism by which WT-p53 suppresses malignancy and g) the ability of hematopoietic cytokines to suppress apoptosis in both normal and leukemic cells. It is gratifying that Leo had the good fortune to witness his pioneering discoveries and ideas move from the basic science stage to effective clinical applications, augmenting normal hematopoiesis in patients with various hematopoietic deficiencies, in patients requiring hematopoietic stem cell transplantation and in the suppression of malignancy by inducing differentiation and apoptosis.
Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol (1992)

Human leukocyte elastase (HLE) is a serine protease which has been implicated as a causative agent in several pulmonary diseases. The continued modification of our previously reported cephalosporin-based HLE inhibitors has led to the identification of a series of C-2 amides with potent, topical activity in an in vivo hamster lung hemorrhage model. While the most potent in vitro HLE inhibition had previously been obtained with lipophilic ester derivatives, it was found that the less active, but more polar and stable, amide derivatives were much more effective in vivo. The development of the structure--activity relations for optimization of these activities is discussed. These results led to the selection of 3-(acetoxymethyl)-2-[(2(S)-carboxypyrrolidino)carbonyl]-7 alpha-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene, 5,5-dioxide (3, L-658,758) as a selective, potent, time-dependent HLE inhibitor suitable for formulation as a topical aerosol drug for possible clinical use.
Regulation of extracellular slime production by Actinomyces viscosus (1981)

Extracellular slime polysaccharides produced two Actinomyces viscosus strains, T14V and T14AV, were compared. In various media containing glucose, T14Av produced abundant extracellular viscous slime polysaccharide, whereas T14V produced lower levels. Furthermore, fractionation of these polysaccharides showed that the two extracellular polysaccharides differed in molecular size and net charge. Since there was a significant difference in the relative abilities of chemically defined medium and chemically defined tissue culture medium to support slime production by T14Av, the nutritional factors influencing the production of extracellular slime were examined. Sodium bicarbonate was demonstrated to stimulate both cellular growth and the production of extracellular slime. In chemically defined medium with and without sodium bicarbonate, strain T14Av produced large quantities of viscous slime in glucose and sucrose media. In contrast, relatively low levels of slime were produced in fructose, lactose, raffinose, and inositol media, even though sodium bicarbonate stimulated the growth of T14Av in these latter media.
VINCA ALKALOIDS. III.<sup>1</sup> CHARACTERIZATION OF LEUROSINE AND VINCALEUKOBLASTINE, NEW ALKALOIDS FROM VINCA ROSEA LINN. (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVINCA ALKALOIDS. III.1 CHARACTERIZATION OF LEUROSINE AND VINCALEUKOBLASTINE, NEW ALKALOIDS FROM VINCA ROSEA LINN.N. Neuss, M. Gorman, G. H. Svoboda, G. Maciak, and C. T. BeerCite this: J. Am. Chem. Soc. 1959, 81, 17, 4754–4755Publication Date (Print):September 1, 1959Publication History Published online1 May 2002Published inissue 1 September 1959https://pubs.acs.org/doi/10.1021/ja01526a086https://doi.org/10.1021/ja01526a086research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Frequency-based features for early cerebral palsy prediction (2015)

In this paper we aim at predicting cerebral palsy, the most serious and lifelong motor function disorder in children, at an early age by analysing infants' motion data. An essential step for doing so is to extract informative features with high class separability. We propose a set of features derived from frequency analysis of the motion data. Then, we evaluate the practicality of our features on one of the richest data sets collected to study this disease. In this data set, the motion data are extracted from both electromagnetic sensors as well as video camera. The proposed features are used for classifying both data sets. Using these features, we manage to achieve promising classification performance. Classification accuracy of 91% for the sensor data and 88% for the video-derived data show not only the advantage of employing these features for predicting cerebral palsy, but also that replacing electromagnetic sensors with a video camera is feasible.
A microfiber cavity with minimal-volume confinement (2011)

We demonstrate a type of microcavity with minimal-volume confinement using a high-contrast phase-shifted Bragg grating in a microfiber. While waveguiding by the air-silica boundary provides a diffraction-limited two-dimensional confinement, the grating introduces the third degree of confinement. Theoretical simulations verified the microfiber cavity confinement while the experimental demonstration, carried out in samples nanostructured by focused ion beam, showed a good agreement with theoretical predictions. This cavity can be used for a variety of applications ranging from sensing to quantum dynamic experiments.
Controlling Personality-Based Stylistic Variation with Neural Natural\n Language Generators (2018)

Natural language generators for task-oriented dialogue must effectively\nrealize system dialogue actions and their associated semantics. In many\napplications, it is also desirable for generators to control the style of an\nutterance. To date, work on task-oriented neural generation has primarily\nfocused on semantic fidelity rather than achieving stylistic goals, while work\non style has been done in contexts where it is difficult to measure content\npreservation. Here we present three different sequence-to-sequence models and\ncarefully test how well they disentangle content and style. We use a\nstatistical generator, Personage, to synthesize a new corpus of over 88,000\nrestaurant domain utterances whose style varies according to models of\npersonality, giving us total control over both the semantic content and the\nstylistic variation in the training data. We then vary the amount of explicit\nstylistic supervision given to the three models. We show that our most explicit\nmodel can simultaneously achieve high fidelity to both semantic and stylistic\ngoals: this model adds a context vector of 36 stylistic parameters as input to\nthe hidden state of the encoder at each time step, showing the benefits of\nexplicit stylistic supervision, even when the amount of training data is large.\n
Hiring, Churn and the Business Cycle (2012)

Churn, defined as replacing departing workers with new ones as workers move to more productive uses, is an important feature of labor dynamics. The majority of hiring and separation reflects churn rather than hiring for expansion or separation for contraction. Using the JOLTS data, we show that churn decreased significantly during the most recent recession with almost four-fifths of the decline in hiring reflecting decreases in churn. Reductions in churn have costs because they reflect a reduction in labor movement to higher valued uses. We estimate the cost of reduced churn to be $208 billion. On an annual basis, this amounts to about .4% of GDP for a period of 3 1/2 years.
ChemInform Abstract: ENEHYDRAZINES. 16. STABLE BORANES FROM ENEHYDRAZONES (1977)

Abstract Die Hydroborierung der aus Acetessigester und den entsprechenden Benzaldehydmethylhydrazonen nach bekannter Methode synthetisierten Enhydrazone (I) ergeben mit Diboran in Diglyme oder THF in guten Ausbeuten die stabilen, kristallisierten Borane (II).
Détection de Mycoplasma hyopneumoniae par PCR dans les conditions de la pratique (1998)

National audience
Impact of Cotransplantation of Mesenchymal Stem Cells on Lung Function After Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Following Non-Myeloablative Conditioning (2014)

MSC co-infusion does not induce pulmonary deterioration 1 year after HSCT with NMA conditioning. MSC appear to be safe for the lung, but close monitoring of pulmonary infections remains essential.
Motion planner and lateral-longitudinal controllers for autonomous maneuvers of a farm vehicle in headland (2009)

This paper addresses the problem of path generation and motion control for the autonomous maneuvers of a farm vehicle in headland. A reverse turn planner is firstly investigated, based on primitives connected together to easily generate the reference motion. Then, both steering and speed control algorithms are presented to accurately guide the vehicle. They are based on a kinematic model extended with additional sliding parameters and on model predictive control approaches. Real world experiments have been carried out on a low adherent terrain with an experimental mobile robot. At the end of each row, the reverse turn is automatically generated to connect the next reference track, and the maneuver is autonomously performed by the vehicle. Reported experiments demonstrate the capabilities of the proposed algorithms.
Identification and characterization of an alternative oxidase in the entomopathogenic fungus<i>Metarhizium anisopliae</i> (2008)

Mitochondria of Metarhizium anisopliae contain an alternative oxidase (AOX), which reduces oxygen to water by accepting electrons directly from ubiquinol. AOX activity is demonstrated in situ as a constitutive enzyme. Greatest activity of AOX appears at the beginning and at the end of the fungal developmental cycle, germination of aerial conidia and the formation of submerged conidia, respectively. Changes in nutritional conditions, e.g., the presence of host insect cuticle or nutrient starvation had no effect on the induction of AOX activity. Antimycin A, an electron transport chain inhibitor, induced AOX activity. Cloning of the AOX DNA and the alignment of the deduced amino acid sequence of a segment of the AOX gene from M. anisopliae shows structural similarities with other AOX sequences with differing levels of variation when compared with homologous sequences from plants, yeasts, and filamentous fungi. Alternative oxidase in entomopathogenic fungi may have a positive contribution to ecological fitness.
Synthesized Tuning Comes to Black and White TV (1982)

During the last ten years, keyboard tuning has become such an important component of color television that it no longer deserves the slightly pejorative description of "feature" but has been accepted as the normal tuning means for any except the lowest cost receivers. Black and white receivers have more serious cost limitations than even the lowest cost color set and therefore it is not surprising that keyboard tuning has not been inrcorporated in these sets. The cost of keyboard tuning has been rapidly diminishing while the cost of mechanical tuners has been steady or increasing. With this background in mind it was decided to design a keyboard tuning system specifically for black and white television that would be both cost effective and would provide adequate performance with the monopole antenna typically used with these sets.
Web page segmentation with structured prediction and its application in web page classification (2014)

We propose a framework which can perform Web page segmentation with a structured prediction approach. It formulates the segmentation task as a structured labeling problem on a transformed Web page segmentation graph (WPS-graph). WPS-graph models the candidate segmentation boundaries of a page and the dependency relation among the adjacent segmentation boundaries. Each labeling scheme on the WPS-graph corresponds to a possible segmentation of the page. The task of finding the optimal labeling of the WPS-graph is transformed into a binary Integer Linear Programming problem, which considers the entire WPS-graph as a whole to conduct structured prediction. A learning algorithm based on the structured output Support Vector Machine framework is developed to determine the feature weights, which is capable to consider the inter-dependency among candidate segmentation boundaries. Furthermore, we investigate its efficacy in supporting the development of automatic Web page classification.
[Isolated orchidodynia as the initial symptom of aneurysm of the abdominal aorta]. (2007)

A 67-year-old man presented with isolated pain of the right testicle. He was admitted and treated for epididymitis. His symptoms did not improve and lower abdominal pain developed. After hypotension and severe anaemia (Hb 2.1 mmol/l) had developed, abdominal echography was carried out, revealing a ruptured abdominal aortic aneurysm. The patient underwent surgical repair with an aortic-bifemoral prosthesis and was ultimately discharged without further complications. This is the fourth report in the literature of orchidodynia as referred pain from an aneurysm of the abdominal aorta.
UNED Online Reputation Monitoring Team at RepLab 2013 (2013)

This paper describes the UNED's Online Reputation Moni- toring Team participation at RepLab 2013 (3). Several approaches were tested: rst, an instance-based learning approach that uses Heterogene- ity Based Ranking to combine seven dierent similarity measures was applied for all the subtasks. The ltering subtask was also tackled by au- tomatically discovering lter keywords: those whose presence in a tweet reliably conrm (positive keywords) or discard (negative keywords) that
<b>Glutaminyl‐tRNA synthetase: from genetics to molecular recognition</b> (1996)

Accurately aminoacylated tRNAs are an a priori requirement for translation of the genetic code. They are synthesized by the aminoacyl-tRNA synthetases which select both the correct amino acid and tRNA from a total of more than 400 possible combinations. Genetic, biochemical and structural studies have begun to reveal the mechanisms by which this specificity is achieved by Escherichia coli glutaminyl-tRNA synthetase (GlnRS). Sequence-specific interactions between GlnRS and tRNA(Gln) determine both the accuracy of tRNA selection and the efficiency of aminoacylation. Thus, amino acid recognition is tRNA-dependent. Consequently, while a noncognate tRNA may be recognized by GlnRS, the resulting tRNA-enzyme complex displays a considerably reduced affinity for glutamine compared to wild-type. This mechanism now provides a ready explanation as to why the majority of tRNA mischarging events, including those originally described over 25 years ago for GlnRS, impair cellular viability only to a limited degree.
Recommendations for the Diagnosis and Management of Turner Syndrome<sup>1</sup> (2001)

Comprehensive recommendations on the diagnosis of Turner syndrome (TS) and the care of affected individuals were published in 1994. In the light of recent advances in diagnosis and treatment of TS, an international multidisciplinary workshop was convened in March 2000, in Naples, Italy, in conjunction with the Fifth International Symposium on Turner Syndrome to update these recommendations. The present paper details the outcome from this workshop. The genetics and diagnosis of the syndrome are described, and practical treatment guidelines are presented.
Preparation of Au-BiVO<sub>4</sub> Heterogeneous Nanostructures as Highly Efficient Visible-Light Photocatalysts (2011)

Au-BiVO(4) heterogeneous nanostructures have been successfully prepared through in situ growth of gold nanoparticles on BiVO(4) microtubes and nanosheets via a cysteine-linking strategy. The experimental results reveal that these Au-BiVO(4) heterogeneous nanostructures exhibit much higher visible-light photocatalytic activities than the individual BiVO(4) microtubes and nanosheets for both dye degradation and water oxidation. The enhanced photocatalytic efficiencies are attributed to the charge transfer from BiVO(4) to the attached gold nanoparticles as well as their surface plasmon resonance (SPR) absorption. These new heteronanostructures are expected to show considerable potential applications in solar-driven wastewater treatment and water splitting.
SUPERSONIC FLUIDIC OSCILLATOR (1989)

Intending to develop a plane bending fatigue testing machine of a cantilever having a long life without maintenance, a fluidic oscillator using supersonic bistable device has been designed and tested. This machine which a new type fluidic oscillator is applied into has some advantages. That is, it can deflect a test piece with jet stream, it can be used in high frequency range of testing vibration, and it has no mechanical vibration of machine itself. Therefore it is of use for impact plane bending fatigue test of a test piece fi xed as a cantilever.The new type fluidic oscillator is a kind of the loaded oscillator with the bifurcated channels of each outlet. A tank or tube as a capacitance is connected with one of the bifurcated channels, and the other of them constructs one of two opposite nozzles. A fatigue test piece is set between these opposite nozzles forming flapper-nozzle confi guration and is vibrated by the alternately impinging jets.The supersonic fluidic oscillator with some special features mentioned above has been designed and tested. And the oscillation mechanism has been explained by a simple analytical model.