gebhart/patrepeval huggingface dataset:
SCHOOL PHOBIA (1973)

The results of a double blind, placebo-controlled study of the effects of imipramine among 35 school phobic children between the ages of 6 to 14 are reported. The children and families were given a multidiscipline treatment program concurrently with imipramine or placebo treatment. Imipramine, over a 6-week period, was found to be significantly superior to placebo in inducing school return and in global therapeutic efficacy. Doses of medication ranged from 100 to 200 mg/day after 6 weeks of treatment. It was found that imipramine effects could not be detected after 3 weeks of therapy but were clearly present after 6 weeks. Of 10 items rated by the psychiatrists at baseline and after 6 weeks of treatment, 4 items which reflect the severity of the child's phobic behavior, the child's venturesomeness from the mother, physical symptoms while going to school, and fear of going to school were significantly improved by imipramine treatment. Among 10 items rated by mothers, only 1 item reflecting depressive mood showed a significant drug effect. On the whole, side effects were not significant, and only one child required dosage alteration due to orthostatic hypotension. The diagnostic characteristics of this population are discussed. Further, the relevance of the findings to theories of school phobia is examined.
Implementation of Unified Power Flow Controller and Verification for Transmission Capability Improvement (1998)

This paper describes a control method and system configuration of UPFC(Unified Power Flow Controller). UPFC is one of the promising power electronics equipments because it is an extremely flexible power controller capable of controlling all of the transmission line valiables(voltage, impedance and voltage phase angle). Due to the control flexibility, however, it is important to select a proper contol scheme corresponding to the purpose.Under the reserch project for the reinforcement technology of electric power interconnection, a miniature model of UPFC for the real time analog simulator was developed. Series side of UPFC has three control modes (perpendicular voltage control, impedance control and voltage angle control). It is used for power flow control and/or power system stabilizing control. Shunt side is used for voltage control or reactive power control in addition to compensating the power required from series side. Various tests were performed to compare control modes and the perpendicular voltage control is proposed as the simplest and most practical method because the capacity of the shunt compensator is minimized and power flow control sensitivity is maintained over a wide range of angle.
On adaptively trained neural networks (2005)

In this paper a new procedure to adaptively adjust weights in a layered neural network is proposed. Nonlinear programming techniques are used in order to properly calculate the new weight set. This methodology can be used for time varying models with no necessity of retraining One of the main features of our approach concerns the designer flexibility to control a trade off problem between fitting new incoming data and causing minimum damage to the information related to the original data set. We analyze the solution existence.
SURFACE MARKERS ON HUMAN B AND T LYMPHOCYTES (1973)

Human peripheral lymphocytes were investigated for receptors binding Epstein-Barr virus (EBV) because of the regular association of this virus with infectious mononucleosis and Burkitt's lymphoma. This was done by a cytoadherence technique where virus-producing cells, displaying fresh viral determinants in their cytoplasmatic membrane, were mixed with lymphocytes. Unfractionated lymphocytes were found to adhere to these cells in contrast to column-purified T lymphocytes. The specificity of the binding was confirmed by blocking experiments that showed that sera containing high titers of antibodies directed against the virus could partially inhibit the adherence in contrast to low-titer sera. It is concluded that B lymphocytes, in contrast to T lymphocytes, have receptors for EBV. In a second line of experiments it was found that established human lymphoblastoid lines that carry the EBV genome had receptors characteristic for B lymphocytes and did not form T-lymphocyte rosettes. In contrast, a line of known T-lymphocyte origin that did not carry the EBV genome had receptors characteristic for T lymphocytes. EBV-transformed simian lymphoblastoid lines had surface markers indicating a B-lymphocyte origin in contrast to HVS-transformed simian lines that lacked surface immunoglobulin but carried receptors for sheep red blood cells.
[Specificity of the radioimmunoassay for low molecular weight human kininogen]. (1980)

The authors have studied the crossing immunoreactivity of various antigens in the radioimmunoassay of Low Molecular Weight Kininogen: serum and plasma proteins, human albumin, Bradykinin, High Molecular Weight Kininogen and the products of enzymatic degradation of Low Molecular Weight Kininogen.
Integration of ileum cannulated pigs andin vitro fermentation to quantify the effect of diet composition on the amount of short-chain fatty acids available from fermentation in the large intestine (1999)

Using cannulated pigs and a standardised in vitro fermentation system the effect of diet and non-starch polysaccharides (NSP) on the amount of energy available from microbial fermentation in the large intestine could be predicted. The available energy was calculated from the amounts of short-chain fatty acids (SCFA) produced. Three diets were investigated: a low fibre diet based essentially on wheat flour (56 g NSP kg−1 feed) and two high fibre diets with added oat bran (93 g NSP kg−1 feed) or wheat bran (102 g NSP kg−1 feed). Colonic fermentation was estimated by in vitro fermentation of freeze-dried ileal effluent collected from cannulated pigs. The in vitro fermentation method was optimised to use 10 g ileum content litre−1 incubated at pH 6.0 in a fermentor containing faecal slurry consisting of anaerobic mineral salts medium and 50 g litre −1 faeces from pigs fed the same diets as the cannulated pigs. The results demonstrate that it is very important to compensate for the faecal SCFA contribution when calculating the amount of SCFA produced from ileal digesta during in vitro fermentation. The amount of NSP digested in vitro was compared with data obtained from in vivo studies and there was a good agreement between in vivo and in vitro data. We concluded that the integrated in vivo–in vitro method is a valuable technique to estimate the effect of diet and NSP on the amount of SCFA produced in the large intestine and when fed the three diets the microbial fermentation in the large intestine provided between 2.4–6.4% of the total available energy. © 1999 Society of Chemical Industry
Connaissance du Contexte, Confidentialité et Accès Mobiles : une Approche Web Sémantique et Multi-agents (2004)

National audience
<i>C</i>-Linked Antifreeze Glycoprotein (<i>C</i>-AFGP) Analogues as Novel Cryoprotectants (2011)

Significant cell damage occurs during cryopreservation resulting in a decreased number of viable and functional cells post-thawing. Recent studies have correlated the unsuccessful outcome of regenerative therapies with poor cell viability after cryopreservation. Cell damage from ice recrystallization during freeze-thawing is one cause of decreased viability after cryopreservation. We have assessed the ability of two C-AFGPs that are potent inhibitors of ice recrystallization to increase cell viability after cryopreservation. Our results indicate that a 1-1.5 mg/mL (0.5-0.8 mM) solution of C-AFGP 1 is an excellent alternative to a 2.5% DMSO solution for the cryopreservation of human embryonic liver cells.
Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2 (2018)

Components of the Fanconi anemia and homologous recombination pathways play a vital role in protecting newly replicated DNA from uncontrolled nucleolytic degradation, safeguarding genome stability. Here we report that histone methylation by the lysine methyltransferase SETD1A is crucial for protecting stalled replication forks from deleterious resection. Depletion of SETD1A sensitizes cells to replication stress and leads to uncontrolled DNA2-dependent resection of damaged replication forks. The ability of SETD1A to prevent degradation of these structures is mediated by its ability to catalyze methylation on Lys4 of histone H3 (H3K4) at replication forks, which enhances FANCD2-dependent histone chaperone activity. Suppressing H3K4 methylation or expression of a chaperone-defective FANCD2 mutant leads to loss of RAD51 nucleofilament stability and severe nucleolytic degradation of replication forks. Our work identifies epigenetic modification and histone mobility as critical regulatory mechanisms in maintaining genome stability by restraining nucleases from irreparably damaging stalled replication forks.
Ankstyvojo brendiminio amžiaus moksleivių griaučių raumenų funkcinės būklės įvertinimas (2005)

Medicinos Akademija (MA)
From the shards of a shattered genome, diversity (2008)

Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms giving ...Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In ...
THE PRESENCE OF POSTTRANSPLANT HLA-SPECIFIC IgG ANTIBODIES DETECTED BY ENZYME-LINKED IMMUNOSORBENT ASSAY CORRELATES WITH SPECIFIC REJECTION PATHOLOGIES (1997)

Posttransplant monitoring of anti-HLA antibodies with routine techniques gives unsatisfactory results due to a variety of technical limitations. We investigated how a new alternative technique correlates with posttransplant clinical events. A total of 313 nonselected serum samples from 136 patients were screened by an ELISA utilizing captured soluble HLA class I antigens. We observed the absence of anti-HLA antibody production in acute rejection cases responding to standard antirejection therapy. On the other hand, we showed a clear presence of these antibodies in acute rejection episodes not responding to standard therapy (P<0.0001) and in chronic rejection (P<0.001). We conclude that routine posttransplant monitoring by ELISA offers early risk assessment that is crucial for proper immunosuppression and for antirejection therapy choice.
Reaktionen von 1,5‐difluor‐2,4‐dinitrobenzol mit insulin 2. Mitt. Versuche mit insulin (1958)

Abstract Amorphes, zinkarmes Rinder‐Insulin wurde mit Difluordinitrobenzol unter verschiedenen Konzentrationsverhältnissen behandelt und die Reaktionsbedingungen für weitgehend intramolekularen Umsatz ermittelt. Bei der papierchromatographischen Untersuchung der Hydrolysate des behandelten Insulins konnten die Reaktionsprodukte mittels der in der ersten Mitteilung beschriebenen Modellsubstanzen identifiziert werden. Die Ergebnisse bestätigen auf neuem, unabhängigen Weg: Die kleinste Einheit des Insulins ist das Zweikettenmolekül mit dem Molekulargewicht (Rinder‐Insulin) M = 5733. Bei Aggregation lagern sich die Zweikettenmoleküle vermutlich mit ihren Aminoenden an einer Seite zusammen.
HGV&TB: a comprehensive online resource on human genes and genetic variants associated with tuberculosis (2014)

Tuberculosis (TB) is an infectious disease caused by fastidious pathogen Mycobacterium tuberculosis. TB has emerged as one of the major causes of mortality in the developing world. Role of host genetic factors that modulate disease susceptibility have not been studied widely. Recent studies have reported few genetic loci that provide impetus to this area of research. The availability of tools has enabled genome-wide scans for disease susceptibility loci associated with infectious diseases. Till now, information on human genetic variations and their associated genes that modulate TB susceptibility have not been systematically compiled. In this work, we have created a resource: HGV&TB, which hosts genetic variations reported to be associated with TB susceptibility in humans. It currently houses information on 307 variations in 98 genes. In total, 101 of these variations are exonic, whereas 78 fall in intronic regions. We also analysed the pathogenicity of the genetic variations, their phenotypic consequences and ethnic origin. Using various computational analyses, 30 variations of the 101 exonic variations were predicted to be pathogenic. The resource is freely available at http://genome.igib.res.in/hgvtb/index.html. Using integrative analysis, we have shown that the disease associated variants are selectively enriched in the immune signalling pathways which are crucial in the pathophysiology of TB. Database URL: http://genome.igib.res.in/hgvtb/index.html
Phenotypic and genetic diversity of enterococci isolated from Italian cheeses (2001)

In the present study, 124 enterococcal strains, isolated from traditional Italian cow, goat and buffalo cheeses, were characterized using phenotypic features and randomly amplified polymorphic DNA polymerase chain reaction (RAPD-PCR). The RAPD-PCR profiles obtained with four primers and five different amplification conditions were compared by numerical analysis and allowed an inter- and intraspecific differentiation of the isolates. Whole cell protein analysis by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) was used as a reference method for species identification. The strains were identified as Enterococcus faecalis (82 strains), E. faecium (27 strains), E. durans (nine strains), E. gallinarum (four strains) and E. hirae (two strains). Species recognition by means of RAPD-PCR was in agreement with the SDS-PAGE results except for eight strains of E. faecium that clustered in separated groups. On the other hand, phenotypic identification based on carbohydrate fermentation profiles, using the rapid ID 32 STREP galleries, gave different results from SDS-PAGE in 12.1% of the cases. The majority of the strains had weak acidifying and proteolytic activities in milk. One E. faecium strain showed vanA (vancomycin resistance) genotype while four strains showed a beta-haemolytic reaction on human blood. Several strains showed antagonistic activity towards indicator strains of Listeria innocua, Clostridium tyrobutyricam and Propionibacterium freudenreichii subsp. shermanii.
Study of the mechanism of higher alcohol synthesis on copper-zinc oxide-aluminum oxide catalysts by catalytic tests, probe molecules, and temperature programmed desorption studies (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudy of the mechanism of higher alcohol synthesis on copper-zinc oxide-aluminum oxide catalysts by catalytic tests, probe molecules, and temperature programmed desorption studiesA. Kiennemann, H. Idriss, R. Kieffer, P. Chaumette, and D. DurandCite this: Ind. Eng. Chem. Res. 1991, 30, 6, 1130–1138Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/ie00054a009https://doi.org/10.1021/ie00054a009research-articleACS PublicationsRequest reuse permissionsArticle Views697Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Techniques in Proving the Hardness of Approximation (2011)

For this penultimate chapter, we turn from techniques for designing good approximation algorithms to techniques for proving that problems are hard to approximate within certain factors. Our coverage of this topic will be relatively brief: indeed, another book could be written on this subject alone.
Antifatigue and Antistress Effect of the Hot-Water Fraction from Mycelia of Cordyceps sinensis (2003)

This study was conducted to investigate the chemical component of the hot water (HW) fraction of mycelia of Cordyceps sinensis and its antifatigue and antistress effect against a stimulus in vivo using rats and mice. The growth of mycelia reached a maximum level of 31.6 g/l after 120 h of incubation. The main chemical composition of the HW fraction of mycelia of C. sinensis was found to be carbohydrate (78.9%) with 5% moisture. The swimming endurance capacity of mice orally administered with the HW fraction (150 and 300 mg/kg/d, respectively) was significantly prolonged from 75 to 90 min with a lessening of fatigue. When the HW fraction (150 mg/kg/d) was given to rats for 8 d including a 48 h stress period, the weight changes of the adrenal gland, spleen, thymus, and thyroid, which is an index of stress, were suppressed. The HW fraction also significantly inhibited the increase in total cholesterol and the decrease in alkaline phosphatase levels as biochemical parameters of immobilization stress in rats.
Immunoglobulins and antibody formation in mice during the graft versus host reaction. (1965)

During the GVH reaction produced in adult (C57B1 ☿×CBA ♂) F(1) hybrid mice by injection of C57B1 cells a profound drop in serum immunoglobulin levels was observed. The fall in IgG and IgA values was not reversed by antigenic stimulation with BSA, but the IgM level rose somewhat after BSA though never to the level seen in immunized controls. The antibody response to BSA, as measured by passive haemagglutination, was grossly depressed in experimental animals. Animals undergoing the GVH reaction showed less local inflammatory response at the site of Freund's adjuvant injection than did controls. The possible importance of this immunoglobulin deficiency in the clinical presentation of the GVH syndrome is considered.
Probing of micromagnetic configuration in manganite channels by transport measurements (2007)

We explore the possibility of tracking magnetization orientation in artificial structures patterned in ${\mathrm{La}}_{0.7}{\mathrm{Sr}}_{0.3}\mathrm{Mn}{\mathrm{O}}_{3}$ epitaxial films by magnetotransport measurements, exploiting the anisotropic magnetoresistance effect. We perform resistance measurements as a function of temperature, magnetic field, and angle between the applied in-plane magnetic field and the channel or crystalline axes in micrometric channels of different widths. We analyze quantitatively our results and extract information about magnetization easy axes, crystalline anisotropy, domain wall resistance, anisotropic magnetoresistance, energy of magnetic domain pinning, and magnetic reversal mechanisms. For channel widths larger than a few micrometers, the magnetization direction at low field $(\ensuremath{\leqslant}200\phantom{\rule{0.3em}{0ex}}\mathrm{Oe})$ is determined by magnetocrystalline easy axes, whereas for channel widths of $\ensuremath{\sim}1\phantom{\rule{0.3em}{0ex}}\ensuremath{\mu}\mathrm{m}$ or smaller, the shape anisotropy forces the magnetization to align along the channel axis. This gives a precise indication on how artificial patterning can be used to force the magnetization direction in manganite based spintronic devices. Values of magnetocrystalline constant up to $8000\phantom{\rule{0.3em}{0ex}}\mathrm{J}∕{\mathrm{m}}^{3}$ and anisotropic magnetoresistance values between 0.1% and 0.6% are found. Our data also indicate that, in the low field $(\ensuremath{\leqslant}200\phantom{\rule{0.3em}{0ex}}\mathrm{Oe})$ hysteretic regime, magnetization reversal occurs by thermal activated hopping of domain walls, with a characteristic hopping distance of $4--5\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$.
Gaseous wear products from lubricated thin film disks (1993)

Degradation products of perfluoropolyether lubricants were observed during friction tests on thin film magnetic recording disks using a mass spectrometer. The friction tests were conducted in high vacuum using thin-film read/write heads as sliders. Fomblin Z-dol and Krytox 143AX were used as lubricants. The removal rates observed are significant compared to the lubricant film thickness used. The data suggest that the degradation reaction is activated by low-energy electrons produced at the tribological interface.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
LAMOTRIGINE (LTG) PHARMACOKINETICS DURING DELIVERY AND LACTATION. (1999)

Departments of Clinical Pharmacology1 and of Clinical Neuroscience2, Karolinska Institute at Karolinska Hospital, Stockholm, Sweden. (introduced by O Beck)
Magnetostructural coupling from competing magnetic and chemical bonding effects (2020)

The authors find that the magnetostructural coupling in MnAs arises from an orbital-specific competition between exchange energies and kinetic energies, which may give rise to an exotic paramagnetic state.
Zum Mechanismus der Blutkörperchensenkung (1963)

Die Injektion von 1 mg Lipopolysaccharid aus E. coli bewirkt bei Kaninchen außer einer beschleunigten Senkung der Erythrocyten und Konzentrations-Erhöhung von Fibrinogen auch eine Erhöhung der Normalkonzentration der Plasmaproteine Haptoglobin und Coeruloplasmin.
Design Methodology for Global Resonant -Tree Clock Distribution Networks (2007)

Design guidelines for resonant H-tree clock distribu- tion networks are presented in this paper. A distributed model of a two-level resonant H-tree structure is described, supporting the design of low power, skew, and jitter resonant H-tree clock distribution networks. Excellent agreement is shown between the proposed model and SpectraS simulations. A case study is pre- sented that demonstrates the design of a two-level resonant H-tree network, distributing a 5-GHz clock signal in a 0.18- m CMOS technology. This example exhibits an 84% decrease in power dissipation as compared to a standard H-tree clock distribution network. The design methodology enables tradeoffs among design variables to be examined, such as the operating frequency, the size of the on-chip inductors and capacitors, the output resistance of the driving buffer, and the interconnect width. A sensitivity analysis of resonant H-tree clock distribution networks is also pro- vided. The effect of the driving buffer output resistance, on-chip inductor and capacitor size, and signal and shielding transmission line width and spacing on the output voltage swing and power consumption is described.
An Efficient Definition of Transmissibility for a General Equipment Isolation System (1997)

Abstract A definition of transmissibility is introduced so that the efficiency of the isolation system is easily assessed. The system to be isolated may, in principle, be of any complexity: an elastic body isolated from an elastic foundation, a rigid body isolated from an elastic or rigid foundation, and so on. The isolators may be of any number and nature, their elastic centre located at any co-ordinates and their angular positions, with respect the isolated system, arbitrary. A numerical example consisting of an aircraft engine mounted with viscoelastic isolators is worked out.