gebhart/patrepeval huggingface dataset:
Temperature measurements from a horizontal heater test in G-Tunnel (1991)

A horizontal heater test was conducted in G-Tunnel, Nevada Test Site, to study the hydrothermal response of the rock mass due to a thermal loading. The results of the temperature measurements are reported here. The measured temperatures agree well with a scoping calculation that was performed using a model which investigates the transport of water, vapor, air, and heat in fractured porous media. Our results indicate that the temperature field might be affected by the initial moisture content of the rock, the fractures in the rock, the distance from the free surface of the alcove wall, and the temperature distribution on the heater surface. Higher initial moisture content, higher fracture density, and cooling from the alcove wall tend to decrease the measured temperature. The temperature on top of the horizontal heater can was about 30{degrees}C greater than at the bottom throughout most of the heating phase, causing the rock temperatures above the heater to be greater than those below. Along a radius from the center of the heater, the heating created a dry zone, followed by a boiling zone and condensation zone. Gravity drainage of the condensed water in the condensation zone had a strong effect on the boiling process in the test region. The temperatures below and to the side of the heater indicated a region receiving liquid drainage from an overlying region of condensation. We verified that a thermocouple in a thin-wall tubing measures the same temperature as one grouted in a borehole.
Polyhedral Boron Compounds as Potential Linkers for Attachment of Radiohalogens to Targeting Proteins and Peptides. A Review (2002)

Polyhedral boron clusters (PBC) are three-dimensional inorganic aromatic systems. Some of them can easily be halogenated, and the halogen-boron bond in such systems is very strong. We consider the use of PBC as linkers for attachment of radioactive halogen isotopes to tumor-targeting proteins and peptides. In this review the major preconditions for such applications, such as biological considerations, knowledge concerning coupling chemistry and radiolabeling of PBC, are described. A review with 90 references.
Phosphorus tribromide promoted allylic rearrangement of a tertiary vinyl carbinol. Stereochemistry of the reaction product and application to the synthesis of JH-25, a potent juvenile hormone mimic (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphorus tribromide promoted allylic rearrangement of a tertiary vinyl carbinol. Stereochemistry of the reaction product and application to the synthesis of JH-25, a potent juvenile hormone mimicJames H. BablerCite this: J. Org. Chem. 1976, 41, 7, 1262–1264Publication Date (Print):April 1, 1976Publication History Published online1 May 2002Published inissue 1 April 1976https://pubs.acs.org/doi/10.1021/jo00869a043https://doi.org/10.1021/jo00869a043research-articleACS PublicationsRequest reuse permissionsArticle Views169Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Developmental Expression of Myeloid Leukemia Inhibitory Factor Gene in Preimplantation Blastocysts and in Extraembryonic Tissue of Mouse Embryos (1990)

Murine leukemia inhibitory factor (LIF) protein is a growth factor which has the ability to maintain the developmental potential of pluripotent embryonic stem cells through a specific receptor. We have examined the expression pattern of the LIF gene from the preimplantation stage (3.5 days post coitum) to the midgestation stage (12.5 days post coitum) of the mouse embryo. LIF transcripts were detected at the preimplantation blastocyst stage, whereas no transcripts were detectable in embryonic stem cells. LIF gene transcription continued in the extraembryonic tissue of the 7.5-day and in the placenta of 9.5-, 10.5-, and 12.5-day post coitum embryos. No transcripts were detected in the embryo proper of the corresponding stages. Our results suggest that this growth factor is synthesized in the extraembryonic part of the embryo and acts on the embryonic tissues during early mouse development.
Proteolysis of Aβ Peptide from Alzheimer Disease Brain by Gelatinase A (1994)

It has been recently reported that the 72 kDa proteolytic enzyme gelatinase A/type IV collagenase/matrix metalloproteinase 2 (MMP2) hydrolyzed the Lys 16-Leu 17 peptide bond of a synthetic decapeptide (YEVHHQKLVFF) representing the soluble A beta sequence of amino acid residues 10-20. Our aim was to test if this enzyme could also degrade the insoluble 40-42 residues long A beta peptides purified from Alzheimer Disease brain. Our results indicate that MMP2 hydrolyzes A beta 1-40 and A beta 1-42 peptides at Lys 16-Leu 17, at Leu 34-Met 35, and Met 35-Val 36 peptide bonds. These results suggest that MMP2 has the ability of degrading A beta of AD in vitro. If this hydrolysis also occurs in the brain's extracellular matrix, the enzymatic action of gelatinase a could prevent the generation of amyloidogenic A beta 1-40(42).
Diagnostic Criteria for Major Depressive Disorder in Cancer Patients: A Review (2013)

There was no standard reference test and precise definition of alternative criteria in these studies. There are no recognized diagnostic criteria for depression in cancer patients despite an apparent need for such criteria.
Satellite and terrestrial diversity reception performance in tropical regions (2009)

A diversity reception scheme using satellite and terrestrial links is an effective technique to reduce the large fading margins in satellite communications operating under fading conditions. The increased demand for bandwidth has led to the employment of frequencies above 10 GHz, where the dominant fading mechanism is rain attenuation. Signal attenuation is aggravated in heavy rain climatic regions. As it has been experimentally verified, the long-term behaviour of rain attenuation induced on a microwave path in tropical regions is approximated by a gamma distribution. In this paper, the outage performance analysis of a satellite-terrestrial diversity reception system operating at frequencies above 10 GHz is presented, employing spatially correlated gamma fading channels. The receiver combines the satellite signal with the signal received by a terrestrial network using either the Maximal Ratio Combining or the Selection Combining techniques. Extended numerical results present the impact of various operational, geometrical and geographical parameters on the outage system performance.
CRISPR Genome Engineering for Human Pluripotent Stem Cell Research (2017)

The emergence of targeted and efficient genome editing technologies, such as repurposed bacterial programmable nucleases (e.g., CRISPR-Cas systems), has abetted the development of cell engineering approaches. Lessons learned from the development of RNA-interference (RNA-i) therapies can spur the translation of genome editing, such as those enabling the translation of human pluripotent stem cell engineering. In this review, we discuss the opportunities and the challenges of repurposing bacterial nucleases for genome editing, while appreciating their roles, primarily at the epigenomic granularity. First, we discuss the evolution of high-precision, genome editing technologies, highlighting CRISPR-Cas9. They exist in the form of programmable nucleases, engineered with sequence-specific localizing domains, and with the ability to revolutionize human stem cell technologies through precision targeting with greater on-target activities. Next, we highlight the major challenges that need to be met prior to bench-to-bedside translation, often learning from the path-to-clinic of complementary technologies, such as RNA-i. Finally, we suggest potential bioinformatics developments and CRISPR delivery vehicles that can be deployed to circumvent some of the challenges confronting genome editing technologies <i>en route</i> to the clinic.
Lipid and Apoprotein Profile in HIV-1-Infected Patients After CD4-Guided Treatment Interruption (2008)

The lipid profile and apoproteins levels change toward a less atherogenic profile after TI, arguing against a lipid-mediated mechanism to explain the increased cardiovascular risk in patients who interrupt treatment.
A Comparison of in-Process Tool Wear Measurement Methods in Turning (1986)

This paper reports on a study into comparisons of different methods of tool wear assessment in turning. There is still a great deal of controversy about the usefulness and sensitivity of the different types of device which are commercially available. The work reported here describes the possible methods of measuring wear for in-process applications, and defines those which have been commercialised. It then goes on to discuss the sensitivity of the useful methods and tabulates them for increasing sensitivity. This is based upon logical argument and the experience of other researchers. The paper then describes actual testing carried out by one of the authors and gives results for vibration, tool force and power sensing of wear. The results of the tests supported the sensitivity tabulation already noted which places power, vibration and tool force sensing in an ascending order of sensitivity.
Decreased expression of interleukin‐2 binding molecules (p70/75) in T cells from patients with systemic lupus erythematosus (1989)

Using radiolabeled interleukin-2 (IL-2), affinity cross-linking and binding assays revealed that the expression of intermediate-affinity IL-2 binding molecules (p70/75) on freshly prepared T cells from patients with systemic lupus erythematosus (SLE) was significantly decreased in comparison with that in normal subjects. The proliferative response of T cells to high doses of IL-2 was also reduced in patients with SLE. The decreased expression of p70/75 reflects the hyporesponsiveness to IL-2 of T cells in patients with SLE.
Concentration and separation of glycyrrhizic acid by foam separation (2002)

Abstract By the aid of the surface activities of glycyrrhizic acid, foam separation can be used to extract and concentrate it. The effects of operating parameters such as flow rate of air, initial feed concentration, pH and ionic strength on the enrichment ratio and recovery yield of glycyrrhizic acid are investigated in detail. In addition, the influences of other surface‐active substances in solution, such as proteins, on the separation of glycyrrhizic acid are also discussed. The experimental results show that foam separation is a simple and effective method to separate and concentrate glycyrrhizic acid. © 2002 Society of Chemical Industry
Variations in ribosomal DNA and mitochondrial DNA among chromosomal species of subterranean mole rats (1996)

Restriction site variations in nuclear ribosomal DNA (rDNA) spacers and mitochondrial DNA (mtDNA) were examined in several populations of mole rats with variable numbers of chromosomes, which represented the two superspecies Spalax leucodon (2n = 38, 54, or 62) and Spalax ehrenbergi (2n = 52, 54, 58, or 60). Sequence divergence of rDNA spacers between the members of the superspecies was approximately 8%, while the variation within each superspecies was 4% on average. The intrasuperspecies differentiation of rDNA spacers was generally associated with changes in the diploid number of chromosomes. However, substantial divergence (approximately 1.5%) was also detected among populations with the same diploid number of chromosomes. The sequence divergence of mtDNA among haplotypes of S. ehrenbergi was 10% or higher and among haplotypes of S. leucodon it was approximately 12%. By contrast, the range of sequence divergence between superspecies was 7.4%-12%. The large divergence of mtDNAs within each superspecies of mole rats may be explained by the preservation of ancient mtDNA polymorphisms.
Iterative weighted interference cancellation for CDMA systems with RAKE reception (2003)

The performance of CDMA systems can be severely degraded by interference, including both intersymbol interference (ISI) and the interference between users (co-channel interference) due to the non-orthogonality of the PN codes. We consider a system that uses a RAKE receiver along with a weighted iterative interference cancellation (IC) scheme to combat both ISI and co-channel interference. The resultant decoding scheme offers significant performance improvement over a conventional RAKE receiver with a complexity much less than that of maximum-likelihood decoding. We discuss the features and advantages of our proposed scheme and also provide simulation results for its BER performance for different numbers of users and weighting factors.
Properties of fucoidan from <i>Cladosiphon okamuranus</i> tokida in gastric mucosal protection (2000)

To elucidate the anti-ulcer potential of Cladosiphon fucoidan, anti-peptic activity, bFGF stabilizing activity and inflammatory properties of this and related substances were investigated. Anti-peptic activity was observed with this and other sulfated polysaccharides such as dextran sulfate, carrageenan, and Fucus fucoidan. However, non-sulfated polysaccharides such as mannan and dextran did not exert the anti-peptic activity. The loss of bFGF bioactivity was prevented by all sulfated polysaccharides tested except chondroitin sulfate, at pH 7.4 and at pH 4.0. At pH 2.0, only heparin protected the bFGF activity. The generation of superoxide by macrophages and PMNs was stimulated by dextran sulfate, carrageenan, and Fucus fucoidan, whereas Cladosiphon fucoidan, heparin and chondroitin did not. Dextran sulfate, carrageenan, and Fucus fucoidan also stimulated the secretion of TNFalpha from macrophages, while Cladosiphon fucoidan did not. Thus, Cladosiphon fucoidan is a sulfated polysaccharide without inflammatory action. These results suggest that Cladosiphon fucoidan is a safe substance with potential for gastric protection.
Convenient and Multistep Preparation of Oligopyridines Bearing Multiple Dansyl and Nitroxide Radicals (2003)

A series of pyridine and bipyridine molecules combining dual fluorescent (dansyl) and magnetic (free radical) probes has been prepared by a linear multistep protocol from the corresponding monodansylated derivatives. The grafting of the flexible aliphatic radical is realized by the use of a chloromethylnitronyl nitroxide derivative under basic conditions and with KI as a mediator. The synthetic potential of 2-[(5-dimethylamino-1-naphthalenesulfon-amide)methyl]-6-formylpyridine is assessed by the construction, in a first step, of an aliphatic nitroxide radical and subsequently of an additional aromatic radical. The synthetic methods reported herein provide a practical approach to the rational design of ligands bearing various kinds of functionalities such as chromogenic and spin-labeled fragments. A significant merit of this method is that it allows the introduction of the fluorescent substituent onto the pyridine or bipyridine framework at the beginning of the synthetic protocol.
Evidence for a Cysteine‐Histidine Thioether Bridge in Functional Units of Molluscan Haemocyanins and Location of the Disulfide Bridges in Functional Units <i>d</i> and <i>g</i> of the <i>β<sub>c</sub></i>‐Haemocyanin of <i>Helix Pomatia</i> (1997)

In functional units d and g from the betaC-haemocyanin of the gastropod Helix pomatia, aminoacid analysis in the presence of dimethyl sulfoxide showed the occurrence of seven cysteine residues. Titration with 5,5'-dithiobis(2-nitrobenzoic acid), however, did not reveal any free thiol group. Pepsinolysis at pH 2.0 followed by amino acid analysis and partial sequencing of the cysteine-containing peptides showed that six cysteine residues are involved in the formation of three disulfide bridges at corresponding positions. The results indicated that the remaining cysteine residue is linked by a thioether bridge to a histidine residue located two positions further in the sequence (H. pomatia d Cys60 His62; H. pomatia g Cys66 His68). This residue corresponds to one of the three histidine residues considered to be involved in the coordination of the copper A atom of the dinuclear copper group of the functional units. The presence of the thioether bond was further evidenced by an absorption band at 255 nm and by molecular mass determinations with electrospray mass spectrometry on a peptic peptide from H. pomatia d and on peptides obtained by proteolysis of carboxymethylated H. pomatia d with trypsin and pronase. Upon sequence analysis the cysteine-histidine thioether bridge was cleaved into didehydroalanine (polymers) and 2-thiolhistidine. A peptide with a cysteine-histidine thioether bridge was isolated from pepsinolysates of functional units c, e, f, g and h of Sepia officinalis and unit g of Octopus vulgaris, obtained from haemocyanin of the cephalopods S. officinalis and O. vulgaris. A cysteine-histidine thioether bridge, which was reported previously for tyrosinase of Neurospora crassa, thus seems to be a general feature for functional units of molluscan haemocyanins.
Mouse Macrophages Carrying Both Subunits of the Human Interferon-γ (IFN-γ) Receptor Respond to Human IFN-γ but Do Not Acquire Full Protection against Viral Cytopathic Effect (1996)

Studies of hamster-human and mouse-human somatic fibroblast hybrids and transfected mouse fibroblasts have demonstrated that signaling through the human interferon-gamma receptor (hu-IFN-gammaR) requires the formation of a complex consisting of ligand (IFN-gamma), a ligand binding receptor chain (IFN-gammaR1), and a signal transducing receptor chain (IFN-gammaR2). To date, the ability of this receptor complex to transduce the full repertoire of biological signals has been difficult to assess due to the limited number of activities that IFN-gamma can exert on fibroblasts. The current report assesses the ability of hu-IFN-gammaR chains to transduce signals in the absence of background human gene products by expressing hu-IFN-gammaR2 in a transformed macrophage cell line (F10/96) derived from a hu-IFN-gammaR1 transgenic mouse. Our results indicate that F10/96 clones expressing both human receptor proteins bind hu-IFN-gamma with an affinity comparable to that of human cells. Binding of either human or mouse IFN-gamma to its respective receptor elicits classic IFN-gamma responses such as up-regulation of major histocompatibility complex antigens, enhanced expression of IRF-1, and increased production of NO2- radicals, interleukin-6, tumor necrosis factor-alpha, and granulocyte macrophage-colony stimulating factor. However, hu-IFN-gamma could not fully protect the clones from cytopathic effects of encephalomyocarditis virus and vesicular stomatitis virus while mo-IFN-gamma could. These results demonstrate that while co-expression of hu-IFN-gammaR1 and hu-IFN-gammaR2 is necessary and sufficient for most IFN-gamma-induced responses, it is not sufficient to confer a generalized antiviral state. These findings further suggest that additional species-specific accessory factor(s) are necessary for full signaling potential through the IFN-gamma receptor complex. The nature and potential role of such factors in IFN-gammaR signaling is discussed.
A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia (2015)

Herein, we present a novel imaging platform to study the biological effects of non-invasive radiofrequency (RF) electric field cancer hyperthermia. This system allows for real-time in vivo intravital microscopy (IVM) imaging of radiofrequency-induced biological alterations such as changes in vessel structure and drug perfusion. Our results indicate that the IVM system is able to handle exposure to high-power electric-fields without inducing significant hardware damage or imaging artifacts. Furthermore, short durations of low-power (< 200 W) radiofrequency exposure increased transport and perfusion of fluorescent tracers into the tumors at temperatures below 41°C. Vessel deformations and blood coagulation were seen for tumor temperatures around 44°C. These results highlight the use of our integrated IVM-RF imaging platform as a powerful new tool to visualize the dynamics and interplay between radiofrequency energy and biological tissues, organs, and tumors.
Chemotaxis and Calcium Responses of Phagocytes to Formyl Peptide Receptor Ligands Is Differentially Regulated by Cyclic ADP Ribose (2004)

Cyclic ADP ribose (cADPR) is a calcium-mobilizing metabolite that regulates intracellular calcium release and extracellular calcium influx. Although the role of cADPR in modulating calcium mobilization has been extensively examined, its potential role in regulating immunologic responses is less well understood. We previously reported that cADPR, produced by the ADP-ribosyl cyclase, CD38, controls calcium influx and chemotaxis of murine neutrophils responding to fMLF, a peptide agonist for two chemoattractant receptor subtypes, formyl peptide receptor and formyl peptide receptor-like 1. In this study, we examine whether cADPR is required for chemotaxis of human monocytes and neutrophils to a diverse array of chemoattractants. We found that a cADPR antagonist and a CD38 substrate analogue inhibited the chemotaxis of human phagocytic cells to a number of formyl peptide receptor-like 1-specific ligands but had no effect on the chemotactic response of these cells to ligands selective for formyl peptide receptor. In addition, we show that the cADPR antagonist blocks the chemotaxis of human monocytes to CXCR4, CCR1, and CCR5 ligands. In all cases, we found that cADPR modulates intracellular free calcium levels in cells activated by chemokines that induce extracellular calcium influx in the apparent absence of significant intracellular calcium release. Thus, cADPR regulates calcium signaling of a discrete subset of chemoattractant receptors expressed by human leukocytes. Since many of the chemoattractant receptors regulated by cADPR bind to ligands that are associated with clinical pathology, cADPR and CD38 represent novel drug targets with potential application in chronic inflammatory and neurodegenerative disease.
Barium Titanate Nanoparticles in Block Copolymer (2001)

Cubic BaTiO3 particles of ∼10 nm were crystallized predominantly within the hydroxylated polybutadiene matrix of a phase separated triblock copolymeric thin film of polystyrene−polybutadiene−polystyrene (Kraton D1102). The barium titanated Kraton thin film had remnants of the cylindrical morphology of a plain Kraton thin film with an interdomain spacing of ∼23 nm. The procedure of barium titanation consisted of three steps: (1) in situ hydroxylation of the polybutadiene matrix of an annealed Kraton thin film, (2) regioselective deposition of barium titanium methoxypropanoxide (BaTi(OCH2CH(CH2)OCH3)6) on the hydroxylated polybutadiene matrix, and (3) hydrothermal reduction of the organometallic complexes in an NH3/H2O atmosphere at 80 °C for 24 h. Isolated water clusters in step 3, condensed from the NH3/H2O atmosphere of 1 M NH4OH(aq) at 80 °C in the alkoxide−Kraton films, were believed to have a typical diameter of no more than 23 nm at a pH of 14. They gave a high pH environment to weaken the chelating effect among alkoxides and the organic matrix and provided a spatial confinement for the localized nucleation and growth of cubic BaTiO3 nanoparticles.