gebhart/patrepeval huggingface dataset:
Holistic Molecular Approaches for Anticancer Therapy (2012)

Cancer is a threat concomitant with human history. Although we have stepped into the very advanced twenty first century with considerable progress in cancer treatment, it is still a very difficult disease to treat and is the second most common disease that causes mortality. In recent years, the discovery of new anticancer drugs has evolved from a dramatic shift from cell based screening for anti proliferative effects to a more mechanistically based approach that targets the specific molecular lesions thought to be responsible for the development and maintenance of the malignant phenotype in various forms of cancer. The development of molecularly targeted drugs has improved the efficacy and selectivity of cancer treatment by exploiting the differences between cancer cells and normal cells. Targeted therapies are now a component of treatment for many types of cancer, including breast, colorectal, lung and pancreatic as well as lymphoma, leukemia and multiple myeloma. In order to enhance the specificity and efficacy of current cancer therapies, the aim of this review is to shed light on some of the important molecular targets.
KEYWORDS: Cancer, Apoptosis, Cell signalling, Therapeutic targets.
Évolution des grands pivots vers le type à patins équilibrés (1959)

Casacci Séverin, Jarriand P. Évolution des grands pivots vers le type à patins équilibrés. In: Turbines et pompes hydrauliques. Compte rendu des cinquièmes journées de l'hydraulique, Aix-en-Provence, 26, 27 et 28 juin 1958. Tome 1, 1959.
Determining Health-Related Quality-of-Life Outcomes Using the SF-6D Following Total Hip Arthroplasty (2017)

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Heterotopic heart transplantation in 1988--recent selective indications and outcome. (1989)

Considering a worldwide average 1-year survival rate of nearly 90% after orthotopic heart transplantation, the question arises as to whether there is still an indication for heterotopic heart transplantation. Since 1967, 132 heart transplantations have been performed at our institution. From 1974 to 1983 only heterotopic transplantations were performed. Since 1985, quadruple-drug therapy has been used for immunosuppression. This consists of low dose cyclosporine in combination with azathioprine, methylprednisolone (in lower dosages), and rabbit antithymocyte globulin (for the first 4 to 6 days after operation and as rescue therapy for severe rejections). Fifty-five transplantations have been performed with this therapy (44 orthotopic and 11 heterotopic). The indications for heterotopic transplantations were either elevated pulmonary vascular resistance (4 to 6 Wood units, n = 6), or a gross donor and recipient weight mismatch (more than 20%) in candidates who showed signs of severe cardiac decompensation (n = 6). One patient had both indications. The 1-year survival rate for those patients was 83%. Currently seven of the 11 patients are alive with life spans ranging from 6 months to 2.5 years after operation. Causes of deaths were infections (n = 3) and chronic graft rejection (n = 1). The recipients were restudied with right-sided heart catheterizations performed from 2 months to 2 years after transplantation. In all patients the cardiac output increased significantly from a mean of 4.0 to 5.8 L/min (p less than 0.0005). In patients with elevated pulmonary vascular resistance, this value decreased after heterotopic transplantation from a mean of 4.9 to 2.4 Wood units.(ABSTRACT TRUNCATED AT 250 WORDS)
Impact of Severity of Illness Bias and Control Group Misclassification Bias in Case-Control Studies of Antimicrobial-Resistant Organisms (2005)

Requiring control-patients to have at least one clinical culture introduces a selection bias likely because it eliminates patients with less severe illness.
Is Coronavirus an Issue in Produce Production (2020)

CDC, FDA and USDA have no reports at this time of human illnesses that suggest coronavirus can be transmitted by food or food packaging. Research on similar viruses, such as SARS and influenza, show risk of transmission from food is very low. While information on if or how long virus persists on surfaces is minimal, risk of foodborne transmission is low and should not be of concern. This flyer, written by Natalie Seymour, Mary Yavelak, Candice Christian, and Ben Chapman (NC State University Extension), provides answers to some frequently asked questions about coronavirus and produce production. Published by the UF/IFAS Food Science and Human Nutrition Department.
Revised April 21, 2020: Changes were made relating to physical distancing, mask usage and monitoring employee health when exposed to the virus.
The impact of AOA energy distribution on the spatial fading correlation of linear antenna array (2003)

In this paper, we present the comparative spatial fading correlation function of a uniform linear array (ULA) for various angle-of-arrival (AOA) distributions in a mobile radio environment. The spatial fading correlation for ULA is a function of the angle spread and distance between elements. Angle spread is a measure of the energy distribution in AOA and is defined to be the variance in this work. Three AOA distributions are considered in this work: uniform, truncated Gaussian, and Laplacian. Results show that the three AOA distributions give similar spatial fading correlation for the same angle spread suggesting that the variance of the distribution is more important than the actual distribution. Computer simulations are carried out to verify the analytical results.
2. Upper extremity injuries (1993)

Abstract This self-directed learning module highlights recent advances in this topic area. It is part of the chapter on sports medicine in the Self-Directed Medical Knowledge Program for practitioners and trainees in physical medicine and rehabilitation. In this article, shoulder and elbow problems of the throwing athlete are emphasized. Common injuries involving the wrist and hand are also covered.
Temperature and Pressure Dependence of the Viscosity of the Ionic Liquids 1-Hexyl-3-methylimidazolium Hexafluorophosphate and 1-Butyl-3-methylimidazolium Bis(trifluoromethylsulfonyl)imide (2007)

The viscosities of the ionic liquids 1-methyl-3-hexylimidazolium hexafluorophosphate, [HMIM]PF6, and 1-butyl-3-methylimidazolium bis(trifluorosulfonyl)imide, [BMIM][Tf2N], have been measured between (0 and 80) °C and at maximum pressures of 238 MPa ([HMIM]PF6) and 300 MPa ([BMIM][Tf2N]) at 75 °C with a falling-body viscometer. The overall uncertainty is estimated at ± 2 %. Modified Litovitz and Vogel−Fulcher−Tammann (VFT) equations are used to represent the temperature and pressure dependence. The Angell equation relating the strength factor D, the VFT parameter T0, and the glass temperature Tg is confirmed. Densities between (0 and 90) °C at atmospheric pressure with an overall uncertainty estimated at ± 0.000 05 g·cm-3 are also reported.
Communiaction (2000)

A vision that is not enacted is a dream. Building the framework for change starts the process of change but now it has to be acted upon. The first step is to communicate the vision to the whole organisation. This has to be done quickly but, more importantly, effectively. The people who have been involved in forming the vision understand it because they have worked through its development. They have considered the options and argued their views. They have invested emotional and intellectual energy in it. They have lived through the decisions and understand why they were taken. These are decisions that are going to effect everybody in the organisation.KeywordsSenior ManagerChange ProjectLeadership SkillDynamic OrganisationControl Management SystemThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Molecular Weights of Homogeneous Samples of Deoxyribonucleic Acid Determined from Hydrodynamic Theories for the Wormlike Coil (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular Weights of Homogeneous Samples of Deoxyribonucleic Acid Determined from Hydrodynamic Theories for the Wormlike CoilJohn E. Hearst, Carl W. Schmid, and Frank P. RinehartCite this: Macromolecules 1968, 1, 6, 491–494Publication Date (Print):November 1, 1968Publication History Published online1 May 2002Published inissue 1 November 1968https://pubs.acs.org/doi/10.1021/ma60006a007https://doi.org/10.1021/ma60006a007research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Multiresolution texture analysis for classification of mass and normal breast tissue on digital mammograms</title> (1995)

We are investigating the use of texture features to distinguish abnormal from normal tissue for computer-aided diagnosis algorithms. In this study, the improvement in the accuracy of classifying masses from normal breast tissue on digitized mammograms by using local texture features was evaluated. One hundred and sixty-eight mammograms were randomly selected from patient files and digitized with a laser scanner at a pixel size of 100 micrometers . Four different regions of interest (ROIs), each of 256 X 256 pixels, were selected manually from each of the digitized mammograms. One of the four ROIs contained a biopsy-proven mass and the other three contained normal parenchyma including dense, mixed dense/fatty, and fatty tissues. The mass ROIs were randomly and equally divided into a training and a test group along with corresponding normal ROIs from the same film. The wavelet transform was used to decompose the ROIs into several scales. Global multiresolution texture features were calculated from the spatial gray level dependence matrices of the low-pass wavelet coefficients up to a certain scale and then at variable distances between the pixel pairs. Texture features and their differences in suspicious object sub-region and its peripheral sub-regions of the ROIs were also calculated to form a local texture feature space. Stepwise linear discriminant analysis was used to select effective features from the combined global-local feature space to maximize the separation of mass and normal tissue for all ROIs. Receiver operating characteristic (ROC) analysis was used to evaluate the classification accuracy and its improvement using features from global and local feature spaces. Using the global multiresolution feature space alone, it was found that the texture features at large pixel distances were important for the classification task. Using local features only, the classification accuracy was comparable to that of the global features. With the combined global and local feature spaces, the average area, A<SUB>z</SUB>, under the ROC curve reached 0.91 and 0.90 for the training and test groups, respectively. The improvement was statistically significant. The results demonstrate that a linear discriminant classifier using the combination of global multiresolution texture features and the local texture features can effectively classify masses from normal tissue on mammograms.
Ensuring data integrity in storage (2005)

Data integrity is a fundamental aspect of storage security and reliability. With the advent of network storage and new technology trends that result in new failure modes for storage, interesting challenges arise in ensuring data integrity. In this paper, we discuss the causes of integrity violations in storage and present a survey of integrity assurance techniques that exist today. We describe several interesting applications of storage integrity checking, apart from security, and discuss the implementation issues associated with techniques. Based on our analysis, we discuss the choices and trade-offs associated with each mechanism. We then identify and formalize a new class of integrity assurance techniques that involve logical redundancy. We describe how logical redundancy can be used in today's systems to perform efficient and seamless integrity assurance.
ChemInform Abstract: 1,2,4‐TRIAZOLE 19. MITT. NITRIERUNG VON 1,2,4‐TRIAZOLEN (1970)

Abstract Während die Nitrierung des Triazols (I) an der Aminogruppe erfolgt und zum Nitramin (II) (80% Ausbeute) führt, entstehen aus den Triazolen (III), da der Triazolring bei der Nitrierung von Phenyltriazolen gegenüber dem Phenylkern als Substituent 1. Ordnung wirkt und den neu eintretenden Substituenten in p‐Stellung dirigiert, die Nitroverbindungen IV (63, 79 bzw. 84%).
ChemInform Abstract: NIOBIUM ORGANOMETALLIC CHEMISTRY. PART III. REACTION OF BIS(CYCLOPENTADIENYL)NIOBIUM DICHLORIDE WITH TETRAPHOSPHORUS DECASULFIDE. ESR AND NMR STUDIES OF SOME NIOBIUM(IV) AND NIOBIUM(V) O,O′‐DIALKYLDITHIOPHOSPHATES (1980)

Abstract Die Reaktion von Dichloro‐bis‐[cyclopentadienyl]‐Nb(IV) mit alkoholischen Lösungen von P4810 liefert zwei Typen von Komplexen: 1. die paramagnetischen Nb(IV)‐Komplexe (I), die durch Zugabe von Ammoniumhexafluorophosphat isoliert und IR‐ sowie ESR‐ spektroskopisch charakterisiert werden.
Biomarkers of nephrotoxicity in children environmentally exposed to lead in Poland (1999)

Nephropathy has been reported in children with overt lead intoxication. Only recently low-level lead exposure has been associated with renal effects, especially with regard to tubular function. The objective of the present study was to investigate the relation between lead exposure and renal function in children in the Katowice region, an industrial area in Poland. This cross-sectional study involved 157 children, aged 4–14 years. Blood lead concentration was used as an index of lead exposure. Glomerular filtration rate was estimated using the height adjusted serum creatinine calculation (crea-GFR) and measurement of cystatin C in serum. The renal tubular function was evaluated by measuring the urinary concentration of protein HC. The median blood lead concentration was 0.35 μmol/L (72 μg/L) with a range of 0.09–1.36 μmol/L. Crea-GFR (n = 143) decreased significantly (p = 0.002) with increasing concentrations of lead in the blood. Serum cystatin C (n = 84) increased with blood lead (p = 0.004). There was an association (p = 0.002) between blood lead and urinary concentration of protein HC (n = 49). In summary, the present findings indicate that the association between blood lead and the markers of renal function on both a glomerular and a tubular level may be caused by environmental lead exposure. Copyright © 1999 John Wiley & Sons, Ltd.
Resource Allocation by Convex Monotonous Programming Application to an Otec Energy Production Platform (1983)

A problem is considered of the minimization of a convex and monotonically increasing cost function subject to an upper bound of a convex and monotonically decreasing failure probability function. An algorithm is defined for the parametrical solution of the problem with respect to the selected failure probability level; the algorithm is applicable to problems with cost and failure probability functions that are not necessarily separable, thus extending a previously given algorithm for separable functions. A condition is given for the relaxation of the convexity assumption on the functions, and it is observed that the problem of the minimization of the failure probability subject to an upper bound on the total cost is solved simultaneously with the given problem. An anlytically solvable numerical example is given and an application to the optimization of an OTEC energy production platform is briefly described, with reference to a complete description; it is concluded that the given extension of the algorithm to non-convex functions is important in this application.
New directions in teaching the fundamentals of computer science --- discrete structures and computational analysis (1973)

Since the publication of the Curriculum 68 report of the ACM Committee [CUR 68], undergraduate computer science programs have undergone substantial changes. Notably, many courses previously taught at the graduate level have shifted down to the undergraduate level; new areas have developed and consolidated but were not covered by the ACM report. These facts make it necessary to revise and update the Curriculum 68 report. An important factor which could help the revision is the actual experience gained through the development of many new undergraduate computer science programs since the publication of Curriculum 68 report five years ago. More specifically, most recommendations of the ACM report contain just the subject areas to be taught. The actual teaching experiences of these courses have formulated certain basic philosophies and formats of presentation. It is helpful, in our opinion, to compare the merits of these philosophies and formats of presentation.
Inter- and intrapopulation variation in the defensive chemistry of the red seaweed <i>Laurencia dendroidea</i> (Ceramiales, Rhodophyta) (2013)

Oliveira A.S., Sudatti D.B., Fujii M.T., Rodrigues S.V. and Pereira R.C. 2013. Inter- and intrapopulation variation in the defensive chemistry of the red seaweed Laurencia dendroidea (Ceramiales, Rhodophyta). Phycologia 52: 130–136. DOI: 10.2216/12-058.1Variation in the production of defensive chemicals by seaweeds is an important feature to understand the ecological and evolutionary aspects of the predator–prey interactions in marine systems. In this study, we evaluated the inter- and intrapopulation variations in the amount of elatol, which is a sesquiterpene produced as a chemical defence in specimens from four populations of the red seaweed Laurencia dendroidea along the Brazilian coast. The concentration of elatol varied from 2 to 10 times among the L. dendroidea individuals but was approximately three orders of magnitude broader among the populations from 0.001% to 1.24% of the dry weight. The specimens collected at lower latitudes produced low amounts of defences, which did not support the hypothesis that chemical defences increase with a decrease in latitude. When cultivated under distinct temperatures, L. dendroidea specimens produced more defences (= elatol) under high temperatures (25°C). Although we observed a genotypic relevance for chemical defence, the environmental differences along the Brazilian coast support the hypothesis that the variability observed in elatol production by L. dendroidea was most likely influenced by small-scale changes in environmental factors.
Proving secrecy is easy enough (2005)

Abstract: We develop a systematic proof procedure for establishing secrecy results for cryptographic protocols. Part of the procedure is to reduce messages to simplified constituents, and its core is a search procedure for establishing secrecy results. This procedure is sound but incomplete in that it may fail to establish secrecy for some secure protocols. However, it is amenable to mechanization, and it also has a convenient visual representation. We demonstrate the utility of our procedure with secrecy proofs for standard benchmarks such as the Yahalom protocol.
Parameter optimization for vocal tract length normalization (2002)

This paper focuses on the optimization of model parameters for vocal tract length normalization (VTLN). For maximum likelihood (ML) based normalization techniques, the complexity of the VTL-models is a source of variation in system performance. An optimal complexity for the VTL-model that ensures best global word error rate is proposed. The choice of frequency warping factor also depends on the signal processing step of VTLN. A best set of parameters for the VTLN signal processing stage is proposed with extensive results for an optimal frequency range.
Anonymous Gossip: improving multicast reliability in mobile ad-hoc networks (2002)

In recent years, a number of applications of ad-hoc networks have been proposed. Many of them are based on the availability of a robust and reliable multicast protocol. We address the issue of reliability and propose a scalable method to improve packet delivery of multicast routing protocols and decrease the variation in the number of packets received by different nodes. The proposed protocol works in two phases. In the first phase, any suitable protocol is used to multicast a message to the group, while in the second concurrent phase, the gossip protocol tries to recover lost messages. Our proposed gossip protocol is called Anonymous Gossip (AG) since nodes need not know the other group members for gossip to be successful. This is extremely desirable for mobile nodes, that have limited resources, and where the knowledge of group membership is difficult to obtain. As a first step, anonymous gossip is implemented over MAODV without much overhead and its performance is studied. Simulations show that the packet delivery of MAODV is significantly improved and the variation in number of packets delivered is decreased.
Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles. (2011)

PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. This study investigates the impact of rotary ball milling on the physical properties of PLGA and its influence on nanoparticle formation prepared using the solvent displacement technique. By applying mechanical stress to the polymer and altering its physical appearance and molecular weight, the loading of lansoprazole within the nanoparticles was increased to 96%, with a reduction in particle size. The results indicate that rotary ball milling significantly reduces particle size, increases lansoprazole loading and improves the release profile for lansoprazole loaded PLGA nanoparticles.
Association of markers with histology in cohort 1. (2015)

<p>H-scores of nestin (A) were significantly higher in sarcomatoid MPM whereas the diagnostic epithelioid markers podoplanin/D2-40 (B) and calretinin (C) were significantly decreased in sarcomatoid MPM; Mann-Whitney U tests.</p>
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria (2016)

Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory responses, parasite sequestration in tissues and vascular dysfunction. Production of pro-inflammatory cytokines and chemokines promotes endothelial activation as well as recruitment and infiltration of inflammatory cells, which in turn triggers further endothelial cell activation and parasite sequestration. Inflammatory responses are triggered in part by bioactive parasite products such as hemozoin and infected red blood cell-derived extracellular vesicles (iRBC-derived EVs). Here we demonstrate that such EVs contain functional miRNA-Argonaute 2 complexes that are derived from the host RBC. Moreover, we show that EVs are efficiently internalized by endothelial cells, where the miRNA-Argonaute 2 complexes modulate target gene expression and barrier properties. Altogether, these findings provide a mechanistic link between EVs and vascular dysfunction during malaria infection.