gebhart/patrepeval huggingface dataset:
Core-PC: A Class of Correlative Power Control Algorithms for Single Channel Mobile Ad Hoc Networks (2007)

In this paper we study the correlations that exist between the required transmission power of RTS, CTS, DATA and ACK frames to guarantee a successful 4-way handshake in wireless ad hoc networks based on the IEEE 802.11 distributed coordination function (DCF). From these correlations, and starting from a set of different initial conditions, we can derive a class of power controlled media access control (MAC) algorithms for single channel ad hoc networks based on the existing IEEE 802.11 DCF. From substantial simulations of the different algorithms and comparison to some prominent alternatives, we come to a conclusion that contradicts the intuitively sound, commonly held belief which states that sending control frames at maximum power - to reduce interference on the long data frames - then, the ensuing long data frames at a lower, yet sufficient power level decreases power consumption per carried bit.
Loop Free RPL (2013)

The IETF has developed the IPv6 based standards for Low-power and
Lossy Networks (LLNs) to meet requirements of constrained
applications, such as field monitoring, inventory control and so on.
The IPv6 Routing Protocol for LLNs (RPL) was published as [RFC6550] in
March 2012. Based on routing metrics and constraints [RFC6551], RPL
builds Directed Acyclic Graph (DAG) topology to establish
bidirectional routes for LLNs for traffic types of multipoint-to-
point, point-to-multipoint, and point-to-point. RPL routes are
optimized for traffic to or from one or more roots that act as sinks.
As a result, a DAG is partitioned into one or more Destination
Oriented DAGs (DODAGs), one DODAG per sink. RPL is widely considered
as a feasible routing protocol for LLNs. However, DODAG loops and lack
of a loop free DODAG local repair mechanism are two open issues to be
addressed. This draft introduces an alternative rank and an Objective
Function to eliminate DODAG loops in RPL. Based on the proposed rank
and Objective Function, this draft introduces a loop free RPL.
Multilocus Sequence Typing Has Better Discriminatory Ability for Typing <i>Vibrio cholerae</i> than Does Pulsed-Field Gel Electrophoresis and Provides a Measure of Phylogenetic Relatedness (2003)

Twenty-two Vibrio cholerae isolates, including some from "epidemic" (O1 and O139) and "nonepidemic" serogroups, were characterized by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) by using three housekeeping genes, gyrB, pgm, and recA; sequence data were also obtained for the virulence-associated genes tcpA, ctxA, and ctxB. Even with the small number of loci used, MLST had better discriminatory ability than did PFGE. On MLST analysis, there was clear clustering of epidemic serogroups; much greater diversity was seen among tcpA- and ctxAB-positive V. cholerae strains from other, nonepidemic serogroups, with a number of tcpA and ctxAB alleles identified.
Direct and indirect interactions of the dopamine D3 receptor with glutamate pathways: implications for the treatment of schizophrenia (2012)

This article, based on original data as well as on previously reported preclinical and clinical data that are reviewed, describes direct and indirect interactions of the D(3) receptor with N-methyl-D-aspartate receptor (NMDA) signaling and their functional consequences and therapeutic implications for schizophrenia. D(3) receptor immunoreactivity at ultrastructural level with electron microscopy was identified at presumably glutamatergic, asymmetric synapses of the medium-sized spiny neurons of the nucleus accumbens. This finding supports the existence of a direct interaction of the D(3) receptor with glutamate, in line with previously described interactions with NMDA signaling involving Ca(2+)/calmodulin-dependent protein kinase II at post-synaptic densities (Liu et al. 2009). Indirect interactions of the D(3) receptor with glutamate could involve a negative control exerted by the D(3) receptor on mesocortical dopamine neurons and the complex regulation of the glutamatergic pyramidal cells by dopamine in the prefrontal cortex. This could be exemplified here by the regulation of pyramidal cell activity in conditions of chronic NMDA receptor blockade with dizocilpine (MK-801). BP897, a D(3) receptor-selective partial agonist, reversed the dysregulation of cortical c-fos mRNA expression and pyramidal cell hyperexcitability, as measured by paired-pulse electrophysiology. At the behavioral level, blockade of the D(3) receptor, by known D(3) receptor antagonists or the novel D(3) receptor-selective antagonist F17141, produces antipsychotic-like effects in reversing hyperactivity and social interaction deficits induced by NMDA receptor blockade by MK-801 in mice. The glutamate-D(3) receptor interactions described here offer a conceptual framework for developing new D(3) receptor-selective drugs, which may appear as an original, efficacious, and safe way to potentially indirectly target glutamate in schizophrenia.
Highly stereocontrolled synthesis of some polyfunctionalized cyclohexenes. A short formal total synthesis of (.+-.)-chorismic acid (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly stereocontrolled synthesis of some polyfunctionalized cyclohexenes. A short formal total synthesis of (.+-.)-chorismic acidGary H. Posner, Alberto Haces, Wayne Harrison, and Chris M. KinterCite this: J. Org. Chem. 1987, 52, 22, 4836–4841Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/jo00231a002https://doi.org/10.1021/jo00231a002research-articleACS PublicationsRequest reuse permissionsArticle Views682Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Incidence and Clinical Course of Peripheral Neuropathy in Patients Receiving Thalidomide for the Treatment of Multiple Myeloma. (2005)

Abstract Background: Although thalidomide induced neuropathy has been described for decades, many features such as incidence, risk factors, severity and character of the neuropathy are not well defined. We retrospectively reviewed the incidence and clinical course of peripheral neuropathy in patients treated with thalidomide or thalidomide/dexamethasone (Thal/Dex) on a Phase II Mayo Clinic trial. Methods: Patients who participated in a Mayo Clinic Phase II trial of thalidomide in myeloma were studied. In this trial, patients with SMM and RMM received thalidomide 200 mg per day escalated as tolerated to a maximum of 800 mg/day. Patients with NMM received thalidomide 200 mg/day plus dexamethasone 40 mg/day orally on days 1–4, 9–12, 17–20 (odd cycles) and 40 mg/day days 1–4 (even cycles) repeated monthly. The incidence and clinical course of neuropathy was assessed by chart review. The study was approved by the Mayo Clinic Institutional Review Board. Results: All 113 patients (70 male, 43 female) treated on trial were studied; 31 patients with smoldering/indolent myeloma (SMM), 32 patients with relapsed/refractory myeloma (RMM) and 50 patients with newly diagnosed myeloma (NMM). Patients were accrued to the parent protocol from April 1999 through March 2002. The median age was 62 years (range, 36–78). The median duration of thalidomide therapy on protocol was 15 months in SMM, 6 months in RMM and 4 months in NMM. Overall, 63 patients (56 %) developed symptoms of peripheral neuropathy. The incidence of neuropathy was 77%, 50%, and 46% in patients with SMM, RMM, and NMM, respectively. Neuropathy worsened during the treatment phase with/without dose reduction or after cessation in 15%, remained stable in 52%, and improved in 27%. Overall grade of neuropathy was grade 1 in most pts; 11% of all patients had grade 2 neuropathy and 2% had grade 3 neuropathy. Predominant symptoms of neuropathy were tingling and numbness involving both upper limb and lower limbs. Small subsets of patients complained of hearing loss 6 patients), and erectile dysfunction (4 patients). Electromyographic studies and nerve conduction studies were performed in 11 patients; the most common finding was a length dependent axonal neuropathy. Conclusion: Peripheral neuropathy is an important and common adverse event with thalidomide therapy that often limits the dose and duration of treatment. Its incidence and severity are likely related to dose and duration of therapy.
Characterization of a common VIP-PACAP receptor in human small intestinal epithelium (1993)

Vasoactive intestinal peptide (VIP) receptors were characterized in epithelial plasma membranes from human small intestine. Native VIP inhibited the binding of 125I-labeled VIP to jejunal membranes, and Scatchard analysis of these data was consistent with the existence of one class of receptor with a dissociation constant of 42 pM and a maximal binding of 256 fmol/mg membrane protein. VIP stimulated adenylyl cyclase activity in human jejunal membranes in the 0.01 nM-1 microM range [half-maximal effective dose = 0.7 nM]. Coupling of VIP receptors with a Gs protein was further assessed by the ability of GTP (10(-8) to 10(-3) M) to inhibit 125I-VIP binding to membranes. 125I-VIP binding was seven to eight times higher in villus cells than in crypt cells. Finally, 125I-VIP binding was detectable throughout the small and large intestines with the highest binding in jejunum. Among the natural peptides structurally related to VIP, some inhibited 125I-VIP binding with the following order of potency: VIP = pituitary adenylate cyclase-activating peptide (PACAP)-27 = PACAP-38 > helodermin >> peptide histidine methionineamide = human growth hormone-releasing factor > secretin. The same order of potency of peptides for inhibiting 125I-VIP or 125I-labeled PACAP was observed, supporting that the two tracers bound to a common VIP-PACAP receptor site. This order of potency was also observed for the stimulation of adenylyl cyclase activity by these peptides. 125I-VIP was cross-linked to membranes using disuccinimidyl suberate. After sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis, one single band of 70,000 mol wt was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
Highly reliable and low-power nonvolatile cache memory with advanced perpendicular STT-MRAM for high-performance CPU (2014)

This paper presents a novel nonvolatile last level cache (LLC) based on the advanced perpendicular STT-MRAM to reduce the total power consumption of LLC. The presented LLC has novel readout circuit with the dual-sensing salvation scheme that enhances reliability of STT-MRAM along with typical error-correcting code (ECC). The comparison of CPU performance per power with SRAM-based, embedded DRAM and conventional STT-MRAM-based LLCs indicates that the presented novel nonvolatile LLC is the most suitable for large LLC.
Complete mitochondrial genome of a Neotropical dobsonfly Chloronia mirifica Navás, 1925 (Megaloptera: Corydalidae), with phylogenetic implications for the genus Chloronia Banks, 1908 (2016)

The complete mitochondrial (mt) genome of Chloronia mirifica Navás, 1925 was determined and analyzed. This represents the first mt genome of the Neotropical endemic dobsonfly genus Chloronia Banks, 1908. The mt genome of C. mirifica is a typical circular DNA of 15877 base pairs with an A+T 77.1%. It has an ancestral gene arrangement of the insect mt genome composed of 37 genes. Eleven of the 13 protein coding genes (PCGs) start with ATT and ATG, while nad6 and nad1 start with ATC and TTG respectively. Five PCGs end with a single T, while the others have a complete termination codon TAG or TAA. Most tRNAs are folded into the typical clover-leaf structure except for the trnS1 whose dihydrouridine arm is a simple loop. The secondary structure of rrnL consists of five structural domains and 50 helices, while the rrnS includes three domains and 34 helices. The phylogenetic analysis based on all 13 PCGs and two rRNA genes of the mt genome recovers Chloronia to be the sister group of Corydalus Latreille, 1802.
Incorporating phonetic properties in hidden Markov models for speech recognition (1997)

In this paper the incorporation of important phonetic properties into hidden Markov models (HMM) is studied. Phones have characteristic properties such as unique temporal structure, context sensitive behavior and specific duration, etc. New HMMs which incorporate the above properties with additional degrees of freedom to the standard HMM states are proposed. The use of each of the phonetic property for speech recognition is demonstrated using the new HMMs. All the algorithms required for using these new models in various applications of speech recognition have been presented. Experimental comparison with the standard discrete HMM for a speaker-independent continuous speech phone recognition task show that consistent improvement is achieved by the new models.
Influence of Undernutrition on the Histology and Histochemistry of the Bovine Endometrium (1972)

Infertility is commonly associated with undernutrition in beef heifers. (Warnick, Meade and Koger, 1960; McClure, 1961; Wiltbank et al., 1962; Wiltbank et al., 1964; McClure, 1965; Lamond, 1969). Uterine secretions are important for the nourishment of the unattached embryo in the uterine lumen as shown by metabolic requirements for embryos cultured in vitro and cases of sterility correlated with low endometrial glycogen content (Rubulis, Jacobs and Hughes, 1965). Inadequate nutrition can alter the delicate balance between the hypophysis and the gonad (Lutwak-Mann, 1958; Leathern, 1961) and, consequently, may upset the estrogen to progesterone relationship. The synergistic action of estrogen and progesterone upon the uterus is necessary for embryo survival and placentation (Wynn, 1967). The objectives of this study were to utilize histology and carbohydrate histochemistry as a means of describing the uterine environment associated with the development of the embryo prior to implantation and to determine if undernutrition can alter this environment.
New Biocidal N-Halamine-PEG Polymers (1998)

The synthesis and biocidal efficacies of two PEG-N-halamine polymers were reported. The N-halamines are classified as dichlorohydantoins and chloroimidazolidin-4-ones, which were attached to a methoxy-poly(ethylene glycol) terminated amine. A 1000 ppm solution of each N-halamine polymer was prepared in water and it was demonstrated that Staphylococcus aureus was inactivated (6 logs) when it was in contact with these polymeric solutions for ten minutes. The stability of these solutions was determined over prolonged periods of time, as well as the biocidal efficacies. These polymeric materials show commercial potential as surface active biocides if the polyethylene glycol) moiety can be anchored to a surface.
Editorial: why bad things happen to good systems, and what to do about it (2002)

Perfection in large software systems is improbable; therefore, it is prudent to enhance security by anticipating failures and preparing for contingencies. We propose an analogy with medicine, supporting curative as well as preventive action. Information technology (IT) security needs to allocate resources to contingency resolution mechanisms that can be used to complement prevention mechanisms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Avaliação do efeito da energia de soldagem sobre as tensões residuais resultantes em juntas soldadas com multipasse (2010)

A energia de soldagem pode ser ajustada tanto por meio do controle da potência (tensão e corrente de soldagem) quanto por meio da velocidade de soldagem. Tais formas de ajustes modificam os efeitos da energia de soldagem sobre a junta, o que pode influenciar de forma distinta as tensões residuais resultantes na mesma. Desta forma, o objetivo deste trabalho é avaliar o efeito da energia de soldagem, considerando seu ajuste através da alteração individual e independente da corrente e da velocidade de soldagem, sobre as tensões residuais resultantes em juntas soldadas com multipasse. Foram empregadas amostras de aço estrutural chanfradas em meio-v e soldadas utilizando eletrodo revestido. Aplicaram-se três energias de soldagem obtidas por meio de três níveis distintos de corrente e de velocidade de soldagem. As amostras foram levadas a um difratômetro de raios-x portátil onde foram levantados os perfis de tensões residuais na superfície das mesmas. Uma verificação importante foi que diferentes parâmetros de soldagem que resultam em aportes térmicos "iguais", geram níveis diferentes de tensões residuais, ou seja, a energia de soldagem não pode ser considerada de forma isolada em análises de níveis de tensões residuais resultantes da soldagem multipasse.
Frequency doubling of CO_2 laser radiation at 106 μm in the highly nonlinear chalcopyrite LiGaTe_2 (2007)

Type-I phase matching for second-harmonic generation at 10.6 microm in LiGaTe(2) is demonstrated by using a tunable single-frequency continuous-wave CO(2) laser, and the nonlinear coefficient of LiGaTe(2) is determined from comparison with AgGaSe(2). The effective nonlinearity of LiGaTe(2) for this process amounts to 34.5 pm/V.
Deficient α-galactosidase A activity in plasma but no Fabry disease – a pitfall in diagnosis (2005)

Article Deficient α-galactosidase A activity in plasma but no Fabry disease – a pitfall in diagnosis was published on November 1, 2005 in the journal Clinical Chemistry and Laboratory Medicine (CCLM) (volume 43, issue 11).
Production, composition, fatty acid profile and sensory analysis of goat milk in goats fed buriti oil (2017)

This study evaluated the effects of replacing ground corn with buriti oil ( L.) on feed intake and digestibility and on the production, composition, fatty acid profile and sensory characteristics of goat milk. A double Latin square (4 × 4) was used; eight goats were distributed in a completely randomized design. The square comprised four periods and four buriti oil concentration (0.00; 1.50; 3.00 and 4.50% of total DM) replacing corn. Intakes of DM, CP, NDF, ADF, non-fibrous carboydrates (NFC) and TDN were not affected by the replacement of corn with oil in the diet. However, lipids intake was increased ( < 0.01) by 100% in the diet of goats with 4.50% oil inclusion, as total DM. DM and CP digestibility were similar between the buriti oil concentrations. However, lipid digestibility increased linearly ( = 0.01) and may have contributed to a quadratic reduction in NDF digestibility ( = 0.01) and a linear reduction of NFC ( = 0.04) with buriti oil content in the goat feed. Goat milk production, corrected production and chemical composition were not influenced by the concentration of buriti oil replacement; however, milk fat concentration ( = 0.04) and feed efficiency ( < 0.01) increased linearly with the amount of buriti oil in the diet. There was a linear reduction on hypercholesterolemic SFA such as C12:0 ( < 0.01) and C14:0 ( < 0.01) as well as the atherogenic index (AI; < 0.01) with buriti oil inclusion in goat's diet. In contrast, the fatty acids C18:0 ( < 0.01) and C18:1 9 ( < 0.01) increased linearly in the milk of goats that were fed with buriti oil. However, CLA ( < 0.01) varied quadratically; the maximum production of 0.62 g/100 g of fat was observed when using 1.50% buriti oil. The sensory characteristics of the milk were not changed ( > 0.05) by the replacement of corn with buriti oil in the goats' diet. It is recommended to replace corn with buriti oil in goat feed by up to 4.5% of total DM, resulting in improved feed efficiency and milk fat without affecting production; this recommendation satisfies the minimum requirements of the industry and preserves the organoleptic characteristics of the milk and its acceptability for human consumption. In addition, buriti oil replacing ground corn by up to 4.5% DM in the diet of lactating goats decrease medium-chain SFA which are hypercholesterolemic and increase the concentrations of the C18:19, CLA and DFA in goat milk fat, helping to protect against cardiovascular disease.
Photoemission studies of the electronic structure of CdTe, CdSe, and CdS (1966)

Electronic structure photoemission studies of cadmium telluride, cadmium selenide, and cadmium sulfide
Trap filled limit of conducting organic materials (2002)

According to the approximate theory of transport in a conducting organic material containing exponential traps, ln J versus ln V plots are straight lines with slope l=TC/T, where TC is the characteristic temperature of the trap distribution. It is assumed in this theory that the concentration pt of trapped holes is much larger than the concentration p of free holes. Our experiments and recent literature results show that at high applied voltages the observed ln J versus ln V plots deviate from the straight lines and bend down. The numerical solution presented in this article shows that at high voltages the contribution of p to the space charge does not remain negligible. Calculated ln J versus ln V plots do bend down consistent with our experimental results. The current approaches the trap-filled limit asymptotically as the applied voltage approaches infinity.
Sonic Hedgehog-Induced Histone Deacetylase Activation Is Required for Cerebellar Granule Precursor Hyperplasia in Medulloblastoma (2013)

Medulloblastoma, the most common pediatric brain tumor, is thought to arise from deregulated proliferation of cerebellar granule precursor (CGP) cells. Sonic hedgehog (Shh) is the primary mitogen that regulates proliferation of CGP cells during the early stages of postnatal cerebellum development. Aberrant activation of Shh signaling during this time has been associated with hyperplasia of CGP cells and eventually may lead to the development of medulloblastoma. The molecular targets of Shh signaling involved in medulloblastoma formation are still not well-understood. Here, we show that Shh regulates sustained activation of histone deacetylases (HDACs) and that this activity is required for continued proliferation of CGP cells. Suppression of HDAC activity not only blocked the Shh-induced CGP proliferation in primary cell cultures, but also ameliorated aberrant CGP proliferation at the external germinal layer (EGL) in a medulloblastoma mouse model. Increased levels of mRNA and protein of several HDAC family members were found in medulloblastoma compared to wild type cerebellum suggesting that HDAC activity is required for the survival/progression of tumor cells. The identification of a role of HDACs in the early steps of medulloblastoma formation suggests there may be a therapeutic potential for HDAC inhibitors in this disease.