gebhart/patrepeval huggingface dataset:
GLUT4 molecules are recruited at random for insertion within the plasma membrane upon insulin stimulation (2009)

Glucose transporter 4 (GLUT4) is efficiently retained intracellularly. Here, we investigated the insulin-induced reduction of retention. While increasing insulin concentrations led to gradual increases in both the amount of recycling GLUT4 molecules and cell surface GLUT4 levels, the kinetics of the increase in time was independent of insulin concentration. To determine whether there are GLUT4 subpools that have a distinct insulin sensitivity, adipocytes were consecutively stimulated twice with a low concentration of insulin while recycling GLUT4 molecules were continuously labeled. This revealed that not the same pool of GLUT4 molecules was mobilized twice and thus that upon insulin stimulation, GLUT4 is likely to be recruited at random for insertion within the plasma membrane.
Sternal wound infection: our experience with 200 cases. (1994)

More than 200 patients with sternal wound infections have been treated in the Plastic Surgery Department of our Medical Center over the years 1984-1993. Most of these were referrals from other hospitals. In recent years, the cases have become more severe, partially due to the fact that cardiac surgeons tend to operate older and sicker patients more readily than they previously did. 80% of these were post coronary bypass surgery, and the others heart and heart-lung transplants, repair of congenital heart anomalies, valve replacements etc. Several of the cases were cardiac surgery re-do's. Risk factors for developing this complication, such as diabetes, obesity, technical errors of sternal incision, prolonged intubation, the use of aortic balloon, etc. will be discussed. Many of our earlier patients had chronic fistulae following conservative therapy with old treatment modalities. In recent years, patients are usually referred at the acute stage. Most patients undergo removal of sternum and ribs. Previously, reconstruction included mainly transfer of the rectus ahdominis muscle, whereas lately the pectoralis muscles is utilized. Omentum was used in only one case. The importance of pre-operative imaging procedures has been thoroughly studied in our series. Especially important is the definition of the extent of the infection, and localization of foreign bodies causing chronic infections, such as suture material, epicardial electrodes etc. A change in infectants has also been noticed. In the first half of the study period, Pseudomonas aeruginosa comprised at least 40%.(ABSTRACT TRUNCATED AT 250 WORDS)
CHAPTER 4: Minor Constituents (2010)

Cereals & Grains Association is a nonprofit organization dedicated to advancing the knowledge and understanding of cereal grain science through research leadership, education, superior technical service, and advocacy.
Effect of Time to Operative Intervention on Motility Outcomes Following Orbital Floor Fracture Repair in Children (2017)

Our exploratory study suggests that surgical reduction of inferior rectus entrapment in pediatric orbital floor fractures within 24 hours from the time of injury shows an improved, but nonstatistically significant, likelihood of recovery in motility deficits with earlier surgical intervention.
Active complex event processing (2010)

Our analysis of many real-world event based applications has revealed that existing Complex Event Processing technology (CEP), while effective for efficient pattern matching on event stream, is limited in its capability of reacting in realtime to opportunities and risks detected or environmental changes. We are the first to tackle this problem by providing active rule support embedded directly within the CEP engine, henceforth called Active Complex Event Processing technology, or short, Active CEP. We design the Active CEP model and associated rule language that allows rules to be triggered by CEP system state changes and correctly executed during the continuous query process. Moreover we design an Active CEP infrastructure, that integrates the active rule component into the CEP kernel, allowing fine-grained and optimized rule processing. We demonstrate the power of Active CEP by applying it to the development of a collaborative project with UMass Medical School, which detects potential threads of infection and reminds healthcare workers to perform hygiene precautions in real-time.
Cytotoxic Coumarins from the Aerial Parts of<i>Tordylium apulum</i>and their Effects on a Non-Small-Cell Bronchial Carcinoma Cell Line (1998)

Seven coumarins were isolated from the aerial parts of Tordylium apulum; their structures were established by spectroscopic means. All compounds were tested in vitro for their cytotoxicity against two cell line systems. The antiproliferative effects for three of them were studied at the level of the cell cycle in asynchronous cells of the NSCLC-N6 line with a flow cytometry apparatus.
Effect of 2% dimethyl sulfoxide on the mitogenic properties of epidermal growth factor and hepatocyte growth factor in primary hepatocyte culture (1991)

Two percent dimethyl sulfoxide (DMSO) reversibly inhibited DNA synthesis in primary rat hepatocyte cultures maintained with epidermal growth factor (EGF) or hepatocyte growth factor (HGF). These data suggest that, in vitro, DMSO is a non-specific inhibitor of hepatocyte proliferation, regardless of the stimulating mitogen. In addition, removal of DMSO from mitogen-free cultures resulted in an increase in DNA synthesis. Protein synthesis gradually but irreversibly declined in all cultures after DMSO removal. The relevance of these findings to regulation of hepatocyte growth is discussed.
Jean-Pierre Royer, Histoire de la justice en France, de la monarchie absolue à la République (1995)

Bart Jean. Jean-Pierre Royer, Histoire de la justice en France, de la monarchie absolue à la République. In: Annales historiques de la Révolution française, n°302, 1995. pp. 653-654.
Carbon and light limitation in mass algal culture (1980)

The carbon limited kinetic responses of various fast growing algal species have been summarized. These results suggest that the growth responses of many algae used in mass culture may best be represented as a Monod fit of the specific growth rate (..mu..) to the free carbon dioxide concentration (CO/sub 2//sub f/). The environmental modifiers of primary importance appear to be light levels, temperature and the ionic strength of the growth media. The various mathematical models describing the algal biological response to limitng CO/sub 2//sub f/ concentration, the carbonate equilibrium chemistry and the physical configration of a flow-through microbial culture are combined to yield equations which predict the pH, total carbon concentration (C/sub T/) and algal cell concentration of a continuous alga culture, given a ..mu../sub max/ and K/sub SCO2/ for the alga of interest. This model is further used to illustrate the under-utilization of inorganic carbon in mass algal cultures in which the pH is uncontrolled. One method of pH control in such cultures involves the utilization of CO/sub 2/ supply from bacterial degradation of waste organics in the influent culture medium. In such a situation both the culture pH and algal cell production will often be governed by eithermore » carbon or light limitation depending primarily on the influent BOD loading, detention time and culture depth. In spite of the obvious over-simplification of considering only light and carbon limits in describing the behavior of mass algal culture, comparisons to actual field data suggest that these two parameters will be of paramount importance in controlling net algal cell production rates.« less
Comparison of penalties resulting from first-order and all-order polarization mode dispersion distortions in optical fiber transmission systems (2003)

We compare the eye-opening penalty from a first-order polarization mode dispersion (PMD) model with that from an all-order PMD model in optical fiber transmission systems. Evaluating the performance by taking into account only first-order PMD produces a good approximation of the true eye-opening penalty of uncompensated systems when the penalty is low. However, when the penalties are high, this model overestimates the penalty for outage probabilities in the range of interest for systems designers, which is typically approximately 10(-5) to 10(-6).
Perceiving and describing motion events (2003)

According to Hurford, PREDICATE (x) is correlated with deictic object variables during event perception. This claim is inconsistent with some core literature on the perception of motion events. We point out that the perception of events involves the activation of the modal properties and amodal properties of underlying event structure, for which Hurford's target article fails to account.
Use of conformal maps to model the voltammetric response of collector-generator double-band electrodes (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of conformal maps to model the voltammetric response of collector-generator double-band electrodesBruno. Fosset, Christian A. Amatore, Joan E. Bartelt, Adrian C. Michael, and R. Mark. WightmanCite this: Anal. Chem. 1991, 63, 4, 306–314Publication Date (Print):February 15, 1991Publication History Published online1 May 2002Published inissue 15 February 1991https://doi.org/10.1021/ac00004a003Request reuse permissionsArticle Views272Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
cDNA heterogeneity suggests structural variants related to the high-affinity IgE receptor. (1988)

The high-affinity IgE receptor present on mast cells and basophils is responsible for the IgE-mediated activation of these cells. The current model for this receptor depicts a four-subunit structure, alpha beta gamma 2. A cDNA for the alpha subunit was recently cloned and predicts a structure consisting of two homologous extracellular domains, a transmembrane segment, and a cytoplasmic tail. Using a synthetic oligonucleotide corresponding to the amino-terminal sequence of the alpha subunit, we identified a number of cDNA clones from a rat basophilic leukemia cell cDNA library. Nucleotide sequencing established four different forms of cDNA: one is nearly identical to the published cDNA; the second differs from the first in the 5' untranslated sequence; the other two forms use either one or the other of the 5'-end sequences as above and lack 163 base pairs in the region coding for the second extracellular domain. RNase protection analysis with radioactive RNA probes established the heterogeneity of rat basophilic leukemia cell mRNA with regard to both the 5' and the internal sequences. Our results suggest the existence of at least four different protein forms related to the alpha subunit of the high-affinity IgE receptor.
Photonic Quasi-crystal enhanced Organic Light Emitting Diodes (2010)

In this paper we discuss theoretical modelling methods for design of photonic crystal and photonic quasi-crystal (PQC) Organic –Light Emitting Diodes, and apply them to the analysis of the extraction enhancement performance, and extraction beam shaping profile of bottom emitting organic LED structures incorporating photonic crystal structures within the layer stack. We first discuss trapping mechanisms within an OLED stack and investigate the effect of position of the patterning within the OLED layer structure, to derive the optimal position for maximum extraction efficiency and ease of fabrication. We investigate performance improvement associated with top and rear side patterning of the glass cover slip, effect of refractive index contrast for the backfill material and effect of lattice pitch. In addition, we examine the physical mechanisms giving rise to performance improvement in each case, examining the interplay and relative contributions to performance improvement such as effective index reduction effects which alter conditions for total internal reflection at the device air interface, and photonic crystal scattering effects which give rise to radically improved extraction performance.
Obliteration Index: a simple non-invasive tool for the assessment of peripheral vascular disease in chronic kidney disease (2009)

The OI method has now been introduced into routine use in the authors' department. Based on over 1,500 OI evaluations performed so far, it can be recommended as a simple, noninvasive, bedside tool for diagnosis of early as well as advanced PAD.
Light Weight Container For Large Caliber Munitions - Phase II. (1998)

Abstract : The Army currently uses a heavy steel rectangular container to store and transport large caliber munitions. This project is focused on designing and testing a new, efficient, light weight container for this purpose. The original metal container was designed to hold 2 munitions and weighed in excess of 100 pounds including the weight of the munitions. The new container, referred to as a monopack due to its design to hold only one munition, is cylindrical in shape and 30.5 inches long and weighs approximately 7 lbs. The preliminary design of the monopack during the first phase of the project incorporated lightweight composite materials for the body and a lightweight damage-resistant polymer for the end caps. A large amount of the Phase I effort was dedicated to prototype testing. For instance, moisture absorption tests, impact tests, and full scale impact drop tests were onducted on these composite cylinder test articles to check for penetration and damage resistance of the container and its endcaps. second phase effort was designed to follow up on the recommendations that were proposed after the results of the Phase I tests had been analyzed. Investigation of a higher failure strain polymer for the end caps was the most critical issue going into the second phase of this project. Three possible candidates were chosen based upon the shortcomings of the material that was used in Phase I and several discussions with materials experts about the material properties that were required to surpass the high impact drop tests. Also the thread design and the gasket seal of the top cap were modified such that the top cap could be screwed on with fewer turns an he gasket would seal the container without being damaged during an inadvertent impact. The details of the modifications, fabrication, and testing of the container for the Phase II effort are described in this report.
Prostate carcinoma screening in the county of Tyrol, Austria (1997)

These data suggest that PSA-based screening increases the detection rate of clinically significant and organ-confined tumors. Percent free PSA and PSA transitional zone density provide an additional diagnostic benefit over total PSA.
Sedimentological and palynological constraints on the basal Triassic sequence in Central Switzerland (2007)

In Central Switzerland, Mesozoic sedimentation began after erosion and peneplainisation of the Hercynian relief and late Paleozoic continental deposition in SW-NE striking pull-apart basins. The first Triassic sedimentary sequence overlaying a weathered crystalline basement consists of a relatively thin (<10 m), lithologically highly variable unit with coarse-grained siliciclastic deposits at the base, grading into a mixed sandstone/shale-dolomite sequence followed by well-bedded dolomites with chert nodules. Sedimentary texture analyses and petrological investigations revealed four different sedimentary units starting at the base with a regolith unit that represents the weathered crystalline basement. It is overlain by terrestrial plain deposits, followed by mixed siliciclastic-carbonaceous sediments and a sequence of dolomites, deposited between the supralittoral and eulittoral zones of a tidal flat (Mels-Formation), and the eulittoral to sublittoral zones of a carbonate tidal flat environment (Röti-Dolomit), respectively. Palynological data from four localities in Central Switzerland indicate a heterochronous early Anisian age (Aegean – Bithynian/Pelsonian) for the supra- to eulittoral mixed siliciclastic-carbonaceous sediments. These new biostratigraphic ages suggest that the first Triassic marine transgression in Central Switzerland is time equivalent with those of the basal Wellendolomit in Northern Switzerland but slightly older than in the Germanic Basin. Consequently, Central Switzerland was located at this time at the northern shoreline of the Tethys and not on the southern limit of the Germanic Basin.
Leishmania parasites and their ploys to disrupt macrophage activation (2000)

Leishmania are intracellular protozoan parasites of macrophages. At the cellular level, the disease leishmaniasis involves the invasion of tissue macrophages by the parasite, the avoidance of cellular killing mechanisms, and the subsequent intracellular replication of parasites, with the eventual spread of the organisms to adjacent macrophages. This paper describes the process by which Leishmania organisms invade macrophages, with an overview of some of the molecules involved in this process; the mechanisms available to macrophages that have the potential to restrict the growth of Leishmania within them; and the ways that Leishmania and Leishmania-derived molecules can modulate macrophage functions and circumvent leukocyte antimicrobial responses.
Determination of intracellular calcium in vivo via fluorine-19 nuclear magnetic resonance spectroscopy (1995)

Fluorine-19-nuclear magnetic resonance (19F-NMR) spectroscopic detection of the NMR-active Ca2+ indicator 5-fluoro-1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (5F-BAPTA) is one method for measuring cytosolic free Ca2+ concentration ([Ca2+]i) and has been used previously to measure [Ca2+]i in isolated cells and perfused organs. The aim of the present investigation was to demonstrate the feasibility of determining [Ca2+]i in vivo and in situ using 19F-NMR and 5F-BAPTA. Experiments were performed on male Sprague-Dawley rats with a surface-coil antenna employed for NMR interrogation. The Ca2+ indicator, 5F-BAPTA, was infused either intravenously (kidney, spleen) or intraventricularly (brain) as a 100 mg/ml solution of the cell-permeant acetoxymethyl ester (5F-BAPTA-AM) in dimethyl sulfoxide. Rats tolerated intravenous infusion without evident change in mean arterial blood pressure. In all tissues examined, kidney, spleen, and brain, [Ca2+]i was approximately 200 nM. To our knowledge, these results represent the first in vivo and in situ determinations of [Ca2+]i employing 19F-NMR.
Nonequilibrium Adhesion Patterns at Lipid Bilayer Junctions (2003)

With lipid bilayer−bilayer junctions in mind as model systems for the study of cell−cell junctions, we have examined adhesion between simple lipid membranes using fluorescence resonance energy transfer (FRET) and fluorescence interference contrast microscopy (FLIC) to map the interfacial topography. The contact can take the form of uniform adhesion, with an intermembrane separation of nanometers, or nonuniform adhesion, in which blisters hundreds of nanometers in height coexist with tight adhesion zones. We find that blisters can result as a consequence of rapid interbilayer contact induced by osmotic shock. We develop a model for the formation and stabilization of the blisters, confirming that these phenomena are governed mainly by hydrodynamic flow in the intermembrane space.
On Spatial Conjunction as Second-Order Logic (2004)

Spatial conjunction is a powerful construct for reasoning about dynamically allocated data structures, as well as concurrent, distributed and mobile computation. While researchers have identified many uses of spatial conjunction, its precise expressive power compared to traditional logical constructs was not previously known. In this paper we establish the expressive power of spatial conjunction. We construct an embedding from first-order logic with spatial conjunction into second-order logic, and more surprisingly, an embedding from full second order logic into first-order logic with spatial conjunction. These embeddings show that the satisfiability of formulas in first-order logic with spatial conjunction is equivalent to the satisfiability of formulas in second-order logic. These results explain the great expressive power of spatial conjunction and can be used to show that adding unrestricted spatial conjunction to a decidable logic leads to an undecidable logic. As one example, we show that adding unrestricted spatial conjunction to two-variable logic leads to undecidability. On the side of decidability, the embedding into second-order logic immediately implies the decidability of first-order logic with a form of spatial conjunction over trees. The embedding into spatial conjunction also has useful consequences: because a restricted form of spatial conjunction in two-variable logic preserves decidability, we obtain that a correspondingly restricted form of second-order quantification in two-variable logic is decidable. The resulting language generalizes the first-order theory of boolean algebra over sets and is useful in reasoning about the contents of data structures in object-oriented languages.
DMD-based 3D micro-manufacturing (2010)

The development of the Digital Micromirror Device (DMD) by Texas Instruments has made a significant breakthrough in 3D micro-manufacturing, and in particular, in the area of additive layer-based manufacturing. One area of particular interest for using DMD technology is microstereolithography; a technology that builds 3D shapes through successive photopolymerization of individual thin 2D layers that are stacked vertically. A DMD-based projection microstereolithography system and a robust micro-manufacturing process have been developed. This system and various micro-fabricated 3D structures with features on the order of 10 microns, including recent advancements in multimaterial micro-fabrication, will be presented and described.