gebhart/patrepeval huggingface dataset:
Effects of bFGF incorporated into a gelatin sheet on wound healing (2005)

Basic fibroblast growth factor (bFGF) is well known to promote the proliferation of almost all cells associated with wound healing. However, as the activation duration of bFGF is very short in vivo, we incorporated bFGF into an acidic gelatin hydrogel and studied the sustained release of bFGF in vivo. In addition, we investigated the effects of the acidic gelatin sheet containing bFGF on wound healing. To distinguish wound contraction from neoepithelialization, we measured both the wound area and neoepithelium length. Other histological parameters such as thickness of granulation tissue and number of capillaries were also determined as indices of wound healing. Fibrous tissue was assessed using an Elastica van Gieson and Azan stain. A skin defect (1.5 x 1.5 cm) of full thickness was created on the back of each test mouse and the wound was covered with an acidic gelatin hydrogel, referred to as a gelatin sheet in this study (2 x 2 cm), with bFGF (100 microg/site) (A) or without bFGF (B). 1, 2, 3, 5, 7 and 14 days after covering, mice were killed and an enzyme-linked immunosorbent assay (ELISA) was performed to estimate the concentration of bFGF in the plasma. In another experiment, each wound was covered with (A), (B) or a hydrogel dressing (control group, C) and the wound area was measured 1 or 2 weeks postoperatively with a computer planimeter. The histological parameters, as mentioned above, were assessed using a light microscope. Sustained release of bFGF from the gelatin sheet was observed and the gelatin sheet containing bFGF promoted neoepithelialization, granulation, neovascularization and wound closure. This gelatin sheet containing bFGF was concluded to be effective for wound healing and promising for clinical use.
Endothelial dysfunction in aging animals: the role of poly(ADP‐ribose) polymerase activation (2002)

Recent work has demonstrated the production of reactive oxygen and nitrogen species in the vasculature of aging animals. Oxidant induced cell injury triggers the activation of nuclear enzyme poly(ADP ribose) polymerase (PARP) leading to endothelial dysfunction in various pathophysiological conditions (reperfusion, shock, diabetes). Here we studied whether the loss of endothelial function in aging rats is dependent upon the PARP pathway within the vasculature. Young (3 months-old) and aging (22 months-old) Wistar rats were treated for 2 months with vehicle or the PARP inhibitor PJ34. In the vehicle-treated aging animals there was a significant loss of endothelial function, as measured by the relaxant responsiveness of vascular rings to acetylcholine. Treatment with PJ34, a potent PARP inhibitor, restored normal endothelial function. There was no impairment of the contractile function and endothelium-independent vasodilatation in aging rats. Furthermore, we found no deterioration in the myocardial contractile function in aging animals. Thus, intraendothelial PARP activation may contribute to endothelial dysfunction associated with aging.
Quantitation of Neuropeptides in <i>Cpe</i><i><sup>f</sup></i><i><sup>at</sup></i><i>/Cpe</i><i><sup>f</sup></i><i><sup>at </sup></i>Mice Using Differential Isotopic Tags and Mass Spectrometry (2002)

Neuroendocrine peptides play important roles as intercellular messengers. We previously developed a technique to isolate and identify a large number of neuroendocrine peptides from Cpe(fat)/Cpe(fat) mice (Che, F.; et al. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 9971-6); these mice lack carboxypeptidase E activity and this defect causes an accumulation of neuropeptide intermediates that contain C-terminal Lys or Arg residues (Naggert, J. K.; et al. Nat. Genet. 1995, 10, 135-42). In the present study, we have developed a differential isotopic-labeling technique that can be used to quantitate changes in neuropeptide levels in Cpe(fat)/Cpe(fat) mouse tissues. Samples are treated with either the H6 or the D6 form of acetic anhydride, peptides that contain C-terminal basic amino acids are isolated by affinity chromatography on anhydrotrypsin agarose, and the isolated peptides are analyzed by mass spectrometry. Measurement of the regulation of pituitary peptides in response to dehydration showed a decrease in vasopressin. The general method described in this report should be widely applicable to a large number of neuroendocrine peptides, known and novel, in a variety of regulatory paradigms.
Reaction Model for the Fluorination of Uranium and Plutonium Compounds in Fluidized-Bed Reactors (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction Model for the Fluorination of Uranium and Plutonium Compounds in Fluidized-Bed ReactorsLouis J. Anastasia, Peter G. Alfredson, and Martin J. SteindlerCite this: Ind. Eng. Chem. Process Des. Dev. 1971, 10, 2, 150–157Publication Date (Print):April 1, 1971Publication History Published online1 May 2002Published inissue 1 April 1971https://pubs.acs.org/doi/10.1021/i260038a002https://doi.org/10.1021/i260038a002research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Association of branched nucleic acids: structural and physicochemical analysis of antiparallel T.cntdot.AT triple-helical DNA (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAssociation of branched nucleic acids: structural and physicochemical analysis of antiparallel T.cntdot.AT triple-helical DNARobert H. E. Hudson, Andre H. Uddin, and Masad J. DamhaCite this: J. Am. Chem. Soc. 1995, 117, 50, 12470–12477Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/ja00155a011https://doi.org/10.1021/ja00155a011research-articleACS PublicationsRequest reuse permissionsArticle Views144Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
BACH2 (BTB and CNC homology 1, basic leucine zipper transcription factor 2) (2011)

Review on BACH2 (BTB and CNC homology 1, basic leucine zipper transcription factor 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Weldalite (trademark) 049 (Al 2095-T8): Anisotropy Effects at Cryogenic Conditions (1993)

Tensile, fracture, and FCGR testing was performed on a plate of the aluminum-lithium alloy Weldalite(TM) 049 (Al 2095-T8) over a temperature range from ambient to liquid helium (4K) conditions. Properties were developed on specimens removed from various orientations within a 12.7 mm (1/2 in) nominal thick plate to characterize anisotropy with respect to strength and toughness. Strength and FCGR properties are compared to the conventional aluminum alloy 2219-T87, developed for similar cryogenic applications. Results indicate a high degree of anisotropy with respect to strength and ductility, with the lowest strength/highest ductility occurring at 45-60 deg from the rolling direction. Decreases in test temperature led to higher strengths and similar anisotropic behavior, with little or no change in ductility. Fracture toughness measurements did not reveal any significant orientation effects, with toughness levels insensitive to the cryogenic temperatures examined. It was not possible to develop valid FCGR data on C(T) samples oriented in either the T-L or T-L plate directions due to out-of-plane cracking. Constant amplitude FCGR data generated on 45 deg oriented samples are comparable with reference data on similar Weldalite material for the T-L and L-T directions, though a slight degree of anisotropy appears to exist at lower values of Delta K. FCGR data obtained at liquid nitrogen and liquid helium test conditions were identical and only slightly lower than similar data developed under ambient conditions. Weldalite(TM) 049, Fracture toughness, Cryogenic, Aluminum-lithium, Tensile, 2219, 2095, Fatigue crack growth
Testing OSI protocols at the national bureau of standards (1983)

The Institute for Computer Sciences and Technology at the National Bureau of Standards has developed an architecture for testing implementations of OSI protocols, to establish conformance with the appropriate Federal Information Processing Standards. This paper gives a justification for specific design choices made, describes architectural elements, and gives an example of a test language used to drive the test system. Some examples are given to indicate the practical utility of this system, demonstrated by over 18 months of testing experience.
ABRF 2015: Outstanding Scientific Poster Awards (2015)

With the continuing mission of providing significant educational opportunities to the ABRF membership, the Education Committee (EdComm) has a proud heritage of overseeing the Water’s Research Poster competition for the annual meeting. The competition is open to all and includes scientific reports from academia as well as cutting-edge research from core facilities and corporate research and development groups. The goal of offering the awards is to elicit the highest level of information on techniques, applications, and technologies and share knowledge pertinent to further excellence in core facility services.
Hole-Induced Threshold Voltage Shift Under Reverse-Bias Stress in E-Mode GaN MIS-FET (2018)

Under reverse-bias stress (i.e., OFF-state stress with V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GS</sub> <; V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> ) with high drain voltage, ultraviolet (UV) illumination and larger negative gate bias are found to accelerate the positive shift in threshold voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> ) of enhancement-mode GaN MIS-FETs with fully recessed gate. These results suggest a hole-induced degradation mechanism. In the absence of UV illumination, holes could be generated by impact ionization in the high electric-field region, which is initiated by electrons injected from the source through the buffer layer. With a larger negative gate bias, more holes will flow to the gate side and pass through the silicon nitride (SiN <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> ) gate dielectric, as SiN <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> does not present any energy barrier to holes. The enhanced hole transport through the dielectric under large negative gate bias could accelerate new defects generation and therefore result in the larger positive threshold voltage shifts.
A low-power CMOS Gm-C filter for wireless receiver applications with on-chip automatic tuning system (2006)

In this paper, a fourth-order, 3.5-MHz, low-pass elliptic Gm-C filter employing low-noise, low-voltage transconductance amplifiers is presented. A new technique to enhance the linearity of the Gm-C filter is proposed. Furthermore, the nonlinear behavior of the filter caused by nonlinear behavior of transconductors with determined input amplitude is discussed. HSpice simulation results of the 1.8-V filter in a 0.18 /spl mu/m CMOS process show a THD of less than -44dB for 0.6V/sub pp/ input signal and an input-referred noise of less than 45 nV//spl radic/Hz in worst case. The current consumption of each OTA is 1.5-mA.
Optical instrument to measure the mass concentration and size distribution of smoke particles. Final report, 8 May 1997--7 February 1998 (1997)

This proposal describes the development of a system to measure in-situ and in real-time, the size distribution and mass concentration of soot particles in turbojet exhausts. The proposed system will work in-situ in highly turbulent environments. The total signal will yield soot mass concentration while the time-resolved signal will yield particle size. Its potentially compact size and large dynamic measurement range will give the system broad market potential in a variety of industries attempting to measure and suppress particle pollution. The Phase 1 work will include developing an analytical model to derive soot mass concentration and particle size from the signal. A breadboard will be built to conduct proof-of-concept experiments, and the preliminary design for a field system will be produced. The proposed system will be particularly valuable to the Air Force to measure soot in engine test facilities which are characterized by high vibration and noise levels.
CSR SHIELDING EXPERIMENT (2011)

It is well known that the emission of coherent synchrotron radiation (CSR) in a dipole magnets leads to increase in beam energy spread and emittance. At the Brookhaven National Laboratory Accelerator Test Facility (ATF) we study the suppression of CSR emission affect on electron beam in a dipole magnet by two vertically spaced conducting plates. The gap between the plates is controlled by four actuators and could be varied from 0 to 14 mm. Our experimental results show that closing the plates significantly reduces both the beam energy loss and CSRinduced beam energy spread. In this paper we present selected results of the experiment and compare then with rigorous analytical theory.
Stopband Correction of the AGS Booster 9th Normal Sextupole Correction Test (1993)

The aim of this study is to test of 9th normal sextupole correction to reduce the residual loss of the half-integer resonances, 2Qx=9 and 2Qy=9.
Strain-resolved microbiome sequencing reveals mobile elements that drive bacterial competition on a clinical timescale (2017)

Abstract Although shotgun short-read sequencing has facilitated the study of strain-level architecture within complex microbial communities, existing metagenomic approaches often cannot capture structural differences between closely related co-occurring strains. Recent methods, which employ read cloud sequencing and specialized assembly techniques, provide significantly improved genome drafts and show potential to capture these strain-level differences. Here, we apply this read cloud metagenomic approach to longitudinal stool samples from a patient undergoing hematopoietic cell transplantation. The patient’s microbiome is profoundly disrupted and is eventually dominated by Bacteroides caccae . Comparative analysis of B. caccae genomes obtained using read cloud sequencing together with metagenomic RNA sequencing allows us to predict that particular mobile element integrations result in increased antibiotic resistance, which we further support using in vitro antibiotic susceptibility testing. Thus, we find read cloud sequencing to be useful in identifying strain-level differences that underlie differential fitness.
Investigation of the phase separations and the local electronic structures of Zn1−xTxO (T=Mn, Fe, Co) magnetic semiconductors using synchrotron radiation (2006)

The spatial chemical distributions of doped T ions and their local electronic structures in Zn1−xTxO (T=Mn, Fe, Co; x⩽0.1) have been investigated simultaneously by using scanning photoelectron microscopy (SPEM), photoemission spectroscopy (PES), and soft-x-ray absorption spectroscopy (XAS). The measured SPEM images for Zn1−xTxO single crystals reveal the uniform chemical distributions of T ions, indicating the homogeneous substitution of T ions for Zn sites. The T2p XAS spectra of Zn1−xTxO show that Mn and Co ions are in the divalent states, while Fe ions are in the Fe2+–Fe3+ mixed-valent states. The valence-band PES study of Zn1−xTxO (T=Mn, Fe, Co) shows that T3d states lie near the top of the O 2p valence bands. Only ferromagnetic Zn1−xTxO shows a significantly large Fe 3d photoemission intensity near EF, in contrast to the negligible Mn and Co 3d photoemission intensities near EF in nonferromagnetic Zn1−xTxO (T=Mn, Co), suggesting that the high carrier density is important in determining the ferromagnetic behavior of Zn1−xTxO.
Leptin contributes to the protection of human leukemic cells from cisplatinum cytoxicity. (2000)

Leptin (ob gene) and its cognate receptor (obr) are relevant for fat metabolism. Obr shares homology with the IL-6 signal transducer gp130 and is expressed in hematopoietic cells. Since cytokines and growth factors regulate both hematopoiesis and response to chemotherapy, we tested the hypothesis of whether leptin protects leukemic cells from cytotoxicity of cisplatinum. Antisense phosphorothioate oligodeoxynucleotides (ODNs) and antisense peptide nucleic acids (PNAs) complementary to the obr gene were first tested for their growth inhibitory activity in obr expressing leukemic cells. Liposome-mediated transfection of ODNs (1-2 microM) or PNAs (0.01-1 microM) inhibited growth up to 50%. Combination treatments of cisplatinum and 0.01 microM PNA reduced growth more than cisplatinum alone. Vice versa, recombinant human leptin (rhL) diminished cisplatinum-induced growth inhibition. Finally, we investigated whether rhL affects cisplatinum-induced DNA damage and repair in the housekeeping gene beta-actin by means of real time TaqMan polymerase chain reaction. RhL reduced DNA damage and increased DNA repair. The effects are, however, modest and leptin is probably not the only player in the armory of growth factors which affect drug resistance.
Squeeze-film damping of flexible microcantilevers at low ambient pressures: theory and experiment (2009)

An improved theoretical approach is proposed to predict the dynamic behavior of long, slender and flexible microcantilevers affected by squeeze-film damping at low ambient pressures. Our approach extends recent continuum gas damping models (Veijola 2004 J. Micromech. Microeng. 14 1109-18, Gallis and Torczynski 2004 J. Microelectromech. Syst. 13 653-9), which were originally derived for a rigid oscillating plate near a wall, to flexible microcantilevers for calculating and predicting squeeze-film damping ratios of higher order bending modes at reduced ambient pressures. Theoretical frequency response functions are derived for a flexible microcantilever beam excited both inertially and via external forcing. Experiments performed carefully at controlled gas pressures are used to validate our theoretical approach over five orders of the Knudsen number. In addition, we investigate the relative importance of theoretical assumptions made in the Reynolds-equation-based approach for flexible microelectromechanical systems.
Intestinal Signaling of Proteins and Digestion-Derived Products Relevant to Satiety (2018)

Luminal nutrients stimulate enteroendocrine cells through the activation of specific receptors to release hormones that inhibit appetite and promote glucose homeostasis. While food protein is the macronutrient with the highest effect on satiety, the signaling on the protein digestion products at the gut is poorly understood. This perspective aims to highlight the existing gaps in the study of protein digestion products as signaling molecules in gastrointestinal enteroendocrine cells. Because dietary protein digestion can be modulated by the technological processes applied to food, it is possible to target gut receptors to control food intake by formulating specific food ingredients or protein preloads.
Disseminated Infection Due to Acremonium Species in a Patient with Addison's Disease (1993)

Journal Article Disseminated Infection Due to Acremonium Species in a Patient with Addison's Disease Get access William R. Jeffrey, William R. Jeffrey Sections of Infectious Diseases and Internal Medicine, Marshall University School of Medicine, Huntington, West Virginia Search for other works by this author on: Oxford Academic PubMed Google Scholar Jaime E. Hernandez, Jaime E. Hernandez Sections of Infectious Diseases and Internal Medicine, Marshall University School of Medicine, Huntington, West Virginia Search for other works by this author on: Oxford Academic PubMed Google Scholar Antonio L. Zarraga, Antonio L. Zarraga Sections of Infectious Diseases and Internal Medicine, Marshall University School of Medicine, Huntington, West Virginia Search for other works by this author on: Oxford Academic PubMed Google Scholar Gretchen E. Oley, Gretchen E. Oley Sections of Infectious Diseases and Internal Medicine, Marshall University School of Medicine, Huntington, West Virginia Search for other works by this author on: Oxford Academic PubMed Google Scholar Lynn W. Kitchen Lynn W. Kitchen Sections of Infectious Diseases and Internal Medicine, Marshall University School of Medicine, Huntington, West Virginia Correspondence: Dr. Lynn W. Kitchen, Section of Infectious Diseases, Marshall University School of Medicine, 180 16th Avenue, Huntington, West Virginia 25703. Search for other works by this author on: Oxford Academic PubMed Google Scholar Clinical Infectious Diseases, Volume 16, Issue 1, January 1993, Page 170, https://doi.org/10.1093/clinids/16.1.170 Published: 01 January 1993
VLSI technologies for artificial neural networks (1989)

VLSI systems, basic integrated circuits, and silicon technologies are discussed. Novel circuit and design principles that provide a foundation for the implementation of a wide variety of neural network models in silicon are described. The key issues for a successful integration of neural systems are identified. The realization of algorithms in silicon is examined. Special-purpose hardware for carrying out the activation and transfer function and for the connection elements is discussed. A brief overview of the current silicon technologies is provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Ultrafast observation of lattice dynamics in laser-irradiated gold foils (2017)

We have observed the lattice expansion before the onset of compression in an optical-laser-driven target, using diffraction of femtosecond X-ray beams generated by the SPring-8 Angstrom Compact Free-electron Laser. The change in diffraction angle provides a direct measure of the lattice spacing, allowing the density to be calculated with a precision of ±1%. From the known equation of state relations, this allows an estimation of the temperature responsible for the expansion as &lt;1000 K. The subsequent ablation-driven compression was observed with a clear rise in density at later times. This demonstrates the feasibility of studying the dynamics of preheating and shock formation with unprecedented detail.