gebhart/patrepeval huggingface dataset:
Reduction of r-hirudin induced bleeding in pigs by the administration of von Willebrand factor (1996)

To prevent r-hirudin induced excess bleeding an animal model was established in pigs for the investigation of an anti-bleeding strategy. We used the Simplate® device to monitor skin bleeding time (SBT) at the inner site of the ear. r-Hirudin infused in a dose of 0.3 mag per h induced a prominent increase of SBT. The aim of our studies was to reverse r-hirudin induced bleeding by enhancing platelet adhesion to the endothelium via the administration of von Willebrand Factor (vWF). Pigs were treated with vWF containing solutions (Haemate® and a vWF-concentrate) at 3h after the start of the r-hirudin infusion. Both compounds suppressed SBT 1h after administration and significantly prevented bleeding until the termination of the experiment. SBT values (given in times of baseline) in the placebo group were 3.32 ± 0.9, 1.51 ± 0.14 in the Haemate® and 1.85 ± 0.42 in the vWF concentrate group (P = 0.008 or 0.032, in a two-sided Kruskall-Wallis-test). Coagulation parameters (aPTT, PT) were unaltered by the treatment, as were the r-hirudin plasma levels suggesting that vWF is not an antidote in its strict sense. It is concluded that vWF reverses bleeding without altering the anticoagulant effect of r-hirudin. Addition of 20 mg/kg per h aspirin resulted in a further increase of SBT. Aspirin, moreover, suppressed platelet aggregation but did not alter platelet counts. In a further study, bleeding induced by r-hirudin and aspirin was antagonized by Haemate® (66 Ukg i.v. bolus + 187 Ukg per h for 2 h infusion) and a significant reduction of bleeding time occurred.
A Pillared-Layer Coordination Polymer Network Displaying Hysteretic Sorption: [Cu2(pzdc)2(dpyg)]n (pzdc= Pyrazine-2,3-dicarboxylate; dpyg=1,2-Di(4-pyridyl)glycol) (2002)

Ein hystereseförmiges Adsorptions-/Desorptionsprofil (rechts) und die Umwandlung der Kristallstruktur bei Einwirkung von H2O- oder MeOH-Dampf unter Druck wird bei der Titelverbindung beobachtet, die aus übereinander gestapelten Säulen aufgebaut ist (links).
Microstructured Channel Waveguide Lasers in KY(WO4)2:Gd3+,Lu3+,Yb3+ (2010)

Laser operation was achieved in microstructured channel waveguides of KY(WO4)2:Gd3+, Lu3+, Yb3+, resulting in a threshold of only 5 mW, a slope efficiency of 62% versus launched pump power, and 76 mW output power.
ANALYSE DES SIGNAUX DE RONFLEMENT (1990)

Snoring is a phenomenon which may disturb both the sociallife and health of a patient. Acoustical analysis of snoring can beuse to identify some clinical problems and we present a study of thisand some preliminary results.
Layer-dependent spin-polarized 3<i>p</i>core-level photoemission from ultrathin Fe films (1992)

We present the results of a spin-polarized photoemission experiment that yields unambiguous evidence of layer-dependent core-level magnetic exchange splitting in ultrathin films. Analysis of the layer dependence of 3p-level spin polarization also establishes the existence of bulklike local magnetic order at 1.5 monolayer thickness.
Adolescent recognition of parental affect: Influence of depressive symptoms. (2011)

This study examined depressive biases in adolescents' labeling of parental affect. Adolescents (151 girls; 82 boys) and their parents engaged in videotaped problem-solving interactions. Adolescents then participated in a video-mediated recall procedure in which they watched the videotaped interaction and indicated how they thought their parents were feeling. Indices of parents' affect during the problem-solving interactions were also provided by parent self-report and behavioral observations. Adolescent depressive symptoms were associated with overreporting of parental aggressive affect and underreporting of parental happy and neutral affects, relative to both directly observed and self-reported parental affect. Depressive symptoms were not associated with overreporting of parental dysphoric affect. Given the importance of accurately reading affective cues for negotiating interpersonal interactions, these findings likely have implications for understanding processes that contribute to adverse relationships among the families of adolescents with depressive symptoms.
Taper Wear in Large Head Metal-on-Metal Hips (2011)

Introduction: Large Head Metal on Metal hips were introduced with the promise of lower wear rates, reduced chance of dislocation and an increased range of motion compared to conventional MoM hips. However, the 2010 National Joint Registry reports a 5 year failure rate of LHMoM hips of 7.8% compared to 6.3% for hip resurfacings and comparisons of well functioning hips have shown the LHMoM have significantly increased metal ion levels compared to resurfacings. These differences are despite LHMoM hips and resurfacings having identical bearings surfaces; thus the difference in in-vivo performance must be related to the modular head / neck taper junction. This study aims to examine the taper junctions of explanted LHMoM to try and understand the increased failure and metal ion levels.\n\nMethod: The internal taper inside the modular head and external taper on the femoral neck were examined using a Coordinate Measuring Machine (CMM), Roundness Machine and Optical Profilometer. The taper angle, cylindricity and wear were measured using the CMM and roundness machine, while the surface topography was measured using the Roundness machine (with diamond stylus) and optical profilometer. The surface topography was correlated with the wear measurements.\n\nResults and Discussion: There was a range of wear rates measured for the tapers ranging from the un-measureable to a 2 - 3 mm3, which is a similar magnitude to the volumetric wear from the bearing surface for typical hip joints. Examination of the surface topography revealed that in some cases the ridged surface texture of the neck had been worn into the surface of the inside taper of the head. Examination of the taper angles, revealed that the head was a more acute angle than the stem, suggesting that the contact will occur near the end of the neck, in the centre of the head. \n\nConclusion: Taper wear of LHMoM hips is a significant problem in some cases and may contribute to the elevated failure rate. The examination of explanted tapers provides a valuable insight into the in vivo behaviour of taper junctions and the wear mechanisms.
Calculation of Dispersion and Nonlinear Limited Maximum TDM and FDM Bit of Transform-Limited Pulses in Single-Mode Optical Fibers Effect Rates (1995)

Abstruct- The dispersion-limited maximum time-divisionmultiplexed (TDM) bit rates and the optical nonlinear-effectlimited maximum frequency-division multiplexed (FDM) channel numbers in single-mode optical fibers have been calculated for transform-limited optical pulses. The total bit rate attainable with combinations of TDM and FDM on Gaussian-type transform-limited pulses is about 7 TbUs in the typical 15 THz wide low-loss region of single-mode fibers at each of 1.3 and 1.5 pm wavelength bands. The maximum total bit rate attainable with dispersion-shifted (DS) fibers in the Er-doped fiber amplifier (EDFA’s) gain region of 1525-1565 nm is calculated to be about 2.3 TbUs, but reduces to 1.2 to 1.8 TbUs depending on fiber length for cases of a uniform TDM bit rate over the entire FDM channels. For DS fibers the four-wave mixing effect is a dominant effect limiting the channel power and the maximum FDM channel number, but for normal single-mode fibers the chromatic dispersion effect and cross-phase modulation (CPM) and stimulated Raman scattering (SRS) effects are dominant effects limiting the TDM bit rate and channel power, respectively.
Multi-user space-time coding in cooperative networks (2004)

Multiple antennas at the receiver and transmitter are often used to combat the effects of fading in wireless communication systems. However, implementing multiple antennas at mobile stations is impractical for most wireless applications due to the limited size of the mobile unit. We emulate spatial diversity using mobile relay stations, which cooperate by retransmitting the information received from a mobile station to a destination station. We propose an Alamouti based cooperative system with two relay stations and we provide an approximate formula for the average symbol error probability of this system in a Rayleigh fading environment.
A new three dimensional IC fabrication technology, stacking thin film DUAL-CMOS layers (1991)

A novel 3-D IC has been developed in which electrical function blocks of thin-film dual-active-device-layer (DUAL) CMOS ICs are bonded cumulatively. In the DUAL-CMOS ICs, pMOSFETs are stacked on nMOSFETs by using a laser beam annealing technique. By mechano-chemical polishing, the IC substrates are thinned, and then joined together. Operation of function blocks such as an inverter and ring oscillator stacked in the 3-D IC is confirmed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Layer‐by‐layer deposition of antimicrobial polymers on cellulosic fibers: a new strategy to develop bioactive textiles (2013)

In recent years, there has been an increase of infectious diseases caused by different microorganisms and the development of antibiotic resistance. In this way, the search for new and efficient antibacterial materials is imperative. The main polysaccharides currently used in the biomedical and pharmaceutical domains are chitin and its derivative chitosan (CH) and alginates (ALG). In this study, a simple technique of Layer by Layer (LbL) of applying polycation CH and polyanion ALG was used to prepare CH/ALG multilayers on cotton samples via the electrostatic assembly with success. The CH/ALG cotton samples (functionalized) were investigated for their antibacterial properties towards Staphylococcus aureus and Klebsiella pneumonia using the international standard method JIS L 1902:2002. The antibacterial activity of the functionalized samples was tested in terms of bacteriostatic and bactericidal activity, and results showed that the samples exhibited a bacteriostatic effect on the two bacteria tested, as expected. In addition, samples with five layers (CH/ALG/CH/ALG/CH) were more effective in inhibiting bacterial growth. This new coating for cellulosic fibers is a new strategy and may open new avenues for the development of antimicrobial polymers with potential application in health‐care field. Copyright © 2013 John Wiley & Sons, Ltd.
The Distribution of Grapevine Yellows Disease Associated with the Buckland Valley Grapevine Yellows Phytoplasma (2003)

Abstract Three blocks of Chardonnay in one vineyard in the Buckland Valley of Victoria, Australia, were surveyed over 4 years for grapevine yellows disease (GYd). Buckland Valley grapevine yellows phytoplasma (BVGYp) was the only phytoplasma detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis in GYd affected grapevines. GYd affected many grapevines and was characterized by remission of disease, some recurrence and occurrences in previously unaffected grapevines. A regional survey of the Buckland Valley indicated that both GYd and BVGYp occurred in the same restricted grape growing area. Within this area, BVGYp was detected in two vineyards that had been established using planting material from different sources. One could therefore speculate that BVGYp was present in these grapevines as a result of aerial transmission and was not present in the original planting material.
Tailoring of quantum well laser emission wavelength by antireflection facet coating (1991)

It is demonstrated that the lasing transition of a quantum well laser can be tailored to take place either between the n = 1 or n = 2 sub-band by proper design of the facet reflectivity. Facet reflectivity is controlled by monitoring the laser emission spectrum in situ during the deposition of antireflection (AR) coating.
A Theoretical Studies on the Gas Chromatography Accompanied with a Chemical Reaction (1965)

Theoretical equations based on the plate theory were applied to the discussion on the changes, observed on the gas chromatogram, when a chemical reaction of gas, A→B, occurs in the packing of the column. According to the equations, method was discussed to determine the theoretical plate number n, the rate constant of the chemical reaction K and the adsorption coefficient of A, kA, from the width of the peak, the retention volume and the area of the peak, and to determine the adsorption coefficient of B, kB, from the starting point of the peak of B. Then, the change of the position and the shape of chromatogram due to the variation of parameter values was discussed. By using these results, it was also shown for the isomerization reaction of cyclopropane that the theoretical and experimental chromatograms agree with each other.
Decellularization of Whole Human Liver Grafts Using Controlled Perfusion for Transplantable Organ Bioscaffolds (2017)

Liver transplantation is the only effective treatment for end-stage liver disease, but absolute donor shortage remains a limiting factor. Recent advances in tissue engineering focus on generation of native extracellular matrix (ECM) by decellularized complete livers in animal models. Although proof of concept has been reported for human livers, this study aims to perform whole liver decellularization in a clinically relevant series using controlled machine perfusion. In this study, we describe a mild nondestructive decellularization protocol, effective in 11 discarded human whole liver grafts to generate constructs that reliably maintain hepatic architecture and ECM components using machine perfusion, while completely removing cellular DNA and RNA. The decellularization process preserved the ultrastructural ECM components confirmed by histology, electron microscopy, and proteomic analysis. Anatomical characteristics of the native microvascular network and biliary drainage of the liver were confirmed by contrast computed tomography scanning. Decellularized vascular matrix remained suitable for normal suturing and no major histocompatibility complex molecules were detected, suggesting absence of allo-reactivity when used for transplantation. After extensive washing, decellularized scaffolds were nontoxic for cells after reseeding human mesenchymal stromal or umbilical vein endothelial endothelium cells. Indeed, evidence of effective recellularization of the vascular lining was obtained. In conclusion, we established an effective method to generate clinically applicable liver scaffolds from human discarded whole liver grafts and show proof of concept that reseeding of normal human cells in the scaffold is feasible. This supports new opportunities for bioengineering of transplantable grafts in the future.
Controlling chiral domain walls in antiferromagnets using spin-wave helicity (2018)

In antiferromagnets, the Dzyaloshinskii-Moriya interaction lifts the degeneracy of left- and right-circularly polarized spin waves. This relativistic coupling increases the efficiency of spin-wave-induced domain-wall motion and leads to higher drift velocities. We demonstrate that, in biaxial antiferromagnets, the spin-wave helicity controls both the direction and the magnitude of the magnonic force on chiral domain walls. In this case it is shown that the domain-wall velocity is an order of magnitude faster in the presence of the Dzyaloshinskii-Moriya interaction. In uniaxial antiferromagnets, by contrast, the magnonic force is always propulsive, but its strength is still helicity dependent.
Isolation and Properties of Prophosholipase A2 from Ox and Sheep Pancreas (1975)

Two prophospholipase A fractions, having a similar amino acid composition but different isoelectric points, have been isolated from ox pancreas. Upon tryptic activation both zymogens release an identical heptapeptide located at the N-terminal part of the chain giving rise to the formation of two isoenzymes. From sheep pancreas also two prophospholipases A were purified. The latter zymogens, however, differ only in the amino acid composition of the activation peptide and they produce the same active enzyme upon tryptic activation. The ruminant phospholipases show a strong resemblance in amino acid composition and kinetic behaviour, but they differ markedly from the porcine enzyme as regards pH optimum, specific activity and affinity for lipid/water interfaces.
Interstrand DNA Cross‐Linking 1, <i>N</i> 2‐Deoxyguanosine Adducts Derived from α,β‐Unsaturated Aldehydes: Structure–Function Relationships (2010)

This chapter contains sections titled: Introduction Interstrand Cross-Linking Chemistry of the γ-OH-PdG Adduct (9) Interstrand Cross-Linking by the α-CH3-γ-OH-PdG Adducts Derived from Crotonaldehyde Interstrand Cross-Linking by 4-HNE Carbinolamine Cross-Links Maintain Watson–Crick Base-Pairing Role of DNA Sequence Role of Stereochemistry in Modulating Cross-Linking Biological Significance Conclusions Acknowledgements References
Cold War Neurosis In U. S. Criticized (1958)

From the Rice Thresher Archive, a collection of newspaper articles published in the student newspaper for Rice University. Genre: News
Chromosomal protein HMGN1 modulates the expression of N‐cadherin (2005)

HMGN1 is a nuclear protein that binds to nucleosomes and alters the accessibility of regulatory factors to their chromatin targets. To elucidate its biological function and identify specific HMGN1 target genes, we generated Hmgn1-/- mice. DNA microarray analysis of Hmgn1+/+ and Hmgn1-/- embryonic fibroblasts identified N-cadherin as a potential HMGN1 gene target. RT-PCR and western blot analysis confirmed a linkage between HMGN1 expression and N-cadherin levels. In both transformed and primary mouse embryonic fibroblasts (MEFs), HMGN1 acted as negative regulator of N-cadherin expression. Likewise, the N-cadherin levels in early embryos of Hmgn1-/- mice were higher than those of their Hmgn1+/+ littermates. Loss of HMGN1 increased the adhesiveness, motility and aggregation potential of Hmgn1-/- MEFs, a phenotype consistent with increased levels of N-cadherin protein. Re-expression of wild-type HMGN1, but not of the mutant HMGN1 protein that does not bind to chromatin, in Hmgn1-/- MEFs, decreased the levels of N-cadherin and restored the Hmgn1+/+ phenotype. These studies demonstrate a role for HMGN1 in the regulation of specific gene expression. We suggest that in MEFs, and during early mouse development, the interaction of HMGN1 with chromatin down-regulates the expression of N-cadherin.
Oculomotor executive function abnormalities with increased tic severity in Tourette syndrome (2014)

In a highly controlled design, the findings demonstrate for the first time that increased tic severity in TS is associated with impaired response inhibition and impaired working memory and that these executive function deficits cannot be accounted for by differences in age, medication or comorbid symptom severity.
Deep domain models for discourse analysis (2003)

The authors address the problem of discourse analysis, and in particular finding causal relations between facts mentioned in messages, using a detailed domain model. This work is part of the PROTEUS (Prototype Text Understanding System) project, whose objective is to understand short narrative message about equipment installed in Navy ships. Casualty reports (CASREPs) describe failures of this equipment, together with maintenance actions performed by the crew onboard. To capture the domain knowledge, the authors built a model of the equipment installed on the ship (initially, the starting air system) and demonstrated is use in several aspects of language understanding. The PROTEUS system has been substantially implemented and debugged and has been publically demonstrated operating on a small set of actual CASREPs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Binding and uptake of exogenous isoferritins by cultured human erythroid precursor cells (1994)

The interaction of extracellular human isoferritins with normal erythroid precursors developing in a two-phase liquid culture was studied. Cells at the stage of polychromatic normoblasts exhibited substantial specific binding of radioiodinated placental isoferritins. Considerably more acidic isoferritin was bound than basic isoferritin. The binding of ferritin was significantly higher at 37 degrees C than at 4 degrees C. All of the 125I-acidic isoferritin bound at 4 degrees C, but only part of that bound at 37 degrees C, could be dislodged by the addition of 500-fold excess of non-labelled acidic isoferritin. Acidic isoferritin displaced radio-iodinated acidic isoferritin from the erythroid cells more efficiently than intermediate or basic isoferritins. Kinetic analysis suggests a dissociation constant (Kd) of 3.9 x 10(-8) M for acidic ferritin and 3.7 x 10(-7) M for basic isoferritin. The average number of binding sites for acidic isoferritin was 1.3 x 10(5) per cell. The results point to specific binding and receptor-mediated internalization for predominantly acidic isoferritin by developing human erythroid cells.
Regulation of Phenylalanine and Tyrosine Biosynthesis in Pseudomonas aureofaciens ATCC 15926 (1980)

Association patterns and regulatory properties of chorismate mutase, prephenate dehydratase and prephenate dehydrogenase from Pseudomonas aureofaciens ATCC 15926 were studied. Prephenate dehydrogenase (molecular weight 95000) was separated by Sephadex G-100 chromatography from both the chorismate mutase-prephenate dehydratase I complex (molecular weight 75000) and from a second, low molecular weight prephenate dehydratase (prephenate dehydratase II; molecular weight 30000). The chorismate mutase-prephenate dehydratase complex persisted after DEAE-Sephadex A-50 chromatography. With the exception of prephenate dehydratase II, enzyme activities were influenced by endproducts. Chorismate mutase was competitively inhibited by L-phenylalanine (Ki=3.5 microM). Prephenate dehydratase I was inhibited by L-phenylalanine (Ki=8 microM) and activated by L-tyrosine (Ka=5 microM). Prephenate dehydrogenase was feedback-inhibited by L-tyrosine. Substrate saturation curves of chorismate mutase and of prephenate dehydratase II were hyperbolic with Km values of 0.31 mM for chorismate and 0.015 mM for prephenate, respectively. The substrate saturation curve of the complexed prephenate dehydratase I was sigmoid; a Km value of 0.18 mM was calculated for prephenate. Chorismate mutase, prephenate dehydratase and prephenate dehydrogenase were not repressed by aromatic amino acids.
ChemInform Abstract: Synthesis of Polyfunctionalized 2,5‐Dicarboxylated Pyrrolidine Derivatives by 1,3‐Dipolar Cycloaddition Reactions of Azomethine Ylides. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fuzzy Mathematical Morphology Based on Fuzzy Inclusion (2000)

Fuzzy mathematical morphology has been developed to soften the classical binary morphology so as to make the operators less sensitive to image imprecision. It can also be viewed simply as an alternative gray-scale morphological theory. This chapter discusses the manner in which fuzzy morphologies result from the fuzzification of subsethood by using inclusion indicators. There are a number of axioms that an inclusion indicator should satisfy to give an operational structure that extends the basic propositions of the classical morphological algebra. Indicators that do not satisfy all of these axioms may still be useful, albeit, at the cost of invalidating basic properties typically associated with morphological operators. This chapter describes the structure of inclusion-indicator fuzzy morphology, describes various indicators that have appeared in the literature, explains the manner in which binary morphological algorithms lift to fuzzy algorithms, provides some basic representation theorems for fuzzy morphological operators, and shows how one can define approximate convexity in this context.