gebhart/patrepeval huggingface dataset:
Movement of <i>Pseudomonas aureofaciens</i> from the rhizosphere to aerial plant tissue (1996)

Following inoculation onto seeds, the rhizobacterium Pseudomonas aureofaciens Ps3732RNL11 (L11), which contains the constituitively expressed lacZ and lacY genes from Escherichia coli, was recovered from the interior of aerial tissues of all 16 monocot and dicot plants tested, and the exterior of aerial surfaces of 15. In more detailed studies with corn, wheat, and broccoli, both Ps3732RNL11 and its nonengineered parent strain PS3732RN (RN) rapidly established large populations on all root systems and smaller densities within the aerial tissues, all of which persisted at stable levels throughout 12- to 23-day test periods. There were no differences in the behavior of L11 and RN on any of the three plant species. L11 invaded the aeriel tissues of corn in at least two distinct ways. First, it moved into the interior of leaves following inoculation of guttation drops, suggesting that the bacteria may contaminate the developing shoot prior to its emergence from the soil and then invade through natural openings. However, when this route was blocked by inoculating the roots after shoot emergence in either soil or hydroponic systems, the bacteria still invaded the aerial tissues within 24 h, suggesting direct vascular transport from the roots. Such bacterial movement is an important consideration in future field releases of both native and genetically modified rhizobacteria.Key words: rhizosphere, genetically engineered microorganism, Pseudomonas aureofaciens.
Photonic Generation of Phase-Coded Microwave Signal With Large Frequency Tunability (2011)

A photonic approach to realizing phase-coded microwave signal generation with large frequency tunability is proposed and demonstrated. Two coherent optical wavelengths are generated based on external modulation by biasing a Mach-Zehnder modulator (MZM) at the minimum transmission point to generate ±1 -order sidebands while suppressing the optical carrier. The two ±1-order sidebands are then sent to a fiber Sagnac interferometer (SI) incorporating an optical phase modulator (PM) and a broadband flat-top fiber Bragg grating (FBG), with one of the sidebands being phase modulated at the PM. A frequency tunable phase-coded microwave signal is generated by beating the two sidebands at a photodetector (PD). The proposed technique is experimentally investigated. The generation of a frequency tunable phase-coded microwave signal at 22 and 27 GHz is demonstrated.
Silicon-transition metal chemistry. I. Photochemical preparation of silyl(transition metal) hydrides (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSilicon-transition metal chemistry. I. Photochemical preparation of silyl(transition metal) hydridesWilliam A. G. Graham and W. JetzCite this: Inorg. Chem. 1971, 10, 1, 4–9Publication Date (Print):January 1, 1971Publication History Published online1 May 2002Published inissue 1 January 1971https://pubs.acs.org/doi/10.1021/ic50095a002https://doi.org/10.1021/ic50095a002research-articleACS PublicationsRequest reuse permissionsArticle Views584Altmetric-Citations118LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Roles and regulation of membrane-associated serine proteases (2007)

Pericellular proteolytic activity affects many aspects of cellular behaviour, via mechanisms involving processing of the extracellular matrix, growth factors and receptors. The serine proteases have exquisitely sensitive regulatory mechanisms in this setting, involving both receptor-bound and transmembrane proteases. Receptor-bound proteases are exemplified by the uPA (urokinase plasminogen activator)/uPAR (uPAR receptor) plasminogen activation system. The mechanisms initiating the activity of this proteolytic system on the cell surface, a critical regulatory point, are poorly understood. We have found that the expression of the TTSP (type II transmembrane serine protease) matriptase is highly regulated in leucocytes, and correlates with the presence of active uPA on their surface. Using siRNA (small interfering RNA), we have demonstrated that matriptase specifically activates uPAR-associated pro-uPA. The uPA/uPAR system has been implicated in the activation of the plasminogen-related growth factor HGF (hepatocyte growth factor). However, we find no evidence for this, but instead that HGF can be activated by both matriptase and the related TTSP hepsin in purified systems. Hepsin is of particular interest, as the proteolytic cleavage sequence of HGF is an 'ideal substrate' for hepsin and membrane-associated hepsin activates HGF with high efficiency. Both of these TTSPs can be activated autocatalytically at the cell surface, an unusual mechanism among the serine proteases. Therefore these TTSPs have the capacity to be true upstream initiators of proteolytic activity with subsequent downstream effects on cell behaviour.
Bio-Heat Models Revisited: Concepts, Derivations, Nondimensalization and Fractionalization Approaches (2019)

The heat transfer in living tissues is an evergreen problem in mathematical modeling with great practical importance starting from the Pennes equation postulation. This study focuses on concept in model building, the correct scaling of the bio-heat equation (one-dimensional) by appropriate choice of time and length scales, and consequently order of magnitude analysis of effects, as well as fractionalization approaches. Fractionalization by different constitutive approaches, leading to application of different fractional differential operators, modeling the finite speed of the heat wave, is one of the principle problems discussed in the study. The correct choice of the damping (relaxation) function of the heat flux is of primarily importance in the formulation of the bio-heat equation with memory. Moreover, this affects the consequent scaling, order of magnitude analysis and solutions.
Educating Young New Immigrants: How Can the United States Cope? (1990)

ABSTRACT Evolving local, regional and world events have generated a large number of exigencies. In recent times some of these exigencies have sent segments of populations fleeing from such manifestations as war, repression, hunger, natural disasters, famine, violence, or the purely fundamental humane desire for religious, political, and economic freedom. Dramatic population shifts have become a sequel of many national and international conflicts. As the ‘push’ effects serve to exacerbate the outflow of small and large groups of population segments, the ‘pull’ effects, serving as countervailing forces, attract those persons who join the ranks of immigrants. This article looks at some cogent issues surrounding the broader dynamics of immigrants and immigration, then specifically addresses the situation in the United States of America, where, as in the case of some other western-oriented, highly developed nations, school-age children of immigrants, who come largely from Third World countries, have been entering schools in unprecedented numbers, and, are thus creating concomitant demands from schools and school people alike, for their accommodation, adjustment, and socialization.
A software tool for academic advisors for student performance follow-up (2002)

The features of an interactive computer graphics facility to be used by academic advisors for student performance evaluation and follow-up is developed. Incorporating good visual effects, the software has been designed to provide a flexible, user friendly interface. The tool provides a screen on which the courses that each student has to take in order to satisfy his/her degree requirement and corresponding grades on term bases are displayed. The tool has also a "scenario" program which creates a virtual environment on which hypothetical grades to the various courses that the student has to take and/or repeat can be assigned and the corresponding cumulative grade point average obtained easily and quickly. Furthermore, the facility can be used for adding and/or dropping courses for registration purposes and hard-copy of screens can be obtained on use demand. The facility leads to efficient use of the student advisors time with many attendant advantages.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Disorders of Childhood and Adolescence: Gender and Psychopathology (2008)

Early-onset disorders (e.g., conduct problems, autism) show a marked male preponderance, whereas adolescent-onset disorders (e.g., depression, anxiety) show a marked female preponderance. A developmental psychopathology framework provides a means to investigate complex gender-related etiologies of these different disorders. This review focuses on biological and environmental factors implicated in the development of conduct problems and depression in boys and girls. Boys and girls showed certain differences in types, rates, comorbidities, antecedents, correlates, and trajectories of these problems. Origins of male and female preponderant problems are likely to be rooted, in part, in biological, physical, cognitive, and social-emotional differences in boys and girls that can precede the expression of clinical problems. These male-like and female-like characteristics are considered regarding conduct problems and depression to explore how they inform biological and environmental theories about gender and psychopathology. At the same time, because boys and girls also show many similarities, it is important to avoid sex-stereotyping mental health problems.
Proteomics. (2006)

Proteomics was started in a collaborative research of two groups of Humphery-Smith and Keith Williams in 1995. The proteomics played an initiative role in succeeding development of various “-omics” researches. And it should be pointed out that the two-dimensional polyacrylamide gel electrophoresis originally reported by O'Farrell in 1975 might be the origin of the proteomics. The two-dimensional gel electrophoresis demonstrated its excellent resolution in separation of proteins in crude extracts. However the 2-D gel method had yet several difficulties. The first problem was the lack in imaging analyzer for 2-D gels, and the second was the poorness in reproducibility. Those problems were later resolved by development in computer-aided image analyzers and improvement in the first-dimensional isoelectric focusing on an immobilized pH gradient.
<i>Nardostachys jatamansi</i> Improves Learning and Memory in Mice (2006)

Cure of cognitive disorders such as amnesia, attention deficit, and Alzheimer's disease is still far from being realized in the field of medicine. Nootropic agents such as piracetam, aniracetam, and choline esterase inhibitors like donepezil are being used for improving memory, mood, and behavior, but the resulting side effects associated with these agents have made their applicability limited. In Ayurveda, the roots of Nardostachys jatamansi have been clinically employed for their anti-ischemic, antioxidant, anticonvulsant, and neuroprotective activities. The present study was undertaken to assess the potential of N. jatmansi as a memory enhancer. The elevated plus maze and the passive avoidance paradigm were employed to evaluate learning and memory parameters. Three doses (50, 100, and 200 mg/kg, p.o.) of an ethanolic extract of N. jatamansi were administered for 8 successive days to both young and aged mice. The 200 mg/kg dose of N. jatmansi ethanolic extract significantly improved learning and memory in young mice and also reversed the amnesia induced by diazepam (1 mg/kg, i.p.) and scopolamine (0.4 mg/kg, i.p.). Furthermore, it also reversed aging-induced amnesia due to natural aging of mice. As scopolamine-induced amnesia was reversed, it is possible that the memory improvement may be because of facilitation of cholinergic transmission in the brain. Hence, N. jatmansi might prove to be a useful memory restorative agent in the treatment of dementia seen in elderly persons. The underlying mechanism of action can be attributed to its antioxidant property.
Osteoprotegerin Deficiency Limits Angiotensin II–Induced Aortic Dilatation and Rupture in the Apolipoprotein E–Knockout Mouse (2014)

These findings support a role for osteoprotegerin in aortic aneurysm through upregulation of CTSS, matrix metalloproteinase 2, and matrix metalloproteinase 9 within the aorta, promoting an inflammatory phenotype in aortic vascular smooth muscle cells in response to angiotensin II.
High Schoolers Have a Key to College (1951)

When you 4-Hers go to college, you'll find that many social, cultural and educational "rough edges" have already been knocked off if you've taken part in the wide and worthwhile experiences offered you by the 4-H Club.
Modeling Springback in Stamped Automotive Structures (2010)

In sheet metal forming, the discrepancy between the fully loaded shape at the end of forming stage and the unloaded configuration is called springback. Springback is a major factor in preventing accurate dimensions of final products. Therefore, it is very important that springback be quantitatively predicted and compensated in the die design stage. In sheet metal stamping, especially when drawbead is used, the material experiences several cycles of bending-unbending-reverse bending. Therefore, in to order to accurately predict springback, the constitutive model must be able to accurately describe the material behaviour during cyclic loading. Yoshida-Uemori (YU) two-surface model is one of the most sophisticated models which is capable of reproducing the transient Bauschinger effect, permanent softening and workhardening stagnation. In this work, two different yield functions, i.e. Hill’s 1948 and Yld 2000-2d, were used in conjunction with YU two-surface model. Moreover, two different numerical procedures were developed for numerical implementation of these models: a) a semi-implicit approach and b) a fully-implicit approach. The numerical procedures were used to develop user material subroutines for ABAQUS commercial software. Then, the subroutines were used to evaluate the capability of the model in prediction of springback for a channel draw process. In addition, the isotopic hardening (IH) and combined isotropic-nonlinear kinematic hardening (IH+NKH) models were also used to predict the springback of the problem. Finally, the springback profiles obtained by each model were compared with the experimental data. For DP600, the error in springback prediction is around 3% when YU model is used. For HSLA and AA6022, the error associated with YU model is less than 3% and 13% at 25% and 100% drawbead penetrations, respectively. The YU model does not predict the springback accurately for AKDQ and the error is around 30%. The results also show that the IH model overestimates the springback for all materials. For DP600 and AA6022, the results obtained by IH+NKH model are the same as those obtained by YU model. However, the YU model considerably improves the springback prediction compared to IH+NKH model for HSLA; while for AKDQ the IH+NKH model improves the springback prediction compared to YU model.
Hardware Implementation of Authentication Algorithm Based on CCMP on Wireless Network (2008)

RN(SResidue Number System)is a kind of integer operation system,and it allows interesting advantages in terms of precision, power, consumption and speed. CCMP is an agreement about encryption and authentication on WLAN. This paperpresents a general algorithm based on RNS. The algorithm can process high-level cipher analysis,and show the fastest in the following comparions.
The scorpion envenomation in the region of Faouar-KEBILI at 2010-2012 : study of 421 cases. (2016)

Prevention and education, especially in endemic period still remain indispensable in the fight against scorpion envenomation.
Influence of photoperiod duration and light–dark transitions on entrainment of <i>Per1</i> and <i>Per2</i> gene and protein expression in subdivisions of the mouse suprachiasmatic nucleus (2009)

The circadian clock located within the suprachiasmatic nuclei (SCN) of the hypothalamus responds to changes in the duration of day length, i.e. photoperiod. Recently, changes in phase relationships among the SCN cell subpopulations, especially between the rostral and caudal region, were implicated in the SCN photoperiodic modulation. To date, the effect of abrupt, rectangular, light-to-dark transitions have been studied while in nature organisms experience gradual dawn and twilight transitions. The aim of this study was to compare the effect of a long (18 h of light) and a short (6 h of light) photoperiod with twilight relative to that with rectangular light-to-dark transition on the daily profiles of Per1 and Per2 mRNA (in situ hybridization) and PER1 and PER2 protein (immunohistochemistry) levels within the rostral, middle and caudal regions of the mouse SCN. Under the short but not under the long photoperiod, Per1, Per2 and PER1, PER2 profiles were significantly phase-advanced under the twilight relative to rectangular light-to-dark transition in all SCN regions examined. Under the photoperiods with rectangular light-to-dark transition, Per1 and Per2 mRNA profiles in the caudal SCN were phase-advanced as compared with those in the rostral SCN. The phase differences between the SCN regions were reduced under the long, or completely abolished under the short, photoperiods with twilight. The data indicate that the twilight photoperiod provides stronger synchronization among the individual SCN cell subpopulations than the rectangular one, and the effect is more pronounced under the short than under the long photoperiod.
Pharmacogenetics of Drug Metabolising Enzymes: Importance for Personalised Medicine (2003)

The number of polymorphisms identified in genes encoding drug metabolising enzymes, drug transporters, and receptors is rapidly increasing. In many cases, these genetic factors have a major impact on the pharmacokinetics and pharmacodynamics of a particular drug and thereby influence the sensitivity to such drug in an individual patient with a certain genotype. The highest impact is seen for drugs with a narrow therapeutic index, with important examples emerging from treatment with antidepressants, oral anticoagulants, and cytostatics, which are metabolised by the polymorphic enzymes cytochrome P450 2D6 (CYP2D6), cytochrome P450 2C9 (CYP2C9), and thiopurine-S-methyltransferase (TPMT), respectively. In order to apply the increasing amount of pharmacogenetic knowledge to clinical practise, specific dosage recommendations based on genotypes will have to be developed to guide the clinician, and these recommendations will have to be evaluated in prospective clinical studies. Such development will lead to a patient-tailored drug therapy which hopefully would be more efficient and will result in fewer adverse drug reactions.
Hacking Health Care: Authentication Security in the Age of Meaningful Use (2014)

The rapid adoption of EHRs (Electronic Health Records), to store and communicate highly personal data, raises serious concerns in terms of privacy, security, and civil and criminal liability. This note will examine the current statutory framework for addressing electronic breaches in the health care context, examine the vulnerabilities of EHRs, and look to the established world of online banking for possible legislative and practical solutions to the challenge of keeping private health information private. Finally, this note will propose key amendments to the Health Insurance Portability and Accountability Act (HIPAA) regulations to enhance authentication security.
A Flow Synthesis of Gallium Phosphide and Some Properties of Gallium Phosphide Powder Layers (1962)

A simplified synthesis of gallium phosphide powder in an open flow‐system is described. Phosphorus vapor is carried over gallium (III) oxide by a stream of hydrogen. The oxide undergoes complete conversion to phosphide at about 1000°C. A thermal treatment enhances average particle size, and electroded powder layers are fabricated. Electrical properties and electroluminescence characteristics of these layers are reported.
Anonymity in a Mobile Computing Environment (1994)

In a mobile computing environment, it is desirable to protect information about the movements and activities of mobile entities from onlookers. Solutions to this problem of providing anonymity have to be developed with the constraints of mobile computing environments in mind. In this paper, it is argued that this issue merits investigation. A brief survey of the nature of anonymity provided in proposed or existing mobile computing environments is presented. It is argued further that achieving limited but practical anonymity using standard cryptographic techniques is feasible. Example solutions are presented.
1,<i>N</i><sup>6</sup>-etheno-2′ -deoxyadenosine and 3,<i>N</i><sup>4</sup>-etheno-2′-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride (1989)

1,N6-Etheno-2'-deoxyadenosine (epsilon dAdo) and 3,N4-etheno-2'-deoxycytidine (epsilon dCyd) are formed in vitro by reaction of DNA with the electrophilic metabolites of vinyl chloride (VC), chloroethylene oxide and chloroacetaldehyde. To detect and quantitate these DNA adducts in vivo, we have raised a series of specific monoclonal antibodies (Mab). Among those, Mab EM-A-1 and Mab EM-C-1, respectively, were used for detection of epsilon dAdo and epsilon dCyd by competitive radioimmunoassay (RIA), following pre-separation of the etheno adducts from DNA hydrolysates by high performance liquid chromatography. At 50% inhibition of tracer-antibody binding, both Mab had a detection limit of 187 fmol and antibody affinity constants (K) of 2 x 10(9) l/mol. The levels of epsilon dAdo and epsilon dCyd were quantitated in the DNA of lung and liver tissue of young Sprague-Dawley rats exposed to 2000 p.p.m. of VC for 10 days. The epsilon dAdo/2'-deoxyadenosine and epsilon dCyd/2'-deoxycytidine molar ratios were 1.3 x 10(-7) and 3.3 x 10(-7), respectively, in lung DNA, and 5.0 x 10(-8) and 1.6 x 10(-7) in liver DNA. When hydrolysates of 3 mg of DNA were analyzed by RIA at 25% inhibition of tracer-antibody binding, epsilon dAdo and epsilon dCyd were not detected in liver DNA from untreated rats above the limiting epsilon dAdo/2'-deoxyadenosine and epsilon dCyd/2'-deoxycytidine molar ratios of 2.2 x 10(-8) and 3.1 x 10(-8), respectively.
Apical and Basal Regulation of the Permeability of the Retinal Pigment Epithelium (2003)

Diffusible factors secreted by the neural retina acted synergistically with basolateral stimulation to regulate the structure and function of RPE tight junctions. Serum on the apical side of the RPE monolayer inhibited the ability of retinal factors to upregulate the tight junction barrier.