gebhart/patrepeval huggingface dataset:
HTS/ferroelectric thin films for tunable microwave components (1995)

We report on the electrical characterization of Ba/sub 0.5/Sr/sub 0.5/TiO/sub 3//YBa/sub 2/Cu/sub 3/O/sub 7-/spl delta///LaAlO/sub 3/ multilayer structure. This structure was fabricated using a pulsed laser deposition technique yielding film thicknesses of 300 nm and 800 nm for the YBa/sub 2/Cu/sub 3/O/sub 7-/spl delta// (YBCO) and the Ba/sub 0.5/Sr/sub 0.5/TiO/sub 3/ (BST) films, respectively, A transition temperature T/sub c/=91.5 K was measured for the YBCO film in this structure after deposition of the BST layer. The structure was patterned into parallel plate capacitors with 400/spl times/400 /spl mu/m gold contacts and YBCO electrodes on top and underneath the BST, respectively. A relative dielectric constant (/spl epsiv//sub r/)/spl sim/425 and a loss tangent (tan/spl delta/)=0.010 were measured at 1.0 MHz at 298 K and zero dc voltage (V/sub dc/=0 volts). At 77 K, the dielectric data showed 320/spl les//spl epsiv//sub r//spl les/360 and tan/spl delta/=0.036 at V/sub dc/=0 volts. For 5.0/spl ges/V/sub dc//spl ges/-3.0 volts /spl epsiv//sub r/ could be varied from 180 to 370. For -5.0/spl les/V/sub dc//spl les/-3.0 volts, /spl epsiv//sub r/ decreased rapidly with little change in tan/spl delta/. The /spl epsiv//sub r/ versus V/sub dc/ data suggest that changes in /spl epsiv//sub r/ were affected by electrode space charge layers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reduction of maleate dianion at a mercury electrode in aqueous solution. A CEEC or CECE mechanism? (1990)

The reduction of maleate dianion at a mercury electrode in aqueous solution is investigated using rotating disc electrode (RDE) voltammetry. Candidate reduction mechanisms are shown to be CEEC, CECE, and CECEh and equations are derived, relating the dependence of the transport-limited current to the RDE rotation speed and the rate constants for the C steps, for each of these processes. The interpretation of experimental data in terms of the theories points to reduction occurring via a CEEC rather than a CECE, mechanism as previously believed.
A system with predictive least-squares mathematical models for monitoring wildlife conservation sites using GIS and remotely-sensed data (1996)

Abstract Today there is a worldwide trend towards protecting the environment and its natural resources. This goal is achieved using different procedures and techniques. Remote sensing and geographical information systems, however, are two of the most suitable techniques for monitoring, analysing, and managing Earth resources. Conserved natural areas for wildlife is one of the most important natural resources that should be explored using GIS and RS technologies In this study, a prototype GIS that can integrate remotely-sensed data to monitor conservation areas (for wildlife) in arid and semi-arid regions is developed. The system uses TM images and other heuristic information to perform its analysis and prediction. Future change in land-cover is anticipated by mathematical models. The mathematical models are developed by this study based on the concepts of least-squares theories and techniques. The system is operational. It is tested using an area in Saudi Arabia. The obtained results showed that the system is accurate.
On Rotational Relaxation as a Cause of the Anomalous Ultrasonic Absorption of Ethyl Acetate (1953)

The analysis by Kneser of the ultrasonic absorption data for ethyl acetate (H3COC-OCH2CH3) reveals the existence of two relaxational processes, the larger of which has a characteristic frequency of 70 Mc/sec. The hypothesis will be advanced that the mechanism of this process is the relaxation of the hindered rotation (more precisely, libration) of the ethoxyl (−OCH2CH3) group. Applying the usual two-state theory to Kneser's value for the maximum of the excess absorption per wavelength shows that the relaxational heat capacity must be 0.17 cal/mole/C°. The fact that the dipole moment is temperature-independent shows that the barrier which restricts the rotation must be greater than 10 RT. Hence the approximation of a harmonic oscillator may be used to calculate the barrier height that would give rise to this heat capacity. The result is about 15 kcal. To check this a formula of Chandrasekhar was used to compute the barrier height required by a relaxation frequency of 70 Mc/sec. The result here is about 13.5 kcal, in reasonable agreement considering the approximations involved. The results of more refined calculations will be presented, and other possible applications will be considered.
Safety of Tissue Plasminogen Activator for Acute Stroke in Menstruating Women (2002)

Intravenous tPA may be administered relatively safely in women who are menstruating and should be used with caution in women with a history of dysfunctional uterine bleeding. Potential patients should be advised that they might require transfusion for increased menstrual flow.
On the Development of Viable Cruciform-Shaped Specimens: Towards Accurate Elevated Temperature Biaxial Testing of Lightweight Materials (2010)

This paper is focused on the development of viable cruciform-shaped specimen geometries where large biaxial plastic deformation can be achieved within their gauge areas. A custom-built balanced biaxial testing fixture is used to plastically deform a variety of carefully-designed AZ31B-H24 magnesium specimens until failure. Images recorded from a digital camera positioned to monitor deformation in the gauge area of each specimen are used to compute the strain fields with a digital image correlation (DIC) algorithm. The viability of each design is validated based on the extent of biaxiality of measured strains and its ability to promote plastic deformation within its gauge area up until failure. The study provides key insights into the influences of certain geometrical parameters on deformation-biaxiality in cruciform specimens.
Mixed digital/analog signal processing for a single-chip 251Q U interface transceiver (1990)

Careful partitioning of signal-processing tasks between the analog and digital domains to exploit the strengths of each results in an efficient design of a 2B1Q ISDN basic-rate U-interface single-chip transceiver. This 5-V CMOS device provides transmission across the digital subscriber line at 160 kb/s full duplex, in full compliance with ANSI standard T1.601. The serial 2B+D data from the digital interface is rate-adapted to 160 kb/s and cyclic redundancy check (CRC), maintenance, and control bits are inserted in the digital interface (DIF) section of the circuit. The resulting data stream is then scrambled and 18-b synchronization words are inserted. Conversion to an 80-kHz four-level signal takes place in the line encoder. The transmitter includes a 2B1Q pulse shaper, a five-level fully differential pulse-duration-modulation digital-to-analog (PDM D/A) converter, a third-order transmit filter, and a fully differential line driver. A raised-cosine 78% time-roll-off pulse is stored in the pulse shaper, using a PDM code, at 96 samples per baud. Pulse symmetry allows storage of the first half-pulse only. The back half is generated by a time-mirror circuit. At every baud interval, the current di-bit encodes the pulse front half, while the past di-bit encodes the pulse back half. The two resulting quantities are then combined and provided to a 7.68-MHz five-level PDM D/A converter. Undesirable high-frequency components are eliminated by one pole of low-pass filtering in the D/A converter circuit and two extra poles in the line drive circuit.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Glucose-induced polypyrimidine-tract-binding protein (PTB) to the 3´-untranslated region of the insulin mRNA is inhibited by rapamycin (2002)

Although extensively studied, there are still many unanswered questions regarding the exact regulation of insulin gene expression. This is important to further investigate since it will hopefully help us understand the pathophysiology of some types of diabetes. The insulin mRNA has a long half-life and it is therefore likely to be regulated through specific mechanisms. The aim of the present work was to evaluate the importance of the 3´untranslated region (UTR) of the insulin mRNA in the regulation of insulin mRNA stability. The number of insulin mRNA molecules/rat β-cell was first determined to be 20 000 - 100 000, depending on the glucose concentration of the culture medium. However, the insulin mRNA level was neither increased by glucose nor insulin when stimulated for only one hour. Glucose withdrawal for 16 h caused only a small decrease in insulin mRNA levels. This decrease was of the same magnitude in the presence of a transcriptional inhibitor, indicating that the insulin mRNA stability significantly contributes to the regulation of insulin gene expression. To study the mechanisms by which glucose regulates insulin mRNA stability, we probed for protein binding to the rat and human 3´UTR insulin mRNA (ins-PRS) using the electrophoresis mobility shift assay. Specific binding was observed and the protein was identified as the polypyrimidine tract-binding protein (PTB). Introduction of the ins-PRS in to the 3´UTR of a reporter gene mRNA did not significantly affect the mRNA stability. However, mutation of the ins-PRS and disruption of PTB binding resulted in a marked decrease in expression of the reporter gene mRNA. The binding activity was increased in islets in response to glucose, hypoxia, sphingomyelinase (an inducer of endogenous ceramide) and in vitro by the addition of the reducing agent dithiothreitol (DTT). The hypoxia-induced binding activity was counteracted by exogenous administration of hydrogen peroxide, while the glucose-induced PTB binding activity was inhibited by rapamycin, which is an inhibitor of mTOR and p70s6 kinase. The insulin mRNA levels were increased in response to hypoxia, equal to the increase in response to glucose. In conclusion, PTB binding to the ins-PRS is an important, but not sufficient, event in regulation of insulin mRNA stability. Binding activity is increased in response to glucose and hypoxia, possibly mediated through pathways involving the redox status and/or reactive oxygen species (ROS), ceramide and mTOR/p70s6k.
Contribution of Paretic and Nonparetic Limb Peak Propulsive Forces to Changes in Walking Speed in Individuals Poststroke (2016)

Gait retraining in the chronic phase of stroke recovery facilitates paretic limb neuromotor recovery and reduces the reliance on the nonparetic limb's generation of propulsive force to increase walking speed. These findings support gait rehabilitation efforts directed toward improving the paretic limb's ability to generate propulsive force.
Amiloride Derivatives as Blockers of Na<sup>+</sup>/Ca<sup>2+</sup>Exchange: Effects on Mechanical and Electrical Function of Guinea‐Pig Myocardium (1992)

The amiloride derivatives, 2',3'-benzobenzamil (BB), 3',4'-dichlorobenzamil (DCB), and 5-(N-4-chlorobenzyl)-2',4'-dimethylbenzamil (CBDB) are known as inhibitors of the Na+/Ca2+ exchange. This kind of drug action was recently suggested to be a new inotropic mechanism. In guinea-pig myocardium, we have studied the inotropic and the accompanying electrophysiological effects of the three compounds in order to assess their selectivity of action. In left atria and in papillary muscle, force of contraction increased with DCB and CBDB (atria only) at a high concentration (5 x 10(-5)-10(-4) mol/l) and after long exposure time, whereas BB produced a negative inotropic effect. In the isolated perfused Langendorff heart, the amiloride derivatives tested decreased spontaneous heart rate and force of contraction and prolonged the duration of contraction. In isolated cardiac myocytes, sodium current, calcium current and the delayed rectifier were reduced by concentrations of BB, DCB and CBDB similar to the IC50 values reported for the inhibition of the Na+/Ca2+ exchange. Our results demonstrate that the amiloride derivatives have multiple sites of action. It is concluded that more specific modulators of the Na+/Ca2+ exchange are required in order to define their contribution to the regulation of contractile activation of the heart.
Essential thrombocythemia: scientific advances and current practice (2006)

Although it is in vogue to consider essential thrombocythemia as more than one disease in terms of both molecular phenotype (presence or absence of JAK2(V617F)) and putative pattern of myelopoiesis (monoclonal versus polyclonal), it is yet to be shown that such differences influence either the natural history of the disease or current therapy. From a treatment standpoint, hydroxyurea is now confirmed to be the drug of choice for high-risk patients with essential thrombocythemia.
De-escalation training in an augmented virtuality space (2016)

This poster describes the TeachLivE paradigm, its application to de-escalation training, especially for law enforcement personnel, and the realization of this in a four-walled augmented virtuality space. Emphasis is placed on how the resulting physical presence increases co-presence and social presence, leading to an immersive and effective learning environment.
Methods for the Preparation of Standardized Immunofluorescent Reagents of Increased Specificities (1968)

Journal Article Methods for the Preparation of Standardized Immunofluorescent Reagents of Increased Specificities Get access Milan Wickerhauser, Ph.D., Milan Wickerhauser, Ph.D. Research Division, Hyland Laboratories, Los Angeles, California 90039 Search for other works by this author on: Oxford Academic Google Scholar Bill D. Pethtel, B.A. Bill D. Pethtel, B.A. Research Division, Hyland Laboratories, Los Angeles, California 90039 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 50, Issue 5, 1 November 1968, Pages 575–581, https://doi.org/10.1093/ajcp/50.5.575 Published: 01 November 1968 Article history Received: 21 December 1967 Published: 01 November 1968
Editorial (2021)

Welcome to the fourth issue of the JOURNAL ON SELECTED AREAS IN INFORMATION THEORY (JSAIT), dedicated to “Privacy and Security of Information Systems.”
Comparative analysis of serum proteins by chemical and electrophoretic means: An experiment in biochemistry (1954)

This experiment consisted of an orientation lecture on electrophoresis, demonstration of the instrument (Tiselius), interpretation of patterns, and presentation of photoprint copies on rectangular coordinate graph paper of the pattern for an experimental sample of pooled human serum.
Кросс-линкинг роговичного коллагена в лечении трофических и бактериальных язв роговицы (2013)

The bacterial and trophic ulcers of cornea are an actual problem of modern ophthalmology. The severe outcomes in the form of persistent corneal caligo, length of courses of therapeutic treatment without persevering remission, development of such severe complications as perforation substantiate the search of new methods of treatment of the mentioned pathology.
WHEELCHAIR POWER OUTPUT DURING REHABILITATION OF PEOPLE WITH A SPINAL CORD INJURY (2003)

Maximal power output (POmax) during wheelchair propulsion is assumed to be a functional measure of physical capacity in persons with a spinal cord injury (SCI) and a relevant outcome measure of clinical rehabilitation. PURPOSE To investigate changes in, and determinants of wheelchair power output during SCI rehabilitation. METHOD Within the framework of a Dutch multi-center prospective cohort study, 69 subjects with SCI (17 subjects with tetraplegia) were investigated at the start of active rehabilitation (t1), 3 months later (t2) and at the end of clinical rehabilitation (t3). POmax was measured in a maximal wheelchair exercise test on a treadmill. Lesion level, age, gender, wearing a halo or corset during initial rehabilitation, time since injury at t1, and time between t1 and t3, were used as independent variables in a multiple regression analysis. RESULTS Time between t1 and t3 was 168±74 days. POmax increased significantly between t1 and t3 (14.2±13.6W, p < 0.001). Mean improvements were larger between t1 and t2 (11.2±11.4W) than between t2 and t3 (5.3±8.0W). Lesion level, gender, time between t1-t3, and age were significant determinants of POmax at t3, showing higher values with a lower lesion level, being male, a shorter time between t1-t3, and a younger age, thus explaining 66% of the variance. Changes in absolute POmax between t1-t3 were related to age and gender, showing larger improvements in younger and male subjects, explaining 21% of the variance. Changes in POmax between t1 and t3 expressed as percentage of POmax at t1 (55±58%) were related to age and lesion level, showing larger improvements in subjects with younger age and higher lesions levels (20% of the variance explained). Absolute and relative changes in POmax between t1 and t2 showed no significant relationships. CONCLUSIONS Results showed that improvements in POmax were larger during the first months of rehabilitation. Older persons and woman showed smaller absolute improvements, while relative improvements were larger in subjects with higher lesion levels. Future analysis will be performed to investigate other possible determinants of changes in POmax.
Immunoassay for Detection of Infliximab in Whole Blood Using a Fiber-Optic Surface Plasmon Resonance Biosensor (2017)

Monitoring the concentration of a therapeutic drug antibody, infliximab (IFX), is recommended for enhancing its efficacy in patients with inflammatory bowel disease (IBD). However, IFX concentrations are currently determined in patients' serum/plasma, which requires sample preparation from blood, hence hampering the turnaround time. In this paper, we present a short immunoassay (10 min) using a fiber-optic surface plasmon resonance (FO-SPR) biosensor for detection of IFX spiked in 100-fold diluted serum, plasma, and whole blood. The calculated limits of detection (LOD) based on calibration curves were 1.42, 1.00, and 1.34 ng/mL, respectively, which coincides with expected IFX concentrations in diluted samples from IBD patients. A linear correlation was established among different matrixes, indicating that the matrix effect was insignificant. The established point-of-care (POC) FO-SPR bioassay was also used to measure IFX in 100-fold diluted extracts of dried blood spots (DBS), and LOD achieved was below 2 ng/mL. Although DBS might be ideal for POC, this is the first report of using an SPR biosensor for measuring DBS samples. Finally, the POC FO-SPR immunoassay was validated by using matching serum and plasma samples from five IBD patients. A Pearson correlation of 0.968 was obtained between serum and plasma samples. IFX concentrations determined with FO-SPR were compared to a clinically validated enzyme-linked immunosorbent assay (ELISA), resulting in excellent Pearson correlation and intraclass correlation coefficient, both being 0.99 for serum and plasma samples. In conclusion, this paper demonstrates that our FO-SPR biosensor can be used as a true POC diagnostic tool for determining IFX concentrations in a variety of matrixes.
An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding (2010)

Previously, we have demonstrated that the tyrosine phosphorylated hepatocyte growth factor receptor (Met) binds to the c-Cbl phosphotyrosine-recognition, tyrosine kinase binding (TKB) domain in a reverse orientation compared to other c-Cbl binding partners. A Met peptide with the DpYR motif changed to RpYD (MetRD) retains a similar TKB binding affinity as the native Met peptide. However, the TKB: MetRD complex crystal structure reveals a complete reversal of the binding orientation. Collated data indicates that both binding and orientation is dictated by the phosphorylated tyrosine and an adjacent arginine forming intra-peptide hydrogen bonds and aligning unidirectionally with complementary charges in the phosphotyrosine binding pocket of c-Cbl.
Plasmonic nanoparticles, gain media and loss compensation (2011)

The resonant behaviour of single plasmonic nanoparticles in contact with gain media is studied theoretically, with a focus on the issue of loss compensation, resonance amplification and modification. Two approaches are presented. The first description is macroscopic and based on a simple, quasi-static continuum description of the gain medium, and shows that gain-assisted particle display unusual plasmonic responses, with features depending notably on the nature of the metal used (gold or silver). Results are discussed in two geometries, metallic nanoparticles in an infinite gain medium, and metal core-gain shell nanoparticles. The second model is microscopic and describes the situation of a metallic gold nanoparticle, surrounded with a corona of dye molecules or nanocrystals. A full analytical electromagnetic model is proposed, taking into account interactions, through a Green function formalism, between dye and particle, and also between dye and dye, both directly and mediated via the nanoparticle. The modes of the particle-and-dye system are studied, demonstrating that some modes, either emissive or absorptive, can be strongly amplified and dominate the response of the ensemble.
In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure (2021)

We identify a novel, potent, and orally bioavailable nonpeptidic APJ agonist that closely recapitulates the signaling properties of (Pyr<sup>1</sup>) apelin-13. We show that oral APJ agonist administration induces a sustained increase in cardiac output in the cardiac disease setting and exhibits a differentiated profile from the renin-angiotensin system inhibitor enalapril, supporting further clinical evaluation of BMS-986224 in heart failure.
Analysis of the secondary and tertiary structures of Rous sarcoma virus RNA (1980)

The secondary and tertiary structures of the 35S RNA of Rous Sarcoma virus have been investigated. T1 RNase partial digests have been first resolved into their components by gel electrophoresis under non denaturing conditions and then each component analyzed further by various techniques. More than one hundred structured fragments have thus been isolated and shown to consist of several individual nucleotide sequences located far apart on the genome. On the basis of the results, a cloverleaf model for the structure of RSV 35S RNA is proposed that has implications for the various biological functions of this RNA.
Effect of lithium cationization on oxygen atom transfer from the nitro group to the double bond during collision-induced decomposition in certain substituted β-nitrostyrenes (1997)

Fast-atom bombardment mass spectra of β-nitrostyrene derivatives give rise to abundant M+. and [M + H]+ ions and exhibit a fragmentation pattern attributable to the presence of a nitro group. Collision-induced decomposition (CID) of their [M + H]+ ions reveals an additional fragmentation involving oxygen migration to the double bond and leading to the protonated aldehyde. This oxygen migration is the predominant process in the CID of the [M + Li]+ adducts which exhibit ions corresponding to the lithiated aldehyde and to elimination of the neutral aldehyde. © 1997 John Wiley & Sons, Ltd.