gebhart/patrepeval huggingface dataset:
Predictive hyperglycemia and hypoglycemia minimization: In‐home double‐blind randomized controlled evaluation in children and young adolescents (2017)

The PHHM system was effective in optimizing overnight glycemic control, significantly increasing time in range, lowering mean glucose, and decreasing glycemic variability compared to PLGS alone in children 6 to 14 years old.
<title>Role Of Adaptive Operators In Image Understanding</title> (1982)

A system that hopes to accomplish robust automatic Image Understanding (IU) clearly needs techniques which can reason about what it is seeing and what it is trying to see. One need for reasoning is found in the ubiquitous operator parameter problem: the problem of setting parameters for low-level image computations. This paper explores this problem in the context of a complete IU system and presents an approach by which parameters are tuned with respect to high level features. Adaptive Operators accomplish this tuning by using 1) evaluations derived from specific object level features that rate the "goodness" of a segmented region; and 2) search methods which adaptively search for segmentation parameters producing the best region according to the evaluation. Adaptive Operators represent reasoning which ties together both the high-level, generally a-priori knowledge of an IU system and the lowest, purely computational level. Examples of Adaptive Operators and their performance are given in the context of a system to recognize buildings in aerial photographs.
Left ear dichotic suppression following partial callosal section (1976)

CV syllables (kindly provided by Kresge, LSU) were presented dichotically to a 13-year-old boy prior to and post surgical section of the majority of his corpus callosum. Pre-operatively no ear advantage was observed; however, after callosal section a clear right ear superiority emerged. Correct performance approximately doubled for the right ear and fell to change for the left ear. Voiceless CV's were reported correct more often than voiced, both prior to and post surgery. In addition, alveolars were more often reported correctly than labials, which in turn are reported more correct than velars. His single correct response performance was highest when pairs shared voicing preoperative and lowest when pairs shared place. Postoperatively sharing place still resulted in the lowest percent correct; however, performance was highest when pairs shared neither place nor voice. An analysis of pairs resulting in errors revealed that for the (1) voiceless/voiceless condition 16.6% errors occurred pre; and postoperatively, (2) voiced/voiced condition 21.0% errors occurred preop and 25.0% postop.; (3) voiceless/voiced condition 64.4% errors occurred preop and 58.4% postop. Thus error pattern did not change after section. These data suggest that callosal section results in suppression of the ear countralateral to the speech processor by removing the interhemisphere relay route.
Control of Stomatal Distribution on the <i>Arabidopsis</i> Leaf Surface (2002)

Stomata regulate gas exchange and are distributed across the leaf epidermis with characteristic spacing. Arabidopsis stomata are produced by asymmetric cell divisions. Mutations in the gene TOO MANY MOUTHS (TMM) disrupt patterning by randomizing the plane of formative asymmetric divisions and by permitting ectopic divisions. TMM encodes a leucine-rich repeat-containing receptor-like protein expressed in proliferative postprotodermal cells. TMM appears to function in a position-dependent signaling pathway that controls the plane of patterning divisions as well as the balance between stem cell renewal and differentiation in stomatal and epidermal development.
Terpenoids. XLIX.<sup>1</sup> Preparation of Optically Active Polyalkylcyclohexanones from (+)-Pulegone, (-)-Menthone and (-)-Carvone<sup>2</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTerpenoids. XLIX.1 Preparation of Optically Active Polyalkylcyclohexanones from (+)-Pulegone, (-)-Menthone and (-)-Carvone2Carl Djerassi, J. Osiecki, and E. J. EisenbraunCite this: J. Am. Chem. Soc. 1961, 83, 21, 4433–4439Publication Date (Print):November 1, 1961Publication History Published online1 May 2002Published inissue 1 November 1961https://doi.org/10.1021/ja01482a032RIGHTS & PERMISSIONSArticle Views382Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (937 KB) Get e-Alerts Get e-Alerts
Growth of {100}-faceted NaFeTiO<sub>4</sub> crystals with a tunable aspect ratio from a NaCl–Na<sub>2</sub>SO<sub>4</sub> binary flux (2017)

The controlled growth of NaFeTiO<sub>4</sub> crystals with needle and planar bar shapes from a NaCl–Na<sub>2</sub>SO<sub>4</sub> binary flux with different compositions.
Nonlinear Chiroptical Response of GaAs Nanowires Partially Covered by Au (2019)

The light interacting on asymmetric nanostructures can give rise to the phenomenon called extrinsic chirality [1-3], even if the nanostructures are not chiral by themselves. In this cases, light can be manipulated in order to obtain interesting behaviour such as anomalous refraction [4] or circular dichroism [5].
Characterization of Human Salivary Extracellular RNA by Next-generation Sequencing (2018)

Our results may help in selection of the best adapted methods of RNA isolation and small and long RNA library constructions for salivary exRNA studies.
Mickey: a macro cell global router (2002)

The authors present a new graph-based macro cell global router. The placement of the macro cells need not have the slicing structure and the macro cells may have any rectilinear shape. A key contribution is a new algorithm which efficiently generates M shortest routes for every net. The global router then selects one route for each net while seeking to avoid the net routing-order dependence problem. Mickey has two different objective functions, making it applicable to different design styles. It can be used to either minimize the chip area or to minimize the total wire length under channel capacity constraints. Test results on industrial circuits show that Mickey outperforms existing approaches.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pentacoordinate Ruthenium(II) Catecholthiolate and Mercaptophenolate Catalysts for Olefin Metathesis: Anionic Ligand Exchange and Ease of Initiation (2016)

The investigations disclosed offer insight regarding several key features of Ru-based catecholthiolate olefin metathesis catalysts. Factors influencing the facility with which the two anionic ligands undergo exchange and those that affect the rates of catalyst release are elucidated by examination of more than a dozen new complexes. These studies shed light on how different chelating groups can influence Ru–S bond strength and, as a result, the facility of catecholthiolate rotation. The trans influence series ether < ester ≈ iodide < amine ≈ thioether ≈ olefin < isonitrile ≈ phosphite has been established through X-ray structural analysis and shown to correlate well with the barrier for catecholthiolate rotation (trans effect) determined by variable-temperature NMR experiments and computational studies (DFT). It is found that, apart from electronic factors, chelate geometry has a more notable effect on the rate of catalyst release (five- vs six-membered chelate ring and mono- vs bidentate ligand). Polytopal processes involving pentacoordinate Ru(II) carbene complexes are shown to be distinct from previously reported fluxional events that involve tetracoordinate species and which are capable of causing diminished polymer syndiotacticity. Ru mercaptophenolate complexes have been synthesized and isolated as a single diastereomer (O–C trans to the NHC). This latter set of species promotes representative olefin metathesis reactions readily and gives Z selectivity levels that are higher than those when the corresponding catecholate systems are used, but less so in comparison to catecholthiolate complexes. A rationale for variations in stereoselectivity is presented.
A thermal accelerometer directly integrated on organic substrate (2011)

A thermal accelerometer was developed and evaluated. The presented device was fabricated directly on an organic substrate, which ensures a high level of thermal isolation, while also facilitating direct electrical communication to the macroworld. The role of the seismic mass was utilized by a fluid (water), which was confined in a tank adjusted on the sensor surface. Acceleration quantification is achieved by the monitoring of the cooling effect on the heating element. A sensor signal of 32 mV for an acceleration of 1 g was obtained.
Výtvarná koncepce filmu dle scénáře "Leopold III. musí zmizet", příklady výtvarného řešení žánru filmové parodie a crazy komedie v českém a světovém filmu (2010)

This Diploma Project is focused on the Phenomenon of Czech and French Movie ?Crazy Comedies? from Sixties and Seventies ? In Light of Set Design Treatment. Special Emphasis is put on Those with Parody Character and Those which creates Their Own Fictive World ? Like Nonexistent States and Fancied Locations.\n\nThe Project includes the Artwork Proposal - Set Design for New Movie with Retro-Style Related to Above-Mentioned Movie Production.
Fairness issues in peer-to-peer networks (2003)

This paper considers the issue of fairness arising from peer-to-peer networks. Various concepts of fairness are proposed. In particular, it is shown that the issue of having a perfectly fair solution is related to a generalization of the Perron-Frobenius theorem. The fairness issue also leads questions whether there exist distributed feedback control algorithms that converge to the desired optimal or feasible states. These control algorithms possess the following characteristics. First of all, the controllers are numerous and are highly distributed. Secondly, controls are based on limited feedback information. Finally, network parameters are mostly unknown; hence these controllers should be robust. A class of controllers satisfying these characteristics is presented and their applicability of the fairness problem is discussed.
A new informant‐based questionnaire for instrumental activities of daily living in dementia (2012)

The Amsterdam IADL Questionnaire (Amsterdam IADL questionnaire is a registered trademark of Alzheimer Center VU University Medical Center, Amsterdam, The Netherlands) is a 70-item informant-based computerized questionnaire aimed at detecting early dementia and early-onset dementia. Initial results show that this questionnaire is a promising new tool.
Cotranscriptional effect of a premature termination codon revealed by live-cell imaging (2011)

Aberrant mRNAs with premature translation termination codons (PTCs) are recognized and eliminated by the nonsense-mediated mRNA decay (NMD) pathway in eukaryotes. We employed a novel live-cell imaging approach to investigate the kinetics of mRNA synthesis and release at the transcription site of PTC-containing (PTC+) and PTC-free (PTC-) immunoglobulin-μ reporter genes. Fluorescence recovery after photobleaching (FRAP) and photoconversion analyses revealed that PTC+ transcripts are specifically retained at the transcription site. Remarkably, the retained PTC+ transcripts are mainly unspliced, and this RNA retention is dependent upon two important NMD factors, UPF1 and SMG6, since their depletion led to the release of the PTC+ transcripts. Finally, ChIP analysis showed a physical association of UPF1 and SMG6 with both the PTC+ and the PTC- reporter genes in vivo. Collectively, our data support a mechanism for regulation of PTC+ transcripts at the transcription site.
Protection of Mouse Islet Isografts from Nonspecific Inflammatory Damage by Recipient Treatment with Nicotinamide and 15-Deoxyspergualin (1996)

The major cause of primary nonfunction of transplanted islets is nonspecific inflammation associated with the transplantation procedures. Using mouse islet isografts, we attempted to prevent graft loss mediated by nonspecific inflammation using recipient treatment with nicotinamide (NA) and 15-deoxyspergualin (DSG). Newborn BALB/c islets, ranging in numbers between 1200 and 1500, were transplanted into syngeneic adult mice made diabetic by intravenous injection of 200 mg/kg streptozotocin. Recipient mice were divided into the following four groups, based on the treatment protocol of NA and DSG: intraperitoneal injection (IP) of normal saline (Group 1), IP injection of 2500 mg/kg NA (Group 2), IP injection of 5 mg/kg DSG (Group 3), and IP injection of NA + DSG (Group 4). Treatment started Day -1 and continued until Day 9 (Day 0 is day of transplantation). Blood and urine glucose, body weight, and intravenous glucose tolerance tests (IV-GTT) were examined after transplantation. Reversal of diabetes, as indicated by normoglycemia and negative urine glucose, was higher in Groups 2 (75%), 3 (50%), and 4 (85.7%), compared to Group 1 (11.1%). Especially in Group 4, the endocrine function and morphology of grafted islets were well preserved as shown by K values of IV-GTT and histological studies. These results suggest the importance of islet protection from irreversible damage by nonspecific inflammation at earlier stages of implantation, and the effectiveness of a short course of treatment with NA and DSG.
Efficacy and Safety of Daptomycin in Patients with Renal Impairment: A Multicenter Retrospective Analysis (2014)

Daptomycin demonstrated clinical and microbiologic success rates comparable with prior studies. Discontinuation of therapy because of elevated CPK levels may have been avoided in some patients with adjustment to every 48-hour dosing for Clcr less than 30 ml/minute. The relatively early time to onset suggests the need for CPK monitoring more frequently than once/week in renally impaired patients receiving daptomycin. The treatment of bacteremia in patients with renal insufficiency warrants further study.
Anti-apoptotic effects of Notch-1 in cervical cancer cells are mediated by NF-κB and AKT (2004)

5008 Activation of Notch receptors mediates survival signals in cells from various solid tumors. We have previously shown that pharmacological or genetic silencing of Notch-1 signaling effectively induced apoptosis and significantly enhanced the cytotoxic effects of various anti-neoplastic agents acting in S, G2 or M phases of the cell cycle. We have also demonstrated that inhibition of Notch-1 expression or activity has dramatic anti-neoplastic effects in vitro and in vivo. However, the mechanism(s) of Notch-induced survival signals remain unclear. Activation of NF-κB and AKT and inhibition of JNK by constitutively active Notch-1 have been described in some models. We studied the mechanism of survival signals induced by Notch-1 in cervical cancer CaSki cells, which are unable to grow in vitro or form tumors in vivo when transduced with antisense Notch-1. We found that blocking Notch activation with a gamma-secretase inhibitor (GSI) caused dose-dependent cell death in CaSki cells. Expression of intracellular (constitutively active) Notch-1 (ICN) protected cells from this effect. GSI also caused dose-dependent inhibition of NF-κB reporter activity, which was diminished when the cells were transfected with ICN. NF-κB inhibition was also observed after specific silencing of Notch-1 expression by siRNA. AKT has been reported to be downstream of Notch-1 and can induce NF-κB activation by phosphorylating IKK (I-κB kinase). Consistent with this, our data show that NF-κB activity was strongly activated in CaSki cells transfected with constitutively active AKT. Notch-1 upregulated the phosphorylation but not the total level of AKT in CaSki cells. Silencing Notch-1 signaling led to down-regulation of pAKT and inhibition of NF-κB. JNK phosphorylation was increased in CaSki nuclear extracts after GSI treatment. However, JNK inhibitory drugs did not prevent GSI-induced apoptosis, suggesting that JNK does not play a central role in cell death induced by GSI. Taken together, our data support a model in which Notch-1 exerts its anti-apoptotic functions in cervical cancer cells by activating NF-κB transcription factors via the PKB-AKT pathway. Our data support the investigational use of combinations of GSIs or other Notch inhibitors with AKT inhibitors and/or NF-κB inhibitors for the treatment of advanced cervical cancer. (Supported by NIH grant CA84065)
Temporally regulated assembly of a dynamic signaling complex associated with the activated TCR (2000)

TCR triggering promotes multiple tyrosine kinase-dependent interactions involving proteins with one or more protein binding modules. Reported interactions mostly exceed the binding potential of these proteins. A solution to this paradox is the temporally regulated recruitment of alternative ligands. We have tested this hypothesis by analyzing the time course of protein/protein interactions triggered by TCR engagement. We show that a short-lived and dynamic multimolecular complex is assembled on tyrosine-phosphorylated CD3zeta. Specific components of this complex are recruited and shed in a temporal sequence distinct for each of the proteins analyzed. The temporally regulated assembly of a higher order structure at the activated TCR is likely to be crucial in achieving both signal longevity and signal specificity.
Binding of apolipoprotein A-I and apolipoprotein A-IV to cultured bovine aortic endothelial cells. (1988)

Adult bovine aortic endothelial (ABAE) cells specifically bound 125I-labelled high density lipoprotein3 (125I-HDL3), and saturation of the binding was observed at a concentration of about 50 to 100 micrograms protein/ml. The binding of purified apolipoproteins (apo) A-I and A-IV to cultured ABAE cells and the correlation of this binding with the binding of HDL to the cells was studied. ABAE cells bound 125I-labelled apo A-I (125I-apo A-I) and after a 3-hour exposure to the ligand, most of the radioactivity (82%) was associated with the cell surface and was accessible for trypsinization. Saturation of 125I-apo A-I binding was observed at a concentration of 3 micrograms/ml; each cell possessed 1.38 X 10(5) high affinity binding sites (Kd = 2.04 X 10(-8) M). The cultures also bound 125I-labelled apo A-IV (125I-apo A-IV), and saturation of the binding was observed at a concentration of 2 micrograms/ml. Each cell possessed 5.4 X 10(4) high affinity binding sites for apo A-IV (Kd = 1.45 X 10(-8) M). Addition of either excess unlabelled apo A-I or excess unlabelled apo A-IV competed with the binding of both iodinated apo A-I and apo A-IV. It suggests that apo A-I and A-IV share the same binding site on endothelial cells. HDL also successfully competed with the binding of apo A-I and A-IV to ABAE cells.(ABSTRACT TRUNCATED AT 250 WORDS)
Enzyme-Linked Immunosorbent Assay for Microcystins in Blue-Green Algal Blooms (1990)

A direct competitive enzyme-linked immunosorbent assay (ELISA) for the freshwater blue-green algal toxin microcystin (MCYST) in algae and water was developed. The assay involves coating anti-MCYST-variant leucine-arginine (LR) antibody to the ELISA plate and the use of MCYST-LR-peroxidase as the enzyme marker. The linear portion of the standard curve for MCYST in phosphate buffer containing saline (PBS) was 0.5-10.0 ng/mL (25-500 pg/assay). The minimum detection level for MCYST-LR was 0.20 ng/mL (10 pg/assay). Contaminated water could be directly used in the ELISA. The overall analytical recoveries for MCYST-LR added to water at levels of 1-20 ng/mL was 83.4%. For analysis of cellular MCYST, the toxin was first extracted from the algae with 0.1M ammonium bicarbonate, diluted with PBS to less than 0.5 mg dried algae/mL (less than 5.0 mg wet weight/mL) and directly used in the ELISA. C-18 reverse-phase Sep-Pak cartridges effectively adsorbed MCYST from the toxin-containing solutions. The toxin could be recovered from the cartridge by eluting with 60% methanol. Using this approach, an algae extract that was relatively free of MCYST was prepared and was used in a recovery study. The overall analytical recovery of MCYST added to the algae extract in the range of 0.25-20 ppm was 83% with a coefficient of variation of 11.9%. The detection limit for MCYST in dried algae was about 0.25-0.5 microgram/g (0.25-0.5 ppm) lyophilized algae sample. This method was applied for the analysis of several naturally occurring algal blooms. Limited samples were also analyzed for MYCST by liquid chromatography.(ABSTRACT TRUNCATED AT 250 WORDS)
FACTORS IN THE DESIGN OF NUCLEAR MAGNETIC RESONANCE IMAGING AGENTS (1984)

Hoey, G. B.; Adams, M. D.; Robbins, M. S.; Dean, R. T.; White, D. H.; Rizzolo, R. R.; Monzyk, M. A.; Bosworth, M. E.; Wolf, G. L.
Local Anaesthetic Activity of Monoterpenes and Phenylpropanes of Essential Oils (2001)

The local anaesthetic activity of a number of compounds with different structures, contained in essential oils, was studied. Anaesthetic activity was evaluated in vivo in the rabbit conjunctival reflex test and in vitro in a rat phrenic nerve-hemidiaphragm technique. Among the substances tested terpineol and trans-anethole (10(-3) - 1 microg/ml) were able to drastically reduce the electrically evoked contractions of rat phrenic nerve-hemidiaphragm in a concentration-dependent manner, but not eugenol, (-)- and (+)-citronellal, (-)- and (+)-carvone, trans cinnamaldehyde and alpha-terpinene. In the rabbit conjunctival reflex test, the treatment with a solution of terpineol and trans-anethole (10 - 100 microg/ml) effected a concentration-dependent increase in the number of stimuli required to evoke the reflex, thus confirming in vivo the local anaesthetic activity observed in vitro. Eugenol, (-)- and (+)-citronellal, trans-cinnamaldehyde, (-)- and (+)-carvone and alpha-terpinene were as ineffective in the in vivo test as they were in the in vitro results.
A42 VALIDATION OF A SIMPLIFIED METHOD FOR THE DETERMINATION OF RADIOCHEMICAL PURITY OF 99MTC-MAG3 (2005)

aPharmaceutical Quality Assurance bNuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK Abstracts of the spring 2005 meeting of the British Nuclear Medicine Society Manchester International Convention Centre, UK; 14–16 March, 2005