gebhart/patrepeval huggingface dataset:
SPOUTED BED DRYING OF SLUDGE FROM METALS FINISHING INDUSTRIES WASTEWATER TREATMENT PLANTS (1993)

ABSTRACT A 0.15 m diameter half cylindrical spouted bed was used to dry a ferric hydroxide - zinc hydroxide sludge with a moisture content of 83.4 % wet basis. Heat for drying was provided by an electrical air preheater. The sludge was fed through an air cooled feeder into the spout and dried product was removed by elutriation; it was captured by a cyclone and baghouse. The mechanisms of drying and the performance of the drier were studied as a function of the operating variables. A glass front panel was used for visual observation of the system to elucidate the drying mechanisms, a stainless steel panel was used at other times. The study showed that a spouted bed drier could produce a consistent fine powder product with a mechanically simple and reliable design. A cost comparison of a spouted bed with other driers for a typical metals finishing installation shows that the spouted bed is cost competitive with conventional technology.
A Depth Scanning Microscope (1971)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. C. King and D. H. Berry, "A Depth Scanning Microscope," Appl. Opt. 10, 208-210 (1971) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Detection, tracking and classification of moving objects for unstable video surveillance applications (2008)

Detecting, tracking, and classifying moving objects using a single fixed camera is quickly becoming commonplace in many applications ranging from advanced traffic monitoring systems to security applications including border monitoring. In this paper, we present a framework for the detection, tracking, and classification of moving objects in an unstable video taken of a traffic intersection in India. Combinations of methods have been implemented in an attempt to successfully perform the aforementioned tasks automatically. An initial evaluation of these methods is discussed and compared to preliminary results from a manually segmented video.
THE MECHANISM OF VIRUS ATTACHMENT TO HOST CELLS. III<sup>1</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE MECHANISM OF VIRUS ATTACHMENT TO HOST CELLS. III1L. J. Tolmach and T. T. PuckCite this: J. Am. Chem. Soc. 1952, 74, 21, 5551–5553Publication Date (Print):November 1, 1952Publication History Published online1 May 2002Published inissue 1 November 1952https://pubs.acs.org/doi/10.1021/ja01141a539https://doi.org/10.1021/ja01141a539research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cyclization dynamics of polymers. 20. Excluded volume effects on the end-to-end cyclization of polystyrene in mixed solvents (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclization dynamics of polymers. 20. Excluded volume effects on the end-to-end cyclization of polystyrene in mixed solventsJ. M. G. Martinho and Mitchell A. WinnikCite this: Macromolecules 1986, 19, 8, 2281–2284Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://doi.org/10.1021/ma00162a029RIGHTS & PERMISSIONSArticle Views74Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (470 KB) Get e-Alerts Get e-Alerts
Approaches to prevention and treatment of drug allergy (1979)

The problem of allergic reactions to drugs continues to plague patients, physicians and drug manufacturers. Most drug-monitoring studies record about 10 to 15 per cent untoward reactions of hospitalised patients to one or the other drug administered to them; among these 40 to 50 per cent are felt to be of allergic nature (Klein et al., 1972), which leaves us with an overall incidence of about 5 per cent of allergic reactions to drugs in a population of hospitalised patients.
The feasibility of replacing or upgrading utility distribution transformers during routine maintenance (1995)

It is estimated that electric utilities use about 40 million distribution transformers in supplying electricity to customers in the United States. Although utility distribution transformers collectively have a high average efficiency, they account for approximately 61 billion kWh of the 229 billion kWh of energy lost annually in the delivery of electricity. Distribution transformers are being replaced over time by new, more efficient, lower-loss units during routine utility maintenance of power distribution systems. Maintenance is typically not performed on units in service. However, units removed from service with appreciable remaining life are often refurbished and returned to stock. Distribution transformers may be removed from service for many reasons, including failure, over- or underloading, or line upgrades such as voltage changes or rerouting. When distribution transformers are removed from service, a decision must be made whether to dispose of the transformer and purchase a lower-loss replacement or to refurbish the transformer and return it to stock for future use. This report contains findings and recommendations on replacing utility distribution transformers during routine maintenance, which is required by section 124(c) of the Energy Policy Act of 1992. The objectives of the study are to evaluate the practicability, cost-effectiveness, and potential energy savings of replacing or upgrading existing transformers during routine utility maintenance and to develop recommendations on was to achieve the potential energy savings.
Proteomics gives insight into the regulatory function of chloroplast thioredoxins (2002)

Thioredoxins are small multifunctional redox active proteins widely if not universally distributed among living organisms. In chloroplasts, two types of thioredoxins (f and m) coexist and play central roles in regulating enzyme activity. Reduction of thioredoxins in chloroplasts is catalyzed by an iron-sulfur disulfide enzyme, ferredoxin-thioredoxin reductase, that receives photosynthetic electrons from ferredoxin, thereby providing a link between light and enzyme activity. Chloroplast thioredoxins function in the regulation of the Calvin cycle and associated processes. However, the relatively small number of known thioredoxin-linked proteins (about 16) raised the possibility that others remain to be identified. To pursue this opportunity, we have mutated thioredoxins f and m, such that the buried cysteine of the active disulfide has been replaced by serine or alanine, and bound them to affinity columns to trap target proteins of chloroplast stroma. The covalently linked proteins were eluted with DTT, separated on gels, and identified by mass spectrometry. This approach led to the identification of 15 potential targets that function in 10 chloroplast processes not known to be thioredoxin linked. Included are proteins that seem to function in plastid-to-nucleus signaling and in a previously unrecognized type of oxidative regulation. Approximately two-thirds of these targets contained conserved cysteines. We also identified 11 previously unknown and 9 confirmed target proteins that are members of pathways known to be regulated by thioredoxin. In contrast to results with individual enzyme assays, specificity for thioredoxin f or m was not observed on affinity chromatography.
Analyses of temperature influence in piezoelectric transformers dedicated to plasma generation (2015)

This paper deals with the study of the operating frequency variation in piezoelectric plasma generator. The analysis relies on experimental investigations of transformers driven with a digital phase locked loop. The frequency shift attests of simultaneous effects of plasma load and the rise of temperature. Several tests are shown to highlight and distinguish these effects.
Downregulated in adenoma gene encodes a chloride transporter defective in congenital chloride diarrhea (1999)

Congenital chloride diarrhea (CLD) is a recessively inherited disorder characterized by massive loss of chloride in stool. We previously identified mutations in the downregulated in adenoma (DRA) gene in patients with CLD and demonstrated that DRA encodes an intestine-specific sulfate transporter. To determine whether DRA is an intestinal chloride transporter and how mutations affect transport, Xenopus oocytes were injected with wild-type and mutagenized DRA cRNA and uptake of Cl- and SO2-4 was assayed. Both Cl- and SO2-4 were transported by wild-type DRA and an outwardly directed pH gradient stimulated Cl- uptake, consistent with Cl-/OH- exchange. Among three mutants, C307W transported both anions as effectively as wild-type, whereas transport activity was lost in V317del and the double mutant identified in 32 of 32 Finnish CLD patients. We conclude that DRA is a chloride transporter defective in CLD and that V317del is a functional mutation and C307W a silent polymorphism.
Convertir el área de finanzas en socio estratégico (2008)

Teniendo en cuenta la cantidad de tiempo, dinero y esfuerzo invertidos, puede llegar incluso a plantearse la posibilidad de que el abismo que separa las finanzas de las operaciones sea insalvable. El autor de este articulo considera que, paradojicamente, el area de finanzas tiene justo delante el vinculo existente entre esta area y la de explotacion: es la asignacion de recursos.
Clinical and microbial factors associated with clinically diagnosed infection in chronic leg ulcers (2017)

Background: Wound infection results in delayed wound healing. The development of infection in chronic wounds can be influenced by many factors that impair the host’s ability to defend or related to the bacterial ability to cause harm. These factors can be comorbidities, psychosocial factors, the bacterial virulence, bacterial load or microbial synergy. This study explored the factors related to the likelihood of the development of infection in participants with chronic leg ulcers...
Kinetic studies of the active sites functioning in the quinohemoprotein fructose dehydrogenase (1993)

Steady-state kinetic analysis was performed on the reaction between D-fructose and ferricyanide with the quinohemoprotein fructose dehydrogenase from Gluconobacter species. The D-fructose oxidation dependence on the ferricyanide concentration resulted in a series of parallel reciprocal plots, and the reaction was assumed to proceed by a ping-pong type of mechanism. A reciprocal plot of the reduction of ferricyanide at saturating concentration of D-fructose gave a break which was considered to appear as a result of the two active centers, namely PQQ and heme c functioning. A scheme of action is proposed and the bimolecular rate constant of the D-fructose oxidation, the kcat for PQQ and the electron transfer rate between the PQQH2 and heme c are calculated and account for 2.2 +/- 0.4 x 10(4) M-1 s-1, (93 +/- 14) and (162 +/- 7) s-1, respectively.
Gastrin-releasing peptide receptor antagonist induces a protection from lethal sepsis: involvement of toll-like receptor 4 signaling (2010)

In 2002, the Surviving Sepsis Campaign defi ned a strategy that aimed to reduce the high mortality due to sepsis. One point of this strategy was a recommendation to recognize that sepsis is a frequent cause of death and high economic costs in the pediatric intensive care unit. Knowledge of the disease is the fi rst step to impact it. There are few studies on pediatric sepsis epidemiology in the world and none in Colombia. Hypothesis The epidemiological features of Colombian children are diff erent from other countries. Methods We constructed a website where 14 intensive care units across the country reported in a prospective way the epidemiological features of children with sepsis using an electronic process [1]. We asked for sociodemographics, microbiological data, sepsis classifi cation, complications, and outcome.
Target Grounding Requirements for Electrostatic Deposition of Pesticide Sprays (1989)

ABSTRACT During the typical 600 ms - 1 s electrostatic crop-spraying event, the flow of transient current to earth is required if electrodeposition is to occur unimpeded. Theoretically, it is shown that target charge-dissipation time constants RC < 0.1 s should facilitate adequate grounding for this process. Experimental analysis of a 120 pF spray target, simulating plastic-potted greenhouse plants, confirmed that the 5-fold increase in charged vs. uncharged droplet deposition did not significantly depend upon the resistance imposed in the grounding path over a 0 - 10^^ ohm range. A survey of hanging and table-supported plastic-containerized living plants in commercial greenhouses indicated plant-to-earth resistances of 10^ - 10^ ohms. Electrical grounding of such plants should be adequate for satisfactory development of electrostatic crop-spraying for greenhouse culture.
P114 The influence of obesity on clinical course and behaviour of Crohn's disease (2014)

Clinical: Diagnosis & outcome S109 reactive protein-CRP etc.) factors, FC and fecal MMP-9. IBD patients in remission were selected as a control group. Results: 90 IBD patients with relapse were enrolled in our study (male/female: 44/46, mean age: 36.68 years; CD/UC: 38/51). 49 subjects in clinical remission were enrolled in the control group. The mean values of CRP, leukocytes, FC and MMP-9 were 23.52 mg/l, 10.05 G/l, 1292.46 mg/g and 11.77 ng/ml in the relapsed group and 6.54 mg/l, 7.06 G/l, 216.11 mg/g, 3.46 ng/ml in the control group. The clinical activity indices showed mild and moderate disease activity: the mean value of CDAI was 227.9, and pMayo score was 5.2 points. 56.6% of patients had positive microbiological results. Clostridium difficile A and B toxin positivity was verified in 91% of the cases. Statistical analysis showed significant difference between FC and MMP-9 values in patients with relapse and remission, but not in Clostridium difficile positive and negative cases. Our results revealed an association between previous antibiotic use and Clostridium difficile positivity (p = 0.03). Conclusions: We suggest that the presence of Clostridium difficile is very frequent in flare-ups of IBD and it has an important role in the relapse, therefore the stool analysis is recommended in every relapse to optimize therapy. FC and MMP-9 has no diagnostic power to differentiate between infection-induced and natural relapse.
Characterization of a β-Asp33 Isoform of Recombinant Hirudin Sequence Variant 1 by Low-energy Collision-induced Dissociation (1996)

A new low-concentration congener (Ib) of recombinant hirudin sequence variation 1 was structurally characterized as a beta-Asp33 isoform of the parent protein (Ia). alpha-beta Isomerization at the 33-position was expected in view of the previous isolation of a potential precursor (Asp33-Gly34-anhydro-hirudin (Ic)), i.e., a succinimide-type dehydration product liable to undergo facile hydrolysis with ring opening, yielding beta- (along with alpha-) aspartates. In order to identify and locate the modified site in Ib, a sufficiently small peptide ([28-35]-octapeptide IIIb) was prepared by disulfide bond reduction, S-alkylation (pyridylethylation) and twofold enzymatic degradation (Glu-C protease followed by trypsin). When [M + H] + ions of IIIb were analyzed by electrospray ionization tandem mass spectrometry (ESIMS/MS) and low-energy collision-induced dissociation (CID), a singular [bn + H2O]+ ion indicative of beta-Asp in the neighboring 'n + 1' position was observed for n = 5. This located the beta-Asp residue unambiguously in the 6-position of IIIb and thus, as expected, in the 33-position of Ib. The formation of this highly diagnostic [bn + H2O]+ ion, for which precedents had only been reported for CID under high-energy conditions, requires net OH migration from one to another amino acid position. Confirmatory results from 18O-labeling of the suspected migratory oxygen atom (beta-Asp33-CO18OH) together with the low-energy genesis suggest a specific charge-triggered rather than charge-remote mechanism for the formation of the ion. The analogy of this process to the ejection of the C-terminal amino acid similarly involving net OH rearrangement is discussed.
Evidence-based support for prolonged glucocorticoid treatment in acute lung injury/acute respiratory distress syndrome (2010)

Departments of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center and Memphis Veterans Affairs Medical Center, Memphis, TN (Meduri) Université de Versailles SQY (UniverSud Paris), Garches, France (Annane) East Virginia Medical School, Norfolk, VA (Marik)
Citrate Sensing by the C <sub>4</sub> -Dicarboxylate/Citrate Sensor Kinase DcuS of <i>Escherichia coli</i> : Binding Site and Conversion of DcuS to a C <sub>4</sub> -Dicarboxylate- or Citrate-Specific Sensor (2007)

The histidine protein kinase DcuS of Escherichia coli senses C(4)-dicarboxylates and citrate by a periplasmic domain. The closely related sensor kinase CitA binds citrate, but no C(4)-dicarboxylates, by a homologous periplasmic domain. CitA is known to bind the three carboxylate and the hydroxyl groups of citrate by sites C1, C2, C3, and H. DcuS requires the same sites for C(4)-dicarboxylate sensing, but only C2 and C3 are highly conserved. It is shown here that sensing of citrate by DcuS required the same sites. Binding of citrate to DcuS, therefore, was similar to binding of C(4)-dicarboxylates but different from that of citrate binding in CitA. DcuS could be converted to a C(4)-dicarboxylate-specific sensor (DcuS(DC)) by mutating residues of sites C1 and C3 or of some DcuS-subtype specific residues. Mutations around site C1 aimed at increasing the size and accessibility of the site converted DcuS to a citrate-specific sensor (DcuS(Cit)). DcuS(DC) and DcuS(Cit) had complementary effector specificities and responded either to C(4)-dicarboxylates or to citrate and mesaconate. The results imply that DcuS binds citrate (similar to the C(4)-dicarboxylates) via the C(4)-dicarboxylate part of the molecule. Sites C2 and C3 are essential for binding of two carboxylic groups of citrate or of C(4)-dicarboxylates; sites C1 and H are required for other essential purposes.
Androgen Receptor Counteracts Doxorubicin-Induced Cardiotoxicity in Male Mice (2010)

has been used as a potent anticancer agent, but serious cardiotoxicity precludes its use in a wide range of patients. We have reported that the androgen-androgen receptor (AR) system plays important roles in cardiac growth and protection from angiotensin II-induced cardiac remodeling. The present study was undertaken to clarify whether the androgen-AR system exerts a cardioprotective effect against Dox-induced cardiotoxicity. Male AR knockout (ARKO) and age-matched littermate male wild-type (WT) mice at 25 wk of age were given ip injections of Dox (20 mg/kg) or a vehicle. The survival rate and left ventricular function in Dox-treated male ARKO mice were reduced compared with those in Dox-treated male WT mice. Electron microscopic study showed prominent vacuole formation of myocardial mitochondria in Dox-treated male ARKO mice. Cardiac oxidative stress and apoptosis of cardiomyocytes were increased more prominently by Dox treatment in male ARKO mice than in male WT mice. In addition, Dox-induced reduction in the expression of cardiac mitochondria transcription factor A (Tfam) and phosphorylation of serine-threonine kinase (Akt) was more pronounced in male ARKO mice than in male WT mice. In cardiac myoblast cells, testosterone up-regulated Akt phosphorylation and Tfam expression and exerted an antiapoptotic effect against Dox-induced cardiotoxicity. Collectively, the results demonstrate that Dox-induced cardiotoxicity is aggravated in male ARKO mice via exacerbation of mitochondrial damage and superoxide generation, leading to enhanced apoptosis of cardiomyocytes. Thus, the androgen-AR system is thought to counteract Dox-induced cardiotoxicity partly through activation of the Akt pathway and up-regulation of Tfam to protect cardiomyocytes from mitochondrial damage and apoptosis.
Network views for personalized medicine (2013)

Clinical Proteomics has traveled a long way pinpointing potential biomarkers for a variety of diseases. However, the absence of clinical implementation of proteomics findings has led to a frank evaluation and reconsideration of applied practices in biomarker discovery, recruitment of technological tools for biomarker verification and generation of new guidelines for data reporting. Nevertheless, considering the need for vast clinical resources for biomarker validation, the frequent lack of clear definitions of contexts of use, in combination to the biomarker "high offer," progress toward biomarker implementation will even more require the adoption of an extensive open-minded approach: disease-focused networks are needed to ensure rapid exchange of information, initiation of appropriate studies, parallel validation of multiple biomarkers and sharing of valuable clinical resources. This viewpoint article targets to reflect on these issues and advocates the added value of multidisciplinary networks in biomarker development using bladder cancer as a paradigm.