gebhart/patrepeval huggingface dataset:
Alternative Effects of the Ubiquitin-Proteasome Pathway on Glucocorticoid Receptor Down-Regulation and Transactivation Are Mediated by CHIP, an E3 Ligase (2005)

The ubiquitin/proteasome-dependent protein degradation pathway (UPP) is responsible for the accelerated down-regulation of glucocorticoid receptor (GR) levels in cells subjected to chronic glucocorticoid exposure. Whereas hormone-dependent down-regulation of GR operates in most cells, the receptor is not down-regulated after long-term glucocorticoid treatment of either cultured embryonic hippocampal neurons or the HT22 hippocampal cell line. In this report, we show that stable overexpression of the carboxy terminus of heat shock protein 70-interacting protein (CHIP) E3 ligase can restore hormone-dependent down-regulation of GR in HT22 cells. Proteasome inhibitor studies establish that ubiquitylated GR can be efficiently engaged with the proteasome upon CHIP overexpression, unlike the case in parental HT22 cells. In addition to its impact on GR down-regulation, CHIP overexpression alters the coupling between the UPP and GR transactivation. Unlike other steroid receptors whose transactivation properties are typically reduced upon proteasome inhibition, GR transactivation in HT22 cells and other cell lines is enhanced upon proteasome inhibition. However, in HT22 cells overexpressing CHIP, proteasome inhibition leads to a reduction in GR transactivation activity. Thus, the divergent response of a single transactivator (i.e. GR) to the UPP can be dictated by CHIP, an E3 ligase that also functions as a proteasome-targeting factor.
A Miniaturized Tunable Microstrip Antenna for Wireless Communications with Implanted Medical Devices (2007)

In this paper, a miniaturized microstrip antenna design is presented for establishing wireless communications with implantable medical devices in the 402--405 MHz Medical Implant Communications Services (MICS). The Ansoft's High Frequency Structure Simulator (HFSS) and CST Microwave Studio were used
Dendritic Cells Transduced to Express Interleukin-4 Prevent Diabetes in Nonobese Diabetic Mice with Advanced Insulitis (2003)

Our previous studies demonstrated that adoptive transfer of dendritic cells (DC) prevents diabetes in young nonobese diabetic (NOD) mice by inducing regulatory T(H)2 cells. In this report, as a means of treating NOD mice with more advanced insulitis, we infected DC with adenoviral vectors expressing interleukin (IL)-4 (Ad.IL-4), eGFP (Ad.eGFP), or empty vector (Ad psi 5). DC infected with any of the Ad vectors expressed higher levels of CD40, CD80, and CD86 molecules than uninfected DC and Ad.IL-4 DC produced IL-4 after lipopolysaccharide (LPS) and interferon (IFN)-gamma stimulation. Ad-infected DC efficiently stimulated allogeneic T cells, and cultures of T cells with Ad.IL-4 DC produced lower levels of IFN-gamma and marginally higher levels of IL-4. In vivo studies demonstrated that the Ad.eGFP DC trafficked to the pancreatic lymph nodes within 24 hr of intravenous administration, and could be visualized in the T cell areas of the spleen. The intrapancreatic IFN-gamma:IL-4 or IFN-gamma:IL-10 cytokine ratios were lower in 10-week-old mice treated with Ad.IL-4 DC, and these mice were significantly protected from disease. These results demonstrate, for the first time, that genetically modified DC can prevent diabetes in the context of advanced insulitis.
Raman spectroscopy of nanostructures and nanosized materials (2007)

Abstract The interest in micro and tip‐enhanced Raman spectroscopy in analyzing nanosized and nanostructured materials, chiefly semiconductors, oxides and pristine or functionalized carbon nanotubes, is reviewed in the light of contributions to this Special Issue. Particular attention is paid to the fact that chemical reactions, size or shape distribution, defects, strain and couplings may add to nanodimensionality in defining the Raman signature. Copyright © 2007 John Wiley & Sons, Ltd.
[Evidence-based evaluation of nutritional interventions: a comprehensive review and critical appraisal of current methods]. (2010)

探讨建立一个标准、严格的营养干预循证评价方法.通过检索电子数据库、查找参考文献和引文、咨询方法学专家,对现有循证评价方法进行全面综述;通过检索实证研究证据与方法学系统综述、识别广泛接受的方法学对现有循证评价方法进行严格评价,最终纳入12个合格的循证评价方法,识别并解决了9项方法学步骤上的差异,在综合分析的基础上提出了针对营养干预的循证评价方法学标准.本文建立的循证评价方法对营养干预具有良好的适用性。
Quasi-Optical Modelling of TelescopeSystems for Planck and STEAMR (2014)

This thesis is concerned with the high-frequency quasi-optical modelling of telescope systems, with special attention paid to the Planck satellite, but further work is also performed on the Stratosphere-Troposphere Exchange And climate Monitor Radiome- ter (STEAMR) and the Far Infrared Instrument (FIRI). The primary work surrounds the modelling of far sidelobe (FSL) patterns of the Planck telescope, with a view to replicating features seen in some of the difference maps made by the 857-GHz channel of Planck's High Frequency Instrument (HFI). This is done using a variety of techniques in a number of software packages. The General Reector Antenna Software Package (GRASP9) is used for accurate characterisation of the FSLs using two analysis methods: Physical Optics (PO), and Geometrical Optics (GO) with the Geometrical Theory of Diffraction (GTD). This is then compared against two simplified paraxial lens models of the telescope, namely the Projected-Aperture (PA) technique and Gaussian Beam Mode Analysis (GBMA). PA is performed by Fresnel integration of fields from source to sky, while GBM requires decomposition of a field into a set of Gauss-Laguerre modes which are propagated from source to sky using a ray matrix formalism. The motivation for analysing the Planck FSL structure is to test the assumption that features in the difference map are a result of manufacturing imperfections in the detector horns. To test this hypothesis a number of altered horn geometries are modelled using the NUI Maynooth Experimental Physics departments in-house waveguide mode-matching soft- ware called SCATTER, and these are then used in the analysis of the telescope system. Further use of SCATTER is illustrated in work on ultra-Gaussian horns for STEAMR, and here it is tested against commercial waveguide modelling software Microwave Wizard (uWW). Further modelling is performed for the Cardiff test-bed of the Planck telescope simulator, which was used for qualification of the Planck HFI ight horns pre-launch. Here we test the hypothesis that manufacturing imperfections could be missed if the effects on beam pattern were imperceptible to measurement. This is done using GRASP9, as is the modelling of FIRI, a multi-beam spectral/spatial interferometer which will hopefully break current constraints on angular resolution obtainable at infra-red wavelengths. In general, this thesis aims to provide insight into the modelling of quasi-optical telescope systems, with particular emphasis on multi-moded systems, providing useful information for future data analysis by the Planck project team.
Stress Amplification and Arch Dimensions in Proppant Beds Deposited by Waterfracs (2010)

Summary Equations and a procedure have been developed to calculate the excess stress induced on a proppant dune that is deposited by a waterfrac with poor proppant-transport characteristics. This method also calculates the dimensions of an arch region that forms above the bed. Stresses on the proppant at the top of such a dune are much greater than usually considered because of the need to support a wide proppant bed and the arch, suggesting that crushing and embedment are likely. The arch region itself is an extremely-high-conductivity pathway that may provide overall benefit in terms of cleanup and production, but may also aid sand production.
The Past, Present And Future Of Ligament Regenerative Engineering (2016)

Regenerative engineering has been defined as the convergence of Advanced Materials Sciences, Stem Cell Sciences, Physics, Developmental Biology and Clinical Translation for the regeneration of complex tissues and organ systems. Anterior cruciate ligament (ACL) reconstruction necessitates the regeneration of bone, ligament and their interface to achieve superior clinical results. In the past, the ACL has been repaired with the use of autologous and allogeneic grafts, which have their respective drawbacks. Currently, investigations on the use of biodegradable matrices to achieve knee stability and permit tissue regeneration are making promising advancements. In the future, utilizing regenerative biology cues to induce an endogenous regenerative response may aid the enhancement of clinical ACL reconstruction outcomes.
Automatic Identifying Interaction Components in Collaborative Cyber-Physical Systems (2019)

Due to diverse set of heterogeneous computing devices communicating with one another and fusing with physical components in Cyber-Physical Systems, software engineers may use different tools and/or modeling languages to formally describe or verify the system properties. As a result, the integration of these diverse constituents poses key challenges such as task for identifying interactions of components to be synthesized for a function in the systems. Although existing studies such as ontology and integration semantic languages have been used for specifying interactions of components in a Cyber-Physical System, these are still not applicable to discover the component interactions in collaborative Cyber-Physical Systems. It is due to the fact that functionalities of Cyber-Physical Systems are generally realized through interactions among multiple systems in a collaborative environment. This paper proposes a model interaction language, CyPhyML+ which can identify component interactions of realized functions in collaborative Cyber-Physical Systems. We show the proposed approach validity and applicability via an Automatic Incident Detection System.
A broadband solar absorber with 12 nm thick ultrathin <i>a</i>-Si layer by using random metallic nanomeshes (2014)

We show in theory, simulations, and experiments that, by applying random metallic nanomeshes, a broad-band multilayered structure with a 12 nm thick a-Si film as the active layer can absorb 89% of the total solar energy in the visible range from 400 nm to 700 nm. Such broadness and high absorption can be attributed to the random scattering introduced by the aperiodic metallic nanomeshes and the plasmonic-metamaterial design. The broadband and smooth electromagnetic response, combined with a very high absorption, is desired for solar energy harvesting devices, making this structure a good candidate for high efficiency photovoltaics with ultra-thin active layers.
Syntheses and quadratic hyperpolarizabilities of some (pyridylalkynyl)metal complexes: crystal structures of [Ni{2-(CC)C5H3NNO2-5}(PPh3)(η-C5H5)], [Au{2-(CC)C5H3NNO2-5}(PPh3)] and [Au{2-(CC)C5H4N}(PPh3)] ‡ (1997)

The complexes [Ru{2-(CC)C5H3NR-5}(PPh3)2(η-C5H5)] (R = NO2 1 or H 2), [Ni{2-(CC)C5H3NR-5}(PPh3)(η-C5H5)] (R = NO2 3 or H 4) and [Au{2-(CC)C5H3NR-5}L] (L = PPh3, R = NO2 5 or H 6; L = PMe3, R = NO2 7) have been synthesized and 3, 5 and 6 structurally characterized; no significant increase in quinoidal vinylidene contribution to the acetylide ground-state structure is apparent on progression from structurally characterized phenylacetylide complexes to the new pyridylacetylide complexes, or upon replacement of 5-H by 5-NO2 in progressing from 6 to 5. The molecular quadratic optical non-linearities of 1–7 have been determined by hyper-Rayleigh scattering (HRS). The HRS measurements at 1064 nm are consistent with an increase in β upon replacement of phenyl by an N-heterocyclic ring (replacing a nitrophenylacetylide by a nitropyridylacetylide ligand) for the ruthenium and gold systems, but with no change for the nickel complexes, and with an increase in non-linearity upon replacement of PMe3 by PPh3 in progressing from 7 to 5. The bulk second-order susceptibilities of the series have been determined by Kurtz powder measurements at 1064 nm, with the only significant response (about eight times that of urea) being that of 3; this complex was the only one of the three structurally characterized to pack non-centrosymmetrically in the crystal lattice. Electrochemical data for 1–4 have been obtained; comparison to analogous nitrophenylacetlylide complexes reveals that replacing nitrophenylacetylide by nitropyridylacetylide leads to a significant increase in MII/III oxidation potential for the ruthenium complexes, but to no change for the nickel examples. The parameter E°MII/III – E°NO2/NO2– was evaluated for 1–4, results for M = Ru vs. Ni being consistent with experimentally determined non-linearities, i.e. smaller ΔE° and larger non-linearities for ruthenium vs. nickel.
Sampling quantum phase space with squeezed states (1998)

We study the application of squeezed states in a quantum optical scheme for direct sampling of the phase space by photon counting. We prove that the detection setup with a squeezed coherent probe field is equivalent to the probing of the squeezed signal field with a coherent state. An example of the Schr odinger cat state measurement shows that the use of squeezed states allows one to detect clearly the interference between distinct phase space components despite losses through the unused output port of the setup.
Analog transmitter/trip unit system for engineered safeguard sensor trip inputs. Licensing topical report (1977)

This licensing topical report describes the Analog Transmitter/Trip Unit System for Engineered Safeguard Sensor Trip inputs. The system essentially replaces pressure, level and temperature switches with analog transmitter/trip unit combinations, which provide continual monitoring of critical parameters in addition to performing basic logic trip operations. The principal objective of the system is to improve sensor intelligence and reliability while greatly enhancing testing procedures. Design criteria and justification of application are included, as well as performance and essential qualification data for all new hardware. System implementation is designed to be suitable for all BWR power plants and is individually treated for operating plants, plants in late design phase, and plants in early design phase.
Effect of pressure on conductance. IV. Ionic association and Walden products in ethanol (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of pressure on conductance. IV. Ionic association and Walden products in ethanolEdward L. Cussler Jr. and Raymond M. FuossCite this: J. Phys. Chem. 1967, 71, 13, 4459–4464Publication Date (Print):December 1, 1967Publication History Published online1 May 2002Published inissue 1 December 1967https://pubs.acs.org/doi/10.1021/j100872a046https://doi.org/10.1021/j100872a046research-articleACS PublicationsRequest reuse permissionsArticle Views45Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Grasping Point Prediction in Cluttered Environment using Automatically Labeled Data (2020)

We propose a method to automatically generate high quality ground truth annotations for grasping point prediction and show the usefulness of these annotations by training a deep neural network to predict grasping candidates for objects in a cluttered environment. First, we acquire sequences of RGBD images of a real world picking scenario and leverage the sequential depth information to extract labels for grasping point prediction. Afterwards, we train a deep neural network to predict grasping points, establishing a fully automatic pipeline from acquiring data to a trained network without the need of human annotators. We show in our experiments that our network trained with automatically generated labels delivers high quality results for predicting grasping candidates, on par with a trained network which uses human annotated data. This work lowers the cost/complexity of creating specific datasets for grasping and makes it easy to expand the existing dataset without additional effort.
Modification of demineralized bone matrix by a chemical route (2004)

Demineralized bone matrix (DBM) is a well known osteoinductive biomaterial being used in bone related therapies and recently in biomolecular delivery. To widen its usage in therapeutic delivery, the present study was focused on chemical modification of DBM by a grafting technique using glycidylmethacrylate (GMA) as a monomer and ceric ammonium nitrate (CAN) as an initiating system. The chemical modification of DBM was proved by using Fourier transform infrared (FTIR) spectroscopy to analyze functional groups before and after grafting. The grafting results and grafting mechanism are described in detail. The chemically modified DBM was evaluated for in-vitro therapeutic delivery by coupling the gentamicin through epoxy functional groups introduced by GMA. The loading and release of gentamicin was evaluated in Hank's medium at pH 7.4 and 37 °C under physiological conditions and it was found to release the drug for a prolonged period as compared to ungrafted DBM. Based on the experimental results, the chemical modification paves the way to utilization of DBM macromolecules in therapeutic delivery.
Notes- Unsaturated Lactams. II. The Catalyctic Dehydrogenation of α,β-Unsaturated Valerolactams to Pyridones. (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes- Unsaturated Lactams. II. The Catalyctic Dehydrogenation of α,β-Unsaturated Valerolactams to Pyridones.Maurice Shamma and Paul RosenstockCite this: J. Org. Chem. 1961, 26, 7, 2586–2587Publication Date (Print):July 1, 1961Publication History Published online4 March 2003Published inissue 1 July 1961https://pubs.acs.org/doi/10.1021/jo01351a636https://doi.org/10.1021/jo01351a636research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Visual impairment in children with epilepsy treated with vigabatrin (2000)

Vigabatrin is an anti-epileptic drug particularly useful for drug-resistant partial seizures and infantile spasms. Recently, vigabatrin-induced visual field constriction (VFC) and abnormal ocular electrophysiological studies were reported. In this study, we assessed visual fields, visual evoked potentials (VEPs), and electroretinography (ERG) in children treated with vigabatrin. Twenty-four visually asymptomatic children underwent a clinical ophthalmological examination, perimetry when appropriate, and VEP and ERG. Thirteen patients had at least one abnormal study. VFC was seen in 11 of 17 patients who had perimetry; 5 of 15 patients who underwent VEP testing and 4 of 11 who underwent ERG testing had abnormal examinations. For the most part, abnormal VEPs and ERGs were found in children who also had VFC. There was a consistent trend for longer treatment periods to correlate with VFC, abnormal ERGs, and VEPs. In summary, over half of the children treated with vigabatrin demonstrated VFC or abnormal ocular electrophysiological studies. Perimetry seemed to be the most sensitive modality for identifying vigabatrin toxicity. Abnormal ERGs and VEPs were primarily seen in children with VFC and may be useful in monitoring children who are not appropriate candidates for perimetry. Although the incidence of vigabatrin-induced VFC is worrisome, in the context of intractable seizures or infantile spasms, therapeutic benefits must be weighed against risks.
Role of Nitric Oxide in the Chemistry and Anticancer Activity of Etoposide (VP-16,213) (2013)

Originally identified as an innate cytotoxin, nitric oxide ((·)NO) formation in tumors can influence chemotherapy and exacerbate cancer progression. Here, we examined the hypothesis that (·)NO generation contributes to cancer cell drug resistance toward the widely used anticancer drug Etoposide (VP-16). The UV-vis spectrum of VP-16 was not changed by exposure of VP-16 to (·)NO in aqueous buffer. In contrast, reddish-orange compound(s) characteristic of o-quinone- and nitroso-VP-16 were readily generated in a hydrophobic medium (chloroform) in an oxygen-dependent manner. Similar products were also formed when the VP-16 radical, generated from VP-16 and horseradish peroxidase/H2O2, was exposed directly to (·)NO in chloroform in the presence of oxygen. Separation and spectral analysis of VP-16 reaction extracts by electron spin resonance and UV-vis indicated the generation of the phenoxy radical and the o-quinone of VP-16, as well as putative nitroxide, iminoxyl, and other nitrogen oxide intermediates. Nitric oxide products of VP-16 displayed significantly diminished topoisomerase II-dependent cleavage of DNA and cytotoxicity to human HL-60 leukemia cells. LPS-mediated induction of nitric oxide synthase in murine macrophages resulted in VP-16 resistance compared to Raw cells. Furthermore, (·)NO products derived from iNOS rapidly reacted with VP-16 leading to decreased DNA damage and cytotoxicity. Together, these observations suggest that the formation of (·)NO in tumors (associated macrophages) can contribute to VP-16 resistance via the detoxification of VP-16.
Small-molecule inducers of insulin expression in pancreatic α-cells (2010)

High-content screening for small-molecule inducers of insulin expression identified the compound BRD7389, which caused alpha-cells to adopt several morphological and gene expression features of a beta-cell state. Assay-performance profile analysis suggests kinase inhibition as a mechanism of action, and we show that biochemical and cellular inhibition of the RSK kinase family by BRD7389 is likely related to its ability induce a beta-cell-like state. BRD7389 also increases the endocrine cell content and function of donor human pancreatic islets in culture.