gebhart/patrepeval huggingface dataset:
The Position of a Key Tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) Alters the Substrate Profile for This RmlC-like Enzyme (2004)

Vancomycin, the last line of defense antibiotic, depends upon the attachment of the carbohydrate vancosamine to an aglycone skeleton for antibacterial activity. Vancomycin is a naturally occurring secondary metabolite that can be produced by bacterial fermentation. To combat emerging resistance, it has been proposed to genetically engineer bacteria to produce analogues of vancomycin. This requires a detailed understanding of the biochemical steps in the synthesis of vancomycin. Here we report the 1.4 A structure and biochemical characterization of EvaD, an RmlC-like protein that is required for the C-5' epimerization during synthesis of dTDP-epivancosamine. EvaD, although clearly belonging to the RmlC class of enzymes, displays very low activity in the archetypal RmlC reaction (double epimerization of dTDP-6-deoxy-4-keto-D-glucose at C-3' and C-5'). The high resolution structure of EvaD compared with the structures of authentic RmlC enzymes indicates that a subtle change in the enzyme active site repositions a key catalytic Tyr residue. A mutant designed to re-establish the normal position of the Tyr increases the RmlC-like activity of EvaD.
Verbundwerkstoffe mit Aluminiumschaum – Anwendungen im Schienenfahrzeugbau (2007)

Abstract Nach ihrer Wiederentdeckung Anfang der 90er Jahre werden geschäumte Metalle inzwischen im industriellen Maßstab hergestellt. In den meisten Fällen handelt es sich dabei um Anwendungen, bei denen der Metallschaum im Verbund mit anderen Werkstoffen eingesetzt wird. Die Verbundkörper können in ebene oder komplex geformte Sandwichstrukturen und 3‐dimensionale Formkörper eingeteilt werden. Die erforderlichen Prozessschritte und realisierbaren Geometrien werden beschrieben. Die Eigenschaften der Werkstoffe werden beleuchtet und die industriellen Anwendungen anhand von Beispielen erläutert. Im Rahmen eines öffentlich geförderten Projekts wurde die Verwendung von Sandwichverbunden mit einer Kernlage aus Aluminiumschaum für Anwendungen im Schienenfahrzeugbau evaluiert. Insbesondere stand die Herstellung eines Frontmodulsegments im Mittelpunkt der Untersuchungen. Die Ergebnisse dieses Projekts werden vorgestellt.
A DRA modeling approach for correlating gaseous emissions of turbo-propulsion engine combustors (2001)

Gas turbine combustor aero-thermal design process relies strongly on the use of design database and multidimensional computational combustion dynamicsbased tools. Empirical correlations are currently used to capture the design database and scale combustors. We introduce a simple reactor-based technique primarily for data reduction and analysis (DRA) of the gaseous emissions from turbo-propulsion combustors. The DRA correlation methodology developed for the CFM56-2/3, CFM56-5/7, CF6-80C2 PreLEC and LEG, and GE90 DAC2 gives good agreement with emissions data along their sea-level engine operating lines with accuracy comparable with that of measurement.
The construction of analytic diffeomorphisms for exact robot navigation on star worlds (1991)

A <italic>Euclidean Sphere World</italic> is a compact connected submanifold of Euclidean <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="n"> <mml:semantics> <mml:mi>n</mml:mi> <mml:annotation encoding="application/x-tex">n</mml:annotation> </mml:semantics> </mml:math> </inline-formula>-space whose boundary is the disjoint union of a finite number of <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="left-parenthesis n minus 1 right-parenthesis"> <mml:semantics> <mml:mrow> <mml:mo stretchy="false">(</mml:mo> <mml:mi>n</mml:mi> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> <mml:mo stretchy="false">)</mml:mo> </mml:mrow> <mml:annotation encoding="application/x-tex">(n - 1)</mml:annotation> </mml:semantics> </mml:math> </inline-formula> dimensional Euclidean spheres. A <italic>Star World</italic> is a homeomorph of a Euclidean Sphere World, each of whose boundary components forms the boundary of a star shaped set. We construct a family of analytic diffeomorphisms from any analytic Star World to an appropriate Euclidean Sphere World "model." Since our construction is expressed in closed form using elementary algebraic operations, the family is effectively computable. The need for such a family of diffeomorphisms arises in the setting of robot navigation and control. We conclude by mentioning a topological classification problem whose resolution is critical to the eventual practicability of these results.
Preparation and characterization of diorgano- and dihalogeno-bis(monothio-β-diketonato)tin(<scp>IV</scp>) complexes. Crystal and molecular structures of SnY<sub>2</sub>(btbm)<sub>2</sub>and SnY<sub>2</sub>(tacac)<sub>2</sub>(Y = Me or Cl) (1988)

Diorgano- and dihalogeno-bis(monothio-β-diketonato)tin(IV) complexes have been prepared and their structures partially deduced by i.r. and n.m.r. data. In order to ascertain structural conclusions, X-ray crystal structure analyses were performed on the complexes SnMe2(btbm)2[Hbtbm = benzoyl(thiobenzoyl)methane] and SnMe2(tacac)2(Htacac = monothioacetylacetone), as well as their dichlorotin(IV) analogues, SnCl2(btbm)2 and SnCl2(tacac)2. The tin atoms in SnMe2(btbm)2 and SnMe2(tacac)2 show a strongly distorted octahedral environment with pairs of the same donor atoms (O, S) in the cis position. The two methyl groups deviate strongly from the trans position, C–Sn–C bond angles being 134.2 and 139.4° respectively. Comparatively long Sn–O bond distances reveal the anisobidentate nature of the ligand. In contrast, the dichloro complexes SnCl2(btbm)2 and SnCl2(tacac)2 exhibit octahedral geometries, the Cl–Sn–Cl bond angles being only 95.3 and 98.5° respectively, with the chlorine atoms in cis positions and the sulphur atoms in trans positions. The oxygen atoms show normal Sn–O bond lengths.
Current and next-generation passive optical networks (2008)

We describe network architectures and physical layer technologies associated with current and next-generation passive optical networks.
Flow Induced Rotation of a Flat Plate Subjected in Uniform Current Based on the Streamline Theory (2011)

This work describes the behavior of a vertical flat plate free to rotate in uniform current. The intention of this research is to study the fluttering problem that may occur with falling objects in water such as a manifold during the pendulous installation method (PIM). The free streamline theory is applied here to investigate the steady, two-dimensional flow at a given angle of attack past a flat plate with a fully developed wake. The leading and trailing edges of the plate are assumed to be sharp and the flow configurations are such that the free streamlines separate from the plate at these sharp edges, the thickness of the flat plate is assumed to be of zero. The Roshko’s model will be used to approximate the wake far downstream. The moment coefficient formulation has been calculated for different angles of attack yielding good accuracy with experimental results. This includes the existence of a natural frequency for small amplitude oscillations. The free-streamline theory confirms that the natural frequency is linearly proportional to the incoming flow velocity.
Aanlysis of Government's Role in Regional Coordinated Development (2007)

Unbalanced development often takes place in various economies,particularly in those nations where economic transformations are undergoing.China has undergone unbalanced development,but has a growing trend in recent years.As an important part of 11th Five-year plan the coordinated regional development has been put on the contents.This paper reveals the lack of co-ordination of the regional status quo,and from the point of view of the profound causes of this phenomenon.In referring to foreign experience and based on the basis of the actual conditions of our country,the government must adhere to the four coordinated regional development goals dealing with three pairs,to implement five measures.
Purified Somatotrophs from Rat Adenohypophysis: Response to Secretagogues<sup>1</sup> (1974)

We previously reported methods for the preparation of enriched and purified dispersed somatotrophs from the rat adenohypophysis. We now demonstrate that the somatotrophs retain (a) their GH content during the purification proceduresand (b) their responsiveness to dibutyryl cyclic AMP and to a partially purified hypothalamic extract, rich in GHRF (GH-releasing factor) activity. This dispersed somatotroph preparation may provide a novel and useful tool in the study of the mechanisms governing the synthesis and release of GH. (Endocrinology94: 1525, 1974)
Erratum to: Improved measurements of the neutrino mixing angle θ 13 with the Double Chooz detector (2015)

Made available in DSpace on 2016-06-07T13:13:34Z (GMT). No. of bitstreams: 2 wos_000350334400001.pdf: 2460632 bytes, checksum: 6dd44c7594aedf5cb4cd37d3c250eb9c (MD5) wos_000350334400001errata.pdf: 379806 bytes, checksum: b71c8603fbc09339d1d45e05b9494a9d (MD5) Previous issue date: 2015
Enthalpies of solution and formation of some uranium oxides (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnthalpies of solution and formation of some uranium oxidesGeorge C. Fitzgibbon, Daniel Pavone, and Charles E. Holley Jr.Cite this: J. Chem. Eng. Data 1967, 12, 1, 122–125Publication Date (Print):January 1, 1967Publication History Published online1 May 2002Published inissue 1 January 1967https://pubs.acs.org/doi/10.1021/je60032a039https://doi.org/10.1021/je60032a039research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Kynurenine Pathway Metabolites in Cerebrospinal Fluid and Serum in Complex Partial Seizures (1994)

The kynurenine pathway metabolites, quinolinic acid (QUIN) and L-kynurenine are convulsants, whereas kynurenic acid (KYNA) is an antagonist of excitatory amino acid receptors. Imbalances in the concentrations of these metabolites have been implicated in the etiology of human seizure disorders. In the present study, L-kynurenine and QUIN concentrations in both cerebrospinal fluid (CSF) and serum were reduced in patients with intractable complex partial seizures (CPS) in both the postictal period (15-75 min after a seizure) and the interictal period (absence of seizure for > 24 h) as compared with neurologically normal control subjects. Linear regression analyses and analysis of covariance showed that the reductions in serum QUIN and L-kynurenine were correlated to blood antiepileptic medication. L-Tryptophan (L-TRP) levels also tended to be lower in both CSF and serum of the seizure patients. CSF KYNA and serum 3-hydroxykynurenine concentrations were not affected in seizure patients, whereas serum levels of KYNA were reduced. 3-Hydroxykynurenine was not detected in the CSF of either control or seizure patients. The results do not support a role for a generalized reduction in KYNA concentrations or an increased ratio of QUIN:KYNA, or increases in CSF L-kynurenine in initiation and maintenance of intractable CPS humans.
Measurement of Individual Preferences (1982)

Women in two Ontario cities were asked to express their preferences about a medical decision: A fictitious patient with cancer was to be treated either conservatively without hope of cure, or radically, by a risky treatment having cure or immediate death as possible outcomes. Situation-specific variables were varied systematically across the sample by varying the levels of the fictitious patient's physical and psychosocial health and achievement motivation. The results obtained indicate that individual preferences shift in response to changes in the situation in which the decision is made. These findings raise questions about the uses to be made of measurements of preferences, especially in relation to what is meant by a "best decision."
Shock wave and plasma dynamics in a surface discharge flash lamp (1994)

Shock waves and plasma dynamics induced by an open discharge called a ‘‘formed-ferrite-plasma’’ source result in intense radiation from the visible to the vacuum ultraviolet region. An experimental study of both the shock waves and plasma expansions from the ferrite surface has been carried out as a function of electrical energy deposition and of background argon pressure. We show that the propagation of the shock wave is accurately described by the following expression: R=b(E/ρ0)αtn, where R is the distance of the shock front from the surface of the ferrite; E the deposited energy; ρ0 the density of background gas; b, α, and n three constants, and t the time.
S27 Interobserver Agreement of Modified Paris Classification and Histology Prediction of Colorectal Lesions in Patients With Inflammatory Bowel Disease (2022)

Background: It is recommended by the current SCENIC guidelines (International Consensus Statement on Surveillance and Management of Dysplasia in IBD) that visible dysplasia in patients with longstanding IBD should be endoscopically characterized using a modified Paris classification. The validity of this classification has not been determined. This study aims to measure the interobserver agreement of the Paris and modified Paris classification for IBD visible dysplasia. Secondary endpoints include the endoscopists’ accuracy for pathology prediction and border assessment for each lesion. Methods: A total of 100 de-identified endoscopic still images and 30 videos of IBD visible colorectal lesions were graded by 10 senior and 4 trainee endoscopists from 5 tertiary care centers. The endoscopists were asked to assign 4 classifications for each image: 1. Standard Paris, 2. Modified Paris, 3. Pathology prediction (dysplastic, non-dysplastic or serrated) and 4. Lesion Border: distinct or indistinct. Agreement was measured using Light’s Kappa coefficient. Consensus of ratings was assessed according to strict majority. If no majority was achieved, consensus was recorded as “none.” Results: The overall Light’s Kappa for all study endpoints was between 0.32 and 0.49. In subgroup analysis between junior and senior endoscopists, Light’s Kappa continued to be less than 0.6 with a slightly higher agreement amongst juniors. Lesions with lowest agreement and no consensus were mostly classified as Is, IIa and mixed for Paris and sessile and superficial elevated for modified Paris classifications. Endoscopists’ accuracy for prediction of dysplastic, non-dysplastic and serrated pathology was 77%, 56% and 30% respectively. There was a strong association (P < 0.001) between the given morphology classification and the predicted pathology with Ip lesions carrying a much lower expectation of dysplasia than Is/IIc/III and mixed lesions. The agreement for border prediction was 0.5 for junior and 0.3 for senior endoscopists. Conclusion(s): This study demonstrates very low IOA for Paris and Modified Paris classifications and low accuracy and IOA for lesion histopathology prediction. Revisions of these classifications are required to create a clinically useful risk stratification tool and enable eventual application of augmented intelligence tools.
A calorimetric comparison of trypsin and its anhydro modification in complex formation with Kunitz soybean inhibitor. (1980)

The heat of complex formation between native trypsin or its anhydro modification (Ako, H., Foster, R. J., and Ryan, C. J. (1972) Biochem. Biophys. Res Commun. 47, 1402--1407) with native or cleaved Kunitz soybean inhibitor (Finkenstadt, W. R., and Laskowski, M., Jr. (1965) J. Biol. Chem. 240, 962--963) has been observed from pH 3.5 to 7.5. Steep dependence of reaction heat upon pH between pH 3.5 and 4.25 is observed with native inhibitor in reaction with both trypsin and anhydrotrypsin. The character of this heat-pH relationship is consistent with a cooperative process involving three to four ionizable groups. Above pH 4.25, trypsin and anhydrotrypsin in reaction with native inhibitor have quite different pH dependencies. Native trypsin shows an apparent pK near pH 5, whereas anhydrotrypsin + inhibitor reaction heat remains nearly constant from pH 4.5 to 6, and shows an apparent pK near pH 7.0. Above pH 4, the reaction heat-pH relations for native or cleaved inhibitor in reaction with trypsin are only slightly different (Barnhill, M. T., Jr., and Trowbridge, C. G. (1975) J. Biol. Chem. 250, 5501--5507). On the other hand, substitution of cleaved for native inhibitor in reaction with anhydrotrypsin causes a greatly reduced reaction heat, with no clearly developed pH dependence from pH 5.5 to 7.5. The reaction heat-pH relationships are analyzed thermodynamically in terms of the temperature coefficient of a pH-dependent equilibrium constant. It is clear that conversion of the active site serine side chain of trypsin to dehydroalanine changes the pH dependence of its reaction heat with soybean inhibitor, and that the complex formed is sensitive to the state of the scissile inhibitor bond. These differences provide a comparison of a protein-protein association with and without covalent bond formation between reactants.
ChemInform Abstract: KATALYSE DURCH METALLKOMPLEXE 10. MITT. ADDITION VON TRIMETHYLSILANOL AN BUTADIEN (1973)

Abstract Neue katalytische Systeme, Pd(0)‐ und Pd(II)‐Komplexe sowie auf Copolymere aufgezogene Pd(0)‐ und Pd(II)‐Komplexe, für die Darstellung von l‐Trimethylsiloxy‐octadien‐(2,7) durch die Titel.reaktion werden untersucht.
The Phase Transition of Cholesteryl Esters and Variation of Dielectric Properties (1972)

The phase transition temperatures in the solid, liquid crystal, and isotropic liquid states of four cholesteryl esters have been determined in the heating and cooling cycles by a polarization microscope at the crossed nicoles, and by the differential thermal analysis and the measurement of the dielectric constant and dielectric loss. Values of ε' and ε'' were found not to be the same in heating and cooling. Data of transition temperatures obtained from these various methods are generally in good agreement with each other, and are found to be useful for mesophase identification. The difference in dielectric properties has not been observed between the smectic phase and the cholesteric phase.
Photography as new media: From the camera obscura to the camera phone (2006)

<p>William J Mitchell stated that on its 150th anniversary in 1989 photography was dead, at least as it had been known, and that the digital era signaled a new paradigm shift for photography at large. In an unprecedented way 16 years later, the web and camera phones are redefining photographyonce more, signaling another paradigm shift. The photographic image is no longer a printed image, it is much more likely to be seen on a screen than on paper. Images can be easily shared and disseminated via the web, which has superseded the traditional modes of presentation and publication.Photography has never been so instantaneous or so disposable, one click to capture and another to delete. Photography (still & moving) has simultaneously shaped and recorded history, what then will be the impact of the disposability of the image in the digital age and the ephemeral nature of â€˜born-digitalâ€™ materials and the web at large remains to be seen. With the exponential technological change that has occurred over the last decade, photographyâ€™s artistic and social utilisation requires that the medium and the concept be reconsidered, yet again. The web has created new opportunities for the dissemination and exhibition of photographic work and the camera phone is only just beginning to have an impact. We are beginning to see their artistic and social utilization increase and act as a nucleus for new forms of social and cultural practice and the beginning of a new era of artistic exploration.</p>
Preparation of a Polysulfone Composite for Alpha Radiation Detection (2010)

A polymer composite for alpha radiation detection was prepared by coating a ZnS(Ag) scintillator over a polysulfone (PSF) base layer. The base layer and active ZnS(Ag)layer were formed by the evaporation of a solvent from the solution films of a binary solution of PSF and methylene chloride (MC), and a ternary scintillator paste of PSF, ZnS(Ag), and dimethylformamide (DMF), respectively. Since the scintillator paste was screen-printed without any extra binder on the surface of a solidified base layer, PSF works as a transparent and mechanical support layer as well as a binder for ZnS(Ag) coating, while maintaining the monolithic feature of the composite. The prepared composite was pliable and flexible enough to be rolled up like paper. The alpha detection of the composite was efficient enough to determine the activity of alpha radiation.
Double-blind comparison of sertraline, imipramine, and placebo in the treatment of dysthymia: psychosocial outcomes (1997)

Pharmacotherapy is an effective treatment for dysthymia in terms of psychosocial functioning as well as depressive symptoms, even when the dysthymia is long-standing.
B-CONVINCED: Beta-blocker CONtinuation Vs. INterruption in patients with Congestive heart failure hospitalizED for a decompensation episode (2009)

In conclusion, during ADHF, continuation of beta-blocker therapy is not associated with delayed or lesser improvement, but with a higher rate of chronic prescription of beta-blocker therapy after 3 months, the benefit of which is well established.
LETTERS TO THE EDITOR (1986)

Fabian, Timothy C. M.D.; Mangiante, Eugene C. M.D.; Patterson, C Richard M.D.; Britt, Louis G. M.D. Author Information
Simulating ferroresonance in a series compensated distribution network (2002)

Electromagnetic transient simulation programs are commonly used in power quality studies of power system networks. This paper describes the analysis of a distribution network that has experienced catastrophic events of a ferroresonant nature. Following a brief overview of ferroresonance, an emphasis is placed on duplicating field measurements in the PSCAD/EMTDC environment. A discussion of possible mitigation routines and their simulated results ensues.
Control of the quantum path-target state distance: bistable-like characteristic in a small tight-binding system (1987)

The control of the distance between the quantum path and a given target state in the state space of an (N+2) tight-binding isolated system prepared in a non-stationary initial state is studied as a function of an asymmetry introduced by a change in only one of the coupling constants. When N>6, a bistable-like characteristic is found for the variation of the minimum distance between the path and the target as a function of this asymmetry. Optimised systems are proposed to reach the best control of this distance by the asymmetry.