gebhart/patrepeval huggingface dataset:
<i>Factors Predictive of Venous Thromboembolism in Bariatric Surgery</i> (2011)

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in bariatric surgery. The aim of this study was to evaluate the effect of patient characteristics, payer type, comorbidities, and surgical techniques on development of VTE in bariatric surgery. Using the National Inpatient Sample (NIS) database from 2006 to 2008, clinical data of 304,515 morbidly obese patients who underwent bariatric surgery were examined. Multiple regression analysis was performed to identify factors predictive of VTE. The overall rate of in-hospital VTE was 0.17 per cent, with the highest rate of VTE observed in open gastric bypass (0.45%). The VTE rate was significantly lower in laparoscopic compared with open gastric bypass (0.13% vs 0.45%, respectively, P < 0.01) and in nongastric bypass compared with gastric bypass procedures (0.06% vs 0.21%, respectively, P < 0.01). Alcohol abuse [odds ratio (OR): 8.7], open operation (OR: 2.5), gastric bypass procedures (OR: 2.4), renal failure (OR: 2.3), congestive heart failure (OR: 2.0), male gender (OR: 1.5), and chronic lung disease (OR: 1.4) were associated with a higher rate of VTE. This study identified several significant risk factors for development of VTE in bariatric surgery. To minimize the risk of VTE, surgeons may consider these factors in selection of appropriate prophylaxis and bariatric surgical options.
ChemInform Abstract: Enantioselective S‐Oxidation: Synthetic Applications (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Catalytic and physicochemical characterizations of novel oxide-supported copper catalysts. Part 1.—Hydrosol-prepared Cu/TiO<sub>2</sub>and effects of prereduction on hydrogenation and oligomerization of acetone (1993)

Catalytic conversions of acetone, allied to transmission electron microscopy (TEM), electron spectroscopy for chemical applications (ESCA) and temperature-programmed desorption (TPD) techniques have been used to characterize titanium-dioxide-supported copper preformed by the reduction of aqueous copper malonate with hydrazine. Scanning electron microscopy (SEM) and TEM showed aggregates of 30 ± 10 nm TiO2 particles edged by smaller copper particles (ca. 10 nm). The coexistence of copper and TiO2 in such aggregates was confirmed by energy dispersive X-ray analysis (EDXA). Comparisons of the X-ray photoelectron spectroscopy (XPS) Cu 2p3/2 and X-ray excited Auger electron spectroscopy (XAES) Cu L3M4,5M4,5 features of the ‘as-stored’ materials with those after in situ reduction at 453, 503 and 548 K, confirmed that Cu2+ was converted to Cu + after reduction at 503 K. Significant amounts of Cu+ were also present after reduction at 503 K, but little or no Cu0. At 423 K < Trx < 453 K over samples prereduced at 473 K, only acetone hydrogenation to isopropyl alcohol was detected, with single-pass conversion increasing with Trx until approximating to the equilibrium-limited conversion at 453 K. A strong metal/support interaction (SMSI) type inhibition of this selective hydrogenation capability was observed after high-temperature reduction at 773 K (HTR773). At 483K < Trx < 513K further catalytic activity of the lowtemperature reduction (LTR) materials emerged, namely that for aldol-condensation-type conversions of the acetone and H2 reactants to yield mainly C(6) and C(9) saturated ketones. This was not inhibited by prior HTR.
Persistent adhesion of epithelial tissue is sensitive to polymer topography (1999)

The persistent adhesion of corneal epithelial tissue to the surface of a porous polymer is of interest in the development of a corneal onlay. Using an in vitro model system, this study examined the effect of polymer surface topography on the assembly of basement membrane and hemidesmosomes. Corneal epithelial tissue was grown on polycarbonate surfaces with a range of pore sizes (0.1-3.0 micron, pore diameter) and an equivalent nonporous surface. The ultrastructure of the tissue-polymer interface was evaluated using electron microscopy. On the porous surfaces, the tissue responded to a balance between the size of the discontinuity (pores) and the amount of polymer surface between the pores. Continuous basement membrane and a regular pattern of hemidesmosomal plaque occurred only on the 0.1 micron surface, where both the pores and the total surface area covered by pores were relatively small. The assembly of adhesive structures on surfaces with pore diameters between 0.4-2.0 microns was restricted to regions of polymer between pores. No adhesive structures assembled on the nonporous or on the 3.0-micron surface. These results demonstrate that, in addition to porosity, surface topography is a significant factor in the formation of structures involved in the persistent adhesion of stratified epithelial tissue on a polymer.
An update review of stem cell applications in burns and wound care (2012)

The ultimate goal of the treatment of cutaneous burns and wounds is to restore the damaged skin both structurally and functionally to its original state. Recent research advances have shown the great potential of stem cells in improving the rate and quality of wound healing and regenerating the skin and its appendages. Stem cell-based therapeutic strategies offer new prospects in the medical technology for burns and wounds care. This review seeks to give an updated overview of the applications of stem cell therapy in burns and wound management since our previous review of the "stem cell strategies in burns care".
Pulsed microwave induced light, sound, and electrical discharge enhanced by a biopolymer (1999)

Intense flashes of light were observed in sodium bicarbonate and hydrogen peroxide solutions when they were exposed to pulsed microwave radiation, and the response was greatly enhanced by a microwave-absorbing, biosynthesized polymer, diazoluminomelanin. A FPS-7B radar transmitter, operating at 1.25 GHz provided pulses of 5.73 +/- 0.09 micros in duration at 10.00 +/- 0.03 pulses/s with 2.07 +/- 0.08 MW forward power (mean +/- standard deviation), induced the effect but only when the appropriate chemical interaction was present. This phenomenon involves acoustic wave generation, bubble formation, pulsed luminescence, ionized gas ejection, and electrical discharge. The use of pulsed microwave radiation to generate highly focused energy deposition opens up the possibility of a variety of biomedical applications, including targeting killing of microbes or eukaryotic cells. The full range of microwave intensities and frequencies that induce these effects has yet to be explored and, therefore, the health and safety implications of generating the phenomena in living tissues remain an open question.
Neurodevelopmental Outcome in Survivors of Periventricular Hemorrhagic Infarction (2007)

In the current era, two thirds of periventricular hemorrhagic infarction survivors develop significant cognitive and/or motor abnormalities, whereas adaptive skills are relatively spared. Higher cranial ultrasound-based periventricular hemorrhagic infarction severity scores predict worse outcome in several modalities and may prove to be a valuable tool for prognostication.
A SENSITIVE SPECIFIC ENZYMATIC‐FLUOROMETRIC ASSAY FOR HOMOCARNOSINE<sup>1</sup> (1973)

Abstract We have developed a sensitive and specific assay for homocarnosine in tissues. Homocarnosine is separated from GABA by ion exchange chromatography. After hydrolysis of homocarnosine with swine kidney carnosinase, the evolved GABA is measured by an enzymatic‐fluorometric procedure. As little as 0.1 nmol of tissue homocarnosine can be detected by this procedure. Homoanserine, which would be detected by this assay, can be separated from homocarnosine by thin layer chromatography. No homoanserine could be detected in any tissues examined. There are marked regional variations in levels of homocarnosine in guinea‐pig brain that do not correspond to regional differences in GABA levels.
Cytosolic Genomic DNA functions as a Natural Antisense (2018)

Stress conditions such as UV irradiation, exposure to genotoxic agents, stalled DNA replication, and even tumors trigger the release of cytosolic genomic DNA (cgDNA). Classically, cgDNA induces interferon response via its binding to proteins such as STING. In this study, we found previously reported cgDNA (cg721) exists in the cytosol of the mouse cell lines, cultured under no stress conditions. The overexpression of cg721 suppressed the complementary RNA expression using strand selection and knockdown of DNA/RNA hybrid R-loop removing enzyme RNase H and three prime repair exonuclease 1 TREX1 increased the expression levels of cg721 and thus, inhibited the target Naa40 transcript, as well as protein expression, with a phenotypic effect. In addition, cgDNA was incorporated into extracellular vesicles (EVs), and the EV-derived cg721 inhibited gene expression of the acceptor cells. Thus, our findings suggest that cg721 functions as a natural antisense DNA and play a role in cell-to-cell gene regulation once it secreted outside the cell as EVs.
Phenol Oxidation in Aqueous Solution by Gas Phase Corona Discharge (2006)

Abstract In this paper, results of phenol degradation in water induced by a DC corona discharge run in air-like gas mixture above the water surface are presented. The DC positive corona discharge was generated between a stressed hollow needle and the water surface. Air with 1.5% CO
COMPARISON OF SURICLONE AND LORAZEPAM IN THE TREATMENT OF GENERALIZED ANXIETY DISORDERS IN THE ELDERLY (1992)

*Groupe Hospitalier Bichat-Claude Bernard, 46, rue H. Huchard, 75018 Paris, France.**Centre Psychiatrique St. Bernard 43, rue J. Empain, B-7170 Manage, Belgium.***Spécia, 16, rue Clisson, 75013 Paris, France.**** CNS Dpt, Rhˆne-Poulenc Rorer, 20, avenue Raymond Aron, 92165 Antony cédex, France.
New thermochemical evidence on the stability of dickite vs. kaolinite (2003)

The energetics of the Saint Claire dickite sample, a highly pure and low defect material, have been studied by high-temperature oxide-melt solution calorimetry. Data were corrected for adsorbed water, the only significant impurity to the ideal formula Al2Si2O5(OH)4. Enthalpies of dickite dissolution into molten lead borate at 702 °C and of dickite formation from the oxides and from the elements at 25 °C and 1 bar are 356.3 ± 3.3 kJ/mol, -31.1 ± 4.2 kJ/mol, and -4099.8 ± 4.8 kJ/mol, respectively. Using entropy data from the literature, the standard Gibbs free energy of dickite formation from the elements at 25 °C is -3777.5 ± 4.8 kJ/mol. This value is 7 to 25 kJ/mol more endothermic than literature values obtained for other dickites by calculations, solubility measurements, or calorimetry. Since the Saint Claire dickite is almost pure, the applied corrections are very small and these results are likely to be the most reliable of the available data. The Gibbs free energy of formation of the Saint Claire dickite at 25 °C and 1 bar is 12 to 25 kJ/mol less negative than data obtained for kaolinite using the same and different techniques. This trend is unlikely to reverse at higher temperature and/or pressure in the range of kaolin mineral occurrences. Thus, the new data further corroborate our earlier findings that dickite is thermodynamically metastable relative to kaolinite. This is in agreement with results obtained by mineral synthesis and with most of the observations of kaolinite and dickite occurrences in natural environments. However, further investigations are required to fully explain the transformation of kaolinite to dickite, which appears to occur during diagenesis.
Behandlung fetthaltiger Abwässer der Lebensmittelindustrie mit einem thermophilen Mikroorganismus (2002)

No translation.
Terminal deoxynucleotidyl transferase-negative acute lymphoblastic leukemia. (2000)

All ALL cases (L1 and L2) were TdT-positive, except for 3 cases that were of early T-cell lineage. None of the 3 cases demonstrated positivity for TdT in immunofluorescence staining with polyclonal antibodies or flow cytometry with monoclonal antibodies. Flow cytometric analysis confirmed a pre-T-cell immunophenotype in all 3 cases. One of the cases showed rearrangement of a T-cell antigen receptor and immunoglobulin heavy chain (J(H)). A second case showed germline configuration of T-cell receptors, but also showed rearrangement of the J(H), despite the expression of T-cell markers only.
Metal−Molecule Schottky Junction Effects in Surface Enhanced Raman Scattering (2010)

We propose a complementary interpretation of the mechanism responsible for the strong enhancement observed in surface enhanced raman scattering (SERS). The effect of a strong static local electric field due to the Schottky barrier at the metal-molecule junction on SERS is systematically investigated. The study provides a viable explanation to the low repeatability of SERS experiments as well as the Raman peak shifts as observed in SERS and raw Raman spectra. It was found that a strong electrostatic built-in field at the metal-molecule junction along specific orientations can result in 2-4 more orders of enhancement in SERS.
Enhanced Water Splitting at Thin Film Tungsten Trioxide Photoanodes Bearing Plasmonic Gold–Polyoxometalate Particles (2014)

Tungsten trioxide (WO3) is one of a few stable semiconductor materials liable to produce solar fuel by photoelectrochemical water splitting. To enhance its visible light conversion efficiency, we incorporated plasmonic gold nanoparticles (Au NPs) derivatized with polyoxometalate (H3PMo12O40) species into WO3. The combined plasmonic and catalytic effect of Au NPs anchored to the WO3 surface resulted in a large increase of water photooxidation currents. Shielding the Au NPs with polyoxometalates appears to be an effective means to avoid formation of recombination centers at the photoanode surface.
Isolation of a new toxin, prosurugatoxin, from the toxic Japanese ivory shell, Babylonia japonica. (1985)

A new toxin, named prosurugatoxin because it formed surugatoxin on decomposition, was isolated from the toxicated Japanese ivory shell (Babylonia japonica). Prosurugatoxin evoked mydriasis in mice at a minimum effective intraperitoneal dose of 15 ng/g body weight, and inhibited the contractile response of isolated guinea pig ileum induced by 3×10-5g/ml of nicotine at a concentration of 5×10-9g/ml. In this mollusc the prosurugatoxin content was about 5 times that of neosurugatoxin. Prosurugatoxin was deduced on the basis of physical and chemical data to be des-xylopyranosyl-neosurugatoxin.
Temporal Clustering of Hemorrhages from Untreated Cavernous Malformations of the Central Nervous System (2001)

OBJECTIVE Hemorrhages from cerebral cavernous malformations (CMs) sometimes seem to occur in closely spaced “clusters” interspersed with long hemorrhage-free intervals. Clustering of hemorrhages could affect retrospective assessments of radiosurgery efficacy in prevention of CM rehemorrhage. However, this empirical observation had not been tested quantitatively. To test whether CM hemorrhages tend to cluster, we reviewed pretreatment rebleeding rates after a first symptomatic hemorrhage in CM patients who later underwent surgery or radiosurgery. METHODS We performed a retrospective review of 141 patients with CMs who presented with clinically overt hemorrhage, and who subsequently underwent surgery or proton beam radiosurgery during an 18-year period. Statistical models were used to analyze all events per person and identify potential variation in rebleeding risk with time after a previous hemorrhage. RESULTS Sixty-three of 141 patients experienced a second hemorrhage before treatment; 16 had additional hemorrhages. Five hundred thirty-eight patient years elapsed between first hemorrhages and treatment. The cumulative incidence of a second hemorrhage after the first CM hemorrhage was 14% after 1 year and 56% after 5 years. During the first 2.5 years after a hemorrhage, the monthly rehemorrhage hazard was 2%. The risk then decreased spontaneously to less than 1% per month, which represents a 2.4-fold decline (P < 0.001). Rehemorrhage rates were higher in younger patients (P < 0.01), but not in females or in patients with deep lesions. Shorter intervals between successive hemorrhages did not predict higher subsequent rehemorrhage risk. CONCLUSION The rehemorrhage rate from untreated CMs is high initially, and it decreases 2 to 3 years after a previous hemorrhage. This hazard pattern generates the observed temporal clustering of hemorrhages from untreated CMs.
Immune regulatory effects of FTY720 on human T cells (P1.143) (2015)

Objective: We investigated immune regulatory effects of FTY720 on T cells in Multiple Sclerosis (MS) and controls. Background: FTY720 (Gilenya) is the functional analogue of Sphingosine and is the first oral treatment for relapsing remitting MS. FTY720 regulates immune cell trafficking and prevents relapses in Multiple Sclerosis. Method: T cells percentages in treated MS patients were measured using Fluorescence activated cell staining. T cell proliferation and the cytokines produced by activated T cells were measured using luminex assays. Gene expression profiles in activated T cells were measured using nanostring arrays and qPCR. Results: We found that the percentages of naïve T cells and central memory T cells are decreased, whereas regulatory T cells are increased, in peripheral blood from MS patients upon FTY720 treatment. T cells activated in the presence of FTY-720 were less inflammatory with decreased proliferation and cytokines expression. Human neurons are susceptible to granzyme B produced from T cells present in MS active lesions. We found that FTY720 treated cells have decreased expression of granzyme B and induced less neuronal cytotoxicity. We showed, FTY720 treated T cells have unique anti-inflammatory immune gene profile. The anti-inflammatory effect of FTY720 on T cells is dependent upon the increased expression of regulatory transcription factor TCF1 (Transcription factor 1). TCF1 has been previously linked to T- cell differentiation and lineage specification. We show that the TCF1 has direct binding on the promoter of MS effector genes such as IFN-γ and IL17. Knock down of TCF1 using lentivirus increased the cytokine expression and converted an anti-inflammatory T cells phenotype to pro-inflammatory T cell. Ex-vivo isolated T cells from treated MS patients showed similar less inflammatory phenotype upon FTY720 treatment. Conclusion: FTY720 has immune regulatory effects on human T cells and these effects are dependent upon the expression of regulatory transcription factor TCF1.
ChemInform Abstract: Efficient Synthesis of Enantiomerically Pure trans‐2,5‐Bis(arylethynyl)pyrrolidines. A New Entry into C<sub>2</sub>‐Symmetric Chiral Secondary Amines. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High temperature aging of enameled copper wire &#x2014; Relationships between chemical structure and electrical behavior (2011)

This work presents the physico-chemical behavior of several enameled copper wires systems such as PolyEsterImide (PEI)/PolyAmideImide (PAI) or PAI based multi layers compared to PolyImide (PI) which remains the basic enamel material for high temperature applications. The structural, thermal and electrical properties of these systems have been investigated before and after aging in the 200°C–400°C temperature range by thermogravimetric analysis (TGA), ATR-FTIR microscopy, thermomechanical analysis (TMA) and dielectric relaxation spectroscopy (DRS). It has been particularly interesting to carry out physico-chemical analysis directly on enameled wires to improve the understanding of their thermal and electrical behaviour. Dielectric spectroscopy has indicated a loss of insulating properties during the thermal cycle especially for PEI-containing enamels whereas the properties of PI and PAI have been maintained. TGA and IR analyses have not only allowed confirming the PI and PAI high thermal performances, but have also given information on the thermal and chemical stability of PEI/PAI. Such investigations could be helpful for improving the enameled wire high temperature performances.
Hybrid Optimal-Based Control of a Boost Converter (2009)

Recently, a new approach to control switching in a boost converter was developed based upon hybrid optimal control theory. A focus of the initial research was on the theoretical development of the control and using simulation to compare its performance to more traditional control approaches. Herein, the research is extended with a particular focus on the hardware implementation of the approach. Included in the implementation are techniques to compensate for delay resulting from computation and sampling. In addition, a new parameter estimator has been derived to estimate load resistance and source voltage required by the controller. The results of time-domain simulation and hardware experiments are used to validate the performance of the hybrid optimal control and estimator.
A CHI wiggler ubitron amplifier experiment: wiggler characterization (2002)

A Ka-band (26-40 GHz) coaxial hybrid iron (CHI) wiggler ubitron amplifier experiment under construction at the Naval Research Laboratory is described. The principal goal of the experiment is to investigate the performance tradeoffs involved in the CHI configuration for high frequency amplifiers operating at low voltages with small wiggler periods. The nominal design parameters are a center frequency of 35 GHz, wiggler period of 0.75 cm, and beam voltage of approximately 150 kV. Nonlinear simulations of the interaction are presented, along with the results of magnetic field measurements performed on a prototype version of the CHI wiggler.
Synthesis of rigid, heterocyclic dipeptide analogs (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of rigid, heterocyclic dipeptide analogsDale J. Kempf and Stephen L. CondonCite this: J. Org. Chem. 1990, 55, 4, 1390–1394Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://doi.org/10.1021/jo00291a060Request reuse permissionsArticle Views766Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (735 KB) Get e-Alertsclose Get e-Alerts