gebhart/patrepeval huggingface dataset:
Review: The Role of Membrane Peptidase in Immune Functions (2006)

Uwe Lendeckel, Thilo Kahne, Dagmar Riemann, Klaus Neubert, Marco Arndt and Dirk Reinhold Institute of Experimental Internal Medicine, Center of Internal Medicine, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, D-39120 Magdeburg, Germany Institute of Medical Immunology,Martin-Luther-University Halle-Wittenberg, Strasse der Opfer des Faschismus 6, D-06097 Halle, Germany Institute of Biochemistry, Dept. Biochemistry & Biotechnology, Martin-Luther-University Halle-Wittenberg, Kurt-Mothes-Strasse 3, D-06120 Halle, Germany
The Electronic Spectra of Aniline and <i>N</i>-Methylaniline Adsorbed on Aluminum Chloride. I (1965)

Abstract The electronic spectra of aniline and N-methylaniline adsorbed on evaporated film of aluminum chloride have been measured (150–300 mμ for the former adsorbate and 185–300 mμ for the latter). In the case of N-methyl-aniline, a spectrum which is nearly the same as that of ethylbenzene has been obtained. In the case of adsorbed aniline, the spectrum shows features intermediate between those of the aniline vapor spectrum and those of the toluene vapor spectrum. These results can be interpreted in terms of the electron donation from the lone-pair electrons on the nitrogen atom of these molecules to some electron-accepting center on aluminum chloride, presumably to the vacant sp3-orbital of the aluminum atom on the surface, resulting in the weakening of the conjugation between the amino- (or N-methylamino-) group and the benzene ring. The positions of the absorption bands are interpreted qualitatively in terms of the relative location of charge-transfer and locally-excited configurations in these molecules.
Different Technetium Complexes with Mercaptoacetyltriglycine (1990)

Syntheses performed with unprotected mercaptoacetylglycylglycylglycine (MAG3) both at carrier level (10−4 M) and with no-carrier-added 99mTc indicated that various products of different biological properties exist in the Tc/MAG3 system. Besides the known Tc(V)oxo complex recently introduced into nuclear medicine for renal function diagnosis, mainly three species were characterized by HPLC, TLC, electrophoresis and uv-vis spectroscopy as well as biodistribution studies in minipigs. Alteration of preparation conditions such as concentrations, sequence of reactant addition, pH, and time enabled to elucidate reaction routes within the system, interdependence of the species, and vulnerability of the kidney imaging agent.
Performance analysis of parasitic effect on distributed spiral inductor for 0.15 &#x03BC;m GaAs pHEMT MMIC low noise amplifier (2012)

This paper presents the effect of measured distributed spiral inductor in monolithic microwave integrated circuit (MMIC) low noise amplifier (LNA) performance. Using S-parameter simulation, the LNA performance between lump and distributed circuit are compared at 2.4 GHz. The utilized measured spiral inductors are 0.37 nH, 5.29 nH and 6.7 nH. Noise figure (NF) performance of the LNA is measured. It is shown that the NF is increased by 0.69 dB when lump components are replaced with distributed components. It is also found that the gain is decreased by 6.35 dB while input-output return loss has decreased by 0.01 dB and 0.28 dB, respectively. From the results obtained, the spiral inductor has a noticeable impact on the LNA performance especially on the gain and noise figure. The parasitic effects including self-resonance on spiral inductor of 5.29 nH is also discussed. This analysis is essential to ensure the simulation results yield realistic measured results for the fabricated LNA. Therefore the designer will have a good estimation on the performance of the LNA during the design stage prior to the testing stage.
Production-Pressure-Drawdown Management for Fractured Horizontal Wells in Shale-Gas Formations (2017)

Summary The development of unconventional shale-gas formations in North America with horizontal multifractured wells is mature enough to identify production malpractices and abnormal productivity declines generally observed within 18–24 months of initial production. The primary objective of this study is to address all known causes of these productivity declines and to develop a fully coupled geomechanical/flow simulation model to simulate these production conditions. This model mimics the effect of depletion-induced in-situ stress variations on short-term and long-term productivity by taking into account several phenomena, such as stress-dependent matrix and natural-fracture permeability as well as reduction in hydraulic-fracture conductivity caused by proppant crushing, deformation, embedment, and fracture-face creep. Matrix-permeability evolutions, considering the conflicting effects of non-Darcy flow and compaction, have also been accounted for in this model. Numerical solutions for simplified hydraulic-fracture planar geometries are then obtained by use of a finite-element-method scheme. A synthetic case was defined to investigate the effects of each individual phenomenon on short-term and long-term production. Results show that the combined effects of permeability alterations in matrix and natural fractures as well as conductivity losses in hydraulic fractures may result in substantial cumulative-gas-production loss. The model also reproduces familiar field-observed trends, with lower long-term production corresponding to higher drawdowns. This behavior is attributed to the stress-dependent evolution of reservoir permeability and hydraulic-fracture conductivity. The results show that ignoring the effects of any of the previous phenomena results in overestimation of ultimate recovery. Furthermore, it is shown that proper management of pressure drawdown and the penalty for lower initial production rates in unconventional shale-gas reservoirs can yield substantially higher ultimate recovery. The model is fully versatile and allows modeling and characterization of all widely differing (on a petrophysical level) shale-gas formations as well as proppant materials used for the stimulation treatments. This integrated model can be used for optimization of key parameters during the hydraulic-fracture design, for fine tuning production history matching, and especially as a predictive tool for pressure-drawdown management.
A SYSTEM AND A DEVICE FOR ISOLATING CIRCULATING TUMOR CELLS FROM THE PERIPHERAL BLOOD IN VIVO (2015)

Circulating tumor cells (CTC) play a crucial role in disseminating tumors and in the metastatic cascade. CTCs are found only in small numbers, and the limited amount of isolated CTCs makes it impossible to characterize them closely. This paper presents a proposal for a new system for isolating CTCs from the peripheral blood in vivo. The system enables CTCs to be isolated from the whole blood volume for further research and applications. The proposed system consists of magnetic nanoparticles covered by monoclonal antibodies against a common epithelial antigen, large supermagnets, which are used to control the position of the nanoparticles within the human body, and a special wire made of a magnetic core wrapped in a non-magnetic shell. The system could be used not only for isolating CTCs, but also for in vivo isolation of other rare cells from the peripheral blood, including hematopoietic and/or mesenchymal stem cells, with applications in regenerative medicine and/or in stem cell transplantation.
Extension of root-MUSIC to non-ULA Array Configurations (2006)

In this paper we introduce a method for modelling the steering vector of an arbitrary array such that its steering vector can be expressed as the product of a characteristic matrix of the array itself and a vector with a Vandermonde structure containing the unknown parameter. We call this technique manifold separation. By exploiting this concept, we developed a novel version of the root-MUSIC algorithm for direction of arrival (DoA) estimation of sources. It can be applied to arbitrary 2-D array configurations. The proposed algorithm processes the data in element-space domain and does not require any transformation or array interpolation. The novel algorithm, named element-space root-MUSIC, provides computationally low complexity (search-free) DoA estimation and has close to CRB performance already at low SNRs
Measurement and Evaluation of Coal Sorption Isotherm Data (1990)

Abstract The proper measurement and interpretation of sorption isotherm data is of primary importance in understanding and predicting the gas production performance of a coalbed methane reservoir. These data are used to predict the release of gas from the reservoir as the pressure is reduced during production and the eventual gas recovery (reserves). A sorption isotherm is a laboratory measurement performed on a representative coal sample to determine the methane storage capacity as a function of pressure. The term "isotherm" results as the experiment is performed at a constant temperature which should be equal to that of the reservoir. This paper presents the use of the data, procedures for performing the measurements, a methodology for interpreting the experimental data for estimates of gas storage capacity and diffusion coefficients of the coal matrix, and isotherms obtained from a variety of coal samples.
Mechanical and sensory testing of overfilled breast implants (2006)

Saline-filled breast implants can be safely filled far beyond manufacturer's recommendations with regard to the mechanical properties of the Silastic polymer implant shell. Clinical judgment is required to avoid hardness due to overfill. Repeating this study using an in vivo incubation method is required to determine how overfill will affect implant shells over time in the harsh milieu of a biologic environment.
A role for the perlecan protein core in the activation of the keratinocyte growth factor receptor (2001)

Perlecan, a widespread heparan sulphate (HS) proteoglycan, is directly involved in the storing of angiogenic growth factors, mostly members of the fibroblast growth factor (FGF) gene family. We have previously shown that antisense targeting of the perlecan gene causes a reduced growth and responsiveness to FGF7 [also known as keratinocyte growth factor (KGF)] in human cancer cells, and that the perlecan protein core interacts specifically with FGF7. In the present paper, we have investigated human colon carcinoma cells in which the perlecan gene was disrupted by targeted homologous recombination. After screening over 1000 clones, we obtained two clones heterozygous for the null mutation with no detectable perlecan, indicating that the other allele was non-functioning. The perlecan-deficient cells grew more slowly, did not respond to FGF7 with or without the addition of heparin, and were less tumorigenic than control cells. Paradoxically, the perlecan-deficient cells displayed increased FGF7 surface binding. However, the perlecan protein core was required for functional activation of the KGF receptor and downstream signalling. Because heparin could not substitute for perlecan, the HS chains are not critical for FGF7-mediated signalling in this cell system. These results provide the first genetic evidence that the perlecan protein core is a molecular entity implicated in FGF7 binding and activation of its receptor.
Nutrient Regulation of Skeletal Muscle Protein Metabolism in Animals. The Involvement of Hormones and Substrates (1995)

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Prediction of spatially variable unsaturated hydraulic conductivity using scaled particle‐size distribution functions (2013)

Simultaneous scaling of soil water retention and hydraulic conductivity functions provides an effective means to characterize the heterogeneity and spatial variability of soil hydraulic properties in a given study area. The statistical significance of this approach largely depends on the number of soil samples collected. Unfortunately, direct measurement of the soil hydraulic functions is tedious, expensive and time consuming. Here we present a simple and cost‐effective hybrid scaling approach that combines the use of ancillary information (e.g., particle‐size distribution and soil bulk density) with direct measurements of saturated soil water content and saturated hydraulic conductivity. Our results demonstrate that the presented approach requires far fewer laboratory measurements than conventional scaling methods to adequately capture the spatial variability of soil hydraulic properties.
578 Free2B: bridging the gap between theory, practice (2016)

<h3>Background</h3> Urban minority youth are disproportionately exposed to violence, a factor that perpetuates disparities in education, incarceration, and social/behavioural problems. Involvement in bullying in early adolescence has been associated with maladaptive outcomes as youth enter young adulthood. Combining state-of-the-art interactive technology, a strong theoretical foundation and a partnership-based approach with urban youth and educators, initial studies of Free2B will be examined to determine its relevance, acceptability, and initial effectiveness for urban 7th and 8th graders. <h3>Methods</h3> The program theory explicates how the primary intervention components (3D film, inspirational videos and an interactive quiz show) are thought to impact both proximal (e.g., knowledge of bullying facts; prosocial attitudes about positive bystander behaviour) and distal (e.g., increases in positive bystander behaviour and collective action to prevent bullying) outcomes over time. <h3>Results</h3> Data from 268 7th and 8th grade ethnic minority youth from two North American urban schools will be presented. Over 90% of students found the program to be acceptable and feasible. In addition, paired sample t-tests also suggest that Free2B enhanced students’ social problem-solving knowledge, prosocial attitudes about bullying, and confidence in resolving conflicts. In addition, data has just been collected from ten additional schools across both urban and suburban contexts in order to better understand program applicability for a more diverse set of school contexts. <h3>Conclusions</h3> Free2B highlights how researchers can collaborate with multi-media experts to develop engaging and scientifically-grounded injury prevention programs that can relevance for diverse urban and potentially suburban settings. Challenges for researchers in trying to bridge the gap between theory, practice, and innovation will be highlighted.
Refinement of the Cast Microstructure of Hypereutectic Aluminum-Silicon Alloys with an Applied Electric Potential (2012)

BACKGROUND AND PURPOSE: Hypereutectic aluminum-silicon (Al-Si) alloys are widely used in the aerospace and automobile industries because of their low density, excellent wear and corrosion resistance, low coefficient of thermal expansion, good strength, and excellent castability. They are used in applications that typically require a combination of light weight and high wear resistance, such as liner-less engine blocks, pistons, and pumps. However, the performance of these alloys depends on the fineness of their cast microstructure, especially dendrite cell size, primary and eutectic Si particles. METHODS AND MATERIALS: In this study, the effects of applied electric current on the cast microstructure of Al-13 wt.%Si and Al-20 wt.%Si were investigated. This involved application of an electric current density of about 500 mA/cm2 of melt surface area during solidification of laboratory-size ingots in a metal mold. The electric current was applied with a constant voltage power supply. RESULTS: Microscopic examination of the cast ingots with a metallurgical microscope revealed that the applied electric refined the cast microstructure of the hypereutectic Al-Si alloys. Specifically, it appeared that the electric current slightly modified the eutectic silicon particles and changed the size distribution of the primary silicon particles by increasing the population of comparatively smaller size particles. CONCLUSIONS: The extent of the observed cast microstructure refinement was less than the reported effects of applied electric current in technical literature. It was also significantly less than the effects of traditional refinement obtained by addition of strontium and phosphorus to the molten hypereutectic Al-Si alloys prior to casting.
Some Reactions of Levopimaric Acid Dioxide (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Reactions of Levopimaric Acid DioxideHideo Kanno, Walter H. Schuller, and Ray V. LawrenceCite this: J. Org. Chem. 1966, 31, 12, 4138–4142Publication Date (Print):December 1, 1966Publication History Published online1 May 2002Published inissue 1 December 1966https://pubs.acs.org/doi/10.1021/jo01350a061https://doi.org/10.1021/jo01350a061research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of Guanine Nucleotides on Complex Formation between Ras and CDC25 Proteins (1993)

The Saccharomyces cerevisiae CDC25 gene and closely homologous genes in other eukaryotes encode guanine nucleotide exchange factors for Ras proteins. We have determined the minimal region of the budding yeast CDC25 gene capable of activity in vivo. The region required for full biological activity is approximately 450 residues and contains two segments homologous to other proteins: one found in both Ras-specific exchange factors and the more distant Bud5 and Lte1 proteins, and a smaller segment of 48 amino acids found only in the Ras-specific exchange factors. When expressed in Escherichia coli as a fusion protein, this region of CDC25 was found to be a potent catalyst of GDP-GTP exchange on yeast Ras2 as well as human p21H-ras but inactive in promoting exchange on the Ras-related proteins Ypt1 and Rsr1. The CDC25 fusion protein catalyzed replacement of GDP-bound to Ras2 with GTP (activation) more efficiently than that of the reverse reaction of replacement of GTP for GDP (deactivation), consistent with prior genetic analysis of CDC25 which indicated a positive role in the activation of Ras. To more directly study the physical interaction of CDC25 and Ras proteins, we developed a protein-protein binding assay. We determined that CDC25 binds tightly to Ras2 protein only in the absence of guanine nucleotides. This higher affinity of CDC25 for the nucleotide-free form than for either the GDP- or GTP-bound form suggests that CDC25 catalyzes exchange of guanine nucleotides bound to Ras proteins by stabilization of the transitory nucleotide-free state.
Titanium density analysed by optical absorption and emission spectroscopy in a dc magnetron discharge (2007)

This paper presents an optical diagnostic examination of dc planar magnetron discharge used for titanium deposition at 30 mTorr in argon bulk gas. The results were obtained by optical absorption (OAS) and emission (OES) spectroscopy for two distances from the target without substrate. The absolute density of titanium in the ground and metastable states at 4 cm from the target ranged, respectively, between 8 × 1010 cm−3 and 1012 cm−3 and between 6 × 1010 cm−3 and 3 × 1011 cm−3, in the range 0.2–1.0 A. OES results were used to prepare an assumed interpretation in terms of differences in loss mechanisms, mainly by either diffusion towards the walls for all particles at 8 cm from the target or collision losses for non-radiative species at 4 cm from the target, except for the titanium ground state. This was confirmed by our results of the argon metastable density measurement at 4 cm which was constant at around 7 × 1010 cm−3 with discharge current.
Light and plastid signals regulate the expression of the pea plastocyanin gene through a common region at the 5′ end of the coding region (2005)

Expression of the pea plastocyanin gene (PetE) is regulated by light and plastid signals. Previous work indicated that light and plastid regulation of pea PetE operates post-transcriptionally in transgenic tobacco, and requires the correct 5' terminus of the PetE transcript and the PetE-coding region. The post-transcriptional light and plastid regulation of pea PetE has now been demonstrated to operate in transgenic Arabidopsis, where in contrast the endogenous PETE gene is regulated transcriptionally. Transgenic tobacco seedlings containing constructs with progressive 3' deletions of the PetE-coding region fused to the luciferase (Luc) reporter gene demonstrate that the first 60 nucleotides of the coding region are sufficient for regulated accumulation of Luc transcripts by light and plastid signalling pathways affected by treatment with norflurazon and lincomycin. PetE constructs containing premature stop codons were generated to investigate whether translation has a role in light or plastid regulation. Insertion of a stop codon in place of the second codon of the PetE-coding region diminished both light and plastid regulation of PetE transcripts, whereas stop codons inserted later in the transcript had no effect on light or plastid regulation. These experiments indicate that the 5' end of the plastocyanin-coding region contains sequences important for regulation by light and plastid signals.
The radiosensitizing effect of fluorocyclopentenyl-cytosine (RX-3117) in ovarian and lung cancer cell lines (2016)

RX-3117 (fluorocyclopentenyl-cytosine) is a novel cytidine analog currently being evaluated in a Phase Ib clinical trial in cancer patients with solid tumors. The radiosensitizing effect of RX-3117 was studied in A2780 ovarian cancer cells and non-small cell lung cancer cell lines and related to cell survival and the effect on cell cycle and cell cycle proteins. RX-3117 has a schedule-dependent radiosensitizing effect, but only at pre-incubation (dose modifying factors: 1.4-1.8), observed at pulse and fractionated irradiation. Radiosensitizion was also seen in a three-dimensional spheroid model. At the low radiosensitizing concentration, RX-3117 in combination with radiation led to an accumulation of cells in S-phase, which was accompanied with an increase of cell cycle proteins such as p-Chk2 and p-cdc25C. In addition, RX-3117 caused DNA damage and increased apoptosis. In conclusion, our in vitro experiments showed a radiosensitizing effect of RX-3117.
Effective strategies for choosing and locating printed circuit board decoupling capacitors (2006)

Power bus decoupling is an important part of digital printed circuit board design. Effective strategies for implementing power bus decoupling depend on the board construction as well as the demands that the circuits place on the power distribution network. This paper discusses strategies for locating and mounting decoupling capacitors in various situations as well as methods for estimating the total amount of decoupling capacitance required
STIMULATED EMISSION FROM FLASHLAMP-EXCITED ORGANIC DYES IN POLYMETHYL METHACRYLATE (1968)

Laser emission is reported from flashlamp-excited polymethyl methacrylate rods containing rhodamine dyes. Quenching of stimulated emission by the molecular triplet state is apparently reduced in the solid with respect to that observed for the same dyes in liquid solution.