gebhart/patrepeval huggingface dataset:
Oxidative stress and early organ damage in essential hypertension (2001)

The objective was to evaluate the relationship between the oxidative status, the extent of DNA oxidation and markers of early organ damage in essential hypertensive patients. Forty-one essential hypertensive subjects (mean age 48 yr, 24 males, SBP 160±18 mmHg, DBP 97±12 mmHg) were included. In absence of antihypertensive treatment, 24-hour urinary albumin excretion (UAE mg/24h) and left ventricular mass index (LVMI g/m) were measured. In whole blood and in lymphocites, oxidative stress status (GSSG/GSH) and DNA-damage (8-oxo-2'-deoxyguanosine only in lymphocites) were assessed. When subjects were divided in tertiles of GSSG/GSH, in whole blood or in lymphocites, the highest tertiles shown higher values of UAE (17.6±6; 19.3±5 and 80.7±44 mg/24h) and higher LVMI (84.4±10; 62.7±4.4 and 104.0±16.3 g/m) than those observed in the two other tertiles. No differences among groups were observed in the 24-hour ambulatory MBP (102±12; 106±7 and 107±20 mmHg). Likewise, subjects in the highest tertile of 8-oxo-2'-deoxyguanosine shown the highest LVMI as compared to the two other tertiles (74±23; 71±23 and 106±51 g/m) in absence of differences in the 24-hour ambulatory MBP (108±11; 106±19 and 103±13 mmHg). Conclusion: Hypertension-induced early organ damage, in part independent to BP values, was related to the oxidative stress levels.
Estimating Behind-the-meter Solar Generation with Existing Measurement Infrastructure (2016)

Real-time PV generation information is crucial for distribution system operations, in particular for switching operations, state-estimation, and management of the voltage at the point of provision. However, most behind-the-meter solar installations are not monitored. Typically, the only information available to the distribution system operator is the installed capacity. Our main purpose in this study is to estimate behind-the-meter PV generation using data from smart meters.
Acute‐phase proteins in perinatal human plasma (1997)

Plasma from eight newborns (4 pre-term and 4 full-term) with early-onset (< 72 h) sepsis and six apparently healthy controls was analyzed. The presence of spots identified as haptoglobin and serum amyloid A protein was the electrophoretic result most consistently associated with disease. Time course monitoring showed rises, peaks and declines of spot intensity as expected for acute-phase proteins induced by transient stimuli. Haptoglobin beta chains appear to be undersialated in pre-term newborns, whereas post-translational modifications of alpha chains and serum amyloid A protein are similar to those observed in adults. The undersialation of beta chain and occurrence of alpha chain phenotypes different from those found in maternal serum indicate that perinatal haptoglobin originates from neonatal synthesis.
Multi-dimensional DFT beamspace SAGE super-resolution algorithm (2003)

A novel multi-dimensional frequency domain SAGE (space-alternating generalised expectation-maximisation) algorithm in DFT beamspace for estimating channel parameters is presented. In contrast to the classical implementation of the SAGE algorithm in element space, the proposed algorithm allows the estimates of each parameter to be optimised within a smaller domain. Further reduction in the computational complexity within each SAGE iteration is achieved since the alternating parameters in the correlation process are in the real-valued domain. A major advantage of the proposed algorithm is its ability for mapping onto parallel processors. The general implementation of the proposed algorithm with efficient matrix computation is presented, with conditions necessary for achieving the best performance stated. Finally, its performance is evaluated by using real channel measurement data.
VISIBLE LASER DEPOSITION OF METALS ON TRANSPARENT SUBSTRATES (1985)

Laser photochemical or thermochemical deposition of metallic films on transparent substrates such as glass or quartz has proven commercially useful and scientifically interesting. The transparent substrate facilitates the use of powerful optical techniques to probe fundamental deposition parameters while a major commercial application is the repair of clear defects in photomasks. The lasers chosen for such studies have typically been either ultraviolet (usually frequency-doubled argon) or infrared (CO2). UV lasers offer high resolution but necessitate the use of costly and often difficult to obtain quartz or reflective optics, IR lasers offer limited resolution and also require specialized optics.
Synthesis of 1-Phenylpropane Derivatives. I<sup>1</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 1-Phenylpropane Derivatives. I1Takeshi Matsumoto and Kunio HataCite this: J. Am. Chem. Soc. 1957, 79, 20, 5506–5508Publication Date (Print):October 1, 1957Publication History Published online1 May 2002Published inissue 1 October 1957https://pubs.acs.org/doi/10.1021/ja01577a048https://doi.org/10.1021/ja01577a048research-articleACS PublicationsRequest reuse permissionsArticle Views291Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Marine pharmacology in 1999: antitumor and cytotoxic compounds. (2001)

During 1999 marine antitumor pharmacology research involved researchers in Austria, Australia, England, France, Germany, Greece, Holland, Italy, Japan, Spain, Taiwan and the United States. Thirty six papers were published in peer-reviewed journals describing the antitumor and cytotoxic properties of 30 marine natural products belonging to four structural types, namely polyketides, terpenes, nitrogen-containing compounds and polysaccharides. The organisms yielding these bioactive marine compounds comprised a diverse group of marine animals, algae, fungi and bacteria. A variety of antitumor pharmacological studies were conducted with 17 marine natural products with established mechanisms of action in a number of experimental and clinical models. Didemnin B, a tunicate-derived depsipeptide with potent antitumor effects, completed a Phase II anticancer clinical trial which resulted indeterminate in respect to activity against human melanoma due to anaphylactoid reactions. In vitro cytotoxicity data with murine and human cell lines were reported for 14 novel marine chemicals with as yet undetermined mechanisms of action. This 1999 literature overview thus highlights the fact that the multinational effort aimed at the discovery of novel marine antitumor agents remained at the same level of research activity as during 1998.
Power grid defense against malicious cascading failure (2014)

An adversary looking to disrupt a power grid may look to target certain substations and sources of power generation to initiate a cascading failure that maximizes the number of customers without electricity. This is particularly an important concern when the enemy has the capability to launch cyber-attacks as practical concerns (i.e. avoiding disruption of service, presence of legacy systems, etc.) may hinder security. Hence, a defender can harden the security posture at certain power stations but may lack the time and resources to do this for the entire power grid. We model a power grid as a graph and introduce the cascading failure game in which both the defender and attacker choose a subset of power stations such as to minimize (maximize) the number of consumers having access to producers of power. We formalize problems for identifying both mixed and deterministic strategies for both players, prove complexity results under a variety of different scenarios, identify tractable cases, and develop algorithms for these problems. We also perform an experimental evaluation of the model and game on a real-world power grid network. Empirically, we noted that the game favors the attacker as he benefits more from increased resources than the defender. Further, the minimax defense produces roughly the same expected payoff as an easy-to-compute deterministic load based (DLB) defense when played against a minimax attack strategy. However, DLB performs more poorly than minimax defense when faced with the attacker's best response to DLB. This is likely due to the presence of low-load yet high-payoff nodes, which we also found in our empirical analysis.
Clinical results of one-stage urethroplasty with parameatal foreskin flap for hypospadias. (2005)

We investigated the usefulness of one-stage urethroplasty by the parameatal foreskin flap method (OUPF procedure), which is useful for repairing all types of hypospadias. Between June 1992 and March 2001, the OUPF procedure was performed on 18 patients with hypospadias: 10 patients with distal and 8 with proximal hypospadias. The follow-up periods ranged from 33-75 months, with an average of 52 months. The duration of surgery, the catheter indwelling period, and the postoperative complications of each patient were analyzed. The median age of the patients at the time of surgery was 3 years and 8 months. The length of surgery for OUPF II ranged from 150-230 min (average 186 min), and from 190-365 min (average 267 min) for OUPF IV. Postoperative complications were confirmed in 3 of the 18 patients (16.6%). Two patients had fistulas, and one had a meatal regression. The fistulas were successfully closed by the simple multilayered closure method. After adopting DuoDerm dressings instead of elastic bandages for protection of the wound, no fistulization occurred. DuoDerm dressings are useful in the healing of wounds without complications. To date, the longest follow-up period has been 75 months, and during that time there have been no late complications such as urethral stenosis or penile curvature. OUPF is a useful method in the treatment of hypospadias with a low incidence of early and late complications.
Randomized trial of administration of prostaglandin E2 gel for induction of labor in the morning or the evening (2000)

There was no benefit in starting induction of labor with prostaglandin E2 in the evening, compared with starting in the morning.
MOLECULAR FATE OF HETEROLOGOUS BACTERIAL DNA IN COMPETENT <i>BACILLUS SUBTILIS</i>. II. UNSTABLE ASSOCIATION OF HETEROLOGOUS DNA WITH THE RECIPIENT CHROMOSOME (1982)

In CsCl density gradients of lysates from competent Bacillus subtilis cells, which had been exposed to heterologous bacterial DNA, very little donor-recipient complex (DRC) formation could be detected. The present study demonstrates that photocrosslinking of such lysates by irradiation with long-wave UV light in the presence of 4,5',8-trimethylpsoralen results in a dramatic increase in the amount of heterologous DRC. This phenomenon may be interpreted as the stabilization of a pre-existing weak association between entered heterologous donor DNA and one recipient strand in unpaired regions of the chromosome. When a recombination-deficient mutant is used, the amount of stabilizable heterologous DRC is reduced to the same extent as the specific transforming activity of homologous DNA. Although the amount of stabilizable complex is related to the degree of homology between donor and recipient DNA, this relation is not a quantitative one. Probably the association is caused by very short regions of base pairing between the donor and recipient moieties in the complex. Heating of a lysate at 70 degrees prior to photocrosslinking prevents stabilization, apparently because the regions of base pairing are rapidly melted out. The results described in this paper can be best interpreted as the fixation of a process in which entered donor DNA in competent cells tries to find homologous stretches in the recipient chromosome.
A Role in Migration for the αVβ1 Integrin Expressed on Oligodendrocyte Precursors (1996)

Conference Abstract| July 01 1996 A Role in Migration for the αVβ1 Integrin Expressed on Oligodendrocyte Precursors R Milner; R Milner 1Wellcome/CRC Institute, University of Cambridge, CB2 1QR, U.K. Search for other works by this author on: This Site PubMed Google Scholar G Edwards; G Edwards 1Wellcome/CRC Institute, University of Cambridge, CB2 1QR, U.K. Search for other works by this author on: This Site PubMed Google Scholar C Streuli; C Streuli 1Wellcome/CRC Institute, University of Cambridge, CB2 1QR, U.K. Search for other works by this author on: This Site PubMed Google Scholar C-Constant Ffrench C-Constant Ffrench 1Wellcome/CRC Institute, University of Cambridge, CB2 1QR, U.K. Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1996) 91 (s35): 18P. https://doi.org/10.1042/cs091018P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation R Milner, G Edwards, C Streuli, C-Constant Ffrench; A Role in Migration for the αVβ1 Integrin Expressed on Oligodendrocyte Precursors. Clin Sci (Lond) 1 July 1996; 91 (s35): 18P. doi: https://doi.org/10.1042/cs091018P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1996 The Biochemical Society and the Medical Research Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Fast techniques for determining myocardial strains from tagged MRI (2000)

Summary form only received. Magnetic resonance (MR) tagging is a useful technique for noninvasively measuring the deformation of the heart. With MR tagging, quantitative measurement of heart motion can be obtained from the motion of a set of dark lines encoded within the deforming Left-Ventricular (LV) tissue. However, these tag lines are sparse and therefore techniques are needed to reconstruct a dense displacement field at all points within the LV myocardium so that mechanical indices of function such as strain, shear, and torsion can be determined for all myocardial points. Here, a subspace approximation technique is used to accomplish this task. First, the authors formulate the displacement estimation as a variational problem and then a subspace approximation method which makes use of B-spline bases is proposed to approximate the solution. By taking advantages of B-spline properties, efficient numerical methods are derived which reconstruct the motion field within a short-axis MRI slice in under one minute. The methods have been extensively validated using both simulated and in-vivo data in animal models and patients.
Machine learning and the auditory nerve (2004)

The application of machine learning to the auditory system is studied. The application consists of four models such as model of the normal auditory system, impaired auditory system, processing block to train, and an error metric. The statistical differences between the normal and impaired auditory nerve reponses shows a loss of contrast between different auditory landmarks. It is expected that better segmentation will lead to more normal streaming, allowing the hearing-aid user the ability to unmask spectrally and temporally and also a normal hearing person.
Significance of Mild Transient Release of Creatine Kinase–MB Fraction After Percutaneous Coronary Interventions (1996)

This study shows that minor elevations of CK-MB after successful coronary interventions identify a population with a worse long-term prognosis compared with patients with no enzyme elevations and appear to have an adverse effect on long-term prognosis. Future studies of percutaneous coronary revascularization should include routine measurements of biochemical cardiac markers as important predictors of long-term prognosis.
Microwave-Assisted Solvothermal Synthesis of CuInSe<SUB>2</SUB> Chalcopyrites (2010)

Chalcopyrite, CuInSe2 was prepared by a fast microwave-assisted solvothermal synthesis. The influence of reaction temperature, concentrations of the constituents, types of copper salts and added solvent on the morphology and crystallinity of the chalcopyrite has been investigated and also the optimized parameters are presented. The optimum crystallinity was obtained at 180 degrees C reaction temperature with 0.02 M of copper ion concentration. Interestingly, when the copper acetate was used as a copper source, particle size of chalcopyrite was dramatically reduced. Moreover, the synthesis at 1L scale of the reactants gave the particle size of 20 nm for CuInSe2 which is smaller than that of small scale synthesis (23-35 nm). XRD, SEM and Raman Spectroscopy techniques are used for characterization and evaluation of the morphology of the chalcopyrite.
Check Out These Books (2002)

The book entitled Leadership: Unlocking the Subtle Forces that Change People and Organizations Richard L. Daft and Robert H. Lengel (1998) Berett-Koehler Publishers, Inc. was Reviewed by Dr. Michelle Collins, NASA Headquarters. If you've already read books on leadership and organizational change by authors such as Moshe Rubinstein and Iris Firstenberg, Peter Senge, Tom Peters, and Steven Covey, and you were thinking of rereading them, you don't have to do that now. Just read this book instead. It's a fusion of many of their same concepts presented from a different view. The book does not explore any particular subject in depth. Rather the authors skim many subjects and concepts, interlacing them to develop the concept of Leadership. The fundamental concept of treating people as people rather than machines is the main theme. is the process of fusing people together by nurturing six subtle forces: mindfulness, courage, vision, heart, communication, and integrity. To do so, hierarchy is diminished and responsibility both for oneself as well as for the team is emphasized. There are a number of organizations and managers that will find such a change threatening. The concepts behind such a management style are straightforward and the benefits are intuitive once you've reflected on them; however, the obvious benefits of the behavioral change proposed in Fusion Leadership can be completely lost in a fear-based system. The concept of caring about people in one's organization was the common thread in Chris Turner's book All Hat, No Cattle (see book review, ASK 5). Much is being written about the re-humanizing of the workplace, but the basis of it is so common sense that one wonders what's taking so long for the workplace to change? Whether you're in a position to change your organization or simply your project team, you'll find the concepts in fusion leadership equally applicable.
351: Chronic Graft-Versus-Host Disease (CGVHD) Following Sibling Donor Peripheral Blood Stem Cell Transplant (PBSCT) Versus Bone Marrow Transplant (BMT): Greater Incidence and Longer Duration of Immune-Suppression (DIS) using PBSC (2008)

Chronic graft-versus-host disease (CGVHD) is more frequent following peripheral blood stem cell (PBSCT) than bone marrow transplantation (BMT). However, the responsiveness of the disease to immune-suppression using either stem cell source has not been well validated. We compared the time to discontinuation of immune-suppression between PBSCT and BMT in 184 patients with CGVHD after sibling donor transplantation. Of 717 sibling donor transplants (1990–2004), the cumulative incidence of CGVHD was 25% (95% CI 22–28%) overall and was more frequent after PBSCT [39% (95% CI 32–46%) versus BMT 17% (95% CI 14–20%), p < 0.01]. The incidence of discontinuation of immune-suppression (DIS) was 9% (95% CI 5–13%) at 1 year, and 67% (95% CI 52–82%) by 5 years [DIS at 1 year: BMT 15% (95% CI 7–23%) versus PBSCT 5% (95% CI 1–9%); and at 2 years: 38% (95% CI 26–50%) versus 32% (95% CI 22–42%); however both approached 67% by 5 years]. The multivariate analysis was restricted to adult patients who received myeloablative conditioning (n = 130, 63 BMT, 67 PBSCT) due to interaction between pediatric age group and stem cell source (17/19 pediatric patients received BMT); and conditioning regimen and stem cell source (35/37 receiving non myeloablative conditioning regimen also received a PBSCT). PBSC recipients, those with progressive onset of CGVHD and thrombocytopenia (<100,000/μl) at diagnosis of CGVHD had lower rates of DIS than BM recipients (Table). After a median follow-up of 33 months, a trend towards superior overall survival at 5 years was seen in the BMT cohort [5 year survival: BMT 65% (95% CI 53–75%) versus PBSCT 58% (95% CI 45–69%) p = 0.07]. Following sibling donor transplantation, CGVHD is more frequent and more resistant to immune-suppressive therapy using PBSC vs. BM. PBSC recipients were significantly more likely to require prolonged immune-suppression and extended morbidity from CGVHD. Careful attention to this serious later morbidity and mortality should guide clinical decisions about the use of either BM or PBSC sources for sibling donor transplantation.Tabled 1Time to Discontinuation of Immune SuppressionHazard Ratio (95% C.I.) (>1 = more frequent/quicker DIS)PStem Cell Source Marrow1.0<0.01 PBSC0.5 (0.3–0.8) Onset of CGVHD Quiescent/Denovo1.00.01 Progressive0.5 (0.3–0.7)No. of Organs involved with GVHD 11.0 20.8 (0.4–1.4)0.29 3+0.7 (0.3–1.3)0.21Thrombocytopenia <100,000/μL1.0<0.01 ≥100,000/μL2.0 (1.3–3.3)Overall Survival [Kaplan-Meier estimate (95% CI)], p = 0.07MarrowPBSCAt 2 years77% (66–84%)70% (60–78%)At 5 years65% (53–75%)58% (45–69%) Open table in a new tab
A Videotape Module to Teach Assertion Skills<sup>1</sup> (2003)

A LifeSkills© video module to teach assertion has been developed that uses dramatizations of the effective and ineffective ways to respond to a provocation. Normal volunteers were randomly assigned to watch the assertion video ( n = 50) or a control instructional video ( n = 53). Participants completed pre‐/post‐assessment batteries that tested their knowledge of the steps of assertion and their ability to apply this knowledge in response to 3 written scenarios. The answers were scored for both the presence of aggression and the use of assertion. Participants randomized to the assertion video showed larger increases in assertion and decreases in aggression compared to controls, indicating that a video dramatizing the use of assertion can be a practical and effective means of improving assertion skills, with decreased aggression a potential added benefit.
Ruthenium-mediated cyclodimerisation of buta-1,3-diene (1996)

Treatment of solvated Ru2+ ions in acetone solution with a large excess of buta-1,3-diene results in the formation of the unusual cyclooctatriene/cyclooctadienyl complex [Ru(η6-C8H10)(1-3:5-6-η-C8H11)]+ 1 derived from the cyclodimerisation and dehydrogenation of two pairs of butadiene molecules at the metal center.