gebhart/patrepeval huggingface dataset:
Inhibitors of Tyrosine Kinase Signaling Cascade Attenuated Antigen Challenge of Guinea-Pig Airways <i>In Vitro</i> (2000)

Activation of nontransmembrane protein tyrosine kinases (PTKs), phosphatidylinositol 3-kinase (PI3K), and mitogen-activated protein kinase (MAPK) has been shown to be responsible for high-affinity Fc receptor (Fcepsilon RI)-mediated mast cell degranulation. Effects of inhibitors of the PTK signaling cascade on ovalbumin (OA)-induced anaphylactic contraction of isolated guinea-pig bronchi and release of histamine and peptidoleukotrienes from chopped lung preparations were studied. Genistein (30 microM) and tyrphostin 47 (50 microM), two PTK inhibitors, as well as LY294002 (10 microM), a selective PI3K inhibitor, significantly reduced (p < 0.05) peak anaphylactic bronchial contraction and facilitated relaxation of the contracted bronchi. PD 098059 (30 microM), a selective MAPK kinase inhibitor, failed to suppress OA-induced peak bronchial contraction, but facilitated the relaxation of the contracted bronchi (p < 0.05). At the same concentrations, none of these inhibitors showed any inhibitory effects on histamine-, leukotriene D(4) (LTD(4))- or KCl-induced bronchial contraction. On the other hand, these inhibitors significantly prevented (p < 0.05) OA-induced release of both histamine and peptidoleukotrienes from chopped lung preparations. In addition, combined PD 098059 and LY294002 treatment markedly (p < 0.05) suppressed the peak anaphylactic bronchial contraction and facilitated relaxation of the contracted bronchi. The combination of these two inhibitors further inhibited the release of peptidoleukotrienes from chopped lung preparations. Taken together, our data show that inhibition of tyrosine kinase signaling cascade can markedly attenuate anaphylactic contraction of airways, probably via inhibition of mast cell degranulation, and that inhibitors of this signaling cascade may have therapeutic potential for the treatment of asthma.
Memantine in Behavioral Variant Frontotemporal Dementia: Negative Results (2011)

We tested the efficacy and tolerability of one-year treatment with memantine (10 mg bid) in behavioral variant frontotemporal dementia (bvFTD). BvFTD patients aged 45 to 75 years, with a Mini-Mental Status Examination (MMSE) score ≥19, were enrolled in a national, randomized, double-blind, placebo-controlled (DBPC), Phase II trial. The primary endpoint was the CIBIC-Plus (Clinician's Interview-Based Impression of Change Plus Caregiver Input). The secondary endpoints included: Neuropsychiatric Inventory (NPI), Frontal Behavioral Inventory (FBI), Mattis Dementia Rating Scale (MDRS), MMSE, Disability Assessment for Dementia (DAD), and the Zarit Burden Inventory (ZBI). Forty-nine patients were analyzed. At baseline, mean age was 65.6 years and mean MMSE was 25.0 (range: 19-30). On the CIBIC-Plus, 52 weeks after baseline, there were no significant differences between the memantine group (n = 23) and the placebo group (n = 26); p = 0.4458; however, 10 patients had worsened in the memantine group versus 17 in the placebo group. For the secondary endpoints there were no differences in the evolution of score between the memantine group and the placebo group (MMSE, p = 0.63); (MDRS, p = 0.95); (NPI, p = 0.25); (ZBI, p = 0.43); (DAD, p = 0.10) except for the FBI score, which was lower in the memantine group (p = 0.0417). Memantine was well-tolerated. This is the first DBPC trial in a large group of bvFTD patients involving neuroprotective treatment. A multinational study with a larger number of patients is now needed in order to verify the results of our study. The trial is registered with ClinicalTrials.gov; number NCT 00200538.
Dielectrophoretic Cell Concentrator on EWOD-Based Chips (2006)

Dielectrophoretic concentrators were successfully developed on a EWOD-based chip. In such a chip, two major electrokinetic forces were exerted on objects on different scales. EWOD is used to pump droplets on a mm scale, while DEP manipulates bio-particles on a mum scale. Both cells and polystyrene beads were used to demonstrate the concentration abilities by pDEP and nDEP forces, respectively. Since electrodes are covered with a dielectric layer, instead of creating non-uniform electric fields in the liquid, low frequency signals are consumed in the dielectric layer and providing EWOD. It is necessary to use high frequency signals to generate DEP on a EWOD-based chip. Concentration efficiency, measured by cell count chamber before and after experiments, is around 1.62 with single cycle of pDEP attraction
Causation and disease: the Henle-Koch postulates revisited. (1976)

The Henle-Koch postulates are reviewed in terms of their full validity in Koch's day and in light of subsequent developments. The changing guidelines developed for viral diseases, for viruses in relation to cancer and to chronic central nervous system infection, and for causative agents in chronic diseases are discussed chronologically. A set of guidelines for both acute infectious and chronic diseases is presented. The need for recognizing the role of the host and the spectrum of host responses, for sound biologic sense in evaluating causal roles of agents in disease, and for flexibility in adapting our guidelines to new knowledge are emphasized.
Offline Signature Verification Using Graph Matching (2007)

In this paper, we present a simple and effective signature verification method that depends only on the raw binary pixel intensities and avoids using complex sets of features. The method looks at the signature verification problem as a graph matching problem. The method is tested using genuine and forgery signatures produced by five subjects. An equal error rate of 26.7% and 5.6% was achieved for skilled and random forgeries, respectively. A positive property of our algorithm is that the false acceptance rate of random forgeries vanishes at the point of equal false rejection and skilled forgery false acceptance rates. Keeping the normalization size at 32 x 64 pixels makes the verification time in the two seconds range.
Formulating water based epoxide paints (1985)

Thomas Swan & Co Ltd have for many years offered a range of water dispersible epoxide curing agents. These products are better known as the Casamid 360 range — water soluble modified polyamide curing agents, consisting of the following range:
All-optical modulation of 40 GHz beat frequencyconversion soliton source (1995)

The authors report the first error-free direct optical modulation of 40GHz pulses generated by a low-jitter beat frequency to soliton train conversion source.
Bioactive γ-Lactones from the Fermented Broth of<i>Neosartorya</i>sp. (2010)

Two γ-lactone derivatives, namely neosartolactone (1) and its 7-methyl ester analogue (2), have been isolated from the ethyl acetate extract of the fermented broth of Neosartorya sp. isolated in Taiwan. Structural elucidations of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. Although they had been obtained via the chemical modification of avenaciolide isolated from Aspergillus avenaceus several decades ago, this is the first report to describe them from a natural resource with detailed spectroscopic interpretations. The effects of 1 and 2 on the inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophages were further evaluated. Compounds 1 and 2 significantly inhibited NO production with the IC(50) values of 12.2 ± 1.5 and 11.4 ± 1.0 µM, respectively; but displayed cytotoxicity at considerably higher concentrations than 50 µM.
New AC/DC converter considering both inrush current limitation and start-up time (2013)

The main theme of this paper is to present a new AC/DC converter considering both inrush current limitation and start-up time. The presented converter consists of conventional power factor corrector, an auxiliary circuit and additional power device, e.g. MOSFET, which is connected in series with bulky capacitor of PFC. The power device operates in linear region during start-up process in order to limit inrush current and is fully turned on (i.e. in triode region) to reduce conduction power loss after start-up. The effectiveness of the proposed new AC/DC converter, including inrush current limitation and start up time improvement, will be confirmed by simulation and experimental results. It will be shown that the inrush current is 2A and startup time is less than 1 sec for 450 W AC/DC converter with input voltage = 230 V and output voltage = 12V.
Abstract: Effects of the bias voltage on the properties and structure of sputtered and ion-plated coatings (1974)

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Fast, Antigen-Saving Multiplex Immunoassay To Determine Levels and Avidity of Mouse Serum Antibodies to Pertussis, Diphtheria, and Tetanus Antigens (2011)

To enhance preclinical evaluation of serological immune responses to the individual diphtheria, tetanus, and pertussis (DTP) components of DTP combination vaccines, a fast hexavalent bead-based method was developed. This multiplex immunoassay (MIA) can simultaneously determine levels of specific mouse serum IgG antibodies to P antigens P.69 pertactin (P.69 Prn), filamentous hemagglutinin (FHA), pertussis toxin (Ptx), and combined fimbria type 2 and 3 antigens (Fim2/3) and to diphtheria toxin (Dtx) and tetanus toxin (TT) in a single well. The mouse DTP MIA was shown to be specific and sensitive and to correlate with the six single in-house enzyme-linked immunosorbent assays (ELISAs) for all antigens. Moreover, the MIA was expanded to include avidity measurements of DTP antigens in a multivalent manner. The sensitivities of the mouse DTP avidity MIA per antigen were comparable to those of the six individual in-house avidity ELISAs, and good correlations between IgG concentrations obtained by both methods for all antigens tested were shown. The regular and avidity mouse DTP MIAs were reproducible, with good intra- and interassay coefficients of variability (CV) for all antigens. Finally, the usefulness of the assay was demonstrated in a longitudinal study of the development and avidity maturation of specific IgG antibodies in mice having received different DTP vaccines. We conclude that the hexaplex mouse DTP MIA is a specific, sensitive, and high-throughput alternative for ELISA to investigate the quantity and quality of serological responses to DTP antigens in preclinical vaccine studies.
卡罗维·发利——全世界电影的一面镜子 (1958)

第十一届卡罗维·发利国际电影节将于本月12日到27日举行。本文是卡罗维·发利国际电影节主席布洛乌希教授在去年社会主义国家电影工作者第一次创作会议上所作的发言,对我们了解目前卡罗维·发利国际电影节的意义与地位会有所帮助,我们特将此文发表于此。因篇幅关系,其中稍有删节。标题是由我们代拟的。
Essential amino acid-induced adult hyperammonemic encephalopathy and hypophosphatemia (1990)

LAMIELL, JAMES J. MD; DUCEY, JOSEPH P. MD; FREESE-KEPCZYK, BARBARA J. RD; MUSIO, FRANCO MD; HANSBERRY, KURT L. MD Author Information
A Synopsis of Skin Diseases (1960)

The author has attempted to outline subject material useful for the busy practitioner, the house staff officer, and medical student. Most of the common dermatoses are covered. As with many synopses, readability and orderly classifications suffer. The absence of illustrations and lack of current therapy may detract from its value for the student. As a synopsis it lacks continuity albeit there is a wealth of material presented.
Characterization of a Novel Monoclonal Antibody with Restricted Specificity to the Free <i>β</i> 2 Integrin <i>α</i> M CD11b Subunit (2007)

Leukocyte cell surface expression and function of beta2 integrins require the intracellular association of alpha subunits, CD11a, b, c, d, respectively, with the common CD18 beta2 subunit. We have raised and characterized a murine MAb -- ME-MDF -- directed against the low affinity form of the human integrin alphaM subunit CD11b A-domain. MAb ME-MDF is an IgG2a that has a kDa of 2,45461 +/- 0.12 x 10(-9) M. MAb ME-MDF recognizes both the low and high affinity forms of the CD11b A-domain. Flow cytometry showed that ME-MDF does not recognize the heterodimeric CD11b/CD18 molecule at the surface of polymorphonuclear cells and the human monoblast cell line U937. Western blot analysis of U937 cell line cell surface proteins demonstrated that ME-MDF reacts specifically with the CD11b subunit but does not react with the heterodimeric CD11b/CD18 complex, a feature that differentiates it from other CD11b A-dom-specific MAbs. These observations suggest that ME-MDF recognizes an epitope that is involved in the association of the two subunits and hence is not accessible within the heterodimeric form of the CD11b/CD18 molecule. These data show that the CD11b A-dom engages not only the MIDAS but also the ME-MDF-specific epitope to associate with the CD18 subunit. We have also constructed, and expressed in the yeast Pichia pastoris, the corresponding recombinant scFv form of MAb ME-MDF and characterized the CDRs. MAb ME-MDF is characterized by short VH and VL CDR3. MAb ME-MDF and/or its recombinant scFv form would be very useful to study the structural basis of the association between the alpha and beta2 integrin subunits and to investigate the possibility of modulating CR3 cell surface expression by preventing subunit association.
<i>Si</i>multaneous <i>Mu</i>ltislice <i>im</i>aging (SIMUSIM) for improved cardiac imaging (1989)

In conventional ECG gated multislice imaging of the heart, slice position and phase in the heart cycle are not independent parameters. This drawback is removed by simultaneous imaging of multiple slices. This paper describes a technique which is based on simultaneous excitation of several slices by multifrequency selective rf pulses. In comparison to conventional cardiac multislice imaging an improved quality of heart images is obtained, because more acquisitions are attributed to the MR signal of the slices. The gain in signal-to-noise ratio per measurement time increases with the square root of the number of slices investigated simultaneously. This is demonstrated using phantom experiments and cardiac images.
Rapid Directional Translocations in Virus Replication (2002)

By viewing virus development in real time, the experiments reported here reveal novel processes--rapid directional translocations--that are likely to be important elements of virus replication. Herpes simplex virus type 1 (HSV-1) was labeled by the fusion of the green fluorescent protein to a structural protein of its tegument (VP11/12), the product of gene UL46. Infection of cultured cells with this recombinant virus (GHSV-UL46) produced fluorescent particles that were distributed throughout the cytoplasm with concentrations in the perinuclear region; they were absent from the nucleus. Viewing infected cells in real time by means of video microscopy produced a novel dynamic picture of virus development. Most strikingly, some of the fluorescent particles exhibited extremely rapid directional translocations at velocities as great as 5 microm/s. The trajectories and destinations of these particles suggest that the rapid directional translocations serve at least three functions: the rapid transport of viral components to and between cytoplasmic processing stations, the delivery of materials for functions specific to the perinuclear region, and the conveyance of maturing virus particles to the plasma membrane. These rapid directional translocations are novel elements of virus assembly that are likely to be critical for efficient replication.
Adaptive saliency-based compressive sensing image reconstruction (2016)

This paper proposes an adaptive compressive sensing reconstruction method which provides a higher recovered image quality. Based on an initial compressive sampling reconstruction at a given sampling rate, the visually salient regions of the image that are more conspicuous to the human visual system are extracted using a classical graph-based method. The target acquisition subrate is further adaptively allocated among these regions, such that the new acquisition will favor the interest areas. The measurements produced by this adaptive method are fully compatible with the existing sparse reconstruction algorithms, which favors the utilization of the proposed scheme. Simulation results show that the saliency-based compressive sensing recovery method outperforms the conventional sparse reconstruction algorithms in terms of image quality at the same target sampling ratio with a smaller increment in the complexity.
NMR Spectroscopy Reveals that RNase A is Chiefly Denatured in 40% Acetic Acid: Implications for Oligomer Formation by 3D Domain Swapping (2010)

Protein self-recognition is essential in many biochemical processes and its study is of fundamental interest to understand the molecular mechanism of amyloid formation. Ribonuclease A (RNase A) is a monomeric protein that may form several oligomers by 3D domain swapping of its N-terminal alpha-helix, C-terminal beta-strand, or both. RNase A oligomerization is induced by 40% acetic acid, which has been assumed to mildly unfold the protein by detaching the terminal segments and consequently facilitating intersubunit swapping, once the acetic acid is removed by lyophilization and the protein is redissolved in a benign buffer. Using UV difference, near UV circular dichroism, folding kinetics, and multidimensional heteronuclear NMR spectroscopy, the conformation of RNase A in 40% acetic acid and in 8 M urea has been characterized. These studies demonstrate that RNase A is chiefly unfolded in 40% acetic acid; it partially retains the native helices, whereas the beta-sheet is fully denatured and all X-Pro peptide bonds are predominantly in the trans conformation. Refolding occurs via an intermediate, I(N), with non-native X-Pro peptide bonds. I(N) is known to be populated during RNase A refolding following denaturation in concentrated solutions of urea or guanidinium chloride, and we find that urea- or GdmCl-denatured RNase A can oligomerize during refolding. By revealing the importance of a chiefly denaturated state and a refolding intermediate with non-native X-Pro peptide bonds, these findings revise the model for RNase A oligomerization via 3D domain swapping and have general implications for amyloid formation.
Calibration of SWMM for Two Sydney Urban Catchments (1989)

The computer model SWMM is calibrated to model the hydrologic, hydraulic and pollutant build-up and transport processes involved in urban stormwater pollution generation and movement. The urban stormwater pollution sources discussed in this paper are; street litter, atmospheric fall-out and rain wash-out. The program SWMM is calibrated using collected data from two urban catchments in Sydney's western suburbs.
Binarsity: a penalization for one-hot encoded features (2019)

International audience
Static electrification testing of Texas Utilities 345-20.9 kV, 650 MVA generator step-up transformer under controlled factory conditions (1995)

Comanche Peak Nuclear Power Plant, with two 1150 Megawatt units, has two 345-20.9 kV, three-phase, 650 MVA transformers connected in parallel. The transformers have had a long history of hydrogen generation, and one of the Unit No. 2 transformers failed in 1983 while energized from the system for plant construction power. The failed unit was repaired and returned to Comanche Peak, and there was no evidence of static electrification involvement in the failure. During the time from installation to commercial operation in 1990 for Unit No. 1 and 1992 for Unit No. 2, the transformers were backfed from the system as needed to provide construction power. There was little regard paid to the operation of the cooling systems other than assuring the cooling was running. The transformers on unit No. 1 were subjected to several unusual electrical events - ferroresonance in 1981 and over excitation in 1983, with the generation of gasses of great concern. The decision was made to install a new transformer and return the old unit to the factory for diagnostic testing to determine the cause for the generation of combustible gas, primarily hydrogen. The dielectric integrity of the transformer could be quantified and decisions made concerningmore » the replacement of the remaining transformers. After testing, the transformer was disassembled for forensic evaluation and rebuilt for return as a spare or to replace another transformer while undergoing repairs. Deformation of the bottom of the tank was discovered with large dents in the bottom protruding inward approximately one and one-half inches. With the concern of decreased clearances or displaced flux shields in the tank, an inspection opening was cut in the end of the transformer near the bottom. While investigating the deformation, evidence of partial discharge activity was discovered at the bottom of the high-to-low insulation; a location where static electrification damage has been observed in other large shell-form transformers.« less
Software Solutions for Engineers and Scientists (2007)

Software requirements for engineering and scientific applications are almost always computational and possess an advanced mathematical component. However, an application that calls for calculating a statistical function, or performs basic differentiation of integration, cannot be easily developed in C++ or most programming languages. In such a case, the engineer or scientist must assume the role of software developer. And even though scientists who take on the role as programmer can sometimes be the originators of major software products, they often waste valuable time developing algorithms that lead to untested and unreliable routines. Software Solutions for Engineers and Scientists addresses the ever present demand for professionals to develop their own software by supplying them with a toolkit and problem-solving resource for developing computational applications. The authors' provide shortcuts to avoid complications, bearing in mind the technical and mathematical ability of their audience.The first section introduces the basic concepts of number systems, storage of numerical data, and machine arithmetic. Chapters on the Intel math unit architecture, data conversions, and the details of math unit programming establish a framework for developing routines in engineering and scientific code. The second part, entitled Application Development, covers the implementation of a C++ program and flowcharting. A tutorial on Windows programming supplies skills that allow readers to create professional quality programs. The section on project engineering examines the software engineering field, describing its common qualities, principles, and paradigms. This is followed by a discussion on the description and specification of software projects, including object-oriented approaches to software development. With the introduction of this volume, professionals can now design effective applications that meet their own field-specific requirements using modern tools and technology.
Traffic Signals Generation with Bicolor LEDS using PIC 18F Series Microcontroller (2011)

PIC 18F series microcontroller is used for control of signals to a specific time using port lines. In this contest we choose the Bicolor LEDs with Red and Green. The colors of the signals are illuminated by programming in the microcontroller. The aim of this paper is to generate three colors on a single traffic light instead of using three different color traffic signal lights. The purpose of this design is to reduce the manufacture cost of the signal lights and to use a minimum number of ports in a microcontroller and cable lines to transmit the signals to the light source. This paper describes a new design for the traffic signals.