gebhart/patrepeval huggingface dataset:
Circuital modelling for electroporation (2017)

The application of intense, short-duration pulsed electric fields to biological membranes induces an increase of their conductivity to external molecules, an effect termed electroporation (EP), which is currently exploited in several biomedical, industrial and environmental applications. The study of interaction mechanisms between pulsed electric fields and biological structures is addressed by experiments and modelling. In the latter case, analytical, circuital, numerical and molecular dynamics approaches have been proposed in the literature, providing complementary information on the EP phenomenon. In this paper, an overview on circuital modelling of EP is presented. In spite of the simplifications adopted from both a physical and electrical point of view, this approach is useful to perform rapid analysis on broad ranges of electrical parameters and provides aid to the optimization of the experimental design.
Fabrication of CMUT Cells with Gold Center Mass for Higher Output Pressure (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Hyo‐Seon Yoon, Min‐Chieh Ho, Nikhil Apte, Paul Cristman, Srikant Vaithilingam, Mario Kupnik, Kim Butts‐Pauly, Butrus T. Khuri‐Yakub; Fabrication of CMUT Cells with Gold Center Mass for Higher Output Pressure. AIP Conference Proceedings 12 September 2011; 1359 (1): 183–188. https://doi.org/10.1063/1.3607902 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
High Mobility LPE HgCdTe By Post Growth Indium Doping (1989)

N-type, 5LPE2 HgCdTe, with carrier concentrations of 2 x 10 14 cm-3 and mobilites greater than 1 x 10 5 cm /V-s, at 20 K, were produced by a Hg-vapor anneal of the as-grown, p-type starting material, followed by diffusion of an evaporated indium layer. When the Hg-vapor anneal follows the indium diffusion, the material remains p-type, indicating that the two steps are not commutative. Experimental techniques used to explore these differences were Hall effect, capacitance-voltage measurements on MIS structures, photoconductive lifetime, and SIMS. Possible causes of the differences in electrical properties between the two cases are discussed. The low temperature mobilities obtained for the n-type LPE layers compare well with bulk data from other workers. A calculation of the transport properties for the n-type case is also presented to show the effects of compensation.
Development and preliminary analysis of sensor signal database of continuous daily living activity over the long term (2014)

A new corpus of daily living activities using wearable sensors and a living activity recognition method based on sensor signals are presented. The corpus consists of both indoor and outdoor living activities measured by a small camera and a smartphone over 72 continuous hours. We collected sound and image data from the camera and motion signals from the smart phone. We then analyzed the sensor signals and performed experiments on living activity recognition using a Gaussian mixture model based on the sensor signals. Experimental results showed that combining acoustic and motion features with weighted likelihood can improve recognition accuracy compared to utilizing acoustic features only. This demonstrates the effectiveness of integrating acoustic and motion features to recognize daily living activities.
Synthesis of 5‐phenylpyrrolo[1,2‐<i>b</i>][1,2,5]‐triazepin‐2(3<i>H</i>)‐ones (1988)

Abstract The synthesis of a series of 5‐phenylpyrrolo[1,2‐ b ][1,2,5]triazepin‐2(3 H )‐ones 1 as potential anxiolytic agents is described. Benzoylation of 1‐phthalimidopyrrole, followed by hydrolysis, gave the 1‐amino‐2‐benzoylpyrroles 3 . These were further functionalized to give the penultimate 1‐aminoacetamido‐2‐benzoylpyrroles 8 and 9 , which were cyclized to the target pyrrolotriazepines 1.
Rheological behavior of a semirigid liquid crystal polymer (1993)

Abstract The rheological behavior of liquid crystal polymers is still far from completely clarified from both experimental and theoretical points of view. In this paper, the shear flow and the non‐isothermal elongation flow behavior of a semirigid liquid crystal copolyester is discussed. The viscosity strongly decreases when the test temperature is increased above the crystal‐nematic transition temperature; below this temperature the viscosity is very high. The thermal history strongly affects the shear viscosity. The elongational flow behavior depends also on temperature. Above the crystal‐nematic transition temperature and the mesophase is easily spinnable, whereas below this temperature, the spinnability is very poor.
Power Electronics for Distributed Energy Systems and Transmission and Distribution Applications: Assessing the Technical Needs for Utility Applications (2005)

Power electronics can provide utilities the ability to more effectively deliver power to their customers while providing increased reliability to the bulk power system. In general, power electronics is the process of using semiconductor switching devices to control and convert electrical power flow from one form to another to meet a specific need. These conversion techniques have revolutionized modern life by streamlining manufacturing processes, increasing product efficiencies, and increasing the quality of life by enhancing many modern conveniences such as computers, and they can help to improve the delivery of reliable power from utilities. This report summarizes the technical challenges associated with utilizing power electronics devices across the entire spectrum from applications to manufacturing and materials development, and it provides recommendations for research and development (R&D) needs for power electronics systems in which the U.S. Department of Energy (DOE) could make a substantial impact toward improving the reliability of the bulk power system.
High resolution mini-gammacamera and 99mTc [HMPAO] - leukocytes for diagnosis of infection and radioguided surgery in diabetic foot. (2006)

Discovery of osteitis may be delayed because of late appearance of X-ray signs in patients with diabetic foot. Scintigraphy with labelled leukocytes is able to detect flogosis but often misses bone involvement, due to inadequate resolution of Anger camera, the commonest detector used in nuclear medicine. Radioguided surgery and biopsy with high resolution scintigraphy (HRS) started to be studied since 2000: although this method had never been tested for planning and guiding diabetic foot surgery, in our opinion it can help early diagnosis and surgical treatment of diabetic foot. Five patients with diabetic foot and suspected infection were studied with standard 99mTc [HMPAO]-leukocyte scan. In the same patients 2 mm spatial resolution HRS was performed 24 hours after administration of labelled WBC, using our inch2 field-of-view portable mini-gammacamera. Operations were done just after the 24h scan and were guided with the portable high resolution device in the four patients who showed positive scan. Scintigraphy with Anger camera and HRS were positive in four patients. HRS showed a bar-shaped radioactivity corresponding to small phalanges, close to the main inter-digital hot spot. The presence of osteitis on phalanges that had been shown by HRS was confirmed at surgery, that was successfully driven with the high resolution mini-camera. In conclusion HRS is able to diagnose early osteitis of diabetic foot and to guide diabetic foot surgery.
Costimulation through 4-1BB/CD137 improves the expansion and function of CD8+ melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy (66.21) (2011)

Abstract Adoptive T-cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) is a powerful therapy for Stage IV melanoma patients who have failed first and second line therapies. TIL for adoptive transfer are expanded from melanoma surgical specimens with IL-2 followed by a “rapid expansion protocol” (REP), where the cells are activated with anti-CD3 antibody, PBMC feeder cells and IL-2 for two weeks, generating a final infusion product. The REP yields billions of highly-differentiated cytolytic CD8+ T cells that lose costimulatory molecules CD28 and CD27, and are hyporesponsive to further proliferative signals. We found “post-REP” CD8+ TIL express an alternative costimulatory molecule of the TNF-R family, 4-1BB. Our study tests the effects of an agonistic anti-4-1BB antibody added at the time of initiating the REP. We found adding an agonistic anti-4-1BB antibody increased CD8+ T-cell recovery, antigen specificity, BCL-2 gene expression and increased the frequency of CD28+ cells in the recovered CD8+ post-REP TIL. Adding anti-4-1BB improved post-REP TIL survival capacity in the absence of cytokine, with TIL continuing to divide even without added IL-2. Our findings suggest adding an agonistic anti-4-1BB antibody during the time of TIL REP initiation produces a CD8+ T cell population capable of improved effector function and survival. This may greatly improve TIL persistence and anti-tumor activity in vivo after adoptive transfer into patients.
Polarization anisotropy in the electroabsorption of ordered GaInP (1997)

The polarization dependence of the Franz–Keldysh effect (FKE) in metalorganic vapor phase epitaxially grown AlGaInP/GaInP/AlGaInP p-i-n double heterostructures was investigated for samples with different ordering parameters. We determine an ordering induced shift of the FK spectra of up to 13 meV between light polarized along the [011] and [01-1] crystal directions. Due to the FKE the transmitted light intensity ratio between the respective polarizations was changed from 0.2 to 2.8 dB by applying an electric field of 335 kV/cm.
Human neural progenitor cells retain viability, phenotype, proliferation, and lineage differentiation when labeled with a novel iron oxide nanoparticle, Molday ION Rhodamine B (2013)

Ultrasmall superparamagnetic iron-oxide particles (USPIOs) loaded into stem cells have been suggested as a way to track stem cell transplantation with magnetic resonance imaging, but the labeling, and post-labeling proliferation, viability, differentiation, and retention of USPIOs within the stem cells have yet to be determined for each type of stem cell and for each type of USPIO. Molday ION Rhodamine B™ (BioPAL, Worcester, MA, USA) (MIRB) has been shown to be a USPIO labeling agent for mesenchymal stem cells, glial progenitor cells, and stem cell lines. In this study, we have evaluated MIRB labeling in human neuroprogenitor cells and found that human neuroprogenitor cells are effectively labeled with MIRB without use of transfection reagents. Viability, proliferation, and differentiation properties are unchanged between MIRB-labeled neuroprogenitors cells and unlabeled cells. Moreover, MIRB-labeled human neuroprogenitor cells can be frozen, thawed, and replated without loss of MIRB or even without loss of their intrinsic biology. Overall, those results show that MIRB has advantageous properties that can be used for cell-based therapy.
Characterization of Wireless Smart Sensor Performance (2010)

A critical aspect of using wireless sensors for structural health monitoring is communication performance. Unlike wired systems, data transfer is less reliable between wireless sensor nodes owing to data loss. While reliable communication protocols are typically used to reduce data loss, this increase in communication can drain already limited power resources. This paper provides an experimental investigation of the wireless communication characteristics of the Imote2 smart sensor platform; the presentation is tailored toward the end user, e.g., application engineers and researchers. Following a qualitative discussion of wireless communication and packet delivery, a quantitative characterization of wireless communication capabilities of the Imote2 platform, including an assessment of onboard and external antenna performance, is provided. Herein, the external antenna was found to significantly outperform the onboard antenna in both transmission and reception reliability. However, the built environment, including building materials and other wireless networks, can significantly reduce reception rate and thus increase packet loss. Finally, implications of these results for a full-scale implementation are presented.
The role of MHC class II molecules in susceptibility and resistance to autoimmunity (1998)

The mechanism by which particular MHC class II alleles mediate susceptibility to a given autoimmune disease is unknown. During the past year, reports have indicated that the effects of MHC class II alleles which protect against type I diabetes in the nonobese diabetic mouse strain may, in some cases, be due to negative selection of diabetogenic T cell receptors and, in other cases, to positive selection of other T cells with a suppressive action on the diabetic process. Progress towards understanding the mechanisms of susceptibility continues to lag.
Fabrication of a 40 MHz Single Element Ultrasonic Transducer Using a PMN-PT Single Crystal (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Increased Burden of Vision Impairment and Eye Diseases in Persons with Chronic Kidney Disease — A Population-Based Study (2016)

The burden of VI and eye diseases is high among persons with CKD. Our findings suggest that it may be useful to screen for ocular disease and VI in persons with CKD.
Precise Quantitative Assessment of the Clinical Performances of Two High‐Flux Polysulfone Hemodialyzers in Hemodialysis: Validation of a Blood‐Based Simple Kinetic Model Versus Direct Dialysis Quantification (2017)

Highly permeable dialysis membranes with better design filters have contributed to improved solute removal and dialysis efficacy. However, solute membrane permeability needs to be well controlled to avoid increased loss of albumin that is considered to be detrimental for dialysis patients. A novel high-flux dialyzer type (FX CorDiax; Fresenius Medical Care) incorporating an advanced polysulfone membrane modified with nano-controlled spinning technology to enhance the elimination of a broader spectrum of uremic toxins has been released. The aim of this study was to compare in the clinical setting two dialyzer types having the same surface area, the current (FX dialyzer) and the new dialyzer generation (FX CorDiax), with respect to solute removal capacity over a broad spectrum of markers, including assessment of albumin loss based on a direct dialysis quantification method. We performed a crossover study following an A1-B-A2 design involving 10 patients. Phase A1 was 1 week of thrice-weekly bicarbonate hemodialysis with the FX dialyzer, 4 h per treatment; phase B was performed with a similar treatment regimen but with a new FX CorDiax dialyzer and finally the phase A2 was repeated with FX dialyzer as the former phase. Solute removal markers of interest were assessed from blood samples taken before and after treatment and from total spent dialysate collection (direct dialysis quantification) permitting a mass transfer calculation (mg/session into total spent dialysate/ultrafiltrate). On the blood side, there were no significant differences in the solute percent reduction between FX CorDiax 80 and FX 80. On the dialysate side, no difference was observed regarding eliminated mass of different solutes including β<sub>2</sub> -microglobulin (143.1 ± 33.6 vs. 138.3 ± 41.9 mg, P = 0.8), while the solute mass removal of total protein (1.65 ± 0.51 vs. 2.14 ± 0.75 g, P = 0.04), and albumin (0.41 ± 0.21 vs. 1.22 ± 0.51 g, P < 0.001) were significantly less for FX CorDiax 80 compared to the FX 80 dialyzer. The results of this cross-over study indicate that the new FX CorDiax dialyzer has highly effective removal of middle molecules, without any concomitant increase in total protein and albumin loss. The clinical relevance and potential benefit of this finding needs to be determined.
Point mutations and deletions of the Bcl10 gene in solid tumors and malignant lymphomas. (1999)

The Bcl10 gene, which encodes a protein with proapoptotic activity, recently has been identified on chromosome 1p22. In this study, we analyzed somatic mutations and deletions of the Bcl10 gene in a series of 439 tumor tissues from various histological origins that are known to have frequent loss of heterozygosity at chromosome 1p22. According to the LOH study at intragenic polymorphic sites, deletion of Bcl10 in informative cases was detected in 50% of malignant mesotheliomas, 33% of gastric carcinomas, 23% of breast carcinomas, 20% of hepatocellular carcinomas, 17% of lymphomas, 15% of colorectal carcinomas, 13% of laryngeal carcinomas, and 10% of male germ cell tumors (GCTs). In contrast, we detected Bcl10 mutations in 4 of 120 lymphomas (3.3%) and 2 of 78 GCTs (2.6%), respectively, but no mutation was found in the remaining solid tumors analyzed. Taken together, these data imply that Bcl10 may occasionally be involved in the pathogenesis of lymphoma and GCTs. However, the absence or low frequency of the mutation suggests that either Bcl10 is inactivated by other mechanisms or it is not the only target of chromosome 1p22 deletion in human tumors.
Examine the position in world affairs today of any Commonwealth country, indicating the particular responsibilities and opportunities which accrue from being a part of the Commonwealth. (1960)

Essay entered under category A; winner of 2nd prize
Automated high-throughput registration for localizing 3D mouse brain gene expression using ITK (2005)

The Allen Brain Atlas (ABA) project aims to create a cellular-resolution, genome-wide map of gene expression in the adult mouse brain. The resulting in situ hybridization (ISH) image data will be available free-of-charge to the public. Additionally, we are developing an informatics pipeline to support searching of the data by anatomic region and expression level and/or pattern. This paper describes a robust, high-throughput registration scheme to automatically annotate hierarchical brain structures in the ISH imagery.
Surface-emitting laser-based smart pixels for two-dimensional optical logic and reconfigurable optical interconnections (1993)

A monolithic smart pixel technology based on the integration of two-dimensional arrays of cascadable optical switches, optical logic gates, and optical switching nodes consisting of vertical-cavity surface-emitting lasers and heterojunction phototransistors or photothyristors is described. Different combinations of these components perform optical switching, logic, routing, memory, and regeneration. Latching, nonlatching, and bistable switches with high optical gain and contrast are demonstrated, along with all the simple single-stage Boolean optical logic functions. A 2*2 optical bypass-exchange node and a reconfigurable, multistage, two-dimensional optical switching network architecture are also described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Quantum Fluctuations of the Refractive Index near the Interface Between a Metal and a Nonlinear Dielectric (2005)

Zero-point fluctuations of surface plasmon modes near the interface between a metal and a nonlinear dielectric are shown to produce a thin layer of shifted fluctuating dielectric constant near the interface. The shift of the dielectric constant in this layer may be sufficiently large to produce multiple metastable states of the surface plasmon vacuum.
Tetragonal and Cubic Zirconia Multilayered Ceramic Constructs Created by EPD (2012)

The interest in electrophoretic deposition (EPD) for nanomaterials and ceramics production has widely increased due to the versatility of this technique to effectively combine different materials in unique shapes and structures. We successfully established an EPD layering process with submicrometer sized powders of Y-TZP with different mol percentages of yttrium oxide (3 and 8%) and produced multilayers of alternating tetragonal and cubic phases with a clearly defined interface. The rationale behind the design of these multilayer constructs was to optimize the properties of the final ceramic by combining the high mechanical toughness of the tetragonal phase of zirconia together with the high ionic conductivity of its cubic phase. In this work, a preliminary study of the mechanical properties of these constructs proved the good mechanical integrity of the multilayered constructs obtained as well as crack deflection in the interface between tetragonal and cubic zirconia layers.
Interactions between the Oocyte and Cumulus Cells in the Ovary of the B6.YTIR Sex-Reversed Female Mouse1 (1997)

The XY (B6.Y(TIR)) sex-reversed female mouse is infertile, primarily because of the early death of its embryos. We have previously determined that the XY oocyte itself, not the surrounding somatic cells, is responsible for its failure in postfertilization development. In the present study, we assessed the ability of the XY oocyte to regulate granulosa cell differentiation and functions. Oocyte-cumulus complexes (OCC) were isolated from antral follicles and were cultured in the presence of FSH and testosterone. Microsurgical removal of oocytes prevented cumulus cell expansion and suppressed estradiol production while it promoted progesterone production. Coculture with denuded oocytes from either XX or XY ovaries restored cumulus expansion and the endocrine profile observed in intact OCC. Morphology of oocytes and OCC in the preantral and antral follicles in situ as well as after isolation was compared for XX and XY ovaries. The average area of XY oocytes was smaller by 20% only at the preantral stage, whereas the zona pellucida layer was thinner by 20% at all stages. Furthermore, the XY oocyte was found to be attached to fewer cumulus cells (60% of XX control) in antral follicles and isolated OCC. In conclusion, the XY oocyte develops the normal ability of regulating granulosa cell differentiation despite its inferiority with respect to some morphometric parameters when compared to the XX oocyte.
Preclinical models: Needed in translation? A Pro/Con debate (2014)

The discovery of the causative mutations and many of the predisposing risk factors for neurodegenerative disorders such as Amyotrophic Lateral Sclerosis, Alzheimer's, Parkinson's, and Huntington's disease (HD), has led to the development of a large number of genetic animal models of disease. In the case of HD, for example, over 20 different transgenic rodent models have been generated. These models have been of immense value in providing novel insights into mechanisms of disease, with the promise of accelerating the development of therapies that can delay the onset or slow the progression of the disease. Yet, despite extensive use of such models, no effective treatment for HD has been developed. Here, we discuss the value of animal models, highlighting their strengths and shortcomings in the context of translational research for HD.