gebhart/patrepeval huggingface dataset:
Variations in Radioresistance of Rats during the Period of Growth (1968)

SummaryLD50(30) values were estimated in about 7000 Wistar rats of various ages from the late foetal period up to 10 months old. The rats were exposed to bilateral 200 kv whole-body x-irradiation. The dose variations throughout the whole volume of the animals did not exceed ±4 per cent. The tissue dose in rads was determined by special measurements.The LD50 values demonstrated an increasing radioresistance in foetuses from the age of gestation day 17 to one day before birth. Immediately after birth the radioresistance was less than one day before. Increasing radio-resistance was seen again during the first part of the suckling period and after weaning. During the second part of the suckling period no change or radio-resistance occurred.
Automated IT Audit of Windows Server Access Control (2019)

To protect sensitive information of an organization, we need to have proper access controls since several data breach incidents were happened because of broken access controls. Normally, the IT auditing process would be used to identify security weaknesses and should be able to detect any potential access control violations in advance. However, most auditing processes are done manually and not performed consistently since lots of resources are required; thus, the auditing is performed for quality assurance purposes only. This paper proposes an automated process to audit the access controls on the Windows server operating system. We define the audit checklist and use the controls defined in ISO/IEC 27002:2013 as a guideline for identifying audit objectives. In addition, an automated audit tool is developed for checking security controls against defined security policies. The results of auditing are the list of automatically generated passed and failed policies. If the auditing is done consistently and automatically, the intrusion incidents could be detected earlier and essential damages could be prevented. Eventually, it would help increase the reliability of the system.
You Can't Fire Me: The Problems with Wrongful Dismissal Damages in Canada (2017)

The assessment of wrongful dismissal damages in Canadian law has long been governed by the principles established in Bardal v Globe & Mail Ltd. Although this model of analysis has been met with near universal approval in every decision-making forum in Canada, the principles underlying Bardal warrant further discussion. This work focuses on the contractual core of employment disputes and analyzes the interpretive framework for common law claims for wrongful dismissal. It will show that the traditional law of private remedies has been distorted in the context of wrongful dismissal as a result of the wholesale adoption of the Bardal Factors. The Bardal approach requires courts to depart from traditional doctrines of remedies and contract law and extends beyond the traditional goal of restitutio in integrum to a distributive theory of damages. This ultimately results in outcomes that depart from the original goal of wrongful dismissal remedies: protecting societyâs vulnerable workers from unfair employment practices. This paper will suggest that damages from the breach of the employment contract should be objectively assessed from the intention of the parties at the time of contract formation. The courts in Lazarowicz and Bartlam have provided useful guidance with respect to how this method can be successfully applied. Returning to the goal of restitutio in integrum and corrective justice in wrongful dismissal damages would provide needed predictability and stability in employment relationships.
Quadratic filters for signal processing (1992)

Polynomial (or Volterra) filters are introduced, and the quadratic filters are presented as the simplest example of such filters. The principle aspects and properties of quadratic filters are derived in the framework of the discrete Volterra expansion. Fixed as well as adaptive filters are considered in one-dimensional and multidimensional environments. Such issues as design and efficient realizations are thoroughly addressed, and standard and advanced adaptation algorithms are presented. Several examples of signal processing applications requiring quadratic filters are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity (2018)

The transcription factor PLZF (promyelocytic leukemia zinc finger protein) acts as an epigenetic regulator balancing self-renewal and differentiation of hematopoietic cells through binding to various chromatin-modifying factors. First described as a transcriptional repressor, PLZF is also associated with active transcription, although the molecular bases underlying the differences are unknown. Here, we reveal that in a hematopoietic cell line, PLZF is predominantly associated with transcribed genes. Additionally, we identify a new association between PLZF and the histone methyltransferase, EZH2 at the genomic level. We find that co-occupancy of PLZF and EZH2 on chromatin at PLZF target genes is not associated with SUZ12 or trimethylated lysine 27 of histone H3 (H3K27me3) but with the active histone mark H3K4me3 and active transcription. Removal of EZH2 leads to an increase of PLZF binding and increased gene expression. Our results suggest a new role of EZH2 in restricting PLZF positive transcriptional activity independently of its canonical PRC2 activity.
Metabolic Energy Requirements for Space Flight (1994)

The international space community, including the USSR, Japan, Germany, the European Space Agency, and the US, is preparing for extended stays in space. Much of the research planned for space will be tended by humans, thus, maintaining adequate nutritional status during long stays in space has lately become an issue of much interest. Historically, it appears that minimum nutritional requirements are being met during stays in space. Thus far, crewmembers have been able to consume food adequate for maintaining nominal performance in microgravity. The physiological data obtained from ground-based and flight research that may enable us to understand the biochemical alterations that effect energy utilization and performance. Focus is on energy utilization during the Apollo lunar missions, Skylab's extended space lab missions, and Space Shuttle flights. Available data includes those recorded during intra- and extravehicular activities as well as during microgravity simulation (bed rest). Data on metabolism during flight and during bed rest are discussed, with a follow-up on human gastrointestinal function.
Self-load bank for UPS testing by circulating current method (1994)

For saving energy and reducing costs of the burn-in testing of an uninterruptible power supply (UPS) system, a self-load bank using the circulating method is proposed. The AC/DC power converter of the tested UPS itself is used as a nonlinear load, the tested current flow as a form of circulation, and the power of the tested load is controlled by a DC regulator also supplying the energy loss of the tested UPS. To test a linear load, a regulator is used to regulate the load characteristic. From the experimental results the energy saved in the burn-in test is approximately 80% of that lost by the conventional method, using a directly connected RLC or rectifier load.
Pressure while Drilling Data Improves Reservoir Drilling Performance (1997)

Abstract A new down-hole annular Pressure-While-Drilling (PWD) tool has recently been applied to assist drilling of the reservoir section on the Statfjord Field, offshore Norway. In these highangle wells it is critical for drilling success to maintain the mud weight and Equivalent Circulating Density (ECD) within safe operating limits defined by the formation fluid, collapse, and fracture pressures. Operating outside these limits has historically led to expensive lost circulation, differential sticking, and pack-off incidents. Monitoring the actual down-hole pressure in real-time with a PWD tool, rather than relying on inferred pressures from predictive models, has allowed the Operator to stay within and better define these operating limits. The Operator used this improved hydraulics information to avoid pressure-related hole problems, optimise drilling practices, test hydraulics models, and obtain a greater understanding of the formation pressure limits.
Levels of small molecules in dormant spores of <i>Sporosarcina</i> species and comparison with levels in spores of <i>Bacillus</i> and <i>Clostridium</i> species (1993)

Dormant spores of Sporosarcina halophila and Sporosarcina ureae contained no detectable ATP, significant levels of ADP, even higher levels of AMP, and a large pool of 3-phosphoglyceric acid, similar to what is found in dormant spores of Bacillus and Clostridium species. Sporosarcina halophila and S. ureae spores also contained significant pools of free amino acids, in particular glutamic acid, as in the case with spores of Bacillus but not Clostridium species. Levels of monovalent and divalent inorganic cations were comparable in spores of Sporosarcina, Clostridium, and Bacillus species, and cation levels in spores of the slight halophile S. halophila were similar to those in S. ureae spores. These data suggest that levels of small molecules are generally similar in spores of all Gram-positive organisms, and further suggest that these levels reflect fundamental and conserved features of the sporulation process and dormant spores in these organisms. The data are also consistent with the proposed close evolutionary relationship between Bacillus and Sporosarcina species.
Low doses of neonicotinoid pesticides in food rewards impair short-term olfactory memory in foraging-age honeybees (2015)

Neonicotinoids are often applied as systemic seed treatments to crops and have reported negative impact on pollinators when they appear in floral nectar and pollen. Recently, we found that bees in a two-choice assay prefer to consume solutions containing field-relevant doses of the neonicotinoid pesticides, imidacloprid (IMD) and thiamethoxam (TMX), to sucrose alone. This suggests that neonicotinoids enhance the rewarding properties of sucrose and that low, acute doses could improve learning and memory in bees. To test this, we trained foraging-age honeybees to learn to associate floral scent with a reward containing nectar-relevant concentrations of IMD and TMX and tested their short (STM) and long-term (LTM) olfactory memories. Contrary to our predictions, we found that none of the solutions enhanced the rate of olfactory learning and some of them impaired it. In particular, the effect of 10 nM IMD was observed by the second conditioning trial and persisted 24 h later. In most other groups, exposure to IMD and TMX affected STM but not LTM. Our data show that negative impacts of low doses of IMD and TMX do not require long-term exposure and suggest that impacts of neonicotinoids on olfaction are greater than their effects on rewarding memories.
Fault diagnosis in automotive alternators based on the output voltage parameters (2019)

Based on analytical studies, it has been established that for automotive alternators the amplitude of the output voltage ripple can be considered a diagnostic parameter indicative of the occurrence of faults leading to its failure. Changing structural parameters in the course of physical modeling provided a way to establish thresholds for the occurrence and development of the most common electrical faults in automotive alternators. Results of experimental research confirm the relationship between structural and diagnostic parameters that was established analytically. Analysis of the obtained data suggests that it is possible to diagnose a fault, which in near future will lead to failure of the automotive alternator, in advance, based on the output voltage parameters.
Palindromic sequences preceding the terminator increase polymerase III template activity (1997)

Four consecutive T residues in the sense strand are sufficient to terminate transcription by RNA polymerase III (pol III). Previously we observed that compared with this minimally sufficient terminator, five T residues immediately preceded by a palindromic sequence increases transcriptional expression both in vitro and in vivo, raising the question of whether a palindromic sequence has a role in pol III termination. Here we observe that site-directed mutations which eliminate the dyad symmetry of the palindromic sequence decrease transcriptional expression. Similar effects are observed whether dyad symmetry is eliminated in regions of the palindrome which are proximal or distal with respect to the terminator. Compensatory mutations at either site to restore dyad symmetry rescue transcriptional activity. These observations suggest that a higher order structure, such as a RNA hairpin, immediately preceding the terminator increases pol III transcriptional activity.
An approach to control the tip shapes and properties of ZnO nanorods (2005)

High-density, well aligned, -oriented wurtzite ZnO nanorod arrays with significantly different tip shapes were controllably fabricated by evaporating zinc powders at temperatures varying from 450 to 600 °C. It is found that the tip shape depends not only on the substrate but also on the substrate direction relative to the auxiliary gas flow, and the radius of curvature at these tips can be less than 2 nm. These nanorods exhibit good rectification characteristics in conductive atomic force microscopy (CAFM) measurements; the current rectification can be as large as ∼103 at 1 V. The conductance of these 'nanotips' can be tuned readily by simple air-annealing.
Microstructurally Developed Toughening Mechanisms in Ceramics--Transformation Toughening in the A1 sub 2 O sub 3/ZrO sub 2 Composite System. (1979)

Three A1203/ZrO2 composites series, containing 0, 2, and 7.5 mole % Y203, respectively, were fabricated. For the A1203/ZrO2(+2M/oY203) series, tetragonal ZrO2 was retained from one end-member to the other. Significant increases in fracture toughness and strength were observed for materials in this system. Strengths decreased with increasing temperature. These results are consistent with previous theoretical predictions. (Author)
Photophysical Studies and <i>In Vitro</i> Skin Permeation/Retention of Foscan<sup>®</sup>/Nanoemulsion (NE) Applicable to Photodynamic Therapy Skin Cancer Treatment (2008)

In this work we evaluated the photophysical and in vitro properties of Foscan, a second-generation photosensitizer drug (PS) widely used in systemic clinical protocols for cancer therapy based on Photodynamic Therapy (PDT). We employed biodegradable nanoemulsions (NE) as a colloidal vehicle of the oil/water (o/w) type focusing in topical administration of Foscan and other photosensitizer drugs. This formulation was obtained and stabilized by the methodology described by Tabosa do Egito et al., based on the mixture of two phases: an aqueous solution and an organic medium consisting of nonionic surfactants and oil. The photodynamic potential of the drug incorporated into the NE was studied by steady-state and time-resolved spectroscopic techniques. We also analyzed the in vitro biological behavior carried out in mimetic biological environment protocols based on the animal model. After topical application in a skin animal model, we evaluated the Foscan/NE diffusion flux into the skin layers (stratum corneum and epidermis + dermis) by classical procedures using Franz Diffusion cells. Our results showed that the photophysical properties of PS were maintained after its incorporation into the NE when compared with homogeneous organic medium. The in vitro assays enabled the determination of an adequate profile for the interaction of this system in the different skin layers, with an ideal time lag of 6 h after topical administration in the skin model. The Foscan diffusion flux (J) was increased when this PS was incorporated into the NE, if compared with its flux in physiological medium. These parameters demonstrated that the NE can be potentially applied as a drug delivery system (DDS) for Foscan in both in vitro and in vivo assays, as well as in future clinical applications involving topical skin cancer PDT.
The Matching Network of the Inductively Coupled Discharge Lamps. (1995)

Inductively coupled electrode-less discharge lamps have been developed as new light sources. To operate these lamps, matching networks are used for stabilizing the plasma. However, the design theory of the matching networks for these lamps has not been clearly known. The difficulty comes from the non-linearity of the plasma impedance. In this paper, the matching networks for the inductively coupled electrode-less discharge lamps are theoretically analyzed by means of an equivalent circuit model consisting of the two inductors connected in parallel and in series to the plasma resistance. First, the author took measurement of the input impedance of the electrode-less fluorescent lamp circuit, and confirmed the validity of the equivalent circuit model. Using this model, he analyzed the matching network, and found that an impedance-inverter circuit consists of the matching network and the coil is most preferable for starting and stabilizing the plasma. In this circuit, the plasma current lp is limited by the formula, /lp/<ne/B/, where n is the constant defined by the coil structure, e is electromotive force of the power source, and B is the parameter determined by the circuit. The author also calculated the circuit parameters in the case of a 5-ladder circuit.
Greenstein (Fred I). — Children and politics. [Les enfants et la politique]. (1968)

Vincent Gabriel. Greenstein (Fred I). — Children and politics. [Les enfants et la politique].. In: Revue française de pédagogie, volume 2, 1968. pp. 76-77.
The capabilities and limitations of conductance-based compartmental neuron models with reduced branched or unbranched morphologies and active dendrites (2010)

Conductance-based neuron models are frequently employed to study the dynamics of biological neural networks. For speed and ease of use, these models are often reduced in morphological complexity. Simplified dendritic branching structures may process inputs differently than full branching structures, however, and could thereby fail to reproduce important aspects of biological neural processing. It is not yet well understood which processing capabilities require detailed branching structures. Therefore, we analyzed the processing capabilities of full or partially branched reduced models. These models were created by collapsing the dendritic tree of a full morphological model of a globus pallidus (GP) neuron while preserving its total surface area and electrotonic length, as well as its passive and active parameters. Dendritic trees were either collapsed into single cables (unbranched models) or the full complement of branch points was preserved (branched models). Both reduction strategies allowed us to compare dynamics between all models using the same channel density settings. Full model responses to somatic inputs were generally preserved by both types of reduced model while dendritic input responses could be more closely preserved by branched than unbranched reduced models. However, features strongly influenced by local dendritic input resistance, such as active dendritic sodium spike generation and propagation, could not be accurately reproduced by any reduced model. Based on our analyses, we suggest that there are intrinsic differences in processing capabilities between unbranched and branched models. We also indicate suitable applications for different levels of reduction, including fast searches of full model parameter space.
Preparation of some derivatives of benzo[ij]quinolizine (1985)

Reaction of 1,2,3,4-tetrahydroquinoline with 1-chloro-2,3-epoxypropane afforded l-(3-chloro-2-hydroxypropyl)-l,2,3,4-tetrahydroquinoline ( IIb ) which was thermolabile and on heating in vacuo was converted into 2,3,6,7-tetrahydro-1 H ,5 H -benzo[ ij ]quinolizin-2-ol ( Ib ). This compound reacted with acetic anhydride and p -toluenesulfonyl chloride to give 2-acetoxy-2,3,6,7-tetrahydro-1 H ,5 H -benzo[ ij ]quinolizine ( Ic ) and 2-( p -toluenesulfonyloxy)-2,3,6,7-tetrahydro-1 H ,5 H -benzo[ ij ]quinolizine ( Id ), respectively. N,N-Bis(3-chloro-2-hydroxypropyl)aniline ( IIIb ) on heating gave a mixture of cis - and trans -2,3,6,7-tetrahydro-1 H ,5 H -benzo[ ij ]quinolizine-2,6-diols ( Ie ). The corresponding 4-methoxyaniline derivative afforded analogously a mixture of cis - and trans -9-methoxy-2,3,6,7-tetrahydro-1 H ,5 H -benzo[ ij ]quinolizine-2,6-diols ( If ). Dehydration with potassium hydroxide converted the diols Ie into 1 H ,7 H -benzo[ ij ]quinolizine ( VIa ), the diols If into 9-methoxy-1 H ,7 H -benzo[ ij ]quinolizine ( VIb ). Treatment of Ib with phosphorus pentoxide led to 2,3,6,7-tetrahydro-1 H ,5 H -benzo[ ij ]quinolizine (julolidine, Ia ).
La grotte sépulcrale de Vichel-Nanteuil (Aisne)et l'habitat de la civilisation ''Seine - Oise -Marne" dans le bassin moyen de l'Ourcq (1975)

Parent René. La grotte sépulcrale de Vichel-Nanteuil (Aisne)et l'habitat de la civilisation ''Seine - Oise -Marne" dans le bassin moyen de l'Ourcq. In: Cahiers archéologiques de Picardie, n°2, fascicule 1, 1975. pp. 13-18.
Single‐dose pharmacokinetic and pharmacodynamic comparison of polymer‐ matrix (Slow Trasicor) and Oros dosage forms of oxprenolol in healthy volunteers. (1985)

Oxprenolol was administered in single doses by mouth to healthy volunteers either in a polymer-matrix slow-release formulation (Slow Trasicor) or in osmotic drug-delivery systems (oxprenolol Oros). Plasma oxprenolol concentrations and heart rates after exercise were measured. Plasma concentrations of the drug were maximal at 3 h but negligible at 24 h after administration of Slow Trasicor. Following ingestion of the Oros systems measurable concentrations were maintained throughout 24 h. Significant reduction of exercise-induced tachycardia persisted for 24 h after administration of oxprenolol Oros. With Slow Trasicor heart rate responses had returned to baseline values by this time. The osmotic drug-delivery systems appear to sustain significant beta-adrenoceptor blockade for 24 h after a single oral dose.
Evaluation of oxidative stress in diabetic patients after supplementation with a standardised red orange extract. (2002)

Diabetes mellitus is associated with a high oxidative stress level, resulting from an imbalance between free radicals or reactive oxygen species production and the antioxidant systems. Inhibition of these oxidative processes by co-adjuvant therapy could therefore prevent, or at least delay, the onset and/or the development of long-term diabetic complications. Dietary supplementation with plant biophenols may be a successful strategy to decrease this risk of pathological complications. The Red Orange Complex (ROC) is a standardized red orange extract containing, as its main active principles, phenolic compounds (anthocyanins, flavanones and hydroxycinnamic acids) as well as ascorbic acid. The aim of the present preliminary study was to evaluate the effects of short-term (2 mo) dietary supplementation with ROC (50 mg/d, orally) on some serum non-invasive biomarkers of oxidative stress (total antioxidant status, or TAS, levels of thiol groups and levels of free radicals) in a group of 33 patients with Type 2 diabetes, in comparison with a group of 28 healthy volunteers. The results obtained demonstrate that in diabetic patients supplementation with ROC can improve blood levels of thiol groups on proteins (an indirect measurement of glutathione activity in serum); furthermore, it can elicit a marked decrease in serum free radical levels, in patients with high blood oxidative stress status. However, ROC supplementation appeared unable to modify serum TAS. Finally, the glycemic profile remained stable during the study period in all subjects, and no unpleasant side effects were reported. In conclusion, the treatment of diabetic patients with ROC might be of therapeutic benefit in order to protect against diabetes complications that are partially due to uncontrolled lipid oxidation. D