gebhart/patrepeval huggingface dataset:
[Effect of (2"R)-4'-O-tetrahydropyranyladriamycin, a new antitumor antibiotic, on the cardiac function of hamsters]. (1986)

Cardiovascular effects of (2''R)-4'-O-tetrahydropylanyladriamycin X HCl (THP) and doxorubicin (adriamycin, ADM) were studied in hamsters. In experiments to observe acute effects, THP was administered intravenously at a dose of 12.5, 25.0 or 50.0 mg/kg, and ADM at 1.56, 3.13 or 6.25 mg/kg was given to different subjects. The THP caused slight ECG alterations at a dose of 12.5 mg/kg. At a dose of 25.0 mg/kg or 50.0 mg/kg, THP caused moderate to remarkable alterations in ECG like a widening of PR and PRc interval, A-V block, ST segment depression and T wave flattening. The ADM caused moderate to remarkable alterations in ECG at a dose of 3.13 mg/kg or 6.25 mg/kg, including arrhythmia, bradycardia, A-V block, ST segment changes and T wave flattening. These changes caused by THP and ADM recovered within 5 approximately 10 minutes after injection. Alterations in the ultrastructure of the myocardium caused by THP at a dose of 50.0 mg/kg included some cells with slight changes like swelling of mitochondria, focal intracellular edema, and enlargement of myofibrils. The ADM, at a dose of 3.13 mg/kg, induced severer swelling of mitochondria than THP, dilatation of sarcoplasmic reticulum, intracellular edema, and disorganization of myofilaments. At a dose of 6.25 mg/kg of ADM, these changes became more pronounced. In experiments to observe subacute effects, hamsters were treated with THP or ADM by daily intraperitoneal injections for 15 consecutive days, and then allowed to be recovered for 15 days. Dose levels of THP or ADM were 0.125, 0.25, 0.5 and 1.0 mg/kg. General toxicity, ECG, hematological and blood biochemical analysis, and electron microscopic examination were studied. In the ECG study, THP-treated hamsters showed a reversible elevation of R wave amplitude at a daily dose of 0.5 mg/kg. Widening of PR and PRc interval, elevation of R and S wave amplitude, and reduction of T wave amplitude were observed at a daily dose of 1.0 mg/kg of THP. Hamsters treated with ADM showed increase of heart rate, reduction of T wave amplitude, and shortening of PR and PRc interval at a daily dose of 0.5 mg/kg. Severe changes were observed at a daily dose of 1.0 mg/kg of ADM including an increase of heart rate, elevation of R wave amplitude, reduction of S and T wave amplitude, and shortening of QT interval. The electron microscopic examination revealed that THP-treated hamsters showed separation of intercalated discs, formation of myelin structure, and dilatation of T-tubules at a daily dose of 1.0 mg/kg. Similar changes were caused by ADM at a daily dose of 0.25 to 1.0 mg/kg.(ABSTRACT TRUNCATED AT 400 WORDS)
Phase I and II carcinogen metabolism gene expression in human lung tissue and tumors. (2003)

Regulation of carcinogen metabolism genes expressed in human lung seems impacted by hormonal and gender factors, as well as ongoing tobacco exposure. Expression differences between tumor and nontumor tissue in this pathway have both susceptibility and therapeutic implications.
Reactivity of metal carbide clusters: alkylation and protonation of [Fe5(CO)14C]2- (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactivity of metal carbide clusters: alkylation and protonation of [Fe5(CO)14C]2-J. W. Kolis, F. Basolo, and D. F. ShriverCite this: J. Am. Chem. Soc. 1982, 104, 21, 5626–5630Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October 1982https://pubs.acs.org/doi/10.1021/ja00385a011https://doi.org/10.1021/ja00385a011research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Collaborative development of data curation profiles on a wiki platform (2013)

Wiki technologies have proven to be versatile and successful in aiding collaborative authoring of web content. Multitude of users can collaboratively add, edit, and revise wiki pages on the fly, with ease. This functionality makes wikis ideal platforms to support research communities curate data. However, without appropriate customization and a model to support collaborative editing of pages, wikis will fall sort in providing the functionalities needed to support collaborative work. In this paper, we present the architecture and design of a wiki platform, as well as a model that allow scientific communities, especially disaster response scientists, collaborative edit and append data to their wiki pages. Our experience in the implementation of the platform on MediaWiki demonstrates how wiki technologies can be used to support data curation, and how the dynamics of the FLOSS development process, its user and developer communities are increasingly informing our understanding about supporting collaboration and coordination on wikis.
Surgical treatment of a solitary pulmonary metastasis from thyroidcancer resected 12 years earlier. (2002)

62歳女性, 甲状腺乳頭癌術後12年目に, 胸部X線で右肺上葉に径1.5cm大の孤立性病変の指摘を受け, 当施設を紹介された. 胸部CTでは, 陰影は境界明瞭な類円形を呈し, 良性腫瘍あるいは肉芽腫等を含む炎症性腫瘤が疑われ, 経過観察とされた. 半年後のCTで僅かに増大傾向を認めたため手術となった. 開胸下術中肺穿刺細胞診で核内封入体を認める乳頭癌との診断を得, 右肺上葉切除術を行った. 術後病理検査ではサイログロブリンに対する免疫染色で陽性に染まり, 甲状腺乳頭癌の肺転移と診断された. 本症例は, 甲状腺癌術後12年経って見つかった孤立性病変であることより, 術前に甲状腺癌肺転移と診断することが困難であった. 特に孤立性の甲状腺癌肺転移の外科切除報告はまれであり, 若干の文献的考察を加え報告する.
Application of current-algebra techniques to soft-pion production by the weak neutral current:<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>V</mml:mi></mml:math>,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>A</mml:mi></mml:math>case (1975)

We apply current-algebra techniques to study the constraints imposed on neutral-current-induced soft-pion production, using as input existing bounds on neutrino-proton elastic scattering and existing data on neutral-current-induced deep-inelastic scattering. In the case of a purely isoscalar weak neutral current, a simple soft-pion argument relates the cross section for threshold (in pion-nucleon invariant mass) weak pion production directly to the cross section for neutrino-proton elastic scattering. Hence, a bound on the latter cross section implies a bound on the former. To apply the method away from threshold and to nonisoscalar neutral currents, we extend a model which we had developed earlier for weak pion production in the (3,3) resonance region so as to include the low-energy-theorem constraints. Numerical work using the extended model shows that a threshold peak (now attributed to background) in preliminary Argonne data on $v+n\ensuremath{\rightarrow}v+p+{\ensuremath{\pi}}^{\ensuremath{-}}$ would have implied a threshold cross section much larger than can be obtained with any neutral current formed solely from members of the usual $V$, $A$ nonets. We analyze recently reported Brookhaven National Laboratory results for neutral-current-induced soft-pion production under the simplifying assumption of a purely isoscalar $V$, $A$ neutral current. We find in this case that the magnitude of the Brookhaven observations exceeds the theoretical maximum by more than a factor of 2 unless the assumed isoscalar current either contains a vector part with an anomalously large gyromagnetic ratio $|g|=|\frac{2{M}_{N}{F}_{2}}{{F}_{1}}|$ or involves the ninth (${\mathrm{SU}}_{3}$ singlet) axial-vector current. A vector part with a large $|g|$ value leads to characteristic modifications in the pion-nucleon invariant-mass spectrum for $M(\ensuremath{\pi}N)\ensuremath{\le}1.4$ GeV, an effect which should be testable in high-statistics experiments. Two other qualitative predictions of isoscalar $V$, $A$ structures are (i) except for a narrow range of values of $g$, constructive $V$, $A$ interference in $v+N\ensuremath{\rightarrow}v+N+\ensuremath{\pi}$ implies constructive interference in $v+p\ensuremath{\rightarrow}v+p$ and vice versa, and (ii) if $V$, $A$ interference is observed in neutral weak processes then (as is well-known) the neutral interaction may make a parity-violating contribution to the $\mathrm{pp}$, $\mathrm{ep}$, and $\ensuremath{\mu}p$ interactions. These features may help to distinguish $V$, $A$ neutral-current couplings from alternative coupling types, which will be discussed in detail in subsequent papers of this series.
Effect of vascular volume and edema on wave propagation in canine lungs (1990)

The velocities of longitudinal and transverse stress waves transmitted through inflated lung parenchyma depend on the lung stiffness, as defined by the bulk and shear moduli, and the lung density. We examined the relationship between stress wave velocities and lung density. A saline-filled reservoir was connected to the vessels of caudal dog lobes held inflated at 5 cmH2O transpulmonary pressure, and vascular volume and extravascular lung water were increased in steps by increasing vascular pressure. At each step, we measured the transmitted signals at locations 2 and 7 cm from an impulse surface distortion by means of microphones embedded in the lung surface. Longitudinal and transverse wave velocities were computed by using cross-correlation analysis of microphone signal pairs. Both wave velocities decreased as lung density increased: as a first approximation, wave velocities were inversely proportional to the square root of lung density. This behavior is consistent with the propagation of small-amplitude stress waves through an elastic continuum. Estimated bulk and shear moduli were 26 and 3.5 cmH2O, respectively, and were consistent with results from quasi-static deformation tests.
Antimycobacterial and Antiplasmodial Cyclodepsipeptides from the Insect Pathogenic Fungus Paecilomyces tenuipes BCC 1614 (2000)

Bioassay-guided fractionation of the crude extract from the insect pathogenic fungus Paecilomyces tenuipes BCC 1614 led to the isolation and identification of two antimycobacterial and antiplasmodial cyclodepsipeptides, beauvericin and beauvericin A.
Role of Insulin in Work-Induced Growth of Skeletal Muscle (1968)

Although insulin treatment was necessary for total body growth in alloxandiabetic rats, work-induced hypertrophy of the soleus and plantaris muscles could be induced in such animals without insulin. Compensatory growth proceeded to a similar extent in diabetic and normal rats. (Endocrinology83: 1071, 1968)
ChemInform Abstract: A New Metastable Thin‐Film Strontium Tantalate Perovskite. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effects of Nickel on the Activity of Nitrogen in Austenite (1963)

The nitrogen solubility in austenite was measured on Fe-Ni binary alloy in order to study the effect of nickel on the activity of nitrogen in austenite and to obtain the interaction parameter of nickel. Samples used were the Fe-Ni alloys with Ni content up to 100% and the experimental temperatures were 1050° and 1250°C. Ni increases the activity of nitrogen in austenite and the interaction parameter εN(Ni) is 4.5 at 1050°C and 4.1 at 1250°C.The nitrogen solubilities in pure γ-iron under various partial pressure of nitrogen were measured at 1150°C and result shows that Sieverts’ law is obeyed for nitrogen absorption in γ-iron.A close relationship between the interaction parameters and the atomic number of the added elements was observed and it was also found that the absolute value of the interaction parameter was decreased with the increase in temperature.
A probabilistic fatigue analysis of multiple site damage (1994)

The variability in initial crack size and fatigue crack growth is incorporated in a probabilistic model that is used to predict the fatigue lives for unstiffened aluminum alloy panels containing multiple site damage (MSD). The uncertainty of the damage in the MSD panel is represented by a distribution of fatigue crack lengths that are analytically derived from equivalent initial flaw sizes. The variability in fatigue crack growth rate is characterized by stochastic descriptions of crack growth parameters for a modified Paris crack growth law. A Monte-Carlo simulation explicitly describes the MSD panel by randomly selecting values from the stochastic variables and then grows the MSD cracks with a deterministic fatigue model until the panel fails. Different simulations investigate the influences of the fatigue variability on the distributions of remaining fatigue lives. Six cases that consider fixed and variable conditions of initial crack size and fatigue crack growth rate are examined. The crack size distribution exhibited a dominant effect on the remaining fatigue life distribution, and the variable crack growth rate exhibited a lesser effect on the distribution. In addition, the probabilistic model predicted that only a small percentage of the life remains after a lead crack develops in the MSD panel.
Reducing Risk on Machinery: A Field Evaluation Pilot Study of Risk Assessment (2008)

A pilot evaluation of the ANSI B11-TR3 Machinery Risk Assessment/Risk Reduction (RA/RR) Guideline was conducted. The TR3 guideline was introduced into five companies on one machinery system in each company with a second machine system serving as a control. A pre-post investigation was performed with safety conditions measured pre and post in both treatment and control and with risk reduction score measured only in the treatment machine system. NIOSH provided a commercially available risk assessment software to facilitate the process. Evaluation measures included avoided injuries, reduced exposure to machinery hazards, pretest and posttest knowledge demonstration, assessment of group processes following training, correct implementation of the guidelines, and degree to which risk reduction recommendations were implemented. The qualitative results of this pilot effort appear to be the best indicators for the way ahead in industrial machine risk assessment. All companies indicated that they derived value in participating in this study and in conducting risk assessments. Quantitative study results suggest that: (1) as measured by the knowledge of the participants before and after the TR3 training, the guidelines can be effective at enhancing employee knowledge of safe machine operations and (2) although the injury reduction trends appear successful, the small sample size in the study size should be considered in interpreting these early results.
PhySG: Inverse Rendering with Spherical Gaussians for Physics-based Material Editing and Relighting (2021)

We present PhySG, an end-to-end inverse rendering pipeline that includes a fully differentiable renderer, and can reconstruct geometry, materials, and illumination from scratch from a set of images. Our framework represents specular BRDFs and environmental illumination using mixtures of spherical Gaussians, and represents geometry as a signed distance function parameterized as a Multi-Layer Perceptron. The use of spherical Gaussians allows us to efficiently solve for approximate light transport, and our method works on scenes with challenging non-Lambertian reflectance captured under natural, static illumination. We demonstrate, with both synthetic and real data, that our reconstructions not only enable rendering of novel viewpoints, but also physics-based appearance editing of materials and illumination.
Stellar Exotica in 47 Tucanae (2008)

We present far-ultraviolet (FUV) spectroscopy obtained with <i>HST</i> for 48 blue objects in the core of 47 Tuc. Based on their position in a FUV-optical color-magnitude diagram, these were expected to include cataclysmic variables (CVs), blue stragglers (BSs), white dwarfs (WDs), and other exotic objects. For a subset of these sources, we also construct FUV-NIR spectral energy disributions. Based on our analysis of this extensive data set, we report the following main results. (1) We spectroscopically confirm 3 previously known or suspected CVs via the detection of emission lines and find new evidence for dwarf nova eruptions in two of these. (2) Only one other source in our spectroscopic sample exhibits marginal evidence for line emission, but predicted and observed CV numbers still agree to within a factor of about 2-3. (3) We have discovered a hot (T<sub>eff</sub> = 8700 K), low-mass (M = 0.05 M<sub>☉</sub>) secondary star in a previously known 0.8 day binary system. This exotic object is probably the remnant of a subgiant that has been stripped of its envelope and may represent the "smoking gun" of a recent dynamical encounter. (4) We have found a helium WD, the second to be optically detected in 47 Tuc, and the first outside a millisecond-pulsar system. (5) We have discovered a BS-WD binary system, the first known in any globular cluster. (6) We have found two additional candidate WD binary systems with putative main sequence and subgiant companions. (7) We estimate the WD binary fraction in the core of 47 Tuc to be 15%<sup>+ 17%</sup><sub>-9%</sub> (stat)<sup> + 8%</sup><sub>-7%</sub> (sys). (8) One BS in our sample may exceed twice the cluster turnoff mass, but the uncertainties are large. Taken as a whole, our study illustrates the wide range of stellar exotica that are lurking in the cores of GCs, most of which are likely to have undergone significant dynamical encounters.
Differential regulation of tumor necrosis factor α and transforming growth factor β production by the plasminogen activator inhibitor 1 in endothelial and cancer cells (2010)

The plasminogen activator inhibitor (PAI-1) is the key component of fibrynolytic system, its synthesis is rapidly activated by cytokines and mediators driving inflammatory response, both acute and persistent low-grade. While tumor necrosis factor α (TNF-α) and transforming growth factor β (TGF-β) are established potent direct stimulators of PAI-1 production in numerous tissues, little is known of any feed- back regulation that might be accountable for effects of PAI-1 on their synthesis. Present study provides evidence for the existence of negative feed-back regulation between PAI-1 and its potent activator TGF-β in endothelial cells. Dose-dependent inhibition of TGF-β production was observed in HUVEC cultures with physiological (10 µg/ml) and supraphysiological (100 µg/ml) (p < 0.02) PAI-1 concentrations exerting significant suppressive effect in comparison to control (respectively p < 0.05; p < 0.02) as well as cultures spiked with subphysiological PAI-1 dose of 1 µg/ml (p < 0.0001; p < 0.02). No such regulation was demonstrated for cancer cells of lung and prostate origin which might implicate different regulatory mechanism in neoplastic cells. Similarly, no functional interplay between PAI-1 and TNF-α levels in 24 hrs cultures of any evaluated cell lines was observed.
Distributed-directory scheme: scalable coherent interface (1990)

The scalable coherent interface (SCI), a local or extended computer backplane interface being defined by an IEEE standard project (P1596), is discussed. the interconnection is scalable, meaning that up to 64 K processor, memory, or I/O nodes can effectively interface to a shared SCI interconnection. The SCI sharing-list structures are described, and sharing-list addition and removal are examined. Optimizations being considered to improve the performance of large system configurations are discussed. Request combining, a useful feature of linked-list coherence, is described. SCI's optional extensions, including synchronization using a queued-on-lock bit, are considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Forcing, intermittency, and land surface hydrologic partitioning (1997)

Because of sampling problems, the precipitation estimates from satellite remote sensing are aggregated over time (typically monthly) and over space. Since land surface hydrologic processes have threshold and nonlinear dependencies on precipitation, coarse‐resolution precipitation observations may not be directly used in hydrologic models. Differences in the character of intermittency of precipitation, the averaged values remaining the same, can in fact yield large differences in the hydrologic partitioning and therefore in the resulting climate. In this paper an equilibrium hydrologic model is used to study the influence of intermittency on the way precipitation is partitioned into different hydrological quantities. The parameters defining intensity and duration of storms are varied (keeping total precipitation volume constant), and the resulting effects on the partitioning into runoff, evaporation, recharge, and soil moisture storage are determined. It is found that the character of intermittency in storm arrivals has a large impact on the hydrologic partitioning. Furthermore, investigations on the sensitivity of hydrologic partitioning on soil type and water table depth show that rainfall intermittency plays a major role irrespective of these other factors. Runoff generation, evaporation, and groundwater recharge are the three main components of the water balance. Depending on the soil type and climate, the main competition is between different combinations of these three loss mechanisms. It is concluded that the temporal structure of storms has a strong influence on the long‐term equilibrium state of the hydrological system.
Extracellular protein secretion of cultured normal and Pagetic osteoblasts (1993)

Two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) has been used to map the extracellular secretory activity of normal osteoblasts. The proteins osteonectin, bone sialoprotein, and both the C-telopeptide of collagen I together with collagen I have now been positionally identified. In addition the secretory differences which exist between normal and Pagetic osteoblasts have been mapped with the Pagetic osteoblasts shown to consistently secrete an altered 30 kDa C-telopeptide of collagen type I. The use of the diphosphonate Pamidronate in the treatment of Paget's disease of bone has beneficial effects with suppression of the bone isoenzyme marker alkaline phosphatase. It has been reported that diphosphonates directly inhibit human osteoblast secretory function as well as osteoclast metabolism. The effects of Pamidronate on the secretory activity of normal and Pagetic osteoblast cultures was also investigated. The extracellular protein secretion of normal and Pagetic osteoblasts was not affected by Pamidronate treatment as assessed by 2-D PAGE. This technique allows a comprehensive multiparameter assessment of extracellular secretory activity in normal and diseased states. The findings show that the Pagetic osteoblasts cultured in vitro are functionally abnormal and they support the hypothesis that the underlying problem in Paget's disease is characterised by disorder of osteoblast and osteoclast interactions.