gebhart/patrepeval huggingface dataset:
Mechanism of Control of Hepatic Glycogenesis by Insulin (1973)

Insulin produces an increase in the conversion of the D form (glucose-6-P dependent) of liver glycogen synthase to the I form (glucose-6-P independent) when injected intravenously into fed alloxan diabetic rats. Insulin activates glycogen synthase previously inactivated by glucagon in isolated perfused livers from normal rats, while increasing [14C]glucose incorporation into glycogen and decreasing glucagon-stimulated glucose production. This change in synthase activity is associated with a decrease in synthase (protein) kinase activity and tissue adenosine 3′,5′-monophosphate levels when insulin is used to antagonize the effects of glucagon. Finally, insulin alone has a direct effect on the activation of glycogen synthase (D to I shift) in perfused livers from normal rats if insulin infusion is begun after an initial 30-min perfusion period. This effect is maximal between 6 and 15 min and is no longer present after 30 min. Associated changes include an increase in [14C]-glucose incorporation into glycogen at 10 min and a decrease in synthase kinase activity at 6 and 15 min. This decrease in kinase activity is not associated with a decrease in apparent hepatic concentrations of adenosine 3′,5′-monophosphate.
Cloud microorganisms, an interesting source of biosurfactants. (2019)

International audience
Effects of α1 -Inhibition on Lipid Metabolism in the Rat (1987)

Prazosin or doxazosin, selective α1-adrenergic receptor inhibitors used in the treatment of hypertension, are known from clinical studies to lower plasma lipids. When diets and dosing regimens are carefully controlled, both agents produce similar effects on plasma lipids in rats, i.e., decreases in triglycerides and in the non-high density lipoprotein (non-HDL) fraction of cholesterol. In order to conduct these studies, models of rats partially fasting (PF) and eating a high-sucrose diet were developed. The effects of prazosin 2.3 mg/kg/day and doxazosin 20 mg/kg/day on plasma levels of triglycerides, total and HDL cholesterol, free fatty acids (FFA), ketones, and other metabolites were measured in rats in the fed, fasting, or PF states, at various times after a meal, and with a high-cholesterol diet. The pattern of responses leads to the hypothesis that, under conditions of partial or complete fasting, α1adrenergic receptor inhibition can alter intrahepatic FFA metabolism, causing increased ketogenesis and diminished triglyceride synthesis, possibly through potentiation of β-adrenergic or related pathways. If these concepts prove to be valid in humans, they suggest that factors such as the rate of very-low-density lipoprotein (VLDL) production or the state of sympathetic nervous activity may influence the changes in lipids induced by these agents.
ChemInform Abstract: SUBSTITUENT EFFECTS ON THE (1,5)‐SIGMATROPIC SHIFT (1976)

Abstract Der beschleunigende Einfluß der Substituenten in den Dienen (I) auf die Titelreaktion zu den Produkten (II) nimmt von Dimethylamino zu C1 in der aufgeführten Reihenfolge ab.
Neuropsychological Effects of Bilateral Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease (2006)

The pathophysiology of the observed deficit remains ill defined. However, despite a small sample size, the study provides further evidence that bilateral STN-DBS in PD patients can be associated with negative neuropsychological outcome in word fluency, especially in elderly patients. Implications regarding patient selection for bilateral STN-DBS and recommendations for future research are further discussed.
Sur un appareillage semi-automatique destiné à l'étude des réactions d'hydruration avec des métaux ou des alliages (1986)

Un appareil semi-automatique destiné à mesurer avec précision les quantités d'hydrogène absorbées ou desorbées par des métaux purs ou des alliages a été mis au point. Il est conçu de manière à permettre des mesures volumétriques à pression et température constantes. La fidélité, la précision, la facilité d'emploi et l'automatisme de cet appareillage se sont révélés être des qualités indispensables pour l'etude des réactions d'hydruration. De plus le réacteur peut être rapidement commuté du compartiment utilisé pour l'absorption àcelui destine a la désorption et vice-versa. Les réactions d'absorption et de désorption de l'hydrogène par l'alliage CeMg12 ont été étudiées a titre d'exemple.
[Papers] Separation of Multi-path Components in Sweep-less Time-of-flight Depth Imaging with a Temporally-compressive Multi-aperture Image Sensor (2018)

This paper demonstrates to separate multi-path components caused by specular reflection with temporally compressive time-of-flight (CToF) depth imaging. Because a multi-aperture ultra-high-speed (MAUHS) CMOS image sensor is utilized, any sweeping or changing of frequency, delay, or shutter code is not necessary. Therefore, the proposed scheme is suitable for capturing dynamic scenes. A short impulse light is used for excitation, and each aperture compresses the temporal impulse response with a different shutter pattern at the pixel level. In the experiment, a transparent acrylic plate was placed 0.3m away from the camera. An objective mirror was placed at the distance of 1.1 m or 1.9m from the camera. A set of 15 compressed images was captured at an acquisition rate of 25.8 frames per second. Then, 32 subsequent images were reconstructed from it. The multi-path interference from the transparent acrylic plates was distinguished.
Metal atom synthesis of metallaboron clusters. 8. Synthesis of new cobalt, iron, and nickel clusters derived from 2,6-C2B7H11. Structural characterization of 2-[.eta.6-C6(CH3)3H3]Fe-1,6-C2B7H9, 6-[.eta.6-C6(CH3)3H3]Fe-9,10-C2B7H11, and 5,7,8-(CH3)3-11,7,8,10-[.eta.3-C4(CH3)4H]NiC3B7H7 (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal atom synthesis of metallaboron clusters. 8. Synthesis of new cobalt, iron, and nickel clusters derived from 2,6-C2B7H11. Structural characterization of 2-[.eta.6-C6(CH3)3H3]Fe-1,6-C2B7H9, 6-[.eta.6-C6(CH3)3H3]Fe-9,10-C2B7H11, and 5,7,8-(CH3)3-11,7,8,10-[.eta.3-C4(CH3)4H]NiC3B7H7James J. Briguglio and Larry G. SneddonCite this: Organometallics 1986, 5, 2, 327–336Publication Date (Print):February 1, 1986Publication History Published online1 May 2002Published inissue 1 February 1986https://pubs.acs.org/doi/10.1021/om00133a023https://doi.org/10.1021/om00133a023research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: Synthesis and Antiinflammatory Activity of 1‐(2,6‐Dichlorophenyl)indolin‐2‐one Derivatives. (1987)

Abstract Starting with the oxoindoline (I), the derivatives (II) ‐ (V) and (VII) are prepared by usual methods.
Hyperdimensional Analysis of Amino Acid Pair Distributions in Proteins (2011)

Our manuscript presents a novel approach to protein structure analyses. We have organized an 8-dimensional data cube with protein 3D-structural information from 8706 high-resolution non-redundant protein-chains with the aim of identifying packing rules at the amino acid pair level. The cube contains information about amino acid type, solvent accessibility, spatial and sequence distance, secondary structure and sequence length. We are able to pose structural queries to the data cube using program ProPack. The response is a 1, 2 or 3D graph. Whereas the response is of a statistical nature, the user can obtain an instant list of all PDB-structures where such pair is found. The user may select a particular structure, which is displayed highlighting the pair in question. The user may pose millions of different queries and for each one he will receive the answer in a few seconds. In order to demonstrate the capabilities of the data cube as well as the programs, we have selected well known structural features, disulphide bridges and salt bridges, where we illustrate how the queries are posed, and how answers are given. Motifs involving cysteines such as disulphide bridges, zinc-fingers and iron-sulfur clusters are clearly identified and differentiated. ProPack also reveals that whereas pairs of Lys residues virtually never appear in close spatial proximity, pairs of Arg are abundant and appear at close spatial distance, contrasting the belief that electrostatic repulsion would prevent this juxtaposition and that Arg-Lys is perceived as a conservative mutation. The presented programs can find and visualize novel packing preferences in proteins structures allowing the user to unravel correlations between pairs of amino acids. The new tools allow the user to view statistical information and visualize instantly the structures that underpin the statistical information, which is far from trivial with most other SW tools for protein structure analysis.
The <math alttext="$V$"> <mi>V</mi> </math>-transform: A tool for analysis of control systems robustness with respect to disturbance model uncertainty (1997)

<p>This work is motivated by the need forr tools for the analysis of disturbance model uncertainty in feedback control systems. Such tools are developed in this paper for the case where the disturbance is modeled as the output of a first-order filter which is driven by white noise and whose bandwidth, <math alttext="$omega _{mathrm{d}} $"> <mrow> <msub> <mi>&omega;</mi> <mtext>d</mtext> </msub> </mrow> </math>, and gain, <math alttext="$K$"> <mi>K</mi> </math>, are uncertain. An analytical expression for the steady-state output variance as a function of <math alttext="$omega _{mathrm{d}} $"> <mrow> <msub> <mi>&omega;</mi> <mtext>d</mtext> </msub> </mrow> </math> is derived: This function is referred to as a <math alttext="$V$"> <mi>V</mi> </math>-transform, and is denoted by <math alttext="$Vleft( G ight)left( {omega _{mathrm{d}} } ight)$"> <mrow> <mi>V</mi> <mrow> <mo>(</mo> <mi>G</mi> <mo>)</mo> </mrow> <mrow> <mo>(</mo> <mrow> <msub> <mi>&omega;</mi> <mtext>d</mtext> </msub> </mrow> <mo>)</mo> </mrow> </mrow> </math> , where <math alttext="$Gleft( s ight)$"> <mrow> <mi>G</mi> <mrow> <mo>(</mo> <mi>s</mi> <mo>)</mo> </mrow> </mrow> </math> is the closed-loop transfer function from disturbance to output. Properties of <math alttext="$V$"> <mi>V</mi> </math>-transforms are investigated and the notions of <emph>disturbance gain margin</emph> and <emph>disturbance bandwidth margin</emph>, both measures of robustness with respect to disturbance model uncertainty, are introduced. Using these new tools, it is shown that there is a fundamental robustness performance limitation if the plant has nonminimum-phase zeros, but no such limitation in the minimum-phase case.</p>
Meningitis in Cancer Patients: Changes Accompany Medical Advances (2008)

Meningitis in cancer patients is an uncommon but serious disease with high morbidity and mortality. Advances in medical and surgical treatments for
Comparison of acetylmethadol and methadone in the treatment of long-term heroin users. A pilot study (1970)

In a double-blind controlled study, d1-α-acetylmethadol hydrochloride a synthetic congener of methadone hydrochloride with a 72- to 96-hour duration of action was compared to methadone in the treatment of long-term compulsive heroin users. The subjects were ambulatory patients whose conditions were already stabilized with oral administration of methadone. Over a five-week period of observation there were no differences in social adjustment between those patients whose conditions were maintained with a daily methadone regimen and those given d1-α-acetylmethadol three times a week.
A Novel Cellulose-Based Hydrophilic Wafer Matrix for Rapid Bioactive Delivery (2007)

A lyophilized polymeric wafer matrix was developed for rapid drug delivery via the oramucosal route. Lyophilization produced a porous wafer matrix that allowed simulated saliva (SS) to be rapidly absorbed into the hydrophilic structure. This surge of SS led to rapid disintegration of the wafer matrix. Hydroxypropylcellulose (HPC) was selected as the polymeric material based on its low gelatin potential. Other excipients incorporated into the system were lactose and mannitol as diluents, and glycine was utilized as a collapse inhibitor. A face-centered central composite design was employed to establish the significant effects of the independent formulation variables on the physico-chemical and physico-mechanical properties of the wafer matrix. The formulation variables investigated were, HPC concentration, diluent type and concentration, glycine concentration and fill volume. An analysis of these variables elucidated the influential factors that may be used to form an effective wafer matrix. HPC concentration significantly affected the wafer matrix disintegration rate ( P = 0.003), influx rate of SS ( P = 0.011) and wafer matrix friability ( P = 0.023). Diluent concentration had a significant effect on the wafer matrix tolerance ( P = 0.029) and wafer matrix friability ( P = 0.032). Statistical optimization was performed using constrained and artificial neural network techniques to predict ideal wafer formulation. Karl Fischer titrations revealed the reliability of the wafer matrices when small quantities of moisture were absorbed while being stored under ambient conditions.
Design and Modelling of a Parallel Data Server for Telecom Applications (2004)

Telecom databases are databases used in the operation of the telecom network and as parts of applications in the telecom network. The first telecom databases were Service Control Points (SCP) in Intelligent Networks. These provided mostly number translations for various services, such as Freephone. Also databases that keep track of the mobile phones (Home Location Registers, HLR) for mobile telecommunications were early starters. SCPs and HLRs are now becoming the platforms for service execution of telecommunication services. Other telecom databases are used for management of the network, especially for real-time charging information. Many information servers, such as Web Servers, Cache Servers, Mail Servers, File Servers are also becoming part of the telecom databases. These servers have in common that they all have to answer massive amounts of rather simple queries, that they have to be very reliable, and that they have requirements on short response times. Some of them also need lar...
A graphical tool for the analysis of network observability and state estimation algorithms (1999)

This paper describes a software tool that has been developed to facilitate the study of state estimation and network observability analysis algorithms. In addition to these functions, the software package also supports a power flow function by which automatic creation of consistent measurement sets is facilitated. All applications that make up the software package are implemented in a modular fashion to allow easy modification and/or replacement of any one or more of them in the future, to reflect changing needs as well as solution techniques. Several examples are included in the paper to illustrate the usage of the program along with its various unique features.
3D ray-tracing model including effect of inhomogeneous building surface for characterization of wireless communication channel (2007)

A ray-tracing method in conjunction with UTD (uniform theory of diffraction) has been widely used to characterize a wireless communication channel. Due to the complexity of the real situation, the ray-tracing method generally assumes buildings have homogeneous and smooth surfaces. However, in a real case, the building surface consists of many heterogeneous materials, whose shapes are also various. Hence, the scattering by the surface is much different from a homogeneous surface, which will affect the final accuracy of the ray-tracing method. In UTD, scattering mechanism by an object is mainly decomposed into two groups: reflection and diffraction. In general, the reflection in the specular direction is important, but the inhomogeneity may reduce the specular reflection drastically. In this paper, to consider the reduction of the specular reflection, we formulate the effective specular reflection based on PO (physical optics) approximation, and include the reflection in a 3D ray-tracing code. Then, we investigate the inhomogeneity effect on the final path-loss.
WSEC DNS: Protecting recursive DNS resolvers from poisoning attacks (2009)

Recently, a new attack for poisoning the cache of Recursive DNS (RDNS) resolvers was discovered and revealed to the public. In response, major DNS vendors released a patch to their software. However, the released patch does not completely protect DNS servers from cache poisoning attacks in a number of practical scenarios. DNSSEC seems to offer a definitive solution to the vulnerabilities of the DNS protocol, but unfortunately DNSSEC has not yet been widely deployed. In this paper, we proposeWild-card SECure DNS (WSEC DNS), a novel solution to DNS cache poisoning attacks. WSEC DNS relies on existing properties of the DNS protocol and is based on wild-card domain names. We show that WSEC DNS is able to decrease the probability of success of cache poisoning attacks by several orders of magnitude. That is, with WSEC DNS in place, an attacker has to persistently run a cache poisoning attack for years, before having a non-negligible chance of success. Furthermore, WSEC DNS offers complete backward compatibility to DNS servers that may for any reason decide not to implement it, therefore allowing an incremental large-scale deployment. Contrary to DNSSEC, WSEC DNS is deployable immediately because it does not have the technical and political problems that have so far hampered a large-scale deployment of DNSSEC.
A new class of miniature radiationless CPW shunt stubs printed on the center conductor (2003)

To date, only the CPW series stubs can be either implemented in the "inner" or "outer" conductor of the CPW. This paper proposes therefore a new concept for the generation of millimeter wave CPW shunt stubs within the center conductor instead of that printed in the ground plane. The study confirms the ability of CPW shunt stubs to be either implemented in the "inner" or "outer" conductor of the CPW as in case of CPW series stubs. A principal way of achieving high quality circuits is detailed and confirmed by the experimental results which show that this novel class of CPW shunt stubs have a major part to play in the miniaturization of MMICs in the future. Several new designs are presented for coplanar waveguide (CPW) open and short ended shunt stubs patterned on the center conductor. Furthermore, unlike the conventional stubs which are patterned on the ground plane, several advantages which may be derived from the use of the proposed framework are: additional degrees of freedom, lower radiation loss, high compactness and a reduction of the number of air bridges which are potentially expensive to build. The performance of the new stubs is verified by experiment over the large frequency band from 1-50 GHz. Note that different variations on the implementation of these stubs are presented in the paper.
Would the real human embryonic stem cell please stand up? (2013)

Embryonic stem cells (ESCs) are now classified into two types of pluripotency: "naïve" and "primed" based upon their differing characteristics. Conventional human ESCs have much more in common with mouse epiblast stem cells and are now deemed to be primed. Naïve human ESCs that resemble mouse ESCs have recently been generated from their primed counterpart by cellular reprogramming. Isolation of naïve hESCs from human embryos has proven to be difficult. Is the inability to capture naïve hESCs the result of suboptimal derivation conditions or because they are so transient they cannot be "captured" in vitro? Prevailing evidence surrounding this issue are inconclusive and require additional human embryo research. However, negative public opinion regarding human embryo research, may make this an uphill battle. The solution may come from cellular reprogramming.
MR-Angiographie: Erste Wahl bei der Abklärung des arteriellen Gefäßsystems (2002)

Contrast medium-enhanced, 3D MR angiography enables an extensive and diagnostically accurate evaluation of arterial vessels in the neck, thorax, abdomen, and limbs. Advances in the field of MR apparatus technology and the introduction of contrast-medium enhanced MR angiographic techniques have made this development possible. Contrast medium-enhanced MR angiography combines the intravenous bolus administration of a paramagnetic contrast medium with the rapid acquisition of 3D datasets. The possibilities for obtaining data in the thorax and abdomen within one breath-hold, the resulting high contrast between vessel lumen and surrounding soft tissue as well as the inherent 3D nature of the images allow for diagnostically relevant image quality. In many centers contrast-enhanced 3D MR angiography has widely replaced the conventional digital subtraction roentgenography for the clarification of pathologies in arterial vessels. This review presents a survey of the technical background of contrast medium eýnhanced 3D MRA. In addition, the spectrum of indications is given and discussed on the basis of clinical examples.
ChemInform Abstract: Borinic Acid Catalyzed α‐Addition to Isocyanide with Aldehyde and Water. (2011)

Abstract Various α‐hydroxyamides are synthesized.