gebhart/patrepeval huggingface dataset:
Encephalitogenic potential of myelin basic protein-specific T cells isolated from normal rhesus macaques. (1997)

Myelin basic protein (MBP)-specific T cells are implicated in the pathogenesis of multiple sclerosis and are targets of selective immunotherapies. However, autoantigen-specific T cells can also be isolated from healthy individuals. Their functional potential is unknown and obviously cannot be tested in humans. We approached this question in a closely related primate species, the rhesus monkey. CD4+ T cell lines specific for MBP were isolated from normal rhesus monkeys using the same primary limiting dilution technique that is now widely used to generate human autoreactive T cell clones in vitro. Three different epitopes were recognized by three rhesus T cell lines isolated from three different monkeys. Upon activation, all lines produced interferon-gamma, interleukin-2, tumor necrosis factor-alpha, and granulocyte/macrophage colony-stimulating factor but neither interleukin-4 nor transforming growth factor-beta. The MBP-specific T cells were injected intravenously without adjuvant into the nonirradiated autologous monkey. One of the three rhesus monkeys developed an encephalomyelitis with a pleocytosis in the spinal fluid and perivascular infiltrates in the leptomeninges, spinal nerve roots and cerebral cortex. The data demonstrate that the normal immune repertoire of a primate species contains MBP-specific CD4+ T cells that are able to induce an autoimmune encephalomyelitis upon transfer into the nonirradiated autologous recipient.
Along the Banks (2009)

RiverTime. Ecotravel on the World's Rivers . Hood, M. A. 2008 . State University of New York Press , Albany , NY . 276 pp . $23.00 (hardcover). ISBN978-0-7914-7389-4 . Many books have been published that describe interactions of humans with their natural environment. However, few are both poetic and scientific. RiverTime by Mary Hood provides a loving description of rivers of our world. She takes the reader on a nature walk and provides a guided tour in the language of a talented poet and highly competent scientist. Her descriptions of trails along rivers and the wildlife inhabiting those river banks are gentle and precise. Her tour ranges from the smallest rivers—the Apalachicola, Tensaw, and Klamath—to the mightiest—the Amazon, Yangtze, and Nile. Hood's description of the river environment is coupled with sympathetic portrayals of families along the Ganges, Nile, and small and large rivers in the United States. RiverTime is easy reading and highly enjoyable, with its descriptions of pathways, cities, and steel mills and personal observations on topics ranging from bamboo thickets along the banks of the Yangtze to portrait paintings of villages on the hillside of the Yangtze. The beauty of this book is the combination of poetry and scientific details on, for example, birds and vegetation in the universal patterns of the riverine environment. In addition, the author's strong environmental sensitivity comes through, but in a gentle manner, without strident proselytizing. For those who would like to experience the delight of hiking along the rivers of the world from their armchair, this book can provide hours of pleasant, informative, and picturesque ecotravel on the world's rivers.
.alpha.-Bergamotenes in oil of black pepper (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.alpha.-Bergamotenes in oil of black pepperGerald F. Russell, Wallace J. Murray, Carlos Julian. Muller, and Walter G. JenningsCite this: J. Agric. Food Chem. 1968, 16, 6, 1047–1049Publication Date (Print):November 1, 1968Publication History Published online1 May 2002Published inissue 1 November 1968https://doi.org/10.1021/jf60160a031RIGHTS & PERMISSIONSArticle Views74Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (228 KB) Get e-Alerts Get e-Alerts
Broadband maximum likelihood estimation of shallow ocean parameters using shipping noise (2002)

Environmental parameter estimation for a shallow ocean is addressed by using wideband shipping noise as a source of acoustic energy. Unknown locations of the broadband acoustic sources are estimated simultaneously with the ocean depth using the approximate conditional maximum likelihood estimator (CMLE). This procedure is tested via computer simulations and applied to the experimental hydrophone towed array data.
Recombinant FVIII Products (Turoctocog Alfa and Turoctocog Alfa Pegol) Stable Up to 40°C (2021)

Turoctocog alfa and turoctocog alfa pegol offer stability at 40°C for up to 3 months without jeopardizing the quality of each product. These stability characteristics may offer patients flexibility with product storage and daily use.
High-temperature operation normal incident 256/spl times/256 InAs-GaAs quantum-dot infrared photodetector focal plane array (2006)

In this letter, a 256/spl times/256 midwavelength infrared focal plane array (FPA) based on 30-period InAs-GaAs quantum-dot infrared photodetectors (QDIPs) is fabricated. The demonstrated original real-time nonuniformity corrected thermal images of hot soldering iron head with 30-Hz frame rate for the FPA are observed. Without additional light-coupling scheme, the QDIP FPA module is first operated at temperatures higher than 135 K under normal-incident condition with a 30/spl deg/ field of view and f/2 optics. For single device performances, a similar QDIP device with a 30-period InAs-GaAs QD structure is fabricated under the same processing procedure. High specific detectivity D/sup */ 1.5/spl times/10/sup 10/ cm/spl middot/Hz/sup 1/2//W and low noise current density 5.3/spl times/10/sup -13/ A/Hz/sup 1/2/ at applied voltage 0.3 V are observed.
Phonon density of states in different clathrate hydrates measured by inelastic neutron scattering (2012)

Clathrate hydrates, depending on the guest molecule type, generally exhibit one out of three different crystal structures: two cubic structures, sI and sII and one hexagonal structure, sH. In the past, our inelastic neutron scattering measurements on hydrogen clathrates have provided information on the quantum dynamics of the guest molecules in the water cages. Besides the guest dynamics, the dynamics of the water lattice itself has a large interest, due to the analogy with ice (e.g. proton disorder), and to the existence of various possible structures. Additionally, in these inclusion compounds, a coupling between the host and the guest motions is generally observed, and is considered to be relevant to explain the anomalous features of some macroscopic properties, such as thermal conductivity. Here, we present a systematic study of the H-projected phonon density of states (H-PDoS) of the lattice modes in clathrate hydrates. We have experimentally investigated the three existing structures (i.e. sI, sII, and sH) through inelastic neutron scattering measurements, and we have extracted the acoustic-optic and the librational H-PDoS's. By using proper isotopic substitutions, we have been able to tune the host scattering intensity with respect to the guest one. The studied samples consisted in three clathrates made of light water (namely, simple sI structure with Xe, simple sII structure with fully deuterated THF, and binary sH structure with MTBE and D2), and two made of heavy water (namely, simple sII structure with Ne, and simple sII structure with fully deuterated THF). The experimental results have been compared with lattice dynamics simulations performed by us.
Efficient Synthesis of<i>tert</i>-Butyl (6-Formylpyridin-2-yl)carbamic Acid (2013)

Abstract
Microgel assisted Lab-on-Fiber Optrode (2017)

Precision medicine is continuously demanding for novel point of care systems, potentially exploitable also for in-vivo analysis. Biosensing probes based on Lab-On-Fiber Technology have been recently developed to meet these challenges. However, devices exploiting standard label-free approaches (based on ligand/target molecule interaction) suffer from low sensitivity in all cases where the detection of small molecules at low concentrations is needed. Here we report on a platform developed through the combination of Lab-On-Fiber probes with microgels, which are directly integrated onto the resonant plasmonic nanostructure realized on the fiber tip. In response to binding events, the microgel network concentrates the target molecule and amplifies the optical response, leading to remarkable sensitivity enhancement. Moreover, by acting on the microgel degrees of freedom such as concentration and operating temperature, it is possible to control the limit of detection, tune the working range as well as the response time of the probe. These unique characteristics pave the way for advanced label-free biosensing platforms, suitably reconfigurable depending on the specific application.
A Storage Scheme for Multi-dimensional Databases Using Extendible Array Files. (2006)

Large scale scientific datasets are generally mod-eled as k-dimensional arrays, since this model is amenable to the form of analyses and visualiza-tion of the scientific phenomenon often investi-gated. In recent years, organizations have adopted the use of on-line analytical processing (OLAP), methods and statistical analyses to make strate-gic business decisions using enterprise data that are modeled as multi-dimensional arrays as well. In both of these domains, the datasets have the propensity to gradually grow, reaching orders of terabytes. However, the storage schemes used for these arrays correspond to those where the ar-ray elements are allocated in a sequence of con-secutive locations according to an ordering of ar-ray mapping functions that map k-dimensional in-dices one-to-one onto the linear locations. Such schemes limit the degree of extendibility of the ar-ray to one dimension only. We present a method of allocating storage for the elements of a dense multidimensional extendible array such that the bounds on the indices of the respective dimen-sions can be arbitrarily extended without reorga-nizing previously allocated elements. We give a mapping function F∗(), and its inverse F −1 for computing the linear address of an array el-ement given its k-dimensional index. The tech-nique adopts the mapping function, for realizing an extendible array with arbitrary extendibility in main memory, to implement such array files. We show how the extendible array file implementa-tion gives an efficient storage scheme for both sci-entific and OLAP multi-dimensional datasets that are allowed to incrementally grow without incur-ring the prohibitive costs of reorganizations.
U-500 Insulin in the Treatment of Antibody-Mediated Insulin Resistance (1981)

Three patients with antibody-mediated insulin resistance were treated with U-500 regular insulin subcutaneously. Insulin requirements decreased dramatically (55% to 75%) when therapy was changed from U-100 NPH pork to equivalent doses of U-500 regular pork insulin. There was no difference in antibody affinity for the insulin in these two preparations as shown by competition experiments. These observations demonstrate that U-500 insulin is a useful alternative in the treatment of antibody-mediated insulin resistance. The mechanism for this effect is yet to be determined.
COMMENTARY (2002)

In this article, Dr. Kamimura and colleagues describe a novel approach of preoperatively determining from computed tomography (CT) scans the best entry point of endoscopically placed thoracic vertebral body screws. They recommend using previously placed skin markers prior to the preoperative CT scanning to plan skin portals to provide the best angle and entry for these vertebral body screws. This procedure was used on 14 patients, placing 53 verebral body screws, with postoperative CT scanning revealing accurate screw placement without any neurologic complications. Although the authors conclude that this technique was quite helpful and could even make endoscopic screw insertion safer than open screw insertion (even though, from the article, they did not test that hypothesis at all), there certainly is potential for error in any system that deals with data acquisition and skin marking confirmation. They did not mention how the marks were contained on the skin of the patient, and whether the CT scans were done immediately before surgery or at a distant time before surgery. Were these portal sites marked with indelible ink so that they would not wash away during surgical prepping and draping? The CT scans were performed in the lateral decubitus position, and obviously it is imperative that the exact same lateral decubitus position would be used intraoperatively. It is unclear how the surgeons confirmed this fact. One of the greatest benefits that I can see from this study was actually confirming the actual length of the screw required at each level from the CT scan, since excessively long screws may place the left side of the aorta at risk for screw tips getting very close to it or actually indenting the external surface. This, in fact, is seen quite nicely in Figures 3, 4F, and 4G in the article, which had the screw angle and tip directly in line with the left-sided aorta. Although this is a very limited series on only 14 patients, the authors are to be congratulated for attempting to create a safe environment for endoscopic spine surgery. As with any new technique in spine surgery that requires additional surgeon training and expertise, there is potential for disastrous complications. Thus some surgeons may find preoperative CT scanning helpful in judging portal location, screw angulation, and screw length to make endoscopic spinal surgery as safe as possible.
<i>In vivo</i> induction of neutrophil extracellular traps by <i>Mycobacterium tuberculosis</i> in a guinea pig model (2017)

In 2004, a novel mechanism of cellular death, called 'NETosis', was described in neutrophils. This mechanism, different from necrosis and apoptosis, is characterized by the release of chromatin webs admixed with microbicidal granular proteins and peptides (NETs). NETs trap and kill a variety of microorganisms. Diverse microorganisms, including Mycobacterium tuberculosis, are NET inducers in vitro. The aim of this study was to examine whether M. tuberculosis can also induce NETs in vivo and if the NETs are bactericidal to the microorganism. Guinea pigs were intradermally inoculated with M. tuberculosis H37Rv, and the production of NETs was investigated at several time points thereafter. NETs were detected as early as 30 min post-inoculation and were clearly evident by 4 h post-inoculation. NETs produced in vivo contained DNA, myeloperoxidase, elastase, histones, ROS and acid-fast bacilli. Viable and heat-killed M. tuberculosis, as well as Mycobacterium bovis BCG were efficient NET inducers, as were unilamellar liposomes prepared with lipids from M. tuberculosis. In vitro, guinea pig neutrophils also produced NETs in response to M. tuberculosis. However, neither the in vivo nor the in vitro-produced NETs were able to kill M. tuberculosis. Nevertheless, in vivo, neutrophils might propitiate recruitment and activation of more efficient microbicidal cells.
Magnetic properties of hydrothermally synthesized greigite (Fe<sub>3</sub>S<sub>4</sub>)-I. Rock magnetic parameters at room temperature (1996)

Greigite of variable purity has been synthesized hydrothermally at ≈ 140°C by injecting a Mohr's salt solution into a sodium sulphide solution containing dissolved zerovalent sulphur, ageing for 30–960 min and rapidly quenching. Oxygen was rigorously excluded during the synthesis. Scanning electron microscope (SEM) observations yield a grain-size range up to 400 nm. The variable purity was deduced from a varying specific saturation magnetization (3–29 Am2 kg−1). The Mrs/Ms or σrs/σs ratio varies between 0.3 and 0.4, which is indicative of fine-grained greigite, concurring with SEM observations. Hysteresis measurements at low temperatures indicate the presence of grains that are superparamagnetic at room temperature. Coercivity parameters [(BO)c 13–43 mT; (Bo)cr 37–73 mT] are the highest obtained to date for synthetic greigite and compare well with those measured for natural greigite. Ranges for other rock magnetic parameters are discussed. Greigite hysteresis parameters overlap those of magnetite to a large degree. A diagnostic interparametric ratio for greigite is its high σrs/χin ratio; the range of the present greigite is 40–75 kA m−1.
Application of Mechanochemistry in the Synthesis and Discovery of New Pharmaceutical Forms: Co-crystals, Salts and Coordination Compounds (2011)

In the past decade mechanochemical methodologies, such as neat grinding and liquid-assisted grinding, have been demonstrated to be a highly efficient means of both synthesising and screening for pharmaceutical co-crystals. This chapter provides an overview of these mechanochemical methodologies, their applications to date, an overview of mechanistic details and a brief comparison with more conventional co-crystallisation methods based on solution crystallisation and slurrying. In addition to the use of mechanosynthesis in the context of pharmaceutical co-crystals, its application for pharmaceutical salt synthesis and screening is also described, as well as recent applications in the synthesis of metal–organic derivatives.
Noise coupling between power/ground nets due to differential vias transitions in a multilayer PCB (2008)

Due to the increase in board density, routing traces on different layers becomes a widely used strategy. Through-hole vias are often used to connect these traces. Those vias that penetrate power/ground plane pairs could cause noise coupling between signal and power/ground nets. At the same time, the need for clean signal transmitted to receivers results in a wide use of differential signals. This paper studies the noise coupling mechanism caused by a differential pair of vias penetrating power/ground plane pair using a physics-based via-plane model combined with transmission line models for traces. A 26-layer printed circuit board with a pair of differential vias have been modeled. The simulated results clearly demonstrate the impact of ground vias and via stubs on noise coupling.
Resonator Q-factor measurement under conditions of mode degeneration removal (2008)

A simple approach that allows determining the loaded quality factor of microwave resonators under conditions of the resonance line splitting corresponding to two-fold degenerative mode has been proposed. This technique, for example, solves the problem of superconductor surface resistance measurements using sapphire two-fold degenerative whispering gallery mode resonators.
Analyse moleculaire d'une conversion genique, d'une deletion, d'une triplication et de polymorphismes de la region "enhancer" des genes de gamma-globine (1989)

L'utilisation des techniques de clonage de sequencage, d'amplification in vitro et de detection de mutations ponctuelles a permis de mettre en evidence une conversion genique et une deletion en 5 des genes de gamma-globine humaines ainsi que plusieurs mutations de la region enhancer situee en 3 des memes genes. L'etude de l'incidence de ces mutations chez les drepanocytaires africains porteurs des differents tableaux cliniques associes a cette maladie, nous a permis d'une part d'evaluer leur role dans la regulation des genes de gamma-globuline et d'autre part d'en deduire leurs histoires phylogeniques presomptives. Nous discutons egalement l'influence phenotypique d'un chromosome porteur d'une triplication des genes gamma ainsi qu'une mutation non-sens decouverte dans le gene du facteur neuf de la coagulation qui est responsable d'une hemophilie b severe
Cytotoxicity and Cell Cycle Specificity of Homoharringtonine (1977)

The plant alkaloid, homoharringtonine, isolated from Cephalotaxus harringtonia is cytotoxic to HeLa, KB, and L cells growing in monolayer cell cultures. This effect appears to be cell-cycle specific. In synchronized KB cells, protein synthesis was preferentially inhibited in the G(1) and G(2) phases (70 and 45% inhibition, respectively) as might be expected for a protein-synthesis inhibitor.
On the chiral riccati equation (1992)

Abstract Chiral media is characterized by a particular handedness and subsequent coupling between electric and magnetic fields as evidenced by the constitutive equations. Wave propagation in stratified chiral media is examined through an initial‐value approach which yields a matrix Riccati equation for the local reflection coefficient, valid for arbitrary angle of incidence. The first reported solution for reflection from an inhomogeneous chiral transition layer is given here.
Is there a brainstem generator of chronic daily headache? ENRICO GREPPI A W A RD P A PER (2000)

Using BOLD-fMRI we have previously documented activa- tion of the red nucleus (RN) and sub- stantia nigra (SN) during sponta- neously and visually activated migraine headaches. These observa- tions prompted us to study brainstem function in chronic daily headache patients using high-resolution mag- netic resonance imaging (MRI) techniques. Seventeen chronic daily headache (CDH) patients, ten episodic migraine (EM) patients and fifteen controls (N) were imaged with a 3 tesla MRI system. For each subject, the relaxation rates R2, R2* and R2' were obtained for RN and SN. There was a significant decrease in R2' and R2* values for RN and SN in CDH compared to N and EM groups (p < 0.05), but no significant difference between the N and EM groups. A decrease in R2' and R2 * indicates reduced deoxyhe- moglobin and hence persistent acti- vation of the RN and SN in CDH patients most likely secondary to ongoing headache at the time of study. The imaging data provide objective evidence of disturbed cen- tral nervous system function in CDH.