gebhart/patrepeval huggingface dataset:
Localization and quantitation of cardiac annexins II, V, and VI in hypertensive guinea pigs (1999)

Annexins are characterized by Ca2+-dependent binding to phospholipids. Annexin II mainly participates in cell-cell adhesion and signal transduction, whereas annexins V and VI also seem to regulate intracellular calcium cycling. Their abundance and localization were determined in left ventricle (LV) and right ventricle (RV) from hypertensive guinea pigs, during the transition from compensatory hypertrophy to heart failure. Immunoblot analysis of annexins II, V, and VI revealed an increased accumulation (2.6-, 1.45-, and 2.3-fold, respectively) in LV from hypertensive guinea pigs and no modification in RV. Immunofluorescent labeling of annexins II, V, and VI; of Na+-K+-ATPase; and of sarcomeric alpha-actinin showed that in control LV and RV, 1) annexin II is present in nonmuscle cells; 2) annexins V and VI are mainly observed in the sarcolemma and intercalated disks of myocytes; 3) annexins II, V, and VI strongly label endothelial cells and adventitia of coronary arteries; and 4) annexin VI is present in the media. At the onset of heart failure, the most striking changes are the increased protein accumulation in LV and the very strong labeling of annexins II, V, and VI in interstitial tissue, suggesting a role in fibrosis development and cardiac remodeling.
Illusory Molecular Expression of “Penrose Stairs” by an Aromatic Hydrocarbon (2011)

Ascending and Descending: A combination of two helical molecules and two twisting covalent axes in the form of a macrocycle conjures an illusory molecular object that has a seemingly impossible molecular structure, that is, an endlessly descending circle that consists of an sp2-carbon network, which can be regarded as the molecular expression of Penrose stairs (see picture). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye‐Labeled Cargo (2019)

Abstract We report a new approach to monitor drug release from nanocarriers via a paclitaxel–methylene blue conjugate (PTX‐MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic‐co‐glycolic acid) (PLGA) nanoparticles (PTX‐MB@PLGA NPs). During release, PTX‐MB is spontaneously oxidized to produce a concentration‐dependent photoacoustic signal. An in vitro drug‐release study showed an initial burst release (25 %) between 0–24 h and a sustained release between 24–120 h with a cumulative release of 40.6 % and a 670‐fold increase in photoacoustic signal. An in vivo murine drug release showed a photoacoustic signal enhancement of up to 649 % after 10 hours. PTX‐MB@PLGA NPs showed an IC 50 of 78 μg mL −1 and 44.7±4.8 % decrease of tumor burden in an orthotopic model of colon cancer via luciferase‐positive CT26 cells.
High-resolution angle- and energy-resolved photoelectron spectroscopy of NO: Partial wave decomposition of the ionization continuum (1989)

We report a two-color high-resolution energy- and angle-resolved study of the photoelectrons produced in the (1+1′) REMPI of NO via rotational levels of the A 2Σ+ v=0 state. We find markedly different photoelectron angular distributions arising from production of ions in different rotational states (ΔN=0,±1,±2 transitions in the ionization step). We also observe that the ΔN=±2 angular distributions are very sensitive to the intermediate state alignment. A model is put forward in which experimental observables (angle- and energy-resolved photoelectron spectra) are used to determine the attributes (relative amplitudes and phase shifts) of a small number of interfering continuum channels that contribute to the ionization step as well as the fraction of parallel character of the ionization step. Nearly 70% of the ejected photoelectrons are associated with the ΔN=0 ionization transition; the partial wave composition of these electrons is dominated by p character. The less important ΔN=±1 peaks have both s- and d-wave character. The ΔN=±2 photoelectron peaks exhibit far more f-wave than p-wave character because destructive interference nearly removes the p-wave contribution to the angular distribution. The partial wave decomposition is used to predict angular distributions resulting from excitation of the intermediate state by different rotational branch transitions; these predictions are in excellent agreement with the measured distributions.
Conditions for Generating Nanoparticle-Stabilized CO2 Foams in Fracture and Matrix Flow (2013)

Abstract Foams used for mobility control in CO2 flooding, and for more secure sequestration of anthropogenic CO2, can be stabilized with nanoparticles, instead of surfactants, bringing some important advantages. The solid nature of the nanoparticles in stabilized foams allows them to withstand the high-temperature reservoir conditions for extended periods of time. They also have more robust stability because of the large adsorption energy required to bring the nanoparticles to the bubble interface. Silica nanoparticle-stabilized CO2-in-brine foams were generated by the co-injection of CO2 and aqueous nanoparticle dispersion through beadpacks, and through unfractured and fractured sandstone cores. Foam flow in rock matrix and fracture, both through Boise and Berea sandstones, was investigated. The apparent viscosity measured from foam flow in various porous media was also compared with that measured in a capillary tube, installed downstream of beadpacks and cores. The domain of foam stability and the apparent foam viscosity in beadpacks was first investigated with focus on how the surface wettability of nanoparticles affects the foam generation. A variety of silica nanoparticles without any surface coating and with different coatings were tested, and the concept of hydrophilic/CO2-philic balance (HCB) was found to be very useful in designing surface coatings that provide foams with robust stability. Opaque, white CO2-in-water foams (bubble diameter &lt; 100 µm) were generated with either polyethyleneglycol-coated silica or methylsilyl-modified silica nanoparticles with CO2 densities between 0.2 and 0.9 g/cc. The synergistic interactions at the surface of nanoparticles (bare colloidal silica) and surfactant (caprylamidopropyl betaine) in generating stable CO2 foams were also investigated. The common and distinct requirements to generate stable CO2 foams with 5-nm silica nanoparticles, in rock matrices and in fractures, were characterized by running foam generation experiments in Boise and Berea sandstone cores. The threshold shear rates for foam generation in matrix and in fracture, both in Boise and Berea sandstones, were characterized. The ability of nanoparticles to generate foams only above a threshold shear rate is advantageous, because high shear rates are associated with high permeability zones and fractures. Reducing CO2 mobility in these zones with foam diverts CO2 into lower permeability regions that still contain unswept oil.
Enzymatic epoxidation: synthesis of 7,8-epoxy-1-octene, 1,2-7,8-diepoxyoctane, and 1,2-Epoxyoctane by Pseudomonas oleovorans (1976)

The kinetics of the enzymatic formation of 7,8-epoxy-1-octene, 1,2-7,8-diepoxyoctane, and 1,2-epoxyoctane by growing and resting cell suspensions of Pseudomonas oleovorans are described. Formation of 1,2-epoxyoctane occurs concurrently with exponential growth on 1-octene, providing that 1-octene is in excess. Conversion of 1,7-octadiene to 7,8-epoxy-1-octene by cells growing on octane lags behind exponential growth and continues into the stationary phase, terminating upon cell death. Formation of 1,2-7,8-diepoxyoctane does not begin until the cells are well into the stationary phase and also continues until cell death. Results with growing and resting cell suspensions suggest that the various substrates compete for the same enzyme system; that viable cells are essential for substrate transport and epoxidation by whole cells; and that whole cells may concentrate and sequester the epoxides, rendering them unrecoverable by our current methods.
Mechanisms of the Adjuvant Effect of Nystatin on <i>In Vitro</i> Antibody Response of Mouse Spleen Cells (1977)

Abstract Adjuvanticity of nystatin, one of the polyenic antifungal antibiotics having as its primary target the membrane sterol of eukaryotic cells, was investigated by examining its effect on several functions of mouse spleen cells relevant to immunological phenomena in vitro . Nystatin was found to stimulate significantly DNA synthesis in thymus‐independent (B) cells but not in thymus‐dependent (T) cells. Like the other B‐cell mitogens such as bacterial lipopolysaccharide (LPS), nystatin elicited nonspecifically polyclonal antibody synthesis in mouse spleen cell cultures, and also restored antibody response of T cell‐deficient spleen cells of congenitally athymic nude mice to heterologous erythrocytes (RBC; thymus‐dependent antigen). Thus, nystatin and LPS appeared to cause similar changes in the functions of spleen cells relevant to immunological events. However, antagonism but no additive effect in the adjuvanticity was revealed between the two adjuvants. As an interesting finding, the polyclonal generation of anti‐RBC antibody‐forming cells (AFC) in the spleen cell cultures by stimulation with B‐cell mitogen, i.e., either nystatin or LPS, was not inhibited at all by inclusion of any anti‐RBC antiserum, whereas, as is well known, the generation of AFC by stimulation with the antigen was specifically suppressed by the corresponding antiserum, indicating a difference in the genesis between the mitogen‐induced AFC and the antigen‐induced AFC.
A highly efficient domain-programmable parallel architecture for iterative LDPCC decoding (2002)

We present a domain-programmable (code-independent) parallel architecture for efficiently implementing iterative probabilistic decoding of LDPC codes. The architecture is based on distributed computing and message passing. The exploited parallelism was found to be communication limited. To increase the utilization of the computational resources, we separate the routing process and state management functionalities performed by physical nodes from computation functionalities performed by function units that can be shared by multiple physical nodes. Simulation results show that the proposed architecture leads to improvements in FU utilization by 251%, 116%, and 209% compared to a hypothetical fully parallel custom implementation, a fully sequential implementation, and a proprietary FPGA custom implementation, respectively, that all use the same core FU design. Compared to an implementation on a shared-memory general-purpose parallel machine, the proposed architecture exhibits 75.6% improvement in scalability. We also introduce a novel low cost store-and-forward routing algorithm for deadlock avoidance in torus networks.
The Lotus coating for space exploration: a dust mitigation tool (2010)

The "Lotus" dust mitigation coating is a new technology that is currently being developed and tested, at NASA Goddard Space Flight Center (GSFC), as a countermeasure for addressing dust accumulation issues for long-duration human space exploration. This coating sheds dust particles utilizing anti-contamination and self-cleaning properties that minimize dust accumulation on spacecraft surfaces. Shedding of dust particles is accomplished by reducing the surface energy and the amount of surface available for attachment. The Lotus coating is designed to preserve optimal long-term performance of critical spacecraft surfaces and systems, while minimizing and/or eliminating dust accumulation. NASA is exceedingly interested in simplistic and innovative ways to mitigate dust accumulation while minimizing the impact to spacecraft mass and power requirements. Preliminary research and development indicates that the Lotus Coating has the potential to be a viable passive tool for mitigating dust on: radiator surfaces, solar array panels, habitation airlock walls, mechanism shields, astronaut EVA suits, and astronaut visors exterior coating.
INFORMATION DISSEMINATION FOR REALITY-BASED TSUNAMI DISASTER EDUCATION (2008)

Huge earthquake and tsunami on December 26th, 2004 has caused a great number of casualties around Indian Ocean rim countries especially in Banda Aceh city, in Sumatra Island, Indonesia. In a quick response to the disaster, a Japanese group of researchers led by the first author departed to Banda Aceh and surrounding areas in attempt to study the lessons by the huge earthquake and tsunami. Questionnaires were distributed to the affected people. The questionnaire’s result shows that the local people’s awareness of tsunami was very low. Other important result is that even if people had started running away just after the big earthquake, the percentage of expected survivors would have been less than 100%. The practical implication is that education, socialization, escape structures, warning system, wave resisting structures are among important factors for people to be safer against future earthquake and tsunami attacks. However, since tsunami is a rare event, the future generations may forget the disaster easily. One of the ideas prompted by the first author to local people is to build poles with the height of tsunami run up throughout the affected areas in the city. The poles have many important purposes. The idea was supported by local people and Embassy of Japan in Indonesia. To date, 85 tsunami height memorial poles are standing throughout Banda Aceh city and surrounding areas. The poles are expected to last long and convey the important message of tsunami disaster to the present and next generations.
Near-Capacity Irregular Bit-Interleaved Coded Modulation (2008)

An irregular bit-interleaved coded modulation based iterative decoding (Ir-BICM-ID) aided scheme is proposed. The irregularity of the scheme pervades the three basic components of BICM-ID, namely the encoder, the unity-rate precoder and the bit-to-symbol mapper. As a result, adaptive BICM-ID schemes constituted by irregular components are created, which are capable of approaching the capacity of coded modulation. This is achieved by creating a narrow extrinsic information transfer (EXIT) chart, using a novel EXIT curve matching algorithm. The proposed Ir-BICM-ID scheme employs irregular convolutional codes (IrCC), irregular unity-rate codes (IrURC) and irregular mappers (IrMapper).
Development of 3D bioprinting inks based on tandem crosslinked hydrogels (2013)

In the future the field of medicine will be directed towards tailored treatments and per-sonalized medicine. In personalized medicine the implant is designed for the patient’s needs in terms of the shape of the implant and the cells encapsulated into the implant, which are harvested from the patient itself. By these means, the produced implant is mimicking the designated tissue and the cells are fully biocompatible with the surround-ing tissue. By utilizing rapid prototyping in biomaterial scaffold or tissue graft production, the patient optimized implants could be produced. One promising rapid prototyping technique is bioprinting. \nThe aim of this thesis was to investigate different material combinations to be used as bioinks for cartilage production. In this thesis, three cartilage specific tandem cross-linked hydrogel bioinks were created and analyzed. Furthermore, different constructs and printed composite structures were created to prove the printability and resolution of these bioinks. Materials used in this study were hyaluronic acid, chondroitin sulfate and dextran which were grafted with methacrylate groups. These materials were mixed with hyaluronic acid grafted with poly(N-isopropylacrylamine) (HA-PNIPAM). \nThe two-component hydrogels used were novel in regards to utilize HA-PNIPAM in 3D bioprinting and in using tandem crosslinking combining thermo and photosensitive crosslinking in the printing. By combining the two crosslinking methods we were able to create three different bioinks mimicking the cartilage layered structures. Tandem crosslinked bioinks kept the resolution of the printing process and they had an increased modulus after UV curing. The implants produced had insufficient mechanical properties compared to native cartilage, however, the printability and the resolutions were on suf-ficient levels. Further development to control the temperature gelation is required and the viability assays for the bioinks should be investigated.
Large gain of gaseous ammonia near 1 THz (2016)

Large gain of optically pumped gas (ammonia) was obtained at 1.073 and 1.068 THz. Tunable quantum cascade laser allows to excite sharp mid-infrared transitions of ammonia close to 967 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> . Obtained population inversion of umbrella modes near 1 THz is not accessible by any other pumping methods. Exceptionally high gain demonstrated can be used for future terahertz applications. The proposed method of measurement has high potential for evaluation of gain for different gases optically pumped by quantum cascade lasers.
HYPERDYNAMIC SEPSIS IN A PRIMATE MODEL OF PERITONITIS. (1996)

Kinasewitz, G. T.; Randolph, M.; Haddad, P. A.; Chang, A. K.; Peer, G.; Carey, D.; Kosanke, S.; White, G.; Hinshaw, L.; Taylor, F. B. Author Information
Parental Stress as a Cause and Effect of Pediatric Burn Injury (1993)

The current study reports assessments of stress for parents of children with acute burns at the time of hospital admission and during the first 5 years after injury. At each assessment, parents of children with burns report neither more nor less stress than a normal population. At the time of admission, parents of children with acute burns do not differ from the normal sample on any of the measures of parenting stress. Parents of recovering children with burns do report significant changes. They report significantly higher depressive symptoms at year 2 after the child's burn injury and lower than normal levels of depression in years 4 and 5 after the child's injury. During the recovery period, these parents also attribute their stress more often to the child with burns, whereas other parents more evenly divide blame among their children and their personal characteristics.
IMMUNE STATUS OF RECIPIENTS FOLLOWING BONE MARROW-AUGMENTED SOLID ORGAN TRANSPLANTATION1,2 (1995)

It has been postulated that the resident “passenger” leukocytes of hematolymphoid origin that migrate from whole organ grafts and subsequently establish systemic chimerism are essential for graft acceptance and the induction of donor-specific nonreactivity. This phenomenon was augmented by infusing 3×108 unmodified donor bone-marrow cells into 40 patients at the time of organ transplantation. Fifteen of the first 18 analyzable patients had sequential immunological evaluation over postoperative intervals of 5 to 17 months, (which included 7 kidney (two with islets), 7 liver (one with islets), and one heart recipient). The evolution of changes was compared with that in 16 kidney and liver nonmarrow controls followed for 4 to 5 months. The generic immune reactivity of peripheral blood mononuclear cells (PBMC) was determined by their proliferative responses to mitogens (PHA, ConA). Alloreactivity was measured by the recipient mixed lymphocyte reaction (MLR) to donor and HLA-mismatched third-party panel cells. Based on all 3 tests, the recipients were classified as donor-specific hyporeactive, intermediate, and responsive; patients who were globally suppressed made up a fourth category. Eight (53%) of the 15 marrow-treated recipients exhibited progressive modulation of donor-specific reactivity (3 hyporeactive and 5 intermediate) while 7 remained antidonor-responsive. In the nonmarrow controls, 2 (12.5%) of the 16 patients showed donor-specific hyporeactivity, 10 (62.5%) were reactive, and 4 (25%) studied during a CMV infection had global suppression of responsiveness to all stimuli.
Hypercomplex Bark-Scale Filter Bank Design Based On Allpass-Phase Specifications (2012)

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012
The K <sup>+</sup> :Cl <sup>‐</sup> Cotransporter KCC4 is Activated by Deacetylation Induced by the Sirtuin7 (SIRT7) (2015)

KCC4 is expressed at the basolateral membrane of α‐intercalated cells where modulates pH balance. KCC4 expression in increased by metabolic acidosis and the absence of KCC4 causes renal tubular acidosis. The analysis of 41 recombinant inbred mouse strains kidney transcripts (GeneNetwork database) showed a positive correlation between KCC4 and SIRT7 mRNA expression, suggesting a link between these two proteins. Thus, in the present study we determined the intrarenal distribution of SIRT7 and analyzed its effect on KCC4 expression, acetylation and activity. In presence of nicotinamide (NAM) KCC4 is acetylated and its activity and protein levels are significantly reduced in Xenopus laevis oocytes and HEK‐293 cells. On the contrary, the presence of SIRT7 and its cofactor NAD + promote KCC4 deacetylation, increasing the protein levels and activity. Additionally, KCC4 and SIRT7 interact and the presence of NAD + enhances the process in HEK cells. Similar to KCC4, metabolic acidosis increased the protein levels of SIRT7 and its co‐localization with KCC4 at the basolateral membrane of α‐intercalated cells of mice‐collecting duct. In these cells, under metabolic acidosis, SIRT7 is translocated from the nucleus to the cytoplasm, where it can interact with KCC4. Finally, SIRT7 deficient mice have diminished KCC4 protein levels in the kidney and altered renal electrolyte excretion. Our data reveal that acetylation/deacetylation processes can regulate KCC4. SIRT7 co‐localize and interacts with KCC4 up‐regulating its activity by deacetylation. The positive effect of SIRT7 on KCC4 suggests a role for this sirtuin in acid‐base and renal electrolyte handling.
A preliminary study of a hybrid fusion reactor at moderate temperature (1976)

A hybrid fission-fusion system is investigated which operates in a moderate temperature range. The fuel is LiD which is a solid at room temperature. The fusion reaction is maintained by a neutron source from a fission reactor. For a spherically concentric system with interface radius equal to 5m, and a fission neutron flux of 10 to the 13th power/sq cm sec, tge output power due to fusion is estimated to be 10 kw. The direct heating of the lattice owing to Li6 neutron capture for these same dimensions is estimated to be 23 Mw and it is concluded that the system is inefficient as a fusion device. (Author)