gebhart/patrepeval huggingface dataset:
POSITIVE CORRELATION OF T CELL SENSITIZATION WITH FREQUENCIES OF ALLOREACTIVE T HELPER CELLS IN CHRONIC RENAL FAILURE PATIENTS (1992)

Chronic renal failure patients are often "sensitized" to foreign alloantigens following renal transplantation or blood transfusion. B cell sensitization is assessed by measuring the reactivity of cytotoxic antibodies in the patient's serum against a panel of allogeneic cells (panel-reactive antibodies, [PRA]). However, this technique provides no information about T cell allosensitization. T cell allosensitization may be important since T cells play a central role in allograft rejection and since "primed" alloreactive cells--i.e., T cells that have previously encountered their specific alloantigen, are relatively resistant to immunosuppression. In order to detect T cell sensitization we used a limiting dilution analysis assay, which measured both total and primed frequencies of alloreactive T helper (Th) cells. Total alloreactive Th cell frequencies were generally high. Primed alloreactive Th cell frequencies could be detected in all patients studied, although there was considerable variation in frequencies between different patients. Frequencies of primed Th cells did not correlate with levels of PRA. However, in all three of the patients who had received DR-mismatched kidneys, and who had subsequently rejected these grafts rapidly, high primed frequencies were detected against the mismatched DR antigens. This was not the case for two patients who had lost their grafts two or more years after transplantation.
Magnetic phase diagram of the spin-Peierls and antiferromagnetic system<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">CuGe</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mi>−</mml:mi><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Si</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (1998)

Neutron-diffraction experiments have been performed for ${\mathrm{CuGe}}_{1\ensuremath{-}x}{\mathrm{Si}}_{x}{\mathrm{O}}_{3}$ single crystals over a wide range of the Si concentration (0.4, 1.0, 1.7, 1.8, 2.1, 2.6, and 5.1 at. %) to study relations between the original spin-Peierls (SP) state and the antiferromagnetic (AF) long-range ordering induced by the Si doping. The SP state is strongly suppressed with the appearance of the AF state with the small amount of Si, and disappears at the concentration of around 2.5% at low temperatures. The AF phase persists throughout the concentration range studied here. Hence, the coexistence of these two states occurs in the concentration range up to around 2.5 at. % Si. The magnitudes of the AF magnetic moment and the lattice dimerization are given as a function of $x.$ The magnetic phase diagram obtained from these experiments has been compared with the previous reports on the Si and also Zn doping.
Metallic copper-chloride interaction in a hydrogen-air flame (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetallic copper-chloride interaction in a hydrogen-air flameDavid F. Tomkins and C. W. FrankCite this: Anal. Chem. 1974, 46, 9, 1187–1190Publication Date (Print):August 1, 1974Publication History Published online1 May 2002Published inissue 1 August 1974https://pubs.acs.org/doi/10.1021/ac60345a006https://doi.org/10.1021/ac60345a006research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integrating Algebraic Functions of Views with Indexing and Learning for 3D Object Recognition (2005)

This paper focuses on the problem of 3D object recognition from different viewing angles and positions. In particular, we propose a new approach that integrates Algebraic Functions of Views (AFoVs) with indexing and learning. During training, we consider groups of point features and we represent a sparse number of views that they can produce in a k-d tree. Moreover, we learn the manifold formed by a dense number of views using mixture models and Expectation-Maximization (EM). Learning takes place in a "universal", lower-dimensional, space computed through Random Projection (RP). The images that a group of model points can produce are computed off-line using AFoVs by combining a small number of reference views that contain the group. Rigidity constraints are imposed during this step to remove unrealistic views. During recognition, groups of point features are extracted from the scene and used to retrieve from the k-d tree the most feasible model groups that might have produced them. To reduce the number of hypotheses for verification, we rank them by computing the probability that the hypothesized model group is present in the scene. Only hypotheses ranked high enough are considered for further verification. The proposed method has been evaluated using both artifical and real data, illustrating good performance.
A C++ implementation of the co-array programming model for blue gene/L (2002)

Blue Gene/L (BG/L) is a 65, 536-node massively parallel computer being developed at the IBM Thomas J. Watson Research Center that promises to revolutionize large-scale scientific computing. However, its size alone will make programming BG/L a major challenge, both from a correctness and from a performance perspective. This has motivated us to look into new programming models that have been proposed as an alternative for MPI on parallel systems. We find the Co-Array programming model attractive for its simplicity and high performance. Instead of implementing this model in the usual way, as language extensions to Fortran, we have chosen to implement it as a C++ library. This allows us to prototype and deploy this implementation with a relatively small effort, and to experiment with it on existing machines. Users also benefit, for they can experiment with this programming model early and without learning a new language. Our preliminary results indicate that parallel programs written with our C++ Co-Array library can reach good levels of speedup.
Mini-columns for Conducting Breakthrough Experiments: Design and Construction (2015)

Experiments with moderately and strongly sorbing radionuclides (i.e., U, Cs, Am) have shown that sorption between experimental solutions and traditional column materials must be accounted for to accurately determine stationary phase or porous media sorption properties (i.e., sorption site density, sorption site reaction rate coefficients, and partition coefficients or Kd values). This report details the materials and construction of mini-columns for use in breakthrough columns to allow for accurate measurement and modeling of sorption parameters. Material selection, construction techniques, wet packing of columns, tubing connections, and lessons learned are addressed.
Animal Cell Biotechnology Animal Cell Biotechnology, Vol. 1 R. E. Spier J. B. Griffiths Animal Cell Biotechnology, Vol. 2 R. E. Spier J. B. Griffiths (1987)

Animal Cell Biotechnology Get access Animal Cell Biotechnology, vol. 1. Spier R. E. Griffiths J. B., eds. Academic Press, Orlando, FL, 1985. 347 pp., illus. $55.00 (cloth).Animal Cell Biotechnology, vol. 2. Spier R. E. Griffiths J. B., eds. Academic Press, Orlando, FL, 1985. 475 pp., illus. $66.00 (cloth). James M. Robl James M. Robl Zoology Department, University of Massachusetts, Amherst, MA 01003 Search for other works by this author on: Oxford Academic Google Scholar BioScience, Volume 37, Issue 10, November 1987, Page 738, https://doi.org/10.2307/1310479 Published: 01 November 1987
<title>Adaptive wavefront correction with self-organized control system architecture</title> (1998)

We discuss an adaptive optical system having a self- organized control channel hierarchy (`adaptive' adaptive imaging system). In this system changes in the quality metric are reflected by corresponding changes to the control algorithm structure. Numerical simulations of an adaptive imaging system with a self-organized control structure demonstrate a property unusual for model-free optimization methods: the algorithm convergence speed did not change, or at times even increased, when the number of control channels N increased.
Thyroxin and Triiodothyronine in Excessive Dosage to Euthyroid Humans (1958)

The comparative effects of 3,5,3'-<i>l</i>-triiodothyronine and<i>l</i>-thyroxin in myxedema have been carefully evaluated.<sup>1</sup>These medications have also been given in physiologic dosage to euthyroid humans to evaluate the effect on the thyroid I<sup>131</sup>uptake and serum protein-bound iodine (PBI).<sup>2</sup>We have found no information on the comparative effects of "thyrotoxic" dosage of these drugs and the subsequent effect of stopping these medications. In the course of an evaluation of the effects of induced thyrotoxicosis on mental function,<sup>3</sup>interesting new data were accumulated on this aspect of thyroid hormone effect. <h3>Method</h3><h3>Subjects.</h3> —Eighteen healthy male college students ranging in age from 20 to 30 years—average age, 23 years—were screened by medical history, physical examination, 24-hour I<i>131</i>-uptake test, basal metabolic rate (BMR), serum PBI,<sup>4</sup>and serum cholesterol<sup>5</sup>determination to rule out any question of thyroid disease and to make certain that they could withstand the effects of administration of excessive amounts of
Semaphorin D acts as a repulsive factor for entorhinal and hippocampal neurons (1999)

We analysed the effects of semaphorin D on axons from the developing rat entorhinal-hippocampal formation. Explants from superficial layers of the entorhinal cortex and of the hippocampus anlage were obtained from various developmental stages and co-cultured with cell aggregates expressing semaphorin D. Neurites extending from entorhinal explants that had been isolated from early embryonic stages (E16 and E17) were not affected by semaphorin D, but were repelled at later stages (E20 and E21). Axons from hippocampal neurons explanted at E21 were also repelled by semaphorin D. In situ hybridization studies revealed expression of the semaphorin D receptor neuropilin-1 in the entorhinal cortex from stage E17 to stage P7, and in the dentate gyrus and CA1-3 regions between E17 and adulthood. These data suggest that semaphorin D is involved in the formation of the perforant pathway and acts, via the neuropilin-1 receptor, as a repulsive signal that prevents entorhinal fibres from growing into the granular layer of the dentate gyrus. These data also suggest a role for semaphorin D in the development of intrahippocampal connections.
Organometallic and organometalloidal fluorine compounds. Part XII. Bistrifluoromethylphosphinic acid and related phosphorus oxy-acids (1955)

H. J. Emeléus, R. N. Haszeldine and R. C. Paul, J. Chem. Soc., 1955, 563 DOI: 10.1039/JR9550000563
Abstract 1848: Expression of an androgen transporter, organic anion transporting polypeptide 1B3, impacts progression and treatment of prostate cancer (2012)

Abstract Organic anion transporting polypeptides (OATPs) are membrane transporters that facilitate the movement of large substrates into cells. One family member, organic anion transporting polypeptide 1B3 (OATP1B3) is aberrantly overexpressed in prostate cancer and has been shown to influx both endogenous small molecules and chemotherapy reagents. Our hypothesis is that the OATP1B3 affects tumor growth by influxing testosterone. However, little is known about the cause of OATP1B3 expression in cancer and the impact of OATP1B3 transport on tumor growth. Therefore, we completed a study investigating putative hypoxia elements in the OATP1B3 promoter region, characterizing the impact of OATP1B3 androgen transport on prostate cancer growth, and examining the effect of OATP1B3 on the efficacy of standard prostate cancer treatments. The results showed that OATP1B3 co-localized with HIF 1-alpha in prostate cancer tissues from patients, correlated significantly to HIF1A in xenograft tumors under castration (P=0.005), and confirmed HIF-1alpha elements in the SLCO1B3 promoter region. In addition, radioactive transport assays with Xenopus oocytes showed that OATP1B3 transports testosterone and dihydrotestosterone 50- to 250-fold over passive diffusion at low physiological concentrations. A prostate cancer cell line expressing OATP1B3 grew faster than untransfected in response to androgens at all concentrations. Finally, OATP1B3 increased cell sensitivity to docetaxel treatment. In summary, these data show that hypoxia and castration increases OATP1B3 expression in cancer, OATP1B3-mediated androgen transport significantly impacts prostate cancer growth and OATP1B3 impacts the efficacy of docetaxel. These data provides evidence that OATP1B3 impacts prostate cancer growth and treatment. Future studies could screen for specific inhibitors of OATP1B3-mediated androgen transport. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1848. doi:1538-7445.AM2012-1848
Deformable registration of macular oct using a-mode scan similarity (2013)

Optical coherence tomography (OCT) of the macular cube has become an increasingly important tool for investigating and managing retinal pathology. One important new area of investigation is the analysis of anatomic variably across a population. Such an analysis on the retina requires the construction of a normalized space, which is generally created through deformable registration of each subject into a common template. Unfortunately, state-of-the-art 3D registration tools fail to adequately spatially normalize retinal OCT images. This work proposes a new deformable registration algorithm for OCT images using the similarity between pairs of A-mode scans. First, a retinal OCT specific affine step is presented, which uses automated landmarks to perform global translations and individual rescaling of all the subject's A-mode scans. Then, a deformable registration using regularized one-dimensional radial basis functions is applied to further align the retinal layers. Results on 15 subjects show the improved accuracy of this approach in comparison to state of the art methods with respect to registration for labeling. Additional results show the ability to generate stereotaxic spaces for retinal OCT.
Behavioral detection of 60‐Hz electric fields by rats (1983)

Rats partially deprived of food were trained individually to press a lever in the presence of a vertical, 60-Hz electric field and not to press in its absence. Correct detections that occurred during brief, 3- or 4-s trials occasionally produced a food pellet. The probability of detecting the field was found to increase as field strength increased. The threshold of detection, ie, the field strength required for detections at a probability of 0.5 after correction for errors, was generally between 4 and 10 kV/m. The range of field strengths between almost zero and almost 100% correctness of detection was approximately 8 kV/m. A logistic function provided a good description of the increase in the detection probability with increasing field strength. These performances occurred reliably in 19 rats, some of which were studied for 2 years. Control procedures showed that the behavior required that the rat be in the electric field; the behavior was not controlled by any of several potentially confounding variables.
Maximum Crack Width in Reinforced Concrete Flexural Members (1968)

THE MAXIMUM CRACK WIDTH MEASUREMENTS FROM A NUMBER OF CRACK WIDTH INVESTIGATIONS WERE EXAMINED USING STATISTICAL METHODS. PREVIOUSLY PROPOSED EQUATIONS FOR MAXIMUM CRACK WIDTH WERE COMPARED AND NEW EQUATIONS WERE PROPOSED AS A RESULT OF THE ANALYSES. INTEREST IN CRACK WIDTHS IN FLEXURAL MEMBERS HAS BEEN STIMULATED BY THE TREND TO USE HIGH STRENGTH DEFORMED REINFORCING BARS. VARIOUS INVESTIGATIONS HAVE PRODUCED MUCH INFORMATION ABOUT THE WIDTH AND SPACING OF CRACKS. HOWEVER, DUE TO THE RELATIVELY LARGE SCATTER IN THE WIDTH OF THE LARGEST CRACKS, AND TO THE LARGE NUMBER OF INTERRELATED VARIABLES PRESENT IN REINFORCED CONCRETE BEAMS, AGREEMENT WAS LACKING AMONG THE INVESTIGATORS AS TO THE MOST PERTINENT VARIABLES INFLUENCING THE SIZE OF THE CRACKS. BY USING DATA FROM SIX DIFFERENT INVESTIGATIONS, THE SAMPLE WAS LARGE AND DIVERSE ENOUGH TO PERMIT RELIABLE STATISTICAL ANALYSES. THE MAXIMUM CRACK WIDTH MEASURED ON A BEAM AT A CERTAIN STEEL STRESS LEVEL REPRESENTED A STATISTICAL SAMPLE. IN THE COMPUTER INPUT, EACH SAMPLE WAS ACCOMPANIED BY ALL BEAM DETAILS THAT COULD INFLUENCE THE CRACK WIDTH. THE MAXIMUM CRACK WIDTH ON THE TENSION FACE OF THE BEAM AND THE MAXIMUM CRACK WIDTH ON THE SIDE OF THE BEAM AT THE LEVEL OF THE TENSILE REINFORCEMENT WERE ANALYZED SEPARATELY. THE FOLLOWING MAJOR CONCLUSIONS RESULTED FROM THE ANALYSIS OF THE MAXIMUM CRACK WIDTH: (1) THE STEEL STRESS IS THE MOST IMPORTANT VARIABLE, (2) THE DIAMETER OF THE REINFORCING BAR IS NOT A MAJOR VARIABLE, (3) THE THICKNESS OF THE CONCRETE COVER IS IMPORTANT, BUT IT IS NOT THE ONLY FACTOR REFLECTING GEOMETRY, (4) THE AREA OF THE CONCRETE SURROUNDING EACH REINFORCING BAR, A, ALSO INFLUENCES THE CRACK WIDTH, (5) THE SIZE OF THE SIDE CRACK WIDTH IS REDUCED BY THE PROXIMITY OF THE COMPRESSION ZONE (NEUTRAL AXIS) IN FLEXURAL MEMBERS, (6) THE BOTTOM CRACK WIDTH IS INFLUENCED BY THE STRAIN GRADIENT FROM THE LEVEL OF THE STEEL TO THE TENSION FACE OF THE BEAM. /ACIJP/
Fiber‐in‐Tube Design of Co<sub>9</sub>S<sub>8</sub>‐Carbon/Co<sub>9</sub>S<sub>8</sub>: Enabling Efficient Sodium Storage (2019)

Abstract The sodium‐ion battery is a promising battery technology owing to its low price and high abundance of sodium. However, the sluggish kinetics of sodium ion makes it hard to achieve high‐rate performance, therefore impairing the power density. In this work, a fiber‐in‐tube Co 9 S 8 ‐carbon(C)/Co 9 S 8 is designed with fast sodiation kinetics. The experimental and simulation analysis show that the dominating capacitance mechanism for the high Na‐ion storage performance is due to abundant grain boundaries, three exposed layer interfaces, and carbon wiring in the design. As a result, the fiber‐in‐tube hybrid anode shows a high specific capacity of 616 mAh g −1 after 150 cycles at 0.5 A g −1 . At 1 A g −1 , a capacity of ca. 451 mAh g −1 can be achieved after 500 cycles. More importantly, a high energy density of 779 Wh kg −1 and power density of 7793 W kg −1 can be obtained simultaneously.
Equilibrating Dynamic [2]Rotaxanes (2007)

Upon mixing and dehydration, 2,6-diformylpyridine and 2,2'-oxybis(ethylamine) form a dynamic combinatorial library of at least nine members. Through hydrogen bonding and other intermolecular interactions, templating dumbbell molecules select one macrocyclic member of the library, at the expense of all the others, to create [2]rotaxanes. These rotaxanes, however, retain the dynamic character of the library, since a diformylpyridine analogue can exchange with the macrocyclic component in solution. In addition, crystallization of the mixture surprisingly furnishes only the [24]crown-8-like macrocycle on its own--evidence of a kinetic selection process occurring between phase transitions.
Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex (1999)

5-HTt1A receptor agonists reduce the neuronal release of 5-hydroxytryptamine (5-HT) by activation of raphe 5-HT1A autoreceptors. Using in vivo microdialysis in unanesthetized rats, we show that the local application of the selective 5-HT1A receptor agonist 8-OH-DPAT decreased the 5-HT output to approximately 50% of controls in medial prefrontal cortex (mPFC) but not in dorsal hippocampus. The decrease in 5-HT output was counteracted by the concurrent application of the selective 5-HT1A receptor antagonist WAY-100635. This agent also reversed the decrease in 5-HT output elicited by the novel 5-HT1A receptor agonist BAY x 3702 (30 microM) in mPFC and dorsal raphe nucleus. These results indicate that postsynaptic 5-HT1A receptors in mPFC also participate in the control of serotonergic activity.
Robust stabilizability of linear time-invariant plants (1987)

In this paper, we address the topic of (robust) pointwise stabilizability of families of linear time-invariant (LTI) plants arising from unstructured modeling uncertainty. The results presented here extend some earlier work reported in [9], and show that there is no advantage in using general nonlinear time-varying (NLTV) controllers over LTI ones for certain problems of (robust) pointwise stabilization.
Synthesis of the Tubuvaline-Tubuphenylalanine (Tuv-Tup) Fragment of Tubulysin (2004)

[structure: see text] Advanced intermediates and analogues of tubulysins were prepared in a convergent strategy.
Costs associated with common dual-controller therapies for treating asthma in several managed care populations. (2004)

The cross-sectional study showed that different drug regimens were associated with measurable differences in outcome when both drug costs and use of medical services are taken into account. This stimulated a more rigorous follow-up study controlling for asthma severity by using preindex cost and use measures. The 12-month risk-adjusted total cost for the fluticasone propionate and salmeterol group was the lowest at 975 dollars, followed by 1,089 dollars and 1,268 dollars for the ICS and salmeterol and the ICS and leukotriene modifier groups, respectively. Overall cost per patient of dual-controller therapy consisting of fluticasone propionate and the inhaled long-acting beta2-agonist salmeterol was lower than a regimen consisting of either another inhaled corticosteroid with salmeterol or an inhaled corticosteroid with a leukotriene modifier. The cost of asthma treatment failure (i.e., inpatient and emergency department) was similar between groups.