gebhart/patrepeval huggingface dataset:
Pre-steady-state kinetics of the activation of rabbit skeletal muscle myosin light chain kinase by Ca2+/calmodulin. (1992)

Myosin light chain kinase is activated by Ca2+/calmodulin. Insights into the kinetic mechanism of this activation by Ca2+/calmodulin have now been obtained using extrinsically labeled fluorescent calmodulin, a fluorescent peptide substrate, and a stopped-flow spectrophotofluorimeter. We employed spinach calmodulin labeled with the sulfhydryl-selective probe, 2-(4-maleimidoanilino)naphthalene-6-sulfonic acid, to measure changes in the fluorescence intensity of the 2-(4-maleimidoanilino)naphthalene-6-sulfonic acid-calmodulin upon binding to rabbit skeletal muscle myosin light chain kinase. The fluorescent peptide substrate KKRAARAC(sulfobenzo-furazan)SNVFS-amide was used to measure kinase activity. Our results showed that the binding interaction could be modeled as a two-step process: a bimolecular reaction with an association rate of 4.6 x 10(7) M-1 s-1 followed by an isomerization with a rate of 2.2 s-1. Phosphorylation of the peptide during stopped-flow experiments could be modeled by a two-step process with a catalytic association rate of 6.5 x 10(6) M-1 s-1 and a turnover rate of 10-20 s-1. Our results also indicated that kinase activity occurred too rapidly for the slower isomerization rate of 2.2 s-1 to be linked specifically to the activation process.
Irreversible inhibition of rat glutathione <i>S</i>-transferase 1-1 by quinones and their glutathione conjugates. Structure-activity relationship and mechanism (1991)

The irreversible inhibition of the rat glutathione S-transferase (GST) isoenzyme 1-1 by a series of halogenated 1,4-benzoquinones and their GSH conjugates was studied quantitatively by analysing the time course of enzyme inactivation. With increasing numbers of chlorine substituents, the rate of inhibition greatly increased. Incorporation of a GSH moiety in all cases increased the rate of inactivation compared with the non-substituted compound, and this was due to the increased affinity of the inhibitor for the active site. The ratio between the rates of inhibition for a given quinone with and without GSH substituent was largest for the three dichlorobenzoquinones, with the 2,6-isomer showing a 41-fold increase in rate of inhibition upon conjugation with GSH. The time courses of inhibition could be fitted either to a bi-exponential function (for the GSH conjugates and the higher chlorinated quinones) or to a mono-exponential function (all other quinones). It is concluded that the second component describes the affinity part of the reaction. GST 1-1 possesses two cysteine residues, with modification of one of these, probably located in the vicinity of the active site, having a major impact on the enzyme activity. Compounds with affinity towards the active site preferentially react with this residue. Non-specific quinones react equally with both cysteine residues. This was confirmed by the observation that complete inactivation of GST 1-1 by 2,5-dichlorobenzoquinone was achieved only after modification of two residues, whereas the corresponding GSH conjugate already completely inhibited the enzyme after modification of one residue.
P‐87: Local Dimming Design and Optimization for Edge‐Type LED Backlight Unit (2011)

Abstract As the LCD TV market expands, the demands for a high‐performance, high‐definition image quality and eco‐friendly products are constantly rising. The LED backlight technology is a primary case which satisfies such demands. The LED backlight can be classified as either a direct‐type or an edge‐type according to the arrangement of light sources. The direct‐type has advantage of 2‐dimensional dimming leading to a low power consumption and better image quality whereas edge‐type has advantage in the fancy design, achieving slim thickness. To achieve the slim design and the low power consumption, the edge‐type backlight unit is preferred to direct‐type. A new type of edge backlight structure is proposed with edge local dimming to achieve higher Contrast Ratio (C/R) and low power consumption in addition to the advantage of a slim thickness. A new Light Guide Plate (LGP) structure for edge local dimming was verified and lenticular LGP is proposed to obtain straight line motion of light. In addition, power consumption reduction was achieved though algorithm development. A patterned LGP production method of various concepts was examined to realize 2‐line local dimming. It was reduced 30% power consumption of all energy through 2‐line local dimming structure. And, CR improved with 14,500:1 from 1, 128:1.
THERMAL TEMPERING SIMULATION OF GLASS PLATES: INNER AND EDGE RESIDUAL STRESSES (1998)

Narayanaswamy's model is used to describe the thermomechanical behavior of glass. It includes both stress relaxation (to take into account the viscous aspect of glass) and structural relaxation (to take into account the structure state of glass). The necessary thermal and mechanical characteristics are given for the float soda-lime silicate glass. The thermal tempering of thin glass plates is simulated. Transient and residual stresses are given for the inner part of the plate. Computational results are compared with experimental results of previous works. This comparison validates Naranaswamy's model associated with material characteristics given previously. The edge effect (variation of stresses close to the edges) is described for thin plates. The thermal tempering of thick plates is simulated, and computational results are validated with optical measurements and a fractographic analysis.
Atrial average conduction velocity in patients with and without paroxysmal atrial fibrillation (2016)

Compared to patients with AVNRT, patients with AF are associated with conduction delay in both atria with the delay being more marked in the LA than in the RA, which suggests the involvement of conduction disturbances in the genesis and/or perpetuation of AF.
Analysis for complete genomic sequence of HLA-B and HLA-C alleles in the Chinese Han population (2011)

In the present study, we have determined the complete genomic sequence and analysed the intron polymorphism of partial HLA-B and HLA-C alleles in the Chinese Han population. Over 3.0 kb DNA fragments of HLA-B and HLA-C loci were amplified by polymerase chain reaction from partial 5' untranslated region to 3' noncoding region respectively, and then the amplified products were sequenced. Full-length nucleotide sequences of 14 HLA-B alleles and 10 HLA-C alleles were obtained and have been submitted to GenBank and IMGT/HLA database. Two novel alleles of HLA-B*52:01:01:02 and HLA-B*59:01:01:02 were identified, and the complete genomic sequence of HLA-B*52:01:01:01 was firstly reported. Totally 157 and 167 polymorphism positions were found in the full-length genomic sequence of HLA-B and HLA-C loci respectively. Our results suggested that many single nucleotide polymorphisms existed in the exon and intron regions, and the data can provide useful information for understanding the evolution of HLA-B and HLA-C alleles.
Theory of the Optical Properties of Non-absorbing Compensated Cholesteric Liquid Crystals (1973)

Abstract A theory is developed of the optical properties of a non-absorbing compensated cholesteric liquid crystal. It is shown that the Mauguin—de Vries equation fails when the pitch becomes very large. Theoretical curves are presented of the dependence of the rotatory power on pitch for different values of the sample thickness. The results are in agreement with the observed variation of the rotatory power of a compensated cholesteric mixture with temperature.
Tandem mass spectrometry investigation of ADP-ribosylated kemptide (2008)

Bacterial adenosine diphosphate-ribosyltransferases (ADPRTs) are toxins that play a significant role in pathogenicity by inactivating host proteins through covalent addition of ADP-ribose. In this study we used ADP-ribosylated Kemptide (LRRASLG) as a standard to examine the effectiveness of three common tandem mass spectrometry fragmentation methods for assignment of amino acid sequence and site of modification. Fragmentation mechanisms investigated include low-energy collision-induced dissociation (CID), infrared multiphoton dissociation (IRMPD), and electron-capture dissociation (ECD); all were performed on a hybrid linear ion trap Fourier transform ion cyclotron resonance mass spectrometer. We show that ECD, but neither CID nor IRMPD, of ADP-ribosylated Kemptide produces tandem mass spectra that are interpretable with regard to amino acid sequence assignment and site of modification. Examination of CID and IRMPD tandem mass spectra of ADP-ribosylated Kemptide revealed that fragmentation was primarily focused to the ADP-ribose region, generating several potential diagnostic ions for use in discovery of ADP-ribosylated proteins. Because of the lower relative sensitivity of ECD during data-dependent acquisition to CID, we suggest a 2-fold strategy where CID and IRMPD are first used to detect ADP-ribosylated peptides, followed by sequence assignment and location of modification by ECD analysis.
Evidence for Normal Antidiuretic Responses to Endogenous and Exogenous Arginine Vasopressin in Patients with Guanine Nucleotide-Binding Stimulatory Protein-Deficient Pseudohypoparathyroidism* (1986)

In six patients with pseudohypoparathyroidism (PHP) who were deficient in guanine nucleotide-binding stimulatory protein (Ns) activity, the response to endogenous arginine vasopressin (AVP) was tested during water deprivation. Hourly plasma osmolality (Posm), urinary osmolality (Uosm), and urinary AVP (UAVP) values were compared to those in normal subjects. The Uosm vs. Posm and the UAVP vs. Uosm relationships of the patients were all within the normal range. Four patients with Ns-deficient PHP were subjected to maintained water loads and infused with AVP at three different rates for 1 h each to assess their responses to exogenous AVP. Urinary volume and osmolality values from the final 30 min of each infusion rate were measured. All volume values except 1 were within 1.6 SD of normal, and all osmolality values except 1 were within 1.1 SD of normal. In conclusion, these studies indicate that these six patients with Ns-deficient PHP are not resistant to the antidiuretic (cAMP-mediated) action of endogenous or exogenous AVP, in contrast to the previously documented resistance of patients with Ns-deficient PHP to the actions of PTH, TSH, glucagon, and gonadotropins.
The Relationship between Inflation and Growth (1999)

In the economic literature, the relationship between growth and inflation has been discussed in different ways with respect to the development stages of the world economy. According to the current view, there is a negative relationship between growth and inflation. This seems to be compatible with the fact that the investments and the economic growth has been negatively affected by the high and chronic inflation rates in Turkey in the last 20 years. Thus, improvement of the long-run growth potential depends on the elimination of the uncertainties that stems from high inflation.
Integration Without Compromise (2014)

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Transistor MOS et sa technologie de fabrication (2000)

Le transistor MOS est, de loin, le dispositif le plus répandu dans la production actuelle de composants semi-conducteurs, car il est le composant de base de la technologie CMOS (Complementary MOS), qui, à elle seule, englobe plus de 70 % de la production mondiale de circuits intégrés. Plusieurs sigl
Influence of Calcium Ions on Cell Survival and Proliferation in the Context of an Alginate Hydrogel (2012)

One goal of biofabrication is to incorporate living cells into artificial scaffolds in order to repair damaged tissues or organs. Although there are many studies on various biofabrication techniques, the maintenance of cell viability during the biofabrication process and cell proliferation after the process is still a challenging issue. Construction of scaffolds using hydrogels composed of natural materials can avoid exposure of cells to harsh chemicals or temperature extremes but can still entail exposure to non-physiological conditions, causing cell damage or even death. This paper presents an experimental investigation into the influence on Schwann cell survival and proliferation of calcium used for ionic crosslinking of alginate hydrogel during the biofabrication process. The experimental results obtained show the viability and proliferation capacity of cells, either suspended in cell culture medium or encapsulated in hydrogel, and vary with the calcium concentration and the time period of cells exposed to the calcium environment. The experimental results also show the alginate concentration and cell density, that have profound influence on cell survival and proliferation, and solution viscosity as well. This study suggests the incorporation of living cells in calcium-crosslinked hydrogel in the biofabrication process can be regulated for controlled cell survival and proliferation.
Biliary lithotripsy: 1989 (1989)

+ Affiliation: Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
Women and the Notion of Propriety in the French Theatre (1628-1643) (1975)

Journal Article WOMEN AND THE NOTION OF PROPRIETY IN THE FRENCH THEATRE (1628–1643) Get access WENDY GIBSON WENDY GIBSON Reading Search for other works by this author on: Oxford Academic Google Scholar Forum for Modern Language Studies, Volume XI, Issue 1, January 1975, Pages 1–14, https://doi.org/10.1093/fmls/XI.1.1 Published: 01 January 1975
A skin-inspired tactile sensor for smart prosthetics (2018)

Recent achievements in the field of electronic skin have provided promising technology for prosthetic systems. However, the development of a bionic tactile-perception system that exhibits integrated stimuli sensing and neuron-like information-processing functionalities in a low-pressure regime remains a challenge. Here, we demonstrate a tactile sensor for smart prosthetics based on giant magneto-impedance (GMI) material embedded with an air gap. The sensor exhibits a high sensitivity of 120 newton<sup>-1</sup> (or 4.4 kilopascal<sup>-1</sup>) and a very low detection limit of 10 micronewtons (or 0.3 pascals). The integration of the tactile sensor with an inductance-capacitance (LC) oscillation circuit enabled direct transduction of force stimuli into digital-frequency signals. The frequency increased with the force stimuli, consistent with the relationship between stimuli and human responses. The minimum loading of 50 micronewtons (or 1.25 pascals), which is less than the sensing threshold value of human skin, was also encoded into the frequency, similar to the pulse waveform of humans. The proposed tactile sensor not only showed desirable sensitivity and low detection limit but also exhibited transduction of digital-frequency signals like human stimuli responses. These features of the GMI-based tactile sensor show potential for its applications in smart prosthetics, especially prosthetic limbs that can functionally replace natural limbs.
False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward (2016)

We highlight a significant problem that needs to be considered and addressed when performing functional near-infrared spectroscopy (fNIRS) studies, namely the possibility of inadvertently measuring fNIRS hemodynamic responses that are not due to neurovascular coupling. These can be misinterpreted as brain activity, i.e., "false positives" (errors caused by wrongly assigning a detected hemodynamic response to functional brain activity), or mask brain activity, i.e., "false negatives" (errors caused by wrongly assigning a not observed hemodynamic response in the presence of functional brain activity). Here, we summarize the possible physiological origins of these issues and suggest ways to avoid and remove them.
Adhesion molecules in experimental phacoanaphylactic endophthalmitis. (1992)

Intraocular accumulation of inflammatory neutrophils is an important feature of experimental phacoanaphylactic endophthalmitis (EPE). Increasing evidence suggests that localization of neutrophils to the site of inflammation requires the participation of neutrophil and endothelial adhesion molecules. These studies were undertaken to determine if blocking of adhesion molecules on neutrophils (CD18) or endothelium (ELAM-1) could attenuate EPE in Lewis rats. Treatment of experimental animals with anti-CD18 or anti-ELAM-1 significantly suppressed intraocular neutrophil accumulation, retinal hemorrhage, and vasculitis, and attenuated retinal edema formation by 48% and 70%, respectively. These observations demonstrate that antibodies directed against adhesion molecules on the neutrophil (CD18) or the vascular endothelial cell (ELAM-1) exhibit potent anti-inflammatory effects, resulting in a striking amelioration of injury in EPE in rats.
Microsoft Office Word 2003 Inside Out (2003)

From the Publisher

Hey, you know your way around Microsoft Wordso now dig into Word 2003 and really put your documents to work! This supremely organized reference packs all the information you need to master every major tool, task, and enhancement in Word 2003without the fluff. Work smarter with core functions such as creating and formatting documents; creating visual effects; producing tables and charts; developing custom forms; and writing macros with Microsoft Visual Basic® for Applications (VBA). Quickly advance your expertise with XML capabilities in Word, support for the Tablet PC, new document workspaces, and more. Youll gain hundreds of timesaving solutions, troubleshooting tips, and handy workarounds in concise, fast-answer format. Plus, you get the Office Productivity Kit on CD-ROMfeaturing a complete eBook, author extras, bonus content, the Microsoft Computer Dictionary, Fifth Edition, and dozens of other resources. With INSIDE OUT, youll discover the best and fastest ways to perform everyday tasksand challenge yourself to new levels of Word mastery!
Informe, ¿salidas rápidas o lentas?: etrategias del ritmo de carrera (2003)

Adipose tissue plays an active role in the development of obesity, and thus characterization of the molecular changes related to obesity in this tissue is a priority. Recently, we identified tungstate as a potent body weight reducing agent in obese animals, adipose tissue being one of the targets of its action. In this study a proteomics approach combining 2-DE and MS was used to identify proteins associated with obesity and targets of tungstate in white adipose tissue. Twenty-nine proteins were found differentially expressed between lean and diet-induced obese rats. Expression changes in transferrin, vimentin, vinculin, peroxiredoxins, Rho-GTP dissociation inhibitor, grifin, guanine deaminase and 3-phosphoglycerate dehydrogenase were associated here for the first time with obesity. Furthermore, tungstate treatment of obese rats reverted expression changes of 70% of the proteins modulated by obesity and another ten proteins were regulated by tungstate independently of the body weight reduction. The results suggest that the tungstate antiobesity effect can be mediated by the modulation of cellular structure, metabolism, redox state and signalling processes in adipose tissue. These findings open new avenues for the study of the aetiology of obesity and its treatment.
Analysis of illicit ecstasy tablets: implications for clinical management in the accident and emergency department. (1999)

These results have implications for emergency workers attending to those who have become casualties of the drug ecstasy. Those claiming to have ingested ecstasy may actually have taken other agents that require different clinical management.
WSFRB protocol and virtual program computing (2005)

To enable single program be shared by multi collaborating users in the virtual network computing environment, this paper proposed a new concept of virtual program computing, that is, a single program is running in the remote computer and the graphical user interface of this program is displayed in the local computer, and also, the program accept the keyboard and mouse input from the local computer. To realize the virtual program computing, we proposed a new protocol called WSFRB protocol (windows size within remote frame buffer protocol) based on virtual network computing. The WSFRB protocol clips the size of remote frame buffer by using the window size and position of the running program in remote server. Therefore the data transmitted in the network can be reduced greatly compare to FRB protocol. The application of the WSFRB protocol and virtual program computing in the NMS integration systems are investigated in detail. Experiments and application have demonstrated that the virtual program computing offered a great flexibility in creating a new collaborating computing environment.
Atomic force microscopy study of the faceting on MgO(110) surface (1998)

Using atomic force microscopy, we have studied the morphologies of the MgO(110) surface. After annealing at 650 °C, this surface facets into elongated triangular mesoscale islands along the [001] direction. A statistical counting of both the widths and the heights of these islands can be well fitted by a Gaussian normal distribution. The most popular island width and height are ∼1200 and 140 Å, respectively, indicating that these faces are roughly (350). The formation of (350) plans, instead of (100), is believed due to a kinetic reason. Besides, both Gaussian distributions are much narrower than predicted for the microscopic terrace-step-kink model. This result may suggest that an island–island interaction is fundamentally different from a step–step interaction.
Restriction site mutation analysis, a proposed methodology for the detection and study of DNA base changes following mutagen exposure (1990)

We propose a methodology for the detection of DNA base changes in restriction enzyme recognition sites. The restriction site mutation (RSM) technique is based upon the detection of DNA sequences resistant to the cutting action of specific restriction enzymes and the amplification of these resistant sequences using the polymerase chain reaction. As outlined, the RSM method has the potential for use in the study of induced base changes in any species, tissue and genes of known DNA sequence for which unique DNA primers are available, and which contains a number of unique restriction enzyme recognition sites.
The Promise of Private Pensions: The First Hundred Years (1997)

The private pension is a curiosity in the modern economic environment. Why do profit-seeking companies pay retirement benefits to those no longer on the job? In this new institutional history, Steven Sass explores the rise and growth of the financial support system that today commands trillions of dollars of investment capital and supports millions of older Americans. As Sass shows, creating the pension system proved far more complicated than anyone had anticipated. Over the last hundred years it has evolved into a complex institution driven by congressional mandates, judicial/administrative decisions, union campaigns, political debates, and the ministrations of lawyers, economists, human resource specialists, actuaries, and insurance experts. Sass traces the U.S. pension system through to the present day, exploring how our modern corporate economy is confronting the challenges of an aging population.