gebhart/patrepeval huggingface dataset:
High-flux hemodiafiltration: under six hours/week treatment. (1984)

Better utilization of existing high blood flow in mature vascular accesses with the described new technique of simultaneous high diffusion and convection results in a marked increase of treatment efficiency. Coupled with the better tolerance to high solute and weight removal rates, this approach permits drastic reduction of treatment time over conventional hemodialysis without sacrificing treatment adequacy.
Oogenesis in <i>Xenopus laevis</i> (Daudin) VI. The route of injected tracer transport in the follicle and developing oocyte, (1978)

Abstract In Xenopus laevis, vitellogenin (the yolk precursor) is synthesized in the liver and transported via the circulatory system to the ovary. In order to reach developing oocytes where it is sequestered, it must exit the circulatory system and traverse several follicular tissue layers including the theca, the follicle cell layer, and the vitelline envelope. This study demonstrates this pathway by means of electron‐opaque tracers, and follows the fate of heterologous macromolecules after their incorporation into the ooplasm. The tracers used were horseradish peroxidase, iron dextran, ferritin, and thorotrast. The bulk of the tracers exit the circulatory system through gaps between adjacent capillary endothelial cells and migrate into the connective tissue theca, where they appear randomly dispersed. All tracers, except thorotrast, penetrate the basement membrane on the distal surface of the follicle cells and pass through channels between adjacent follicle cells into the vitelline envelope and to the surface of developing oocytes, where they are incorporated by endocytosis. Endosomes which contain tracer, and also presumably vitellogenin, fuse to form primordial yolk platelets. During this fusion process an extensive network of smooth‐surfaced tubules arises in the peripheral ooplasm. Endosomes and/or primordial yolk platelets continue to fuse with each other, resulting in the growth of primordial platelets which move deeper into the ooplasm, where they are transformed into yolk platelets with crystalline main bodies. Peroxidase and iron dextran remain in the superficial layer of the platelet, while ferritin is present in both the superficial layer and the crystalline main body.
An overview of IEEE 802.12 demand priority (2002)

Demand priority is the media access control protocol used by the new 100 Mb/s 100 VG-AnyLAN network being standardised by the IEEE 802.12 committee. The network can interconnect hubs in multiple wiring closets (without bridging or routing), and can have a network diameter of several kilometers. The network is the only 100 Mb/s technology to support Category 3 cabling including bundled cables, which are found at many user's installations. Demand priority supports two priority levels, and this will enable it to effectively support real time multimedia applications. A further advantage of IEEE 802.12 demand priority is that it supports IEEE 802.3 and IEEE 802.5 frame formats, thus allowing users to evolve from the currently prevalent 802.3 and 802.5 networks without having to load new software. This paper describes demand priority, and compares it with other high speed local area network technologies.
MC‐38 adenocarcinoma tumor infiltrating lymphocytes: Correlation of cytotoxicity with time of tumor harvest after tumor inoculation (1990)

Tumor infiltrating lymphocytes (TILs) are capable of mediating significant tumor regressions in vitro and in vivo in animal systems. In humans, however, many TIL cell lines are not cytotoxic in vitro, and clinical trials thus far have been less than encouraging. We attempted to correlate TIL cytotoxicity with time of tumor harvest and TIL cell surface antigenic expression. TILs harvested from early MC-38 adenocarcinoma tumors (days 9 and 20 post-tumor implantation), demonstrated significantly higher cytotoxicity against a variety of tumor targets compared to older TILs (days 31 and 37). The younger TILs had a higher expression of the Lyt-1 (Helper T cells), asialo GM1 (NK and T cells), and 49H.8 (NK cells) antigens. Comparison with the MCA-102 sarcoma, a tumor that does not lead to cytotoxic TILs, revealed a low expression of the Lyt-1 antigen on their cell surface. We conclude that TILs cytotoxicity is time-dependent and may be dependent on the presence of Lyt-1+ cells in the overall TIL population of cells.
Distribution of the murine plasma cell antigen PC-1 in non-lymphoid tissues. (1988)

PC-1 is an alloantigen of murine plasma cells. Its close association with secretory function in lymphoid cells previously raised the question of whether PC-1 was part of the secretory apparatus. In addition to its expression on lymphocytes, PC-1 had been known to be present in liver, brain, and kidney, although the data were derived almost entirely from bulk absorption studies of polyclonal alloantisera, and virtually nothing was known about the nature of the cells expressing PC-1 in these organs. If PC-1 was functionally involved in the secretory process. it might be expected to be present at secretory sites within these and other organs. We now report the results of an immunohistochemical survey of the distribution of PC-1 in a variety of non-lymphoid organs, using a mAb. The PC-1 Ag was found in a small number of highly discrete locations that were mostly, but not exclusively, associated with epithelia. Sites of strong expression included the distal convoluted tubule of the kidney, ducts of the salivary glands, epididymis, proximal part of the vas deferens, and chondrocytes. The PC-1 glycoprotein was also found in the capillaries of the brain, but did not appear to be present in capillaries elsewhere, a pattern that is strikingly similar to that of the receptor for the iron transport protein, transferrin. Negative sites included the thyroid, pancreas, choroid plexus, smooth and striated muscle, stomach, small and large intestine, gall bladder, renal glomeruli, testis, and seminal vesicles. These results are not consistent with a generalized role for PC-1 in secretion, but are compatible with a role in a specialized subset of macromolecular transport events.
Molecular characterisation of the tick Rhipicephalus microplus in Malaysia: new insights into the cryptic diversity and distinct genetic assemblages throughout the world (2015)

We conclude that the R. microplus complex consisting of at least five taxa: R. australis, R. annulatus, R. microplus clade A sensu Burger et al. (2014), R. microplus clade B sensu Burger et al. (2014) and the new taxon, R. microplus clade C sensu Low et al. (2015). The use of COI as the standard genetic marker in discerning the genetic assemblages of R. microplus from a broad range of biogeographical regions is proposed.
Information-seeking on the Web with Trusted Social Networks - from Theory to Systems (2008)

This research investigates how synergies between the Web and social networks can enhance the process of obtaining relevant and trustworthy information. A review of literature on personalised search, social search, recommender systems, social networks and trust propagation reveals limitations of existing technology in areas such as relevance, collaboration, task-adaptivity and trust. In response to these limitations I present a Web-based approach to information-seeking using social networks. This approach takes a source-centric perspective on the information-seeking process, aiming to identify trustworthy sources of relevant information from within the user's social network. An empirical study of source-selection decisions in information- and recommendation-seeking identified five factors that influence the choice of source, and its perceived trustworthiness. The priority given to each of these factors was found to vary according to the criticality and subjectivity of the task. A series of algorithms have been developed that operationalise three of these factors (expertise, experience, affinity) and generate from various data sources a number of trust metrics for use in social network-based information seeking. The most significant of these data sources is Revyu.com, a reviewing and rating Web site implemented as part of this research, that takes input from regular users and makes it available on the Semantic Web for easy re-use by the implemented algorithms. Output of the algorithms is used in Hoonoh.com, a Semantic Web-based system that has been developed to support users in identifying relevant and trustworthy information sources within their social networks. Evaluation of this system's ability to predict source selections showed more promising results for the experience factor than for expertise or affinity. This may be attributed to the greater demands these two factors place in terms of input data. Limitations of the work and opportunities for future research are discussed.
Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver (2012)

The results indicate that LSECtin plays an important role in colorectal carcinoma liver metastasis and may be a promising new target for intervention in metastasis formation.
Evaluation of Naïve Bayes and Support Vector Machines on Bangla Textual Movie Reviews (2018)

The ever-growing World Wide Web (WWW) containing textual movie reviews from Facebook groups, personal blogs, newspapers, dedicated movie review sites has crucial impacts on intended users and review providers where users can find the desired movies in his preference by checking the reviews and review providers can build a better recommendation system that influences the marketing policy and revenues generated from advertising campaigns. The manual approach to analyze this textual reviews is complex and time-consuming and hence it requires specialized automated systems. Sentiment Analysis (SA) is such a tool which is the computational study of extracting opinions, emotions from textual data to build such automated systems and it has been implemented in many languages for movie review domain except Bangla; which is continuously increasing due to the emergence of Bangladeshi reviewers on WWW. Since none of the existing SA works addressed this domain, in this paper, we have developed a polarity detection system on textual movie reviews in Bangla by using two popular machine learning algorithms named Naive Bayes (NB) and Support Vector Machines (SVM) and provided a comparative results where SVM performed slightly better than NB by considering stemmed unigram as feature with an excellent precision of 0.86.
A new error model for adaptive systems (1980)

A simple error model is described for both discrete and continuous time adaptive systems. The stability of the model for both bounded and unbounded inputs is analyzed for the discrete case and extended to continuous time models. It is shown that <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\Delta\phi(k)\in I^{2}</tex> in the former case and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\phi(t)\in L^{2}</tex> in the latter case due to the presence of a feedback signal and these in turn play an important role in the stability analysis of discrete and continuous time adaptive systems.
Hybrid techniques for real-time radar simulation (1963)

This paper summarizes results of a study of the design and application of special-purpose computers for the simulation of air-to-ground radars. Specifically, the computers must generate information in real-time to simulate the display of a scanning radar in a vehicle flying at Mach 3 and arbitrary altitude. The radar can view 105 square miles of terrain per second with a resolution of 60 points per mile in range (five per microsecond). This paper describes a hybrid simulator that exploits both the redundancy in the terrain and the repetitiveness caused by the radar scan pattern. An overall design is presented that affords reductions of 103 in storage capacity and computation speed, compared with a straightforward digital approach for generation of topographic profiles from which the display is prepared. Details are presented of data formats and transfer schemes through the memory hierarchy, and of algorithms for the reconstruction of analog profiles from a digitally stored contour map.
Carbon Nanotube Synthesis and Growth Mechanism (2011)

A carbon nanotube (CNT) is a tubular structure made of carbon atoms, having diameter of nanometer order but length in micrometers. Right from its discovery, we have been listening exciting quotations about CNT, viz. “CNT is 100 times stronger than stainless steel and six times lighter...” “CNT is as hard as diamond and its thermal capacity is twice that of pure diamond...” “CNT’s current-carrying capacity is 1000 times higher than that of copper...” “CNT is thermally stable up to 4000K...” “CNT can be metallic or semiconducting, depending on their diameter and chirality...” However, it is important to note that all those superlative properties were predicted for an atomically-perfect ideal CNT which is far from the CNTs we are practically producing today. Despite a huge progress in CNT research over the years, we are still unable to produce CNTs of well-defined properties in large quantities by a cost-effective technique. The root of this problem is the lack of proper understanding of the CNT growth mechanism. There are several questions at the growth level awaiting concrete answer. Till date no CNT growth model could be robustly established. Hence this chapter is devoted to review the present state of CNT synthesis and growth mechanism. There are three commonly-used methods of CNT synthesis. Arc-discharge method, in which the first CNT was discovered, employs evaporation of graphite electrodes in electric arcs that involve very high (~4000°C) temperatures (Iijima, 1991). Although arc-grown CNTs are well crystallized, they are highly impure; about 60–70% of the arc-grown product contains metal particles and amorphous carbon. Laser-vaporization technique employs evaporation of high-purity graphite target by high-power lasers in conjunction with high-temperature furnaces (Thess et al., 1996). Although laser-grown CNTs are of high purity, their production yield is very low (in milli gram order). Thus, it is obvious that these two methods score too low on account of efficient use of energy and resources. Chemical vapor deposition (CVD), incorporating catalyst-assisted thermal decomposition of hydrocarbons, is the most popular method of producing CNTs; and it is truly a low-cost and scalable technique for mass production of CNTs (Cassell et al., 1999). That is why CVD is the most popular method of producing CNTs nowadays. Here we will review the materials aspects of CNT synthesis by CVD and discuss the CNT growth mechanism in the light of latest progresses in the field.
Microsatellite diversity, pedigree relatedness and the contributions of founder lineages to thoroughbred horses (2001)

The thoroughbred (TB) horse is one of the oldest breeds of domestic animals, with pedigree records spanning three centuries. Because the population is essentially closed, there is concern about loss of genetic variation. Here we report two parallel analyses. In the first, genetic variation in the current population is measured using data from 13 microsatellite loci in 211 horses with relationships calculated based on allele sharing. In the second analysis, pedigree information is used to calculate genetic relationships between animals based on shared ancestry. These two measures of relationship are compared and shown to be closely related. Together, they provide an estimate of the amount of genetic variation which existed in founder animals. This study confirms the narrow genetic base of the breed and provides comprehensive analysis of contributions of founder animals. Seventy-eight percent of alleles in the current population are derived from 30 founders, 27 of these male. Ten founder females account for 72% of maternal lineages, while one founder stallion is responsible for 95% of paternal lineages.
Advances in ultrasound techniques and instrumentation (1993)

Display and perception of ultrasound images probes as used in cardiology with emphasis on transesophageal and intravascular applications ultrasound contrast agents advances in imaging techniques speckle reduction three-dimensional imaging needle guidance techniques techniques for colour-flow imaging ultimate limits in ultrasound image resolution blood flow quantitation - waveform analysis, volume measurement, tumour flow and the role of colour imaging ultrasound picture archiving and communication systems impact of safety considerations on ultrasound equipment and use quality management of ultrasound diagnosis.
The value of day surgery (1993)

Diane Coleman describes a research study aimed at finding out whether children are more distressed if admitted to hospital the day before routine surgery, rather than on the day itself
Utilities for High-Throughput Analysis of B-Cell Clonal Lineages (2015)

There are at present few tools available to assist with the determination and analysis of B-cell lineage trees from next-generation sequencing data. Here we present two utilities that support automated large-scale analysis and the creation of publication-quality results. The tools are available on the web and are also available for download so that they can be integrated into an automated pipeline. Critically, and in contrast to previously published tools, these utilities can be used with any suitable phylogenetic inference method and with any antibody germline library and hence are species-independent.
The XXth century dengue pandemic: need for surveillance and research. (1992)

By the last decade of the XXth century Aedes aegypti and the 4 dengue viruses had spread to nearly all countries of the tropical world. Some 2 billion persons live in dengue-endemic areas with tens of millions infected annually. Dengue pandemics were also documented in the XVIIIth and XIXth centuries; they were contained by organized anti-Aedes aegypti campaigns and urban improvements. The XXth century dengue pandemic has brought with it the simultaneous circulation of multiple serotypes and in its aftermath, endemic dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). Nearly 3 million children have been hospitalized with this syndrome in the past 3 decades, mainly in South-East Asia. Recent outbreaks of DHF/DSS in the Pacific Islands, China, India, Sri Lanka, Cuba and Venezuela are indicators of the high intensity and rapid spread of dengue transmission. The magnitude of the XXth century dengue pandemic requires urgent improvements in early warning surveillance by WHO Member States and the development of the capacity to study underlying mechanisms of the disease. A key research question is why does DHF/DSS not occur with all second dengue infections? Two answers have been suggested: (1) a human resistance gene. Data from the 1981 DHF/DSS epidemic in Cuba have demonstrated the existence in blacks of a resistance gene. The effect of such a gene in reducing disease susceptibility of American and African blacks requires more study. (2) The existence of dengue "biotypes". Some, but not all biotypes may cause DHF/DSS during a second dengue infection.(ABSTRACT TRUNCATED AT 250 WORDS)
Nerve Conduits for Nerve Repair or Reconstruction (2012)

Advances in treating peripheral nerve lesions have resulted from research in nerve regeneration and the use biomaterials as well as synthetic materials. When direct tensionless repair of peripheral nerve lesions is not possible, nerve conduits may be used to bridge digital sensory nerve gaps of ≤3 cm. Nerve autograft is the benchmark for larger, longer, mixed, or motor nerve defects. Biologic, autogenous conduits-typically veins or, rarely, arteries-have demonstrated their utility in nerve gaps <3 cm in length. Three types of bioabsorbable conduit have been approved by the US Food and Drug Administration, constructed of collagen, polyglycolic acid, or caprolactone. Caprolactone conduits have been found to be equivalent in results to autograft. Collagen conduits are next best, and polyglycolic acid conduits are functionally inferior. Further research and prospective, multicenter, large-scale trials are needed to help establish the role of synthetic, bioabsorbable conduits in peripheral nerve reconstruction.
Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors (2012)

Certain types of nonpsychoactive cannabinoids can potentiate glycine receptors (GlyRs), an important target for nociceptive regulation at the spinal level. However, little is known about the potential and mechanism of glycinergic cannabinoids for chronic pain treatment. We report that systemic and intrathecal administration of cannabidiol (CBD), a major nonpsychoactive component of marijuana, and its modified derivatives significantly suppress chronic inflammatory and neuropathic pain without causing apparent analgesic tolerance in rodents. The cannabinoids significantly potentiate glycine currents in dorsal horn neurons in rat spinal cord slices. The analgesic potency of 11 structurally similar cannabinoids is positively correlated with cannabinoid potentiation of the α3 GlyRs. In contrast, the cannabinoid analgesia is neither correlated with their binding affinity for CB1 and CB2 receptors nor with their psychoactive side effects. NMR analysis reveals a direct interaction between CBD and S296 in the third transmembrane domain of purified α3 GlyR. The cannabinoid-induced analgesic effect is absent in mice lacking the α3 GlyRs. Our findings suggest that the α3 GlyRs mediate glycinergic cannabinoid-induced suppression of chronic pain. These cannabinoids may represent a novel class of therapeutic agents for the treatment of chronic pain and other diseases involving GlyR dysfunction.
Spatial structure of low-frequency wind noise (2007)

The distinguishing spatial properties of low-frequency microphone wind noise (turbulent pressure disturbances) are examined with a planar, 49-element array. Individual, propagating transient pressure disturbances are imaged by wavelet processing to the array data. Within a given frequency range, the wind disturbances are much smaller and less spatially coherent than sound waves. Conventional array processing techniques are particularly sensitive to wind noise when sensor separations are small compared to the acoustic wavelengths of interest.
ACaaS: Access Control as a Service for IaaS Cloud (2013)

Organizations and enterprises have been outsourcing their computation, storage, and workflows to Infrastructure-as-a-Service (IaaS) based cloud platforms. The heterogeneity and high diversity of IaaS cloud environment demand a comprehensive and fine-grained access control mechanism, in order to meet dynamic, extensible, and highly configurable security requirements of these cloud consumers. However, existing security mechanisms provided by IaaS cloud providers do not satisfy these requirements. To address such an emergent demand, we propose a new cloud service called access control as a service (ACaaS), a service-oriented architecture in cloud to support multiple access control models, with the spirit of plug gable access control modules in modern operating systems. As a proof-of-concept reference prototype, we design and implement ACaaS_RBAC to provide role-based access control (RBAC) for Amazon Web Services (AWS), where cloud customers can easily integrate the service into enterprise applications in order to extend RBAC policy enforcement in AWS.
Erratum: Linear Theory and Operational Research in British Transport (1961)

"Erratum: Linear Theory and Operational Research in British Transport." Journal of the Operational Research Society, 12(4), p. 294
Oxidative Stress and Antioxidants in the Risk of Osteoporosis — Role of the Antioxidants Lycopene and Polyphenols (2013)

Oxidative Stress and Antioxidants in the Risk of Osteoporosis — Role of the Antioxidants Lycopene and Polyphenols