gebhart/patrepeval huggingface dataset:
PUP MORTALITY AND EVIDENCE FOR PATHOGEN EXPOSURE IN GALAPAGOS SEA LIONS (<i>ZALOPHUS WOLLEBAEKI</i>) ON SAN CRISTOBAL ISLAND, GALAPAGOS, ECUADOR (2017)

The Galapagos sea lion ( Zalophus wollebaeki ), an endangered species, experiences high pup mortality (up to 100%) in years when El Niño events reduce food supply in the Galapagos Islands. Mortality of pups in non-El Niño years is estimated to be 5% in undisturbed colonies. From 2009 to 2012 we observed high pup mortality (up to 67%) in colonies close to the Galapagos capital, Puerto Baquerizo Moreno, where contact with humans, domestic animals, and rats is frequent. Gross postmortem findings from 54 pups included hemorrhagic lesions in liver and congestion in lungs; histopathology suggested a possible association with infectious diseases. Evidence of Leptospira infection was found in five out of seven samples collected in 2010. Canine distemper viral (CDV) RNA was detected in tissues from six sea lions (in 2011-12), four of which were confirmed by nucleotide sequencing. The absence of CDV antibodies in 109 juvenile animals tested in 2014 at urban and remote colonies could indicate that the CDV infection observed in 2011 was likely confined to a few animals. Our results indicated that Galapagos sea lions have been exposed at least to two pathogens, Leptospira and CDV; however, the impact of these infections on the sea lions is unclear.
COMPARATIVE STUDY OF MAGNETIC BEHAVIOR OF <font>RuSr</font><sub>2</sub><font>RE</font><sub>1.5</sub><font>Ce</font><sub>0.5</sub><font>Cu</font><sub>2</sub><font>O</font><sub>10-δ</sub> WHERE <font>RE</font> = <font>Eu</font> AND <font>Sm</font> (2009)

Systematic investigation of structural, magnetic and transport properties of RuSr 2 RE 2-x Ce x Cu 2 O 10 with RE being Sm and Eu has been performed. We present the experimental evidence that the synthesis of RuSr 2 Eu 1.5 Ce 0.5 Cu 2 O 10 under non-optimised heat treatment conditions may results in the formation of secondary RuSr 2 EuCu 2 O 8 phase. In contrast, similar preparation conditions for RuSr 2 Sm 1.5 Ce 0.5 Cu 2 O 10 samples lead to the pure phase. Consequently, RuSr 2 Eu 1.5 Ce 0.5 Cu 2 O 10 samples exhibit a small peak around 125 K in the temperature dependence of dc magnetization, pronounced irreversibility between zero-field cooled and field cooled curves at temperatures higher than the peak temperature, and the bell shaped behavior of the coercive field as the function of temperature above Curie's temperature. These anomalous features, which may arise due to the superposition effect of the main and secondary phases, which are both magnetic, are completely absent for RuSr 2 Sm 1.5 Ce 0.5 Cu 2 O 10 sample, which does not consist of the secondary phase.
Construction and Characterization of Kilobasepair Densely Labeled Peptide-DNA (2014)

Directed assembly of biocompatible materials benefits from modular building blocks in which structural organization is independent of introduced functional modifications. For soft materials, such modifications have been limited. Here, long DNA is successfully functionalized with dense decoration by peptides. Following introduction of alkyne-modified nucleotides into kilobasepair DNA, measurements of persistence length show that DNA mechanics are unaltered by the dense incorporation of alkynes (∼1 alkyne/2 bp) and after click-chemistry attachment of a tunable density of peptides. Proteolytic cleavage of densely tethered peptides (∼1 peptide/3 bp) demonstrates addressability of the functional groups, showing that this accessible approach to creating hybrid structures can maintain orthogonality between backbone mechanics and overlaid function. The synthesis and characterization of these hybrid constructs establishes the groundwork for their implementation in future applications, such as building blocks in modular approaches to a range of problems in synthetic biology.
Maximizing your Opportunities in a Competitive Job Market (2002)

Welcome to the ninth annual Human Factors and Ergonomics Society Career Panel. The job market in our industry has changed significantly over the last year and the questions addressed by this year's panel speak to the issues that exist in a difficult job market. This year, the panel answered four questions to help readers prepare for a career in Human Factors and Ergonomics (HF/E), particularly in light of the current economic climate. During the HFES meeting panel session, the panel will focus on questions from the audience.
Subthreshold leakage current: challenges and solutions (2003)

As technology scales deeper into the nanometer regime, leakage Power is one of the main obstacles to Moore's law. This paper provides an overview of leakage current highlighting its major mechanisms. Subthreshold leakage current becomes the major focus of this paper, outlining how it is impacted by technology scaling. The major techniques used to manage leakage current in industry are then addressed.
Multiple factors underlying the maximum motility of Escherichia coli as cultures enter post-exponential growth (1993)

Motility and chemotaxis allow cells to move away from stressful microenvironments. Motility of Escherichia coli in batch cultures, as measured by cell swimming speed, was low in early-exponential-phase cells, peaked as the cells entered post-exponential phase, and declined into early stationary phase. Transcription from the flhB operon and synthesis of flagellin protein similarly peaked in late exponential and early post-exponential phases, respectively. The increase in swimming speed between early-exponential and post-exponential phases was correlated with twofold increases in both flagellar length and flagellar density per cell volume. This increased investment in flagella probably reflects the increased adaptive value of motility in less favorable environments. The decrease in speed between post-exponential and stationary phases was correlated with a threefold decrease in torque produced by the flagellar motors and presumably reflects decreased proton motive force available to stationary-phase cells.
Gel Chromatographic Amd Electrophoretic Evidence For The Existence Of Soluble 125-I Fibrinogen-131-I-Fibrin-Des AA (AABB) Complexes In Plasma Containing Ca++ At 37°C (1981)

Material and methods: Ca++-boosted (2.5 nmol) protrombin adsorbed plasma (=Ca++-plasma) was prepared by adsorbing thrice with Ba(SO4)2 and dialysing against Ca++-containing Ringer-solution. Ca++-plasma showed negligible thrombin generation as evidenced by Fibrinopeptide A apparance (RIA-FPA), even when continously chromatographed at 20°C for 48h (FPA <15 ng/ml). Plasma containing 125-I fibrinogen and/or 131-I-fibrin Des AA (or Des AABB) monomers (Brosstad et al, Hemostasis 6,225,1977) was subjected to either gel chromato-graphy or to enzyme-fixation. Gel chromatography at 37°C was performed on Sepharose CL-6B, freeze-dried, reconstituted in Ca++-plasma, and developed with Ca++-plasma or Ca++- plasma with EDTA Enzyme-fixation was done by adding thrombin-activated (removable, insolubilized thrombin) Factor XIII (XIIIX). Subsequently XIIIX- activity was quenched with EDTA Enzyme-fixed, radiolabelled complexes were either harvested by thrombin-clotting in the presence of EDTA or chromatographed on Sepharose CL-6B (0.15 M Tris-HCl pH 7.0, 0.15 M NaCl, 2.5 M urea, 10mmol EDTA). Harvested clots were mer-captolysed and SDS-gel electrophoresed. Gel chronatographed specimens were radioprofiled and freeze-dried. Results: In Ca++-plasma both Des AA and Des AABB 131-I fibrin eluted in front of the 125-I fibrinogen, whereas in the presence of EDTA 131-I fibrin Des AA eluted ocnpletely within the 125-I fibrinogen peak. SDS-gel elec trophoresed, mercaptolysed, clots, containing enzyme-fixed,radiolabelled, fibrinogen derivatives,demonstrated 125-I and 131-I activity in γ-γ-dimers and to lesser extent in α-oligemers. Gel chromatographed, enzyme-fixed specimens, demonstrated radiolabelled dimerized fibrinogen derivatives (125-I and 131-I activity) . RIA-FPA of such dimers demonstrated approx. 2 moles FPA/mol dimer. Conclusion: Soluble,covalently-linkable largely dimeric fibrinogen fibrin cenplexes exist in Ca++-plasma at 37°C.
Algorithms for self-reconfiguring molecule motion planning (2002)

In this paper we present algorithms for planning the motion of robotic "molecules" (modules) on a substrate of other molecules. Our approach is to divide self-reconfiguration planning into three levels: trajectory planning, configuration planning, and task-level planning. This paper focuses on algorithms for trajectory planning, moving a single molecule from a start location to a goal location, and configuration planning, moving a set of molecules from a starting configuration to a goal configuration. We also present our scaffold planning approach in which the interior of a structure contains three-dimensional tunnels. This allows molecules to move within a structure as well as on the surface, simplifying molecule motion planning as well as increasing parallelism. In addition, we present a new gripper-type connection mechanism for the molecule which does not require power to maintain connections.
Indications for a Novel Muscular Dystrophy Pathway (2000)

gamma-Filamin, also called ABP-L, is a filamin isoform that is specifically expressed in striated muscles, where it is predominantly localized in myofibrillar Z-discs. A minor fraction of the protein shows subsarcolemmal localization. Although gamma-filamin has the same overall structure as the two other known isoforms, it is the only isoform that carries a unique insertion in its immunoglobulin (Ig)-like domain 20. Sequencing of the genomic region encoding this part of the molecule shows that this insert is encoded by an extra exon. Transient transfections of the insert-bearing domain in skeletal muscle cells and cardiomyocytes show that this single domain is sufficient for targeting to developing and mature Z-discs. The yeast two-hybrid method was used to identify possible binding partners for the insert-bearing Ig-like domain 20 of gamma-filamin. The two Ig-like domains of the recently described alpha-actinin-binding Z-disc protein myotilin were found to interact directly with this filamin domain, indicating that the amino-terminal end of gamma-filamin may be indirectly anchored to alpha-actinin in the Z-disc via myotilin. Since defects in the myotilin gene were recently reported to cause a form of autosomal dominant limb-girdle muscular dystrophy, our findings provide a further contribution to the molecular understanding of this disease.
Oliguria Following Diagnostic Translumbar Aortography (1955)

TRANSLUMBAR aortography has assumed increasing importance in clinical medicine as a diagnostic aid for a variety of conditions. This technic has been of particular importance in elucidating the pathology of intra-abdominal vascular lesions,1 and numerous reports have appeared suggesting that it is a relatively innocuous procedure with no fatal complications.2 3 4 5 One group of authors has reported over 1000 cases without any deaths or significant morbidity.6 It has been emphasized that patients with marginal renal function, impending gangrene of the extremities, allergy to iodine or in a poor general condition should not be considered candidates for this diagnostic procedure.5 Deaths after . . .
Micro-optical nonlinearity of a silver oxide layer (2001)

We studied the near-field formation mechanism of a silver oxide thin film sandwiched between protective layers using a pump probe with nanosecond laser pulse irradiation and tapping-mode tuning-fork near-field scanning optical microscopy. A multilayer composed of ZnS–SiO2/Ag2O/ZnS–SiO2 showed abnormal optical nonlinear properties compared to ordinary third-order nonlinear materials. The Ag2O layer played a role in generating a strong light scattering center in a reversible chemical reaction in only a small area of the multilayer, and the optical near field produced about the scattering center was 40 times stronger than that produced by an antimony layer instead of Ag2O.
Targeting ion channel TRPM7 promotes thymic development of Regulatory T cells by increasing IL-2-dependent STAT5 activation (2018)

In Brief Genetic deletion of Trpm7 in T-cells or pharmacological inhibition of TRPM7 channel promotes the development of fully functional T reg cells by increasing IL-2Rα and STAT5-dependent FOXP3 expression in the developing thymocytes. The study identifies the ion channel TRPM7 as a putative drug target to increase T reg numbers in vivo and induce immunotolerance. HIGHLIGHTS Ion channel TRPM7 controls T reg development The deletion of Trpm7 in the T-cell lineage increases fully functional T reg cells in the periphery TRPM7 negatively regulates Foxp3 expression by restraining IL-2-dependent STAT5 activation Inhibition of TRPM7 channel by FTY720 promotes the development of functional T reg cells SUMMARY The thymic development of regulatory T cells (T reg ), the crucial suppressors of the effector T cells (T eff ), is governed by the transcription factor FOXP3. Despite the clinical significance of T reg cells, there is a dearth of druggable molecular targets capable of increasing T reg numbers in vivo . We report a surprising discovery that TRPM7 restrains T reg development by negatively regulating STAT5-dependent Foxp3 expression. The deletion of Trpm7 potentiates the thymic development of T reg cells, leads to a significantly higher frequency of functional T reg cells in the periphery and renders the mice highly resistant to T cell-dependent hepatitis. The deletion of Trpm7 or the inhibition of TRPM7 channel activity by the FDA-approved prodrug FTY720, increases IL-2 sensitivity through a feed forward positive feedback loop involving high IL-2Rα expression and STAT5 activation. Enhanced IL-2 signaling increases the expression of Foxp3 in thymocytes and promotes the development of T reg cells. Thus, TRPM7 emerges as the first ion channel that can be drugged to increase T reg numbers, revealing a novel pharmacological path toward the induction of immune tolerance.
Plume and interplume regions and solar wind acceleration in polar coronal holes between 1.5 and 3.5 R (1997)

The observations of the polar coronal hole regions, obtained with the ultraviolet coronagraph spectrometer (UVCS) onboard the Solar and Heliospheric Observatory (SOHO), are reported on. The O VI 1032 line profiles were found to be narrower within plumes. The difference in the line width increased with the distance from the center of the sun. The analysis of the O VI 1032, H I Lyman alpha 1216 line profiles, and the O VI 1032, 1037 doublet intensity ratio is summarized. The analysis showed that the O VI line width is enhanced in interplume regions, and increases with altitude both in plume and interplume regions. The H I Lyman alpha profiles are wider in the interplume regions. From the doublet intensity ratio data, it is shown that during the minimum of the solar cycle, the acceleration of the solar wind in polar regions reaches approximately 300 km/s at 3.5 solar radii.
How to Model Solvation of Peptides? Insights from a Quantum Mechanical and Molecular Dynamics Study of<i>N</i>-Methylacetamide. 2.<sup>15</sup>N and<sup>17</sup>O Nuclear Shielding in Water and in Acetone (2005)

This paper represents the second part of a study of solvation of peptides. As in the first part, N-methyl acetamide has been used to model the specific features of solvation of the peptide linkage. In this part of the study, devoted to nuclear magnetic shieldings, acetone and water have been used as examples of polar and/or hydrogen-bond donor/acceptor solvents. Once again, three different solvation models have been tested and compared, namely, a continuum only description, a discrete description in terms of solute-solvent clusters, and a mixed discrete/continuum description in terms of clusters embedded in a continuum. Both QM and classical simulation (e.g., MD) approaches have been used to determine the structure of the clusters. The analysis of the results of the three different models, when combined with those obtained in the first part of the study devoted to IR and UV spectra, has allowed us to identify and characterize different aspects of solvation and to outline a possible computational strategy to describe dynamic and static effects due to bulk and specific peptide-solvent interactions.
Evidence for linkage of Charcot-Marie-Tooth neuropathy to the Duffy locus on chromosome 1. (1982)

A linkage study was performed on three families with classic Charcot-Marie-Tooth (CMT) hereditary neuropathy with clinical manifestations of autosomal dominant inheritance, distal muscle weakness and atrophy, hyporeflexia, and slow motor nerve conduction velocities. Two families comprising 3 and 4 generations and a total of 23 affected persons were informative for the Duffy locus known to be on the long arm of chromosome 1. The maximum total lod score was 2.297 at recombination fraction theta = .1. The third family was informative for PGM1 (on the short arm of chromosome 1). There was no evidence for linkage of CMT to PGM1 in this third family, but only values of theta less than .03 could be excluded. There was no evidence for linkage of CMT to seven other informative markers in these families. We conclude that the gene controlling the occurrence of dominant CMT may be approximately 10 centimorgans from the Duffy locus on the long arm of chromosome 1. Additional studies are required to confirm these findings.
Telemedicine: remote monitoring of cardiac patients (2004)

This paper presents a telemedicine system capable of remote monitoring cardiac patients. It includes a device which transmits the patient ECG to a monitoring center using the short message service (SMS) and data service of a TDMA cellular network. The device works in conjunction with a cellular phone handset, allowing mobility to the patient.
ChemInform Abstract: SYNTH. VON HETEROCYCLEN 147. MITT. CHINOLIZINE UND INDOLIZINE 7. MITT. SYNTH. EINES BENZINDOLIZINO‐INDIGOFARBSTOFFES (1970)

Abstract Aus dem Benzchinolizinon (I) wird durch Chlorierung und nachfolgende Umsetzung mit Na‐methylat das Ketal (II) gebildet, das beim Erhitzen mit verdünnter NaOH in das Acetal (III) übergeführt wird.
Intracellular Concentrations of 65 Species of Transcription Factors with Known Regulatory Functions in Escherichia coli (2014)

The expression pattern of the Escherichia coli genome is controlled in part by regulating the utilization of a limited number of RNA polymerases among a total of its approximately 4,600 genes. The distribution pattern of RNA polymerase changes from modulation of two types of protein-protein interactions: the interaction of core RNA polymerase with seven species of the sigma subunit for differential promoter recognition and the interaction of RNA polymerase holoenzyme with about 300 different species of transcription factors (TFs) with regulatory functions. We have been involved in the systematic search for the target promoters recognized by each sigma factor and each TF using the newly developed Genomic SELEX system. In parallel, we developed the promoter-specific (PS)-TF screening system for identification of the whole set of TFs involved in regulation of each promoter. Understanding the regulation of genome transcription also requires knowing the intracellular concentrations of the sigma subunits and TFs under various growth conditions. This report describes the intracellular levels of 65 species of TF with known function in E. coli K-12 W3110 at various phases of cell growth and at various temperatures. The list of intracellular concentrations of the sigma factors and TFs provides a community resource for understanding the transcription regulation of E. coli under various stressful conditions in nature.
Preparation of a Barium Titanate Thin Film on a Porous Titanium Body by the Hydrothermal‐Electrochemical Method (1999)

The electrolysis profile of the hydrothermal‐electrochemical method that was used to grow BaTiO 3 thin films uniformly on porous titanium bodies 5.0 mm in diameter and 1.0‐2.5 mm thick, with 32.7 vol% porosity, in an aqueous solution of Ba(OH) 2 at 150°C, was investigated. The thin films could be grown only in a surface region that was limited to a depth of lessthan equal to0.25 mm into the porous titanium body via a “single‐step” electrolysis, in which an anodic potential was applied continuously to the porous titanium body. In contrast, the thin films could be grown uniformly on the entire surface of the porous titanium body using a “cyclic” electrolysis, in which an anodic potential and a rest potential were applied alternately. The BaTiO 3 film growth inside the porous titanium body is considered to be dominated by the local solution pH.
Industrieller Einsatz der Ultrafiltration in der pharmazeutischen Biotechnologie (2004)

Abstract No abstracts.
Détection des alcools dans les milieux aqueux par un système conductimétrique bi-enzymatique (alcool oxydase/péroxydase de raifort) (2011)

communication par affiche
PRECESSION AND CHAOS IN THE CLASSICAL TWO-BODY PROBLEM IN A SPHERICAL UNIVERSE (2008)

We generalize the classical two-body problem from flat space to spherical space and realize much of the complexity of the classical three-body problem with only two bodies. We show analytically, by perturbation theory, that small, nearly circular orbits of identical particles in a spherical universe precess at rates proportional to the square root of their initial separations and inversely proportional to the square of the universe's radius. We show computationally, by graphically displaying the outcomes of large open sets of initial conditions, that large orbits can exhibit extreme sensitivity to initial conditions, the signature of chaos. Although the spherical curvature causes nearby geodesics to converge, the compact space enables infinitely many close encounters, which is the mechanism of the chaos.
IGF-I 3′ Untranslated Region: Strain-Specific Polymorphisms and Motifs Regulating IGF-I in Osteoblasts (2012)

Reduced IGF-I is associated with low bone mass in humans and mice. C3H/He/J (C3H) mice have higher skeletal IGF-I and greater bone mass than C57BL/6J (B6). We hypothesized that strain-related genotypic differences in Igf1 affected skeletal function. The Igf1 coding region is nonpolymorphic, but its 3' untranslated region (UTR) is polymorphic between C3H and B6. Luciferase-Igf1 3' UTR reporter constructs showed that these polymorphic regions did not affect UTR function. IGF-I splice variants give rise to a common mature IGF-I peptide, but different E peptides. We identified two splice products, exon 4+6 (Ea) and exon 4+5+6 (Eb, mechano-growth factor) and found that their abundance was unchanged during osteoblastic differentiation. The Igf1 3' UTR encoded by exon 6 contains alternative polyadenylation sites. Proximal site use produces a short 3' UTR of approximately 195 bases, whereas distal site usage results in an approximately 6300-base UTR. Although Igf1 mRNA levels did not change during osteoblastic differentiation, distal polyadenylation site usage was increased in B6 cells but not in C3H. The resulting long Igf1 RNA isoform is less stable and has decreased translation efficiency, which may be one mechanism contributing to decreased IGF-I in B6 vs. C3H mice. Although the long UTR contains a conserved [GU](18) repeat, which is a positive regulator of UTR activity, it is also targeted by negative regulators, miR-29 and miR-365. These microRNAs are increased in B6 and C3H cells during osteoblastic differentiation. Differential expression of the long Igf1 3' UTR isoform may be a possible mechanism for enhanced IGF-I regulation in B6 vs. C3H mice.
Accelerators for Positron Emission Tomography (1993)

The positron emitters Carbon-11, Nitrogen-13, Oxygen-15 and Fluorine-18 can be conveniently produced using low energy particle accelerators. The requirement is for these accelerators to deliver particle beams of sufficient energy to bring about the required nuclear reactions and with sufficient beam current to bring about practical yields of the required radionuclides. Table 1 lists the positron emitters, their characteristics and the most common nuclear reactions for their production which are in use today.