gebhart/patrepeval huggingface dataset:
Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine (1997)

The effects of the psychotomimetic drug phencyclidine on the neurochemistry and function of the prefrontal cortex in vervet monkeys were investigated. Monkeys treated with phencyclidine twice a day for 14 days displayed performance deficits on a task that was sensitive to prefrontal cortex function; the deficits were ameliorated by the atypical antipsychotic drug clozapine. Repeated exposure to phencyclidine caused a reduction in both basal and evoked dopamine utilization in the dorsolateral prefrontal cortex, a brain region that has long been associated with cognitive function. Behavioral deficits and decreased dopamine utilization remained after phencyclidine treatment was stopped, an indication that these effects were not simply due to direct drug effects. The data suggest that repeated administration of phencyclidine in monkeys may be useful for studying psychiatric disorders associated with cognitive dysfunction and dopamine hypofunction in the prefrontal cortex, particularly schizophrenia.
Response of Sediment Bacterial Assemblages To Selenate and Acetate Amendments (2000)

We followed the response of bacterial assemblages in slurries of estuarine sediments to amendments of 100 microM sodium selenate and 10 mM sodium acetate. Selenate was removed from the dissolved phase in all slurries after an initial lag that varied depending on the source of the sediment used in the slurry. Subsequent selenate amendments were removed without a lag but with the appearance of transient peaks of selenite. We documented changes in the composition of bacterial assemblages in the slurries using PCR/DGGE and RT-PCR/DGGE of 16S rDNA and rRNA. Bands of interest were sequenced to identify organisms responding to selenate amendments. The composition of communities from the two sampling sites was different and changed but did not converge during incubations with selenate. Selenate-reducing assemblages had broad phylogenetic diversity. Most bands were related to groups of bacteria known to contain organisms capable of selenate or selenite reduction, except for Acinetobacter species which dominated one of the samples and has not previously been associated with selenium oxyanion reduction.
Invited Review: Integration of human sleep-wake regulation and circadian rhythmicity (2002)

The human sleep-wake cycle is generated by a circadian process, originating from the suprachiasmatic nuclei, in interaction with a separate oscillatory process: the sleep homeostat. The sleep-wake cycle is normally timed to occur at a specific phase relative to the external cycle of light-dark exposure. It is also timed at a specific phase relative to internal circadian rhythms, such as the pineal melatonin rhythm, the circadian sleep-wake propensity rhythm, and the rhythm of responsiveness of the circadian pacemaker to light. Variations in these internal and external phase relationships, such as those that occur in blindness, aging, morning and evening, and advanced and delayed sleep-phase syndrome, lead to sleep disruptions and complaints. Changes in ocular circadian photoreception, interindividual variation in the near-24-h intrinsic period of the circadian pacemaker, and sleep homeostasis can contribute to variations in external and internal phase. Recent findings on the physiological and molecular-genetic correlates of circadian sleep disorders suggest that the timing of the sleep-wake cycle and circadian rhythms is closely integrated but is, in part, regulated differentially.
The Prague Mime Festival (1970)

This, and several electric moments onstage, were direct reflections of the current political situation. One such moment occurred during Marcel Marceau's concert: his sketch The Cage is a parable of a man imprisoned in a cage who breaks out of it, only to find that his prison had been enclosed in a still larger one. I had seen it many times before, but suddenly, half way through it, I gasped with the realization of its appropriateness to Prague in September 1969. The tense, silent Czech audience greeted its finish with rolling waves of applause prolonged insistently into the next number, and gave the artist forty-four curtains at the end of the program. Other pieces, too, took on additional import. Marceau's new mime The Hands depicts a conflict between the Benign Hand and the Evil Hand; in one scene of The Button by Ladislav Fialka's Czech company, people walk through walls into a room, then find that it is a one-way passage; and a delightful sketch of a poorly-functioning television set suddenly became a commentary on the political control of the medium.
L'ornementation métallique et ses altérations: Maître de Burgo de Osma.... (1998)

In the dog, FFA (free fatty acid) and cortisol levels in arterial blood plasma are lowered by anesthesia. Induced hypercapnia does not alter the cortisol levels but increases FFA levels. Hypoxia tends to raise the FFA levels. Possible causes of modifications in the FFA and cortisol levels are briefly discussed.
DNA-Based Taxonomy in Ecologically Versatile Microalgae: A Re-Evaluation of the Species Concept within the Coccoid Green Algal Genus Coccomyxa (Trebouxiophyceae, Chlorophyta) (2016)

Coccomyxa is a genus of unicellular green algae of the class Trebouxiophyceae, well known for its cosmopolitan distribution and great ecological amplitude. The taxonomy of this genus has long been problematic, due to reliance on badly-defined and environmentally variable morphological characters. In this study, based on the discovery of a new species from an extreme habitat, we reassess species circumscription in Coccomyxa, a unicellular genus of the class Trebouxiophyceae, using a combination of ecological and DNA sequence data (analyzed with three different methods of algorithmic species delineation). Our results are compared with those of a recent integrative study of Darienko and colleagues that reassessed the taxonomy of Coccomyxa, recognizing 7 species in the genus. Expanding the dataset from 43 to 61 sequences (SSU + ITS rDNA) resulted in a different delimitation, supporting the recognition of a higher number of species (24 to 27 depending on the analysis used, with the 27-species scenario receiving the strongest support). Among these, C. melkonianii sp. nov. is described from material isolated from a river highly polluted by heavy metals (Rio Irvi, Sardinia, Italy). Analyses performed on ecological characters detected a significant phylogenetic signal in six different characters. We conclude that the 27-species scenario is presently the most realistic for Coccomyxa and we suggest that well-supported lineages distinguishable by ecological preferences should be recognized as different species in this genus. We also recommend that for microbial lineages in which the overall diversity is unknown and taxon sampling is sparse, as is often the case for green microalgae, the results of analyses for algorithmic DNA-based species delimitation should be interpreted with extreme caution.
Regulation of Neural Specification from Human Embryonic Stem Cells by BMP and FGF (2009)

Inhibition of bone morphogenetic protein (BMP) signaling is required for vertebrate neural induction, and fibroblast growth factors (FGFs) may affect neural induction through phosphorylation at the linker region of Smad1, thus regulating BMP signaling. Here we show that human embryonic stem cells efficiently convert to neuroepithelial cells in the absence of BMP antagonists, or even when exposed to high concentrations of exogenous BMP4. Molecular and functional analyses revealed multiple levels of endogenous BMP signaling inhibition that may account for the efficient neural differentiation. Blocking FGF signaling inhibited neural induction, but did not alter the phosphorylation of the linker region of Smad1, suggesting that FGF enhances human neural specification independently of BMP signaling.
Le Generator: A Test Data Synthesis Framework (2009)

1. The effects of hypoxia and asphyxia on cerebral blood flow and oxidative metabolism have been investigated in the calf and lamb under sodium pentobarbitone anaesthesia. 2. Cerebral blood flow was determined using a hydrogen clearance technique, and cerebral metabolism quantified by the simultaneous measurement of arteriocerebral venous concentration differences for oxygen, glucose and lactate. Continuous measurements were made of arterial and cerebral venous PO2 in vivo. 3. Both cerebral blood flow and oxygen consumption were less in animals anaesthetized with sodium pentobarbitone than in conscious animals. 4. In the calf, recovery from transient episodes of severe hypoxia and asphyxia was associated with a rapid recovery and overshoot of cerebral venous PO2. Evidence was obtained that rapid changes in blood pressure during severe asphyxia were associated with pressure-passive cerebral blood flow. Prolonged hypoxia (Pa,O2:21 +/- 2 mmHg) with normocapnia was associated with an increase in cerebral blood flow, fall in cerebral oxygen consumption, and no change in the glucose-oxygen index. 5. In the lamb, prolonged asphyxia (Pa,O2:30 +/- 1 mmHg; Pa,CO2:56 +/- 2 mmHg) was associated with an increase in cerebral blood flow. Cerebral glucose uptake did not change, but cerebral oxygen consumption was markedly depressed, and the glucose-oxygen index increased. 6. In the lamb during normoxia, there was a linear correlation between cerebral blood flow and arterial PCO2 in the range 10-95 mmHg (r = 0.92; P < 0.001), with a slope of 1.74 ml. 100g-1 min-1 . mmHg Pa,CO2-1 . Hypoxia did not significantly increase the fall in cerebral vascular resistance associated with a rise in Pa,CO2 from 34 to 56 mmHg.
Error resilience schemes of H.264/AVC for 3G conversational video services (2005)

The emerging of third generation mobile system (3G) makes conversational video transmission in wireless environment possible, and the latest 3GPP/3GPP2 standards suggest 3G terminals support H.264/AVC. Due to high bit error rate in wireless environment, error resilience schemes are necessary for 3G terminals. Moreover, according to 3GPP/3GPP2, 3G terminals support only part of error resilience tools of H.264/AVC. This paper lists various error resilience tools and analyzes their usability in 3G environment, and at the same time, some error resilience schemes are proposed. Performances of these error resilience schemes are tested using offline common test conditions. Experiments shows that, in 3G environment, encoding with simple FMO mode and extra intra block refreshing can achieve the best error correction ability, because this method can make full use of spatial correlation for intra predication and reduce the requirement of bit rate.
Frequency and clinical features of intraocular inflammation in Tokyo (2009)

The most frequent diagnoses were sarcoidosis, VKH disease, acute anterior uveitis, Behçet's disease and tuberculosis, with Behçet's disease being common in young men and sarcoidosis being common in elderly women. One-fourth of patients received systemic corticosteroids and 8.7% of patients required other immunomodulatory agents.
Effect of two randomised exercise programmes on bone mass of healthy postmenopausal women. (1987)

The effect of two structured exercise programmes on the bone mass of 48 healthy postmenopausal white women aged 50-62 was studied after one year. Volunteers were randomised to group 1 (control), group 2 (aerobic exercise), or group 3 (aerobic and strengthening exercises). Before and after the training programme each subject had evaluations of bone mass (determined by neutron activation analysis and expressed as calcium bone index) and maximum oxygen uptake attained on a multistage exercise treadmill test. After one year both exercise groups had higher levels of fitness and greater bone mass than controls. Mean values (2 SEM) for changes in the calcium bone index were -0.011 (0.037), 0.039 (0.035), and 0.066 (0.036) for groups 1, 2, and 3, respectively. Analysis of variance on the observed data and analysis of covariance adjusting changes to the initial mean value for the whole group showed significant differences between each exercise group and the controls but no difference between the exercise groups themselves. Both exercise groups showed a significant improvement in maximum oxygen uptake. This study suggests that exercise may modify bone loss in healthy postmenopausal women.
Synthesis and Antimicrobial Activity of Pyridines Bearing Thiazoline and Moieties. (1998)

Two series of new pyridines bearing thiazoline (3a--n) and thiazolidinone (5a--e) moieties were prepared via the cyclization of the corresponding substituted pyridyl thiourea (2a--g) with an appropriately substituted phenacyl bromide or chloroacetic acid, respectively. The antimicrobial activity was determined for representative compounds and most of them showed moderate activity against Gram-positive bacteria.
Prodrug Strategy in Drug Development (2016)

Abstract Prodrugs are chemically modified derivatives introduced in therapy due to their advantageous physico-chemical properties (greater stability, improved solubility, increased permeability), used in inactive form. Biological effect is exerted by the active derivatives formed in organism through chemical transformation (biotransformation). Currently, 10% of pharmaceutical products are used as prodrugs, nearly half of them being converted to active form by hydrolysis, mainly by ester hydrolysis. The use of prodrugs aims to improve the bioavailability of compounds in order to resolve some unfavorable characteristics and to reduce first-pass metabolism. Other objectives are to increase drug absorption, to extend duration of action or to achieve a better tissue/organ selective transport in case of non-oral drug delivery forms. Prodrugs can be characterized by chemical structure, activation mechanism or through the presence of certain functional groups suitable for their preparation. Currently we distinguish in therapy traditional prodrugs prepared by chemical derivatisation, bioprecursors and targeted delivery systems. The present article is a review regarding the introduction and applications of prodrug design in various areas of drug development.
Detection of human papillomavirus in large cell neuroendocrine carcinoma of the uterine cervix: a study of 12 cases (2002)

Integration of high risk HPV, in particular type 16 and to a lesser extent type 18, is associated with this uncommon variant of cervical carcinoma.
Experimentelle Überprüfung des Aufweitverhaltens von ballonexpandierbaren Koronarstents (1997)

Article Experimentelle Überprüfung des Aufweitverhaltens von ballonexpandierbaren Koronarstents was published on January 1, 1997 in the journal Biomedical Engineering / Biomedizinische Technik (volume 42, issue s2).
PTPRG (protein tyrosine phosphatase, receptor type, G) (2011)

Review on PTPRG (protein tyrosine phosphatase, receptor type, G), with data on DNA, on the protein encoded, and where the gene is implicated.
Object-oriented simulation of pneumatic conveying-application to a turbulent flow (1999)

In this work a model was developed to describe the dynamic behavior of fluid and particles in pneumatic conveying. The object-oriented simulation (OOS) technique was applied, which allowed a discrete, deterministic and transient treatment for the particulate phase. The fluid phase was modeled assuming a pseudo two-dimensional flow, separated from the particulate phase. The dynamic effects coupling both phases were taken into account in the interaction terms as the drag force acting on the particles and the momentum generation in the fluid phase. The model presented in this work considers bidirectional coupling of the particulate and fluid phases and tridimensional movement of the particles. The properties of the object-oriented technique allow the simulation of polydispersed mixtures, permitting segregation studies in pneumatic conveying.
Measurement of in-vehicle channel &#x2014; Feasibility of ranging in UWB and MMW band (2014)

This paper provides results of radio channel measurement campaign carried out in the intra vehicle environment for ultra-wide band (UWB) and millimeter wave (MMW) frequency bands, namely 3-11 GHz and 55-65 GHz. In discussed frequency bands, we present and compare channel impulse responses (CIRs) for various antenna locations while considering the effect of passengers presence. On the basis of performed statistical evaluation of time of arrival (TOA) based ranging system deployed in mentioned bands, we discuss feasibility and precision of local positioning systems for intra vehicle ambiance.
Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy (2002)

A reduction of NAA within the gray matter of patients suggests neuronal dysfunction. Altered phospholipid metabolism suggestive of a trend toward decreased volume is implicated with a reduction of Cho concentrations. Within white matter, composite concentrations of AAs were elevated in patients indicating altered neurotransmission.
Designing Network Failover and Recovery in MPI for Multi-Rail InfiniBand Clusters (2012)

The emerging trends of designing commodity-based supercomputing systems have a severe detrimental impact on the Mean-Time-Between-Failures (MTBF). The MTBF for typical HEC installations is currently estimated to be between eight hours and fifteen days [1]. Failures in the interconnect fabric account for a fair share of the total failures occurring in such systems. This will continue to degrade as system sizes become larger. Thus, it is highly desirable that next generation system architectures and software environments provide sophisticated network level fault-tolerance and fault-resilient solutions. In the past few years, the number of cores on processors has increased dramatically. To make efficient use of these machines it is necessary to provide the required bandwidth to all the cores. To keep up with the multi-core trend, current generation supercomputers and clusters are designed with multiple network cards (rails) to provide enhanced data transfer capabilities. Besides providing enhanced performance, such multi-rail networks can also be leveraged to provide network level fault resilience. This paper presents a design for a failover mechanism in a multi-rail scenario, for handling network failures and their recovery without compromising on performance. In a general message passing scenario, whenever there is a network failure, the entire job aborts. Our design allows the job to continue even when a network failure occurs, by using the remaining rails for communication. Once the rail recovers from the failure, we also propose a protocol to re-establish connections on that rail and resume normal operations. We experimentally demonstrate that our implementation adds very little overhead and is able to deliver good performance which is comparable to that of the other rails running in isolation. We also show that the recovery is immediate and is associated with no additional overhead. We also depict sustenance and reliability of the design by running application benchmarks with permanent failures.
Correlation of bitterness thresholds of amino acids and peptides with molecular connectivity (1980)

Abstract Molecular connectivity values are easily calculated topological indices related to the degree of branching (hence the size and shape) of any chemical structure considered. These structural parameters are significantly correlated with literature values for the bitterness thresholds of amino acids, peptides and their derivatives. The quantitative correlation of flavour thresholds with structural parameters may prove useful for predicting thresholds of untested compounds; the potential and disadvantages of this approach are discussed.
Quantitative analysis of plant ER architecture and dynamics (2019)

The endoplasmic reticulum (ER) is a highly dynamic polygonal membrane network composed of interconnected tubules and sheets (cisternae) that forms the first compartment in the secretory pathway involved in protein translocation, folding, glycosylation, quality control, lipid synthesis, calcium signalling, and metabolon formation. Despite its central role in this plethora of biosynthetic, metabolic and physiological processes, there is little quantitative information on ER structure, morphology or dynamics. Here we describe a software package (AnalyzER) to automatically extract ER tubules and cisternae from multi-dimensional fluorescence images of plant ER. The structure, topology, protein-localisation patterns, and dynamics are automatically quantified using spatial, intensity and graph-theoretic metrics. We validate the method against manually-traced ground-truth networks, and calibrate the sub-resolution width estimates against ER profiles identified in serial block-face SEM images. We apply the approach to quantify the effects on ER morphology of drug treatments, abiotic stress and over-expression of ER tubule-shaping and cisternal-modifying proteins.
IN SITU OBSERVATION ON FORMATION OF BASKET DURING BAINITIC TRANSFORMATION (1989)

By means of riM-190 hot-stage microscopy,the in situ observation of α-β transformation in 12Cr2MoWVTiB steel has been carried out.The sequence of the growth of ferritic needles composing bainitic basket has also been determined.According to the crystallographic analy- sis a multislip system transform model concerning the formation of basket has been proposed.
Micro<scp>RNA</scp>‐29c Correlates with Neuroprotection Induced by <scp>FNS</scp> by Targeting Both Birc2 and Bak1 in Rat Brain after Stroke (2015)

MiR-29c correlates with the neuroprotection induced by FNS by negatively regulating Birc2 and Bak1.
Optical coherence tomography-based scanning system for shape determination, wall thickness mapping, and inner inspection of glass containers (2013)

In this work we present a method that enables simultaneous measurement of shape and wall parameters of glass containers. The system is based on the optical coherence tomography technique, employing the spectral domain configuration. The data were obtained by measuring the spatial coordinates of a sequence of points in a predefined region of a sample that includes points on the surface and in the interior of the material. Dimensional parameters, thickness mapping, and tomography studies of the interior of the sample walls can be obtained from these measurements.
Simultaneous Facial Feature Tracking and Facial Expression Recognition (2013)

The tracking and recognition of facial activities from images or videos have attracted great attention in computer vision field. Facial activities are characterized by three levels. First, in the bottom level, facial feature points around each facial component, i.e., eyebrow, mouth, etc., capture the detailed face shape information. Second, in the middle level, facial action units, defined in the facial action coding system, represent the contraction of a specific set of facial muscles, i.e., lid tightener, eyebrow raiser, etc. Finally, in the top level, six prototypical facial expressions represent the global facial muscle movement and are commonly used to describe the human emotion states. In contrast to the mainstream approaches, which usually only focus on one or two levels of facial activities, and track (or recognize) them separately, this paper introduces a unified probabilistic framework based on the dynamic Bayesian network to simultaneously and coherently represent the facial evolvement in different levels, their interactions and their observations. Advanced machine learning methods are introduced to learn the model based on both training data and subjective prior knowledge. Given the model and the measurements of facial motions, all three levels of facial activities are simultaneously recognized through a probabilistic inference. Extensive experiments are performed to illustrate the feasibility and effectiveness of the proposed model on all three level facial activities.