gebhart/patrepeval huggingface dataset:
Hydrophobic Monomer Type and Hydrophilic Monomer Ionization Modulate the Lyotropic Phase Stability of Diblock Co-oligomer Amphiphiles (2017)

The phase behavior and self-assembly structures of a series of amphiphilic diblock co-oligomers comprising an ionizable hydrophilic block (5 to 10 units of acrylic acid) and a hydrophobic block (5 to 20 units of n-butyl acrylate, t-butyl acrylate, or ethyl acrylate), synthesized by RAFT polymerization, have been examined by polarizing optical microscopy and small-angle X-ray scattering (SAXS). Self-assembled structure and lyotropic phase stability in these systems is highly responsive to the degree of ionization of the acrylic acid hydrophilic block (i.e., pH), concentration, and nature of the hydrophobic block. Increasing headgroup ionization switched the amphiphiles from behaving like soluble to insoluble surfactants. Liquid isotropic (micellar), hexagonal, lamellar, and discrete cubic phases were found under different solution conditions. The surfactant packing parameter was adapted to understand the self-assembly structures in these diblock co-oligomers. The hydrophobic chain structure and length were shown to strongly affect the relative stabilities of these phases, allowing the self-assembled structure to be varied at will.
Development of a linear alternator-engine for hybrid electric vehicle applications (1999)

This paper examines the design and operation of a generation system that utilizes a linear crankless internal combustion engine in conjunction with a linear alternator. This system directly utilizes the linear motion of the piston to drive the alternator rather than first converting to rotary motion. The result is a more compact, reliable, and efficient unit as the system has only one moving part, making the system ideal for use in series hybrid electric vehicles. This paper describes the overall system design as well as the subsystems including the engine and alternator. A dynamic simulation is then presented which utilizes the model developed to determine the output characteristics of the system. The prototype system was successfully tested, and experimental results are also included.
AN ANALYSIS OF OPHTHALMIC LENS DESIGN (1964)

American Optical Company Southbridge, Massachusetts *Read before the annual meeting of the American Academy of Optometry, Chicago, Illinois, December 10, 1963. For publication in the July. 1964, issue of the American Journal of Optometry and Archives of American Academy of Optometry. †Lens Development Manager. Fellow, American Academy of Optometry. ‡Lens Development Engineer. §Lens Development Engineer. Fellow, American Academy of Optometry.
LC/GC, SFC/GC, and SFE/GC (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLC/GC, SFC/GC, and SFE/GCIlona L. Davies, Mark W. Raynor, Jacob P. Kithinji, Keith D. Bartle, Paul T. Williams, and Gordon E. AndrewsCite this: Anal. Chem. 1988, 60, 11, 683A–702APublication Date (Print):June 1, 1988Publication History Published online22 September 2008Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/ac00162a001https://doi.org/10.1021/ac00162a001research-articleACS PublicationsRequest reuse permissionsArticle Views382Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors (2013)

Primary cilia serve as cellular antenna for various sensory signaling pathways. However, how the sensory receptors are properly targeted to the ciliary surface remains poorly understood. Here, we show that UBC-9, the sole E2 small ubiquitin-like modifier (SUMO)-conjugating enzyme, physically interacts with and SUMOylates the C terminus of small GTPase ARL-13, the worm orthologue of ARL13B that mutated in ciliopathy Joubert syndrome. Mutations that totally abolish the SUMOylation of ARL-13 do not affect its established role in ciliogenesis, but fail to regulate the proper ciliary targeting of various sensory receptors and consequently compromise the corresponding sensory functions. Conversely, constitutively SUMOylated ARL-13 fully rescues all ciliary defects of arl-13-null animals. Furthermore, SUMOylation modification of human ARL13B is required for the ciliary entry of polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease. Our data reveal a novel but conserved role for the SUMOylation modification of ciliary small GTPase ARL13B in specifically regulating the proper ciliary targeting of various sensory receptors.
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array (2013)

We conclude that tDMRs preferentially occur in CpG-poor regions and are associated with alternative transcription. Furthermore, our data suggest the utility of creating an atlas cataloguing variably methylated regions in internal tissues that correlate to DNA methylation measured in easy accessible peripheral tissues.
Regulatory gene network between SuHV-1 genes and detected viRs and most abundant DE host miRNAs in infected samples. (2015)

<p>Node shape represents either is a viral miRNA (hexagon, bright green), a host miRNA (hexagon, dark green) or a viral gene (circular). Node size simulates the number of interactions, which is directly proportional. Viral gene function is represented by colour: yellow means structural function (virion envelope, tegument or capside proteins); purple means regulatory function; blue represents viral egress function and grey means unknown function. LLT transcript is marked in RED and <i>EP0</i> and <i>IE180</i> viral activators are marked in orange.</p>
A simple method to estimate relative stabilities of polyethers cationized by alkali metal ions (2011)

Dissociation of doubly cationized polyethers, namely [P + 2X](2+) into [P + X](+) and X(+), where P = polyethylene glycol (PEG), polypropylene glycol (PPG) and polytetrahydrofuran (PTHF) and X = Na, K and Cs, was studied by means of energy-dependent collision-induced dissociation tandem mass spectrometry. It was observed that the collision voltage necessary to obtain 50% fragmentation (CV(50)) determined for the doubly cationized polyethers of higher degree of polymerization varied linearly with the number of degrees of freedom (DOF) values. This observation allowed us to correlate these slopes with the corresponding relative gas-phase dissociation energies for binding of alkali ions to polyethers. The relative dissociation energies determined from the corresponding slopes were found to decrease in the order Na(+) > K(+) > Cs(+) for each polyether studied, and an order PPG ≈ PEG > PTHF can be established for each alkali metal ion.
The Influence of MSI (Metal-Support Interactions) and the Solvent in Liquid-Phase Reactions (2003)

Results were repeatedly obtained that were consistent with a hypothesis proposed at the beginning of this program, i.e., due to Metal-Support Interactions (MSI), unique active sites can be created in the metal-support interfacial region to enhance activity and improve selectivity in certain types of reactions, especially those involving the hydrogenation of carbonyl and unsaturated C=C bonds. Higher turnover frequencies (TOF-molecule/s/site) and increased selectivity for C=O bond versus C=C bond hydrogenation was established in the hydrogenation reactions of: acetone, crotonaldehyde, acetophenone, phenylethanol, acetylcyclohexane, benzaldehyde, benzyl alcohol, phenylacetaldehyde and citral over Pt/TiO{sub 2} MSI catalysts. Higher rates of hydrogenation benzene, toluene and xylene could be obtained over certain supported Pt and Pd catalysts. Au/TiO{sub 2} catalysts were developed that were active for CO hydrogenation at subambient temperatures. The influence of support and metal crystallite size were established for the adsorption of H{sub 2}, CO and O{sub 2} on families of Pt and Pd catalysts.
Is Portal Hypertension a Contraindication to Hepatic Resection? (2009)

Faced with the same MELD score and extent of hepatectomy planning, presence of portal hypertension should not be considered as a contraindication for hepatic resection in cirrhotic patients.
‘Short’ Double-Balloon Enteroscope for Endoscopic Retrograde Cholangiopancreatography in Patients with a Surgically Altered Upper Gastrointestinal Tract (2011)

DBEs enable successful diagnostic and therapeutic ERCP in patients with a surgically altered anatomy of the upper gastrointestinal tract. It is a safe, feasible and less invasive therapeutic option in this group of patients. Standard 'long' DBEs have limitations of long working length and the need for modified ERCP accessories. 'Short' DBEs are equally as effective in reaching the target limb as standard 'long' DBEs, and overcomes some limitations of long DBEs to result in high success rates for endoscopic therapy.
Development of electrtomagnetic driven artificial heart. (1988)

The development of totally implantable artificial heart is indispensable to rehabiliate a patient who has a serious heart disease. An electromagnet which has decoupling springs to increase the energy conversion efficiency was chosen as the energy converter. The virtual magnetic path method was employed to design the electromagnet. Energy source was a nickel cadmium battery. Using a portable driver, the electromagnet was supplied with adequate amount of energy. The blood pump was pusher plate type. The armature of the electromagnet supplied the driving force to the pusher plate through plate springs and links which were magnify the stroke of the armature. The maximum energy conversion efficiency of the prototype electromagnet itself was 35[%]. The prototype device was 1.84[kg]in weight(W101×H80×D1600[mm]), the portable driver for the electromagnet was 0.9[kg]in weight(W150×H54×D170[mm]), and total efficiency was 6[%].
Toward 4-D Trajectory Management in Air Traffic Control: A Study Based on Monte Carlo Simulation and Reachability Analysis (2012)

One of the fundamental elements for the next generation in air traffic management systems, as envisioned by the Single European Sky Air Traffic Management Research Project and the Next Generation Air Transportation System Project, is 4-D trajectory management. In the contract-based air transportation system project, a novel concept of operations based on target windows (TWs) is developed. TWs are 4-D constraints imposed at different parts of the flight to increase predictability, efficiency, and safety. In this paper, we use Monte Carlo simulations and reachability analysis to evaluate some of these features of the TW concept. We start by using Monte Carlo methods to estimate the TW hitting probability and the probability of conflict. We then outline methods and computational tools based on reachability theory and highlight how they can be adapted to characterize the maneuvering freedom afforded by TWs. We also demonstrate how the reachability calculations can be used to guide conflict resolution in the presence of TW constraints. Our results indicate that TWs provide a promising balance between predictability of air traffic and maneuverability.
Lecithin‐protein interaction in the GTP‐dependent acyl‐CoA synthase (1969)

Abstract The enzymic activity of the GTP‐dependent acyl‐CoA synthase isolated from rat liver mitochondria is affected by removal and addition of lecithin (3). Purified preparations of this enzyme contain bound lecithin. In this presentation the nature of the lecithin‐protein interaction is examined. From binding measurements at different temperatures it is possible to postulate which type of secondary valence bonds is holding the protein and lecithin together.
Startle‐induced seizures associated with infantile hemiplegia: implication of the supplementary motor area (2005)

This case illustrates an uncommon form of symptomatic startle-induced epilepsy associated with infantile hemiplegia. Seizure semiology, neuroimaging and neurophysiological findings support involvement of the supplementary motor area in the generation of this seizure type. We present the case of an 11-year-old girl with an uncommon form of startle-induced seizures, illustrated on video-EEG, against the background of left infantile hemiplegia associated with extensive right hemispheric porencephaly but preserved cognitive functioning. The epileptic focus appears to be in the dorsolateral frontal lobe, with seizure semiology involving the supplementary motor cortex.
A ntibodies against a human endogenous retrovirus and the preponderance of env splice variants in multiple sclerosis patients (2003)

The human endogenous retrovirus HERV-H is associated with multiple sclerosis (MS). Previously performed reverse transcriptase-polymerase chain reactions (RT-PCR) on virion-RNA demonstrated sequence variants of the HERV-H family located in the particulate fraction of MS patient plasma samples and not in controls. In this study a significantly elevated level of antibodies towards peptides derived from HERV-H/RGH-2 DNA sequences in serum and cerebrospinal fluid (CSF) from MS patients is demonstrated. Further, Wistar rats immunized with purified virions develop a specific serologic response, indicating that some virion proteins are encoded by HERV-H-related sequences. Also shown is that in RNA from blood cells, a HERV-H protease-env splice variant can be found together with an env splice variant in about 40% of MS patients but only in 10% of controls. The results substantiate the association between activated HERV-H and MS, but a causal relationship is yet to be demonstrated. HERV-H could represent a causal factor either by eliciting an autoimmune response or through the pathogenic potential of the retrovirus itself.
Time dependent physical properties of semicrystalline poly(arylene ether ether ketone) (PEEK) above its glass transition temperature: Physical aging vs. secondary crystallization (1995)

We monitored the change in small strain short term isothermal creep compliance of semicrystalline. PEEK (T{sub g} {approx} 150{degrees}C - 165{degrees}C) at various temperatures from 120{degrees}C to 260{degrees}C. With increase of aging times creep curves are shifted to longer times, implying slowing down of the mechanical relaxation of the polymer. The isothermal horizontal shift rate is close to unity below and above T{sub g} and exhibits significant drop in the glass transition region.
Targeted Therapy in Prostate Cancer (2008)

New therapeutic advances in Phase I to III clinical trials against castration-resistant prostate cancer strive to manipulate the androgen receptor, a growth and survival mediator; reduce circulating androgen concentrations; combat antiapoptotic proteins; and target pathways related to angiogenesis. Immunotherapeutic studies are based on a better understanding of the prostate’s testosterone-dependent organogenesis and functional differentiation at puberty. Bone, because it is the site of first relapse in more than 80% of cases and is the tissue most frequently involved in hormone-refractory cases, remains of prominent interest for interventions.
A review of signal energy analysis for the rapid determination of dynamic security limits (1996)

This article presents an overview of the signal energy method for the rapid determination of power system dynamic security limits. The key questions concerning this method are addressed. These include: (1) What is the basis of signal energy transient-stability-limit estimation? (2) Which physical quantity(ies) yield(s) the most accurate estimates? (3) How is the method used for accelerating the transient-stability-limit search? and (4) Can it be adapted to multiple-processor environments (i.e., either multiprocessor work stations or local area networks (LANs))? Signal energy limit search strategies, deployed on single-processor hardware, are shown to be extremely rapid and accurate, and to compare favourably to the published performance of the only other known method for accelerating the transient-stability-limit search (i.e., the “second kick” method). Also, tests show that by combining signal energy analysis and multiple processors, transient-stability-transfer-limit determination is achievable, on average, in less than the time required for two simulations and with an error under 1%.
Joint Source and Channel Coding (2010)

The objectives of this article are two-fold: First, to present the problem of joint source and channel (JSC) coding from a graphical model perspective and second, to propose a structure that uses a new graphical model for jointly encoding and decoding a redundant source. In the first part of the article, relevant contributions to JSC coding, ranging from the Slepian-Wolf problem to joint decoding of variable length codes with state-of-the-art source codes, are reviewed and summarized. In the second part, a double low-density parity-check (LDPC) code for JSC coding is proposed. The double LDPC code can be decoded as a single bipartite graph using standard belief propagation (BP) and its limiting performance is analyzed by using extrinsic information transfer (EXIT) chart approximations.
Both Lymantria dispar nucleopolyhedrovirus enhancin genes contribute to viral potency (2003)

Enhancins are a group of proteins first identified in granuloviruses (GV) that have the ability to enhance nuclear polyhedrosis virus potency. We had previously identified an enhancin gene (E1) in the Lymantria dispar multinucleocapsid nucleopolyhedrovirus (LdMNPV) (D. S. Bischoff and J. M. Slavicek, J. Virol. 71:8133-8140, 1997). Inactivation of the E1 gene product within the viral genome lowered viral potency by an average of 2.9-fold. A second enhancin gene (E2) was identified when the entire genome of LdMNPV was sequenced (Kuzio et al., Virology 253:17-34, 1999). The E2 protein exhibits approximately 30% amino acid identity to the LdMNPV E1 protein as well as the enhancins from Trichoplusia ni GV, Pseudaletia unipuncta GV, Helicoverpa armigera GV, and Xestia c-nigrum GV. Northern analysis of viral RNA indicated that the E2 gene transcripts are expressed at late times postinfection from a consensus baculovirus late promoter. The effect of the enhancin proteins on viral potency was investigated through bioassay using two recombinant viruses, one with a deletion in the E2 gene (E2del) and a second with deletion mutations in both enhancin genes (E1delE2del). The enhancin gene viral constructs were verified by Southern analysis and shown not to produce enhancin gene transcripts by Northern analysis. The E2del virus exhibited an average decrease in viral potency of 1.8-fold compared to wild-type virus. In the same bioassays, the recombinant virus E1cat, which does not produce an E1 gene transcript, exhibited an average decrease in viral potency of 2.3-fold compared to control virus. The E1delE2del virus exhibited an average decrease in viral potency of 12-fold compared to wild-type virus. Collectively, these results suggest that both LdMNPV enhancin genes contribute to viral potency, that each enhancin protein can partially compensate for the lack of the other protein, and that both enhancin genes are necessary for wild-type viral potency.
Stability and electronic properties of groups IIB to VB metal ions in unusual oxidation states and the /sup 2/S /SUB 1/2/ electronic state in lithium borate glasses (1986)

The authors study lithium borate glasses containing groups IIB to VB metal oxides. Chemically pure reagents were used to synthesize the glasses which were subjected to gamma-rays at 77 and 300 K with doses of up to 100 kR. The EST spectra were recorded on a Varian E-12 spectrometer in the 3 cm CW frequency region with a 100 kHz magnetic field modulation. It was established that after gamma-irradiation at 77 and 300 K of the lithium borate glass system containing up to 10% of cadmium, tin, thalium, and lead oxides, additional ESR lines arise in the free electron g factor region. The authors have determined the missing ESR spectra for nonactivated lithium borate glasses by studying glasses with additions of Zn, Ge, and Sb oxides.
Association of myelodysplastic syndrome with CD5+, CD23+ monoclonal B-cell lymphocytosis (2012)

Made available in DSpace on 2015-06-14T13:45:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-12-01. Added 1 bitstream(s) on 2015-08-11T04:03:56Z : No. of bitstreams: 1 S1807-59322012001200022.pdf: 1794468 bytes, checksum: e1af871ffeb3d35d2e1c626755561a65 (MD5)
Arthroscopic stabilization for recurrent anterior shoulder dislocation: Results of 59 cases (1995)

Fifty-nine patients with recurrent anterior dislocation of the shoulder underwent the Morgan arthroscopic stabilization with transglenoidal suture of the inferior glenohumeral ligament. All patients were followed-up for an average of 49 months (range, 29 to 71 months). Using Rowe's scoring system, the overall objective results were disappointing. There were 33% excellent results, 9% good, 9% fair, and 49% poor. Twenty-six patients had a further dislocation, and 3 others had recurrent subluxation on average 13 months after the operation. The failures were associated with a preoperative clinical finding of inferior hyperlaxity as demonstrated by a positive sulcus sign, a preoperative radiological finding of a bony lesion on the anterior edge of the glenoid, or an arthroscopic finding of extended ligamentous lesions at the time of operation. The results of this study are clearly worse than those reported by other investigators. Direct comparison between the reported studies is problematic and is discussed. It was concluded that arthroscopic stabilization should only be performed by interested specialists as part of controlled clinical trials.
Response of Elevated Methylmalonic Acid to Three Dose Levels of Oral Cobalamin in Older Adults (2002)

Most Cbl-deficient older people require more than 100 microg of oral Cbl to normalize serum MMA, which is a larger dose than is available in most standard multivitamins and Cbl supplements.