gebhart/patrepeval huggingface dataset:
Water Jet Guided Laser Cutting of High Temperature Superconductors (2013)

In order to reduce their hysteresis losses, water jet guided laser cutting is applied to process 55m thin high temperature superconducting tapes. A 100W fiber coupled 532nm pulsed diode pumped solid state laser is employed in conjunction with a water jet guided cutting system to minimize the burr height and the heat affected zone along the cut kerf. To optimize the laser process a Design of Experiment approach is chosen with the input parameters being laser power, laser repetition rate, tape velocity and water pressure, respectively. To evaluate the improvement of the laser cutting process on the performance of the high temperature superconducting tapes in the AC modus, hysteresis losses of untreated and laser cut superconducting tapes are compared. As a result, we achieve burr free and clean cut kerfs that lead to critical current losses of 16% and hysteresis losses on the order of 48% to 70%, respectively.
Methods in diabetes research (1984)

Partial table of contents: Islet B-Cell Function in Human Subjects (W. Ward et al.) Assessment of Insulin Kinetics in Vivo (J. Radziuk and T. Morishima) Glucose Kinetics: Tracer Methods (E. Ferranninini et al.) Insulin-Degrading Activities in Human Tissues (A. Kitavchi and F. Stentz) Culture of Human Skin Fibroblasts (E. J. Moerman and Samuel Goldstein) Insulin Therapy: Closing the Loop with a Microprocessor (A. Albisser) Isolation of Canine Pancreatic Islets of Langerhans (R. Alejandro et al.) Optimizing the Frequency of Home Blood Glucose Monitoring (C. Peterson and L. Jovanovic) Modern Management of Diabetes and Pregnancy (L. Jovanovic and C. Peterson) Methods for Epidemiologic Investigation of Insulin-Diabetes Mellitus (R. LaPortre et al.)
Enhancement of MIS solar-cell ’’efficiency’’ by peripheral collection (1977)

Significant enhancement of the short-circuit current of small-area MIS and Schottky solar cells can occur by collection of carriers generated around the periphery of the cell. The amount of peripheral collection boost is predicted and studied experimentally. Very small-area cells (&lt;0.02 cm2) can have their short-circuit currents boosted by over 80%. For cells over 1 cm2, the increase is generally less than 10%. These results highlight the importance of basing efficiency measurements on the total front surface area of the cell.
Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine (2001)

DepoCyte is a slow-release formulation of cytarabine designed for intrathecal administration. The goal of this multi-centre cohort study was to determine the safety and efficacy of DepoCyte for the intrathecal treatment of neoplastic meningitis due to breast cancer. DepoCyte 50 mg was injected once every 2 weeks for one month of induction therapy; responding patients were treated with an additional 3 months of consolidation therapy. All patients had metastatic breast cancer and a positive CSF cytology or neurologic findings characteristic of neoplastic meningitis. The median number of DepoCyte doses was 3, and 85% of patients completed the planned 1 month induction. Median follow up is currently 19 months. The primary endpoint was response, defined as conversion of the CSF cytology from positive to negative at all sites known to be positive, and the absence of neurologic progression at the time the cytologic conversion was documented. The response rate among the 43 evaluable patients was 28% (CI 95%: 14-41%); the intent-to-treat response rate was 21% (CI 95%: 12-34%). Median time to neurologic progression was 49 days (range 1-515(+)); median survival was 88 days (range 1-515(+)), and 1 year survival is projected to be 19%. The major adverse events were headache and arachnoiditis. When drug-related, these were largely of low grade, transient and reversible. Headache occurred on 11% of cycles; 90% were grade 1 or 2. Arachnoiditis occurred on 19% of cycles; 88% were grade 1 or 2. DepoCyte demonstrated activity in neoplastic meningitis due to breast cancer that is comparable to results reported with conventional intrathecal agents. However, this activity was achieved with one fourth as many intrathecal injections as typically required in conventional therapy. The every 2 week dose schedule is a major advantage for both patients and physicians.
PARS PLANA VITRECTOMY FOR PERSISTENT, VISUALLY SIGNIFICANT VITREOUS OPACITIES (2000)

Purpose: To evaluate the role of vitrectomy in patients with persistent, visually disabling vitreous opacities. Methods: Six consecutive eyes of five men (age 58-66 years) with pseudophakia or aphakia and vitreous opacities resulting in visual symptoms for more than 1 year that underwent vitrectomy were retrospectively reviewed. Postoperative questionnaires regard-ing functional performance and quality-of-life issues were completed by the participants to assess subjective patient satisfaction. Results: Postoperative Snellen visual acuity was improved or equal to preoperative acuity in all cases (8-44 month follow-up) and there were no surgical complications. All patients expressed high satisfaction with overall visual function. Analysis of the National Eye Institute Visual Function Questionnaire-39 indicated that general vision, near activities, distance activities, mental health, role difficulties, and peripheral vision were significantly improved (P < 0.05) following surgical intervention. Conclusions: Vitrectomy may be indicated in a select group of patients with visually disabling vitreous floaters, although objective assessment of visual dysfunction from vitreous floaters requires further evaluation.
Autoantibodies Against Oxidized LDL Do Not Predict Atherosclerotic Vascular Disease in Non–Insulin-Dependent Diabetes Mellitus (1996)

Accelerated atherosclerosis in diabetes has been suggested as being due to an enhanced oxidative modification of LDL. We hypothesized that the titers of autoantibodies against oxidized LDL (oxLDL) may be increased in patients with non-insulin-dependent diabetes mellitus (NIDDM) and that they may contribute to various manifestations of atherosclerosis among such patients. In a 10-year follow-up study of 91 newly diagnosed NIDDM patients and 82 nondiabetic control subjects, autoantibodies against oxLDL (expressed as the ratio of autoantibodies against oxLDL and native LDL) were measured at baseline and after 10 years. Quantitative ultrasonography to examine the intimal-medial thickness of the common carotid artery (a morphological index of arterial wall injury) and carotid bifurcation was performed at the 10-year examination. The relationship of autoantibodies against oxLDL to the occurrence of cardiovascular death, fatal and nonfatal myocardial infarction, stroke, and any cardiovascular event as well as to the intimal-medial thickness of the common carotid artery and carotid bifurcation was evaluated. Associations between these autoantibodies and metabolic variables (fasting glucose, glycosylated hemoglobin, insulin, and serum lipids) in NIDDM patients were also examined. Autoantibodies against oxLDL did not differ between NIDDM and control subjects (NIDDM: baseline, 1.63 and 0.61 to 23.6; 10-year examination, 1.64 and 0.06 to 59.0; control group: baseline, 1.84 and 0.13 to 36.0; 10-year examination, 1.50 and 0.25 to 8.29; median and range, P = .62, baseline; P = .45, 10 year). In both groups, the titers of these autoantibodies measured at baseline and after 10 years significantly correlated with each other (r = .63 for the diabetic and r = .51 for the control group, respectively, P < .001 for each). The frequency of all cardiovascular events was markedly higher in the NIDDM group than in the control group, but autoantibodies against oxLDL had no significant association with any of these events, including cardiovascular mortality. At the 10-year examination the intimal-medial thickness of the common carotid artery (1.24 +/- 0.36 versus 1.06 +/- 0.30 mm, P = .002) and carotid bifurcation (2.11 +/- 0.73 versus 1.77 +/- 0.82 mm, P = .01) were greater in NIDDM patients than in control subjects, but autoantibodies did not show any association with the intimal-medial thicknesses in either the diabetic or control groups. Autoantibodies against oxLDL indicate the presence of oxidatively modified LDL in vivo, but their titers in the serum do not seem to associate with the excess cardiovascular mortality, morbidity, or intimal-medial thickness of the carotid artery.
Association of angiotensin II blockers with survival among men with prostate cancer: Results from CaPSURE. (2011)

4538 Background: Pre-clinical data suggests that angiotensin II blockade can modulate androgen receptor expression in prostate cell lines leading to inhibition of cell growth, but clinical data to validate this finding is lacking. With angiotensin II blockers (ABs) commonly used in cardiology to manage blood pressure & congestive heart failure, we utilized a longitudinal database to evaluate the association between ABs & outcomes among men with prostate cancer. Methods: The Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) database includes data on men who had undergone radical prostatectomy &/or radiation treatment, &/or androgen deprivation therapy for prostate cancer at 40 community practices & academic centers throughout the US since 1995. Use of cardiac medications including ABs (both angiotensin converting enzyme blockers & angiotensin receptor blockers), were ascertained based on patient reported data. The association of ABs with the risk of prostate cancer specific mortality (PCSM) & all cause mortality (ACM) was evaluated using competing risks & Cox multivariable regression models adjusting for known prognostic variables & possible confounders (including concurrent aspirin &/or statins use). Adjusted Hazard Ratios (AHRs) with 95% Confidence Intervals (CIs) & p values are reported. Results: The study cohort comprised 6,017 men with a median post-treatment follow up of 64 months. At diagnosis, the mean age was 65.6 years & median PSA was 6.4 ng/ml. 38% patients had low, 36% intermediate, & 26% high D'Amico clinical risk group. Men who were taking ABs had significantly lower risk of PCSM (AHR: 0.47, CI: 0.34-0.65, p <0.01), & ACM (AHR: 0.68, CI: 0.60-0.77, p<0.01), than those not taking ABs. The lower risk was observed for both low & intermediate/high risk disease. With concomitant use of ABs with aspirin and statins, the reduction in risk was slightly higher for both PCSM (AHR: 0.32, CI: 0.22-0.47, p <0.01) & ACM (AHR: 0.51, CI: 0.44-0.60, p<0.01). Conclusions: The study findings suggest that men taking angiotensin II blockers might have significantly lower risk of prostate cancer & all cause mortality. These novel findings should be explored further in additional studies.
Effect of carbon dioxide on growth of <i>Pseudomonas putida</i> ATCC 11172 on asparagine, citrate, glucose, and lactate in batch and continuous culture (1985)

The growth of Pseudomonas putida ATCC 11172 on L-asparagine, citrate, D-glucose, and L-lactate was followed in air and in 40% CO2 + air, using batch and carbon-limited continuous cultures. Batch cultures in air utilized a mixture of the carbon sources simultaneously. However, a change to 40% CO2 favoured the utilization of glucose. The maximum specific growth rate (mumax) in air was about 0.3 h-1 on glucose and 0.6 h-1 on the other carbon sources. In CO2, the mumax for glucose was reduced by 16% compared with almost 60-70% for the others. An order of preference for the different carbon sources in continuous cultures was determined by comparing the dilution rates at which the different carbon sources started to appear in the effluent. Glucose was the first compound to appear as the dilution rate increased (lowest preference when grown in air). In 40% CO2, the mumax for glucose was slightly higher than the others and the recorded preference for glucose in continuous culture was equal to that for citrate but was somewhat lower than that of lactate and asparagine. D-Gluconate and glucono-delta-lactone were produced as a step in the utilization of glucose. The D-gluconate production was enhanced by CO2.
A NUMERICAL MODEL OF DROPLET ENTRAINMENT FROM A CONTAINED OIL SLICK (1974)

A theoretical analysis of oil droplet entrainment from a contained oil slick moving relative to water has been performed as a function of relative oil-water velocity. A numerical method incorporating discrete vortices is used to calculate smooth stable headwave profiles at low velocities and unstable profiles at high velocities. An oil droplet formation criterion is formulated and applied to the numerically modeled headwave region. The computed critical velocity corresponding to the onset of significant droplet entrainment is in close agreement with recent laboratory measurements. The computed entrainment rates are in approximate agreement with experiment, but do not exhibit systematic variation with water current. Oil drop trajectories are calculated using realistic starting conditions, but the present work does not extend beyond the first intersection of the drop with the slick. Recommendations are given for extending the work to include: post-formation droplet dynamics, wave effects, turbulence effects, and barrier design changes.
Distensibility of Decellularized and Glutaraldehyde-Preserved Aortic Full Roots as Evaluated by Computed Tomography (2012)

Abstract The aortic root is a dynamic structure and its distensibility is considered an important factor in native and prosthetic heart valve function. Glutaraldehyde-preserved (GLUT) valves have limited durability possibly due to increased tissue stiffening. Decellularized deoxycholic acid-treated (DOA) valves exhibit excellent long-term performance in the pulmonary position in humans possibly due to preservation of valve tissue distensibility. We investigated aortic distensibility in DOA (n=8) and GLUT (n=3) aortic root prostheses in 60 kg pigs 2 weeks after orthotopic implantation. Five pigs served as controls. Using a dual source computed tomography scanner (Somatom Flash, Siemens Medical Solution, Forcheim, Germany) the cross sectional area at the level of Sinus of Valsalva (SoV), sino-tubular junction (STJ), and ascending aorta (AA), respectively, was measured in both diastole and systole. Distensibility was defined as the change in area from diastole (RR 95%) to systole (RR 15%). For assessment of the prosthetic- independent aortic distensibility we performed the same measurements in the descending aorta (AD) in all animals. Data were analyzed using students t-test and reported as a mean±SD. Native aortic distensibility was significant larger at the level of SoV (15.8%±4.9), STJ (46.7%±10.3), and AA (40.6%±9.0), compared with both DOA and GLUT aortic roots (p<0.05). No difference in distensibility between the DOA and GLUT aortic roots were observed: 8.8%±2.4 vs 6.2%±5.5 (SoV), 11.7%±3.0 vs 10.0%±7.1 (STJ), 14.9%±6.1 vs 11.8±1.7 (AA), and 15.6±1.5 vs 15.5±1.8 (DA) , respectively (p>0.05). There was no difference in mean distensibility between the three groups in the decending aorta. This is the first study to evaluate in-vivo distensibility of aortic root prostheses in vivo. Aortic root distensibility is reduced following implantation of DOA or GLUT prosthetic aortic valves. No difference was observed between DOA and GLUT valves. Long-term follow-up is needed in order to verify any changes in bioprosthetic aortic root distensibility over time.
Peptides from the calcitonin genes: molecular genetics, structure and function (1988)

Research Article| October 15 1988 Peptides from the calcitonin genes: molecular genetics, structure and function L H Breimer; L H Breimer *Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, U.K. Search for other works by this author on: This Site PubMed Google Scholar I MacIntyre; I MacIntyre †Royal Postgraduate Medical School, London W12 ONN, U.K. Search for other works by this author on: This Site PubMed Google Scholar M Zaidi M Zaidi †Royal Postgraduate Medical School, London W12 ONN, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1988) 255 (2): 377–390. https://doi.org/10.1042/bj2550377 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation L H Breimer, I MacIntyre, M Zaidi; Peptides from the calcitonin genes: molecular genetics, structure and function. Biochem J 15 October 1988; 255 (2): 377–390. doi: https://doi.org/10.1042/bj2550377 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1988 London: The Biochemical Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.
Role of P-Glycoprotein in Regulating Cilnidipine Distribution to Intact and Ischemic Brain (2013)

Cilnidipine is reported to show antihypertensive and neuroprotective actions in a rat brain ischemia model, but is barely distributed to normal brain, suggesting that its uptake into normal brain is inhibited by efflux transporter(s), such as P-glycoprotein (P-gp). Here, we investigated whether P-gp regulates the brain distribution of cilnidipine. Intracellular accumulation of cilnidipine was decreased in P-gp-overexpressing porcine kidney epithelial cells (LLC-GA5-COL150 cells) compared with control LLC-PK1 cells and the decrease was markedly inhibited by verapamil, a P-gp inhibitor. Further, cilnidipine concentration in the brain of P-gp knockout mice was significantly increased after cilnidipine administration, compared with that in wild-type mice. Moreover, when cilnidipine was administered to male spontaneously hypertensive rats (SHR) with tandem occlusion of the distal middle cerebral and ipsilateral common carotid artery, its concentration in the ischemic hemisphere was 1.6-fold higher than that in the contralateral hemisphere. This result was supported by visualization of cilnidipine distribution using matrix-assisted laser desorption/ionization-time of flight/mass spectrometry (MALDI-TOF/MS) imaging. Our results indicated that cilnidipine is normally excluded from the brain by P-gp-mediated efflux transport, but P-gp function is impaired in ischemic brain and consequently cilnidipine is distributed to the ischemic region.
De novo <i>KCNQ2</i> mutations in patients with benign neonatal seizures (2004)

Benign familial neonatal convulsions (BFNC) are characterized by unprovoked seizures during the first weeks of life with spontaneous remission after a few months. Mutations have been identified in the voltage-gated potassium ion channels KCNQ2 and KCNQ3. The authors performed a mutation analysis of KCNQ2 and KCNQ3 in six patients of whom four had no family history of neonatal seizures. The authors identified three KCNQ2 mutations in four patients that all arose de novo.
Relationship between deactivation of insulin-stimulated glucose transport and insulin dissociation in isolated rat adipocytes. (1980)

1) termination of the insulin signal on glucose transport can be separated from dissociation of insulin receptor complexes; 2) transport deactivation proceeds much more slowly than insulin dissociation and is dependent on some aspect of ongoing cellular metabolism.
Approche transnasale du systeme porte-hypophysaire chez le belier : application a l'etude des neuro-secretions. (1986)

National audience
Evaluation of Serology Results from Patients with Inflammatory Bowel Disease (2009)

Purpose: Seromarkers have demonstrated prognostic potential for inflammatory bowel disease (IBD) and may help differentiate IBD from other functional bowel disorders. Prometheus Laboratories has developed Prometheus® IBD Serology 7 (IBD7; Prometheus Laboratories Inc, San Diego, CA), which provides quantitative analysis of seromarkers with pattern-recognition algorithms for IBD prediction and differentiation. The IBD7 also tests for several antigens associated with IBD that are claimed to allow differentiation between ulcerative colitis (UC) and Crohn's disease (CD). Furthermore, Prometheus Laboratories states that the test can predict the phenotype, and thus the severity, of CD. The IBD7 claims a 92% overall accuracy, 93% sensitivity, 95% specificity, 96% positive predictive value (PPV), and 90% negative predictive value (NPV). Our objective was to evaluate the accuracy, sensitivity, and specificity of Prometheus IBD Serology 7 for the diagnosis of IBD and differentiation between CD and UC. Methods: This retrospective chart review at a community-based practice evaluated charts of patients with known or suspected IBD who underwent testing with the IBD7 serum assay between July 2006 and February 2009. Patients' final diagnosis was confirmed: (1) colonoscopy/ileoscopy with biopsy and (2) small bowel capsule endoscopy or computed tomographic enterography. Patients with equivocal or overlapping IBD were not included in the final analysis. Results: Diagnosis of IBD was confirmed in 68 of 111 patients (61%; 50 with CD, 18 with UC) included in the review. The chart review revealed a 63% sensitivity, 60% specificity, 72% PPV, and 51% NPV for the IBD7. The overall comparative accuracy in this population was 62% compared with 92% claimed by Prometheus Laboratories. Among the 68 confirmed IBD cases, 25 (37%) were incorrectly predicted; 19 (28%) were predicted as IBD7 negative (15 with CD, 4 with UC) and 6 (9%) were predicted to have CD but were confirmed to have UC. Of the 43 patients with no diagnostic evidence confirming IBD, IBD7 incorrectly identified 17 (40%) as seropositive. Conclusion: These data indicate that IBD serology requires continued investigation of its use as a diagnostic and prognostic tool. Studies in larger populations are needed to further validate this technology. Disclosure: Shafran - Consultant: Salix; Burgunder - none. This research was supported by an industry grant from Salix Pharmaceuticals, Inc.
12. Mimicking the events of menstruation in the murine uterus: a model for studying endometrial breakdown and repair (2003)

Reproduction, Fertility and Development is an international journal publishing original research , review and comment in the fields of reproduction and developmental biology in humans, domestic animals and wildlife
Tutorial on free-electron lasers (1984)

The free-electron laser (FEL) Mechanism is fundamentally related to microwave electron tubes and even to the atomic laser. In 1971, Madey1 showed how relativistic undulating electrons and open resonators could extend the tunable advantages of electron tubes to the optical regime.