gebhart/patrepeval huggingface dataset:
Gene expression-based predictors of chemotherapy response in basal-like breast cancer. (2012)

10500 Background: The Basal-like subtype is generally associated with high chemo-sensitivity, but not all tumors respond and/or benefit to the same extend. In this study, we sought to identify gene expression predictors of neoadjuvant chemotherapy sensitivity in Basal-like breast cancer. Methods: Expression of 542 genes was measured using the Nanostring nCounter platform from 69 FFPE pre-treated samples of the GEICAM/2006-03 phase II trial, which were treated with epirrubicin/cyclophosphamide followed by docetaxel+/-carboplatin. Research-based PAM50 and Claudin-low predictors were also evaluated. The association between response (Miller-Payne criteria) and gene/signature expression was assessed by multivariable ordinal logistic regression. Significant findings were evaluated in 109 independent triple-negative and Basal-like tumors treated with anthracycline/taxane-based chemotherapy (Hatzis et al.). Finally, interaction tests were performed to identify genes/signatures associated with carboplatin response. Results: In GEICAM/2006-03, 61/69 (88%) tumors were identified as Basal-like by PAM50. High correlation to the Basal-like centroid, or high expression of proliferation-related genes (i.e. FANCA), were found to be significantly associated with high chemo-sensitivity, whereas high expression of genes associated with mesenchymal/stem cell biological processes (i.e. SNAI1 and IL6) and/or luminal differentiation (i.e. MUC1 and FOXA1) were significantly associated with chemo-resistance; similar findings were observed in Hatzis et al. Finally, high expression of genes associated with proliferation/DNA-repair (i.e. ATR) and tight junctions (i.e. CLDN3/4/7) were found associated with carboplatin response, whereas expression of the Claudin-low signature was found associated with carboplatin resistance. Conclusions: High expression of Basal-like and/or proliferation-related genes and low expression of luminal/mesenchymal/stem cell-like biological processes were consistently identified as predictive of chemotherapy response. Our data suggests that gene expression profiling might help shed light into the biological and clinical heterogeneity of Basal-like breast cancer.
Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides (2015)

Oxidized l-glutathione was esterified to the tetra methyl ester using thionyl chloride in methanol solvent. Other alcohols were tested and the reaction progress was monitored via ESI-MS. This procedure proved to be compatible with other small peptides not containing serine and cysteine residues. In contrast to previously reported methods this procedure provided convenient access to esterified peptides requiring no purification, extended reaction times, or complicated reaction setups.
Cardiotoxicity of Anticancer Therapies (2015)

Cardiovascular diseases and cancer continue to remain major causes of mortality and morbidity. However, overall cancer death rates have declined 20% from their peak in 1991. These declines reflect changing patterns in smoking, prevention, earlier diagnosis, and better treatment options in chemotherapy. It is recognized that this improved survival with better cancer therapies has put patients at risk for cardiovascular disease later in life; this may be secondary to risk factors for developing cardiovascular disease or the effect of anticancer therapies. Earlier detection, identifying patients at risk of developing cardiotoxicity, and early institution of treatment are paramount to decreasing morbidity associated with cardiotoxicity. Adverse cardiac effects have been observed and reported with a wide variety of chemotherapeutic agents. Herein we review cardiac effects of some of the common agents used in oncology.
Kinetic and Pharmacological Properties of GABA<sub>A</sub>Receptors in Single Thalamic Neurons and GABA<sub>A</sub>Subunit Expression (2001)

Synaptic inhibition in the thalamus plays critical roles in sensory processing and thalamocortical rhythm generation. To determine kinetic, pharmacological, and structural properties of thalamic gamma-aminobutyric acid type A (GABA(A)) receptors, we used patch-clamp techniques and single-cell reverse transcriptase polymerase chain reaction (RT-PCR) in neurons from two principal rat thalamic nuclei-the reticular nucleus (nRt) and the ventrobasal (VB) complex. Single-channel recordings identified GABA(A) channels with densities threefold higher in VB than nRt neurons, and with mean open time fourfold longer for nRt than VB [14.6 +/- 2.5 vs. 3.8 +/- 0.7 (SE) ms, respectively]. GABA(A) receptors in nRt and VB cells were pharmacologically distinct. Zn(2+) (100 microM) reduced GABA(A) channel activity in VB and nRt by 84 and 24%, respectively. Clonazepam (100 nM) increased inhibitory postsynaptic current (IPSC) decay time constants in nRt (from 44.3 to 77.9 ms, P < 0.01) but not in VB. Single-cell RT-PCR revealed subunit heterogeneity between nRt and VB cells. VB neurons expressed alpha1-alpha3, alpha5, beta1-3, gamma2-3, and delta, while nRt cells expressed alpha3, alpha5, gamma2-3, and delta. Both cell types expressed more subunits than needed for a single receptor type, suggesting the possibility of GABA(A) receptor heterogeneity within individual thalamic neurons. beta subunits were not detected in nRt cells, which is consistent with very low levels reported in previous in situ hybridization studies but inconsistent with the expected dependence of functional GABA(A) receptors on beta subunits. Different single-channel open times likely underlie distinct IPSC decay time constants in VB and nRt cells. While we can make no conclusion regarding beta subunits, our findings do support alpha subunits, possibly alpha1 versus alpha3, as structural determinants of channel deactivation kinetics and clonazepam sensitivity. As the gamma2 and delta subunits previously implicated in Zn(2+) sensitivity are both expressed in each cell type, the observed differential Zn(2+) actions at VB versus nRt GABA(A) receptors may involve other subunit differences.
Evaluation of Additively Manufactured Single-Pass and Two-Pass Enhanced Microchannel Heat Sinks (2020)

Additive manufacturing is proving to be a viable manufacturing technique to fabricate complex structures as it opens up the design space by providing improved design freedom and reduced geometric restrictions. Further, it assures to provide benefit to the heat exchanger industry which relies on novel geometric features to enhance performance and efficiency. This paper explores the heat transfer and pressure drop performance of additively manufactured microchannel heat sinks. Two types of microchannel heat sinks were tested, namely, single-pass and two-pass microchannels with heat flux provided on the bottom wall. Additionally, the microchannel geometry was enhanced by incorporating periodic secondary flow passages with an aim to enhance fluid mixing and disrupt boundary layer development. The enhanced microchannel configurations featured the oblique fin and trapezoidal fin heat sinks. Enhanced microchannels showed superior performance both thermally and hydraulically with 100% increase in heat transfer performance with negligible gain in pressure drop over the baseline straight microchannel geometry. Moreover, the performance gain was more evident for the single-pass microchannels than the two-pass configuration, which showed tremendously high pressure drop due to increase in flow length. Results showed 30% reduction in the overall thermal resistance for a constant pressure drop for the enhanced microchannels in the single pass configuration.
Clinical efficacy and tolerability of extended‐release tolterodine and immediate‐release oxybutynin in Japanese and Korean patients with an overactive bladder: a randomized, placebo‐controlled trial (2003)

Tolterodine ER has similar efficacy but is better tolerated than oxybutynin IR in Japanese and Korean patients with OAB.
Relationship between magnitude estimation of resistive loads, inspiratory pressures, and the RREP P<sub>1</sub> peak (1999)

This study investigated the relationship among resistive load magnitude (DeltaR), the cortical evoked potential P(1) peak amplitude of the respiratory-related evoked potential (RREP), mouth pressure (Pm), esophageal pressure (Pes), transdiaphragmatic pressure (Pdi), and resistive load magnitude estimation (ME) in human subjects. The RREP, Pdi, Pes, Pm, and ME were recorded in response to three DeltaR values. The RREP was recorded from C(3) and C(4), referenced to the vertex C(Z). The group means of the Pdi, Pm, ME, and RREP P(1) amplitude increased with increases in the DeltaR. A log-log plot of the P(1) amplitudes showed a relationship with ME as did Pes, Pdi, and Pm. There were linear log-log relationships between C(Z)-C(3) P(1) amplitude, C(Z)-C(4) P(1) amplitude, and Pdi to ME. Pdi had a linear log-log relationship with C(Z)-C(3) and C(Z)-C(4). These results support the hypothesis that the estimated magnitude of the respiratory load is related to the P(1) amplitude of the RREP. Pm, Pes, and Pdi are mechanically related and correlated with the P(1) peak amplitude, suggesting that the mechanoreceptors mediating the P(1) peak of the RREP are activated by changes in mechanical forces related to the inspiratory pump.
Titanium NMR data for some titanium half-sandwich complexes bearing substituted cyclopentadienyl ligands (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTitanium NMR data for some titanium half-sandwich complexes bearing substituted cyclopentadienyl ligandsAndreas Hafner and Jun OkudaCite this: Organometallics 1993, 12, 3, 949–950Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/om00027a052https://doi.org/10.1021/om00027a052research-articleACS PublicationsRequest reuse permissionsArticle Views226Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 16895: Micrornas Control Endothelial Progenitor Senescence via Regulating Plk2 Expression (2011)

Background: With advancing age the regenerative properties of somatic stem cells deteriorate in part due to cellular senescence, eventually leading to the diminished repair capability. Endothelial progenitor cells (EPCs) play an important role in angiogenesis. Several miRNAs have been reported to be critical modulators for EPC plasticity. The aim of this study was to determine whether miRNAs regulated age-related senescence in lineage negative bone marrow cells (lin - BMCs) enriched for EPCs. Methods: Lin - BMCs were isolated from young (3-week-old) wild type (WT) and apoE -/- C57BL/6 mice and aged WT (29-month-old) and apoE -/- (12 month-old) mice. Global miRNA and gene expression profiling were analyzed. Results: Using genome-wide miRNA analysis, we found that miR-146a was increased 6.3-fold and 3.4-fold in aged WT and apoE -/- lin - BM cells, respectively, relative to their young counterparts. Microarray analysis showed that the Polo-like kinase 2 (Plk2), a member of the ‘polo’ family of serine/threonine protein kinases that are critical regulators of cell cycle progression or apoptosis, was decreased 18-fold in aged lin - BMC as compared to young cells. Luciferase assay showed miR-146a substantially inhibited WT Plk2-3’-UTR-luciferase activity in 293T cells, but not mutant Plk2-3’-UTR-luciferase reporter. Overexpression of lentiviral-derived miR-146a resulted in reduction of Plk2 expression, increased senescence-associated (SA) β-gal expression and decreased vascular tube formation in young EPCs, whereas miR-146a antagomir rejuvenated aged EPCs, causing increased Plk2 expression, decreased SA β-gal expression and enhanced vascular tube formation. Furthermore, knockdown of Plk2 by its siRNA resulted in increased senescence and diminished vascular tube formation. Conclusions: Using genomic and functional studies, we have discovered miR-146a controls age-associated EPC senescence via regulating Plk2 expression, thus negatively affecting their vascular repair capacity, which may impact atherogenesis. These findings advance our understanding of EPC aging and provide molecular targets for genetic modification to increase the therapeutic efficacy of EPCs in preventing and repairing vascular damage in atherosclerosis.
Novel Neo-Pentoxide Precursors for MOCVD Thin Films of TiO(2) and ZrO(2).[1] (1999)

Two novel Group IV precursors, titanium (IV) neo-pentoxide, [Ti({mu}-ONep)(ONep){sub 3}]{sub 2} (l), and zirconium (IV) neo-pentoxide, [Zr({mu}-ONep)(ONep){sub 3}]{sub 2} (2), were reported to possess relatively high volatility at low temperatures. These compounds were therefore investigated as MOCVD precursors using a lamp-heated cold-wall CVD reactor and direct sublimation without carrier gas. The ONep derivatives proved to be competitive precursors for the production of thin films of the appropriate MO{sub 2} (M = Ti or Zr) materials in comparison to other metallo-organic precursors. Compound 1 was found to sublime at 120 C with a deposition rate of {approximately}0.350 {mu}m/min onto a substrate at 330 C forming the anatase phase with < 1% residual C found in the final film. Compound 2 was found to sublime at 160 C and deposited as crystalline material at 300 C with < 1% residual C found in the final film. A comparison to standard alkoxide and {beta}-diketonates is presented where appropriate.
Molecular probes for the detection of Pneumocystis carinii (1990)

This paper reports the development of a molecular probe derived from cloned parasite deoxyribonucleic acid, combined with detection by in situ hybridization or by the polymerase chain reaction, for the diagnosis of Pneumocystis carinii infection.
Longitudinal structural relaxation of glass-forming epoxy oligomer (1998)

The glass transition process of a common epoxy oligomer (diglycidyl ether of bisphenol A) has been characterized by Brillouin scattering (GHz range) and ultrasonic pulse spectroscopy (MHz range). As the temperature decreases, longitudinal wave velocity rapidly increased. It showed a large frequency dispersion at temperatures higher than the thermodynamical glass transition temperature (Tg). At Tg, velocity changes showed a clear kink. Wave attenuation also showed a peak of the main (alfa) relaxation at temperatures higher than Tg. The peak temperature shifted to lower temperatures in the MHz range, following the VFT type relaxation behavior, which is very common in the main relaxation. The velocities, however, still showed a clear frequency dispersion at temperatures lower than Tg. Because the main relaxation usually results from a large-scale conformational rearrangement of the polymer chain backbone, the effect of this relaxation seems to be neglected at these temperatures. Taking into account the frequency changes of attenuation peak widths, the effect of other subrelaxations at lower temperatures is discussed. These results are not in contradiction with the acoust-optic dispersion measurements of this oligomer [Kruger et al., Phase Transition (to be published)].
Adaptive Neurocontrol of Heat Exchangers (2001)

This paper investigates the use of adaptive artificial neural networks (ANNs) to control the exit air temperature of a compact heat exchanger. The controllers, based on an internal model control scheme, can be adapted on-line on the basis of different performance criteria. By numerical simulation a methodology by which the weights and biases of the neural network are modified according to these criteria was developed. An ANN controller for an air-water compact heat exchanger in an experimental facility is then implemented. The parameters of the neural net are modified using three criteria: minimization of target error, stabilization of the closed-loop performance of the controller, and minimization of a performance index that we have taken to be the energy consumption. It is shown that the neural network is able to control the air exit temperature in the heat exchanger. The neurocontroller is able to adapt to major structural changes in the system as well as to simultaneously minimize the amount of energy used.
Electronic structure and properties of epitaxial Fe on Cu(100): Theory and experiment (1986)

Results of a combined experimental-theoretical study of the electronic structures and properties of epitaxial Fe on Cu(100) are reported. Angle-resolved photoelectron spectroscopy is used to determine the electronic structure of one, two, and four layers of epitaxial Fe on Cu(100). The experimentally determined two-dimensional energy bands of p(1\ifmmode\times\else\texttimes\fi{}1) Fe mono and bilayers verify predictions of local spin-density full potential linearized augmented plane-wave calculations. Changes in electronic properties with coverage and the evolution of the bulk electronic structure of the substrate-stabilized fcc iron are described.
Reports of TAPPI 99 Joint Conference (1999)

TAPPI 99 Joint Conference was held in Atlanta, USA, from February 28-March 4, 1999. More than 10, 000 attendees participated in Papermakers Conference, Process Control, Electrical & Information Conference, Recycling Symposium, Effective Use of Capital Hot Topic Symposium and the 1999 TAPPI Annual Meeting. The Conferences featured 500 exhibitors in the huge exhibit space. From the 150 posters, round table discussions, and oral presentations, I would like to introduce several interesting topics from the Recycling Symposium in this report.
Finite Element Simulation of the Compaction and Springback of Alumix 321 PM Alloy (2015)

A finite element simulation of the compaction and springback of an aluminum-based powder metallurgy alloy (Alumix 321) was developed and validated using the LS-DYNA hydrocode. The present work aims to directly address the current scarcity of modeling works on this popular alloy system. The Alumix 321 constitutive material parameters are presented. The model can predict the results of single-action compaction as well as the amount of springback experienced by a compact upon ejection from the die. The model has been validated using a series of experiments including powder compaction, optical densitometry, and the creation of a compaction curve.
Numerical Solutions of Electromagnetic Boundary Value Problems by Means of the Asymptotic Anticipation Method (1968)

A method for improving the accuracy of approximate numerical solutions of doubly infinite sets of simultaneous linear algebraic equations is presented. The method is based on using prior information about the asymptotic behavior of the solution to anticipate the dominant contribution of the terms beyond the truncation limit imposed by the restriction of numerical solutions to finite matrix equations. Such information is shown to be available for the sets of equations which are frequently used in electromagnetic boundary value problems. The advantages and disadvantages of this method are discussed and then illustrated via results for the well‐known problem of scattering from a planar grating.
ChemInform Abstract: Design and Synthesis of Novel Benzofurans as a New Class of Antifungal Agents Targeting Fungal N‐Myristoyltransferase. Part 2. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effect of local cooling on short-term, intense exercise (2013)

The widespread belief that local cooling impairs short-term, strenuous exercise performance is controversial. Eighteen original investigations involving cooling before and intermittent cooling during short-term, intensive exercise are summarized in this review. Previous literature examining short-term intensive exercise and local cooling primarily has been limited to the effects on muscle performance immediately or within minutes following cold application. Most previous cooling studies used equal and longer than 10 minutes of pre-cooling, and found that cooling reduced strength, performance and endurance. Because short duration, high intensity exercise requires adequate warm-up to prepare for optimal performance, prolonged pre-cooling is not an effective method to prepare for this type of exercise. The literature related to the effect of acute local cooling immediately before short duration, high intensity isotonic exercise such as weight lifting is limited. However, local intermittent cooling during short-term, high intense exercise may provide possible beneficial effects; first, by pain reduction, caused by an "irritation effect" from hand thermal receptors which block pain sensation, or second, by a cooling effect, whereby stimulation of hand thermal receptors or a slight lowering of blood temperature might alter central fatigue.
[Neuro-endocrine tumors and von Hippel-Lindau disease. 3 cases]. (1999)

The diagnosis of HVL disease should be suggested in case of familial pheochromocytoma and/or bilateral localizations, but also in case of neuroendocrine tumors of the pancreas associated with another cardinal lesion of the disease. Early screening and treatment of this potentially fatal disease is essential.
NPOx Decontamination System (2002)

The nitric acid/potassium permanganate/oxalic acid (NPOx) Phase II system is being prepared for remote operation at the Idaho National Engineering and Environmental Laboratory (INEEL). Several tests have been conducted to prepare the system for remote operation. This system performs very well with high decontamination efficiencies and very low quantities of waste generated during decontamination.
Swiss Blood Stem Cells: More than Just a Registry (2011)

Swiss Transfusion SRC, division Swiss Blood Stem Cells (SBSC), is an important national organization for all matters relating to blood stem cells. Not only has its name changed several times over the years but also its role has developed steadily and today goes beyond registry alone. For example, on order of and in close collaboration with transplant doctors, the organization searches for suitable donors worldwide. Searching for unrelated donors for Swiss patients and organizing the deliveries of the transplant tissues for Swiss and foreign patients are the most time-consuming procedures at SBSC. Additionally, the organization pays special attention to the problem of donor follow-up. Here it has made important contributions to the field of data collection (minimal data set) and helped to strengthen international coordination. As of January 2011, the organization has a new structure, because it has joined forces with the SRC Blood Transfusion Service. The new organization will be called Swiss Transfusion SRC, but SBSC remains as a main operational unit of the new organization. In 2009, SBSC implemented a successful new strategy to increase the numbers of donors: donors can now register online. This step led to a remarkable increase of donor numbers from 2009 to 2010.