gebhart/patrepeval huggingface dataset:
Synthesis and Hydrolysis of Oligodeoxyribonucleotides Containing 2-Aminopurine (1996)

A new method is reported for the synthesis of oligodeoxyribonucleotides containing 2-aminopurine residues at selected sites. This method involves protection of the 2-aminopurine ribonucleoside, reduction to the deoxyribonucleoside and standard preparation of the 5'-0- (4,4'-dimethoxytrityl)-3'-O-(2-cyanoethyl)-N,N- diisopropylphosphoramidite. The 2-aminopurine phosphoramidite prepared by this method couples with high efficiency and is stable under standard automated synthesis conditions. The presence and location of the 2-aminopurine residue is easily verified by treatment of the oligodeoxyribonucleotide with hot piperidine. The mechanism for selective hydrolysis of the 2-aminopurine residue in alkaline solution is predominantly direct cleave of the glycosidic bond.
Ruminal hydrogenation of cholesterol (1978)

Cholesterol was hydrogenated by anaerobic incubation with sheep rumen fluid for periods up to 20 hr. The principal product of cholesterol hydrogenation was identified as coprostanol. Cholesterol could be protected against in vitro ruminal hydrogenation by encapsulation in a matrix of formaldehyde-treated casein. Formaldehyde-treated casein-cholesterol preparations were also shown to be protected against hydrogenation in vivo and, when supplements containing 1 g per day of protected or unprotected cholesterol were fed to sheep over a period of 8-9 weeks, there were marked differences in the plasma cholesterol response. The plasma cholesterol of the sheep fed protected cholesterol increased by at least 60%. The plasma cholesterol of the sheep fed unprotected cholesterol also tended to increase during the first 5 weeks of supplementation but thereafter declined to almost control levels at 8 weeks.
Parametric-Resonance Ionization Cooling and Reverse Emittance Exchange for Muon Colliders (2006)

Two new ideas are being developed to reduce the transverse emittance of muon beams in order to increase the luminosity of muon colliders. The first idea involves driving a 12‐integer parametric resonance in a beam line or ring such that particle motion becomes hyperbolic, where xx′=constant. With the proper phase of the resonance driving term, particles move to larger and larger x′ and smaller and smaller x at the position of a thin wedge absorber. The usual mechanism of ionization cooling reduces or constrains the excursion in x′ while the dynamics of the resonance reduces the spread of x. The second idea takes advantage of the large reduction of relative momentum spread with increasing momentum in going from a few hundred MeV/c where the beam is cooled to a few TeV/c for an energy frontier collider. In this case we can use thin wedge absorbers to exchange the transverse and longitudinal emittances to make the transverse emittance smaller. These two ideas depend on careful control of the lattice functions and corrections for chromatic and spherical aberrations. We discuss these ideas and their potential luminosity implications considering the limitations of aberration corrections and of space charge effects.
Health data use, stewardship, and governance: ongoing gaps and challenges: a report from AMIA's 2012 Health Policy Meeting (2013)

Large amounts of personal health data are being collected and made available through existing and emerging technological media and tools. While use of these data has significant potential to facilitate research, improve quality of care for individuals and populations, and reduce healthcare costs, many policy-related issues must be addressed before their full value can be realized. These include the need for widely agreed-on data stewardship principles and effective approaches to reduce or eliminate data silos and protect patient privacy. AMIA's 2012 Health Policy Meeting brought together healthcare academics, policy makers, and system stakeholders (including representatives of patient groups) to consider these topics and formulate recommendations. A review of a set of Proposed Principles of Health Data Use led to a set of findings and recommendations, including the assertions that the use of health data should be viewed as a public good and that achieving the broad benefits of this use will require understanding and support from patients.
Large Increases in Photocurrents and Solar Conversion Efficiencies by UV Illumination of Dye Sensitized Solar Cells (2001)

Ultraviolet (UV) treatment of dye sensitized solar cells (DSSCs) containing tetra-n-butylammonium iodide electrolyte increases photocurrents dramatically. The effect remains after cessation of UV illumination. Depending upon the photosensitizing dye, the increase in photocurrent can be as much as 2 orders of magnitude. The photocurrent increase more than compensates for slight decreases in photovoltage and fill factor, resulting in overall solar conversion efficiency increases up to 45× for some dyes. The primary effect of the UV treatment appears to be a positive shift in the conduction band of the nanocrystalline titanium dioxide, which promotes electron injection from the dye. The dyes and the solar cells are both found to be stable to this treatment. This effect offers the ability to tune the properties of the semiconductor to match the requirements of a specific dye, thus providing a versatile analytical tool for characterizing DSSCs while also enabling the use of new classes of sensitizing dyes. This letter describes the UV effect and summarizes the results of its application to a number of perylene-based sensitizers and two ruthenium bipyridyl sensitizers.
ChemInform Abstract: ORGANOMETALLIC CHEMISTRY OF HETEROCYCLES. 4. REACTIONS OF CYCLOALKENO‐1,2,3‐SELENADIAZOLENE WITH TRANSITION METAL CARBONYL COMPOUNDS (1980)

Abstract Bei der Umsetzung der Cycloalkenoselenadiazole (I) mit Nonacarbonyldieisen bei Raumtemp. in Hexan entstehen die beiden an einer Al 2 O 3 ‐Säule leicht trennbaren Komplexe (II) und (III) in guten Ausb. (nicht näher angegeben).
Apports protéiques et situations d'agression (1995)

Résumé * INRA, centre de Theix Diffusion du document : INRA, centre de Theix
Stabilities Studies of Formulations Containing Eucalyptus Oil (2013)

Stability testing of herbal products is a challenging task, because the entire herb or herbal product is regarded as the active substance, regardless of whether constituents with defined therapeutic activity are known. The objective of a stability testing is to provide evidence on how the quality of the herbal products varies with the time under the influence of environmental factors such as temperature, light, oxygen, moisture, other ingredient or excipient in the dosage form, particle size of drug, microbial contamination, trace metal contamination, leaching from the container, etc. and to establish a recommended storage condition, retest period and shelflife. The present study is reported on Eucalyptus oil which is obtained from the fresh leaves of Eucalyptus globules. The present research work deals with the Accelerated stability studies of three ointments containing Eucalyptus oil (i.e Mixagrip ointment, Helpex Effect ointment and Combigrip ointment) by using Gas chromatography through various stability parameters like physical, chemical and microbiological. © 2011 IGJPS. All rights reserved.
Atmospheric Chemistry of HFE-7100 (C<sub>4</sub>F<sub>9</sub>OCH<sub>3</sub>):  Reaction with OH Radicals, UV Spectra and Kinetic Data for C<sub>4</sub>F<sub>9</sub>OCH<sub>2</sub>· and C<sub>4</sub>F<sub>9</sub>OCH<sub>2</sub>O<sub>2</sub>· Radicals, and the Atmospheric Fate of C<sub>4</sub>F<sub>9</sub>OCH<sub>2</sub>O· Radicals (1997)

Relative rate techniques were used to estimate k(OH+HFE-7100) ≈ 1.2 × 10-14 cm3 molecule-1 s-1 at 295 K leading to an estimate of ≈5 years for the atmospheric lifetime of HFE-7100 (HFE = hydrofluoroether). Pulse radiolysis transient UV absorption spectroscopy was used to study the ultraviolet absorption spectra and kinetics of C4F9OCH2 and C4F9OCH2O2 radicals at 296 K. At 300 nm σ(C4F9OCH2) = (5.80 ± 0.76) × 10-19 and at 250 nm σ(C4F9OCH2O2) = (2.24 ± 0.24) × 10-18 cm2 molecule-1. Both UV spectra showed two absorption maxima, one below 230 nm and one at 290 nm. Rate constants for the self-reactions of C4F9OCH2 and C4F9OCH2O2 radicals, the reaction of C4F9OCH2 radicals with O2, and the reactions of C4F9OCH2O2 radicals with NO and NO2 were (3.5 ± 0.8) × 10-11, (1.35 ± 0.17) × 10-11 (uncorrected for possible secondary chemistry), (2.5 ± 0.5) × 10-12, (8.5 ± 2.5) × 10-12, and (8.8 ± 1.8) × 10-12 cm3 molecule-1 s-1, respectively. Using a pulse radiolysis method we measured k(F+HFE-7100) = (1.6 ± 0.6) × 10-11 cm3 molecule-1 s-1. Using a Fourier transform infrared spectroscopic technique rate, constants for the reaction of F and Cl atoms with HFE-7100 and Cl atoms with C4F9OC(O)H were determined to be (1.3 ± 0.3) × 10-11, (9.7 ± 1.4) × 10-14, and (1.6 ± 0.7) × 10-14 cm3 molecule-1 s-1, respectively. Finally, it was determined that the sole atmospheric fate of C4F9OCH2O· radicals is reaction with O2 to give C4F9OC(O)H (perfluorobutyl formate). The results are discussed with respect to the atmospheric chemistry of HFE-7100.
Chemerin Peptides Promote Phagocytosis in a ChemR23- and Syk-Dependent Manner (2010)

Abstract Chemerin peptides represent a recently identified component of the endogenous anti-inflammatory network that act via the G protein-coupled receptor ChemR23. The role of the chemerin peptide/ChemR23 pathway in phagocytosis, the clearance of apoptotic cells (efferocytosis), and the resolution of inflammation is unknown. In this article, we report that low picomolar concentrations of the chemerin peptide chemerin15 (C15) enhance macrophage (MΦ) phagocytosis of microbial particles and apoptotic cells by up to 360% in vitro. These prophagocytic effects of C15 are significantly impaired in ChemR23−/− MΦs and are associated with increased actin polymerization and localization of F-actin to the phagocytic cup. Importantly, pharmacological inhibition of Syk activity completely abrogates the prophagocytic activities of C15 and associated changes in actin polymerization and phagocytic cup formation, suggesting that C15 promotes phagocytosis by facilitating phagocytic cup development in a Syk-dependent manner. During peritoneal inflammation, C15 administration (8 pg/mouse) enhances microbial particle clearance and apoptotic neutrophil ingestion by MΦs in wild-type but not ChemR23−/− mice, such that levels of apoptotic and necrotic cells at the inflammatory site are profoundly reduced. In contrast, neutralization of endogenous chemerin species during peritoneal inflammation significantly impairs MΦ ingestion of apoptotic neutrophils and zymosan. Our data identify a key role of the chemerin peptide/ChemR23 axis in the efficient clearance of foreign material, efferocytosis, and, hence, the resolution of inflammation. Manipulation of the chemerin peptide/ChemR23 axis may represent a novel therapeutic approach for the treatment of inflammatory pathologies, especially if failure to efficiently clear phagocytic targets has been implicated in their pathogenesis.
Inserción velamentosa de cordón y desaceleración variable en el monitoreo cardiaco fetal (2013)

La inserción velamentosa de cordón es una patología inusual de la inserción de cordón, el cual carece de gelatina de Wharton. Presentamos el caso de una paciente que ingresó con diagnóstico presuntivo de corioamnionitis que presentó desaceleración variable (DIP III) durante el monitoreo fetal. La paciente fue operada sin estar en labor de parto y con membranas integras; el diagnóstico post cesárea fue inserción velamentosa de cordón.
A new principle for fast Fourier transformation (1976)

An alternative form of the fast Fourier transform (FFT) is developed. The new algorithm has the peculiarity that none of the multiplying constants required are complex-most are pure imaginary. The advantages of the new form would, therefore, seem to be most pronounced in systems for which multiplication are most costly.
Integration of GPS Receivers into Existing Inertial Navigation Systems (1988)

Many inertial navigation systems of both platform and ring laser strapdown types are currently in service. This paper discusses the possibility and desirability of incorporating a small GPS receiver in these systems. Advances in technology such as microprocessors, gate arrays, and surface mount devices allow the existing INS electronics to be replaced in a reduced volume. The remaining space in many cases is sufficient to permit the insertion of a small GPS receiver. Locating the GPS receiver in an inertial navigation system (INS) solves many of the usual system integration problems. Tight coupling between the GPS and INS can be achieved since data latency is minimized and well controlled. In such a configuration, rate aiding of the GPS is easily achieved. This approach also leads to greater flexibility and enhanced overall performance since all GPS and INS data are simultaneously available. While not providing the ultimate in redundancy, the integrated INS/GPS approach does offer greater simplicity with enhanced performance. This discussion primarily focuses on military systems. Nevertheless, the proposed techniques also are applicable to commercial units.
Cybersickness Following Repeated Exposure to DOME and HMD Virtual Environments (2011)

Virtual environments (VE) offer unique training opportunities, including training astronauts to preadapt them to the novel sensory conditions of microgravity. However, one unresolved issue with VE use is the occurrence of cybersickness during and following exposure to VE systems. Most individuals adapt and become less ill with repeated interaction with VEs. The goal of this investigation was to compare motion sickness symptoms (MSS) produced by dome and head-mounted (HMD) displays and to examine the effects of repeated exposures on MSS. Sixty-one subjects participated in the study. Three experimental sessions were performed each separated by one day. The subjects performed a navigation and pick and place task in either a dome or HMD VE. MSS were measured using a Simulator Sickness Questionnaire before, immediately after, and at 1, 2, 4 and 6 hours following exposure to the VEs. MSS data were normalized by calculating the natural log of each score and an analysis of variance was performed. We observed significant main effects for day and time and a significant day by time interaction for total sickness and for each of the subscales, nausea, oculomotor and disorientation. However, there was no significant main effect for device. In conclusion, subjects reported a large increase in MSS immediately following exposure to both the HMD and dome, followed by a rapid recovery across time. Sickness severity also decreased over days, which suggests that subjects become dual-adapted over time making VE training a viable pre-flight countermeasure for space motion sickness.
Deep brain stimulation of the cerebellum for poststroke motor rehabilitation: from laboratory to clinical trial (2018)

Ischemic stroke is a leading cause of disability worldwide, with profound economic costs. Poststroke motor impairment is the most commonly encountered deficit resulting in significant disability and is the primary driver of stroke-associated healthcare expenditures. Although many patients derive some degree of benefit from physical rehabilitation, a significant proportion continue to suffer from persistent motor impairment. Noninvasive brain stimulation, vagal nerve stimulation, epidural cortical stimulation, and deep brain stimulation (DBS) have all been studied as potential modalities to improve upon the benefits derived from physical therapy alone. These neuromodulatory therapies aim primarily to augment neuroplasticity and drive functional reorganization of the surviving perilesional cortex. The authors have proposed a novel and emerging therapeutic approach based on cerebellar DBS targeted at the dentate nucleus. Their rationale is based on the extensive reciprocal connectivity between the dentate nucleus and wide swaths of cerebral cortex via the dentatothalamocortical and corticopontocerebellar tracts, as well as the known limitations to motor rehabilitation imposed by crossed cerebellar diaschisis. Preclinical studies in rodent models of ischemic stroke have shown that cerebellar DBS promotes functional recovery in a frequency-dependent manner, with the most substantial benefits of the therapy noted at 30-Hz stimulation. The improvements in motor function are paralleled by increased expression of markers of synaptic plasticity, synaptogenesis, and neurogenesis in the perilesional cortex. Given the findings of preclinical studies, a first-in-human trial, Electrical Stimulation of the Dentate Nucleus Area (EDEN) for Improvement of Upper Extremity Hemiparesis Due to Ischemic Stroke: A Safety and Feasibility Study, commenced in 2016. Although the existing preclinical evidence is promising, the results of this Phase I trial and subsequent clinical trials will be necessary to determine the future applicability of this therapy.
Sideband frequency response function based damage identification of rotor system with open cracks (2014)

This paper develops a new vibration based damage detection method to identify the location and severity of structural damage of periodically time-varying systems. The frequency response function (FRF) shifts induced by cracks are utilized to detect the location, depth and orientation angle of open transverse cracks on a shaft-disk system. The dynamical model of system is built based on the Lagrange principle and the assumed mode method while the crack model for periodically time-varying systems is based on the fracture mechanics. This method provides the advantages of arbitrary interrogation frequency and multiple inputs/outputs which greatly enriches the dataset for damage identification. The method is synthesized via harmonic balance and numerical examples for a shaft/disk system to demonstrate the effectiveness in detecting both location and severity of the structural damage.
Mass Spectrometric Studies of the Thermal Decomposition of Poly(carbon monofluoride) (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMass Spectrometric Studies of the Thermal Decomposition of Poly(carbon monofluoride)A. K. Kuriakose and J. L. MargraveCite this: Inorg. Chem. 1965, 4, 11, 1639–1641Publication Date (Print):November 1, 1965Publication History Published online1 May 2002Published inissue 1 November 1965https://pubs.acs.org/doi/10.1021/ic50033a023https://doi.org/10.1021/ic50033a023research-articleACS PublicationsRequest reuse permissionsArticle Views181Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Multichannel Microfluidic Sensor That Detects Anodic Redox Reactions Indirectly Using Anodic Electrogenerated Chemiluminescence (2003)

Here, we describe a new approach for detecting redoxactive targets by electrochemical oxidation and reporting their presence by electrogenerated chemiluminescence (ECL) based on electrochemical oxidation of Ru(bpy)3(2+) (bpy = 2,2'-bipyridine) and tripropylamine (TPA). This new strategy, which complements our previous reports of using ECL to signal the presence of targets undergoing electrochemical reduction, takes advantage of many of the attractive attributes of microfluidic-based electrochemical cells. These attributes include close proximity of multiple flow channels and electrodes, ability to move reagents through channels under laminar flow conditions, and the capacity to precisely place device components relative to one another using photolithography. Specifically, the microfluidic electrochemical sensor described here consists of three channels. The analyte and ECL reporting cocktail flow through separate channels, but they share a common anode. The cathode resides in a channel containing a sacrificial reductant. In this configuration, the target analyte competes with Ru(bpy)3(2+) and TPA to provide electrons for the reductant. Accordingly, in this competitive assay approach, the presence of the analyte is signaled as a lowering of the ECL intensity. In this report, the device performance characteristics are reported, and the detection of both ferrocyanide and dopamine is demonstrated at micromolar concentrations.
Useful groups for trellis codes (2002)

We show how to construct and classify inequivalent homogeneous rate-k/k+1 trellis codes using principles of computational group theory. Given a complete classification of useful trellis structures, trellis codes based on groups are no more difficult to construct than trellis codes based on binary fields.
Correlation and path coefficient analysis for various quantitative traits in chickpea (Cicer arietinum L.). (2012)

The present studies were conducted in the field of the department of Plant Breeding
and Genetics, University of Agriculture, Faisalabad, during the crop season 2008-2009. The
higher estimate of heritability was found for plant height while genetic advance for number
of pods per plant. Correlation studies showed that biomass per plant, number of pods per
plant, number of secondary branches per plant, number of seeds per pod and 100-seed
weight were positive and significant at genotypic level but positive and highly significant at
phenotypic level. Higher direct effects were found for number of days taken to flowering
and maturity, biomass per plant and 100-seed weight on grain yield per plant. It was
concluded that selection can be made on the basis of number of grains per plant, 100-seed
weight and grain yield per plant.