gebhart/patrepeval huggingface dataset:
Decreased Central μ-Opioid Receptor Availability in Fibromyalgia (2007)

The underlying neurophysiology of acute pain is fairly well characterized, whereas the central mechanisms operative in chronic pain states are less well understood. Fibromyalgia (FM), a common chronic pain condition characterized by widespread pain, is thought to originate largely from altered central neurotransmission. We compare a sample of 17 FM patients and 17 age- and sex-matched healthy controls, using mu-opioid receptor (MOR) positron emission tomography. We demonstrate that FM patients display reduced MOR binding potential (BP) within several regions known to play a role in pain modulation, including the nucleus accumbens, the amygdala, and the dorsal cingulate. MOR BP in the accumbens of FM patients was negatively correlated with affective pain ratings. Moreover, MOR BP throughout the cingulate and the striatum was also negatively correlated with the relative amount of affective pain (McGill, affective score/sensory score) within these patients. These findings indicate altered endogenous opioid analgesic activity in FM and suggest a possible reason for why exogenous opiates appear to have reduced efficacy in this population.
The Linked Data Mining Challenge 2015 (2015)

The 2015 edition of the Linked Data Mining Challenge, con- ducted in conjunction with Know@LOD 2015, has been the third edition of this challenge. This year's dataset collected movie ratings, where the task was to classify well and badly rated movies. The solutions submitted reached an accuracy of almost 95%, which is a clear advancement over the baseline of 60%. However, there is still headroom for improvement, as the majority vote of the three best systems reaches an even higher accuracy.
Lunar Orbiter mission design. (1969)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Seismic Response Evaluation of RC Tower Connected to Short Rigid Buildings (2011)

In urban construction with the presence of tall buildings adjacent to short buildings, civil engineers have tried to connect low-rise rigid buildings to tall buildings in order to enhance the rigidity of the towers and decrease seismic response induced by earthquake excitation. From recent developments in earthquake energy dissipation systems, the application of viscous dampers for coupling of parallel and adjacent buildings to reduce earthquake effect has been considered by civil engineers, and many investigations have been conducted. In the present study an attempt has been made to evaluate the effect of connecting reinforced concrete towers to short rigid building through viscous damper devices. For this purpose, a 10-story RC tower connected to two short RC buildings by viscous damper was modeled and analyzed under Elcentro (1940) earthquake record excitation by using the finite element technique. In addition, the effect of various viscous damper damping coefficients on seismic response of the tower was evaluated by analyzing the aforementioned tower with various damper damping coefficient to the short building. The results showed improvement of seismic response of the tall building which was supported by short RC buildings through viscous damper device during earthquake. Moreover by increasing damper damping coefficient response of the tower structure the displacement was effectively reduced.
PoP prototyping by determination of matter transport effects (2010)

The assemblies “PoP” (Package-on-Package) can significantly increase the integration density of microelectronic circuits and systems, by vertically combining discrete semiconductor elements. Related to reliability especially migration phenomena, which are investigated here by simulation and measurements, become more important as the dimension of bumps decreases. To explore the influence of migration phenomena to the lifetime of PoPs a test card for current stress tests was designed. Furthermore, an exploration IMC growth was carried out. For a detailed interpretation of the test results FEM simulations with ANSYS <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> were performed. Finally, the results were used to predict the lifetime of the daisy chains and to calculate the activation energy for the IMC formation.
Structure of the spiramycins (foromacidines) and their relationship with the leucomycins and carbomycins (magnamycins) (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of the spiramycins (foromacidines) and their relationship with the leucomycins and carbomycins (magnamycins)Satoshi Omura, Akira Nakagawa, Masaru Otani, Toju Hata, Haruo Ogura, and Kimio FuruhataCite this: J. Am. Chem. Soc. 1969, 91, 12, 3401–3404Publication Date (Print):June 1, 1969Publication History Published online1 May 2002Published inissue 1 June 1969https://pubs.acs.org/doi/10.1021/ja01040a069https://doi.org/10.1021/ja01040a069research-articleACS PublicationsRequest reuse permissionsArticle Views117Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Measurements of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>t</mml:mi><mml:mover accent="true"><mml:mi>t</mml:mi><mml:mo stretchy="false">¯</mml:mo></mml:mover></mml:math> differential cross-sections of highly boosted top quarks decaying to all-hadronic final states in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>p</mml:mi><mml:mi>p</mml:mi></mml:math> collisions at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msqrt><mml:mrow><mml:mi>s</mml:mi></mml:mrow></mml:msqrt><mml:mo>=</mml:mo><mml:mn>13</mml:mn><mml:mtext> </mml:mtext><mml:mtext> </mml:mtext><mml:mi>TeV</mml:mi></mml:mrow></mml:math> using the ATLAS detector (2018)

Measurements are made of differential cross-sections of highly boosted pair-produced top quarks as a function of top-quark and t t system kinematic observables using proton-proton collisions at a center-ofmass energy of ffiffi ffi s p 13 TeV. The data set corresponds to an integrated luminosity of 36.1 fb -1 , recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Events with two largeradius jets in the final state, one with transverse momentum p T > 500 GeV and a second with p T > 350 GeV, are used for the measurement. The top-quark candidates are separated from the multijet background using jet substructure information and association with a b-tagged jet. The measured spectra are corrected for detector effects to a particle-level fiducial phase space and a parton-level limited phase space, and are compared to several Monte Carlo simulations by means of calculated 2 values. The crosssection for t t production in the fiducial phase-space region is 292 AE 7stat AE 71syst fb, to be compared to the theoretical prediction of 384 AE 36 fb.
Enhancement and inhibition of snake venom phosphodiesterase activity by lysophospholipids (1998)

Lysophospholipids are liberated during venomous action. In this study we demonstrated that lysophosphatidyl choline (LPC) of various acyl chains enhances considerably the activity of snake venom phosphodiesterase (PDE). Lysophosphatidic acid (LPA) and its cyclic form (cLPA), on the other hand, were found to inhibit this enzyme in a non‐competitive (LPA) or competitive (cLPA) manner. Both of these activities may contribute to the progression and subsidence of the poisoning profile. PDE from cellular origin was not substantially affected by any of the above lysophospholipids.
Numerical Analysis of the Demagnetization Effect in a Superconducting Machine With Bulk HTS Material on the Rotor (2009)

When a bulk superconducting material is used as the magnets of an electric motor, the magnetized superconducting pucks are subjected to a varying magnetic field which has a detrimental effect on the trapped field. This may lead to a long term decay of the magnetization of the bulk superconductors. In this paper, we analyze numerically the demagnetization effect on bulk superconductors subjected to a magnetic field applied orthogonally to the initial direction of the trapped flux. The condition of a superconducting sample being exposed to a transverse field with varying magnitude is simulated and is very close to the operating environment in a synchronous machine. The decay of magnetization is calculated. The mechanism is explained in terms of the distortion of current distribution on the cross section of the sample. The long term effect of the application of a transverse field is predicted by the model.
ChemInform Abstract: Synthetic Strategies Towards the Total Synthesis of Phyllanthocin and Breynolide. Application of Stereochemically Linear and Convergent Strategies (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Studies of benzylisoquinolines. Comparison of the reactivity of the methylene group in 1‐benzyl and 4‐benzylisoquinolines (1989)

Abstract While examining the oxidation of 4‐benzylisoquinolines to the corresponding 4‐benzoylisoquinolines as well as the reactivity of these ketones towards hydroxylamine, reduction reagents and Grignard's reagents, there was found a definite difference in the behavior of the methylene group for these compounds as compared to that of papaverine (1‐benzylisoquinolines).
The Effect of Cyanobacterial Biomass Enrichment by Centrifugation and GF/C Filtration on Subsequent Microcystin Measurement (2015)

Microcystins are cyclic peptides produced by multiple cyanobacterial genera. After accumulation in the liver of animals they inhibit eukaryotic serine/threonine protein phosphatases, causing liver disease or death. Accurate detection/quantification of microcystins is essential to ensure safe water resources and to enable research on this toxin. Previous methodological comparisons have focused on detection and extraction techniques, but have not investigated the commonly used biomass enrichment steps. These enrichment steps could modulate toxin production as recent studies have demonstrated that high cyanobacterial cell densities cause increased microcystin levels. In this study, three microcystin-producing strains were processed using no cell enrichment steps (by direct freezing at three temperatures) and with biomass enrichment (by centrifugation or GF/C filtration). After extraction, microcystins were analyzed using liquid chromatography-tandem mass spectrometry. All processing methods tested, except GF/C filtration, resulted in comparable microcystin quotas for all strains. The low yields observed for the filtration samples were caused by adsorption of arginine-containing microcystins to the GF/C filters. Whilst biomass enrichment did not affect microcystin metabolism over the time-frame of normal sample processing, problems associated with GF/C filtration were identified. The most widely applicable processing method was direct freezing of samples as it could be utilized in both field and laboratory environments.
Photoluminescence Imaging of Semiconductors (2014)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
mTOR Signaling Regulates Metabolic Function in Oligodendrocyte Precursor Cells and Promotes Efficient Brain Remyelination in the Cuprizone Model (2021)

In demyelinating diseases, such as multiple sclerosis, primary loss of myelin and subsequent neuronal degeneration throughout the CNS impair patient functionality. While the importance of mechanistic target of rapamycin (mTOR) signaling during developmental myelination is known, no studies have yet directly examined the function of mTOR signaling specifically in the oligodendrocyte (OL) lineage during remyelination. Here, we conditionally deleted <i>Mtor</i> from adult oligodendrocyte precursor cells (OPCs) using <i>Ng2-Cre<sup>ERT</sup></i> in male adult mice to test its function in new OLs responsible for remyelination. During early remyelination after cuprizone-induced demyelination, mice lacking mTOR in adult OPCs had unchanged OL numbers but thinner myelin. Myelin thickness recovered by late-stage repair, suggesting a delay in myelin production when <i>Mtor</i> is deleted from adult OPCs. Surprisingly, loss of mTOR in OPCs had no effect on efficiency of remyelination after lysophosphatidylcholine lesions in either the spinal cord or corpus callosum, suggesting that mTOR signaling functions specifically in a pathway dysregulated by cuprizone to promote remyelination efficiency. We further determined that cuprizone and inhibition of mTOR cooperatively compromise metabolic function in primary rat OLs undergoing differentiation. Together, our results support the conclusion that mTOR signaling in OPCs is required to overcome the metabolic dysfunction in the cuprizone-demyelinated adult brain.<b>SIGNIFICANCE STATEMENT</b> Impaired remyelination by oligodendrocytes contributes to the progressive pathology in multiple sclerosis, so it is critical to identify mechanisms of improving remyelination. The goal of this study was to examine mechanistic target of rapamycin (mTOR) signaling in remyelination. Here, we provide evidence that mTOR signaling promotes efficient remyelination of the brain after cuprizone-mediated demyelination but has no effect on remyelination after lysophosphatidylcholine demyelination in the spinal cord or brain. We also present novel data revealing that mTOR inhibition and cuprizone treatment additively affect the metabolic profile of differentiating oligodendrocytes, supporting a mechanism for the observed remyelination delay. These data suggest that altered metabolic function may underlie failure of remyelination in multiple sclerosis lesions and that mTOR signaling may be of therapeutic potential for promoting remyelination.
Microfine coal firing results from a retrofit gas/oil-designed industrial boiler (1995)

The development of a High Efficiency Advanced Coal Combustor (HEACC) has been in progress since 1987 and the ABB Power Plant Laboratories. The initial work on this concept produced an advanced coal firing system that was capable of firing both water-based and dry pulverized coal in an industrial boiler environment. Economics may one day dictate that it makes sense to replace oil or natural gas with coal in boilers that were originally designed to burn these fuels. The objective of the current program is to demonstrate the technical and economic feasibility of retrofitting a gas/oil designed boiler to burn micronized coal. In support of this overall objective, the following specific areas were targeted: A coal handling/preparation system that can meet the technical requirements for retrofitting microfine coal on a boiler designed for burning oil or natural gas; Maintaining boiler thermal performance in accordance with specifications when burning oil or natural gas; Maintaining NOx emissions at or below 0.6 lb/MBtu; Achieving combustion efficiencies of 98% or higher; and Calculating economic payback periods as a function of key variables. The overall program has consisted of five major tasks: (1) A review of current state-of-the-art coal firing system components; (2) Design and experimental testing of a prototype HEACC burner; (3) Installation and testing of a HEACC system in a commercial retrofit application; (4) Economic evaluation of the HEACC concept for retrofit applications; and (5) Long term demonstration under commercial user demand conditions. This paper will summarize the latest key experimental results (Task 3) and the economic evaluation (Task 4) of the HEACC concept for retrofit applications. 28 figs., 6 tabs.
Beta-cell hyperresponsiveness: earliest event in development of diabetes in monkeys (1990)

Diabetes develops spontaneously in some, but not all, obese middle-aged monkeys. Longitudinal study of spontaneously obese rhesus monkeys has now shown the separation in time of the onset of various abnormalities associated with non-insulin-dependent diabetes mellitus (NIDDM). Glucose tolerance and acute and late insulin release were assessed at 6-mo to 1-yr intervals over a period of 7 yr in six young, lean, normal animals and 14 middle-aged obese, initially normoglycemic monkeys. Over 2-5 yr, while under study, five of the obese subjects developed overt diabetes [fasting plasma glucose greater than 140 mg/dl and decreased glucose disappearance rates (KG) less than 1.5]. Progressively increasing hyperinsulinemia leading to a 10-fold increase in basal plasma insulin levels (mean +/- SE = 443 +/- 69 microU/ml) and a fivefold increase in insulin response to glucose occurred independent of degree of obesity and before hyperglycemia. Later, basal and stimulated insulin levels declined before significant hyperglycemia. We conclude that in the monkey beta-cell function is clearly enhanced, not reduced, in the earliest stages of the progression to NIDDM but is reduced just before overt diabetes.
Absence of HIV DNA Sequences in Seronegative Polytransfused Thalassemic Patients (1990)

The risk of infection with human immunodeficiency virus (HIV) by transfusion is not totally eliminated, since contaminated blood given before seroconversion to HIV is not detected on the actual biological screening. We used the polymerase chain reaction (PCR) assay (with one primer pair in the gag region and two in the pol region) to detect HIV DNA sequences in 30 seronegative polytransfused thalassemic patients and in 60 seropositive individuals (used as positive controls). We did not observe PCR-positive HIV-antibody-negative results in seronegative polytransfused patients.
Line detection based on the basic masks and image rotation (2010)

In this paper we present a novel idea for the line detection based on the basic masks and rotation. Also, we implement the line detection algorithm that based on small eigenvalue analysis and proposed by Guru, Shekar and Nagabhushan [1]. Then, we provided a result of our testing of both algorithms and presented the finding and conclusion about the effective of the proposed algorithms.
Die CuCl‐katalysierte Reaktion von Trimethylsilyl(t‐butyl)chlorphosphan mit Dimethylzirconocen: Ein Beispiel der Tandem‐Katalyse (1996)

Abstract In situ aus t‐BuP(SiMe 3 ) 2 und Hexachlorethan erzeugtes t‐BuP(SiMe 3 )Cl reagiert mit Cp 2 ZrMe 2 in Gegenwart katalytischer Mengen an Kupfer(I)‐chlorid unter Bildung von t‐Bu(Me)PP(Cl)t‐Bu ( 1 ) (2 : 1‐Reaktion) oder t‐Bu(Me)PP(Me)t‐Bu ( 2 ) (1 : 1‐Reaktion) und Cp 2 ZrCl(Me). Zur Interpretation des Reaktionsverlaufs wurden die Umsetzung von Dimethylzirconocen mit CuCl sowie die Zersetzung von t‐BuP(SiMe 3 )Cl im Gegenwart von CuCl und Tetrachlorethen untersucht. Demnach reagiert CuCl mit t‐BuP(SiMe 3 )Cl in Gegenwart von C 2 Cl 4 zu t‐Bu(Cl)PP(Cl)t‐Bu ( 3 ); gleichzeitig bildet CuCl mit Cp 2 ZrMe 2 Methyl‐Kupfer, das mit 3 je nach Stöchiometrie zu 1 oder 2 reagiert.
Urgences vasculaires au cours de la drépanocytose chez le patient adulte (2004)

Auteur(s) : Evelyne Dupuy, Gerard Tobelem Service d’angiohematologie, Hopital Lariboisiere, 2, rue Ambroise-Pare, 75475 Paris cedex 10, France Correspondance et tires a part :E. Dupuy evelyne.dupuylrb.ap-hop-paris.fr La drepanocytose est une hemoglobinopathie constitutionnelle a transmission autosomale recessive. La drepanocytose est observee en Afrique equatoriale, dans l’est de l’Arabie Saoudite, dans certaines regions de l’Inde, certains villages du nord de la [...]
ADEPTUS: a discovery tool for disease prediction, enrichment and network analysis based on profiles from many diseases (2018)

Supplementary data are available at Bioinformatics online.
Children's interests and concerns when using the international children's digital library (2007)

This paper presents a case study of 12 children who used the International Children's Digital Library (ICDL) over four years and live in one of four countries: Germany, Honduras, New Zealand, and the United States. By conducting interviews, along with collecting drawings and book reviews, this study describes these children's interests in books, libraries, technology and the world around them. Findings from this study include: these young people increased the variety of books they read online; still valued their physical libraries as spaces for social interaction and reading; showed increased reading motivation; and showed interest in exploring different cultures.
Immune Mechanisms of Reversed Type Reaginic Hypersensitivity (1969)

Abstract F(ab')2 fragments of anti-γE obtained by pepsin digestion and reduced-alkylated anti-γE induced reversed type erythema-wheal reactions in normal individuals and released histamine from leukocytes, whereas Fab′ fragments of the antibody failed to do so. The requirement of two antibody-combining sites in anti-γE for induction of the reversed type allergic reactions suggested that bridging of two cell-bound γE molecules by anti-γE is the initial step of the reactions. On a molar basis, the original antibody and F(ab')2 fragments were comparable in their ability to induce the reversed allergic reactions, but the C′-fixing activity of the fragments was only 0.4% that of the undigested antibody. The results strongly suggested that C′ is not essential for induction of the reversed type reactions.
ChemInform Abstract: Enzymatic Resolution of 2‐Acyl‐3‐hydroxymethyl‐4‐butanolide and Preparation of Optically Active IM‐2, the Autoregulator from Streptomyces sp. FRI‐5. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.