gebhart/patrepeval huggingface dataset:
Physiological and pathophysiological aspects of cardiac prostaglandins (1983)

It has now been demonstrated that prostaglandins produce a wide variety of actions on cardiac tissue. These effects are quite complex and are dependent on such factors as type of prostaglandin, animal species, experimental format, as well as the amount of prostaglandin employed. The last factor is of particular concern since the administration of large amounts of prostaglandins may not truly reflect the actual actions of the endogenously synthesized prostaglandins which are likely to be at a very low concentration. In this review we have attempted to analyze the pharmacological properties of prostaglandins on cardiac tissue including coronary arteries and myocardium as well as the subcellular basis for their actions. The possible reasons for the diverse effects of prostaglandins under different experimental conditions have been pointed out. An effort has also been made to synthesize the existing information concerning the actions of prostaglandins on heart in terms of current concepts. A discussion is presented concerning the role of endogenously synthesized prostaglandins in physiological and pathological aspects of cardiac performance and the potential use of prostaglandins and prostaglandin synthesis inhibitors in the treatment of heart disease.
Controlling Small Positive-Displacement Motors when used with Coiled Tubing and Compressible Fluids (2000)

This paper presents a method of overcoming some of the problems associated with drilling with positive displacement motors (PDM’s) using compressible fluids. The specific problems addressed are:motor over-speeding resulting from sudden drops in motor load, often leading to stator
The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis (2010)

Intraflagellar transport (IFT) machinery mediates the bidirectional movement of cargos that are required for the assembly and maintenance of cilia. However, little is known about how IFT is regulated in vivo. In this study, we show that the small guanosine triphosphatase (GTPase) adenosine diphosphate ribosylation factor-like protein 13 (ARL-13) encoded by the Caenorhabditis elegans homologue of the human Joubert syndrome causal gene ARL13B, localizes exclusively to the doublet segment of the cilium. arl-13 mutants have shortened cilia with various ultrastructural deformities and a disrupted association between IFT subcomplexes A and B. Intriguingly, depletion of ARL-3, another ciliary small GTPase, partially suppresses ciliogenesis defects in arl-13 mutants by indirectly restoring binding between IFT subcomplexes A and B. Rescue of arl-13 mutants by ARL-3 depletion is mediated by an HDAC6 deacetylase-dependent pathway. Thus, we propose that two conserved small GTPases, ARL-13 and ARL-3, coordinate to regulate IFT and that perturbing this balance results in cilia deformation.
Processes in construction of failure management expert systems from device design information (1987)

The tasks and problem-solving methods used by an engineer in constructing a failure-management expert system from design information about the device to be diagnosed are analyzed. An expert test engineer developed a troubleshooting expert system based on device design information and experience with similar devices, rather than on specific expert knowledge gained from operating the device or troubleshooting its failures. The construction of the expert system was intensively observed and analyzed. The authors characterize the knowledge, tasks, methods, and design decisions involved in constructing this type of expert system, and make recommendations concerning tools for aiding and automating construction of such systems.
Gas Trapping During Foamed Flow in Porous Media (2011)

Two pore-scale constituents of foam mobility are effective yield stress and viscosity. These rheological quantities have been related directly to foam texture, flow rate, and morphology of the porous medium. It would be ideal to observe these relationships in natural rocks to capture more realistic foam behavior in the field. Since a technique for directly visualizing foam texture in natural porous media is not available, the interpretation of foam mobility on the basis of texture is impossible. Generally, all that is available is the measured pressure drop. Consider two typical foam processes commonly studied in the laboratory: liquid displacement by foam (LDF), and foam displacement by liquid (FDL). These processes represent many of the field applications of foam for gas/liquid mobility control. Experimental study of local foam mobility does not seem to have been reported in literature. The few existing investigations on in-situ foam-induced fluid partitioning have provided only partial insight into the conditions for foam generation. Apaydin and Kovscek [2000] verified their “bubble population balance’’ model by fitting the experimental onedimensional pressure drop and fluid saturation profiles during the transient foam displacement in sandpacks. The local liquid saturation profiles were determined using an Xray Computed Tomography (X-ray CT) technique. Wassmuth et al. [2001] conducted several foam-flood experiments, where distribution of local fluid saturations was visualized using a Magnetic Resonance Imaging (MRI) technique. The authors have not reported the corresponding pressure drop data, thus limiting the interpretation. Although most of the reported experimental studies [Zerhboub et al., 1994; Parlar et al., 1995; Siddiqui et al., 1997; Behenna, 1995; Thompson and Gdanski, 1993] on the FDL process have been focused on the acid diversion process, their outcomes are expected be relevant for water shut-off by foam. The insight gained into the FDL process is mainly due to Rossen and co-workers [1994, 2001], who conducted systematic studies using two-stage experiments of foam placement followed by liquid injection. Rossen et al. [1994, 2001] found that the pressure gradient declines in two steps. The pressure gradient first falls rapidly, but levels off to a value that remains relatively high. This is followed by a rather gradual decrease that leads to a quasi-steady state of liquid flow in the presence of significant trapped foam. The authors explained their results using a picture of foam flow in porous media in which the foam is separated in two parts. A (small) fraction of the foam is mobile following a mechanism of lamellae displacement. The remaining part exists in the form of trapped bubbles. When liquid is injected into the porous medium containing foam, the
Decreases in Ovarian Cytochrome P450c17α Activity and Serum Free Testosterone after Reduction of Insulin Secretion in Polycystic Ovary Syndrome (1996)

In obese women with the polycystic ovary syndrome, decreasing serum insulin concentrations with metformin reduces ovarian cytochrome P450c17 alpha activity and ameliorates hyperandrogenism.
A Novel Design of Temporary Bond Debond Adhesive Technology for Wafer-Level Assembly (2020)

Heterogeneous integration gained significant momentum in the semiconductor industry as it compliments lithographic scaling and offers alternative pathways to device improvement. Temporary bond debond technology (TBDB) with a glass carrier provides a manufacturing platform for this heterogeneous assembly on the wafer level. This paper describes the material development of a silicone-based temporary adhesive to enable robust bonding of the device wafer to glass carrier, as well as a thermoset polymer based laser release layer that enables stress-free glass debond upon receiving UV irradiation. We found that thermoset based temporary bond adhesive offers robust thermal stability, low outgassing, and excellent mechanical stability, making it suitable for wafer level assembly with a temporary glass carrier. An innovative, solvent-based cleaning solution was also identified to efficiently break down the crosslinked adhesive network, offering a robust wafer cleaning process, post laser debonding at room temperature. Some preliminary results of heterogeneous wafer level assembly using this novel temporary adhesive with laser debond will also be discussed.
Solution Conformation of Cis and Trans N‐Acetyl‐L‐Thiazolidine‐4‐Carboxylic Acid (1980)

Abstract From an extensive 1 H and 13 C NMR study, the conformation of cis‐ and trans‐N‐acetyl‐L‐thiazolidine‐4‐carboxylic acid in D 2 O is revealed to be close to an envelope with C β as the flap down (β − ) in the entire pD range. The pucker around N‐Cα remains pronounced (θ → 83°). The cis‐trans equilibrium is in favour of the trans isomer (70%) in acidic medium, but slightly in favour of the cis isomer (54%) in basic solution.
Anion-Migration-Induced Bipolar Resistance Switching in Electrochemically Deposited TiO[sub x] Films (2010)

films were electrochemically deposited on TiN and Pt electrodes with a subsequent annealing under or ambient. The resistive switching characteristics of such films were investigated. The electrodeposited films showed bipolar resistive switching and the operation voltages such as electroforming voltage, and reset/set voltages showed a dependence on the annealing ambient, displaying higher operation voltages for the annealing under than for the annealing under . The compositions of the different chemical states of species in films were observed to be modulated by the condition of electrochemical deposition and the subsequent annealing. The films annealed under the ambient showed a less concentration of nonlattice oxygen ions than under ambient. The reduction of nonlattice oxygen for annealing under was accompanied by the increase of in films and the increased reset/set voltages. It was concluded that the bipolar resistive switching of the electrochemically deposited film was strongly related to the nonlattice oxygen anions in the films.
ChemInform Abstract: ADDITION OF ALDEHYDES TO ACTIVATED DOUBLE BONDS, X. ADDITION OF ALIPHATIC, HETEROCYCLIC, AND AROMATIC ALDEHYDES TO α,β‐UNSATURATED KETONES, NITRILES, AND ESTERS (1976)

Abstract Sowohl aromatische, heterocyclische als auch aliphatische Aldehyde wie (I) addieren an die α,β‐ungesättigten Nitrile, Ester und Ketone (II) unter dem katalytischen Einfluß der Thiazoliumsalze (III) in Gegenwart von Basen.
Complete Genome Sequence of Streptacidiphilus sp. Strain 15-057A, Obtained from Bronchial Lavage Fluid (2018)

Streptacidiphilus sp. strain 15-057A was isolated from a bronchial lavage sample and represents the only member of the genus not isolated from acidic soils. A single circular chromosome of 7.01 Mb was obtained by combining Illumina and PacBio sequencing data. Bioinformatic analysis detected 63 putative secondary biosynthetic gene clusters and recognized 43 transposons.
The Assembly of AP-3 Adaptor Complex-containing Clathrin-coated Vesicles on Synthetic Liposomes (2000)

The heterotetrameric adaptor protein complex AP-3 has been shown to function in the sorting of proteins to the endosomal/lysosomal system. However, the mechanism of AP-3 recruitment onto membranes is poorly understood, and it is still uncertain whether AP-3 nucleates clathrin-coated vesicles. Using purified components, we show that AP-3 and clathrin are recruited onto protein-free liposomes and Golgi-enriched membranes by a process that requires ADP-ribosylation factor (ARF) and GTP but no other proteins or nucleotides. The efficiency of recruitment onto the two sources of membranes is comparable and independent of the composition of the liposomes. Clathrin binding occurred in a cooperative manner as a function of the membrane concentration of AP-3. Thin-section electron microscopy of liposomes and Golgi-enriched membranes that had been incubated with AP-3, clathrin, and ARF.GTP showed the presence of clathrin-coated buds and vesicles. These results establish that AP-3-containing clathrin-coated vesicles form in vitro and are consistent with AP-3-dependent protein transport being mediated by clathrin-coated vesicles.
Marfan syndrome, magnesium status and medical prevention of cardiovascular complications by hemodynamic treatments and antisense gene therapy. (2003)

The medical management of Marfan Syndrome (MFS) mainly relies on early prevention of the aortic complications. Hemodynamic treatments try to diminish the forcefulness of cardiac contractions and to reduce blood pressure: for example long term administration of propranolol may significantly reduce the rate of increase in aortic ratio (aortic diameter/expected aortic diameter). Retardation of aortic dilatation may be most often observed by early treatment started when the baseline end-diastolic aortic root diameter is < 40 mm. It seems better to use beta-blockers without intrinsic sympathomimetic activity. Successful acceptance of beta-blockers may be limited by side-effects, but the efficiency of alternative hypotensive agents (calcium channel inhibitors, ACE inhibitors) is not yet validated. Gene therapy might constitute an etiologic specific treatment of MFS. FBN1-RZ1 hammerhead antisense ribozyme is able to suppress expression of the mutant FBN1 allele. The use of ribozymes as systemic therapeutic agents will depend on efficient delivery to its target, but the various proposed vectors raise yet unsolved problems. A hydrogel angioplasty balloon might be a possible vector for delivering an antisense ribozyme in the aortic wall specifically. Ribozymes--as deoxyribonucleotides--may be taken up by tissue upon local application. Further research should study ex vivo local application of antisense ribozyme on human aortic wall, before assessing in vivo efficiency and tolerance of this aortic local vectorisation. It is always necessary to maintain a balanced magnesium intake in patients with MFS. Firstly to prevent the multiple noxious effects of magnesium deficiency on cardiovascular targets. Secondly to ensure the best efficiency and the least toxicity of the hemodynamic drugs used as long term prophylactic treatment for cardiovascular complications and of the etiologic antisense magnesium-dependent gene therapy, in the future.
Mechanics of Regenerative Vibration in Drilling: Analytical and Experimental Study of the Formation of Lobed Holes (2001)

Abstract Large-amplitude vibrations in drilling often occur near multiples of the rotation frequency, even when these frequencies are much lower than the system’s first natural frequency. These vibrations are responsible for out-of-round, “lobed” holes. A simplified model of the mechanics of this phenomenon is presented in this paper. The model includes cutting and “rubbing” forces on the drill, but inertia and damping of the tool are neglected at low speeds. This quasi-static model remains dynamic because of the regenerative nature of cutting; the force on each cutting element depends on both the tool’s current position and its position at the time of the previous tooth passage. Characteristic solutions, including unstable retrograde “whirling” modes, are found in terms of eigenvalues and eigenvectors of a discrete state-transition matrix. These unstable modes correspond closely to behavior observed in drilling tests.
Nuclear electric propulsion development and qualification facilities (1992)

This paper summarizes the findings of a Tri‐Agency panel; consisting of members from the National Aeronautics and Space Administration (NASA), U.S. Department of Energy (DOE), and U.S. Department of Defense (DOD); charged with reviewing the status and availability of facilities to test components and subsystems for megawatt‐class nuclear electric propulsion (NEP) systems. The facilities required to support development of NEP are available in NASA centers, DOE laboratories, and industry. However, several key facilities require significant and near‐term modification in order to perform the testing required to meet a 2014 launch date. For the higher powered Mars cargo and piloted missions, the priority established for facility preparation is: (1 thruster developmental testing facility, (2 thruster lifetime testing facility, (3 dynamic energy conversion development and demonstration facility, and (4 advanced reactor testing facility (if required to demonstrate an advanced multiwatt power system). Facilities to support development of the power conditioning and heat rejection subsystems are available in industry, federal laboratories, and universities. In addition to the development facilities, a new preflight qualification and acceptance testing facility will be required to support the deployment of NEP systems for precursor, cargo, or piloted Mars missions. Because the deployment strategy for NEP involves early demonstration missions, the demonstration of the SP‐100 power system is needed by the early 2000s.
THE SOLUBILITY OF TRIBUTYL PHOSPHATE IN AQUEOUS SOLUTIONS (1951)

without either dilution or addition of supporting eleclrolyte. Removal of dissolved oxygen and control of temperature were urnecessary. The precision of the method was better than plus or minus 5%, and the accuracy, which is dependent on calibration with a standard solution, was well within the precision value. The calibration curve is linear, for practical purposes, up to approximately 8 g/l UNH or 0.032 lb/gal uranium. (auth)
AIM-HI: A framework for request routing in large-scale IT global service delivery (2009)

In many network and IT (information technology) systems, users submit loosely defined (or “fuzzy”) requests to obtain answers, solutions, or resources. Fuzzy requests are often presented in problem tickets and processed by an IT service management system. In such a system, problems are typically reported using vague user-generated descriptions of the symptoms (e.g., “my e-mail is not working”). Making use of the reported symptoms, the incident management system is then responsible for identifying the component causing the problem. An accurate and quick diagnosis from the fuzzy symptoms becomes critical for an efficient and timely resolution of the problem. In this paper, we propose a system for automated incident management using historical information (AIM-HI), a framework for autonomous routing of requests in large-scale IT global service delivery. AIM-HI incorporates historical request resolution information and frequency, together with queue bouncing trends to extrapolate algorithms for streamlining and automating the dispatch of requests or work among support groups and IT specialists. The simplicity and scalability of AIM-HI should lead to deployment in actual real operational systems in the future.
New Myopathy With Mitochondrial Enzyme Hyperactivity (1967)

Applicationochemical techniques to the t study of skeletal muscle biopsies has led to the description of two new clinical pathological entities.<sup>1,2</sup>The value of these techniques in the study of neuromuscular disease has been detailed and emphasized by Engel.<sup>3</sup>A third myopathy with histochemically and ultrastructurally abnormal mitochondria has been described.<sup>4,5</sup>Recently we have obtained muscle biopsies from two patients whose clinical course was characterized by the onset during the first decade of life of progressive muscle fatigability, weakness, and slight atrophy, which was more prominent in the proximal muscles. Only focal fiber generation and occasional subsarcolemmous vacuoles were seen on routine histological sections, but application of histochemical techniques clearly defined abnormal mitochondria. These mitochondria were very active enzymatically and were present in 30% to 40% of the skeletal muscle fibers from both of these patients. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 9-year-old white girl was
Instrumentation Development for Site-Specific Prediction of Spectral Effects on Concentrated Photovoltaic System Performance (2014)

The description of a novel device to measure the spectral direct normal irradiance is presented. The solar spectral irradiance meter (SSIM) was designed at the University of Ottawa as a cost-effective alternative to a prohibitively expensive field spectroradiometer (FSR). The latter measures highly-varying and location-dependent solar spectrum, which is essential for accurate characterization of a concentrating photovoltaic system’s performance. The SSIM measures solar spectral irradiance in several narrow wavelength bands with a combination of photodiodes with integrated interference filters. This device performs spectral measurements at a fraction of the cost of a FSR, but additional post-processing is required to deduce the solar spectrum. The model was developed to take the SSIM’s inputs and reconstruct the solar spectrum in 280–4000 nm range. It resolves major atmospheric processes, such as air mass changes, Rayleigh scattering, aerosol extinction, ozone and water vapour absorptions. The SSIM was installed at the University of Ottawa’s CPV testing facility in September, 2013. The device gathered six months of data from October, 2013 to March, 2014. The mean difference between the SSIM and the Eppley pyrheliometer was within ±1.5% for cloudless periods in October, 2013. However, interference filter degradation and condensation negatively affected the performance of the SSIM. Future design changes will improve the longterm reliability of the next generation SSIMs.
Reye's and Reye-Like Syndromes, Drug-Related Diseases? (Causative Agents, Etiology, Pathogenesis, and Therapeutic Approaches) (1995)

In the literature the separation between RS and RLS is confusing and makes it difficult to plan an appropriate preventive action or to develop new therapeutic approaches. We suggest that the generalized damage and encephalopathy seen in both RS and RLS may be due to a wide variety of causative agents that contribute to a common derangement, principally involving mitochondrial oxidative pathway. Fasting status and infections increase the catabolism and the subsequent flux of metabolites from peripheral tissues to the liver (FA and amino acids); cytokines (TNF, IL-1, and IL-6), in particular, mediate this effect during infection and experimental endotoxemia. Some drugs and other toxic compounds induce functional and morphological liver mitochondrial derangement. Oxidative metabolism is impaired, with subsequent stimulation of alternative pathways of oxidation, following production of unusual toxic acyl CoAs and dicarboxylic acids. Toxic compounds accumulate in the liver, deranging its functions and causing energy depletion, and are also released in the circulation from which they reach other tissues, including the brain. Neurons and astrocytes in the brain may be affected differently: Neurons suffer from the lack of energy and the effect of toxic compounds arriving from the bloodstream, and astrocytes may be directly affected by the beta-oxidation derangement. Very important may be genetic predisposition, which, by making the patient more sensitive to a particular causative agent, may facilitate the onset of RS and RLS. The therapeutic approach is, presently, mainly symptomatic, directed as it is to counteracting each alteration shown, depending by the clinical gravity. Other pharmacological approaches are only studied experimentally, like carnitine supplementation and PGE2 administration, or theoretically envisaged, like monoclonal antibody therapy directed at LPS or at pro-inflammatory cytokines or treatment with interferon-alpha.