gebhart/patrepeval huggingface dataset:
Elimination of Antigen-Antibody Complexes from Sera of Rabbits, (1958)

Summary Various soluble antigen-antibody complexes have been injected intravenously into rabbits and their rate of elimination followed. When soluble BSA-anti-BSA complexes, prepared in the region of antigen excess, were injected intravenously into rabbits, a portion of these complexes was removed almost immediately, whereas another portion was eliminated at an exponential rate which had a half-life of approximately 2.7 days. A portion of similarly prepared BGG-anti-BGG complexes was eliminated from the circulation at an exponential rate which had a half-life of 1.8 days. In either system the rate of elimination of the complexes was more rapid than that of either antigen or antibody when injected alone. The amount of these complexes which continued to circulate following an injection depended to a large extent on their size which is determined by the amount of excess antigen used in their preparation. BSA-anti-BSA complexes prepared at equivalence with nonprecipitating antibody were almost completely eliminated from the sera in a few hours, whereas, BSA-(nonprecipitating) anti-BSA complexes prepared with a large amount of excess antigen were eliminated from the circulation at a rate which had a half-life of 2.3 days. There is some evidence that complement may play a role in the removal of soluble antigen-antibody complexes from the circulation.
ChemInform Abstract: VO<sub>2</sub>F(dmpz)<sub>2</sub>: A New Catalyst for Selective Oxidation of Organic Sulfides to Sulfoxides with H<sub>2</sub>O<sub>2</sub>. (2013)

Abstract A new penta‐coordinated vanadium complex is developed and characterized.
MORGAM (an international pooling of cardiovascular cohorts) (2004)

How did the study come about?
Blocking Ligand Occupancy of the αVβ3 Integrin Inhibits the Development of Nephropathy in Diabetic Pigs (2014)

Hyperglycemia stimulates secretion of αVβ3 ligands from vascular cells, including endothelial cells, resulting in activation of the αVβ3 integrin. This study determined whether blocking ligand occupancy of αVβ3 would inhibit the development of diabetic nephropathy. Ten diabetic pigs received an F(ab)2 fragment of an antibody directed against the extracellular domain of the β3-subunit, and 10 received a control IgG F(ab)2 for 18 weeks. Nondiabetic pigs excreted 115 ± 50 μg of protein/mg creatinine compared with control F(ab)2-treated diabetic animals (218 ± 57 μg/mg), whereas diabetic animals treated with the anti-β3 F(ab)2 excreted 119 ± 55 μg/mg (P < .05). Mesangial volume/glomerular volume increased to 21 ± 2.4% in control-treated diabetic animals compared with 14 ± 2.8% (P < .01) in animals treated with active antibody. Diabetic animals treated with control F(ab)2 had significantly less glomerular podocin staining compared with nondiabetic animals, and this decrease was attenuated by treatment with anti-β3 F(ab)2. Glomerular basement membrane thickness was increased in the control, F(ab)2-treated diabetic animals (212 ± 14 nm) compared with nondiabetic animals (170 ± 8.8 nm), but it was unchanged (159.9 ± 16.4 nm) in animals receiving anti-β3 F(ab)2. Podocyte foot process width was greater in control, F(ab)2-treated, animals (502 ± 34 nm) compared with animals treated with the anti-β3 F(ab)2 (357 ± 47 nm, P < .05). Renal β3 tyrosine phosphorylation decreased from 13 934 ± 6437 to 6730 ± 1524 (P < .01) scanning units in the anti-β3-treated group. We conclude that administration of an antibody that inhibits activation of the β3-subunit of αVβ3 that is induced by hyperglycemia attenuates proteinuria and early histologic changes of diabetic nephropathy, suggesting that it may have utility in preventing the progression of this disease complication.
Delayed Vertebro-Basilar Insufficiency Following Cervical Spine Injury (1985)

From the Department of Neurosurgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania
<title>Wireless surface acoustic wave and MEMS-based microsensors</title> (2001)

The integration of SAW (Surface Acoustic Wave), MEMS and required microelectronics and conformal antennas to realize programmable microsensors suitable for many engineering and biomedical applications will be presented in this talk. This unique combination of technologies results in novel conformal sensors that can be remotely sensed by a wireless communication system with the advantage of no power requirements at the sensor site (passive sensor). The required features in many of these applications are high precision, wide dynamic range and wide frequency range. MEMS-SAW based devices presented possess typical advantages of MEMS sensors including the additional benefits of robustness, excellent sensitivity, surface conformability and durability. After a brief overview of SAW sensors and MEMS, the paper is focused on the design and fabrication of MEMS devices for a few engineering applications such as accelerometer and gyroscopes for automobile, inertial navigation sensors and tire pressure sensor.
Diagnostic Imaging in Fracture of Lumbar Vertebral Ring Apophyses (1992)

The findings at plain radiography, myelography, CT, and MR imaging in 3 cases of fracture of the lumbar vertebral ring apophysis are presented. Familiarity with this entity is important in evaluating low back pain in children and young adults. Conventional radiographs and/or MR imaging may suggest ring apophysis fracture; CT will confirm and classify the diagnosis.
Optical modulators based on a dual-frequency nematic liquid crystal (2008)

This paper experimentally investigates the dynamic characteristics of electrically controlled modulators based on liquid crystals (LCs) in the visible and near-IR regions and the effect of the electric-field parameters on them, along with the variation of the conditions of the interphase interaction of the LCs with the orienting surface. It is shown that it is effective to use a dual-frequency liquid crystal for phase and amplitude modulation of radiation with wavelength 1.55μm. In an LC modulator operating on the S effect, a 2π phase lag is obtained in a time of 2ms. The switching times can be reduced to the microsecond range when the twist effect is used and the LC layer is about 7μm thick by increasing the voltage from 30to50V.
Low energy differential and integral electron-impact cross sections for the 2s<sup>2</sup>2p<sup>4</sup><sup>3</sup>P   2p<sup>3</sup>3s<sup>3</sup>S<sup>o</sup>excitation in atomic oxygen (2003)

Differential and integral cross sections (ICSs) for excitation in atomic oxygen have been measured at electron-impact energies of 15, 17.5, 20, 22.5 and 27.5 eV. Differential measurements were conducted with a conventional electron energy-loss spectrometer and a microwave discharge source of atomic oxygen. Relative differential cross sections (DCSs) were determined between 15 and 30 eV impact energy. With the help of theoretical predictions of the shape of the DCS at large angles, measured results were extrapolated to 180° scattering angle and relative ICSs were deduced. The relative excitation function was normalized to the 30 eV impact energy ICS given by Kanik et al (2001 J. Phys. B: At. Mol. Opt. Phys. 34 2647). Normalization of the ICS values allowed the measured DCSs to be put on the absolute scale. Theoretical calculations of the DCSs were carried out using the R-matrix with the pseudostates approach. A total of 22 spectroscopic bound and autoionizing states, together with 19 pseudostates, were included in the close-coupling expansion. The pseudostates were chosen to simulate continuum target states. Theoretical results, along with other available experimental data, have been compared with the current experimental results.
A Spectrophotometric Method For the Quantitative Estimation of Technical Chlordane (1950)

Journal Article A Spectrophotometric Method For the Quantitative Estimation of Technical Chlordane Get access Bernard Davidow Bernard Davidow Division of Pharmacology, Food and Drug Administration, Federal Security Agency, Washington, D. C Search for other works by this author on: Oxford Academic Google Scholar Journal of Association of Official Agricultural Chemists, Volume 33, Issue 3, 1 August 1950, Pages 886–894, https://doi.org/10.1093/jaoac/33.3.886 Published: 09 February 2020
Evaluation of a New Care System Provided to Diabetic Patients in the Outpatient Clinic. (2000)

Introduction of the standardized "Diabetes Follow-up Clinic" may be one of the choices for increasing the quality of outpatient care and for the prevention of chronic diabetic complications.
Editorial (2001)

Diabetes Research enters its second year of publication, we would like to take this oppor- tunity to thank all those who helped the jour- nal get off to a successful start.In the first year we dedi- cated our attention to the publication of quality peer- reviewed research articles.
PITFALLS IN THE MANAGEMENT OF PENETRATING INJURIES OF THE FOREARM (1971)

SYMONDS, FRANCIS C. M.D.; GARNES, ARTHUR L. M.D.; PORTER, VINCENT M.D.; CRIKELAIR, GEORGE F. M.D. Author Information
Enhanced mutagenesis of UV-irradiated simian virus 40 occurs in mitomycin C-treated host cells only at a low multiplicity of infection. (1986)

Treatment of monkey kidney cells with mitomycin C (MMC) 24 h prior to infection with UV-irradiated simian virus 40 (SV40) enhanced both virus survival and virus mutagenesis. The use of SV40 as a biological probe has been taken as an easy method to analyse SOS response of mammalian cells to the stress caused by DNA damage or inhibition of DNA replication. The mutation assay we used was based on the reversion from a temperature-sensitive phenotype (tsA58 mutant) to a wild-type phenotype. The optimal conditions for producing enhanced survival and mutagenesis in the virus progeny were determined with regard to the multiplicity of infection (MOI). Results showed that the level of enhanced mutagenesis observed for UV-irradiated virus grown in MMC-treated cells was an inverse function of the MOI, while enhanced survival was observed at nearly the same level regardless of the MOI. For the unirradiated virus, almost no increase in the mutation of virus progeny issued from MMC-treated cells was observed, while a small amount of enhanced virus survival was obtained. These results show that enhanced virus mutagenesis and enhanced virus survival can be dissociated under some experimental conditions. Enhanced virus mutagenesis, analogous to the error-prone replication of phages in SOS-induced bacteria, was observed, at least for SV40, only when DNA of both virus and host cells was damaged and when infection occurred with a small number of viral particles. We therefore hypothesize that an error-prone replication mode of UV-damaged templates is observed in induced monkey kidney cells.
Variability in the Properties of Silicone Gel Breast Implants (2001)

Several generations of silicone gel breast implants have been produced by implant manufacturers. The primary material usually viewed as the base material in the manufacture of implants is polydimethylsiloxane. Polymeric reactions are notorious for their variability and nonuniformity. The elastomer used in different types of implants can have vastly different properties. Furthermore, the material properties associated with a particular type of implant can vary considerably from one lot to the next. Considering the various designs, styles, and manufacturing techniques associated with silicone gel implants, knowledge of the original properties of the implants before implantation is important in determining the effects of aging in vivo. This study was conducted to investigate differences in key mechanical and chemical properties of silicone gel breast implant materials. The two types of implants chosen for analysis were Silastic I and Silastic II control implants. Material property data were determined for both types of controls and significant differences were found in their values. Lot-to-lot variability was also investigated and found to be significant.
IMPROVED OXIDATION RESISTANCE OF MOLYBDENUM BY ALLOYING WITH RARE EARTH AND OTHER SELECTED METALS (1963)

Abstract : The diffusion rates of hafnium and of oxygen in the alloys during the process of internal oxidation obey the Arrhenius law, as evidenced by straight line plots of log D vs 1/T. This is substantiated by data at three temperatures, 1100, 1200 and 1300 deg C.
Asymptomatic Ventricular Preexcitation (2009)

These results indicate that prognosis of adults who present with asymptomatic ventricular preexcitation is good, and the risk of a significant event is small. Short anterograde effective refractory period of the accessory pathway and inducibility at baseline are independent predictors of potentially life-threatening arrhythmic events, and the risk decreases with increasing age.
Effect of Ischemia on Implantable Defibrillator Intracardiac Shock Electrograms (2007)

Ischemia affects ICD shock EGMs in a manner that appears to vary depending on the culprit vessel. Our data demonstrate the feasibility of ischemia detection from ICD shock EGMs.
Impact of Polymers on the Precipitation Behavior of Highly Supersaturated Aqueous Danazol Solutions (2014)

The phase behavior of supersaturated solutions of a relatively hydrophobic drug, danazol, was studied in the absence and presence of polymeric additives. To differentiate between phase separation to a noncrystalline phase and phase separation to a crystalline phase, an environmentally sensitive fluorescent probe was employed. Induction times for crystallization in the presence and absence of polymeric additives were studied using a combination of ultraviolet and fluorescence spectroscopy. It was found that, when danazol was added to aqueous media at concentrations above the amorphous solubility, liquid-liquid phase separation was briefly observed prior to crystallization, resulting in a short-lived, drug-rich noncrystalline danazol phase with an initial size of around 500 nm. The addition of polymers was found to greatly extend the lifetime of the supersaturated two phase system, delaying the onset of crystallization from a few minutes to a few hours. Below a certain threshold danazol concentration, found to represent the amorphous solubility, only crystallization was observed. Thus, although the addition of polymers was unable to prevent danazol from precipitating once a threshold concentration was exceeded, they did inhibit crystallization, leading to a solution with prolonged supersaturation. This observation highlights the need to determine the structure of the precipitating phase, since it is linked to the resultant solution concentration time profile.
IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation (2011)

AKT activation requires phosphorylation of the activation loop (T308) by 3-phosphoinositide-dependent protein kinase 1 (PDK1) and the hydrophobic motif (S473) by the mammalian target of rapamycin complex 2 (mTORC2). We recently observed that phosphorylation of the AKT hydrophobic motif was dramatically elevated, rather than decreased, in mTOR knockout heart tissues, indicating the existence of other kinase(s) contributing to AKT phosphorylation. Here we show that the atypical IκB kinase ε and TANK-binding kinase 1 (IKKε/TBK1) phosphorylate AKT on both the hydrophobic motif and the activation loop in a manner dependent on PI3K signaling. This dual phosphorylation results in a robust AKT activation in vitro. Consistently, we found that growth factors can induce AKT (S473) phosphorylation in Rictor(-/-) cells, and this effect is insensitive to mTOR inhibitor Torin1. In IKKε/TBK1 double-knockout cells, AKT activation by growth factors is compromised. We also observed that TBK1 expression is elevated in the mTOR knockout heart tissues, and that TBK1 is required for Ras-induced mouse embryonic fibroblast transformation. Our observations suggest a physiological function of IKKε/TBK1 in AKT regulation and a possible mechanism of IKKε/TBK1 in oncogenesis by activating AKT.
Glucosamine oligomers : 3. Study of the elution process on polyacrylamide gels, application to other polyamine oligomer series (1991)

International audience
A Study on the Depaminergic Control of T.S.H. Secretion (1978)

To elucidate the depaminergic control of T.S.H. secretion, we analized the pattern of T.S.H. secretion in seven normal controls and nine primary hypothyroid subjects, before and after single or combined administration of specific dopaminergic,receptor blocker, metoclopramide, and specific depaminergic receptor stimulant, bromergocryptine(CB-154). The results obtained were as follows: 1) There was a significant rise in T.S.H. levels after intra venous injection of metocloramide (10mg) in hypothyroid subjects. But there was no significant rise in T.S.H. levels in normal controls. The T.S.H. response to metoclopramide varied considerably, being large in mild cases and small in severely hypothyroid subjects. 2) There was a significant fall in T.S.H. levels after oral administration of bromergocryptine (2mg) in hypothyroid subjects, but there was no significant fall in T.S.H. levels in normal controls. 3) There was no significant fluctuation in T.S.H. levels after combined administration of both metoclopramide and bromergocrytine. 4) There was no significant fluctuation in T.S.H. levels after intravenous injection of normal saline(2ml) in both hypothyroid and normal subjects. 5) There was no significant change in serum after administration of metoclopramide and and bromergocryptine respectively and serially. These data support the fact that there is a dopaminergic control in the secretion of T.S.H. in the human.
A pilot study to determine the effect of trunk and hip focused neuromuscular training on hip and knee isokinetic strength (2008)

Ten weeks of TNMT increased standing hip abduction strength in female athletes. Increased hip abduction strength and recruitment may improve the ability of female athletes to increase control of lower limb alignment and decrease knee loads resulting from increased trunk displacement during sports activities.
Hydroxyquinone O-Methylation in Mitomycin Biosynthesis (2007)

Mitomycins are bioreductively activated DNA-alkylating agents. One member of this family, mitomycin C, is in clinical use as part of combination therapy for certain solid tumors. The cytotoxicity displayed by mitomycins is dependent on their electrochemical potential which, in turn, is governed in part by the substituents of the quinone moiety. In this paper we describe studies on the biogenesis of the quinone methoxy group present in mitomycins A and B. An engineered Streptomyces lavendulae strain in which the mmcR methyltransferase gene had been deleted failed to produce the three mitomycins (A, B, and C) that are typically isolated from the wild type organism. Analysis of the culture extracts from the mmcR-deletion mutant strain revealed that two new metabolites, 7-demethylmitomycin A and 7-demethylmitomycin B, had accumulated instead. Production of mitomycins A and C or mitomycin B was selectively restored upon supplementing the culture medium of a S. lavendulae strain unable to produce the key precursor 3-amino-5-hydroxybenzoate with either 7-demethylmitomycin A or 7-demethylmitomycin B, respectively. MmcR methyltransferase obtained by cloning and overexpression of the corresponding mmcR gene was shown to catalyze the 7-O-methylation of both C9beta- and C9alpha-configured 7-hydroxymitomycins in vitro. This study provides direct evidence for the catalytic role of MmcR in formation of the 7-OMe group that is characteristic of mitomycins A and B and demonstrates the prerequisite of 7-O-methylation for the production of the clinical agent mitomycin C.
Determination of Electron Affinity Differences by Surface Ionization (1966)

Electron affinity differences determined by surface ionization on hot tungsten through use of polyatomic halogen molecular beam
Protamine Reversal of Heparin Affects Platelet Aggregation and Activated Clotting Time After Cardiopulmonary Bypass (1998)

Bleeding after cardiopulmonary bypass (CPB) is related to multiple factors.Excess protamine weakens clot structure and decreases platelet function; therefore, an increased activated clotting time (ACT) after protamine reversal of heparin may be misinterpreted as residual heparin anticoagulation. We evaluated the effects of protamine, recombinant platelet factor 4 (rPF4), and hexadimethrine on ACT in blood obtained after CPB. In addition, we examined the effect of protamine on in vitro platelet aggregation. Incremental doses of protamine, rPF4, and hexadimethrine were added to heparinized blood from CPB, and ACTs were performed. Incremental concentrations of protamine were added to heparinized platelet-rich plasma, and aggregometry was induced by adenosine diphosphate (ADP) and collagen. The mean heparin concentration at the end of CPB was 3.3 U/mL. Protamine to heparin ratios >1.3:1 produced a significant prolongation of the ACT that was not seen with rPF4 and was observed only with 5:1 hexadimethrine to heparin ratios. ADP-induced platelet aggregation was reduced with protamine administration >or=to1.3:1. Excessive protamine reversal of heparin prolongs ACT and alters ADP-induced platelet aggregation in a dose-dependent manner in vitro. Additional protamine administered to treat a prolonged ACT may further increase clotting time, reduce platelet aggregation, and potentially contribute to excess bleeding after CPB. Implications: We found that excess protamine prolonged the activated clotting time and altered platelet function after cardiopulmonary bypass, whereas heparin antagonists, such as recombinant platelet factor 4 and hexadimethrine, exhibited a wider therapeutic range without adversely affecting the activated clotting time. Approaches to avoid excess protamine or use of alternative heparin antagonists after cardiopulmonary bypass may be beneficial. (Anesth Analg 1998;87:781-5)
Accelerating continuous range queries processing in location based networks on GPUs (2014)

Welcome to the WIT Press eLibrary - the home of the Transactions of the Wessex Institute collection, providing on-line access to papers presented at the Institute's prestigious international conferences and from its State-of-the-Art in Science & Engineering publications.
Stimulatory Role of Substance P on Gonadotropin Release in Ovariectomized Rats (1990)

Substance P (SP) has been shown to be present in the hypothalamus and anterior pituitary. To evaluate a possible physiological role of endogenous SP in the control of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release, specific antiserum against SP (anti-SP) was injected intraventricularly (3 microliters into the third ventricle) or intravenously (50 or 200 microliters) into conscious, ovariectomized (OVX) rats. Third ventricular injection of the antiserum induced a significant decrease in both plasma LH and FSH levels when compared to values in control animals injected with normal rabbit serum (p less than 0.01 and p less than 0.025, respectively). The effect was observed within 10 mi and levels remained suppressed for 60 min. In contrast, intravenous injection of large doses of anti-SP had no effect on the release of both hormones. In order to confirm the stimulatory effect of SP itself, synthetic SP was injected intravenously and intraventricularly into estrogen-primed (E-primed), OVX rats. Synthetic SP dramatically stimulated LH release, but not FSH release when injected either intravenously or intraventricularly at doses of 10 and 50 micrograms (p less than 0.001, p less than 0.005 vs. control, respectively). To investigate any direct action of SP on gonadotropin release from the anterior pituitary gland, synthetic SP was incubated with dispersed anterior pituitary cells harvested from E-primed OVX rats. SP did not affect the release of gonadotropins in vitro. These results indicate that endogenous hypothalamic SP exerts a tonic stimulatory hypothalamic control of basal gonadotropin release in OVX rats.