gebhart/patrepeval huggingface dataset:
Kinetics of ligand substitution of tris(2,2'-bipyridine)chromium(III) in aqueous solutions (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of ligand substitution of tris(2,2'-bipyridine)chromium(III) in aqueous solutionsM. Maestri, F. Bolletta, N. Serpone, L. Moggi, and V. BalzaniCite this: Inorg. Chem. 1976, 15, 9, 2048–2051Publication Date (Print):September 1, 1976Publication History Published online1 May 2002Published inissue 1 September 1976https://pubs.acs.org/doi/10.1021/ic50163a007https://doi.org/10.1021/ic50163a007research-articleACS PublicationsRequest reuse permissionsArticle Views254Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation* (2015)

Prostate cancer is the most common cancer among men in the U.S. and worldwide, and androgen-deprivation therapy remains the principal treatment for patients. Although a majority of patients initially respond to androgen-deprivation therapy, most will eventually develop castration resistance. An increased understanding of the mechanisms that underline the pathogenesis of castration resistance is therefore needed to develop novel therapeutics. LNCaP and PC3 prostate cancer cell lines are models for androgen-dependence and androgen-independence, respectively. Herein, we report the comparative analysis of these two prostate cancer cell lines using integrated global proteomics and glycoproteomics. Global proteome profiling of the cell lines using isobaric tags for relative and absolute quantitation (iTRAQ) labeling and two- dimensional (2D) liquid chromatography-tandem MS (LC-MS/MS) led to the quantification of 8063 proteins. To analyze the glycoproteins, glycosite-containing peptides were isolated from the same iTRAQ-labeled peptides from the cell lines using solid phase extraction followed by LC-MS/MS analysis. Among the 1810 unique N-linked glycosite-containing peptides from 653 identified N-glycoproteins, 176 glycoproteins were observed to be different between the two cell lines. A majority of the altered glycoproteins were also observed with changes in their global protein expression levels. However, alterations in 21 differentially expressed glycoproteins showed no change at the protein abundance level, indicating that the glycosylation site occupancy was different between the two cell lines. To determine the glycosylation heterogeneity at specific glycosylation sites, we further identified and quantified 1145 N-linked glycopeptides with attached glycans in the same iTRAQ-labeled samples. These intact glycopeptides contained 67 glycan compositions and showed increased fucosylation in PC3 cells in several of the examined glycosylation sites. The increase in fucosylation could be caused by the detected changes in enzymes belonging to the glycan biosynthesis pathways of protein fucosylation observed in our proteomic analysis. The altered protein fucosylation forms have great potential in aiding our understanding of castration resistance and may lead to the development of novel therapeutic approaches and specific detection strategies for prostate cancer.
Hot filament infrared radiators and pyroelectric single-element detectors for analytical application (2000)

The infrared source and detector are essential components of infrared analyzers. They basically determine the system's resolution, its size, energy demand and price. This paper describes the schematic set-up and the basic characteristics of radiators and pyroelectric single-element detectors that have been developed for the efficient application in the wavelength range 2-15 micrometers . On the one hand, the infrared sources are housed in a transistor package (TO-39, TO-8), electrical input power less than 10 watts and, on the other hand, in a glass bulb with a fitted infrared window, electrical input power 15-30 watts. They are based on tungsten filaments. It is shown that the radiators are optimized for high radiation power and a direct modulation capability with a sufficient modulation depth (50%) of up to 30 Hz. Calcium fluoride and zinc selenide were chosen as window materials. In particular for analytical applications, pyroelectric infrared sensors with small responsive elements have been developed, which are characterized by high responsivity, high specific detectivity and an optimized spectral responsivity. As a result, responsivity values S<SUB>v</SUB> of (500 K; 10 Hz; 25 degree(s)C; (tau) <SUB>F</SUB> equals 1)>=6,000 VW<SUP>-1</SUP> and a specific detectivity D*(500 K; 10 Hz; 1Hz; 25 degree(s)C)>=4 x 10<SUP>8</SUP> cm Hz<SUP>1/2</SUP>W<SUP>-1</SUP> have been obtained for LiTaO<SUB>3</SUB> sensors with a responsive area of 0.5 mm.
Glyphosate translocation in herbicide tolerant plants (2012)

The objective of this study was to evaluate glyphosate translocation in glyphosate-tolerant weed species (I. nil, T. procumbens and S. latifolia) compared to glyphosate-susceptible species (B. pilosa). The evaluations of 14C-glyphosate absorption and translocation were performed at 6, 12, 36 and 72 hours after treatment (HAT) in I. nil and B. pilosa, and only at 72 HAT in the species T. procumbens and S. latifolia. The plants were collected and fractionated into application leaf, other leaves, stems, and roots. In S. latifolia, approximately 88% of the glyphosate remained in the application leaf and a small amount was translocated to roots at 72 HAT. However, 75% of the herbicide applied on T. procumbens remained in the leaf that had received the treatment, with greater glyphosate translocation to the floral bud. It was concluded that the smaller amount of glyphosate observed in S. latifolia and T. procumbens may partly account for their higher tolerance to glyphosate. However, I. nil tolerance to glyphosate may be associated with other factors such as metabolization, root exudation or compartmentalization, because a large amount of the herbicide reached the roots of this species.
Cutaneous autoimmune effects in the setting of therapeutic immune checkpoint inhibition for metastatic melanoma (2016)

Therapeutic immune checkpoint blockade for metastatic melanoma has been associated with vitiligo, pruritus and morbilliform eruptions. Reports of other autoimmune skin disease in this setting are rare. We sought to expand the spectrum of cutaneous immune-mediated effects related to immune checkpoint inhibitor therapy. In this report, we describe two unusual cutaneous reactions related to checkpoint inhibitor therapy, namely bullous pemphigoid (BP) and dermatitis herpetiformis. The development of BP and dermatitis herpetiformis in the context of checkpoint inhibitor therapy is consistent with previous investigations supporting the importance of effector and regulatory T cells in the pathogenesis of these diseases.
Monensin toxicosis in the domestic bovine calf: a large animal model of cardiac dysfunction. (2005)

A large animal with diminished cardiac function would be desirable for chronic testing of pathophysiologic responses to many human-sized devices and other therapies, especially if this model did not require prior surgical interventions or extensive technical skill and expense. Overdoses of monensin, widely used in the cattle industry as a growth promotant, are cardiotoxic, suggesting its possible use in creating cardiomyopathy. We gave a single oral dose of monensin (20 to 40 mg/kg) to 13 calves (55 to 90 kg) to produce diminished cardiac function. Hemodynamics and cardiac geometry were monitored for as long as 21 days postinduction. Within 3 days, there were signs of decreased cardiac function, as evidenced by a 10- to 20-mm Hg decrease in peak systolic blood pressure (P < 0.01 versus baseline) and a 2- to 9-mm Hg increase in central venous pressure (P < 0.01 versus baseline). There was a trend towards an increase in left ventricular end-systolic lumen diameter. Compared with those of similar-sized normal animals, stroke volume was 42% lower (P < 0.05), left atrial pressure was 67% higher (P < 0.01), and end-diastolic left ventricular pressure was 143% higher (P < 0.05). Histopathologic analysis showed extensive cardiomyocyte death. These results suggest that monensin could provide a simple, noninvasive, inexpensive, and likely irreversible means of producing clinically relevant diminished cardiac function in a human-sized animal model.
FACILIDAD A SERVIDORES DEL SENADO PARA ESTUDIOS DE POSGRADO (2014)

LA UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO Y EL SENADO DE LA REPUBLICA FIRMARON UN CONVENIO DE COLABORACION ACADEMICA CON EL OBJETIVO DE CONJUGAR SUS ESFUERZOS PARA QUE LOS SERVIDORES PUBLICOS DE ESE ORGANO LEGISLATIVO QUE TENGAN INTERES EN HACERLO Y ACREDITEN LOS REQUISITOS, REALICEN LOS ESTUDIOS CORRESPONDIENTES AL PROGRAMA DE POSGRADO EN DERECHO.
Reconstruction of a first-order phase transition from computer simulations of individual phases and subphases (1996)

We present a method for investigating first-order phase transitions using Monte Carlo simulations. It relies on the multiple-histogram method and uses solely histograms of individual phases. In addition, we extend the method to include histograms of subphases. The free energy difference between phases, which is necessary for attributing the correct statistical weights to the histograms, is determined by a detour in control parameter space via auxiliary systems with short relaxation times. We apply this method to a recently introduced model for structure formation in polypeptides for which other methods fail.
One Surprise after Another (2005)

A previously healthy, 22-year-old man presented to an emergency department reporting three days of intermittent abdominal pain. Although the pain was initially mild and crampy and was relieved with bismuth subsalicylate, on the day he went to the hospital the patient awoke with severe, midepigastric pain and had two episodes of diarrhea. During the preceding week, he had had a productive cough and had noticed a slight decrease in exercise tolerance.
Stereological Analysis of Cerebral Atrophy in Human Immunodeficiency Virus-associated Dementia (1996)

Brain atrophy is a common finding in patients with AIDS, but the relationship of atrophy to HIV-associated dementia is unclear. We used unbiased, stereological methods on postmortem brain specimens to estimate volumes of different brain regions in patients prospectively diagnosed with and without HIV-associated dementia. Thirty HIV-seropositive (9 without AIDS/without dementia, 6 with AIDS/without dementia, 15 with AIDS/with dementia) and 7 HIV-seronegative controls were studied using the technique of point counting and Cavalieri's principle of volume estimation. There was a significant reduction in the mean neocortical volume (15%, p = 0.032) in the group with AIDS when compared to the seronegative controls, and this difference was accentuated when comparing only the group with HIV-associated dementia to the seronegatives (neocortex: 18%, p = 0.020). There were no significant differences between the AIDS groups with and without HIV-associated dementia, although there was a trend for smaller volumes in the most severely demented patients. There were no differences in white matter volumes between groups. In conclusion, patients dying with AIDS and particularly those with HIV-associated dementia, show significant neocortical atrophy when compared to seronegative controls. The lack of a significant difference in cerebral atrophy between HIV-seropositive patients with and without dementia suggests that atrophy may be a more generalized phenomenon of AIDS as opposed to a specific marker for HIV-associated dementia.
A Signal Processing for Realization of Ultrasonic Observation System of Sea Flow over a Long Distance (1982)

The velocity of a current going in and out through a strait can be measured by the differences in underwater sound propagation times with and against the current. A test measuring current velocity was carried out using a trial system which adopted a two-period M-sequence method to reduce the interference of ambient pulsive noises. To realize an easy ultrasonic observation system of sea flow over long distances, we devised a new signal processing system. The results gained by the customary method and by this new technique were compared.
116. Pharmacodynamic compounds. Part III. Antitussives derived from 1-alkylpyrrolidinyl and 1-alkylpiperidyl alcohols (1964)

F. P. Doyle, M. D. Mehta, G. S. Sach, R. Ward and P. S. Sherman, J. Chem. Soc., 1964, 578 DOI: 10.1039/JR9640000578
The energetic cost of adaptive feet in walking (2011)

While humanoid feet are made of rigid plates, human feet have evolved into highly articulated and flexible elements. This adaptiveness provides key advantages. It absorbs impacts and secures grip when interacting with the environment. However, the human foot design potentially increases the energetic cost, because it features actuators and provides less power transfer than a rigid plate does. Here we use neuromuscular models with different foot designs and show that human feet incur about 20% more energetic cost than rigid ones for walking speeds up to 1.2ms <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , which is close to the preferred walking speed. Above this speed, human feet do not show an energetic disadvantage. In addition we propose a foot design for prosthetic or humanoid feet which preserves key features of adaptive feet but does not require actuation, and show that it reduces the energetic cost by 15% or more independent of the walking speed. We conclude that human evolution may have traded the advantages of adaptive feet for energy efficiency, and that robotic systems could gain the former without compromising on the latter.
Implementation of RAID (2003)

RAID is a robust and adaptable distributed system for transaction processing. It is a message-passing system, with server processes on each site. A high-level, layered communications package provides a clean, location independent interface between servers. RAID processes concurrent updates and retrievals on multiple sites. The servers manage concurrent processing, consistent replicated copies during site failures or network partitionings, and atomic distributed commitment. The latest version of the communications package is able to deliver messages in a high-performance configuration in which several servers are linked into a single process. RAID provides the infrastructure to investigate experimentally various methods for supporting reliable distributed-transaction processing. Experiments on handling site failure with partial replication, checkpointing, and alternative communications methods have been performed. Measurements on various aspects of RAID transaction processing performance are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Reaction of Nitric Oxide with Cell-free Hemoglobin Based Oxygen Carriers: Physiological Implications (1997)

Changes in mean arterial pressure (MAP) were monitored in rats following 50% isovolemic exchange transfusion (ET) with a solution of either (1) human hemoglobin cross-linked with diaspirin between the a subunits at lysine 99 (aa-Hb), or (2) bovine hemoglobin surface modified by conjugation with methoxypolyethylene glycol (PEG-Hb). Within seconds of the start of ET with as-Hb solution, MAP is observed to increase at least 25 mm Hg above the pre-exchange baseline value. This increase in MAP persists for at least two hours. In contrast, no significant increase in MAP is observed subsequent to 50% ET with a solution of PEG-Hb. In order to test the hypothesis that this difference in MAP response may be due to differences in reactivity between these hemoglobins and the endothelium-derived relaxing factor nitric oxide (NO), bimolecular association rate constants, dissociation rate constants, and overall equilibrium binding constants were determined for the reaction of these two hemoglobins with NO. Additionally, the bimolecular rate constants for the reaction of NO with the oxygen-bound form of these hemoglobins were also measured. No significant difference was observed between as-Hb and PEG-Hb in either the bimolecular NO association rate or the rate of NO-induced oxidation in vitro. PEG-Hb binds NO a factor of two more tightly than aa—Hb at equilibrium. This suggests that some property of PEG-Hb either prevents reaction with NO in vivo, or prevents increases in MAP despite NO scavenging. These results also suggest that the increase in MAP observed upon ET with as-Hb may not be the result of NO scavenging, but rather due to alternative physiologic mechanisms.
Quantum particle in a box with moving walls (1993)

The analytical expressions for the energy gain and transition probabilities between energy levels of a nonrelativistic quantum particle confined in a box with uniformly moving walls, including the cases of adiabatic motion and a sudden change of the size of the box was obtained.
Studies on new acid proteases from Scytalidium lignicolum ATCC 24568. Part IX. Additional evidence for the identity of Scytalidium lignicolum acid proteinases with the carboxyl proteinase group (1986)

S. lignicolum acid proteinases A-l, A-2, and B (S-PI-insensitive) were examined for the structure of the active sites by the method of Nakatani using PAD as a probe. We attempted to screen for substances that release zinc(II)-PAD from the complex of zinc(II)-PAD-S-PI-insensitive acid proteinases. Angiotensin I released zinc(II)-PAD from the complex as well as from the complex of S-PI-sensitive acid proteinases. Angiotensin I is a good substrate for these enzymes regardless of S-PI-sensitivity. These results suggest that the two carboxyl groups capable of binding to zinc(II)-PAD are at the active site regions of S. lignicolum enzymes and that they are involved in their catalytic actions.
SU‐E‐T‐549: Modeling Relative Biological Effectiveness of Protons for Radiation Induced Brain Necrosis (2015)

Purpose: To develop a model of the relative biological effectiveness (RBE) of protons as a function of dose and linear energy transfer (LET) for induction of brain necrosis using clinical data. Methods: In this study, treatment planning information was exported from a clinical treatment planning system (TPS) and used to construct a detailed Monte Carlo model of the patient and the beam delivery system. The physical proton dose and LET were computed in each voxel of the patient volume using Monte Carlo particle transport. A follow‐up magnetic resonance imaging (MRI) study registered to the treatment planning CT was used to determine the region of the necrosis in the brain volume. Both, the whole brain and the necrosis volumes were segmented from the computed tomography (CT) dataset using the contours drawn by a physician and the corresponding voxels were binned with respect to dose and LET. The brain necrosis probability was computed as a function of dose and LET by dividing the total volume of all necrosis voxels with a given dose and LET with the corresponding total brain volume resulting in a set of NTCP‐like curves (probability as a function of dose parameterized by LET). Results: The resulting model shows dependence on both dose and LET indicating the weakness of the constant RBE model for describing the brain toxicity. To the best of our knowledge the constant RBE model is currently used in all clinical applications which may Result in increased rate of brain toxicities in patients treated with protons. Conclusion: Further studies are needed to develop more accurate brain toxicity models for patients treated with protons and other heavy ions.
Immunological and Molecular Analyses of the <i>Borrelia hermsii</i> Factor H and Factor H-Like Protein 1 Binding Protein, FhbA: Demonstration of Its Utility as a Diagnostic Marker and Epidemiological Tool for Tick-Borne Relapsing Fever (2006)

ABSTRACT It has been demonstrated that Borrelia hermsii , a causative agent of relapsing fever, produces a factor H (FH) and FH-like protein 1 (FHL-1) binding protein. The binding protein has been designated FhbA. To determine if FH/FHL-1 binding is widespread among B. hermsii isolates, a diverse panel of strains was tested for the FH/FHL-1 binding phenotype and FhbA production. Most isolates (23/24) produced FhbA and bound FH/FHL-1. Potential variation in FhbA among isolates was analyzed by DNA sequence analyses. Two genetically distinct FhbA types, designated fhbA1 and fhbA2 , were delineated, and type-specific PCR primers were generated to allow for rapid differentiation. Pulsed-field gel electrophoresis and hybridization analyses demonstrated that all isolates that possess the gene carry it on a 200-kb linear plasmid (lp200), whereas isolates that lack the gene lack lp200 and instead carry an lp170. To determine if FhbA is antigenic during infection and to assess the specificity of the response, recombinant FhbA1 (rFhbA1) and rFhbA2 were screened with serum from infected mice and humans. FhbA was found to be expressed and antigenic and to elicit a potentially type-specific FhbA response. To localize the epitopes of FhbA1 and FhbA2, truncations were generated and screened with infection serum. The epitopes were determined to be conformationally defined. Collectively, these analyses indicate that FH/FHL-1 binding is a widespread virulence mechanism for B. hermsii and provide insight into the genetic and antigenic structure of FhbA. The data also have potential implications for understanding the epidemiology of relapsing fever in North America and can be applied to the future development of species-specific diagnostic tools.
Neural network-based reputation model in a distributed system (2004)

Current centralized trust models are inappropriate to apply in a large distributed multi-agent system, due to various evaluation models and partial observations in local level reputation management. This paper proposes a distributed reputation management structure, and develops a global reputation model. The global reputation model is a novel application of neural network techniques in distributed reputation evaluations. The experimental results showed that the model has robust performance under various estimation accuracy requirements. More important, the model is adaptive to changes in distributed system structures and in local reputation evaluations.