gebhart/patrepeval huggingface dataset:
Antigingivitis efficacy of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice in subjects previously nonresponsive to a triclosan/copolymer dentifrice. (2005)

Antimicrobial agents, such as stannous fluoride and triclosan, have been incorporated into dentifrice formulations and shown to be effective in the prevention and reduction of gingivitis. However, not all subjects respond to treatment. The objective of this study was to assess the antigingivitis efficacy of a 0.454% stannous fluoride/sodium hexametaphosphate dentifrice among subjects who were identified as nonresponsive or minimally responsive to a sodium fluoride/triclosan/copolymer dentifrice. This was a 12-week, examiner-blind, single-center study. Forty-one subjects with no or minimal gingivitis response to 6 months of use of a sodium fluoride/triclosan/copolymer dentifrice were enrolled in this study and 38 of them provided complete data. All subjects were provided with a 0.454% stannous fluoride/sodium hexametaphosphate dentifrice to use over the next 3 months (12 weeks). Subjects were instructed to brush twice daily for 60 seconds using their assigned product. Toothbrushing was supervised for 3 days of each week. Clinical examinations using the Löe-Silness Gingival Index were performed at 6 and 12 weeks posttreatment. The 6-month scores after the use of the sodium fluoride/triclosan/copolymer dentifrice served as the baseline. After 12 weeks of product use, participants had statistically significantly less gingivitis by 54% and statistically significantly less bleeding by 55% on average compared to baseline. No adverse oral soft tissue effects were reported in the study. This study demonstrated that the use of an experimental 0.454% stannous fluoride/sodium hexametaphosphate dentifrice over a 12-week period provides a statistically significant and clinically relevant effect in the control of gingivitis among subjects who previously did not respond to 6 months of use of a sodium fluoride/triclosan/copolymer dentifrice.
Improved use of oxygen scavengers to stabilize the colour of retail-ready meat cuts stored in modified atmospheres (2002)

Abstract A series of three experiments were conducted to develop a retail packaging system suitable for use in centralized meat processing and packaging operations using modified atmosphere master packaging (MAP) of display-ready beef and pork cuts. It was shown that oxygen (O2) scavengers were needed inside retail trays, lidded or over-wrapped trays could be used with equal success but inclusion of a grid inside the retail tray was not required. It was established that a minimum of eight O2 scavengers with an O2 absorption rate high enough to achieve an O2 half-life of 0.6–0.7 h in the pack atmosphere were needed where the O2 concentration could otherwise remain ≤500 ppm at any time during storage. Composite results from these experiments clearly showed that the best performance resulted from use of hard plastic retail trays containing eight O2 scavengers, with high O2 absorption rate, when placed underneath an absorbent pad and over-wrapped with an O2 permeable film. Small holes in two corners of the O2 permeable film to permit free exchange of atmospheres within the retail packages facilitated O2 reduction during MAP storage.
Genome-Wide Linkage Analysis of <i>TMPRSS2-ERG</i> Fusion in Familial Prostate Cancer (2009)

Fusion of the 5'-untranslated region of androgen-regulated TMPRSS2 promoter with ETS transcription factor family members is found frequently in prostate cancers, and recent work suggests that the most common TMPRSS2-ERG fusion is associated with an aggressive clinical phenotype compared with fusion-negative prostate cancer. Thus far, analysis of the fusion has been limited to sporadic cases of prostate cancer. In the current study, we explore for an enrichment of TMPRSS2-ERG fusion in familial prostate cancer. TMPRSS2-ERG fusion was identified using a break-apart fluorescence in situ hybridization assay on tissue microarrays. Presence of TMPRSS2-ERG fusion was associated with higher Gleason scores (P = 0.027). Of 75 patients with established history of prostate cancer, we detected the TMPRSS2-ERG fusion in 44 (59%) patients. Almost three quarters (73%) of fusion-positive patients accumulated within 16 specific families whereas only 27% were single fusion-positive cases within one family. Based on reported prevalence rates, we calculated a sibling recurrence risk ratio of up to 18.9. A subset (63%) of families with uniformly TMPRSS2-ERG-positive prostate cancer underwent a genome-wide linkage scan at 500 markers. This revealed several loci located on chromosomes #9, #18, and X that were suggestive of linkage to the TMPRSS2-ERG fusion-positive prostate cancer phenotype with linkage-of-disease scores up to 2.16 and nonparametric linkage scores up to 2.77. This suggests the presence of an inherited susceptibility to developing the TMPRSS2-ERG fusion. Given the association of TMPRSS2-ERG fusion and aggressive prostate cancer, close surveillance of relatives of patients with established fusion-positive prostate cancer or a family history of prostate cancer in general would be warranted.
Compact representation of autonomic stimulation on cardiorespiratory signals by principal component analysis (2002)

Multiparametric monitoring of patients allows a better comprehension of their clinical evolution, but yields a large amount of data, difficult to be analysed and compared: this makes desirable a compact data interpretation and representation. The authors describe the application of principal component analysis (PCA), a technique allowing the reduction of the data set dimensionality, to a series of parameters extracted from cardiovascular (ECG, systemic arterial pressure) and respiratory signals. An x-y plot, built up with the first two principal components (PC's), provides a compact representation of the beat-to-beat variation of the signal features as compared with basal conditions, during different autonomic stimulations (passive tilt test Valsalva manoeuvre, handgrip test baroreflex stimulation by phenylephrine administration).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
3-methylcholanthrene-induced monooxygenase (O-deethylation) activity of human lymphocytes. (1977)

With a direct fluorescence assay, the levels of mixed-function oxidase activity were determined in mitogen-activated human lymphocytes. The O-deethylation of ethoxyresorufin to resorufin was used to quantitate mixed-function oxidase activity. Ethoxyresorufin O-deethylase activity was low to nondetectable in noninduced, mitogen-activated cells, but it was readily detected in 3-methylcholanthrene, mitogen-activated lymphocytes. The activity was: (a) dependent on assay time and number of lymphocytes; (b) dependent on the presence of reduced nicotinamide adenine dinucleotide phosphate; (c) stable to freezing at -80 degrees for at least 2 weeks; (d) reproducibly detected in duplicate samples of blood from one individual when cultured and assayed at the same time; but (e) quite variable in samples of blood from one individual at different times. Since in hepatic and pulmonary tissue of model animal systems ethoxyresorufin is a specific substrate for cytochrome P-448-associated monooxygenases, the use of this chemical could proffer an assay that specifically measures human cytochrome P-448-associated activity.
A general formula for handoff rate in PCS networks (1998)

This paper presents a formula for the computation of handoff rate in PCS networks under generally distributed call holding times and generally distributed cell residence times. This formula can be used to study the handoff traffic rate. It shows that applying the exponential distribution underestimate the handoff traffic rate, hence the computed handoff call blocking probability will be lower than the actual handoff call blocking probability. This suggests the necessity of the sensitivity study with respect to the variance of channel occupancy time in the PCS network analysis and design.
Epigenetics and depression: current challenges and new therapeutic options (2010)

Because of the complex causal factors leading to depression, epigenetics is of considerable interest for the understanding of early life stress in depression. The current research regarding epigenetic pharmaceuticals is promising and deserves further attention in depression and psychiatry in general, and may strike out new ways towards individually tailored therapies.
Cardiac magnetic resonance imaging in pulmonary arterial hypertension (2013)

Cardiac magnetic resonance imaging (CMRI) provides accurate information about right ventricular (RV) mass, RV volumes and other markers of RV function. CMRI is proving to be a particularly useful tool in pulmonary arterial hypertension (PAH), as measures of RV function have been shown to be prognostic of long-term outcomes in this disease. Changes in RV function can also provide important information about a patient's disease course and response to treatment. As CMRI is noninvasive it can be used to regularly monitor patients with PAH, which is an important advantage over invasive right heart catheterisation. This review will explore the use of CMRI in the context of existing monitoring tools for PAH and will explore the forthcoming developments that are likely to be important in the future monitoring of patients with PAH.
Analysis for piezoresistive property of heavily-doped polysilicon with upper and lower bounds (2010)

This paper proposed an analysis for the piezoresistive property of heavily-doped polycrystalline silicon (polysilicon) with upper and lower bounds derived using the fundamental piezoresistive coefficients of single-crystalline silicon (SCS). The analysis is applicable to the polysilicon that the piezoresistive effect in grain boundaries is negligible and the orientations of the SCS grains are completely random. For deriving the upper and lower bounds, the analysis employed two approximation models on the basis of two extreme assumptions of uniform stress and fractional change in resistivity in each SCS grain of polysilicon. The fundamental piezoresistive coefficients of polysilicon derived from these models were successfully defined as the upper and lower bounds, based on the elastic theories in the micromechanics filed. The applicability of the analysis was discussed by comparing the derived upper and lower bounds with the piezoresistive property of heavily-doped polysilicon measured in some previous works. The measured piezoresistive property of both p-type and n-type polysilicon lay within the theoretical possible range between the upper and lower bounds at the impurity concentration of 1019 cm−3 levels, which suggested the applicability of the proposed analysis for the piezoresistive property of heavily-doped polysilicon.
Electrochemical oxidation of As(<scp>iii</scp>) on Pd immobilized Pt surface: kinetics and sensing performance (2018)

Pd nanoparticles were electrochemically immobilized on a Pt surface in the presence of sodium dodecyl sulfate (SDS) molecules to study the electrokinetics of arsenite oxidation reactions and the corresponding sensing activities. The X-ray photoelectron spectroscopy (XPS) analysis showed that on the Pt surface, Pd atoms exist as adatoms and the contents of Pd(0) and Pd(ii) were 75.72 and 24.28 at%, respectively, and the particle sizes were in the range of 61-145 nm. The experimental results revealed that the catalytic efficiency as well as the charge transfer resistance (at the redox potential of the Fe(ii)/Fe(iii) couple) increased in the order of Pt < Pt-Pd < Pt-Pd<sub>sds</sub>. A Pt-Pd<sub>sds</sub> electrode exhibited an open circuit potential (OCP) of 0.65 V in acidic conditions; however, when 50.0 mM NaAsO<sub>2</sub> was present, the OCP value shifted to 0.42 V. It has been projected that the As(iii) oxidation proceeds using a sequential pathway: As(iii) → As(iv) → As(v). After optimization of the square wave voltammetric data, the limits of detection of As(iii) were obtained as 1.3 μg L<sup>-1</sup> and 0.2 μg L<sup>-1</sup> when the surface modification of the Pt surface was executed with Pd particles in the absence and presence of the SDS surfactant, respectively. Finally, real samples were analyzed with excellent recovery performance.
A DNA Mimic Made of Non‐Nucleosidic Phenanthrene Building Blocks (2005)

Stable stacking. DNA mimics have been prepared from simple, non-nucleosidic building blocks. These oligonucleotides, which contain extended stretches of phenanthrene derivatives, form stable hybrids. The phenanthrene residues contribute to the stability of the duplex through interstrand stacking interactions. The hybrids adopt an overall B-form structure, thus mimicking natural DNA. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2005/z500366_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
155. Studies of trifluoroacetic acid. Part III. The use of trifluoroacetic anhydride in the synthesis of aromatic ketones and sulphones (1951)

E. J. Bourne, M. Stacey, J. C. Tatlow and J. M. Tedder, J. Chem. Soc., 1951, 718 DOI: 10.1039/JR9510000718
Comparison of umbilical cord occlusion methods: Radiofrequency ablation versus laser photocoagulation (2017)

Despite clear technical advantages of RFA compared with laser, we found that RFA appeared to be associated with increased risk of post-procedure fetal demise. Further studies should be conducted to confirm these findings.
ChemInform Abstract: The Total Synthesis of the Natural Product Endothelin Converting Enzyme (ECE) Inhibitor, WS75624 B. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Calculation of Drug Lipophilicity: The Hydrophobic Fragmental Constant Approach (1992)

Importance of lipophilicity in QSAR studies calculation of log P values intramolecular aspects of lipophilitic behaviour tables of fragmental constants log-P calculations for selected drugs.
<title>Evanescent Bessel light beams</title> (2001)

The spatial structure and polarization of evanescent Bessel light beams excited in an optically less dense medium in conditions of total internal reflection is investigated in detail. TH- and TE-polarized Bessel beams and also their linear superposition are considered. The Pointing vector of evanescent BLBs are calculated. An existence of azimuthal and radial components of the energy flow and also of its z- component, oscillating with the radial coordinate, is established. The structure of the central maximum of a zero- order evanescent BLB is investigated and its diameter is shown being able to be reduced to submicron sizes.
Direct Wafer Bonded Abrupt Junction Tunnel Diodes (2004)

Abrupt junction tunnel diodes have been fabricated using hydrophobic direct wafer bonding to join together highly n- and p-type doped wafers. Low reverse resistance backward diodes were achieved. The reverse bias behavior of the diodes is purely ohmic with a total reverse resistance of 0.0015 Ω cm2, which produces a reverse voltage of 150 mV at 100 A/cm2. Although Esaki tunneling is observed under forward bias, there is no observed negative differential resistance due to high excess current. The current work is the first step in creating low-loss stacked diode structures for high blocking voltage electric power applications. © 2004 The Electrochemical Society. All rights reserved.
Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action (2005)

We enrolled six patients suffering from refractory chronic cluster headache in a pilot trial of neurostimulation of the ipsilateral ventroposterior hypothalamus using the stereotactic coordinates published previously. After the varying durations needed to determine optimal stimulation parameters and a mean follow-up of 14.5 months, the clinical outcome is excellent in three patients (two are pain-free; one has fewer than three attacks per month), but unsatisfactory in one patient, who only has had transient remissions. Mean voltage is 3.28 V, diplopia being the major factor limiting its increase. When the stimulator was switched off in one pain-free patient, attacks resumed after 3 months until it was turned on again. In one patient the implantation procedure had to be interrupted because of a panic attack with autonomic disturbances. Another patient died from an intracerebral haemorrhage that developed along the lead tract several hours after surgery; there were no other vascular changes on post-mortem examination. After 1 month, the hypothalamic stimulation induced resistance against the attack-triggering agent nitroglycerin and tended to increase pain thresholds at extracephalic, but not at cephalic, sites. It had no detectable effect on neurohypophyseal hormones or melatonin excretion. We conclude that hypothalamic stimulation has remarkable efficacy in most, but not all, patients with treatment-resistant chronic cluster headache. Its efficacy is not due to a simple analgesic effect or to hormonal changes. Intracerebral haemorrhage cannot be neglected in the risk evaluation of the procedure. Whether it might be more prevalent than in deep-brain stimulation for movement disorders remains to be determined.
India ink: A potential clinically applicable EPR oximetry probe (1994)

Using a material that already is in widespread use in humans, India ink, the first EPR measurements in a human have been made, using the India ink in a pre-existing tattoo. The EPR spectra of India ink are very sensitive to the partial pressure of oxygen (pO2), thereby making it feasible to use this approach to measure pO2 in tissues in patients. This potentially provides a means to measure this parameter directly with a sensitivity, accuracy, and repeatability that have not been available previously, and thereby to be able to individualize and guide treatment of diseases such as cancer and peripheral vascular insufficiency.
Room-Temperature Phosphorescence Studies of Epoxy Resin Cured by an Aromatic Diamine (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRoom-Temperature Phosphorescence Studies of Epoxy Resin Cured by an Aromatic DiamineJian Cheng Song and Chong Sook Paik SungCite this: Macromolecules 1995, 28, 16, 5581–5584Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/ma00120a024https://doi.org/10.1021/ma00120a024research-articleACS PublicationsRequest reuse permissionsArticle Views241Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Immunocytochemical analysis of BAFF expression in salivary epithelilal cells from minor salivary glands (2011)

<b>Copyright information:</b>Taken from "B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome"Arthritis Research & Therapy 2006;8(2):R51-R51.Published online 28 Feb 2006PMCID:PMC1526588. Positive staining for B cell-activating factor (BAFF) 48 hours after stimulation with IFN-α (2,400 U/ml) and with IFN-γ (5 ng/ml) was markedly enhanced compared with baseline . Negative control with polyclonal rat immunoglobulin.
Adjuvant Radiotherapy for Thymic Epithelial Tumor (2007)

Postoperative radiation therapy to doses above 45 Gy may improve the disease-free and overall survival of patients with invasive thymoma, especially stage II. Thymic carcinoma has a worse prognosis.
A task difficulty—G stress experiment (1984)

This paper describes a study of methods to design manual tracking tasks. These tasks are to be used to help investigate performance changes as humans are subjected to G acceleration stress. The design of the tasks had to meet two criteria. First, the tasks were required to differ from one another in terms of subjective difficulty (as well as showing a performance change empirically). Secondly, each task had to be sensitive enough to show performance changes in a stress/non-stress environment. The tasks used were of a sum of sines design approach which occurs commonly in manual control theory. The type of environmental stress considered in this study was a + Gz acceleration to which aircraft pilots are exposed during flight manoeuvres. The experiment was conducted on the Dynamic Environmental Simulator (D.E.S.), a three degree of freedom human centrifuge located at the Air Force Aerospace Medical Research Laboratory at Wright Patterson Air Force Base, Ohio.
Wound Contraction Is Attenuated by Fasudil Inhibition of Rho-Associated Kinase (2011)

There is growing evidence that the RhoA/Rho-associated kinase pathway plays an important role in wound healing and scar contracture. The authors present data showing that inhibition of Rho-associated kinase hinders fibroblast contractility and may be beneficial in preventing scar contracture.
A team recommendation system and outcome prediction for the game of cricket (2018)

Predicting the outcome of a game using players strength and weakness against the players of the opponent team by considering the statistics of a set of matches played by players helps captain and coaches to select the team and order the players. In this paper, we propose a supervised learning method using SVM model with linear, and nonlinear poly and RBF kernals to predict the outcome of the game against particular side by grouping the players at different levels in the order of play for both the teams. The comparison among different groups of players at same level gives the order of groups which contributes to winning probability. we also propose to develop a system which recommends a player for a specific role in a team by considering the past performances. we achieve this by finding the similar players by clustering all the players using k-means clustering and finding the five nearest players using k nearest neighbor (KNN) classifier. We calculate the ranking index for players using the game and players statistics extracted from a particular tournament. Experimental results demonstrate that, the n-dimensional data considered for modeling is not linearly separable. Hence the nonlinear SVM with RBF kernel outperforms from the linear and poly kernel. SVM with RFB kernel yields the accuracy of 75, precision of 83.5 and recall rate of 62.5. So we recommend the use of SVM with RBF kernel for game outcome prediction.