gebhart/patrepeval huggingface dataset:
The Peripheral Nerve Allograft in the Primate Immunosuppressed with Cyclosporin A (1992)

Isometric contractile function was evaluated in primates receiving peripheral nerve allografts and autografts. Twelve adult male cynomolgus monkeys received both sural nerve allografts and autografts to the ulnar nerve in opposite forearms. Half the animals received Cyclosporin A (CsA) immunosuppression (25 mg/kg per day); the remaining animals received placebo. One year following nerve engraftment, isometric contractile muscle function was evaluated in reinnervated abductor digiti quinti and intact abductor pollicis brevis muscles. Maximal twitch tension (Pt), tetanic tension (P(o)), time to peak tension (tpt), rate of rise of twitch tension (DP/dt), and muscle fatigue were evaluated at optimal muscle length (L(o)). All reinnervated muscles distal to nerve autografts and allografts in both Cyclosporin A-immunosuppressed and placebo-treated animals generated equivalent maximal twitch tension, tetanic tension, and time to peak tension, with no significant difference between groups (p > 0.05 by ANOVA). There was a tendency toward increased muscle fatiguability in Cyclosporin A-treated animals (p > 0.05). However, the rate of rise of twitch tension was significantly faster in the reinnervated and intact muscles of Cyclosporin A-treated primates (p < 0.05). Evidence of excellent functional reinnervation across nerve allografts and autografts similar to that seen in histologic and electrophysiologic studies was noted. Cyclosporin A immunosuppression did not significantly enhance recovery of muscle function distal to nerve allografts in this model.
International Conference on Inflammopharmacology – VIII Side-Effects of Anti-Inflammatory Drugs Symposium (2003)

The International Conference on Inflammopharmacology with VIII Side-Effects of Anti-Inflammatory Drugs Symposium was held in Edinburgh, UK on 22 - 24 April 2003. The meeting was well attended, involving approximately 80 rheumatologists, pharmacologists and research scientists from both academia and industry with a special interest in osteoarthritis. Although few new drugs emerged at the meeting as treatment options for osteoarthritis, exciting data on the latest advances in novel inhibitors of the pathways involved in the pathogenesis of osteoarthritis were presented. This report describes recent clinical experiences with the unique lipoxygenase/cyclooxygenase inhibitor licofelone (ML3000; EuroAlliance, a partnership of Merckle [Germany], Alfa Wassermann [Italy] and Lácer [Spain]) and the latest developments in nitric oxide-donating non-steroidal anti-inflammatory drugs NMI-1093 and NMI1089 (Nitromed, Inc., USA) and AZD3582 (AstraZeneca, Sweden).
Pseudomonas antimicrobica Attafuah and Bradbury 1990 is a junior synonym of Burkholderia gladioli (Severini 1913) Yabuuchi et al. 1993. (2000)

Comparison of the 16S rDNA sequence of Pseudomonas antimicrobica LMG 18920T with published 16S rDNA sequences from other pseudomonads indicated that Pseudomonas antimicrobica belongs to the genus Burkholderia, with Burkholderia gladioli, Burkholderia glumae and Burkholderia plantarii as its closest neighbours. DNA-DNA hybridizations confirmed that Pseudomonas antimicrobica and Burkholderia gladioli represent the same species. Strain LMG 18920T and other Burkholderia gladioli strains were also indistinguishable by SDS-PAGE of whole-cell proteins and had similar biochemical characteristics. The whole-cell fatty acid composition, however, was different from that of other Burkholderia gladioli strains. It is concluded that Pseudomonas antimicrobica is a later synonym of Burkholderia gladioli. As Burkholderia gladioli is known to cause infections in patients with cystic fibrosis and chronic granulomatous disease, the eventual use of strain LMG 18920T as a biological control agent should be approached with caution.
The Use of Imidazolium Ionic Liquids for the Formation and Stabilization of Ir<sup>0</sup> and Rh<sup>0</sup> Nanoparticles: Efficient Catalysts for the Hydrogenation of Arenes (2003)

Stable transition-metal nanoparticles of the type [M(0)](n) are easily accessible through the reduction of Ir(I) or Rh(III) compounds dissolved in "dry" 1-n-butyl-3-methylimidazolium hexafluorophosphate ionic liquid by molecular hydrogen. The formation of these [M(0)](n) nanoparticles is straightforward; they are prepared in dry ionic liquid whereas the presence of the water causes the partial decomposition of ionic liquid with the formation of phosphates, HF and transition-metal fluorides. Transmission electron microscopy (TEM) observations and X-ray diffraction analysis (XRD) show the formation of [Ir(0)](n) and [Rh(0)](n) nanoparticles with 2.0-2.5 nm in diameter. The isolated [M(0)](n) nanoparticles can be redispersed in the ionic liquid, in acetone or used in solventless conditions for the liquid-liquid biphasic, homogeneous or heterogeneous hydrogenation of arenes under mild reaction conditions (75 degrees C and 4 atm). The recovered iridium nanoparticles can be reused several times without any significant loss in catalytic activity. Unprecedented total turnover numbers (TTO) of 3509 in 32 h, for arene hydrogenation by nanoparticles catalysts, have been achieved in the reduction of benzene by the [Ir(0)](n) in solventless conditions. Contrarily, the recovered Rh(0) nanoparticles show significant agglomeration into large particles with a loss of catalytic activity. The hydrogenation of arenes containing functional groups, such as anisole, by the [Ir(0)](n) nanoparticles occurs with concomitant hydrogenolysis of the C-O bond, suggesting that these nanoparticles behave as "heterogeneous catalysts" rather than "homogeneous catalysts".
The use of multidimensional scaling techniques for revealing perceptual categories for complex stimuli in animals (1988)

A combination of operant conditioning and multidimensional scaling techniques for demonstrating natural perceptual categories for complex sounds in small birds are described. Birds are trained using operant conditioning procedures on either a same/different discrimination task or on a task requiring the detection of change in a repeating background. Response latencies are used to construct similarity matrices, and multidimensional scaling procedures are then used to produce spatial maps of complex sounds reflecting perceptual organization. Stimulus similarity is represented by spatial proximity. Stimulus groupings in multidimensional space indicate perceptual categories that can be confirmed by cluster analyses. These procedures have been used to study the perception of complex sounds such as bird calls and speech in small birds, but these techniques should also be useful in examining the perception of complex sounds in other animals. [Work supported by NIH.]
Colloidal Phase Separation of Concentrated PNIPAm Solutions (2007)

In the concentration range of 1-6 wt %, solutions of a thermosensitive polymer (poly-N-isopropylacrylamide (PNIPAm), Mw = 1.4 x 10(5) g.mol(-1)) are shown to phase separate in the form of dense stable colloids of nearly pure polymer. Diffuse wave spectroscopy and small-angle neutron scattering both provide consistent measurements of the colloidal size as a function of temperature. Results are in agreement with a Cahn regime of spinodal decomposition blocked at an early stage, prior to a growth that would lead to a macroscopic phase separation. [Early results of this work were presented at the 231st American Chemical Society National Meeting, Symposium on Amphiphilic Polymers, Atlanta, GA, 2006, March 26-30.].
Defect structures in metallic photonic crystals (1996)

We have investigated metallic photonic crystals built around a layer-by-layer geometry. Two different crystal structures (face-centered-tetragonal and tetragonal) were built and their properties were compared. We obtained rejection rates of 7–8 dB per layer from both metallic crystals. Defect modes created by removing rods resulted in high peak transmission (80%), and high quality factors (1740). Our measurements were in good agreement with theoretical simulations.
Unsaturated sulfoxides in organic synthesis: a new general furan synthesis (1992)

Furans have been efficiently synthesised by a three-step reaction sequence. Michael addition of keto esters to alkenyl sulfoxides followed by Pummerer rearrangement afforded the cyclic intermediates 11 in good yield. Treatment of the latter with 2-chloroperoxybenzoic acid led by oxidation and syn-elimination of the corresponding sulfoxide, to substituted furans.
Mechanical Damping in the Martensitic Phase of Cu-Al-Ni Crystals (1997)

Amplitude and frequency dependences of intrinsic damping have been studied in copper-aluminum-nickel (Cu-Al-Ni) single crystals in the martensitic state after different heat treatments. The measurements of intrinsic damping were performed by resonant and forced oscillation techniques in a range from infra-to ultrasonic frequencies. The conclusion is drawn that during aging in β-phase (200°C) the behavior of the pinning obstacles in the martensitic state at room temperature changes from highly mobile and forming atmospheres around the mobile defects, presumably dislocations, to rather immobile and homogeneously distributed in the bulk of the crystal. Observed regularities of the amplitude-dependent intrinsic damping do not correspond to the breakaway model of amplitude-dependent internal friction both for quenched and aged specimens. In contrast to the generally accepted point of view, a notable frequency dependence of the amplitude-dependent damping is revealed, especially in the case of quenched specimens. Short-range pinning points are considered as basic obstacles for dislocation motion in the quenched specimens. Two types of obstacles are supposed to form the amplitude frequency spectra of damping for the aged specimens: purely hysteretic or athermal, due to the presence of γ-precipitates, and thermally activated due to the existence of short-range pinning points.
Steroidal Sapogenins. X.<sup>1a</sup> Unsaturated 22-Isospirosten-3-ones<sup>1b,2</sup> (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroidal Sapogenins. X.1a Unsaturated 22-Isospirosten-3-ones1b,2R. Yashin, G. Rosenkranz, and Carl DjerassiCite this: J. Am. Chem. Soc. 1951, 73, 10, 4654–4657Publication Date (Print):October 1, 1951Publication History Published online1 May 2002Published inissue 1 October 1951https://pubs.acs.org/doi/10.1021/ja01154a047https://doi.org/10.1021/ja01154a047research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncationElectronic supplementary information (ESI) available: spectroscopic data for compounds 2 and 3. See http://www.rsc.org/suppdata/cc/b2/b212651f/ (2003)

Simplified analogues of the potent antimitotic marine macrolide spongistatin 1/altohyrtin A were synthesised and evaluated as growth inhibitory agents against a range of human tumour cell lines, including Taxol-resistant strains, revealing that E-ring dehydration leads to enhanced cytotoxicity at the low picomolar level while truncation of the side-chain at C46 results in a drastic decrease in activity.
Expression of cyclic nucleotide-gated channels in the rat medial vestibular nucleus (2005)

The role of cyclic nucleotide-gated (CNG) channels in sensory signal transduction in retinal and olfactory cells is widely recognized, but there is increasing evidence that they also play more general functions in the central nervous system as downstream effectors of cyclic nucleotides. Here, we demonstrate the expression of the alpha-subunit of rod- and olfactory-type CNG channels (CNG1 and CNG2, respectively) in the rat medial vestibular nucleus (MVN). Nested polymerase chain reaction revealed CNG channel mRNA in the MVN, and CNG1 and CNG2 proteins were also detected by Western blotting and immunohistochemistry. Finally, electrophysiological evidence is provided suggesting that CNG channels play a functional role in the MVN.
Alkyl(quinolin-8-yl)phosphine Oxides as Hemilabile Preligands for Palladium-Catalyzed Reactions (2014)

Preligands of quinolyl-substituted secondary phosphine oxides (SPOs, 2a–d) were prepared and characterized. The unique palladium complex 3, having a distorted-square-pyramidal structure, was obtained from the reaction of 2 equiv of 2c with Pd(COD)Cl2 or [Pd(μ2-Cl)(η3-allyl)]2. In the crystal structure of 3, an apical chloride ligand and a supramolecular tetradentate ligand composed of a deprotonated 2c′ and a neutral 2c′ were resolved (2c′: PA form of 2c). Intriguingly, the gas-phase optimized geometry of 3 converged to a distorted-square-planar structure, which was predicted by density functional calculations. The solid-state distorted-square-pyramidal structure of 3 can only be explained with the consideration of environmental effects (i.e., the electrostatic interactions between the surrounding molecules). As also evidenced by 31P NMR experiments performed in different deuterated solvents, the crystal structure of 3 is retained in solution. In the crystal structure of 3, a long Pd–Cl bond was analyzed by energy decomposition analysis, showing that the bond is dominated by electrostatic character. Furthermore, application of these SPOs using the Heck reaction shows good reactivity toward common aryl bromides. The hemilabile preligand 2c also tautomerizes to the competent ligand 2c′ for palladium-catalyzed three-component reactions.
Nutrient-dependent neuronal activation patterns in the nucleus of the solitary tract: a study using 3d modeling and neuronal density maps (2009)

International audience
Outcome of Patients with Chemotherapy Refractory and Early Progressive Diffuse Large B Cell Lymphoma After R-CHOP Treatment (2010)

Abstract Abstract 1751 Background: The addition of rituximab to CHOP (R-CHOP) has markedly improved the progression-free and overall survival of patients (pts) with diffuse large B cell lymphoma (DLBCL). Nevertheless, 9.5% of pts harbor lymphoma that is refractory to R-CHOP (Feugier et al) and 18–27% experience relapse after initial response (GELA and MINT trial). Aim: Assess outcome of pts with primary refractory and early relapsing DLBCL (within 3 months of CR/PR post completion of R-CHOP treatment). Patients and Methods: The BCCA Lymphoid Cancer Database identified 1126 pts diagnosed with DLBCL between December 2000 and September 2009. All ages and stages were included and primary treatment was R-CHOP in all pts. Results: 166 pts(15%) had primary refractory or early relapsing disease, of which 93 were age >70 y and too frail to have received > 2 cycles of R-CHOP. Of the remaining 73 pts, 33 (45%) had primary refractory lymphoma and 40 (55 %) relapsed within 3 months of achieving a CR/PR. Pt characteristics (n=73): median age 57 y; 68% male; stage I (4 %), II (16 %), III (19 %), IV (60 %); PS 0,1 (41 %) PS 2–4 (59 %); LDH elevated (58 %); IPI 0 (1 %), 1 (15 %), 2 (15 %), 3 (30 %), 4 (35 %), 5 (2 %). There were no differences in the clinical characteristics of pts with primary refractory versus early relapsing disease. Of the 73 pts, 37 (50%) were without serious co-morbidity and were able to be treated with a curative intent that included multi-agent salvage chemotherapy with a plan to proceed to high-dose tx and autologous stem cell transplantation (ASCT), whereas 36 pts had palliative tx or comfort care only. 10 pts did undergo ASCT (3 primary refractory, 7 early relapsers). The median overall survival for the 73 pts was 10 months with only 6 pts alive without evidence of disease (range 14–106 months). 5 of these 6 pts had relapsed early after initial CR/PR, while only 1 patient had primary refractory disease. 3 of these 6 pts had salvage treatment without ASCT and 3 with ASCT. Conclusion: Chemotherapy-refractory or early relapsed disease after R-CHOP has a very poor outcome with only anecdotal survivors independent of the intended treatment approach. Biologic workup of this group of patients is urgently needed with the intention of defining the molecular underpinnings of treatment resistance. Disclosures: Savage: Roche: Honoraria. Sehn:Roche: Honoraria, Research Funding.
Distributed auxiliary particle filters using selective gossip (2011)

This paper introduces a distributed auxiliary particle filter for target tracking in sensor networks. Nodes maintain a shared particle filter by coming to a consensus about the likelihoods associated with each particle using the selective gossip procedure. Selective gossip provides a mechanism to efficiently identify the particles with largest weights and focus communication on sharing these important weights. We demonstrate through simulations that the algorithm performs well; compared to state-of-the-art approaches it either significantly improves the accuracy at the expense of a small increase in communication overhead, or achieves comparable accuracy with much lower communication overhead.
Stereochemical Properties of Copper(II) Complexes of (<i>RS</i>)-3-Aminohexahydroazepine: Crystal and Molecular Structures of [(<i>R</i>)-3-Aminohexahydroazepine][(<i>S</i>)-3-aminohexahydroazepine]copper(II) Diperchlorate, [Cu(<i>R</i>-ahaz)(<i>S</i>-ahaz)](ClO4)2 and Related Complexes (1987)

Abstract Orange-red copper(II) complexes of (RS)-3-aminohexahydroazepine (=RS-ahaz), Cu(RS-ahaz)2X2·nH2O (X−=ClO4−, BF4−, NO3−, Br−, I−) were prepared, and the molecular structures of complex 1 (X−=ClO4−; n=0) and complex 2 (X−=Br−; n=2) were determined by the single-crystal X-ray diffraction method. The complex 1 has centrosymmetry, and the complex cation in 1 involves a pair of R- and S-ahaz (R- and S-ahaz refer to (R)-and (S)-3-aminohexahydroazepine) and takes a strict four-coordination geometry, so that 1 is formulated as [Cu(R-ahaz)(S-ahaz)](ClO4)2. The complex cation in 2 resembles closely that of 1, and 2 can be represented as [Cu(R-ahaz)(S-ahaz)]Br2·2H2O. The other orange-red complexes of RS-ahaz (X−=BF4−, NO3−, I−) were concluded to take similar strict four-coordinated structures. Blue-violet hetero-anion complexes Cu(RS-ahaz)2X(ClO4) were obtained from complex 1 and LiX (X−=Cl−, Br−). The crystal structure determination of Cu(RS-ahaz)2Br(ClO4) (=complex 3) revealed that 3 involves a pair of enantiomeric five-coordinated cations, [CuBr(R-ahaz)2]+ and [CuBr(S-ahaz)2]+, in the single crystal, whereby the ligand exchange which proceeds during the transformation from 1 to 3 is indicated.
Characterization of Middle Cerebral Artery Occlusion Infarct Development in the Rat Using Fast Nuclear Magnetic Resonance Proton Spectroscopic Imaging and Diffusion-Weighted Imaging (1998)

A nuclear magnetic resonance study of the middle cerebral artery occlusion in the rat is presented. Experiments were performed on seven animals before and after occlusion, which occurred in situ. The emphasis in this study was on evaluating rapid proton spectroscopic imaging. Data were acquired with experimental durations of between 4 and 15 minutes for a 32 by 32 spatial matrix, with 64 spectroscopic data points per spatial element. The spectroscopic data were interleaved with diffusion-weighted nuclear magnetic resonance water images of the same slice. The study was terminated at about 6 hours after occlusion. The brains were then frozen in liquid nitrogen for biochemical imaging. The results showed that the signal from N-acetyl aspartate decreased and that of lactate increased within the infarcted region. The temporal course of these intensity changes varied between animals. Nineteen cortical spreading depressions (CSD) were observed by electrophysiologic monitoring during the experiments. Of these, 11 could be unambiguously detected in the lactate images, and a further 3 were on the threshold of detectability. As only a single slice could be examined, it is possible that the centers of depression for the remaining 6 CSD were outside the slice. To the authors' knowledge, this is the first report of the measurement of CSD using proton spectroscopic imaging. Thus, it is shown that this method is valuable not only in following the continuous evolution of proton metabolites with a good spatial and temporal resolution, but also in observing transient phenomena which are believed to play an important role in the expansion of the infarcted territory.
Software Power Optimization via Post-Link-Time Binary Rewriting (2001)

It is well known that compiler optimizations can significantly reduce the energy usage of a program. However, the traditional model of compilation imposes inherent limits on the extent of code optimization possible at compile time. In particular, analyses and optimizations are typically limited to individual procedures, and hence cannot cross procedural and module boundaries as well as the boundaries between application and library code. These limitations can be overcome by carrying out additional code optimization on the object file obtained after linking has been carried out. These optimizations are complementary to those carried out by the compiler. Our experiments indicate that significant improvements in energy usage can be obtained via post-link-time code optimization, even for programs that have been subjected to extensive compile-time optimization. 1 Motivation The amount of energy consumed during program execution is becoming an increasingly important concern for a wide spec...
A New Integrated Ultrasound System for Shockwave Lithotripsy (2006)

This study shows that the concept of an integrated transducer distant from the shockwave focus is feasible. Transducer elevation, which is accompanied by shockwave shadowing and early transducer failure, is avoided by employing a dedicated transducer design.
ChemInform Abstract: New Efficient Syntheses of α‐Difluoromethyl‐ and α‐ Trifluoromethyl‐ornithine. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.