gebhart/patrepeval huggingface dataset:
175. THE ROLE OF PROPROTEIN CONVERTASE 6 DURING DECIDUALIZATION: REGULATION OF BONE MORPHOGENETIC PROTEIN 2 ACTIVATION (2009)

Proprotein convertase 5/6 (PC6), a member of the proprotein convertase (PC) family, is a critical endometrial factor for implantation. PC6 is up-regulated in the endometrium specifically at implantation in association with epithelial differentiation (in human and monkey) and stromal cell decidualization (in the mouse, human and monkey). PC6 is the only PC member that was significantly up-regulated during decidualization. Knockdown of PC6 inhibits decidualization. PCs function by converting a range of important precursor proteins into their bioactive forms. One group of such proteins is the transforming growth factor beta (TGF-beta) superfamily proteins. They are first synthesized as larger biologically inactive precursors, and then are processed by PCs into their active forms. Bone morphogenetic protein 2 (BMP2) is a TGF-beta superfamily member and demonstrated to be essential for decidualization. We hypothesized that BMP2 is one of the proteins that PC6 activates during decidualization. Freshly isolated stromal cells from human endometrium were decidualized in culture with and without inhibition of PC6 activity. The full-length (precursor, non-active) and processed (activated) forms of BMP2 were determined in cellular lysates and media. The precursor form of BMP2 was reduced whereas the active form was increased during decidualization. Inhibition of PC6 activity inhibited decidualization, and this inhibition was accompanied by a total inhibition of the production of active BMP2. To further confirm the role of PC6 in activating BMP2 in decidualization, active BMP2 was added into cells and the decidualization arrest caused by PC6 inhibition was partially rescued. This study demonstrated that PC6 regulates decidualization by activating molecules such as BMP2 that are essential for decidualization.
Myocardial Function Imaging in Echocardiography Using Deep Learning (2021)

Deformation imaging in echocardiography has been shown to have better diagnostic and prognostic value than conventional anatomical measures such as ejection fraction. However, despite clinical availability and demonstrated efficacy, everyday clinical use remains limited at many hospitals. The reasons are complex, but practical robustness has been questioned, and a large inter-vendor variability has been demonstrated. In this work, we propose a novel deep learning based framework for motion estimation in echocardiography, and use this to fully automate myocardial function imaging. A motion estimator was developed based on a PWC-Net architecture, which achieved an average end point error of (0.06±0.04) mm per frame using simulated data from an open access database, on par or better compared to previously reported state of the art. We further demonstrate unique adaptability to image artifacts such as signal dropouts, made possible using trained models that incorporate relevant image augmentations. Further, a fully automatic pipeline consisting of cardiac view classification, event detection, myocardial segmentation and motion estimation was developed and used to estimate left ventricular longitudinal strain in vivo. The method showed promise by achieving a mean deviation of (-0.7±1.6)% compared to a semi-automatic commercial solution for N=30 patients with relevant disease, within the expected limits of agreement. We thus believe that learning-based motion estimation can facilitate extended use of strain imaging in clinical practice.
48.1: LTPS TFTs with Metal Electrodes Formed by Inkjet Printing Technology (2006)

Abstract Metal electrodes for low‐temperature polycrystalline‐silicon (LTPS) p‐channel thin‐film‐transistors (TFTs) have been fabricated employing an inkjet technique. This technique has the potential to reduce device fabrication costs and energy consumption during the device fabrication. We have developed a fine‐patterning technique employing the inkjet technique that is capable of producing metal lines with several μm widths by carefully controlling micro‐liquid behavior and surface wettability. TFTs employing the inkjet technique show good performance and reliability as same as conventional LTPS TFTs. These results show that the inkjet technique can be used to fabricate high‐performance LTPS TFTs at low cost.
Microdetermination of Methylenedioxyl or Combined Formaldehyde Groups (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicrodetermination of Methylenedioxyl or Combined Formaldehyde GroupsMorton. BerozaCite this: Anal. Chem. 1954, 26, 12, 1970–1973Publication Date (Print):December 1, 1954Publication History Published online1 May 2002Published inissue 1 December 1954https://pubs.acs.org/doi/10.1021/ac60096a034https://doi.org/10.1021/ac60096a034research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-HLA class I antibody response. (1992)

Our earlier reports demonstrated that Cynomolgus macaques vaccinated with either inactivated partially purified simian immunodeficiency virus (SIV), fixed SIV-infected C8166 (a human T lymphoblastoid cell line) cells, or fixed uninfected C8166 cells can be protected against a challenge infection with the 32H isolate of SIVmac 251 (grown in C8166) (Stott, E. J., W. L. Chan, K. H. G. Mills, M. Page, F. Taffs, M. Cranage, P. Greenway, and P. Kitchin. 1990. Lancet. 336:1538; Stott, E. J., P. A. Kitchin, M. Page, B. Flanagan, L. F. Taffs, W. L. Chan, K. H. G. Mills, P. Silvera, and A. Rodgers. 1991. Nature [Lond.]. 353:393). Protection is correlated with the levels of antibody response to cellular antigens in the human cells from which the virus immunogen was grown. However, the mechanism of protection is unclear. We report here the analysis of sera from these protected monkeys and demonstrate that there is positive correlation of protection with antibody response to the HLA class I molecule.
Evanescent Waves and the Electromagnetic Field of a Moving Charged Particle* (1971)

An angular-spectrum representation is obtained of the electromagnetic field in a homogeneous medium, arising from any prescribed motion of a charged particle in a plane. The field on either side of the plane of motion is expressed as a superposition of monochromatic waves in general, homogeneous as well as evanescent ones. The homogeneous waves are propagated away from the plane of motion of the particle, the evanescent ones decay exponentially with increasing distance from this plane. For each plane wave, the appropriate dispersion relation is satisfied and hence the representation is a true mode expansion in each of the two half-spaces. The results are illustrated by considering the field of a uniformly moving charged particle. In free space, the Coulomb field of the particle, as would be observed in a fixed laboratory system, is shown to arise from the superposition of evanescent waves to which the moving particle gives rise. The main formulas relating to the Čerenkov field both above and below threshold are also obtained, as an illustration of this technique.
Peptidos sinteticos en la induccion de la respuesta inmune humoral: obtencion de anticuerpos neutralizantes frente al vih-1 (1993)

La utilizacion de inmunogenos pectidicos que presentan una secuencia reconocida por los linfocitos t colinearmente unida a una secuencia reconocida por los linfocitos b (db), es uno de los metodos mas recientes de obtencion de anticuerpos anti-hapteno. La construccion de tales inmunogenos ha de tener en cuenta la posicion relativa de los determinantes, ya que es preferible aquella orientacion que origine una estructura con el db externamente, accesible a los anticuerpos, y con el dt oculto. En el presente trabajo esta configuracion ha sido del tipo dt-db. Por otro lado, entre ambos determinantes deben existir puntos de corte que permitan la liberacion del dt durante el procesamiento. Ademas de los inmunogenos que presentan los determinantes unidos, la utilizacion de mezclas (dt + db), es un nuevo metodo eficaz y de gran simplicidad que permite la obtencion de anticuerpos sin tener que unir los haptencs a un dt o a una proteina portadora. Dentro de las proteinas del vih-1, el pectido vpr20 (aminoacidos 66-80 de vpr) se comporta como dt en el hombre y en el raton. Esto ha permitido la union de vpr20 con db neutralizantes de vih-1, para la construccion de inmunogenos capaces de inducir una respuesta proliferativa y de anticuerpos neutralizantes. La polimerizacion de tales inmunogenos ha llevado en algunos casos a un aumento de la respuesta frente a los determinantes, mientras que en otros ha creado estructuras diferentes al peptido original.
A plant to plate pilot: a cold‐climate high school garden increased vegetable selection but also waste (2015)

This preliminary investigation suggests that school gardens increased selection and intake of school-raised produce. Although a third was not eaten, it is promising to see that still more produce was consumed compared to the past.
Isolation of natural arachidonic acid as its methyl ester (1951)

Summary Fresh beef suprarenal glands were ground and extracted thoroughly with alcohol and then with ethyl ether. After removal of solvent the total lipid residue was saponified, and the fatty acids were recovered by extraction. The less unsaturated acids were removed by crystallization from acetone at −40°C. At this stage the filtrate contained essentially all the arachidonic acid originally present in the glands and also unsaponifiable matter. After the unsaponifiable material was removed, the arachidonic acid content of the concentrate was about 25%. These unsaturated acids were converted to their methyl esters and fractionated on a silicic acid adsorption column. The progress of the adsorption fractionation was followed by spectrophotometric examination and determination of iodine values of the eluted fractions. Methyl arachidonate of 90% purity was obtained by this means. It was further purified by fractional distillation in vacuo. The final product had an iodine value of 316.1; theory, 318.8. The purity of this preparation was further established by spectrophotometric examination, by saponification equivalents, mean molecular weight, and by x‐ray diffraction patterns and melting points of a completely hydrogenated portion. Evidence of acids of greater unsaturation than arachidonic acid in suprarenal lipids was also clearly established by spectrophotometric examination. A fraction was obtained which was estimated to contain about 80–85% of a C 20 acid with five double bonds.
Computer Aided Measuring of Textile-Mechanical Parameters (2008)

A new equipment for measuring the draping characteristics of static cloth is presented in the paper. In contrast with Kawabata Evaluation System 3D geometrical data of the sample are captured from photo images. Based on a mathematical reconstruction of geometry, and drape coefficients and mechanical parameters are evaluated upon the geometrical model. The computer controlled equipment moves a round table positioned in the centre providing the natural pleating of fabric for the measuring. The core part of the equipment is a computer moved frame. The sample is scanned by laser-beams. Lasers light the cross section curves of the sample on different levels. There are four cameras on the frame taking the pictures of cross section curves in different levels. 3D geometry is reconstructed upon the pictures. A mass, spring and damping element system is the basis of the cloth simulator. Springs are assumed to be linear, while damps are proportional to the velocity. The physics engine running the simulator calculates vertex positions at a time based on interaction forces with neighbouring vertices, including stretch, bend and shear forces. Collision of the cloth model with the model of the underlying object is performed and handled in each time step. To evaluate the influence of the individual parameters, a series of simulations was performed. For the real cloth samples, a range of cross-section curves is captured, digitalized and interpolated by Fourier series. The same Fourier coefficients are determined for the cloth model as a function of simulation parameters. The actual simulation parameters are defined by the minimum of the difference between the modelled and the measured geometry.
A New and Expedient Total Synthesis of Ochratoxin A and d5-Ochratoxin A (2009)

A new total synthesis of the mycotoxin ochratoxin A (OTA) is presented, in which it is prepared in 9% overall yield from commercially available substrates. The key step consists of the condensation reaction between protected l-phenylalanine and 5-chloro­-8-hydroxy-3-methyl-1-oxoisochromane-7-carboxylic acid (ochratoxin α, OTα). The same strategy could be successfully applied to l-d 5-phenylalanine, leading to the first total synthesis of d 5-OTA, a molecular tracer for the detection and analytical quantification of the natural mycotoxin in food samples by means of stable isotope dilution assay (SIDA).
Nitrifying biotower upsets due to snails and their control (1997)

The primary purpose of this study was to find the proper operating parameters for successful operation of the nitrification biotowers at the North Regional Wastewater Treatment Plant in Dayton, Ohio, and to recommend an operational protocol to prevent future failures. This plant is subject to regular, periodic biotower upsets. It was found that these upsets are correlated with blooms of snails (Physa gyrina) which it is believed graze the biofilm and devour the nitrifying organisms. Snail control mechanisms are under investigation.
Repeated Dry-Contact Ultrasonic Imaging of an Electronic Package through an Elastomer Membrane (2004)

Dry-contact ultrasonic technique, which realizes the ultrasonic imaging without getting a sample wet, is a useful method for the inspection of electronic packages. In this study, we transmit high frequency ultrasound into the acrylic resin targets via four kinds of elastomer membranes with stability, and high durability, and select a membrane for cyclic ultrasonic imaging under a dry-contact condition. For recording high quality acoustic images, the membrane must satisfy the low ultrasonic attenuation and high acoustic coupling at the membrane/sample interface. Finally, we perform the cyclic ultrasonic imaging of an electronic package via the selected membrane, and repeatedly visualize the delamination in the package.
Exploring the Business Object Collection Pattern (2003)

In the previous chapter, you learned about a generic pattern for representing business objects. The pattern assumed that the business object was a standalone object. This scenario is not realistic in business applications. Collections of business objects are far more common than stand-alone business objects. In fact, it is challenging to think of a simple business object that has value in a business application. Nonetheless, Chapter 6, "Exploring the Business Object Pattern" provided you with both a learning experience and a solid foundation for the Business Object Collection pattern.KeywordsBusiness ObjectPrevious ChapterBusiness ApplicationSimple Access Object ProtocolService ImplementationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Pitchfork beam shaping for laser micorvia drilling (2008)

Laser beam shaping allows redistribution of laser power and phase across the cross-section of the beam for drilling perfectly cylindrical holes. The main purpose of this paper is to show that pitchfork beams improve the microvia quality significantly. An optical system, which comprises three lenses, is designed using conventional diffraction analysis and ray tracing technique to transform a Gaussian beam into a pitchfork beam. The first two lenses are the phase elements through which a Gaussian laser beam is transformed into a super Gaussian beam. The ray tracing technique of geometrical optics is used to design these phase elements. The third lens is the transform element which produces a pitchfork profile at the focal plane due to the diffraction effect. Another aspect of this paper is to demonstrate a pinhole scanning power meter to measure the laser beam profile at the focal plane where the irradiance is very high. This measurement technique is used to verify the existence of the pitchfork beam at the high irradiance plane. © 2008 IOP Publishing Ltd.
Optical metrology of multilayer mirrors for attosecond light pulse (2010)

poster
Terahertz Spectroscopy for Measuring Multiphase Fractions (2017)

In this paper, an experimental study was conducted using terahertz (THz) spectroscopy to assess the electromagnetic properties in the THz range of various materials that can be found in oil and gas fields. This includes the absorbance, transmittance, and refraction properties of crude oil (i.e., PS65 oil in this paper), water, solid contaminants, and various mixtures of these contents. The first set of experiments was conducted to assess the effects of temperature on THz absorbance. This revealed that the temperature does not have a substantial effect on the absorbance coefficient. On the other hand, other experiments indicated that the absorbance coefficient is much higher for solid contaminants particles than for either crude oil or water. In addition, when solid contaminants are mixed with the crude oil, the absorbance coefficient varies with respect to the way the solid contaminants are distributed within the sample and increase proportionally to the amount of solid contaminants. In case of crude oil-water mixture, it is found that the absorbance coefficient increases as the water content increases. However, compared to solid contaminants, its absorbance value is much lower. The results obtained for THz spectrums and the corresponding principal component analysis graphs demonstrate the potential that THz-based devices would have in effectively measuring concentrations of solid and liquid multiphase flows, including solid contaminants which can hinder the quality of oil and gas flowing through the pipe. It would also help to monitor the quality of exported oil, which usually still contains water phase, in spite of series of oil-water separation process.
Architecture and circuit techniques for a 1.1-GHz 16-kb reconfigurable memory in 0.18-/spl mu/m CMOS (2005)

This paper presents the architecture and circuit techniques for a reconfigurable SRAM building block. The memory block can emulate many memory structures including a cache tag or data array, a FIFO, and a simple scratchpad memory. We choose the block size based on the optimal partition size for large SRAM structures, use self-resetting and replica timing circuit techniques, and add flexible status bits and a few hardwired functional blocks to support reconfigurability. A 16-kb prototype design fabricated in a 0.18 /spl mu/m technology cycles at 1.1 GHz at the nominal 1.8 V supply and room temperature. The additional logic used for reconfigurability consumes 32 % of the area and 23 % of the power of the memory block. We project that these overhead percentages would fall below 15% and 10%, respectively, for a 64-kb memory.
Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer (2004)

This study shows that EGFR and MDM2 play a critical role in the growth of prostate cancer, especially hormone-dependent, and that their combined blockade by gefitinib and AS-MDM2 causes a cooperative antitumor effect, supporting the clinical development of this therapeutic strategy.
Search for supersymmetry in events with a photon, a lepton, and missing transverse momentum in pp collisions at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>8</mml:mn><mml:mtext> TeV</mml:mtext></mml:math> (2016)

A search for supersymmetry involving events with at least one photon, one electron or muon, and large missing transverse momentum has been performed by the CMS experiment. The data sample corresponds to an integrated luminosity of 19.7 fb -1 of pp collisions at s = 8 TeV, produced at the CERN LHC. No excess of events is observed beyond expectations from standard model processes. The result of the search is interpreted in the context of a general model of gauge-mediated supersymmetry breaking, where the charged and neutral winos are the next-to-lightest supersymmetric particles. Within this model, winos with a mass up to 360 GeV are excluded at the 95% confidence level. Two simplified models inspired by gauge-mediated supersymmetry breaking are also examined, and used to derive upper limits on the production cross sections of specific supersymmetric processes.
Enhancing Cancer Drug Discovery through Novel Cell Signaling Pathway Panel Strategy (2013)

The link between signaling pathways and diseases suggests the importance of pathway analysis for drug discovery. This includes target identification and validation, compound mode of action and drug candidate optimization. Here, we propose to apply cell signaling pathway panel approaches for oncology drug discovery. The strategies and guiding principles of the pathway panel approach are discussed. 2 pathway analysis examples with related processes and technology platforms are illustrated to identify cancer drugs that target cancer growth and metastasis. Finally, we highlight potential challenges and opportunities presented by the pathway panel approach.