gebhart/patrepeval huggingface dataset:
Abstract A78: MUC1 drives c-Met-dependent migration and scattering (2013)

Abstract The transmembrane mucin MUC1 is overexpressed in most ductal carcinomas, and its overexpression is frequently associated with metastatic progression. MUC1 can drive tumor initiation and progression via interactions with many oncogenic partners, including β-catenin, the epidermal growth factor receptor (EGFR) and Src. The decoy peptide PMIP (Protein transduction domain MUC1 Inhibitory Peptide) has been shown to inhibit the tumor promoting activities of MUC1 in breast and lung cancer, including cell growth and invasion, and its usage suppresses metastatic progression in mouse models of breast cancer. To further characterize the reduced metastasis observed upon PMIP treatment, we performed motility assays and observed that PMIP inhibits cell motility of breast cancer cells. To determine the mechanism by which PMIP inhibits motility, we evaluated changes in global gene transcription upon PMIP treatment, and identified a number of genes with altered expression in response to PMIP. Among these genes is the metastatic mediator, c-Met, a transmembrane tyrosine kinase that can promote cell scattering, migration and invasion. To further investigate the role of c-Met in MUC1-dependent metastatic events, we evaluated the effects of MUC1 expression and EGFR activation on breast cancer cell scattering, branching and migration. We found that MUC1 strongly promoted all of these events and this effect was further amplified by EGF treatment. Importantly, the effect of MUC1 and EGF on these phenotypes was dependent upon c-Met activity. Overall, these results indicate that PMIP can block the expression of a key metastatic mediator, further advancing its potential use as a clinical therapeutic. Citation Format: Teresa M. Horm, Benjamin G. Bitler, Derrick M. Broka, Jeanne Louderbough, Joyce A. Schroeder. MUC1 drives c-Met-dependent migration and scattering. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A78.
Damper windings in induction machines for reduction of unbalanced magnetic pull and bearing wear (2011)

In large induction machines (such as cage large induction motor pumps in the petro-chemical industry and cage or wound-rotor induction generators in wind turbines) reliability and longevity is advantageous. This is particularly relevant to wind turbine generators which can be inaccessible. There will be some degree of tolerance and wear that will lead to low-level rotor eccentricity. For a p <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> -pole pair machine there will be p <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> ±1 pole pair flux waves set up by the eccentricity which will generate unbalanced magnetic pull (UMP), as well as additional higher space harmonics. This paper addresses the use of stator damper windings to reduce the side-band flux waves and hence attenuate the UMP. Examples are put forward in terms of a 10 pole cage-rotor machine with static or dynamic rotor eccentricity and then extended to use a 4 pole machine wound-rotor machine. A tested analytical model is developed to include these damper windings and the wound rotor; they are shown to reduce the UMP, particularly in a wound-rotor machine. The simulations here are in terms of a wound-rotor machine but this can be extended for DFIG operation.
Expression of hematopoietic growth factor receptors on early hematopoietic precursors: detection and regulation (2000)

Since the original isolation of colony-stimulating factors from human serum, conditioned medium of murine or human cell lines, or freshly isolated human mononuclear cells, a revolutionary explosion of ideas has occurred in our understanding of molecular controls of the hematopoietic stem cell self-renewal and differentiation. With the availability of techniques of molecular cloning in the early 1 980s, the first hematopoietically activated cytokines led to molecular clones expressed in bacteria, yeast, or mammalian cellular systems. There then followed a development of techniques leading to the molecular cloning and expression of many hematopoietic growth factors and their receptors, as well as the primary, secondary, and tertiary molecules in signal transduction into activation of specific genes for differentiation or self-renewal. The clinical use of these factors in the diagnosis, treatment, and incorporation into new cell therapies for a variety of diseases is a subject of current interest.
Ion speciation driving chirality transfer in imidazolium-based camphorsulfonate ionic liquid solutions (2011)

The underlying principle of the chirality transfer in imidazolium-based camphorsulfonate ionic liquids is rationalized by linking catalytic results from the hydrogenation of [N-(3'-oxobutyl)-N-methylimidazolium] [(+)-camphorsulfonate] to [N-(3'-hydroxybutyl)-N-methylimidazolium] [(+)-camphorsulfonate] in tetrahydrofuran with electrolyte theory by the help of dielectric relaxation spectroscopy. Using this approach we are able to explain why the maximum of the enantiomeric excess of the hydrogenation reaction in tetrahydrofuran is found at a medium concentration of 0.15 mol L(-1), whereas it declines at both, lower and higher concentrations. Dielectric spectra in the concentration range between 0.05 and 1.0 mol L(-1) reveal a solute mode due to dipolar ion pairs and larger dipolar ion clusters. They verify that at very low concentrations the ionic liquid ions are fully solvated with an increasing tendency to form neutral ion pairs with increasing concentration. Already at 0.025 mol L(-1) the degree of dissociation reaches a minimum reflecting a maximum of neutral ion pair formation. With increasing ionic liquid concentration ordered ion clusters are formed by two and more ion pairs. At high concentrations these clusters collapse by dilution in the excess ionic liquid and the defined ion contact necessary for the chirality transfer is lost to a great extent.
The /spl lambda/-scheduler: A multiwavelength scheduling switch (2000)

We propose a new multiwavelength almost all-optical switch architecture called the /spl lambda/-scheduler that uses wavelength division multiplexing (WDM) internally to fold the switch architecture in both the space and time domains to reduce the hardware complexity and to improve the signal characteristics through the switch. The /spl lambda/-scheduler preserves the packet order for a given input-output pair, is consistent with virtual circuit switching, and when combined with appropriate connection and flow control protocols, provides lossless communication for bursty (or nonconstant rate) traffic, provided the traffic satisfies certain smoothness properties. The /spl lambda/-scheduler uses novel scheduling and wavelength assignment algorithms, in conjunction with a series of feed-forward delay blocks, to avoid packet collisions within the switch or at the switch outputs. We present two implementations of the /spl lambda/-scheduler when the number of internal wavelengths k equal the number of inputs (and outputs) N to the switch. In the compressed /spl lambda/-scheduler, the N internal wavelengths are used to fold the architecture in the time domain, which reduces the total number of delay blocks for the switch by 2N log N. In the collapsed /spl lambda/-scheduler, the N internal wavelengths are used to fold the architecture in the space domain, which reduces the number of delay blocks and total fiber length used for delays by a factor of N. We examine the insertion loss for both /spl lambda/-scheduler implementations and discuss the trade-offs between the reduction in overall component count and the improvement in the signal characteristics.
Designing malaria vaccines to circumvent antigen variability (2015)

Prospects for malaria eradication will be greatly enhanced by an effective vaccine, but parasite genetic diversity poses a major impediment to malaria vaccine efficacy. In recent pre-clinical and field trials, vaccines based on polymorphic Plasmodium falciparum antigens have shown efficacy only against homologous strains, raising the specter of allele-specific immunity such as that which plagues vaccines against influenza and HIV. The most advanced malaria vaccine, RTS,S, targets relatively conserved epitopes on the P. falciparum circumsporozoite protein. After more than 40 years of development and testing, RTS,S, has shown significant but modest efficacy against clinical malaria in phase 2 and 3 trials. Ongoing phase 2 studies of an irradiated sporozoite vaccine will ascertain whether the full protection against homologous experimental malaria challenge conferred by high doses of a whole organism vaccine can provide protection against diverse strains in the field. Here we review and evaluate approaches being taken to design broadly cross-protective malaria vaccines.
The nucleation sites of micropipes in SiC (2017)

Micropipes are hollow-core dislocations aligned along the growth direction of sublimation grown SiC ingots. We found micropipes nucleated in the interface region between the seed crystal and the grown ingot adjacent to stacking fault clusters on tilted closed packed planes. A relation between the edge and the screw component of the dislocation in the micropipe is derived.
434. Studies with furans. Part I. The synthesis of furans having a β-methylcrotonoyl side-chain (1962)

P. A. Finan and G. A. Fothergill, J. Chem. Soc., 1962, 2262 DOI: 10.1039/JR9620002262
Automatic Assessment of Depression from Speech and Behavioural Signals (2014)

Research into automatic recognition and prediction of depression from behavioural signals like speech and facial video represents an exciting mix of opportunity and challenge. The opportunity comes from the huge prevalence of depression worldwide and the fact that clinicians already explicitly or implicitly account for observable behaviour in their assessments. The challenge comes from the multi-factorial nature of depression, and the complexity of behavioural signals, which convey several other important types of information as well as depression. Investigations in our group to date have revealed some interesting perspectives on how to deal with confounding effects (e.g. due to speaker identity) and the role of depression-related signal variability. This presentation will focus on how depression is manifested in the speech signal, how to model depression in speech, methods for mitigating unwanted variability in speech, how depression assessment is different from more mainstream affective computing, what is needed from depression databases, and different possible system designs and applications. A range of fertile areas for future research will be suggested.
Polyacrylamide Gel Disc Electrophoresis of Alkaline Proteinases from<i>Aspergillus</i>Species (1971)

Journal Article Polyacrylamide Gel Disc Electrophoresis of Alkaline Proteinases from Aspergillus Species Get access Seiichi Nasuno Seiichi Nasuno Noda Institute for Scientific Research Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 35, Issue 7, 1 July 1971, Pages 1147–1150, https://doi.org/10.1080/00021369.1971.10860048 Published: 01 July 1971 Article history Received: 20 April 1971 Published: 01 July 1971
Magnetic Field Sensing by Exploiting Giant Nonstrain-Mediated Magnetodielectric Response in Epitaxial Composites (2018)

Heteroepitaxial magnetoelectric (ME) composites are promising for the development of a new generation of multifunctional devices, such as sensors, tunable electronics, and energy harvesters. However, challenge remains in realizing practical epitaxial composite materials, mainly due to the interfacial lattice misfit strain between magnetostrictive and piezoelectric phases and strong substrate clamping that reduces the strain-mediated ME coupling. Here, we demonstrate a nonstrain-mediated ME coupling in PbZr<sub>0.52</sub>Ti<sub>0.48</sub>O<sub>3</sub> (PZT)/La<sub>0.67</sub>Sr<sub>0.33</sub>MnO<sub>3</sub> (LSMO) heteroepitaxial composites that resolves these challenges, thereby, providing a giant magnetodielectric (MD) response of ∼27% at 310 K. The factors driving the magnitude of the MD response were found to be the magnetoresistance-coupled dielectric dispersion and piezoelectric strain-mediated modulation of magnetic moment. Building upon this giant MD response, we demonstrate a magnetic field sensor architecture exhibiting a high sensitivity of 54.7 pF/T and desirable linearity with respect to the applied external magnetic field. The demonstrated technique provides a new mechanism for detecting magnetic fields based upon the MD effect.
Oxalylation of N‐Phenylanthranilic‐O‐alkylhydroxamates to 4‐Alkoxy‐2,3,4,5‐tetrahydro‐1H‐1,4‐benzodiazepine‐2,3,5‐triones. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Compact Fuel Cell Power Supplies with Safe Fuel Storage (2004)

A statistical analysis of the Protein Databank (PDB) structures had led us to define a set of small 3D structural prototypes called Protein Blocks (PBs). This structural alphabet includes 16 PBs, each one defined by the (phi, psi) dihedral angles of 5 consecutive residues. Here, we analyze the effect of the enlargement of the PDB on the PBs' definition. The results highlight the quality of the 3D approximation ensured by the PBs. These last could be of great interest in ab initio modeling.
The Determination of Sizing Agent on Sized Nylon Yarns (1958)

研究目的現在のナイロンノリ付用のP.V.A.はほとんどゴーセノールGL-05が使用されている。しかしナイロンノリ付糸のノリ定量に関しては, 重量法が一般に行われている, 重量法で行うと, ナイロンの水溶性成分 (主としてモノマ) が溶出して誤差の原因となり, 正確な定量ができない.デンプンや, P.V.A.にヨ-ドを添加すると赤色または赤紫色に呈色することは衆知の事実である, この呈色を利用すれば, ノリ付糸のノリ定量を比色法で行うことができるはずである。この比色法を用いて従来の重量法と比較検討した.研究結果この比色法を用いると, いままでの重量法で誤差の原因となっていたナイロン糸の水溶性成分の影響を全然うけないので, かなり正確な結果を出すことができる。比色定量法が可能と思われる点をあげると, 次のとおりである。1.P.V.A.とヨードとの呈色溶液の最大吸收波長は500mμ でP.V.A.濃度が変化しても最大吸收波長はかわらない.2.P.V.A.濃度と吸光度の関係は直線関係が成立してLambert-Beerの法則にしたがうことがわかった.3.ホウ酸添加量が増加しても最大吸收波長はかわらない.4.放置時間における呈色強度は時間がたつにつれていくぶん不安定になるが, 10min以内に測定すれば定量は十分可能と考えられる。5.油剤が吸光度におよぼす影響はほとんどみとめられない.
Improvement of Plant Establishment in Bell Pepper with a Gel Mix Planting Medium (1988)

Abstract Germinated pepper ( Capsicum annuum L.) seeds were combined with plug-mix, or plug-mix and Liquagel or Laponite 445 gel at various concentrations and volumes of solution to determine their effects on plant stands and seedling growth. Treatments with pregerminated seed led to earlier, more uniform seedling emergence and larger seedlings than those with non-pregerminated seeds. Final plant stands were similar for both treatments. Plant stands and seedling growth were greater and more uniform with Liqua-gel gel mix formulations than Laponite. Seeds in planting mixes with high concentrations of Laponite (2.0% by volume) and large volumes of gel solution (1.75 liter per liter of plug-mix) in dry and moist soils emerged slower and resulted in lower and less uniform stands than the plug-mix treatments. The optimum gel mix medium for plant establishment (rate and total emergence, stand uniformity, and early seedling growth) consisted of 1.0 liter of plug-mix per 1.25 liters of gel solution at a Liqua-gel concentration of 1.0%.
LABORATORY COMPARISON OF AEDES AEGYPTI ATTRACTION TO HUMAN ODORS AND TO SYNTHETIC HUMAN ODOR COMPOUNDS AND BLENDS<sup>1</sup> (2007)

Chemical lures can enhance the ability of traps to collect mosquitoes, selectively target species for capture, and provide a realistic assessment of the species and host-equivalent numbers of mosquitoes present in the local area. One approach to the development of chemical lures is to manufacture blends that comprise odors released in human emanations. These blends need to be safe for use in the environment, desirable from an economic standpoint, and transportable to the field for use in traps. In this report, we compared the attraction of mosquitoes to various chemicals, blends, and odors from humans. Noncompetitive (single-treatment) bioassays established that some blends are equivalent or more attractive to Aedes aegypti than human odors. Competitive bioassays were conducted; these involved simultaneous comparison of 2 treatments: single compounds to binary blends; binary blends to a trinary blend of L-lactic acid, acetone, and dimethyl disulfide; and the trinary blend to human odors from 3 volunteers. The overall trend was that the trinary blend was more attractive than binary blends, and binary blends were more attractive than single compounds. However, human odors were still significantly more attractive than the trinary blend. Therefore, further modifications and refinements to blends will be needed to better compete against human odors.
Distributed process monitoring and control using FPGA (2014)

This paper presents a system to implement a process monitoring and control system on FPGA in order to replace PLC's from any industrial environment. The system implemented contains slave nodes being monitored and controlled through a single master node connected to a PC. This enables the centralized control of any industrial environment with plants distributed on considerable distances. The master FPGA is implemented in order to reduce the load from the PC as it collects the data from all the slaves over a wireless link. Wireless links provide possibility of long distance control. It can be a simple RF transceivers or a GSM modem. The slave FPGA collects data from different sensors and processes them in order to calculate the desired actuator response to control the respective parameters. These limits, with in which the parameters are to be limited, are sent on the wireless link from the master to individual Slave and gets updated using the GUI on the PC. The advantage of using FPGA is that they can be programmed in system without the need of detaching it from the system. This feature gives an advantage over a PLC which requires disconnection from the system when the internal programming needs to be changed. The only disadvantage was that the separate power switching circuits were designed for power switching. It is observed that the control and monitoring was possible in real time due to high data rate and the values were controlled well within the limits defined by the user.
Electrostatic focusing accelerator consisting of multiple coaxial cylinders (2001)

An electrostatic accelerating and focussing system for electron with energies up to 150 keV is presented in this paper. The energy and angular resolution reached by this system give the ability to realize spectrometric studies of scattered electrons by molecular target in condensed phase. At 150 keV, the calculation of the electron trajectories, the aberration treatment and the optimization of the system have been performed by means of a relativistic matrix method.
New Real-Time PCR Assay Using Locked Nucleic Acid Probes To Assess Prevalence of ParC Mutations in Fluoroquinolone-Susceptible <i>Streptococcus pneumoniae</i> Isolates from France (2006)

A real-time PCR assay with locked nucleic acid probes was developed to screen mutations at codons 79 and 83 of the Streptococcus pneumoniae parC gene. Only silent mutations were detected among 236 French invasive fluoroquinolone-susceptible strains. This test could be useful for some high-risk patients or in national surveys.
Extraction of Thematic Roles from Dictionary Definitions (1996)

Our research goal has been the development of a domain independent natural language processing (NLP) system suitable for information retrieval. As part of that research, we have investigated ways to automatically extend the semantics of a lexicon derived from machine-readable lexical sources. This paper details the extraction of thematic roles derived from lexical patterns in a machine-readable dictionary.
Momordica Charantia (Bitter Melon) Inhibits Primary Human Adipocyte Differentiation by Modulating Adipogenic genes (2010)

Momordica charantia or bitter melon (BM) that is traditionally used to treat diabetes and complications has been demonstrated to alleviate hyperglycemia as well as reduce adiposity in rodents. The objective of our study was to investigate the effects of BM juice (BMJ) on lipid accumulation and adipocyte differentiation factors in primary human preadipocytes and differentiated adipocytes. Preadipocytes treated with varying concentrations of BMJ during differentiation significantly reduced lipid accumulation as well as the mRNA expression of peroxisome proliferator‐associated receptor (PPAR), sterol regulatory element‐binding protein 1c (SREBP‐1c) and resistin genes. Similarly, differentiated adipocytes treated with BMJ for 48 h demonstrated reduced lipid accumulation, perilipin mRNA expression, and increased lipolysis. Our data suggests that BM is a potent inhibitor of lipogenesis and stimulator of lipolysis activity in primary human adipocytes. BMJ may therefore prove to be an effective complementary or alternative therapy to induce anti‐obesity effects in humans. [Grants: NCCAM (R21AT003719), RCMI, NCRR (G12RRAI03061), NIH, and Hawaii Community Foundation (20041652)].
The pragmatic web (2002)

People use the Web to share information. For machines to exploit information on theWeb, however, presupposes well-structured, meaningful markups, which is what the WorldWide Web Consortium's Semantic Web activities seek to develop (www.w3.org/2001/sw/). Currentapproaches are limited, however. They provide meaning only to the extent that it can be capturedstatically. I claim that successful approaches to creating the Semantic Web lie within the scope ofpragmatics.
Requirements on flexible robot systems for small parts assembly: A case study (2011)

Today's small parts assembly lines are typically fully manual or fully automated. When human workers and robots, or other mechanical equipment, work together in a hybrid line concept, there is always a sacrifice of flexibility and a high engineering cost, caused by safety and ergonomic requirements. This paper will outline a study performed with the purpose of investigating the requirements posed on industrial robots introduced into otherwise manual assembly lines, while lifting such limitations. Moreover, it presents some results from a research effort where a robot has been developed that meets these requirements, including a discussion on how this robot could be used in future assembly systems that allow for a partial and scalable automation component.
Recent advances with π-conjugated salen systems (2011)

Schiff base ligands have long been successfully employed as ligands in combination with various metals to give catalysts capable of realizing a variety of synthetic transformations. One of the most widely used Schiff base ligands, the "salen" ligand, has been extensively researched. Recently, there has been increased interest in π-conjugated salen systems, known as "salphen" ligands, as a result of the differences in reactivity of the complexes in catalytic applications compared with the salen analogues. Complexes of salphen ligands display interesting photophysical and supramolecular properties which are not always observed with salen systems as a result of their π-conjugation. This tutorial review therefore describes the most significant advances recently made with salphen and related π-conjugated ligand systems.
Leak Localization in Water Distribution Networks using Fisher Discriminant Analysis (2018)

This paper addresses the problem of leak localization in water distribution networks (WDN) using Fisher Discriminant Analysis (FDA). First, the paper introduces how FDA can be used for leak localization using the information of pressure measurements from the sensors available in the WDN. Then, the problem of sensor placement is considered when the proposed leak localization based on FDA is used. The proposed leak localization and sensor placement approaches based on FDA will be used using a well-known WDN case study.