gebhart/patrepeval huggingface dataset:
Geometric Isomers of Substituted Triphenylethylenes and Antiestrogen Action (1981)

The estrogenic and antiestrogenic activities of tamoxifen ICI 47,699, enclomiphene, zuclomiphene, and the geometric isomers of monohydroxytamoxifen and CI628 were determined in the 3-day immature rat uterine weight test. Tamoxifen, enclomiphene, and the releated geometric isomers of monohydroxytamoxifen and CI628 were partially estrogenic with antiestrogenic properties. ICI 47,699 and zuclomiphene were predominantly estrogenic; however, an antiestrogen effect for zuclomiphene (100 μg daily) was demonstrable and large doses of ICI 47,699 (1 or 10 mg daily) inhibited full estrogen action. In contrast, the geometric isomers of monohydroxytamoxifen and CI628 related to ICI 47,699 and zuclomiphene were partiallyestrogenic with antiestrogenic properties. The estrogenic properties of ICI 47,699 were classified in three ways: elevation of uterine wet weight, increase in whole uterine DNA, and increase in the mitotic activity of luminal epithelial cells. In general, ICI 47,699 was able to initiate estrogenic responses of DNA synthesis or mitosis by translocation of fewer cytoplasmic estrogen receptors to the nuclear compartment than tamoxifen. A model is proposed to explain antiestrogen action in terms of the geometric requirements for receptor binding. It is suggested that the position in space of the alkylaminoethoxyside chain is of fundamental importance. Overall, these data lend support to the view that a structurally specific ligand-estrogen receptor complex can influence the future events within a target tissue to produce either an agonist or an antagonist response.
Fall Bulletin 2000 (2000)

TABLE OF CONTENTS From the Director (Thak Chaloemtiarana) - 1 • George T. McKahin - Benedict Anderson - 2 • Kahin Memorial Celebration - 4 • Professor George Kahin's Graduate Students - 5 • Benedict Anderson Selected as Asian Cultural Prize Laureate - 9 • Staging Gender in Thailand: Fieldwork as Drag - Thamora Fishel - 10 • Globalization, Workers, and Industrial Relations Institutions in Southeast Asia Sarosh Kuruvilla - 13 • Wind, Water, and Fire: Sketches of Balinese Soundscapes - Arsenio Nicholas- 17 • Silent Song in the South Pacific - 18 • SEAP 2000 Event Highlights - 19 • O'Connor Festschrift - 20 • Southeast Asia Program Publications - 22 • SEAP Students' Accomplishments - 23 • SEAP Outreach - 24 • SEAP Courses 2000-2001 - 25 • SEAP Faculty - 29
Aspirin and lung cancer risk in a cohort study of women: dosage, duration and latency (2007)

Aspirin may reduce the risk of cancer at some sites but its effect at the lung is unclear. We prospectively examined associations between aspirin use and risk of lung cancer in 109,348 women in the Nurses' Health study from 1980 to 2004. During this time, 1,360 lung cancers were documented in participants 36-82 years of age. Aspirin use and smoking were assessed every 2 years. Risk of lung cancer was a non-significant 16% lower for regular aspirin users of one or two tablets per week and a significant 55% higher for users of 15 or more tablets per week compared with women who never regularly used aspirin. Results were similar when limited to never smokers. For both the low and high quantity aspirin users, risk of lung cancer did not decline or increase with longer durations of use, and associations attenuated as the latency period between aspirin assessment and lung cancer diagnosis was lengthened. Our findings, together with those from previous clinical trials and prospective studies, do not provide consistent evidence that aspirin influences the development of lung cancer and further investigation is required with adjustment for smoking.
Modeling Dyadic Interactions and Networks in Marketing (1992)

Many substantive areas in marketing share a basic concern with relationships. Social network and dyadic interaction methods are techniques that can enrich a researcher's understanding of the structure of relationships, whether a few actors or many are involved and whether the relationships are at the consumer or business level. Network models are discussed in a variety of substantive areas, including coalition formation in buying centers, identification of opinion leaders in word-of-mouth networks, power and cooperation in channel dyads, conflict resolution in family purchasing, and the management of expectations in service encounters. In addition, important modeling advances are described, including techniques that enable researchers to make comparisons between networks and adaptations of reciprocity parameters to allow for identification of stochastic cliques.
<i>C</i>-Glycosylflavones Alleviate Tau Phosphorylation and Amyloid Neurotoxicity through GSK3β Inhibition (2016)

Alzheimer's disease (AD) is the most common brain disorder worldwide. Aberrant tau hyperphosphorylation and accumulation play critical roles in the formation of neurofibrillary tangles highly associated with neuronal dysfunction and cognitive impairment in AD pathogenesis. Glycogen synthase kinase-3β (GSK3β) is a key kinase responsible for tau hyperphosphorylation. Selective inhibition of GSK3β is a promising strategy in AD therapy. Corn silks (CS, Zea mays L.) have been traditionally used as a medicinal herb and recently noted for their potentially cognitive benefits. However, the neuroprotective components of CS and their molecular mechanism have received little attention to date. As part of our effort screening phytochemicals against a broad panel of kinases targeting AD tauopathy, we found inhibition of GSK3β by CS extracts. Subsequent bioassay-guided fractionation led to the isolation and identification of two 6-C-glycosylflavones, isoorientin (1) and 3'-methoxymaysin (2), with selective inhibition against GSK3β in vitro. Enzyme kinetics and molecular docking studies demonstrated that 1 specifically inhibited GSK3β via an ATP noncompetitive mechanism, acting as a substrate competitive inhibitor of GSK3β. Further in vitro cellular studies demonstrated that 1 effectively attenuated tau phosphorylation mediated by GSK3β and was neuroprotective against β-amyloid-induced tau hyperphosphorylation and neurotoxicity in SH-SY5Y cells. The C-glycosylflavones represent new lead candidates with a novel mechanism of action for the development of AD phytopharmaceuticals.
Dances with words (2007)

Animated text is an appealing field of creative graphical design. Manually designed text animation is largely employed in advertising, movie titles and web pages. In this paper we propose to link, through state of the art NLP techniques, the affective content detection of a piece of text to the animation of the words in the text itself. This methodology allows us to automatically generate affective text animation and opens some new perspectives for advertising, internet applications and intelligent interfaces.
A low power CMOS 3.3 Gbps continuous-time adaptive equalizer for serial link (2011)

This paper describes using a high-speed continuous-time analog adaptive equalizer as the front-end of a receiver for a high-speed serial interface, which is compliant with many serial communication specifications such as USB2.0, PCI-E2.0 and Rapid IO. The low and high frequency loops are merged to decrease the effect of delay between the two paths, in addition, the infinite input impedance facilitates the cascade stages in order to improve the high frequency boosting gain. The implemented circuit architecture could facilitate the wide frequency range from 1 to 3.3 Gbps with different length FR4-PCB traces, which brings as much as 25 dB loss. The replica control circuits are injected to provide a convenient way to regulate common-mode voltage for full differential operation. In addition, AC coupling is adopted to suppress the common input from the forward stage. A prototype chip was fabricated in 0.18-μm 1P6M mixed-signal CMOS technology. The actual area is 0.6 × 0.57 mm2 and the analog equalizer operates up to 3.3 Gbps over FR4-PCB trace with 25 dB loss. The overall power dissipation is approximately 23.4 mW.
Automatic Feature Extraction for Multiview 3D Face Recognition (2006)

Current 2D face recognition systems encounter difficulties in recognizing faces with large pose variations. Utilizing the pose-invariant features of 3D face data has the potential to handle multiview face matching. A feature extractor based on the directional maximum is proposed to estimate the nose tip location and the pose angle simultaneously. A nose profile model represented by subspaces is used to select the best candidates for the nose tip. Assisted by a statistical feature location model, a multimodal scheme is presented to extract eye and mouth corners. Using the automatic feature extractor, a fully automatic 3D face recognition system is developed. The system is evaluated on two databases, the MSU database (300 multiview test scans from 100 subjects) and the UND database (953 near frontal scans from 277 subjects). The automatic system provides recognition accuracy that is comparable to the accuracy of a system with manually labeled feature points.
The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER‐2/neu transgenic mice (2002)

The effect of various regimens of treatment with melatonin on the development of mammary tumors in HER2/neu transgenic mice was investigated. Female HER-2/neu mice starting from the age of 2 months were kept under standard light/dark regimen and as given melatonin with tap water (20 mg/l) during the night time 5 times monthly (interrupted treatments) or constantly to natural death. Intact mice served as controls. Treatment with melatonin slowed down age-related disturbances in estrous function most in the group exposed to interrupted treatment with the hormone. Constant treatment with melatonin decreased incidence and size of mammary adenocarcinomas, and incidence of lung metastases, compared to controls. The number of mice bearing 4 and more tumors was reduced in the group with constant melatonin treatment. Interrupted treatment with melatonin promote mammary carcinogenesis in HER-2/neu transgenic mice. The data demonstrate the regimen-dependent inhibitory effect of melatonin on the development of spontaneous mammary tumors in HER-2/neu mice but not on overall survival with implication about the likely cause of the effect. Polycystic kidney disease is common in this transgenic line. Adverse effect of melatonin on the life span in our study may be unique to the transgenic model used and may not be relevant to the suppressive effect of melatonin in delay of mammary cancer.
Autonomic and Respiratory Characteristics of Posttraumatic Stress Disorder and Panic Disorder (2007)

Persistent hyperarousal symptoms in PTSD seem to be due to high sympathetic activity coupled with low parasympathetic cardiac control. Respiratory abnormalities were also present in PTSD. Several psychophysiological measures exhibited group-comparison effect sizes in the order of 1.0, supporting their potential for enhancing differential diagnosis and possibly suggesting utility as endophenotypes in genetic studies of anxiety disorders.
EXPERIENCE WITH TRILOSTANE IN THE TREATMENT OF CUSHING'S SYNDROME (1983)

Five patients with pituitary dependent Cushing's syndrome and two with adrenal carcinoma were treated with increasing doses of trilostane (up to 1440 mg daily). There was no consistent fall in serum cortisol levels. In addition there was no rise in the levels of precursors immediately preceding the proposed site of action of trilostane. These results suggest that trilostane does not effectively block the enzyme 3 beta-hydroxysteroid dehydrogenase delta 4,delta 5 isomerase in patients with Cushing's syndrome and that it should no longer be recommended for their treatment.
Ethics of genetic and biomarker test disclosures in neurodegenerative disease prevention trials (2015)

Considerations of risks and benefits, informed consent, and fair subject selection do not require the use of blinded enrollment for AD prevention trials. Blinded enrollment in AD prevention trials may sometimes be necessary because of the need for scientific validity, not because it prevents coercion or undue influence.
Uncoded Transmission Is Exactly Optimal for a Simple Gaussian “Sensor” Network (2008)

A single memoryless Gaussian source is observed by many terminals, subject to independent Gaussian observation noises. The terminals are linked to a fusion center via a standard Gaussian multiple-access channel. The fusion center needs to recover the underlying Gaussian source with respect to mean-squared error. In this correspondence, a theorem of Witsenhausen is shown to imply that an optimal communication strategy is uncoded transmission, i.e., each terminal's channel input is merely a scaled version of its noisy observation.
Geolocation with error analysis using imagery from an experimental spotlight SAR (2008)

This dissertation covers the development of a geometry-based sensor model for a specific monostatic spotlight synthetic aperture radar (SAR) system—referred to as the ExSAR (for experimental SAR). This sensor model facilitates single- and multiple-image geopositioning with error analysis. It allows for the use of known ground control points in refining the collection geometry parameters (a process called image resection) and for the subsequent geopositioning of other points using the resected image. Theoretically, the model also allows for the potential recovery of bias-like, persistent errors common across multiple images. The model also includes multi-image correspondence equations to aid in the cross-image identification of conjugate points. The sensor model development begins with a generic, theoretical approach to the modeling of spotlight SAR. A closed-form solution to the range and range-rate condition equations and the corresponding error propagation equation are presented. (The SAR condition equations have traditionally been solved iteratively.) The application of the closed-form solution in the image-to-ground and ground-to-image transformations is documented. The theoretical work also includes a preliminary error sensitivity analysis and a treatment of the spotlight SAR resection process. The ExSAR-specific model is established and assessed with an extensive set of images collected using the experimental radar over arrays of ground control points. Using this set, the imagery metadata elements are assessed, and the optimal element set for geopositioning is determined. The ExSAR imagery is shown to be transformed to the ground plane in only one dimension. The eventual ExSAR sensor model is used with known elevations and single-image geopositioning to show a horizontal accuracy of 8.23 m (rms). With resection using five ground-surveyed control points per image, the horizontal accuracy of reserved check points is 0.45 m (rms). Resections using the same points, but recovering fewer geometry parameters produced nearly equal accuracies. Three-dimensional geopositioning was shown feasible using the model and multiple images. Correspondence curve equations were developed and tested. These define the expected location of a conjugate point in overlapping imagery. This work includes extensive explanatory appendices, including preliminary work with bistatic SAR modeling. The experimental data set and MATLAB ® code are available.
통합 교육과 통합 STEM 교육에 대한 초등교사의 인식 (2011)

이 연구의 목적은 초등학교에서 이루어지고 있는 통합 수업과 통합 STEM 교육에 대한 초등학교 교사들의 인식을 조사하여 통합 STEM 교육을 도입하기 위한 시사점을 도출하는 데 있다. 이를 위해 대구와 경북 지역에 근무하고 있는 216명의 교사들을 대상으로 설문지를 제작하여 조사를 실시하였으며 결과는 다음과 같다. 첫째, 초등학교에서는 교과 간 통합 수업이 잘 이루어지지 않고 있었으며, 그 원인은 통합 수업 준비에 대한 부담, 교과 간 관련성에 대한 연구 부족 순으로 나타났다. 둘째, 초등 교사들은 통합 수업에 대하여 개념이나 기능의 전이가 용이하기 때문에, 창의적인 사고력과 실생활에서의 적용력을 기를 수 있기 때문에 등의 이유로 긍정적으로 생각하고 있는 것으로 나타났으며, 통합 수업 비중 확대가 필요하다고 하였다. 셋째, 초등 교사들은 교과 간 다양한 통합 수업의 유형에 대해서는 일부 유형만을 주로 사용하는 것으로 나타나 통합 수업 유형을 자유롭게 적용할 수 있는 능력을 갖추지 못한 것으로 분석되었다. 넷째, 통합 STEM 교육에 대하여 초등 교사들은 잘 모르고 있으나 필요성에 대해서는 긍정적으로 생각하는 것으로 나타났다. 다섯째, 초등 교사 들은 통합 STEM 교육이 필요한 이유에 대하여 창의력과 사고력 배양에 도움이 되기 때문에, 실생활에서의 적용력을 기를 수 있기 때문에 순으로 생각하는 것으로 나타나 통합 수업에 대한 생각과 일치하였다. 여섯째, 초등 교사들은 통합 STEM 교육을 도입하기 위해서는 통합 STEM 교육 프로그램의 개발 및 보급과 통합 STEM 교육에 대한 교사의 이해가 가장 필요하다고 생각하였다. 일곱째, 초등 교사들은 통합 STEM 교육 프로그램은 과학 교과를 중심으로 구성하는 것에 찬성하는 비중이 가장 높았고 그 이유는 다양한 분야에 응용할 수 있기 때문이라고 하였다. 여덟째, 초등 교사들은 통합 STEM 교육 프로그램은 창의적인 사고력 및 문제해결력 증진, STEM 관련 교과에 대한 학습 흥미 증진, 실생활과의 관련성의 순으로 중점을 두어 개발해야 한다고 생각하였다. 마지막으로 초등 교사들은 통합 STEM 교육이 과학기술 분야 인재양성에 긍정적인 영향을 줄 것으로 기대하였다.
Arthropod Molting Hormone: Radioimmune Assay (1972)

A radioimmune assay for the arthropod molting hormone, ecdysterone, has been developed. The sensitivity of the assay is 200 picograms or 25 times the maximum sensitivity of the bioassay. Closely related steroids also bind the anti-body, but with lower affinities.
Isolation and Identification of a Free Radical Scavenger from Cnestis ferruginca (2002)

By means of 1,1 dipheny 2 picylhydrazyl (DPPH) TLC assay, a strong free radical scavenger was detected from a MeOH extract of the leaves of Cnestis ferruginca. The free radical scavenger was isolated by reversed phase preparative chromatography and liquid chromatography, and identificated as p hydroxyphenyl 6 O trans caffeoyl β D glucopyranoside by means of HR ESI MS, NMR ( 1H, 13 C,DEPT), UV and chamical methods.The bioactivities of this compound were also discussed.
Topographic Independent Component Analysis (2001)

In ordinary independent component analysis, the components are assumed to be completely independent, and they do not necessarily have any meaningful order relationships. In practice, however, the estimated "independent" components are often not at all independent. We propose that this residual dependence structure could be used to define a topographic order for the components. In particular, a distance between two components could be defined using their higher-order correlations, and this distance could be used to create a topographic representation. Thus, we obtain a linear decomposition into approximately independent components, where the dependence of two components is approximated by the proximity of the components in the topographic representation.
<i>ASA Edition of Speech and Hearing in Communication</i> (1996)

First Page
<i>n</i>-CuInSe2/polysulfide photoelectrochemical solar cells (1982)

We report that n-type single crystals of n-CuInSe2 in aqueous polysulfide solution exhibit high quantum efficiencies of 0.8–0.9 in the wavelength region between 600–1150 nm when used as photoanodes in photoelectrochemical cells. Photocurrents of 28 mA/cm2 were measured on a ’’winter’’ day in Rehovot (71 mW/cm2) which corresponds to 40 mA/cm2 under AM1 (Air Mass 1) conditions (100-mW/cm2 sunlight). Stability tests of n-CuInSe2 photoanodes (20 000-C/cm2 photocharge passage) at short circuit current densities of 40 mA/cm2 have shown no deterioration whatsoever of the measured photocurrents.
Electroluminescence in Tetracene Crystals (1976)

Abstract dc and pulsed electroluminescence (EL) in tetracene crystals have been studied at room temperature. The crystals are provided with Na/K alloy electron injecting contact and Au semitransparent layer as a hole injecting contact. dc EL intensity shows a superlinear relationship with crystal current. EL decay indicates that the electroluminescence in tetracene consists of two components: one prompt and a second delayed component. The results can be understood if the delayed component depends upon crystal current and upon some characteristics of the active traps in the crystal. The spectral distribution of the electroluminescence as compared to photoluminescence spectrum reveals the intensive long wavelength emission. It is presumably due to trapped excitons.
Wnt-signalling and the Metabolic Syndrome (2009)

The Wnt-signalling pathway plays a well-established role in embryogenesis and tumourigenesis. However, recent data puts Wnt-signalling in the context of metabolic disease. In vitro and in vivo data characterised the role of Wnt-signalling molecules in the regulation of adipocyte differentiation (adipogenesis). Furthermore, Wnts play a pivotal role in regulating pancreatic beta-cell function and mass. In addition, studies found polymorphisms within the gene encoding TCF7L2, a Wnt-regulated transcription factor, to contribute an increased risk to develop type 2 diabetes mellitus in humans. This review will summarise recent aspects of Wnt-signalling in these pathophysiologic events and discuss the contributions of dysregulation in Wnt-signalling to features of the metabolic syndrome.
Electrical impedance tomography (EIT) in applications related to lung and ventilation: a review of experimental and clinical activities (2000)

This review article is a summary of the publications dealing with the pulmonary applications of electrical impedance tomography (EIT). Original papers on EIT lung imaging published over 15 years are analysed and several aspects of the performed EIT measurements summarized. Information on the type of the EIT device and electrodes used, the studied transverse thoracic planes, the data acquisition rate, the number of studied animals, normal subjects or patients, the kind of lung pathology, the performed ventilatory manoeuvres and other interventions, as well as the applied reference techniques, is given. The type of the generated pulmonary EIT images and the quantitative analysis of the EIT data are described. Finally, the major results achieved are presented, followed by an analysis of the perspectives of EIT in clinical applications. A comparative analysis of the EIT hardware and the quality of the evaluation tools was not performed.
Adverse reactions during biological drug therapy in psoriasis:clinical series and a review of the literature. (2011)

This work reports the adverse reactions to these biological therapies found in our patients along with a review of the literature concerning adverse reactions in psoriasis treatment. From our experience and basing ourselves on the literature reporting studies conducted in large centres, we feel that it is indispensable to continue monitoring any reactions during biological drug treatment. In this way, there is more likelihood of preventing, where possible, or better managing any reactions linked to the use of these drugs.
Thermotropic aromatic copolyesters of catechol (1992)

Abstract Three new series of thermotropic aromatic main‐chain polymers were synthesized and studied by differential scanning calorimetry and hot‐stage polarized microscopy. The polymers were random copolyesters of p ‐hydroxybenzoic acid (from 60 to 10 mol %), catechol (from 20 to 45 mol %), and one of the following dicarboxylic diacids: terephthalic acid (series 1 ), 2,6‐naphtalenedicarboxylic acid (series 2 ), and 1,2‐bis‐ p ‐carboxyphenoxy ethane (series 3 ). Copolyesters with more than 25 mol % catechol in their structures were soluble in common organic solvents such as chloroform. All the synthesized copolyesters showed hysteresis of the heat capacity at the mesophase glass transition region and nematic mesophases above their T g 's which were stable over very broad ranges of temperature. Copolyesters containing the 2,6‐naphtylenedioyl group showed the most stable nematic phases due to the increased anisometry of the 2,6‐naphtylenedioyl unit compared to that of the therephthaloyl or the 4‐oxybenzoyl units. © 1992 John Wiley & Sons, Inc.
Long-Range Forecasting: From Crystal Ball to Computer (1979)

Getting Started. Forecasting Methods. Evaluation. Comparing Methods. Commencement. Appendix. Glossary. References. UPDATED BIBLIOGRAPHY. People Index. Subject Index. Postscript.