MP76-06 USE AND EFFECTIVENESS OF PHARMACOLOGIC AND NON-PHARMACOLOGIC ERECTILE AIDS AMONG POST-PROSTATECTOMY PROSTATE CANCER SURVIVORS SEEKING TREATMENT FOR ERECTILE DYSFUNCTION: A PROSPECTIVE, MULTICENTER STUDY (2016)

You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy I1 Apr 2016MP76-06 USE AND EFFECTIVENESS OF PHARMACOLOGIC AND NON-PHARMACOLOGIC ERECTILE AIDS AMONG POST-PROSTATECTOMY PROSTATE CANCER SURVIVORS SEEKING TREATMENT FOR ERECTILE DYSFUNCTION: A PROSPECTIVE, MULTICENTER STUDY Ilan Safir, Martin Sanda, Dattatraya Patil, Catrina Crociani, Larry Hembroff, John Wei, Peter Chang, and Akanksha Mehta Ilan SafirIlan Safir More articles by this author , Martin SandaMartin Sanda More articles by this author , Dattatraya PatilDattatraya Patil More articles by this author , Catrina CrocianiCatrina Crociani More articles by this author , Larry HembroffLarry Hembroff More articles by this author , John WeiJohn Wei More articles by this author , Peter ChangPeter Chang More articles by this author , and Akanksha MehtaAkanksha Mehta More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1857AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Erectile dysfunction (ED) is the most common health-related quality of life complaint following prostate cancer (CaP) treatment. We assessed use and effectiveness of various pharmacologic and non-pharmacologic erectile function aids following radical prostatectomy (RP). METHODS Baseline sexual function and post-RP use and effectiveness of erectile aids were assessed in a prospective, longitudinal, multicenter cohort study of men with prostate cancer (Prostate Cancer Outcomes and Satisfaction with Treatment Quality Assessment) using the validated EPIC-26 questionnaire. Erectile aids included phosphodiesterase-5 inhibitors (PDE5i), intraurethral alprostadil (IA), intracavernosal injection (ICI), and vacuum erection device (VED). Follow-up was 2 years. Primary outcome measures were self-reported use of erectile aids and erection quality. Univariate and multivariate logistic regression was used for analysis. Randomness of loss to follow-up was assessed with sensitivity analysis. RESULTS Of 589 men who underwent RP, 334 subjects reported use of at least one erectile aid at 2 years. Frequency of use, and effectiveness of erectile aids, is summarized in Table 1. Factors associated with responsiveness to ED treatment included age, number of comorbidities, baseline PSA, prostate volume, and D'Amico risk stratification. Effectiveness of oral PDE5i was the best predictor of erection quality, defined as erection firm enough for penetration, and sexual satisfaction two years after RP. Of the 140 men in whom PDE5i were ineffective, 35, 39, and 39 subjects tried IA, ICI, and/or VED, respectively; there was no significant difference in the effectiveness of these three aids in this subset of men. Only 4/140 subjects reported achieving an erection firm enough for penetration using these three aids. CONCLUSIONS Almost all men seeking treatment for ED try PDE5i following surgery. Over 50% of these men report effectiveness of PDE5i 2 years following RP. In cases where PDE5i are ineffective, IA, ICI, and VED may be used for treatment of ED, but erection quality remains poor despite the use of these erectile aids. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1008-e1009 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Ilan Safir More articles by this author Martin Sanda More articles by this author Dattatraya Patil More articles by this author Catrina Crociani More articles by this author Larry Hembroff More articles by this author John Wei More articles by this author Peter Chang More articles by this author Akanksha Mehta More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...