gebhart/patrepeval huggingface dataset:
Two Nucleotide Transport Proteins in <i>Chlamydia trachomatis</i> , One for Net Nucleoside Triphosphate Uptake and the Other for Transport of Energy (1999)

The genome of Chlamydia trachomatis, one of the most prominent human pathogens, contains two structural genes coding for proteins, herein called Npt1Ct and Npt2Ct (nucleoside phosphate transporters 1 and 2 of C. trachomatis), exhibiting 68 and 61% similarity, respectively, to the ATP/ADP transporter from the intracellular bacterium Rickettsia prowazekii at the deduced amino acid level. Hydropathy analysis and sequence alignments suggested that both proteins have 12 transmembrane domains. The putative transporters were expressed as histidine-tagged proteins in Escherichia coli to study their biochemical properties. His10-Npt1Ct catalyzed ATP and ADP transport in an exchange mode. The apparent Km values were 48 (ATP) and 39 (ADP) microM. ATP and ADP transport was specific since AMP, GTP, CTP, UTP, dATP, dCTP, dGTP, and dTTP did not inhibit uptake. In contrast, His10-Npt2Ct transported all four ribonucleoside triphosphates with apparent Km values of 31 microM (GTP), 302 microM (UTP), 528 microM (CTP), and 1,158 microM (ATP). Ribonucleoside di- and monophosphates and deoxyribonucleotides were not substrates. The protonophore m-chlorocarbonylcyanide phenylhydrazone abolished uptake of all nucleoside triphosphates by Npt2Ct. This observation indicated that His10-Npt2Ct acts as a nucleosidetriphosphate/H+ symporter energized by the proton motive force across the Escherichia coli cytoplasmic membrane. We conclude that Npt1Ct provides chlamydiae with energy whereas Npt2Ct catalyzes the net uptake of ribonucleoside triphosphates required for anabolic reactions.
Analytical and numerical study of hardcore bosons in two dimensions (2002)

We study various properties of bosons in two dimensions interacting only via on-site hardcore repulsion. In particular, we use the lattice spin-wave approximation to calculate the ground-state energy, the density, the condensate density, and the superfluid density in terms of the chemical potential. We also calculate the excitation spectrum, \ensuremath{\omega}(k). In addition, we perform high precision numerical simulations using the stochastic series expansion algorithm. We find that the spin-wave results describe extremely well the numerical results over the whole density range 0\ensuremath{\leqslant}\ensuremath{\rho}\ensuremath{\leqslant}1. We also compare the lattice spin-wave results with continuum results obtained by summing the ladder diagrams at low density. We find that for \ensuremath{\rho}\ensuremath{\leqslant}0.1 there is good agreement, and that the difference between the two methods vanishes as ${\ensuremath{\rho}}^{2}$ for $\stackrel{\ensuremath{\rightarrow}}{\mathrm{\ensuremath{\rho}}}$0. This offers the possibility of obtaining precise continuum results by taking the continuum limit of the spin-wave results for all densities. Finally, we study the finite-temperature phase transition numerically for the entire density range, and compare with low density predictions.
On Jonson and Shakespeare (2010)

The Critical Heritage gathers together a large body of critical sources on major figures in literature. Each volume presents contemporary responses to a writer's work, enabling students and researchers to read the material themselves.
Channel-Aware Distributed Scheduling For Ad-Hoc Communications With Capture (2007)

In this paper, we consider contention-based ad-hoc networks, where links use mini-slots to contend for the channel (i.e., channel probing), and followed by data transmission over a longer duration, as in CSMA. We investigate channel-aware distributed scheduling under the multipacket reception (MPR) model, which involves a joint process of channel probing and distributed scheduling. In this study, we formulate channel- aware distributed scheduling as a team game, with the objective being to maximize the overall network throughput. We use optimal stopping theory to tackle this problem, and show that the optimal policy for distributed scheduling has a threshold structure. Observing that the network throughput depends heavily on the contention probabilities of links, we then generalize the study to jointly optimize the rate thresholds and the contention probabilities, and propose a two-stage algorithm for computing the optimal threshold-probability pair by invoking fractional optimization and convex programming.
Machining Process Modeling: A Review (1997)

In this paper, a summary of work performed in the area of modeling of the dynamic metal cutting process is presented. A general view of evolution of the dynamic cutting process models is depicted. Specifically four modeling approaches including analytical, experimental, mechanistic and numerical methods are critically reviewed. A brief assessment of future research needs is also given.
Expression pattern of different gap junction connexins is related to embryo implantation (1996)

Successful implantation in mammals requires a close interaction between the embryo and the uterus. Direct cell-cell communication via gap junctions seems to play an important role in the preparation of the uterus for embryo implantation and in the regulation of trophoblast invasion. During preimplantation in the rat the gap junctional proteins connexin (cx) 26 and cx43 are suppressed. This loss of cell-cell communication seems to be important for transformation of the endometrium into the receptive phase. The suppressive effect is mediated by progesterone as demonstrated by the application of antigestagens. At implantation, however, a spatial and temporal pattern of connexin expression is induced in response to embryo recognition. cx26 is locally expressed in the uterine epithelium of the implantation chamber, cx43 in the surrounding decidua prior to invasion. With progressing invasion, the decidual cells surrounding the invading trophoblast in addition to cx43 reveal cx26. In this phase, the invasive partner, the blastocyst, is characterized by coexpression of cx43 and cx31. During trophoblast invasion however, cx31 becomes restricted to the cells of the invasive ectoplacental cone, cx43 to the embryo proper. It seems that compartmentalization of the trophoblast and the inner cell mass is established by two different connexins. During placental differentiation connexin expression switches from cx31 to cx26 and cx43, indicating the end of the invasive phase. The highly regulated pattern of connexin expression in the endometrium as well as in the trophoblast suggests a key role of this different intercellular pathways in regulating the invasion process of the trophoblast into its host tissue, the endometrium.
Graphene thickness dependent adhesion force and its correlation to surface roughness (2014)

In this paper, adhesion force of graphene layers on 300 nm silicon oxide is studied. A simple model for measuring adhesion force for a flat surface with sub-nanometer roughness was developed and is shown that small surface roughness decreases adhesion force while large roughness results in an effectively larger adhesion forces. We also show that surface roughness over scales comparable to the tip radius increase by nearly a factor of two, the effective adhesion force measured by the atomic force microscopy. Thus, we demonstrate that surface roughness is an important parameter that should be taken into account in analyzing the adhesion force measurement results.
Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria (2013)

These data show that slow and continuous delivery of lower doses of nimodipine improves survival of mice with ECM in rescue therapy with artesunate while showing a safer profile in terms of cardiovascular effects.
Surface expression of murine leukemia virus structural polypeptides on host cell and the virion (1978)

The expression of murine leukemia virus structural polypeptides on the surface of cells producing exogenous Friend leukemia virus, endogenous ecotropic AKR and xenotropic BALB/c virus was investigated. Antisera to Friend virus gp71, p30, p15E, p12 and p10 were employed in a complement-dependent chromium release assay and to immunoprecipitate lactoperoxidase iodinated surface polypeptides prior to analysis in polyacrylamide gel electrophoresis. With the latter technique gag-gene encoded proteins and their precursors were not discovered on the viral and cellular surface membranes. Only env-gene encoded polypeptides gp85, gp71, and p15E were detectable. p15E is embedded into the lipid membrane. gp85 is formed by disulfide linkage of p15E to surface-exposed gp71. The ratio of gp71 to gp85 is variable and apparently determined by the host cell. Antibodies of strong cytotoxicity are those against type- and group-specific epitopes of gp71 as well as type-specific epitopes of p12.
Phytoremediation of Soil Trace Elements (2010)

This chapter contains sections titled: Introduction The Nature of Soil Contamination where Phytoextraction may be Applied Need for Metal-Tolerant Hyperaccumulators for Practical Phytoextraction Phytoremediation Strategies: Applications and Limitations Phytostabilization of Zinc-Lead, Copper, or Nickel Mine Waste or Smelter-Contaminated Soils Recovery of Elements from Phytoextraction Biomass Risks to Wildlife during Phytoextraction Operations Conclusions References
[Anomalous dispersion of the optical activity of dolphin myoglobin and horse hemoglobin]. (1967)

We have started the structure determination of the dimerization domain of LFB1 in solution by nuclear magnetic resonance in order to elucidate the way that the LFB1 protein dimerizes and then interacts with DNA. A 32 amino acid peptide was synthesized, and full assignment of the NMR resonances in acidic solution was achieved. The secondary structure determination is presented here. Three structurally distinct regions can be distinguished. The N-terminal region from residues 1 to 6 is extended. Two helical regions span from residues 7 to 18 and from 23 to 32. The absence of dipolar effects involving residues more than four positions apart in the sequence excludes the possibilities both of a four-helix bundle formed by two hairpins and of an antiparallel dimer; the domain must therefore be arranged as a parallel dimer formed by kinked monomers. This structural solution presents important differences from the leucine zipper-type structure observed in other transcriptional activators. Although further studies are still necessary to determine the 3D structure of the peptide, we can exclude the possibility of a coiled-coil structure.
„Kulturmanagement“: Ermöglichen, Gestalten, Verantworten (1991)

„Kulturmanagement“, „Kulturmanager“ oder gar „Diplom-Kulturmanager“ — wo immer die Bezeichnungen im Gespräch auftauchen, sie erzeugen einerseits Aufmerksamkeit und Interesse, andererseits Skepsis oder gar spontane Ablehnung.
Influence of spinning velocity on mechanical and structural behavior of PET/nylon 6 fibers (1995)

Abstract Influence of spinning velocities on the mechanical and structural properties of polyethylene terephthalate (PET)/nylon 6 blend fibers have been reported. Fibers of PET/nylon 6 containing a small percentage of nylon (5% by weight) have been melt‐spun at 3 different spinning velocities (2,900; 3,200; 3,600 m/min). The fibers have been characterized by thermal, morphological, structrual, and mechanical analysis. Various techniques such as SEM, DSC, X‐ray diffraction, hot water shrinkage (HWS), viscosity, and birefringence have been used. SEM analysis revealed that in the blend, nylon 6 is well‐dispersed as spheres in the PET matrix. The blend shows a marked decrease in the melt‐flow index, which in turn leads to a beneficial effect on the rheological properties of the PET without negatively influencing its mechanical characteristics. This finding results in a saving on energetical requirements of the processing, as both temperature and pressure of spinning can be decreased. © 1995 John Wiley & Sons, Inc.
Browsing help for faster document retrieval (2004)

In this paper, the search engine Intuition is described. It allows the user to navigate through the documents retrieved with a given query. Several "browse help" functions are provided by the engine and described here: conceptualisation, named entities, similar documents and entity visualization. They intend to "save the user's time". In order to evaluate the amount of time these features can save, an evaluation was made. It involves 6 users, 18 queries and the corpus is made of 16 years of the newspaper Le Monde. The results show that, with the different features, a user get faster to the needed information. fewer non-relevant documents are read (filtering) and more relevant documents are retrieved in less time.
Ultrasound contrast microbubbles targeted to tumor angiogenesis specifically bind tumor-derived endothelial cells (2002)

Angiogenesis is a key phenomenon in the continued growth of clinically-significant tumors. Endothelial cells (ECs) of tumor vasculature are phenotypically dissimilar from those in normal tissues, and are characterized by altered expression of molecular markers on the EC surface. Various peptides have been identified that specifically bind to tumor angiogenic endothelium, including the tripeptide Arg-Arg-Leu (MW3). Previously, we have shown that lipid-based ultrasound contrast microbubbles (MBs) can be specifically targeted to EC inflammatory markers. Here, we hypothesized that MBs targeted via MW3 would specifically adhere to tumor angiogenic ECs in vitro. Microbubbles were conjugated via avidin/biotin bridging chemistry to cyclic peptides containing either MW3 or glycine control tripeptides. In a parallel plate chamber, MBs were perfused across coverslips of cultured human coronary artery ECs (HCAECs) or mouse tumor-derived ECs (TDECs) (3 min; wall shear rate 100s/sup -1/) and washed. Adhesion to ECs was quantified in 20 random microscopic fields per coverslip. MW3-MB adherence was 3 to 6-fold greater than glycine-MB (p<0.01). MW3-MB adherence to TDECs was 3 times greater than to HCAECs (p<0.01). These data demonstrate that MW3-MBs specifically adhere to tumor angiogenic ECs in vitro, potentially offering a means for noninvasive functional imaging of tumor neovascularization and therapeutic tumor targeting.
ChemInform Abstract: Dynamic Electrochemistry: Methodology and Application (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
GPS Carrier‐Phase Time Transfer Using Single‐Difference Integer Ambiguity Resolution (2008)

GPS is widely used for time and frequency transfer. To estimate the clock difference between two ground stations, a single baseline solution can be performed using external products for the modelling of the geometrical effects (constellation ephemeris and station coordinates). The baseline solution relies on a single‐difference formulation, using code and phase ionosphere‐free measurements. The phase ambiguities are usually adjusted as floating parameters. Such solutions give very good results when modelling hypotheses are consistent between the external solution (e.g., GPS orbits) and the baseline solution. However, the frequency bias in the computed clock is very sensitive to discrepancies in the models, and is only observed thanks to the code measurement, with limitations due to the noise. Here, we propose to solve the integer ambiguities on single‐difference phase measurements. The advantage is the complete elimination of the clock drifts observed in floating ambiguities solutions. This formulation allows also a reliable continuous connection between overlapping clock solutions (jumps between such solutions can be completely eliminated). Several time transfer results are analyzed and compared to TWSTFT. The methodology has been extended to a network of stations using integer ambiguities on zero‐difference measurements. The corresponding results are given for a few European stations.
Cooperative Transportation of a Flexible Object Towards Construction of a Martian Habitat (2009)

Future space exploration will likely include teams of autonomous robots that can perform various tasks in order to minimize human risk and maximize mission efficiency. One particular task may include the autonomous construction of a lunar or Martian habitat to prepare for long-duration human habitation on an extraterrestrial surface. This paper describes the development of an autonomous team of two robots that cooperatively transports a long construction object. Three major aspects of the project are discussed: the measurement of robot states, the design of cooperative control laws that govern the motion of the two-robot team, and the design of the central-PC infrastructure.
OVARIAN BIOCHEMICAL COMPETENCE FOLLOWING GONADOTROPHIC DEPRIVATION FROM BIRTH (1976)

Normal ovarian morphogenesis is impaired by the absence of gonadotrophic hormones from birth. In the present study, the following question was asked: Does gonadotrophic deprivation also affect ovarian biochemical competence? Newborn mice were treated daily with an antiserum neutralizing endogenous circulating gonadotrophins. At the age of 14 days, ovaries from these mice and control littermates were incubated in the presence and absence of gonadotrophic preparations; cAMP and lactic acid levels were then measured in tissue and incubation medium. Ovaries from anti-gonadotrophin treated and control mice had the same basal levels, per mg tissue, of cAMP and lactic acid. Moreover, the levels increased to approximately the same extent following in vitro gonadotrophic stimulation: an increase in cAMP of 8-10-fold (using a preparation with an hLH:hFSH ratio of 1:1) or 2 1/2-fold (using a preparation with an hLH:hFSH ratio of 1:5), and about a 2-fold increase in lactic acid (using oLH). The acute effect of gonadotrophins on ovarian glycolysis, reported up till now only in the rat ovary, is the first such demonstration in mice. The results also indicate that despite impaired morphogenesis, the enzymatic systems necessary for ovarian glycolysis (as measured by lactic acid production) and cAMP formation can develop without gonadotrophic participation. Furthermore, ovarian capacity to respond to hormonal stimulation is acquired post-natally, as shown by refractoriness to gonadotrophic stimulation during the first week of life. Finally, post-natal gonadotrophic exposure does not seem an essential requirement, at least as measured by the above parameters, for acquiring ovarian competence to respond to hormonal stimulation.
Chromatin Challenges during DNA Replication: A Systems Representation (2007)

In a recent review, A. Groth and coworkers presented a comprehensive account of nucleosome disassembly in front of a DNA replication fork, assembly behind the replication fork, and the copying of epigenetic information onto the replicated chromatin. Understanding those processes however would be enhanced by a comprehensive graphical depiction analogous to a circuit diagram. Accordingly, we have constructed a molecular interaction map (MIM) that preserves in essentially complete detail the processes described by Groth et al. The MIM organizes and elucidates the information presented by Groth et al. on the complexities of chromatin replication, thereby providing a tool for system-level comprehension of the effects of genetic mutations, altered gene expression, and pharmacologic intervention.
Calibrations for minimal networks in a covering space setting (2019)

In this paper, we define a notion of calibration for an approach to the classical Steiner problem in a covering space setting and we give some explicit examples. Moreover, we introduce the notion of calibration in families: the idea is to divide the set of competitors in a suitable way, defining an appropriate (and weaker) notion of calibration. Then, calibrating the candidate minimizers in each family and comparing their perimeter, it is possible to find the minimizers of the minimization problem. Thanks to this procedure we prove the minimality of the Steiner configurations spanning the vertices of a regular hexagon and of a regular pentagon.
ChemInform Abstract: KONFIGURATIVE BEVORZUGUNG DER P‐METHYL‐GRUPPIERUNG BEI EINIGEN PHOSPHORINANEN (1972)

Abstract 1‐Methyl‐4‐phosphorinanon (I) liefert mit zahlreichen Reduktionsmitteln wie Natrium/Äthanol, Kaliumboranat, Natriumtrimethoxyborhydrid, Tri‐tert.‐ butoxyaluminiumhydrid auf katalytischem Wege oder durch Verwendung von tert.‐Butylmagnesiumchlorid die beiden Carbinole (II) und (III) zu gleichen Anteilen.
An Experiment in Intensive Probation with Boys (1962)

For the past two years an experiment in intensive probation among boy probationers has been in progress at the Cleveland juvenile court; recently it was deemed successful enough to warrant establishment of the service on a quasi-permanent basis. The broad eligibility criterion is that the boy must present difficulties so serious that he seems unlikely to respond to con ventional probation service but might be amenable to excep tionally intensive and skillful probation. Typically, intensive probation service has involved approximately three times as much service per case as conventional probation. Returns to date indicate that approximately 60 per cent of the youngsters treated on the intensive probation program have shown ap preciable progress toward rehabilitation.
Degradation of Endogenous and Exogenous Genes of Roundup-Ready Soybean during Food Processing (2005)

Roundup-Ready soybeans have been genetically modified to resist the effects of the herbicidal glyphosate and have become the most prevalent transgenic crop in the world. In this work, Roundup-Ready soybeans were used as raw material to study the effects of critical processing procedures such as grinding, cooking, blending, homogenization, sterilization, and spray-drying on the length of DNA fragments of an endogenous gene (lectin) and an exogenous gene (epsps) examined in material from three soybean foods of bean curd, soy milk, and soy powder and from samples taken during their processing. The results showed that various processing procedures caused degradations of both the endogenous and exogenous genes to different degrees. In the grinding procedure, endogenous gene DNA was degraded from 1883 to approximately 836 bp, and exogenous gene DNA was degraded from 1512 to approximately 408 bp. In the blending and squeeze-molding procedures, exogenous gene DNA was also degraded from about 408 to 190 bp, but there was no obvious action on the endogenous gene. After the endogenous and exogenous genes had been degraded to some degree, such as 836 and 408 bp, respectively, they were not evidently affected by cooking procedure at 100 degrees C for 15 min. However, the endogenous gene was further considerably degraded from around 836 to 162 bp in the sterilization procedure at 121 degrees C for 30 s. The effect of the homogenization step on endogenous and exogenous genes was similar to that of the cooking procedure. The coagulation procedure, principally a biochemical reaction, did not greatly affect the exogenous gene but did affect endogenous gene, reducing DNA size from about 836 to 407 bp. Furthermore, the spray-drying procedure, a process of physical shearing, high temperature, and sudden high pressure, distinctly caused degradation of both the lectin and epsps genes, rapidly decreasing the sizes from about 836 to 162 bp for the endogenous gene and from about 408 to 190 bp for the exogenous gene.
Thermodynamics of High-Entropy Alloys and Alloy Design Presented by NETL at MS&T 2019, 03/19 (2020)

Presented by NETL at MS&T 2019, 03/19