gebhart/patrepeval huggingface dataset:
Clinical, histologic, and ultrastructural evaluation of tattoos treated with three laser systems (1994)

We examined the response of tattoo pigments treated with three commercially available lasers: Q-switched ruby, Q-Switched neodynium:yttrium,aluminum,garnet (Nd:YAG), and the alexandrite. Tattoos applied to hairless guinea pigs and treated with the aforementioned lasers were evaluated clinically, histologically, and ultrastructurally. Clinical evaluation showed red brown, dark brown, and orange pigment responded best to the Nd:YAG laser (1064 nm). The alexandrite laser was most effective for removing blue and green pigment, the Q-switched ruby laser was most effective for removing purple and violet pigment, and the Nd:YAG laser (532 nm) removed red pigment the best. Black pigment was lightened equally with the Nd:YAG laser (1064 nm) and (532 nm) and the alexandrite laser (755 nm). No clinical scarring was observed; however, some colors turned black after treatment. Histologic and ultrastructural examination showed epidermal and dermal damage to be most evident after treatment with the Nd:YAG laser. Our study shows that certain tattoo pigments respond better to different laser systems.
Autoclave heat treatment for prealloyed powder products (1973)

Technique could be applied directly to loose powders as part of hot pressing process of forming them to any required shapes. This would eliminate initial extrusion step commonly applied to prealloyed powders, substantially reduce cost of forming operation, and result in optimum properties.
Genetic Algorithms in Visual Art and Music (2002)

April 01 2002 Genetic Algorithms in Visual Art and Music Colin G. Johnson, Colin G. Johnson Computing Laboratory University of Kent at Canterbury Canterbury Kent, CT2 7NF U.K. E-mail: C.G.Johnson@ukc.ac.uk Search for other works by this author on: This Site Google Scholar Juan Jesús Romero Cardalda Juan Jesús Romero Cardalda Information and Communications Technology Department University of A Coruña 15071 A Coruña Spain E-mail: jj@udc.es Search for other works by this author on: This Site Google Scholar Author and Article Information Colin G. Johnson Computing Laboratory University of Kent at Canterbury Canterbury Kent, CT2 7NF U.K. E-mail: C.G.Johnson@ukc.ac.uk Juan Jesús Romero Cardalda Information and Communications Technology Department University of A Coruña 15071 A Coruña Spain E-mail: jj@udc.es Juan Jesús Romero Cardalda is a computer scientist and a musician. He works at present as an associate teacher in the Creative Computer Line of RNASA-GIB Lab in the University of A Coruña, Spain. He works with evolutionary computation and other computational techniques and applies these to obtain creative computation in tasks such as the composition of music. His present research focuses on the idea of Hybrid Society, which consists of an egalitarian society composed of creative computers and human beings. Colin Johnson is a lecturer in computer science at the University of Kent in England. He has research interests in several areas involving the combination of ideas from mathematics and computing with ideas from biology. This includes work on simulating biological systems and work on the use of biological metaphors as inspiration for novel ways of doing computing. Hs is also interested in music and media technologies and is an active musician both as composer and performer. Online ISSN: 1530-9282 Print ISSN: 0024-094X © 2002 ISAST2002 Leonardo (2002) 35 (2): 175–184. https://doi.org/10.1162/00240940252940559 Cite Icon Cite Permissions Share Icon Share Facebook Twitter LinkedIn MailTo Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Colin G. Johnson, Juan Jesús Romero Cardalda; Genetic Algorithms in Visual Art and Music. Leonardo 2002; 35 (2): 175–184. doi: https://doi.org/10.1162/00240940252940559 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsLeonardo Search Advanced Search This content is only available as a PDF. © 2002 ISAST2002 Article PDF first page preview Close Modal You do not currently have access to this content.
Automated Vehicles in Cities: A First Step Towards the Automated Highway (1998)

<div class="htmlview paragraph">The concept of the automated highway has been around for several decades. However, even if the technology has much progressed and has been demonstrated recently in quite elaborate forms, it is still unclear how it can be deployed realistically. The manufacturers now seem to propose a very gradual approach through the introduction of driving aids such as active trajectory control (ABS and ESP), adaptive cruise control (ACC), collision warning and vigilance monitoring.</div> <div class="htmlview paragraph">Here, we take the stand that a more disruptive process can take place with fully automated vehicles deployed locally as a public transport system based on individual vehicles. These vehicles would use dedicated road tracks, more or less protected from the intrusion of other vehicles. Later in the process of deployment of these dedicated roads, they could be made available to private vehicles equipped with driving automation.</div>
Ion trap collisional activation of the deprotonated deoxymononucleoside and deoxydinucleoside monophosphates (1995)

Deoxymononucleoside and deoxydinucleoside monophosphate anions formed by electrospray have been subjected to ion trap collisional activation. The threshold for decomposition via loss of base is significantly lower for the deoxymononucleoside 3'-monophosphates than for the corresponding 5'-monophosphates, which indicates that the presence of a charged 3' phosphate group facilitates base loss. The behavior of the bases among each class of isomers shows slight variation in threshold and tandem mass spectrometry efficiency with tile notable exception of 2'-deoxyguanosine 5'-monophosphate. This ion is exceptionally stable toward decomposition via base loss, which reflects a strong hydrogen bonding interaction between the base and the phosphate group. All dinucleotides fragment via similar mechanisms, but the propensity for neutral base loss relative to loss of a charged base is highly dependent on the identities of both the 5' and 3' bases. The behavior of the dinucleotides under collisional activation conditions supports the proposal that base loss proceeds via a proton-bound dimer intermediate in which loss of the charged base directly competes with loss of the neutral base. Application of the kinetic method allows for quantitative predictions of the differences of the gas-phase acidities of the dimer components.
A Study on Modeling with Consideration of Dependence of Vehicle Velocity (2002)

This paper focuses on the tire force characteristics related to the vehicle speed. We constructed a mechanical tire model using a Voigt-Type viscoelastic spring system for the tread rubber. And, we analyze the force distribution along the contact length, the dependence of vehicle speed to the tire forces and the moments to a change in side slip angle and coefficient of viscosity. Finally, it is shown that the tire model has good agreement with actual measurements results qualitatively, and also it is found that the characteristics of lateral force have independence to the vehicle speed.
Performance evaluation of a system of interconnected CSMA/CD LANs via an N-port bridge (2003)

A composite local-area network (LAN) consisting of CSMA/CD (carrier-sense multiple-access/collision detection) LANs connected via an N-port bridge is considered. The composite LAN performance is evaluated for bridge priority protocols, in which the bridge is persistent and does not back off, whereas the stations access the channel according to the controlled nonpersistent protocol. The bridge interconnected system is compared to a system in which the bridge is replaced by a repeater, and the performance advantages of the former system over the latter are quantified.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
PDE1 Inhibition: Potential for the Treatment of Cognitive Impairment (2017)

Medicinal Chemistry Reviewsis an outstanding 600 page volume providing timely and critical reviews of important topics in medicinal chemistry. It is provided free of charge to MEDI members in electronic format. Members can also order a print copy, for the cost of printing, shipping and handling
FUNDAMENTAL STUSY ON ESTIMATION OF ORIGIN OF COASTAL SEDIMENT USING RARE EARTH ELEMENTS AND STRONTIUM ISOTOPES (2015)

浅海域における物質循環健全化の鍵として干潟や浅場の再生・保全へ向けた活動が進んでいる．干潟や浅場の形成には，河川からの流入土砂の供給と湾内での漂砂移動が重要となるが，土砂供給源の起源推定に関する有効な手法は確立されていない．そこで本研究では，干潟の再生が進む三河湾において，流入する主要河川である豊川・矢作川，河口干潟の土壌堆積物を採取し，51元素の質量分析，およびストロンチウム同位体比の分析を行い，こうした元素濃度や組成比が，干潟構成材の起源推定における化学的なトレーサーとして有効であるのか検討を行った．その結果ストロンチウム同位体比は堆積物の地質情報を良く表しており，希土類含有量のクラスター分析と組み合わせることで，堆積物の起源推定をより正確に推定できる可能性が示唆された．
Reduction and Reductive Coupling of Imines by Sm(II)‐Based Reagents. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Bit error rate in an asynchronous DS/CDMA system using Markovian SS codes (2003)

SS codes generated by a Markov chain are shown to be superior to LFSR-based codes and i.i.d. codes in an asynchronous DS/CDMA system in terms of the following two common performance measures: 1) acquisition rate; and 2) bit error rate of the correlator using all accumulated version of the serial search acquisition method.
Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor (2016)

Morphology of migrating cells is regulated by Rho GTPases and fine-tuned by protein interactions and phosphorylation. PKA affects cell migration potentially through spatiotemporal interactions with regulators of Rho GTPases. Here we show that the endogenous regulatory (R) subunit of type I PKA interacts with P-Rex1, a Rac guanine nucleotide exchange factor that integrates chemotactic signals. Type I PKA holoenzyme interacts with P-Rex1 PDZ domains via the CNB B domain of RIα, which when expressed by itself facilitates endothelial cell migration. P-Rex1 activation localizes PKA to the cell periphery, whereas stimulation of PKA phosphorylates P-Rex1 and prevents its activation in cells responding to SDF-1 (stromal cell-derived factor 1). The P-Rex1 DEP1 domain is phosphorylated at Ser-436, which inhibits the DH-PH catalytic cassette by direct interaction. In addition, the P-Rex1 C terminus is indirectly targeted by PKA, promoting inhibitory interactions independently of the DEP1-PDZ2 region. A P-Rex1 S436A mutant construct shows increased RacGEF activity and prevents the inhibitory effect of forskolin on sphingosine 1-phosphate-dependent endothelial cell migration. Altogether, these results support the idea that P-Rex1 contributes to the spatiotemporal localization of type I PKA, which tightly regulates this guanine exchange factor by a multistep mechanism, initiated by interaction with the PDZ domains of P-Rex1 followed by direct phosphorylation at the first DEP domain and putatively indirect regulation of the C terminus, thus promoting inhibitory intramolecular interactions. This reciprocal regulation between PKA and P-Rex1 might represent a key node of integration by which chemotactic signaling is fine-tuned by PKA.
A rich internet application for remote visualization and collaborative annotation of digital slides in histology and cytology (2013)

info:eu-repo/semantics/published
[Interactions between pigments and nucleic acids. 5. Stoichiometry of complex 1 formed between luteoskyrine, magnesium ions and nucleic acids]. (1968)

Luteoskyrine can be bound to nucleic acids in presence of Mg 2+ ions. Two types of complexes are found. Complex I is made with single stranded nucleic acids containing purine bases such as denatured DNA, heated apyrimidinic acid, poly adenylic acid, poly inosinic acid or heated poly guanylic acid. Its visible spectrum is shifted towards shorter wavelengths compared to that of free luteoskyrine. Complex II is formed with double stranded nucleic acids or with single stranded ones deprived of purine bases such as a purinic acid, poly uridylic or poly cytidylic acid. The visible spectrum of complex II is shifted towards longer wavelengths with respect to that of free pigment. In complex I, one mole of luteoskyrine is associated to one atom of magnesium. Prolonged dialysis or heating does not dissociate the magnesium from the complex I but addition of EDTA does, with the simultaneous appearance of the free dye spectrum. Any purine residue in a polynucleotide is a potential site for complex I formation, but neither the nature of the purine (adenine or guanine) nor the nature of the sugar (ribose or deoxyribose) is relevant. However, the maximum amount of luteoskyrine bound as complex I by poly adenylic acid corresponds to a dye/purine ratio of 1/2. This ratio is somewhat larger with the denatured DNAs studied, being comprised between 1/1,2 and 1/1,7. It is suggested that this limit for complex I formation results from steric hindrance due to the size of the luteoskyrine molecule. Being bound to a given purine residue, a luteoskyrine molecule hinders the approach of another dye molecule to the adjacent purine residue but not to the one second next. According to this hypothesis, the maximum amount of complex I formed with given DNA can be calculated from the frequencies of purines sequences, and the predictions made correspond to the observed values. It is therefore likely that the stoechiometry of complex I corresponds to the association of one purine residue, one molecule of luteoskyrine and one atom of magnesium. To be able to bind luteoskyrine and magnesium as a complex I, a purine‐containing oligo‐nucleotide has to have a certain minimum size of 5 to 6 nucleotides (at 20 °). This suggests that a certain conformation of the relevant purine nucleotide residue is required for the binding of luteoskyrine as complex I.
Endogenous Fms-like Tyrosine Kinase-3 Ligand levels are not altered in mice after a severe burn and infection (2009)

These data suggest that the beneficial effects of Flt3L treatments after burn injury are not due to correction of a burn-associated Flt3L deficiency but rather, are likely due to supplementary stimulation of DC production and immune responses to infection.
Reciprocal entorhinal-hippocampal connections established by human fetal midgestation (1996)

Little is known about the timing or sequence of genesis of connections between different areas of the developing human cerebral cortex. It has been shown that connections between areas V1 and V2 of the visual isocortex are established at about 37 weeks of gestation (Burkhalter [1993] Cerebr. Cortex 3:476-487), suggesting that cortico-cortical connections appear late in the 40-week human gestational period. However, there are indications from other studies that connections between subdivisions of the hippocampal formation may be established much earlier, by about 20 weeks of human gestation. To investigate this possibility, the lipophilic bidirectional tracer 1,1' dioctadecyl-3,3,3',3-tetramethylindocarbocyanine perchlorate (DiI) was used to study connections between the entorhinal cortex, hippocampus, and temporal lobe neocortex in paraformaldehyde-fixed postmortem fetal tissue. The DiI transport revealed robust reciprocal connections between the entorhinal cortex, hippocampus, and subiculum, which were consistently present at 19 weeks of gestation (the earliest age studied), and which were anatomically similar to those in adult primates. Specifically, projections to the hippocampus and subiculum originated from neurons in the entorhinal cortex (EC) layers 2 and 3, whereas reciprocal projections to the EC originated from pyramidal neurons in the cornu ammonis region CA1 and the subiculum. In contrast, the perforant pathway projection from EC to the dentate gyrus, and all connections with the neocortex, reached only rudimentary stages of development by 22 weeks of gestation (the latest age studied). These findings suggest that hippocampal pathways develop prior to isocortical pathways, and that reciprocal entorhinal-hippocampal projections may be among the first cortico-cortical connections to be established in the human brain.
Candida albicans Isolates from the Gut of Critically Ill Patients Respond to Phosphate Limitation by Expressing Filaments and a Lethal Phenotype (2012)

Candida albicans is an opportunistic pathogen that proliferates in the intestinal tract of critically ill patients where it continues to be a major cause of infectious-related mortality. The precise cues that shift intestinal C. albicans from its ubiquitous indolent colonizing yeast form to an invasive and lethal filamentous form remain unknown. We have previously shown that severe phosphate depletion develops in the intestinal tract during extreme physiologic stress and plays a major role in shifting intestinal Pseudomonas aeruginosa to express a lethal phenotype via conserved phosphosensory-phosphoregulatory systems. Here we studied whether phosphate dependent virulence expression could be similarly demonstrated for C. albicans. C. albicans isolates from the stool of critically ill patients and laboratory prototype strains (SC5314, BWP17, SN152) were evaluated for morphotype transformation and lethality against C. elegans and mice during exposure to phosphate limitation. Isolates ICU1 and ICU12 were able to filament and kill C. elegans in a phosphate dependent manner. In a mouse model of intestinal phosphate depletion (30% hepatectomy), direct intestinal inoculation of C. albicans caused mortality that was prevented by oral phosphate supplementation. Prototype strains displayed limited responses to phosphate limitation; however, the pho4Δ mutant displayed extensive filamentation during low phosphate conditions compared to its isogenic parent strain SN152, suggesting that mutation in the transcriptional factor Pho4p may sensitize C. albicans to phosphate limitation. Extensive filamentation was also observed in strain ICU12 suggesting that this strain is also sensitized to phosphate limitation. Analysis of the sequence of PHO4 in strain ICU12, its transcriptional response to phosphate limitation, and phosphatase assays confirmed that ICU12 demonstrates a profound response to phosphate limitation. The emergence of strains of C. albicans with marked responsiveness to phosphate limitation may represent a fitness adaptation to the complex and nutrient scarce environment typical of the gut of a critically ill patient.
Peak to average power ratio reduction for MIMO-OFDM wireless system using nonlinear precoding (2005)

This paper investigates peak-to-average power ratio (PAR) reduction with constrained transmit power for spatially precoded downlink transmission, based on orthogonal frequency-division multiplexing (OFDM). We generalize the concept of multiuser Tomlinson-Harashima (T-H) precoding and propose a nonlinear spatial precoder, termed a complex sphere precoder (CSP), which has the same throughput and error performance as the T-H precoder, but achieves both a low PAR and low average transmit power. Our study shows that a sequential CSP over individual tones achieves a significant PAR reduction while requiring a moderate transmit power increase. The suboptimal per-tone lattice search constitutes a good compromise between performance and complexity.
Pathologic characterization of hypotensive C57BL/6J-agt: angiotensinogen-deficient C57BL/6J mice. (1998)

a fpreviously produced angiotensinogen-deficient mice, i.e. mice with deleted renin-angiotensin system (RAS), with a genetic background on C57BL/6J - C57BL/6J-agt (-/-) -, but no C57BL/6J-agt (-/-) which survived long enough to be weaned. In the present study, we attempted to prevent neonatal death and analyzed pathological development in C57BL/6J-agt (-/-). We indicate that mortality in C57BL/6J-agt (-/-) derived from C57BL/6J-agt (+/-) can be reduced by hypodermic saline injection in the 7 days following birth, that hydronephrosis developed by day 14 in association with polydiplasia and polyuria by day 30, and that chronic hypotension occurs. Hydronephrosis is less damaging to electrolyte resorption in younger mice, but not in adults. We also observed that C57BL/6J-agt (-/-) derived from C57BL/6J-agt (-/-) frequently develop fetal hydronephrosis and die of respiratory failure at birth. These results suggest that maternal RAS is associated with structural maturation of kidney and lung in late fetus and that postnatal RAS plays important roles in structural and functional maintenance of the kidneys.
The Coalinga earthquake sequence commencing May 2, 1983 (Preliminary report on field investigations and data collected as of May 12, 1983) (1983)

8) crustal structure determinations using 100 portable cassette recorders (Walters and others, oral commun.).
Providencia stuartii: A Common Cause of Antibiotic-Resistant Bacteriuria in Patients with Long-Term Indwelling Catheters (1986)

The long-term-catheterized urinary tract may offer a particular niche to Providencia stuartii, which is otherwise an uncommon clinical isolate. Published accounts of bacteriuria in patients catheterized for long periods indicate that P. stuartii has often been found as frequently as familiar uropathogens such as Escherichia coli, Proteus mirabilis, enterococcus, and Pseudomonas aeruginosa. As in most nosocomial infections, the frequency of isolation of a given species has commonly differed among institutions. In the future P. stuartii may be more frequently encountered as a nosocomial pathogen in nursing homes and in acute care hospitals to which bacteriuric patients are transferred. This trend appears likely because of the increasingly large nursing-home population, the predilection of the bacterium for the long-term-catheterized urinary tract, the opportunity for nosocomial transmission from this reservoir, the resistance of the organism to multiple antibiotics, and the occasional systemic illness and bacteremia caused by P. stuartii.
ChemInform Abstract: DERIVATIVES OF BICYCLO(2.2.2)OCTANE‐1,2,3‐TRICARBOXYLIC ACID. ISOMERIZATION DURING OPENING AND CLOSING OF THE N‐PHENYLIMIDE RING (1977)

Abstract Die Verseifung des Imids (I) liefert ein Gemisch etwa gleicher Mengen der Anilide (II) und (III) ( 1 H‐NMR‐Spektren); bei Verseifungen der Imide (IV) und (V) entsteht ausschließlich das Anilid (II).
Effect of Chronic Growth Hormone Treatment on Responses to Epinephrine and Thyrotropin-Releasing Hormone in Lactating Cows (1986)

Bovine growth hormone was administered to four Holstein cows (late lactation) in a Latin square. Treatments were 1) control, subcutaneous injection of placebo, 2) subcutaneous injection of 25 IU growth hormone on alternate days, 3) daily subcutaneous injection of 25 IU growth hormone, and 4) continuous subcutaneous infusion of 25 IU/d growth hormone. Intravenous challenges of epinephrine and thyrotropin-releasing hormone were administered separately on the 1st d after a 12-d interval of growth hormone treatment. Baseline concentrations of nonesterified fatty acids in plasma were not affected by growth hormone treatment. However, release of nonesterified fatty acids to epinephrine challenge was positively related to amount of growth hormone in plasma during treatment and was correlated with milk fat yield and milk energy secretion. Growth hormone release following thyrotropin-releasing hormone was negatively related to amount of growth hormone in plasma during treatment. Release of prolactin to thyrotropin-releasing hormone challenge was not related to average daily dose of exogenous growth hormone. The galactopoeitic action of growth hormone may be partly attributable to its effects on responsiveness of adipose tissue to a lipolytic stimulus but apparently is not associated with changes of pituitary sensitivity to thyrotropin-releasing hormone. Results are consistent with growth hormone functioning as a homeorhetic control of nutrient partitioning.