gebhart/patrepeval huggingface dataset:
SUCCINO- AND PHTHALO-HYDROXAMIC ACIDS (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSUCCINO- AND PHTHALO-HYDROXAMIC ACIDSCHARLES D. HURD, CHARLES M. BUESS, and LUDWIG BAUERCite this: J. Org. Chem. 1954, 19, 7, 1140–1149Publication Date (Print):July 1, 1954Publication History Published online1 May 2002Published inissue 1 July 1954https://pubs.acs.org/doi/10.1021/jo01372a021https://doi.org/10.1021/jo01372a021research-articleACS PublicationsRequest reuse permissionsArticle Views302Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The association of Amyloid P-Component (AP) With The Amyloid Fibril: An updated Method for Amyloid Fibril Protein Isolation (1982)

An amyloid fibril isolation procedure is proposed which uses citrate as well as saline washes to dissociate the calcium dependent linkage of amyloid P-component (AP) from the amyloid fibril. In two amyloid rich tissues, the amount of AP was quantitated in each saline and citrate wash and totalled 13.8% and 20.8% of the amyloid fibrils isolated. The amount of AP removed from these and 22 additional amyloid rich tissues was greater than had previously been recognized. AP protein was present in tissue only when amyloid fibrils were present. It could not be found in normal non-amyloidotic tissue, nor could it be found in tissue sediment after the fibrils were removed.
Waveform Inversion of Reflection Seismic Data for Kinematic Parameters by Local Optimization (1998)

A reformulation of the usual least-squares waveform inversion problem is proposed to retrieve, from seismic data, the kinematic parameters (the two-dimensional (2D) background velocity and the source and cable depth) by local optimization. These last parameters are of paramount importance for a successful inversion of very high resolution (VHR) seismic data which we are interested in. In our inversion the source and cable depth parameters are treated in the same way as the background velocity. To avoid the problem of local minima, a change of unknowns is performed: the depth reflectivity is replaced by its dual variable, called the time reflectivity. In this way, the current value of the reflectivity is stored in the time domain and is strongly decoupled from the current value of the velocity field and cable depth. The increase in modeling complexity (an additional prestackmigration is required for each function evaluation) is compensated by the enlargement of the attraction domain of the global minimum which allows the use of a local optimization technique. A numerical implementation with Born approximation and ray tracing is detailed, in which the derivatives of the travel time are computed via an adjoint state technique for more efficiency. Numerical results illustrate the behavior of the new objective function, and inversion of synthetic and real VHR data for kinematic parameters is performed.
Glycosphingolipids are essential for intestinal endocytic function (2012)

Glycosphingolipids (GSLs) constitute major components of enterocytes and were hypothesized to be potentially important for intestinal epithelial polarization. The enzyme UDP-glucose ceramide glucosyltransferase (Ugcg) catalyzes the initial step of GSL-biosynthesis. Newborn- and adult mice with enterocyte specific genetic deletion of the gene Ugcg were generated. In newborn mutants lacking GSLs at day P0, intestinal epithelia were indistinguishable from those in control littermates displaying an intact polarization with regular brush border. However, those mice were not able to absorb nutritional lipids from milk regularly. Between postnatal days 5 to 7 severe defects in intestinal epithelial differentiation occurred accompanied with impaired intestinal uptake of nutrients. Villi of mutant mice became stunted and enterocytes lacked brush border. The defects observed in mutant mice caused diarrhoea, malabsoption, and early death. In the present study we show that GSLs are essential for enterocyte resorptive function but primarily not for polarization; GSLs are required for intracellular vesicular transport in resorption-active intestine.
Performance based traffic control with IDIPS (2011)

Nowadays Internet is ubiquitous resulting in an increasing path diversity and content duplication. However, while content can be retrieved from many different places, the paths to those places are not equivalent. Indeed, some paths offer better bandwidth while others are less expensive or more stable. In addition, a new range of applications is sensitive to the performance of the paths that carry their traffic. To support this evolution of the Internet, we propose ISP-Driven Informed Path Selection (IDIPS). Any ISP can easily deploy IDIPS to help its customers to select the paths that best meet their requirements in order to reach their content. IDIPS helps in this selection through pro-active measurements and ISP-defined policies. IDIPS is scalable and can support thousands of clients. IDIPS is also flexible and can thus be used by the ISP to optimize its routing decisions to take the performance of its inter-domain links into account.
Packet loss resilient videoconferencing using H.263+ (2002)

Real-time video transmission over the Internet is becoming increasingly desirable for videoconferencing and other interactive applications. The reliable transport protocols used by the Internet were designed mainly for non-real time data, and cannot be used for delay critical applications, which must therefore be able to cope with packet loss. Motion compensated video coding is especially sensitive to loss because of temporal error propagation. In this paper, the effect of packet loss on H.263+ video transmitted using the real-time transport protocol (RIP) is assessed. Various algorithms are described to minimise or prevent temporal error propagation. These algorithms do not rely on retransmissions and do not introduce more than one frame delay, and are therefore suitable for real-time and multicast applications. It is shown that the robustness of H.263+ video can be greatly improved using these techniques. Such techniques can also be applied to other motion compensated video coding standards such as MPEG-4 and H.26L.
Exploiting the addressee's inferential capabilities in presenting mathematical proofs (1997)

Proof presentation systems and, in some more general context, many natural language generation systems suffer from a crucial problem: they present too much information explicitly which the intended audience could more naturally infer from a less detailed text. Moreover, proofs in mathematical textbooks make extensive use of building chains of inferences in specialized notations, which is not sufficiently taken into account by proof presentation systems. Encouraged by these observations, we present a model for presenting mathematical proofs that (1) features the implicit conveyance of information through concise texts, (2) organizes major lines in the proof presentation around focused chains of inferences in a specialized notation, (3) can adapt its output to some of the capabilities of its audience. The methods described in this paper allow us to present proofs of moderately complex size in a quality approaching that of proofs found in mathematical textbooks.
Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis (2009)

Recently, chromogranins were reported to interact specifically with mutant forms of superoxide dismutase that are linked to amyotrophic lateral sclerosis (ALS). This interaction led us to analyze the frequencies of sequence variants of the CHGB gene in ALS patients and matched controls from three different countries. Of particular interest was the finding of the P413L CHGB variant present in 10% of ALS patients (n = 705) as compared to 4.5% in controls (n = 751), conferring a 2.2-fold greater relative risk to develop the disease (P < 0.0001). This effect was mainly contributed by the samples of French origin that yielded a frequency of the P413L variation at 17% in ALS (n = 289) and 5% in controls (n = 448), conferring a 3.3-fold greater risk to develop ALS. Furthermore, the P413L CHGB variant is associated with an earlier age of onset by almost a decade in both sporadic ALS and familial ALS cases. Genetic variation influencing age of onset in ALS had not previously been reported. Expression of fusion CHGB-EGFP constructs in SHSY-5Y cells revealed that the P413L variation can cause defective sorting of CHGB into secretory granules. The finding that CHGB may act as a susceptibility gene and modifier of onset in ALS is consistent with the emerging view that dysfunction of the secretory pathway may contribute to increased vulnerability of motor neurons.
Percutaneous coronary intervention with bivalirudin anticoagulation, immediate sheath removal, and early ambulation: A feasibility study with implications for day‐stay procedures (2002)

We assessed the feasibility and safety of a strategy of transfemoral percutaneous coronary intervention (PCI) with bivalirudin anticoagulation, immediate sheath removal, early ambulation, and, where possible, same-day discharge in 100 consecutive patients. Ambulation was achieved by 2 hr 30 min in 85% of patients and same-day discharge in 26%. PCI was angiographically successful in 97%. In hospital, there were no deaths or Q-wave myocardial infarctions. One patient suffered a non-Q-wave infarction, another in-hospital surgical revascularization and one required blood transfusion for rectal bleeding. Femoral access site hematoma > 5 cm diameter occurred in two patients. In addition, by 1 month there had been one death (at 10 days) and one pseudoaneurysm treated nonsurgically. In this preliminary study, the strategy of bivalirudin bolus anticoagulation, immediate sheath removal, and 2-hr ambulation after PCI appeared safe, with same-day discharge possible in 26% of unselected patients with stable or unstable angina.
Towards Verified Calibrated Radiance Spectra for TELIS (2011)

The balloon borne cryogenic heterodyne spectrometer TELIS allows limb sounding of the Earth's atmosphere within the sub-millimetre and far-infrared spectral range. The instrument was developed by a consortium of major European institutes that includes the Space Research Organisation of the Netherlands (SRON), the Rutherford Appleton Laboratory (RAL) in the United Kingdom and the German Aerospace Center (DLR, lead institute). The instrument offers three channels sensitive within the frequency ranges of 450-650 GHz, 499-503 GHz and 1.790 – 1.870 THz. All receivers utilise state-of-the-art superconducting heterodyne technology. Like all remote sensing instruments, TELIS requires a full characterisation of the instrumental errors. A known error budget in the calibrated radiance spectra is necessary to obtain verified gas concentration profiles. A major characterisation campaign was carried out, utilizing gas cell measurements of OCS and Methanol in order to identify and correct the main error sources. The cell measurements enabled the characterisation of the full instrument under controlled and well known conditions which were kept close to in-flight conditions. Opaque lines with known intensity were recorded at different IF-frequencies. The information obtained from these measurements allowed us to investigate the dominant radiometric error sources of the TELIS instrument caused by non-linearities in the signal chain. The results are merged with results obtained from a former characterisation campaign of the isolated TELIS IF-chain including a reference spectrometer as well as with results obtained from in-flight spectra.
Predicting smokeless tobacco initiation and re-initiation in the United States Air Force (2018)

Our results suggest that initiators may be exploring and viewing ST as a less harmful alternative to cigarette smoking and ST users reporting intentions to use ST in the future often return to use. The development of interventions able to disrupt the link between intentions to use tobacco and future tobacco use in the USAF is vital.
Methods for Improving Long‐Range Wireless Communication between Extreme Terrain Vehicles (2012)

Axel is an extreme terrain, two-wheeled rover designed to traverse rocky surface and sub-surface landscapes in order to conduct remote science experiments in hard-to-reach locations. The rover's design meets many requirements for a mobile research platform capable of reaching water seeps on Martian cliff sides. Axel was developed by the Mobility and Robotic Systems section at the Caltech Jet Propulsion Laboratory. Unique design criteria associated with extreme terrain mobility led to a unique rover solution, consisting of a central module, which provides long-term energy storage and space for large-scale science payloads, and two detachable Axels that can detach and explore extreme terrain locations that are inaccessible to conventional rovers. The envisioned mission could involve a four-wheeled configuration of Axel called 'DuAxel' that is able to traverse the benign, flattened terrain of a landing site and approach the edge of the targeted crater or cave where it would deploy anchoring legs and detach one of the Axel rovers [1]. A tether provides a secure link between the Axel rover and the central module, acting as an anchor to allow Axel to descend along steep crater walls to collect data from the scientifically relevant sites along the water seeps or crater ledges. After completing its scientific mission Axel would hoist itself up to the central module and dock autonomously (using its on-board stereo cameras), allowing the once-again recombined DuAxel to travel to another location to repeat data collection.
A techno‐economic comparison of various process options for the production of 1,1‐diethoxy butane (2012)

Abstract BACKGROUND: Acetals can be considered important bio‐based diesel additives. The production of most of these compounds, from an alcohol and an aldehyde, suffers from low conversion due to thermodynamic limitations. These limitations can be overcome through the removal of the by‐product water. Previous studies showed that the in situ dehydration options of reactive distillation and pervaporation membrane reactor integration offer little advantage or at least not at reasonable unit dimensions. The aim of the present work is the development of a membrane based process and comparison with other alternatives (based on experimental data). RESULTS: Three different membrane processes were developed. The one in which the reaction mixture is recycled over a first dehydration membrane module and subsequently through a simple distillation column, was found to give the highest overall conversion (100%) at low recycle rates and reasonable membrane area. This process was techno‐economically compared with other possible alternatives: (1) a process based on a conventional tubular reactor and several distillation columns; and (2) a process based on reactive distillation. CONCLUSIONS: Efficient water removal by membranes avoids possible azeotropes in downstream distillation units making them much simpler, reducing considerably the unit sizes and the energy demand (40% lower). Copyright © 2012 Society of Chemical Industry
[Significance of the correction of aspirated volumes for the results of the secretin-pancreozymin test (author's transl)]. (1980)

A group of 123 patients without manifestation of an impaired pancreatic function was studied with the secretin-pancreozymin test (group I). In 54 patients (group II) the correction of aspirated volumes during the secretin-pancreozymin test was performed with polyethylene glycol 4000 (PEG) as a marker substance. The mean values of volume-, bicarbonate- and enzyme secretion showed higher levels in 7 of 9 parameters in group II. The recovery rate of polyethylene glycol in group II (median: 92% indicated, why there was no marked difference between both groups. If the secretin-pancreozymin test is performed according to the above method the correction of aspirated volumes becomes negligible for the determination of normal values. However single results of the secretin-pancreozymin test, especially pathological ones, can only be based on the correction of the aspirate.
Observation of induced subcritical bifurcation by near-resonant perturbations (1994)

We present the first experimental evidence that near-resonant perturbations produce a destabilizing shift of a subcritical bifurcation. This is in direct contrast to supercritical bifurcations, where near-resonant perturbations always suppress the instability. Using a normal form analysis we derive a generic scaling law relating the magnitude of the destabilizing shift \ensuremath{\mu} to the perturbation amplitude \ensuremath{\varepsilon} and detuning frequency \ensuremath{\delta}. The predictions are in excellent agreement with our experiments. In the limit of very small \ensuremath{\delta} the shift obeys a pure scaling law, \ensuremath{\mu}\ensuremath{\propto}(\ensuremath{\varepsilon}${)}^{2/3}$.
Chemicopharmacological Studies on Antispasmodic Action. XIV (1958)

Seven isoamyl esters and four diethylaminoethyl esters were synthesized, and their atropine-like and papaverine-like antispasmodic activities were estimated. Isoamyl acetate lacks acetylcholine (ACh)-like action and has some atropine-like and papaveri ne-like anti-ACh actions. These facts shows the indispensability of a cationic center for ACh-like action. The indexes of Ferguson's thermodynamic activity on atropine-like and papaverine-like actions were calculated from the solubility of esters and free bases in water. The isoamyl esters and weak bases such as papaverine have the indexes of a same magnitude and can be interpreted that they act through some physicochemical property of their molecules. The indexes of diethylaminoethyl esters on papaverine-like action were somewhat smaller than the above two groups and ionic state would also be supposed to contribute to papaverine-like action to some extent.
Health‐related quality of life in children with sickle cell anemia: Impact of blood transfusion therapy (2014)

The completion of the Multicenter Silent Infarct Transfusion Trial demonstrated that children with pre-existing silent cerebral infarct and sickle cell anemia (SCA) who received regular blood transfusion therapy had a 58% relative risk reduction of infarct recurrence when compared to observation. However, the total benefit of blood transfusion therapy, as assessed by the parents, was not measured against the burden of monthly blood transfusion therapy. In this planned ancillary study, we tested the hypothesis that a patient centered outcome, health-related quality of life (HRQL), would be greater in participants randomly assigned to the blood transfusion therapy group than the observation group. A total of 89% (175 of 196) of the randomly allocated participants had evaluable entry and exit HRQL evaluations. The increase in Change in Health, measured as the child's health being better, was significantly greater for the transfusion group than the observation group (difference estimate = -0.54, P ≤ 0.001). This study provides the first evidence that children with SCA who received regular blood transfusion therapy felt better and had better overall HRQL than those who did not receive transfusion therapy.
Experimental study of single source-heterojunction MOS transistors (SHOTs) under quasi-ballistic transport (2008)

In this study, we have experimentally demonstrated the high performance of the single source heterojunction MOSFETs (SHOTs) without the energy spike of the drain heterojuction. We have studied the influence of the drain energy spike on the MOSFET performance. Moreover, we have clarified the physical mechanism for the high velocity electron injection in SHOTs, through the lattice temperature dependence of the electron velocity, comparing with that of strained-SOIs (SSOIs).
Decacarbonyldirhenium (2001)

[14285-68-8] C10O10Re2 (MW 652.52) InChI = 1S/10CO.2Re/c10*1-2;; InChIKey = ZIZHEHXAMPQGEK-UHFFFAOYSA-N (oligomerization catalyst) Alternate Name: rhenium carbonyl. Physical Data: mp 177 °C, 170 °C; sublimes 70 °C/0.1 mmHg. Solubility: sparingly sol common org solvents; insol water. Form Supplied in: colorless crystals; commercially available. Handling, Storage, and Precautions: stable to air and to strong acids; may be stored indefinitely at ambient temperature; ignites in air above 140 °C.
(Diphenylphosphino)methanethiol (2007)

[324753-16-4] C13H13PS (MW 232.28) InChI = 1S/C13H13PS/c15-11-14(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2 InChIKey = IGEZSSBBLDNMPJ-UHFFFAOYSA-N (reagent used as coupling reagent in the traceless Staudinger reaction) Solubility: soluble in alcohols, dichloromethane, chloroform, DMF. Form Supplied in: clear oil. Analysis of Reagent Purity: 1H NMR (CDCl3, 300 MHz) δ 7.41–7.38 (m, 4 H), 7.33–7.26 (m, 6 H), 3.02 (d, J = 7.8 Hz, 2 H), 1.38 (t, J = 7.5 Hz, 1 H) ppm; 13C NMR (CDCl3, 75 MHz) δ 132.5 (d, J = 17.1 Hz), 128.8, 128.3, 128.1, 20.6 (d, J = 21.7 Hz) ppm; 31P NMR (CDCl3, 121 MHz) δ −7.94 ppm. Preparative Method: (diphenylphosphino)methanethiol is synthesized from (diphenylphosphino)methyl acetyl sulphide, obtained either by reacting chloromethyldiphenylphosphine oxide with a salt of thioacetic acid1 or by reacting bromomethyl acetyl sulfide with borane–diphenylphosphine complex.2 In a representative example (eq 1), Ar(g) is bubbled through a 153 mM solution of (diphenylphosphino)methyl acetyl sulfide (1 equiv) in anhydrous methanol for 1 h at rt. Then, sodium hydroxide (2 equiv) is added and the mixture is stirred under Ar(g) for 2 h. The solvent is then removed under reduced pressure and the residue is dissolved in CH2Cl2. The resulting solution is washed with 2 N aqueous HCl and brine. The organic layer is dried over MgSO4, filtered, and evaporated to dryness under reduced pressure to afford crude (diphenylphosphino)methanethiol. (1) Purification: by flash chromatography (alumina, 25% ethyl acetate in hexanes). Handling, Storage, and Precautions: the phosphorus atom and to a lesser extent the sulfur atom are highly susceptible to oxidation. The reagent is best stored as a borane-complex intermediate and/or S-acetylated. Deprotection can be performed immediately prior to its use or even in situ during its use.