gebhart/patrepeval huggingface dataset:
Assignment of Weight-Based Antibody Units for 13 Serotypes to a Human Antipneumococcal Standard Reference Serum, Lot 89-S(F) (2004)

Weight-based immunoglobulin G (IgG), IgM, IgA, and total Ig antibody assignments were made to human antipneumococcal standard reference serum lot 89-S, also known as lot 89-SF, for Streptococcus pneumoniae capsular polysaccharide (PnPs) serotypes 2, 6A, 8, 9N, 10A, 11A, 12F, 15B, 19A, 17F, 20, 22F, and 33F, as well as for C-polysaccharide (C-Ps), extending the standard's usefulness for pneumococcal vaccine evaluation beyond the original serotype 1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, and 23F assignments (S. A. Quataert, C. S. Kirch, L. J. Quackenbush Wiedl, D. C. Phipps, S. Strohmeyer, C. O. Cimino, J. Skuse, and D. V. Madore, Clin. Diagn. Lab. Immunol. 2:590-597, 1995). The additional 14 assignments were determined using an equivalence of absorbance method with an anti-PnPs serotype 6B reference enzyme-linked immunosorbent assay (EIA). To assure accuracy, anti-PnPs EIA for serotype 14 antibodies, a previously assigned serotype, was performed concurrently. This method assures consistency of the new microgram-per-microliter assignments with previous antiserotype assignments to lot 89-S. The sum of the experimentally derived isotype assignments for anti-PnPs serotypes in lot 89-S agrees well with the separately determined total Ig assignment for each serotype. The lot 89-S assignments for serotypes 1, 5, 6B, 14, 18C, 19F, and 23F were used for pneumococcal conjugate vaccine clinical trial evaluation and to generate data in efficacy trials where serological correlates for protection have been proposed. The assignment of antibody concentrations to additional pneumococcal serotypes in this reference reagent facilitates the consistent and accurate comparison of serum antibody concentrations across clinical trials.
Binding of TPX2 to Aurora A Alters Substrate and Inhibitor Interactions (2007)

The Aurora kinases are a family of serine/threonine kinases involved in mitosis. The expression of AurA is ubiquitous and cell cycle regulated. It is overexpressed in many tumor types, including breast, colon, and ovarian. TPX2 is a binding partner and activator of AurA. A fragment of TPX2 (residues 1-43) has been shown to be sufficient for binding, kinase activation, and protection from dephosphorylation. We have shown that the addition of TPX2(1-43) increases the catalytic efficiency of AurA. While TPX2 binding has no effect on the turnover number of AurA and does not change the reaction mechanism (characterized here to be a rapid equilibrium random mechanism), it increases the binding affinity of both ATP and a peptide substrate. We have also demonstrated differences in the inhibitor structure-activity relationship (SAR) in the presence or absence of TPX2(1-43). To better understand the differential SAR, we carried out computer modeling studies to gain insight into the effect of TPX2 on the binding interactions between AurA and inhibitors. Our working hypothesis is that TPX2 binding decreases the size and accessibility of a hydrophobic pocket, adjacent to the ATP site, to inhibitors.
Rate Adaptation Mechanism for Multimedia Multicasting in Wireless Networks (2009)

Nowadays, wireless networks have been deploying everywhere, with IEEE 802.11 as the most popular standard. However, wireless resources are scarce and wireless condition varies often. These limitations are crucial for applications with tight QoS requirements such as video or voice over IP. To cope wi
RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System (2017)

CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are RNA-guided adaptive immunity pathways used by bacteria and archaea to defend against phages and plasmids. Type III-A systems use a multisubunit interference complex called Csm, containing Cas proteins and a CRISPR RNA (crRNA) to target cognate nucleic acids. The Csm complex is intriguing in that it mediates RNA-guided targeting of both RNA and transcriptionally active DNA, but the mechanism is not well understood. Here, we overexpressed the five components of the Thermus thermophilus (T. thermophilus) Type III-A Csm complex (TthCsm) with a defined crRNA sequence, and purified intact TthCsm complexes from E. coli cells. The complexes were thermophilic, targeting complementary ssRNA more efficiently at 65°C than at 37°C. Sequence-independent, endonucleolytic cleavage of single-stranded DNA (ssDNA) by TthCsm was triggered by recognition of a complementary ssRNA, and required a lack of complementarity between the first 8 nucleotides (5' tag) of the crRNA and the 3' flanking region of the ssRNA. Mutation of the histidine-aspartate (HD) nuclease domain of the TthCsm subunit, Cas10/Csm1, abolished DNA cleavage. Activation of DNA cleavage was dependent on RNA binding but not cleavage. This leads to a model in which binding of an ssRNA target to the Csm complex would stimulate cleavage of exposed ssDNA in the cell, such as could occur when the RNA polymerase unwinds double-stranded DNA (dsDNA) during transcription. Our findings establish an amenable, thermostable system for more in-depth investigation of the targeting mechanism using structural biology methods, such as cryo-electron microscopy and x-ray crystallography.
Crystal Growth of Na-Co-Doped Ce:LiCaAlF<sub>6</sub> Single Crystals and Their Optical, Scintillation, and Physical Properties (2011)

We have grown Ce- and Na-co-doped LiCaAlF6 (Ce,Na:LiCAF) single crystals with various Ce and Na concentrations by the micro-pulling-down (μ-PD) method. Physical properties such as crystallinity, transmittance, photoluminescence, scintillation, and radiation resistance were investigated to evaluate the effects of charge compensation by Na co-doping in the Ce-doped LiCaAlF6 (Ce:LiCAF) crystal. Ce2%:LiCAF, Ce1%Na1%:LiCAF, Ce1.5%Na1.5%:LiCAF, and Ce2%Na2%:LiCAF crystals with no visible cracks and inclusions were prepared. The Ce1%Na1%:LiCAF crystal showed high crystallinity comparable to the crystal grown by the Czochralski method. In the transmittance and photoluminescence spectra of all crystals, an absorption peak around 270 nm and emission peaks around 285 and 310 nm originating from Ce3+ ions were observed, respectively. With increasing Ce and Na concentrations, the light yield systematically increased, and scintillation decay times decreased. Improvement of radiation resistance accomplished by charge compensation due to Na co-doping is clearly demonstrated.
The CS2 fimbrial antigen from escherichia coli, purification, characterization and partial covalent structure (1985)

The CS2 fimbrial antigen was isolated by salt and isoelectric precipitation and by column chromatography. The purified antigen was free of other fimbrial proteins present on the same bacterial strain. Analysis of the N-terminal amino acid sequence indicated extensive homology with the CFA1 fimbrial antigen, which was surprising since the two proteins do not show any immunological cross reactivity. It could therefore be concluded that the N-terminal parts of these fimbrial proteins are not located on the surfaces of the proteins and might be involved in conservation of the structural integrity of these proteins.
Temperature Dependence of Crystal Structure of the<i>T</i><sub>c</sub>= 51 K Superconductor NdFeAsO<sub>1-<i>y</i></sub>(1-<i>y</i>= 0.85) (2008)

The atomic position of the titled iron-oxypnictide superconductor at various temperatures was determined by Rietveld analysis of synchrotron x-ray diffraction data. Temperature dependence of the crystallographic parameters provides us the following information: (i) significant anisotropic shrinking of the lattice and (ii) the distortion of the FeAs 4 tetrahedron that becomes slightly larger at low temperatures.
A Pore Scale Analysis of Restricted Diffusion in Shale Gas Media (2014)

Molecular diffusion is an important mechanism for hydrocarbons moving from pores to pores and from pores to hydraulic fractures in unconventional shale production. The diffusion coefficient is also an essential parameter in two-dimensional (2D) NMR map interpretations. However, molecular diffusion in the microand nanometer scale pore network of the unconventional shale rock remains poorly understood. The objective of this work is to link the restricted diffusion coefficient to the pore scale characteristics of shale gas media. A random walk algorithm is implemented to investigate the effects of pore-throat ratio (ratio of pore body radius to pore throat radius), length ratio (ratio of throat length to pore radius), pore shape and topology. It is concluded that, at an equal surface-tovolume ratio, the diffusion coefficient increases in pores with higher angularity. The effects of pore-throat ratio and length ratio are explicitly modeled in three dimensional (3D) structured regular lattices. The results indicate that, up to pore-throat ratios of 5, restricted diffusion is considerable in lattices with zero length throats. Furthermore, restricted diffusion decreases with the increase in length ratio. To reduce computational cost, a statistical method was developed to render simulating the effects of connectivity and pore size distribution on 3D unstructured multiscale networks feasible.
Shear resistance of channel shear connectors in plain, reinforced and lightweight concrete (2011)

This paper presents an experimental study on determining shear resistance of channel shear connectors in a solid concrete material slab under monotonic loading. The solid concrete slab is of different types of concrete including plain, reinforced and lightweight concrete. The channel shear connector length is varied as well. A series of push-out specimens were tested for this study. The results verified using channel shear connectors embedded in lightweight concrete in composite structures and shows that lightweight concrete has a slight effect on the ductility and load-displacement performance of the specimens. However, using reinforcement in concrete causes considerable increase in ultimate strength and ductility of channel shear connectors and using channels embedded in unconfined normal concrete has a brittle performance of them. In general, the channel shear connector showed a ductile behaviour.
The immunophilin ligand GPI1046 protects neurons from the lethal effects of the HIV‐1 proteins gp120 and Tat by modulating endoplasmic reticulum calcium load (2006)

The dysfunction and death of neuronal cells is thought to underlie the cognitive manifestations of human immunodeficiency virus (HIV)-associated neurological disorders. Although HIV-infected patients are living longer owing to the effectiveness of anti-retroviral therapies, the number of patients developing neurological disorders is on the rise. Thus, there is an escalating need for effective therapies to preserve cognitive function in HIV-infected patients. Using HIV-protein-induced neurotoxicity as a model system, we tested the effectiveness of a non-immunosuppressive immunophilin ligand to attenuate gp120 and Tat-induced modification of neuronal function. The immunophilin ligand GPI1046 attenuated endoplasmic reticulum (ER) calcium release induced by gp120 and Tat and protected neurons from the lethal effect of these neurotoxic HIV proteins. Both inositol 1,4,5 trisphosphate (IP(3)) and ryanodine-sensitive ER calcium release was attenuated by pre-incubation with GPI1046. Using the sarco/endoplasmic reticulum calcium pump inhibitor thapsigargin to release ER calcium, we determined that GPI1046 reduced the total ER calcium load. These findings suggest that non-immunosuppressive immunophilin ligands may be useful neuroprotective drugs in HIV dementia.
Fermentation Kinetics and Model Processes (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFermentation Kinetics and Model ProcessesFred DeindoerferCite this: Ind. Eng. Chem. 1960, 52, 1, 63–64Publication Date (Print):January 1, 1960Publication History Published online1 May 2002Published inissue 1 January 1960https://pubs.acs.org/doi/10.1021/ie50601a044https://doi.org/10.1021/ie50601a044research-articleACS PublicationsRequest reuse permissionsArticle Views776Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A cinchonidine derivative for photoaffinity labelling of proteins (2000)

8-Aminohydrocinchonidine was prepared and coupled with 4-azidosalicyclic acid. The resulting amide was labelled with 125I to produce a photoactivatable species for attaching to proteins. Copyright © 2000 John Wiley & Sons, Ltd.
Soliton based DPSK encoded sequences: Stability and dynamical properties (2010)

We study the dynamical properties of the RZ-DPSK encoded sequences of bits, focusing on the instabilities in the train leading to the bit stream corruption. The problem is studied within the framework of the complex Toda chain model for optical solitons. We show how the bit composition of the pattern affects the initial stage of the train dynamics and explain the general mechanisms of the appearance of unstable collective soliton modes. Then we discuss the nonlinear regime using the asymptotic properties of the pulse stream at large propagation distances and analyze the dynamical behavior of the train elucidating different scenarios for the pattern instabilities.
Portus. Possible Mithraeum (2019)

Deux inscriptions retrouvées durant les fouilles menées par les Torlonia dans les années 1860 témoignent de la présence du culte de Mithra à Portus (Floriani Squarciapino 1962, 57-58). La première est un album d’initiés, la seconde, une dédicace accompagnant un décor mithriaque en relief sur un vase. Il est donc très vraisemblable qu’un mithraeum au moins ait été implanté à Portus. Sources épigraphiques CIL XIV, 286 ; IPOstie B, 295 ; CIMRM I, 325 ; Marchesini 2012-2013, 324-328 ; EDR144064 (...
<i>In situ</i> investigation of vapor-deposited glasses of toluene and ethylbenzene via alternating current chip-nanocalorimetry (2013)

Vapor-deposited glasses of toluene and ethylbenzene have been characterized by in situ ac chip-nanocalorimetry. The high sensitivity of this method allows the detection of small changes in the heat capacity of nanogram size samples. We observe that vapor-deposited glasses have up to 4% lower heat capacities than the ordinary glass. The largest heat capacity decrease and the most kinetically stable glasses of toluene and ethylbenzene are observed in a range of deposition temperatures between 0.75 T(g) and 0.96 T(g). Compared to larger molecules, deposition rate has a minor influence on the kinetic stability of these glasses. For both toluene and ethylbenzene, the kinetic stability is strongly correlated with the heat capacity decrease for deposition temperatures above 0.8 T(g). In addition, ac-nanocalorimetry was used to follow the isothermal transformation of the stable glasses into the supercooled liquid at temperatures slightly above T(g). Toluene and ethylbenzene stable glasses exhibit a constant transformation rate which is consistent with the growth front mechanism recently demonstrated for tris-naphthylbenzene and indomethacin. The kinetic stability of the most stable toluene and ethylbenzene glasses is comparable to that observed for other stable glasses formed by vapor deposition.
Novel interferometer to measure the figure of strongly aspherical mirrors (2001)

Mid-spatial frequenciesAs mentioned above, the small-angle scatter caused by mid-spatial frequency ripple leads to smearing out the image core and thus to a reduction of the resolution.This scatter is sometimes called flare, which is defined as the level of scattered light in an otherwise dark region.First, we will determine the spatial frequency range of these mid-spatial frequency ripples.Subsequently, we will specify the allowable rms surface height error within this range.In accordance with the definition of flare, we take the lower limit of the midspatial frequency range as the spatial frequency at which surface height variations scatter light just outside the circle on which 99% of the energy falls, i.e. the spa- Definitions of the surface figure error and the rms surface figure errorAs explained in the previous section, the spatial frequency range within which the novel instrument determines the rms surface height error and the spatial frequency range within which it measures the surface height error itself, stretch from F -1 to 1 mm -1 .Therefore, we introduce a new function g a (x, y), referred to A A g m RMS g a RMS g a RMS g a RMS ' PDF RMS g m g a RMS PDF RMS g a g m RMS g m RMS
Single-electronics And Molecular Electronics (2005)

The recently discovered effect of the correlated single-electron tunneling enables one to control transfer of discrete electrons along systems of small conducting particles separated by tunnel barriers. This control can be used, in particular, for processing of digital information encoded by single electrons. In this report I will review recent depelopment of a new scientific field , the ttsingle-electronics , based on this effect, and discuss a possibility to use it for the digital information processing on the molecular level.
Independent and Simultaneous Delay Control of Two 10-Gb/s Channels Using a Single Optical Delay Element (2009)

We demonstrate a single tunable delay element based on wavelength conversion and dispersion for independent dual-channel operation. The two signals are sent bidirectionally to a single piece of highly nonlinear fiber for wavelength conversion by four-wave mixing. The converted signals are then sent to a chirped fiber Bragg grating to utilize its wavelength-dependent delay characteristic. We demonstrate up to 400-ps delay for return-to-zero and nonreturn-to-zero modulated signals at 10 Gb/s. The amount of delay for each channel is controlled by the wavelength of a pump signal, and is completely independent of the presence of the other one. The quality of the delayed signals is also independent of the presence of the other; this is verified by bit-error-rate measurements.
Adaptive eigensubspace algorithms for direction or frequency estimation and tracking (1988)

The authors present an adaptive estimator of the complete noise or signal subspace of a sample covariance matrix as well as the estimator's practical implementations. The general formulation of the proposed estimator results from an asymptotic argument, which shows the signal or noise subspace computation to be equivalent to a constrained gradient search procedure. A highly parallel algorithm, denoted the inflation method, is introduced for the estimation of the noise subspace. The simulation results of these adaptive estimators show that the adaptive subspace algorithms perform substantially better than P.A. Thompson's (1980) adaptive version of V.F. Pisarenko's technique (1973) in estimating frequencies or directions of arrival (DOA) of plane waves. For tracking nonstationary parameters, the simulation results also show that the adaptive subspace algorithms are better than direct eigendecomposition methods for which computational complexity is much higher than the adaptive versions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Distributed photovoltaic system impact upon utility load/supply management practices (1984)

Presentation d'une methode de simulation de l'impact economique et de fiabilite sur un reseau electrique de l'integration de systemes photovoltaiques disperses. Resultats obtenus pour differents scenarios de penetration
Evaluation of polarization mode coupling coefficient from measurement of polarization mode dispersion (1985)

Polarization mode coupling coefficient is evaluated from the measurement of polarization mode dispersion as a function of fiber length in a single-mode fiber having an elliptical-core with 10-percent ellipticity. The modal dispersion measurement are carried out by the improved spatial technique based on an optical heterodyne detection at the wavelengths of 0.85 and 1.3 μm. The coupling coefficients are evaluated from the measurements to be <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3.4 \times 10^{-3}</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4.6 \times 10^{-3}</tex> m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> for modal-birefringence magnitudes of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8 \times 10^{-6}</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3 \times 10^{-6}</tex> , respectively. The coupling coefficients obtained from the dispersion measurement are coincident with those evaluated from the extinction-ratio measurements. In addition, dependence of the coupling coefficient on propagation constant difference between the two orthogonally polarized HE <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</inf> modes is investigated based on Lorentzian power spectrum model.
How to achieve cost-effective sintering (1990)

Conveyor belt sintering furnaces presently used in iron powder metallurgy (PM) are classified, compared and contrasted according to their design features. If furnaces vary in their design but have comparable output capacities, the consumption of power, atmosphere gases, etc. as well as the finite operating cost per kilogram of sintered product are discussed. It is shown that the lowest operating cost is achieved by using conveyor belt furnaces which incorporate de-waxing zones which are heated by the protective gas issuing from the electrically heated sintering zone, the protective gas itself being produced by catalytic generation within the body of the furnace.
Atopic Ocular Surface Disease (2005)

Ocular surface inflammation, tear film instability, and decreased conjunctival MUC5AC mRNA expression are important in the pathogenesis of noninfectious corneal shield ulcers in atopic ocular surface disease.
Familientherapie (2000)

Zusammenfassung Es gibt viele Gründe, warum Familienmitglieder aneinander leiden können, ein Familienmitglied deswegen sogar psychisch krank werden kann bzw. es ihm schwer fällt, seine seelische Störung zu bewältigen. Es gibt aber auch viele Gründe dafür, warum Familienmitglieder sich gegenseitig stärken können, die Familie als emotionaler Schutzschild für jeden einzelnen und auch für das gesamte System der Familie genutzt werden kann.