gebhart/patrepeval huggingface dataset:
Anticoagulant Therapy—1974 (1974)

THE national impact of thrombosis should not be underestimated. Arterial thromboembolism is a major, if not the primary, contributor to the number 1 (acute myocardial infarction), number 3 (stroke), and the number 4 (renal) causes of death in the United States. In addition, thromboembolic episodes are frequently associated (either causally or as a complication) with rheumatic or atherosclerotic valvular diseases, arrythmias, congestive heart failure, and intimal damage in the carotid artery, the aorta-iliac region, and the arteries of the lower extremities. Some infections and severe blood dyscrasias also may be associated with arterial thrombosis. Venous thromboembolism causes approximately 300,000 patients annually to be hospitalized in the United States, of which more than 50,000 die. The cost of the hospitalization of the 250,000 survivors has been calculated to be approximately $750 million per year. These figures do not include the morbidity and cost for patients with venous thrombosis alone, nor the
<title>Remote electrically passive position transducer</title> (1999)

We will report on the design and testing of a precision, remote, via fiber optics position transducer suitable for incorporation in a closed loop fly-by-light positioning system. The design is based on Visidyne developed technology for an ultra high resolution optical radar based on Continuous Wave modulated light at a frequency of 1 GHz. It produces digital position data with 12 bit precision e.g., for a travel distance, stroke of 6 inches or greater at a bandwidth, update rate of 1 KHz. The passive nature of the transducer at the actuator location and the high operating frequency makes it highly tolerant to even extreme levels of Electro Magnetic Interference and when constructed from high temperature material is can operate at temperatures well in excess of 300 degrees C. We will discuss transducer performance, precision and position stability with particular emphasis on the effects of length changes within the multi-mode optical fibers used to deliver and collect the light to and from the transducer. We will also discuss cost aspects of the design and their effect on overcoming market entry barriers.
Infrared Study of Arylazopyrazolone Compounds and Their Copper Derivatives (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfrared Study of Arylazopyrazolone Compounds and Their Copper DerivativesFRED A. SNAVELY, WALTER S. TRAHANOVSKY, and FRED H. SUYDAMCite this: J. Org. Chem. 1962, 27, 3, 994–997Publication Date (Print):March 1, 1962Publication History Published online1 May 2002Published inissue 1 March 1962https://pubs.acs.org/doi/10.1021/jo01050a074https://doi.org/10.1021/jo01050a074research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of the photooxidations of 1,5-dithiacyclooctane, 1,4-dithiane, and pentamethylene sulfide. Another example of remote participation during photooxidation at sulfur? (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of the photooxidations of 1,5-dithiacyclooctane, 1,4-dithiane, and pentamethylene sulfide. Another example of remote participation during photooxidation at sulfur?Edward L. Clennan, Dao Xin Wang, Kang Yang, Derek J. Hodgson, and Aderemi R. OkiCite this: J. Am. Chem. Soc. 1992, 114, 8, 3021–3027Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/ja00034a039https://doi.org/10.1021/ja00034a039research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Computational modeling of apoptotic signaling pathways induced by cisplatin (2012)

Using this model, we revealed a novel mechanism by which cisplatin induces dose-dependent cell death. Our finding that the level of apoptosis was affected by not only cisplatin concentration, but also by cross talk among pathways provides in silico evidence for a functional impact of system-level characteristics of signaling pathways on apoptosis.
Micromachined Packaging for Terahertz Systems (2017)

Micromachined packaging is emerging as the best choice for development of terahertz multipixel heterodyne array instruments and other advanced terahertz systems. Traditional computer numerically controlled (CNC) metal machining can still be used for component and simple single-pixel receiver fabrication but falls short when highly compact and integrated systems are needed. Several micromachining methods have shown potential at these frequencies with permanent thick-resists, thick-resist electroforming and deep reactive ion etching (DRIE) of silicon micromachining are discussed in detail. These techniques use photolithographic techniques to produce features accurate to 3 μm or less. Silicon micromachining and electroforming offers the additional advantage of vertical stacking of components, enabling higher circuit densities for these waveguide-based components. To demonstrate these capabilities several integrated systems are discussed.
Finding Optimal-Path Maps for Path Planning across Weighted Regions (2000)

Optimal-path maps tell robots or people the best way to reach a goal point from anywhere in a known terrain area, eliminating most of the need to plan during travel. The authors address the construction of optimal-path maps for two-dimensional polygonal weighted-region terrain, terrain partitioned into polygonal areas such that the cost per unit of distance traveled is homogeneous and isotropic within each area. This is useful for overland route planning across varied ground surfaces and vegetation. The authors propose a new algorithm that recursively partitions terrain into regions of similar optimal-path behavior, and defines corresponding “path subspaces” for these regions. This process constructs a piecewise-smooth function of terrain position whose gradient direction is everywhere the optimal-path direction, permitting quick path finding. The algorithm used is more complicated than the current path-caching and wavefront-propagation algorithms, but it gives more accurate maps requiring less space to represent. Experiments with an implementation confirm the practicality of the authors’ algorithm.
From opacity to transparency via translucent optical networks (2008)

A collection of slides from the author's conference presentation is given.
Laboratory diagnosis of human disease caused by H5N1 influenza virus (2006)

Also published in Newsletter of The Hong Kong College of Pathologists, 2006, v. 15 n. 1, p. 4-7 : http://www.hkcpath.org/article/year-2006
The influence of the harmonics on the temperature of electrical Machines (2005)

In this paper, we study the temperature rise in an asynchronous motor with nonsinusoidal voltage feeding. The stator and rotor current harmonics are calculated using a time step method. Inverse problem techniques are used to evaluate the homogenized electromagnetic and thermal characteristics of the stator windings. Temperatures in sinusoidal approximation and harmonic currents are compared with experimental measurements.
Waiting Before Birth: Outcomes After Fetal Listing for Heart Transplantation (2008)

Following fetal diagnosis of a profound heart defect, transplantation (HTx) is an alternative to pregnancy termination or neonatal surgical palliation. Retrospective review of the cardiac and transplant databases of fetal listings for HTx between 1990 and July 2006 was undertaken to describe outcomes after listing. We identified 26 fetal listings (of 269 total listings). Diagnoses included congenital heart disease (n = 24) and cardiomyopathy (n = 2). Seven patients were delisted after birth: in five cases parents opted for surgical palliation, two clinically improved. One patient died wait-listed (stillborn). Time wait-listed as a fetus ranged from 1-41 days (median 19 days). Eighteen patients underwent HTx (median weight 2.8 kg, range 2.1-10.9 kg); median days wait-listed after birth was 22 (4 h-123 days). Two fetuses were surgically delivered at 36 weeks gestation when a donor organ became available; 11 were transplanted as neonates (<30 days). The median age at HTx was 1 month (4 h-2.6 months). Fetal listing for HTx increases the potential window of opportunity for a donor organ to become available; patients had low wait-list mortality and a fair intermediate-term outcome. Well-defined criteria for eligibility for fetal listing and priority allocation to infants over fetuses seem rational approaches for centers that offer fetal listing.
Functional Analysis of a Centromere from Fission Yeast: A Role for Centromere-Specific Repeated DNA Sequences (1990)

A circular minichromosome carrying functional centromere sequences (cen2) from Schizosaccharomyces pombe chromosome II behaves as a stable, independent genetic linkage group in S. pombe. The cen2 region was found to be organized into four large tandemly repeated sequence units which span over 80 kilobase pairs (kb) of untranscribed DNA. Two of these units occurred in a 31-kb inverted repeat that flanked a 7-kb central core of nonhomology. The inverted repeat region had centromere function, but neither the central core alone nor one arm of the inverted repeat was functional. Deletion of a portion of the repeated sequences that flank the central core had no effect on mitotic segregation functions or on meiotic segregation of a minichromosome to two of the four haploid progeny, but drastically impaired centromere-mediated maintenance of sister chromatid attachment in meiosis I. This requirement for centromere-specific repeated sequences could not be satisfied by introduction of random DNA sequences. These observations suggest a function for the heterochromatic repeated DNA sequences found in the centromere regions of higher eucaryotes.
ANÁLISE DA VARIABILIDADE DA FREQUÊNCIA CARDÍACA EM ATLETAS DE JUDÔ (2013)

Introducao: A Variabilidade da Frequencia Cardiaca e considerada como uma das mais eficientes avaliacoes do sistema autonomico na regulacao da atividade cardiaca. Fisiologicamente, a capacidade de variar a frequencia cardiaca e adaptar o funcionamento do sistema cardiovascular a diferentes necessidades e de extrema importância para o funcionamento adequado do organismo. Objetivo: O principal objetivo e de avaliar a variabilidade da frequencia cardiaca nos dois grupos experimentais e verificar se o grupo de individuos treinados apresenta maior variabilidade em relacao aos individuos sedentarios. Metodologia: A amostra foi constituida por 2 grupos compostos cada um por 7 individuos jovens e saudaveis, sendo: Grupo 1 – formado por individuos sedentarios, de idade media  de 28± 3 anos; Grupo 2 – formado por atletas da equipe de judo, de idade media  de 23± 3 anos. A Variabilidade da Frequencia Cardiaca foi analisada em teste de esforco, utilizando o Protocolo de Bruce, monitorada por ECG computadorizado atraves de 12 derivacoes padrao.  Os intervalos R-R obtidos foram agrupados em periodos de 1 minuto e analisados por calculos estatisticos de media e desvio padrao. Resultados: Alem de constatar a diferenca entre a Variabilidade da Frequencia Cardiaca entre os grupos, foi possivel analisar a atuacao dos sistemas simpatico e parassimpatico durante o teste e pos exercicio. A analise no periodo de recuperacao confirma resultados ate entao possiveis apenas pela analise espectral.. Conclusao: A impressao comum a todos os investigadores dessa area e que as flutuacoes do ritmo cardiaco ocorrem da interacao entre o sistema nervoso simpatico e parassimpatico na atividade intrinseca do no sinoatrial.. Palavras chave: variabilidade de frequencia cardiaca, intervalo R-R, sistema nervoso autonomo e condicionamento fisico.
An End-to-End Approach to the Resequencing Problem (1984)

The resequencing or serialization problem is of basic interest in distributed systems and computer communication systems. This is because a flow of packets, messages, or updates entering a communication system in chronological order from the same port or from different ports may be disordered. The receiving port must then ensure that these objects are resequenced in the appropriate order before they are fed to the output of the system. In this paper we analyze the end-to-end delay recurred by objects traversing such a system, including the d~sordering delay, the delay introduced by the resequencing algorithm, and the delay due to the output server at the receiving port. The analysis is carded out via factorization methods.
Electrical Control of Optical Plasmon Resonance with Graphene (2013)

Despite unique and fascinating capability in subwavelength optics, active control of optical plasmon resonance has been hampered by drastically weak optical response of free carriers at optical frequency. We demonstrate efficient control of optical plasmon resonance in gold nanorod with graphene by electrical gating.
Directional acoustic startle response in the goldfish (1998)

Fish exhibit a characteristic Mauthner-initiated startle response to sudden acoustic stimuli. This escape response is thought to be triggered by predatory attacks since an acoustic wave is launched ahead of a striking predator. The nature of acoustic stimuli which elicit the startle response was examined in free-swimming goldfish (Carassius auratus). The results showed that a threshold level of acoustic acceleration (−30 dB re: 1 m/s2), not pressure, was required to elicit a startle and that the threshold was invariant of bearing to the source. Near threshold, the fish turned in a random direction, but as the stimulus level increased, the fish was more likely to turn away from the source. The data indicated that the lateral component of the acoustic acceleration was the relevant parameter determining directionality. A proposed model uses the utricle to detect acoustic acceleration directly, the saccule to detect acoustic pressure indirectly, and logical wiring to perform the neural computation which explains the fish’s behavioral performance.
ManifoldBoost (2008)

We describe a manifold learning framewor that naturally accommodates supervised learning, partially supervised learning and unsupervised clustering as particular cases. Our method chooses a function by minimizing loss subject to a manifold regularization penalty. This augmented cost is minimized using a greedy, stagewise, functional minimization procedure, as in Gradientboost. Each stage of boosting is fast and efficient. We demonstrate our approach using both radial basis function approximations and trees. The performance of our method is at the state of the art on many standard semi-supervised learning benchmarks, and we produce results for large scale datasets.
Inactivation of Nuclear Factor κB by Soy Isoflavone Genistein Contributes to Increased Apoptosis Induced by Chemotherapeutic Agents in Human Cancer Cells (2005)

Cancer chemotherapeutic strategies commonly require multiple agents. However, use of multiple agents contributes to added toxicity resulting in poor treatment outcome. Thus, combination chemotherapy must be optimized to increase tumor response and at the same time lower its toxicity. Chemotherapeutic agents are known to induce nuclear factor kappaB (NF-kappaB) activity in tumor cells, resulting in lower cell killing and drug resistance. In contrast, genistein has been shown to inhibit the activity of NF-kappaB and the growth of various cancer cells without causing systemic toxicity. We therefore investigated whether the inactivation of NF-kappaB by genistein before treatment of various cancer cells with chemotherapeutic agents could lead to better tumor cell killing as tested by in vitro studies using gene transfections and also by animal studies. PC-3 (prostate), MDA-MB-231 (breast), H460 (lung), and BxPC-3 (pancreas) cancer cells were pretreated with 15 to 30 micromol/L genistein for 24 hours and then exposed to low doses of chemotherapeutic agents for an additional 48 to 72 hours. We found that 15 to 30 micromol/L genistein combined with 100 to 500 nmol/L cisplatin, 0.5 to 2 nmol/L docetaxel, or 50 ng/mL doxorubicin resulted in significantly greater inhibition of cell growth and induction of apoptosis compared with either agent alone. Moreover, we found that the NF-kappaB activity was significantly increased within 2 hours of cisplatin and docetaxel treatment and that the NF-kappaB inducing activity of these agents was completely abrogated in cells pretreated with genistein. These results were also supported, for the first time, by animal experiments, p65 cDNA transfection and p65 small interfering RNA studies, which clearly showed that a specific target (NF-kappaB) was affected in vivo. Collectively, our results clearly suggest that genistein pretreatment inactivates NF-kappaB and may contribute to increased growth inhibition and apoptosis induced by cisplatin, docetaxel, and doxorubicin in prostate, breast, lung, and pancreatic cancer cells. Theses results warrant carefully designed clinical studies investigating the combination of soy isoflavones and commonly used chemotherapeutic agents for the treatment of human cancers.
Plasma-Surface Interactions in Controlled Fusion Devices (Report on the 4th International Conference, Garmisch-Partenkirchen, 1980) (1980)

In controlled fusion devices, especially tokamaks, hydrogen from the walls is a major particle input to the plasma and losses to the wall and limiters/divertors are the major sink for particles. Most of the impurities come from walls or limiters as the direct result of plasma-surface interactions. Divertors modify the path for plasma-surface interactions and increase our control over them, but do not eliminate them. The search for understanding and for control of these plasma-surface interactions brought 200 scientists from twenty countries to this international conference on plasma-surface effects in controlled fusion devices. 140 papers were presented in 14 sessions.
Magnetization transfer contrast: method for improving contrast in gradient-recalled-echo images. (1991)

A method that improves contrast in gradient-recalled-echo magnetic resonance images is described. The increase in contrast is produced by applying low-power radio-frequency irradiation 5-10 kHz from the main water proton resonance frequency to excite macromolecular hydrogen-1 nuclei as part of a conventional gradient-recalled-echo sequence. The contrast so obtained is theoretically different from T1 or T2 contrast and has been termed magnetization transfer contrast. Cat head images were acquired in vivo with this method at 4.7 and 1.5 T. Compared with conventional gradient-recalled-echo images, the magnetization transfer images demonstrate increased contrast between many tissue pairs, such as between white matter and blood and between gray matter and cerebrospinal fluid. The dependence of the magnetization transfer effect on repetition time and preirradiation power were also studied.
<b>ACYLPOLYAMINES MIMIC THE ACTION OF JORO SPIDER TOXIN (JSTX) ON CRUSTACEAN MUSCLE GLUTAMATE </b><b>RECEPTORS </b> (1989)

Effects of 10 synthetic compounds structurally related to spider toxins were studied on the glutamate receptors in crustacean neuromuscular synapses. The asparaginyl cadaverine moiety located in the middle part of JSTX-3 molecule is found to be unnecessary for the activity, since the aromatic or aliphatic part attached directly to the terminal amino group of spermine through an amido-bond mimics-the blocking action of J STX-3 on the lobster neuromuscular synapse. All such synthetic compounds are active to varying extents and recovery from the inhibitory action could be achieved by washing the preparation. The most potent synthetic compound was 1-naphthylacetyl spermine (approximately 1/ 10 of JSTX-3) which may be useful as a probe for studies on this type of glutamate receptor.
Green Separation Science and Technology: Replacement of Volatile Organic Compounds in Industrial Scale Liquid-Liquid or Chromatographic Separations (2000)

One area of opportunity for new chemical science and engineering technology which will help meet the goals of the U.S. Chemical Industry's Technology Vision 2020 is the development of new separations technologies that eliminate the use of flammable, toxic VOCs as industrial solvents. Alternative technologies currently under investigation in our laboratories include those based on the use of water soluble polyethylene glycol polymers in either liquid/liquid (aqueous biphasic systems - ABS) or chromatographic (aqueous biphasic extraction chromatographic resins - ABEC) separations, and those based on air and moisture stable, water immiscible room temperature ionic liquids (RTIL). The ABS and ABEC applications are highlighted with two patented technologies for pertechnetate separation including: a) applications in radiopharmacy where the use of cleaner neutron-irradiated isotopes rather than fission-produced isotopes is possible, and b) applications in nuclear waste remediation where reduction of secondary waste streams produced by conventional technologies are anticipated. The potential and challenges for using the much less studied RTIL in novel separations will also be discussed. Within a new paradigm of pollution prevention and with industry participation, it is anticipated that a tool-box approach to Green Separation Science & Technology will lead to new technologies which do not utilize VOCs.