gebhart/patrepeval huggingface dataset:
Filipin as a cholesterol probe. II. Filipin-cholesterol interaction in red blood cell membranes. (1984)

Filipin, a mixture of polyene antibiotics which form complexes with cholesterol, perturbs membrane lipid organization, and causes hemolysis of erythrocytes, is increasingly used as a cytochemical probe for the distribution of cholesterol in cell membranes. We used light (phase-contrast, dark-field and fluorescence) and electron microscopical techniques (whole-mount shadowing, negative staining, and freeze-fracture) to study the interaction of filipin with unfixed and glutaraldehyde-fixed human red blood cell (RBC) membranes. Lysis time and extent depended upon the cholesterol:filipin (C:F) ratio. Lysis was prevented by osmotic protection with high MW dextran. Filipin treated cells fluoresced, but variation in fluorescence intensity among unfixed as well as among fixed cells was evident both at low and high C:F ratios. Negatively stained preparations of unfixed cells lysed on grids or in suspension revealed ring- or C-shaped filipin-induced lesions (FIL) equipped with a veil-like appendage; single FIL, and FIL fused by their veils into aggregates, were shed from membranes. FIL at the surface proper of shadowed whole-mounts and of freeze-etched preparations of prefixed cells appeared as single, dispersed or aggregated cylinders protruding to variable heights above the membrane's plane; aggregated FIL were shed from cells. The freeze-fracture appearance of FIL differed in membranes fixed before or after filipin treatment. E- and P-faces of post-fixed membranes exhibited cylindrical protrusions and depressions, respectively; in essence, the reverse was found in pre-fixed RBC. Both pre- and post-fixed membranes showed considerable variation in the number of FIL on individual cells whether incubated at high (1:1) or low (1:5) C:F ratios, or for a short (10 min) or a long (80-180 min) time. Aggregation and shedding of FIL was evident in all preparations. Thin layer chromatography of the incubation fluid after sedimentation of cells showed that membrane cholesterol was shed from incubated cells. The presented data question the feasibility of filipin as a probe for the topographical distribution of cholesterol in cell membranes.
Mobile image search with multimodal context-aware queries (2010)

The proliferation of camera-equipped mobile devices with enhanced mobile computing power and network connectivity results in a rising demand for mobile image search. Although image search has been studied extensively over the last few decades, most existing solutions are based on and optimized for desktop and server platforms, not for mobile devices. In this paper, we address some of the challenging issues unique in mobile search scenarios and suggest a list of potential solutions. As a case study, we design a mobile landmark image search system to evaluate the effectiveness of some proposed solutions. To enhance the mobile search experience, we propose a multimodal search scheme which uses both image content and user location to increase search precision and thus minimize network usage. We also suggest a post-search result pruning method designed to match the most relevant results to a user's search interests. Experiments conducted on our Landmark-450 image dataset demonstrate that the proposed methods can significantly increase the relevance of selected results in response to mobile image search while also reducing the amount of data transferred across the network.
Identification and Recovery of the Blurred QR Code Image (2012)

This paper describes the basic information of QR Code. Especially for the blurred QR Code image, we put forward an improved NAS-RIF algorithm which makes bimodal characteristic of the barcode image into it as a constraint. NAS-RIF algorithm itself has a good convergence speed. It will effectively improve the recovery effect of barcode image after combining with bimodal limit. The experiment shows that the improved algorithm not only enhances PSNR but improves the visual effect of the restored barcode image.
Biometrics Authentication With Smartcard (2002)

The purpose of this paper is to highlight and solve issues concerning the biometric information for authentication and their use with smartcards.
Separation Test of Ilmenite in Yunnan (2014)

Because of the low ilmenite grade and fine dissemination size, a lot of low-magnetic flaky phlogopite in the run-of-mine ore and it can not effectively remove the phlogopite by the high gradient magnetic separation, so it is very difficult to sorting. We decided take the process of low intensity magnetic separation – high gradient magnetic separation and gravity separation discarding tailing - high gradient magnetic separation and shaking concentrate. Then we obtained satisfaction index - the grade and the recovery of TiO 2 were 43.32% and 74.41% in the ilmenite concentrates, the grade and recovery of Fe were 66.83% and 56.77% in the iron concentrates. It provides a feasible way for such ilmenite separation.
Secure machine‐type communications in LTE networks (2015)

Abstract With a great variety of potential applications, machine‐type communications (MTC) is gaining a tremendous interest from mobile network operators and research groups. MTC is standardized by the 3rd Generation Partnership Project (3GPP), which has been regarded as the promising solution facilitating machine‐to‐machine communications. In the latest standard, 3GPP proposes a novel architecture for MTC, in which the MTC server is located outside the operator domain. However, the connection between the 3GPP core network and MTC server in this scenario is insecure; consequently, there are distrustful relationships among MTC device, core network, and MTC server. If the security issue is not well addressed, all applications involved in MTC cannot be put into the market. To address this problem, we propose an end‐to‐end security scheme for MTC based on the proxy‐signature technique, called E 2 S E C . Specifically, both the MTC device and MTC server can establish strong trustful relationships with each other by using the proxy signatures issued by the 3GPP core network. Moreover, we present some implementation considerations of E 2 S E C and analyze the performance during authentication by comparing the operational cost of three cases that apply three different signature algorithms, that is, ElGamal, Schnorr, and DSA. Through security analysis by using Automatic Cryptographic Protocol Verifier (ProVerif), we conclude that the proposed E 2 S E C scheme can achieve the security goals and prevent various security threats. Copyright © 2015 John Wiley & Sons, Ltd.
Real time strain imaging and in-vivo applications in prostate cancer (2002)

Prostate tumors can have a higher mechanical hardness than the surrounding tissue. During the digital rectal exam this can be used not only to detect the hypertrophy but also localized hardenings. The examination by digital palpation is inaccurate and even in combination with PSA-value and a transrectal ultrasonic examination the result is often not reliable. Ultrasound strain imaging is able to measure and visualize the elastic properties of a tissue region and hence is an adequate supplement for commonly used diagnostic procedures. We have developed a real time system for elastographic mechanical tissue assessment of the prostate which can be used for the transrectal ultrasonic examination for navigation and diagnosis. During the examination a sequence of ultrasonic images is acquired while the organ is slightly compressed by the ultrasound probe. Using a numerical analysis of image pairs of the acquired sequence the tissue strain is calculated which represents the spatial elasticity distribution of a specific cross-section of the organ and which are able to distinguish hard areas in the tissue. We present results from several patients which show that real time strain imaging is able to detect tumor-like areas which are inconspicuous in the b-mode image. The results correspond to the histological specimens. After the evaluation of 170 patients using a prospective study we found the specificity for cancer detection to be approximately 84% and a sensitivity of approximately 76%. Furthermore the tumor location and extend was correctly predicted in most of the investigated patients using our real time strain imaging.
The Application of Multi-sensor Information Fusion by Improved Trust Degree on SLAM (2013)

This paper presents a novel multi-sensor information fusion method by improved trust degree for Simultaneous Localization and Mapping (SLAM) on segment-Based maps. The nearest neighbor method is utilized to detect homologous features, and a fuzzy-index belief function is defined to obtain correlation of features detected by various sensors. Then, an objective weight of sensor data Based on trust degree is designed. The paper combines an objective weight with an expert weight to be a fusion weight for acquiring accurate environment features. Finally, Extended Kalman Filter (EKF) is adopted to update robot pose and map. The experimental results show that the algorithm can highly improve the precision of the robot pose and the map.
Effects of the low loss polymers on the dielectric behavior of novel aluminum-filled high-k nano-composites (2004)

Passive components, active components, and interconnecting substrates are the fundamental building blocks for an electronic system, and nowadays, a large percentage of the printed circuit board (PCB) surface area is taken up by the surface-mounted discrete passive components. Embedding these discrete components into the board structure has become the primary method to further miniaturize electronic systems. Besides the size reduction, embedded passives offer many other advantages. Reduced cost and improved electrical performance can be expected, and are actually another two major driving forces of embedded passive technology. To enable embedded passives, materials that satisfy the requirements of fabrication, electrical performance, and mechanical performance need to be developed. We report the innovative development of a low-cost high dielectric constant polymer-based composite that combines the advantages of polymer-ceramic and polymer-metal systems for embedded capacitor application. This novel material uses low cost self-passivated aluminum particles as the filler for the polymer composites. The thin self-passivated Al/sub 2/O/sub 3/ layer forms a nanoscale insulating boundary outside of the metallic spheres, which has dramatic influence on the electrical behavior of the resulting composites. The nanoscale insulating oxide layer allows the aluminum composites to have a high dielectric constant as a percolation system; on the other hand, the insulating oxide layer confines the electrons within an aluminum particle, thus keeping a very low loss of the composites.
Phosphorylation State-Dependent Interactions of Hepadnavirus Core Protein with Host Factors (2011)

Dynamic phosphorylation and dephosphorylation of the hepadnavirus core protein C-terminal domain (CTD) are required for multiple steps of the viral life cycle. It remains unknown how the CTD phosphorylation state may modulate core protein functions but phosphorylation state-dependent viral or host interactions may play a role. In an attempt to identify host factors that may interact differentially with the core protein depending on its CTD phosphorylation state, pulldown assays were performed using the CTD of the duck hepatitis B virus (DHBV) and human hepatitis B virus (HBV) core protein, either with wild type (WT) sequences or with alanine or aspartic acid substitutions at the phosphorylation sites. Two host proteins, B23 and I2PP2A, were found to interact preferentially with the alanine-substituted CTD. Furthermore, the WT CTD became competent to interact with the host proteins upon dephosphorylation. Intriguingly, the binding site on the DHBV CTD for both B23 and I2PP2A was mapped to a region upstream of the phosphorylation sites even though B23 or I2PP2A binding to this site was clearly modulated by the phosphorylation state of the downstream and non-overlapping sequences. Together, these results demonstrate a novel mode of phosphorylation-regulated protein-protein interaction and provide new insights into virus-host interactions.
一车激起千层浪——夏威夷不仅仅有阳光和海滩，还有香车：迷你Cooper。 (2008)

夏威夷的瓦胡岛虽小,但它拥有悠久而又多元的文化传统。Karl Kawachi的05年产迷你也同样如此,它并非无名小辈,而是响当当的大人物。由于其高品质的音响系统和卓越的改装工艺,Kawachi的迷你在瓦胡岛已是无人不知、无人不晓。
Salmonellosis in wild birds feeding at sewage treatment works (1978)

Between June 1976 and August 1977 faeces were collected from 599 wild British birds caught during ringing operations at two sewage treatment works in south-east England. Samples were incubated with selenite-F broth to detect the presence of Salmonella. Salm. anatum was isolated from one bird, a Dunnock Prunella modularis an incidence of 0.17% of the total birds examined and 3.23% of the Dunnocks. Comparisons are drawn with previously reported studies and it is suggested that sewage treatment works play little part in the transmission of Salmonella infections to wild birds feeding there.
Freeze-dried bone allografts in periodontal reconstructive surgery. (1991)

The objectives of a bone graft are reversal of the disease process, probing depth reduction, clinical attachment gain, clinical repair of lost bone, and histologic reconstruction of the attachment apparatus consisting of new bone, cementum, and periodontal ligament in an area previously exposed to bacterial plaque. The article discusses the current clinical and histologic state-of-the-art with regard to undermineralized freeze-dried bone allograft and demineralized freeze-dried bone allograft. Specific conclusions about the use of freeze-dried bone allograft are listed.
BRIDGING THE GAP BETWEEN BUSINESS STRATEGY AND SOFTWARE DEVELOPMENT Information Systems Strategy and Governance (2007)

In software-intensive organizations, an organizational management system will not guarantee organizational success unless the business strategy can be translated into a set of operational software goals. The Goal Question Metric (GQM) approach has proven itself useful in a variety of industrial settings to support quantitative software project management. However, it does not address linking software measurement goals to higher-level goals of the organization in which the software is being developed. This linkage is important, as it helps to justify software measurement efforts and allows measurement data to contribute to higher-level decisions. In this paper, we propose a GQM + Strategies measurement approach that builds on the GQM approach to plan and implement software measurement. GQM + Strategies ® provides mechanisms for explicitly linking software measurement goals to higher-level goals for the software organization, and further to goals and strategies at the level of the entire business. An example application of the proposed method is illustrated in the context of an example measurement initiative.
Telemedicine methods for low bit rate communication (2008)

Telemedicine using images usually requires high bit rate networks. In this work we investigated two scenarios for low bit rate communications: prepared teleconsultations (PT) and emergency teleconsultations (ET). In prepared teleconsultations multimedia objects can be earlier downloaded by each site and used in the synchronized event-driven architecture. We implemented a Java programming language Robot class which enables control of a remote graphical user interface. The local events are mapped to remote events. Their serialized versions are send to remote stations and executed. The required bandwidth is reduced to about kilobyte/second. In emergency teleconsultations the data object is encoded using JPEG 2000 and transmitted using scale and quality progression features. Using those features it is possible to control quality of the image in the region of interest. Concluding only required part of the image is send with the highest quality which leads to the reduction of the required bandwidth.
Effects of ginsenoside Rh2 on growth and migration of pancreatic cancer cells (2013)

Ginsenoside Rh2 inhibits proliferation, migration and invasion and induces apoptosis of the human pancreatic cancer cell line Bxpc-3.
Novel Mutations in ACVR1 Result in Atypical Features in Two Fibrodysplasia Ossificans Progressiva Patients (2009)

Fibrodysplasia Ossificans Progressiva (FOP) is a rare, heritable condition typified by progression of extensive ossification within skeletal muscle, ligament and tendon together with defects in skeletal development. The condition is easily diagnosed by the presence of shortened great toes and there is severe advancement of disability with age. FOP has been shown to result from a point mutation (c.617G>A) in the ACVR1 gene in almost all patients reported. Very recently two other mutations have been described in three FOP patients. We present here evidence for two further unique mutations (c.605G>T and c.983G>A) in this gene in two FOP patients with some atypical digit abnormalities and other clinical features. The observation of disparate missense mutations mapped to the GS and kinase domains of the protein supports the disease model of mild kinase activation and provides a potential rationale for phenotypic variation.
High-Tech High-Touch: Mission Possible? (2002)

As the result of assuming the role of a family member of a patient, the authors discovered that the stress made them really see how many nurses respond to patients' needs on a busy shift. They were dismayed at their reaction and immediately reverted to "Nursing 101." This article will describe the journey to establish the mission of restoring "Nursing 101" to the practice environment of an intensive care unit (ICU) and an intermediate care unit.
Search for Novel Aminoglycosides by Combining Fragment-Based Virtual Screening and 3D-QSAR Scoring (2009)

Aminoglycosides are antibiotics targeting the 16S RNA A site of the bacterial ribosome. There have been many efforts directed toward design of their synthetic derivatives, however with only few successes. As RNA binders, aminoglycosides are also a difficult target for computational drug design, since most of the existing methods were developed for protein ligands. Here, we present an approach that allows for evading the problems related to still poorly developed RNA docking and scoring algorithms. It is aimed at identification of new molecular scaffolds potentially binding to the A site. The considered molecules are based on the neamine core, which is common for all aminoglycosides and provides specificity toward the binding site, linked with diverse molecular fragments via its O5 or O6 oxygen atom. Suitable fragments are selected with the use of 3D searches of molecular fragments library against two distinct pharmacophores designed on the basis of available structural data for aminoglycoside-RNA complexes. The compounds resulting from fragments assembly with neamine are then scored with a 3D-QSAR model developed using the biological data for known aminoglycoside derivatives. Twenty-one new potential ligands are obtained, four of which have predicted activities comparable to less potent aminoglycoside antibiotics.
Editorial (2005)

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Analysis of the monocyte Fc receptors and antibody-mediated cellular interactions required for the induction of T cell proliferation by anti-T3 antibodies. (1985)

The induction of human T cell proliferation by antibodies that cross-link T3 antigens is dependent on functional interactions of anti-T3 antibodies with monocyte Fc receptors. In this report, we used a panel of anti-T3 antibodies of differing heavy chain isotype and a variety of other monoclonal antibodies to analyze several features of the antibody-mediated interactions between T cells and monocytes that are required for mitogenesis. Whereas three IgG2a anti-T3 antibodies were mitogenic for cells from all individuals, IgM and IgG2b anti-T3 antibodies did not induce T cell proliferation in any donor and could block the proliferative responses induced by other mitogenic anti-T3 antibodies. Dose-response analyses with four IgG1 anti-T3 antibodies demonstrated donor heterogeneity as reported by other investigators. However, in contrast to these previous reports, high concentrations of IgG1 anti-T3 antibodies were found to be mitogenic for all donors, indicating that this heterogeneity is based on relative rather than absolute defects in low responder monocytes. Cell mixing experiments in which monocytes from two different low responder donors were co-cultured with T cells and IgG1 anti-T3 antibodies did not identify any complementary defects, suggesting that the low responder phenotype results from a relatively restricted polymorphism. To assess the nature of the signals required for inducing T cell proliferation, nonmitogenic anti-T3 antibodies were co-cultured with other pan-T cell antibodies having the IgG2a isotype. The combination of signals from T3 antigen cross-linkage and those independently generated by other IgG2a antibodies bound to monocyte Fc receptors did not induce T cell proliferation. Hence, it appears that the T3 antigen or closely associated structures must be clustered at the monocyte membrane for mitogenesis. Finally, in competitive inhibition experiments, the isotype specificity of monocyte Fc receptors involved in the induction of T cell proliferation was examined. Two distinct Fc receptor sites, one that binds murine IgG2a and IgG3 antibodies and a second that binds murine IgG1 antibodies, were identified. Murine IgM or IgG2b did not appear to bind either of these receptor sites. Taken together, these data indicate that human monocytes have two distinct Fc receptor sites, which must specifically and directly interact with T cell-bound anti-T3 antibodies for mitogenesis.
Leakage Current Reduction Techniques in Poly-Si TFTs for Active Matrix Liquid Crystal Displays: A Comprehensive Study (2006)

This paper critically examines the leakage current reduction techniques for improving the performance of polycrystalline silicon (poly-Si) thin-film transistors (TFTs) used in active matrix liquid crystal displays. This is a first comprehensive study in literature on this topic. The review assesses important proposals to circumvent the leakage current problem in poly-Si TFTs and a short evaluation of strengths and weaknesses specific to each method is presented. Also, a new device structure called the triple-gate poly-Si TFT (TG-TFT) is discussed. The key idea in the operation of this device is to make the dominant conduction mechanism in the channel to be controlled by the accumulation charge density modulation by the gate and not by the gate-induced grain barrier lowering. Using two-dimensional and two-carrier device simulation, it is demonstrated that the TG-TFT exhibits a significantly diminished pseudosubthreshold conduction leading to several orders of magnitude reduction in the OFF-state leakage current when compared with a conventional poly-Si TFT. The reasons for the improved performance are explained
Prediction of passive intermodulation power level based on double exponential function model and genetic algorithm (2011)

The general idea and method of the predicting of passive intermodulation power level based on double exponential model is introduced in this paper. The general expression is deduced by using the measurement data of lower-level passive intermodulation power to predict higher-order passive intermodulation power level. The function's nonlinear coefficient is fitted by using genetic algorithm. Numerical calculation is realized on the basis of the measurement data of three-order passive intermodulation to predict fifth-order passive intermodulation power level. The calculated results are compared with the experimental data and the effectiveness and correctness of the algorithm is validated. The genetic algorithm's superiority is showed in passive intermodulation distortion power prediction.