gebhart/patrepeval huggingface dataset:
Characterization of a high-<i>M</i>r plasma-membrane-bound protein and assessment of its role as a constituent of hyaluronate synthase complex (1986)

A high-Mr phosphoprotein (Mr 442,000) was purified from Nonidet-P-40-solubilized plasma membranes of cultured human skin fibroblasts. The protein comprised one 200,000-Mr subunit consisting of 116,000- and 84,000-Mr polypeptides and two identical 121,000-Mr subunits each consisting of 66,000- and 55,000-Mr polypeptides. The 200,000-Mr subunit and its polypeptides contained phosphotyrosine residues and were also [32P]phosphorylated at these residues from [gamma-32P]ATP in vitro by an intrinsic tyrosine kinase activity of the protein molecule in response to the presence of hyaluronate precursors, UDP-glucuronic acid and UDP-N-acetylglucosamine. The 121,000-Mr subunits and their polypeptides contained phosphoserine residues that could not be [32P]phosphorylated during autophosphorylation of the protein in vitro. The protein molecules separated from exponential- and stationary-growth-phase cells were identical in their quaternary structure, but appeared to exist in different proportions with respect to the state of phosphorylation of their 121,000-Mr subunits during different growth phases of the cell. Phosphorylation of polypeptides appeared to predispose in favour of their UDP-glucuronic acid- and UDP-N-acetylglucosamine-binding activities. The phosphorylated 116,000- and 84,000-Mr polypeptides of 200,000-Mr subunits possessed a single binding site for UDP-glucuronic acid and UDP-N-acetylglucosamine respectively. The phosphorylated 200,000-Mr subunit could also cleave the UDP moiety from UDP-glucuronic acid and UDP-N-acetylglucosamine precursors. The phosphorylated 121,000-Mr subunit possessed two binding sites with equal affinity towards UDP-glucuronic acid and UDP-N-acetylglucosamine but did not possess UDP-moiety-cleavage activity. The phosphorylation of 200,000-Mr subunit by an intrinsic kinase activity of the protein molecule appeared to elicit its oligosaccharide-synthesizing activity, whereas phosphorylation of 121,000-Mr subunits, presumably carried out in vivo, abolished this activity of the protein molecule. The oligosaccharides synthesized by the protein were about Mr 5000 and about 12 disaccharide units in length. Neither nucleotide sugars nor glycosyl residues nor newly synthesized oligosaccharides were bound covalently to the protein molecule. The UDP moiety of nucleotide sugar precursors did not constitute a link between protein molecule and oligosaccharide during its synthesis. Although isolated 442,000-Mr protein did not synthesize high-Mr hyaluronate in vitro, this protein molecule can be considered as a constituent of membrane-bound hyaluronate synthase complex because of its observed properties.
Variations in Atmospheric CO2 Mixing Ratios across a Boston, MA Urban to Rural Gradient (2013)

Urban areas are directly or indirectly responsible for the majority of anthropogenic CO2 emissions. In this study, we characterize observed atmospheric CO2 mixing ratios and estimated CO2 fluxes at three sites across an urban-to-rural gradient in Boston, MA, USA. CO2 is a well-mixed greenhouse gas, but we found significant differences across this gradient in how, where, and when it was exchanged. Total anthropogenic emissions were estimated from an emissions inventory and ranged from 1.5 to 37.3 mg·C·ha−1·yr−1 between rural Harvard Forest and urban Boston. Despite this large increase in anthropogenic emissions, the mean annual difference in atmospheric CO2 between sites was approximately 5% (20.6 ± 0.4 ppm). The influence of vegetation was also visible across the gradient. Green-up occurred near day of year 126, 136, and 141 in Boston, Worcester and Harvard Forest, respectively, highlighting differences in growing season length. In Boston, gross primary production—estimated by scaling productivity by canopy cover—was ~75% lower than at Harvard Forest, yet still constituted a significant local flux of 3.8 mg·C·ha−1·yr−1. In order to reduce greenhouse gas emissions, we must improve our understanding of the space-time variations and underlying drivers of urban carbon fluxes.
Amenities, Natural Resources, Economic Restructuring, and Socioeconomic Outcomes in Nonmetropolitan America (2004)

This article explores the changing role of natural resources in community development in the United States. At one time, nonmetropolitan communities were dependent on traditional natural resources such as forests, minerals, and the soil, water, and climate necessary for agriculture. Where those resources were more abundant, populations were greater and life could be lived more abundantly. Amenity resources mattered little. It is apparent that circumstances have changed significantly. Data analyzed in this article explored the extent to which the presence or absence of amenity versus traditional natural resources influenced community development in recent years. A model was developed and tested to guide the analysis. It was found that from 1980 to 2000, communities with extensive amenity resources had a much greater increase in service employment. As a consequence of increased service sector employment, amenity rich counties had more extensive population growth. At the same time, high amenity communities also experienced a lower proportion of both adult males and females who are employed, an increased proportion of female-headed households, and higher poverty rates. These findings have significant implications for community leaders and community development specialists, which are discussed in this article.
Modulation of cell membrane area in renal collecting tubules by corticosteroid hormones. (1979)

Isolated renal cortical collecting tubules obtained from rabbits treated chronically with desoxycorticosterone acetate (DOCA) have been found to possess elevated transepithelial potential differences and a greatly increased capacity for ion transport. Structural exmination of tubules from rabbits exposed to either DOCA or dexamethasone for 11--18 d reveals a marked increase in basolateral cell membrane area in these tubules. Morphometric analysis shows that this effect is specifically on the basolateral membrane area of only one of the two cell types found in this nephron segment. Increases of greater than 140% and 90% are found for the basolateral membrane area of the principal cells for DOCA and dexamethasone, respectively, but no change could be detected in the basolateral membrane area of the intercalated cells found in this nephron segment. No siginificant changes were found in luminal membrane area, cell number, or cell volume for either cell type. These observations demonstrate that significant changes in membrane area can occur in differentiated epithelia and suggest that this may be an important mechanism for modulating epithelial transport capacity.
Severe Respiratory Dysrhythmia in Rett Syndrome Treated With Topiramate (2013)

Rett syndrome is a neurodevelopmental disorder that manifests itself early in childhood, progresses with the evolution of characteristic clinical signs and symptoms and is confirmed by mutation in the methyl-CpG-binding protein 2 gene. Seizures are present in a majority of Rett patients. Respiratory dysrhythmia in the awake state is present in two-thirds of patients, leading in some cases to severe nonepileptic paroxysmal events. There are no optimal treatment recommendations thus far. The aim of this case study is to present the electro-clinical correlation of severe respiratory dysrhythmia mimicking seizures in 2 Rett patients and effective treatment with topiramate.
Superconducting qubits coupled to nanoelectromechanical resonators: An architecture for solid-state quantum-information processing (2005)

We describe the design for a scalable, solid-state quantum-information-processing architecture based on the integration of GHz-frequency nanomechanical resonators with Josephson tunnel junctions, which has the potential for demonstrating a variety of single- and multiqubit operations critical to quantum computation. The computational qubits are eigenstates of large-area, current-biased Josephson junctions, manipulated and measured using strobed external circuitry. Two or more of these phase qubits are capacitively coupled to a high-quality-factor piezoelectric nanoelectromechanical disk resonator, which forms the backbone of our architecture, and which enables coherent coupling of the qubits. The integrated system is analogous to one or more few-level atoms (the Josephson junction qubits) in an electromagnetic cavity (the nanomechanical resonator). However, unlike existing approaches using atoms in electromagnetic cavities, here we can individually tune the level spacing of the ``atoms'' and control their ``electromagnetic'' interaction strength. We show theoretically that quantum states prepared in a Josephson junction can be passed to the nanomechanical resonator and stored there, and then can be passed back to the original junction or transferred to another with high fidelity. The resonator can also be used to produce maximally entangled Bell states between a pair of Josephson junctions. Many such junction-resonator complexes can be assembled in a hub-and-spoke layout, resulting in a large-scale quantum circuit. Our proposed architecture combines desirable features of both solid-state and cavity quantum electrodynamics approaches, and could make quantum-information processing possible in a scalable, solid-state environment.
OXIDATION PRODUCTS OF HUMULONE AND THEIR STEREOISOMERISM (1969)

Isomerization of tetrahydrohumulone can be accompanied by oxidation, since cis tetrahydrohumulinone is isolated from the reaction mixture. This compound can also be obtained by heat-induced isomerization of the known tetrahydrohumulinone, which is the trans form. By similar isomerization of the known humulinone, cis humulinone was prepared: this is probably an important intermediate produced from humulone during wort boiling. Trans and cis oxyhumulinic acids have been isolated for the first time. The conductivity of the boronate ester complexes of the humulinones and the oxyhumulinic acids confirms their trans or cis structures, as deduced from PMR characteristics.
[Coma due to an overdose of valnoctamide]. (1992)

We report a 27-year-old man, who became comatose after autopoisoning with a high dose of valnoctamide. He was mechanically ventilated for 12 hours and survived without serious side effects. Valnoctamide blood levels were monitored in order to study the pharmacokinetics of oral overdosing of this drug. Serum half-time levels appeared to be approximately 15 hours.
Direction-of-arrival and frequency estimations for narrowband sources using two single rotation invariance algorithms with the marked subspace (1992)

In array signal processing, one is frequently interested in simultaneously estimating the directions of arrival and the centre frequencies of the uncorrelated narrowband radiating sources having different centre frequencies. By using single spatial rotation invariance and temporal rotation invariance algorithms, e.g. the original ESPRIT, we can individually estimate the spatial frequencies αi and the temporal frequencies ωi of the sources. If detecting radiating sources only in azimuths is of interest, the spatial frequency αi is defined as αi= ωi sin (θi), where θi is the location of the ihe source relative to the broadside of the array, and we need decide which of the ωi and αi values belong to the same radiating source to obtain the pair {θi, ωi} for each source. In this paper, we propose a technique, the marked subspace technique, which is applied to the original ESPRIT to obtain the parameter pair {θi, ωi}. By using both single spatial invariance and single temporal invariance algorithms along with the marked subspace, the parameter pair {θi, ωi} of each radiating source can be more easily obtained than using the original ESPRIT without the marked subspace.
Isolation of West Nile virus from the brains of children who had died of encephalitis. (1984)

The isolation of West Nile virus from the brain tissue of three children who died of encephalitis in Mysore and Kolar districts of Karnataka State, India, is reported. This is the first such report from India. The significance of these isolations with reference to the role of West Nile virus in encephalitis in children in southern India is discussed.
Efficient Regular Expression Compression Algorithm for Deep Packet Inspection (2009)

A memory efficient regular expression compression algorithm is devised for deep packet inspection. First, a parameter DR (distending rate) is defined to quantify the explosive quality of regular expressions. Then based on DR, a regular expression cutting algorithm is proposed to downsize the storage needs of individual regular expression, by detecting and confining the parts which cause DFA (deterministic finite automaton) states’ exponential growth. Then according to the relation of different regular expressions, a selective grouping algorithm is introduced for regular expression sets, which could cut down the number of finite automata, and reduce the runtime memory consumption.
A Dispute Arbitration Protocol Based on a Peer-to-Peer Service Contract Management Scheme (2016)

Cloud computing has provided an attractive model for business service delivery. However, accountability aspects, mainly the monitoring of the execution of a service contract, liability assignment and dispute arbitration are still lacking. On the one hand, the traditional centralized monitoring and the trusted-third party (TTP) based arbitration solutions are not suitable for the distributed cloud environment. On the other hand, a decentralized solution also faces challenges in guaranteeing fairness, accuracy and sustainability. To address this issue, this paper firstly proposes an innovative service contract management scheme that facilitates the monitoring of the execution of a service contract in a peer-to-peer environment, inspired by the concept of blockchain in Bitcoin. Secondly, on top of the scheme it presents a novel dispute resolution protocol based on the Byzantine agreement and the commitment scheme. Thirdly, it identifies the optimal settings of the key parameters of the protocol through a set of experiments and scenario analysis, aiming to strike the balance of fairness, accuracy, incentive maximization for the honest arbiters and cost minimization for the overall arbitration process. With this approach, service participants can be held accountable in a truly distributed environment without the presence of a central authority, which increases businesses confidence on adopting cloud services.
GONAD DOSE IN THE PATIENT WITH X-RAY EXAMINATION OF THE INTESTINES (1973)

In our country, the X-ray examination of digestive organs contribute genetically significant dose. We tried to determine the gonad dose in the patient with X-ray examination of the intestines by the measurement of the phantom experiment. We infered positioning of patient from radiography of intestinal examination and measured the ovarian dose by the detector (TLD) in to the bladder of Machlett-Radiography phantom, and testis dose by attaching detector to the scrotum phantom of Mix-Dp. For intestinal examination, gonad of patient-usefull beam distance was an important factor of gonad dose in the patient with X-ray examination of the intestines.
The Influence of the Christiansen Effect on I.R. Spectra of Powders (1973)

Abstract The Christiansen effect appears in the i.r. spectrum of powders embedded in a solid, liquid or air matrix as an apparently anomalous transmittance (Christiansen peak) of the incident electromagnetic radiations. The peak appears at wavelengths for which the refractive index of the sample and the refractive index of the matrix are equal (Christiansen wavelength: λ Chr ). On account of the great variation of the sample refractive index in the immediate neighborhood of the absorption bands (anomalous dispersion curve), one often observes the occurrence of a transmittance peak or of a band deformation in this spectral range. A change in the position of this transmission peak with the value of the matrix refractive index is indicative of the Christiansen effect. The equality of the refractive indices of the sample and of the matrix for μ Chr has been used to determine some points of the anomalous dispersion curve in the neighborhood of the hydroxyl stretching band (3678 cm −1 ). Spectral distortions caused by the Christiansen effect can be reduced by preparing the sample in such a manner that the width at half-maximum (Δν 1/2 ) of the Christiansen peak is several times greater than this of the absorption band itself. Clarke’s theoretical formula, which gives an estimation of Δν 1/2 , has been qualitatively verified and thus gives an appropriate guide in the choice of the parameters which one can optimize during the sample preparation. One can reduce the Christiansen effect spectral modifications, without running the risk of modifying the sample itself, particularly by overly severe grinding.
Redox Environment, Free Radical, and Oxidative DNA Damage (2012)

In this review, we discuss the detrimental effects of ROS, oxidative DNA damage repair, and the redox systems that exist to control redox homeostasis. We also describe how DNA pathways can be modulated by the redox environment and how the redox environment and oxidative DNA damage plays a role in disease.
New canonic active RC realizations of grounded and floating inductors (1978)

Two new canonic active RC networks are proposed for the simulation of grounded and floating lossy inductors. A grounded inductor is simulated with one operational amplifier, four resistors and one grounded capacitor. The circuit for a floating inductor employs two amplifiers, six resistors, and only one capacitor.
Fundoplication for laryngopharyngeal reflux despite preoperative dysphagia (2017)

INTRODUCTION Fundoplication for laryngopharyngeal disease with oesophageal dysmotility has led to mixed outcomes. In the presence of preoperative dysphagia and oesophageal dysmotility, this procedure has engendered concern in certain regards. METHODS This paper describes a consecutive series of laryngopharyngeal reflux (LPR) patients with a high frequency of dysmotility. Patients were selected for surgery with 24-hour dual channel pH monitoring, oesophageal manometry and standardised reflux scintigraphy. RESULTS Following careful patient selection, 33 patients underwent fundoplication by laparoscopy. Surgery had high efficacy in symptom control and there was no adverse dysphagia. CONCLUSIONS Evidence of proximal reflux can select a group of patients for good results of fundoplication for atypical symptoms.
How can we improve the treatment of bone metastases further? (1998)

Bone is one of the most frequent organs to be affected by metastatic cancer and causes more morbidity than any other metastatic site. Bisphosphonate treatment provides an organ-specific treatment which is relevant to most if not all tumour types involving bone. Bisphosphonates, particularly the potent agent pamidronate (Aredia), will relieve metastatic bone pain with a consequent improvement in quality of life in approximately 50% of patients. Long-term bisphosphonate treatment clearly reduces skeletal morbidity rates in multiple myeloma and breast cancer.
Frequent False‐positive results of lupus anticoagulant tests in plasmas of patients receiving the new oral anticoagulants and enoxaparin (2013)

Dabigatran etexilate, RIV, and enoxaparin affect tests for LA not only in screening and mixing, but also in confirmatory studies. We considered that LA testing should not to be performed when patients are taken these drugs, particularly if blood is collected at peak, in order to avoid false-positive results.
Influence of Total Aggregate Gradation on Freeze-Thaw Durability and Other Performance Measures of Paving Concrete (1999)

Transportation-related agencies are experimenting with increased control of aggregate gradation in their concrete pavement specifications. There is anecdotal evidence that shows that total aggregate gradation can be optimized to yield improved concrete performance during construction and service life. Strong scientific data are less numerous in supporting this idea because of the variability in aggregates that can occur and practical considerations in avoiding waste particle sizes. The influence of total aggregate gradation on the freeze-thaw durability of concrete test specimens that employed a variety of sedimentary and igneous aggregates common in Wisconsin is examined. Optimized gradations consisted of increased amounts of aggregate particles in the No. 4 to No. 16 sieve size range and decreased amounts of fines in the No. 50 to No. 200 sieve size range. A near-gap gradation was fabricated by removing some particles in the No. 4 to No. 16 sieve size range and increasing the amount of fine material in the No. 30 to No. 100 sieve size range. Several methodologies and practical considerations were considered in establishing the aggregate gradations. A control gradation utilized a 60-40 blend of coarse/fine aggregate with gradations determined by the naturally occurring particle sizes. The concrete specimens prepared in this study were subject to strength, shrinkage, permeability, and accelerated freeze-thaw testing. All concretes had well-controlled water-cement ratios and showed excellent freeze-thaw durability. The optimized gradation mixes did not show consistently improved performance compared with the control mixes. The near-gap mixes showed reduced strength, reduced freeze-thaw durability, and increased shrinkage.
Charles W. Eliot and Education (1957)

“The worthy fruit of academic culture is an open mind, trained to careful thinking, instructed in the methods of philosophic investigation, acquainted in a general way with the accumulated thought of past generations, and penetrated with humility.”—Eliot at his inaugural as President of Harvard College, 1869
An Efficient Concurrent Auction Model For Firm Natural Gas Transportation Capacity (1992)

In accordance with the reform policy of the Federal Energy Regulatory Commission, open access to natural gas pipeline networks should allow large customers an opportunity to compete for cost-effective natural gas supplies. The competitive criterion is that all potential customers have equivalent access at the market clearing price to any building blocks in natural gas transportation service. Access to firm transportation capacity rights, defined as reliability priority blocks at critical bottlenecks, is a workable mechanism for planning and managing capacity allocations on the pipeline network. A concurrent auction optimization model provides an allocation of and prices for capacity rights for a given period, with allocations reflecting the willingness to pay.
THE NO-REFLOW PHENOMENON IN EXPERIMENTAL FREE FLAPS (1978)

The no-reflow phenomenon was studied following reconstitution of blood flow by microvascular anastomosis in an ischemic and denervated free epigastric flap in the rabbit. Microscopic, histological, angiographic, and hematological studies demonstrated the progressive nature of this obstruction to the peripheral blood flow after increasing periods of ischemia. This obstruction reached a point of irreversibility after 12 hours of ischemia, leading to ultimate death of these flaps. These results are consistent with the hypothesis that an ischemia-induced no-reflow phenomenon is caused by cellular swelling, intravascular aggregation, and the leakage of intravascular fluid into the interstitial space. Similarities between these experimental findings and human observations are made. The clinical importance of early diagnosis and treatment of ischemic tissues is emphasized.
A Simple Approach to Derive a Novel N-Soliton Solution for a （3＋1）-Dimensional Nonlinear Evolution Equation (2010)

基于 Hirota 双线性的形式，没有采用标准不安技术的一条简单途径，为构造一个新奇 N-soliton 答案为被介绍一(3+1 ) 维的非线性的进化方程。而且，新奇 N-soliton 答案被显示在 Mathematica 的帮助下有反响的行为。