gebhart/patrepeval huggingface dataset:
Hadronic charm production by gluon fusion (1978)

Rates for production of charmed particles in hadronic collisions are calculated in the gluon-fusion model. Aspects studied include the following: a comparison of the results obtained for different gluon distributions, angular and energy distributions expected for the produced charmed quarks, and dependence of the results on the mass of the "charmed" quark (this allows comparison of the rates for particles containing $s$, $c$, or $b$ quarks).
Amino terminal region of acute phase, but not constitutive, serum amyloid A (apoSAA) specifically binds and transports cholesterol into aortic smooth muscle and HepG2 cells (1996)

The human apoSAA proteins comprise both acute phase (apoSAA1, apoSAA2) and constitutive (apoSAA4) isoforms; all are expressed in human atherosclerotic lesions as well as in liver. Recombinant acute phase apoSAA binds cholesterol with an affinity of approximately 170 nM and enhances cholesterol uptake by HepG2 cells (J. Lipid Res. 1995. 36:37-46). In the present study, we sought to define the region of acute phase apoSAA involved in cholesterol binding and to investigate the ability of constitutive apoSAA4 to bind cholesterol. Binding of [3H]cholesterol to apoSAAp was inhibited by unlabeled cholesterol (1-100 nM), but not significantly by vitamin D and estradiol. Direct binding of acute phase, but not constitutive, apoSAA to the surfaces of polystyrene microtiter wells was strongly diminished in the presence of cholesterol. The ability of apoSAAp to bind cholesterol was inhibited by antibodies to human apoSAA1 and to peptide 1-18 of apoSAA1. There was only slight inhibition of cholesterol binding by antibodies to peptide 40-63, and no inhibition by antibodies to peptides spanning regions containing amino acid residues 14-44 and 59-104. [3H]cholesterol uptake by neonatal rabbit aortic smooth muscle and HepG2 cells was enhanced by a synthetic peptide corresponding to amino acids 1-18 of hSAA1, but not by peptides corresponding to amino acids 1-18 of hSAA4. [3H]cholesterol uptake by HepG2 cells was slightly increased by a peptide corresponding to amino acids 40-63 of hSAA1. These findings suggest that apoSAA modulates the local flux of cholesterol between cells and lipoproteins during inflammation and atherosclerosis.
The law of luminous intensity variation and technical vision (2013)

The success of majority of image processing solutions crucially depends from suitable lighting.In this paper, we study the problem of monitoring of passenger flows and consider an indirect method to take into account a luminous intensity variation.
Effect of Minor Elements on Grain Size of Mg-9%Al Alloy (2000)

The Influence of minor elements, such as Be. Zr, Fe and Mn. on grain size and grain-refining effect of Mg-9%Al alloy was investigated by use of high-purity Mg-9%Al alloy (high-purity alloy). This high-purity alloy was prepared from distilled pure magnesium and 99.99% commercial aluminum. Given amounts of Be. Zr, Fe and Mn were then added Microscopic examination clarified that these elements have grain coarsening action for natural fine-grained high-purity alloys, and the grain refinement by superheating was possible as long as the alloy grain was coarsened by Fe or Mn addition EPMA analysis revealed the existence of some species of aluminum carbide in high-purity alloy Fe-Al-C-O and Mn-Al-C-O compounds were also obscrved in allovs coarsc-grained by Fe or Mn addition Existence of aluminum carbide and its change were probably associated with the grain size of the Mg-9%Al alloy.
From international open government dataset search to discovery (2012)

In this poster, we will present the International Open Government Dataset Search (IOGDS). IOGDS is a faceted browsing interface for searching over more than one million open government datasets from around the world. We will present ongoing research and development towards the improved discovery and access to open government data. IOGDS has been designed around S2S, a framework for constructing user interfaces over Semantic Web services. We will discuss how the Web service abstraction layer in the S2S framework can be extended to support the use of external vocabularies to aid in the discovery of open government datasets. We will also discuss how the S2S framework can provide localization and context for non-expert users to improve the accessibility of open government data.
Hypertonic Saline as a Resuscitation Solution in Hemorrhagic Shock (1986)

A randomized double-blind study compared the dose-response relationship of epidural morphine for postoperative pain relief in two groups of patients whose surgical procedures would result in either moderate (femoral-popliteal bypass) or severe (total knee replacement) postoperative pain. Preservative- free morphine sulphate in doses of 0, 2, 5, or 10 mg in a volume of 10 ml saline were administered via lumbar epidural catheters. The epidural morphine was administered 1 hr after the last dose of intraoperative local epidural anesthetic in an effort to achieve a pain-free postoperative course. A significant relationship existed between the dose of epi- dural morphine and both time to first required pain medication and 24-hr weighted pain score. Five mg epidural morphine provided significant improvement in postoperative analgesia compared with the control in both groups. Further enhancement of analgesia occurred with 10 mg; however, late respiratory depression, demonstrated by an increased resting PaCO2 10 hr after administration, was seen only with the 10-mg dose in both surgical groups. Minor complications such as nausea, vomiting, pruritus, and urinary retention were uncommon and did not appear to be related to dose. We found that 5 mg epidural morphine provided long-lasting postoperative analgesia without serious adverse effects after peripheral vascular and orthopedic surgery.
Quantitative estimation of iron in Unani herbo-mineral products employing ion exchange chromatography (2005)

The ion exchange chromatography was conducted on Unani Syrup preparation of iron (Sharbat-e-faulad), manufactured by the three different pharmaceutical companies and compared with the standard Fesovit spansules. The ion exchanger was antimony (v) arsenosilicate, which is of crystalline nature and found to be highly selective for iron. The results indicate that the syrup manufactured by Hamdard (Wakf) Laboratories, Delhi (SFH) contains 96.11 + 3.5 mg/10 ml. The sample of Rex (U&A) Remedies Pvt. Ltd., Delhi (SFR) contains 78.4 + 1.5 mg/10 ml and Dwakhana Tibbia College, Aligarh (SFD) contains 30.37 + 1.8 mg/10 ml iron. The Fesovit spansules (FS) manufactured by Glaxo-Smith Kline Pharmaceuticals Ltd., Bangalore contains 47.7 + 0.9 mg per spansule. SFH comprises highest content of iron and most suitable for severe iron deficiency anaemia. SFR is the standard sample and negligible discrepancy noted in the content of iron claimed by manufacturer, whereas in SFD 25.308% less iron was determined in comparison to claimed amount of iron. Standard operational procedure (SOP) is required to be implemented for standard preparations of traditional medicines.
Presence of Bicarbonate Stimulated ATPase in the Brush Border Microvillus Membranes of the Proximal Tubule (1974)

SummaryA non-mitochondrial bicarbonate-stimulated adenosine triphosphatase has been localized in the brush border microvilli of rat proximal renal tubular cells. This finding is in accord with the putative role of this enzyme in the active transport of protons by the proximal tubule.
Sensor fault detection in etch based on broadband rf signal observation (2003)

To minimize machine downtime in semiconductor plasma etching processes, a sensor fault detection system was developed, employing a broadband rf sensor. The work presented here focuses on detecting errors in the transformer coupled power (TCP) measurement and pressure sensor, though the method has potential for several other sensors. To improve the detection sensitivity, we used real-time machine input estimation, and compared it against actual recipe settings instead of employing the raw rf signals directly. For a main etch process on a Lam TCP 9400SE, ±10% relative deviations in TCP measurement, or ±25% in pressure, can be detected with high accuracy: Detection probability PD≈1 and false alarm rate PF≈0 for both.
Interleukin‐10 modulates susceptibility in experimental cerebral malaria (1997)

In this study, we examined the effects of interleukin-10 (IL-10) on the outcome of experimental cerebral malaria (CM), a lethal neurological syndrome that occurs in susceptible strains of mice after infection with Plasmodium berghei ANKA (PbA). Constitutive IL-10 mRNA levels were significantly higher in the spleen and brain of resistant animals. In vivo neutralization of endogenous IL-10 in CM-resistant mice induced the neurological syndrome in 35.7% of these mice, as opposed to 7.7% in controls. IL-10 inhibited PbA antigen-specific interferon-gamma (IFN-gamma) production in vitro but not tumour necrosis factor (TNF) serum levels in vivo. Susceptible mice, on the other hand, were significantly protected against CM when injected with recombinant IL-10. Overall, our findings suggest that IL-10 plays a protective role against experimental cerebral malaria.
How Do People with Persecutory Delusions Evaluate Threat in a Controlled Social Environment? A Qualitative Study Using Virtual Reality (2013)

People with current persecutory delusions are able to use a range of similar strategies to healthy volunteers when making judgements about potential threat in a neutral environment that does not elicit anxiety, but they are less likely than controls to engage in active hypothesis-testing and instead favour experiencing "affect" as evidence of persecutory intention.
Alternative interpretation for data (1992)

Journal Article Alternative interpretation for data Get access Lawrence A. Trissel, FASHP Lawrence A. Trissel, FASHP Director Investigational Pharmaceutical Services, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 49, Issue 3, 1 March 1992, Page 570, https://doi.org/10.1093/ajhp/49.3.570a Published: 01 March 1992
Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design (2011)

Class D β-lactamases with carbapenemase activity are emerging as carbapenem-resistance determinants in gram-negative bacterial pathogens, mostly Acinetobacter baumannii and Klebsiella pneumoniae. Carbapenemase activity is an unusual feature among class D β-lactamases, and the structural elements responsible for this activity remain unclear. Based on structural and molecular dynamics data, we previously hypothesized a potential role of the residues located in the short-loop connecting strands β5 and β6 (the β5-β6 loop) in conferring the carbapenemase activity of the OXA-48 enzyme. In this work, the narrow-spectrum OXA-10 class D β-lactamase, which is unable to hydrolyze carbapenems, was used as a model to investigate the possibility of evolving carbapenemase activity by replacement of the β5-β6 loop with those present in three different lineages of class D carbapenemases (OXA-23, OXA-24, and OXA-48). Biological assays and kinetic measurements showed that all three OXA-10-derived hybrids acquired significant carbapenemase activity. Structural analysis of the OXA-10loop24 and OXA-10loop48 hybrids revealed no significant changes in the molecular fold of the enzyme, except for the orientation of the substituted β5-β6 loops, which was reminiscent of that found in their parental enzymes. These results demonstrate the crucial role of the β5-β6 loop in the carbapenemase activity of class D β-lactamases, and provide previously unexplored insights into the mechanism by which these enzymes can evolve carbapenemase activity.
Naltrexone long-acting formulation in the treatment of alcohol dependence. (2007)

While oral naltrexone has a demonstrated ability to decrease alcohol reinforcement, it also has pharmacotherapeutic limitations, such as a small treatment effect size, adverse events, and plasma level fluctuations. The pharmacokinetic profile of naltrexone could be enhanced by intramuscular administration, which would sustain its release over several weeks and keep plasma levels relatively constant, ie, low enough to minimize side effects but high enough to reduce drinking. Vivitrex((R))/Vivitrol((R)) and Naltrel((R)) are injectable naltrexone depot formulations that have been tested as possible medications for treating alcohol dependence. Their adverse-event profiles appear to be less severe than that of oral naltrexone. Vivitrex((R))/Vivitrol((R)) has demonstrated efficacy at decreasing heavy drinking among alcohol-dependent males. Naltrel((R)) helped to promote abstinence and decrease the incidence of relapse in two samples of alcohol-dependent subjects. The data on a third formulation, Depotrex((R)), are still limited. All three formulations require further study of their efficacy.
AGING AND RUNNING RELATED TO PERIPHERAL BLOOD FLOW (1982)

Cunningham, L. N.; Labrle, C.; Soeldner, J. S.; Gleason, R. E.; Anderson, N.; Joslin, E. P. Author Information
Human Thyroglobulin and Thyroid Extract as Specific Stimulators of Sensitized Lymphocytes (1971)

Lymphocytes from peripheral blood of patients with various thyroid diseases and of healthy volunteers were tested for blast transformation reaction by human thyroglobulin, thyroid extract, adrenal extract, phytohemagglutinin (PHA) and staphylococcal nitrate (SF). The subjects comprised 9 patients with Hashimoto's disease, 12 hypothyroids, 8 with nontoxic goiter, 10 thyrotoxics, and 15 healthy controls. Lymphocytes from 6 of the patients with Hashimoto's disease were specifically stimulated to transform by human thyroglobulin or thyroid extract, while, among the other groups tested, only one patient with nontoxic goiter demonstrated a significant specific stimulation. It is suggested that the specific blast transformation may be caused by auto-immunization to thyroid antigens.
Fire test method for graphite fiber reinforced plastics (1980)

A potential problem in the use of graphite fiber reinforced resin matrix composites is the dispersal of graphite fibers during accidential fires. Airborne, electrically conductive fibers originating from the burning composites could enter and cause shorting in electrical equipment located in surrounding areas. A test method for assessing the burning characteristics of graphite fiber reinforced composites and the effectiveness of the composites in retaining the graphite fibers has been developed. The method utilizes a modified rate of heat release apparatus. The equipment and the testing procedure are described. The application of the test method to the assessment of composite materials is illustrated for two resin matrix/graphite composite systems.
Fertility preservation in breast cancer patients: A prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservation (2005)

ObjectiveTo develop safe ovarian stimulation methods to perform in vitro fertilization (IVF) in breast cancer patients who wish to preserve their fertility via embryo cryopreservation before chemotherapy.
Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix (2014)

This review discusses our current understanding of how the expression and turnover of components of the cartilage extracellular matrix (ECM) have been investigated, both as molecular markers of arthritis and as indicators of disease progression. The cartilage ECM proteome is well studied; it contains proteoglycans (aggrecan, perlecan and inter-α-trypsin inhibitor), collagens and glycoproteins (cartilage oligomeric matrix protein, fibronectin and lubricin) that provide the structural and functional changes in arthritis. However, the changes that occur in the carbohydrate structures, including glycosaminoglycans, with disease are less well studied. Investigations of the cartilage ECM proteome have revealed many potential biomarkers of arthritis. However, a clinical diagnostic or multiplex assay is yet to be realized due to issues with specificity to the pathology of arthritis. The future search for clinical biomarkers of arthritis is likely to involve both protein and carbohydrate markers of the ECM through the application of glycoproteomics.
On Scenario-based Model-driven Configuration Management for Flexible Networking Experimentation Infrastructures (2010)

The goal of the present dissertation is to improve the current state of the art in configuration management in networking experimentation infrastructures (testbeds). In particular, our goal is to solve the scenario technology-dependency problem, so the same scenarios can be reused in different testbeds. In order to achieve this goal, three objectives have to be addressed. First, to develop a model-driven configuration management architecture that decouples scenario specifications from the testbeds in which they will be finally deployed. This has to be done without modifying existing testbeds or their management tools. Secondly, a Testbed Independent Model (TIM), based on DMTF's CIM, used as main architectural component in order to provide scenario technology-independency. Finally, a generic and systematic methodology to transform TIM scenarios to the specification formats used in the different current or future testbeds. In order to achieve these objectives, our work includes an extensive analysis of the most salient experimentation infrastructures existing today, paying special attention to their configuration management systems. In addition, different technologies to model and transform management information are analyzed, in order to find the best one to base our architecture on. This dissertation also includes an experimental validation to assess the feasibility of our architecture, which is applied to two different testbeds used for real world experimentation. Additionally, several application cases are described, both for novel testbed architectures (such as the ones defined in Future Internet initiatives) and production environments.
$p$-Capacity and $p$-Hyperbolicity of Submanifolds (2009)

We use explicit solutions to a drifted Laplace equation in warped product model spaces as comparison constructions to show $p$-hyperbolicity of a large class of submanifolds for $p\ge 2$. The condition for $p$-hyperbolicity is expressed in terms of upper support functions for the radial sectional curvatures of the ambient space and for the radial convexity of the submanifold. In the process of showing $p$-hyperbolicity we also obtain explicit lower bounds on the $p$-capacity of finite annular domains of the submanifolds in terms of the drifted $2$-capacity of the corresponding annuli in the respective comparison spaces.
Induction of interleukin‐1β production in human dermal fibroblasts by interleukin‐1α and tumor necrosis factor‐α. Involvement of protein kinase‐dependent and adenylate cyclase‐dependent regulatory pathways (1991)

It has previously been demonstrated that interleukin-1 (IL-1) is expressed in a variety of fibroblast cell lines. In this study, we investigated the mechanisms involved in the regulation of IL-1 beta production by cultured human dermal fibroblasts. We have shown that IL-1 beta is constitutively expressed as a cell-associated form, with no soluble form detectable in control cell or in stimulated cell supernatants. IL-1 alpha and tumor necrosis factor-alpha (TNF-alpha) exerted a dose-dependent stimulation on the production of the cell-associated IL-1 beta, as estimated using a specific enzyme linked immunosorbent assay (ELISA). As expected, this effect was accompanied by a huge release of prostaglandin E2 (PGE2) and a transient rise in intracellular cyclic AMP. Furthermore, IL-1 beta production was elevated to a lesser extent by the addition of increasing concentrations of the protein kinase C activator phorbol myristate acetate or by low concentration (0.001 microgram/ml) of PGE2. In contrast, higher concentrations (0.1 and 1 micrograms/ml) of PGE2, as well as exogenous dibutyryl-cyclic AMP, were clearly inhibitory. H7, an inhibitor of protein kinases also reduced the stimulatory effect of IL-1 alpha and TNF-alpha. Together with the results obtained with phorbol myristate acetate, these data suggest that protein kinase C may play a role in the upregulation of IL-1 beta expression in normal skin fibroblasts. The addition of indomethacin not only suppressed prostaglandin synthesis, but also dramatically reduced cyclic AMP formation, probably because the PGE2-induced stimulation of adenylate cyclase was abolished. This resulted in a strong potentiation of the stimulatory effect of IL-1 alpha and TNF-alpha, supporting the role of both the cyclooxygenase and adenylate cyclase pathways in the endogenous downregulation of IL-1 beta induction by the two cytokines studied.
Field Experiences with a Combined Acid Stimulation and Scale Inhibition Treatment (2001)

Abstract Calcium carbonate scale impacts oil production in a large number of fields worldwide. This scale is generally managed by acid washing to remove the scale and/or by performing scale inhibition treatments. The methodology adopted is usually cost driven with high cost operations generally selecting scale prevention rather than removal. Recently reported work 1 showed the potential to integrate scale removal and scale inhibition treatments into a single package, offering clear economic and technical advantages. The combined treatment inherently reduces well intervention costs and well downtime, and protects the value added by the scale removal treatment - by assuring that all of the zones that are stimulated are also inhibited. Combining acid stimulation chemicals and scale inhibitors is by no means a simple process. Compatibility between the acid, the acid additives and the scale inhibitor presents a significant issue in both live and spent acids. This paper will examine these technical challenges and describes the desired properties of such combined systems. Case histories of recent field trials of combined scale removal and inhibition treatments will be presented, including details of job design, job execution and post-job evaluation. Data demonstrating the scale inhibitor return profile in these treatments will be shown, and lessons learnt from the initial trials will be discussed. Comparative performance data for previous acid treatments will also be presented.
A comparison between cardiac output determined by impedance cardiography and the rebreathing method during exercise in man. (1989)

Cardiac output was determined by impedance cardiography (Q(imp)) and a rebreathing method (Q(reb)) during exercise of loads up to 90W. The correlation between Q(imp) and Q(reb) was generally good, but it was found in two of four subjects that Q(imp) was slightly lower than Q(reb) at the higher exercise levels. The regression equation for both Q values was: Q(imp)=0.91Q(reb)+0.25 (l/min, r=0.87, p<0.001).