gebhart/patrepeval huggingface dataset:
Studies on antibiotics from the genus Bacillus. IV. Isolation of a new peptide antibiotic TL-119. (1975)

A new antibiotic TL-119 active against gram-positive bacteria was isolated from a strain resembling Bacillus subtilis. The antibiotic is a neutral substance, soluble in a mixture of chloroform and methanol, and is a peptide with an empirical formula of C42H57N7O9, containing threonine (1), alanine (1), valine (1), leucine (1) and phenylalanine (2).
ChemInform Abstract: SYNTH. MIT ALPHA‐METALLIERTEN ISOCYANIDEN 18. MITT. 1‐AMINO‐CYCLOPROPANCARBONSAEUREN UEBER 1‐ISOCYAN‐CYCLOPROPANCARBONSAEURE‐AETHYLESTER (1973)

Abstract Die nach Literatur dargestellten Aminoacrylsäureester (I) lassen sich mit Phosgen in Gegenwart von Triäthylamin zu den Derivaten (II) dehydratisieren, deren Umsetzung mit dem Sulfoxoniummethylid (III) die Cyclopropancarbonsäureester (IV) liefert.
A Convenient Regioselective Synthesis of Mannich Bases (1986)

A new, convenient regioselective process for aminomethylation of ketones is reported, involving the in situ formation of silyl enol ethers and iminium salts.
BASIC AMIDES AS ANTISPASMODIC AGENTS. I (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBASIC AMIDES AS ANTISPASMODIC AGENTS. IL. C. CHENEY, W. B. WHEATLEY, M. E. SPEETER, W. M. BYRD, W. E. FITZGIBBON, W. F. MINOR, and S. B. BINKLEYCite this: J. Org. Chem. 1952, 17, 5, 770–777Publication Date (Print):May 1, 1952Publication History Published online1 May 2002Published inissue 1 May 1952https://pubs.acs.org/doi/10.1021/jo01139a017https://doi.org/10.1021/jo01139a017research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bioinformatics Analysis and Validation of the Expressed Sequences Tag in Human Colorectal Adenocarcinoma (2009)

The ES274070, ES274071, ES274076 and ES274081 are related to the onset of human colorectal adenocarcinoma.
<title>N-i-p-i-based high-speed detectors and bistable switches with gain</title> (1992)

We report on recent theoretical and experimental results on reverse biased photoconductive detectors and bistable optical switches. Using a special design and taking advantage of the 'giant ambipolar diffusion constant' of n-i-p-i structures, the photogenerated carriers are transferred from the 'absorption area' into a small detection area within very short times. The combination of small contact separations and small RC- and diffusion time constants results in very high gain-bandwidth values with adjustable 3-dB frequencies.
Generation of [.beta.-(phenylsulfonyl)alkylidene]carbenes from hypervalent alkenyl- and alkynyliodonium tetrafluoroborates and synthesis of 1-(phenylsulfonyl)cyclopentenes (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneration of [.beta.-(phenylsulfonyl)alkylidene]carbenes from hypervalent alkenyl- and alkynyliodonium tetrafluoroborates and synthesis of 1-(phenylsulfonyl)cyclopentenesMasahito Ochiai, Munetaka Kunishima, Shohei Tani, and Yoshimitsu NagaoCite this: J. Am. Chem. Soc. 1991, 113, 8, 3135–3142Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ja00008a049https://doi.org/10.1021/ja00008a049research-articleACS PublicationsRequest reuse permissionsArticle Views678Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biochemical engineering : renewable sources of energy and chemical feedstocks (1978)

This book explores in detail the concept of biologically processing crop, forestry, and animal wastes into various forms of energy. It is based on papers presented at two symposia: Biochemical Sources of Energy held at the Second Pacific Chemical Engineering Congress in Denver in 1977, and Biological Sources of Energy and Chemical Feedstocks which was presented at the AIChE 84th National Meeting in Atlanta in 1978. Four areas are covered: sources and availability of substrates, lignin utilization, overview of process technologies, and fuels and feedstock production. The collection of papers focus on the major issues of raw materials supply, conversion to various fuel and feedstock components, and scale-up to practical processes.
Atypical Atrial Flutter Originating in the Right Atrial Free Wall (2000)

Atrial flutter can arise in the right atrial free wall. This form of atypical atrial flutter could account for spontaneous or inducible atrial flutter observed in patients referred for ablation and is eliminated with linear ablation directed at the inferolateral right atrium.
Experimental Testing and Numerical Simulations of Shrouded Plug-Nozzle Flowfields (2012)

The static tests of Purdue experimental shrouded plug nozzle which is a sub-scale model of the Gulfstream concept without the bypass exhaust stream is the focus of current computational and experimental effort. The static tests brought to light unsteady characteristics related shock/shock and shock/boundary layer interactions. Through a series of steady and unsteady axisymmetric computations the flow structure and physics were studied and the computational results were found to be in good agreement with experimental observations. Primarily flow structures, flow regimes and static pressure distributions were computationally studied and analyzed in conjunction with the experiments.
The Role of Anti-Cyclic Citrullinated Peptide Antibody in Periodontal Disease (2010)

The anti-Cyclic Citrullinated Peptide Antibodies (anti-CCP) are produced locally in the inflamed synovium of Rheumatoid arthritis (RA) patients, suggesting that citrullinated proteins are located in the inflamed synovium. In scientific literature were find periodontal bacterial DNA in serum and synovial fluid of RA with PD patients. RA and adult periodontitis share common pathogenetic mechanisms and immunologic and pathological findings RA. One oral pathogen strongly implicated in the pathogenesis of periodontal disease (PD), Porphyromonas. gingivalis, possesses a unique microbial enzyme, peptidylarginine deiminase (PAD), the human equivalent of which has been identified as a susceptibility factor for RA. Under this point of view, we speculate about the presence of anti-CCP antibodies in sera of PD with RA patients. We conducted this study to evaluate and compare the diagnostic and predictive utility of anti-CCP antibodies in patients with PD and patients with PD and RA. Anti-CCP antibody was not found in 21 sera (U/ml<10), included RA controls, while only 1 patient with chronic PD and probing depth of 7,1 mm was identified positive for anti-CCP (22.2 U/ml). Our data do not support a role for anti-CCP in diagnoses of periodontal disease.
Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms (2002)

Members of the postsynaptic density-95 (PSD95)/synapse-associated protein-90 (SAP90) family of scaffolding proteins contain a common set of modular protein interaction motifs including PDZ (postsynaptic density-95/Discs large/zona occludens-1), Src homology 3, and guanylate kinase domains, which regulate signaling and plasticity at excitatory synapses. We report that N-terminal alternative splicing of PSD95 generates an isoform, PSD95beta that contains an additional "L27" motif, which is also present in SAP97. Using yeast two hybrid and coimmunoprecipitation assays, we demonstrate that this N-terminal L27 domain of PSD-95beta, binds to an L27 domain in the membrane-associated guanylate kinase calcium/calmodulin-dependent serine kinase, and to Hrs, an endosomal ATPase that regulates vesicular trafficking. By transfecting heterologous cells and hippocampal neurons, we find that interactions with the L27 domain regulate synaptic clustering of PSD95beta. Disrupting Hrs-regulated early endosomal sorting in hippocampal neurons selectively blocks synaptic clustering of PSD95beta but does not interfere with trafficking of the palmitoylated isoform, PSD95alpha. These studies identify molecular and functional heterogeneity in synaptic PSD95 complexes and reveal critical roles for L27 domain interactions and Hrs regulated vesicular trafficking in postsynaptic protein clustering.
ChemInform Abstract: Zirconacyclopentadienes: Preparation and Applications in Organic Syntheses (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Demonstration of Her-2 Protein in Cervical Carcinomas (2003)

OBJECTIVE.: Recently, an immunohistochemical test for her-2-neu has been approved by the Food and Drug Administration for evaluation of breast cancer patients who might benefit from treatment with Herceptin (HercepTest). This study was undertaken to evaluate the immunohistochemical staining patterns in cervical cancer and correlate with clinical parameters. MATERIALS AND METHODS.: A total of 24 cases of invasive squamous cell carcinoma of the cervix were evaluated. Cases were stained using the HercepTest kit according to protocol. Results were graded from 0 to 3+, using the standards set for breast lesions. RESULTS.: A total of 17 cases (70.8%) were negative, 3 cases (12.5%) showed 1+ staining, and 4 cases (16.7%) showed 2+ staining. No cases showed 3+ staining. Higher her-2 staining grade correlated strongly with vaginal margin status. A weak positive correlation was seen between her-2 staining and tumor stage. There was no correlation with tumor grade or histological lymph node status. CONCLUSIONS.: A subset of invasive squamous cell carcinomas of the cervix overexpress her-2 protein. Further studies are needed to correlate with clinical outcome and determine if overexpression of her-2 protein is a marker of cervical carcinoma aggressiveness.
Effects of pre-annealing on the uni- and bi-axial stretching behavior of poly(ethylene naphthalate) films (2014)

Effect of pre-annealing on stress and birefringence behavior of poly(ethylene naphthalate) (PEN) films during stretching and relaxation processes was investigated. Amorphous and non-oriented PEN films were pre-annealed under the conditions of different temperatures and periods. The pre-annealed films were stretched uniaxially or equi-biaxially and then relaxed at fixed length. It was found that pre-annealing did not cause any notable change for the initial behavior of refractive indices variation, whereas the behaviors after necking were significantly affected. Through the comparison between in-plane and out-of-plane birefringence and the analysis of wide-angle x-ray diffraction patterns of drawn films of both stretching modes, it was confirmed that the orientation of naphthalene ring in the film plane was enhanced by pre-annealing.
MicroRNA Expression Patterns and Function in Endodermal Differentiation of Human Embryonic Stem Cells (2008)

Our results demonstrate that expression of specific miRNAs correlates with that of specific genes upon differentiation, and highlight the potential role of miRNAs in endodermal differentiation of hESC.
Supercritical Fluid Extraction of Plutonium and Americium from Soil Using β-Diketone and Tributyl Phosphate Completants (2003)

Supercritical fluid extraction (SFE) of plutonium and americium from soil was demonstrated using supercritical fluid carbon dioxide solvent augmented with organophosphorus and beta-diketone complexants. Soil from a radioactive waste management site in Idaho was spiked with plutonium and americium, chemically and radiologically characterized, then extracted with supercritical fluid carbon dioxide at 2,900 psi and 65 °C. The organophosphorus reagent tributyl phosphate (TBP) and the beta-diketone thenoyltrifluoroacetone (TTA) were added to the supercritical fluid as complexing agents. A single 45 minute SFE with 2.7 mol% TBP and 3.2 mol% TTA provided as much as 88% ± 6 extraction of americium and 69% ± 5 extraction of plutonium. Use of 5.3 mol% TBP with 6.8 mol% of the more acidic betadiketone hexafluoroacetylacetone (HFA) provided 95% ± 3 extraction of americium and 83% ± 5 extraction of plutonium in a single 45 minute SFE at 3,750 psi and 95 °C. Sequential chemical extraction techniques were used to chemically characterize soil partitioning of plutonium and americium in pre-SFE soil samples. Sequential chemical extraction techniques demonstrated that spiked plutonium resides primarily (69% ± 2) in the sesquioxide fraction with minor amounts being absorbed by the oxidizable fraction (18% ± 1) and residual fractions (8% ± 1). Post-SFE soils subjected to sequential chemical extraction characterization demonstrated that 97% ± 3 of the oxidizable, 79% ± 2 of the sesquioxide and 80% ± 2 of the residual plutonium could be removed using SFE. These preliminary results show that SFE may be an effective solvent extraction technique for removal of actinide contaminants from soil.
Conformational dependence of the Raman scattering intensities from polynucleotides (1971)

Abstract The intensity of Raman scattering from the various Raman active vibrations of poly‐(riboadenylic acid), poly(ribocytidylic acid), poly(ribouridylic acid), and poly(riboinosinic acid) in moderately dilute solutions were examined as the temperature was changed to alter their conformation. It was found that certain highly intense, highly polarized Raman bands from the totally symmetric, i.e., in‐plane, ring vibrations of the nucleic acid bases become less intense as the chains become more ordered in solution. Since these vibrations occur at frequencies which are markedly different for each type of base, Raman spectroscopy appears to provide a new method for the characterizing of the average conformation of each of the bases in solution. A theory for the resonant Raman effect is given in which it is shown that, a decrease in resonant Raman intensity is to be expected if one obtains a decrease in the intensity of the corresponding ultraviolet absorption band with which the incident light is resonant. If it is assumed that certain Raman bands derive their intensity predominantly from the first few ultraviolet absorption intensities, then a qualitative explanation of our observed conformational dependence of the ordinary Raman intensities can be obtained.
Label-Free Dopamine Imaging in Live Rat Brain Slices (2014)

Dopaminergic neurotransmission has been investigated extensively, yet direct optical probing of dopamine has not been possible in live cells. Here we image intracellular dopamine with sub-micrometer three-dimensional resolution by harnessing its intrinsic mid-ultraviolet (UV) autofluorescence. Two-photon excitation with visible light (540 nm) in conjunction with a non-epifluorescent detection scheme is used to circumvent the UV toxicity and the UV transmission problems. The method is established by imaging dopamine in a dopaminergic cell line and in control cells (glia), and is validated by mass spectrometry. We further show that individual dopamine vesicles/vesicular clusters can be imaged in cultured rat brain slices, thereby providing a direct visualization of the intracellular events preceding dopamine release induced by depolarization or amphetamine exposure. Our technique opens up a previously inaccessible mid-ultraviolet spectral regime (excitation ~270 nm, emission < 320 nm) for label-free imaging of native molecules in live tissue.
ELLIS‐<scp>van</scp> CREVELD SYNDROME (1967)

An autopsy case of chondroectodermal dysplasia (Ellis‐van Creveld syndrome) was reported, in which the four major features (chondrodysplasia, ectodermal dysplasia, polydaktylia and heart anomaly) were all present. Cause of death was attributed to the congenital cardiac anomaly (cor triloculare biventriculare). No consanguity between parents was proved. Roentgenologic and histopathologic findings of the bone were described.
<title>Fluorescence scanning near-field optical microscopy (FSNOM) by measuring the decay time of a fluorescent particle</title> (1995)

We propose a Fluorescent Scanning Near-Field Optical Microscope (FSNOM) based upon the measurement of the decay time of a fluorescent particle adsorbed on a SNOM tip. The purpose of the experiment is to measure the decay time variations of the fluorescent particle when the tip is scanned at a few nanometers from the surface of a sample. We describe the experimental set-up and present a theoretical model: it calculates, by a perturbation method, the variations of the life-time on a rough surface. The formalism is rapidly described and first theoretical life- time signals are presented.
Recent developments in the laser spallation technique to measure the interface strength and its relationship to interface toughness with applications to metal/ceramic, ceramic/ceramic and ceramic/polymer interfaces (1995)

Recent developments in the laser spallation technique to measure the interface strength and its relationship to interface toughness with applications to metal/ceramic, ceramic/ceramic and ceramic/polymer interfaces was published in Adhesion Measurement of Films and Coatings on page 367.
Stress-Corrosion Cracking of Stainless Steel Superheater Tubing (1993)

Abstract Several 304H stainless steel superheater tubes fractured in stressed areas within hours of a severe caustic upset in the boiler feedwater system. Tests performed on a longitudinal weld joint, which connected two adjacent tubes in the tertiary superheater bank, confirmed caustic-induced stress-corrosion cracking, promoted by the presence of residual welding stresses. Improved maintenance of check valves and routine inspection of critical monitoring systems (conductivity alarms, sodium analyzers, etc.) were recommended to help avoid future occurrences of severe boiler feedwater contamination. Additional recommendations were to eliminate these short longitudinal weld joints by using a bracket assembly joint between the tubes, use a post-weld heat treatment to relieve residual welding stress or select a more stress-corrosion cracking resistant alloy for this particular application.
Don't forget Langmuir–Blodgett films (2004)

Langmuir-Blodgett (LB) films have been investigated, extensively, over the past 70 years. Despite considerable efforts aimed at exploiting their nonlinear optical, piezoelectric, pyroelectric, semiconducting, sensing and barrier properties, problems associated with film quality and stability have hampered their practical development. This feature article highlights one recent advance in the LB area (i.e., the ionic cross-linking of LB films or "gluing"), which has resulted in single bilayer membranes possessing extraordinary quality and stability. The gluing of LB films provides new opportunities for an old technology that has been waning in recent years.
Algorithmes statistiques pour le traitement des images polarimétriques en lumière cohérente (2001)

L'imagerie polarimetrique consiste a former une image de l'etat de polarisation de la lumiere reflechie par une scene. En particulier, l'image du degre de polarisation constitue une methode puissante pour detecter des objets qui n'apparaissent pas sur les images d'intensite classiques. Cependant, dans les imageurs actifs illuminant la scene avec une lumiere coherente (laser), les images de degre de polarisation sont fortement perturbees a cause du phenomene de speckle. Il est donc necessaire d'utiliser des algorithmes de traitement adaptes a leurs proprietes statistiques. Nous proposons tout d'abord d'etudier le modele de densite de probabilite des images de degre de polarisation, puis nous analysons les proprietes des differents estimateurs du degre de polarisation a partir de ces images. Nous caracterisons ensuite les performances d'algorithmes statistiques de detection de cibles et de bords, ainsi que des methode de segmentation d'objets par contour actif statistique. L'une des principales conclusions est que pour ces operations de traitement, il est preferable de travailler non pas avec l'image de degre de polarisation classique, mais avec une transformation non-lineaire de celle-ci, que nous appelons « representation naturelle » des images de degre de polarisation.
Formation and disappearance of pores in aluminum alloy molten pool under microgravity (2004)

With the start of construction of the international space station, a welding technique in space is becoming essential for the construction and repair of space structures. We now describe the results obtained under microgravity by electron beam welding, which is thought to be the most probable candidate for space welding. The microgravity environments were achieved using the drop-shaft system at the Japan Microgravity Center. The system can produce a microgravity of 10–25 G and a duration of 10 s. The sample was an aluminum–copper alloy, 2219, which is commonly used in the aerospace industry. The effective diameter of the electron beam was set at approximately 3 mm in order to prevent the keyhole formation. A significant decrease in the number of the pores in the Al alloys was observed under microgravity. All of the pores smaller than 100 μm disappeared for both microgravity and terrestrial environments. These results indicate that there exists a new bubble formation mechanism, consisting of a reaction between the molten Al and Al2O3 forming Al2O gas, and that the convection due to the Marangoni flow is negligible in an Al molten pool.