gebhart/patrepeval huggingface dataset:
Catabolite Repression of the Xylanase Gene (<i>xynA</i>) Expression in<i>Bacillus stearothermophilus</i>No. 236 and<i>B. subtilis</i> (1999)

Catabolite repression of the Bacillus stearothermophilus No. 236 xynA gene, encoding an extracellular xylanase, was investigated in this work. Expression of the xynA gene in the B. stearothermophilus strain was found to be subject to glucose catabolite repression, and the level of repression was about 50-fold when the relative amounts of xynA transcript synthesized on different carbon sources were analyzed. The experiments with the B. subtilis MW15 strains carrying plasmids containing the xynA::aprA fusion gene showed that the cloned xynA gene did not require any specific carbon source for its induction. Nevertheless, the expression of the cloned gene was repressed by the presence of glucose. From the nucleotide sequence of the cloned xynA gene, we found two potential catabolite responsive elements (cre) within its reading frame region (cre-1: nucleotides +160 to +173 and cre-2: +173 to +186). Furthermore, by using various deletion derivatives of the xynA::aprA fusion plasmid (pMGW23), we suggested that only the cre-2 element might play a role in the glucose catabolite repression. Repression level of the xynA gene expression in the recombinant B. subtilis strain was estimated to be about 3-fold by analysis of the amounts of xynA transcript.
The Definitive ANTLR Reference: Building Domain-Specific Languages (2007)

ANTLR v3 is the most powerful, easy-to-use parser generator built to date, and represents the culmination of more than 15 years of research by Terence Parr. This book is the essential reference guide to using this completely rebuilt version of ANTLR, with its amazing new LL(*) parsing technology, tree construction facilities, StringTemplate code generation template engine, and sophisticated ANTLRWorks GUI development environment. Learn to use ANTLR directly from the author! ANTLR is a parser generator-a program that generates code to translate a specified input language into a nice, tidy data structure. You might think that parser generators are only used to build compilers. But in fact, programmers usually use parser generators to build translators and interpreters for domain-specific languages such as proprietary data formats, common network protocols, text processing languages, and domain-specific programming languages. Domain-specific languages are important to software development because they represent a more natural, high fidelity, robust, and maintainable means of encoding a problem than simply writing software in a general-purpose language. For example, NASA uses domain-specific command languages for space missions to improve reliability, reduce risk, reduce cost, and increase the speed of development. Even the first Apollo guidance control computer from the 1960s used a domain-specific language that supported vector computations. This book is the definitive guide to using the completely rebuilt ANTLR v3 and describes all features in detail, including the amazing new LL(*) parsing technology, tree construction facilities, StringTemplate code generation template engine, and sophisticated ANTLRWorks GUI development environment. You'll learn all about ANTLR grammar syntax, resolving grammar ambiguities, parser fault tolerance and error reporting, embedding actions to interpret or translate languages, building intermediate-form trees, extracting information from trees, generating source code, and how to use the ANTLR Java API.
Synthesis and bioreductive potential of a mono Noxide derivative of the alkylating agent chlorambucil (1994)

Chlorambucil N-oxide (CHLN-O) was synthesized and evaluated for in vitro bioreductive antitumor activity. A time-dependent hypoxic differential was observed when EMT6 cells were exposed to CHLN-O in the presence of rat liver microsomes and reducing equivalents. The cytotoxicity of the N-oxide was potentiated under hypoxia, and augmented further by a combination of low pH and hypoxia. Metabolic studies were also undertaken, which utilized previously described HPLC methodology for the analysis of CHLN-O loss from biological fluids. These demonstrated the requirement for microsomal enzymes and reducing equivalents, and also illustrated the time-dependent manner of CHLN-O loss from isolated microsomal preparations.
KIM – a semantic platform for information extraction and retrieval (2004)

The KIM platform provides a novel Knowledge and Information Management framework and services for automatic semantic annotation, indexing, and retrieval of documents. It provides a mature and semantically enabled infrastructure for scalable and customizable information extraction (IE) as well as annotation and document management, based on GATE.General Architecture for Text Engineering (GATE) (http://gate.ac.uk), leading NLP and IE platform developed at the University of Sheffield. Our understanding is that a system for semantic annotation should be based upon a simple model of real-world entity concepts, complemented with quasi-exhaustive instance knowledge. To ensure efficiency, easy sharing, and reusability of the metadata we introduce an upper-level ontology. Based on the ontology, a large-scale instance base of entity descriptions is maintained. The knowledge resources involved are handled by use of state-of-the-art Semantic Web technology and standards, including RDF(S) repositories, ontology middleware and reasoning. From a technical point of view, the platform allows KIM-based applications to use it for automatic semantic annotation, for content retrieval based on semantic queries, and for semantic repository access. As a framework, KIM also allows various IE modules, semantic repositories and information retrieval engines to be plugged into it. This paper presents the KIM platform, with an emphasis on its architecture, interfaces, front-ends, and other technical issues.
Impaired immunoglobulin synthesis by peripheral blood lymphocytes in systemic lupus erythematosus (1978)

Pokeweed mitogen (PWM)-induced immunoglobulin (Ig) synthesis by peripheral blood mononuclear cells (PBL) from 33 patients with systemic lupus erythematosus (SLE) was compared to that synthesized by PBL from 22 normal individuals. Short-term unstimulated culture of SLE-PBL immediately after separation from PB revealed Ig synthesis 4 times that of normal PBL. However, SLE-PBL had a depressed PWM-induced Ig synthetic response that was partially, but not totally, related to active disease and was not correctable by co-culture with normal lymphocyte populations. In both the short-term-unstimulated and the PWM-stimulated cultures, IgM was the major Ig class synthesized by normal PBL, while IgM synthesis by SLE-PBL was depressed more than the other Ig classes. These results can best be explained by a preactivated PBL population in SLE.
Conceptual and perceptual priming and dissociation in chronic posttraumatic stress disorder. (2010)

Cognitive models of posttraumatic stress disorder (PTSD) assert that memory processes play a significant role in PTSD (see e.g., Ehlers & Clark, 2000). Intrusive reexperiencing in PTSD has been linked to perceptual processing of trauma-related material with a corresponding hypothesized lack of conceptual processing. In an experimental study that included clinical participants with and without PTSD (N = 50), perceptual priming and conceptual priming for trauma-related, general threat, and neutral words were investigated in a population with chronic trauma-induced complaints as a result of the Troubles in Northern Ireland. The study used a new version of the word-stem completion task (Michael, Ehlers, & Halligan, 2005) and a word-cue association task. It also assessed the role of dissociation in threat processing. Further evidence of enhanced perceptual priming in PTSD for trauma stimuli was found, along with evidence of lack of conceptual priming for such stimuli. Furthermore, this pattern of priming for trauma-related words was associated with PTSD severity, and state dissociation and PTSD group made significant contributions to predicting perceptual priming for trauma words. The findings shed light on the importance of state dissociation in trauma-related information processing and posttraumatic symptoms.
A case study of parent child interaction therapy in an early intervention service (2014)

The Karitane Toddler Clinic is located in South Western Sydney, and services the entire Sydney metropolitan area. The Clinic was established in 2005 in response to an identified need for services to help families with young children displaying with significant behavioural problems. Parent-Child Interaction Therapy (PCIT) was the chosen model of therapy because of its focus on both relationship enhancement and behaviour management. This clinical case study describes and demonstrates the effectiveness of PCIT with a family who attended the clinic with a three year old boy. The presenting issues were severe tantrums, aggression and non-compliance. Method: PCIT was delivered over a fourteen week period with both parents participating. Results: At the end of the program, clinically and statistically significant improvements were seen in child behaviours. Conclusion: PCIT demonstrated to be an effective intervention for behaviours that are typically referred to the Karitane Toddler Clinic.
Super Capacitor Assisted Engine Starting System Modeling (2012)

A super capacitor is of large power density and discharge current,suitable for large current applications,especially high-energy pulse environment.In this paper,the super capacitor is applied to engine starting system,and the model of the system is set up,which is used to analyze the super capacitor assisted engine starting system.
Growth and magnetic studies of lattice expanded Pd in ultrathin Fe(001)/Pd(001)/Fe(001) structures (1990)

A new phase of Pd with an expanded lattice (5%) was grown on Fe(001). Ultrathin Fe/Pd and Pd/Fe bilayers and Fe/Pd/Fe trilayers were studied using ferromagnetic resonance and Brillouin scattering. Pd interlayers always couple the Fe layers ferromagnetically. For thicknesses up to four monolayers the Pd is ferromagnetic, in agreement with theory. One additional atomic layer of Pd destroys the ferromagnetism, but the Pd still exhibits a fluctuating magnetic moment partly polarized by the exchange field from adjacent Fe layers. The magnetic moments in the interfaces were determined from the ferromagnetic-resonance absorption intensities.
Deglycosylated human chorionic gonadotropin. An antagonist to desensitization and down-regulation of the gonadotropin receptor-adenylate cyclase system. (1983)

Human chorionic gonadotropin (hCG) was deglycosylated with anhydrous HF and compared with native hCG for binding and biological activity. The deglycosylated hormone (DG-hCG) had the same affinity as hCG for gonadotropin receptors in murine Leydig tumor cells (MLTC-1) but was less than 1% as potent as hCG in stimulating cyclic AMP production in these cells. Exposure of MLTC-1 cells for 30 min to hCG caused a desensitization of hCG-stimulated adenylate cyclase activity, whereas DG-hCG did not induce desensitization even after 4 h. hCG induced down-regulation of hCG receptors; by 4 h, 40% of the receptors had disappeared, whereas there was no receptor loss in cells exposed to DG-hCG for the same time. By 6 h, receptor down-regulation began to occur in the DG-hCG-treated cells and could be mimicked by exposing the cells to dibutyryl cyclic AMP or cholera toxin. Thus, the small increase in cyclic AMP generated by DG-hCG appears to result in some loss of receptors. Cells were incubated with iodinated hCG or DG-hCG for 30 min, washed, and incubated in fresh medium. Both bound ligands were degraded as measured by disappearance of cell-associated radioactivity and appearance of trichloroacetic acid-soluble label in the medium. The half-lives were 3 and 6 h for hCG and DG-hCG, respectively. Our results indicate that DG-hCG in contrast to hCG does not cause either rapid desensitization of hCG-stimulated adenylated cyclase or rapid down-regulation of hCG receptors. Therefore, receptor occupancy alone is insufficient to induce these phenomena.
Coupling to film waveguides with reusable plastic gratings (1976)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. S. Wei and C. C. Tan, "Coupling to film waveguides with reusable plastic gratings," Appl. Opt. 15, 289-290 (1976) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Formulation and<i>in vitro</i>evaluation of alfuzosin extended release tablets using directly compressible eudragit (2009)

The aim of the present study was the determination of formulation factors and the in vitro evaluation of an extended release dosage form of a freely soluble weakly basic drug (alfuzosin hydrochloride). Binary mixer of one hydrophilic polymer (hydroxypropylmethylcellulose) and one directly compressible Eudragit (RS PO) was used in tablets prepared by direct compression. The amounts of both polymers were taken as independent variables for the 3(2) Factorial design. The percent drug releases at 1, 6, 12 and 20 h were selected as responses. The main effect and interaction terms were quantitatively evaluated using mathematical model. Dissolution data were fitted to zero order, first order, and Higuchi's release kinetics to evaluate kinetic data. Both the diffusion and erosion mechanisms were responsible for drug release as shown by the power law. The release of Alfuzosin was prolonged for 20 h by binary mixer indicating the usefulness of the formulations for once daily dosage forms.
The recovery of optical flow for intelligent cruise control (2005)

This paper describes the analysis of optical flows computed on image sequences taken by a TV camera mounted on a car moving in usual outdoor sceneries. The vibration of the TV camera makes the numerical computation of temporal derivatives very noisy and the texture of the road image is very poor. Therefore differential techniques do not provide adequate results. By using correlation based techniques and by correcting the optical flows for shocks and vibrations, useful sequences of optical flows can be obtained. When the car is moving along a flat road and the optical axis of the TV camera is parallel to the ground, the motion field is expected to be quadratic and have a specific structure: as a consequence the egomotion can be estimated from this optical flow and information on the absolute velocity, angular velocity and radius of curvature of the moving vehicle can be obtained. In addition it is shown how to detect the relative motion caused by another moving vehicle, either approaching or overtaking. These results suggest that the optical flow can be successfully used by a vision system for assisting a driver in a vehicle moving in usual streets and motorways.
Safety, efficacy and patient acceptability of the contraceptive and non-contraceptive uses of the LNG-IUS (2009)

Intrauterine devices (IUDs) provide highly effective, long-term, safe, reversible contraception, and are the most widely used reversible contraceptive method worldwide. The levonorgestrel-releasing intrauterine system (LNG-IUS) is a T-shaped IUD with a steroid reservoir containing 52 mg of levonorgestrel that is released at an initial rate of 20 μg daily. It is highly effective, with a typical-use first year pregnancy rate of 0.1% - similar to surgical tubal occlusion. It is approved for 5 years of contraceptive use, and there is evidence that it can be effective for up to 7 years of continuous use. After removal, there is rapid return to fertility, with 1-year life-table pregnancy rates of 89 per 100 for women less than 30 years of age. Most users experience a dramatic reduction in menstrual bleeding, and about 15% to 20% of women become amenorrheic 1 year after insertion. The device's strong local effects on the endometrium benefit women with various benign gynecological conditions such as menorrhagia, dysmenorrhea, leiomyomata, adenomyosis, and endometriosis. There is also evidence to support its role in endometrial protection during postmenopausal estrogen replacement therapy, and in the treatment of endometrial hyperplasia.
Fourth Annual Meeting of the International Association of Labour History Associations (IALHI) (1974)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
The antimicrobial peptide BMAP-28 reduces lethality in mouse models of staphylococcal sepsis* (2004)

These results highlight the capacity of BMAP-28 to reduce the effects of components of the bacterial cells and suggest that it may be beneficial in the treatment of severe staphylococcal infections in concert with other antimicrobial agents.
Realizations of Generalized Warburg Impedance with RC Ladder Networks and Transmission Lines (1987)

A systematic way of constructing resistive‐capacitive ladder networks and transmission lines that have a generalized Warburg impedance has been developed, where is independent of the angular frequency , and . These realizations are believed to be useful for understanding the physical processes responsible for the above fractional‐power‐law dependence on frequency, which is often observed in interfacial and bulk ac response of many materials.
A method of multi-scale edge detection based on lifting scheme and fusion rule (2007)

Recently, the edge detection methods based on wavelet transform are mainly to extract image edge of high-frequency parts and to ignore some edge information of low-frequency ones. And the traditional wavelet transform is time and memory consuming. Therefore a method of multi-scale edge detection based on lifting scheme and fusion rule is proposed in this paper. This algorithm should be carried out first to decompose the source image by lifting scheme. Then the edges of high-frequency and low-frequency sub-images are extracted separately. The final edge image is obtained through the fusion rule of average energy. Experimental results showed that the algorithm has advantages of quick operation, efficient suppression of noise and high detection accuracy.
Wnt Signaling and Stem Cell Control (2008)

In many contexts, self-renewal and differentiation of stem cells are influenced by signals from their environment, constituting a niche. It is postulated that stem cells compete for local growth factors in the niche, thereby maintaining a balance between the numbers of self-renewing and differentiated cells. A critical aspect of the niche model for stem cell regulation is that the availability of self-renewing factors is limited and that stem cells compete for these factors (Fig. 1). Consequently, the range and concentrations of the niche factors are of critical importance. Now that some of the few self-renewing factors have become identified, aspects of the niche models can be tested experimentally. In this chapter, we address mechanisms of signal regulation that take place at the level of signal-producing cells, constituting a niche for stem cells. We emphasize the biochemical properties and posttranslational modifications of the signals, all in the context of Wnt signaling. We propose that these modifications control the range of Wnt signaling and have critical roles in establishing niches for stem cells in various tissues.
A comparison of Framingham and SCORE-based cardiovascular risk estimates in participants of the German National Health Interview and Examination Survey 1998 (2005)

Our results suggest that SCORE-HIGH may overestimate absolute risk of fatal coronary heart disease and cardiovascular disease in Germany and may need calibration. Furthermore, the limitations of current risk prediction tools emphasize the ongoing need for comprehensive, high-quality and timely European cohort data.
Synthesis and properties of high-molecular-weight step-growth polymers from bismaleimides (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and properties of high-molecular-weight step-growth polymers from bismaleimidesJerry E. WhiteCite this: Ind. Eng. Chem. Prod. Res. Dev. 1986, 25, 3, 395–400Publication Date (Print):September 1, 1986Publication History Published online1 May 2002Published inissue 1 September 1986https://pubs.acs.org/doi/10.1021/i300023a005https://doi.org/10.1021/i300023a005research-articleACS PublicationsRequest reuse permissionsArticle Views506Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Immunoglobulin M autoantibody to vimentin intermediate filaments. (1982)

Serum from a patient with the CREST Syndrome and systemic lupus erythematosus contained an IgM antibody that reacted at dilutions up to 1:800 with a fibrous cytoplasmic network in several epithelioid and fibroblastic cell lines. The antibody was shown by immunofluorescence microscopy to label a specific subset of cytoskeletal polymers, the intermediate filaments. The reactive antigen from this biochemically heterogeneous group of filaments was established as the 58,000-mol wt protein, vimentin: (a) the patient's serum reacts with a range of cell lines that contain intermediate filaments composed of vimentin, but not with cells whose intermediate filaments are composed of different protein subunits; (b) in PTK2 epithelioid cells the serum reacts with the class of filaments that coils around the nucleus after colchicine treatment (vimentin) and not with the filaments that remain dispersed after colchicine (prekeratin); and (c) the component of reactive cells that combines with the serum is shown by immunoelectrophoresis to be a 58,000-mol wt protein antigen. A similar antibody that binds intermediate filaments of PTK2 cells was encountered at lower titer in some sera from other patients with connective tissue diseases and in control sera. Previous routine antinuclear antibody assays using mouse liver or commercially prepared HEp-2 cells have failed to reveal anticytoskeletal antibodies in patient sera, perhaps due to inadequate presentation or preservation of cytoplasmic antigens.