gebhart/patrepeval huggingface dataset:
Interaction of sound with noise (1977)

A continuous 2.3-MHz signal of amplitude 0.09 atm was generated in water by a ceramic transducer. After passage through distances up to 0.7 m, the signal was detected by a second transducer and fed to a spectrum analyzer. The noise in the medium was provided by a mechanical noisemaker striking the metallic wall of the water-filled tank. The noise spectrum lay between 2–8 kHz, with component amplitudes up to 0.01 atm. The analyzed spectrum of the perturbed signal contained sidebands, shifted from the original signal frequency by 2–8 kHz, down approximately 70 dB from the primary signal level. Steps were taken to avoid interference from direct pickup of the audio noise signal by the transducer, by inserting a high-pass filter between the receiving transducer and the spectrum analyzer. Measurements of the sideband level were made as a function of the length of the interaction region, and an increase in the level was noted with increase in the path length. [Work supported by ONR.]
Allylic rearrangement oftrans-pinocarveol esters (1996)

The allylic rearrangement of trans-pinocarveol esters (I) to myrtenol esters (II), a reaction of interest in the chemistry of terpenes and cannabinoids, has been theoretically investigated. The intramolecular, cyclization-induced rearrangement results in equilibrium mixtures of the starting compounds and the products with the ratio of I vs. II in the equilibrium mixture being determined by their thermodynamic stabilities. The relative thermodynamic stabilities as reflected by calculated AM1 heats of formations (ΔHf) were determined for various I-II ester pairs. The study, in agreement with available experimental evidence, indicates that generally I, which contain an endocyclic double bond, are more stable and thus predominantly form following rearrangements. In two cases (acetate and pivalate) the stability is reversed. Calculations performed for similar structures, esters of 2-methylene cyclohexane-1-ol (IV) and 1-cyclohexene-1-methanol (V) gave similar results. Structural and electronic factors which might influence the stability of these compounds were examined. Interestingly, a correlation between thermodynamic stability and dipole moments was observed. © 1996 John Wiley & Sons, Inc.
Transendothelial migration of 27E10+ human monocytes (2000)

The myeloid-related proteins MRP8 (S100A8) and MRP14 (S100A9), two members of the S100 family of calcium-binding proteins, are co-expressed and form a cell-surface and cytoskeleton-associated heterodimer upon calcium mobilization which is recognized by the mAb 27E10. The heterodimer is abundantly expressed in the cytoplasm of granulocytes and a subpopulation of blood monocytes. Previously, we and others demonstrated endothelium-associated MRP8/14 in inflamed tissues in the vicinity of transmigrating leukocytes, suggesting a function of the proteins in this process. Here, we demonstrate that 27E10(+) cells represent a fast-migrating monocyte subpopulation which preferentially utilizes an ICAM-1-dependent mechanism. The following observations imply a function of MRP8/14 in the transmigration process: (i) higher secretion of MRP8/14 from 27E10(+) monocytes compared to 27E10(-) monocytes after interaction with activated endothelium, (ii) higher expression of CD11b on 27E10(+) compared to 27E10(-) monocytes, (iii) up-regulation of CD11b on 27E10(-) monocytes in the presence of MRP14 or MRP8/14 heterodimers but not MRP8 and (iv) active participation of MRP14 but not of MRP8 in transmigration as shown by blocking with respective antibodies. We show that the interaction of 27E10(+) monocytes with activated endothelium leads to MRP8/14 release which may account for the high MRP8/14 concentrations in body fluids of patients with acute or chronic inflammatory diseases. Released MRP8/14 may serve a function by enhancing CD11b expression and/or affinity in human monocytes and by participating in the transendothelial migration mechanism. Thus, MRP8/14 substantially contributes to the recruitment of monocytes to an inflammatory site.
Secretion of soluble complement inhibitors factor H and factor H-like protein (FHL-1) by ovarian tumour cells (2002)

We observed that the soluble complement regulators factor H and factor H-like protein were abundantly present in ascites samples as well as in primary tumours of patients with ovarian cancer. RT-PCR and immunoblotting analyses showed that the two complement inhibitors were constitutively produced by the ovarian tumour cell lines SK-OV-3 and Caov-3, but not PA-1 or SW626 cells. The amounts of factor H-like protein secreted were equal to those of factor H. This is exceptional, because e.g. in normal human serum the concentration of factor H-like protein is below 1/10th of that of factor H. In ascites samples the mean level of factor H-like protein (130+/-55 microg ml(-1)) was 5.5-fold higher than in normal human serum (24+/-3 microg ml(-1)). Ovarian tumour cells thus preferentially synthesise factor H-like protein, the alternatively spliced short variant of factor H. The tumour cells were found to bind both (125)I-labelled factor H and recombinant factor H-like protein to their surfaces. Surprisingly, the culture supernatants of all of the ovarian tumour cell lines studied, including those of PA-1 and SW626 that did not produce factor H/factor H-like protein, promoted factor I-mediated cleavage of C3b to inactive iC3b. Subsequently, the PA-1 and SW626 cell lines were found to secrete a soluble form of the membrane cofactor protein (CD46). Thus, our studies reveal two novel complement resistance mechanisms of ovarian tumour cells: (i) production of factor H-like protein and factor H and (ii) secretion of soluble membrane cofactor protein. Secretion of soluble complement inhibitors could protect ovarian tumour cells against humoral immune attack and pose an obstacle for therapy with monoclonal antibodies.
Toward a Unified Terminology of Processing Levels for Low-Cost Air-Quality Sensors (2019)

Low-cost sensor systems for measuring air quality have received widespread scientific and media attention over recent years. It has become an established technical methodology to improve the data quality of such sensor systems by co-locating them at traditional air quality monitoring stations equipped with reference instrumentation and field-calibrating individual units using various statistical techniques. Methods range from (multi-)linear regression to more complex statistical techniques, often using additional predictor variables such as air temperature or relative humidity, and occasionally data not actually measured by the sensor system itself (e.g. station observations or model output). Most of these techniques improve the level of agreement between sensor-derived data and reference data, in many cases eliminating issues such as chemical interferences and sensor-to-sensor variability. It is not always clear, however, the extent to which the data arising from such processing are still a true and independent measurement by the sensor system, or some blend of secondary data and model prediction. Noticing this development, Hagler et al. warned that some systems may use predictor variables for calibration in such a way that a line is crossed from justifiable and empirical correction of a known artifact to a method that is essentially a predictive statistical model. In addition, the processing steps that are carried out along the way are often not clearly communicated. The current lack of governmental or third-party standards for low-cost sensor performance and occasional lack of distinction between sensors and sensor systems further complicates data processing. Adding to the observations and recommendations made by Hagler et al. (2018)(2), we have further noticed that there is substantial and consistent confusion within both the scientific community and the interested public regarding the amount and type of processing applied to sensor data, and at what point derived data can be considered to have lost a meaningful link to quantitative traceability. The relevance of this issue to air quality sensors is significant since in most countries air quality targets and standards are set out in primary legislation and measured attainment of those targets has demanding traceability requirements. Clarity regarding the level of sensor data processing is important for evaluation of sensor technology, as well as correct use and interpretation of its data. To address this challenge we propose a unified terminology of processing levels for low-cost air quality sensor systems. A strict sequence of processing levels is already common practice in satellite remote sensing, where it has been in wide use across multiple agencies for decades.(1) We have adapted these levels and suggest a sequence of processing levels for data from low-cost air quality sensor systems (Table 1).
<title>Objective lens design for multiple-layer optical data storage</title> (1997)

Our group has investigated a number of finite conjugate aberration compensation systems in conjunction high numerical aperture objectives for multiple-layer optical data storage. The results of our investigation are that a Burch-type objective lens in conjunction with a Galilean telescope is a compact, simple and effective optical system for spherical aberration compensation.
Nitric oxide is the endothelium-derived relaxing factor in bovine pial arterioles. (1990)

The purpose of this study was to investigate the formation and action of a nitric oxide-related endothelium-derived relaxing factor in cerebral arteries of cattle. Pial artery segments (0.6-1 mm o.d.) were incubated in oxygenated (20%) Krebs-Henseleit buffer containing indomethacin. Addition of acetylcholine (0.1 microM) to rings precontracted by serotonin (0.1 microM) resulted in a significant (p less than 0.05) relaxation. This response disappeared after removal of the endothelium and addition of hemoglobin, a nitric oxide scavenger, and NG-monomethyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide biosynthesis. L-Arginine (10 microM) considerably attenuated the inhibitory action of NG-monomethyl-L-arginine. Relaxations induced by 3-morpholinosydnonimine and nitroglycerin (0.1 microM), two exogenous sources of nitric oxide, were unaffected by NG-monomethyl-L-arginine (10 microM) but abolished by hemoglobin. These data strongly suggest nitric oxide as the mediator of endothelium-derived relaxation in pial arteries of the cattle.
In Response (2015)

Journal of Orthopaedic Trauma 29(9):p e346-e347, September 2015. | DOI: 10.1097/01.bot.0000471279.12677.b8
Real-Time Observation of a Metastable State during the Phase Transition in Shocked Cadmium Sulfide (1998)

A method was developed to perform ps time-resolved electronic spectroscopy in shock wave experiments, and used to examine the initial stages of the phase transition in CdS. Changes in the electronic spectra were observed with 100 ps resolution in single crystals shocked to stresses between 3.6--8.8 GPa. The absorption results suggest that the initial stage of the transition is characterized by a very rapid transformation to an indirect band gap material. Along with earlier ns continuum data, these results make a strong case for a metastable state during the phase transition in shocked CdS.
Observation of granulocyte function during ex vivo thrombus formation for patients with ANKRD26-associated thrombocytopenia (2020)

ANKRD26-associated thrombocytopenia is a non-syndromic hereditary thrombocytopenia for which there are currently no formal diagnostic criteria. It is known that the probability of myeloid leukemia in patients with pathogenetic variants in the ANKRD26 gene significantly increases, however, studies of the functioning of granulocytes in this pathology have not been conducted. Aims: Analysis of the functioning of granulocytes and platelets during ex vivo thrombosis in patients with ANKRD26-associated thrombocytopenia. The study was approved by the Independent Ethics Committee of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology. Two patients and 10 healthy volunteers were included in the study. Intracellular signaling and platelet functional responses were observed by continuous flow cytometry. Ex vivo thrombus formation and granulocyte functioning were observed on a fluorescence microscope in parallel-plane flow chambers containing fibrillar collagen. Upon physiological activation (ADP, collagen) of patients’ platelets in vitro, there were no significant differences between the platelets of patients and healthy donors. However, the observed ex vivo size of platelet aggregates was significantly reduced in comparison with healthy donors and published data on patients with other thrombocytopenias. The observed number and activity (movement velocity) of granulocytes of patients was within normal values. However, significant morphological differences were observed for granulocytes of patients compared with granulocytes of healthy donors: there was an increased spreading of granulocytes, in particular, expressed in a large number of thin pseudopodia, as well as an increased curvature of the motion trajectories of granulocytes. Ex vivo observation of thrombus formation in patients with ANKRD26- associated thrombocytopenia, a significantly reduced thrombus size is observed with normal platelet activity and increased variability in the shape of granulocytes.
Wireless Technologies in Support of ISS Experimentation and Operations (2012)

Presentation reviews: (1) Wireless Communications (a) Internal (b) External (2) RFID (Radio Frequency Identification) (a) Existing and R&D (3) Wireless Sensor Networks (a) Existing and R&D (4) Ultra-Wide Band (UWB) (a) R&D
Primary structure of Golfingia gouldii hemerythrin. Interpeptide overlaps and sequences form chymotryptic peptides (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPrimary structure of Golfingia gouldii hemerythrin. Interpeptide overlaps and sequences form chymotryptic peptidesA. R. Subramanian, James W. Holleman, and Irving M. KlotzCite this: Biochemistry 1968, 7, 11, 3859–3867Publication Date (Print):November 1, 1968Publication History Published online1 May 2002Published inissue 1 November 1968https://doi.org/10.1021/bi00851a011RIGHTS & PERMISSIONSArticle Views26Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (864 KB) Get e-Alerts Get e-Alerts
Titanium honeycomb structure (1972)

A brazed titanium honeycomb sandwich system for supersonic transport wing cover panels provides the most efficient structure spanwise, chordwise, and loadwise. Flutter testing shows that high wing stiffness is most efficient in a sandwich structure. This structure also provides good thermal insulation if liquid fuel is carried in direct contact with the wing structure in integral fuel tanks.
High reliability InGaP/GaAs HBT (1998)

Excellent long term reliability InGaP/GaAs heterojunction bipolar transistors (HBT) grown by metalorganic chemical vapor deposition (MOCVD) are demonstrated. There were no device failures (T=10000 h) in a sample lot of ten devices (L=6.4 μm ×20 μm) under moderate current densities and high-temperature testing (J/sub c/=25 kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , V/sub ce/=2.0 V, Junction Temp =264/spl deg/C). The dc current gain for large area devices (L=75 μm ×75 μm) at 1 kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at a base sheet resistance of 240 ohms/sq (4×10/sup 19/ cm/sup -3/@700 /spl Aring/) was over 100. The dc current gain before reliability testing (L=6.4 μm ×10 μm) at 0.8 kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> was 62. The dc current gain (0.8 kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) decreased to 57 after 10000 h of reliability testing. The devices showed an f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> =61 GHz and f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> =103 GHz. The reliability results are the highest ever achieved for InGaP/GaAs HBT and these results indicate the great potential of InGaP/GaAs HBT for numerous low- and high-frequency microwave circuit applications. The reliability improvements are probably due to the initial low base current at low current densities which result from the low surface recombination of InGaP and the high valence band discontinuity between InGaP and GaAs.
Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway (2016)

Tle1 (transducin-like enhancer of split 1) is a corepressor that interacts with a variety of DNA-binding transcription factors and has been implicated in many cellular functions; however, physiological studies are limited. Tle1-deficient (Tle1(Δ/Δ)) mice, although grossly normal at birth, exhibit skin defects, lung hypoplasia, severe runting, poor body condition, and early mortality. Tle1(Δ/Δ) mice display a chronic inflammatory phenotype with increased expression of inflammatory cytokines and chemokines in the skin, lung, and intestine and increased circulatory IL-6 and G-CSF, along with a hematopoietic shift toward granulocyte macrophage progenitor and myeloid cells. Tle1(Δ/Δ) macrophages produce increased inflammatory cytokines in response to Toll-like receptor (TLR) agonists and lipopolysaccharides (LPS), and Tle1(Δ/Δ) mice display an enhanced inflammatory response to ear skin 12-O-tetradecanoylphorbol-13-acetate treatment. Loss of Tle1 not only results in increased phosphorylation and activation of proinflammatory NF-κB but also results in decreased Hes1 (hairy and enhancer of split-1), a negative regulator of inflammation in macrophages. Furthermore, Tle1(Δ/Δ) mice exhibit accelerated growth of B6-F10 melanoma xenografts. Our work provides the first in vivo evidence, to our knowledge, that TLE1 is a major counterregulator of inflammation with potential roles in a variety of inflammatory diseases and in cancer progression.
Efficient Nanosecond Two-Beam Coupling in Passive Organic Media (2017)

Efficient frequency-degenerate two-beam coupling is demonstrated in the nanosecond time scale with isotropic organic media using time-dependent self- and cross-phase modulation to generate the necessary phase shift for energy transfer.
Magnetic Resonance in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>α</mml:mi><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Fe</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (1954)

Magnetic resonance experiments performed on $\ensuremath{\alpha}{\mathrm{Fe}}_{2}{\mathrm{O}}_{3}$ confirm the existence of a highly anisotropic, weak ferromagnetism which disappears below -15\ifmmode^\circ\else\textdegree\fi{}C. The anisotropy energy has been studied as a function of orientation.
Ultrafast transient absorption spectroscopy of matrix-isolated perylene-related molecules (2005)

We report on experimental and theoretical investigations of matrix-isolated molecules of MePTCDI, presenting transient absorption spectra obtained with ultrafast pump-probe spectroscopy. The experimental transient absorption spectrum is consistently explained by highly-correlated quantum-chemical calculation methods.
Impact of the Invasive Brown Marmorated Stink Bug in North America and Europe: History, Biology, Ecology, and Management (2017)

The brown marmorated stink bug (BMSB), Halyomorpha halys (Stål), is an invasive pentatomid introduced from Asia into the United States, Canada, multiple European countries, and Chile. In 2010, BMSB populations in the mid-Atlantic United States reached outbreak levels and subsequent feeding severely damaged tree fruit as well as other crops. Significant nuisance issues from adults overwintering inside homes were common. BMSB is a highly polyphagous species with a strong dispersal capacity and high reproductive output, potentially enabling its spread and success in invaded regions. A greater understanding of BMSB biology and ecology and its natural enemies, the identification of the male-produced aggregation pheromone, and the recognition that BMSB disperses into crops from adjacent wooded habitats have led to the development of behavior-based integrated pest management (IPM) tactics. Much is still unknown about BMSB, and continued long-term collaborative studies are necessary to refine crop-specific IPM programs and enhance biological control across invaded landscapes.
Magnetic Properties in Phase IV of Ce<sub>0.8</sub>Nd<sub>0.2</sub>B<sub>6</sub>Studied by Muon Spin Relaxation (2002)

The magnetic properties of Ce 0.8 Nd 0.2 B 6 single crystals have been studied by muon spin relaxation (µSR). The lack of a clear muon spin precession in phase IV indicates that no commensurate long-range magnetic order is present in this phase. Moreover, the magnetic field dependence of the longitudinal field (LF) µSR measurement suggests the existence of the strong spin fluctuation in this phase.
Molecular mechanism of hepcidin deficiency in a patient with juvenile hemochromatosis (2007)

We describe a point mutation creating an additional ATG codon in the 5' untranslated region (UTR) of the HAMP gene, in a patient with juvenile hemochromatosis. By transient in vitro transfection studies, we provide evidence that the additional ATG is functional and prevents normal hepcidin production by inducing an aberrant translation initiation of the pre-hepcidin mRNA.
Immunobiology of chronic lymphocytic leukemia (2003)

B-cell chronic lymphocytic leukemia increasingly is being recognized as a useful model disease with which to study more general processes involved in the evolution of neoplastic disease. The accessibility of the tumor cells and the capacity to confirm their clonal relatedness allow for evaluation of the processes associated with neoplastic transformation and/or disease progression. Recent studies have provided fascinating insight into the potential pathogenesis and pathophysiology of this disease. In addition, features of leukemia cells have been identified that can distinguish subsets of patients that have different tendencies for disease progression. Gene expression studies have identified a relatively small number of genes that are differentially expressed between these subsets, allowing for focused attention on proteins that might contribute to the noted differences in clinical behavior. Finally, recognition that chronic lymphocytic leukemia cells depend upon specific microenvironmental growth and survival factors identifies novel targets for disease intervention. This article focuses on the reports of the past year that have contributed to these areas of active research on chronic lymphocytic leukemia, the most common adult leukemia in Western societies.