gebhart/patrepeval huggingface dataset:
Molecular Cloning and Characterization of a Novel Histone Deacetylase HDAC10 (2002)

The growing number of proteins controlled by reversible acetylation suggests the existence of a large number of acetyltransferases and deacetylases. Here, we report the identification of a novel class II histone deacetylase, HDAC10. Homology comparison indicates that HDAC10 is most similar to HDAC6. Both contain a unique, putative second catalytic domain not found in other HDACs. In HDAC10, however, this domain is not functional. This tandem organization of two catalytic domains confers resistance to the inhibitors trapoxin B and sodium butyrate, which potently inhibit the deacetylase activity of all other HDAC members. Thus, HDAC10 and HDAC6 share unusual structural and pharmacological characteristics. However, unlike HDAC6, which is normally a cytoplasmic deacetylase, HDAC10 resides in both the nucleus and cytoplasm. In the nucleus, when tethered to a promoter, HDAC10 represses transcription independent of its deacetylase activity, indicating that HDAC10 contains a distinct transcriptional repressor domain. These observations suggest that HDAC10 might uniquely play roles both in the nucleus, as a transcriptional modulator, and in the cytoplasm in an unidentified role. Together, our results identify HDAC10 as a novel deacetylase with distinct structure, pharmacology and localization and further expand the complexity of the HDAC family.
Handbook of Research on Cloud Infrastructures for Big Data Analytics (2014)

Clouds are being positioned as the next-generation consolidated, centralized, yet federated IT infrastructure for hosting all kinds of IT platforms and for deploying, maintaining, and managing a wider variety of personal, as well as professional applications and services.Handbook of Research on Cloud Infrastructures for Big Data Analytics focuses exclusively on the topic of cloud-sponsored big data analytics for creating flexible and futuristic organizations. This book helps researchers and practitioners, as well as business entrepreneurs, to make informed decisions and consider appropriate action to simplify and streamline the arduous journey towards smarter enterprises.
Turning waves and crustal reflection profiling (1997)

Abstract In the past, steeply dipping features were often recognized on seismic reflection profiles only from indirect evidence such as vertical offsets of cross-cutting structures. New imaging algorithms, as for example, turning wave migration have had dramatic success in delineating steep, even-overturned reflectors in sedimentary environments. Evaluation of the applicability of this technology to deep seismic recordings indicates that steep-dip and turning wave migration will have limited practicality, generally, in the imaging of basement features because of the weak velocity gradients involved and the corollary requirement for large recording offsets. A potential exception arises when the basement structures to be imaged lie beneath a significant thickness of relatively young (i.e., steep velocity gradient) sedimentary cover.
Multiprojector tiled display wall calibration with a camera (2005)

Recent developments in computer graphics hardware and distributed parallel rendering research have greatly improved the rendering capabilities of graphics workstations and PC clusters. However, the display resolution of monitors is still far from being enough, and thus become the bottleneck of visualization. Recently, more and more people are focusing on using multiple projectors to form a large display wall and provide high display resolutions. One essential problem of these kinds of systems is how to calibrate the projectors and make the whole display wall seamless and perfect. Traditional software calibration algorithms have three main problems: re-rendering and over illumination in overlapping regions, calibration being not general. In this paper, we introduce our multi-projector tiled display wall calibration system using a digital camera which mainly focuses on solving these three problems. For the first two, we make specific divisions to the overlapping regions basing on our dividing algorithms and each projector project only part of the overlapping images. Furthermore, we make some sub-division to each part and make the mosaic seamless. And for the last problem, we adopt the idea of the open source software VNC, and implement our calibration on the layer of Windows desktop, thus make the calibration process application independent.
Microstructure and mechanical properties of a new nickel-based single crystal superalloy (2020)

To obtain higher comprehensive mechanical properties while avoid the adverse effects of Re element on the microstructure and economy of the alloy, a Re-free nickel-based single crystal superalloy is developed based on the Rene N5 single crystal superalloy. The microstructure evolution, compression properties, tensile properties, deformation mechanism and fracture behaviour of the self-designed alloy are investigated. The experimental results show that after the complete heat treatment, cuboidal γ′ precipitates with high degree of regular morphology are formed. The size of γ′ precipitates is about 0.49 μm, and the volume fraction is approximately 61%, which are better than those for a conventional second generation single crystal superalloy. The alloy reaches its maximum compressive and tensile strength at 760 °C and shows excellent microstructure thermal stability and improved mechanical properties. The alloy has an obvious strain hardening stage when the temperature is lower than 760 °C, while the softening stage is not obvious. When the temperature reaches 850 °C, the stress–strain curve of the sample mainly shows that the variable stress increases abruptly at the beginning and then decreases immediately. The tensile fracture of a single crystal at medium and low temperature is characterized by a slip fracture with a certain plastic deformation. A high temperature tensile fracture is characterized by typical plastic deformation, and its mechanism is a creep fracture with a uniform deformation.
Determination of oxidized and reduced glutathione, by capillary zone electrophoresis, in <b><i>Brassica juncea</i></b> plants treated with copper and cadmium (2004)

A rapid method of capillary zone electrophoresis is described to determine the oxidized (GSSG) and reduced (GSH) form of glutathione in plant tissue. In order to separate both analytes in a fused-silica capillary, the pH and composition of the electrolyte solution were optimized. The electrolyte composition was 100 mmol/L, borate 25 mmol/L Tris, and 0.2% w/v metaphosphoric acid (MPA), pH 8.2. Some instrumental conditions used to run the samples were hydrostatic injection for 30 s, 30 kV applied voltage, and UV detection (185 nm) at 25 degrees C. Linearity and useful range obtained for the calibration curves were optimum, with correlation coefficients about 0.999 in the 0-120 micromol/L range. The migration time was highly reproducible, less than 5 min being afforded to run a sample. Electrolyte buffer and samples required a careful pH control for optimal separation of both analytes. This aspect constitutes a critical analytical step when acids are used in the procedure for sample preparation. Simultaneous analysis of GSH and GSSG may provide a useful tool for comparative studies of plants in order to select those species with a potential capacity for detoxification from toxic elements or those appearing promising from phytoremediation for these elements.
Efficient computation of absent words in genomic sequences (2008)

The new algorithm computes absent words for the human genome in 10 minutes on standard hardware, using only 2.5 Mb of space. This enables us to perform this type of analysis not only for the largest genomes available so far, but also for the emerging pan- and meta-genome data.
The Integrated Discrete-Event Systems Tool (2006)

A software tool for discrete-event systems problem-solving is described. The tool, called IDES, features a graphical user interface, allows input to be entered in a way that mimics pen-and-paper drawing, and allows output to LATEX and other formats. The current version of the tool does not yet include DES operations; rather it serves as a prototype for the software we are building that will incorporate DES operations
A policy-driven exception handling approach for service-oriented processes (2012)

Aiming to improving the exception handling capacity of BPEL process, this paper explores a policy-based exception handling method for service-oriented processes. The paper propose a policy-based exception handling description language EHPDL-P,and design a exception handling framework EHP-F to support the implementation mechanism of exception handling process based on EHPDL-P. Finally,through a case study from the domain of Manufacturing Execution System, this paper demonstrates the policy-based exception handling approach for service-oriented processes.
Similarity Digest Search: A Survey and Comparative Analysis of Strategies to Perform Known File Filtering Using Approximate Matching (2017)

Digital forensics is a branch of Computer Science aiming at investigating and analyzing electronic devices in the search for crime evidence. There are several ways to perform this search. Known File Filter (KFF) is one of them, where a list of interest objects is used to reduce/separate data for analysis. Holding a database of hashes of such objects, the examiner performs lookups for matches against the target device. However, due to limitations over hash functions (inability to detect similar objects), new methods have been designed, called approximate matching. This sort of function has interesting characteristics for KFF investigations but suffers mainly from high costs when dealing with huge data sets, as the search is usually done by brute force. To mitigate this problem, strategies have been developed to better perform lookups. In this paper, we present the state of the art of similarity digest search strategies, along with a detailed comparison involving several aspects, as time complexity, memory requirement, and search precision. Our results show that none of the approaches address at least these main aspects. Finally, we discuss future directions and present requirements for a new strategy aiming to fulfill current limitations.
Evaluation of a novel phantom-based neurosurgical training system (2014)

The training system is evaluated to be a suitable training tool for residents to become familiar with the complex procedures of autonomous neurosurgical planning and conducting of craniotomies in tumor surgeries. Becoming more confident is supposed to result in less error-prone and faster operation procedures and thus is a benefit for both physicians and patients.
A potassium thiocyanate extract vaccine prepared from Pasteurella multocida 3:A protects rabbits against homologous challenge (1987)

Potassium thiocyanate extracts of a virulent Pasteurella multocida 3:A rabbit isolate were prepared and used as a vaccine in rabbits. The extract contained protein, carbohydrate, hyaluronic acid, lipopolysaccharide, DNA, and RNA. The protein and lipopolysaccharide profiles of the extract were similar to those of the P. multocida cell membrane. Rabbits were vaccinated intranasally (i.n.) or intramuscularly (i.m.) four times at 1- or 3-week intervals and challenged i.n. with the homologous P. multocida 2 weeks after the last vaccination. Rabbits vaccinated with the extract by the i.n. route developed persisting serum immunoglobulin G (IgG) and nasal IgA antibodies, whereas rabbits immunized by the i.m. route produced persisting serum IgG and transient nasal IgA antibodies. The extract prevents the death of rabbits which were vaccinated by either route and challenged. Vaccination by the i.n. route in rabbits reduced the numbers of virulent P. multocida in nasal cavities and lungs and the prevalence and severity of rhinitis and pneumonia. These i.n.-vaccinated rabbits were also resistant to virulent P. multocida colonization in liver, spleen, uterus, and tympanic bullae. Similarly, i.m. vaccination in rabbits resulted in a reduction in the severity of rhinitis; the numbers of virulent P. multocida in lungs; and the prevalence of colonization in liver, spleen, uterus, and tympanic bullae. Vaccination by the i.n. route was superior to that by the i.m. route in that there was a significant reduction in the severity of pneumonia and numbers of virulent P. multocida in nasal cavities and lungs. Rabbits vaccinated with the extract without challenge showed no lesions.
Characteristics of silicon nitride after O/sub 2/ plasma surface treatment for pH-ISFET applications (2001)

Silicon nitride (Si3N4) sensing gate pH-ion-selective field effect transistors (ISFETs) were treated by 2.54-GHz microwave O2 plasma, the results show the ISFET sensitivity has an advantage up to 24% increment after the plasma treatment. Electron spectroscopy for chemical analysis (ESCA) is used to make sure that the plasma treatment is not just a native oxide cleaning procedure. The samples, which were immobilized with glutaraldehyde used as a bifunctional reagent and 3-aminopropyItriethoxysilane used as an adhesion promoter were studied. The binding force between the glucose oxidase and glutaraldehyde immobilized samples, and the element concentrations of nitrogen in 3-aminopropyltriethoxysilane immobilized samples are higher which were treated by plasma.
Pore Size Distributions in Porous Glasses:  A Computer Simulation Study (1998)

We have prepared a series of molecular models of porous glass using a recently developed procedure (Gelb, L. D.; Gubbins, K. E. Langmuir 1998, 14, 2097) that mimics the experimental processes that produce Vycor and controlled-pore glasses. We calculate nitrogen adsorption isotherms in these precisely characterized model glasses using Monte Carlo simulations. These isotherms are analyzed using the Barrett−Joyner−Halenda (BJH) method to yield pore size distributions, which are tested against exact pore size distributions directly measured from the pore structures. The BJH method yields overly sharp distributions that are systematically shifted (by about 1 nm) to lower pore sizes than those from our geometric method.
Mobile interface for adaptive image refinement using interactive evolutionary computing (2010)

Due to developing mobile devices and providing services like mobile blogs, people can easily share their thought and experience, at any place and any time. A picture is an important datum to record and share their thought and experience, while we can easily take pictures with a mobile device that has a camera in it. However, the quality is usually poor without image refinement. Many mobile devices provide a simply interface to improve the quality, but require knowledge of predefined filters or image enhancement to control the parameters. It causes the user to feel inconvenient in mobile environments for their real-time editing pictures. In this paper, we propose a novel image enhancement interface in consideration of the accessibility to the mobile environment and various constraints. A usability test with various images has been conducted to show its usefulness, and the proposed interface achieved better performance than the other through the SUS test.
Integrated analysis of directly captured microRNA targets reveals the impact of microRNAs on mammalian transcriptome (2020)

MicroRNA (miRNA)-mediated regulation is widespread, relatively mild but functionally important. It remains challenging to unequivocally identify miRNA targeted RNAs at a genomic scale and determine how changes in miRNA levels affect the transcriptome. Here, we captured individual miRNAs and their targeted RNA sites in wild-type, miR-200 family knockout and induced epithelial cells. We detected 1797 miRNAs interacting with 13,830 transcripts at 616,127 sites by sequencing 1,230,019 unique miRNA:RNA chimeras. Although mRNA sites that are bound by miRNAs and contain matches to seed sequences confer the strongest regulation, ∼40%-60% of miRNA bound regions do not contain seed matches. Different miRNAs have different preferences to seed matches and 3' end base-pairing. For individual miRNAs, the effectiveness of mRNA regulation is highly correlated with the number of captured miRNA:mRNA chimeras. Notably, elevated miR-200 expression robustly represses existing targets with little impact on newly recognized targets. Global analysis of directly captured mRNA targets reveals pathways that are involved in cancer and cell adhesion and signaling pathways that are highly regulated by many different miRNAs in epithelial cells. Comparison between experimentally captured and TargetScan predicted targets indicates that our approach is more effective in identifying bona fide targets by reducing false positive and negative predictions. This study reveals the global binding landscape and impact of miRNAs on the mammalian transcriptome.
Joint user scheduling, link adaptation and beam-forming for distributed antenna systems (2012)

This paper proposes a novel management algorithm for distributed antenna systems (DASs) that exploits the spatial diversity of the architecture in order to schedule (over the same frequency band) as many transmissions as possible with the most appropriate modulation and coding schemes (MCSs). This goal is achieved by means of a joint user scheduling, link adaptation and beam-forming algorithm that maximizes capacity. The adaptation scheme includes power control and adaptive modulation and coding (AMC). The core of the algorithm is based on an iterative least squares (LS) optimization, where power levels and beam-forming vectors are jointly calculated so as to comply with a different SINR (signal-to-interference-plus-noise ratio) for each scheduled user. This SINR level ensures the transmission of the selected MCS with a given value of BLER (block error rate). In comparison with previous approaches, the proposed scheme ensures not only the existence of a solution for systems with power constraints, but it also allows for a smooth integration of scheduling and AMC schemes. Each LS stage is solved by the method of gradient steepest descent, whose convergence speed is improved by reusing the solution of previous LS stages. An iterative method is also proposed for a more efficient calculation of inter-cell interference. Imperfect channel state information is used in all simulations. Results show considerable throughput gains when compared to previous solutions.
Jointly Modeling Aspects and Opinions with a MaxEnt-LDA Hybrid (2010)

Discovering and summarizing opinions from online reviews is an important and challenging task. A commonly-adopted framework generates structured review summaries with aspects and opinions. Recently topic models have been used to identify meaningful review aspects, but existing topic models do not identify aspect-specific opinion words. In this paper, we propose a MaxEnt-LDA hybrid model to jointly discover both aspects and aspect-specific opinion words. We show that with a relatively small amount of training data, our model can effectively identify aspect and opinion words simultaneously. We also demonstrate the domain adaptability of our model.
Contribution of sequence variation in<i>Drosophila</i>actins to their incorporation into actin-based structures in vivo (2005)

Actin is a highly conserved protein important for many cellular functions including motility, contraction in muscles and intracellular transport. Many eukaryotic genomes encode multiple actin protein isoforms that differ from each other by only a few residues. We addressed whether the sequence differences between actin paralogues in one species affect their ability to integrate into the large variety of structures generated by filamentous actin. We thus ectopically expressed all six Drosophila actins as fusion proteins with green fluorescent protein (GFP) in a variety of embryonic, larval and adult fly tissues. We found that each actin was able to integrate into most actin structures analysed. For example, in contrast to studies in mammalian cells, the two Drosophila cytoplasmic actins were incorporated into muscle sarcomeres. However, there were differences in the efficiency with which each actin was incorporated into specific actin structures. The most striking difference was observed within the Z-lines of the sarcomeres: one actin was specifically excluded and we mapped this feature to one or both of two residues within the C-terminal half of the protein. Thus, in Drosophila, the primary sequence of different actins does affect their ability to incorporate into actin structures, and so specific GFPactins may be used to label certain actin structures particularly well.
Enhancement of Fracture Healing With Bone Stimulators (2002)

Summary Problems with fracture healing are not uncommon. Bone stimulators apply an electromagnetic or ultrasonic signal to the bone to promote healing. Both in vitro and in vivo studies demonstrate effects on bone cell physiology and fracture healing. Direct current stimulates bone formation in tissue and organ culture experiments and in animal studies in a dose-response fashion. Electromagnetic fields alter the effects of hormones on the cell membranes, and increase production of growth factors and receptors, affect calcium flux across membranes, and stimulate endothelial cell proliferation and capillary formation. Animal studies show that pulsed electromagnetic fields speed bone repair and prevent disuse osteopenia. Low intensity ultrasound promotes cartilage calcification and alters gene expression. Clinical series suggest that electromagnetic stimulation is equivalent to bone grafting for initial treatment of long bone nonunion, and better in cases of failed surgery. Prospective, randomized, double blind studies show that noninvasive electrical stimulation is an effective treatment for long bone nonunion, and that ultrasonic treatment speeds the healing of fresh fractures.
The Oxidatic Activity of Horseradish Peroxidase (1963)

1 Reactions in which hydrogen peroxide is the electron acceptor will be referred to as peroxidations or peroxidatic reactions; those in which oxygen is the electron acceptor, as oxidations or oxidatic reactions.* The abbreviation used is: MN&H*, 2-methyl-1,4-naphthohydroquinone (menadiol) ; MN& denotes the corresponding quinone.3 The compounds oxidized in the oxidatic reactions of peroxidases will be referred to as electron donors for the reduction of oxygen rather than as substrates of the enzyme.
Photocatalytic Production of Organic Compounds from CO and H <sub>2</sub> O in a Simulated Martian Atmosphere (1971)

[(14)C]CO(2) and [(14)C]organic compounds are formed when a mixture of [(14)C]CO and water vapor diluted in [(12)C]CO(2) or N(2) is irradiated with ultraviolet light in the presence of soil or pulverized vycor substratum. The [(14)C]CO(2) is recoverable from the gas phase, the [(14)C]organic products from the substratum. Three organic products have been tentatively identified as formaldehyde, acetaldehyde, and glycolic acid. The relative yields of [(14)C]CO(2) and [(14)C]organics are wavelength- and surface-dependent. Conversion of CO to CO(2) occurs primarily at wavelengths shorter than 2000 A, apparently involves the photolysis of water, and is inhibited by increasing amounts of vycor substratum. Organic formation occurs over a broad spectral ranger below 3000 A and increases with increasing amounts of substratum. It is suggested that organic synthesis results from adsorption of CO and H(2)O on surfaces, with excitation of one or both molecules occurring at wavelengths longer than those absorbed by the free gases. This process may occur on Mars and may have been important on the primitive earth.