gebhart/patrepeval huggingface dataset:
Intensification of pressure swing adsorption processes (1990)

Abstract Scaling rules have been developed which are able to change the dimension of a pressure swing adsorption plant keeping its main performance constant. Such scaling rules result from a system of algebraic equations which arises by constraining the solution of a fairly general dimensionless mathematical model to be the same in the old and new plant configuration. Different heat and mass transfer mechanisms, purification, and multicomponent bulk separation processes, both isothermal and nonisothermal, have been considered. Furthermore, the influence of different equilibrium isotherms and the main practical limitations have been discussed. The application of these rules shows that column size can be reduced significantly by using smaller particles in shorter beds with rapid cycles.
A High Polymerization of Ethylene with Zirconium Phosphate-AlEts Catalyst (1964)

ジルコニウムリン酸塩-トリエチルアルミニウム系触媒によるエチレン高重合反応の研究を行ない,ジルコニウムリン酸塩の焼成によるその構造変化と重合活性物質との関連性について,次の結果をえた。用いたジルコニウムリン酸塩は,二水素リン酸ジルコニウムから焼成によって無定型のピロリン酸ジルコニウムに変化し,その量に応じて重合活性が大となる。この割合は焼成温度の上昇とともに大きくなるが,700℃以上の温度では,表面積の低下により重合活性が減少する。重合活性物質は,固体上のZr→OとAlEt3の相互作用によって生成するものと推論した。
A LTE RX front-end with digitally programmable multi-band blocker cancellation in 28nm CMOS (2017)

This paper presents a LTE receiver front-end with a feedback digital filter in the baseband to perform multiband blocker cancellation. The programmable filter provides 34.9dB attenuation of TX leakage and variable attenuation of an additional blocker anywhere in the frequency range 17.5MHz-107.5MHz. The receiver front-end operates at 1.8GHz with a noise figure of 3.9dB, IIP3 of -5dBm, and consumes only 20.4-37.5mW, the lowest among state-of-the-art designs.
Adsorption and reaction of iodine and methyl iodide with uranium monocarbide surfaces (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdsorption and reaction of iodine and methyl iodide with uranium monocarbide surfacesJ. G. Dillard, H. Moers, H. Klewe-Nebenius, G. Kirch, G. Pfennig, and H. J. AcheCite this: J. Phys. Chem. 1984, 88, 22, 5345–5352Publication Date (Print):October 1, 1984Publication History Published online1 May 2002Published inissue 1 October 1984https://pubs.acs.org/doi/10.1021/j150666a048https://doi.org/10.1021/j150666a048research-articleACS PublicationsRequest reuse permissionsArticle Views109Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Note: Microelectromechanical systems Coulter counter for cell monitoring and counting (2010)

This note describes the design, fabrication, and testing of a novel microelectromechanical systems Coulter counter. The Coulter counter will be used to detect and monitor impedance changes of cells as a function of time in response to different experimental extracellular environments. The device consists of SU-8 (negative photoresist) microchannels, vertical electroplated electrodes, polydimethylsiloxane cover, and is divided into a passive mixing region, a focusing region using negative dielectrophoretic forces, and a measuring region defined by multiple electroplated electrode pairs. The devices were tested using both microbeads in saline water and fibroblast cells in phosphate buffered saline solution. The results show that the proposed microsystem is capable of monitoring impedance of cells at different positions along the Coulter microchannel.
Different Erythromycin Resistance Mechanisms in Group C and Group G Streptococci (1998)

Different mechanisms of erythromycin resistance predominate in group C and G streptococcus (GCS and GGS, respectively) isolates collected from 1992 to 1995 in Finland. Of the 21 erythromycin-resistant GCS and 32 erythromycin-resistant GGS isolates, 95% had the mefA or mefE drug efflux gene and 94% had the ermTR methylase gene, respectively.
2009 George L. Duff Memorial Lecture—The Toll of Toll-Like Receptors on Atherosclerosis (2009)

Atherosclerosis is an inflammatory disease. Atherosclerotic lesions are foci of vessel wall inflammation. Lesions begin, very early in life, as fatty streaks, progressing to vulnerable obstructive lesions under the influence of both genetic and lifestyle insults. During a human lifetime that elapses between fatty streak formation and overt disease, many events can accelerate lesion progression. Genetic diseases, notably hypercholesterolemia, lead to severe disease. Lifestyle choices, which include smoking, obesity, and excessive quiescence, also make significant contributions to disease progression. Finally, inflammatory disease elsewhere in the body, ranging from periodontitis to autoimmune disease, can have an exacerbating effect as well. Toll-like receptors are a key mechanistic link between chronic inflammation and atherosclerosis. However, the factors that promote atherosclerotic lesion development do not do so uniformly throughout the arterial tree. Lesions form first at sites of disturbed blood flow. Such sites are at vessel bifurcations and at the lesser curvature of the aortic arch. These sites display an inflamed phenotype even in the absence of any other exacerbating disease factors. This is due to the altered flow patterns at these sites within the aortic arch and the endothelial cell response to this disturbed flow. The biochemical mechanisms by which endothelial cells detect flow patterns are beginning to be understood. However, no particular atherosclerosis risk factor has been identified that would promote a proinflammatory phenotype only at arterial bifurcations and the lesser curvature of the aortic arch. Toll-like receptors (TLRs) may provide a clue. TLRs are initiators of inflammation driven by agonists that can be either endogenous, such as sterile tissue damage, or exogenous, such as pathogens. Given the vicissitudes of daily life, TLRs likely initiate appropriate inflammatory responses every day. The majority of these are beneficial, promoting healing and homeostasis, but occasionally, inappropriate TLR activation causes pathology. Bone marrow transplantation experiments demonstrate that leukocytes do not participate in the early atheroprotective inflammatory responses observed in TLR-deficient mice exposed to only endogenous agonists, but do participate in the proatherogenic responses to an exogenous agonist. We hypothesize that the exacerbation of disease progression mediated by endogenous activation of TLR receptors in endothelial cells is a disease of the arteries that is an “inside-out” (blood–lumen–endothelial cell–intima) phenomenon. In contrast, the accelerated disease mediated by exogenous activation of TLR receptors on circulating leukocytes is an “inside-out” and an “outside-in” disease phenomenon (leukocytes–vasa vasorum–adventia to media).
ChemInform Abstract: Poly(phosphoester)s: A New Platform for Degradable Polymers (2015)

Abstract Review: [77 refs.
Effect of rosuvastatin on dyslipidemia and other parameters associated with metabolic syndrome in Saudi patients (2016)

Rosuvastatin markedly improved atherogenic dyslipidemia of MS.
Abstract 12529: The Association of the Different Vitamin D Metabolites to Death, Myocardial Infarction, Heart Failure, and Stroke: Results From the Intermountain Heart Collaborative Study (2016)

Introduction: Many epidemiological studies have shown that total circulating levels of 25-hydroxyvitamin D (VitD) are strongly associated with poor cardiovascular (CV) outcomes. However, 85-90% of circulating VitD is bound to vitamin D binding protein (BP) or albumin, and levels obtained may not be truly reflective of the VitD available to act on target cells. Whether more direct markers of VitD activity such as bioavailable VitD (BIO) or free VitD (FREE) are more effective in predicting future CV risk is not known. Hypothesis: The more direct markers of VitD activity are more strongly associated with adverse CV outcomes. Methods: Patients (N=4285) undergoing angiography for CAD determination were studied. Levels of VitD, BP and albumin were directly measured and BIO and FREE were calculated using standard formulae. Multivariable Cox hazard regression was utilized to determine quartile (Q) associations with death (all-cause, CAD, and cardiac), MI, HF hospitalization, and stroke. Median length of follow-up was 10.9 years. Results: Patients averaged 64±12 years, 66% male, 23% diabetic, 90% Caucasian, and 70% diagnosed with CAD. Median and interquartile ranges of VitD, BP, BIO, and FREE were 24.9 (20.0, 28.7) ng/mL, 168.3 (103.7, 245.9) ug/mL, 7.1 (3.9, 15.2) ng/mL, and 15.7 (9.2, 33.3) pg/mL, respectively. Multivariable hazard ratios for the various metabolites with each of the outcomes are shown in Table. BP was not associated with any of the outcomes. VitD, BIO, and FREE were all associated with death (all-cause, CAD, and cardiac). VitD continued to be significantly associated with HF hospitalization and stroke, with its association to MI being attenuated. Conclusion: Among this predominately Caucasian population, VitD was found to consistently be the strongest predictor of all of the outcomes over BP, BIO, and FREE. Future studies are needed to evaluate whether obtaining thresholds of VitD levels are associated with a reduction in CV risk.
Effects of environment and composition on degradation of guayule rubber (1996)

Bales of antioxidant-stabilized guayule rubber underwent significant losses in bulk viscosity when stored under ambient conditions at an Arizona processing facility. Previous work implicated the unsaturated fatty acid esters present in entrained resin as promoters of such degradation. Aging studies as functions of storage temperature and unsaturated acid ester content were carried out on both bulk rubber and rubber-resin solution (miscella) for cultivar AZ-101. The rate of thermooxidative degradation, determined as a function of Mooney viscosity, was increased by the addition of unsaturated ester. Anaerobic degradation was not affected in this way. The activation energy of chain thermolysis was found to be 116 ± 6 kJ/mol (28 ± 1 kcal/mol). At temperatures above 60°C, chain recombination successfully competed with chain scission in lower viscosity rubber. The rate of thermoox-idative degradation was substantially higher in a typical process miscella. A hindered amine antioxidant significantly reduces chain scission under these conditions. © 1996 John Wiley & Sons, Inc.
Atypical Adenomatous Hyperplasia (Adenosis) of the Prostate: DNA Ploidy Analysis and Immunophenotype (2005)

Atypical adenomatous hyperplasia (AAH) of the prostate is a microscopic proliferation of small acini that may be mistaken for adenocarcinoma. Although some data suggest that AAH is associated with adenocarcinoma arising in the transition zone, the clinical significance of this lesion is uncertain. Therefore we studied the DNA ploidy pattern and immunophenotype of AAH as compared with nodular hyperplasia and well-differentiated adenocarcinoma in 23 formalin-fixed, paraffin-embedded, whole-mounted retropubic prostatectomies. Representative sections were immunostained for keratin 34beta-E12, chromogranin, bcl-2, c-erbB-2, ki67-MIB1, and factor VIII (microvessel density). DNA ploidy was determined by image analysis and Feulgen-stained sections. There were rare scattered immunoreactive cells for chromogranin, bcl-2, and c-erbB-2 in nodular hyperplasia and AAH (mainly in the basal cell compartment) and in carcinoma. The ki67-MIB1 labeling index was different between nodular hyperplasia and AAH (p<0.001) and carcinoma (p=0.003) but not between AAH and carcinoma (p=0.203). Microvessel density was different between AAH and carcinoma (p=0.001) but not between nodular hyperplasia and AAH (p=0.105) or carcinoma (p=0.0820). All foci of nodular hyperplasia, AAH, and carcinoma were diploid. Ploidy status and our selected panel of antibodies did not discriminate among these 3 entities reliably.
Tissue factor as a novel marker for detection of circulating cancer cells (2010)

Tissue factor (TF) is a molecular marker that is up-regulated in cancer cells and aids tumoral dissemination. Our purpose was to develop a nested RT-PCR strategy against TF for detecting blood-borne tumour cells. Our method detected TF expression in a minimum of 1.5 pg total RNA from MCF7 cells. A preliminary study in blood samples from 16 advanced breast carcinoma patients showed that 80% of patients with high TF load progressed and died, while only 18% with low TF load showed the same behaviour. Kaplan-Meier analysis confirmed worse overall survival in patients with high TF load.
Multicentric reticulohistiocytosis presenting with a rash and arthralgia (2002)

A case of multicentric reticulohistiocytosis in a 53-year-old woman with a history of generalized cutaneous eruptions followed by arthralgia is presented. A thorough malignancy screen was performed with negative results. Treatment was commenced with oral prednisone 20 mg daily, which rapidly resulted in marked improvement of joint symptoms and resolution of self-perceived functional disability. As there was little improvement of her rash, oral azathioprine was added at 100 mg daily. Both drugs were well-tolerated and the patient was discharged from hospital on these medications. Two months later the azathioprine was reduced to 50 mg per day orally, following a small rise in hepatic transaminases. Within 4 months there had been dramatic improvement in the rash and cutaneous nodules with complete remission of the arthralgia and pruritus. During this time the oral prednisone had gradually been decreased to 10 mg daily. To date only the periungual nodules persist.
Method for Determination of Oxygen-18 Content of Inorganic Phosphate (1958)

The reaction of inorganic phosphate and mercuric cyanide at temperatures from 240° to 300°C leads to the quantitative conversion of the phosphate oxygens to carbon dioxide. This report describes the proper conditions for the advantageous use of this reaction for the determination of the oxygen isotope composition of the inorganic phosphate.
Application of Participant-based Approach for Residential Air Quality Monitoring (2010)

PP-30-193 Background/Aims: Exposure to hazardous pollutants during pregnancy may cause critical reproductive health outcomes. Collecting residential exposure data has been hampered by the cost and participant burden in health studies of indoor air pollution. This study utilized a participant-based approach to measure residential volatile organic compounds concentration. Methods: Four hundred thirteen women were recruited from 3 major hospitals in Seoul and 411 agreed to participate. A passive sampler (OVM 3500, 3M) with instruction and a questionnaire were given to the participants. They were asked to deploy the sampler for 3 to 5 days and return by pre-stamped envelope. Results: A total of 345 participants (83.9%) completed the air sampling and returned the sampler and 16.1% did not return either the sampler or questionnaire. Among the 345 participants who completed sampling, 3 participants returned the sampler but took more than 2 months and 22 participants exposed the sampler for more than 8 days. Among the returned samplers, 92.8% complied with our monitoring quality criteria. The compliance rates were 93.3%, 91.1%, and 94.4% in the 3 hospitals. The mean total volatile organic compounds concentration was 523 μg/m3; 38.4% of residential level exceeded standard of 500 μg/m3 for public use indoors in Korea. The mean concentrations of benzene, toluene, ethyl benzene, and xylenes were 1.0 μg/m3, 53.0 μg/m3, 4.8 μg/m3, and 7.7 μg/m3, respectively. Conclusion: The findings suggest that participant-based sampling approach may be a feasible and cost-effective alternative to residential exposure assessment.
Ribofuranosyl Triazolone:  A Natural Product Herbicide with Activity on Adenylosuccinate Synthetase Following Phosphorylation (2000)

2,4-Dihydro-4-(beta-D-ribofuranosyl)-1,2,4(3H)-triazol-3-one (2) was identified as the principal phytotoxic component of a fermentation broth derived from an Actinomadura. The compound is a new natural product, but known by synthesis. Broad-spectrum herbicidal activity was demonstrated in greenhouse tests. Metabolite reversal studies suggested the target site was adenylosuccinate synthetase, which was confirmed by direct measurement of the activity of the 5'-phosphorylated derivative on the isolated enzyme.
CD4 and BST-2/Tetherin Proteins Retro-translocate from Endoplasmic Reticulum to Cytosol as Partially Folded and Multimeric Molecules (2013)

CD4 and BST-2/Tetherin are cellular membrane proteins targeted to degradation by the HIV-1 protein Vpu. In both cases proteasomal degradation following recruitment into the ERAD pathway has been described. CD4 is a type I transmembrane glycoprotein, with four extracellular immunoglobulin-like domains containing three intrachain disulfide bridges. BST-2/Tetherin is an atypical type II transmembrane glycoprotein with an N-terminal transmembrane domain and a C-terminal glycophosphatidylinositol anchor, which dimerizes through three interchain bridges. We investigated spontaneous and Vpu-induced retro-translocation of CD4 and BST-2/Tetherin using our novel biotinylation technique in living cells to determine ER-to-cytosol retro-translocation of proteins. We found that CD4 retro-translocates with oxidized intrachain disulfide bridges, and only upon proteasomal inhibition does it accumulate in the cytosol as already reduced and deglycosylated molecules. Similarly, BST-2/Tetherin is first exposed to the cytosol as a dimeric oxidized complex and then becomes deglycosylated and reduced to monomers. These results raise questions on the required features of the putative retro-translocon, suggesting alternative retro-translocation mechanisms for membrane proteins in which complete cysteine reduction and unfolding are not always strictly required before ER to cytosol dislocation.
Experimental verification of calculated models for sensitivity adjustment of angle-beam transceivers for ultrasonic testing (1998)

Mit dem in der vorliegenden Arbeit experimentell verifizierten Rechenmodell koennen Schallfelder, Fokusdaten und Einschallwinkel der unterschiedlichsten SE-Pruefkoepfe mit einer hohen Genauigkeit berechnet werden. Probleme, die bei der Berechnung der Fokusdaten von Kriechwellenpruefkoepfen bezueglich der unterbewerteten Echoamplituden von direkt unter der Oberflaeche liegenden Reflektoren auftreten, scheinen durch eine Modifikation des Rechenprogramms loesbar zu sein. Hierzu muss die Wirksamkeit des im Rechenmodell integrierten Kriechwellenanteils bei geringer Reflektortiefe erhoeht werden. Sollte die Genauigkeit der berechneten Einschallwinkel im Tiefenbereich von mehr als 10 mm Tiefe nicht den Erwartungen entsprechen, so kann durch eine Verbesserung der vom Rechenmodell berechneten Schallwege deren Genauigkeit moeglicherweise weiter verbessert werden. Da die Abweichungen jedoch in einem Tiefenbereich auftreten fuer welchen die verwendeten SE-Pruefkoepfe nicht entwickelt worden sind, kann dieser Bereich ebenso von der Betrachtung ausgeschlossen werden. (orig.)
Clustering gene expression data using Coxian phase-type survival (2010)

The paper is concerned with modeling gene expression data of Acute Myeloid Leukemia patients and their survival. Of particular interest is the development of a clustering approach that will identify clusters of patients that have similar gene expression characteristics. This paper considers one such approach based on the Coxian phase-type distribution which proved to be an adequate representation for the patient survival distribution. If such an approach were introduced it would facilitate better patient management and hence allow the most suitable care plan for the different clusters of patients. This will not only have financial benefit but will provide a better quality of service to the patient who will no longer have to undergo ineffective treatments that may have damaging side effects.
Progress towards Automated Kepler Scientific Workflows for Computer-aided Drug Discovery and Molecular Simulations (2014)

We describe the development of automated workflows that support computed-aided drug discovery (CADD) and molecular dynamics (MD) simulations and are included as part of the National Biomedical Computational Resource (NBCR). The main workflow components include: file-management tasks, ligand force field parameterization, receptor-ligand molecular dynamics (MD) simulations, job submission and monitoring on relevant high-performance computing (HPC) resources, receptor structural clustering, virtual screening (VS), and statistical analyses of the VS results. The workflows aim to standardize simulation and analysis and promote best practices within the molecular simulation and CADD communities. Each component is developed as a stand-alone workflow, which allows easy integration into larger frameworks built to suit user needs, while remaining intuitive and easy to extend.
Free network visible network (2005)

This artistic project uses the possibilities of the new technologies to create new landscapes in the public space by means of the visualization of the data that flow between digital networks. It changes our perception of the world with the invisible meanings that are around us.
DAPT-Induced Intracellular Accumulations of Longer Amyloid β-Proteins:  Further Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase (2006)

Gamma-secretase cleaves the transmembrane domain of beta-amyloid precursor protein at multiple sites. These are referred to as gamma-, zeta-, and epsilon-cleavages. We showed previously that DAPT, a potent dipeptide gamma-secretase inhibitor, caused differential accumulations of longer amyloid beta-proteins (Abetas) (Abeta43 and Abeta46) in CHO cells that are induced to express the beta C-terminal fragment (CTF). To learn more about the cleavage mechanism by gamma-secretase, CHO cell lines coexpressing betaCTF and wild-type or mutant presenilin (PS) 1/2 were generated and treated with DAPT. In all cell lines treated with DAPT, as the levels of Abeta40 decreased, Abeta46 accumulated to varying extents. In wild-type PS1 or M146L mutant PS1 cells, substantial amounts of Abeta43 and Abeta46 accumulated. In contrast, this was not the case with wild-type PS2 cells. In M233T mutant PS1 cells, significant amounts of Abeta46 and Abeta48 accumulated differentially, whereas in N141I mutant PS2 cells, large amounts of Abeta45 accumulated concomitantly with a large decrease in Abeta42 levels. Most interestingly, in G384A mutant PS1 cells, there were no significant accumulations of longer Abetas except for Abeta46. Abeta40 was very susceptible to DAPT, but other Abetas were variably resistant. Complicated suppression and accumulation patterns by DAPT may be explained by stepwise processing of betaCTF from a zeta- or epsilon-cleavage site to a gamma-cleavage site and its preferential suppression of gamma-cleavage over zeta- or epsilon-cleavage.