gebhart/patrepeval huggingface dataset:
Cell proteins bind to multiple sites within the 5' untranslated region of poliovirus RNA. (1989)

The 5' noncoding region of poliovirus RNA contains sequences necessary for translation and replication. These functions are probably carried out by recognition of poliovirus RNA by cellular and/or viral proteins. Using a mobility-shift electrophoresis assay and 1,10-phenanthroline/Cu+ footprinting, we demonstrate specific binding of cytoplasmic factors with a sequence from nucleotides 510-629 within the 5' untranslated region (UTR). Complex formation was also observed with a second sequence (nucleotides 97-182) within the 5' UTR. These two regions of the 5' UTR appear to be recognized by distinct cell factors as determined by competition analysis and the effects of ionic strength on complex formation. However, both complexes contain eukaryotic initiation factor 2 alpha, as revealed by their reaction with specific antibody.
Determining the effective system damping of highway bridges. (2009)

This project investigates four methods for modeling modal damping ratios of short-span and isolated concrete bridges subjected to strong ground motion, which can be used for bridge seismic analysis and design based on the response spectrum method. The four methods are: complex modal analysis (CMA), neglecting off-diagonal elements in damping matrix method (NODE), composite damping rule (CDR), and optimization in time domain and frequency domain (OPT) and applied to a short-span bridge and an isolated bridge. The results show that the NODE method is the most efficient and the conventional assumption of 5 percent modal damping ratio is too conservative for shortspan bridges when energy dissipation is significant at the bridge boundaries. From the analysis of isolated bridge case, the effective system damping is very close to the damping ratio of isolation bearing.
Data warehousing (2003)

Relational database systems provide an infrastructure for supporting online transaction processing (q.v.). However, most relational stores are not optimized with regard to supporting summarization, aggregation, and ad hoc querying over large relational databases. As organizations began to rely increasingly on data to influence business decisions, the perceived roles of a database system within organizations has begun to evolve from being primarily data capture and reliable storage, to also enable decision support. Decision support imposes new requirements which include data exploration, summarization, analysis, and advanced reporting. The systems that use a database system as a central component in supporting decision support are referred to as data warehouses. The evolution of databases from being mainly transactional to being a repository of information to be analyzed by decision support tools is illustrated in Fig. 1. Some of the decision support tools are either natively supported in databases or are external client/middleware applications.
Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann–Pick C1‐deficient neurons (2002)

Niemann-Pick type-C (NPC) disease is characterized by a progressive loss of neurons and an accumulation of unesterified cholesterol within the endocytic pathway. Unlike other tissues, however, NPC1-deficient brains do not accumulate cholesterol but whether or not NPC1-deficient neurons accumulate cholesterol is not clear. Therefore, as most studies on cholesterol homeostasis in NPC1-deficient cells have been performed in fibroblasts we have investigated cholesterol homeostasis in cultured murine sympathetic neurons lacking functional NPC1. These neurons did not display obvious abnormalities in growth or morphology and appeared to respond normally to nerve growth factor. Filipin staining revealed numerous cholesterol-filled endosomes/lysosomes in NPC1-deficient neurons and the mass of cholesterol in cell bodies was greater than in wild-type neurons. Surprisingly, however, the cholesterol content of NPC1-deficient and wild-type neurons as a whole was the same. This apparent paradox was resolved when the cholesterol content of NPC1-deficient distal axons was found to be less than of wild-type axons. Cholesterol sequestration in cell bodies did not depend on exogenously supplied cholesterol since the cholesterol accumulated before birth and did not disperse when neurons were cultured without exogenous cholesterol. The altered cholesterol distribution between cell bodies and axons suggests that transport of cholesterol, particularly that synthesized endogenously, from cell bodies to distal axons is impaired in NPC1-deficient neurons.
HF multiresonant electronic ballast for fluorescent lamps with constant filament preheat voltage (2003)

A novel HF multiresonant ballast for fluorescent lamps is analyzed, simulated, and tested experimentally. The ballast includes two major resonant networks. The lamp is driven by a parallel resonance arrangement that acts as a current source. During warm up the filaments are driven by a secondary winding of a series resonant inductor. The series resonance branch, which is active during warm up, feeds the filament and shorts out the voltage across the lamp. Simulation and experimental results suggest that the inherent features of the proposed ballast topology will prolong lamp life.
Betatron radiation from electron beams in plasma focusing channels (2001)

Spontaneous radiation emitted from an electron undergoing betatron motion is a plasma focusing channel is analyzed and applications to plasma wakefield accelerator experiments and to the ion channel laser (ICL) are discussed. Important similarities and differences between a free electron laser (FEL) and in an ICL are delineated. It is shown that the frequency of spontaneous radiation is a strong function of the betatron strength parameter aβ, which plays a similar role to that of the wiggler strength parameter in a conventional FEL. For aβ≳1, radiation is emitted in numerous harmonics. Furthermore, aβ is proportional to the amplitude of the betatron orbit, which varies for every electron in the beam. This places serious limits on the possibility of realizing an ICL.
THE ELECTRONIC STRUCTURES AND REACTIVITIES OF Mn(CO)<sub>5</sub>X COMPLEXES (1963)

The bonding in Mn(CO) 5 X complexes is described in terms of molecular orbitals. The axial CO group is assumed to be bonded much more strongly to Mn than the other four CO groups. The molecular orbital energy level scheme thus derived successfully accounts for the principal features of the electronic spectra of Mn(CO) 5 X complexes in different solvents. The first charge transfer band is assigned as an n(Mn) → π*(CO) type transition. This n → π* assignment is supported by the fact that the maximum of the band for Mn(CO) 5 Br is shifted to higher energies on increasing the polarity of the solvents employed.Kinetic studies of Mn(CO) 5 X- 14 CO exchange reveal that the axial CO is more inert than the other four CO groups; also, the rates of 14 CO exchange of the four equivalent CO groups in Mn(CO) 5 X complexes depend strikingly on the nature of the X − ligand. A consistent interpretation of the above results and the observed kinetics of some typical substitution reactions of Mn(CO) 5 X complexes is presented in terms of the derived electronic structural description.
Olivier Coquelin, L’Irlande en révolutions, entre nationalismes et conservatismes : une histoire politique et sociale, 18e-20e siècles (2019)

Dans cet ouvrage, tiré d’une thèse enrichie de multiples travaux entrepris depuis, Olivier Coquelin propose de faire l’étude de ce qui semble être une singularité irlandaise. La décennie révolutionnaire qui s’achève en 1923 a vu émerger les clivages qui dominent encore la vie politique de l’île. Cependant ceux-ci ne se sont pas matérialisés par des différences d’approches sociales ou économiques, cet épisode débouchant sur le renforcement d’une idéologie nationale conservatrice transpartisane...
Comparison of Mechanical Performance in Four Types of External Fixators (1983)

The Hoffmann-Vidal triangular apparatus for fracture fixation of the femur, the Volkov-Oganesian device with Steinmann pins in tension, the Kronner device with a plastic elliptic frame, and the Roger-Anderson apparatus (both standard and compression-distraction designs) were studied based on loading and analytic methods established previously. The results were compared with those for the standard Hoffmann-Vidal quadrilateral configuration. The Kronner device, with five connecting bars, was the stiffest under most loading modes, closely followed by the Hoffmann-Vidal quadrilateral apparatus. The standard Roger-Anderson device demonstrated average rigidity; its new design with compression-distraction capability was relatively weak. All devices showed an apparent weakness in antero-posterior bending. The Volkov-Oganesian design demonstrated low overall stiffness but was the most effective apparatus in resisting anteroposterior bending. External fixators provide effective compression at the fracture site, and the amount of compression is proportional to the stiffness of the apparatus.
‘Subtle strangles’ – the more elusive signs of the disease (2019)

Fleur Whitlock BVetMed (Hons) MRCVS, Richard Newton BVSc MSc PhD FRCVS, Andrew Waller BSc PhD, of the Animal Health Trust discuss the less obvious presentations
Quantitative metrics that describe river deltas and their channel networks (2011)

[1] Densely populated river deltas are losing land at an alarming rate and to successfully restore these environments we must understand the details of their morphology. Toward this end we present a set of five metrics that describe delta morphology: (1) the fractal dimension, (2) the distribution of island sizes, (3) the nearest-edge distance, (4) a synthetic distribution of sediment fluxes at the shoreline, and (5) the nourishment area. The nearest-edge distance is the shortest distance to channelized or unchannelized water from a given location on the delta and is analogous to the inverse of drainage density in tributary networks. The nourishment area is the downstream delta area supplied by the sediment coming through a given channel cross section and is analogous to catchment area in tributary networks. As a first step, we apply these metrics to four relatively simple, fluvially dominated delta networks. For all these deltas, the average nearest-edge distances are remarkably constant moving down delta suggesting that the network organizes itself to maintain a consistent distance to the nearest channel. Nourishment area distributions can be predicted from a river mouth bar model of delta growth, and also scale with the width of the channel and with the length of the longest channel, analogous to Hack's law for drainage basins. The four delta channel networks are fractal, but power laws and scale invariance appear to be less pervasive than in tributary networks. Thus, deltas may occupy an advantageous middle ground between complete similarity and complete dissimilarity, where morphologic differences indicate different behavior.
Size and complex index of nanocenters: optical measurements (2004)

Non destructive detection, localization and characterization of nanocenters today remains a challenge for investigation of laser-induced damage in optical materials. In this study we propose an attempt to reach this aim via optical techniques, and extract size and complex index of nanocenters. The procedure is described and results are given for <i>SiO</i><sub>2</sub> thin film samples. All conclusions are discussed in regard to assumptions.
Abstract 5008: Epidermal growth factor downregulates expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells (2011)

Abstract Background: Neutrophil gelatinase-associated lipocalin (NGAL), a member of the lipocalin family, is a secreted protein that is upregulated in multiple cancer types. Our group previously reported that NGAL overexpression significantly blocked invasion and angiogenesis in pancreatic ductal adenocarcinoma (PDAC). We and others have also demonstrated loss NGAL expression in advanced stages of PDAC. However, little is known about mechanisms that regulate NGAL expression in PDAC. As EGF-EGFR axis is significantly upregulated in PDAC, we examined EGF-mediated NGAL regulation in these cells. Methods: NGAL-positive AsPC-1 and BxPC-3 cells were used as model system. Quantitative RT-PCR, western blot analysis, and immunofluorescence studies were used to investigate EGF-mediated effects on NGAL expression. E-cadherin expression was manipulated using lentiviral overexpression or shRNA constructs. NGAL promoter activity was assessed by luciferase-reporter assay and electrophoretic mobility shift assay (EMSA). Results: NGAL expression was positively associated with tumor differentiation and was significantly downregulated after EGF treatment along with a concomitant reduction of E-cadherin expression in PDAC cells. E-cadherin downregulation was partly through the EGF receptor (EGFR)-dependent MEK1/2-ERK1/2 signaling pathway, which was demonstrated using pharmacologic inhibitors of EGFR (AG1478) and MEK1/2 (U0126 and PD98059). In addition, E-cadherin downregulation reduced NGAL expression in PDAC cells, whereas overexpression of E-cadherin led to increased NGAL expression and partly rescued inhibition of NGAL expression by EGF. Furthermore, EGF in part through E-cadherin reduced NGAL promoter activity by blocking NF-κB activation. Conclusion: We demonstrated for the first time that EGF potently blocked NGAL expression in PDAC cells. This effect is partly mediated through activation of the EGFR-MEK1/2-ERK1/2 signaling pathway, which in turn downregulated E-cadherin with a subsequent reduction in NF-κB activation. Our findings illustrate a novel mechanism by which EGF regulates NGAL expression in PDAC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5008. doi:10.1158/1538-7445.AM2011-5008
Histologic Findings of the Heart and the Conduction System in the First Patient Who Underwent Catheter Ablation (1992)

This is a detailed pathological examination of the heart including the conduction system (CS) from a 64-year-old male who had catheter ablation of the atrioventricular (AV) junction for intractable atrial fibrillation. This is the world's first human who had this procedure, and who survived 3 years and 8 months, and later died of congestive heart failure. Pathologically, the heart was hypertrophied and enlarged. Histologically, there were chronic inflammatory cells, marked fatty metamorphosis with fibrosis of the atria, the approaches to the AV node, and the AV node, with almost isolation of the node from the atria, and considerable fibrosis of the bundle and bundle branches. In addition, there was fibrosis of the summit of the ventricular septum with chronic inflammatory cells. These represent the sequelae of the ablation procedures. It is not known how much of the pathological findings contributed to the cardiac hypertrophy and impairment of cardiac function.
InCoB2010 - 9th International Conference on Bioinformatics at Tokyo, Japan, September 26-28, 2010 (2010)

The International Conference on Bioinformatics (InCoB), the annual conference of the Asia-Pacific Bioinformatics Network (APBioNet), is hosted in one of countries of the Asia-Pacific region. The 2010 conference was awarded to Japan and has attracted more than one hundred high-quality research paper submissions. Thorough peer reviewing resulted in 47 (43.5%) accepted papers out of 108 submissions. Submissions from Japan, R.O. Korea, P.R. China, Australia, Singapore and U.S.A totaled 43.8% and contributed to 57.4% of accepted papers. Manuscripts originating from Taiwan and India added up to 42.8% of submissions and 28.3% of acceptances. The fifteen articles published in this BMC Bioinformatics supplement cover disease informatics, structural bioinformatics and drug design, biological databases and software tools, signaling pathways, gene regulatory and biochemical networks, evolution and sequence analysis.
Dielectric spectroscopic determination of temperature behavior of electroclinic parameters in the liquid crystal W317 (1995)

We report measurements of the temperature behavior of the electroclinic coupling coefficient c(T) and the inverse tilt susceptibility A(T), the principal phenomenological parameters determining the magnitude of the electroclinic effect in the chiral smectic A phase of the liquid crystal W317, a material which exhibits an anomalously large electroclinic effect with unusual thermal behavior. We find that c(T) decreases by ∼30% in response to a 40 °C increase in temperature. A(T) exhibits a mean field behavior at high temperature, increasing by a factor of 3 as temperature is increased over the range 40 °C&lt;T&lt;65 °C. However, below ∼40 °C, A(T) becomes nearly independent of temperature over a ∼10 °C range around room temperature. This A(T) behavior has not been previously found in electroclinic materials.
Tetrahedral Onsager Crosses for Solubility Improvement and Crystallization Bypass (2001)

Pure organic molecules exhibiting a suitable concave rigid shape are expected to give porous glasses in the solid state. Such a feature opens new opportunities to avoid crystallization and to improve molecular solubility in relation to the high internal energy of these solid phases. To quantitatively explore the latter strategy, a series of rigid tetrahedral conjugated molecules nC and the corresponding models nR have been synthesized. Related to the present purpose, several properties have been investigated using UV absorption, steady-state fluorescence emission, differential scanning calorimetry, (1)H NMR translational self-diffusion, magic angle spinning (13)C NMR, and multiple-beam interferometry experiments. The present tetrahedral crosses are up to 8 orders of magnitude more soluble than the corresponding model compounds after normalization to the same molecular length. In addition, they give concentrated monomeric solutions that can be used to cover surfaces with homogeneous films whose thickness goes down to the nanometer range. Such attractive features make cross-like molecular architectures promising for many applications.
Temperature Dependence of some Cation Exchange Equilibria in the Range 0 to 200°( (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTemperature Dependence of some Cation Exchange Equilibria in the Range 0 to 200°(Kurt A. Kraus and Richard J. RaridonCite this: J. Phys. Chem. 1959, 63, 11, 1901–1907Publication Date (Print):November 1, 1959Publication History Published online1 May 2002Published inissue 1 November 1959https://pubs.acs.org/doi/10.1021/j150581a026https://doi.org/10.1021/j150581a026research-articleACS PublicationsRequest reuse permissionsArticle Views209Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Unusual Contaminant in JP-4 Fuel Delivered to Fort Campbell, Fort Knox, and Tennessee Army National Guard. (1985)

Many common types of debris were encountered during the course of a recent investigation to identify an unusual contaminant present in jet fuel (JP-4) at three Army locations. Most of the other debris were materials commonly found in fuel samples, e.g. metal flakes, rust, fibers, dirt, etc. Various analytical techniques used in this evaluation indicated that the unusual flake-like organic debris was probably a manmade (synthetic) organic component and not a fuel product. It had a high melting point (200 C) and was insoluble in most common solvents. The physical appearance of the flakes (thin and flat while floating in the fluid) indicated that the material was originally formed or deposited in a thin layer prior to its introduction into the fuel. The most likely source of a material with these characteristics was an unpigmented paint or protective coating from one of the epoxy or similar resin families. Such a material could be introduced into the fuel by debonding or delamination of the contaminant from any handling, storage, or transportation equipment that contains such a coating. The elements, chemical bonds, and functional groups detected by the various analytical tests were consistent with this conclusion. The use of a light box for enhanced visual (Clean and Bright) evaluation is presented in this report. Also discussed is an approach for isolating similar debris (from fuel) to provide for scanning electron microscopic, Auger, and Electron Spectroscopy for chemical analysis (ESCA) evaluation.
Abstract #5551: The impact of expression of BER proteins on therapeutic effect of combining temozolomide with methoxyamine in melanoma cells (2009)

Base excision repair (BER) is a highly coordinated cellular biochemical system essential to cell survival. Variability of expression of BER proteins may affect the dynamics of the repair pathway or change the repair rate that determines the cellular sensitivity to the cytotoxicity exerted by alkylating agents. In the present study, we examined the relationship between the expression of BER proteins and therapeutic effect of temozolomide (TMZ) and the combination of TMZ and methoxyamine (MX), a BER inhibitor, in melanoma cells in vitro and in xenografts. The levels of BER proteins (including MPG, UDG, APE, and Pol \#946;) were measured by western blotting assay in 4 cell lines, SkmCI-1, WM164, A375, and WM9. Results revealed that BER proteins were coordinately and differentially expressed in these melanoma cell lines, higher in A375 and much lower in WM164 cells. There were no significant differences in MGMT and MLH1-MSH2, two well known TMZ resistant factors in these two cell lines. To determine the role of BER proteins in TMZ cytotoxicity, clonogenic survival studies were performed in A375 and WM164 cells. The sensitivity to TMZ alone in these two cell lines was assessed by IC90 value produced by survival assay, showing 490 µM in A375 and 570 µM in WM164 cells. When cells were treated with the combination of TMZ and MX, MX efficiently potentiated TMZ cytotoxicity by 3 folds in A375 but failed to enhance the killing effect of TMZ in WM164 cells. Similar results were observed in xenografts. In xenograft study, MX enhanced TMZ antitumor effect, resulting in tumor growth delays of 13 days in mice receiving the combination of TMZ (80 mg/kg) and MX (2 mg/kg) i.p daily for five days in comparison to 6 days in mice treated with TMZ alone. No enhancement of TMZ-antitumor activity by MX was observed in mice carrying WM164 melanoma xenografts. The results suggest that the failure of TMZ-potentiation by MX in WM164 cells was related to the low activity of BER proteins, particularly low levels of MPG DNA glycosylase. Deficiency of the BER proteins would decrease the formation of AP sites, the targets for MX action. These results indicate that BER proteins may be differentially expressed in tumor cells, which particularly impact the therapeutic effect of combining TMZ with MX. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5551.