gebhart/patrepeval huggingface dataset:
Repeated Measures Semiparametric Regression Using Targeted Maximum Likelihood Methodology with Application to Transcription Factor Activity Discovery (2011)

In longitudinal and repeated measures data analysis, often the goal is to determine the effect of a treatment or aspect on a particular outcome (e.g., disease progression). We consider a semiparametric repeated measures regression model, where the parametric component models effect of the variable of interest and any modification by other covariates. The expectation of this parametric component over the other covariates is a measure of variable importance. Here, we present a targeted maximum likelihood estimator of the finite dimensional regression parameter, which is easily estimated using standard software for generalized estimating equations. The targeted maximum likelihood method provides double robust and locally efficient estimates of the variable importance parameters and inference based on the influence curve. We demonstrate these properties through simulation under correct and incorrect model specification, and apply our method in practice to estimating the activity of transcription factor (TF) over cell cycle in yeast. We specifically target the importance of SWI4, SWI6, MBP1, MCM1, ACE2, FKH2, NDD1, and SWI5. The semiparametric model allows us to determine the importance of a TF at specific time points by specifying time indicators as potential effect modifiers of the TF. Our results are promising, showing significant importance trends during the expected time periods. This methodology can also be used as a variable importance analysis tool to assess the effect of a large number of variables such as gene expressions or single nucleotide polymorphisms.
Relighting Acquired Models of Outdoor Scenes (2005)

In this paper we introduce a relighting algorithm for diffuse outdoor scenes that enables us to create geometrically correct and illumination consistent models from a series of range scans and a set of overlapping photographs that have been taken under different illumination conditions. To perform the relighting we compute a set of mappings from the overlap region of two images. We call these mappings irradiance ratio maps (IRMs). Our algorithm handles cast shadows, being able to relight shadowed regions into non-shadowed regions and vice-versa. We solve these cases by computing four different IRMs, to handle all four combinations of shadowed vs. non-shadowed surfaces. To relight the non-overlapping region of an image, we look into the appropriate IRM which we index on surface normal, and apply its value to the corresponding pixels. The result is an illumination consistent set of images.
Scattering of an electromagnetic wave from a slightly random dielectric surface: Yoneda peak and Brewster angle in incoherent scattering (1997)

Abstract The scattering of an electromagnetic wave from a two-dimensional, slightly rough dielectric surface is studied based on the stochastic functional approach. It is shown that in the case of TM(p)-polarized incidence there exists a zero in the incoherent scattering at the angle we call the ‘Brewster scattering angle’, which depends on the incident angle in contrast to the Brewster angle of coherent reflection which is independent of the incident angle, that a ‘quasi-anomalous scattering’ can generally occur in the optically denser medium at the critical angle of total reflection in both TE(s)- and TM(p)-polarized incidence, regardless of which side of the random surface is illuminated, and that the Yoneda peak in the x-ray scattering can be interpreted as a special case of the quasi-anomalous scattering which becomes sharper when the relative refractive index becomes closer to unity as in the x-ray region. Cross-polarized scattering and enhanced backscattering due to the second-order effect are also calculated.
Cytotoxic Monotetrahydrofuran Acetogenins from <i>Disepalum </i><i>plagioneurum</i> (2006)

The known plagionicin A (1) and eight new monotetrahydrofuran acetogenins, plagionicins B-D (2-4) and plagioneurins A-E (5-9), were isolated from the leaves of Disepalum plagioneurum by bioassay-guided purification. The structures of the new compounds were elucidated by spectroscopic methods. The new monotetrahydrofuran (mono-THF) acetogenins exhibited significant in vitro cytotoxicity against the KB cancer cell line, with IC(50) values in the nanomolar range.
Advanced modeling techniques for computer graphics (1996)

article Free AccessAdvanced modeling techniques for computer graphics Author: David S. Ebert Computer Science and Electrical Engineering Department, University of Maryland Computer Science and Electrical Engineering Department, University of MarylandView Profile Authors Info & Claims ACM Computing SurveysVolume 28Issue 1March 1996 pp 153–156https://doi.org/10.1145/234313.234378Published:01 March 1996Publication History 8citation1,339DownloadsMetricsTotal Citations8Total Downloads1,339Last 12 Months89Last 6 weeks32 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Relationship between dispersion metric and properties of PMMA/SWNT nanocomposites * (2007)

Particle spatial dispersion is a crucial characteristic of polymer composite materials and this property is recognized as especially important in nanocomposite materials due to the general tendency of nanoparticles to aggregate under processing conditions. We introduce dispersion metrics along with a specified dispersion scale over which material homogeneity is measured and consider how the dispersion metrics correlate quantitatively with the variation of basic nanocomposite properties. We then address the general problem of quantifying nanoparticle spatial dispersion in model nanocomposites of single wall carbon nanotubes (SWNT) dispersed in poly(methyl methacrylate) (PMMA) at a fixed SWNT concentration of 0.5 % using a 'coagulation' fabrication method. Two methods are utilized to measure dispersion, UV-Vis spectroscopy and optical confocal microscopy. Quantitative spatial dispersion levels were obtained through image analysis to obtain a 'relative dispersion index' (RDI) representing the uniformity of the dispersion of SWNTs in the samples and through absorbance. We find that the storage modulus, electrical conductivity, and flammability containing the same amount of SWNTs, the relationships between the quantified dispersion levels and physical properties show about four orders of magnitude variation in storage modulus, almost eight orders of magnitude variation in electric conductivity, and about 70 % reduction in peak mass loss rate at the highest dispersion level used in this study. The observation of such a profound effect of SWNT dispersion indicates the need for objective dispersion metrics for correlating and understanding how the properties of nanocomposites are determined by the concentration, shape and size of the nanotubes.
ChemInform Abstract: DIORGANOSTYRYLSTANNYLDIORGANOPHOSPHINES AND THEIR TRICARBONYLNICKEL COMPLEXES (1980)

Abstract Chlorstannane (I) reagieren mit Silylphosphinen (II) zu Stannylphosphinen (III).
Integration of InAlAs/InGaAs/InP enhancement- and depletion-mode high electron mobility transistors for high-speed circuit applications (1998)

A process for the monolithic integration of enhancement- and depletion-mode high electron mobility transistors (E/D-HEMTs) on InAlAs/InGaAs/InP is reported. The E-HEMTs with a 1.0-/spl mu/m gate length exhibit a threshold voltage of +255 mV and a maximum dc extrinsic transconductance of 503 mS/mm at room temperature, while a threshold voltage of -317 mV and a transconductance of 390 mS/mm are measured for the D-HEMTs of the same gate length. The devices show excellent RF performance, with a unity current-gain cutoff frequency (f/sub t/) of 35 GHz and a maximum frequency of oscillation (f/sub max/) of 95 GHz for both the E- and D-HEMT's. To the best of the authors' knowledge, this is the first demonstration of an E/D-HEMT technology on lattice-matched InP that is suitable for circuit integration.
Flexible Shear Sensor Based on Embedded Optoelectronic Components (2011)

Tactile shear stresses play an important role in the medical field and robotics. To monitor these stresses in situ, there is a need for unobtrusive flexible sensors that can be wrapped around curved surfaces or moving body parts. The presented sensor is based on changing coupling of optical power between a vertical-cavity surface-emitting laser (VCSEL) and a photodiode facing each other and separated by a deformable transducer layer. The required optoelectronic components were embedded in a polymer foil of only 40 μm thick, yielding a very thin and flexible total sensor stack of 250 μm thick. In the linear part of the range (between 2 and 5.5 N), the sensitivity of the prototype was -350 μA/N; the maximum measurable force was 5.5 N. However, by selecting the appropriate deformable sensor transducer material, the sensitivity and range can be tuned for a specific application.
Pipeline synthesis of SRSL circuits (2005)

In this paper, a methodology to synthesize SRSL pipelines has been presented. The synthesis of SRSL pipelines is formulated as an IP problem subject to area and timing constraints for which a heuristic procedure is proposed and applied on six circuits. Experiments reveal that SRSL pipelining is highly suitable for coarse-grain datapaths where these pipelines can yield throughput beyond the 1 GHz mark for large and deep circuits.
Studies on the Syntheses of Heterocyclic Compounds. LIII. The Formation of Vanillide and Polyvanillide. (1959)

Treatment of 4-benzylvanillic acid with thionyl chloride, without use of a catalyst, afforded a polymer and sublimation of this polymer in vacuo gave a dimer of vanillide. According to the molecular weight determination and infrared absorption spectra, this polymer was recognized to be a tetramer and to have an ester, so that the polymer must have been formed from four molecules of the acid by removal of benzyl chloride during the reaction. Therefore, it is thought to be a polyester. The sublimate on the other hand was found to be a dimer formed from the tetramer by thermal decomposition.
Basicities and H--D exchange of pyrazine N-oxides (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBasicities and H--D exchange of pyrazine N-oxidesWilliam W. Paudler and Sharon A. HumphreyCite this: J. Org. Chem. 1970, 35, 10, 3467–3470Publication Date (Print):October 1, 1970Publication History Published online1 May 2002Published inissue 1 October 1970https://pubs.acs.org/doi/10.1021/jo00835a063https://doi.org/10.1021/jo00835a063research-articleACS PublicationsRequest reuse permissionsArticle Views171Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Heat and water transfer in a rotating drum containing solid substrate particles (2003)

In previous work we reported on the simulation of mixing behavior of a slowly rotating drum for solid-state fermentation (SSF) using a discrete particle model. In this investigation the discrete particle model is extended with heat and moisture transfer. Heat transfer is implemented in the model via interparticle contacts and the interparticle heat transfer coefficient is determined experimentally. The model is shown to accurately predict heat transfer and resulting temperature gradients in a mixed wheat grain bed. In addition to heat transfer, the addition and subsequent distribution of water in the substrate bed is also studied. The water is added to the bed via spray nozzles to overcome desiccation of the bed during evaporative cooling. The development of moisture profiles in the bed during spraying and mixing are studied experimentally with a water-soluble fluorescent tracer. Two processes that affect the water distribution are considered in the model: the intraparticle absorption process, and the interparticle transfer of free water. It is found that optimum distribution can be achieved when the free water present at the surface of the grains is quickly distributed in the bed, for example, by fast mixing. Alternatively, a short spraying period, followed by a period of mixing without water addition, can be applied. The discrete particle model developed is used successfully to examine the influence of process operation on the moisture distribution (e.g., fill level and rotation rate). It is concluded that the extended discrete particle model can be used as a powerful predictive tool to derive operating strategies and criteria for design and scale-up for mixed SSF and other processes with granular media.
Trabeculectomy in Pseudophakie Patients: Postoperative 5-Fluorouracil Versus Intraoperative Mitomycin C Antiproliferative Therapy (1995)

Trabeculectomy outcome in pseudophakic glaucoma patients treated with mitomycin C (MMC) or 5-fluorouracil (5-FU) was analyzed retrospectively in 46 cases (46 eyes). Thirty patients received intraoperative MMC; 16, 5-FU. There were no significant differences between the two groups in terms of preoperative data (demographics, number of previous filtering procedures, visual acuity, and intraocular pressure [IOP]). After a mean follow up of 13.4 +/- 8.1 and 11.5 +/- 5.8 months for the 5-FU and MMC groups, respectively, 12 5-FU eyes (75%) and 21 MMC eyes (70%) were deemed at least qualified successes (IOP < or = 21 mm Hg with or without antiglaucoma medications). Six (37.5%) of the 5-FU eyes and 13 (43.3%) of the MMC eyes were complete successes (IOP < or = 21 mm Hg without antiglaucoma medications). There were no significant differences between the two groups in terms of duration of follow up, number of qualified successes, and number of complete successes (P = .35, .9, and .7, respectively). Nor were there any significant differences in the mean final IOPs and visual acuities. Excluding transient corneal effects associated with 5-FU therapy, there were no significant differences in the frequency of postoperative complications. These results suggest that 5-FU and MMC antiproliferative therapy are associated with similar short-term success rates and postoperative complications.
High Accuracy Flow Rate Measurements: An Entire Multiphase Solution at the Well Site (2007)

Representative reservoir fluid sampling and characterization has become increasingly important over the years. With exploration, appraisal and development activities moving into marginal fields and more challenging environments, accurate fluid characterization becomes more critical. This can be said for the formation tester, DST and multiphase sampling and fluid characterization environments with the most challenging area in recent years arguably being the multiphase environment. Multiphase flow meters have been accepted for several years now by the industry. Their use in permanent or well testing applications has been growing rapidly. In many cases, multiphase flow meters have replaced the separator for flow rate evaluation, but some fundamental needs from the client were not addressed properly, such as the ability to collect representative samples for phase-behavior characterization. Moreover, metering accuracies has been questionable in many cases (at very high GVF or in wet gas conditions, high pressure or /and high temperature).This paper focus on the Multiphase Active Sampling Device Service (MASS), a fluid sampling and analysis service that can be provided with the Vx multiphase metering technology with the objective of collecting representative samples, isolating and analyzing each fluid phase, and providing data from the analysis to input to the Vx acquisition software data to obtain more accurate flow rates. The collection of phase representative samples also opens the opportunity for a full recombination PVT study to be performed using the improved recombination ratio at line conditions from the multiphase flow meter. This dedicated multiphase fluid sampling and analysis system, combined with Vx technology provides flow rate better and fluid property than to a conventional test separator system.
Electrospray mass spectrometric determination of polycyclic aromatic hydrocarbons by detecting the π–π complexes with tropylium cation (1999)

A method is presented for the determination of polycyclic aromatic hydrocarbons (PAHs) by detecting the PAH–tropylium (π donor–π acceptor) complexes using liquid chromatography-electrospray ionization-mass spectrometry. The complexes were formed by mixing with the tropylium cation after the separation of PAHs through reversed phase liquid chromatography. The detection limits, defined as three times the noise, in the selected-ion monitoring mode were 25–165 ng of the injected PAHs.
Using Knowledge to Facilitate Pinpointing of Factoid Answers (2002)

In order to answer factoid questions, the Webclopedia QA system employs a range of knowledge resources. These include a QA Typology with answer patterns, WordNet, information about typical numerical answer ranges, and semantic relations identified by a robust parser, to filter out likely-looking but wrong candidate answers. This paper describes the knowledge resources and their impact on system performance.
How Reliable Is 13C-Acetate Breath Testing for Measuring Accelerated Gastric Emptying of Different Isocaloric Test Meals in Functional Dyspepsia and Health? A Comparison with MRI (2005)

Aim: To compare continuous 13C-breath test (BT) and a Magnetic Resonance Imaging (MRI) or gastric barostat method for measurement of gastric emptying and accommodation in patients with functional dyspepsia (FD) and healthy controls (HC). We hypothesized that impaired accommodation can be indirectly measured by the accelerated emptying rate of a high volume nutrient liquid meal, as assessed by BT, due to a higher intragastric pressure. Methods: 8 healthy controls and 8 dyspeptic patients underwent continuous 13C-breath testing with simultaneous MRI study on 2 occasions after ingestion of a 200ml, 300 kcal liquid meal or an isocaloric 800ml meal, both labeled with 100mg of 13C sodium acetate and 0.5 mM Gd-DOTA. On a third day, all subjects received a 200ml meal during a gastric barostat study. Breath samples were automatically collected for 3.5 hours via a nasal canula and analyzed using real-time molecular correlation spectrometry. MR images of the gastric region were acquired in seated position in a 0.5T open configuration MR system before and at regular intervals until 2 hours postprandially. Gastric emptying curves were fitted to a non-linear model. Half-emptying times (T1/2 [min]) and MRI emptying rates were calculated. Results: T1/2 (mean±SD) were significantly lower for the 800ml meal as assessed by MRI (p<0.004 vs. 200ml meal), but similar in HC and FD (T1/2 MRI 200ml: HC 113±28, FD 127±31; T1/2 MRI 800ml: HC 72±16; FD 78±24). For BT T1/2 were similar between meals and groups (T1/2 BT 200ml: HC 111±11, FD 116±19; T1/2 BT 800ml: HC114±14, FD: 113±17). Mean MRI gastric emptying rate for HC and FD 15–90 minutes postprandially was 1.3±0.7 and 1.0±0.8ml/min for the 200ml meal and 6.3±1.8 and 5.6±1.6ml/min for the 800ml meal (p<0.001 between meals). Barostat measurements showed a mean postprandial volume increase of 344±91ml for HC and 316±154ml for FD (ns). Only one patient with FD had impaired accommodation by barostat, but showed not enhanced gastric emptying by MRI or BT. Conclusions: BT failed to detect accelerated gastric emptying of high volume liquid meals as assessed by MRI. This indicates that 13CO2 exhalation depends on factors other than velocity of gastric emptying, such as meal composition, substrate dose and concentration.
ChemInform Abstract: Syntheses of Morindaparvin A and Its Derivatives. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Glucocorticoids upregulate taurocholate transport by ileal brush-border membrane (1997)

The regulation of the enterohepatic circulation of bile acids has not been fully elucidated. Substrate availability has been shown to have a regulatory role on the ileal uptake of taurocholate (TC) by a positive feedback mechanism. Other mechanisms are likely to be involved in regulating ileal bile acid uptake. The present study was designed to test the hypothesis that the ileal bile acid transporter (iBAT) is glucocorticoid sensitive and that changes in expression are mediated by changes in iBAT synthesis. Adult Sprague-Dawley rats (300-400 g) received intraperitoneal injections with either corticosterone (5 mg/ 100 g body weight) or an equivalent vehicle (control) daily for 3 days. On day 4, ileal brush-border membrane vesicles (BBMV) and hepatic basolateral membrane vesicles (BLMV) were prepared, and TC transport was performed using the rapid filtration technique. Initial velocity was measured at selected time points, and kinetics were calculated over a range of TC concentrations. Ileal RNA was isolated, and Northern analysis of steady-state iBAT mRNA levels was determined. Western blot analysis was performed to quantitate the level of the 48-kDa iBAT protein. The initial velocity of Na(+)-dependent TC uptake at 30 s by ileal BBMV was higher in treated animals (264.3 +/- 64.6 pmol/mg protein) compared with control animals (148.3 +/- 41.1 pmol/mg protein; P = 0.07). The maximal velocity of uptake (Vmax) was significantly higher in treated vs. control animals (1,091 +/- 62.7 vs. 689.1 +/- 55.0 pmol.min-1.mg protein-1, respectively; P = 0.002), whereas there was no significant difference in the Michaelis constant (Km) between the control and treated animals (43.3 +/- 7.2 vs. 35.3 +/- 8.7 microM, respectively; P = not significant). Steady-state iBAT mRNA levels were increased twofold in the treated vs. control groups. Western blot analysis showed that the abundance of the 48-kDa iBAT protein was eightfold higher in the treated animals compared with control. Kinetic analysis of hepatic Na(+)-dependent TC uptake revealed nearly identical Vmax and Km between the study and control animals. Therefore, we conclude that TC transport by ileal BBMV is upregulated by administration of glucocorticoids. The increase in BBMV transport Vmax corresponds to an increase in both iBAT transcript and protein.