gebhart/patrepeval huggingface dataset:
Use of vascular endothelial cell growth factor gene transfer to enhance implantable sensor function <i>in vivo</i> (2003)

In the current study, we developed and validated a simple, rapid and safe in vivo model to test gene transfer and sensor function in vivo. Using the model, we tested the specific hypothesis that in vivo gene transfer of angiogenic factors at sites of biosensor implantation would induce neovascularization surrounding the sensor and thereby enhance biosensor function in vivo. As the in vivo site for testing of our gene transfer cell and biosensor function systems, the developing chorioallantoic membrane (CAM) of the embryo was utilized. Vascular endothelial cell growth factor (VEGF) was used as a prototype for angiogenic factor gene transfer. A helper-independent retroviral vector derived from Rous sarcoma virus (RSV), designated RCAS, was used for gene transfer of the murine VEGF (mVEGF) gene (mVEGF:RCAS) into the DF-1 chicken cell line (designated mVEGF:DF-1). Initially, the ability of VEGF:DF-1 cells to produce VEGF and RCAS viral vectors containing the mVEGF gene (mVEGF:RCAS) was validated in vitro and in vivo, as was the ability of the mVEGF:DF-1 cells to induce neovascularization in the ex ova CAM model. Using the system, we determined the ability of mVEGF:DF-1 cells to enhance acetaminophen sensor function in vivo, by inducing neovascularization at sites of sensor implantation in the ex ova CAM model. For these studies, acetaminophen sensors were placed on 8-day-old ex ova CAMs, followed by addition of media or cells (mVEGF:DF-1 cells or GFP:DF-1 cells) at the sites of biosensor implantation on the CAM. At 4 to 10 days after sensor placement, the biosensor function was determined by measuring sensor response to an intravenous injection of acetaminophen. Sensors implanted on CAMs with buffer or control cells (GFP:DF-1 cells) displayed no induced neovascularization around the sensor and had minimal/baseline sensor responses to intravenous acetaminophen injection (media, 133.33 +/- 27.64 nA; GFP:DF-1, 187.50 +/- 55.43 nA). Alternatively, the sensors implanted with mVEGF:DF-1 cells displayed massive neovascularization and equally massive sensor response to intravenous injection of acetaminophen (VEGF:DF-1, 1387.50 +/- 276.42 nA). These data clearly demonstrate that enhancing vessel density (i.e., neovascularization) around an implanted sensor dramatically enhances sensor function in vivo.
Effect of Neutron Irradiation on the Activity of Silica-Alumina Catalyst for the Double Bond Isomerization of Butene-1 (1959)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation P. J. Lucchesi, D. L. Baeder, J. P. Longwell, M. C. Schroeder; Effect of Neutron Irradiation on the Activity of Silica‐Alumina Catalyst for the Double Bond Isomerization of Butene‐1. J. Chem. Phys. 1 August 1959; 31 (2): 558–559. https://doi.org/10.1063/1.1730412 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioThe Journal of Chemical Physics Search Advanced Search |Citation Search
Bone loss is detected more frequently in patients with ankylosing spondylitis with syndesmophytes. (2005)

The majority of patients with AS had reduced bone density. The method of bone density measurement is critical and should be different depending on disease duration. The finding that more patients with syndesmophytes had reduced bone density than those without suggests that bone growth and bone loss occur in parallel, and the role of inflammation in this process warrants further investigation.
Mutations at several loci suppress vegetative axillary meristem initiation in pea (2002)

International audience
Chemical transformations of solvent-derived ozonolysis products: acid-catalysed reactions of α-alkoxy α′-hydroperoxy isochromans with aldehydes (1998)

α-(2,2,2-Trifluoroethoxy) α′-hydroperoxy cyclic ethers 6, derived from the ozonolysis of 1-substituted indenes in 2,2,2-trifluoroethanol, undergo acid-catalysed cyclocondensations with aliphatic aldehydes to yield 1,2,4,6-tetroxepanes 8. With formaldehyde, hydroperoxides 6 afford the structurally novel 1,2,4,6,8-pentoxonane derivatives 9 in addition to 1,2,4,6-tetroxepanes. In contrast, the analogous acid-catalysed cyclocondensations involving the isomeric hydroperoxides 7 result in extensive degradation, though acidolysis of hydroperoxides 7 gives rise to the symmetrical 1,2-dialkyl peroxides 16.
Prune Belly Syndrome—Report of 47 Cases (1983)

No AccessJournal of Urology1 Sep 1983Prune Belly Syndrome—Report of 47 Cases C.R.J. Woodhouse, P.G. Ransley, and D. Innes-Williams C.R.J. WoodhouseC.R.J. Woodhouse , P.G. RansleyP.G. Ransley , and D. Innes-WilliamsD. Innes-Williams View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)51375-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Prune Belly Syndrome—Report of 47 Cases." The Journal of Urology, 130(3), p. 631 © 1983 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 130Issue 3September 1983Page: 631 Advertisement Copyright & Permissions© 1983 by The American Urological Association Education and Research, Inc.MetricsAuthor Information C.R.J. Woodhouse More articles by this author P.G. Ransley More articles by this author D. Innes-Williams More articles by this author Expand All Advertisement PDF downloadLoading ...
Surface and interface-influence on photovoltaic conversion efficiency (1983)

The influence of surface and interface recombination on the performance of several types of solar cells is discussed and means to minimise such influence are indicated. A quantitative analysis is presented for a few simplified examples.
Surgery, Complications, and Quality of Life (2018)

Surgical complications alongside other sociodemographic and psychosocial factors contribute to changes in QoL; the results from this exploratory study suggest that interventions that increase the availability of healthcare professional support and promote more effective coping strategies before surgery may be useful, particularly in the earlier stages of recovery where QoL is most severely compromised. However, these relationships should be further explored in longitudinal studies that include other types of surgery and employ rigorous recruitment and follow-up procedures.
Effects of Cu from ZnTe:Cu contacts in CdS/CdTe cells (2002)

CdS/CdTe devices processed with ZnTe:Cu/Ti back contacts are studied as a function of contact deposition temperature between /spl sim/200/spl deg/C and /spl sim/400/spl deg/C. Both the open-circuit voltage (V/sub oc/) and fill factor (FF) increase with temperature. High-resolution secondary ion mass spectroscopy shows Cu concentration in the CdTe region increases due to CdCl/sub 2/ treatment, whereas Cu concentration in the CdS region increases with deposition temperature. Measurements of specific contact resistance suggest that Cu diffusing from the contact interface significantly increases the specific contact resistance at the ZnTe:Cu/Ti interface, resulting in an interface with dominant resistance loss.
Synchronized Blitz: A Lower Bound on the Forwarding Rate of Fully Meshed Traffic in Packet Switches (2010)

The precision of clock oscillators used in packet-based network devices is typically low. Thus, multiple nodes in a packet network, driven by different oscillators may transmit at slightly different port speeds, which may result in significant performance issues. In this paper, we show some of the performance issues that may be caused by clock wander. We use the well known benchmark of fully meshed traffic [RFC 2285] as a test case for analyzing the effect of clock tolerance on the performance of a switching device in a packet based network. We present a framework for analyzing the properties of clock synchronization and its effect on the forwarding rate of a switch. We then present the Synchronized Blitz, an all-to-one scenario where at any given time all incoming traffic into the switch is transmitted to a single port, and show that this scenario consumes more memory resources than any other scenario in our setting. Finally, we present a heuristic formula for a lower bound on the forwarding rate of a switch undergoing a mesh test. The lower bound computation is simple, and provides a useful tool for obtaining intuition about the performance of a device under a mesh test. We conclude by presenting simulation results that demonstrate the previous analysis.
Real-time smoothing filter for three dimensional disparity map algorithm and hardware implementation (2011)

Nowadays, 3D-image processing of stereovision that uses two camera lenses has been a vibrant research filed. This paper proposes an efficient hardware architecture for high performance and real-time smoothing filter that is applicable to enhance the disparity map image from 3D stereovision system. First, we maximally utilized the parallel and pipeline operations. Second, we adopted 11 by 11 sparse mask operations instead of using the 33 by 33 window to achieve faster processing time without sacrificing the quality obtained from 33 by 33 mask operation. Furthermore, our architecture showed faster in processing time and smaller in errors on the images, compared with the normal 33 by 33 mean filter. Our verification was accomplished on the Virtex5 XC5VLX330 FF1760 FPGA of Xilinx with using 100MHz system clock. In a 1280 by 720 video frames, our verification shows that the real-time image was processed with 325fps. Our achievement shows remarkably higher operation rates than the existing ordinary mean filtering method.
Carpal Tunnel Pressures and Wrist Position in Patients with Collesʼ Fractures (1984)

Intracarpal canal interstitial fluid pressures were determined in the wrists of 22 patients with 23 Colles' fractures. Mean values were 18 mm Hg in neutral wrist position, 27 mm Hg in 20 degrees flexion, 47 mm Hg in 40 degrees flexion, and 35 mm Hg in 20 degrees extension. Ten of 23 wrists (45%) had pressures greater than 40 mm Hg in 40 degrees of flexion. Because of the high incidence of median neuropathy associated with immobilization of wrist fractures in a position of marked flexion, an awareness of the magnitude of increased interstitial fluid pressure should lead to alternative methods of treatment in many cases.
An accurate probabilistic model for error detection (2005)

We propose a novel single event fault/error model based on logic induced fault encoded directed acyclic graph (LIFE-DAG) structured probabilistic Bayesian networks, capturing all spatial dependencies induced by the circuit logic. The detection probabilities also act as a measure of soft error susceptibility (an increased threat in nanodomain logic block) that depends on the structural correlations of the internal nodes and also on input patterns. Based on this model, we show that we are able to estimate detection probabilities of single-event faults/errors on IS-CAS'85 benchmarks with high accuracy (zero-error), linear space requirement complexity, and with an order of magnitude (/spl ap/5 times) reduction in estimation time over corresponding BDD based approaches.
Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η (2016)

1,N(6)-Ethenodeoxyadenosine (1,N(6)-ϵdA) is the major etheno lesion formed in the reaction of DNA with epoxides substituted with good leaving groups (e.g. vinyl chloride epoxide). This lesion is also formed endogenously in DNA from lipid oxidation. Recombinant human DNA polymerase η (hpol η) can replicate oligonucleotide templates containing 1,N(6)-ϵdA. In steady-state kinetic analysis, hpol η preferred to incorporate dATP and dGTP, compared with dTTP. Mass spectral analysis of incorporation products also showed preferred purine (A, G) incorporation and extensive -1 frameshifts, suggesting pairing of the inserted purine and slippage before further replication. Five x-ray crystal structures of hpol η ternary complexes were determined, three at the insertion and two at the extension stage. Two insertion complexes revealed incoming non-hydrolyzable dATP or dGTP analogs not pairing with but instead in a staggered configuration relative to 1,N(6)-ϵdA in the anti conformation, thus opposite the 5'-T in the template, explaining the proclivity for frameshift misincorporation. In another insertion complex, dTTP was positioned opposite 1,N(6)-ϵdA, and the adduct base was in the syn conformation, with formation of two hydrogen bonds. At the extension stage, with either an incorporated dA or dT opposite 1,N(6)-ϵdA and 2'-deoxythymidine-5'-[(α,β)-imido]triphosphate opposite the 5'-A, the 3'-terminal nucleoside of the primer was disordered, consistent with the tendency not to incorporate dTTP opposite 1,N(6)-ϵdA. Collectively, the results show a preference for purine pairing opposite 1,N(6)-ϵdA and for -1 frameshifts.
Automated X-Ray Image Annotation Single versus Ensemble of Support Vector Machines (2010)

Abstract. Advances in the medical imaging technology has lead to an exponential growth in the number of digital images that needs to be acquired, analyzed, classified, stored and retrieved in medical centers. As a result, medical image classification and retrieval has recently gained high interest in the scientific community. Despite several attempts, such as the yearly-held ImageCLEF Medical Image Annotation Challenge, the proposed solutions are still far from being sufficiently accurate for real-life implementations. In this paper we summarize the technical details of our experiments for the ImageCLEF 2009 medical image annotation challenge. We use a direct and two ensemble classification schemes that employ local bi-nary patterns as image descriptors. The direct scheme employs a single SVM to automatically annotate X-ray images. The two proposed ensem-ble schemes divide the classification task into sub-problems. The first ensemble scheme exploits ensemble SVMs trained on IRMA sub-codes. The second learns from subgroups of data defined by frequency of classes. Our experiments show that ensemble annotation by training individual SVMs over each IRMA sub-code dominates its rivals in annotation ac-curacy with increased process time relative to the direct scheme. 1
Blue thulium-doped double-clad fiber amplifier by an up-conversion process : Numerical Model (2002)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text P. Lagueux, M. Chamberland, and R. Vallée, "Blue thulium-doped double-clad fiber amplifier by an up-conversion process : Numerical Model," in Advanced Solid-State Lasers, M. Fermann and L. Marshall, eds., Vol. 68 of Trends in Optics and Photonics Series (Optica Publishing Group, 2002), paper MB17. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
On the uniform boundedness of the inertia matrix of serial robot manipulators (1998)

In the control of robot manipulators, it is customary to assume that the eigenvalues of the inertia matrix are uniformly bounded from below and above. However, in this article it is shown that not all manipulators possess this property. The class of serial robot manipulators with bounded inertia matrix, referred to as class ℬ︁𝒟 manipulators, is completely characterized and it is shown that it includes manipulators with nontrivial joint configurations. For manipulators of this class, easily computable uniform bounds for the minimum and maximum eigenvalues of the inertia matrix are provided. © 1998 John Wiley & Sons, Inc. 15: 17–28, 1998
Does interest in language learning affect the non-native phoneme production in elderly learners? (2015)

Second language (L2) learning is widely studied in adult learners. This study was conducted in order to see how auditory training affects elderly learners’ L2 speech production and whether linguistically oriented seniors can benefit more from training compared to seniors not showing special interest in foreign languages. Hence, we studied seniors recruited from language courses and seniors with other than L2 related interests. The two day study included listenand-repeat trainings and production tests. The trained words included vowels from which the three first formants and their standard deviations were measured and analysed. The results showed that formant values changed differently as a function of training in the two groups. Also, the standard deviations developed differently: only the linguistically oriented seniors showed a deviation decrease, indicating non-native learning. This study showed that learning to produce a non-native phoneme can be easier for elderly learners who show a general interest in languages.
Sick Building Syndrome Symptoms among the Staff in Schools and Kindergartens: are the Levels of Volatile Organic Compounds and Carbon Dioxide Responsible? (1996)

From a large questionnaire-based survey investigating the indoor air quality (IAQ) in 48 schools and 74 kindergartens, 21 schools were selected for measurements of volatile organic compounds (VOC) and carbon dioxide (CO2) based on the prevalence of sick building syndrome (SBS) symptoms reported by the staff. The 10 schools with the lowest prevalence of SBS symptoms ‘healthy’) were compared to 11 schools with the highest prevalence (‘sick’; median value showing twice as many SBS symptoms reported). The concentrations of total VOCs (TVOC) in schools and kindergartens were low and within suggested guidelines. The levels of CO2 were higher than suggested guidelines in several cases. However, neither TVOC nor CO2 concentrations were associated with SBS symptoms. Thus, TVOC and CO2 concentrations do not seem to be useful as SBS risk indicators.
An Accelerator-Based Neutron Source for Bnct of Skin Melanoma (1997)

BNCT of skin malignant melanoma bas been developed in Japan since 1972. Primary lesions and unobservable satellite metastasis can be selectively treated with this technique. The clinical results related to 18 patients treated in Japan up to January 1996 are analysed in ref. 1. The survival rate after two or more years resulted to be 78%, regardless the level of melanoma progression. 10B-paraboronphenylanine (BPA) was used as the boron carrier to the tumour. The patiens were irradiated at a research reactor facility for 1-2 hours with thermal neutrons and the related maximum fluences at the tumour sites were in the range (1.0-2.0)x1013 cm-2.The design of the accelerator-based neutron source for BNCT of skin melanoma discussed in the present work is described in ref. 3. Neutrons are produced by bombarding a thick beryllium target with 7 MeV deuterons. The target is contained in a heavy water moderator in turn enclosed in a graphite structure. Lead filters are placed on the Faraday cup containing the beryllium target and on the heavy water container to reduce the prompt gamma ray dose. The experimental verification of the accelerator-based source was performed at the CN Van De Graaff accelerator of the Laboratori Nazionali di Legnaro (LNL, Italy). Measurements of thermal fluence uniformity and prompt gamma ray dose at the irradiation position, together with estimates of the neutron fluences inside an Alderson phantom are discussed in this paper.
Synergistic therapeutic activity of chimeric G250-TNF and IFNγ for the treatment of renal cell cancer (2008)

16009 Background: Renal cell cancer (RCC) is a chemotherapy and radiation resistant disease with high morbidity and mortality when detected at advanced stage. RCC cells express the G250/CAIX antigen at high levels and can be targeted very efficiently with monoclonal antibodies. To deliver human tumor necrosis factor (TNF) we engineered a modified G250 antibody carrying TNF as dimerized CH2/CH3 truncated IgG1-TNF fusion protein which is able to induce TNF-receptor 1 and TNF-receptor 2 dependent bioactivity in a locally restricted manner. Methods: The N-terminal domain of human TNF was linked to the chimeric G250 antibody by molecular engineering. High-level expression of the recombinant fusion protein using NSO cells was achieved with about a 270 mg/l of culture supernatant. Cytotoxicity assays in vitro and biodistribution and efficacy assays in vivo were performed using standard methods. Results: We established an antibody fusion protein that consists of human TNF and chimeric antibody cG250. Bifunctional binding to the G250/CAIX target antigen and the TNR-1/R2 was not altered. Biodistribution studies in G250-positive RCC xenografted BALB/c nu/nu mice demonstrated a significant increase of tumor-to-blood ratios over time, indicating specific accumulation and retention of cG250-TNF at tumor sites. Furthermore, site specific TNF release resulted in growth inhibition of established G250-positive tumors and improved overall- and progression free survival. Anti-tumor activity could be enhanced by co-administration of low doses of non-targeted Interferon-γ (IFNγ) without significant increase of side effects. Administration of cG250-TNF and IFNγ resulted in synergistic biological activity and modulated several key effector components involved in blood coagulation, endothelial damage and angiostasis. Conclusions: The encouraging targeting and anti-tumor activity profile of cG250-TNF and the strong and stable expression pattern of CAIX/G250 in sporadic and inherited forms of RCC warrant clinical evaluation of this construct. No significant financial relationships to disclose.
Development of BLDC Drive for Appliance Applications (2016)

In order to prevent global warming and save resources, there has been a pressing need in recent years to improve the efficiency of home appliance. Appliance applications shuch as washers, dryers, air conditioners, and refrigerators, have long been users of conventional induction motor and DC motor for operating pumps, compressors, blowers fans, and agitators as common example. To meet the increasing demand of energy saving, the induction motor and DC motor in home appliance applications are rapidly being replaved with brushless DC motor. This paper deals primarily with the design aspects of the brushless DC motor drive for appliance applications.