gebhart/patrepeval huggingface dataset:
Streptomyces catbensis sp. nov., isolated from soil (2014)

Strain VN07A0015(T) was isolated from soil collected on Cat Ba Island, Vietnam. The taxonomic position of strain VN07A0015(T) was near Streptomyces aomiensis M24DS4(T) (98.5% 16S rRNA gene sequence similarity) and Streptomyces scabrisporus NBRC 100760(T) (95.6%), and it clustered within them; however, this cluster was distant from the type strains of other species of the genus Streptomyces. The aerial mycelia of strain VN07A0015(T) were greyish and formed imperfect spiral spore chains (retinaculiaperti type) with smooth-surfaced spores. The morphological features of strain VN07A0015(T) were different from those of the type strains of S. aomiensis and S. scabrisporus. The chemotaxonomic characteristics of strain VN07A0015(T) were typical for all members of the genus Streptomyces, which possessed ll-type diaminopimelic acid, menaquinone MK-9(H6, H8) and the major fatty acids iso-C(16 : 0) and iso-C(15 : 0). DNA-DNA relatedness between strain VN07A0015(T) and S. aomiensis NBRC 106164(T) was less than 30%. In addition, some physiological and biochemical traits differed from those of S. aomiensis. Therefore, we propose that strain VN07A0015(T) be classified in the genus Streptomyces as a representative of Streptomyces catbensis sp. nov. (type strain VN07A0015(T) = VTCC-A-1889(T) = NBRC 107860(T)).
Characterization and functional analysis of porcine estrogen-related receptors and their alternative splicing variants1 (2015)

Estrogen-related receptors (ESRR) are orphan nuclear hormone receptors with unidentified ligands; they play important roles in tissue regulation and development and maintenance of pluripotent cell identity. The splicer variant, genomic organization, and physiological roles of ESRR have been elucidated in the human and the mouse. However, in livestock, they remain elusive. In this study, we cloned porcine ESRR family members , , and . Two alternative splicing variants, and , and a novel were identified. To determine the domain function, we constructed vectors with sequential deletions of the ESRRB coding sequence. The functional analysis showed that the C domain of ESRR plays a core role in promoting the activation of estrogen response elements that are found in all kinds of ESRR-targeting genes, whereas the E domain is not essential for transcription regulation of ESRR unless a specific and identified ligand is applied.
Elaboration of immune stimulating lipid-saponin subunit antigen carrier based on glycolipid monogalactosyldiacylglycerol from sea macrophytes and triterpene glycosides from Cucumaria japonica (2013)

The ability of some triterpene glycosides of holothurians: holotoxin A1 from Apostichopus japonicus and a mixture of monosulphated triterpene glycosides from Cucumaria japonica called cucumarioside (CD) to form supramolecular complexes with cholesterol (Chol) and monogalactosyldiacylglycerol (MGDG) or phosphatidylcholine (PC) was studied. A transmission electron microscopy method was used to observe supramolecular lipid-saponin complexes formed by holotoxin A1 and CD with cholesterol in the presence of membrane lipids. The observed supramolecular complexes are tubular nanoparticles with a length of 100-300 nm, an external diameter of 10-16 nm and an internal diameter of 2-6 nm. The formation of tubular nanoparticles was more effective in the presence of MGDG than with PC. Nanoparticles forming in the presence of MGDG are shaped as a tubule, have a constant diameter and a strongly pronounced internal channel. In contrast, PC has no such properties; this lipid is unable to fully integrate in tubular nanoparticles. Based on electron-microscopy data the range of weight ratio of MGDG-Chol-CD was determined as a 1-10:2:3 that provided most effective formation of tubular nanoparticles. Different methods of incorporation of model antigens in complex MGDG-Chol-CD were studied. Influenza haemagglutinin and neuraminidase from commercial vaccine "Influvac" and pore forming protein YompF from Yersinia pseudotuberculosis were used as model antigens. From 54 to 72% of protein of "Influvac" vaccine and 88-92% of YompF were incorporated in supramolecular complexes depending on the method of incorporation. The loss of functional activity of haemagglutinin of vaccine "Influvac" was the result of applying ultrasonic disintegration for incorporation of this protein in complex MGDG-Chol-CD. YompF incorporation in MGDG-Chol-CD complex led to the increased diameter of tubular particles, in the same time incorporation of vaccine "Influvac" antigens produced the "cap" formation at the end of tubules. The possibility of a described supramolecular complex MGDG-Chol-CD to be a carrier for subunit bacterial and viral antigens is shown.
Applicability of dynamic mechanical and thermal methods in investigation of ageing processes of double based rocket propellants (2006)

Ageing of double based rocket propellants (DBR), as a consequence of chemical decomposition reaction, as well as physical processes (migration of low molecular constituents: plasticizers, etc.) has significant influence on their relevant properties (e.g. decrease of molar mass of nitrocellulose, decrease of stabiliser content, decrease of specimen mass, change of mechanical and thermal properties, etc.). The change of relevant properties of DBR propellants limits their safe and reliable service life. Even more, under certain conditions decomposition of a DBR propellant may become autocatalytic, which can lead to self-ignition of the DBR propellant. Because of that, it is very important to find out reliable methods for determination of propellant stability at a given moment of time, as well as to predict self-ignition probability under given conditions. In this work we studied dynamic mechanical and thermal properties of DBR propellants artificially aged for different period of time at 90°C, in order to detect and quantify changes in dynamic mechanical and thermal properties that can be used in the propellants stability assessment. Dynamic mechanical properties were studied by dynamic mechanical analysis (DMA), while thermal properties were studied using differential scanning calorimetry (DSC) and thermogravimetry (TGA). The obtained results showed that the ageing caused significant changes of DMA, DSC and TGA curves’ shape. The changes are quantified by following of some characteristic points on DMA, DSC and TGA curves. It was found out that the most sensitive parameters/characteristic points to the ageing process at DMA curves are: storage modulus at 25 °C, storage modulus at softening region, peak width and height on loss modulus curve, glass transition temperature, loss modulus at viscoelastic region, tan  maximum at viscoelastic region, while the most sensitive parameters at DSC and TGA curves are: peak height and width, heat of reaction, max. heat flow rate, mass loss at a given time, and rate of mass loss at a given time.
Lung density: clinical method for quantitation of pulmonary congestion and edema. (1977)

The density of a defined volume of the human lung can be measured in vivo by a new noninvasive technique. A beam of gamma-rays is directed at the lung and, by measuring the scattered gamma-rays, lung density is calculated. The density in the lower lobe of the right lung in normal man during quiet breathing in the sitting position ranged from 0.25 to 0.37 g.cm-3. Subnormal values were found in patients with emphsema. In patients with pulmonary congestion and edema, lung density values ranged from 0.33 to 0.93 g.cm-3. The lung density measurement correlated well with the findings in chest radiographs but the lung density values were more sensitive indices. This was particularly evident in serial observations of individual patients.
Trends in consumer communications [Series Editorial] (2012)

This issue of the Consumer Communications and Networking series, featuring four articles, touches on four different aspects of emerging technologies from radio communications in a digital home to workflow management in connected smart homes and inter-destination synchronization for multimedia applications to mobile application stores. Let us look into the details of each article.
The use of antibodies labelled with dyes for fast and simple assay of some human proteins by immunofiltration technique. (1992)

Immunofiltration technique with polyclonal and monoclonal antibodies for semi-quantitative assays of human albumin, chorionic gonadotropin, immunoglobulin G and transferrin was elaborated. An amount of antibody was immobolized in the form of 6 radially located small bars on a dry test filter made of glass microfibre sheet. The other amount of antibody, used in solution, was labelled with some dyes like commercial disperse dyes, colloidal elements, formazans and polypyrrole. Number of colour bars appearing on the test filter showed ranged of analyte concentration. Good results were obtained using antibodies labelled with colloidal gold, Disperse Red 11 and formazan from MTT. Assays with monoclonal antibodies were more sensitive than with polyclonal antibodies.
Case Report: Whole exome sequencing reveals a novel frameshift deletion mutation p.G2254fs in COL7A1 associated with autosomal recessive dystrophic epidermolysis bullosa (2016)

<ns4:p> Dystrophic epidermolysis bullosa simplex (DEB) is a phenotypically diverse inherited skin fragility disorder. It is majorly manifested by appearance of epidermal bullae upon friction caused either by physical or environmental trauma. The phenotypic manifestations also include appearance of milia, scarring all over the body and nail dystrophy. DEB can be inherited in a recessive or dominant form and the recessive form of DEB (RDEB) is more severe. In the present study, we identify a novel p.G2254fs mutation in <ns4:italic>COL7A1</ns4:italic> gene causing a sporadic case of RDEB by whole exome sequencing (WES). Apart from adding a novel frameshift Collagen VII mutation to the repertoire of known mutations reported in the disease, to the best of our knowledge, this is the first report of a genetically characterized case of DEB from India. </ns4:p>
Relating the Structure of<i>HIV-1 Reverse Transcriptase</i>to Its Processing Step (2000)

Abstract By treating an enzyme as a coarse-grained uniform block of material, utilizing only the α-Carbon positions, the normal modes of motion can be obtained. For reverse transcriptase the slower of these motions are suggestive of being involved in the processing step, where the RNA or DNA strand is copied onto a new DNA strand at a polymerase site, and the RNA strand is subsequently cut up at the distant Ribonuclease H site. The slowest mode of motion involves hinge bending about a site midway between the polymerase and Ribonuclease H sites, suggesting that it can push or pull the RNA strand between these two sites. Pulling the nucleic acid strand would require tight binding to the RNase H site. The next slowest mode involves a hinge that opens and closes the protein like a clamp, which could facilitate the release of the nucleic acids for their step-wise progression. The third mode could rotate the substrate. An overall description of the step-wise processing step would involve close coordination among these steps. Results suggest that the smaller p51 subunit serves only as ballast to support the various modes of motion involving the different parts of the p66 subunit.
Marked Elevation of Serum Interleukin-6 in Patients With Cholangiocarcinoma (1998)

In selected patients, a high serum level of IL-6 marks patients with CC and correlates with tumor burden both before and after resection. IL-6 levels are elevated in patients with other liver neoplasms and may distinguish patients with hepatic malignancies from those with benign disease.
Pseudogene Associated Recurrent Gene Fusion in Prostate Cancer (2019)

We present the functional characterization of a pseudogene associated recurrent gene fusion in prostate cancer. The fusion gene KLK4-KLKP1 is formed by the fusion of the protein coding gene KLK4 with the noncoding pseudogene KLKP1. Screening of a cohort of 659 patients (380 Caucasian American; 250 African American, and 29 patients from other races) revealed that the KLK4-KLKP1 is expressed in about 32% of prostate cancer patients. Correlative analysis with other ETS gene fusions and SPINK1 revealed a concomitant expression pattern of KLK4-KLKP1 with ERG and a mutually exclusive expression pattern with SPINK1, ETV1, ETV4, and ETV5. Development of an antibody specific to KLK4-KLKP1 fusion protein confirmed the expression of the full-length KLK4-KLKP1 protein in prostate tissues. The in vitro and in vivo functional assays to study the oncogenic properties of KLK4-KLKP1 confirmed its role in cell proliferation, cell invasion, intravasation, and tumor formation. Presence of strong ERG and AR binding sites located at the fusion junction in KLK4-KLKP1 suggests that the fusion gene is regulated by ERG and AR. Correlative analysis of clinical data showed an association of KLK4-KLKP1 with lower preoperative PSA values and in young men (<50 years) with prostate cancer. Screening of patient urine samples showed that KLK4-KLKP1 can be detected noninvasively in urine. Taken together, we present KLK4-KLKP1 as a class of pseudogene associated fusion transcript in cancer with potential applications as a biomarker for routine screening of prostate cancer.
Modeling of Quantum Effects in Ultrasmall HEMT (1993)

Numerical simulation of ultra-submicrometer high electron mobility transistors based upon a set of quantum mo- ment equations is presented. These provide a first quantum de- scription, based upon the moments of the Wigner distribution function. In HEMT's, the conduction electrons are confined in a narrow conduction channel and the short gate lengths (and small aspect ratio) create different potential barriers across the conduction channel than in a long-channel situation. In these small structures, quantum effects are expected to be promi- nent. A substantial change in the electron density distribution is found to occur due to the inclusion of these quantum correc- tions, and the total current in the simulated devices is increased by as much as 10% for a 24-nm gate-length device.
Proceedings of the first world conference on structural control [Book Review] (1996)

The subject of structural control deals with modifying
the response of structures to undesirable motions that
are produced by earthquake, wind or man-made forces. In the case of wind forces, the motions are usually of small amplitude caused by moderate gusts but are objectionable
to the tenants of the upper floors. Various methods of control have been employed, including introducing damping, installing moveable masses on the upper floor, etc.
ChemInform Abstract: AN UNAMBIGUOUS SYNTHESIS OF PYRAZOLES BY SULFUR EXTRUSION FROM 1,2,6‐THIADIAZINES (1981)

Abstract Die Diimine (I) reagieren mit Thionylchlorid bzw. mit S,Cl, oder SCI, zu den l,2,6‐Thiadiazin‐S‐oxiden (II) bzw. zu den l,2,6‐Thiadiazinen (III), die beide bei der Oxidation mit m‐Chlorbenzoesäure die gleichen entsprechenden Produkte, die l,2,6‐ Thiadiazin‐S‐dioxide (IV), liefern,die kein SO, abspalten.
Position paper of Italian rheumatologists on the use of biosimilar drugs. (2015)

The recent availability of biosimilars as a result of the expiry of the patents of first-generation biotechnological drugs may theoretically reduce the direct costs of such treatments, making their use accessible to a larger number of patients. However, the currently available clinical data refer to a relatively small number of patients, and do not provide sufficient information concerning long-term efficacy and safety or the frequency of rare adverse events. Given the importance of the introduction of biosimilar drugs and the limitations of our current knowledge of their efficacy and safety profiles, we believe it is mandatory to draw up a position paper for Italian Rheumatologists. Moreover, in order to guarantee their safety, it is mandatory to indicate behavioural rules for the involved specialists and competent authorities, and perform ad hoc clinical trials and appropriate drug surveillance.
Environmentally Responsible Aviation - Real Solutions for Environmental Challenges Facing Aviation (2010)

The combined reality of persistently strong growth in air traffic and the vital economic role of the air transport system result in continued demand for the progress of technology for the reduction of aircraft noise, emissions of oxides of nitrogen, and fuel burn. NASA s Environmentally Responsible Aviation (ERA) project has set aggressive goals in these three areas including a noise goal of 42 dB cumulative below the Stage 4 certification level. The goal for the reduction of oxides of nitrogen is 75% below the current standard. The fuel burn reduction goal is 50% below that of a current state-of-the-art aircraft. Furthermore, the overall goal of ERA is to mature technologies that will meet these goals simultaneously and with a timeframe of 2020 for technical readiness. This paper outlines the key technologies and the progress achieved to date toward the goals.
Observation of the decay<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mi>B</mml:mi></mml:mrow><mml:mrow><mml:mn>0</mml:mn></mml:mrow></mml:msup></mml:mrow><mml:mo>→</mml:mo><mml:mrow><mml:msup><mml:mrow><mml:mi>ρ</mml:mi></mml:mrow><mml:mrow><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:mrow><mml:mrow><mml:msup><mml:mrow><mml:mi>ρ</mml:mi></mml:mrow><mml:mrow><mml:mi>−</mml:mi></mml:mrow></mml:msup></mml:mrow></mml:math>and measurement of the branching fraction and polarization (2004)

We have observed the rare decay ${B}^{0}\ensuremath{\rightarrow}{\ensuremath{\rho}}^{+}{\ensuremath{\rho}}^{\ensuremath{-}}$ in a sample of 89 million $B\overline{B}$ pairs recorded with the $\mathit{BABAR}$ detector. The number of observed events is ${88}_{\ensuremath{-}21}^{+23}\ifmmode\pm\else\textpm\fi{}9,$ with a significance of 5.1 standard deviations with systematic uncertainties included. The branching fraction and the longitudinal polarization are measured to be $\mathcal{B}{(B}^{0}\ensuremath{\rightarrow}{\ensuremath{\rho}}^{+}{\ensuremath{\rho}}^{\ensuremath{-}}{)=(25}_{\ensuremath{-}6\ensuremath{-}6}^{+7+5})\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}6}$ and ${\ensuremath{\Gamma}}_{L}/\ensuremath{\Gamma}{=0.98}_{\ensuremath{-}0.08}^{+0.02}\ifmmode\pm\else\textpm\fi{}0.03,$ respectively.
Drugs derived from cannabinoids. Part 8. The synthesis of side-chain analogues of Δ<sup>6a,10a</sup>-tetrahydrocannabinol (1981)

The continuation of studies on the synthesis of side-chain analogues of Δ6a,10a-tetrahydrocannabinol as potential therapeutic agents has led to the syntheses of a possible metabolite 1-hydroxy-6,6,9-trimethyl-7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyran-3-ylacetic acid (1) and 2-(1-hydroxy-6,6,9-trimethyl-7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyran-3-yl)pent-4-ynioc acid (17c). The Pechmann condensation of ethyl 4-methyl-2-oxocyclo-hexane-1-carboxylate with methyl 3,5-dihydroxyphenylacetate (11), followed by Grignard reaction, was utilized to produce the pyran (1). The key step in the synthesis of the propargylacetic acid (17c) was propargylation of the malonate (15) under phase-transfer catalysis.
ChemInform Abstract: Formation of Cyclic Ketene N‐Hydroxyaminals, 2‐Acylmethylene‐1‐hydroxyimidazolidines, in the Reaction of 1,2‐Bishydroxylamines with 1,3‐Ketoaldehydes. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Synthesis of N‐Substituted‐2‐alkyl(or aryl)quinazolin‐4‐amines by Amide Base‐Mediated Cyclization of Carboximidamides Derived from 2‐(Trifluoromethyl)benzenamine. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Projections from the periaqueductal gray to the rostromedial pericoerulear region and nucleus locus coeruleus: Anatomic and physiologic studies (1991)

Previous studies showed that the nucleus locus coeruleus (LC) receives two major afferent inputs from 1) nucleus paragigantocellularis and 2) nucleus prepositus hypoglossi, both in the rostral medulla. Recent reports suggested that the midbrain periaqueductal gray (PAG) projects to the rostromedial pericoerulear area and LC. Since the PAG is a major site for control of central antinociception, and since descending noradrenergic fibers have been implicated in pain modulation, we have investigated in detail the functional anatomy of projections from PAG to the dorsolateral pontine tegmentum. A combined anatomical and electrophysiological approach was used to assess the organization and synaptic influence of PAG on neurons in the rostromedial pericoerulear region and in LC proper. Injections of the tracer wheatgerm agglutinin conjugated to horseradish peroxidase encompassing LC proper and the rostromedial pericoerulear area retrogradely labeled neurons in PAG located lateral and ventrolateral to the cerebral aqueduct; injections restricted to LC proper did not consistently label PAG neurons. Deposits of the anterograde axonal tracer Phaseolus vulgaris leucoagglutinin into this same region of PAG labeled axons that robustly innervated the zone rostral and medial to LC. Only sparse fibers were observed in LC proper. Consistent with these results, focal electrical stimulation of LC antidromically activated only a few PAG neurons (6 of 100); all of these driven cells were located lateral and ventrolateral to the cerebral aqueduct. The majority of neurons in the rostromedial pericoerulear area were robustly activated by single pulse stimulation of PAG. In contrast, single pulse electrical stimulation of lateral PAG produced weak to moderate synaptic activation of some LC neurons; stimulation of ventrolateral PAG produced predominant inhibition of LC discharge, perhaps through recurrent collaterals subsequent to antidromic activation of neighboring LC cells. Taken together, these results indicate that PAG strongly innervates the region rostral and medial to LC, including Barrington's nucleus, but only weakly innervates LC proper. Although recent studies indicate that the dendrites of LC neurons ramify heavily and selectively in the rostromedial pericoerulear region, the results of the present physiological studies suggest that PAG preferentially targets rostromedial pericoerulear neurons rather than LC dendrites.