gebhart/patrepeval huggingface dataset:
Correction - Gas Chromatography and Mass Spectrometry of Spingolipid Bases. Charcterization of Sphinga-4,14-dienine from Plasma Shingomyelin (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleCorrection - Gas Chromatography and Mass Spectrometry of Spingolipid Bases. Charcterization of Sphinga-4,14-dienine from Plasma ShingomyelinAlan J. Polito, Tadashi. Akita, and Charles C. SweeleyCite this: Biochemistry 1968, 7, 9, 3316Publication Date (Print):September 1, 1968Publication History Published online3 November 2003Published inissue 1 September 1968https://pubs.acs.org/doi/10.1021/bi00849a602https://doi.org/10.1021/bi00849a602research-articleACS PublicationsRequest reuse permissionsArticle Views14Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hypersonic Absorption in Quartz at Temperatures Below 30°K (1964)

We have extended earlier absorption measurements between 500 and 10 000 Mc/sec to temperatures below 30\ifmmode^\circ\else\textdegree\fi{}K where the mean free path of thermal phonons is likely to be larger than the ultrasonic wave-length. The absorption of transverse waves follows in magnitude, as well as in the dependence on temperature and frequency, as expected for a three-phonon process. However, the measured absorption per cm for longitudinal waves depends only slightly on frequency in contrast to the expectations for a four-phonon process; instead it supports a different absorption mechanism discussed here in detail. Finally, experiments with imperfect and neutron-irradiated quartz are reported in which strong additional absorption appears, which may be related to the absorption in fused quartz.
Über Metalltrifluorphosphin‐Komplexe, XX. Direktsynthesen von Trifluorphosphinkomplexen des Kobalts sowie des Nickels und seiner Homologen (1968)

Abstract Während Platinpulver mit hohen PF 3 ‐Drucken nur bei Zusatz von z. B. Jod spurenweise den Komplex Pt(PF 3 ) 4 liefert, lassen sich die homologen Tetrakis(trifluorphosphine) M(PF 3 ) 4 von Palladium(O) und Nickel(O) leicht und quantitativ aus dem Metall schon unter relativ niedrigen PF 3 ‐Drucken darstellen. Ebenfalls quantitativ entsteht das komplexe Kobalt‐hydrid HCo(PF 3 ) 4 aus den Elementen und dem Phosphinliganden unter Druck.
Intraductal Papillary Mucinous Neoplasm of the Pancreas (2016)

With the widespread use and advances in radiographic imaging, Intraductal Papillary Mucinous Neoplasms (IPMNs) of the pancreas are identified with increasing frequency. Although many studies have addressed its biology and treatment, true understanding of its natural history continues to elude us. Its malignant potential places careproviders in a clinical dilemma of balancing the morbidity of pancreatectomy against the risk of malignant transformation while under continuous surveillance. Recently, there have been conflicting data published in the literature, generating more uncertainty in the field. In this article, we critically analyze the contrasting consensus guidelines from the International Association of Pancreatology and the American Gastroenterology Association, and address lingering questions and controversies. We also synthesize newly published data in the context of current standard of care, and provide a comprehensive review and recommendations for the clinical diagnosis, treatment, and follow-up strategy in the management of patients with Intraductal Papillary Mucinous Neoplasms.
Temporalis Fascia Graft Forceps (1966)

Since Storrs, 1 Ortegren, 2 and Heermann 3 started to use temporalis fascia graft for tympanic membrane reconstruction, this material received worldwide acceptance. There are different ways to obtain and prepare this tissue for tympanic membrane graft. The following is a description of a new instrument which is useful in obtaining and preparing the fascia. From a postaural incision, the temporalis muscle is exposed, and a layer of fascia sheet is dissected with small curved scissors. This instrument, which is shown in the Figure, is then opened and inserted so that the fascia is between the two prongs of the instrument. Then the instrument is closed, and with a small curved eye scissors, the fascia is cut around the instrument. Then the forceps with the stretched membrane is put aside for about two hours. After this, the instrument is opened, and the cup-shaped graft is removed from the Teflon disc
Chemical Cell-Surface Receptor Engineering Using Affinity-Guided, Multivalent Organocatalysts (2011)

Catalysts hold promise as tools for chemical protein modification. However, the application of catalysts or catalyst-mediated reactions to proteins has only recently begun to be addressed, mainly in in vitro systems. By radically improving the affinity-guided DMAP (4-dimethylaminopyridine) (AGD) catalysts that we previously reported (Koshi, Y.; Nakata, E.; Miyagawa, M.; Tsukiji, S.; Ogawa, T.; Hamachi, I. J. Am. Chem. Soc. 2008, 130, 245.), here we have developed a new organocatalyst-based approach that allows specific chemical acylation of a receptor protein on the surface of live cells. The catalysts consist of a set of 'multivalent' DMAP groups (the acyl transfer catalyst) fused to a ligand specific to the target protein. It was clearly demonstrated by in vitro experiments that the catalyst multivalency enables remarkable enhancement of protein acylation efficiency in the labeling of three different proteins: congerin II, a Src homology 2 (SH2) domain, and FKBP12. Using a multivalent AGD catalyst and optimized acyl donors containing a chosen probe, we successfully achieved selective chemical labeling of bradykinin B(2) receptor (B(2)R), a G-protein coupled receptor, on the live cell-surface. Furthermore, the present tool allowed us to construct a membrane protein (B(2)R)-based fluorescent biosensor, the fluorescence of which is enhanced (tuned on) in response to the antagonist ligand binding. The biosensor should be applicable to rapid and quantitative screening and assay of potent drug candidates in the cellular context. The design concept of the affinity-guided, multivalent catalysts should facilitate further development of diverse catalyst-based protein modification tools, providing new opportunities for organic chemistry in biological research.
Lack of Withdrawal Signs of Dependence following Cessation of Treatment or Ro-15,1788 Administration to Rats Chronically Treated with Buspirone (1986)

Failure to gain weight during withdrawal from chronic regimens of dependence-producing drugs is observed in laboratory rats. Withdrawal from the benzodiazepine anxiolytic agent diazepam, whether induced by cessation of treatment or precipitated by administration of the specific benzodiazepine antagonist Ro-15,1788, is accompanied by weight loss. However, the same withdrawal treatments following a chronic regimen of equal doses of the nonbenzodiazepine antianxiety drug buspirone are not associated with weight loss. Buspirone-treated rats gain weight during withdrawal, suggesting that this novel anxiolytic should lack dependence liability in man.
Acetate catabolism by Methanosarcina barkeri: evidence for involvement of carbon monoxide dehydrogenase, methyl coenzyme M, and methylreductase (1985)

The pathway of acetate catabolism in Methanosarcina barkeri strain MS was studied by using a recently developed assay for methanogenesis from acetate by soluble enzymes in cell extracts. Extracts incubated with [2-14C]acetate, hydrogen, and ATP formed 14CH4 and [14C]methyl coenzyme M as products. The apparent Km for acetate conversion to methane was 5 mM. In the presence of excess acetate, both the rate and duration of methane production was dependent on ATP. Acetyl phosphate replaced the cell extract methanogenic requirement for both acetate and ATP (the Km for ATP was 2 mM). Low concentrations of bromoethanesulfonic acid and cyanide, inhibitors of methylreductase and carbon monoxide dehydrogenase, respectively, greatly reduced the rate of methanogenesis. Precipitation of CO dehydrogenase in cell extracts by antibodies raised to 95% purified enzyme inhibited both CO dehydrogenase and acetate-to-methane conversion activity. The data are consistent with a model of acetate catabolism in which methylreductase, methyl coenzyme M, CO dehydrogenase, and acetate-activating enzymes are components. These results are discussed in relation to acetate uptake and rate-limiting transformation mechanisms in methane formation.
The preparation and performance of “Cage” diphosphites as secondary antioxidants in the stabilization of polyolefins (1997)

Abstract “Cage” diphosphites, a new family of phosphorus antioxidants, are discussed in regard to their preparation, properties, and effectiveness in polyolefins, particularly, with phenolic stabilizers, in respect to their ability to control melt flow and color during processing. These trivalent phosphorus compounds have two different types of phosphite functionalities in their structure. One phosphorus is part of an eight membered (1,3,2‐dioxaphosphocine) ring system while the other is part of a tricyclic cage of carbon and oxygen atoms. This structures can contribute to improved hydrolytic stability over rather similar aryloxy‐alkoxy phosphites and show competitive stabilization effectiveness in the processing of polyolefins. The possible modes of formation and of hydrolysis are discussed.
Analytic Derivation of Static Pressure Distribution in Fully Developed Helical Flows (1978)

Research Papers Analytic Derivation of Static Pressure Distribution in Fully Developed Helical Flows T. M. Kuzay T. M. Kuzay RAS, Argonne National Laboratory, Argonne, Ill. Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information T. M. Kuzay RAS, Argonne National Laboratory, Argonne, Ill. J. Fluids Eng. Jun 1978, 100(2): 201-203 (3 pages) https://doi.org/10.1115/1.3448630 Published Online: June 1, 1978 Article history Received: May 3, 1976 Online: October 12, 2010
Electrochemical Impedance Techniques in Corrosion Science (1981)

A review is presented of the use of impedance techniques in corrosion science. Emphasis is placed on defining the type of data that is required in corrosion studies, and then comparing different methods for generating the required information by electrochemical impedance methods. The performance characteristics of the various techniques, including cost, are critically compared to assist readers in selecting the most appropriate system for their needs.
Characteristics of low threshold 1.3 μm lasers grown by solid source molecular beam epitaxy (2002)

We report on the growth and characterization of high quality 1.3 /spl mu/m lasers grown by SSMBE with various laser structures and core materials. Our best 1.3 /spl mu/m lasers utilize compressively strained InAsP/GaInAsP quantum wells. Compressive strain serves to decrease the heavy hole effective mass which reduces the density of states of the valence band resulting in lower threshold currents as compared to lattice matched devices. The room temperature photoluminescence and threshold current density versus inverse cavity length are shown.
From sadness to senescence: cellular effects of psychiatric syndromes (2012)

Rationale/statement of the problem : Major depressive disorder (MDD) and other serious mental illnesses are associated with high rates of comorbid medical illnesses. Many of these comorbid conditions are more typically seen in the aged, raising the possibility that these psychiatric illnesses are associated with accelerated aging. An emerging biomarker of cell aging and of increased risk of medical illness is leukocyte telomere length, and several studies have now characterized leukocyte telomere length in MDD and other psychiatric illnesses. Fewer psychiatric studies have characterized the activity of telomerase, an enzyme that can elongate and preserve telomeric DNA, or have investigated the biochemical mediators of accelerated telomere shortening. Methods : Seven studies examining telomere length in MDD, three studies in schizophrenia, two studies in bipolar illness, two studies in PTSD, and one study in generalized anxiety disorder were reviewed, as were one study of telomerase activity in MDD and one study in schizophrenia. Additional studies in chronically stressed individuals and in individuals with histories of childhood adversity were also reviewed. Results : Shortened leukocyte telomeres have been demonstrated in MDD, bipolar illness, schizophrenia, anxiety disorders, and post-traumatic stress disorder, although in some studies, only subgroups of patients (e.g., those with longer lifetime exposure to the illness, those with poor responses to treatment, or those with preexisting histories of childhood adversity) showed shortened telomeres. Leukocyte telomere shortening is correlated with peripheral indices of increased oxidative stress and increased immune activation. Two studies (one in caregivers with high depression ratings and one in unmedicated patients with MDD) reported elevated peripheral blood mononuclear cell (PBMC) telomerase activity, perhaps representing a compensatory attempt by the body to preserve endangered telomeres. Preliminary data in MDD suggest that relatively low telomerase activity before treatment, and greater treatment-associated increases in telomerase activity, are associated with better antidepressant responses. This, plus the preliminary observation that PBMC telomerase activity is directly correlated with hippocampal volume (by MRI) in MDD, support emerging preclinical data that telomerase has intrinsic neurotrophic and antidepressant effects. Conclusion : Telomere shortening in MDD and certain other psychiatric conditions may, at least partially, reflect chronic exposure to inflammation and oxidation. As such, it may be a bellwether of increased medical risk, or it may play a more direct causal role in accelerated aging. The interplay of telomere integrity and telomerase activity may be an important determinant of psychiatric and medical outcome. Overall, the data are consistent with the view that MDD and certain other psychiatric illnesses have systemic manifestations beyond the brain and call into question the dichotomy of “mental” vs. “physical” illnesses.
Substituent Effect on Organotin Tp* Compounds as the Tp* Reagent for the Preparation of Mono Tp* Complexes of Group 4—6 Metals (Tp* = Tris(3,5-dimethylpyrazol-1-yl)hydroborate) (2000)

Abstract Organotin compounds [Tp*SnCl3-nBun] (2: n = 1; 3: n = 2) having a Tp* ligand (Tp* = tris(3,5-dimethylpyrazol-1-yl)hydroborate) are useful reagents for introducing a Tp* ligand on Group 4 and 5 metals and chromium. The test reactions of these organotin compounds along with [Tp*SnCl3] (1) with ZrCl4, affording a known complex [Tp*ZrCl3] (4), were examined. The reaction rates were in the order 3 &gt; 2 1. This tendency was understood by the average Sn-N(Tp* ligand) bond distance being longer in the order 3 &gt; 2 &gt; 1 as revealed by the crystallographic studies and the orbital interactions between the Tp* ligand and the SnCl3-nBun fragments estimated by the ab initio calculations for 1—3. On the basis of the above findings, we applied the compound 3 to prepare Tp* complexes of Group 4—6 metals. Reactions of TiCl4 with an equimolar amount of 3 afforded [Tp*TiCl3] (7) in good yields after a simple rinse to remove the resulting tin compound, SnBu2Cl2. [Tp*HfCl3] (8) was prepared in moderate yield by reaction of [HfCl4(THF)2] with 3 under severe conditions. Similarly, the reactions of 3 with a stoichiometric amount of [NbCl4(THF)2] or [NbCl5(OEt)2] and TaCl5 in toluene gave [Tp*NbCl3] (9) and [Tp*TaCl3][TaCl6] (10), respectively. We also applied our synthetic method to prepare Tp* complexes of vanadium, [Tp*VCl2(THF)] (11), [Tp*VCl2(DNAP)] (12) (DMAP = 4-dimethylaminopyridine), and [Tp*VCl2(=NC6H3Me2-2,6)] (13) and those of chromium, [Tp*CrCl2(L)] (14: L = THF; 15: L = H2O; 16: L = DMAP). Some of these Tp* complexes, 4, 8, 12, 13, 15, and 16 were crystallographically characterized to have discrete octahedral geometry containing the facial coordination of the Tp* ligand.
Invariant NK T Cells: Potential for Immunotherapeutic Targeting with Glycolipid Antigens (2010)

Invariant NK T (iNKT) cells are a subset of T lymphocytes that recognize glycolipid antigens bound with the antigen-presenting molecule CD1d. iNKT cells have potent immunoregulatory activities that can promote or suppress immune responses during different pathological conditions. These immunoregulatory properties can be harnessed for therapeutic purposes with cognate glycolipid antigens, such as the marine sponge-derived glycosphingolipid α-galactosylceramide. Preclinical studies have shown substantial promise for iNKT cell-based treatments of infections, cancer and autoimmune and inflammatory diseases. Translation of these preclinical studies to the clinic, while faced with some obstacles, has already had some initial success. In this article, we review the immunodulatory activities of iNKT cells and the potential for developing iNKT cell-based prophylactic and curative therapies of human disease.
Site selection of metal complexation in the semibullvalene skeleton. Exigencies of palladation (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSite selection of metal complexation in the semibullvalene skeleton. Exigencies of palladationR. M. Moriarty, C. L. Yeh, K.-N. Chen, E. L. Yeh, K. C. Ramey, and C. W. JeffordCite this: J. Am. Chem. Soc. 1973, 95, 14, 4756–4758Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://pubs.acs.org/doi/10.1021/ja00795a050https://doi.org/10.1021/ja00795a050research-articleACS PublicationsRequest reuse permissionsArticle Views71Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of potential for MSRE spent fuel and flush salt storage and treatment at the INEL (1996)

The potential for interim storage as well as for treatment of the Molten Salt Reactor Experiment spent fuel at INEL has been evaluated. Provided that some minimal packaging and chemical stabilization prerequisites are satisfied, safe interim storage of the spent fuel at the INEL can be achieved in a number of existing or planned facilities. Treatment by calcination in the New Waste Calcining Facility at the INEL can also be a safe, effective, and economical alternative to treatment that would require the construction of a dedicated facility. If storage at the INEL is chosen for the Molten Salt Reactor Experiment (MSRE) spent fuel salts, their transformation to the more stable calcine solid would still be desirable as it would result in a lowering of risks. Treatment in the proposed INEL Remote-Handled Immobilization Facility (RHIF) would result in a waste form that would probably be acceptable for disposal at one of the proposed national repositories. The cost increment imputable to the treatment of the MSRE salts would be a small fraction of the overall capital and operating costs of the facility or the cost of building and operating a dedicated facility. Institutional and legal issues regarding shipments of fuel and waste to the INEL are summarized. The transfer of MSRE spent fuel for interim storage or treatment at the INEL is allowed under existing agreements between the State of idaho and the Department of energy and other agencies of the Federal Government. In contrast, current agreements preclude the transfer into Idaho of any radioactive wastes for storage or disposal within the State of Idaho. This implies that wastes and residues produced from treating the MSRE spent fuel at locations outside Idaho would not be acceptable for storage in Idaho. Present agreements require that all fuel and high-level wastes stored at the INEL, including MSRE spent fuel if received at the INEL, must be moved to a location outside Idaho by the year 2035.
Anti-tumor Promoting Activity of Bufadienolides from Kalanchoe pinnata and K. daigremontiana × butiflora (2001)

Five bufadienolides (1-5) isolated from the leaves of Kalanchoe pinnata and K. daigremontiana x tubiflora (Crassulaceae) were examined for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. All bufadienolides showed inhibitory activity, and bryophyllin A (1) exhibited the most marked inhibition (IC50 = 0.4 microM) among the tested compounds. Bryophyllin C (2), a reduction analogue of 1, and bersaldegenin-3-acetate (3) lacking the orthoacetate moiety were less active. These results strongly suggest that bufadienolides are potential cancer chemopreventive agents.
Comparative Proteomic Analysis of Drug Trichosanthin Addition to BeWo Cell Line (2022)

Trichosanthin (TCS) is a traditional Chinese herbal medicine used to treat some gynecological diseases. Its effective component has diverse biological functions, including antineoplastic activity. The human trophoblast cell line BeWo was chosen as an experimental model for in vitro testing of a drug screen for anticancer properties of TCS. The MTT method was used in this study to get a primary screen result. The result showed that 100 mM had the best IC<sub>50</sub> value. Proteomics analysis was then performed for further investigation of the drug effect of TCS on the BeWo cell line. In this differential proteomic expression analysis, the total proteins extracted from the BeWo cell line and their protein expression level after the drug treatment were compared by 2DE. Then, 24 unique three-fold differentially expressed proteins (DEPs) were successfully identified by MALDI-TOF/TOF MS. Label-free proteomics was run as a complemental method for the same experimental procedure. There are two proteins that were identified in both the 2DE and label-free methods. Among those identified proteins, bioinformatics analysis showed the importance of pathway and signal transduction and gives us the potential possibility for the disease treatment hypothesis.