gebhart/patrepeval huggingface dataset:
PROYECTO PARA TRATAR ALZHEIMER CON SUSTANCIAS DEL PULPO ROJO. INVESTIGACIÓN EN SISAL, YUCAT N (2012)

SERGIO RODRIGUEZ MORALES COLABORA EN UN PROYECTO MULTIDISCIPLINARIO DESARROLLADO EN LA UNIDAD QUIMICA DE LA FACULTAD DE QUIMICA DEL CAMPUS SISAL, CON APOYO DE LA UNAM Y FONDO MIXTO DEL ESTADO DE YUCATAN, EN QUE ESTUDIAN LOS EFECTOS DE LOS EXTRACTOS DE LAS GLANDULAS SALIVALES DEL PULPO ROJO PARA SEPARAR MOLECULAS QUE PUEDAN AYUDAR A COMBATIR ALZHEIMER. LA PESQUERIA DE ESTE ANIMAL, ENDEMICO DE LA PENINSULA DE YUCATAN, GENERA CINCO MIL EMPLEOS Y UNA DERRAMA ECONOMICA DE 20 MILLONES DE DOLARES AL ANO. DE HECHO, ENTRE AGOSTO Y DICIEMBRE TODA LA PESQUERIA DE LA REGION CENTRA EN ESTA OCUPACION Y PRODUCE UNA COLECTA DE ENTRE 15 Y 16 TONELADAS ANUALES. UNA VEZ CAPTURADO, 15 POR CIENTO DEL PESO TOTAL DEL INVERTEBRADO ELIMINADO (ENTRE VISCERAS, CEREBRO Y APARATOO DIGESTIVO). HAY INVESTIGACIONES ORIENTADAS A UTILIZAR ESTOS SUBPRODUCTOS EN LA ELABORACION DE ALIMENTOS PARA MASCOTAS. DE ESE DESPERDICIO DE UNAS MIL TONELADAS, LOS INVESTIGADORES DE LA UNAM UTILIZAN LAS GLANDULAS SALIVALES YA QUE CONTIENEN POLIPEPTIDOS NEUROTOXICOS QUE PUEDEN AYUDAR A CURAR ALZHEIMER. PROPOSITO USAR EFICIENTEMENTE ESOS RECURSOS. SE DESCONOCE GRAN PARTE DE LA BIOLOGIA O CONSTITUCION QUIMICA DE ESTA CRIATURA, COMO ALIMENTA Y LAS ESPECIES DE QUE VALE PARA VIVIR. DE OTRAS VARIEDADES DE OCTOPODOS, COMO 'ELEDONA MOSCHATA', HA LOGRADO AISLAR LA ELEDOISINA, POLIPEPTIDO QUE REDUCE LA PRESION ARTERIAL, UTILIZADO PARA TRATAR SINDROME DE SJ”GREN, QUE CAUSA LA AUSENCIA DE LAGRIMAS, REFIRIO RODRIGUEZ MORALES. DETALLO QUE OBJETIVO PRINCIPAL DE LA INVESTIGACION ENCONTRAR MOLECULAS DE ORGANISMOS MARINOS QUE TENGAN EFECTO SOBRE LA SALUD, EN PARTICULAR NEUROPEPTIDOS DEL PULPO ROJO. UN ARTICULO PUBLICADO SENALA QUE ESTE TIPO DE MOLECULAS INHIBEN LA PLACA BETA-AMILOIDE, IMPLICADA EN ALZHEIMER. LA IDEA ES QUE EN FUTURO TENGA APLICACIONES TERAPEUTICAS. YA LOGRO LA SEPARACION DE UN NEUROPEPTIDO ACTIVO Y PRONTO EVALUARA PARA VER SU EFICIENCIA, DIJO. EN PROYECTO MULTIDISCIPLINARIO, LA PARTE QUIMICA ESTA A CARGO DEL ENTREVISTADO, Y LA BIOLOGICA, DE CARLOS ROSAS, EXPERTO EN ACUACULTURA DEL OCTOPUS MAYA, QUIEN HA HECHO IDENTIFICACION Y EXTRACCION DE LAS GLANDULAS SALIVALES EN PULPOS ROJOS, TANTO EN CONDICIONES DE LABORATORIO COMO DE PESQUERIA. SAMUEL ESTRADA SOTO RESPONSABLE DEL ASPECTO FARMACOLOGICO. DICHOS TRABAJOS HARAN EN DEPARTAMENTO DE FARMACIA DE LA UNIVERSIDAD AUTONOMA DEL ESTADO DE MORELOS. ADEMAS, INTERVIENEN ESPECIALISTAS EN CONDUCTA DE ANIMALES MARINOS, PRINCIPALMENTE MAITE MASCARO, DE LA UNIDAD MULTIDISCIPLINARIA DE DOCENCIA E INVESTIGACION DE LA UNIVERSIDAD NACIONAL, EN SISAL. PROYECTO, SUBRAYO, HA ABIERTO OTRAS VIAS DE ESTUDIO. EL PAIS TIENE 12 MIL KILOMETROS DE ZONAS COSTERAS Y NO TENEMOS UN GRUPO ESPECIALIZADO EN EXPLORAR SU UTILIDAD COMO FUENTE DE FARMACOS; POR ELLO, EN 'CAMPUS' SISAL COMENZAMOS PRIMER INTENTO, CONCLUYO.
Dose modifications of liposomal irinotecan (nal-IRI) + 5-fluorouracil/leucovorin (5-FU/LV) in NAPOLI-1: Impact on efficacy. (2018)

388 Background: In NAPOLI-1 (NCT01494506), a randomized phase 3 study in patients with metastatic pancreatic cancer previously treated with gemcitabine-based therapy, nal-IRI+5-FU/LV improved overall survival (OS; primary endpoint) vs 5-FU/LV (6.1 mos vs 4.2 mos; HR = 0·67, 95% CI 0.490.92; P = 0.012). This exploratory analysis examined the impact of dose modifications or delays used to manage adverse events (AEs) on OS. The study protocol allowed ≤2 dose reductions for nal-IRI and 5-FU and for up to 3 weeks. Methods: Patient who had a dose delay or reduction within the planned first 6 weeks of the study were included. Delays were defined as any delay in dosing > 3 days from target dosing date and dose reductions were defined as any reduction in dose from initial administered dose. OS was compared within the nal-IRI+5-FU/LV arm and with the 5-FU/LV arm. Comparisons were made using the cohort of 5-FU/LV and nal-IRI+5-FU/LV patients enrolled under protocol version 2. Median OS was based on Kaplan-Meier estimates and Cox regression analysis was used to calculate HRs. Results: More patients in the nal-IRI+5-FU/LV treatment group experienced AEs that required dose delay and/or reduction than in the 5-FU/LV treatment group (62% vs 33%). Within the nal-IRI+5-FU/LV arm, median OS was numerically but not significantly different between patients who did (n = 34) vs did not (n = 83) have a dose reduction (9.3 vs 5.4 mos; HR = 0.66 [95% CI 0.43, 1.01]) and for those who did (n = 49) vs did not (n = 68) have a dose delay (8.4 vs 5.6 mos; 0.82 [95% CI 0.56, 1.23]). Between treatment arms, OS was greater in the nal-IRI+5-FU/LV arm regardless of dose delay or reduction (Table). Conclusions: Dose modifications in the nal-IRI+5-FU/LV arm did not significantly impact OS compared with those who did not need a dose modification, and OS remained greater than in 5-FU/LV-treated patients. This suggests that appropriate dose modification of nal-IRI+5-FU/LV for AEs may not adversely affect outcomes. Clinical trial information: NCT01494506. [Table: see text]
The use of nasal spirometry as an objective measure of nasal septal deviation and the effectiveness of septal surgery (2003)

Nasal spirometry, after decongestion, was used to assess the severity of septal deviation in 31 patients before and after nasal septal surgery. Patients were divided into two groups on the basis of their preoperative nasal partitioning of airflow ratio (NPR). The NPR ranges from 0.00 (equality of airflow) to 1.00 (total unilateral obstruction) with the normal range defined as 0.00-0.34. In 14 patients with a preoperative NPR within the normal range, the median NPR was not influenced by surgery (preop 0.14 to postop 0.12, P= 0.07). In 17 patients with a preoperative NPR outside the normal range, there was a significant reduction of the median NPR after surgery (preop 0.50 to postop 0.16, P < 0.01). The correlation of NPR with subjective assessment of the deviation was r = 0.85 (P < 0.01), and with patient subjective symptom assessment r= 0.94 (P < 0.01) preoperatively and r= 0.51 (P < 0.01) postoperatively. The findings indicate that nasal spirometry may be useful in patient selection for septal surgery.
SPRITE: a computer code for the optimization of space based heat pipe radiator systems (2003)

An integrated analytical tool has been developed for use in designing optimized space-based heat pipe radiator systems. This code, SPRITE-1, incorporates the thermal, structural, and the reliability aspects of the radiator into a single framework from which a physically consistent design can be obtained. A parametric study of the integral heat pipe panel radiator was performed using SPRITE-1, and a preliminary minimum mass design was obtained. The radiator design is summarized, and the mass minimization method and results are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An unusual case of large right atrial myxoma. (1980)

A case of right atrial myxoma is described. The patient had vague and variable symptoms and it was not until five years after first presentation that she had developed clinical and electrocardiographic evidence of right atrial hypertrophy, and angiocardiographic evidence of a fist-sized myxoma which was subsequently removed surgically.
The role of the principal in the student teaching program (1969)

Can a school be improved by the presence of student teachers? It can, says Dr. Briggs, and the principal can make a significant contribution toward this improvement.
The Development of a Deflocculated Polymer Mud for HTHP Drilling (1989)

ABSTRACT A High Solids Deflocculated Polymer (HSDP) drilling fluid has been developed and field proven at densities as great as 2 0.9 ppg (156 pcf) and sustained BHST's above 3 00 degrees Fahrenheit. The approach used to develop the HSDP mud had the primary goal of reducing complexity: a minimum number of additives were incorporated into the mud, and each additive was selected on the basis of its performance and limited functionality. Products with more than one primary function or with a strong secondary function were determined to be unsuitable. The system is composed of a polymer viscosifier, a polymer deflocculant, and a polymer fluid loss agent. Barite is added as needed to develop density, and is the only solid intentionally added to the HSDP system. Viscosity and fluid loss are not developed with clay: this drilling fluid functions best when the MBT is as low as possible. Alkalinity is controlled with sodium hydroxide. The resulting HSDP fluid is manageable at densities exceeding 20 ppg (150 pcf). System rheology is stable at temperatures as high as 350 degrees F. A ten minute gel strength as low as 10 can be maintained if required. The API LTLP filtration rate can be held below 4 cc, and HTHP filtration rate, as defined in this paper, can be kept below 12 cc economically. Field application has demonstrated this mud to be very tolerant to contamination with monovalent and divalent cations (Na+, Mg++, Ca++), carbonates (CO3−−, HCO3−), water, oil, and various gases. It is reasonably tolerant to the presence of drilled solids.
Bayesian Adversarial Learning (2018)

Deep neural networks have been known to be vulnerable to adversarial attacks, raising lots of security concerns in the practical deployment. Popular defensive approaches can be formulated as a (distributionally) robust optimization problem, which minimizes a "point estimate" of worst-case loss derived from either per-datum perturbation or adversary data-generating distribution within certain predefined constraints. This point estimate ignores potential test adversaries that are beyond the pre-defined constraints. The model robustness might deteriorate sharply in the scenario of stronger test adversarial data, fn this work, a novel robust training framework is proposed to alleviate this issue, Bayesian Robust Learning, in which a distribution is put on the adversarial data-generating distribution to account for the uncertainty of the adversarial data-generating process. The uncertainty directly helps to consider the potential adversaries that are stronger than the point estimate in the cases of distributionally robust optimization. The uncertainty of model parameters is also incorporated to accommodate the full Bayesian framework. We design a scalable Markov Chain Monte Carlo sampling strategy to obtain the posterior distribution over model parameters. Various experiments are conducted to verify the superiority of BAL over existing adversarial training methods. The code for BAL is available at h t t p s: / / t i n y u r l . com/yexsaewr.
Use of Erythrocytes Sensitized with Purified Pneumococcal Polysaccharides for the Assay of Antibody and Antibody-producing Cells (1969)

A method was described for the sensitization of erythrocytes with purified type-specific pneumococcal polysaccharide antigens using chromium chloride as a coupling agent. Erythrocytes so sensitized can be used in routine passive hemagglutination and hemolysis tests as well as in the technique of localized hemolysis-in-gel for the detection of specific antibody and specific antibody-producing cells, respectively.
MATCH: An atom‐typing toolset for molecular mechanics force fields (2011)

We introduce a toolset of program libraries collectively titled multipurpose atom-typer for CHARMM (MATCH) for the automated assignment of atom types and force field parameters for molecular mechanics simulation of organic molecules. The toolset includes utilities for the conversion of multiple chemical structure file formats into a molecular graph. A general chemical pattern-matching engine using this graph has been implemented whereby assignment of molecular mechanics atom types, charges, and force field parameters are achieved by comparison against a customizable list of chemical fragments. While initially designed to complement the CHARMM simulation package and force fields by generating the necessary input topology and atom-type data files, MATCH can be expanded to any force field and program, and has core functionality that makes it extendable to other applications such as fragment-based property prediction. In this work, we demonstrate the accurate construction of atomic parameters of molecules within each force field included in CHARMM36 through exhaustive cross validation studies illustrating that bond charge increment rules derived from one force field can be transferred to another. In addition, using leave-one-out substitution it is shown that it is also possible to substitute missing intra and intermolecular parameters with ones included in a force field to complete the parameterization of novel molecules. Finally, to demonstrate the robustness of MATCH and the coverage of chemical space offered by the recent CHARMM general force field (Vanommeslaeghe, et al., J Comput Chem 2010, 31, 671), one million molecules from the PubChem database of small molecules are typed, parameterized, and minimized.
A full bit prefetch DRAM sensing circuit (1996)

A DRAM sensing circuit that achieves both a fast RAS access time and a high-bandwidth burst operation is proposed. For the data burst capability of synchronous DRAM's, 256-bit-long data I/O lines are divided into eight segments. A small local latch is provided for each segment of 32 bit-line pairs to prefetch eight data out of the 256 sense amplifiers. A local buffer is connected to eight local latches through selection switches. Burst read operations, up to eight bits, are done by activating selection switches and the local buffer serially. Besides this prefetch capability, the segmented data I/O line results in very small capacitance, only 0.09 pF. The sensing scheme uses nMOS bit switches and a full Vdd precharge voltage for bit and segmented data I/O lines. Then, after sense amplifiers are turned on, only low-going bit lines are connected to the segmented data I/O lines without any voltage disturbance because of the small capacitance. The proposed circuit, therefore, realizes a high-speed RAS access, which is 16 ns faster than a conventional DRAM. A circuit layout design based on a 0.5-/spl mu/m design rule shows no area impact.
Impact of the Rapid Diagnosis of Influenza on Physician Decision-Making and Patient Management in the Pediatric Emergency Department: Results of a Randomized, Prospective, Controlled Trial (2003)

Physician awareness of a rapid diagnosis of influenza in the pediatric emergency department significantly reduced the number of laboratory tests and radiographs ordered and their associated charges, decreased antibiotic use, increased antiviral use, and decreased length of time to discharge.
Automated Low-Cost and Real-Time Truck Parking Information System (2013)

In this project an automated real-time parking information system was developed to improve truck-parking safety through the efficient gathering and disseminating of information regarding the use of existing parking capacity. The system consists of four main components: sensing, data collection, data processing and user interface (UI). A pilot deployment was conducted on a Maryland State Highway Administration truck parking facility located on Interstate-95 northbound prior to Maryland Route 32. During the testing period of January 6 through 14, 2013, 1,239 events were detected by the system. Each event refers to any truck arrival or departure activity in a spot. The average overall detection error was 3.75 percent and the maximum error was 5 percent. The error rate can potentially be reduced by using more sensors at each spot and using repeaters to avoid signal blockages. Unlike imagery based methods, magnetic truck detection is completely anonymous and thus privacy of drivers is not compromised. It is also independent of parking layout. In addition to providing real-time parking availability information to the truckers, analysis of historical data for each spot and for the parking facility as a whole can reveal dynamics of events and facilitate efficient operations.
Monte Carlo methods in Materials Studio (2013)

We survey the use of the Monte Carlo method within the Materials Studio application, which integrates a large number of modules for molecular simulation. Several of these modules work by generating configurations of a system at random, which can then be used to calculate averages of interest – for instance, interaction energies of contacting pairs of molecules (Blends module) and properties of a flexible polymer chain (Conformers). A different technique is used to sample an appropriate physical distribution (which in practice is that for the canonical ensemble) using the Metropolis or configurational bias method. This is done by the Sorption module (which calculates the thermodynamic properties of small molecules in a matrix) and Amorphous Cell (which constructs periodic simulation cells). Lastly, certain other modules use simulated annealing and related methods to optimise a function, with application to crystal structure prediction from molecular structure (Polymorph Predictor), to crystal structure prediction from X-ray powder diffraction data (Powder Solve) and to find preferential sites for adsorption (Adsorption Locator).
Dancing with the enemy: the interplay of herpes simplex virus with dendritic cells (2005)

Summary Herpes simplex virus (HSV) represents a smart pathogen, which displays both lytic and latent modes of interaction with its natural human host. In order to be optimally equipped for immune evasion and to reply to any attacks of the host during reactivation, HSV has developed a multitude of cleverly devised defence strategies. Dendritic cells (DC) as antigen-presenting cells located at the border zones of the body and the environment have been shown to play a crucial role as one of the first cells interacting with HSV beside epithelial cells, on one hand, and as important controllers of the viral spreading on the other hand. Here, we provide a research update about the interaction of HSV with DC and summarize the latest proceedings in this field.
Problem Solving and Storytelling in Constitutional Law Courses (1998)

The author’s primary methods to teach Constitutional Law are problem solving and storytelling. He selected Farber, Eskridge, and Frickey’s Constitutional Law: Themes for the Constitution's Third Century and continues to use it in part because it includes both stories and problems. The author also selected this particular casebook because it places the individual rights materials before the materials on federal powers. He wanted to experiment with this reversed order and thus far has been satisfied – largely because the rights materials engage student interest better than the powers materials. They also set a more contemporary and practical tone for the course that focuses students on issues they are more likely to confront in practice. In addition, this casebook is more compact than most other constitutional law casebooks and contains more useful background information and other guidance for students. And, as a bottom line, the author believed that the casebook’s approach to the subject would support the type of academically rigorous and challenging course presentation to which he is committed. In general, the author’s experience with the Farber, Eskridge, and Frickey casebook has confirmed all of his initial reasons for selecting it.
The reaction of some alicyclic 1,2-dihalopolyfluoro olefins with ethanolic potassium hydroxide. The effect of ring size on product distribution (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe reaction of some alicyclic 1,2-dihalopolyfluoro olefins with ethanolic potassium hydroxide. The effect of ring size on product distributionJoseph D. Park, Randolph J. McMurtry, and Raymond SullivanCite this: J. Org. Chem. 1968, 33, 1, 33–37Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://pubs.acs.org/doi/10.1021/jo01265a007https://doi.org/10.1021/jo01265a007research-articleACS PublicationsRequest reuse permissionsArticle Views112Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Free surface shape for an ultrasonic nebuliser (2003)

Nebulisers are used for the delivery of fine droplets of drugs to the lungs or smaller bronchii. An ultrasonic nebuliser uses the oscillations caused by a piezoelectric crystal to produce a ``fountain'' in a liquid, which leads to the formation of a mist of fine particles. This work describes a model of an ultrasonic nebuliser, with the aim of demonstrating the mechanism of the fountain formation. It is shown that the oscillating ultrasound causes a mean flow in the liquid due to acoustic streaming, which in turn creates a deformation of the free surface. Cavitation within the liquid, which is an energy intensive process, leads to the dissipation necessary for acoustic streaming to occur. Finally, a mechanism for explaining the location of the mist on the free surface is proposed, based upon the results.
Dynamic Queue Scheduling Using Fuzzy Systems for Internet Routers (2005)

Quality of service (QoS) in the Internet depends on queuing and sophisticated scheduling in routers. In this paper, we address the issue of managing traffic flows with different priorities. In our reference model, incoming packets are first classified based on their priority, placed into different queues with different capacities, and then multiplexed onto one router link. The fuzzy nature of the information on Internet traffic makes this problem particularly suited to fuzzy methodologies. We propose a new solution that employs a fuzzy inference system to dynamically and efficiently schedule these priority queues. The fuzzy rules are derived to minimize the selected Lyapunov function. Simulation experiments show that the proposed fuzzy scheduling algorithm outperforms the popular weighted round Robin (WRR) queue scheduling mechanism