gebhart/patrepeval huggingface dataset:
Solvent Polarity Studies of the Water+t-Butyl Alcohol and Water+t-Butylamine Binary Systems With the Solvatochromic Dyes Nile Red and Pyridinium-N-phenoxide Betaine, Refractometry and Permittivity Measurements (1994)

The empirical solvent polarity parameters ENR and ET for the solvatochromic compounds Nile Red (1) and pyridinium-N-phenoxide betaine (2), respectively, have been determined as a function of composition for water+t -butyl alcohol and water+t-butylamine binary mixtures, over the whole composition range at 298 K. For both systems the two parameters vary with composition in a strongly non-linear fashion, and the polarity of the mixture decreases with increasing proportion of the organic cosolvent. The non-linear variation of the polarity parameters is attributed to water-cosolvent hydrophobic interactions at low cosolvent contents, and hydrogen-bonding interactions at higher cosolvent contents. Permittivity and refractive index have also been measured at 298 K for both systems, and both properties are strongly non-linear functions of composition.
Hyperbolic Functions and Their Properties (2011)

This chapter contains sections titled: Introduction Relation Between Exponential and Trigonometric Functions Similarities and Differences in the Behavior of Hyperbolic and Circular Functions Derivatives of Hyperbolic Functions Curves of Hyperbolic Functions The Indefinite Integral Formulas for Hyperbolic Functions Inverse Hyperbolic Functions Justification for Calling sinh and cosh as Hyperbolic Functions Just as sine and cosine are Called Trigonometric Circular Functions
Ikterische Cholestase als Frühsymptom bei Morbus Hodgkin (2008)

Initial symptoms in a hitherto healthy 23-year-old man were jaundice (bilirubin 21.7 mg/dl) and pruritus, but extensive radiological, endoscopical, microbiological and laboratory investigations failed to reveal the cause. Stool culture positive for Salmonella agona suggested intrahepatic cholestasis resulting from a Salmonella cholangitis. However, antibiotic treatment was not successful. As he was in generally good health the patient declined further investigations. He returned two years later because of fatigue, lack of appetite and weight loss. Further tests now revealed lymphogranulomatosis in stage IVb of the nodular sclerosing type. The case demonstrates that cholestasis as an isolated early symptom of Hodgkin's disease can precede by years any further signs of the disease.
ChemInform Abstract: Metal/Sulfide/Thiolate Chemistry for an Early 3d Transition Metal: Variation of Product Identity as a Function of V:S Reaction Ratio and Structure and Redox Properties of Discrete V/S/edt Complexes. (1988)

Abstract The reactions in the VCl3/elemental S/disodium ethanedithiolate systems in MeCN are described.
The 2008 World Health Organization classification system for myeloproliferative neoplasms (2009)

The first formal classification of chronic myeloid neoplasms is credited to William Dameshek, who in 1951 described the concept of "myeloproliferative disorders (MPD)" by grouping together chronic myelogenous leukemia, polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The 2001 World Health Organization (WHO) classification of myeloid malignancies included these MPDs under the broader category of chronic myeloproliferative diseases (CMPD), which also included chronic neutrophilic leukemia, chronic eosinophilic leukemia/hypereosinophilic syndrome (CEL/HES), and "CMPD, unclassifiable." The revised 2008 WHO classification system featured the following changes: 1) the term "CMPD" was replaced by "myeloproliferative neoplasm (MPN)," 2) mast cell disease was formally included under the category of MPN, and 3) the subcategory of CEL/HES was reorganized into "CEL not otherwise specified (CEL-NOS)" and "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1"; CEL-NOS remained a subcategory of "MPN," whereas the latter neoplasms were now assigned a new category of their own. Furthermore, diagnostic criteria for PV, ET, and PMF were revised by incorporating recently described molecular markers (eg, JAK2 and MPL mutations) as well as underscoring the role of histology in differentiating reactive from clonal myeloproliferations. As a result, red cell mass measurement is no longer necessary for the diagnosis of PV, and ET can now be diagnosed at a lower platelet count threshold. The revised WHO document continues to promote the recognition of histologic categories as a necessary first step toward the genetic characterization of myeloid malignancies.
Investigation of crack initiation with a three color digital holographic interferometer (2012)

This paper proposes a three-color holographic interferometer devoted to the deformation analysis of a composite material submitted to a short beam shear test. The simultaneous recording of three laser wavelengths using a triple CCD sensor results in the evaluation of shear strains at the lateral surface of the sample. Such an evaluation provides a pertinent parameter to detect premature crack in the structure, long before it becomes visible on the real time stress/strain curve, or with a classical microscope.
Modeling dose-response relationships of the effects of fesoterodine in patients with overactive bladder (2010)

The phase III trials used in this analysis have been registered at ClinicalTrials.gov (NCT00220363 and NCT00138723).
Negative-Sequence Current Injection for Fast Islanding Detection of a Distributed Resource Unit (2008)

This paper presents an active islanding detection method for a distributed resource (DR) unit which is coupled to a utility grid through a three-phase voltage-sourced converter (VSC). The method is based on injecting a negative-sequence current through the VSC controller and detecting and quantifying the corresponding negative-sequence voltage at the point of common coupling of the VSC by means of a unified three-phase signal processor (UTSP). UTSP is an enhanced phase-locked loop system which provides high degree of immunity to noise, and thus enable islanding detection based on injecting a small (3%) negative-sequence current. The negative-sequence current is injected by a negative-sequence controller which is adopted as the complementary of the conventional VSC current controller. Based on simulation studies in the PSCAD/EMTDC environment, performance of the islanding detection method under UL1741 anti-islanding test is evaluated, and its sensitivity to noise, grid short-circuit ratio, grid voltage imbalance, and deviations in the UL1741 test parameters are presented. The studies show that based on negative-sequence current injection of about 2% to 3%, islanding can be detected within 60 ms even for the worst case scenario.
The rheological properties of yoghurt with the addition of lyophilized polymerized whey protein. (2009)

The objective of this paper was to investigate the effect of different milk protein preparations and polymerized whey protein addition on rheological properties of stirred yoghurts. Polymerized whey proteins were added in powdered state obtained by freeze-drying. The apparent viscosity, firmness and consistency of the yoghurts were determined. The flow curves were fitted to the power low model. The yoghurts obtained with 2% addtion of double heated whey protein isolate (WPI) exhibited the highest apparent viscosity, i.e. 500 mPa s at the shear rate 50 s -1 . In comparison, the viscosity of yoghurts fortified with whey protein concentrate (WPC) and skim milk powder (SMP) was 118 mPa s and 200 mPa s, respectively. The yoghurts obtained with the polymerized whey protein addition showed homogenous consistency. The utilization of powdered polymerized whey proteins significantly facilitated the process of yoghurt production. These yoghurts exhibited higher viscosity values in comparison to the samples prepared wiht addition of SMP, WPC and WPI.
Semantic context dissemination and service matchmaking in future network management (2011)

SUMMARY The ever‐increasing size, complexity and heterogeneity of telecommunications networks necessitate the introduction of autonomic elements that assist providers in managing and configuring the network's resources. To tackle this increased complexity, it is expected that many specialized autonomic elements will take part in the management process. It becomes necessary for them to collaborate and communicate in order to achieve high‐level, human‐specified, management goals. Therefore, the need for a scalable mechanism to facilitate the interactions between autonomic elements has arisen. This article presents a communications bus, augmented with semantics through the use of ontologies and semantic reasoning, which governs the communication and collaboration between autonomic elements. It supports filtering of context based on meaning. Additionally, it facilitates matchmaking of autonomic element goals with management services using semantic definitions of their inputs, outputs, preconditions and effects. Furthermore, the delay introduced by semantic reasoning was evaluated through an implemented prototype and was shown to be limited to only a few milliseconds. Copyright © 2011 John Wiley & Sons, Ltd.
Direct RF synchronization of a 22 GHz monolithic AlInGaAs quantum well laser with sub-picosecond pulse generation (2012)

A 22 GHz AlInGaAs two-section mode-locked laser is presented here. 860 fs optical pulses with timing jitter of 280 fs (1 Hz-100 MHz) are generated by direct RF modulation of the saturable absorber.
ChemInform Abstract: A Convenient Synthesis of 1,2,3‐Oxadiazol‐5‐ones by the Use of N,N‐ Dimethylchlorosulfitemethaniminium Chloride as Cyclodehydrating Agent. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identification of a Novel Cell Death Receptor Mediating IGFBP-3-induced Anti-tumor Effects in Breast and Prostate Cancer (2010)

Insulin-like growth factor-binding protein-3 (IGFBP-3), a major regulator of endocrine actions of IGFs, is a p53-regulated potent apoptotic factor and is significantly suppressed in a variety of cancers. Recent epidemiologic studies suggest that IGFBP-3 contributes to cancer risk protection in a variety of cancers, and a polymorphic variation of IGFBP-3 influences cancer risk, although other studies vary in their conclusions. Some antiproliferative actions of IGFBP-3 have been reported to be independent of IGFs, but the precise biochemical/molecular mechanisms of IGF-independent, antiproliferative actions of IGFBP-3 are largely unknown. Here we report a new cell death receptor, IGFBP-3R, that is a single-span membrane protein and binds specifically to IGFBP-3 but not other IGFBP species. Expression analysis of IGFBP-3 and IGFBP-3R indicates that the IGFBP-3/IGFBP-3R axis is impaired in breast and prostate cancer. We also provide evidence for anti-tumor effect of IGFBP-3R in vivo using prostate and breast cancer xenografts in athymic nude mice. Further in vitro studies demonstrate that IGFBP-3R mediates IGFBP-3-induced caspase-8-dependent apoptosis in various cancer cells. Knockdown of IGFBP-3R attenuated IGFBP-3-induced caspase activities and apoptosis, whereas overexpression of IGFBP-3R enhanced IGFBP-3 biological effects. IGFBP-3R physically interacts and activates caspase-8, and knockdown of caspase-8 expression or activity inhibited IGFBP-3/IGFBP-3R-induced apoptosis. Here, we propose that IGFBP-3R represents a novel cell death receptor and is essential for the IGFBP-3-induced apoptosis and tumor suppression. Thus, the IGFBP-3/IGFBP-3R axis may provide therapeutic and prognostic value for the treatment of cancer.
Novel 89Zr cell-labeling method for PET imaging of cell trafficking (2015)

519 Objectives With the recent growth of interest in cell-based therapies and radiolabeled cell products, there is a need to develop more sensitive imaging methods for in vivo tracking of living cells. This study describes a novel cell labeling approach with 89Zr (T1/2 =78.4 h) for PET monitoring of stem cell engraftment for myocardial regeneration. Methods A cell labeling agent, 89Zr-desferrioxamine-NCS (89Zr-DBN), was synthesized. Mouse derived melanoma cells (mMCs), dendritic cells (mDCs) and human mesenchymal stem cells (hMSCs) were covalently labeled with 89Zr-DBN via the reaction between the NCS group on 89Zr-DBN and primary -NH2 groups present on cell surface membrane proteins. The stability of the label on the cell was tested by cell efflux studies for 7 days and in in vivo mouse model by serial PET scans and ex vivo biodistribution following intravenous and intramyocardial injections of 89Zr-hMSCs. For comparison, imaging experiments after intravenous injections of 89Zr4+- phosphate were also performed. The effect of labeling on cellular viability was tested by monitoring in vitro cell proliferation, trypan blue and cytotoxicity/apoptosis assays. Results The labeling agent, 89Zr-DBN, was prepared in 55±5% decay-corrected radiochemical yield measured by iTLC. The cell labeling efficiency was 30-50% in 30 min depending on cell type. Radioactivity concentrations of labeled cells of up to 0.5MBq/1x106 cells were achieved after 30 min labeling without a negative effect on cellular viability. No cellular efflux of 89Zr was seen out to 7 d. Myocardially delivered 89Zr-hMSCs showed retention in the myocardium, as well as redistribution to lung and bone, whereas intravenous delivery of 89Zr-hMSCs distributed primarily to lung followed by liver and bone. Free 89Zr4+- phosphate was primarily distributed in bone followed by liver. Thus, the stability of the radiolabel on hMSCs was evidenced. Conclusions We have developed a robust, general, and biostable 89Zr-DBN based cell labeling strategy with promise for wide applications of PET-based non-invasive in vivo cell trafficking. Research Support The work was funded by the Mayo Clinic Department of Radiology.
<title>Intracavity self-adapted photorefractive Fabry-Perot</title> (2001)

Dramatic reduction of the number of oscillating modes in CW and pulsed lasers has been observed using a photorefractive crystal placed inside the cavity. Reflective Bragg gratings recorded by the standing waves inside the crystal act with the output coupler as a self-adapted Fabry-Perot filter. Its spectral characteristics enhance mode competitions which can lead to a single mode operation.
Increased Precursor Cell Proliferation after Deep Brain Stimulation for Parkinson's Disease: A Human Study (2014)

Our data suggest that DBS is capable of increasing cellular plasticity in the brain, and we hypothesize that it may have more widespread effects beyond the electrode location. It is unclear whether these effects of DBS have any symptomatic or other beneficial influences on PD.
Defect reduction of GaAs epitaxy on Si (001) using selective aspect ratio trapping (2007)

Metal-organic chemical vapor deposition growth of GaAs on Si was studied using the selective aspect ratio trapping method. Vertical propagation of threading dislocations generated at the GaAs∕Si interface was suppressed within an initial thin GaAs layer inside SiO2 trenches with aspect ratio &gt;1, leading to defect-free GaAs regions up to 300nm in width. Cross-sectional and plan-view transmission electron microscopies were used to characterize the defect reduction. Material quality was confirmed by room temperature photoluminescence measurements. This approach shows great promise for the fabrication of optoelectronic integrated circuits on Si substrates.
Regulation of cGMP-dependent Protein Kinase Expression by Rho and Krüppel-like Transcription Factor-4 (2006)

Type I cGMP-dependent protein kinase (PKG I) plays a major role in vascular homeostasis by mediating smooth muscle relaxation in response to nitric oxide, but little is known about the regulation of PKG I expression in smooth muscle cells. We found opposing effects of RhoA and Rac1 on cellular PKG I expression: (i) cell density-dependent changes in PKG I expression varied directly with Rac1 activity and inversely with RhoA activity; (ii) RhoA activation by calpeptin suppressed PKG I, whereas RhoA down-regulation by small interfering RNA increased PKG I expression; and (iii) PKG I promoter activity was suppressed in cells expressing active RhoA or Rho-kinase but was enhanced in cells expressing active Rac1 or a dominant negative RhoA. Sp1 consensus sequences in the PKG I promoter were required for Rho regulation and bound nuclear proteins in a cell density-dependent manner, including the Krüppel-like factor 4 (KLF4). KLF4 was identified as a major trans-acting factor at two proximal Sp1 sites; active RhoA suppressed KLF4 DNA binding and trans-activation potential on the PKG I promoter. Experiments with actin-binding agents suggested that RhoA could regulate KLF4 via its ability to induce actin polymerization. Regulation of PKG I expression by RhoA may explain decreased PKG I levels in vascular smooth muscle cells found in some models of hypertension and vascular injury.
Developmental-stage-dependent transcriptional response to leukaemic oncogene expression (2015)

Acute myeloid leukaemia (AML) is characterized by a block in myeloid differentiation the stage of which is dependent on the nature of the transforming oncogene and the developmental stage of the oncogenic hit. This is also true for the t(8;21) translocation that gives rise to the RUNX1-ETO fusion protein and initiates the most common form of human AML. Here we study the differentiation of mouse embryonic stem cells expressing an inducible RUNX1-ETO gene into blood cells as a model, combined with genome-wide analyses of transcription factor binding and gene expression. RUNX1-ETO interferes with both the activating and repressive function of its normal counterpart, RUNX1, at early and late stages of blood cell development. However, the response of the transcriptional network to RUNX1-ETO expression is developmental stage specific, highlighting the molecular mechanisms determining specific target cell expansion after an oncogenic hit.
On the Specific Heat of α Phase Alloys of Iron and Cobalt (1953)

The specific heat of 17 alloys in the range of α solid solution of iron and cobalt system has been measured. It has been found that there are 3 maximum portions on the curve of the maximum temperature of specific heat against concentration, beside the one corresponding to the transformation of FeCo superlattice; the 3 portions extend over the concentration ranges of 20 to 29, 34.6 to 66 and 66 to 78 percent of cobalt, respectively. The maximum portion in the range of 34.6 to 66 percent of cobalt has been already found by S. Kaya and H. Sato and is considered by the present investigators to be due to a lattice transformation of FeCo superlattice. The other maximum portions, in the ranges of 20 to 29 and 66 to 78 percent of cobalt, are considered to be due to the existence of superlattices of Fe3Co and FeCo3, respectively.
Admission Ionized Calcium Levels Predict the Need for Multiple Transfusions: A Prospective Study of 591 Critically Ill Trauma Patients (2011)

Low iCa levels at admission were associated with increased mortality as well as an increased need for both multiple transfusions and massive transfusion. In fact, multivariable logistic regression analysis identified low iCa levels as an independent predictor of multiple transfusions. Admission iCa levels may facilitate the rapid identification of patients requiring massive transfusion, allowing for earlier preparation and administration of appropriate blood products.
Rigorous bounds for optimal dynamical decoupling (2010)

We present rigorous performance bounds for the optimal dynamical decoupling pulse sequence protecting a quantum bit (qubit) against pure dephasing. Our bounds apply under the assumption of instantaneous pulses and of bounded perturbing environment and qubit-environment Hamiltonians such as those realized by baths of nuclear spins in quantum dots. We show that if the total sequence time is fixed the optimal sequence can be used to make the distance between the protected and unperturbed qubit states arbitrarily small in the number of applied pulses. If, on the other hand, the minimum pulse interval is fixed and the total sequence time is allowed to scale with the number of pulses, then longer sequences need not always be advantageous. The rigorous bound may serve as a testbed for approximate treatments of optimal decoupling in bounded models of decoherence.
AVIA - Adaptive virtual aerosurface (2000)

Abstract : One can change the effective shape of a surface without any change in its physical moldlines through the transient injection of momentum to control unsteady flow phenomena, such as separation. This research program consists of a system level evaluation of the potential benefits and costs of active flow control as applied to UAVs for separation control, development of innovative actuator concepts, and proof-of-concept experiments showing aerodynamic effectiveness. System-level benefits include increased gust margin, reduced takeoff field length, increased payload capacity, and greater maneuverability. Actuator research has resulted in two major innovations: the use of pulsed/modulated waveforms to increase the effectiveness of synthetic jet actuators and the development of compact, high power, combustion-driven actuator modules. The general performance of the combustion actuators are characterized in isolation, embedded in cross-flows up to M=0.7, and integrated on a two-dimensional wing model. In addition, since conventional machining would not be suitable for low-cost, large volume production, a simpler, MEMS-based, batch fabrication
The preparation and some properties of 2-methyl-1-propene-1-boronic acid (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe preparation and some properties of 2-methyl-1-propene-1-boronic acidRobert L. Letsinger and Ivan H. SkoogCite this: J. Org. Chem. 1953, 18, 7, 895–897Publication Date (Print):July 1, 1953Publication History Published online1 May 2002Published inissue 1 July 1953https://pubs.acs.org/doi/10.1021/jo50013a019https://doi.org/10.1021/jo50013a019research-articleACS PublicationsRequest reuse permissionsArticle Views446Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prospectively Randomized Evaluation of Stentless Versus Conventional Biological Aortic Valves : Impact on Early Regression of Left Ventricular Hypertrophy (1999)

Regression of left ventricular hypertrophy occurs in all patients after aortic valve replacement but is significantly enhanced after SAV implantation. This possibly is due to improved transvalvular hemodynamics.