gebhart/patrepeval huggingface dataset:
ICAM-1 Contributes to but Is Not Essential for Tumor Antigen Cross-Priming and CD8+ T Cell-Mediated Tumor Rejection In Vivo (2005)

ICAM-1 has been described to provide both adhesion and costimulatory functions during T cell activation. In the setting of antitumor immunity, ICAM-1/LFA-1 interactions could be important at the level of T cell priming by APCs in draining lymph nodes as well as for transendothelial migration and tumor cell recognition at the tumor site. To determine the contribution of ICAM-1 to tumor rejection in vivo, we performed adoptive transfer of 2C TCR-transgenic/RAG2(-/-) T cells into TCRalpha(-/-) vs ICAM(-/-)/TCRalpha(-/-) recipient animals. ICAM-1-deficient mice successfully rejected HTR.C tumors expressing Ld recognized by the 2C TCR, albeit with a kinetic delay. Inasmuch as HTR.C tumor cells themselves express ICAM-1, a second model was pursued using B16-F10 melanoma cells that lack ICAM-1 expression. These cells were transduced to express the SIYRYYGL peptide recognized by the 2C TCR in the context of Kb, which is cross-presented by APCs in H-2b mice in vivo. These tumors also grew more slowly but were eventually rejected by the majority of ICAM-1(-/-)/TCRalpha(-/-) recipients. Delayed rejection in ICAM-1(-/-) mice was associated with diminished T cell priming as assessed by ELISPOT. In contrast, T cell penetration into the tumor was comparable in wild-type and ICAM-1(-/-) hosts, and adoptively transferred primed effector 2C cells rejected normally in ICAM-1(-/-) recipients. Our results suggest that ICAM-1 contributes to but is not absolutely required for CD8+ T cell-mediated tumor rejection in vivo and dominantly acts at the level of priming rather than the effector phase of the antitumor immune response.
The mechanism of sputter-induced orientation change in YBCO films on MgO (001) (1996)

The mechanisms of the sputter-induced orientation change in YBa{sub 2}Cu{sub 3}O{sub 7{minus}x}(YBCO) films grown on MgO (001) substrates by pulsed organometallic beam epitaxy (POMBE) are investigated by x-ray diffraction. Rutherford backscatter spectroscopy (RBS), cross-section TEM (XTEM) and microanalysis. It is found that the W atom implantation concurring with the ion sputtering plays an important role in effecting the orientation change. This implantation changes the surface structure of the substrate and induces an intermediate layer in the initial growth of the YBCO film, which in turn acts as a template that induces the orientation change. It seems that the surface morphology change caused by ion sputtering has only a minor effect on the orientation change.
Insecticidal Dihydropyrazoles with Reduced Lipophilicity (1992)

Dihydropyrazoles are of interest as highly efficacious insecticides that do not show cross resistance with other insecticide classes. However, dihydropyrazoles are highly lipophilic molecules with potential for bioaccumulation. As part of our efforts to discover improved dihydropyrazole insecticides, we focused on modifications that would reduce the lipophilicity of the molecule while retaining the insecticidal activity. This chapter discusses synthesis, biological activity, Quantitative Structure-Activity Relationships, and relevant physical properties of these compounds.
Detailed structural characterization of the organic material in rundle Ramsay Crossing oil shale (1989)

The difficulty of achieving quantitative and selective reactions of insoluble organic solids under mild conditions, and the scarcity of good methods for probing the structures of such materials, have discouraged attempts to characterize the molecular structure of the organic material in solid oil shales. Technical advances in solid state {sup 13}C- and {sup 29}Si-NMR now provide powerful new methods for characterizing hydrocarbon structure and heteroatom functionalities in the solid state. Although questions persist about the quantitative reliability of the cross-polarization NMR technique in coals, compositional effects responsible for non-quantitative data collection are less common in oil shales and in the bitumen and derivatized samples produced from these materials. Using mild and selective derivatizations with isotopically labelled reagents followed by solid state {sup 13}C- and {sup 29}Si-NMR analysis has enabled a comprehensive study to chemically characterize the organic functionalities in Rundle Ramsay Crossing oil shale (RXOS) Queensland, Australia. Combining these data with in-depth MS and NMR analyses on shale oils produced under mild conditions from RXOS led to the development of a detailed structural model of the organic material.
Near-infrared two-dimensional photonic band-gap materials (1996)

We describe the fabrication and optical transmission of two-dimensional periodic dielectric structures with photonic band gaps in the near infrared. The structures consist of triangular arrays of air cylinders embedded in a glass matrix, with center-to-center nearest-neighbor separations between 1.08 and 0.73 μm. The band gaps corresponding to the first Brillouin zone’s boundaries occur at wavelengths between 2.5 and 1.1 μm. For each array size, the band gaps along the two high-symmetry propagation directions are spectrally overlapped for light polarized perpendicular to the cylinder axes. The observed positions, widths, and polarization dependence of the band gaps are in good agreement with theoretical calculations.
Photonic jets produced by microspheres integrated with hollow-core fibers for ultraprecise laser surgery (2013)

Recently it was proposed to use sharply focused optical beams produced by dielectric microspheres, also termed “photonic nanojets”, in contact laser surgery applications. The proposed designs were based on using multimodal beams and suffered from limited efficiency. In this work we developed single-mode designs of such devices providing higher efficiency and significantly smaller focal spot sizes compared to multimodal systems. The proposed single-mode systems include: i) diode-pumped Er:YAG laser source operating at the wavelength corresponding to the maximal water absorption peak in the tissue (λ = 2.94 μm), ii) low-loss hollow-core microstructured fiber delivery, and iii) high-index (n~1.8) focusing barium-titanate glass microsphere integrated with the fiber. By testing the system in air we demonstrated the focal spot diameters to be less than 4λ. Our numerical modeling shows a principal possibility to achieve diffraction-limited spot sizes on the order of λ/2. Due to the fact that the location of the photonic jet at the sphere surface is not strongly affected by the presence of fluid such systems can find applications in ultraprecise contact intraocular, brain or cellular microsurgeries.
Low- and high-temperature superconducting microwave filters (1991)

Stripline and microstrip filters at X-band were designed and fabricated using low- and high-temperature superconductors in quarter-wave, parallel-coupled section configurations. Low-temperature superconducting niobium thin films, deposited on single-crystal sapphire, were used to build to six-pole stripline filters with adjacent passbands and approximately 3 dB crossovers and 1.2% bandwidth. Four- and six-pole microstrip filters were made with in situ epitaxial YBa/sub 2/Cu/sub 3/O/sub 7/ (YBCO) films on LaAlO/sub 3/ substrates. All the YBCO filters showed 77 K passbands with clean skirts and high out-of-band rejection. The six-pole filters had adjacent passbands with -28 dB crossovers and 1.5% bandwidth.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Direct modulation laser technology toward 50-GHz bandwidth (2016)

A short cavity distributed reflector (DR) laser with a modulation bandwidth of 55GHz was developed using the photon-photon resonance and detuned-loading effects. The importance of the chirp parameter for the speed enhancement is discussed.
ETEC colonization factors modulate the antigen presentation function of porcine intestinal mononuclear phagocytes (2013)

Enterotoxigenic E. coli (ETEC) are still a major cause of traveller's diarrhea and intestinal infections in children in less affluent countries.In addition, ETEC infections lead to postweaning diarrhea in piglets and result in significant economic losses in swine production.This intestinal pathogen displays colonization factors or fimbriae on its surface enabling the colonization of the small intestinal epithelia.In swine, F4 and F18 fimbriae are frequently associated with ETEC--induced diarrhea.As opposed to F4 fimbriae, oral immunisation with F18 fimbriae fails to protect animals from a challenge infection.Besides structural differences and a different uptake mechanism by the intestinal epithelium of F18 (M--cell dependent transport) and F4 fimbriae (M--cell and enterocyt--dependent transport), these fimbriae could differently modulate the function of intestinal phagocytes.Indeed, F18 fimbriae drastically diminished the antigen presentation capacity of mononuclear phagocytes (MHCII + SIRP hi ) isolated from the small intestinal lamina propria.As F18 fimbriae bind glycosphingolipids and presumably disrupt lipid raft formation, the impaired antigen presentation ability of the intestinal phagocytes could result from a F18 fimbriae--mediated deformation of the immunological synapse.These results could accelerate the development of an improved F18 + ETEC vaccine and hint at novel immune evasive mechanisms employed by bacterial pathogens.
A comparative study on the heparin‐binding proteomes of <i>Toxoplasma gondii</i> and <i>Plasmodium falciparum</i> (2014)

Toxoplasma gondii is an obligatory intracellular apicomplexan parasite which exploits host cell surface components in cell invasion and intracellular parasitization. Sulfated glycans such as heparin and heparan sulfate have been reported to inhibit cell invasion by T. gondii and other apicomplexan parasites such as Plasmodium falciparum. The aim of this study was to investigate the heparin-binding proteome of T. gondii. The parasite-derived components were affinity-purified on the heparin moiety followed by MS fingerprinting of the proteins. The heparin-binding proteins of T. gondii and P. falciparum were compared based on functionality and affinity to heparin. Among the proteins identified, the invasion-related parasite ligands derived from tachyzoite/merozoite surface and the secretory organelles were prominent. However, the profiles of the proteins were different in terms of affinity to heparin. In T. gondii, the proteins with highest affinity to heparin were the intracellular components with functions of parasite development contrasted to that of P. falciparum, of which the rhoptry-derived proteins were prominently identified. The profiling of the heparin-binding proteins of the two apicomplexan parasites not only explained the mechanism of heparin-mediated host cell invasion inhibition, but also, to a certain extent, revealed that the action of heparin on the parasite extended after endocytosis.
Adrenomedullin Regenerates Alveoli and Vasculature in Elastase-induced Pulmonary Emphysema in Mice (2005)

Adrenomedullin improved elastase-induced emphysema at least in part through mobilization of bone marrow cells and the direct protective effects on alveolar epithelial cells and endothelial cells.
<i>In situ</i> SFG spectroscopy of film growth. I. General formulation and the analysis of the signal observed during the deposition of formic acid on Pt(110)-(1×2) surface (1998)

The application of infrared-visible sum-frequency generation (SFG) spectroscopy to the in situ monitoring of film growth was examined by the observation of the growth of the physisorbed layer of formic acid on a reconstructed Pt(110)-(1×2) surface. The signal by the CH stretching band displayed a characteristic interference pattern as deposition proceeded at 158 K to prove that the signal originated from inside the deposited film and the CH bond and molecular plane of formic acid was angled to the surface. The expressions for the electric fields of the SF beams generated inside the film, at the top layer, and at the bottom layer were derived by incorporating the interference effects of the exciting and generated light beams. The formula was used to simulate the observation and to estimate the growth rate.
Growth of enterotoxigenic Staphylococcus aureus in povi masima, a traditional Pacific island food (2004)

Under conditions traditionally used to cure and store this food, enterotoxigenic staphylococci can grow to numbers where toxigenesis might occur, especially during the early stages of curing where the salt has not diffused from the brine into the meat.
Disagreement between ultrasound and magnetic resonance imaging in the identification of schistosomal periportal fibrosis (2006)

Abdominal ultrasound (US) has been widely used in the evaluation of patients with schistosomiasis mansoni. It represents an important indirect method of diagnosis and classification of the disease, and it has also been used as a tool in the evaluation of therapeutic response and regression of fibrosis. We describe the case of a man in whom US showed solid evidence of schistosomal periportal fibrosis and magnetic resonance imaging revealed that periportal signal alteration corresponded to adipose tissue which entered the liver together with the portal vein.
Stochastic Combinatorial Optimization under Probabilistic Constraints (2008)

In this paper, we present approximation algorithms for combinatorial optimization problems under probabilistic constraints. Specifically, we focus on stochastic variants of two important combinatorial optimization problems: the k-center problem and the set cover problem, with uncertainty characterized by a probability distribution over set of points or elements to be covered. We consider these problems under adaptive and non-adaptive settings, and present efficient approximation algorithms for the case when underlying distribution is a product distribution. In contrast to the expected cost model prevalent in stochastic optimization literature, our problem definitions support restrictions on the probability distributions of the total costs, via incorporating constraints that bound the probability with which the incurred costs may exceed a given threshold.
Increasing the hydrophobic interaction between terminal W-motifs enhances the stability of Salmonella typhimurium sialidase. A general strategy for the stabilization of β-propeller protein fold (2001)

Protein engineering of the beta-propeller protein aimed at enhancing the structural stability of the protein was carried out using a monomeric single domain beta-propeller protein, Salmonella typhimurium sialidase, as a model. Ala53 and Ala69 each located at strands B and C of the W1 motif were mutated to Leu and Val, respectively, to increase the hydrophobic interaction between W1 and W6 motifs. The mutants showed enhanced stability towards guanidine hydrochloride and thermal unfolding. Ala53Leu showed higher stability, probably owing to the capability of the mutated Leu to interact extensively with more residues involved in the hydrophobic interactions between the terminal W-motifs. The mutations, which are located far from the active site, have no significant effect on the enzymatic properties. The strategy to enhance the stability proposed here might be applied to the other beta-propeller proteins.
The Effect of Thermal Annealings of PZT Thin Films Prepared by Sol-Gel (2002)

Properties of Pb(Zr 0.52 Ti 0.48 )O 3 ferroelectric thin films prepared by rapid thermal annealing(RTA)/direct insertion thermal annealing(DITA) were investigated. The morphologies and ferroelectric properties are affected strongly by thermal treatment. The remnant polarization(Pr), and coercive force(Ec) of typical sample are about 13.7 w C/cm 2 and 55.6 kV/cm, respectively. The dielectric constant and loss tangent are 786 and 2.4 % at 100 Hz respectively. The PZT film prepared by RTA and dried at 350 °C possesses desirable ferroelectric and insulation properties, which is applicable to FRAM or piezoelectric MEMS.
MONITORING, CONTROL AND MANAGEMENT ON THE MOTORWAY NETWORK IN HESSEN USING INTELLIGENT TRAFFIC MODELLING (1997)

The Federal Land of Hessen (Germany) is probably a region with one of the densest motorway networks in Europe. Consequently, many control systems have already been connected to the Traffic Control Center (TCC) at Russelsheim. Caused by the increasing traffic demand, it has become necessary to extend the TCC by intelligent tools for monitoring, control and management. For that goal the Hessen road authority has started a big software development project aiming in the extension of the TCC by intelligent tools. So new software will be implemented for data completion (plausibility check, data completion, traffic flow analysis), prediction (pattern prediction, estimation of delay time in case of congestion, self-learning travel speed prediction), traffic analysis (traffic state classification, incident analysis and traffic situation analysis) and network control/coordination and management (alternative route guidance, generation of warning messages, coordination of overlapping control systems, network management). The first phases of the project including all specifications, the data completion sub-system as well as the traffic analysis sub-system are already in the implementation phase. The whole TCC-extension will be operable by the end of the running year. For the covering abstract, see IRRD 490001.
Synthesis of Polymer Particles in Microfluidic Reactors (2011)

This chapter contains sections titled: Introduction Particles Synthesized by Free-Radical Polymerization Polymer Particles Synthesized by Polycondensation Combination of Free-Radical Polymerization and Polycondensation Reactions General Considerations on the Use of Other Polymerization Mechanisms Important Aspects of Microfluidic Polymerization of Polymer Particles Synthesis of Composite Particles References
Wideband Macromodels in Finite Element Method (2015)

This letter proposes a novel projection technique for accelerating Finite Element Method simulations. The algorithm is based on the Second-order Arnoldi Method for Passive Order Reduction (SAPOR). It involves generation of two projection bases and thanks to this it is applicable to the systems of equations, which contain the quadratic frequency-dependence in the input term, that arise when projection is applied locally in the selected subregions of the computational domain. Numerical experiments show, that the proposed approach can be used to generate local macromodels, which are reliable for the wide frequency band simulations.
New Insights on the Mechanism of the NO Reduction with CO over Alumina-Supported Copper Catalysts (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Insights on the Mechanism of the NO Reduction with CO over Alumina-Supported Copper CatalystsM. Fernandez-Garcia, C. Marquez Alvarez, I. Rodriguez-Ramos, A. Guerrero-Ruiz, and G. L. HallerCite this: J. Phys. Chem. 1995, 99, 44, 16380–16382Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/j100044a027https://doi.org/10.1021/j100044a027research-articleACS PublicationsRequest reuse permissionsArticle Views194Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Sorting with optical compare-and-exchange modules (1988)

Sorting is central to the solution of many knowledge-based and switching problems in advanced computation and communication systems. Parallel-pipelined sorting algorithms are appropriate for applications that demand high throughput, low delay, and many data channels. One such algorithm, the bitonic sort, can be implemented with passive perfect shuffle interconnects between active stages of compare-and-exchange (C&E) elements. In this paper we focus on optical hardware to implement the C&E operation and show that, by taking advantage of a distinctive feature of optical logic, namely, bistability, comparison circuits of remarkable simplicity are attainable. We describe implementations of C&E in a variety of optical device technologies capable of performing latching and nonlatching logic. Based on the device characteristics we outline potential application areas for each technology.
Anaerobic Degradation of Naphthalene and Pyrene by Sulfate-Reducing Cultures Enriched from Former Manufactured Gas Plant Soil (2022)

Biodegradation of polycyclic aromatic hydrocarbons (PAHs) under completely anaerobic sulfate-reducing conditions is an energetically challenging process. To date, anaerobic degradations of only two-ringed naphthalene and three-ringed phenanthrene by sediment-free and enriched sulfate-reducing bacteria have been reported. In this study, sulfate-reducing enrichment cultures capable of degrading naphthalene and four-ringed PAH, pyrene, were enriched from a contaminated former gas plant site soil. Bacterial community composition analysis revealed that a naphthalene-degrading enrichment culture, MMNap, was dominated (84.90%) by a Gram-positive endospore-forming member of the genus Desulfotomaculum with minor contribution (8.60%) from a member of Clostridium. The pyrene-degrading enrichment, MMPyr, was dominated (97.40%) by a species of Desulfotomaculum. The sequences representing the Desulfotomaculum phylotypes shared 98.80% similarity to each other. After 150 days of incubation, MMNap degraded 195 µM naphthalene with simultaneous reduction of sulfate and accumulation of sulfide. Similarly, MMPyr degraded 114 µM pyrene during 180 days of incubation with nearly stochiometric sulfate consumption and sulfide accumulation. In both cases, the addition of sulfate reduction inhibitor, molybdate (20 mM), resulted in complete cessation of the substrate utilization and sulfate reduction that clearly indicated the major role of the sulfate-reducing Desulfotomaculum in biodegradation of the two PAHs. This study is the first report on anaerobic pyrene degradation by a matrix-free, strictly anaerobic, and sulfate-reducing enrichment culture.
Studies on Seven-Membered Ring Derivatives. II (1952)

Particulars obtained for 3-oximino-4-oxohomocamphor, m. p. 112°, described in the previous report, are as follows:1) Besides forming colored complex salts with potassium and ferrous ions, it also forms colored salts with other metallic ions.2) It gives camphoric acid and camphoric anhydride in a good yield with reagents that induces the Beckmann rearrangement. It was also confirmed that, in the case of conc. sulfuric acid, carbon monoxide is generated at the same time, so that its reaction mechanism must belong to the second type Beckmann rearrangement, and the formation of camphoric acid monocyanide (VIII) as an unstable intermediate, was assumed.3) Of the two possible structures of (Va) and (Vb), (Va) was assumed to be more appropriate for 3-oximino-4-oxohomocamphor.
The Young Community of the European Association of Preventive Cardiology: The future in motion (2018)

No abstract available