gebhart/patrepeval huggingface dataset:
The Effect of Manganese Additions on Properties of New Magnet Alloy &ldquo;Malcolloy&rdquo; in the System of Cobalt and Aluminium (1968)

Since the discovery of new magnet alloy “Malcolloy” having a high coercive force in the system of cobalt and aluminium, the present investigators have continued researches on the effect of additions of nickel, molybdenum, titanium, vanadium, chromium and tungsten on the properties of Malcolloy ; the highest coercive force obtained with each alloy is 1450 to 1600 Oe. In this report the effect of manganese addition on the properties of Co–Al alloys was examined, with the results that the coercive force of the alloys decreases and the residual flux density increases gradually with increasing manganese content: The maximum energy product shows the highest value in the alloy containing 84.59% Co, 12.81% Al and 2.60% Mn which exhibits a maximum energy product of 2.50×106 G·Oe, a residual flux density of 5900 G, and a coercive force of 860 Oe, when tempered at 525°C for 20 hours after water-quenching from 1375°C. These alloys consist of many ferromagnetic elongated particles about 350 Å in mean diameter which are dispersed in the matrix of the nearly nonmagnetic β′ phase. Consequently, it is considered that the high coercivity of the alloy is mainly due to the presence of the fine particles of a single magnetic domain.
Transferrin can replace serum for <i>in vitro</i> growth of mitogen‐stimulated T lymphocytes (1979)

Activation of human T cells by mitogens was compared in cultures containing serum, human serum albumin or purified human transferrin as growth support. The mitogenic effect of the lectins leucoagglutinin, concanavalin A and Wistaria floribunda agglutinin was measured as incorporation of [3H]thymidine into the cellular DNA of the lymphocytes. Three different preparations of transferrin were all able to fully substitute serum or serum albumin as growth promotors, when present at concentrations of 10 microgram/ml or more. A small contamination of transferrin in the human serum albumin preparations used was shown to be responsible for their growth-supporting effect, while no need for the presence of albumin itself could be demonstrated.
The properties of adenosine triphosphatase from exponential and synchronous cultures of <i>Alcaligenes eutrophus</i> H16 (1978)

The properties of Alcaligenes eutrophus ATPase (adenosine triphosphatase) were investigated by using subcellular fractions prepared from cells growing in exponential and synchronous cultures. Both the soluble and membrane-bound forms of the ATPase were inhibited non-competitively (K(i) 142mum) by Nbf-Cl (4-chloro-7-nitrobenzofurazan), whereas only the membrane-bound enzyme was inhibited (non-competitive; K(i) 750mum) by NN'-dicyclohexylcarbodi-imide. Neither the activity of the ATPase nor its sensitivity to these two inhibitors varied during exponential growth. However, marked variations in ATPase activity were observed during synchronous growth, which were characterized by maxima at approx. 0.4 and 0.9 of a cell cycle and minima at approx. 0.1 and 0.6 of a cycle. Sensitivity to Nbf-Cl and NN'-dicyclohexylcarbodi-imide also varied during the cell cycle; maximum inhibition by the former occurred at approx. 0.4 and 0.9 of a cell cycle, whereas maximum inhibition by the latter was located at approx. 0.1 and 0.6 of a cell cycle. Proton conductance by whole cells was also periodic during the cell cycle, the lowest rates occurring at approx. 0.15 and 0.55 of a cycle and the highest rates at approx. 0.4 and 0.9 of a cycle, but -->H(+)/O quotients for the oxidation of endogenous substrates remained relatively constant and indicated the presence of four proton-translocating respiratory segments throughout the cell cycle. These results are discussed in terms of ATPase and respiratory-chain structure and function during the cell cycle of Alcaligenes eutrophus.
Simplified Procedures for Designing Adhesively Bonded Composite Joints (1991)

Procedures for the preliminary design of composite adhesive joints are described. Typical joints, their respective free body diagrams and approximate equations for estimating the stresses in each of these typical joints are summarized. Equations are also presented to check the critical conditions of the joint, such as: minimum length, max imum adhesive shear stress and peel-off stress. To illustrate the procedure, sample designs are described in step-by-step fashion for a butt joint with single doubler subjected to static loads, cyclic loads and environmental effects. The results show that (1) unsymmetric adhe sive joints are inefficient and should be avoided, and (2) hygrothermal environments and cyclic loads dramatically reduce the structural integrity of the joint and require several joint lengths compared to those for static load with no environmental effects.
Angle Accuracy of Antenna Noise Corrupted Ultra-Wideband Monopulse Receiver (2007)

In the ultra-wideband monopulse receiver, the incident signal is received with two receiving antennas in sum and difference mode. The received signals' phase and energy are then compared to find the incident signal. The received signals, however, are susceptible to antenna noise. In this paper, we establish the relationship between the angle accuracy of the proposed receiver and the signal-to-noise ratio. The receiver modeled in this paper consists of two co-located ridged-horns, with their sum/difference signals received by cross-correlation receivers and processed by an ideal amplitude-comparison monopulse processor. The derived angle accuracy is compared with monopulse measurements at angles -5deg to +5deg at 1deg intervals. Measurements verify the derivations, showing a root-mean-square error of 0.43deg (measured) vs. 0.46deg (theoretical) at boresight; 0.13deg (measured) vs. 0.09deg (theoretical) at -5deg; and 0.17deg (measured) vs. 0.09deg (theoretical) at +5deg.
Vibrio cholerae, Vibrio parahaemolyticus, and Other Vibrios: Occurrence and Distribution in Chesapeake Bay (1977)

Vibrio cholerae was isolated at several locations in Chesapeake Bay in fall 1976 and spring 1977. Strains induced fluid accumulation in rabbit ileal loops and positive activity in Y-1 adrenal cells. Vibrio cholerae, Vibrio parahaemolyticus, and related vibrios show a spatial and temporal distribution characteristic of Vibrio species in an estuary. The Vibrio cholerae strains isolated from Chesapeake Bay represent serotypes other than O-group I--that is, so-called nonagglutinable vibrios--and are not recognized as a serious epidemic threat, although they have caused cholera-like diarrhea sporadically.
Abrupt Phosphorus Profiles in Si (2003)

The effect of growth temperature and substitutional carbon on phosphorus autodoping in Si grown by low pressure rapid thermal chemical vapor deposition was investigated. In the temperature range between 550 and 700°C, phosphorus autodoping decreased with decreasing temperature. The incorporation of substitutional carbon at 550°C further suppressed autodoping. Using a combination of 550°C growth and substitutional carbon incorporation, we achieved abrupt phosphorus transitions over three decades of phosphorus concentration. These transitions were characterized by a slope of © 2003 The Electrochemical Society. All rights reserved.
New Products (2018)

In order to supplement manufacturers’ information, this Department will welcome the submission by our readers of brief communications reporting measurements on the physical properties of materials which supersede earlier data or suggest new research applications.
Targeting an embryonic signaling pathway to suppress the metastatic phenotype (2010)

Abstract The diagnosis of melanoma is becoming more frequent. Although surgical excision of early lesions is associated with relatively significant high cure rates, treatment modalities are largely unsuccessful for advanced disease. Characteristics such as cellular heterogeneity, phenotypic plasticity and the expression of embryonic related molecules and signaling pathways that are important for self renewal and pluripotency, present a challenge in targeting the most aggressive tumor cells. However, the absence of major regulatory checkpoints in these tumor cells allows aberrant activation of embryonic signaling pathways. In particular, the embryonic morphogen Nodal, belonging to the TGF-β superfamily, is an important regulator of embryonic stem cell fate. We have recently demonstrated that Nodal is also expressed in aggressive melanoma, although unlike embryonic stem cells, melanoma does not express Lefty, a natural inhibitor of Nodal, thus allowing Nodal to be expressed in an unregulated manner. Further analysis revealed that Lefty is silenced in these tumor cells by DNA methylation. Down-regulation of Nodal expression in melanoma cells results in a significant reduction in clonogenicity and suppression of tumorigenesis. Additional translational studies indicate that antibodies against Nodal are capable of targeting and inducing apoptosis in human melanoma tumors lodged in the lungs of nude mice. Furthermore, our data show another stem cell signaling pathway, Notch, is expressed in these aggressive melanoma cells, and there is direct evidence demonstrating the molecular cross-talk between Nodal and Notch. Thus, these two prominent stem cell pathways contributing to melanoma cell plasticity may serve as promising dual therapeutic targets for clinical intervention.
Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 2: new immune paradigm. (2013)

Alzheimer's disease (AD) is the most common form of dementia. Its most important pathological hallmarks are profound neuronal loss, presence of intracellular neurofibrillary tangles, and extracellular deposition of beta-amyloid protein (Aβ) as beta-amyloid plaques. One of the most important risk factors for AD is age and with the increase of life-expectancy AD has become the most common form of dementia. The current "Holy Grail" is to be able to diagnose variants of AD before they manifest clinically and before irreparable brain damage is done. To be able to do so, we need robust and reliable biomarkers which reflect the pathogenesis of AD. This is essential because such biomarkers might indicate pathways that could be targeted for interventions aiming at disease prevention or amelioration. Although much attention has been focused on Aβ in this respect, it may not be as attractive a target as thought if current doubts concerning its causative role are substantiated. This review will be in two parts, the first part dealt with the current clinical knowledge and the questions raised by the Aβ cascade hypothesis in the pathogenesis of AD and this second part aims to synthesize our current knowledge and new data suggesting how immunity may contribute to the development of AD and may itself be targeted in future treatments.
Radiation Hazard from Americium‐Beryllium Neutron Moisture Probes (1976)

Abstract Neutron fluxes from shielded neutron moisture probes need to be measured to evaluate total radiation exposure from these instruments. Theoretical considerations suggest that for 100 mCi Am‐Be neutron moisture probes the fast neutron flux can be relatively high and contribute significantly to the radiation exposure of probe operators. Measured radiation dose levels at the surface of 100 mCl Am‐Be neutron probes manufactured by Troxler Laboratories were found to be as high as 37m Rem hours ‐1 which exceeds reported levels by as much as 38 times. This is likely due to nonreporting of fast neutron fluxes. Conventional field use of these probes may present a radiation hazard to operators if the probe is hand carried for periods which exceed 3 hours/week. The probe should be transported to and from sites inside a wooden storage crate and be kept at least 1 m from personnel. To improve the radiation safety factor for on site use we recommend a hand cart to transport the probe.
Intrinsic Size Effects in a Barium Titanate Glass‐Ceramic (1998)

A series of glass ceramics have been synthesized to produce bulk materials with nanometer‐sized barium titanate (BaTiO 3 ) crystals grown in a residue glass matrix. Structure‐property relations have been made to determine the size distribution and the dielectric temperature dependence of the ceramics. Through dielectric and density mixing laws, it has been inferred that depolarization fields limit the dielectric polarizability of the particles and influence the transition temperature. The transition temperature, dielectric anomaly broadening, and peak dielectric constant all scale systematically with the mean size of the BaTiO 3 crystals, which is consistent with an intrinsic size effect. In addition, scaling the transition temperature with the Ishikawa relation predicts a critical size of 17 nm, for which BaTiO 3 cannot support a ferroelectric transition. These results are discussed in relation to other size studies on ferroelectric materials.
Differential Bone Loss in Mouse Models of Colon Cancer Cachexia (2017)

Cachexia is a distinctive feature of colorectal cancer associated with body weight loss and progressive muscle wasting. Several mechanisms responsible for muscle and fat wasting have been identified, however it is not known whether the physiologic and molecular crosstalk between muscle and bone tissue may also contribute to the cachectic phenotype in cancer patients. The purpose of this study was to clarify whether tumor growth associates with bone loss using several experimental models of colorectal cancer cachexia, namely C26, HT-29, and Apc<sup>Min/+</sup>. The effects of cachexia on bone structure and strength were evaluated with dual energy X-ray absorptiometry (DXA), micro computed tomography (μCT), and three-point bending test. We found that all models showed tumor growth consistent with severe cachexia. While muscle wasting in C26 hosts was accompanied by moderate bone depletion, no loss of bone strength was observed. However, HT-29 tumor bearing mice showed bone abnormalities including significant reductions in whole-body bone mineral density (BMD), bone mineral content (BMC), femoral trabecular bone volume fraction (BV/TV), trabecular number (Tb.N), and trabecular thickness (Tb.Th), but no declines in strength. Similarly, cachexia in the Apc<sup>Min/+</sup> mice was associated with significant decreases in BMD, BMC, BV/TV, Tb.N, and Tb.Th as well as decreased strength. Our data suggest that colorectal cancer is associated with muscle wasting and may be accompanied by bone loss dependent upon tumor type, burden, stage and duration of the disease. It is clear that preserving muscle mass promotes survival in cancer cachexia. Future studies will determine whether strategies aimed at preventing bone loss can also improve outcomes and survival in colorectal cancer cachexia.
Flow-induced vibration -- 1996. PVP-Volume 328 (1995)

The relationship between metabolic disorders and the distribution of fat in different body regions is not clearly understood in humans. The aim of this study was to develop a suitable method for assessing the regional distribution of fat deposits and their metabolic effects in dogs. Twenty-five dogs were subjected to computed tomographic (CT) imaging and blood sampling in order to characterise their metabolic status. The different fat areas were measured on a cross-sectional scan, and the animals' metabolic status was evaluated by measuring fasting glucose, insulin and leptin levels. The volume of visceral adipose tissue is the main determinant of leptin levels. The correlation of visceral fat volume and leptin concentration was found to be independent of insulin levels or the degree of insulin resistance. There was a positive correlation between the visceral to subcutaneous fat volume ratio and serum insulin concentration, and a similar trend was observed in the relationship of fat ratio and insulin resistance. The distribution of body fat essentially influences the metabolic parameters in dogs, but the effects of adiposity differ between humans and dogs. The findings can facilitate a possible extrapolation of results from animal studies to humans with regard to the metabolic consequences of different obesity types.
Right Ventricular Response to Aortic Unclamping During Aneurysmectomy (1999)

To the Editor: Ueda et al.'s [1] concise demonstration of increased right ventricular (RV) afterload after aortic unclamping (AU) during abdominal aortic aneurysmectomy (AAA) focuses attention on an important phenomenon, particularly when a when a rapid infusion system (RIS[registered sign]; Haemonetics, Braintree, MD) is used to correct hypovolemia. The rapid increase in preload produced by the RIS[registered sign] may predispose patients to RV failure after AU. This is illustrated in a study recently conducted in 10 patients undergoing thoraco-AAA [2]. Approximately 5 min after AU, mean pulmonary arterial pressure increased 9.8 +/- 2.3 mm Hg, pulmonary vascular resistance increased 63.2 +/- 14.4 dyne.s.cm-5, whereas RV stroke work index increased 4.5 +/- 0.88 g [middle dot] m-1 [middle dot] m-2. The etiology of this phenomenon is multifactorial. Ueda et al. [1] performed blood gas analyses in their study but did not report any specific data. In our study [2], blood gas analysis revealed a decreased pH (0.2 +/- 0.4), decreased base excess (5.9 +/- 1.7 mmol/L), and increased PaCO2 (19.4 +/- 4.2 mm Hg) after AU, which suggests that combined metabolic and respiratory acidosis are contributory physiologic mechanisms. Unfortunately, Ueda et al. [1] do not provide any practical clinical solutions to ameliorating this phenomenon after AU, such as using a pharmacological buffer that does not generate CO2 (tromethamine) or the temporary application of a selective pulmonary vasodilator (nitric oxide). Paul G. Loubser, MD Baylor Anesthesiology; Houston, TX 77030
Photon trains and lasing: The periodically pumped quantum dot (1998)

We propose to pump semiconductor quantum dots with surface acoustic waves that deliver an alternating periodic sequence of electrons and holes. In combination with a good optical cavity such regular pumping could entail antibunching and sub-Poissonian photon statistics. In the bad-cavity limit a train of equally spaced photons would arise.
Active-device capacitances (1971)

The charge-control capacitance ∂Q/∂V looking into a device port is not in general equal to the intrinsic small-signal capacitance found from the low-frequency admittance ratios up to 7:1 occur in practice. This paper explains why the discrepancy occurs, and derives the condition for the discrepancy to be zero. Finally, it is shown that charge-control theory does correctly predict the gain-bandwidth product of an active device.
Separation of Oxidative from Phosphorylative Activity by Proteolysis of Glyceraldehyde-3-Phosphate Dehydrogenase<sup>*</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeparation of Oxidative from Phosphorylative Activity by Proteolysis of Glyceraldehyde-3-Phosphate Dehydrogenase*I. Krimsky and E. RackerCite this: Biochemistry 1963, 2, 3, 512–518Publication Date (Print):May 1, 1963Publication History Published online1 May 2002Published inissue 1 May 1963https://pubs.acs.org/doi/10.1021/bi00903a021https://doi.org/10.1021/bi00903a021research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A factor shed by lymphoblastoid cell lines of HLA-B27 positive patients with ankylosing spondylitis, specifically modifies the cells of HLA-B27 positive normal individuals. (1983)

Epstein-Barr virus transformed lymphoblastoid cell lines from HLA-B27 positive individuals with ankylosing spondylitis (B27+AS+) release, into the culture medium, a factor capable of specifically modifying the HLA-B27 positive lymphocytes of normal individuals (B27+AS-); this modification results in a phenotypic change similar to that seen on B27+AS+ lymphocytes. This lymphoblastoid cell line derived factor appears to be physically and functionally similar to a factor present in the culture filtrate of certain Klebsiella isolates. Biogel P-100 chromatography of the material released from the cell line indicated a mol.wt of 25,000-30,000, similar to that of the Klebsiella derived factor. Chromatofocusing on a PBE 94 column revealed that cell line derived factor had an isoelectric point of 5.5 (cf. pI 5.4 for the Klebsiella derived factor). Immunoadsorption experiments suggest that the factor from the B27+AS+ cell line shares antigenic determinants with a cell surface component present on certain Klebsiella isolates. These results will form the basis for future studies on the nature of the interaction between HLA-B27 and certain enteric organisms and their products. A better understanding of this association should elucidate some of the early events in the pathogenesis of the seronegative arthropathies.
Designing IBC cells with FFE: Long range effects with circuit simulation (2016)

IBC cells with Front Floating Emitter (FFE) pose different design challenges compared to more conventional IBC cells with FSF (Front Surface Field). The FFE enables hole transport over distances that are large compared to the typical BSF or emitter width. The core of the cell design is commonly a device simulation in which, because of the computer resources involved, typically one simulates an as small as possible, but representative part of the solar cell. In an IBC cell this corresponds to 1/2 of the BSF and 1/2 of the emitter. Such a unit cell does not account for important geometric features, such as busbars and pads, edges or interruptions in metallization fingers. We show how to construct an equivalent circuit for our Mercury FFE IBC cells to model features beyond the unit cell efficiently, taking into account the lateral hole transport in the FFE. We compare and calibrate the circuit model against device simulations with quokka.