gebhart/patrepeval huggingface dataset:
Variation in gene expression profiles of peripheral blood mononuclear cells from healthy volunteers (2005)

The normal degree of intra- and interindividual variation in gene transcription profiles of healthy human tissues has not been extensively investigated. In the study described here, microarrays were employed to analyze gene transcription in peripheral blood mononuclear cells prepared from serial blood samples that had been obtained, at weekly intervals, from apparently healthy human volunteers. Transcript levels for the majority of genes examined were found to be remarkably consistent within samples from a single donor. Conversely, marked differences were observed in samples obtained from different donors. Genes that exhibited differential expression dependent on sex, age, body mass index, and the presence of varying proportions of different leukocyte subsets were identified. These results emphasize the important contributions of genetic and environmental factors, as well as varying representation of different cell types, in determining the overall gene transcriptional profiles of human tissues. However, the study also provides evidence that, within an individual, the gene transcription profiles of sampled tissues can be comparatively stable over time.
Characterization of an extracellular asparaginase of<i>Rhodosporidium toruloides</i>CBS14 exhibiting unique physicochemical properties (1996)

An asparaginase specific for L-asparagine was purified from Rhodosporidium toruloides CBS14 to apparent homogeneity. The enzyme was associated with L-glutaminase activity (K m , 1.43 × 10 −3 M for L-asparagine and 6.45 × 10 −3 M for L-glutamine). The enzyme was found to be a homodimer with a subunit molecular mass of 87 kDa. Chemical modification of tryptophan residues significantly reduced both L-asparaginase and L-glutaminase activities of the enzyme, which was prevented by the presence of either of the substrates L-asparagine or L-glutamine. The pH and temperature optima for both activities were 6.35 and 37 °C. The enzyme was serologically identical with the asparaginases of some of the other Rhodotorula and Rhodosporidium yeasts but was distinct from the asparaginase of Saccharomyces cerevisiae.Key words: asparaginase, glutaminase, Rhodosporidium toruloides.
Principles and Applications of Interactive Corpus-Based Concatenative Synthesis (2008)

cote interne IRCAM: Schwarz08a
Supply chain integration scales validation and benchmark values (2013)

Purpose: The clarification of the constructs of the supply chain integration (clients, suppliers, external and internal), the creation of a measurement instrument based on a list of items taken from earlier papers, the validation of these scales and a preliminary benchmark to interpret the scales by percentiles based on a set of control variables (size of the plant, country, sector and degree of vertical integration). Design/methodology/approach: Our empirical analysis is based on the HPM project database (2005-2007 timeframe). The international sample is made up of 266 plants across ten countries: Austria, Canada, Finland, Germany, Italy, Japan, Korea, Spain, Sweden and the USA. In each country. We analized the descriptive statistics, internal consistency testing to purify the items (inter-item correlations, Cronbach’s alpha, squared multiple correlation, corrected item-total correlation), exploratory factor analysis, and finally, a confirmatory factor analysis to check the convergent and discriminant validity of the scales. The analyses will be done with the SPSS and EQS programme using the maximum likelihood parameter estimation method. Findings: The four proposed scales show excellent psychometric properties. Research limitations/implications: with a clearer and more concise designation of the supply chain integration measurement scales more reliable and accurate data could be taken to analyse the relations between these constructs with other variables of interest to the academic l fields. Practical implications: providing scales that are valid as a diagnostic tool for best practices, as well as providing a benchmark with which to compare the score for each individual plant against a collection of industrial companies from the machinery, electronics and transportation sectors. Originality/value: supply chain integration may be a major factor in explaining the performance of companies. The results are nevertheless inconclusive, the vast range of results obtained are due, amongst other things, to the fact that there is no exactness to the group of scales used, no-one has yet published an analysis of the measurement models nor clear benchmarks as to the variety of the scales used.
One-Step Transformation of Carboxylic Acids into Aldehydes Induced by the Electrochemical Oxidation of Ph3P. (1994)

Constant-current electrolysis (CCE) of Ph3P and a carboxylic acid (RCO2H, 1) in CH2Cl2 using a one-compartment cell equipped with two graphite plates as an anode and a cathode under a nitrogen atmosphere gave the corresponding aldehyde (2) when Ph3P+H·ClO-4 was used as a supporting electrolyte. The partial reduction was affected by the choice of electrolysis conditions, especially temperature and current density, depending on the structure of 1. Thus, the CCE of 1 with R=Ph-, o-Cl-Ph-, p-MeO-Ph-, Ph(CH2)2-, CH3(CH2)8-, Ph2CH-proceeded smoothly at -30°C in fair yields. In the case of 1 with R=cyclo-C6H11- and (CH3)2CH-, the electrolysis had to be carried out under reflux, and with R=(CH3)3C- the aldehyde was obtained only in a poor yield even under reflux. Based on the results of cyclic voltammetry of the anolyte obtained by the CCE of CH2Cl2 solutions of Ph3P, Ph3P+H·ClO-4, and 1 in a divided cell, the sequence of the partial reduction is proposed to be as follows : formation of acyloxy triphenylphosphonium ion (3) at the anode; the reaction of 3 with Ph3P to afford the corresponding acyl triphenylphosphonium ion (4); reduction of 4 to the α-hydroxyalkyl triphenylphosphonium ion (7) at the cathode; decomposition of 7 to 2 and Ph3P during the aqueous work-up after the CCE. The voltammetric study also suggested that the ease of the transformation of 3 to 4 is reflected in the required CCE conditions and may determine the yield of 2.
Present state of medication therapy in fibromyalgia syndrome (2000)

For the treatment of primary fibromyalgia syndrome (FMS) the low dose application of tri- and tetracyclic antidepressive drugs was often studied. Up to now from all those drugs the effects of amitriptyline (AMI) are best documented. Because of its sedative properties it doesn't only influence pain but also improves the often disturbed sleep. Its use in patients with FMS is limited by the occurrence of side effects and the lack of response in a substantial number of patients. Serotonin reuptake inhibitors alone seem to be of little value. Nevertheless there is evidence that they may improve pain in combination with other antidepressive agents. Regarding pain moclobemide a reversible inhibitor of monoamine oxidase seems to be inferior to AMI. In controlled studies corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) also failed to improve FMS. The combination of NSAIDs with benzodiazepines gave inconsistent results. Although often used, we have only small information about the effectiveness of opioids. No beneficial effect could be attributed to the muscle relaxant chlormezanone. In conclusion, although only about 1/3 of the patients respond, AMI remains the drug of first choice in the conventional medication treatment of FMS.
A 19-23 GHz integrated LC-VCO in a production 70 GHz fT SiGe technology (2004)

Integrated LC-VCOs for microwave frequencies are widely used nowadays. Traditionally, a lot of attention is paid to optimize the quality factor of the integrated inductor and varactor. The active part of the oscillator, used to undamp the resonator circuit, is often implemented as a cross-coupled differential pair. Even with a near-loss-less resonator circuit, this cross-coupled pair inherently puts a limit to the maximum attainable oscillation frequency. We derive a relation for this maximum attainable frequency f/sub cross/, and demonstrate a 19-23 GHz integrated LC-VCO approaching this theoretical limit for our IC-technology.
Novel biological markers of bone: from bone metabolism to bone physiology (2016)

Biochemical markers of bone turnover have been used for decades in the management of bone diseases, to assess the prognosis of these conditions and to monitor treatments. The new markers, however, also reflect specific physiological mechanisms in the bone or other organs. Periostin may be more specific to the periosteum; cathepsin K is an osteoclastic enzyme that may be involved in the cardiovascular system and joints; Dickkopf-1 is involved in bone formation and vascular calcification; sclerostin is a major regulator of bone formation in response to mechanical loading and may also play a role in chronic kidney disease bone and mineral disorder; sphingosine-1-phosphate is a lipid mediator interacting with bone resorption. Some of the bone markers are in fact hormones produced by the bone that affect various physiological and pathological functions in other organs. Thus, osteocalcin is produced by osteoblasts and participates in the regulation of insulin sensitivity and fertility in men. Fibroblast growth factor 23 is produced by osteocytes to regulate phosphorus and 1,25(OH)2D3, but it also plays a major role in the adverse consequences of declining renal function, in particular with respect to the myocardium. Micro RNAs are single-stranded RNAs that regulate several pathways, including the development timing, organogenesis, cell apoptosis, proliferation and differentiation. Their serum concentration may reflect the links between bone physiology and certain conditions in other organs, for example, the cardiovascular system.
1994 COMPILATION OF WORKING VALUES AND SAMPLE DESCRIPTION FOR 383 GEOSTANDARDS (1994)

In this Special Issue, working values are reported for 383 international geostandards along with sample description. All this information is available in the form of databases. The possibility of easily accessing data on geostandards from a microcomputer in the laboratory itself is an efficient means for handling quality control/ quality assurance problems.
Unrestrictive identification of post-translational modifications in the urine proteome without enrichment (2013)

In this study, we identified PTMs of urine proteins without the need for enrichment. Our investigation may provide a useful reference for biomarker discovery in the future.
Tailored Profiles Made of Tailor Rolled Strips by Roll Forming – Part 1 of 2 (2011)

Abstract To fully exploit the potential of sheet and profiles, various technologies to produce tailored blanks and profiles have been developed [1,2]. In earlier work [3] it has been shown that Strip Profile Rolling (SPR) can be used to produce metal strips with a predefined thickness distribution across the width of the strip. Building upon this knowledge, in two subsequent papers the extended goal of the project is presented. Therein is demonstrated that Strip Profile Rolling can be applied very effectively using a combination of roll forming (part 1) as well as further processing by roll forming (see part 2) to allow for the production of profiles with varying wall thickness in their cross section. To achieve the goal of part 1, a numerical model describing SPR was developed and used to study the influencing process parameters on spread and bulge formation. As a result of this parametric study, an optimized roll design and rolling sequence was developed to produce a demonstrator strip on a 12 stand roll forming mill manufactured by the company Dreistern [4]. Starting with a conventional strip out of DC01 steel (width 170 mm, thickness 2.5 mm), 29 rolling passes were necessary to achieve the desired geometry (width 186 mm, thickness 2.5 mm with a longitudinal groove being 64 mm wide where the thickness is reduced to 1.5 mm). In the second part of the process chain the coils produced by Strip Profile Rolling were successfully roll formed into a circular tube of 60 mm.
Reproductive failure due to spontaneous abortion and recurrent miscarriage (1996)

The epidemiology, aetiology, diagnosis and clinical management of spontaneous and recurrent abortion and of the failure of embryo implantation are discussed in a retrospective overview of the major studies conducted since 1975 identified through a Medline search. Infertile women who experienced spontaneous single (32%) and recurrent (0.5%) abortion as well as those who became pregnant after induction of ovulation with gonadotrophins (abortion rate 17-31%) and those who underwent assisted fertilization programmes (abortion rate 18-34%) are considered. Causes and treatments are here reported. Medical treatments for immunologically mediated abortion (IMA) are based on prednisolone, heparin, aspirin and intravenous immunoglobulin. Efficacy of the medical treatment of patients with a history of IMA has yet to be completely demonstrated. Genetic disorders are possible causes of both failure in implantation and early abortion; this cause is more prominent with advanced age and currently cannot be treated. Endocrine factors may also be responsible for miscarriage, and correction of hormone abnormalities is discussed. Infections, endometriosis and psychological factors are other possible important causes of embryo loss without specific widely accepted treatments. Prominent areas of research are the identification of genetic preimplantation abnormalities, and pharmacological intervention for abnormal spontaneous uterine contractility. The data here reported are encouraging, but the efficacy of different treatments is still not convincing. The information available is sufficient to develop new diagnostic and therapeutic tools to evaluate their efficacy in reducing spontaneous abortion at an early stage.
Preparation of polymer latex particles with immobilized sugar residues and their surface characterization by x-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of polymer latex particles with immobilized sugar residues and their surface characterization by x-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometryM. C. Davies, R. A. P. Lynn, S. S. Davis, J. Hearn, J. F. Watts, J. C. Vickerman, and A. J. PaulCite this: Langmuir 1993, 9, 7, 1637–1645Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/la00031a007https://doi.org/10.1021/la00031a007research-articleACS PublicationsRequest reuse permissionsArticle Views164Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Fetal growth in prolonged pregnancy]. (1989)

Posterm pregnancy still is a topic full of controversies in many aspects, such as diagnosis, perinatal risk and management. This paper suggests that a great number of fetuses from prolonged pregnancies, still grow after term, secondary to a persistent and adequate placental function; it's demonstrated, by comparing the distribution of newborn weights between term and posterm pregnancies. In the posterm group a significant increase in the incidence of hypertrophic newborns, is found. Dismature newborns, products of the placentary insufficiency in posterm pregnancy, although the point of interest of obstetricians, pediatricians and perinatologists because of its high rates of morbimortality, constitute a minority in comparison with fetus of posterm pregnancies with high newborn weights. It is possible that fetal hypertrophy by it self may be another cause of morbimortality in posterm pregnancies (because of dystocias, prolonged labor, altered fetopelvic relations, increased rates of cesarean sections, and others) that must be determined in future longterm, prospective analysis.
Stabilization of chaotic dynamics: a modern control approach (1996)

Modern techniques for dynamic control of chaotic systems are introduced. The problem of controlling chaos is addressed in the same conceptual framework as proposed by Ott, Grebogi and Yorke. However, the novelty here is the introduction of LQ and ℋ∞ techniques to address the problem. These techniques have been tested on representative systems, specifically the Logistic Map.
Kinetic mechanism of Halobacterium halobium Mn(2+)-activated alkaline phosphatase. (1994)

The extreme halophilic archaebacterium Halobacterium halobium contains an atypical alkaline phosphatase which is selectively activated by Mn2+ ions (Bonet et al., 1991: Int. J. Biochem. 23, 1445-1451). Enzyme kinetic mechanism in the presence of Mn2+ with p-nitrophenylphosphate as substrate was analysed by initial rate and product and competitive inhibition studies. The results indicate that there is an ordered addition of activator and substrate, Mn2+ being first in binding to the phosphatase, and that inorganic phosphate is the last product in leaving the enzyme active site. Strong inhibition by vanadate suggests that a phosphoenzyme intermediate is formed during enzymatic phosphohydrolysis of substrate.
A simple genetic algorithm for multiple sequence alignment. (2007)

Multiple sequence alignment plays an important role in molecular sequence analysis. An alignment is the arrangement of two (pairwise alignment) or more (multiple alignment) sequences of 'residues' (nucleotides or amino acids) that maximizes the similarities between them. Algorithmically, the problem consists of opening and extending gaps in the sequences to maximize an objective function (measurement of similarity). A simple genetic algorithm was developed and implemented in the software MSA-GA. Genetic algorithms, a class of evolutionary algorithms, are well suited for problems of this nature since residues and gaps are discrete units. An evolutionary algorithm cannot compete in terms of speed with progressive alignment methods but it has the advantage of being able to correct for initially misaligned sequences; which is not possible with the progressive method. This was shown using the BaliBase benchmark, where Clustal-W alignments were used to seed the initial population in MSA-GA, improving outcome. Alignment scoring functions still constitute an open field of research, and it is important to develop methods that simplify the testing of new functions. A general evolutionary framework for testing and implementing different scoring functions was developed. The results show that a simple genetic algorithm is capable of optimizing an alignment without the need of the excessively complex operators used in prior study. The clear distinction between objective function and genetic algorithms used in MSA-GA makes extending and/or replacing objective functions a trivial task.
Computers in language testing: Present research and some future directions (1997)

This article begins by exploring recent developments in the use of computers in language testing in four areas: (a) item banking, (b) computer-assisted language testing, (c) computerized-adaptive language testing, and (d) research on the effectiveness of computers in language testing.The article then examines the educational measurement literature in an attempt to forecast the directions future research on computers in language testing might take and suggests addressing the following issues: (a) piloting practices in computer adaptive language tests (CALTs), (b) standardizing or varying CALT lengths, (c) sampling CALT items, (d) changing the difficulty of CALT items, (e) dealing with CALT item sets, (f) scoring CALTS, (g) dealing with CALT item omissions, (h) making decisions about CALT cut-points, (i) avoiding CALT item exposure, (j) providing CALT item review opportunities, and (k) complying with legal disclosure laws when using CALTs.The literature on computer-assisted language learning indicates that language learners have generally positive attitudes toward using computers in the classroom (Reid, 1986;Neu & Scarcella, 1991;Phinney, 1991), and a fairly large literature has developed examining the effectiveness of computer-assisted language learning (for a review, see Dunkel, 1991).But less is known about the more specific area of computers in language testing.The purpose of this article is to examine recent developments in language testing that directly involve computer use including what we have learned in the process.The article will also examine the dominant issue of computer-adaptive testing in the educational measurement literature in an attempt to forecast some of the directions future research on computers in language testing might take. CURRENT STATE OF KNOWLEDGE ON COMPUTERS IN LANGUAGE TESTINGIn reviewing the literature on computers in language testing, I have found four recurring sets of issues: (a) item banking, (b) computer-assisted language testing, (c) computer-adaptive language testing, and (d) the effectiveness of computers in language testing.The discussion in this section will be organized under those four headings. Item BankingItem banking covers any procedures that are used to create, pilot, analyze, store, manage, and select test items so that multiple test forms can be created from subsets of the total "bank" of items.With a large item bank available, new forms of tests can be created whenever they are needed.Henning (1986) provides a description of how item banking was set up for the ESL Placement Examination at UCLA. (For further explanation and examples of item banking in educational testing, see Baker, 1989, pp.412-414, or Flaugher, 1990.)While the underlying aims of item banking can be accomplished by using traditional item analysis procedures (usually item facility and item discrimination indexes; for a detailed description of these
Adaptive mesh refinement for boundary element method and its application to stripline analysis (1990)

Adaptive mesh refinements are incorporated in the boundary element method (BEM) for accurate calculation of electromagnetic fields. Refinements are based on local error estimates of the calculated potential and its normal derivative on the boundaries. Differences between two adjacent node values are used for simple local error estimates. Also, error at the middle of each element is calculated from an integral equation. To demonstrate its applicability, this adaptive scheme is applied to striplines with edge singularity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Turbulent boundary layer on a rotating disk calculated with an effective viscosity (1971)

Skewed turbulent boundary layer and incompressible laminar flow on rotating disk, considering effective viscosity relations and applications domain