gebhart/patrepeval huggingface dataset:
Role of Extracellular Matrix in Regulating Fenestrations of Sinusoidal Endothelial Cells Isolated From Normal Rat Liver (1992)

Open fenestrations are a conspicuous feature of sinusoidal endothelial cells and allow free movement of plasma into the space of Disse. In hepatic fibrosis, the number of fenestrations decreases as interstitial collagen increases in the liver, a change that correlates with deposition of extracellular matrix in the space of Disse. In this study, the possibility of a causal relationship between altered fenestral morphology and perisinusoidal matrix has been examined by culturing rat sinusoidal endothelial cells on individual matrix proteins or on a native matrix consisting of human amniotic membrane with interstitial collagen (types I and III) on one side and basement membrane proteins (collagen types IV and V and laminin) on the other. Under culture conditions, individual components of the extracellular matrix failed to maintain fenestrations. A basement–membranelike gel matrix derived from the Engelbreth–Holm–Swarm tumor was similarly ineffective. Fenestral density and porosity (percentage of cell surface occupied by fenestrations) were significantly enhanced, however, when endothelial cells were cultured on the basement–membrane side of human amnion. These data suggest that support of endothelial fenestrations requires a complex matrix. In particular, physiologically derived basement membrane maintains fenestrations, whereas interstitial collagen matrix does not. The loss of fenestrations associated with hepatic fibrosis may be related in part to an accumulation of interstitial collagens in the space of Disse. (Hepatology 1992;15:989–997).
Radio Resource Allocation for OFDMA Systems in High Speed Environments (2012)

In high speed train (HST) system, real-time multimedia entertainments are very important applications in which a data stream often contains packets with different quality of service requirements. For example, video stream encoded with scalability contains the base layer packets with high quality (HQ) bit error rate (BER) requirement and enhancement layers' packets with low quality (LQ) BER requirement. When a conventional allocation approach, which only considers one BER constraint for one data stream, is applied to orthogonal frequency division multiple access (OFDMA) systems, the BER constraint will be the strictest one among multiple requirements from different types of packets, which leads to inefficient allocation when each data stream has multiple BER requirements. This paper aims to develop novel resource allocation approach by considering multiple BER requirements for different types of packets in one data stream. In order to not only simplify the resource allocation, but also to compensate for the channel estimation error caused by Doppler shift in the HST environment, a proper number of contiguous subcarriers are grouped into chunks and spectrum is allocated chunk by chunk. Simulation results show that the developed resource allocation scheme outperforms the conventional scheme, particularly when the BER ratio of HQ packets to LQ packets is larger than one. Furthermore, in order to reduce the complexity of resource allocation further, an empirical allocation scheme is proposed to allocate better chunks to HQ packets. It is shown that the performance of the empirical allocation scheme is quite close to that of the optimal scheme.
New type of starters (2010)

Practical operation shows that the overall reliability and durability of vehicles is affected, to large extent, by the starting characteristics of combustion engine, and also by the power and energy characteristics of the starting system. The presented work describes: overview of the starter types for passenger cars, new design concept of starters, requirements of the starting system, method for determining of starting parameters for some engines.
Magnetic binaries in the logical design of information handling machines (1952)

This paper presents a brief review of the magnetic binary, its circuit functions, the facts the logician needs in laying out a machine to utilize these, and the items to be specified so that the detailed circuit design may be established.Logical designs with magnetic binaries have two possible one-to-one correspondences with designs using vacuum tubes and crystal diodes. They give the designer more latitude than is possible with the use of tubes alone. Magnetic binary detail circuit design is, however, more complicated than vacuum-tube circuit design.
Simplified Light Reflection Technique for Orientation of Germanium and Silicon Crystals (1956)

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Synthesis, characterization and photocatalytic properties of titania-modified mesoporous silicate MCM-41 (2000)

A series of titania modified mesoporous silicate MCM-41 (MCM-TiO2) samples with variable Ti/Si ratios have been synthesized from tetrabutyltitanate and calcined MCM-41. The samples were characterized by powder X-ray diffraction (XRD), FTIR spectroscopy, thermal analysis (DTA–TG), nitrogen adsorption–desorption at 77 K, transmission electron microscopy (TEM), and solid state diffuse reflectance UV–VIS spectroscopy. It was found that tetrabutyltitanate cocondensation occurred with pendant OH groups of MCM-41 leading to Si–O–Ti bonds so modifying the inner pore surface of MCM-41 after hydrolysis and calcination. In the titania modified MCM-41 samples, although titania species were in tetrahedral rather than octahedral coordination which is predominant in crystalline titania, it still exhibited good photocatalytic activity for oxidizing phenol to carbon dioxide and water.
Efficiently train and validate a RapidPlan model through <scp>APQM</scp> scoring (2018)

Forward feeding a RapidPlan model through a thresholding selection based on APQM% is proven to produce equal or better results than a model based on a manually and iteratively refined population. A tighter APQM% threshold turns approximately into a higher average quality of plans generated with RapidPlan. A trade-off must be found between the mean quality of the KBP library and its numerosity. The proposed KBP feeding method helps the KBP user, because it makes the model refinement more intuitive and less time consuming.
Accidental hypothermia. Associated diagnoses and prognosis in a common problem (1974)

Sixteen patients with accidental hypothermia were admitted to the medical service of a general hospital in a one-year period. Analysis of the clinical status of the patients and the associated disease states showed that the underlying disease was more important in determining survival than the method of rewarming. Seven of eight patients with marked underlying organ system disease died, while all eight patients without severe organic disease survived even though the degree of hypothermia and time required for rewarming were similar in the two series. Slow passive rewarming is adequate therapy for most hypothermic patients, and major therapeutic efforts should be directed at underlying disease processes rather than the physiologic response to hypothermia.
Glutathione-Mediated Regulation of ATP Sulfurylase Activity, SO42- Uptake, and Oxidative Stress Response in Intact Canola Roots (1997)

The dual role of glutathione as a transducer of S status (A.G. Lappartient and B. Touraine [1996] Plant Physiol 111: 147-157) and as an antioxidant was examined by comparing the effects of S deprivation, glutathione feeding, and H2O2 (oxidative stress) on SO42- uptake and ATP sulfurylase activity in roots of intact canola (Brassica napus L.). ATP sulfurylase activity increased and SO42- uptake rate severely decreased in roots exposed to 10 mM H2O2, whereas both increased in S-starved plants. In split-root experiments, an oxidative stress response was induced in roots remote from H2O2 exposure, as revealed by changes in the reduced glutathione (GSH) level and the GSH/oxidized glutathione (GSSG) ratio, but there was only a small decrease in SO42- uptake rate and no effect on ATP sulfurylase activity. Feeding plants with GSH increased GSH, but did not affect the GSH/GSSG ratio, and both ATP sulfurylase activity and SO42- uptake were inhibited. The responses of the H2O2-scavenging enzymes ascorbate peroxidase and glutathione reductase to S starvation, GSH treatment, and H2O2 treatment were not to glutathione-mediated S demand regulatory process. We conclude that the regulation of ATP sulfurylase activity and SO42- uptake by S demand is related to GSH rather than to the GSH/GSSG ratio, and is distinct from the oxidative stress response.
Über eine neue Klasse von Siliconen mit Urotropin‐ Struktur (1955)

Abstract Alkyl‐trichlorsilane RSiCl 3 mit sperrigen Alkylresten R gehen in stark verdünnter ätherischer Lösung bei der Hydrolyse mit einer nach der Bruttogleichung berechneten Menge Wasser in Hydrolyse‐ und Kondensationsprodukte der Zusammensetzung und Molekulargröße [RSiO 1,5 ] 4 , eine neue Klasse von Siliconen mit Urotropin‐Struktur, über, während bei abnehmender Größe von R und zunehmender Konzentration der Hydrolyselösung die Bildung hochmolekularer Formen [RSiO 1,5 ] x , mit Blattstruktur begünstigt wird.
Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients (2015)

Background The transient receptor potential (TRP) superfamily in humans comprises 27 cation channels with permeability to monovalent and divalent cations. These channels are widely expressed within humans on cells and tissues and have significant sensory and regulatory roles on most physiological functions. Chronic fatigue syndrome (CFS) is an unexplained disorder with multiple physiological impairments. OBJECTIVES The purpose of this study was to determine the role of TRPs in CFS. Methods The study comprised 115 CFS patients (age = 48.68 ± 1.06 years) and 90 nonfatigued controls (age = 46.48 ± 1.22 years). CFS patients were defined according to the 1994 Center for Disease Prevention and Control criteria for CFS. A total of 240 single nucleotide polymorphisms (SNPs) for 21 mammalian TRP ion channel genes ( TRPA1, TRPC1, TRPC2, TRPC3, TRPC4, TRPC6, TRPC7, TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, TRPV1, TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) were examined via the Agena Biosciences iPLEX Gold assay. Statistical analysis was performed using the PLINK analysis software. Results Thirteen SNPs were significantly associated with CFS patients compared with the controls. Nine of these SNPs were associated with TRPM3 (rs12682832; P < 0.003, rs11142508; P < 0.004, rs1160742; P < 0.08, rs4454352; P < 0.013, rs1328153; P < 0.013, rs3763619; P < 0.014, rs7865858; P ≤ 0.021, rs1504401; P ≤ 0041, rs10115622; P ≤ 0.050), while the remainder were associated with TRPA1 (rs2383844; P ≤ 0.040, rs4738202; P ≤ 0.018) and TRPC4 (rs6650469; P ≤ 0.016, rs655207; P ≤ 0.018). Conclusion The data from this pilot study suggest an association between TRP ion channels, predominantly TRPM3 and CFS. This and other TRPs identified may contribute to the etiology and pathomechanism of CFS.
Multiple controls exerted on in vivo expression of the pepN gene in Escherichia coli: studies with pepN-lacZ operon and protein fusion strains (1985)

Three physiological conditions were shown to promote transcriptional regulation of pepN expression: phosphate limitation, the nature of the source of carbon and energy, and anaerobiosis. The transcriptional level of regulation can be deduced from the observation of these effects in strains carrying operon fusion pepN-lacZ. Mutations in the various genes phoB, phoM, phoR, crp, and fnr (oxrA) did not affect pepN expression.
Acquired coagulation inhibitor delaying fibrinopeptide release (1979)

A 14-yr-old girl Down syndrome developed a unique type of circulating inhibitor causing a mild bleeding tendency and interfering strongly with coagulation tests, including reptilase time, and with the reaction of purified fibrinogen and thrombin. The concentration of all coagulation factors was normal. The inhibitor had no direct effect on thrombin activity or on the aggregation of fibrin monomer in plasma. Chromatography on DEAE-cellulose and neutralization by immune sera revealed that the inhibitor was an immunoglobulin of IgG class with both kappa and lambda determinants. Isolated inhibitor delayed the release of fibrinopeptide A from a normal fibrinogen reacting with thrombin and retarded the onset of visible clotting, but had no effect on the the final degree of clottability. The clinical and laboratory features of this patient resemble those of patients with congenital dysfibrinogenemia associated with abnormal fibrinopeptide release.
A transformer-based low phase noise and widely tuned CMOS quadrature VCO (2006)

A VCO at 10GHz using the transformer-based LC tank in 0.18mum CMOS technology is designed. The LC tank is realized employing the drain-gate transformer feedback configuration. To apply to the pmos and nmos feedback path, two 2-port transformers are used. The 2-port transformer has symmetric structure and can be connected to enhance the quality factor of LC resonator. The simulated phase noise is -115dBc/Hz at the offset of 1MHz. The tuning range of 2.1GHz is achieved with the control voltage from 0V to 1.8V
A Low Complexity PAPR Reduction Scheme without Side Information for Pilot Assisted OFDM Systems (2008)

Selected Mapping (SLM) is a well known distortionless phase control Peak-to-Average-Power-Ratio (PAPR) reduction technique for Orthogonal Frequency Division Multiplexing (OFDM) systems. A major limitation of SLM-OFDM systems is that the receiver requires exact information of the phase set used at the transmitter. Usually side information (SI) is either transmitted explicitly at the loss of data rate or avoided using Blind SLM (BSLM) techniques at the expense of computational complexity. In the present work we investigate four SLM based PAPR reduction techniques and propose a new technique for pilot based SLM-OFDM systems which avoids the requirement of SI with low complexity. The proposed scheme involves cyclic shifting of pilots for each of the independent mapping in SLM systems. We compute a minimum distance vector at the receiver to detect the exact phase set used in the transmitter and avoid explicit transmission of SI. Bit Error Rate (BER) performance of the proposed scheme is evaluated in AWGN channels.
Analyse on Relay Maloperation of Assembling Capacitor Bank for Internal Fault Protection (2010)

In this paper, internal fault protective relay maloperation of assembling capacitor bank caused by switching-on transient harmonics is analyzed. Mathematical expressions describing the adaptive settings of single-wye, dual-wye and bridge connections are given. The realistic action of internal fault protections under high amplitude harmonic conditions is possibly very different from theoretic setting. Major impact of harmonic is to change the maximum allowed fault units in the capacitor banks on which the relay action settings are tight depend. The paper deduces this change under harmonic condition and actual investigation results corroborate the rationality of the research work. Corresponding measure against the relay maloperation is discussed.
Expression and Inheritance of Resistance of ‘Marquillo’ Wheat to Hessian Fly Biotype D<sup>1</sup> (1987)

Resistance of ‘Marquillo’ wheat ( Triticum aestivum L.) to the Hessian fly [ Mayetiola destructor (Say)] has been used effectively wheat cultivars for more than 30 yrs. Previous analyses of the genetic basis for resistance have been inconclusive. Our objectives were to determine the optimum temperature for expression of the Marquillo resistance in seedlings, to determine the number of genes controlling resistance to biotype D of Hessian fly, and to determine the relation of the Marquillo gene to other genes for resistance. We used biotype D of Hessian fly and standard methods of analysis of resistance of seedling progenies. The Marquillo resistance was expressed most consistently at 16°C. One partially dominant gene controlled resistance at this. temperature in crosses of Marquillo by susceptible cultivars. The Marquillo resistance appeared to be inherited independently from the H12 resistance in the F 2 plant progenies of Marquillo/ Luso crosses. Known dominance and genomic relationships imply that the Marquillo gene is distinct from all other known genes for resistance to biotype D of the Hessian fly.
Development, structure and senescence of colleters in Gardenia lucida Roxb. (Rubiaceae) (2014)

Colleters are found on the adaxial basal part of the stipule and calyx of <em>Gardenia lucida</em>. They secrete a yellow transparent resinous substance commonly known as "Dikamali gum". They develop on both the stipule and calyx from a group of epidermal and hypodermal initials. A mature colleter consists of a central core of elongated parenchymatous cells surrounded by a palisade-like secretory epidermis. Druses type crystals of calcium oxalate are frequent in the colleters. At the time of senescence the central cells show lignification and the presence of tannin.
Nucleotide Sequence of the Gene Encoding the Spike Glycoprotein of Human Coronavirus HCV 229E (1990)

The gene encoding the spike glycoprotein of the human coronavirus HCV 229E has been cloned and sequenced. This analysis predicts an S polypeptide of 1173 amino acids with an Mr of 128,600. The polypeptide has 30 potential N-glycosylation sites. A number of structural features typical of coronavirus S proteins can be recognized, including a signal sequence, a membrane anchor, heptad repeat structures and a carboxy-terminal cysteine cluster. A detailed, computer-aided comparison with the S proteins of infectious bronchitis virus, feline infectious peritonitis virus, transmissible gastroenteritis virus and murine hepatitis virus, strain JHM is presented. We have also done a Northern blot analysis of viral RNAs in HCV 229E-infected cells using synthetic oligonucleotides. On the basis of this analysis, and by analogy to the replication strategy of other coronaviruses, we are able to propose a model for the organization and expression of the HCV 229E genome.
Transgenic Plant Cells Lacking Mitochondrial Alternative Oxidase Have Increased Susceptibility to Mitochondria-Dependent and -Independent Pathways of Programmed Cell Death (2002)

The plant mitochondrial electron transport chain is branched such that electrons at ubiquinol can be diverted to oxygen via the alternative oxidase (AOX). This pathway does not contribute to ATP synthesis but can dampen the mitochondrial generation of reactive oxygen species. Here, we establish that transgenic tobacco (Nicotiana tabacum L. cv Petit Havana SR1) cells lacking AOX (AS8 cells) show increased susceptibility to three different death-inducing compounds (H(2)O(2), salicylic acid [SA], and the protein phosphatase inhibitor cantharidin) in comparison with wild-type cells. The timing and extent of AS8 cell death are very similar among the three treatments and, in each case, are accompanied by the accumulation of oligonucleosomal fragments of DNA, indicative of programmed cell death. Death induced by H(2)O(2) or SA occurs by a mitochondria-dependent pathway characterized by cytochrome c release from the mitochondrion. Conversely, death induced by cantharidin occurs by a pathway without any obvious mitochondrial involvement. The ability of AOX to attenuate these death pathways may relate to its ability to maintain mitochondrial function after insult with a death-inducing compound or may relate to its ability to prevent chronic oxidative stress within the mitochondrion. In support of the latter, long-term treatment of AS8 cells with an antioxidant compound increased the resistance of AS8 cells to SA- or cantharidin-induced death. The results indicate that plants maintain both mitochondria-dependent and -independent pathways of programmed cell death and that AOX may act as an important mitochondrial "survival protein" against such death.
Catalase inhibition alters suberization and wound healing in potato (<i>Solanum tuberosum</i>) tubers (2007)

In response to wounding, potato ( Solanum tuberosum L.) tubers generate hydrogen peroxide (H 2 O 2 ) in association with suberization, a critical phase of the wound‐healing process. In the present study, the effect of aminotriazole (AT), a catalase (CAT, EC 1.11.1.6) inhibitor, on cut tubers was investigated using fresh weight (FW) loss and pathogen attack symptoms as indicators of wound‐healing efficiency. Seven days after treatment, AT‐treated tuber halves lost more FW and developed infection signs compared with the controls. Thiourea, another CAT inhibitor, as well as exogenous H 2 O 2 treatments induced the same effects as AT suggesting that the alteration of the wound healing may be caused by CAT inhibition and the resulting accumulation of H 2 O 2 . Using transgenic tubers, FW losses 1 week after wounding were either higher (CAT repression) or lower (CAT overexpression) than those of the wild‐type. When tuber halves were allowed to wound heal for different periods before treatment, AT had no effect on the progress of their wound healing if wound‐healed for at least 3 days. This implies that AT may affect early wound‐healing‐related events, especially those occurring before or during suberization. A time‐course analysis of the effects of AT treatment on wounded tuber tissues revealed that AT prevented the deposition of the polyphenolic domain of suberin in association with CAT inhibition and H 2 O 2 accumulation. These data are important in identifying factors that may be required to regulate suberization and contribute to a better understanding of this critical process to hasten its rate and limit wound‐related losses in stored potato tubers.
StratusPM: An Analytical Performance Model for Cloud Applications (2016)

Several planning and performance analysis tools and techniques are available to execute sophisticated "what-if" analysis, in order to dynamically reconfigure cloud applications, modify them, and update their adaptation policies. However, in order to utilize these tools and techniques, appropriate analytical models for such cloud software systems must first be built. Constructing such models is difficult, as it requires the knowledge of: (i) the architecture of the system (i.e., deployment model), (ii) the specifications of the platform, (iii) the behavior of the application at runtime, and (iv) the formalism and notations of the target analytical model. This is further complicated in the cloud due to: (i) the fluid nature of the cloud application models and platforms, (ii) the large number of platform providers, and (iii) the successive upgrade to the underlying platforms. In our previous research work, we developed an architectural framework and a modeling language for the cloud configuration space called StratusML. This paper aims at extending StratusML to support generating analytical performance models for cloud applications by reusing the information used to configure the platform for the deployment and the operation. We show through an example, how to use StratusPM to model cloud performance and how the new extension can help reducing the efforts needed to specify analytical performance models for cloud applications.