gebhart/patrepeval huggingface dataset:
Zirconium organophosphonates as photoactive and hydrophobic host materials for sensitized luminescence of Eu(<scp>iii</scp>), Tb(<scp>iii</scp>), Sm(<scp>iii</scp>) and Dy(<scp>iii</scp>) (2004)

Novel luminescent materials based on lanthanides [Eu(III), Tb(III), Sm(III), and Dy(III)] and a mixed zirconium phenyl- and m-sulfophenyl phosphonate as the host matrix, have been prepared and photophysically characterized. Powder X-ray diffraction, 31P-MAS-NMR spectroscopy, IR spectroscopy, and diffuse-reflectance UV spectroscopy revealed the specificity of these materials such as a layered structure, the presence of phenyl groups in the galleries, and the ability to absorb lanthanide ions introduced by simple ion exchange. Characteristic line-shaped long-lived luminescence [ca. 0.27 ms for Eu(III), 0.80 ms for Tb(III), and 0.05 ms for Sm(III)] was observed for different lanthanide ions, and was demonstrated to be generated by an antenna-induced energy transfer process to the metal. The overall luminescence quantum yield of europium- or terbium-loaded materials was measured to be ca. 0.3%. A detailed analysis of the Eu(III) luminescence spectrum and H2O/D2O exchange experiments indicated the presence of ca. 3 water molecules around each lanthanide. Based on the high maximum coordination numbers of lanthanides, up to 9 for free Eu(III) in aqueous solutions, and the presence of only monodentate sulfonate binding sites, more water could be expected. This observation is explained by the rather hydrophobic microenvironment in the interlamellar space of the materials, due to pendant organic moieties, that is, the phenyl groups.
The Toxicity of Soman in the African Green Monkey (<i>Chlorocebus aethiops</i>) (2007)

ABSTRACT This study determines soman toxicity in African green monkeys (Chlorocebus aethiops) and is the first step in exploring the suitability of this species as a model for nerve agent studies. Male African green monkeys were surgically implanted with telemetry devices to monitor electroencephalographic (EEG) and electrocardiographic (ECG) activity. Blood was taken at various times to measure whole blood acetylcholinesterase (AChE) activity and cardiac troponin I (cTnI). Blood AChE activity relative to baseline was 0.0% to 2.5% 6 h after soman exposure and recovered to 31.9% to 72.0% by 30 days after exposure. The 6 h postexposure cTnI levels varied from 0.64 to 6.55 ng/mL, suggesting cardiac damage. Soman was prepared in saline to a concentration of 100 mug/mL. Using an up-down design for small samples, subjects were exposed to 5.01, 6.31, or 7.94 mug/kg soman IM. The first subject was given 5.01 mug/kg soman IM and survived. Three subjects received 6.31 mug/kg soman IM and survived. Three subjects received 7.94 mug/kg soman IM and died within 25 min, 26 min, or 6 h. In all subjects, toxic signs of muscle fasciculation, tremors, chewing, and profuse salivation developed within 2 to 7 min. Tonic-clonic motor convulsions and EEG seizure began between 2 and 18 min after tremor onset. The 48 h IM LD50 of soman in saline in the African green monkey was calculated to be 7.15 mug/kg. The signs and speed of soman intoxication in African green monkeys were consistent with those described in rhesus, cynomolguscynomolgus, and baboons.
Identification of the targets required for the anti-tumor effect of celecoxib and its non-COX-2 inhibitory derivative (2015)

The non-steroidal anti-inflammatory drug (NSAID) celecoxib (Celebrex�) was specifically developed as a selective cyclooxygenase-2 (COX-2) inhibitor. It is well established that COX-2 plays a role in carcinogenesis, and COX inhibitors have been shown to exert chemopreventive abilities. However, their usefulness for the treatment of established cancers is much less clear. It has emerged that celecoxib is unique, as it might have potential for the treatment of various types of cancer. In my work, I could demonstrate that celecoxib's anti-tumor properties are not related to its inhibition of COX-2. This is further evident by our development of 2,5-dimethyl-celecoxib (DMC), a close structural analog of celecoxib that lacks COX-2-inhibitory function, yet is able to potently mimic the anti-tumor effects of celecoxib in vitro and in vivo, indicating that these drugs exert their cytotoxic effects by affecting different targets other than COX-2.
Prognostic value of circulating regulatory T cell subsets in untreated non-small cell lung cancer patients (2016)

The role of the different circulating regulatory T-cells (Treg) subsets, as well as their correlation with clinical outcome of non-small cell lung cancer (NSCLC) patients is poorly understood. Peripheral blood from 156 stage III/IV chemotherapy-naive NSCLC patients and 31 healthy donors (HD) was analyzed with flow cytometry for the presence and functionality of CD4<sup>+</sup> Treg subsets (naive, effector and terminal effector). Their frequencies were correlated with the clinical outcome. All CD4<sup>+</sup> Treg subsets exhibited highly suppressive activity by TGF-β and IL-10 production. The percentages of naive Treg were found elevated in NSCLC patients compared to HD and were associated with poor clinical outcome, whereas the percentage of terminal effector Treg was lower compared to HD and higher levels were correlated with improved clinical response. At baseline, normal levels of naive and effector Treg were associated with longer overall survival (OS) compared to high levels, while the high frequency of the terminal effector Treg was correlated with longer Progression-Free Survival and OS. It is demonstrated, for first time, that particular CD4<sup>+</sup> Treg subtypes are elevated in NSCLC patients and their levels are associated to the clinical outcome. The blocking of their migration to the tumor site may be an effective therapeutic strategy.
Dynamical mechanical analysis of photocrosslinked hyperbranched urethane acrylates (2004)

A series of acrylate functionalized samples based on hyperbranched hydroxy-terminated polyesters with different molecular weights and different degrees of acrylation were synthesized. The obtained urethane acrylates were slightly yellow viscose liquids. Their composition was characterized by FTIR and 1H-NMR spectroscopy and their molecular weights were measured by GPC. All the synthesized samples were diluted with 25 wt.% 1,4-butanediol dimethacrylate (BDDM). The rheological properties of the uncured samples and the dynamic mechanical properties of the UV cured samples were examined. All the samples exhibit Newtonian behavior, which indicates the absence of physical entanglements in these polymers. The viscosity increases with increasing number of acrylic groups permolecule. The glass transition temperature of the UV cured samples increases with increasing the number of acrylic groups permolecule. The value of the storage modulus in the rubber-elastic plateau and the cross-link density increase with increasing number of acrylic groups permolecule. The formed networks are inhomogeneous and the residual unsaturation is the highest in the samples with the largest number of acrylic groups per molecule.
Generalized Minkowski metrics for mixed feature-type data analysis (1994)

This paper presents simple and convenient generalized Minkowski metrics on the multidimensional feature space in which coordinate axes are associated with not only quantitative features but also qualitative and structural features. The metrics are defined on a new mathematical model (U/sup (d/),[+], [X]) which is called simply the Cartesian space model, where U/sup (d/) is the feature space which permits mixed feature types, [+] is the Cartesian join operator which yields a generalized description for given descriptions on U/sup (d/), and [X] is the Cartesian meet operator which extracts a common description from given descriptions on U/sup (d/). To illustrate the effectiveness of our generalized Minkowski metrics, we present an approach to the hierarchical conceptual clustering, and a generalization of the principal component analysis for mixed feature data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Doctoral thesis recital (piano) (2018)

Sonata no. 17 in B flat major, K. 570 / W.A. Mozart -- From Iberia. El Albaicín, book 3 no. 1 / Isaac Albéniz -- Sonata no. 4 in f-sharp major, op. 30 / Alexander Scriabin -- Mazurka in A minor, op. 17 no. 4 ; Mazurka in C major, op. 33 no. 2 ; Ballade no. 1 in G minor, op. 23 / Frederic Chopin -- Après une lecture du Dante : fantasia quasi sonata / Franz Liszt.
Quantum Size Effect in ZnO Nanoparticles via Mechanical Milling (2012)

ZnO nanocrystals were successfully produced by mechanical milling. It is shown that mechanical milling is very effective and simple to produce ZnO nanoparticles with the possibility of obtaining large quantities of materials. Size effects in ZnO nanoparticles were probed by XRD and UV‐vis and photoluminescence (PL) spectroscopy. Absorption due to free electron was clearly observed, whereas strong PL lines were recorded in the UV and blue region. The absorbance and photoluminescence were found to increase with reduction in particle size. Blueshift of excitonic and emission peaks was observed as a consequence of the size quantization effect. Formation of pure ZnO phase was confirmed from XRD pattern and the optical spectroscopy.
Action of admixtures on Fondu cement: Part 1. Lithium and sodium salts compared (1996)

Measuring the conductivity of stirred and diluted suspensions of Fondu cement enables the action of admixtures on the dissolution and induction periods to be determined. These events occur before the massive precipitation of hydrates leading to setting of the paste. These new results, compared to those obtained on paste, are useful in determining the mechanisms of interaction between Fondu cement hydration and admixtures. The behaviour of lithium and sodium salts is a result of the sum of the interactions due to their cationic and anionic parts. Experiments with lithium salts seem to be compatible with the hypothesis of an induction period kinetically controlled by a nucleation and growth process of AH 3 at 2°C
Parametric Range Estimating of Building Costs Using Regression Models and Bootstrap (2008)

This paper presents a bootstrap approach for integration of parametric and probabilistic cost estimation techniques. In the proposed method, a combination of regression analysis and bootstrap resampling technique is used to develop range estimates for construction costs. The method is applied to parametric range estimation of building projects as an example. The bootstrap approach includes advantages of probabilistic and parametric estimation methods, at the same time it requires fewer assumptions compared to classical statistical techniques. This study is of relevance to practitioners and researchers, as it provides a robust method for conceptual estimation of construction costs.
A peptidase in human platelets that deamidates tachykinins. Probable identity with the lysosomal "protective protein". (1990)

We discovered an enzyme in human platelets that deamidates substance P and other tachykinins. Because an amidated carboxyl terminus is important for biological activity, we purified and characterized this deamidase. The enzyme, released from human platelets by thrombin, was purified to homogeneity by ammonium sulfate precipitation, followed by chromatography on an octyl-Sepharose column and chromatofocusing on PBE 94. The purified enzyme exhibits esterase, peptidase, and deamidase activities. The peptidase activity (with furylacryloyl-Phe-Phe) is optimal at pH 5.0 while the esterase (benzoyl-tyrosine ethyl ester) and deamidase (D-Ala2-Leu5-enkephalinamide) activities are optimal at pH 7.0. With biologically important peptides, the enzyme acts both as a deamidase (substance P, neurokinin A, and eledoisin) and a carboxy-peptidase (with bradykinin, angiotensin I, substance P-free acid, oxytocin-free acid) at neutrality, although the carboxypeptidase action is faster at pH 5.5. Enkephalins, released upon deamidation of enkephalinamides, were not cleaved. Gly9-NH2 of oxytocin was released without deamidation. Peptides with a penultimate Arg residue were not hydrolyzed. Some properties of the deamidase are similar to those reported for cathepsin A. The deamidase is inhibited by diisopropylfluorophosphate, inhibitors of chymotrypsin-type enzymes, and mercury compounds while other inhibitors of catheptic enzymes, trypsin-like enzymes, and metalloproteases were ineffective. In gel filtration, the native enzyme has an Mr = 94,000 while in non-reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis the Mr = 52,000 indicating it exists as a dimer. After reduction, deamidase dissociates into two chains of Mr = 33,000 and 21,000 as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. [3H]diisopropylfluorophosphate labeled the active site serine in the Mr = 33,000 chain. The first 25 amino acids of both chains were sequenced. They are identical with the sequences of the two chains of lysosomal "protective protein" which, in turn, has sequence similarity to the KEX1 gene product and carboxypeptidase Y of yeast. This protective protein complexes with beta-galactosidase and neuraminidase in lysosomes and is vitally important in maintaining their activity and stability. A defect in this protein is the cause of galactosialidosis, a severe genetic disorder. The ability of physiological stimuli (e.g. thrombin or collagen) to release the deamidase from platelets indicates that it may also be involved in the local metabolism of bioactive peptides.
A software development process model for gesture-based interface (2012)

Gesture-based applications have particularities, since users interact in a natural way, much as they interact in the non-digital world. Hence, new requirements are needed on the software design process. This paper shows a software development process model for these applications, including requirement specification, design, implementation, and testing procedures. The steps and activities of the proposed model were tested through a game case study, which is a puzzle game. The puzzle is completed when all pieces of a painting are correctly positioned by the drag and drop action of users hand gesture. It also shows the results obtained of applying a heuristic evaluation on this game.
<i>RPGR-</i>associated retinopathy: clinical features, molecular genetics, animal models and therapeutic options (2016)

Retinitis pigmentosa GTPase regulator (RPGR) gene sequence variants account for the vast majority of X linked retinitis pigmentosa (RP), which is one of the most severe forms of RP. Symptoms of nyctalopia typically begin in childhood, with increasing loss of peripheral visual field during teenage years, and progressive central visual loss during the second to fourth decade of life. There is however marked intrafamilial and interfamilial phenotypic heterogeneity in affected males and carrier females. There is now a far greater understanding of the range of phenotypes associated with variants in this gene; including rod-cone dystrophy, cone-rod dystrophy, cone dystrophy, macular dystrophy and non-ocular phenotypes. There are also increasingly established genotype-phenotype associations and structure-function correlations. RPGR is involved in ciliary function, with ciliary dysfunction now recognised as the mechanism underlying a large proportion of inherited retinal disease. There has been significant progress in identifying naturally occurring animal models and developing novel models to define the underlying disease mechanisms and to test gene replacement therapy, in addition to advances in human retinal imaging, culminating in completed and planned clinical trials. These significant developments will be discussed.
Detection of Crime Patterns in Digital Forensic Investigation to Trace the Adversaries (2021)

The use of the internet has increased significantly over the past couple of years. Access to the internet has become so common that a person without computer knowledge can also use this facility easily. This ease of availability has provided a lot of benefits to society but on the other hand misuse of the internet for personal or corporate benefits is also increasing. To prosecute cybercriminals and make some lawful checks on everyone's digital activities, digital forensic science comes into the light. In this context, we developed a new framework that improves the digital forensic investigation process. This research paper proposes a method in which we can identify the illegal activities and trace the adversaries. We capture the TCP (Transmission Control Protocol) packets from the servers and workstations. This data collected from the TCP log is stored in the database and preprocessed to eliminate redundant data. Furthermore, the database also contains past data. The proposed framework has three major processes collection of TCP packets, storing and preprocessing of collected data in a database, and mining of the pattern through a digital forensic anomaly collection algorithm. For the evaluation of our proposed framework, we have developed a java based application. The results are shown in the form of reports and tables.
The potential of CD4 T‐cell memory (2010)

While many aspects of memory T-cell immunobiology have been characterized, we suggest that we know only a fraction of the effector functions that CD4 T cells can bring to bear during secondary challenges. Exploring the full impact of memory CD4 T-cell responses is key to the development of improved vaccines against many prominent pathogens, including influenza viruses, and also to a better understanding of the mechanisms of autoimmunity. Here we discuss factors regulating the generation of memory CD4 T cells during the activation of naïve cells and how the nature of the transition from highly activated effector to resting memory upon the resolution of primary responses might impact memory CD4 T-cell heterogeneity in vivo. We stress that memory CD4 T cells have unique functional attributes beyond the secretion of T helper (Th) subset-associated cytokines that can shape highly effective secondary responses through novel mechanisms. These include the recruitment of innate inflammatory responses at early phases of secondary responses as well as the action of enhanced direct effector functions at later phases, in addition to well-established helper roles for CD8 T-cell and B-cell responses.
Influenza A virus inhibits cytoplasmic stress granule formation (2011)

An important component of the mammalian stress response is the reprogramming of translation. A variety of stresses trigger abrupt polysome disassembly and the accumulation of stalled translation preinitiation complexes. These complexes nucleate cytoplasmic stress granules (SGs), sites of mRNA triage in which mRNAs from disassembling polysomes are sorted and the fates of individual transcripts are determined. Here, we demonstrate that influenza A virus (IAV) actively suppresses SG formation during infection, thereby allowing translation of viral mRNAs. Complete inhibition of SG formation is dependent on the function of the viral nonstructural protein 1 (NS1); at late times postinfection, cells infected with NS1-mutant viruses formed SGs in a double-stranded RNA-activated protein kinase (PKR)-dependent fashion. In these cells, SG formation correlated with inhibited viral protein synthesis. Together, these experiments demonstrate the antiviral potential of SGs and reveal a viral countermeasure that limits SG formation.
Evidence for Macroscopic Quantum Tunneling in One-Dimensional Superconductors (1988)

Measurements of the superconducting-to-normal transition in very-small-diameter In wires are presented. The results are discussed in terms of the currently accepted theory, in which dissipation below ${T}_{c}$ is attributed to thermally activated motion of the Ginzburg-Landau order parameter over the free-energy barriers which separate metastable states. This theory is consistent with our results for temperatures within about 0.2 K of ${T}_{c}$, but at lower temperatures it fails qualitatively. We suggest that the low-temperature behavior is dominated by quantum-mechanical tunneling through the free-energy barrier, and show that our results are consistent with this picture.
CO<sub>2</sub>-Enhanced Thermolytic H<sub>2</sub> Release from Ammonia Borane (2011)

This work presents the accelerated dehydrogenation of ammonia borane (AB) at 85 °C under carbon dioxide atmosphere. The presence of CO2 significantly enhances the thermolysis kinetics, and the hydrogen release becomes faster as the CO2 pressure increases from 1.70 to 3.67 bar. Around 4 bar of CO2, 1.33 equiv of hydrogen is released from AB in 1 h. The accelerated AB thermolysis is due to CO2 reacting with AB, or intermediates like diammoniate of diborane (DADB), or primary thermolysis products including linear dimers of aminoborane (LDAB), which accelerates AB thermolysis, and this reaction has been confirmed by ATR-FTIR, Raman, and 11B and 13C solid-state MAS NMR measurements.
<title>Spatiotemporal multiscan adaptive matched filtering</title> (1995)

Detecting the presence of small weak targets in nonstationary clutter backgrounds is a fundamental problem in representative IR surveillance and tracking systems. In this paper, a system is proposed using spatiotemporal adaptive matched filtering to suppress the effects of clutter and enhance target detection. Shortfalls in conventional adaptive systems lead to a multiple parallel scanning approach to eliminate transients resulting from suboptimal filtering at clutter edges. Simulation results are provided which demonstrate that this approach provides substantially superior performance to a non-adaptive matched filter detection system design using global clutter statistics and, in some cases, can even achieve performance approximating that of an ideal fully-adaptive detector design from the complete statistical knowledge of the nonstationary clutter.
De Sean MacBride a la propuesta de la radio comunitaria en Piura-Perú (2014)

La presente reflexión tiene como objetivo resaltar la importancia de la radio comunitaria, sobre todo en las zonas alejadas de las grandes ciudades. Nos interesa plantear una visión, a través de la historia, sobre el surgimiento de las radios comunitarias. Para algunos expertos, el Informe MacBride es el punto de partida. De dicho informe se recoge la principal conclusión: el Nuevo Orden Mundial de la Información y de la Comunicación fue un proyecto de reorganización de los flujos globales de información a través de distintas acciones, iniciativa que recibió el apoyo de la Unesco. El Informe propuso cambios para redistribuir y balancear los flujos de información entre países desarrollados y subdesarrollados.
Effect of Normal Aging and of Alzheimer's Disease on Episodic Memory (1997)

Performances of 12 patients with Alzheimer's disease (AD), 15 healthy elderly subjects and 20 young healthy volunteers were compared on two episodic memory tests. The first, a learning test of semantically related words, enabled an assessment of the effect of semantic relationships on word learning by controlling the encoding and retrieval processes. The second, a dual coding test, is about the assessment of automatic processes operating during drawings encoding. The results obtained demonstrated quantitative and qualitative differences between the population. Manifestations of episodic memory deficit in AD patients were shown not only by lower performance scores than in elderly controls, but also by the lack of any effect of semantic cues and the production of a large number of extra-list intrusions. Automatic processes underlying dual coding appear to be spared in AD, although more time is needed to process information than in young or elderly subjects. These findings confirm former data and emphasize the preservation of certain memory processes (dual coding) in AD which could be used in future therapeutic approaches.