gebhart/patrepeval huggingface dataset:
Increased Bioactive Lipids Content in Human Subcutaneous and Epicardial Fat Tissue Correlates with Insulin Resistance (2012)

Obesity is a risk factor for metabolic diseases. Intramuscular lipid accumulation of ceramides, diacylglycerols, and long chain acyl-CoA is responsible for the induction of insulin resistance. These lipids are probably implicated in obesity-associated insulin resistance not only in skeletal muscle but also in fat tissue. Only few data are available about ceramide content in human subcutaneous adipose tissue. However, there are no data on DAG and LCACoA content in adipose tissue. The aim of our study was to measure the lipids content in human SAT and epicardial adipose tissue we sought to determine the bioactive lipids content by LC/MS/MS in fat tissue from lean non-diabetic, obese non-diabetic, and obese diabetic subjects and test whether the lipids correlate with HOMA-IR. We found, that total content of measured lipids was markedly higher in OND and OD subjects in both types of fat tissue (for all p < 0.001) as compared to LND group. In SAT we found positive correlation between HOMA-IR and C16:0-Cer (r = 0.79, p < 0.001) and between HOMA-IR and C16:0/18:2 DAG (r = 0.56, p < 0.001). In EAT we found a strong correlation between C16:0-CoA content and HOMA-IR (r = 0.73, p < 0.001). The study showed that in obese and obese diabetic patients, bioactive lipids content is greater in subcutaneous and epicardial fat tissue and the particular lipids content positively correlates with HOMA-IR.
A Microfluidic Paper‐Based Origami Nanobiosensor for Label‐Free, Ultrasensitive Immunoassays (2016)

Microfluidic paper-based analytical devices (μPADs) represent a promising platform technology for point-of-care diagnosis. Highly sensitive, rapid, and easy-to-perform immunoassays implemented on μPADs are desirable to fulfill the promise of the μPAD technology. This article reports the first microfluidic paper-based origami nanobiosensor (origami μPAD), which integrates zinc oxide nanowires (ZnO NWs) and electrochemical impedance spectroscopy (EIS) biosensing mechanism, for label-free, ultrasensitive immunoassays. The EIS mechanism features simple and label-free assay operations which take less than 25 min to be finished, while the ZnO NWs allow covalent bonding for immobilizing probe proteins and improve the biosensing performance with such features as high surface-area-to-volume ratios and high sensitivity to surface binding. The calibration of the device reveals an ultralow limit of detection (LOD) of 60 fg mL(-1) (>100 times lower than those of existing μPADs) for rabbit immunoglobulin G in phosphate-buffered saline. The detection of human immunodeficiency virus p24 antigen in human serum with a low LOD of 300 fg mL(-1) (>33 times lower than that of a commercial p24 antigen test kit) is also demonstrated. This novel μPAD design offers ultrahigh sensitivity, short assay time, and ease of operation, and thus possesses significant potential for low-cost, rapid molecular diagnosis of early-stage diseases.
A Clamp Mechanism for Deployable Three-Ton Payloads (1981)

The requirements, capabilities, and unique design features of the instrument payload subsystem payload clamp assembly (PCA) are presented. The PCA is designed to have the flexibility to accommodate a wide payload range varying from 0.5 m to 3 m in diameter and from 500 kg to 3000 kg mass. This is achieved by modular clamp design in connection with replaceable struts. The design features include clamping of payload in a statically determined way and actuation of clamp latches by means of single linear actuator via ropes. The vibration and TV environmental conditions for the mechanism are extremely severe. A structural and prototype model was built. Test results of the operating characteristic are presented. In addition, problems of tribology are highlighted.
Decentralized coordination of dynamic software updates in the Internet of Things (2016)

Large scale IoT service deployments run on a high number of distributed, interconnected computing nodes comprising sensors, actuators, gateways and cloud infrastructure. Since IoT is a fast growing, dynamic domain, the implementation of software components are subject to frequent changes addressing bug fixes, quality insurance or changed requirements. To ensure the continuous monitoring and control of processes, software updates have to be conducted while the nodes are operating without losing any sensed data or actuator instructions. Current IoT solutions usually support the centralized management and automated deployment of updates but are restricted to broadcasting the updates and local update processes at all nodes. In this paper we propose an update mechanism for IoT deployments that considers dependencies between services across multiple nodes involved in a common service and supports a coordinated update of component instances on distributed nodes. We rely on LyRT on all IoT nodes as the runtime supporting local disruption-minimal software updates. Our proposed middleware layer coordinates updates on a set of distributed nodes. We evaluated our approach using a demand response scenario from the smart grid domain.
Irrigation of Grassland (1959)

Grassland in the drier parts of England frequently suffers from drought in the summer months, but it is rarely irrigated and there has been little experimental evidence to show either when to irrigate or how much water to apply. Technical data on both points and on the effects of irrigation and nitrogen treatments on the yield and composition of leys are provided by the trials described here, though the practical aspects are not considered.
Making your PC behave like another (1986)

The emulation of one personal computer (PC) by another is considered. The meaning of the term `emulation' is examined, and current approaches are described. A table of specifications for selected personal-computer emulators is included, and innovative products that are emerging are described. The underlying approach to emulation is examined, and the problems involved in splitting functions between processors and using peripherals are discussed.
Studies of anti‐f(ab')<sub>2</sub> antibodies and possible immunologic control mechanisms in systemic lupus erythematosus (1984)

Studies of anti-DNA and anti-F(ab')2 antibodies were performed by enzyme-linked immunosorbent assay in 51 patients with systemic lupus erythematosus (SLE). Patients with severe, uncontrolled disease showed high levels of anti-DNA and low levels of anti-F(ab')2 antibodies. Patients with quiescent SLE usually showed high levels of anti-F(ab')2 and low levels of anti-DNA antibodies. Isolated anti-F(ab')2 antibodies from autologous SLE remission serum or from the sera of unaffected siblings of SLE patients showed maximum inhibition in test systems using affinity-purified SLE anti-DNA antibodies reacting with single-stranded DNA.
A Receptor That Subserves Reovirus Binding Can Inhibit Lymphocyte Proliferation Triggered by Mitogenic Signals (1995)

A novel surface receptor complex involved in inhibition of T-cell proliferation is described. Biochemical isolation revealed two non-covalently associated proteins of about M(r) 65,000 (p65) and 95,000 (p95). These polypeptides may be related. The p65 form is expressed after cellular activation and replication and is recognized by monoclonal antibody (mAb) 87.92.6 or reovirus hemagglutinin as unnatural ligands. The p95 species is associated with tyrosine kinase enzymatic activity. Receptor ligation results in rapid alteration of the phosphotyrosine content of cellular substrates, and this activity correlates with antiproliferative effects. The inhibition of proliferation is a time-dependent reversible arrest at the G1-S phase of the cell cycle. Activation through the T-cell receptor, protein kinase C, or addition of cytokines does not reverse the antiproliferative effect. This receptor complex may define novel features of T-cell proliferation.
Basic Concepts in Dose‐Finding (2006)

This chapter contains sections titled: Main concepts Main issues from a pharmaceutical point of view Statistical issues of dose-finding phase I trials Conclusion References
Electronic image storage utilizing a silicon dioxide target (1971)

A new electronic charge storage tube that utilizes storage targets fabricated by selective etching of thermally grown SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> films on silicon substrates is described. The completed targets have a storage density of 600 000 elements/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The flexibility of silicon technology allows targets to be designed with continuous readout time in the range of 3 to 30 min, with a corresponding erase time of 2 to 60 TV frames, respectively. Images may be stored for as long as 45 days without loss of resolution. The present limiting resolution is approximately 500 TV lines, making the tube capable of storing excellent television-quality images. The tube is capable of performing selective erase, write, and read.
<i>Aspergillus</i>and aspergillosis (1992)

Aspergillus and aspergillosis Get access J.C. Rhodes, J.C. Rhodes Search for other works by this author on: Oxford Academic PubMed Google Scholar H.E. Jensen, H.E. Jensen Search for other works by this author on: Oxford Academic PubMed Google Scholar A.M. Nilius, A.M. Nilius Search for other works by this author on: Oxford Academic PubMed Google Scholar C.R. Chitambar, C.R. Chitambar Search for other works by this author on: Oxford Academic PubMed Google Scholar S.G. Farmer, S.G. Farmer Search for other works by this author on: Oxford Academic PubMed Google Scholar R.G. Washburn, R.G. Washburn Search for other works by this author on: Oxford Academic PubMed Google Scholar P.E. Steele, P.E. Steele Search for other works by this author on: Oxford Academic PubMed Google Scholar T.W. Amlung T.W. Amlung Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Medical and Veterinary Mycology, Volume 30, Issue Supplement_1, January 1992, Pages 51–57, https://doi.org/10.1080/02681219280000761 Published: 01 January 1992
Salivary Flow Estimation- An Alternate And Non-Invasive Method (2017)

The objective of the study was to use a simple method for estimation of resting salivary flow rate with the help of paper chromatography. <strong>Materials and Methods: </strong>Sample size consisted of 180 participants from whom saliva was collected to determine the flow rate using chromatography filter paper, which was further compared with the salivary flow rate per minute using spitting method. Analyse comprised of 3 spots encompassing starch and potassium iodide per spot on filter paper. Based on the color response on the chromatography filter paper the salivary flow rate was estimated. <strong>Results: </strong>Pearson’s correlation test showed highly significant negative correlation when the salivary flow rate and the number of colored dots were compared. <strong>Conclusion: </strong>The method is accurate and can be of use in assessing the resting flow rate of saliva
Gadolinium(III)-Gold Nanorods for MRI and Photoacoustic Imaging Dual-Modality Detection of Macrophages in Atherosclerotic Inflammation (2013)

This new dual-modality nanoparticle approach has promise for enabling quantitative detection of macrophages in atherosclerotic plaques.
Privacy-preserving data aggregation without secure channel: Multivariate polynomial evaluation (2013)

Much research has been conducted to securely outsource multiple parties' data aggregation to an untrusted aggregator without disclosing each individual's privately owned data, or to enable multiple parties to jointly aggregate their data while preserving privacy. However, those works either require secure pair-wise communication channels or suffer from high complexity. In this paper, we consider how an external aggregator or multiple parties can learn some algebraic statistics (e.g., sum, product) over participants' privately owned data while preserving the data privacy. We assume all channels are subject to eavesdropping attacks, and all the communications throughout the aggregation are open to others. We propose several protocols that successfully guarantee data privacy under this weak assumption while limiting both the communication and computation complexity of each participant to a small constant.
Purification and properties of NADH-ferredoxinNAP reductase, a component of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816 (1990)

Cells of Pseudomonas sp. strain NCIB 9816, after growth with naphthalene or salicylate, contain a multicomponent enzyme system that oxidizes naphthalene to cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. We purified one of these components to homogeneity and found it to be an iron-sulfur flavoprotein that loses the flavin cofactor during purification. Dialysis against flavin adenine dinucleotide (FAD) showed that the enzyme bound 1 mol of FAD per mol of enzyme protein. The enzyme consisted of a single polypeptide with an apparent molecular weight of 36,300. The purified protein contained 1.8 g-atoms of iron and 2.0 g-atoms of acid-labile sulfur and showed absorption maxima at 278, 340, 420, and 460 nm, with a broad shoulder at 540 nm. The purified enzyme catalyzed the reduction of cytochrome c, dichlorophenolindophenol, Nitro Blue Tetrazolium, and ferricyanide. These activities were enhanced in the presence of added FAD. The ability of the enzyme to catalyze the reduction of the ferredoxin involved in naphthalene reduction and other electron acceptors indicates that it functions as an NAD(P)H-oxidoreductase in the naphthalene dioxygenase system. The results suggest that naphthalene dioxygenase requires two proteins with three redox groups to transfer electrons from NADH to the terminal oxygenase.
Activity scheduling in the dynamic multi-project setting (1999)

Article Free Access Share on Activity scheduling in the dynamic multi-project setting: choosing heuristics through deterministic simulation Author: Robert C. Ash Division of Business and Economics, Indiana University Southeast, 4201 Grant Line Road, New Albany, IN Division of Business and Economics, Indiana University Southeast, 4201 Grant Line Road, New Albany, INView Profile Authors Info & Claims WSC '99: Proceedings of the 31st conference on Winter simulation: Simulation---a bridge to the future - Volume 2December 1999 Pages 937–941https://doi.org/10.1145/324898.324933Published:01 December 1999Publication History 9citation430DownloadsMetricsTotal Citations9Total Downloads430Last 12 Months9Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Fetal rat lung maturation: initiation and modulation (1983)

The purpose of this study was to determine whether a rise in the level of circulating hormones is responsible for initiating fetal lung maturation. Explants of 13- to 20-day fetal rat lung were cultured in a constant chemically defined medium containing 0 or 1% serum. Growth, morphological maturation, and two biochemical markers of lung development, disaturated phosphatidylcholine (DSPC) synthesis and specific nuclear glucocorticoid binding, showed evidence of continuing development in culture. There is normally a marked increase in DSPC content and in the rate of choline incorporation into DSPC after 20 days gestation. Regardless of the gestational age of the fetal lungs used, there was a similar increase in culture at an equivalent gestational age of 20 days (e.g., 14-day lung after 6 days, 16-day lung after 4 days). Removal of 50 or 75% of the lung mesenchymal tissue at the initiation of the culture period did not prevent the increase in choline incorporation. Since the culture environment was constant and contained virtually no hormones, we conclude that the stimulus for the initiation of fetal lung maturation is most likely located in the lung tissue itself. The role of circulating hormones is probably later modulation of the maturational process.
Monitoring of intramuscular pressure. (1976)

Increased pressure within an osteofascial compartment may produce a compartmental syndrome, one of the principal causes of local circulatory compromise in traumatized extremities. In certain instances, monitoring of intracompartmental pressure may be a valuable adjunct in the clinical evaluation of patients at risk for this syndrome.
An Investigation of Two-Handed Manipulation and Related Techniques in Multi-touch Interaction (2010)

Multi-touch technique is a novel interactive technique that supports one finger or more to manipulate simultaneously. Thus, the bimanual interaction on the touch screen has been proved as a valuable input form with high degree of freedom (DOF). However, the drawbacks such as high error rate for target selection, hand fatigue and poor gesture extension critically limit the bimanual interaction on multi-touch environment. These drawbacks are mainly ascribed to the irrationality between hand input and software mapping, inconsistent gesture operation and immature gesture recognization techniques. In this paper, we investigate the related literatures about two-handed interaction techniques in multi-touch devices and discuss the drawbacks of current two-handed interaction techniques. Finally, we present some promising directions for future research.
Cancer Metabolism and Elevated O-GlcNAc in Oncogenic Signaling (2014)

O-Linked β-N-acetylglucosamine (O-GlcNAc) is a carbohydrate post-translational modification on hydroxyl groups of serine and/or threonine residues of cytosolic and nuclear proteins. Analogous to phosphorylation, O-GlcNAcylation plays crucial regulatory roles in cellular signaling. Recent work indicates that increased O-GlcNAcylation is a general feature of cancer and contributes to transformed phenotypes. In this minireview, we discuss how hyper-O-GlcNAcylation may be linked to various hallmarks of cancer, including cancer cell proliferation, survival, invasion, and metastasis; energy metabolism; and epigenetics. We also discuss potential therapeutic modulation of O-GlcNAc levels in cancer treatment.
SiC Products Formed by Slip Casting Method (2014)

The paper presents results of research designed to obtain a dense silicon carbide materials shaped by slip casting of aqueous suspensions. Aluminum oxide and yttrium oxide were used as sintering additives in a weight ratio of 3:2 in an amount of 10% by mass relative to the dry weight. The slip was electrostatically stabilized by adjusting pH . Measurement of the zeta potential as a function of pH and viscosity tests as a function of pH and volume fraction of the solid phase allowed for making selection of the suspension parameters, such as the solid volume loading (30%) and pH of ~ 8.5. Results of these investigations confirmed that it is possible to produce pseudoplastic slips suitable for slip casting. The increase in the strength of green bodies, allowing for their green processing, was obtained by addition of a commercial acrylic binder. SiC casts were sintered at 2050°C, which led to materials with high density and fine, homogeneous microstructure. The fracture toughness test revealed a positive effect of the sintering additives on K Ic of the material, increasing its value to approximately 5 MPa·m 1/2 .
CRC Codes for Short Control Frames in IEEE 802.11ah (2014)

In the new IEEE 802.11ah standard, a CRC code of 4 parity bits provides error detection for the SIG field of length 36 or 48 bits, giving rise to a significant performance penalty, which may be acceptable if there is an additional 32-bit Frame Check Sequence check on the payload in layer 2. However, in 802.11ah, there exist new Medium Access Control (MAC) control frames which are Null Data Packets (NDPs), which squeeze all critical information into the SIG field, and do not contain any payload at all. Hence, error checking is solely on CRC-4. These NDPs signal critical control functions in 802.11ah, and will affect MAC performance and energy consumption greatly if false positives occur. To achieve better performance, we propose that the number of parity bits be increased, and give the generator polynomials that achieve the improved performance. For the best performance-compatibility trade-off, an existing IEEE 802.11 CRC-8 generator can be used; the number of parity bits increased can be kept to 2, with a moderate performance gain, which can be achieved by a CRC-6 generator. Further, if the current generator and NDP control frame formats are fixed, but have some essential information bits to be received with high probability that they are correct, we may nest an inner CRC code to increase the error detection performance of the essential bits. For the inner code, an existing IEEE 802.11 CRC-8 generator can be used with a loss of 8 non-essential bits. We also propose an inner CRC-4 generator for a moderate performance gain and minimal loss of non-essential bits, and inner CRC-6 generators for enhanced performance.
Multimedia and Ultrafiltration for Reverse Osmosis Pretreatment Aboard Naval Vessels (2010)

The US Navy is interested in improving the pretreatment for shipboard Reverse Osmosis potable water systems. To investigate this problem, the Navy prepared a Task for the 2010 WERC (http://www.werc.net) competition. The research described in this paper was performed to compete in this WERC Task and ultimately received a 1st place award. Several technologies were considered as options for improving the current pretreatment process. Multi-media filtration followed by ultrafiltration was chosen as the most economical solution. This paper presents the final design for a full-scale shipboard system that incorporates multimedia filtration and ultrafiltration yet requires minimal space and optimal power usage. Although the work focuses on oceanic applications, inland water desalination plants can economically use the technology. The proposed process provides an annual incremental savings, including reduced maintenance and filter usage, of $17,000 over the current process, resulting in a payback period of 14 years. However, as savings are highly dependent on the replacement frequency of all components, ships operating in coastal waters may realize greater savings of up to $47,000 annually, thus reducing the payback period to 5 years.
Design of a CMOS APD array for a 3-D camera based on the time of flight distance measurement (2010)

This paper presents the design of an array of avalanche photodiodes (APD) in standard CMOS technology for a 3-D camera. The distance measurement is based on the time of flight principle, more precisely on the phase-shift measurement method. The pixel is operated in permanent sinusoidal regime based on optoelectronic mixing technique. Circuit simulations allowed the architecture validation and the global performances to be predicted. Millimetric measurement resolution can be expected for a distance range of 18 m.