gebhart/patrepeval huggingface dataset:
EXTRACTION, IDENTIFICATION, FORMULATION AND EVALUATION OF PIPERINE IN ALGINATE BEADS. (2009)

Piperine {[1-5-(1, 3)-benzodioxol-5-yl)-1-oxo-2, 4-pentadienyl]-piperidine},an alkaloid responsible for the pungency of black pepper & long pepper. Systemic pharmacological studies on piperine have revealed that this compound elicited diverse pharmacological activities; analgesic, anti-pyretic, anti-inflammatory, anti-convulsant & CNS-depressant activities. Piperine was isolated from Piper nigrum Linn. (Piperaceae) and identified by TLC. Piperine was fabricated into alginate beads using sodium alignate. The main aim of this study was to demonstrate the sustained release of piperine from alginate beads by in vitro evaluation. The drug release studies were showed that the alginate beads sustained the release of the drug with % drug released in hours.
Organic Semiconductors: Purification and Crystal Growth (1989)

Abstract First, a brief overview is given on literature dealing with purification, purity assessment, and crystal growth methods which are applicable to organic photoconductors and semiconductors under the aspect of the required high purity. Then some recent examples are presented of purification, material handling and crystal growth of some selected compounds (perylene, naphthalene, phenanthrene, TTF:chloranil and bipyridylammonium: (TCNQ)2). Progress is reflected in greatly improved electrical properties of these materials which allowed detection of entirely new features, such as enhanced charge carrier scattering at phase transitions and non-Ohmic transport. Finally, some advanced crystal growth techniques are presented: Czochralski growth of organic molecular crystals under high purity conditions, flux growth of donor:acceptor crystals from a melt solution in one of the two components, oriented epitaxial growth "organic on organic" and epitaxial growth of organic materials on inorganic substrates.
Role of Connective Tissue Growth Factor in Mediating Hypertrophy of Human Proximal Tubular Cells Induced by Angiotensin II (2003)

Our data are the first to clearly demonstrate that CTGF might be an important mediator of Ang II-induced renal hypertrophy, which suggests that inhibiting the production of CTGF might be the new strategy in early prevention of renal fibrosis.
DG Integrated Approach for Service Restoration Under Cold Load Pickup (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The additional power demand caused by cold load pickup (CLPU) condition restricts the simultaneous restoration of all the loads of a network due to excessive loading on the network elements and violation of limits. Therefore, step-by-step restoration is the most adopted approach. However, it requires long time for the complete restoration. The main cause of CLPU problem is the loss of diversity amongst the loads which causes the enduring phase of CLPU condition. The conservation of load diversity reduces the demand during restoration. In the proposed approach, the diversity is conserved by using distributed generation (DG) for quick restoration and the reduction of additional power demand caused by CLPU condition. The capacity required for DG is evaluated on the basis of the required additional power demand and the load-diversity preserved. The proposed approach utilizes the genetic algorithm for determination of the optimal size and location of the required DG. The approach is demonstrated on a 33-bus, 12.66-kV primary distribution network. </para>
Applause Productions. <i>Italian Poets at Spoleto.</i> The World’s Great Poets. Reading at the Festival of Two Worlds, Spoleto, Italy (1970)

"Applause Productions. Italian Poets at Spoleto. The World’s Great Poets. Reading at the Festival of Two Worlds, Spoleto, Italy." Canadian Modern Language Review, 26(3), p. 83
The <i>Drosophila Ras2</i> and <i>Rop</i> gene pair: a dual homology with a yeast <i>Ras</i>-like gene and a suppressor of its loss-of-function phenotype (1993)

The promoter of the Drosophila melanogaster Ras2 gene is bidirectional, regulating an additional gene oriented in the opposite polarity. The two divergently transcribed genes are only 93 bases apart and deletion analysis proved that common cis-acting elements within this promoter region are required for the transcriptional activity of both genes. We cloned the gene paired with Ras2 in the bidirectional promoter and isolated cDNAs corresponding to its mRNA. The Ras opposite (Rop) gene encodes for a 68 x 10(3) M(r) protein which shares sequence homology with the members of a novel Saccharomyces cerevisiae gene family, including the SLY1, SEC1 and VPS33 (SLP1) genes, all of which are involved in vesicle trafficking among yeast cellular compartments. A highly conserved motif in this family is also found in beta-COP, a coat protein isolated from rat Golgi-bound nonclathrin vesicles. Thus, the Rop protein may be a component of one of the vesicle trafficking pathways in Drosophila cells. The Rop gene expression during embryogenesis is restricted to the central nervous system (CNS) and the garland cells, a small group of nephrocytes that takes up waste materials from the haemolymph by endocytosis. Ras2 is also expressed in the embryonic garland cells. In postembryonic stages, the two genes are co-expressed in the larval salivary glands and the central nervous system, and in the adult CNS and reproductive systems. Interestingly, the S. cerevisiae SLY1-20 allele is a suppressor of the loss of the YPT1 gene, a ras-like gene implicated in vesicle translocation, suggesting that the two genes may interact with one another. Since Sec1p and beta-COP may also interact with small GTP-binding proteins of the ras superfamily, it is conceivable that the Rop and Ras2 gene products are not just co-expressed in common tissues, but may also functionally interact with one another in these tissues.
Adverse effects of antiepileptic drugs: a brief overview of important issues (2010)

All medications have some adverse effects, ranging from mild to acute and serious or chronic. Antiepileptic drugs (AEDs) differ in the type and severity of adverse effects, mostly during initiation and early treatment. Some concerns are related to pharmacodynamic tolerance often affected by the dose and rate of initiation, while other concerns are idiosyncratic responses to the drug (rare and not predictable). Thus, lack of tolerability is a common reason for changing medication, quantified in studies as treatment retention. Although adverse effects can occur with all AEDs, and CNS effects are most prevalent, selected effects are hallmarks of specific drugs. The failure of an AED regimen may be the result of unacceptable adverse effects (intolerance), inadequate seizure control (inefficacy) or a combination of both. Although some diminution in adverse effects is typical when a drug is used in monotherapy, the potential for most issues remains if they are dose-related or idiosyncratic. This article describes three categories of prevalent adverse effects (CNS, behavioral and general medical issues) comparing profiles of second- and third-generation AEDs.
Smallest diameter carbon nanotubes (2000)

Mass-selected carbon ion beam deposition (MSIBD) was used to demonstrate that the diameter of a carbon nanotube could be as small as 0.4 nm, the theoretical limit predicted but never experimentally reached so far. The deposition was performed at an elevated temperature much lower than the high temperatures (800–1000 °C) needed for deposition of carbon nanotubes by conventional methods. High-resolution transmission electron microscopy showed that the combination of the stress induced by the ion impact and the C migration at the temperature applied formed graphitic sheets with their normal (c axis) parallel to the surface of the silicon substrate. Some sheets closed to form multiwall nanotubes. The smallest diameter of the innermost tube was found to be 0.4 nm. The novel use of MSIBD (a pure method, catalyst free, low deposition temperature, easily applied to large surfaces without surface pretreatment capable of pattern-writing) may significantly advance the carbon nanostructure technology.
Structure and hydrolysis of p-(2-oxo-1-pyrrolidinyl)- benzenesulfonic acid (1987)

With the aid of vibrational and PMR spectra of p-(2-oso-1-pyrrolidinyl)benzenesulfonic acid it was shown that in the solid state it exists as an O-protonated dipolar ion in which the protonated amide cation and sulfonate ion are intermolecularly linked by a very strong hydrogen bond. In concentrated hydrochloric acid the dipolar ion is an intermediate link in the chain of processes in the hydrolysis of the amide bond of the lactam ring.
Intersheet rearrangement of polypeptides during nucleation of β-sheet aggregates (2005)

Many neurodegenerative diseases are characterized by the accumulation of amyloid fibers in the brain, which can occur when a protein misfolds into an extended beta-sheet conformation. The nucleation of these beta-sheet aggregates is of particular interest, not only because it is the rate-determining step toward fiber formation but also because early, soluble aggregate species may be the cytotoxic entities in many diseases. In the case of the prion peptide H1 (residues 109-122 of the prion protein) stable amyloid fibers form only after the beta-strands of the peptide have adopted their equilibrium antiparallel beta-sheet configuration with residue 117 in register across all strands. In this article, we present the kinetic details of the realignment of these beta-strands from their fastformed nonequilibrium structure, which has no regular register of the strands, into the more ordered beta-sheets capable of aggregating into stable fibers. This process is likely the nucleating step toward the formation of stable fibers. Isotope-edited IR spectroscopy is used to monitor the alignment of the beta-strands by the introduction of a (13)C-labeled carbonyl at residue 117. Nonexponential kinetics is observed, with a complex dependence on concentration. The results are consistent with a mechanism in which the beta-sheet realigns by both the repeated detachment and annealing of strands in solution and reptation of polypeptide strands within an aggregate.
Ball bond characterization: an intensive analysis on ball size and shear test results and applicability to existing standards (2002)

To date, the American Society for Testing and Materials (ASTM) standard is the criterion widely used in the semiconductor industry wherein the minimum ball shear test requirement is based on the wire diameter. Lately, another standard was introduced in the business, the Automotive Electronic Council (AEC) standard, which prescribed a minimum shear reading for a corresponding ball diameter produced. In line with this, this paper presents the characterization made on attributes which could affect the ball formation and shear test results. Moreover, a study was conducted to determine the running capability on ball diameter and ball shear test readings with respect to ASTM and AEC standards.
Porphyrin production and regulation in different Propionibacterium acnes lineages contribute to acne vulgaris pathogenesis (2017)

Propionibacterium acnes is a dominant human skin commensal. It has been implicated in acne pathogenesis, but its role remains unclear. Recent metagenomic studies have revealed that certain P. acnes strains are highly associated with acne, while some others are associated with healthy skin. Little information exists about P. acnes strain-level differences beyond the genomic differences. In this study, I revealed that acne-associated type IA P. acnes strains produced significantly higher levels of porphyrins (a metabolite important in acne development) than health-associated strains (type II). Strains of type IA-1 and type IA-2 produced similar levels of porphyrins. Moreover, porphyrin production in these P. acnes strains is modulated by vitamin B12. On the other hand, health-associated type II strains produced low levels of porphyrins and did not respond to vitamin B12. Strains from other lineages (type IB and type III) have lower levels of porphyrin production and porphyrin levels were not modulated by vitamin B12. Using small molecule substrates and inhibitors, I demonstrated that porphyrin biosynthesis was modulated at the metabolic level in type IA strains. By comparing the porphyrin operons of different strains, I identified a repressor gene (deoR) of porphyrin biosynthesis that was encoded in all health-associated P. acnes type II strains, types IB-3, IC, and III strains, but not in acne-associated type IA strains. The expression of deoR suggests regulation of porphyrin production at the transcriptional level in health-associated strains. Other skin propionibacteria, Propionibacterium granulosum, Propionibacterium avidum, and Propionibacterium humerusii, produced little or no porphyrin, and were not regulated by vitamin B12. Additionally, I developed an assay using mass spectrometry to analyze porphyrin levels in skin samples. The findings from my study provide a potential molecular explanation for the different contributions of P. acnes strains to skin health and disease, and support the role of vitamin B12 in acne pathogenesis in a subset of the population. This study emphasizes the importance of understanding the role of the commensal microbial community in health and disease at the strain level, and suggests potential utility of health-associated P. acnes strains in acne treatment.
Structural, optical and elastic properties of zinc oxide soda lime silicate glass (2011)

So far, most research had been done to understand the properties and advantages of soda lime silicate (SLS) glass compare to others glass and also to improve their quality. Addition of oxide into the glass system had been a topic of research for nearly half century, but many questions still remain unanswered concerning to the effect of the addition of some oxide to the properties and the structure changes of the glass. In this research, fabrication of a series of (ZnO)x(SLS)1-x glasses with weight percentage x from 0.05 to 0.40 were carried out by the melting and quenching technique. The chemical composition of the (ZnO)x(SLS)1-x glasses were determined using Inductive Couple Plasma (ICP) and Energy Dispersive X-ray Fluorescence (EDXRF). The amorphous structure of the glass samples were confirmed using X-ray diffraction (XRD) measurement. The glass density was measured by using Archimedes’ principle. The densities of the glass sample were increased with the addition of ZnO. The molar volume of the glass samples shows a same trend with the density of the glasses which is increased with the increased of ZnO content. Their physical properties such as elastic properties were determined at room temperature by using non-destructive test; the digital signal processing technique of Matec DSP MBS 8000. The experimental data of wave velocities and densities were then used to determine the longitudinal modulus, shear modulus, Young modulus, bulk modulus, Poisson’s ratio, fractal bond connectivity and Micro-hardness in each series of (ZnO)x(SLS)1-x glass system. It was found that the longitudinal modulus, shear modulus, Young modulus and bulk modulus decreased with the addition of ZnO in the SLS glasses. These elastic properties of glasses were found closely related to the strength of the glass structure. The values of the elastic properties had been compared with the Rocherulle’s model and this model shows a same trend which is the values of the longitudinal modulus, shear modulus, Young modulus and bulk modulus of the glass samples decreased with the addition of ZnO. The bonding in the (ZnO)x(SLS)1-x glasses were measured using IR Spectroscopy. The shift band of IR spectroscopy must be occurs due to the addition of ZnO, which means increase the non-bridging oxygens (NBOs) in the glass structure and resulting the structural of the glass samples become weaker. The optical properties of the (ZnO)x(SLS)1-x glass system were measured using UV-Visible spectroscopy. The values of the optical band gap decreased with the addition of ZnO in the SLS glass system
An improved primal simplex variant for pure processing networks (1989)

In processing networks, ordinary network constraints are supplemented by proportional flow restrictions on arcs entering or leaving some nodes. This paper describes a new primal partitioning algorithm for solving pure processing networks using a working basis of variable dimension. In testing against MPSX/370 on a class of randomly generated problems, a FORTRAN implementation of this algorithm was found to be an order-of-magnitude faster. Besides indicating the use of our methods in stand-alone fashion, the computational results also demonstrate the desirability of using these methods as a high-level module in a mathematical programming system.
Mechanisms of Salt Tolerance in Nonhalophytes (1980)

Crop loss due to soil salinization is an increasing threat to agriculture worldwide. This review provides an overview of cellular and physiological mechanisms in plant responses to salt. We place cellular responses in a time- and tissue-dependent context ...Read More
Treatment of cotton and wool fabrics with different nanoparticles for multifunctional properties (2021)

ZnO, TiO2, and CuO nanoparticles were immobilized onto the cotton and wool fabrics at room temperature. The antimicrobial activity of dyed cotton and wool fabrics with reactive dye against S-aureus, E-coli, and C-candida were measured by the optical density method. It was observed that the killing of bacteria and the bacterial cell damage were harmed efficiently. The effect of pre-treatment of cotton and wool fabrics with different NPs metal oxides on the color strength of dyed fabrics was studied. Color strength (K/S) and colorimetric data (L*, a*, and b*) were measured at specific λmax. Besides, washing, rubbing, perspiration, and lightfastness of dyed cotton and wool fabrics were determined. UV blocking and self-cleaning of the treated fabrics were measured accordingly. The obtained results of the pre-treated fabrics with ZnO, TiO2, and CuO nanoparticles would support the current research outputs as a potential production of protective textile.
Applying priorities to memory allocation (2002)

A novel approach of applying priorities to memory allocation is presented and it is shown how this can be used to enhance the robustness of real-time applications. The proposed mechanisms can also be used to increase performance of systems with automatic memory management by limiting the amount of garbage collection work.A way of introducing priorities for memory allocation in a Java system without making any changes to the syntax of the language is proposed and this has been implemented in an experimental Java virtual machine and verified in an automatic control application.
Structural and functional domains in human tumour necrosis factors (1991)

Human tumour necrosis factors (hTNFs) alpha and beta are related pleiotropic cytokines which share many activities and compete with each other for binding to two receptor components on many cell types. Although structural and biological data indicate that the active form of hTNF-alpha may be a symmetrical trimer, the manner in which hTNFs interact with their receptors to trigger a myriad of cell type-dependent responses is not clear. A combination of chemical modification, epitope mapping and site-directed mutagenesis approaches suggest that at least four distinct peptide sequences are important for the biological activity of hTNF-alpha. In particular, certain peptide sequences between amino acid positions 11 and 35 in hTNF-alpha appear to be critical for receptor binding and triggering biological responses. The recent cloning of the two hTNF-alpha/beta receptors opens the way for precise mapping of the functional domains in hTNFs.
The EF‐1α promoter maintains high‐level transgene expression from episomal vectors in transfected CHO‐K1 cells (2017)

In our previous study, we demonstrated that episomal vectors based on the characteristic sequence of matrix attachment regions (MARs) and containing the cytomegalovirus (CMV) promoter allow transgenes to be maintained episomally in Chinese hamster ovary (CHO) cells. However, the transgene expression was unstable and the number of copies was low. In this study, we focused on enhancers, various promoters and promoter variants that could improve the transgene expression stability, expression magnitude (level) and the copy number of a MAR-based episomal vector in CHO-K1 cells. In comparison with the CMV promoter, the eukaryotic translation elongation factor 1 α (EF-1α, gene symbol EEF1A1) promoter increased the transfection efficiency, the transgene expression, the proportion of expression-positive clones and the copy number of the episomal vector in long-term culture. By contrast, no significant positive effects were observed with an enhancer, CMV promoter variants or CAG promoter in the episomal vector in long-term culture. Moreover, the high-expression clones harbouring the EF-1α promoter tended to be more stable in long-term culture, even in the absence of selection pressure. According to these findings, we concluded that the EF-1α promoter is a potent regulatory sequence for episomal vectors because it maintains high transgene expression, transgene stability and copy number. These results provide valuable information on improvement of transgene stability and the copy number of episomal vectors.
AESTHETICS AND CONCRETE SEGMENTAL BRIDGES. BRIDGE AESTHETICS AROUND THE WORLD (1991)

This paper begins with a brief historical review of notable arch bridges. These bridges were used for long spans before the introduction of prestressed concrete and segmental methods, which are the main subject of this paper. The majority of structures built segmentally have been box girder bridges, covering a large range of span lengths with many different shapes and functions. Following a look at some noteworthy box girder bridges, attention is focused on more specific areas such as long-span bridges, bridges over large bodies of water, structures built in environmentally sensitive areas, urban viaducts, and concrete cable-stayed bridges.
John Miller (1957)

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Epithelial stem cells: An epigenetic and wnt‐centric perspective (2010)

Epithelial stem cells, such as those present in mammalian skin, intestine, or mammary gland, are tissue stem cells capable of both long-term self-renewal and multi-lineage differentiation. Here we review studies implicating epigenetic control mechanisms in mammalian epithelial stem cell development and homeostasis. We also provide an update of recent progresses in the involvement of canonical Wnt signaling and note an interesting link between the Wnt pathway and chromatin regulation in epithelial stem cells. We anticipate that epigenetic and epigenomic studies of these cells will increase exponentially in the near future.
Uploading from Digital Cameras (2014)

Again, you could use the Desktop to do this like you would in prior versions of Windows and the processes are pretty similar, but it is simplest to work from the Start Screen. To get started, plug in your camera using the USB cable. As soon as you plug in for the first time, a message will appear on the top right of the screen asking you what to do with the device you have just plugged in. Click on it.