gebhart/patrepeval huggingface dataset:
Purification, Molecular Cloning, and Functional Expression of the Human Nicodinamide-Adenine Dinucleotide Phosphate-Regulated Thyroid Hormone-Binding Protein (1997)

The kidney and several other thyroid hormone-responsive tissues contain a NADP-regulated thyroid hormone (TH)-binding protein (THBP), with an apparent molecular mass of 36 kDa on SDS-PAGE, responsible for most of the intracellular high-affinity T3 and T4 binding. THBP was purified to homogeneity from human kidney cytosol and used to generate proteolytic peptides. Microsequencing of four peptides revealed identity to amino acid sequences deduced from a human cDNA homolog to a cDNA encoding kangaroo mu-crystallin. This protein is a major structural kangaroo lens protein with no known function in other species. A full-sized cDNA (TH5.9) was isolated by 5'- and 3'-rapid amplification of cDNA ends using a human brain cDNA library and gene-specific PCR primers, confirming identity to the previously cloned human cDNA. The TH5.9 cDNA encodes a 314-residue protein (theoretical mol wt = 33,775) with significant homologies (40 to 60%) with two bacterial enzymes: lysine cyclodeaminase and ornithine cyclodeaminase. The TH5.9 cDNA was expressed in Escherichia coli as a glutathione S-transferase (GST) fusion protein. Purified GST fusion protein, but not GST, bound T3 specifically with high affinity [dissociation constant (Kd) = 0.5 nM] in the presence of NADPH, and was labeled by UV-driven cross-linking of underivatized [(125)I]T3. T3 binding and photoaffinity labeling of GST fusion protein were activated by NADPH [activation constant (K[act]) = 10(-8) M], but not by NADH. The expressed protein displays the appropriate binding properties, indicating that TH5.9 cDNA encodes the NADP-regulated THBP characterized in human tissues.
Psychometric properties of the Community Mental Health Team effectiveness questionnaire (CMHTEQ) (2001)

The Community Mental Health Team effectiveness questionnaire (CMHTEQ) is a 27-item measure of Community Mental Health Team (CMHT) effectiveness for completion by team members. It was constructed following a stakeholder conference representing the following constituencies: clinicians, users and carers, mental health researchers, policy makers and managers. We present a psychometric analysis of the CMHTEQ, based on the responses of 1450 (response rate: 75%)CMHT staff of a sample of 113 CMHTs recruited from all Trusts providing community mental health care across four English NHS Regions. Three factors emerged from an exploratory analysis of 50% of the data, upheld by a confirmatory analysis of the remaining data: meeting external requirements; internal team processes; evidence and feedback. Factor scales exhibited acceptable internal reliabilities. The CMHTEQ meets the need for a measure of the effectiveness of CMHTs, as perceived by their members, for use in research studies of the environment and effectiveness of mental health care, and by service managers or CMHTs seeking to monitor or track performance change over time.
3D IMAGING OF INDIVIDUAL PARTICLES: A REVIEW (2012)

In recent years, impressive progress has been made in digital imaging and in particular in three dimensional visualisation and analysis of objects. This paper reviews the most recent literature on three dimensional imaging with a special attention to particulate systems analysis. After an introduction recalling some important concepts in spatial sampling and digital imaging, the paper reviews a series of techniques with a clear distinction between the surfometric and volumetric principles. The literature review is as broad as possible covering materials science as well as biology while keeping an eye on emerging technologies in optics and physics. The paper should be of interest to any scientist trying to picture particles in 3D with the best possible resolution for accurate size and shape estimation. Though techniques are adequate for nanoscopic and microscopic particles, no special size limit has been considered while compiling the review.
Tetanus. (1986)

Tetanus is produced by the action of the potent neurotoxin, tetanospasmin, which is elaborated during the growth of Clostridium tetani. The objectives of management of tetanus are to provide supportive care until the tetanospasmin that is fixed in tissue has been metabolized, to neutralize circulating toxin, and to remove the source of tetanospasmin. This disease, which is frequently fatal, is prevented by immunization.
A study of integration methods of aerial imagery and LIDAR data for a high level of automation in 3D building reconstruction (2003)

This paper describes integration methods to increase the level of automation in building reconstruction. Aerial imagery has been used as a major source in mapping fields and, in recent years, LIDAR data became popular as another type of mapping resources. Regarding to their performances, aerial imagery has abilities to delineate object boundaries but leaves many missing parts of boundaries during feature extraction. LIDAR data provide direct information about heights of object surfaces but have limitation for boundary localization. Efficient methods using complementary characteristics of two sensors are described to generate hypotheses of building boundaries and localize the object features. Tree structures for grid contours of LIDAR data are used for interpretation of contours. Buildings are recognized by analyzing the contour trees and modeled with surface patches with LIDAR data. Hypotheses of building models are generated as combination of wing models and verified by assessing the consistency between the corresponding data sets. Experiments using aerial imagery and laser data are presented. Our approach shows that the building boundaries are successfully recognized through our contour analysis approach and the inference from contours and our modeling method using wing model increase the level of automation in hypothesis generation/verification steps.
Reduction in the expression and action of transforming growth factor beta 1 on lactotropes during estrogen-induced tumorigenesis in the anterior pituitary. (1995)

We have previously shown that transforming growth factor beta 1 (TGF-beta 1) receptor and TGF-beta type II receptor (T beta R-II) are produced in lactotropes, and that TGF-beta 1 inhibits the growth of these anterior pituitary cells by an autocrine mechanism. To study the changes of the expression and function of this growth factor during tumorigenesis, we have measured the levels of TGF-beta 1 and T beta R-II mRNAs and proteins in the normal and tumor anterior pituitary cells in vivo and in vitro and have compared the cell growth responses to TGF-beta 1 in normal and tumor pituitary cells in vitro. Treatment with estradiol-17 beta for 1, 2, 4, and 8 weeks caused a time-dependent increase in pituitary protein, prolactin, and prolactin mRNA levels and in plasma prolactin levels, suggesting that estrogen enhanced lactotropic proliferation in anterior pituitary glands. The levels of TGF-beta 1 protein and mRNA in anterior pituitary tissues were reduced over time after estrogen treatment during the development of pituitary tumors. The mRNA and protein levels of T beta R-II decreased markedly during the development of pituitary tumors. In addition, two transformed lactotropes, GH3 and PR1 cell lines, showed markedly reduced levels of TGF-beta 1 as well as T beta R-II mRNA. Comparison of the antiproliferative effects of TGF-beta in transformed and normal lactotropes in cultures revealed that the sensitivity of GH3 cells is reduced, and that PR1 cells are virtually resistant to TGF-beta 1.(ABSTRACT TRUNCATED AT 250 WORDS)
한자(漢字), 한문교육(漢文敎育) 현장실천(現場實踐) 지향적(指向的) 교수(敎授)-학습(學習) 방법(方法) 연구(硏究)의 현황(現況)과 성과(成果) (2014)

이 글의 검토 대상은 ‘한자·한문교육 현장실천 교수-학습 방법’이다. 그간의 연구현황 및 성과를 돌아보고 이를 바탕으로 향후의 과제점검을 목적으로 한다. 연구현황을 확인하기 위한 자료는 한국한자한문교육학회지 『한자한문교육』과 한 국한문교육학회지 『한문교육연구』이다. 교수-학습 방법에 대해서는 한국한문교 육학회 창립 30주년기념 학술대회(2011)와 한국한문교육연구총서 『한문과 교수-학습 방법론』(2012)에서 그간의 연구실적을 정리하였다. 연구의 현황과 성과는 ‘한자’, ‘어휘’, ‘한시’, ‘산문’으로 분류하고, 이에 속하지 않는 것은 ‘일반자료’로 모아서 정리 하였다. 또한 ‘매체 활용교육’ 관련 자료도 별 도로 언급하였다. 이상을 검토해 본 바 다음과 같은 몇 가지 과제가 확인되었다. 첫째, 한시·산문 관련 교수-학습 방법 연구 성과가 부족하다. 이 부분에 대해 서는 학회차원에서 기획주제로 다루어 이에 대한 연구의 활성화를 도모할 필요가 있다. 둘째, ‘수업모형’이나 ‘교수-학습 방법의 체계화’와 관련한 연구가 활발해져 서 연구성과가 교육과정에 더 많이 축적되어야 하겠다. 현장교사들에게 있어 교육 과정은 직접적인 수업안내 지침이기 때문이다. 셋째, 교수-학습 방법과 관련하여 이론연구보다 현장실천 연구실적이 상대적으로 빈약하다. 이의 해결을 위해 전공 교사들의 학회 참여 유도가 필요하리라 본다. 교사 개인이 지닌 우수 지도방안을 공유할 수 있도록 하기 위해서이다.
Internet security, and firewalls protection on the internet (2002)

Looks at various aspects of internet security, and firewalls protection on the internet. In particular the author looks at the business dilemma; security risks; internet security; inter-company security; intranet security; integrated security; firewall concepts; firewall limitations and functions; Digital's firewall family; layered security; encrypted tunneling; other security issues; and future trends.
Open Calendar Sharing and Scheduling with CalDAV (2005)

Building on a decade of work on calendar standards, the CalDAV protocol promises to unlock the potential of widespread calendar interoperability. It permits calendar sharing over the Web and reduces the coordination cost of scheduling meetings across and within organizational boundaries. The protocol extends the Web Distributed Authoring and Versioning (WebDAV) protocol-itself, a simple extension of HTTP- to provide services for calendar maintenance, queries, event scheduling, and security.
Electrical and mechanical properties of conducting carbon black filled composites based on rubber and rubber blends (1999)

The electrical and mechanical properties of new conductive rubber composites based on ethylene–propylene–diene rubber, acrylonitrile butadiene rubber (NBR), and their 50/50 (weight ratio) blend filled with conductive black were investigated. The threshold concentrations for achieving high conductivity are explained on the basis of the viscosity of the rubber. The electrical conductivity increases with the increase in temperature whereas the activation energy of conduction decreases with an increase in filler loading and NBR concentration in the composites. The electrical hysteresis and electrical set are observed during the heating–cooling cycle, which is mainly due to some kind of irreversible change occurring in the conductive networks during heating. The mechanisms of conduction in these systems are discussed in the light of different theories. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 71: 887–895, 1999
Achievability proof of some multiuser channel coding theorems using backward decoding (1989)

New and simpler achievability proofs that are based on the backward decoding technique are presented for the well-known coding theorems for the multiple-access channel (MAC) with perfect feedback and the degraded relay channel. A class of MACs with different generalized feedback signals is also considered, and achievable-rate regions that are larger than those previously presented in the literature are established.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Reexamination of the Role of Employer Motive Under Sections 8(a)(1) and 8(a)(3) of the National Labor Relations Act (1982)

The question of the role of employer motive in analysis of the unfair labor practices defined by Sections 8(a)(1) and (3) of the National Labor Relations Act has troubled the National Labor Relations Board and the courts from time of the enactment of that legislation. Despite repeated efforts by the Supreme Court to authoritatively define that role and repeated efforts by academics to advise the Court in the task, motive's function remains confused—the subject of diverse viewpoints compromised in the cases by an analysis which submerges fundamental isssues in the language of procedural burdens of proof. The Board, which had long adhered to the view that an employer motivated even "in part" by an "anti-union animus" in discharging an employee violated the Act, recently succumbed to repeated First Circuit criticism of that position and adopted, in Wright Line, a "but for" causation test of employer motive tied explicitly to an allocation of the burden of proof and derived from the Supreme Court's similar test in the constitutional arena. Wright Line presents anew old dilemmas concerning the meaning and efficacy of motive as a touchstone for analysis of an employer's conduct in the context of Sections 8(a)(1) and (3) unfair labor practices. This Article will attempt a reexamination of these questions, using Wright Line's adoption of the sine qua non causation test as both the occasion and vehicle for that reexamination.
Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells. (1991)

Nerve growth factor (NGF) plays a critical role in the development and survival of neurons in the peripheral nervous system. Following treatment with NGF but not epidermal growth factor, rat pheochromocytoma (PC12) cells undergo neural differentiation. We have cloned a nervous system-specific mRNA, NGF33.1, that is rapidly and relatively selectively induced by treatment of PC12 cells with NGF and basic fibroblast growth factor in comparison with epidermal growth factor. Analysis of the nucleic acid and predicted amino acid sequences of the NGF33.1 cDNA clone suggested that this clone corresponded to the NGF-inducible mRNA called VGF (A. Levi, J. D. Eldridge, and B. M. Paterson, Science 229:393-395, 1985; R. Possenti, J. D. Eldridge, B. M. Paterson, A. Grasso, and A. Levi, EMBO J. 8:2217-2223, 1989). We have used the NGF33.1 cDNA clone to isolate and characterize the VGF gene, and in this paper we report the complete sequence of the VGF gene, including 853 bases of 5' flank revealed TATAA and CCAAT elements, several GC boxes, and a consensus cyclic AMP response element-binding protein binding site. The VGF promoter contains sequences homologous to other NGF-inducible, neuronal promoters. We further show that VGF mRNA is induced in PC12 cells to a greater extent by depolarization and by phorbol-12-myristate-13-acetate treatment than by 8-bromo-cyclic AMP treatment. By Northern (RNA) and RNase protection analysis, VGF mRNA is detectable in embryonic and postnatal central and peripheral nervous tissues but not in a number of nonneural tissues. In the cascade of events which ultimately leads to the neural differentiation of NGF-treated PC12 cells, the VGF gene encodes the most rapidly and selectively regulated, nervous-system specific mRNA yet identified.
Endotracheal Tubes: Old and New (2014)

The development and evolution of the endotracheal tube (ETT) have been closely related to advances in surgery and anesthesia. Modifications were made to accomplish many tasks, including minimizing gross aspiration, isolating a lung, providing a clear facial surgical field during general anesthesia, monitoring laryngeal nerve damage during surgery, preventing airway fires during laser surgery, and administering medications. In critical care management, ventilator-associated pneumonia (VAP) is a major concern, as it is associated with increased morbidity, mortality, and cost. It is increasingly appreciated that the ETT itself is a primary causative risk for developing VAP. Unfortunately, contaminated oral and gastric secretions leak down past the inflated ETT cuff into the lung. Bacteria can also grow within the ETT in biofilm and re-enter the lung. Modifications to the ETT that attempt to prevent bacteria from entering around the ETT include maintaining an adequate cuff pressure against the tracheal wall, changing the material and shape of the cuff, and aspirating the secretions that sit above the cuff. Attempts to reduce bacterial entry through the tube include antimicrobial coating of the ETT and mechanically scraping the biofilm from within the ETT. Studies evaluating the effectiveness of these modifications and techniques demonstrate mixed results, and clear recommendations for which modification should be implemented are weak.
Analysis of the bimodal chemiluminescence pattern stimulated in human neutrophils by chemotactic factors (1983)

Chemotactic factors, which are important in attracting neutrophils to inflammatory sites, have also been shown to stimulate oxidative metabolism, resulting in increased chemiluminescence and release of superoxide anion (O2-). We observed a unique bimodal chemiluminescence pattern upon stimulation with either the complement-derived factor C5a or formyl-methionyl-leucyl-phenylalanine. A sharp peak of activity occurred within 1 to 2 min, and a second more extended peak was seen between 3 and 6 min. Enhancement of both peaks occurred when the cells were pretreated with cytochalasin B. Expression of both peaks was found to be related to cell density, and expression of the second peak was not dependent upon extracellular metabolites released during the first peak. Cells preincubated in luminol and then thoroughly washed responded with only a single peak coincident with the second peak. Together these findings indicate that the first peak is extracellular in origin, whereas the second peak is cell associated. Studies with scavengers of oxygen intermediates and inhibitors of myeloperoxidase for the oxidation of luminol, which may occur in part through the formation of HOCl as well as through a non-HOCl-mediated mechanism. Evidence for a non-HOCl-mediated mechanism comes from experiments in which luminol, myeloperoxidase, and O2- generated by xanthine-xanthine oxidase produce luminescence in the absence of chloride ion. These studies provide further insight into the sequence of events which occur during the stimulation of neutrophils with chemotactic factors and the nature of neutrophil chemiluminescence.
Performance of the enhanced Abbott AxSYM Cardiac Troponin I reagent in patients with heterophilic antibodies (2000)

The presence of heterophilic antibodies in the serum of a small subpopulation of individuals continues to cause false results for modern-day immunoassays. In order to determine the frequency of heterophilic antibody (HA)-related false positives within our population of positive cardiac troponin I (cTnI) patients, we assayed 200 samples using the original in-house cTnI assay (Abbott AxSYM) and the Bayer ACS:180 cTnI, which we had previously observed to be more effective at blocking HA interference. Four samples were identified as false positives based on discordant results between the two assays, as well as the correction of the false positives by treatment of the samples with heterophilic antibody blocking reagent (HBR). An 'enhanced' version of the AxSYM cTnI reagent was designed to greatly reduce or eliminate HA interference, and has now replaced the original reagents. The present study shows that the enhanced reagent significantly reduced or eliminated much of the HA interference. Comparative studies between the enhanced cTnI reagent and the original Abbott AxSYM cTnI reagent showed excellent correlation and equivalent diagnostic concordance, when HA samples were excluded from the analysis.
Aluminum Alloys Bipolar Plates Modified by Non-isothermal Deposition and Displacement Deposition Methods (2009)

Abstract not Available.
Colocalization of thrombospondin and syndecan during murine development (1992)

Thrombospondin is an adhesive glycoprotein that is thought to play a role in tissue genesis and repair. We have used a monoclonal anti-thrombospondin antibody, designated 5G11, to localize thrombospondin in paraformaldehyde fixed, paraffin-embedded sections of developing mouse embryos. Thrombospondin expression is observed in uterine smooth muscle, endometrial glands, the decidua, and trophoblastic giant cells during the initial phase of post-implantation development in the embryo. Cardiac myocytes and neuroepithelial cells show positive staining for thrombospondin at day 8.5 of gestation, and this expression continues throughout the development of the myocardium and central nervous system. Strong staining for thrombospondin is seen in developing bone and in the liver. Thrombospondin is also observed in developing smooth muscle and skeletal muscle, as well as in a variety of epithelia, including the epidermis, small intestinal epithelium, lens epithelium, renal tubular epithelium, and the epithelium of the developing tooth. Comparison of thrombospondin staining with that of two known cell surface receptors for thrombospondin, syndecan and the vitronectin receptor, reveals remarkable colocalization of thrombospondin and syndecan in all tissues, but almost no coexpression with the vitronectin receptor. Coexpression of thrombospondin and syndecan may play an important role in cell-cell or cell-matrix interactions during development.
A GRASP with path-relinking for the p-median problem (2002)

Given n customers and a set F of m potential facilities, the p-median problem consists in finding a subset of F with p facilities such that the cost of serving all customers is minimized. This is a well-known NPcomplete problem with important applications in location science and classification (clustering). We present here a GRASP (Greedy Randomized Adaptive Search Procedure) with path-relinking to find near-optimal solutions to this problem. Empirical results on instances from the literature suggest that this is a very robust algorithm, performing at least as well as other methods, and often better in terms of both running time and solution quality.
Automated Teller Machine (ATM) Operation Features and Usage in Ghana: Implications for Managerial Decisions (2014)

Abstract. Automated Teller Machine (ATM) packages of banks in Ghana have operated for a very long time without full exploration of all essential functions of the facility and this has baffled the minds of the public and other decision makers about the effect of ATM operations on customer demand for it. It is in line with this view that this study was conducted to assess the operational features of the ATM and the factors that account for customers ‟ willingness to use ATM. The study modelled the operational features of ATM using queuing modelling and a probit model was estimated to determine the factors affecting customer usage of ATM. Data was collected from 160 customers of banks with ATM facilities in the Wa Municipality. It was realized that there is a high traffic intensity for ATMs use for most banks in the Municipality. Also, higher educational attainment, number of ATMs per bank, convenience, security features, efficiency and low transaction charges have significant effect on influencing the usage of ATM services. It is recommended that management of these banks need to upsurge the number and quality of ATM services in order to increase access and usage of ATM.
Image deconvolution using a Gaussian Scale Mixtures model to approximate the wavelet sparseness constraint (2009)

This paper proposes to use an extended Gaussian Scale Mixtures (GSM) model instead of the conventional l <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> norm to approximate the sparseness constraint in the wavelet domain. We combine this new constraint with subband-dependent minimization to formulate an iterative algorithm on two shift-invariant wavelet transforms, the Shannon wavelet transform and dual-tree complex wavelet transform (DTCWT). This extented GSM model introduces spatially varying information into the deconvolution process and thus enables the algorithm to achieve better results with fewer iterations in our experiments.
Legierter Guß im chemischen Apparatebau (1956)

Abstract Es wird die chemische Widerstandsfähigkeit geschildert von Nickel‐Grauguß, Eisen‐Chromguß, Eisen‐Chrom‐Nickelguß (auch mit Zusatz von Molybdän), Eisen‐Siliciumguß (auch mit Molybdänzusatz), Nickel‐Molybdänguß (auch mit Chromzusatz) und Nickel‐Siliciumguß. Dabei werden Anwendungsbeispiele aufgezeigt. Besonders eingegangen wird awf die Erzeugnisse der Bergischen Stahlindustrie, Remscheid.