gebhart/patrepeval huggingface dataset:
STUDY OF ADOPTIVE IMMUNOTHERAPY FOR METASTATIC RENAL CELL CARCINOMA WITH LYMPHOKINE-ACTIVATED KILLER (LAK) CELLS AND INTERLEUKIN-2 (1993)

We evaluated adoptive immunotherapy using LAK cells combined with systemic administration of interleukin-2 (IL-2) in 11 patients with metastatic renal cell carcinoma. The LAK cells were generated by incubation in serum-free medium (AIM-V) supplemented with IL-2 (1,000 U/ml) for 4 days and were generally administered twice weekly (4 times/cycle). Daily administration of IL-2 (50 x 10(5) U) was started 3 days prior to the first LAK infusion and continued throughout the cycle. Each course of therapy comprised 1-6 cycles, with the total dose of LAK cells and IL-2 varying from 3.3-52.6 x 10(9) cells and 140-900 x 10(5) U, respectively. Clinical response was evaluated in terms of metastasis to specific organs (lung only: eight cases, lung and brain: one, lung and lymph nodes: one, lung and bone and pleuropericardium: one). The outcome was complete response in one patient, partial response in one, no change in six and disease progression in three. The response rate was 18.8%. This therapy was most effective against pulmonary metastases. Adverse reactions to LAK cell infusion included fever, headache, and chills. Eosinophilia and weight gain due to IL-2 administration were also observed. However, all of these symptoms were transient and no serious side effects occurred. In these patients, the proportion of natural killer (NK) cells (CD16) and cells with IL-2 receptor (CD25) among PBL was increased markedly in the early phase of therapy, and activated T cell (CD3+DR+) and suppressor T cells (CD8+11+) increased significantly at a later phase. It was suggested that the clinical response would be expected in case of increasing of CD16 cells or CD25 cells and augmentation of NK or LAK activity. Our results indicate that this regimen of adoptive immunotherapy shows some promise for the treatment of advanced renal cell carcinoma.
Racial differences in resting end-tidal CO2 and circulating sodium pump inhibitor (2001)

Previous studies have shown that high end-tidal CO2 (PetCO2) is a marker for sodium sensitivity of blood pressure (BP) in White Americans, and that the BP of African Americans is more sensitive to high sodium intake than that of whites. The present study tested the hypothesis that resting PetCO2 is higher in normotensive African Americans than in whites. Resting end-tidal CO2 of 395 white and 125 African American participants in the Baltimore Longitudinal Study on Aging was monitored for 20 min with a respiratory gas monitor, and BP and heart rate were recorded every 5 min by oscillometric methodology. Twenty-four-hour urinary excretion of a circulating sodium pump inhibitor marinobufagenin-like compound (MBG), which increases when plasma volume is expanded, was also analyzed by fluoroimmunoassay in racial groups. Mean resting PetCO2 of African American men was higher than that of white men (38.1+/-0.5 v 36.4+/-0.3 mm Hg), and resting PetCO2 of African American women was higher than that of white women (37.7+/-0.3 v 36.2+/-0.3 mm Hg). The differences were not significant in either men or women less than 50 years old, but were substantial in both men and women more than 50 years. Twenty-four-hour urinary excretion of MBG was higher in white (2.7+/-0.2 pmol) than in African American (2.1+/-0.2 pmol) participants, and high PetCO2 was a significant independent predictor of high MBG excretion in African Americans. These data are consistent with the hypothesis that the higher resting PetCO2 in African Americans plays a role in slower urinary excretion of sodium, greater BP sensitivity to high sodium intake, and increased prevalence of chronic hypertension.
On the Measurement of Roller Skew of Tapered Roller Bearings (2012)

Roller skew in roller bearings can cause heat generation and reduce bearing life. Therefore, design to minimise its occurrence is essential in bearing development. This study investigated the roller skew of a double row tapered roller bearing under various running conditions. A new system of measurement using two differential variable reluctance transducers (DVRT) was developed. It is evident that the roller skew of the double row tapered roller bearing can be measured. The shaft rotational speed has a significant effect on roller skew but the radial load has little effect.
Production of Chemotactic Activity by Guinea Pig Immunoglobulins Following Activation of the C3 Complement Shunt Pathway (1972)

Abstract Guinea pig γ1 and γ2 immunoglobulins consume late C components (C3 to C9) when incubated with C4 deficient guinea pig serum. The γ2 antibodies produce greater hemolytic activity losses in normal than in C4 deficient guinea pig serum. In contrast, consumption of late component activity by the γ1 antibodies is similar in serum containing or lacking C4. Both types of immunoglobulins produce a serumderived factor chemotactic for rabbit polymorphonuclear leukocytes in either normal or C4 deficient serum. This factor has been identified as a cleavage product of C5.
Genetic basis for natural variation in seed vitamin E levels in <i>Arabidopsis thaliana</i> (2006)

Vitamin E is an essential nutrient for humans and is obtained primarily from food, especially oil, derived from the seed of plants. Genes encoding the committed steps in vitamin E synthesis in plants (VTE, loci 1-5) have been isolated and used for tocopherol pathway engineering with various degrees of success. As a complement to such approaches we have used quantitative trait loci analysis with two sets of Arabidopsis thaliana recombinant inbred lines and have identified 14 QVE (quantitative vitamin E) loci affecting tocopherol content and composition in seeds. Five QVE intervals contain VTE loci that are likely QVE gene candidates. Nine QVE intervals do not contain VTE loci and therefore identify novel loci affecting seed tocopherol content and composition. Several near-isogenic lines containing introgressions of the accession with increased vitamin E levels were shown to confer significantly elevated tocopherol levels compared with the recurrent parent. Fine-mapping has narrowed QVE7 (a gamma-tocopherol quantitative trait loci) to an 8.5-kb interval encompassing two genes. Understanding the basis of the QVE loci in Arabidopsis promises to provide insight into the regulation and/or metabolism of vitamin E in plants and has clear ramifications for improving the nutritional content of crops through marker-assisted selection and metabolic engineering.
IndoWordNet Conversion to Web Ontology Language (OWL) (2016)

WordNet plays a significant role in Linked Open Data (LOD) cloud.It has numerous application ranging from ontology annotation to ontology mapping.IndoWord-Net is a linked WordNet connecting 18 Indian language WordNets with Hindi as a source WordNet.The Hindi WordNet was initially developed by linking it to English WordNet.In this paper, we present a data representation of IndoWordNet in Web Ontology Language (OWL).The schema of Princeton WordNet has been enhanced to support the representation of IndoWordNet.This IndoWordNet representation in OWL format is now available to link other web resources.This representation is implemented for eight Indian languages.
Bolaform Molecules Directing Intergrown Zeolites (2018)

Understanding of epitaxial and rotational intergrowth is particularly important for the design and synthesis of hierarchically structured zeolites. Herein, we propose a new route for fabricating hierarchical MTW- and MFI-type zeolites with intergrown structures by tuning the methylene chain lengths between the two N-heterocycles in bolaform quaternary ammonium structure-directing agents (SDAs). MTW-type zeolites with 66.4° rotational intergrowth and MFI-type zeolites with 90° rotational intergrowth were synthesized with methylene chain lengths of 4–6 and 7–9, respectively. A possible theoretical evidence of the geometrical match between SDAs and zeolite structures was proposed by the binding energy obtained by molecular mechanics calculations. It is speculated that the bolaform SDAs are located in the straight 12-membered ring (MR) channels along the b direction of MTW topology, directing the intergrown structure by sharing the (310) plane. The bolaform SDAs located in the intersections of straight 10-MR channels and sinusoidal 10-MR channels of MFI topology directed the intergrown structure by sharing the (010) plane. The hierarchical zeolite catalysts prepared using this strategy, characteristic of hybrid micro- and mesoporosities, proved to be useful for tandem cracking reactions involving bulky molecules.
X-Ray Evidence for a Conformational Change in the Actin-containing Filaments of Vertebrate Striated Muscle (1973)

The control of vertebrate striated muscle from rest to activity is regulated by the combination of the regulatory proteins tropomyosin and troponin on the thin actin filament (see reviews by Ebashi and Endo, 1968; Ebashi et al., 1969). In the absence of calcium the regulatory proteins inhibit the actin-myosin interaction. Activation of muscle is caused by calcium binding to troponin which then removes the inhibition. Since there is only one troponin molecule for every seven actin molecules (Weber and Bremel, 1971) and troponin does not interact with actin, then the control of activation is presumably mediated by the tropomyosin molecules which run along the grooves in the actin filaments (Hanson and Lowy, 1963; Moore et al., 1971). It is, therefore, of importance to investigate any structural changes that occur in the thin filaments when actin-myosin interaction is allowed to take place, for such changes may give us information about the...
Feature Selection Using Harmony Search for Script Identification from Handwritten Document Images (2017)

Abstract The feature selection process can be considered a problem of global combinatorial optimization in machine learning, which reduces the irrelevant, noisy, and non-contributing features, resulting in acceptable classification accuracy. Harmony search algorithm (HSA) is an evolutionary algorithm that is applied to various optimization problems such as scheduling, text summarization, water distribution networks, vehicle routing, etc. This paper presents a hybrid approach based on support vector machine and HSA for wrapper feature subset selection. This approach is used to select an optimized set of features from an initial set of features obtained by applying Modified log-Gabor filters on prepartitioned rectangular blocks of handwritten document images written in either of 12 official Indic scripts. The assessment justifies the need of feature selection for handwritten script identification where local and global features are computed without knowing the exact importance of features. The proposed approach is also compared with four well-known evolutionary algorithms, namely genetic algorithm, particle swarm optimization, tabu search, ant colony optimization, and two statistical feature dimensionality reduction techniques, namely greedy attribute search and principal component analysis. The acquired results show that the optimal set of features selected using HSA gives better accuracy in handwritten script recognition.
Upper Airway Mucin Gene Expression: A Review (2007)

Studies including adequate numbers of samples (patients) are more likely to reveal a clearer profile and more precise expression patterns. Generating a clear profile of mucin expression patterns in health and disease requires the analysis of different variables, which can alter that expression. It is also essential to understand the various molecular mechanisms controlling mucin gene and protein expression. This could lead to the invention of novel therapeutic modalities to treat upper airway diseases.
ChemInform Abstract: Diastereoselective Additions of Chiral (E)‐Crotylsilanes to α‐Alkoxy and β‐Alkoxy Aldehydes. A One‐Step, Silicon‐Directed Tetrahydrofuran Synthesis. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An organic neurophysiological tool for neuronal metabolic activity monitoring (2018)

Monitoring cell metabolism <i>in vitro</i> is considered a relevant methodology in several scientific fields ranging from fundamental biology research to neuro-toxicology. In the last 20 years, several <i>in vitro</i> neuro-pharmacological and neuro-toxicological approaches have been developed, with the intent of addressing the increasing demand for real-time, non-invasive <i>in vitro</i> systems capable of continuously and reliably monitoring cellular activity. In this paper, an Organic Charge Modulated Field Effect Transistor-based device is proposed as a promising tool for neuro-pharmacological applications, thanks to its ultra-high pH sensitivity and a simple fabrication technology. The preliminary characterization of this versatile organic device with primary neuronal cultures shows how these remarkable properties can be exploited for the realization of ultra-sensitive metabolic probes, which are both reference-less and low cost. These features, together with the already assessed capability of this sensor to also monitor the electrical activity of electrogenic cells, could provide important advances in the fabrication of multi-sensing lab-on-chip devices, thus opening up interesting perspectives in the neuro-pharmacological field.
Rail Transport in Bulgaria Upcoming Challenges (2014)

EU enlargement creates new challenges and opportunities that affect the market for rail transport services. While new business opportunities are developed with the growth of international trade, they would have to oppose the policy of deregulation, which will impact both on current concepts of secure and protected national markets and the accelerated development of infrastructure of transport competitive modes, in particular rail passenger transport. To compete in this new global business environment the railway companies in Bulgaria have no other alternative but to expand their business beyond national transport market in rail services, including in the new pan-European perspectives. This will allow them to focus on large amounts of new market segments. To be successful this new business needed rail transport to reach the best economic performance and productivity of work. Achieving this goal requires an adequate and efficient railway infrastructure which will be able to meet the ever- increasing demands on the transport service by users - transport time, reliability and quality of transport services that meet the specific needs of customers.
Inhibition of preprotein processing in ascites tumor lysates by incorporation of a leucine analog (1980)

Leucine analogs were tested in the Krebs II ascites cell-free translation system for the ability to inhibit preprotein cleavage by replacing leucine in nascent chains of bovine preprolactin, rat preprolactin, human placental prelactogen (pre-hPL), and pre-alpha subunit of human chorionic gonadotropin (alpha-hCG). In the absence of analog, ascites microsomal membranes cleaved these preproteins to their mature forms and sequestered the processed products. Also, two asparagine residues in alpha-hCG were glycosylated. When 4 mM beta-DL-hydroxyleucine was added to the lysate instead of L-leucine, cotranslational processing and sequestration of both species of preprolactin and pre-hPL were inhibited. Sequential Edman degradation confirmed that pre-hPL was not cleaved. The inhibition of processing by beta-hydroxyleucine resulted from its incorporation into protein. This was shown by reversal of the effect by addition of leucine and by inhibition of [(3)H]leucine incorporation into protein. Of significance, the processing of pre-alpha-hCG was less sensitive to beta-hydroxyleucine because its prepeptide contains only four scattered leucine residues, whereas the presegments of hPL and the prolactins contain six to eight clustered leucine residues. These experiments demonstrate that translocation and processing of secretory proteins require structural features determined by the primary amino acid sequence.
Identification and <i>In Vitro</i> Expansion of Buccal Epithelial Cells (2018)

Ex vivo-expanded buccal mucosal epithelial (BME) cell transplantation has been used to reconstruct the ocular surface. Methods for enrichment and maintenance of BME progenitor cells in ex vivo cultures may improve the outcome of BME cell transplantation. However, the parameter of cell seeding density in this context has largely been neglected. This study investigates how varying cell seeding density influences BME cell proliferation and differentiation on tissue culture polystyrene (TCPS). The highest cell proliferation activity was seen when cells were seeded at 5×10<sup>4</sup> cells/cm<sup>2</sup>. Both below and above this density, the cell proliferation rate decreased sharply. Differential immunofluorescence analysis of surface markers associated with the BME progenitor cell population (p63, CK19, and ABCG2), the differentiated cell marker CK10 and connexin 50 (Cx50) revealed that the initial cell seeding density also significantly affected the progenitor cell marker expression profile. Hence, this study demonstrates that seeding density has a profound effect on the proliferation and differentiation of BME stem cells in vitro, and this is relevant to downstream cell therapy applications.
Structured reporting: if, why, when, how—and at what expense? Results of a focus group meeting of radiology professionals from eight countries (2012)

Structured reporting offers radiologists opportunities to improve their service to other stakeholders. • If radiologists can be convinced of the advantages of structured reporting, they may become early adopters. • The healthcare industry should propose technology allowing structured reporting. • Structured reporting will fail if it compromises accuracy, completeness, workflows or cost-benefit balance.
Multifeature Prostate Cancer Diagnosis and Gleason Grading of Histological Images (2007)

We present a study of image features for cancer diagnosis and Gleason grading of the histological images of prostate. In diagnosis, the tissue image is classified into the tumor and nontumor classes. In Gleason grading, which characterizes tumor aggressiveness, the image is classified as containing a low- or high-grade tumor. The image sets used in this paper consisted of 367 and 268 color images for the diagnosis and Gleason grading problems, respectively, and were captured from representative areas of hematoxylin and eosin-stained tissue retrieved from tissue microarray cores or whole sections. The primary contribution of this paper is to aggregate color, texture, and morphometric cues at the global and histological object levels for classification. Features representing different visual cues were combined in a supervised learning framework. We compared the performance of Gaussian, k-nearest neighbor, and support vector machine classifiers together with the sequential forward feature selection algorithm. On diagnosis, using a five-fold cross-validation estimate, an accuracy of 96.7% was obtained. On Gleason grading, the achieved accuracy of classification into low- and high-grade classes was 81.0%.
The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44 (2003)

We have characterized a cluster of single immunoglobulin variable (IgV) domain receptors centromeric of the major histocompatibility complex (MHC) on human chromosome 6. In addition to triggering receptor expressed on myeloid cells (TREM)-1 and TREM2, the cluster contains NKp44, a triggering receptor whose expression is limited to NK cells. We identified three new related genes and two gene fragments within a cluster of approximately 200 kb. Two of the three new genes lack charged residues in their transmembrane domain tails. Further, one of the genes contains two potential immunotyrosine Inhibitory motifs in its cytoplasmic tail, suggesting that it delivers inhibitory signals. The human and mouse TREM clusters appear to have diverged such that there are unique sequences in each species. Finally, each gene in the TREM cluster was expressed in a different range of cell types.
An approach to Produce Biodiesel From Non-edible <i>Jatropha curcus</i> Oil through Dual Step Process: Preesterification and Transesterification (1970)

Studies were carried out to produce potential biodiesel from non-edible oil of Jatropha curcus. Due to its high free fatty acid (12% FFA), the crude Jatropha oil was processed in two steps: the acid-catalyzed esterification and followed by the base-catalyzed transesterification. The first step reduced the FFA level to less than 1% in 1h at 50°C for the 0.40 w/w methanol-to-oil ratio with 1% w/w of H2SO4. After the reaction, the mixture was stagnated for an hour and the methanol-water upper layer was discarded. The second step converted the product of the first step into biodiesel and glycerol through transesterification using 0.20 w/w methanol-to-oil and 0.5% w/w NaOH to oil as alkaline catalyst at 65°C. The maximum yield of biodiesel (organic phase of upper layer) and fatty acid methyl esters (FAME) yield were achieved at about 95% and 84% within 1 hour respectively. The glycerol concentration in the byproduct (glycerol layer) obtained after dual step transesterification was found 32%. Key words: Jatropha curcus, Biodiesel, Esterification, Glycerol and Fatty acid DOI: 10.3329/bjsir.v44i3.4409 Bangladesh J. Sci. Ind. Res. 44(3), 347-352, 2009
Effect of propranolol on platelet function (1977)

Excessive reactivity of blood platelets may contribute to atherosclerotic vascular disease. Hence drugs which alter platelet function may be protective. Prompted by findings that propranolol therapy normalized hyperactive platelet aggregation in patients with coronary artery disease, we studied propranolol in vitro to assess its action on platelets. At concentrations similar to those achieved in vivo (0.1-1 muM), propranolol raised the thresholds for aggregation of some normal paltelets by adenosine diphosphate (ADP). At higher concentrations (10-50 muM), propranolol abolished the second wave of platelet aggregation induced by ADP and epinephrine, and inhibited aggregation induced by collagen, thrombin, and the ionophore A23187. Propanolol blocked the release of 14C-serotonin from platelets, inhibited platelet adhesion to collagen, and interfered with clot retraction. Propranolol blocked ionophore-induced uptake of 45Ca by platelets. Inhibition appeared unrelated to beta-adrenergic blockage, as d(+) propranolol (which lacks beta-blocking activity) was equipotent with 1(-) propranolol. Moreover, practolol, a beta-blockading drug which is nonlipophilic, did not inhibit platelet function. These studies suggested that propranolol, like local anesthetics, decreased platelet responsiveness by a direct action on the platelet membrane, possibly by interfering with calcium availability. Modulation of platelet function by propranolol may occur at concentrations achieved at usual clinical doses of the drug.