gebhart/patrepeval huggingface dataset:
Fhl2 Interacts with Foxk1 and Corepresses Foxo4 Activity in Myogenic Progenitors (2009)

Adult skeletal muscle has a remarkable regenerative capacity because of a myogenic progenitor cell population. Using a gene disruption strategy, we determined that Foxk1 regulates myogenic progenitor cell activation and muscle regeneration. In this study, we undertook a yeast two hybrid screen to identify Foxk1 interacting proteins. We identified the LIM-only protein, Fhl2, as a Foxk1 interacting protein. Using transcriptional assays, we observed that Fhl2, in a dose-dependent fashion, promotes Foxk1 transcriptional repression of Foxo4 activity. Using histochemical and immunohistochemical assays, we further established that Fhl2 is expressed in the myogenic progenitor cell population. Fhl2 knockdown results in cell cycle arrest, and mice lacking Fhl2 have perturbed skeletal muscle regeneration. Collectively, these studies define a Fhl2-Foxk1 cascade that regulates the myogenic progenitor cell activity in adult skeletal muscle and enhances our understanding of muscle regeneration.
Optical scanning with MEMS in-plane vibratory gratings and its applications (2010)

MEMS optical scanners are highly desired due to their low-power, high-speed scanning. The in-plane vibratory grating scanner is a development in this area which possesses several unique features. The in-plane scanning minimizes the dynamic deformation, allowing for higher-resolution displays. The dispersive element permits splitting the incoming beam into its constituents for analysis and imaging. Coupling a grating platform to an in-plane moving structure is useful for real-time motion measurement which would otherwise be difficult to analyze. These applications are described including a recent development in the structural design of a double-layer layout which further improves the performance of the grating scanner.
The Optimum Plutonium Fuel Form in Light Water Reactors (2003)

The University of Florida has underway a research program to validate the benefits of developing a Pu/ZrH/U matrix fuel for the irradiation of the U.S. weapons plutonium and European reprocessed plutonium from an economic, operational, and performance basis. Thermal reactors using plutonium as a fuel are inherently undermoderated because of the large absorption cross sections of plutonium and the presence of large absorption resonances for plutonium in the thermal and near‐thermal energy ranges. The use of the proven TRIGA ZrHx‐based fuel with plutonium has shown an extremely large (>20%) increase in reactivity over the conventional UO2/PuO2 fuel form currently being considered, with an additional major increase in the destruction of plutonium, rendering it an extremely attractive fuel form for plutonium disposition.
Social networks (2008)

By now, online social networks have become an indispensable part of both online and offline lives of human beings. A large fraction of time spent online by a user is directly influence by the social networks to which he/she belongs. This calls for a deeper examination of social networks as large-scale dynamic objects that foster efficient person-person interaction.
Keeping tabs on fructose (2016)

Too much fructose in the diet can worsen metabolic problems via a process that involves thioredoxin-interacting protein.
Excited-state chemistry of indigoid dyes. III. Interaction of indigo and thioindigo with tin(IV) tetraphenyltetrahydroporphyrin triplets. Photosensitized isomerization of thioindigo (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleExcited-state chemistry of indigoid dyes. III. Interaction of indigo and thioindigo with tin(IV) tetraphenyltetrahydroporphyrin triplets. Photosensitized isomerization of thioindigoGeorge M. Wyman, Bizhan M. Zarnegar, and David G. WhittenCite this: J. Phys. Chem. 1973, 77, 21, 2584–2586Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/j100907a020https://doi.org/10.1021/j100907a020research-articleACS PublicationsRequest reuse permissionsArticle Views162Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Tracking latency in image-based dynamic MLC tracking with direct image access (2011)

kV and MV image-based DMLC tracking was successfully integrated with direct image access. It resulted in substantial tracking latency reductions compared with image-based tracking without direct image access.
Battery energy storage and wind energy integrated into the Smart Grid (2012)

Innovations in electricity infrastructure of today's Smart Grid will allow distributed renewable resources to provide transmission level support when combined with new energy storage technology. The modernization of the existing grid requires the implementation of controls and communication architecture that are capable of coordinating as available resources such as wind generation, energy storage and loads in order to improve the efficient and economic operation of the electric power distribution system. Integration of energy storage systems into the Smart Grid can manage the real power variability of wind generation by providing ramp rate variation control and frequency regulation via droop control response. These control features drastically increase reliability of the Smart Grid, enables more effective grid management. Operational issues raised by the variability and high ramping characteristics of wind generation can be mitigated with the integration of battery energy storage systems. This paper presents several control methodologies for battery energy storage systems. Results are discussed particularly with respect to developing better insight into the dynamic performance of such resources and how to manage problems associated with the viability in real power output of wind generation.
A building performance evaluation &amp; visualization system (2014)

A novel big data building performance evaluation knowledge processing and mining system utilizing visual analytics is going to be presented in this paper. A large dataset comprised of building information, energy consumption, environmental measurements, human presence and behavior and business processes is going to be exploited for the building performance evaluation. Building performance evaluation is one of the most important factors in engineering that leads to building renovation and construction with low energy consumption and gas emissions in conjunction with comfort, utility and durability. For this purpose, business processes occurring in the building are correlated with the energy consumption and the human flows in the spatiotemporal domain modeling the dynamic behavior of the building. These models lead to the extraction of useful semantic information and the detection of spatiotemporal patterns that are important for the evaluation of the building performance. Furthermore, a number of novel visual analytics techniques allow the end-users to process data in different temporal resolutions and with different temporal filters, assisting them to detect patterns that may be difficult to be detected otherwise. The proposed visual analytics techniques support design and energy management decisions by visualizing the building measurements regarding business and comfort aspects. To do so, the proposed system includes a variety of techniques and components, properly selected to offer quick identification of focal points and evaluation of the building performance. Considering the increasing interest and the green building goals of almost all world governments including EU, the suggested methodology and application could be rendered a very useful tool for the Architecture and Engineering Community working on Building Performance Simulation and Analysis, and all related communities in Architect, Engineering and Construction (AEC) industry.
Assessing the Quality of Regional Climate Information (2020)

Abstract There are now a plethora of data, models, and approaches available to produce regional and local climate information intended to inform adaptation to a changing climate. There is, however, no framework to assess the quality of these data, models, and approaches that takes into account the issues that arise when this information is produced. An evaluation of the quality of regional climate information is a fundamental requirement for its appropriate application in societal decision-making. Here, an analytical framework is constructed for the quality assessment of science-based statements and estimates about future climate. This framework targets statements that project local and regional climate at decadal and longer time scales. After identifying the main issues with evaluating and presenting regional climate information, it is argued that it is helpful to consider the quality of statements about future climate in terms of 1) the type of evidence and 2) the relationship between the evidence and the statement. This distinction not only provides a more targeted framework for quality, but also shows how certain evidential standards can change as a function of the statement under consideration. The key dimensions to assess regional climate information quality are diversity, completeness, theory, adequacy for purpose, and transparency. This framework is exemplified using two research papers that provide regional climate information and the implications of the framework are explored.
Quantum Optimally Controlled Transition Landscapes (2004)

A large number of experimental studies and simulations show that it is surprisingly easy to find excellent quality control over broad classes of quantum systems. We now prove that for controllable quantum systems with no constraints placed on the controls, the only allowed extrema of the transition probability landscape correspond to perfect control or no control. Under these conditions, no suboptimal local extrema exist as traps that would impede the search for an optimal control. The identified landscape structure is universal for all controllable quantum systems of the same dimension when seeking to maximize the same transition probability, regardless of the detailed nature of the system Hamiltonian. The presence of weak control field noise or environmental decoherence is shown to preserve the general structure of the control landscape, but at lower resolution.
Tuning the DNA Conformational Perturbations Induced by Cytotoxic Platinum−Acridine Bisintercalators: Effect of Metal Cis/Trans Isomerism and DNA Threading Groups (2008)

Four highly charged, water soluble platinum-acridine bisintercalating agents have been synthesized. Depending on the cis/trans isomerism of the metal and the nature of the acridine side chains, bisintercalation induces/stabilizes the classical Watson-Crick B-form or a non-B-form. Circular dichroism spectra and chemical footprinting experiments suggest that 4, the most active derivative in HL-60 cells, produces a structurally severely perturbed DNA with features of a Hoogsteen base-paired biopolymer.
Programming language support for writing fault-tolerant distributed software (1995)

Good programming language support can simplify the task of writing fault-tolerant distributed software. Here, an approach to providing such support is described in which a general high-level distributed programming language is augmented with mechanisms for fault tolerance. Unlike approaches based on sequential languages or specialized languages oriented towards a given fault-tolerance technique, this approach gives the programmer a high level of abstraction, while still maintaining flexibility and execution efficiency. The paper first describes a programming model that captures the important characteristics that should be supported by a programming language of this type. It then presents a realization of this approach in the form of FT-SR, a programming language that augments the SR distributed programming language with features for replication, recovery, and failure notification. In addition to outlining these extensions, an example program consisting of a data manager and its associated stable storage is given. Finally, an implementation of the language that uses the x-kernel and runs standalone on a network of Sun workstations is discussed. The overall structure and several of the algorithms used in the runtime are interesting in their own right.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding. (1976)

Human lymphocytes are known to posessess a catecholamine-responsive adenylate cyclase which has typical beta-adrenergic specificity. To identify directly and to quantitate these beta-adenergic receptors in human lymphocytes, (-) [3H] alprenolol, a potent beta-adrenergic antagonist, was used to label binding sites in homogenates of human mononuclear leukocytes. Binding of (-) [3H] alprenolol to these sites demonstrated the kinetics, affinity, and stereospecificity expected of binding to adenylate cyclase-coupled beta-adrenergic receptors. Binding was rapid (t1/2 less than 30 s) and rapidly reversible (t1/2 less than 3 min) at 37 degrees C. Binding was a saturable process with 75 +/- 12 fmol (-) [3H] alprenolol bound/mg protein (mean +/- SEM) at saturation, corresponding to about 2,000 sites/cell. Half-maximal saturation occurred at 10 nM (-) [3H] alprenolol, which provides an estimate of the dissociation constant of (-) [3H] alprenolol for the beta-adrenergic receptor. The beta-adrenergic antagonist, (-) propranolol, potently competed for the binding sites, causing half-maximal inhibition of binding at 9 nM. beta-Adrenergic agonists also competed for the binding sites. The order of potency was (-) isoproterenol greater than (-) epinephrine greater than (-)-norepinephrine which agreed with the order of potency of these agents in stimulating leukocyte adenylate cyclase. Dissociation constants computed from binding experiments were virtually identical to those obtained from adenylate cyclase activation studies. Marked stereospecificity was observed for both binding and activation of adenylate cyclase. (-)Stereoisomers of beta-adrenergic agonists and antagonists were 9- to 300-fold more potent than their corresponding (+) stereoisomers. Structurally related compounds devoid of beta-adrenergic activity such as dopamine, dihydroxymandelic acid, normetanephrine, pyrocatechol, and phentolamine did not effectively compete for the binding sites. (-) [3H] alprenolol binding to human mononuclear leukocyte preparations was almost entirely accounted for by binding to small lymphocytes, the predominant cell type in the preparations. No binding was detectable to human erythrocytes. These results demonstrate the feasibility of using direct binding methods to study beta-adrenergic receptors in a human tissue. They also provide an experimental approach to the study of states of altered sensitivity to catecholamines at the receptor level in man.
Estimation for normal contact stiffness of joint surfaces by considering the variation of critical deformation (2020)

Purpose This paper aims to study the relationship between normal contact stiffness and contact load. It purpose a new calculation model of the normal contact stiffness of joint surfaces by considering the elastic–plastic critical deformation change of asperities contact. Design/methodology/approach The paper described the surface topography of joint surfaces based on fractal geometry, and fractal parameters and of fractal function derived from measurement data. According to the plastic–elastic contact theory, the contact deformation characteristic of asperities was analyzed; the critical deformation estimation model was presented, which expressed critical deformation as the function of fractal parameters and contact deformation; the contact stiffness calculation model of single asperity was brought forward by considering critical deformation change. Findings The paper combined the surface topography description function, analyzed the asperity contact states by considering the critical deformation change, and calculated normal contact stiffness based on fractal theory and contact deformation analysis. The comparison between theoretical contact stiffness and experimental data indicated that the theoretical normal contact stiffness agreed with the experimental data, and the estimation model for normal contact stiffness was appropriate. Research limitations/implications Owing to the possibility of plastic deformation during the loading process, the experimental curve between the contact stiffness and the contact load is nonlinear, resulting in an error between the experimental results and the theoretical calculation results. Originality/value The paper established the relationship between critical deformation and fractal surface topography by constructing asperity distribution function. The paper proposed a new normal contact stiffness calculation model of joint surfaces by considering the variation of critical deformation in contact process.
Emulating prosthetic feet during the prescription process to improve outcomes and justifications (Invited Presentation) (2014)

The current process of prescribing prosthetic feet is hampered by imprecise classifications based on self-assessment, recommendations based on subjective prediction, burdensome justification requirements, and slow, costly testing of devices. These problems have been exacerbated by the introduction of robotic prostheses, which can improve gait performance for some individuals, but are very expensive. We propose an alternative process, in which a versatile robotic emulator is used to preview patient interactions with a range of prostheses, while objective data related to effort, stability, speed and preference are collected, all prior to prescription. Results from pilot testing with a proto- type emulator system demonstrate accurate haptic rendering of a wide range of prosthesis classes and differentiation of user performance across these classes. Eventually, emulation-based prescription could reduce bias, cost and waste in the prescription process, while simultaneously improving patient outcomes. I. THE CONVENTIONAL PRESCRIPTION PROCESS About 150,000 lower-limb prosthesis prescriptions are made each year in the United States. The majority arise from the more than 100,000 lower-limb amputations performed each year, while others are the result of replacement, e.g., due to wear. During a typical prescription, the patient first receives a generic script from a physician. A prosthetist then recommends a particular device based on the patient's self-reported activity level, weight and height, and residual limb geometry. These data have low resolution, and the prosthetist's subjective judg- ment and personal experience therefore must play a significant role in the recommendation. Following verification from the physician, a prosthetic device is ordered and a custom socket adapter is fabricated for the patient's residual limb. Finally, the patient receives the complete prosthesis, and the prosthetist performs a fitting in which the device is iteratively adjusted during short bouts of standing and walking.
Novel anterior-chamber angle measurements by high-definition optical coherence tomography using the Schwalbe line as the landmark (2010)

Seventy-three (47 females, 26 males) subjects were recruited, the majority of whom were Chinese (89%). The authors excluded 29 images (19.9%) owing to poor image quality, leaving 117 HD-OCT images (65 nasal, 52 temporal) for analysis. SL and SS could be identified in 95% and 85% of quadrants respectively (p = 0.035). SL-AOD and SL-TISA were significantly correlated with SS parameters (all r ≥ 0.85) and gonioscopic grading (all r ≥ 0.69). In eyes with closed angles (n = 36), SL parameters showed strong correlations with gonioscopic grading (r ranged from 0.43 to 0.44). Conclusions Novel angle parameters, based on SL as a landmark, may be useful to quantify ACA width and to assess for risk of angle closure.
Synthesis of Nitrogen-containing Heterocyclic Compounds. XX. Improvement of One-step Synthesis of Phenanthrolines and Some Reactions of 4, 6-Phenanthroline (1974)

1, 9-Diazaanthracene (IV), 4-methyl-1, 9-diazaanthracene (V), 4, 6-phenanthroline (I), 1, 6-phenanthroline (III), and 5-methyl-1, 6-phenanthroline (II) were synthesized by the reaction of 2-, 3-, or 4-aminoquinolines with glycerol or methyl vinyl ketone, in the presence of sulfo-mix, ferrous sulfate, and boric acid. Methylation of I with methyl iodide afforded the monomethiodide (VI) in which methyl iodide was proved to have reacted with the nitrogen in 6-position. Chichibabin amination of I afforded 5-amino-4, 6-phenanthroline (VIII) and this amination was examined by comparison of reaction indices by the Huckel molecular orbital method.
Conceptual model for metal-ligand-surface interactions during adsorption (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConceptual model for metal-ligand-surface interactions during adsorptionMark M. Benjamin and James O. LeckieCite this: Environ. Sci. Technol. 1981, 15, 9, 1050–1057Publication Date (Print):September 1, 1981Publication History Published online1 May 2002Published inissue 1 September 1981https://pubs.acs.org/doi/10.1021/es00091a003https://doi.org/10.1021/es00091a003research-articleACS PublicationsRequest reuse permissionsArticle Views585Altmetric-Citations145LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts