gebhart/patrepeval huggingface dataset:
Psychiatric and EEG Observations on a Case of Prolonged (264 Hours) Wakefulness (1966)

THE FIRST sleep deprivation study on man was carried out in 1896 by Patrick and Gilbert,<sup>1</sup>who kept three young adults awake for 90 hours. Visual hallucinations occurred in one subject. In the ensuing years, a number of studies have been done and a frequent finding has been the development of some kind of psychotic symptomatology. Perceptual illusions, transient hallucinatory episodes, and depersonalization are among the most commonly observed symptoms.<sup>2-5</sup> With longer durations of sleep deprivation, more severe disturbances have been reported. Among 275 servicemen who had undergone 112 hours of sleep deprivation, Tyler<sup>6</sup>saw a few instances of behavior resembling symptoms of acute schizophrenia. Luby et al<sub>7</sub>reported a subject who developed a florid psychotic picture during the course of 220 hours of wakefulness which was completely reversed following 14 hours of sleep. The effects of sleep deprivation ordinarily disappear when
Tumor cell‐derived angiopoietin‐like protein 2 establishes a preference for glycolytic metabolism in lung cancer cells (2020)

We previously revealed that tumor cell-derived angiopoietin-like protein 2 (ANGPTL2) accelerates the metastatic capacity of tumors in an autocrine/paracrine manner by activating tumor cell motility and invasiveness and the epithelial-mesenchymal transition. However, the effects of ANGPTL2 on cancer cell glycolytic metabolism, which is a hallmark of tumor cells, are unknown. Here we report evidence supporting a role for tumor cell-derived ANGPTL2 in establishing a preference for glycolytic metabolism. We report that a highly metastatic lung cancer cell subline expressing abundant ANGPTL2 showed upregulated expression of the glucose transporter GLUT3 as well as enhanced glycolytic metabolism relative to a less metastatic parental line. Most notably, ANGPTL2 overexpression in the less metastatic line activated glycolytic metabolism by increasing GLUT3 expression. Moreover, ANGPTL2 signaling through integrin α5β1 increased GLUT3 expression by increasing transforming growth factor-β (TGF-β) signaling and expression of the downstream transcription factor zinc finger E-box binding homeobox 1 (ZEB1). Conversely, ANGPTL2 knockdown in the highly metastatic subline decreased TGF-β1, ZEB1, and GLUT3 expression and antagonized glycolytic metabolism. In primary tumor cells from patients with lung cancer, ANGPTL2 expression levels correlated with GLUT3 expression. Overall, this work suggests that tumor cell-derived ANGPTL2 accelerates activities associated with glycolytic metabolism in lung cancer cells by activating TGF-β-ZEB1-GLUT3 signaling.
Abstract W P59: Hemodynamic Changes in Wall Shear Stress in Arteriovenous Malformation Feeding Vessels Post Embolization (2014)

Objective: Arterio-venous malformations (AVM) feeders are known to remodel with time: increase in diameter when the AVM is present and decrease after the AVM is treated. In this study we used quantitative magnetic resonance angiography (QMRA) to evaluate changes in WSS, flow, and diameter of feeder vessels pre and post treatment with endovascular embolization/ surgery. Methods: 55 patients with AVM were evaluated with QMRA on presentation, 19 patients had QMRA post embolization (1-8 sessions), and 13 post-surgical resection. WSS, flow, and diameter of proximal feeder vessels (MCA, PCA and/or ACA) and their contralateral counterparts were derived from QMRA. These parameters were studied at baseline and compared between the feeder and contralateral artery pre and post embolization/surgery. Results: At baseline, WSS in feeder vessels (n=66) was greater than in the corresponding contralateral vessel (33.55 Dyne/cm2 vs. 24.76 Dyne/cm2; P<0.0001). These corresponded to a higher flow (296.7mL/min vs. 164.5mL/min; P = 0.0002) as well as a larger diameter (3.643mm vs. 3.257mm; P=0.0002). For embolized AVMs (n=28 feeder vessels), at the conclusion of final embolization, there was a drop in WSS (33.56 Dyne/cm2 to 22.97 Dyne/cm2; P =0.0003), flow (370mL/min to 176 mL/min; P = 0.0005), and diameter in (3.77mm to 3.522mm; P=0.0438) in feeder vessel. No significant change was seen in WSS in the contralateral vessel (23.2mm to 22.85mm; P =0.8770) post embolizations. The difference in WSS between the feeder and contralateral vessel became non-significant post embolization (22.97 Dyne/cm2 vs. 22.85 Dyne/cm2; P=0.8926). As compared to baseline, WSS dropped after surgery from 32.72 Dyne/cm2 to 20.5Dyne/cm2 (P= 0.0007). Conclusion: Arteriovenous malformation feeding vessels are subjected to a higher WSS secondary to higher blood flow. The feeders demonstrate a corresponding enlargement in diameter, as a presumed compensatory response to the high flow. However, the vessel enlargement is insufficient to normalize the WSS at baseline. There was decrease in diameter of the feeder vessel and normalization of the WSS post reduction of blood flow with embolization/surgery.
Mutational Analysis of Basic Residues in the Rat Vesicular Acetylcholine Transporter (2000)

The function of positively charged residues and the interaction of positively and negatively charged residues of the rat vesicular acetylcholine transporter (rVAChT) were studied. Changing Lys-131 in transmembrane domain helix 2 (TM2) to Ala or Leu eliminated transport activity, with no effect on vesamicol binding. However, replacement by His or Arg retained transport activity, suggesting a positive charge in this position is critical. Mutation of His-444 in TM12 or His-413 in the cytoplasmic loop between TM10 and TM11 was without effect on ACh transport, but vesamicol binding was reduced with His-413 mutants. Changing His-338 in TM8 to Ala or Lys did not effect ACh transport, however replacement with Cys or Arg abolished activity. Mutation of both of the transmembrane histidines or all three of the luminal loop histidines showed no change in acetylcholine transport. The mutant H338A/D398N between oppositely charged residues in transmembrane domains showed no vesamicol binding, however the charge reversal mutant H338D/D398H restored binding. This suggests that His-338 forms an ion pair with Asp-398. The charge neutralizing mutant K131A/D425N or the charge exchanged mutant K131D/D425K did not restore ACh transport. Taken together these results provide new insights into the tertiary structure in VAChT.
Hybrid Energy System Modeling in Modelica (2014)

In this paper, a Hybrid Energy System (HES) configuration is modeled in Modelica. Hybrid Energy Systems (HES) have as their defining characteristic the use of one or more energy inputs, combined with the potential for multiple energy outputs. Compared to traditional energy systems, HES provide additional operational flexibility so that high variability in both energy production and consumption levels can be absorbed more effectively. This is particularly important when including renewable energy sources, whose output levels are inherently variable, determined by nature.
Design of submicrometer CMOS differential pass-transistor logic circuits (1991)

The interaction between the architectural features of CMOS differential pass-transistor logic (DPTL) and the submicron process technology used to implement it are examined. Techniques that exploit the noise immunity associated with the DPTL architecture are presented to effectively enable signal-swing reductions that result in increased speed. The extent to which DPTL can benefit from this signal-swing/speed tradeoff is examined by investigating the impact of device scaling on DPTL operation. A novel DPTL buffer that enables the implementation of a single-phase clocking scheme and the exchange of signal swing for increased circuit speed is proposed. Experimental results are provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ITER LHCD Plans and Design (2005)

LH waves experimentally exhibit the highest current drive efficiency at low plasma temperature, therefore they are the most suitable candidates for controlling the current profile in the off axis part of ITER steady state plasmas. For this purpose, a 5 GHz, 20 MW CW LH system has been designed, that relies on a generator made of 24 klystrons, 1 MW each, 60 metres long circular oversized transmission lines, and one antenna, based on the Passive Active Multijunction (PAM) concept. High reliability of the launcher is achieved, by limiting the power density to 33 MW/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Together with the overall system description, the present results achieved toward ITER are presented. The different ongoing projects are listed. The outstanding problems are depicted
Lewis Acid Induced Intramolecular Friedel—Crafts Cyclization of 1,3‐Bis‐exocyclic Dienes. A New Route to 4a‐Methyltetrahydrofluorenes. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Transmission towers inventory (2002)

Transmission towers for major lines constitute a critical component because it is undesirable to lose any major transmission lines for longer than a few weeks. Since tower fabrication cannot be accomplished quickly on-demand, it is important to hold an adequate inventory of transmission towers. This paper discusses a statistical procedure to analyze failure data and estimate inventory requirements for transmission towers, using a homogeneous Poisson process model.
Host support of Ty3 retrotransposition in Saccharomyces cerevisiae (2009)

Ty3 is a Saccharomyces cereviae LTR retrotransposon. The structure of Ty3 is similar to that of a simple retrovirus. It is 5.4 kb in length and encodes overlapping GAG3 and POL3 reading frames flanked by 340 bp long terminal repeats. Expression of Ty3 results in production of Gag3 and Gag3-Pol3 polyproteins which assemble together with genomic RNA into in association with P-body proteins. VLPs are also associated with these clusters. The nucleo-capsid domain of Ty3 Gag3 is required in trans for recruitment of Ty3 RNA into P bodies. The untranslated regions of Ty3 RNA are sufficient in cis for recruitment of RNA to P bodies, but the GAG3-POL3 coding domain of the RNA can also confer association with P body proteins. In contrast, only the untranslated sequences confer packaging of a mini-Ty3 transcript. Upon assembly, Gag3 is processed into capsid, spacer, and nucleocapsid. Gag3-Pol3 is processed into those proteins and protease, junction, reverse transcriptase, and integrase. We propose that P-body proteins promote Ty3 VLP assembly and a mass spectrometry approach is being taken to further define the components of these dynamic complexes. However, in spite of genetic evidence that P-body proteins play a positive role in Ty3 production, these intracellular foci may also act as host traps to down-regulate transposition. Ty3-P body clusters become perinuclear over time and are physically associated with nuclear pores. A specific class of FG nucleoporins are required for Ty3 nuclear entry.
Neuronal injury in NCX3 knockout mice following permanent focal cerebral ischemia and in NCX3 knockout cortical neuronal cultures following oxygen-glucose deprivation and glutamate exposure (2009)

In this study we subjected NCX3 knockout and wildtype mice to permanent focal cerebral ischemia by intraluminal middle cerebral artery occlusion.Analysis of brain sections by 2,3,5-Triphenyl-2H-tetrazolium chloride staining, 12 hours after middle cerebral artery occlusion revealed no difference in infarct volume between NCX3 knockout and wildtype mice.In addition, we evaluated the effect of NCX3 protein knockdown on neuronal viability in primary cortical neuronal cultures following in vitro ischemia (oxygen-glucose deprivation) and L-glutamate (glutamate) exposure.In vitro experiments revealed that neuronal viability was higher in NCX3 knockout neuronal cultures than in the wildtype cultures following ischemic and glutamate insults.The reduced sensitivity of neurons from NCX3 knockout mice to in vitro ischemia and excitotoxicity indicates that NCX3 calcium entry mode activity contributes to calcium overload and neuronal death.However our in vivo finding of a lack of differential sensitivity on infarct volume in NCX3 knockout and wildtype mice suggests that any benefit of reduced NCX3 activity is overridden following permanent focal cerebral ischemia.Taken together, these findings suggest that reduced NXC3 activity limits calcium neurotoxicity during severe transient, but not during severe sustained ischemic insults.These results have important implications for the development of the NCX3 protein as a therapeutic target to reduce ischemic brain injury.
British and Australian Media (1977)

Annual Review of BBC Audience Research Findings (London: BBC, 1975 and 1976, two numbers issued so far at £1.00 each or about $1.85, paper) Egon Larsen's Radio and Television: The Everyday Miracle (London: J.M. Dent, 1976 [also the same publisher's Canadian office in Don Mills, Ontario]—£2.95, or about $5.50) The Media Reporter (Brennan Publications, 39 Legh Road, Sale, Cheshire, M33 2SU, England—L4.60 in British Isles, £6.00 elsewhere in Europe, and $14.00 overseas) Journalism Studies Review (Centre of Journalism Studies, University College, Cardiff, Y.K.—£1.75 or about $3.00 by post per year) Tenth Anniversary Report: 1974–76 of the Centre for Mass Communication Research (University of Leicester, 104 Regent Road, Leicester LEI 7LT) Media Information Australia (subscriptions are about $15.00 overseas from MIA, P.O. Box 1106, North Sydney, NSW 2060, Australia) Kevin Tindall, et al. Television: 20th Century Cyclops (AV Centre, Sydney Teacher's College, Newtown 2042, Australia—about $7.50 R.B. Walker, The Newspaper Press in New South Wales: 1803–1920 (Sydney: Sydney University Press, 1976—$12.50 Australian Film and Television School Monographs (write to Joy Sheppard, Australian Film and Television School, P.O. Box 126, North Ryde, NSW 2113, Australia) Performing Arts Yearbook of Australia (Sydney: Showcast Publications, 32a Roseberry St., Mosman 2088–$20.00) Nicholas Johnson and Mark Armstrong, Two Reflections on Australian Broadcasting (Glenda Wilson, Media Centre, La Trobe University, Bundoora 3083, Australia—$1.50 Trevor Barr, Reflections of Reality: The Media in Australia (Adelaide: Rigby, 1977—$9.95) Harold Hunt, The Master Printers of Sydney (Printing and Allied Trades Employers Federation, P.O. Box M162 Sydney Mail Exchange 2012—$15.00) CB Action (P.O. Box 628E, GPO Melbourne, Australia—new periodical Conference on Interpersonal and Mass Communication: Proceedings (Clarendon Press Pty Ltd., 256 Anzac Parade, Kensington, NSW Australia 2033—no price listed, paper Defamation—Options for Reform and Privacy and Publication—Proposals for Protection. Both are short (16 and 27 pages respectivel) Sex Type Socialization and Television Family Comedy Programs by Patricia Edgar (50 pp., $1.00) Families without Television by Patricia Edgar and Ray Crooke (137 pp., $2.50) Autocracy on the Airwaves by David Griffiths (65 pp., $2.50) The Cinematic Synthesis by Ian Mills (20 pp., price not given) Allan Brown's Australian Media Ownership (Department of Economics, University of Queensland, St. Lucia, Queensland, Aust. 4067—$2.60 including postage) Duncan Graham's Access to the Airwaves (Station 6NR, Western Australian Institute of Technology, Hayman Road, South Bentley, West Australia 6102—$2.45, paper)
Changes in obstructive sleep apnea severity, biomarkers, and quality of life after multilevel surgery (2010)

This multilevel surgery was associated with a low likelihood of response in subjects with body mass index >32 kg/m(2). Responders had decreased C-reactive protein levels that were independent of changes in body weight.
Taterschaft und Tatherrschaft (Authorship and Domination of Criminal Acts) (1971)

Journal Article Täterschaft und Tatherrschaft (Authorship and Domination of Criminal Acts) Get access TÄTERSCHAFTUND TATHERRSCHAFT (Authorship and Domination of Criminal Acts). (2d ed.). By Roxin Claus. Hamburger Rechtsstudien, Heft 50. Hamburg: de Gruyter, 1970. Pp. 661. M. André Rabie M. André Rabie *Research Scholar, University of Michigan Law School (February-April, 1970); Senior Lecturer, University of South Africa, Pretoria Search for other works by this author on: Oxford Academic Google Scholar The American Journal of Comparative Law, Volume 19, Issue 2, Spring 1971, Pages 372–376, https://doi.org/10.2307/839264 Published: 01 April 1971
Nucleic acid metabolism in the ruminant (1969)

1. Procedures, based on those of Schmidt & Thannhauser (1945) and Schneider (1945), for the extraction and estimation of nucleic acids in bovine digesta were examined in detail. 2. Final methods which were suitable for routine determination of RNA and DNA were essentially as follows. Digesta samples were extracted in the cold, first with a solution of trichloroacetic acid in ethanol, then with aqueous trichloroacetic acid solution and finally with lipid solvents. The dried residue was hydrolysed with alkali, purified by passage through a Dowex resin, and the RNA, in the form of mononucleotides, determined by U.V. absorption. DNA was determined separately in hot perchloric acid extracts of the original dried residue by colorimetric estimation of the deoxyribose content.
Observation of type-I and type-II Wannier-stark-effect in InGaAs/InGaAs superlattices (1993)

The formation of minibands is demonstrated in photocurrent experiments on shallow In0.53Ga0.47As/In0.40Ga0.60As superlattices grown by low pressure metal-organic vapor phase epitaxy. Field-dependent variations of the spectral shape are attributed to Wannier-Stark-localization. Both type-I transitions between electrons and heavy holes and type-II transitions involving light holes confined in the In0.40Ga0.60As layers are observed and identified by comparison with theoretical calculations of the superlattice electronic transitions.
Comparative Analysis of Antimicrobial Activities of Valinomycin and Cereulide, the Bacillus cereus Emetic Toxin (2011)

Cereulide and valinomycin are highly similar cyclic dodecadepsipeptides with potassium ionophoric properties. Cereulide, produced by members of the Bacillus cereus group, is known mostly as emetic toxin, and no ecological function has been assigned. A comparative analysis of the antimicrobial activity of valinomycin produced by Streptomyces spp. and cereulide was performed at a pH range of pH 5.5 to pH 9.5, under anaerobic and aerobic conditions. Both compounds display pH-dependent activity against selected Gram-positive bacteria, including Staphylococcus aureus, Listeria innocua, Listeria monocytogenes, Bacillus subtilis, and Bacillus cereus ATCC 10987. Notably, B. cereus strain ATCC 14579 and the emetic B. cereus strains F4810/72 and A529 showed reduced sensitivity to both compounds, with the latter two strains displaying full resistance to cereulide. Both compounds showed no activity against the selected Gram-negative bacteria. Antimicrobial activity against Gram-positive bacteria was highest at alkaline pH values, where the membrane potential (ΔΨ) is the main component of the proton motive force (PMF). Furthermore, inhibition of growth was observed in both aerobic and anaerobic conditions. Determination of the ΔΨ, using the membrane potential probe DiOC(2)(3) (in the presence of 50 mM KCl) in combination with flow cytometry, demonstrated for the first time the ability of cereulide to dissipate the ΔΨ in sensitive Gram-positive bacteria. The putative role of cereulide production in the ecology of emetic B. cereus is discussed.
Bi-doped fiber amplifiers and lasers [Invited] (2019)

Bismuth (Bi) doped fibers have shown promising potential for lasers and amplifiers in the 1150-1500 nm and 1600-1800nm wavelength region. Bi-doped aluminosilicate, phosphosilicate and germanosilicate fibers provide luminescence around 1150 nm, 1300 nm and 1450 nm, respectively. Recent results have demonstrated the possibility to extend the Bi luminescence window beyond 1600 nm using Bi-doped high (≥ 50 mol %) germanosilicate fibers. These spectral regions can serve a wide range of applications in medicine, astronomy, defense and to extend the optical fiber communication. However, Bi-doped fiber lasers and amplifiers are still far from their optimum performance owing to the unclear nature of the near-infrared emitting Bi active centers. In this paper, we review the current state of the art of Bi-doped silica fiber lasers (CW and pulsed) and amplifiers in different wavelength bands. Also, we present our work on the development of Bi-doped aluminosilicate and phosphosilicate fiber lasers and amplifiers in the 1180 nm and 1330 nm bands. These lasers and amplifiers find applications in generating visible light sources and to access the second telecommunication window. The fibers used here were fabricated by modified chemical vapor deposition-solution doping technique and characterized for their unsaturable loss. Moreover, we present the influence of pump wavelengths on the gain, noise figure and laser efficiency of these Bi-doped fiber amplifiers and lasers. We also discuss Bi-doped fibers for pulsed laser application and demonstrate a mode-locked Bi-doped fiber laser operating at 1340 nm.
Transfer of Halomonas canadensis and Halomonas israelensis to the genus Chromohalobacter as Chromohalobacter canadensis comb. nov. and Chromohalobacter israelensis comb. nov.. (2001)

16S rRNA gene sequence comparisons and DNA-DNA hybridization data support the conclusion that two species previously described as members of the genus Halomonas, Halomonas israelensis and Halomonas canadensis, should be placed in the genus Chromohalobacter. Both H. israelensis ATCC 43985T (= Ba1T) and H. canadensis ATCC 43984T (= NRCC 41227T) have been used extensively for physiological studies for many years; nevertheless, they were not named and classified taxonomically until quite recently. Their phenotypic resemblance (at least 65% Jaccard similarity) to some members of the genus Halomonas and the degree of DNA-DNA relatedness (lower than 60%) to other described species of this genus permitted the conclusion that they were distinct species belonging to the genus Halomonas. In this study, the 16S rDNA of both species has been sequenced completely and found to share higher similarity to the available sequences of the moderately halophilic bacterium Chromohalobacter marismortui than to sequences of members of the genus Halomonas. C. marismortui is the sole species of the genus Chromohalobacter, also included in the family Halomonadaceae, and shares many phenotypic features with H. canadensis and H. israelensis. It is proposed that the two species should be renamed as Chromohalobacter canadensis comb. nov. and Chromohalobacter israelensis comb. nov. An emended description of the genus Chromohalobacter is given in order to include the features of these two species.
ChemInform Abstract: Carbonic Anhydrase Inhibitors: Synthesis and Inhibition of the Human Cytosolic Isozymes I and II and Transmembrane Isozymes IX, XII (Cancer‐Associated) and XIV with 4‐Substituted 3‐Pyridinesulfonamides. (2010)

Abstract The pyridine‐derived sulfonamides (amines, ethers, hydrazines and sulfides) are investigated as inhibitors of five isoforms of zinc enzyme carbonic anhydrase.