gebhart/patrepeval huggingface dataset:
Quantitative and Comparative Profiling of Protease Substrates through a Genetically Encoded Multifunctional Photocrosslinker (2017)

A genetically encoded, multifunctional photocrosslinker was developed for quantitative and comparative proteomics. By bearing a bioorthogonal handle and a releasable linker in addition to its photoaffinity warhead, this probe enables the enrichment of transient and low-abundance prey proteins after intracellular photocrosslinking and prey-bait separation, which can be subject to stable isotope dimethyl labeling and mass spectrometry analysis. This quantitative strategy (termed isoCAPP) allowed a comparative proteomic approach to be adopted to identify the proteolytic substrates of an E. coli protease-chaperone dual machinery DegP. Two newly identified substrates were subsequently confirmed by proteolysis experiments.
SEREMOS 126 MILLONES EN EL ANO 2000 (1977)

URGENTE PLANIFICAR COMO HABRA DE DISTRIBUIRSE EN EL TERRITORIO NACIONAL, ESTO LO SENALO JAIME LUNA TRAIL, DIRECTOR GENERAL DE PLANEACION TERRITORIAL Y Y COORDINADOR DEL CURSO SOBRE ASENTAMIENTOS HUMANOS LLEVADO A CABO EN EL CENTRO DE EDUCACION CONTINUA DE LA DIVISION DE ESTUDIOS SUPERIORES DE INGENIERIA.DEBEN BUSCARSE SOLUCIONES PARA DISMINUIR EL RITMO DE CRECIMIENTO ORIGINADO POR LA MIGRACION DE LA ZONAS RURALES A LAS GRANDES CIUDADES.ES NECESARIO, SUBRAYO QUE SE FORMULE UN PLAN NACIONAL DE DESARROLLO URBANO PARA DESCENTRALIZAR CIERTAS ZONAS SATURADAS Y AL MISMOTIEMPO, BUSCAR SOLUCIONES A LA DISPERSION DE LOS PEQUENOS POBLADOS EN EL MEDIO RURAL. INDICO QUE LOS PROBLEMAS DE CENTRALIZACION DE MAS GRABEDAD SE HALLAN EN EL DISTRITO FEDERAL Y LA ZONA METROPOLITANA DE GUADALAJARA Y MONTERREY.
Carbohydrates of Living Tissues (1962)

portant members of the group, the gangliosides and cerebrosides, are described in detail.
Layout optimization of ESD protection TFO-NMOS by two-dimensional device simulation (2002)

The first-pass design methodology of ESD protection TFO-NMOS device has been developed using 2D process and device simulation. The ranges of optimum layout parameters have been suggested by investigating the current-to-failure and time-to-failure profiles extracted from 2D electro-thermal mixed-mode device simulation results.
ALLERGIC NEURITIS: AN EXPERIMENTAL DISEASE OF RABBITS INDUCED BY THE INJECTION OF PERIPHERAL NERVOUS TISSUE AND ADJUVANTS (1955)

In experimental allergic encephalomyelitis (EAE), produced by injecting rabbits with whole rabbit spinal cord together with tubercle bacilli and mineral oil, lesions comparable to those seen in the central nervous system are found in the nerve roots, spinal ganglia, and peripheral nerves. When special fractions of bovine white matter are used as antigen in rabbits, the same distribution of lesions is seen but peripheral nerve involvement is relatively less frequent. When rabbit sciatic nerve or spinal ganglia are used as antigen in rabbits, lesions occur only in the roots, ganglia, and peripheral nerves. Lesions are not produced in the central nervous system, nor is there a meningitis. This disease picture has been called experimental allergic neuritis (EAN). The antigenicity of rabbit nerve is not impaired by autoclaving. Sciatic nerve of other mammalian species produces the same disease in rabbits as does rabbit nerve. Optic nerve, used as antigen, produces the typical picture of EAE, not EAN. The optic nerves are not affected in EAN, whereas they commonly contain lesions in EAE. There are differences of symptomatology, referable to the difference in distribution of lesions, between EAE and EAN. The spinal fluid of EAE shows an increase both in the number of cells and in the total protein content. In EAN, the same changes in protein are observed, but usually the cell count remains normal. The cell count appears to be related to the involvement of cerebral and spinal meninges, which is an almost invariable accompaniment of EAE. The skin tests and serologic studies made with homologous and heterologous antigens were essentially non-contributory, apparently as a consequence of the diversity of antigens present in the inoculated materials. The similarity between EAN and certain of the human polyneuritides is indicated and discussed.
Paleolithic Nutrition (1985)

HUMANITY has existed as a genus for about 2 million years, and our prehuman hominid ancestors, the australopithecines, appeared at least 4 million years ago (Table 1). This phase of evolutionary history made definitive contributions to our current genetic composition, partly in response to dietary influences at that time. The foods available to evolving hominids varied widely according to the paleontological period, geographical location, and seasonal conditions, so that our ancestral line maintained the versatility of the omnivore that typifies most primates. Natural selection has provided us with nutritional adaptability; however, human beings today are confronted with diet-related health problems . . .
A unique rodent model for both the cardiotoxic and hepatotoxic effects of prolonged iron overload. (1993)

Repeated parenteral injections of iron dextran to gerbils resulted in hemochromatosis affecting the liver and heart with a pathology which is the same as occurs in the end-stage disease in man. This model will allow the detailed study of the mechanism of iron induced, free radical tissue damage, which is though to be the cause of these lesions and will also be useful in the evaluation of iron chelating therapies to determine whether the hepatic and cardiac pathology of iron overload can be modulated over a long period.
What is the best induction regimen for acute myelogenous leukemia? (1998)

The pursuit of the best induction regimen for acute myelogenous leukemia (AML) continues in an attempt to improve complete response rates and long-term disease free and overall survival. At this time, standard induction therapy generally consists of an anthracycline, most commonly daunorubicin given at a dose of 45-60 mg/m2 intravenously for 3 days and cytarabine arabinoside (ara-C) given at a dose of 100-200 mg/m2 intravenously by continuous infusion for 7 days. This regimen is based on findings from classic studies conducted from the late 1960s through the 1980s. Research on intensifying induction therapy has continued over the past decade. Potential strategies for intensifying induction therapy include (1) modulation of the anthracycline dose or agent; (2) modulation of ara-C; (3) the addition of other agents to standard induction therapy; (4) timed-sequential therapy; and (5) very early intensification therapy. Accurate interpretation of results from studies of intensifying induction therapy requires consideration of variables such as patient age, study inclusion criteria (eg, antecedent myelodysplasia), supportive care and, most importantly, patient selection. Furthermore, any benefit in long-term outcome during induction cannot be determined without regard to the choice of postremission therapy.
Smile and (Half) the World Smiles with You, Frown and You Frown Alone (1991)

The facial expression responses of adults to the display of facial expressions were examined in a variety of public settings to test predictions from a contagion hypothesis, that the display of smiles and frowns results in smiles and frowns, and folk wisdom that the display of a smile will result in a smile but that a frown will not lead to a frown in response. It was also predicted that female subjects would smile more frequently than male subjects and that people would smile at females more than at males. The results supported the folk adage rather than the contagion hypothesis: Over half the subjects responded to a smile with a smile, whereas few subjects responded to a frown with a frown. The predicted effects of subjects' and displayers' gender were also observed. The results were interpreted in the context of internalized norms of reciprocity for brief encounters. The potential for enhanced affect as a result of the contagion of smiles is discussed.
RET and Anisotropy Measurements Establish the Proximity of the Conserved Trp17 to Ile98 and Phe99 of Tear Lipocalin (2002)

Previous studies suggest that the conserved Trp17 on strand A of TL has a role in lipocalin stability and interacts, directly or indirectly, with Ile98 and Phe99 on strand G to influence ligand binding. Here, we determined the proximity of Trp17 to Ile98 and Phe99. Time-resolved fluorescence experiments showed resonance energy transfer between tryptophans at positions 17 and 98. In addition, an exciton effect was discovered in CD experiments resulting from interactions of the excited states of these tryptophans. Fluorescence anisotropy values of mutants containing two tryptophans (positions 99/17 and 98/17) were lower than expected in the absence of RET, confirming that these residues are proximate in tear lipocalin. The data support a model of tear lipocalin in which Trp17 and Phe99 are close together deep in the cavity and participate in an internal hydrophobic cluster. Ile98 is proximate to Trp17 but faces toward the outside of the cavity and in the model is part of an external hydrophobic patch. Comparison with beta-lactoglobulin suggests that these motifs may have an important influence on protein stability and ligand binding in other members of the lipocalin family.
DDT RESISTANCE IN THE HOUSEFLY CAUSED BY MICROSOMAL DEGRADATION (1968)

In vitro microsomal detoxication of DDT was studied in five strains of houseflies. One of these, Fc, is resistant to DDT and diazinon, and this resistance can be overcome by sesamex. Microsomes of this strain degraded DDT at a rate of 0.5 μg per fly per hour to at least four products of higher polarity. Resistance in this strain is due to a gene on the 3 rd chromosome, which we have called DDT‐md (microsomal detoxication). Evidence is presented that some of the products from DDT are produced in more than one step, and that primary and secondary reactions occur in microsomes of strain Fc only and are CO sensitive. In the other strains tested there was only a much lower rate of detoxication. No evidence was found in Fc flies of an increased detoxication by microsomal induction with DDT. Zusammenfassung DURCH MIKROSOMALEN ABBAU HERVORGERUFENE DDT‐RESISTENZ BEI DER STUBENFLIEGE Entgiftung von DDT durch Mikrosomen in vitro wurde bei 5 Stubenfliegen‐Stämmen studiert. Einer von ihnen, Fc, ist resistent gegen DDT und Diazinon; diese Resistenz kann durch Sesamex überwunden werden. Mikrosomen dieses Stammes bauten DDT mit einer Rate von 0,5 mg pro Fliege und Stunde zu wenigstens 4 Produkten höherer Polarität ab. Die Resistenz beruht in diesem Stamme auf einem Gen im dritten Chromosom, welches wir DDT‐md (microsomal detoxication) genannt haben. Es wird wahrscheinlich gemacht, daß einige der Produkte aus DDT in mehr als einem Schritt erzeugt werden und daß primäre und sekundäre Reaktionen nur in Mikrosomen des Fc‐Stammes auftreten und CO‐empfindlich sind. In anderen geprüften Stämmen ergab sich nur eine geringere Entgiftungsratc. In Fc‐Fliegen war kein Nachweis für eine verstärkte Entgiftung durch mikrosomale Induktion mit DDT zu erbringen.
FACE-UP CHEMICAL MECHANICAL POLISHING: KINEMATICS AND MATERIAL REMOVAL RATE (2006)

A working prototype face-up CMP tool has successfully been completed. Experiments conducted on the face-up CMP machine qualitatively correspond with the theoretical polishing model. Discrepancies in data from the theoretical model could potentially be caused by non-uniform loading of the polishing pad and uneven distribution of slurry over the pad due to the edge effects on fluid flow. Despite the discrepancies, experimental data suggest that the theoretical model used to describe blanket wafer polishing by theface-up CMP tool is at least partially valid. Thesis Supervisor: Dr. Jung-Hoon Chun Title: Professor of Mechanical Engineering Thesis Supervisor: Dr. Nannaji Saka Title: Research Affiliate, Department of Mechanical Engineering
Kinetics and mechanism of interactions between iron(lll) and desferrioxamine B. The formation and hydrolysis of ferrioxamine B in acidic aqueous solution (1983)

The kinetics of the formation and hydrolysis of ferrioxamine
B complexes have been studied in acidic aqueous solution (0.001-
-1.0 M HCl) at 25.0 °c, μ = 1.0 M (maintained by NaCl). Two stage
kinetics have been observed in both the formation and in the hydrolysis
reactions. The proposed reaction model involves formation/
hydrolysis of bidentate, tetradentate, and hexadentate bonded
desferrioxamine B to iron(III).
The formation of the bidentate complex occurs by two paths:
one involving unhydrolysed ferric ion yields the rate constant
k1 = 282 M-1 s-1, and the other via hydrolysed ferric species gives
the rate constant k1' = 4.1 X 103· M-1 s-1• The analogous rate constants
for the reverse hydrolysis reactions were obtained; k - 1 =
= 0.65 M-1 s-1 for the acid dependent and k _ 1' = 0.016 s·1 for the
acid independent path.
The formation and hydrolysis rate constants of the tetradentate
linked complex have been calculated using the steady-state approximation
as k 2 = 9 s·1 and k _2 = 2 M-1 s-1, respectively.
The conversion of tetradentate to hexadentate as well as
hydrolysis of the hexadentate to tetradentate bonded species have
been characterized by the rate constants k 3 = 2.2 s-1 and k _ 3 =
= 18 M-1 s-1, respectively.
These results are compared with kinetic data previously
reported. Chloride media increases the rate of formation and hydrolysis
of the bidentate species, and possibly has the same effect
on the tetradentate species but does not affect hydrolysis of the
hexadentate complex. These effects were analyzed in terms of a
labilization of iron(III) coordinated ligands by inner-sphere coordinated
chloride.
Acoustic measurements of the X-wing rotor (1983)

Noise measurements of a stoppable X-wing rotor system model, tested in the Ames 40- by 80-foot wind tunnel, are summarized. Performance, control system stability, and noise of the model were investigated at various forward speeds, tip speeds, collective blade angles, jet blowing velocities, and model attack angles. The model was tested in the rotating wing helicopter configuration, in the fixed wing configuration, and in wing configurations between the two. Noise data obtained in the helicopter configuration at the two highest tip speeds (Mach 0.44 and 0.47) and at wind tunnel speeds below 140 knots are reported. Test configuration and performance information are included. General acoustic measurements (dB, dBA, and PNdB) at six microphone locations are presented for all conditions under which the background noise was below the model noise. More specific measurements (1/3-octave and blade passage frequency harmonic levels) are presented for selected conditions. Graphs of dBA and 1/3-octave spectra, which show the noise trends as functions of operating condition, are included. The noise depends mainly on the jet blowing velocity. The noise levels were highest at moderate jet blowing velocities, less at the highest velocity, and lowest with no blowing at all.
Richard Henry Dana, Jr. and Two Years before the Mast: Strategies for Objectifying the Subjective Self (1987)

One of most curious uses of a literary text has been em ployment of excerpts from Two Years before Mast for vision tests at optometrist's office. And a fine irony emerges when we consider that book itself grew out of a young Harvard student's service on a merchant vessel in order to restore his failing eyesight an entire change of life, and by a long absence from books and study.1 What was, in event, a journey for improvement of one man's vision has become, in writing, test of another's sight. But that irony is not simply product of history's uncanny machinations—it stems from a widely-held notion about Dana's prose style. Writing in 1955, John T. Winterich praised Dana for the rare gift of simple, straightforward, lucid utterance. He is one of few writ ers who are completely understandable. ... Is it any wonder that even today extracts from Two Years before Mast are used by ophthalmologists and optometrists? Go to your eyeman and take a test—you will be reading a that neither dismays dullard nor patronizes intellectual.2 The implication here is that Dana's prose functions as a pure and unclouded referential language in which events or objects and their verbal representations become virtually synonymous—that Dana's language succeeds so fully as a colorless and undistorting medium for presenting physical reality that his words may be used as a test of one's vision. Any misreading of Dana's universal English would denote a blank in patient's eye rather than a stylistic obfuscation of plain fact in text. Yet there may be a little lower layer to stylistic paradigm sug gested by optometrist's office. In vision test usual roles of subject and object are reversed—the patient looks at text not to gauge it, but to be gauged by it. And even though it is mere me chanical operation of eye that would concern us here, notion of I who is implied by exercise of eye—the self as
Palladium‐Catalyzed Direct Dialkenylation of Cage BH Bonds in <i>o</i>‐Carboranes through Cross‐Coupling Reactions (2015)

Palladium-catalyzed direct dialkenylation of cage B(4,5)-H bonds in o-carboranes has been achieved with the help of a carboxylic acid directing group, leading to the preparation of a series of 4,5-[trans-(ArCH=CH)]2-ocarboranes in high yields with excellent regioselectivity. The traceless directing group, eliminated during the course of the reaction, is responsible for controlling regioselectivity and dialkenylation. A possible catalytic cycle is proposed, involving a tandem sequence of Pd(II) -initiated cage B-H activation, alkene insertion, β-H elimination, reductive elimination, and decarboxylation.
Interfacing, often a performance bottleneck between ATE and device under test (2003)

Problems in adapting the interface of VLSI test systems to the device under test (DUT) are reviewed. The focus is on efforts to avoid the electrical degradation of the DUT, especially with increasing operating speeds and increasing pincounts. The channel cards or pin electronics of the automatic test equipment (ATE) have to be flexible and as close to the DUT as possible, and the electromechanical interface, known as the device interface board (DIB) or loadboard, has to be of high quality. For an ATE of given and known performance, the final results therefore very often depend on the performance of such DIBs. Variations of test results caused by wiring on the DIB may decrease the total yield or let the device get binned into a lower category. In the production test areas, there is an inherent tendency to save costs and hence use a so-called 'mother-daughter' board concept for DIBs. For slower NMOS devices and generally for devices with uncritical timing, this concept is acceptable. However, for modern CMOS devices with fast switching outputs, the insertion of pogo pins in the transmission line and the availability of fewer pins for the ground connections could severely degrade the performance of testing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Theory of modified cylindrical mirror electron spectrometer free of third-order aberration (1980)

The equations of motion of electrons emitted by a point source on the axis of symmetry of a modified cylindrical mirror are solved. The modification consists of the addition of a third concentric cylindrical electrode, placed between the inner and outer cylinders. It is shown that for a suitable choice of parameters the third-order angular aberration of the modified instrument can be eliminated. The consequences of this change on the energy resolution, transmission and dispersion of the instrument are analysed, and compared with the corresponding properties of a conventional cylindrical mirror spectrometer. For a given energy resolution limited by angular aberration, the transmission of the new instrument is significantly larger than that of the new instrument is significantly larger than that of the conventional one.
Organic matter and nitrogen digestion by dairy cows fed calcium salts of rapeseed oil fatty acids or rapeseed oil1 (1993)

The aim of this experiment was to study the effects on digestion of a supply of Ca salts of vegetable oil as a fat source for ruminants. Total tract digestibility and ruminal digestion were studied using three ruminally and duodenally fistulated dairy cows in a Latin square design. Diets compared were a control diet (C) based on corn silage and concentrate, and the C diet supplemented with calcium salts of rapeseed oil (S) or supplemented with rapeseed oil (O). Organic matter digestibility was lower (P < .05) for diet O than for diet C; diet S was intermediate and not different (P > .05) from diet C. Treatment did not affect (P > .05) the proportion of OM digested in the rumen, total N and microbial N flow at the duodenum, or efficiency of N microbial synthesis. In situ degradation of DM and NDF was higher for diet S than for diet C. The molar concentration of ruminal acetate was lower (P < .05) for O than for C and S. Under the conditions of this trial, supplemental calcium salts rich in polyunsaturated fatty acids did not decrease ruminal digestion.
Comparison of ligase chain reaction and culture for detection of Neisseria gonorrhoeae in genital and extragenital specimens (1997)

In addition to the urogenital tract, Neisseria gonorrhoeae infects extragenital sites such as the pharynx and anorectal canal. Culture and a ligase chain reaction (LCR)-based assay were compared for their performance for the diagnosis of N. gonorrhoeae infection with specimens from various urogenital and extragenital sites of 200 men and 125 women. The sensitivity and specificity of the LCR assay with male urethral swabs were both 100%, compared to values of 95.9 and 100%, respectively, for culture of urethral swabs or 98.0 and 100%, respectively, for LCR with first-void urine (FVU). For women, LCR with FVU showed the highest sensitivity (94.7%), and culture of urethral samples showed the lowest sensitivity (63.2%) (P < 0.05). In a selected subgroup of 47 men and 22 women at increased risk, the rates of pharyngeal infection were 15 and 18%, respectively, and those of anorectal infection were 13 and 45%, respectively. The sensitivity of LCR was greater than that of culture for both pharyngeal and anorectal specimens. Thus, the overall performance of LCR testing with swabs or FVU was better than that of culture for the diagnosis of genital or extragenital gonorrhea.
Deep level transient spectroscopy study of the damage induced in n-type silicon by a gate oxide etching in a CHF3/Ar plasma (1997)

Deep level transient spectroscopy was used to detect the presence of deep levels correlated to the defects induced in the Si substrate by a CHF3/Ar dry etch of a 550 Å gate oxide as a function of the rf power. Several energy levels were observed; some of them were due to the processing before the dry etching. Three traps produced by the dry etching, with Arrhenius plot activation energies, respectively, Ena1=350 meV, Ena2=220 meV, and Ena3=100 meV, and capture cross sections around 10−20 cm2 were detected. The correlation with the surface recombination velocity variations and the F and C diffusion in the Si substrate was investigated.
Use of Fat-Modified Foods for Serum Cholesterol Reduction (1963)

Dietary modification designed to reduce blood cholesterol concentrations usually requires detailed instruction and a restricted intake of many foods. In this study commercially prepared, fat-modified foods were supplied to young adults for 10 months. The altered foods were low in saturated fat and, in some, the "hard" fats were replaced with poly-unsaturated oils. Individual diet instruction was not given. The average reduction in serum cholesterol was 14%. Thus, significant hypocholesterolemic effects were obtained with suitably modified, palatable foods. This type of diet modification required little diet instruction and may prove to be a practical method for clinical and research use.