gebhart/patrepeval huggingface dataset:
Abstract 4432: A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo (2015)

Abstract ABCG2 is a member of the ABC transporter superfamily, which has been implicated in the development of multidrug resistance (MDR) in cancer. Its diverse range of substrates includes many antineoplastic agents such as topotecan, doxorubicin and mitoxantrone. ABCG2 expression has been significantly increased in some solid tumors and hematologic malignancies, which is correlated to poorer clinical outcomes. In addition, ABCG2 expression is a distinguishing feature of cancer stem cells, whereby this membrane transporter impacts resistance to the chemotherapeutic drugs. To enhance the chemosensitivity of cancer cells, attention has been focused on MDR modulators. In this study, we investigated the ability of a tetrodotoxin-resistant sodium channel blocker, A-803467 to reverse ABCG2-mediated MDR. We found that A-803467 at non-toxic concentration could significantly increase the cellular sensitivity to ABCG2 substrates in drug-resistant cells overexpressing either wild-type or mutant ABCG2. Mechanistic studies indicated that A-803467 (7.5 μM) significantly increased the intracellular accumulation of mitoxantrone by inhibiting the transport activity of ABCG2, without altering its expression level. In addition, A-803467 stimulated the ATPase activity of ABCG2 in a concentration-dependent manner, indicating that A-803467 might be a substrate of ABCG2. Binding interactions of A-803467 were found to be in transmembrane region of homology modeled human ABCG2. Interactions of A-803467 with ABCG2 were relatively stronger when compared to the interactions of topotecan with ABCG2. Furthermore, A-803467 (30 mg/kg) with topotecan (3 mg/kg) significantly decreased the growth rate and tumor size of ABCG2 overexpressing tumors in a xenograft nude mouse model. Our findings indicate that A-803467 has the potential to be used in combination with ABCG2 chemotherapeutic substrates to improve the response in drug resistant cancers. Citation Format: Nagaraju Anreddy, Atish Patel, Yun-Kai Zhang, Yi-Jun Wang, Suneet Shukla, Rishil J. Kathawala, Priyank Kumar, Pranav Gupta, Suresh V. Ambudkar, John ND Wurpel, Zhe-Sheng Chen. A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4432. doi:10.1158/1538-7445.AM2015-4432
Distribution of the T4D Bacteriophage Binding Sites on the Escherichia Coli B Surface (1983)

A study of the distribution of the T4D bacteriophage binding sites on the Escherichia coli B bacterial surface has shown that: (1) the number of binding sites per unit surface area is larger during growth period than during the division period, (2) the density of the binding sites on one-half of the bacterial cell is larger than the density of binding sites on the other half; (3) in newly-divided bacteria, the maximal binding site density is situated at one pole; (4) as bacteria grow, this maximum shifts to the middle of the cell; (5) when the septum is established, the middle of the cell becomes very poor in phage binding sites activity, and (6) phage adsorbs in clusters or in groups following curved lines around the bacterial cell.
Inter- and Intra-Laminar Distribution of Tectospinal Neurons in 23 Mammals (1993)

Based on retrograde labeling from the high cervical spinal cord, the inter- and intra-laminar distributions of tectospinal tract (TST) somata within the tectum of 23 mammals and one reptile are described. The results show that TST somata are found only in the intermediate and deep layers. Although more TST somata are usually found in the intermediate layer, there are no useful relationships for predicting the number in one layer given the number in the other. The ratio of numbers of TST somata in the intermediate relative to the deep layer varies widely, from 0:1 (in rabbits) to over 8:1 (in marmosets). Within both layers the majority of TST somata (> 80%) are found in the lateral half of the tectum--the area subversing the lower visual field. In contrast, the variation between temporal and nasal visual fields is adequately accounted for by the animal's 'visual axis'--the azimuth of its field of best vision. In general, the present results uphold the idea that the significance of the TST somata, and perhaps of the tectospinal tract itself, is to be found in directing the head so that the retinal area of best vision can be brought to bear on stimuli either almost outside, or about to pass outside, of the area of best vision. The larger and possibly universal predominance of TST somata subserving the lower visual field suggests that the tectospinal tract may be primarily concerned with adjusting the step dimensions of the forelegs to accommodate obstacles to normal progression.
Numerical simulation of the fast dense gas Ludwieg tube experiment (2006)

The preliminary design of a Ludwieg tube experiment for the verification of the existence of nonclassical rarefaction shock waves in dense vapors is here critically analyzed by means of real gas numerical simulations of the experimental setup. The Flexible Asymmetric Shock Tube (FAST) setup is a dense gas Ludwieg-type tube in which a rarefaction shock is produced after the opening of the valve separating the reservoir from the charge tube. Quasi-onedimensional simulations of the FAST experiment are presented to support the current design of the experiment. Simulations are performed using the CFD software zFlow linked to the appropriate thermodynamic libraries that implement newly developed thermodynamic models. Off-design situations are also investigated numerically and include uncertainties related to thermodynamic modeling, the possibility of using different fluids and the sensitivity to a small change in the nozzle throat section. The preliminary design is confirmed to be feasible and constructions requirements are found to be well within technological limits.
Chemistry of the sulfur-nitrogen bond. VIII. N-Alkylidenesulfinamides (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of the sulfur-nitrogen bond. VIII. N-AlkylidenesulfinamidesFranklin A. Davis, Arthur J. Friedman, and Edward W. KlugerCite this: J. Am. Chem. Soc. 1974, 96, 15, 5000–5001Publication Date (Print):July 1, 1974Publication History Published online1 May 2002Published inissue 1 July 1974https://pubs.acs.org/doi/10.1021/ja00822a055https://doi.org/10.1021/ja00822a055research-articleACS PublicationsRequest reuse permissionsArticle Views690Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In Vitro Effects of a C4‘-Oxidized Abasic Site on DNA Polymerases (2004)

Oxidative damage to DNA produces abasic sites resulting from the formal hydrolysis of the nucleotides' glycosidic bonds, along with a variety of oxidized abasic sites. The C4'-oxidized abasic site (C4-AP) is produced by several DNA-damaging agents. This lesion accounts for approximately 40% of the DNA damage produced by bleomycin. The effect of a C4'-oxidized abasic site incorporated at a defined site in a template was examined on Klenow fragments with and without 3' --> 5' exonuclease activity. Both enzymes preferentially incorporated dA > dG >> dC, T opposite C4-AP. Neither enzyme is able to extend the primer past the lesion. Experiments with regular AP sites in an otherwise identical template indicate that Klenow does not differentiate between these two disparate abasic sites. Extension of the primer by alternative polymerases pol II, pol II exo(-), pol IV, and pol V was examined. Pol II exo(-) was most efficient. Qualitative translesion synthesis experiments showed that pol II exo(-) preferentially incorporates T opposite C4-AP, followed in order by dG, dA, and dC. Thymidine incorporation opposite C4'-AP is distinct from the pol II exonuclease interaction with a regular AP site in an otherwise identical template. These in vitro experiments suggest that bypass polymerases may play a crucial role in survival of cells in which C4-AP is produced, and unlike a typical AP site, the C4-AP lesion may not follow the "A-rule". The interaction between bypass polymerases and a C4-AP lesion could explain the high levels of G:C --> T:A transversions in cells treated with bleomycin.
Research on Large Adaptive Arrays. (1979)

Abstract : Most adaptive filters are designed to achieve minimization of estimation error. Other design goals could include satisfaction of constraints as well as minimization of mean square error. The paper proposes a particular set of performance criteria, involving 'soft constraints'. A 'soft-constraint LMS algorithm' is derived from a performance function which is the sum of mean square error and weighted squared constraint violation errors. The soft constraint algorithm is applied to adaptive antenna arrays as an example, which includes a demonstration of the effects of varying the softness of the constraints. Also, convergence properties of the algorithm are presented. A relation between the output power of a signal from a converged soft constraint LMS adaptive filter and the signal's input power is derived, which demonstrates some unexpected behavior. (Author)
Contribution of aerosol deposition to atmospheric deposition and soil loads onto forests (1994)

Deeltjes depositie op bos is bestudeerd waarbij gebruik
 is gemaakt van experimentele en model resultaten. Resultaten tonen aan dat
 de depositie van deeltjes op bossen tot nu toe is onderschat. Deeltjes
 depositie levert een belangrijke bijdrage aan de totale depositie van
 verzurende componenten en basische kationen op bossen. Beraamd was dat op
 het Speulderbos de bijdrage van droge deeltjes depositie aan de totale
 depositie was 18% voor SO4, 38% voor NO3, 23% voor NH4, 56% voor Na, 47%
 voor K, 69% voor Ca en 65% voor Mg. Depositie van verbindingen door middel
 van smog op het Speulderbos was klein geschat (<5%). Resultaten van de
 kroonuitwisselingsprocessen op Speulderbos en van de vergelijking van
 atmosferische depositieschattingen en doorvalschattingen op Speulderbos
 tonen aan dat netto doorval fluxen en atmosferische droge
 depositieschattingen redelijk in overeenstemming zijn voor alle componenten,
 behalve nitraat. Er is nog steeds grote onzekerheid in
 kroonuitwisselingsprocessen voor geoxideerd stikstof en in de
 depositieschattingen van de diverse gassen die bijdragen aan de totaal
 geoxideerd nitraat fluxen.
Inflation Risk, Learning Mechanism and Strategic Asset Allocation (2011)

Campbell and Viceira (2001) were the first to incorporate inflation risk into the optimal portfolio problem and found that the investor decreased the holding weights of long term bonds in the absence of inflation-linked underlying assets. Xia (2001) found that opportunity cost was significantly substantial when investors ignored the learning mechanism of uncertainty parameters and used the learning method to predict the parameter of the dynamics of stock price. In this study, we not only show that the learning process increases the utility value of terminal wealth, but also analyze the effect of learning process on the expected utility value of terminal wealth. The results are as follows.
1. Investment horizon, instantaneous volatility of inflation rate and risk attitude positively affects the learning process on the terminal wealth and its expected utility. The effects are more significant when the investment horizon, volatility and risk-averse attitude increase.
2. When volatility of the consumer price index and the estimation error increase, the learning ability enhance the expected wealth and utility. However, the improvement rate of utility decrease since investors becomes hardly learn from the inflation rate.
Key words: Time horizon, expected utility, volatility, risk averse, improvement rate
HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control (2019)

Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I molecules has repeatedly been associated with HIV-1 control and progression to AIDS, accounting for up to 12% of the variation in HIV-1 set point viral load (spVL). This suggests a key role in disease control for HLA presentation of HIV-1 epitopes to cytotoxic T cells. However, a comprehensive understanding of the relevant HLA-bound HIV epitopes is still elusive. Here we describe a peptidome-wide association study (PepWAS) approach that integrates HLA genotypes and spVL data from 6,311 HIV-infected patients to interrogate the entire HIV-1 proteome (3,252 unique peptides) for disease-relevant peptides. This PepWAS approach predicts a core set of epitopes associated with spVL, including known epitopes but also several previously uncharacterized disease-relevant peptides. More important, each patient presents only a small subset of these predicted core epitopes through their individual HLA-A and HLA-B variants. Eventually, the individual differences in these patient-specific epitope repertoires account for the variation in spVL that was previously associated with HLA genetic variation. PepWAS thus enables a comprehensive functional interpretation of the robust but little-understood association between HLA and HIV-1 control, prioritizing a short list of disease-associated epitopes for the development of targeted therapy.
Le tatouage robuste, ou comment protéger les contenus visuels (2005)

Le développement de la stéganographie, de la cryptographie et du tatouage est une réponse aux nouveaux besoins de droits de propriété, d’identification, d’authentification, de confidentialité, et plus généralement de traçabilité en termes de protection des contenus. Cet article fait une présentation du tatouage au regard des deux autres méthodologies. Tout d’abord, il aborde ses concepts fondamentaux et ses propriétés, pour ensuite effectuer une analyse critique des méthodes de tatouage robuste.
Handover of media streams with network coding (2015)

Nowadays streaming media traffic has a significant share of the mobile data volume. In this paper we focus on the handover process of streaming media connections and propose a solution that improves the user experience by providing a resilient handover scheme. According to our proposal, before the mobile subscriber joins the new attachment point, the information is proactively distributed there, using network coding. Therefore the subscriber is able to collect the packets combined at the old and new attachment points. The method was evaluated by means of simulation.
Segmenting the Human Genome into Isochores (2015)

The human genome is a mosaic of isochores, which are long (>200 kb) DNA sequences that are fairly homogeneous in base composition and can be assigned to five families comprising 33%–59% of GC composition. Although the compartmentalized organization of the mammalian genome has been investigated for more than 40 years, no satisfactory automatic procedure for segmenting the genome into isochores is available so far. We present a critical discussion of the currently available methods and a new approach called isoSegmenter which allows segmenting the genome into isochores in a fast and completely automatic manner. This approach relies on two types of experimentally defined parameters, the compositional boundaries of isochore families and an optimal window size of 100 kb. The approach represents an improvement over the existing methods, is ideally suited for investigating long-range features of sequenced and assembled genomes, and is publicly available at https://github.com/bunop/isoSegmenter .
Improved Optical Instrument For The Measurement Of Water Wave Statistics In The Field (2011)

An improved optical instrument for the measurement of slope and height statistics of capillary and short gravity wind waves on the ocean has been built. This reflective stereo slope gauge (RSSG) is based on the work of Waas and Jahne (1992). It uses a dedicated stereo camera setup with a stereo infrared LED light source. Wave slope statistics can be derived from the observation of specular reflections and wave height from the parallax of the specular reflections in the stereo images. The instrument has been successfully tested in the Heidelberg Aeolotron.
DT-diaphorase of the amitochondriate parasite <i>Giardia lamblia</i>: A Biochemical and Structural Study (2000)

Conference Abstract| October 01 2000 DT-diaphorase of the amitochondriate parasite Giardia lamblia: A Biochemical and Structural Study L. B. Sánchez; L. B. Sánchez 1Laboratory of Biochemical Parasitology, The Rockefeller University, 1230 York Avenue, New York, NY 10021 Search for other works by this author on: This Site PubMed Google Scholar H. Elmendorf; H. Elmendorf 2Biology Department, Georgetown University, Washington, DC3Laboratory of Parasitic Diseases, NIAID/NIH, Bethesda MD Search for other works by this author on: This Site PubMed Google Scholar T. E. Nash; T. E. Nash 3Laboratory of Parasitic Diseases, NIAID/NIH, Bethesda MD Search for other works by this author on: This Site PubMed Google Scholar M. Müller M. Müller 1Laboratory of Biochemical Parasitology, The Rockefeller University, 1230 York Avenue, New York, NY 10021 Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A483. https://doi.org/10.1042/bst028a483c Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation L. B. Sánchez, H. Elmendorf, T. E. Nash, M. Müller; DT-diaphorase of the amitochondriate parasite Giardia lamblia: A Biochemical and Structural Study. Biochem Soc Trans 1 October 2000; 28 (5): A483. doi: https://doi.org/10.1042/bst028a483c Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Investigations in Heterocycles. IX. Resonance Effects in Pyrazolin-5-ones and Related Compounds (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigations in Heterocycles. IX. Resonance Effects in Pyrazolin-5-ones and Related CompoundsGeorge DeStevens, Angela Halamandaris, Patricia Wenk, and Louis DorfmanCite this: J. Am. Chem. Soc. 1959, 81, 23, 6292–6295Publication Date (Print):December 1, 1959Publication History Published online1 May 2002Published inissue 1 December 1959https://pubs.acs.org/doi/10.1021/ja01532a044https://doi.org/10.1021/ja01532a044research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Delayed effects of elevated corticosterone level on volume of hippocampal formation in laboratory rat (2010)

We studied delayed effects of elevated plasma levels of corticosterone (Cort) on volumetry, neuronal quantity, and gross marks of neurodegeneration in the hippocampal formation of Long-Evans rats. Animals were exposed to increased CORT levels for three weeks via implanted subcutaneous pellets. Volumetry, neuronal quantification and gross marks of degeneration were measured seven weeks after the termination of CORT treatment. We observed significant differences in volumes and especially in laterality of hippocampal subfields between control and CORTtreated animals. We found that the left hippocampus was substantially larger than the right hippocampus in the corticosterone-treated group, but not in the control group. In the control group, on the other hand, right hippocampal volume was markedly higher than all other measured volumes (hippocampal left control, hippocampal left CORT-treated and hippocampal right CORT-treated). Left hippocampal volume did not differ between the groups.
Cylinder Insertion into Hole of Flexible Rubber Plate - Insertion Force Related to Position and Posture of Cylinder - (1998)

We discuss cylinder insertion into a hole of a flexible rubber plate. Rubber plate deformation is modeled using long beams aligned perpendicular to the hole. Insertion force is analyzed in relation to cylinder depth, offset and inclination. Insertion force forms a hyperbolic field in three-dimensional space composed of position and posture parameter coordinates. The magnitude of insertion force is discussed based on insertion trajectory in the hyperbolic field. A human inserting a cylinder might angle it at the start of insertion, making it perpendicular to the rubber surface at the end. The human's sequence uses a trajectory that minimizes insertion force. We show experimentally a hyperbolic field in position and posture space.
Chemiluminescence‐Based Inhibition Kinetics of Alkaline Phosphatase in the Development of a Pesticide Biosensor (1995)

The use and application of the enzyme alkaline phosphatase in a chemiluminescence assay are discussed. The enzyme catalyzes the hydrolysis of a macrocyclic phosphate compound generating a chemiluminescence signal. On the basis of inhibition of this signal, a methodology for the detection and quantitation of organophosphorus-based pesticides has been developed. The methodology is studied with alkaline phosphatase in the bulk aqueous phase, and detection of the signal is accomplished by a simple optical setup. Parts per billion level detection of paraoxon and methyl parathion in bulk solutions is achieved. The technique is rapid and sensitive and is applicable to the detection of most organophosphorus-based pesticides. The results from kinetic studies indicate a mixed type of inhibition of the enzyme by paraoxon and methyl parathion. The detection methodology forms an integral part of a biosensor under development and is adaptable to incorporating optical fibers for remote detection of pesticides.