gebhart/patrepeval huggingface dataset:
Crystal structure of the histone tetramer from calf thymus (1984)

We report crystallographic data for a dinucleoside monophosphate d(T[plT) (as its cyanoethyl derivative) with the cis-syn cyclobutane geometry generated by UV irradiation. The molecule crystallizes in the orthorhombic space group P2 1 2 1 2 1 (Z = 4) with two '.;ater
In vivo three dimensional MRI of GL261 syngeneic gliomas concurrently with analysis of CNS infiltrating tumor-specific killer T cell responses (127.15) (2012)

Abstract Glioblastoma multiforme (GBM) is among the most lethal of cancers. Enhancing anti-tumor killer T cell responses via dendritic cell vaccines has correlated with a positive outcome in selected GBM patients. Nevertheless, the mechanisms by which killer T cell responses to GBM are inhibited or enhanced remain poorly defined. We therefore developed the GL261 “Quad Cassette” glioma cell line that expresses model T cell epitopes in the immunocompetent C57BL/6 mouse. Tumor size and inflammatory profiles observed in these animals was then compared to C57BL/6 mice administered the parent GL261 glioma cell line. Resulting tumors present with a tumor mass surrounded by considerable edema visible by gadolinium enhanced T1 and T2 weighted MRI. Both edema and tumor mass visible by MRI were quantified using Analyze 10.0 software which enables 3D volumetric analysis of MRI images. C57BL/6 mice with GL261 “Quad Cassette”, but not parent GL261 gliomas, presented with smaller tumor mass and significant brain infiltrating tumor specific Kb:ova specific CD8 T cells. We therefore conclude that the GL261 Quag Cassette system is suitable for studying tumor epitope specific CD8 T cell responses using the vast genetic and immunologic resources available for the C57BL/6 mouse background. Furthermore, incorporation of the first true 3D volumetric analysis of GL261 glioma size with small animal MRI will enable investigation of immunotherapeutic treatments in vivo without euthanizing the animal.
Generation, Growth and Collapse of a Bubble in Conductive Liquid Heated Directly by Electric Current. (1996)

Bubbles generated in conductive ink heated directly by electric current pulses can be used in an ink-jet printer to eject ink-droplets. Such parameters as the time required for bubble nucleation, growth rate of the bubble, maximum radius of the bubble and electric power input required for bubble generation, which depend strongly on the shape and size of electrodes immersed in the ink, influence the performance of the printer. A method of numerical analysis was developed to investigate the temperature distribution of the ink and dynamics of the bubble, and was confirmed to give values of the above parameters which were in good agreement with those of experiment. An optimum configuration of the electrodes was suggested, based on the comparison of results calculated for different shapes and dimensions of the electrodes.
Evaluation of cefoxitin prophylaxis for cesarean section (1981)

Prophylactic cefoxitin was evaluated in 101 patients undergoing cesarean section. A three-dose regimen of either cefoxitin or placebo was administered randomly in a double-blind manner, 46 patients receiving cefoxitin and 55 placebo, with the first dose given after the cord was clamped. In the placebo group, 29% of the patients developed pelvic or wound infection, compared to 4% in the cefoxitin group (P less than 0.003). No patient required re-operation, re-admission, or had a life threatening infection. Ten risk factors for infection were analyzed to help ascertain which patients would benefit from prophylaxis. Cefoxitin, with a broad spectrum of aerobic and anaerobic coverage, was found to be an effective and safe prophylactic agent when given to all patients undergoing cesarean section.
Charge-driven dispensing of picolitre drops for biomolecules microarrays by Pyro-Electro-hydrodynamic system (2013)

At present, most microfluidic technologies consist of microchannels where liquids are manipulated by changing pressures or electrode voltages but such systems suffer from different drawbacks such as complex fabrication, sample cross-contamination, high voltage or pressure requirements. Our work represents instead a new and simple system where the liquid actuation and dispensing has been achieved through electrode-free configurations using polar dielectric crystals such as lithium niobate (LN) and by exploiting the pyroelectric effect. This novel `Pyro-Electro-hydrodynamic' manipulation system could be used as a pioneering portable instrument for detecting in-situ even low concentrated analytes not detectable by traditional methods.
Acoustic spectrogram and complex-frequency poles of a resonantly excited elastic tube (1984)

We present a study of the resonance scattering undergone by an air-filled hollow elastic cylinder excited by an incident plane acoustic wave. We construct the boundary value problem, obtain its classical solution, the solution based on the Resonance Scattering Theory (RST), and generate a variety of useful computed results, some of which are later compared to experimental observations recently performed in France. We present highly accurate expressions for the phase and group velocities and for the phase and group attenuations of the first few surface waves circumnavigating (the extreme cases) of rigid and soft cylinders, and display these dispersion plots in all instances. We analyze the modal backgrounds and modal resonances of the shell, display them in a wide spectral band, determine the SEM-type pole-position diagram in the complex k1a plane, and obtain and display the background-suppressed cross section of the tube. This result serves to generate the acoustic spectrogram of the shell as well as to show the excellent agreement of this theoretical prediction with the experimental observations carried on in France. We analyze cross-sectional poles and cross-sectional dips, and reduce many of the present shell results to particular cases for impenetrable cylinders and solid elastic cylinders. For these latter ones, we obtain the dispersion plots for the phase and group velocities of the internal surface waves revolving around them. We determine expressions for the nearfield shell cross sections at different ranges, and compare them to the usual farfield results. We determine the sound pressure levels transmitted into the shell’s interior, and exhibit the controlling role the tube resonances have on the isobaric contours. We display extensive computerized calculations to illustrate all these points. Comparisons with experimental observations are shown to be quite favorable, particularly for the background-suppressed shell cross section, and for its acoustic spectrogram.
Use of High Throughput Genomic Tools for the Study of Endothelial Cell Biology (2003)

The endothelium is an active, dynamic and heterogeneous organ. It lines the vessels in every organ system and regulates diverse and important biological functions. Over the past several years researchers have gained enormous insights into endothelial cell function in physiological processes such as coagulation and vascular reactivity, and pathophysiological disease states such as inflammation and atherosclerosis. Despite our expanding knowledge of endothelial cell biology, the molecular mechanisms underlying these functions remain largely unknown. The newly developed high throughput genomic tools and accompanying analytical methods provide powerful approaches for identifying new endothelial cell genes and characterizing their role in health and disease. Here, we review some of the recent genomics and proteomic advances that are providing new methodologies for endothelial cell and vascular biology research.
CAPSULE ENDOSCOPY [CE] IN THE DETECTION AND MANAGEMENT OF NSAID INDUCED INJURY OF THE SMALL INTESTINE (2003)

s Submitted for the 68th Annual Scientific Meeting of the American College of Gastroenterology October 10-15, 2003, Baltimore, Maryland: SMALL INTESTINE/UNCLASSIFIED: PDF Only
Optimizing Channel Selection for the JPALS´ Land-based Integrity Monitor (2005)

JPALS (Joint Precision Approach and Landing System) is a precision landing system that provides LAAS (Local Area Augmentation System) like capabilities in a military operating environment. This paper discusses the landbased JPALS application and the enhancement of a selection algorithm called EXM (Executive Monitor). The EXM examines the pass/fail outputs of other monitors to define a common set of data based on exclusion of detected satellite or receiver faults. Prior versions of the EXM used heuristic rather than optimal criteria. Using data collected from Stanford´s LAAS IMT prototype, we evaluated the EXM algorithms with an analysis tool called the JTEP (JLIM Test Platform), where JLIM stands for the JPALS Land-based Integrity Monitor. The VPL (Vertical Protection Limit) is a high-integrity estimation of the landing aircraft’s vertical positioning error. It is a function of satellite geometry, the number of receivers, and the quality of each satellite’s ranging signal. When the VPL is below the VAL (Vertical Alarm Limit) the landing system is available. Our paper shows that an EXM decision method based on minimizing the VPL provides greater availability than previously achieved. The traditional method of defining a common set by maximizing the number of receivers is less complex to code and less computationally demanding than the VPL based method. However, our results show the VPL method provides better availability performance with sufficient computational efficiency to enable real-time operation. To establish the performance benefits of the VPL-based method, this paper presents two analyses. The first details a comparison of EXM decision logic for the all-in-view satellite case. The second shows the robustness of VPLbased algorithms to a degraded one-satellite out case. The degraded constellation reflects a user aircraft which is unable to track all the satellites, an even which may occur commonly in JPALS due to jamming, interference, or aerial maneuvers (obstruction).
<title>Relational template-matching algorithm for FLIR automatic target recognition</title> (1993)

Under the Army Night Vision & Electronic Sensors Directorate and the Army Research Laboratory (S<SUP>3</SUP>I) sponsored ATR Relational Template Matching (ARTM) program, we have developed a novel model-based forward-looking infrared (FLIR) automatic target recognition (ATR) algorithm with superior performance over other model-based and template matching algorithms. The ARTM algorithm represents a significant advance over other approaches because its performance is relatively insensitive to the extreme variations of target signatures in FLIR imagery. The algorithm has been extensively evaluated in Army-sponsored competitive tests on low-depression ground target scenarios. The ARTM algorithm correctly recognizes target signatures at less than one-half the signal-to-noise level required by other approaches. Also the algorithm performs consistently over signature variations with up to 30 percent shape error.
Mechanism design for multi-agent meeting scheduling including time preferences, availability, and value of presence (2004)

We examine the benefits and limitations of mechanism design as it applies to multi-agent meeting scheduling. We look at the problem of scheduling multiple meetings between various groups of agents that arise over time. Each of the agents has private information regarding their tune preferences for meetings. Our aim is to extract this information and assign the meetings to times in a way that maximises social welfare. We discuss problems with previous attempts to design incentive compatible (IC) and individually rational (IR) mechanisms for the task. We focus on the problem of determining when agents are available. In particular, we show that when agents with general valuation functions are asked to supply their availability for meeting times, there is no IC and IR mechanism. Given this impossibility result, we show how the likelihood of violating IR can be reduced through agents expressing their value for the presence of others at meetings. We also show how requesting agent preferences for entire schedules helps to eliminate IC problems.
Regulation of UDP-glucuronosyltransferase by lipid-protein interactions (1989)

The temperature dependence of two kinetic properties of the GT2P isoform of microsomal UDP-glucuronosyltransferase was studied for enzyme in intact microsomes and for pure enzyme reconstituted into different types of lipid bilayers. The properties studied were the non-Michaelis-Menten kinetics of the enzyme and activity at Vmax(app). For enzyme in intact microsomes, the pattern of non-Michaelis-Menten kinetics was seen at all temperatures in the range tested (23 to 48 degrees C), and the slopes of the Hill plots of the data were constant across this range of temperatures. Although non-Michaelis-Menten kinetics were present for pure enzyme in bilayers of 1,2-dimyristoylphosphatidylcholine or 1,2-dipalmitoylphosphatidylcholine only in the gel phase (Hockman, Y., Kelley, M., and Zakim, D. (1983) J. Biol. Chem. 258, 6509-6519), it was not possible to reconstitute this pattern of kinetics for enzyme at T greater than 40 degrees C. For example, GT2P displayed Michaelis-Menten kinetics in bilayers of 1,2-distearoylphosphatidylcholine at 44 degrees C. For enzyme in microsomes, activities at Vmax(app) increased with increasing temperature in the range 23 to 48 degrees C, with a discontinuity in the slope of the Arrhenius plot at 34 degrees C. This thermotropic property also could not be reconstituted with pure GT2P. Instead, activities at Vmax(app) for GT2P reconstituted in 1,2-dioleoylphosphatidylcholine, 1,2-distearoylphosphatidylcholine, or 1,2-stearoyl oleoylphosphatidylcholine increased in the range 23 to 37 degrees C, but then decreased at T greater than 37 degrees C. The fall in activity at T greater than 37 degrees C was reversible, indicating that GT2P undergoes a reversible change at 37 degrees C to a less active form of the enzyme. The differences between pure, reconstituted GT2P and microsomal GT2P indicate that the thermotropic properties of the microsomal enzyme are not properties of the enzyme per se but depend on interactions between it and other components in the microsome. The data suggest, therefore, that the properties of GT2P in microsomes results in part from an organization of components in the microsomal membrane.
Depressive symptoms, stress, and weight concerns among African American and European American low-income female smokers. (2002)

The relationships between perceived stress, depressive symptoms, concern about weight gain and smoking dependence were examined among 83 European American and 175 African American female smokers bringing children to pediatric clinics serving a low-income population. Among African American women, but not European American women, greater stress and more depressive symptoms predicted greater smoking dependence, and less concern about weight gain predicted greater smoking dependence. Multivariate analyses confirmed the bivariate relationships among stress, depressive symptoms, and smoking dependence among African American women but reduced the relationship between weight concern and smoking dependence. The stronger relationships among stress, depressive symptoms, and smoking dependence among African American women may be indicative of smoking patterns more associated with affect regulation than are the smoking patterns of European American women.
Additional file 1: Figure S1. of Impact of low high-density lipoprotein-cholesterol level on 2-year clinical outcomes after acute myocardial infarction in patients with diabetes mellitus (2016)

Receiver operating characteristic (ROC) curves of HDL-C for MACE and cardiac death. (DOCX 346Â kb)
Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor (2008)

Org 43553 is the first LMW LH-R mimetic with demonstrated in vivo efficacy upon oral administration and could therefore replace subcutaneously administered hCG. The elimination half-life of Org 43553 is substantially shorter than hCG, which could potentially represent a clinical benefit in reducing the risk of ovarian hyperstimulation syndrome (OHSS).
Construction of a rationally designed human cytomegalovirus variant encoding a temperature-sensitive immediate-early 2 protein (2002)

We generated a set of cysteine-to-glycine mutations and screened them to identify a temperature-sensitive allele of the human cytomegalovirus UL122 gene, which encodes the immediate-early 2 transcriptional activating protein. The mutant allele contains a single base pair substitution at amino acid 510. In transcription activation assays, the mutant protein activated the simian virus 40 early and human cytomegalovirus UL112 promoters at 32.5 degrees C but not at 39.5 degrees C. We constructed a mutant virus, BTNtsUL122, in which the wild-type UL122 locus is substituted with the mutant allele. The mutant produced progeny at 32.5 degrees C but not at 39.5 degrees C. Although the mutant virus accumulated immediate-early transcripts and proteins at the nonpermissive temperature, it did not produce any early (UL44 and UL54) and late (UL82) transcripts and it did not replicate its DNA. The mutant's defect at the nonpermissive temperature results, at least in part, from the inability of the temperature-sensitive immediate-early 2 protein to activate early viral promoters, whose products are required for DNA replication and progression into the late phase of the virus growth cycle.
The computation and bounding of rate-distortion functions (1969)

Methods are given for the numerical computation of Shannon's rate-distortion function <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R(D)</tex> for certain memoryless message sources. It is first assumed that <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">U</tex> , the set of possible message-source outputs, and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</tex> , the set of possible destination symbols, are countable. The computation of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R(D)</tex> for this case is reduced to a minimization problem in which the variables are the destination-symbol probabilities. For arbitrary <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">U</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</tex> , upper and lower bounds on <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R(D)</tex> are derived by partitioning <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">U</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</tex> each into a countable collection of disjoint subsets and employing the results derived previously for the case of countable <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">U</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</tex> . Conditions are then discussed under which these bounds can be made arbitrarily close to each other by choosing sufficiently fine partitions of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">U</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</tex> . Two examples are included to illustrate the results in detail.
Blind asynchronous near-far resistant FIR receivers for CDMA communication (2002)

A canonical structure of near-far resistant FIR receivers for asynchronous CDMA over ISI channels is proposed. The receiver structure includes a minimum-order FIR decorrelator and a bank of equalizers designed for each user. An equivalence between the decorrelator and the so-called statistical decorrelator is established, which leads to a blind near-far resistant FIR receivers based on decorrelating (second-order or higher-order) statistics.
Critical nature of the giant field-induced pyroelectric response in Pb(Mg1/3Nb2/3)O3–xPbTiO3 single crystals (2008)

We study the E-T phase diagram and dynamical pyroelectric coefficient of an (001)-oriented flux-grown 0.8Pb(Mg1/3Nb2/3)O3–0.2PbTiO3 single crystal. We found that the highest pyroelectric coefficient can be achieved at the point having quasicritical features. These data establish a quasicritical behavior of the field-induced pyroelectric coefficients in relaxors.
Large group formation in European Roe deer : an adaptive feature ? (1995)

The European roe deer (Capreolus capreolus) has locally colonized open agricultural lands for some decades. In the present paper, size of the winter groups of this species is compared at six sites of various openness, as well as in two of the sites for different population densities. Mean group size, reaching eight deer in the most open cultivated area, is found to increase with both habitat openness and population density. As the European roe deer probably evolved in mainly forest environments until recently, it is difficult to interpret its tendency to flock in large groups in agricultural plains as a feature set by natural selection. In this species, the increase of group size with habitat openness and population density could be the simple consequence of group instability. Large group formation might of course enhance the fitness of the deer now colonizing open agricultural lands, but it would in this case have to be considered as an «exaptation » (in the sense of Gould and Vrba) and not a genuine adaptation.
Rhodium-catalyzed Conjugate Addition of Arylstannanes to α,β-Unsaturated Ketones and Esters (1998)

Abstract Aryltrimethylstannanes react with α,β-unsaturated ketones and esters in the presence of a catalytic amount of a cationic rhodium complex, [Rh(cod)(MeCN)2]BF4, affording the conjugate addition products in good yields.
Production of Radionuclides in the Cooling Water for Electromagnetic Horns at the J-PARC Neutrino Experimental Facility (2015)

The cooling water for the electromagnetic horns is exposed to intense high-energy protons, neutrons and charged pions at the J-PARC neutrino experimental facility.These high-energy particles produce various radionuclides in the cooling water; dominant radionuclides were 3 H and 7 Be, and various -emitting nuclides were also detected by a Ge detector.Specific activities of individual nuclides in the circulating cooling-water were determined and compared with the results obtained by Monte Carlo calculations.The results demonstrated that 3 H and 7 Be were directly produced in water by nuclear spallation of oxygen in water molecules, and that other nuclides were produced in metal components and transferred into water, in accordance with the observations at other high-energy accelerator facilities.