gebhart/patrepeval huggingface dataset:
Congestion control for frame relay networks (1992)

The three main approaches to congestion control are compared, and an implicit congestion avoidance technique based on Kalman filtering is summarised. A four-stage cycle of throughput observation, congestion level prediction, traffic load adjustment decision and window modification is simulated for comparison, and performances are plotted against normalised background traffic intensity.
Viruses Cause Type 1 Diabetes in Animals (2006)

More than 10 viruses have been reported to be associated with the development of type 1 diabetes-like symptoms in animals, with the best evidence coming from studies on the D variant of encephalomyocarditis (EMC-D) virus in mice and Kilham rat virus (KRV) in rats. A high titer of EMC-D viral infection results in the development of diabetes within 3 days, primarily due to the rapid destruction of beta cells by viral replication within the cells. A low titer of EMC-D viral infection results in the recruitment of macrophages to the islets. Soluble mediators produced by activated macrophages play a critical role in the destruction of residual beta cells. A single amino acid at position 776 of the EMC viral genome controls the diabetogenicity of the virus. In contrast, KRV causes autoimmune type 1 diabetes in diabetes-resistant BioBreeding (DR-BB) rats without direct infection of beta cells. Macrophages play an important role in the development of diabetes in KRV-infected DR-BB rats. As well, KRV infection preferentially activates effector T cells, such as Th1-like CD45RC(+)CD4(+) T cells and CD8(+) T cells, and downregulates regulatory T cells, such as Th2-like CD45RC(-)CD4(+) T cells. This results in the breakdown of the immune balance, contributing to the development of diabetes in KRV-infected DR-BB rats.
A Novel Design of Rotor Contour for Variable Reluctance Resolver by Injecting Auxiliary Air-Gap Permeance Harmonics (2015)

This paper proposes a novel rotor contour design for variable reluctance (VR) resolvers by injecting auxiliary air-gap permeance harmonics. Based on the resolver model with nonoverlapping tooth-coil windings, the influence of air-gap length function is first investigated by finite element (FE) method, and the detection accuracy of designs with higher values of fundamental wave factor may deteriorate due to the increasing third order of output voltage harmonics. Further, the origins of the third harmonics are investigated by analytical derivation and FE analyses of output voltages. Furthermore, it is proved that the voltage harmonics and the detection accuracy are significantly improved by injecting auxiliary air-gap permeance harmonics in the design of rotor contour. In addition, the proposed design can also be employed to eliminate voltage tooth harmonics in a conventional VR resolver topology. Finally, VR resolver prototypes with the conventional and the proposed rotors are fabricated and tested respectively to verify the analyses.
Self-Aligned Process for Selectively Etched p-GaN-Gated AlGaN/GaN-on-Si HFETs (2018)

A process for an enhancement-mode p-GaN-gated heterostructure field-effect transistor with self-aligned structuring of the p-GaN is proposed. A gate-first process is employed, for which the gate metallization acts as contact and etch mask simultaneously. In the access region, the p-GaN is selectively removed in a dry-etch process by a Cl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gas mixture. Due to self-aligned processing and precise etch depth control, devices achieve a high saturation current of 554 mA · mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , a threshold voltage of 1.08 V, breakdown voltages up to 560 V, and dynamic <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> increase of 45% for 200-V stress bias.
Gadolinium-153 production at the Oak Ridge National Laboratory (1988)

Gadolinium-153 production at ORNL involves the neutron irradiation of natural europium oxide (47.8% /sup 151/Eu, 52.2% /sup 153/Eu). This target material undergoes a series of neutron captures and radioactive decays to produce the desired /sup 153/Gd product. Several undesirable europium isotopes (/sup 152/Eu, /sup 154/Eu, and /sup 156/Eu) are also produced during this irradiation process. Recent technical advances and other improvements in the radiochemical processing of this isotope have allowed ORNL to increase production by more than sevenfold. A newly developed electrochemical process separates the bulk of undesirable europium isotopes. The use of this process increases the efficiency of the high-pressure ion exchange step and effects a final product purity of >99.999%. Specific activities >60 Ci/g of gadolinium oxide and product specific yields >2.9 Ci/g of irradiated europium oxide have been produced. Use of unique glove box manipulators and special equipment designed at ORNL have allowed final source fabrication to keep pace with the increased production rate while minimizing the radiation exposure to operating personnel. 3 figs., 4 tabs.
Making sense in primary care: levelling the playing field for people with communication difficulties (2005)

Primary care depends on the effective communication between service user and practitioner. This study proposes that people with communication difficulties serve as a litmus test for whether practitioners are truly sensitised to the impact of their own communication skills. It is based on interviews with service users and carers. Three key themes emerged, namely inclusion, the process of communication, and continuity. Inclusion is concerned with effective participation in society in general and access to health care in particular. The communication process describes the way in which health issues are raised and addressed. Continuity refers to the way in which time interacts with the relationship between user and provider. The paper concludes that effective communication is not simply a set of taught behaviours but reflects a set of values that create the conditions for improving both communication and clinical outcomes.
Quasielastic Electron-Deuteron Scattering in a Hybrid Quark-Hadron Model (1999)

We study the effects of six-quark cluster and meson exchange current on quasielastic electron-deuteron scattering, using the hybrid quark-hadron model incorporating the contribution of the isoscalar meson exchange current. Our results indicate that the final state interaction, isoscalar and isovector meson exchange currents, and six-quark cluster contribute few to the quasielastic peak. However, they affect the extracted neutron electromagnetic form factors to some extent.
Preparation, cellular uptake and angiogenic suppression of shikonin-containing liposomes <i>in vitro</i> and <i>in vivo</i> (2012)

Shikonin has anticancer activity, but it has not yet been applied into clinical use. In the present study, shikonin was prepared using liposomes. We aimed to examine several aspects of sh-L (shikonin-containing liposomes): preparation, angiogenic suppression and cellular uptake through self-fluorescence. Sh-L were prepared using soybean phospholipid and cholesterol to form the membrane and shikonin was encapsulated into the phospholipid membrane. Three liposomes were prepared with shikonin. They had red fluorescence and were analysed using a flow cytometer. Angiogenic suppression of sh-L was determined using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide], Transwell tests, chick CAM (chorioallantoic membrane) and Matrigel™ plug assay. MTT assay showed the median IC₅₀ (inhibitory concentrations) as follows: shikonin, sh-L₁ and sh-L₂ were 4.99±0.23, 5.81±0.57 and 7.17±0.69 μM, respectively. The inhibition rates of migration were 53.58±7.05, 46.56±4.36 and 41.19±3.59% for 3.15 μM shikonin, sh-L₁ and sh-L₂, respectively. The results of CAM and Matrigel plug assay demonstrated that shikonin and sh-L can decrease neovascularization. Effect of shikonin was more obvious than sh-L at the same concentration. The results showed that sh-L decreased the toxicity, the rate of inhibition of migration and angiogenic suppression. The cellular uptake of the sh-L could be pictured because of the self-fluorescence. The self-fluorescence will be useful for conducting further research. Sh-L might be an excellent preparation for future clinical application to cancer patients.
Using Virtual Reality Aided Design Techniques for Three-dimensional Architectural Sketching (1996)

With this paper we would like to introduce a system which supports the early phases of the architectural design process. The system consists of two main components: the software solution "voxDesign" and the physical environment "platform". Our aims are: to formulate, develop, and evaluate an architectural design system through the use of VR (virtual reality) space. The exploration and development of design intentions is supplemented by a new method of three dimensional sketching. In the second part of this paper we will show how these components were used to train students in architecture and design at our university. Parts of this paper were published to the academic public at "Designing Digital Space". (Regenbrecht 1996)
Sectorized channel borrowing scheme with resource pooling (2003)

Since channels in a radiocommunications system are a scarce resource, efficient assignment and reuse techniques are required to improve the overall efficiency. Channel borrowing has been proposed to allow relief of hot spot or temporary high traffic cell overload. In this paper we show an improvement in the channel borrowing scheme that improves the system performance by sharing part of the channels among different sectors of a cell. This pooling of the available resources lowers the call blocking probability compared with traditional borrowing schemes mainly at low and moderate loads of about 10% and also at system saturation. It is also shown that for given cluster shapes, it is not required that a channel is blocked or its power reduced in isofrequential cells. Results obtained by means of discrete simulations are presented to support these statements.
Vanillin-Derived High-Performance Flame Retardant Epoxy Resins: Facile Synthesis and Properties (2017)

Lignin derivative vanillin when coupled with diamines and diethyl phosphite followed by reaction with echichlorohydrin yields high-performance flame retardant epoxy resins. Biorenewable and environment-friendly flame retardant alternatives to bisphenol A epoxy resins (having plenty of applications such as coatings, adhesives, composites, etc.) have captured great attention due to their ecological and economic necessity. Vanillin, an industrial scale monoaromatic compound from lignin, is a promising sustainable candidate for high-performance polymers, while synthesis of diepoxies is challenging. Meanwhile, bio-based epoxy resins combining high performance and excellent fire resistance are more difficult to be achieved. In this paper, two novel bio-based epoxy monomers EP1 and EP2 were synthesized by one-pot reaction containing Schiff base formation and phosphorus–hydrogen addition between vanillin, diamines, and diethyl phosphite, followed by reacting with epichlorohydrin. Their reactivities are similar to bisphenol A epoxy resin DGEBA. After curing they showed excellent flame retardancy with UL-94 V0 rating and high LOI of ∼32.8%, which was due to the outstanding intumescent and dense char formation ability. Meanwhile, it was found that the cured vanillin-based epoxies had exceedingly high Tgs of ∼214 °C, tensile strength of ∼80.3 MPa, and tensile modulus of ∼2709 MPa, much higher than the cured DGEBA with Tg of 166 °C, tensile strength of 76.4 MPa, and tensile modulus of 1893 MPa; the properties of vanillin-based epoxies are easy to be regulated by using different “coupling” agents—diamines—during the synthesis process.
Properties of Nonwood Fibers (1998)

Nonwood or agro-based fibers are a potential source of pulping material. However, these fibers have tremendous variations in chemical and physical properties as compared to wood fiber. This study presents some chemical and physical properties of nonwood fibers derived from selected tissues of various monocotyledonous and dicotyledonous plants. Properties were compared for different fiber lengths at different growth stages and plant stalk heights.
Gene expression of Na+/Ca2+ exchanger during development in human heart (2000)

The data demonstrate changes in NCX transcript and NCX protein levels as well as total RNA and proteins during human heart development. Per wet weight, NCX mRNA was 4.5 times greater at early fetal than adult stages and NCX protein was 2 times greater at adult than the early fetal stage indicating considerable post-transcriptional regulation. These findings provide new insights into the understanding of temporal changes in NCX in the developing heart at the gene level. The functional significance remains to be determined.
Secure Message Distribution Scheme with Configurable Privacy for Heterogeneous Wireless Sensor Networks (2008)

Security and privacy of wireless sensor networks are key research issues recently. Most existing researches regarding wireless sensor network security consider homogenous sensor networks. To achieve better security and performance, we adopt a heterogeneous wireless sensor network (HWSN) model that consists of physically different types of sensor nodes. This paper presents a secure message distribution scheme with configurable privacy for HWSNs, which takes advantage of powerful high-end sensor nodes. The scheme establishes a message distribution topology in an efficient and secure manner. The sensor node can only generate one signature for all the messages for all the users, which can greatly save the communication and computation costs of the sensor node. On the other hand, the user can only know the messages intended for him based on a pre-set policy, which can meet the requirement of the privacy. We show that the scheme has small bandwidth requirements and it is resilient against the node compromise attack.
Language, Culture, and Identity in Online Fanfiction (2006)

This article draws on constructs in second-language acquisition, literacy, cultural, and media studies as theoretical bases for examining how networked technologies and fan culture provide a young English language learner (ELL) with a site for developing her English language and writing skills. During this process, she also develops an online identity as a popular, multiliterate writer. To understand how this happens, the notion of identity is explored as a fluid construct that shifts over time with this ELL's long-term participation in a fan community. Popular and fan culture are also examined as points of affiliation and as dialogic resources that she appropriates, both in her writing and in her interactions with other fans. In so doing, the article demonstrates how popular culture and technology converge to provide a context in which this adolescent ELL is able to develop a powerful, transcultural identity, discursively constructed through the different cultural perspectives and literacies that she and other fans from across the globe bring to this space.
Electroporation as an Efficient Physical Enhancer for Skin Drug Delivery (2009)

Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of high-voltage pulses to the skin increases its permeability (electroporation) and enables the delivery of various substances into and through the skin. The application of electroporation to the skin has been shown to increase transdermal drug delivery. Moreover, electroporation, used alone or in combination with other enhancement methods, expands the range of drugs (small to macromolecules, lipophilic or hydrophilic, charged or neutral molecules) that can be delivered transdermally. The efficacy of transport depends on the electrical parameters and the physicochemical properties of drugs. The in vivo application of high-voltage pulses is well tolerated, but muscle contractions are usually induced. The electrode and patch design is an important issue to reduce the discomfort of the electrical treatment in humans. This review presents the main findings in the field of electroporation-namely, transdermal drug delivery. Particular attention is paid to proposed enhancement mechanisms and trends in the field of topical and transdermal delivery.
Derivation and Validation of New Simulation-Based Surrogate Safety Measure (2008)

Traffic safety evaluation is one of the most important processes in analyzing transportation systems performance. Traditional methods like statistical models and before-after comparisons have many drawbacks, such as limited time periods, sample size problems, and reporting errors. The advancement of traffic conflict techniques combined with microsimulation offers a potentially innovative way for conducting safety assessment of traffic systems even before safety improvements are implemented. In this paper, simulation-based safety studies are reviewed, and a modified simulation-based surrogate safety measure and a new simulation-based surrogate safety measure that can capture the probability of collisions, as well as the severity of these potential collisions, are proposed. Conceptual and computational logic of the proposed surrogate safety indicators are described in detail. These surrogate safety indices are initially proposed for link-based analysis and should not be used for other purposes, such as intersection safety assessment, without further enhancements, and the use of these indices should be limited to the analysis of linear conflicts. In addition, these link-based indices are extended to be able to conduct aggregate networkwide safety assessments. The proposed indices are validated by means of a well-calibrated traffic simulation model of a section of the New Jersey Turnpike and real accident data from the same section. Preliminary results indicate a strong relationship between the proposed surrogate safety measures and real accident data. Further research is needed to investigate these new surrogate safety indices under different locations and traffic conditions.
Kinetic Modeling of the Autohydrolysis of Lignocellulosic Biomass for the Production of Hemicellulose-Derived Oligosaccharides (2004)

Xylose-based oligosaccharides produced from xylan-rich hemicelluloses (xylo-oligomers) are carbohydrates with potential food and pharmaceutical uses. Autohydrolysis of lignocellulosic biomass is an efficient way to produce xylo-oligomers in a reasonable yield and a wide variety of compositions (anhydroarabinose/anhydroxylose and acetyl/anhydroxylose mass ratios). In this work, we develop a kinetic model for the autohydrolysis of xylan in lignocellulosic biomass that describes the yields of the different reaction products and explains the changes in the chemical composition of the xylo-oligomers due to reaction temperature and time. This model assumes that xylan is made up of three monomers (xylose, arabinose, and acetic acid) and that there are two xylan fractions with different compositions and reactivities toward hydrolysis. Both fractions are hydrolyzed to xylo-oligomers, which are hydrolyzed to xylose, arabinose, and acetic acid. Finally, monosaccharides dehydrate to furfural and degradation products. The model is validated with experimental data obtained for the autohydrolysis of corncobs in a batch reactor system at temperatures from 150 to 190 °C. The amount and composition of each xylan fraction, as well as the activation energies and frequency factors for all the reactions, are calculated from the experimental data. This model provides a satisfactory interpretation of the experimental data.
Evaluation of the Biochemical Targets of Genistein in Tumor Cells (1995)

Although data from epidemiological studies and cancer models suggest that genistein plays an important role in cancer prevention, the biochemical target(s) of genistein action is (are) not known. Genistein is a potent in vitro inhibitor of protein tyrosine kinase (PTK) activity, especially that of the epidermal growth factor receptor (EGF-R), having little effect on serine/threonine kinases. This led to the suggestion that genistein might exert its anti-cancer effects through inhibiting the activity of EGF-R PTK, or other crucial PTK's in vivo. Subsequent studies on intact tumor cell lines demonstrated that EGF-R and other growth factor receptors are able to transmit mitogenic signals in the presence of genistein. In fact, it is difficult to detect decreases in the tyrosine phosphorylation of discrete proteins after genistein treatment. Other mechanisms for the effect of genistein have been suggested from in vitro and cell culture data. Genistein not only inhibits the activity of purified topoisomerase II in vitro, but also leads to the accumulation of protein-associated single strand breaks in whole cells. Genistein also inhibits the production of reactive oxygen species which may lead to tissue damage and DNA modification. Additionally, genistein acts as a weak estrogen, modifies cellular differentiation programs, inhibits angiogenesis. modulates cell cycle events and may precipitate apoptosis. However, few of the above mechanisms in tumor cells are sensitive to the physiological serum concentrations of genistein (< 18.5 mumol/L, or < 5 micrograms/mL). Primary, nontransformed human mammary epithelial cells, which have a much greater sensitivity to genistein, would be a better system for the study of these mechanisms.
Antitumor active drugs as intercalators of deoxyribonucleic acid: Molecular models of intercalation complexes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntitumor active drugs as intercalators of deoxyribonucleic acid: Molecular models of intercalation complexesUlf Pindur , Manfred Haber , and Kristin Sattler Cite this: J. Chem. Educ. 1993, 70, 4, 263Publication Date (Print):April 1, 1993Publication History Received3 August 2009Published online1 April 1993Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ed070p263https://doi.org/10.1021/ed070p263research-articleACS PublicationsRequest reuse permissionsArticle Views511Altmetric-Citations120LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts