gebhart/patrepeval huggingface dataset:
Metal Dependency for Transcription Factor Rho Activation (2003)

The Escherichia coli rho transcription termination factor terminates select transcripts and rho activity requires Mg(2+). We investigated whether divalent metal ions other than Mg(2+) catalyze rho-dependent ATP hydrolysis to ADP and P(i) in vitro. The effects of 11 divalent metal ions (Be(2+), Ca(2+), Cd(2+), Co(2+), Cu(2+), Hg(2+), Mn(2+), Ni(2+), Sr(2+), VO(2+), Zn(2+)) on ATPase activity were determined in the absence and presence of MgCl(2). Without MgCl(2), Ca(2+), Cd(2+), Co(2+), Cu(2+), Hg(2+), Mn(2+), Ni(2+), VO(2+), and Zn(2+) activated ATP hydrolysis with either hyberbolic (Ca(2+), Co(2+), Cu(2+), Hg(2+), VO(2+)), peak velocity (Cd(2+), Mn(2+), Zn(2+)), or sigmoidal (Ni(2+)) rate acceleration curves. Sr(2+) was found to be a nonactivator and Be(2+) an inhibitor of rho-dependent ATPase activity. The metals' effects were compared with Mg(2+) and gave different rank orders when either the velocity (V(max), V(peak)) or the efficiency (V(max)/K(M), V(peak)/K(M)) of ATP hydrolysis was used as the determinant (V: Mg(2+) approximately Mn(2+) > Zn(2+) > Co(2+) > Ni(2+) approximately Cd(2+) > Ca(2+) > Cu(2+) > Hg(2+) approximately VO(2+); V/K(M): Mg(2+) > Mn(2+) > Ca(2+) > Co(2+) > Zn(2+) > Cu(2+) > Ni(2+) > Hg(2+) > Cd(2+)). Mg(2+) proved to be the most effective divalent metal. We observed that the metal-dependent rates were affected by metal ion interactions with rho, RNA, and the buffer constituents. Significantly, replacement of the octahedral Mg(2+) ion by metals that typically prefer coordination spheres less than six (Cd(2+), Co(2+), Ni(2+), VO(2+), Zn(2+)) led to ATPase activity, suggesting that the putative Mg x ATP(2-) coordination sphere in rho does not need to remain fully intact for ATP hydrolysis.
Elicitation of<i>Rx</i>-Mediated Resistance to PVX in Potato Does Not Require New RNA Synthesis and May Involve a Latent Hypersensitive Response (1998)

The Rx gene in potato confers extreme resistance against potato virus X (PVX) that is elicited by the viral coat protein (CP). Using actinomycin D to inhibit transcription of nuclear genes, we have shown that Rx is expressed prior to virus inoculation and that induction of the resistance mechanism does not require novel gene expression or continued transcription of previously expressed genes. We have also shown that transgenic plants could not be produced carrying a CP transgene from an Rx-avirulent PVX in an Rx background. These data indicate that Rx-mediated resistance involves a mechanism that suppresses viability of plant cells.
Heat and Mass Transfer in Open-Cycle OTEC Systems (1984)

The temperature difference between surface and deep water in the oceans represents a vast resource of thermal energy. A promising method of harnessing this resource is the open-cycle ocean thermal energy conversion (OC-OTEC) system, which utilizes steam evaporated from the surface water to power the turbine. In this paper the state of the art of heat and mass transfer related to evaporation and condensation of steam at low pressures in OC-OTEC is summarized and relevant research issues are discussed.
[Clinical study of nanometer calcium phosphate ceramic artificial bone]. (2009)

The artificial bone has no immunogenicity, no rejection,does not affect the blood calcium and phosphorus content, and has higher osteogenic activity. It is affirmed that nanometer ceramics artificial bone is used to treat the smaller bone defect on clinical.
A Varactor-Based Very Compact Tunable Filter with Wide Tuning Range for 4G and Sub-6 GHz 5G Communications (2020)

A very compact microstrip reconfigurable filter for fourth-generation (4G) and sub-6 GHz fifth-generation (5G) systems using a new hybrid co-simulation method is presented in this manuscript. The basic microstrip design uses three coupled line resonators with λ/4 open-circuited stubs. The coupling coefficients between the adjacent and non-adjacent resonators are used to tune the filter at the required center frequency to cover the frequency range from 2.5 to 3.8 GHz. The coupling coefficient factors between the adjacent resonators are adjusted to control and achieve the required bandwidth, while the input and output external quality factors are adjusted to ensure maximum power transfer between the input and output ports. Two varactor diodes and biasing circuit components are selected and designed to meet the targeted performance for the tunable filter. The impedance bandwidth is maintained between 95 and 115 MHz with measured return losses of more than 17 dB and measured insertion loss of less than 1 dB. Computer simulation technology (CST) is utilized to design and optimize the presented reconfigurable filter, with hybrid co-simulation technique, using both CST microwave studio (MWS) and CST design studio (DS), is applied to build the model by considering the SPICE representation for the varactor switches and all electronic elements of the biasing circuit. The introduced reconfigurable microstrip filter is also fabricated using a Rogers RO3010 material with a relative dielectric constant of 10.1 and it is printed on a very compact size of 13 × 8 × 0.81 mm<sup>3</sup>. An excellent agreement is obtained between the simulation and measurement performance.
A reduced rank MMSE receiver for a DS-CDMA system in frequency selective multipath (2002)

A new reduced rank adaptive algorithm, for asynchronous DS-CDMA interference suppression in the presence of frequency selective multipath interference is presented. The algorithm employs a computationally efficient, correlation-subtraction architecture based on the multistage Wiener filter. It is shown that with enough sample support, this reduced rank technique performs as well as the full rank MMSE solution without requiring matrix inversion, eigendecomposition, or the construction of blocking matrices. At low sample support, the MWF performance is shown to exceed that of MMSE with the additional bonus of reduced complexity. System performance is characterized for a highly loaded asynchronous DS-CDMA system in the presence of multipath interference and the performance of the multistage Wiener filter is compared to the MMSE and RAKE receivers.
Diffusion-based distributed adaptive estimation utilizing gradient-descent total least-squares (2013)

We develop a gradient-descent distributed adaptive estimation strategy that compensates for error in both input and output data. To this end, we utilize the concepts of total least-squares estimation and gradient-descent optimization in conjunction with a recently-proposed framework for diffusion adaptation over networks. The proposed strategy does not require any prior knowledge about the noise variances and has a computational complexity comparable to the diffusion least mean square (DLMS) strategy. Simulation results demonstrate that the proposed strategy provides significantly improved estimation performance compared with the DLMS and bias-compensated DLMS (BC-DLMS) strategies when both the input and output signals are noisy.
Men’s Work-Related Stress and Mental Health: Illustrating the Workings of Masculine Role Norms (2019)

Although a strong relationship between employment and men's mental health has been identified, theoretical linkages between masculinity, employment, and mental health are not well developed and mental health supports that account for gender and employment are correspondingly inadequate. The purpose of this study is to contribute to theoretical understandings of men's employment-related mental health experience and raise possibilities for gender-responsive employer supports for men's mental health. Specifically, this study is a secondary analysis of narrative accounts from 18 men employed in male-dominated occupations about their employment-related mental health. Results of this study present evidence of processes by which theoretical concepts of masculine role norms influence work-related stress and mental health including: (a) injunctive norms, which operate through an internal sense of the cultural "shoulds" and "should nots"; (b) descriptive norms, which are communicated through the behaviors that a man sees other men enacting in his immediate environment; and (c) cohesive norms, which exert influence through observations of how men who are leaders, behave. Men's insights into the complexity of employment-related stress and mental health according to masculine role norms related to work demands and leadership modeling and messaging are discussed. This study concludes with potential ways forward for employer support for men's mental health.
ChemInform Abstract: SYNTHESIS OF 5‐AMINO‐2‐PYRROLIDINONE AND ITS DERIVATIVES (1981)

Abstract Aus der Lactamcarbonsäure (Ia) erhält man über eine Abbaureaktion das Carbamat (IV).
Crystallographic analyses of enzymes involved in lysine biosynthetic pathway of Thermus thermophilus (2008)

Introduction Lysine is the essential amino acid for animals. Plants biosynthesize lysine via DAP pathway, while fungi or yeast biosynthesize lysine from AAA. On the other hand, we found that Thermus thermophilus synthesizes lysine via AAA pathway, although it is a bacterium. The enzymes involved in the former half of this pathway have similarity to those involved in leucine biosynthetic pathway or TCA cycle. The enzymes involved in latter half contain enzymes similar to those involved in arginine biosynthetic pathway. To investigate the mechanism of catalytic mechanism and substrate recognition in the enzymes of this unique lysine biosynthetic pathway, we preceed the crystallographic analyses of the enzymes involved in this pathway.
A robust sliding mode observer for speed estimation of induction machine (2002)

In this paper, a new sliding mode flux and speed observer is proposed. The flux observer accuracy is guaranteed through the current observer. The error between the actual current and observed current converges to zero which guarantees the accuracy of the flux observer. The rotor speed is estimated by the observer based on the measured and estimated stator currents and estimated rotor flux. In addition, the command voltages are used rather then the measured ones. Therefore, in the proposed algorithm, only current sensors are needed. The new approach is verified by simulation and experimental results. The experimental results show the robustness and performance of the proposed observer structure.
Transplantation biology : cellular and molecular aspects (1996)

This text aims to provide a complete understanding of the complex biological events involved in organ transplantation, allograft rejection and immunosuppression. The first section presents background information on cellular and molecular physiology and describes the techniques used in contemporary transplantation biology. The book then examines the antigen-independent and antigen-dependent host defence mechanisms evoked during organ transplantation, particularly the permutations of lymphocyte physiology. Also included are discussions of T- and B-cell tolerance and the immunosuppressive functions of the liver. The next section focuses on the manifestations of solid organ rejection. The final section examines immunosuppression and explores future methods for manipulating host responses to allografts and xenografts.
A Case of Gastric CD56+ Extranodal NK/T-cell Lymphoma, Nasal Type (2006)

A NK/T cell lymphoma is highly aggressive lymphoma of a putative NK-cell origin with a predominant extranodal presentation and a rapidly fatal course. CD56 has been reported to be the most reliable marker for a NK/T cell lymphoma. A NK/T cell lymphoma is strongly associated with the Epstein-Barr virus. We report a case of an aggressive NK/T cell lymphoma presenting as a gastric ulcer. A 52-year-old female patient presented with hematochezia and fever. The endoscopic finding showed a gastric ulcer with a recent bleeding stigma. Histologically, the gastric biopsy showed a diffuse infiltration of small or medium sized lymphoma cells with an angiocentric growth pattern and necrosis. The lymphoma cells were CD56+, CD3+, CD20-, which are consistent with a NK/T cell lymphoma. Unfortunately, the patient was discharged without treatment. We report this case with a review of the relevant literature.
Synthesis and Polymerization of 6-Hydroxy-4-hydroxymethylhexanal Diethyl Acetal and 5-Hydroxy-4-hydroxymethylpentanal Diethyl Acetal<sup>1</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Polymerization of 6-Hydroxy-4-hydroxymethylhexanal Diethyl Acetal and 5-Hydroxy-4-hydroxymethylpentanal Diethyl Acetal1C. S. Marvel and John J. DrysdaleCite this: J. Am. Chem. Soc. 1953, 75, 18, 4601–4602Publication Date (Print):September 1, 1953Publication History Published online1 May 2002Published inissue 1 September 1953https://pubs.acs.org/doi/10.1021/ja01114a522https://doi.org/10.1021/ja01114a522research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The synthesis of tritiated 2-phenyl-4-[4-(2-pyrimidyl)piperazinyl]methylimidazole ([3H] NGD 94-1), a ligand selective for the dopamine D4 receptor subtype (1997)

A tritiated ligand for the dopamine D4 receptor subtype, 2-phenyl-4-[4-(2-pyrimidyl) piperazinyl] methylimidazole ([3H] NGD 94-1), was prepared in six steps starting with 3, 5-dichlorobenzonitrile. NGD 94-1 was shown to have a greater than 500 fold specificity for D4 over other dopamine receptor subtypes. © 1997 John Wiley & Sons, Ltd.
Quality Enhancement of Sexually Mature Chum Salmon Oncorhynchus keta in Retort Pouches (1991)

ABSTRACT Sexually mature or late‐run chum salmon muscle was packaged in thin‐profile retort pouches and in conventional 307 × 200 metal cans. After retort processing to equivalent lethality, samples were evaluated by sensory and instrumental methods. The pouch product was firmer, more fibrous, drier and chewier than the canned. Less late‐run flavor and greater overall acceptability were reported for pouch‐processed samples. More free liquid was found in pouches than in cans. Histological examination revealed a more compact structure in chum muscle processed in retort pouches, possibly due to air over‐pressure applied to flexible pouches during processing.
Progress on the road to new nerve agent treatments (2001)

In the 50 years since nerve agents were developed a great deal has been learned about their acute toxicity, treatment and prophylactic strategies. However, the currently fielded treatments are not significantly different from those available at the end of World War II. Reasons for this lack of progress and strategies to circumvent those intrinsic problems that have impeded progress are discussed, with emphasis on the development of scavengers to be introduced as prophylactics that will significantly reduce the effective dose and thus protect against multiple times the normal LD50.
Functional Variation Among Parrotfishes: are they Complementary or Redundant? (2018)

Herbivory is a critical process that underpins coral reef structure and function. Parrotfishes play significant roles in the herbivore guild by removing macroalgae, promoting coral settlement and growth, producing sediment by bioeroding carbonate substrates, and preying on corals. This chapter addresses patterns in functional variation among parrotfishes and how species of parrotfishes are either complementary or redundant to other members of the herbivore guild. Herbivore and parrotfish diversity is critical for maintaining ecosystem function because herbivores differ in sensitivity to algal chemical, morphological, and structural defenses. In addition to complex patterns in complementarity in diet selection, parrotfish species are diverse in their spatial foraging patterns, life history strategies, habitat use, and responses to predators. This functional variation and complementarity within parrotfishes and among other herbivorous species results in important positive impacts of herbivore diversity on coral reefs. Increasing parrotfish and herbivorous fish diversity often results in increased macroalgal consumption and increased success of corals. Thus, the complementary roles that parrotfishes play are important for the ecosystem function of coral reefs.
Risk and Countermeasures of Human Resources Outsourcing (2009)

When division of labor in social specialization is increasing,human resources outsourcing has emerged,and becomes a new managing model.Human Resources Outsourcing(HRO) brings competitive advantage to companies as well as risk.This paper uses SWOT analysis to analyze its strength,weakness,opportunity and threat,discusses the risk in HRO,and suggests some countermeasures.
Biosynthesis of osteonectin by fetal porcine calvarial cells in vitro. (1984)

The biosynthesis of osteonectin, a major glycoprotein of bone, has been studied in vitro using bone cells from fetal porcine calvariae. The calvarial cells, which were shown to produce osteonectin by immunotransfer and immunocytochemical analysis, were pulse labeled with [35S]methionine and the radiolabeled osteonectin in the cell layers and in the chase-medium was isolated by specific immunoprecipitation. The osteonectin, representing 0.1% of the radiolabeled cell layer and 1% of the medium proteins, co-migrated with authentic bovine osteonectin on sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reduced and nonreduced conditions (Mr approximately 40,000), and was bound selectively to hydroxyapatite in the presence of 4 M guanidine HCl. The co-migration of the osteonectins indicates that the tissue-extracted osteonectin represents an intact protein and that a pro- form of osteonectin is unlikely. However, a preosteonectin form (Mr approximately 46,000) could be immunoprecipitated from cell-free translation of calvarial mRNA. The minimal secretion time for osteonectin synthesized in serum-containing medium was found to be approximately 40 min but maximal accumulation did not occur until 2 h postlabeling. In serum-free media, extensive degradation of osteonectin, characterized by the presence of two immunoprecipitable fragments (Mr approximately 36,000 and 31,000), was evident.
High-efficiency switching power supply unit with synchronous rectifier (2002)

This report describes an insulation-type switching power supply unit (DC/DC power converter) for mainframe computers that uses a newly developed synchronous rectifying circuit for the secondary rectification component. Compared with conventional switching power supply units, this unit offers 6% higher processing efficiency, and power output per unit volume that has been boosted by 1.75 times. As a result, this unit provides high efficiency, low voltage and high power output.
A gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity (1992)

A highly malignant human T-cell leukemia was identified by cell surface analysis as a member of the T-cell receptor (TCR) gamma delta lineage. Cytogenetic and molecular analysis showed a novel t(8;14)(q24;q11) rearrangement involving the J delta 1 gene segment on chromosome 14 and the distal end of chromosome 8 near the c-myc proto-oncogene locus. The gamma delta TCR of the leukemia blasts was functionally intact and could be activated to generate intracellular calcium flux and to target Fc receptor-mediated redirected tumor cell lysis. In addition, non-major histocompatibility complex restricted lysis of a limited target cell panel was shown by fresh leukemic blasts and by the in vitro-maintained leukemia cells that was comparable to known T-cell lines with natural killer-like activity. These data suggest that the T-cell leukemia potentially had in vivo functional cytolytic activity. However, whether this activity did contribute to the patient's clinical condition could not be determined.
Prognostic value of extranodal extension and other lymph node parameters in patients with upper tract urothelial carcinoma. (2012)

281 Background: The aim of the current study was to assess the prognostic value of extranodal extension (ENE) and other lymph node (LN) parameters in a large multicenter cohort of patients with LN metastasis (LNM) following radical nephroureterectomy (RNU). Methods: Retrospective analysis of 222 patients with LNM treated with RNU for upper tract urothelial carcinoma (UTUC) without neoadjuvant therapy. Microscopically, each LN metastasis was evaluated for presence of ENE. Results: The median number of LNs removed, number of positive LNs, and LN density were 4 (IQR: 8), 2 (IQR: 2), and 51.3% (IQR: 71.7%), respectively. Overall, 110 patients (49.5%) had ENE. Presence of ENE was associated with more advanced pT stage (p=0.026). In multivariable analyses, ENE was associated with disease recurrence (p=0.01) and cancer-specific mortality (p=0.013). LN density, when stratified by 30% cutoff, was associated with disease recurrence and cancer-specific mortality (p=0.048 and p=0.049) in univariable, but not in multivariable analyses. Addition of ENE to a multivariable model including pT stage and tumor architecture improved predictive accuracy for disease recurrence from 70.3% to 74.5% (p<0.001). Addition of ENE to a multivariable model including age, pT stage, and tumor architecture improved predictive accuracy for cancer-specific mortality from 70.6% to 74.4% (p<0.001). Conclusions: ENE is a powerful predictor of clinical outcomes in UTUC patients with LNM. While other LN parameters seem to have limited clinical value, ENE could help risk stratify UTUC patients with LNM for better counseling and clinical trial design.
Using CAD tools for shortening the design cycle of high-performance sigma–delta modulators: A 16·4 bit, 9·6 kHz, 1·71 mW ΣΔM in CMOS 0·7 μm technology (1997)

This paper uses a CAD methodology proposed by the authors to design a low-power second-order ΣΔM. This modulator has been fabricated in a 0·7 μm CMOS technology to be used as the front-end of an energy-metering mixed-signal ASIC and features 16·4 bit at a digital output rate of 9·6 kHz with a power consumption of 1·71 mW. It yields a value of the power(W)/(2Resolution(bit)×output rate (Hz)) figure which is the smallest reported to now, thus demonstrating the possibility to design high-performance embeddable ΣΔMs using CAD methodologies. © 1997 by John Wiley & Sons, Ltd.