gebhart/patrepeval huggingface dataset:
Recurrent Mutations of <i>MYD88</i> and <i>TBL1XR1</i> in Primary Central Nervous System Lymphomas (2012)

Our study provides new insights into the molecular tumorigenesis of PCNSL and identifies novel genetic alterations in this disease, especially MYD88 and TBL1XR1 mutations activating the NF-κB signaling pathway, which may be promising targets for future therapeutic strategies.
Premises: the Meandering Pathway to a State-of-the-art Building (2006)

The history of the successive premises occupied by the School could have been included in the previous chapter relating to the development of a quality culture. But the topic has played such a dominant role in the history of the School that it deserves a chapter on its own. More premises have been occupied than the School has had Deans! (See Box 12.1). Wigton House was a commercial block of six floors, mainly used as a warehouse (the site has now been re-developed but it was just south of the Walmsley building and shared a similar appearance). The Department of Education and Science authorised the College to lease the first floor of this building for five years from May 1964. This was the first home of the 'management group'. Plain breezeblocks were used to divide up the space into offices, classrooms and a psychological laboratory and workshop. While part-time management students in 1964 were somewhat taken aback by the premises, the staff accepted them in their stride. It was after all an improvement on the Nissen-type hut where some of the undergraduate teaching took place.
Archaeological Investigations at Pate (1997)

Pate est l'un des sites historiques culturels et archeologiques les plus importants de la cote d'Afrique orientale, situe au sud-ouest de l'ile de Pate, au nord de la cote du Kenya. L'importance du site tient a ce qu'il est l'un des plus anciens de la cote orientale de l'Afrique. L'archipel de Lamu etait le centre du monde swahili septentrional. Les recherches montrent que Pate participa au developpement de la culture swahili depuis les premiers temps (9e siecle apr. J.-C.) et devint l'une des communautes cotieres les plus prosperes du point de vue economique.
Transmitting terminal apparatus for NTSC color television (1953)

DURING the last few years several laboratories in the United States have been carrying on investigations directed toward supplementing the present monochrome television service with transmissions in color. In most cases these investigations of color television systems have been confined to proposals which were expected to receive the wide public acceptance which has characterized monochrome television. The probable commercial success of a color television system may be estimated by noting the degree to which it satisfies certain important criteria. One of these resides in the fact that the system should be “compatible.” That is, it is desirable, that television broadcasts in color should be reproduced in monochrome by the 20,000,000 odd black-and-white receivers now in the hands of the public without the necessity of modifying these receivers in any way. Second, in addition to providing full color to a color receiver, the system should provide as high a degree of pictorial definition to both monochrome and color receivers as is now realized in the monochrome service. Third, as a purely technical matter, the radio-frequency spectrum space allocated to the television service should be utilized as efficiently as possible. The color television system which is now being field-tested by the National Television System Committee (NTSC)1, 2 represents the results of these investigations. This system satisfies these criteria in large measure.
Roadside camera motion detection for automated speed measurement (2003)

In this paper, we present an algorithm to detect scene change that indicates that camera re-calibration is necessary. This work is in support of using un-calibrated traffic management roadside cameras for automated speed estimates. We construct an activity region using moving vehicle edges, and small differences in the activity region in consecutive images are used as a decision criteria for recalibrating the camera. The camera motion detection uses training sets of 10-second video sequences and detects moving vehicles using frame differencing. We present a validation of our algorithm using real-world traffic scenes.
Physiological and Molecular Approaches to Improve Drought Resistance in Soybean (2009)

Drought stress is a major constraint to the production and yield stability of soybean [Glycine max (L.) Merr.]. For developing high yielding varieties under drought conditions, the most widely employed criterion has traditionally been direct selection for yield stability over multiple locations. However, this approach is time consuming and labor intensive, because yield is a highly quantitative trait with low heritability, and influenced by differences arising from soil heterogeneity and environmental factors. The alternative strategy of indirect selection using secondary traits has succeeded only in a few crops, due to problems with repeatability and lack of phenotyping strategies, especially for root-related traits. Considerable efforts have been directed towards identifying traits associated with drought resistance in soybean. With the availability of the whole genome sequence, physical maps, genetics and functional genomics tools, integrated approaches using molecular breeding and genetic engineering offer new opportunities for improving drought resistance in soybean. Genetic engineering for drought resistance with candidate genes has been reported in the major food crops, and efforts for developing drought-resistant soybean lines are in progress. The objective of this review is to consolidate the current knowledge of physiology, molecular breeding and functional genomics which may be influential in integrating breeding and genetic engineering approaches for drought resistance in soybean.
Repeated measures in clinical trials: Analysis using mean summary statistics and its implications for design (1994)

This paper explores the use of simple summary statistics for analysing repeated measurements in randomized clinical trials with two treatments. Quite often the data for each patient may be effectively summarized by a pre-treatment mean and a post-treatment mean. Analysis of covariance is the method of choice and its superiority over analysis of post-treatment means or analysis of mean changes is quantified, as regards both reduced variance and avoidance of bias, using a simple model for the covariance structure between time points. Quantitative consideration is also given to practical issues in the design of repeated measures studies: the merits of having more than one pre-treatment measurement are demonstrated, and methods for determining sample sizes in repeated measures designs are provided. Several examples from clinical trials are presented, and broad practical recommendations are made. The examples support the value of the compound symmetry assumption as a realistic simplification in quantitative planning of repeated measures trials. The analysis using summary statistics makes no such assumption. However, allowance in design for alternative non-equal correlation structures can and should be made when necessary.
Subcellular localization and immunological detection of proteins encoded by the vir locus of Bordetella pertussis (1991)

The DNA sequence of the central regulatory locus vir of Bordetella pertussis predicts that three gene products, BvgA, BvgB, and BvgC, are encoded. Features of the predicted primary structures of these proteins and their homology to other two-component systems suggest that BvgA is located in the cytoplasm, BvgB is located in the periplasm, and BvgC spans the inner membrane. We have used gene fusions to the phoA and lacZ genes of Escherichia coli to investigate the subcellular localization and membrane topology of these proteins. PhoA fusion proteins were also purified and used to raise antibodies that allowed visualization of the vir-encoded polypeptides by Western immunoblotting. Our results have largely confirmed the predictions of the DNA sequence, with the exception that BvgB and BvgC were found to constitute one larger protein that was homologous to the sensor class of two-component systems. We propose that this protein be named BvgS (for sensor) and that its gene be named bvgS.
Synapses and Dendritic Spines as Pathogenic Targets in Alzheimer’s Disease (2012)

Synapses are sites of cell-cell contacts that transmit electrical or chemical signals in the brain. Dendritic spines are protrusions on dendritic shaft where excitatory synapses are located. Synapses and dendritic spines are dynamic structures whose plasticity is thought to underlie learning and memory. No wonder neurobiologists are intensively studying mechanisms governing the structural and functional plasticity of synapses and dendritic spines in an effort to understand and eventually treat neurological disorders manifesting learning and memory deficits. One of the best-studied brain disorders that prominently feature synaptic and dendritic spine pathology is Alzheimer's disease (AD). Recent studies have revealed molecular mechanisms underlying the synapse and spine pathology in AD, including a role for mislocalized tau in the postsynaptic compartment. Synaptic and dendritic spine pathology is also observed in other neurodegenerative disease. It is possible that some common pathogenic mechanisms may underlie the synaptic and dendritic spine pathology in neurodegenerative diseases.
Au-Coated Polystyrene Nanoparticles with High-Aspect-Ratio Nanocorrugations via Surface-Carboxylation-Shielded Anisotropic Etching for Significant SERS Signal Enhancement (2011)

Increasing the hot-spot area with high enhancement ability on SERS-active particles is generally acknowledged as one of the efficient ways to significantly improve the average SERS signal of nanoparticles. A method to create roughness on the surface of nanoparticles was proposed by oxygen plasma etching noncarboxylated polystyrene beads. However, the mechanism of nanocorrugation formation was not clear. Thus, in this paper, we employ argon-based reactive ion etching (RIE) incorporated with carboxylated polystyrene nanoparticles to investigate the roles of nanocorrugations’ morphologies for SERS signal enhancement. The formation mechanism of the nanocorrugations has been investigated thoroughly through a comparison with those formed by oxygen-based RIE processes from their high resolution X-ray photoelectron spectra and surface morphologies with or without hydrazine reduction treatment. Moreover, polystyrene beads with more intrinsic carboxyl groups and etched by argon plasma produce higher nanocorrugations. It is suggested that carbonyl groups with high bond energy become nanomasks on polystyrene bead surfaces and provides high selectivity between carboxyl and polystyrene surfaces under RIE. Raman intensity enhancement on a 20-nm gold coated nanocorrugated polystyrene bead array is summarized by three factors: (1) the effect of plasmonic coupling among neighboring particles, (2) the nanocorrugation-contributed roughness, and (3) the pitch size of nanocorrugations, through the analysis of SEM images, AFM height images, and LSPR signals. Among these factors, the pitch size of nanocorrugations (ranging from ∼6 nm to ∼12 nm on the surface of polystyrene beads) dominates the SERS enhancement. The 870 nm/120s oxygen plasma etched polystyrene beads (OPSBs) with a minimum pitch size of 6 nm provides the highest Raman intensity enhancement (measured by 632.8-nm He–Ne laser), which is 12 times greater than the intensity of nontreated (870 nm/0s) polystyrene beads (while the Au/Ti coating is 20 nm/5 nm).
Effect of diacylglycerol kinase inhibitor, R59022 on cytosolic free calcium level and force development in guinea pig taenia coli. (1993)

We previously described that carbachol (CCh) increased intracellular phosphatidic acid (PA) in guinea pig taenia coli and the increase was inhibited by diacylglycerol (DG) kinase inhibitor, R59022. The present study was conducted to clarify the role of DG kinase in CCh-induced increase in cytosolic free calcium and force development. Application of CCh to taenia coli induced transient increase in calcium level and contraction followed by sustained and lower calcium level and smaller contraction, and R59022 inhibited the latter responses specifically. The sustained responses were also evoked by 50 mM KCl, but these responses were slightly inhibited by R59022. Inhibition of calcium influx reduced responses to CCh but not KCl. Therefore, we consider that the sustained contraction induced by CCh is attributed to activation of DG kinase which generates PA and accelerates calcium influx.
Registration without correspondences (1994)

We present a method for registering images of complex 3D surfaces that does not require explicit correspondences between features across the images. Our method relies on the use of a full 3D model of the surface to adjust the position and orientation of the camera by minimizing an objective function based on the projections of the images onto the model. This approach constrains the camera parameters strongly enough so that the models do not need, initially, to be accurate to yield good results. When registration has been achieved, the models can be refined and the fine details recovered. Our method is applicable to the calibration of stereo imagery, the precise registration of new images of a scene and the tracking of deformable objects. It can therefore lead to important applications in fields such as augmented reality in a medical context or data compression for transmission purposes. We demonstrate its applicability by using images of faces and of terrain.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Good orders for incremental (re)construction (1997)

Article Good orders for incremental (re)construction Share on Authors: Jack Snoeyink Dept. of Computer Science, University of British Columbia Dept. of Computer Science, University of British ColumbiaView Profile , Marc van Kreveld Dept. of Computer Science, Utrecht University Dept. of Computer Science, Utrecht UniversityView Profile Authors Info & Claims SCG '97: Proceedings of the thirteenth annual symposium on Computational geometryAugust 1997 Pages 400–402https://doi.org/10.1145/262839.263025Online:01 August 1997Publication History 9citation276DownloadsMetricsTotal Citations9Total Downloads276Last 12 Months3Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Stress Magnitudes from Logs: Effects of Tectonic Strains and Temperature (1999)

Summary An improved method of calibrating in-situ stress logs was validated with data from two wells. Horizontal stress profiles are useful for hydraulic fracture design, wellbore stability analysis, and sand production prediction. The industry-standard method of estimating stresses from logs is based on overburden, Poisson's ratio, and pore pressure effects and gives an estimate of minimum horizontal stress. The model proposed here adds effects of temperature and tectonics and outputs of minimum and maximum horizontal stress magnitudes, which are particularly important to the successful completion of horizontal and deviated wells. This method was validated using data collected from a GRI research well and a Mobil well. Seven microfrac stress tests in GRI's Canyon Gas Sands Well of Sutton County, Texas, provided a means of comparing the predictive capability of different methods. First, one of the seven stress tests was selected as a calibration standard for the stress log. Then the results obtained from the two calibration methods were compared to stress magnitudes from the other six stress tests. This process was repeated using each of the seven stress tests as a calibration standard and comparing predictions to the other six. In every case, the method incorporating tectonic strain and thermal effects produced significantly more accurate values. The Mobil well is located in the Lost Hills Field in California, and pre-frac treatment breakdown tests were used to calibrate a log-derived stress profile. All of the data were used simultaneously to get a best fit for the log-derived stress. The log and its fracture height growth implications compared favorably with available fracture diagnostic data, and maximum horizontal stress values were consistent with published values for a similar, nearby reservoir.
Effect of gastroesophageal reflux disease on sleep (2010)

Recent studies have demonstrated a bidirectional relationship between gastroesophageal reflux disease (GERD) and sleep where night-time reflux leads to sleep deprivation and sleep deprivation per se can exacerbate GERD by enhancing perception of intra-esophageal stimuli. Presently, treatment has primarily focused on reducing night-time reflux and thus improving sleep quality. Future studies are needed to further explore the relationship between GERD and sleep and the potential of novel therapeutic options to interrupt the vicious cycle between GERD and sleep.
Books (1974)

B atten , L. et al . 1973. Birdwatchers' year. Pp. 351, 18 black and white photographs, numerous text‐figures. Berkhamsted C lancey , P. A. 1971. A handlist of the birds of southern Moqambique du P ont , J. E. 1971. Philippine birds F arner , D. S. & K ing , J. R. (Eds) & P arkes , K. C. (Taxonomic editor). 1972 T inbergen , N. 1973. The animal in its world W etmore , A. 1972. The birds of the Republic of Panami
LINNÆUS AS MEMBER OF THE SMÅLAND'S NATION AT UPPSALA—ASSERTED INTRIGUES AGAINST LINNÆUS—CHRISTMAS AT FALUN, 1734-35—JOURNEY ABROAD (2011)

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Optimization of modulation bandwidth in DBR lasers with detuned Bragg reflectors (1998)

The dynamical behavior of distributed Bragg reflector lasers with detuned Bragg reflectors is investigated theoretically. The model is based on the traveling wave equations, which are solved by expanding the solution in terms of the longitudinal eigenmodes. It is shown that for a drastic enhancement of the modulation bandwidth the interplay of the dominant mode and one side mode has to be enforced. Under these conditions, the modulation bandwidth can be enhanced to more than 70 GHz.
Dual efficient self-attention network for multi-target detection in aerial imagery (2020)

Aerial imagery target detection has been widely used in the military and economic fields. However, it still faces a variety of challenges. In this paper, we proposed several efficiency improvements based on YOLO v3 framework for getting a better small target detection precision. Firstly, a dual self-attention (DAN) block is embedded in Darknet-53’s ResNet units to refine the feature map adaptively. Furthermore, the deep semantic features are cascaded with the shallow outline features in a feedforward deconvolutional module to obtain context details of small targets. Finally, introducing online hard examples mining and combining Focal Loss to enhance the discriminating ability between classes. The experimental results on the VEDAI aerial dataset show that the proposed algorithm is significantly improved in accuracy compared to the original network and achieves better performance than two-stage algorithms.
Photochemistry of 1,<i>n</i>-Dibenzyloxy-9,10-anthraquinones (2010)

The photochemistry of a series of 9,10-anthraquinones with multiple benzyloxy substituents was investigated. In polar solvent, the expected Blankespoor oxidative cleavage reaction is the major reaction pathway, but in most cases, several minor products were observed. In nonpolar solvents, the abundance of these minor products increases dramatically. Four types of product were observed with the favored reaction pathway shifting with minor changes in substitution on the anthraquinone. Several types of product require cleavage of the C-O bond on the benzyloxy group and, apparently, follow a photo-Claisen-type mechanism. Others involve the expected 1,5-diradical but do not exhibit the single-electron transfer usually observed in the Blankespoor-type reaction. The results indicate the importance of considering the medium and photoredox behavior in anthraquinone photochemistry.
Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein α subunit Gα13 (1998)

Signal transduction pathways that mediate activation of serum response factor (SRF) by heterotrimeric G protein alpha subunits were characterized in transfection systems. Galphaq, Galpha12, and Galpha13, but not Galphai, activate SRF through RhoA. When Galphaq, alpha12, or alpha13 were coexpressed with a Rho-specific guanine nucleotide exchange factor GEF115, Galpha13, but not Galphaq or Galpha12, showed synergistic activation of SRF with GEF115. The synergy between Galpha13 and GEF115 depends on the N-terminal part of GEF115, and there was no synergistic effect between Galpha13 and another Rho-specific exchange factor Lbc. In addition, the Dbl-homology (DH)-domain-deletion mutant of GEF115 inhibited Galpha13- and Galpha12-induced, but not GEF115 itself- or Galphaq-induced, SRF activation. The DH-domain-deletion mutant also suppressed thrombin- and lysophosphatidic acid-induced SRF activation in NIH 3T3 cells, probably by inhibition of Galpha12/13. The N-terminal part of GEF115 contains a sequence motif that is homologous to the regulator of G protein signaling (RGS) domain of RGS12. RGS12 can inhibit both Galpha12 and Galpha13. Thus, the inhibition of Galpha12/13 by the DH-deletion mutant may be due to the RGS activity of the mutant. The synergism between Galpha13 and GEF115 indicates that GEF115 mediates Galpha13-induced activation of Rho and SRF.
Chloride Corrosion of Steel in Concrete (1977)

Description The symposium on Chloride Corrosion of Steel in Concrete was presented at the Seventy-ninth Annual Meeting of the American Society for Testing and Materials held in Chicago, Ill., 27 June-2 July 1976. Committee G01 on Corrosion of Metals sponsored the symposium. D. E. Tonini, American Hot Dip galvanizers Association, Inc., and S. W. Dean, Jr., Air Products and Chemicals, Inc., presided as symposium cochairmen and also as editors of this publication.
Current distribution control for parallel connected converters. I (1992)

For pt.II, see ibid., vol.28, no.3, p.841-851 (1992). A master-slave control scheme for a uniform current distribution among converter modules in a parallel connected system is presented. In this technique, inner current loops are introduced to the system to achieve output current equalization. The current distribution error is used as a criterion for judging system performance. Using this control scheme, the current distribution error can be reduced greatly even with nonidentical converters in the system. To optimize system efficiency and facilitate the fault-tolerant algorithm realization, this technique is refined so that only the necessary number of converters are activated for different load conditions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>