gebhart/patrepeval huggingface dataset:
Effect of Antineoplastic Agents on the Growth and Ultrastructure of Candida Albicans (1984)

Summary: The effect of four antineoplastic agents 1) on the growth and ultrastructure of the yeast Candida albicans was investigated. Growth and MIC studies showed that two of the four drugs produced inhibition, with thiotepa being more active than methotrexate. Furthermore, SEM studies showed that both these drugs caused morphological changes. Methotrexate induced germtube production resulting in transformation from the yeast to hyphal form. Thiotepa caused cell lysis. The other two drugs, VIS and ENA, caused little or no significant alterations in gross morphology and no growth inhibition. It is proposed that these drugs affect cellular DNA but in subtly different ways resulting in different manifestations on growth and morphology. The frequent occurrence of aberrant filamentous yeasts from cancer patients may be due to the result of chemotherapy. Zusammenfassung: Die Wirkung der vier zytostatischen Präparate Methotrexat (MET), Thiotepa (THT), Vincristinsulfat (VIS) and Endoxan‐Asta (ENA) auf Wachstum und Feinstruktur der Hefe Candida albicans wurde untersucht. Untersuchungen des Wachstums und MHK‐Bestimmungen ergaben Hemmreaktionen bei zwei der vier Präparate, wobei Thiotepa stärkere Aktivität zeigte als Methotrexat. Darüber hinaus zeigten SEM‐Untersuchungen morphologische Veränderungen, die durch diese Präparate verursacht worden waren. Methotrexat induzierte die Keünschlauchbildung und damit eine Konversion von der Blastosporen‐ in die Pseudomyzelform. Thiotepa verursachte eine Lyse der Zellen. Die beiden anderen Präparate VIS and ENA zeigten nur geringe oder keine signifikanten Veränderungen in der Gesamtmorphologie und keine Wachstumshemmung. Die Ergebnisse werden so gedeutet, daß diese Präparate die zelluläre DNS in verschiedener Weise beeinflussen, was zu unterschiedlichen Veränderungen in Wachstum und Morphologie führt. Das häufige Vorkommen anomaler hyphenbildender Hefen bei Karzinompatienten mag eine Folge der chemotherapeutischen Behandlung sein.
No Unlabeled Containers Anywhere, Ever! Where Did this Come From? (2015)

These medication errors have occurred in health care facilities at least once. They will happen again-perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site (www.ismp.org), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org. ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.
Intracoronary Stents in Heart Transplant Patients who Develop Transplant Coronary Artery Disease: What is the Restenosis Rate? (1999)

381 Transplant coronary artery disease is a major factor limiting long-term survival in heart transplant patients. There is no successful treatment for this disease; however, angioplasty may be feasible in a selected subgroup of these patients. From the multicenter angioplasty registry, restenosis after angioplasty (without stents) is 55% at 4 months. Restenosis after angioplasty in non-transplant patients has been found to be reduced from 30% to 20% with the use of stents, but the restenosis rate for stent placement in transplant patients has not been well studied. Therefore, we evaluated 9 heart transplant patients undergoing angioplasty and stent placement for coronary lesions > 70% between January 1996 and December 1997. Two of the 9 patients died despite successful angioplasty and stenting within 1 month of the procedure. These 2 patients also had severe distal pruning on angiography. Autopsy revealed the stents to be open. In the other 7 patients, successful angioplasty and stent placement was also achieved (lesion reduced to < 30%). There was no significant restenosis (> 70%) in any of the stented regions in follow-up angiogram at any time between 6 and 24 months (see table, numbers are cumulative).TableConclusion: Angioplasty with stent placement appears to reduce restenosis in selected cardiac transplant patients with transplant coronary artery disease. Severe distal small vessel disease appears to be a marker for poor outcome despite successful angioplasty/stenting.
9/11, Elitism or Post-Modernism (2017)

This paper will evaluate the way the events of 9/11 were interpreted. The evaluation will use two perspectives: Elitism and Post-modernism. The paper is structured as follows. After a short description of the events the concept of elitism is introduced. After that the focus moves on what disaster problems were identified after 9/11 from an elitist perspective, what policies this generated and what was the outcome of these policies. This same structure is kept in place in the second part of the paper where a similar evaluation happens, this time using post-modernism as a lens. The paper concludes that the two perspectives are complementary and proposes a solution grounded in cognitive psychology to what it sees as an issue of there being too many benefits associated with the creation of certain metanarratives.
Brain Stem Auditory Evoked Potentials in Posterior Circulation Surgery (1983)

The objectives of this study were to evaluate the use of brain stem auditory evoked potentials (BAEPs) in 10 adult patients with vascular disorders of the posterior circulation that were treated surgically and to compare the BAEPs with the neurological findings. The vascular lesions included basilar artery stenosis in 3 patients, vertebral artery stenosis in 1 patient, brain stem/cerebellar arteriovenous malformation in 2 patients, and basilar artery aneurysm in 4 patients. Measurement of BAEPs were carried out during operation in all cases. Eight patients had BAEPs measured before operation, and 9 patients had BAEPs measured after operation. Repeat postoperative studies were performed in patients with changes in neurological status. In general, BAEP abnormalities correlated with the neurological findings before and after operation. Six patients had normal intraoperative studies. None of them had clinical findings of pontomesencephalic dysfunction after operation. Three patients with significant BAEP abnormalities during operation had neurological findings of pontomedullary ischemia after operation. Transient BAEP changes in 1 patient were thought to be the result of brain stem retraction. The BAEPs were lost in 3 patients who died. The use of BAEP measurement did not lengthen the operative procedures. However, the technique used in this study required 4 to 8 minutes for the accumulation and interpretation of each average, thereby delaying feedback to the surgeon. The results of this study suggest a potential role for BAEP monitoring in identifying brain stem injury during posterior circulation surgery.
Nature of Growth Inhibitor in Some Mammalian Sera For Pleuro-pneumonia-Like Organisms of Human Origin (1953)

Bovine alpha-globulin (bovine plasma fraction IV, Armour) in the presence of guinea pig complement inhibits the growth of the pleuropneumonia-like organisms. Heat-inactivated bovine serum is slightly inhibitory but the alpha-, beta-, and gamma-globulins are non-inhibitory in the absence of complement. Complement by itself does not inhibit growth as extensively as when in the presence of globulin. Alpha-globulin in the presence of the organisms fixes complement in low titer.
Ultrasonic aerosol concentration and positioning (2015)

AccessScience is an authoritative and dynamic online resource that contains incisively written, high-quality educational material covering all major scientific disciplines. An acclaimed gateway to scientific knowledge, AccessScience is continually expanding the ways it can demonstrate and explain core, trustworthy scientific information that inspires and guides users to deeper knowledge.
The effect and problem of multimedia teaching (2007)

Multimedia teaching have become a advanced teaching mode,and being used more and more widely in the course of teaching,because it can offer letter, picture,sound,flash and so on.Expatiated the effect of Multimedia teaching,discussed the problems developing,and proposed that we should know aright the station of Multimedia teaching inwardly.
AN ANTIMALARIAL ALKALOID FROM HYDRANGEA. X. SYNTHESIS OF 3-[β-KETO-γ-(4-METHYL-2-PYRROLIDYL)PROPYL]-4-QUINAZOLONE (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAN ANTIMALARIAL ALKALOID FROM HYDRANGEA. X. SYNTHESIS OF 3-[β-KETO-γ-(4-METHYL-2-PYRROLIDYL)PROPYL]-4-QUINAZOLONEB. R. BAKER, ROBERT E. SCHAUB, and JAMES H. WILLIAMSCite this: J. Org. Chem. 1952, 17, 1, 109–115Publication Date (Print):January 1, 1952Publication History Published online1 May 2002Published inissue 1 January 1952https://pubs.acs.org/doi/10.1021/jo01135a011https://doi.org/10.1021/jo01135a011research-articleACS PublicationsRequest reuse permissionsArticle Views707Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
How we do business (or, why does it take other journals so long to review your paper?) (2008)

Have you ever wondered why it takes so long to get comments back from reviewers at some journals? After all, how long should it take to review a paper? I suspect most of us have asked this question at one time or another. While recently contemplating this, I thought it was time to tell you a little about how we run Autophagy, and at the same time compare it to the practices at some other journals where I have, on occasion (notably before the start of Autophagy), sent my own papers.
Berichtigung: Rhodium‐Catalyzed Asymmetric Synthesis of Silicon‐Stereogenic Dibenzosiloles by Enantioselective [2+2+2] Cycloaddition (2015)

In Abbildung 1 dieser Zuschrift sind die Werte an der senkrechten Achse um den Faktor 10 zu niedrig; die korrigierte Abbildung ist hier gezeigt. Entsprechend muss die zugehörige Textpassage auf S. 1638 (linke Spalte, zweiter Absatz) wie folgt lauten: CD spectra of (R)-3 aa (gray line; 1.1×10−5 M) and (R,R)-9 (black line; 5.7×10−6 M) in CH2Cl2 at 25 °C. “We also examined the CD spectra of these compounds and found that (R)-3 aa showed a relatively weak negative Cotton effect at λ=259 nm (Δε=−30 M−1 cm−1), whereas (R,R)-9 showed stronger positive and negative Cotton effects at λ=282 nm (Δε=+73 M−1 cm−1) and λ=256 nm (Δε=−108 M−1 cm−1), respectively (Figure 1).” Diese Berichtigung ändert nichts an den Schlussfolgerungen der Zuschrift.
Biological Relevance and Therapeutic Potential of the Hypusine Modification System (2015)

Hypusine modification of the eukaryotic initiation factor 5A (eIF-5A) is emerging as a crucial regulator in cancer, infections, and inflammation. Although its contribution in translational regulation of proline repeat-rich proteins has been sufficiently demonstrated, its biological role in higher eukaryotes remains poorly understood. To establish the hypusine modification system as a novel platform for therapeutic strategies, we aimed to investigate its functional relevance in mammals by generating and using a range of new knock-out mouse models for the hypusine-modifying enzymes deoxyhypusine synthase and deoxyhypusine hydroxylase as well as for the cancer-related isoform eIF-5A2. We discovered that homozygous depletion of deoxyhypusine synthase and/or deoxyhypusine hydroxylase causes lethality in adult mice with different penetrance compared with haploinsufficiency. Network-based bioinformatic analysis of proline repeat-rich proteins, which are putative eIF-5A targets, revealed that these proteins are organized in highly connected protein-protein interaction networks. Hypusine-dependent translational control of essential proteins (hubs) and protein complexes inside these networks might explain the lethal phenotype observed after deletion of hypusine-modifying enzymes. Remarkably, our results also demonstrate that the cancer-associated isoform eIF-5A2 is dispensable for normal development and viability. Together, our results provide the first genetic evidence that the hypusine modification in eIF-5A is crucial for homeostasis in mammals. Moreover, these findings highlight functional diversity of the hypusine system compared with lower eukaryotes and indicate eIF-5A2 as a valuable and safe target for therapeutic intervention in cancer.
INTRAOCULAR INTRUSION OF SUTURES AFTER RETINAL DETACHMENT BUCKLING SURGERY (1995)

Intrusion of sutures into the eye can rarely be seen years after retinal detachment surgery and usually do not require surgical intervention. When hemorrhage occurs, cutting of the silicone band only, with no attempt to remove the band or the sutures, is recommended.
A Review of Clinical Outcome Assessment Instruments for Gait, Balance, and Fall Risk in Persons With Lower Extremity Amputation (2013)

Lower extremity amputation is known to compromise gait, balance, and overall capacity to react to slips and trips. Given an estimated 1.8 million persons in the United States living with limb loss with an expectation for this number to double by the year 2050, the need for rehabilitative care providers to evaluate and develop treatment plans to minimize the potential for falls will surely rise. Objective measurement of fall risk and evaluation of the effect of targeted treatment interventions are essential to enhancing the quality of rehabilitative care. As a means to this end, the development and use of objective outcome measures that are relevant to the amputee population are necessary. The purpose of this article is to identify and describe these tools and critically review their respective clinical strengths and limitations.
Markovian Quadratic Term Structure Models For Risk-free And Defaultable Rates (2003)

Abstract. In this paper, a class of regular quadratic Gaussian processes is defined to characterize quadratic term structure models (QTSMs) in a general Markovian setting. The primary motivation for this definition is to provide a more general model for the quadratic term structure of the forward curve, while maintaining the analytical tractability of the traditional QTSMs. It is demonstrated that the tractability of QTSMs does not necessarily rely on the Ornstein-Uhlenbeck state processes used in their traditional definition. Rather, the crucial element that provides analytical solutions for the prices of zero-coupon bonds and their options is a so-called quadratic Gaussian property as defined in this paper. In order to retain this property for a general Markov process, it is shown that, under the regularity conditions, no jumps are allowed in the infinitesimal generator of the process. It is further shown that the coefficient functions defined in the quadratic Gaussian property can be determined by multi-variate Riccati equations with a unique admissible parameter set. The implications of this result for modeling the term structure of risk-free rates and defaultable rates are discussed. Key words and phrases. Quadratic term structure models, option pricing, defaultable rates, timehomogenous Markov processes. We are indebted to Damir Filipović not only for initiating the study of affine processes but also for his comments and suggestions on some proofs in this paper.
Rock bolt behaviour in stress-fractured ground: a FE analysis using zero-thickness interface elements and fracture-based constitutive laws (2016)

A finite element analysis using zero-thickness interface elements of the Goodman type, which incorporate a fracture mechanics-based mixed-mode constitutive law, is presented to study stress-induced cracking and spalling around a highly stressed tunnel. The effect of bolting on stress-fracturing and rock mass deformations (strains of the rock matrix and opening/sliding of the fractures) is considered by applying bolts at various spacing densities. The adopted tunnel excavation and far-field loading sequence approximates conditions typically experienced at the extraction level of a caving operation. Starting from an in situ stress state, the tunnel is excavated and then loaded vertically to simulate the advancement of the overlying undercut. The tunnel is then unloaded to stress values lower than in-situ once the undercut becomes effective and caving begins.\nUsing a Voronoi tessellation routine, the rock mass near the tunnel cross-section is randomly discretized into triangular elements of similar size to that expected for spalled rock blocks. Interface elements are inserted in between all mesh lines. An interface transitioning to the far-field rock mass separates this finely-discretized zone allowing the rest of the cross-section to be modelled as a linear elastic material for computational efficiency. Rock bolts are simulated in a simplified manner with elasto-plastic rod elements overlapped to the continuum mesh and anchored at several points along their length including the ends. Calculations are run using various bolt spacing densities. The model results show bulking due to stress-fracturing of strong rock. They further show that bulking can only be reduced, but not prevented, through confinement provided by high bolting forces.
A direct hybrid finite element- wave based prediction technique for the steady-state dynamic analysis of twe-dimensional solids (2005)

This paper reports on the development of a novel hybrid finite element-wave based prediction technique for the steady-state dynamic analysis of two-dimensional structural solids. This method combines the computational efficiency of the wave based method with the geometrical flexibility of the finite element method and, therefore, it has the potential to become a computationally efficient and generally applicable alternative for the finite element method, especially in the mid-frequency range.
New solvents for Electroplating (1988)

SummaryThe often conflicting requirements of non-aqueous electroplating baths are examined and studies of mixtures of benzene or anisole with biphenyl, naphthalene and phenanthrene discussed.
Evaluation of package and technology effects on substrate-crosstalk isolation in CMOS RFIC (2003)

Crosstalk propagating through the silicon substrate is a serious limiting factor on the performance of advanced mixed analog-digital CMOS integrated circuits. This problem also appears in RF chips in the form of power leakage from local oscillators or power amplifiers, as well as the noise coupled from the digital baseband circuitry. Several studies have presented measurements on simple test structures to determine the best approach to minimize this leakage. Nevertheless, these studies are usually restricted to a single technology, and the consequences of applying results to other technologies are not evaluated. Also, these studies are usually performed with on-wafer samples, and thus package effects are not taken into account. However, package parasitics are an important factor in the substrate crosstalk, since they determine how much of the leakage finds a return path to external ground. In this paper, we discuss different technological approaches to increase isolation between coupled circuits. Measurements of the isolation on some test structures fabricated in a CMOS RF technology are presented. The package parasitics effect is evaluated by comparing on-wafer vs packaged samples. Measurement results are complemented with simulations of a broader range of situations.
Characterization of branching architecture through "universal" ratios of polymer solution properties (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of branching architecture through "universal" ratios of polymer solution propertiesJack F. Douglas, Jacques Roovers, and Karl F. FreedCite this: Macromolecules 1990, 23, 18, 4168–4180Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/ma00220a022https://doi.org/10.1021/ma00220a022research-articleACS PublicationsRequest reuse permissionsArticle Views1133Altmetric-Citations297LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Finite element formulation for a baffled, fluid‐loaded, finite cylindrical shell (1994)

Abstract A new method for obtaining the response of a baffled, fluid‐loaded, finite cylindrical shell using the finite element method is presented. The Galerkin finite element formulation for this problem utilizes a Neumann Green's function representation of the pressure loading on the shell. By representing the pressure loading in this manner, only the structure need be discretized. Both 𝒞 0 and 𝒞 1 finite element discretizations of the shell are considered. The finite element results are compared with the analytic solutions of the fluid‐loaded cylinder which are obtained using an expansion of the displacement in terms of the in vacuo modes of the Naghdi–Cooper and Flügge shell theories.
Churches as targets for cardiovascular disease prevention: comparison of genes, nutrition, exercise, wellness and spiritual growth (GoodNEWS) and Dallas County populations (2012)

Compared with African-Americans in Dallas County, CBPR participants in church congregations were more educated, physically active and had more treatment and control of most CVRFs. Surprisingly, this motivated population had a greater obesity burden, identifying them as a prime target for CBPR-focused obesity treatment.