gebhart/patrepeval huggingface dataset:
Molecular Cytogenetic Analysis of RB-1 Deletions in Chronic B-Cell Leukemias (1994)

Deletions or translocations of 13q, most commonly involving band 13q14, belong to the most frequent structural chromosome abnormalities in B-cell chronic lymphocytic leukemia (B-CLL). In a combined metaphase and interphase cytogenetic study using conventional G-banding analysis and fluorescence in situ hybridization (ISH) we previously analysed the retinoblastoma susceptibility gene (RB-1) and its chromosomal locus 13q14 in 35 patients with chronic B-cell leukemias. We report here on the interphase cytogenetic analysis of 109 cases with chronic B-cell leukemias [B-CLL = 90; B-prolymphocytic leukemia (B-PLL) = 6, hairy cell leukemia (HCL) = 13]; a subset of 49 patients (B-CLL = 45; B-PLL = 4) was studied by conventional G-banding analysis. By G-banding, 5/45 (11%) patients with B-CLL had deletions or translocations affecting band 13q14; in contrast, ISH to interphase cells showed RB-1 deletion in 19/90 (21%) patients with B-CLL. No 13q14 abnormalities or RB-1 deletion were detected in patients with B-PLL and HCL. Our data confirm the high frequency of RB-1 deletions in B-CLL and further emphasize the possible pathogenetic role of this genomic region.
ChemInform Abstract: Domino Iron Catalysis: Direct Aryl—Alkyl Cross‐Coupling. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
<title>True-Depth: a new type of true 3D volumetric display system suitable for CAD, medical imaging, and air-traffic control</title> (1998)

Floating Images, Inc. is developing a new type of volumetric monitor capable of producing a high-density set of points in 3D space. Since the points of light actually exist in space, the resulting image can be viewed with continuous parallax, both vertically and horizontally, with no headache or eyestrain. These 'real' points in space are always viewed with a perfect match between accommodation and convergence. All scanned points appear to the viewer simultaneously, making this display especially suitable for CAD, medical imaging, air-traffic control, and various military applications. This system has the potential to display imagery so accurately that a ruler could be placed within the aerial image to provide precise measurement in any direction. A special virtual imaging arrangement allows the user to superimpose 3D images on a solid object, making the object look transparent. This is particularly useful for minimally invasive surgery in which the internal structure of a patient is visible to a surgeon in 3D. Surgical procedures can be carried out through the smallest possible hole while the surgeon watches the procedure from outside the body as if the patient were transparent. Unlike other attempts to produce volumetric imaging, this system uses no massive rotating screen or any screen at all, eliminating down time due to breakage and possible danger due to potential mechanical failure. Additionally, it is also capable of displaying very large images.
Magnetic exchange between Ti3+ ions in titanium phosphate glass (1979)

Magnetic properties of reduced titanium phosphate glasses are reported. Magnetic susceptibility measurements from 1.0° to 400°K indicates behavior typical for amorphous antiferromagnetism. The more reduced glasses show an anomalous field dependence in the susceptibility suggestive of ferromagnetism. A microstructural model for the glasses is developed from physical, chemical and magnetic data. Using the model, a theoretical magnetic susceptibility equation is derived. The equation includes contributions to a total susceptibility from isolated Ti(3+) ions and ion pairs which participate in exchange. From electron spin resonance results, the theoretical susceptibility equation and the experimental Ti(3+) ion concentration in the glasses, a good fit to the experimental magnetic susceptibility data is obtained. Results from the theoretical equation indicates that ferromagnetic and antiferromagnetic interaction between exchange-coupled Ti(3+) ions may occur. At low temperatures a downward curve toward the origin of the inverse susceptibility is predicted which is consistent with the experimental data.
<i>Globularia alypum</i> L. extracts reduced histamine and serotonin contraction<i> in vitro</i> (2002)

The present study analyses in in vitro models the pharmacological activity of methanol and dichloromethane extracts (1, 10 and 100 microg/mL) obtained from the leaves and stems of Globularia alypum L. Preincubation of the guinea-pig ileum and rat uterus with both extracts produced a dose dependent abolition of the contractile effects of histamine and serotonin, respectively. At the same doses, neither methanol nor dichloromethane extract reduced the contractile effects of acetylcholine on rat duodenum or noradrenaline on rat vas deferens.
THE FORMATION OF EXTRACELLULAR PROTEOLYTIC ENZYMES BY <i>STAPHYLOCOCCUS AUREUS</i> (1973)

Three different proteolytic enzymes could be identified in supernatants from cultures of Staphylococcus aureus , strain V8, if grown in a casein hydrolysate‐yeast extract medium (CCY I ). One protease was not produced if the yeast extract was omitted from the medium. This protease was inactivated by ethylene‐diamino‐tetra‐acetic acid (EDTA, 5.0 mM at 20° C for 30 min). If calcium ions (final cone. 2.5 mM) were added to the yeast extract‐free medium, the EDTA‐sensitive protease was formed in amounts approaching those obtained in the complete medium. The formation of the EDTA‐stable enzymes was not affected by calcium ions. The two EDTA‐stable activities could be separated by isoelectric focusing, one with a pI of 4.0 and the other with a pI of 9.4. The formation of the EDTA‐stable protease was stimulated by yeast extract.
A transition radiation detector for RHIC featuring accurate tracking and dE/dx particle identification (2008)

We describe the results of a test ran involving a Transition Radiation Detector that can both distinguish electrons from pions which momenta greater titan 0.7 GeV/c and simultaneously track particles passing through the detector. The particle identification is accomplished through a combination of the detection of Transition Radiation from the electron and the differences in electron and pion energy loss (dE/dx) in the detector. The dE/dx particle separation is most, efficient below 2 GeV/c while particle ID utilizing Transition Radiation effective above 1.5 GeV/c. Combined, the electron-pion separation is-better than 5 {times} 10{sup 2}. The single-wire, track-position resolution for the TRD is {approximately}230 {mu}m.
Dermoscopy and the Diagnostic Challenge of Amelanotic and Hypomelanotic Melanoma (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
[Invasive pneumococcal disease in Poland in 2010]. (2011)

Results of the study showed high theoretical coverage of pneumococcal conjugate vaccines among IPD cases in general and especially among infections caused by isolates with decreased susceptibility to antibiotics. Therefore, it seams that the best way to limit invasive pneumococcal disease-associated morbidity and mortality, especially of cases caused by bacteria with decreased susceptibility to antibiotics, is the inclusion of a PCV in the immunization programme in Poland.
ATP signalling in epilepsy (2008)

This paper focuses on a role for ATP neurotransmission and gliotransmission in the pathophysiology of epileptic seizures. ATP along with gap junctions propagates the glial calcium wave, which is an extraneuronal signalling pathway in the central nervous system. Recently astrocyte intercellular calcium waves have been shown to underlie seizures, and conventional antiepileptic drugs have been shown to attenuate these calcium waves. Blocking ATP-mediated gliotransmission, therefore, represents a potential target for antiepileptic drugs. Furthermore, while knowledge of an antiepileptic role for adenosine is not new, a recent study showed that adenosine accumulates from the hydrolysis of accumulated ATP released by astrocytes and is believed to inhibit distant synapses by acting on adenosine receptors. Such a mechanism is consistent with a surround-inhibitory mechanism whose failure would predispose to seizures. Other potential roles for ATP signalling in the initiation and spread of epileptiform discharges may involve synaptic plasticity and coordination of synaptic networks. We conclude by making speculations about future developments.
Quantitative Assessment of Penetration Depth in Clinical Ultrasound Systems (2007)

Most of the recent studies for image uniformity assessment involve signal to noise ratio (SNR) analysis computed over various combinations of mean grey level and variance [1–2] to quantify the speckle contrast and hence the depth of penetration (DOP). Speckle is auto correlated in time but not in space. Electronic noise always present at the bottom of the image, instead, is uncorrelated both in time and space. The extension of the area in which only the speckle is visible, gives an estimate of the penetration depth. The correlation coefficient of two subsequently acquired frames can be computed to quantify image uniformity where depth at which the correlation coefficient falls below a fixed threshold is defined as penetration depth.
Dynamic Modelling of the Diffusion in A Dyeing Process, Part II: Temperature Influence (2004)

This paper is the second one dealing with the mathematical modelling of the diffusion during a dyeing process. In the first paper [1], a mathematical model describing the diffusion coefficient evolution as a function of time, initial dye concentration, and dyebath nature was proposed. This model applies to the dyeing of polyester fibres with disperse dyes. The influence of temperature variations on the diffusion coefficient is the main subject of this second paper. First, a more accurate method for the diffusion coefficient computation is developed, leading to improvements of the previous model. Then, this model is reconsidered (completed), including the temperature variations influence and finally, it is tested and validated with a dyeing experiment having an imposed temperature profile.
The Changing Presentation of the American Indian : Museums and Native Cultures (2004)

In this book, which grew out of a landmark NMAI symposium in 1995, Native and non-Native scholars and museum professionals explore issues concerning the representation of Indians and their cultures by museums in North America. Traditional museum exhibitions of Native American art and culture often represented only the past, ignoring the living Native voice. Today, museums have begun to incorporate the Native perspective in their displays. Even more dramatic is the increasing number of Indian-run museums. These essays explore the relationships being forged between museums and Native communities to create new techniques for presenting Native American culture.
An FPGA-based high-speed emulation system for powerline channels (2005)

The development and test of powerline communication (PLC) systems require standardized test beds that allow the real-time emulation of channels in the laboratory. Typical powerline channel properties, such as transfer function and the noise scenario must be covered. This paper presents the development of a system to perform these tasks.
Effects of Angiotensin Converting Enzyme Inhibition (1985)

Angiotensin converting enzyme inhibitors were developed to prevent the in vivo generation of angiotensin II and thereby to reduce peripheral vasoconstriction. However, these compounds exert some additional effects that may or may not be angiotensin dependent. These include potential sodium diuresis, bradykinin accumulation, prostaglandin release, blunting of sympathetic activity, parasympathomimetic actions, central effects, redistribution of blood flow toward some particularly important organs. Only the comprehensive assessment of the many complex interactions that exist between the renin-angiotensin and several other regulatory systems reveals the complete therapeutic profile of this class of pharmacologic agents.
Hexavalent Americium<sup>1</sup> (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHexavalent Americium1L. B. Asprey, S. E. Stephanou, and R. A. PennemanCite this: J. Am. Chem. Soc. 1951, 73, 12, 5715–5717Publication Date (Print):December 1, 1951Publication History Published online1 May 2002Published inissue 1 December 1951https://pubs.acs.org/doi/10.1021/ja01156a065https://doi.org/10.1021/ja01156a065research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quality of life in young adult patients treated for bladder exstrophy. (2016)

Age and gender were not predictors of better QOL scores. Any clinical impairment, such as urinary leakage due to incontinence or fistula, penile length and infertility, tended to significantly decrease the overall QOL in male patients with BE. The male genitalia seems to be the most troublesome aspect post-adolescence in treated male patients with exstrophy-epispadias. It has an important impact on the overall QOL, mainly having a social affect on those patients.
Trends in Severe Pediatric Emergency Conditions in a National Cohort, 2008 to 2014 (2018)

The most common serious condition in children presenting to United States emergency departments is serious respiratory disease. Anaphylaxis is the fastest increasing serious condition. Additional research attention to these diagnoses is warranted.
Some reactions of 1-methyl-1,2-dihydropyridines with organic azides. Synthesis and reactions of 1,2,5,6-tetrahydropyridylidene-2-cyan(sulfon)amides and piperidylidene-2-cyan(sulfon)amides (1985)

The regiospecific 1,3-dipolar cycloaddition reaction of 1,2-dihydropyridines 2 with organic azides 3 affords 2,7-diazabicyclo[4.1.0]hept-4-enes 4. Treatment of 4a with neutral aluminum oxide opened the aziridine ring to afford the 1,2,5,6-tetrahydropyridylidene-2-cyanamide 5. Catalytic hydrogenation of 4 and 5 using palladium-on-charcoal and hydrogen yielded the 1-methyl-2-piperidylidenes 6. Oxidation of 1-methyl-1,2,5,6-tetrahydropyridylidene-2-cyanamide (5) with alkaline hydrogen peroxide yielded the oxirane 7 arising from epoxidation of the 3,4-olefenic bond, whereas oxidation of the bicyclic aziridine 4a with m-chloroperbenzoic acid resulted in epoxidation of the 4,5-olefenic bond and opening of the aziridine ring to give the oxirane 3-methyl-3-aza-7-oxabicyclo[4.1.0]heptylidene-4-cyanamide (10). Base-catalyzed abstraction of the C-3 proton of 1-methyl-2-piperidylidenes 6 yielded the 3-lithio analogs which, after bromination, were converted to the target compounds 18 upon condensation with 4-[(2-aminoethyl)thiomethyl]-5-methylimidazole.
Nephrotoxic Action of Spermine (1952)

Spermine administered parenterally is highly active in producing renal injury in mice, rats, and rabbits. This property was not observed for spermidine, putrescine, or cadaverine.
Novel Cooled Sliding Chamber Elucidates Origins of Action Potential Modulated Birefringence (2010)

A specimen chamber for crustacean nerve experiments was newly designed to maintain physiological temperatures and allow observation along the length of the specimen. The resulting data elucidate the origins of action potential-induced changes in birefringence.
Echocardiographic screening results in patients with tuberous sclerosis complex. (2010)

We sought to examine the frequency of abnormal echocardiographic findings in patients with tuberous sclerosis complex. In a retrospective cohort study, we included all patients with known tuberous sclerosis complex who had been sent to our cardiology department for echocardiographic screening from 1995 through August 2003 (n=56). Two research scientists independently reviewed the reports of the echocardiographic screening examinations for abnormal findings. We used descriptive statistics, the Mann-Whitney U test, and the chi(2) test. The mean age of patients included in the study was 35 years (range, 12-73 yr); 23 patients were male. Abnormal findings were seen in 22 patients (39%). The most common abnormal findings were focal areas of increased intramyocardial echogenicity, which were seen in 16 patients (29%). The clinical consequence of this finding is still unknown. We conclude that echocardiographic abnormalities are common in patients with tuberous sclerosis complex.
An LDA investigation of three-dimensional normal shock-boundary layer interactions in a corner (1987)

Nonintrusive, three-dimensional, measurements have been made of a normal shock wave-turbulent boundary layer interaction. The measurements were made in the corner of the test section of a continuous supersonic wind tunnel in which a normal shock wave had been stabilized. LDA, surface pressure measurement and flow visualization techniques were employed for two freestream Mach number test cases: 1.6 and 1.3. The former contained separated flow regions and a system of shock waves. The latter was found to be far less complicated. The reported results are believed to accurately define the flow physics of each case and may be used as benchmark data to verify three-dimensional computer codes.
Identification of CRF34_01B, a Second Circulating Recombinant Form Unrelated to and More Complex Than CRF15_01B, among Injecting Drug Users in Northern Thailand (2007)

In Thailand, the circulating HIV-1 strains include CRF01_AE, subtype B, and their recombinants. Genotyping and full-genome sequencing had previously identified circulating recombinant form CRF15_01B within a cohort of 347 HIV-1-infected individuals enrolled in the Opiate Users Research (OUR) study in northern Thailand. Using an improved MHAbce in six to eight genome regions and archived OUR serum samples, seven strains were identified with a new and complex 01/B recombinant pattern in common, different from that of CRF15_01B. Complete sequencing of three strains, amplified from serum as overlapping half-genomes, confirmed their common recombinant structure, mostly CRF01_AE, but with segments of subtype B in pol and gp41, plus a region of frequent 01/B crossovers in pol. OUR strains 1969P, 2275P, and 2478P were from individuals without direct epidemiological linkage and thus establish CRF34_01B. More comprehensive HIV-1 prevention and treatment programs in IDU can help to limit the growing complexity of HIV-1 strains in Thailand.
Expression Profiling of Cell Lines Expressing Regulated NF2 Transcripts (2002)

Abstract : Expression profiling is a powerful novel technique to examine changes in the expression of a large number of genes at the same time. Different phenotypic states of a cell can be translated into specific gene expression signatures. As a complement to yeast two hybrid studies we proposed using gene expression profiling to determine changes in gene expression as a function of expression of the neurofbromatosis-2 (NF2) gene in schwannoma cells. The strength of our approach is that we will not use tissues from patients, but will concentrate on cell lines in which NF2 expression can be controlled through the Tet/On system. In this system, treatment of cells with tetracycline (tet) induces expression of a tet-regulated gene, which in turn regulates the expression of the gene of interest. We have now generated several cell lines that express NF2 in a regulated fashion. The parent lines are RT4 schwannoma cells and mouse embryonic fibroblasts. A time course for NF2 expression has been established. A total of four cell lines have been tested on microarrays to detect expression changes. Surprisingly, no changes common to expression of isoform 1 and 2 have been detected so far. In the last year, we have used cell lines that express HRS in the tet system to study expression changes induced by HRS in the presence or absence of EGF. We established a time-course of EGF-induced genes and then examined the effects of long-term treatment (18hrs) with EGF in the presence or absence of exogenous HRS. The results will provide a framework for the interpretation of future gene expression studies in vitro and in NF2 tumors.
Cellular and molecular requirements for the recall of IL-4-producing memory CD4+CD45RO+CD27– T cells during protection induced by attenuated Plasmodium falciparum sporozoites (2002)

The requirements for maintenance of antigen (Ag)-specific memory T cells in protection to malaria is poorly understood. We have previously demonstrated a recall of IL-4-producing memory CD4(+)CD45RO(+) T cells with parasitized red blood cells (pRBC) in persons protected by radiation-attenuated Plasmodium falciparum sporozoites (gamma-spz). Using the CD27 marker, we have now identified two subsets of CD4(+)CD45RO(+) T cells: CD4(+)CD45RO(+)CD27(+) T cells representing an early memory and CD4(+)CD45RO(+)CD27() T cells representing a terminally differentiated memory cells. A small subset of CD4(+)CD45RO(+)CD27(-) T cells also expressed CD70, the CD27 ligand. The addition of anti-CD70 monoclonal antibody (mAb) to pRBC-stimulated cultures significantly inhibited the conversion of CD27(+) to CD27(-) subset without profoundly affecting IL-4 production. In contrast, the inclusion of anti-CD27 mAb in parallel cultures abrogated IL-4 production without interfering with conscription of T cells into the CD27(-) T cell set. We propose that the persistence of memory CD4(+) T cells depends on Ag-driven conscription of a mature memory phenotype through co-ligation of CD27 and CD70 expressed, respectively, on CD27(+) and CD27(-) T cells. Hence, protracted protection in malaria depends in part on memory CD4(+) T cells that require specific Ag presumably from the repositories of liver-and blood-stage antigens and the delivery of a second signal from the CD27:CD70 interaction.