gebhart/patrepeval huggingface dataset:
Co-immunoprecipitation of the Ly-5 molecule and an endogenous protease: a proteolytic system requiring a reducing agent and Ca2+1. (1985)

Sodium [3H]borohydride- and [35S]methionine-labeled Ly-5 molecules from mouse thymocytes and T lymphoma cells were isolated with specific antibody and Staphylococcus aureus Cowan I (SaCI) strain; after extensive washing of the complexes, elution with Laemmli's reducing buffer (0.05 M Tris [pH 6.8 or 6.0], 4% sodium dodecyl sulfate [SDS], and 2% 2-mercaptoethanol [2-ME]) resulted in partial breakdown of the isolated Ly-5 molecules from a Mr = 175,000 to 150,000. Other proteins present during the elution step showed no evidence of proteolysis. 2-ME and SDS were required for proteolysis; although addition of exogenous Ca2+ during elution was not necessary, both EDTA and EGTA inhibited breakdown of the molecule that could be overcome by excess Ca2+. Of a variety of protease inhibitors and thiol-reactive agents tested, only TAME and oxidized glutathione blocked proteolysis almost completely. SaCI, serum, and contaminating antibodies were ruled out as the source of the proteolytic activity. More stringent preclearing and washing conditions did not eliminate endogenous proteolysis of the Ly-5 molecule. The endogenous proteolytic fragment had a Mr distinct from the tryptic fragment of the Ly-5 molecule. We conclude that the Ly-5 molecule may be autolytic or tightly associated with a distinct cellular protease.
Wertigkeit der Imprintzytologie von Kryobiopsien in der Diagnostik endobronchialer Tumore (2009)

Die Kryoextraktion ermöglicht die endobronchiale Entnahme großer Gewebeproben von hoher Qualität. Die histologische Beurteilung der Proben wird durch notwendige Prozessierungsschritte, so dass in der Regel 1–2 Tage vergehen, bis eine Diagnose gestellt werden kann. Im Gegensatz zur Histologie ist die Aufarbeitung zytologischer Präparationen weniger zeitaufwändig. Daher ist die mikroskopische Beurteilung zytologischer Präparate bereits am Entnahmetag möglich. Zusätzlich zur klinischen Bedeutung könnte die Beschleunigung des Diagnoseprozesses zu einer Verkürzung des Klinikaufenthaltes führen.
Catalytic dehydrogenation of ethanol into acetaldehyde and isobutanol using mono- and multicomponent copper catalysts (2017)

The purpose of this work was to investigate biomass-derived ethanol dehydrogenation into acetaldehyde using several mono- and multicomponent (CuO, ZnO and Cr 2 O 3 )-containing catalysts supported on industrial size Al 2 O 3 beads. The catalysts, prepared with either solution combustion or incipient wetness method, were characterized by using various physico-chemical methods, such as EDXA, SEM-EDXA, TEM, XRD, XPS, pyridine adsorption desorption FTIR, and ζ-potential measurements. The results revealed that the multicomponent catalysts exhibited superior activity compared to the metal oxide catalysts containing only one metal oxide. In addition, the most selective catalyst towards acetaldehyde formation, with 50% selectivity at 55% conversion of ethanol at 300 °C and WHSV 1 h −1 was CuO Cr 2 O 3 /Al 2 O 3 prepared by using the solution combustion method, indicating that this inexpensive and rapid catalyst preparation method is promising for other applications.
3D/2D Registration of Mapping Catheter Images for Arrhythmia Interventional Assistance (2009)

Radiofrequency (RF) catheter ablation has transformed treatment for tachyarrhythmias and has become first-line therapy for some tachycardias. The precise localization of the arrhythmogenic site and the positioning of the RF catheter over that site are problematic: they can impair the efficiency of the procedure and are time consuming (several hours). Electroanatomic mapping technologies are available that enable the display of the cardiac chambers and the relative position of ablation lesions. However, these are expensive and use custom-made catheters. The proposed methodology makes use of standard catheters and inexpensive technology in order to create a 3D volume of the heart chamber affected by the arrhythmia. Further, we propose a novel method that uses a priori 3D information of the mapping catheter in order to estimate the 3D locations of multiple electrodes across single view C-arm images. The monoplane algorithm is tested for feasibility on computer simulations and initial canine data.
A Novel KCNJ11 Mutation Associated with Congenital Hyperinsulinism Reduces the Intrinsic Open Probability of β-Cell ATP-sensitive Potassium Channels (2005)

The beta-cell ATP-sensitive potassium (KATP) channel controls insulin secretion by linking glucose metabolism to membrane excitability. Loss of KATP channel function due to mutations in ABCC8 or KCNJ11, genes that encode the sulfonylurea receptor 1 or the inward rectifier Kir6.2 subunit of the channel, is a major cause of congenital hyperinsulinism. Here, we report identification of a novel KCNJ11 mutation associated with the disease that renders a missense mutation, F55L, in the Kir6.2 protein. Mutant channels reconstituted in COS cells exhibited a wild-type-like surface expression level and normal sensitivity to ATP, MgADP, and diazoxide. However, the intrinsic open probability of the mutant channel was greatly reduced, by approximately 10-fold. This low open probability defect could be reversed by application of phosphatidylinositol 4,5-bisphosphates or oleoyl-CoA to the cytoplasmic face of the channel, indicating that reduced channel response to membrane phospholipids and/or long chain acyl-CoAs underlies the low intrinsic open probability in the mutant. Our findings reveal a novel molecular mechanism for loss of KATP channel function and congenital hyperinsulinism and support the importance of phospholipids and/or long chain acyl-CoAs in setting the physiological activity of beta-cell KATP channels. The F55L mutation is located in the slide helix of Kir6.2. Several permanent neonatal diabetes-associated mutations found in the same structure have the opposite effect of increasing intrinsic channel open probability. Our results also highlight the critical role of the Kir6.2 slide helix in determining the intrinsic open probability of KATP channels.
Proportioning criteria for traditional and innovative Extrados techniques for the strenghtening of barrel vaulted structures subjected to rocking of the abutments (2010)

In this paper, the behavior of barrel-vaulted structures undergoing rocking of the abutments and the effectiveness of a few retrofit solutions are discussed. The comprehension of the structural performance of vault-abutment systems is fundamental for their seismic vulnerability assessment, and for the design of efficient strengthening techniques. In the paper, traditional techniques such as extrados thin concrete slab or masonry spandrel walls as well as an innovative solution with an extrados thin improved lime mortar slab reinforced by means of glass fiber mesh are considered. The different strengthening solutions are studied and compared on the basis of the results of non linear numerical analyses and by reference to a simplified analytical approach. Numerical and analytical models are validated through comparison with the results of a recent experimental study focusing on the behavior of vaulted masonry structures subjected to rocking of the abutments. The validated models can be used by engineers for the seismic vulnerability assessment of masonry vaulted structures as well as for the proportioning of possible extrados strengthening solutions, and will be used in the future to explore different structural system configurations.
Unified Compression-Based Acceleration of Edit-Distance Computation (2010)

The edit distance problem is a classical fundamental problem in computer science in general, and in combinatorial pattern matching in particular. The standard dynamic programming solution for this problem computes the edit-distance between a pair of strings of total length O(N) in O(N^2) time. To this date, this quadratic upper-bound has never been substantially improved for general strings. However, there are known techniques for breaking this bound in case the strings are known to compress well under a particular compression scheme. The basic idea is to first compress the strings, and then to compute the edit distance between the compressed strings. As it turns out, practically all known o(N^2) edit-distance algorithms work, in some sense, under the same paradigm described above. It is therefore natural to ask whether there is a single edit-distance algorithm that works for strings which are compressed under any compression scheme. A rephrasing of this question is to ask whether a single algorithm can exploit the compressibility properties of strings under any compression method, even if each string is compressed using a different compression. In this paper we set out to answer this question by using straight line programs. These provide a generic platform for representing many popular compression schemes including the LZ-family, Run-Length Encoding, Byte-Pair Encoding, and dictionary methods. For two strings of total length N having straight-line program representations of total size n, we present an algorithm running in O(nN log(N/n)) time for computing the edit-distance of these two strings under any rational scoring function, and an O(n^{2/3}N^{4/3}) time algorithm for arbitrary scoring functions. Our new result, while providing a signi cant speed up for highly compressible strings, does not surpass the quadratic time bound even in the worst case scenario.
Gas chromatographic method for analysis of chlorpyrifos and endosulfan insecticides in topically treated houseflies (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas chromatographic method for analysis of chlorpyrifos and endosulfan insecticides in topically treated housefliesSolang Uk and Chester M. HimelCite this: J. Agric. Food Chem. 1972, 20, 3, 638–642Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/jf60181a051https://doi.org/10.1021/jf60181a051research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multi-Fingered Haptic Interface Robot Handling Plural Tool Devices (2007)

Tool-type haptic interfaces such as scissors are used to present force feeling for surgical training in virtual reality environment. Presentation of force feelings of plural tools needs to prepare many single tool-type haptic interfaces. This paper proposes newly conceptual idea for plural tool-type haptic interfaces. The proposed system consists of single tool-type haptic devices and a multi-fingered haptic interface. The system has a greater potential for the force feelings of plural tool devices than does a single tool-type interface in the view of work space, removable equipment, force control, small dimensions, and simple tool-type device. Tool-type devices, which are scissors, injector, and knife, are developed to present reactive feeling. Experimental results of cutting simulation are shown to demonstrate the effectiveness of proposed system
Gap waveguide structure in LTCC for millimeter-wave applications (2014)

Gap waveguide technology represents an emerging and interesting solution for the development of circuits and components operating in the millimeter-wave and sub-millimeter-wave region. In this new guiding structure the energy is transmitted through the air gap existing between two parallel metal plates with a HIS boundary condition to assure energy confinement. These conditions are implemented by means of a multiplicity of conducting nails periodically distributed on both sides of the guiding media. This paper presents a new of the Gap Waveguide concept using low temperature co-fired ceramic technology (LTCC) in sub-millimeterwave band. Compared to substrate integrated waveguide (SIW) technology, the first interest is the minimization of dielectric losses due to the propagation in air. Furthermore, it is shown that the technological constraints are less severe than for the conception of SIW waveguide (diameter and periodicity of vias). The concept is illustrated with a gap waveguide example working at around 170 GHz.
Investigation of self-phase modulation based optical regeneration in single mode As2Se3 chalcogenide glass fiber (2005)

We investigate the feasibility of all-optical regeneration based on self-phase modulation in single mode As2Se3 chalcogenide fiber. By combining the chalcogenide fiber with a bandpass filter, we achieve a near step-like power transfer function with no pulse distortion. The device is shown to operate with 5.8 ps duration pulses, thus demonstrating the feasibility of this device operating with high bit-rate data signals. These results are achieved with pulse peak powers <10 W in a fully passive device, including only 2.8 m of chalcogenide fiber. We obtain an excellent agreement between theory and experiment and show that both the high nonlinearity of the chalcogenide glass along with its high normal dispersion near 1550 nm enables a significant device length reduction in comparison with silica-based devices, without compromise on the performance. We find that even for only a few meters of fiber, the large normal dispersion of the chalcogenide glass inhibits spectral oscillations that would appear with self-phase modulation alone. We measure the two photon absorption attenuation coefficient and find that it advantageously affects the device transfer function.
Micro-photoluminescence study of heterostructured GaAs/AlGaAs and GaAs/GaAsSb nanowires grown by molecular beam epitaxy (2008)

Micro-photoluminescence study of heterostructured GaAs/AlGaAs and GaAs/GaAsSb nanowires grown by molecular beam epitaxy
Interaction of Superplasticizers with Clay-Bearing Aggregates (2003)

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Experimental transmission of bovine leukosis virus by simulated rectal palpation (1988)

Eight six-month-old Holstein male calves were experimentally inoculated by rectal palpation with whole blood from a donor seropositive to bovine leukosis virus. The inoculation consisted of the deposition of 2 ml of whole blood on a disposable obstetrical sleeve followed by a 30 second rectal palpation to simulate the process of pregnancy detection or artificial insemination. This procedure was repeated at weekly intervals for three consecutive weeks. All eight calves developed antibodies to bovine leukosis virus within five weeks after the initial palpation. The presence of the virus was demonstrated in the peripheral blood leucocytes of all eight calves at nine weeks. These results indicated that routine rectal palpation may be an effective mode of spread of bovine leukosis virus in susceptible cattle.
ChemInform Abstract: SUBSTITUTIONSRK. VON 3‐PHENYL‐THIOPHEN (1970)

Abstract Die Vilsmeyer‐Formylierung der Titelverbindung (I) ergab ein 94 : 6‐Gemisch der Aldehyde (IIa) und (IIIa).
Catalytic Diastereoselective Petasis Reactions (2011)

Echter Mehrwert: Die erste diastereoselektive Petasis-Reaktion in Gegenwart chiraler Biphenolkatalysatoren ermöglicht die Synthese von syn- und anti-β-Aminoalkoholen in reiner Form. In dieser Mehrkomponentenreaktion kommen Boronate, α-Hydroxyaldehyde und Amine zur Anwendung (siehe Schema). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Filtration - filters and filter media (1977)

This report presents a detailed review of the application and operational aspects of the filtration process and outlines criteria that should be applied for selecting filters and filter media for various system and slurry characteristics. Chapter I classifies filters according to their mode of operation and the driving force employed to effect separation between solid and liquid. They are therefore grouped according to whether used in batch or continuous operation, whether the driving force is gravity, pressure, vacuum, or centrifugal, and according to feeding arrangement and the mechanism of cake removal. Generally, the most suitable filter for a given operation is the one which will fulfill the requirements at minimum overall cost. Since cost is related to filtering area, high rates of filtration are normally provided by high pressures and continuous operation. Maximum pressures, on the other hand, are often limited by mechanical design considerations and batch operation thus may be necessary. The illustrated report provides essential characteristics of the most common types of filters, stating advantages and disadvantages of each. Plate filter presses are the most common batch filters. In continuous filters, filtration, washing, dewatering and cake discharge take place simultaneously. Continuous vacuum filters have wide application, particularly in rotary drum and rotary disc configurations, and are described in detail. Continuous pressure filters are similar in many respects to their vacuum counterparts but are more complex and expensive to build and operate. Factors which determine filter selection include cake formation characteristics, production level, required process results and construction materials. Filter selection is also based on slurry characteristics. Chapter II discusses the various types of material used as filter media. Criteria are presented for making a selection according to application on the basis of physical properties strength, blinding, or cake discharge, chemical properties resistance to chemicals, to heat, etc. and constructional properties types of yarn, fabric geometry, weave pattern, etc. Optimum filter medium choice is a compromise between the maximum service life, recovery, cake release, permeability of flow, production rate, gasketing, resistance to blinding, and clarity of filtrate. Ranking of the numerous types of filter cloth as to suitability for various applications is presented in tabular form.
The tissue–blood partition coefficient of iodoantipyrine in pig brain and its change with age (1983)

The tissue-blood partition coefficient of 125I-labelled iodoantipyrine was measured in pig brain. The mean coefficient for 11 neonatal piglets (aged 0.5 to 4 days) was 0.718 mL/g (SD 0.083). Measurements in a further 11 animals up to 144 days old (at which time pigs are sexually mature), showed that the partition coefficient increased significantly with age, possibly as a result of the accumulation of brain lipid during growth. The change in partition coefficient with age was curvilinear, rising to unity as the animals reached maturity. There were significant differences between the partition coefficients in grey and in white matter, but these were so small relative to the differences between pigs that they could be neglected for all practical purposes. Since the accuracy of measurement of cerebral blood flow (CBF) by the Kety-Schmidt technique depends directly on the partition coefficient of the tracer, it is important to confirm that apparent changes of CBF do not simply reflect alterations in the partition coefficient rather than real changes in blood flow.
A comparison of some physical properties of polyethylene–styrene graft copolymers prepared by the trapped free radical method and polyethylene–polystyrene blends (1960)

Abstract The preparation and properties of polyethylene–styrene graft copolymers using trapped free radicals produced by gamma rays has been reported. When polystyrene branches are attached to the polyethylene chain there is reinforcement of the properties of polyethylene, whereas the corresponding physical blend of polystyrene and polyethylene has lowered physical properties.
A Robust Localization Algorithm for Mobile Sensors Using Belief Functions (2011)

One of the main objectives of localization algorithms is to compute accurate estimates of sensor positions. This task is usually performed using measurements exchanged with neighboring sensors. However, when erroneous measurements occur, the localization process may yield wrong estimates, which leads to unreliable information for location-based applications. This paper proposes a robust localization technique that works efficiently, even under unreliable measurements assumptions. The proposed method uses belief function theory to estimate sensors locations. Assuming that the reliability of sensors measurements is known, the method combines all the available information to make a final decision about the positions. Each measurement is then used to define a belief function based on the reliability information. Experiments with simulated data demonstrate the effectiveness of this approach compared with state-of-the-art methods using different combination rules.
Design of a Circulation Control Stern Plane for Submarine Applications (1971)

This study was undertaken to design a non-deflecting circulation control (CC) submarine stern plane to provide maneuverability control and eliminate the possibility of catastrophic crash dives due to stern plane jamming. Symmetric elliptic sections with tangential blowing out of upper and lower slots over a rounded trailing edge were used because of their high lift and equivalent aerodynamic (hydrodynamic) efficiencies. The CC model stern plane so designed was restricted by the requirement to maintain the same planform as a conventional stern plane, by the existence of a large boundary layer on the main body, and by the additional requirement of zero deflection. With moderate blowing, it was able to meet or exceed the prescribed lifting (maneuvering) requirements for the conventional deflecting control surface. In the event of a blowing failure, inherent stability would result due to the fixed nature of the plane. The study contains a detailed design procedure; supporting experimental data; the final geometry of the blown model stern plane; and a similar study on an alternate blown configuration with end plates.
Conversion of benzene and chlorobenzene into polyhydroxylated cyclohexane derivatives related to cyclophellitol (1995)

Reaction of the dienes 4–6 with diphenylketene gave the [2 + 2]-adducts 7–9 and the [4 + 2]-adducts 10–12, respectively. The [4 + 2]-adduct 10 has been converted into the ester 14 and the tetraol 16; the latter compound is an isomer of cyclophellitol 17.
Two Photon Ionization of Benzene in Methanol and Cyclohexane Solution (1982)

Abstract Irradiation of benzene with 15 ns flashes of 265 nm light caused ionization as evidenced by optical absorption measurements. In the case of dilute methanol solutions solvated electrons were formed. The yield depends on the intensity of the incident light I as ϕ (e s̄olv ) ∝ I 1.8 . In the case of cyclohexane solution dimer radical cations were detected by their absorption between 600 and 1100 nm. O 2 enhances the yield of dimer cations because it scavenges electrons, thus impeding ion recombination.