gebhart/patrepeval huggingface dataset:
Integrated development and maintenance of software products to support efficient updating of customer configurations: a case study in mass market ERP software (2005)

The maintenance of enterprise application software at a customer site is a potentially complex task for software vendors. This complexity can unfortunately result in a significant amount of work and risk. This paper presents a case study of a product software vendor that tries to reduce this complexity by integrating product data management (PDM), software configuration management (SCM), and customer relationship management (CRM) into one system. The case study shows that by combining these management areas in a single software itnowledge base, software maintenance processes can be automated and improved, thereby enabling a software vendor of enterprise software to serve a large number of customers with many different product configurations.
Adiponectin Inhibits Osteoclastogenesis and Bone Resorption via APPL1-mediated Suppression of Akt1 (2011)

Adiponectin is an adipokine playing an important role in regulating energy homeostasis and insulin sensitivity. However, the effect of adiponectin on bone metabolism shows contradictory results according to different research studies. In this study femurs were isolated from genetically double-labeled mBSP9.0Luc/β-ACT-EGFP transgenic mice and were transplanted into adiponectin knock-out mice or wild type mice to investigate the effect of temporary exposure to adiponectin deficiency on bone growth and metabolism. We found that the growth of bone explants in adiponectin knock-out mice was significantly retarded. Histological analysis, microcomputed tomography analysis, and tartrate-resistant acid phosphatase staining revealed reduced trabecular bone volume, decreased cortical bone, and increased osteoclast number in bone explants in adiponectin knock-out mice. We then found that adiponectin inhibits RANKL-induced osteoclastogenesis from RAW264.7 cells and down-regulates RANKL-enhanced expressions of osteoclastogenic regulators including NFAT2, TRAF6, cathepsin K, and tartrate-resistant acid phosphatase. Adiponectin also increases osteoclast apoptosis and decreases survival/proliferation of osteoclast precursor cells. Using siRNA specifically targeting APPL1, the first identified adaptor protein of adiponectin signaling, we found that the inhibitory effect of adiponectin on osteoclasts was induced by APPL1-mediated down-regulation of Akt1 activity. In addition, overexpression of Akt1 successfully reversed adiponectin-induced inhibition in RANKL-stimulated osteoclast differentiation. In conclusion, adiponectin is important in maintaining the balance of energy metabolism, inflammatory responses, and bone formation.
The Need to maintain Intraocular Pressure over 24 Hours (2012)

Glaucoma patients who appear to be stable based on daytime in-clinic intraocular pressure (IOP) measurements may not be fully controlled over each 24-hour period. Given that there is sufficient evidence that IOP fluctuation may impact progression, the aim of management of glaucoma thus, is to achieve a target IOP with minimal diurnal fluctuation. How to cite this article: Bhartiya S, Ichhpujani P. The Need to Maintain Intraocular Pressure over 24 Hours. J Current Glau Prac 2012;6(3):120-123.
Cofactor Engineering for Enhancing the Flux of Metabolic Pathways (2014)

The manufacture of a diverse array of chemicals is now possible with biologically engineered strains, an approach that is greatly facilitated by the emergence of synthetic biology. This is principally achieved through pathway engineering in which enzyme activities are coordinated within a genetically amenable host to generate the product of interest. A great deal of attention is typically given to the quantitative levels of the enzymes with little regard to their overall qualitative states. This highly constrained approach fails to consider other factors that may be necessary for enzyme functionality. In particular, enzymes with physically bound cofactors, otherwise known as holoenzymes, require careful evaluation. Herein, we discuss the importance of cofactors for biocatalytic processes and show with empirical examples why the synthesis and integration of cofactors for the formation of holoenzymes warrant a great deal of attention within the context of pathway engineering.
Combination therapy with anti-PD-1 or PD-1 antibody alone in pediatric patients with relapsed or refractory cancer. (2021)

e22004 Background: There is limited experience of PD-1 combined with other therapies in children. We aimed to explore the antitumor activity and safety of PD-1 antibody monotherapy or combination with other regimens in relapsed or refractory pediatric cancer. Methods: This was an observational retrospective study performed at two academic medical centers (Sun Yat-sen University Cancer Center and Nanfang Hospital, Southern Medical University) The primary objective of this study was to describe the overall response rate (ORR) and disease control rate (DCR). Secondary objectives included characterizing toxicities according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4.03 as well as describing progression free survival (PFS) and overall survival (OS). Results: Of the 22 pediatric cancer patients who received PD-1 inhibitors, the median follow-up for all patients after the commencement of PD-1 therapy with or without other regimens was 12.3 months (0-43 months). The objective response rate (ORR) and disease control rate (DCR) of the 6 patients with HL were 83.3% (3CR and 2PR) and 100%, respectively. No objective response was observed in patients with melanoma or Burkitt lymphoma evaluated in this study. For patients treated with PD-1 inhibitor combination therapy, PD-1 antibody combined with decitabine showed potential efficacy in advanced pediatric cancer patients. One of the Three of patients who received PD-1 combined with decitabine achieved CR and another two other patients achieved PR. At the data cutoff, 10 of the 13 (76.9%) patients achieved disease control as the best objective response. The median PFS and OS were 90 days (95%CI: 10.733-169.267) and 158 days (95%CI: 131.514-184.486) respectively. There were no severe treatment-related adverse events (TRAEs) directly attributed to PD-1 monotherapy. The severe TRAEs are due to chemotherapy in the combination regimen. Conclusions: PD-1 monotherapy demonstrated antitumor activity in a population of pediatric patients with HL. The regimen of PD-1 inhibitor combined with decitabine showed potential in treating with pediatric cancer patients.
BIOLOGICAL ACTIVITY OF STEROIDS AS DETERMINED BY ASSAY OF RENIN-SUBSTRATE (HYPERTENSINOGEN) (1951)

BILATERAL adrenalectomy of normal rats causes a lowering of the level of plasma renin-substrate (hypertensinogen) (Gaudino, 1944). Treatment of such animals with desoxycorticosterone or with 17-hydroxy-11-dehydrocorticosterone restores renin-substrate to normal or near normal. These findings suggest that the assay of renin-substrate in the plasma of adrenalectomized rats before and after the administration of steroids might provide new information concerning the relative biological activity of these compounds. Therefore, experiments were performed with steroids on normal rats and with ACTH on normal and hypophysectomized rats in the hope that additional information could be obtained regarding the mechanism of renin-substrate formation.
Performance Trade-Offs in Using NVRAM Write Buffer for Flash Memory-Based Storage Devices (2009)

While NAND flash memory is used in a variety of end-user devices, it has a few disadvantages, such as asymmetric speed of read and write operations, inability to in-place updates, among others. To overcome these problems, various flash-aware strategies have been suggested in terms of buffer cache, file system, FTL, and others. Also, the recent development of next-generation nonvolatile memory types such as MRAM, FeRAM, and PRAM provide higher commercial value to non-volatile RAM (NVRAM). At today's prices, however, they are not yet cost-effective. In this paper, we suggest the utilization of small-sized, next-generation NVRAM as a write buffer to improve the .overall performance of NAND flash memory-based storage systems. We propose various block-based NVRAM write buffer management policies and evaluate the performance improvement of NAND flash memory-based storage systems under each policy. Also, we propose a novel write buffer-aware flash translation layer algorithm, optimistic FTL, which is designed to harmonize well with NVRAM write buffers. Simulation results show that the proposed buffer management policies outperform the traditional page-based LRU algorithm and the proposed optimistic FTL outperforms previous log block-based FTL algorithms, such as BAST and FAST.
Does Online Search Crowd Out Traditional Search and Improve Matching Efficiency? Evidence from Craigslist (2014)

Since the seminal work of Stigler in 1962, economists have recognized that information is costly to acquire and leads to “search frictions.” Growth in online search has lowered the cost of information acquisition. We analyze the expansion of the website Craigslist, which allows users to post job and housing ads. Exploiting the sharp geographic and temporal variation in the availability of online search induced by Craigslist, we produce three key findings: Craigslist significantly lowered classified job advertisements in newspapers, caused a significant reduction in the apartment and house rental vacancy rate, and had no effect on the unemployment rate.
The Relationship Between Gelatinase A Activity in Aqueous Humor and Glaucoma (1999)

The development of POAG may be associated with the abnormal expression of gelatinase A in aqueous humor.
Preparation of enantiomerically pure phosphine oxides by nucleophilic displacement chemistry using oxazaphospholidines (1993)

The synthesis of enantiomerically pure triaryl- and diarylvinyl-phosphine oxides from PCl3 by three sequential nucleophilic displacements at phosphorus is demonstrated. A single diastereoisomer of the P-chlorooxazaphospholidine 4 is treated with an arylmagnesium halide to effect displacement of chloride. The major stereoisomer is formed with retention of configuration. After oxidation to the phosphine oxide with tert-butyl hydroperoxide, a second Grignard reaction leads to regiospecific and stereospecific P–O ring cleavage so that a second aryl group is introduced with retention of configuration. For the final step, the P–N bond is subjected to acid-catalysed methanolysis, previously shown to occur with inversion of configuration, followed by P–OMe displacement with a third arylmagnesium halide. The overall yield of triarylphosphine oxide is up to 29% for the cited five steps. Simple methoxyaryl or 2-naphthyl residues are employed to demonstrate the methodology, which permits the multigram-scale preparation of this class of compound in 94% e.e. The stereochemical course of the nucleophilic displacements with arylmagnesium halides is consistent with a model in which the organomagnesium reagent is complexed to the oxo-group and attacks phosphorus cis-to it in a direction defined by both electronic and steric factors.
Studies in Polyphosphoric Acid Cyclizations (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies in Polyphosphoric Acid CyclizationsJohn KooCite this: J. Am. Chem. Soc. 1953, 75, 8, 1891–1895Publication Date (Print):April 1, 1953Publication History Published online1 May 2002Published inissue 1 April 1953https://pubs.acs.org/doi/10.1021/ja01104a034https://doi.org/10.1021/ja01104a034research-articleACS PublicationsRequest reuse permissionsArticle Views1502Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Construction of the recombinant vaccine based on T-cell epitope encoding Der p1 and evaluation on its specific immunotherapy efficacy. (2015)

Specific immunotherapy (SIT) is currently recognized as the only etiological therapy to ameliorate asthmatic symptom. The current study was aimed at evaluating the immune effect of vaccine MAT3T designed on MHCII pathway, which includes T cell fusion peptide encoding Dermatophagoides pteronyssinus class 1 allergen (Der p1). We initially cloned the nucleotide sequences of TAT, IhC and 3 segments of T cell epitope coding for Der p1, and reassembled these sequences in linear manner to form fusion gene named MAT3T, which was applied to immunize the asthmatic models of mice induced by Der p1 allergen for tentative SIT. ELISA results showed that MAT3T was able to increase the level of IFN-γ in BALF and allergen specific antibody IgG2a in serum, while decrease the level of IL-13 in BALF and allergen specific antibody IgE and IgG1. Pathological confirmation further revealed that the inflammatory reactions and inflammatory cell infiltration were totally reduced in lung tissue of mice after MAT3T treatment. Our results show that the recombinant allergen MAT3T can effectively correct the imbalance of Th1/Th2, and MAT3T may be used as candidate vaccine against asthma on SIT basis.
A Wide-Input-Range Efficiency-Enhanced Synchronous Integrated LED Driver With Adaptive Resonant Timing Control (2016)

A wide-input-range DC-DC-based dimmable LED driver is presented in this paper. The proposed LED driver can be automatically configured to operate in the soft-switching mode under the high-voltage condition in order to minimize the converter's dominant switching power loss. Adaptive resonant timing control is developed to enable proper dead-time generation for on-chip high-voltage power FETs in both hard- and soft-switching modes under different input and output voltages for the power loss minimization. In the proposed LED driver, two low-power body-diode-based zero-voltage detectors and an adaptive resonant timing emulator are also proposed for providing accurate and high-speed zero-voltage switching (ZVS) detection of both power FETs, and achieving optimal quasi-ZVS condition, respectively. Implemented in a 0.5 μm HV CMOS process, the proposed buck-based LED driver can support an input voltage range from 5 V to 115 V and up to 25 series-connected highbrightness LEDs with the maximum output power of 25 W. The LED driver can operate up to 1.6 MHz in the soft-switching mode and 2.2 MHz in the hard-switching mode for providing the peak power efficiencies of 94.4% and 93.6%, respectively. Compared with the state-of-the-art counterparts, this work is the only integrated DC-DC-based dimmable LED driver to demonstrate auto-configurable hard- and soft-switching capability achieving high power efficiency and current accuracy over the widest input voltage range and the largest number of series-connected output LEDs.
Epinephrine-induced lactic acidosis following cardiopulmonary bypass (1997)

The use of epinephrine after cardiopulmonary bypass precipitates the development of lactic acidosis in some patients. This phenomenon is presumably a beta-mediated effect, and is associated with an increase in whole-body and lower limb blood flow and a decrease in whole-body and transfemoral oxygen extraction. The phenomenon does not appear to be related to reduced tissue perfusion and does not have the poor outlook of lactic acidosis associated with shock.
The in vitro and in vivo cytotoxicity of menadione (vitamin K3) against rat transplantable hepatoma induced by 3'-methyl-4-dimethyl-aminoazobenzene. (1991)

Menadione (vitamin K3, 2-methyl-1,4-naphthoquinone) is a synthetic derivative of napthoquinone. Its ability to inhibit cell growth in a wide variety of and human tumor cell types, and in rat hepatocytes has been recognized. Using a rat transplantable hepatoma model, we have evaluated the cytotoxic activity of menadione in hepatoma cells. Tumor cells in culture were sensitive to menadione treatment. The ID50 of drug is 3.4 microM as shown by a colorimetric MTT (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Tumor-bearing rats were randomized into the treatment (n = 16) and control (n = 15) groups. Rats in the treatment group received intraperitoneal injection of menadione (10 mg/2 ml) once a week for four times; the control group received 2 ml water instead. None of the control rats survived after the 17th day following the start of treatment, while 5 out of the 16 treated rats responded well and survived long-term (greater than 60 days). Medadione was shown to inhibit actively the growth of hepatoma cells in vitro as well as in vivo.
Quasi sinusoid commutation for BLDC motor &#x2014; A simplified approach on 16 bit microcontroller platform (2012)

Brushless DC (BLDC) motors are increasingly demanded in various industrial and aerospace control applications. The conventional methods of implementing commutation for the BLDC motors are the Trapezoidal and Sinusoidal Commutation. Trapezoidal Commutation although has the inherent advantage of simpler implementation and lower switching losses, has the disadvantage of increased torque ripple. Sinusoidal Commutation on the other hand offers theoretically zero torque ripples, however has increased switching loss and implementation complexity. The paper proposes the Quasi sinusoid commutation scheme which combines the advantages of both Trapezoidal and Sinusoidal commutation. The proposed commutation offers the advantage of reduced switching loss, reduced torque ripple and does not require complex implementation. A comparative analysis based on simulation of the Trapezoidal, Sinusoidal and Quasi Sinusoid commutation is presented. Trapezoidal commutation and Quasi Sinusoid commutation schemes are implemented on a 24HJ128GP310 PIC microcontroller platform and the experimental results are presented.
DEVELOPMENT OF REGRESSION MODELS TO CONTROL PRODUCT YIELDS AND PROPERTIES OF THE FLUID CATALYTIC CRACKING PROCESS (1999)

ABSTRACT Regression models for predicting product yields and properties for the Fluid Catalytic Cracking (FCC) process are presented. The feedstock properties are used as the primary correlation parameters. The models are based on data collected from various sources from the literature on pilot and commercial plants. The predictions of these models are compared to previous models and also to real data. The proposed models give consistently good predictions. These models can be used to evaluate different feeds to the FCC process and can also be integrated within general refinery mathematical programming (e.g. LP) software for planning and scheduling purposes.
Phase noise and frequency offset compensation in high frequency MIMO-OFDM system (2015)

In this paper, we propose a low complexity two stage estimation and compensation scheme for the MIMO-OFDM system, where both the transmit and receive antennas will encounter different phase noise (PHN) and carrier frequency offset (CFO). Specifically, in the first stage, a simple least squares (LS) estimation is proposed to estimated the corrupt channel realizations. In the second stage, based on the corrupt imperfect channel, a low complexity LS estimation algorithm is proposed to estimate the compensate the effective PHN and CFO. The complexity of the algorithm is comparable with that of the traditional zero-forcing/MMSE algorithm in MIMO system. The solution does not require explicit knowledge of the PHN model and hence, is very robust to model variations. Finally, we show by simulations that there is significant performance gain compared with various existing baseline schemes.
Design and Analysis of Cross-Over Trials (1989)

Completely revised and updated, the second edition of this classic text retains its predecessor's careful balance of theory and practice while incorporating new approaches, more data sets, and a broader scope. Enhancements in this edition include a new chapter on bioequivalence, methods for analyzing longitudinal continuous and categorical data, ex
Nitrate and organic N analyses with second-derivative spectroscopy (1992)

Simple and reliable procedures have been developed for analyses of NO3−, total N, and organic N in freshwaters. NO3− is determined by second-derivative UV spectroscopy. Total N and organic N are determined based on second-derivative analyses of NO3− following persulfate digestion. Resolution of organic N determinations was increased by using ion-exchange resins to remove NO3− from samples with high concentrations of NO3− prior to persulfate oxidation of the organic N.
Modulation of Pentagastrin-Induced Histamine Release by Histamine H<sub>3</sub>Receptors in the Dog (1996)

The histamine H3 receptor mediates a negative feedback control of pentagastrin-induced release of gastric histamine. It is tonically activated by endogenous histamine after pentagastrin in low dosage. The control of acid secretion by the H3 receptor seems to involve modulation of endogenous histamine release, possibly by means of enterochromaffin-like cells.
Obstacle avoidance using flow field divergence (1989)

The use of certain measures of flow field divergence is investigated as a qualitative cue for obstacle avoidance during visual navigation. It is shown that a quantity termed the directional divergence of the 2-D motion field can be used as a reliable indicator of the presence of obstacles in the visual field of an observer undergoing generalized rotational and translational motion. The necessary measurements can be robustly obtained from real image sequences. Experimental results are presented showing that the system responds as expected to divergence in real-world image sequences, and the use of the system to navigate between obstacles is demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>