gebhart/patrepeval huggingface dataset:
Chiral discrimination in electronic energy-transfer processes between dissymmetric metal complexes in solution. Time-resolved chiroptical luminescence measurements of enantioselective excited-state quenching kinetics (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChiral discrimination in electronic energy-transfer processes between dissymmetric metal complexes in solution. Time-resolved chiroptical luminescence measurements of enantioselective excited-state quenching kineticsDavid H. Metcalf, Seth W. Snyder, J. N. Demas, and F. S. RichardsonCite this: J. Am. Chem. Soc. 1990, 112, 15, 5681–5695Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/ja00171a001https://doi.org/10.1021/ja00171a001research-articleACS PublicationsRequest reuse permissionsArticle Views389Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MediPic: Support for Medication Management (2001)

This paper describes the initial design of a device to support the management of medication in a community care environment. From requirements identified through ethnographic study, the proposed medication manager offers an interface that reduces confusion for the residents of the care facility whilst also supporting the learning of self-management skills required for independent living. The prototype also senses actions of the users in order to promote an awareness between residents and staff.
Transport of recycled deuterium to the plasma core in the Tokamak Fusion Test Reactor (1998)

Fueling of the plasma core by recycling in the Tokamak Fusion Test Reactor [Phys. Plasmas 2, 2176 (1995)] has been studied. In plasmas fueled by deuterium recycled from the limiter and tritium-only neutral beam injection, the DT neutron rate provides a measure of the deuterium influx into the core plasma. A reduced influx with plasmas using lithium pellet conditioning and with plasmas of reduced major (and minor) radius is found. Modeling with the DEGAS [D. P. Stotler et al., Phys. Plasmas 3, 4084 (1996)] neutrals code shows that the dependence on radius can be related to the penetration of neutrals through the scrape-off layer.
Faculty Opinions recommendation of Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease. (2008)

Neural stem cells (NSCs) are widely endorsed as a cell source for replacement strategies in neurodegenerative disease. However, their usefulness is currently limited by the inability to induce specific neurotransmitter phenotypes in these cells. In order to direct dopaminergic neuronal fate, we overexpressed Pitx3 in NSCs that were then exposed to E11 developing ventral mesencephalon (VM) in explant culture. This resulted in a significant potentiation of dopaminergic differentiation of the cells. When transplanted into the 6-hydroxydopamine lesioned Parkinsonian rats, these cografts of VM and Pitx3 overexpressing NSCs resulted in a significant restitution of motor function. In addition, there were greater numbers of Girk2 positive A9 neurons in the periphery of the transplants that were NSC derived. This demonstrates that given the correct signals, NSCs can be induced to become dopaminergic neurons that can differentiate into the correct nigrastriatal phenotype required for the treatment of Parkinson's disease. PMID: 18202103
Subtractive Etching of Cu at Low Temperature in Hydrogen-Based Plasmas (2012)

Thin film patterning in integrated circuit processing has traditionally been performed by subtractive processes. However, over the past 25 years, the inability to plasma etch copper (Cu) interconnect patterns has led to patterning of Cu by an additive process: the damascene approach. In the current work, a simple subtractive, low temperature hydrogen (H2) plasma etch process is described that permits an alternative method to damascene technology. Cu thin films were etched in an H2 plasma using inductively coupled plasma (ICP) reactors at temperatures between -150 oC and +100 oC. This process achieves anisotropic Cu features (~82o) with a pure H2 etch rate of ~13 nm/min. Both physical (ion bombardment) and chemical contributions (neutral species) are critical to the Cu etch process.
The Estimation of SEAT Values from Transmissibility Data (2001)

<div class="htmlview paragraph">Seat Effective Amplitude Transmissibility (SEAT) values can be obtained from direct measurements at seat track and top or estimated from transmissibility data and seat track input. Vertical transmissibility was measured for sixteen seats and six subjects on the Ford Vehicle Vibration Simulator, and these 96 functions used to estimate the seat top response for rough road input. SEAT values were calculated, and good correlation to values computed from direct seat top measurements obtained (R<sup>2</sup> of 0.86). Averaging transmissibilities and direct seat measurements over the 6 subjects to obtain correlations for the 16 seats improved R<sup>2</sup> to 0.94, validating this approach.</div>
Morphological transitions in liquid crystal nanodroplets (2012)

A continuum theory is used to study ordering in liquid crystal nanodroplets. The free energy functional that describes the system is minimized using an Euler–Lagrange approach and an unsymmetric radial basis function method. The equilibrium morphology in nanodroplets is shown to represent a delicate balance between bulk and surface contributions; when the radius of the droplet reaches a critical value, that balance is altered and the droplet undergoes a transition. By controlling the anchoring conditions at the droplet's surface, one can control the radius where the transition occurs and even prepare metastable droplets where small perturbations can trigger a morphological transition. The results of the theory are shown to be consistent with recent experimental observations on monodisperse nematic liquid crystal nanodroplets.
Training Maintenance Troops: A Study of Factors Affecting Airman Performance in a Learning Environment (2009)

Sperm function is essential for fertilization and embryogenesis yet semen contain a heterogeneous population of sperm. This study was designed to evaluate two different sperm populations separated by the density gradient method. Semen from 25 idiopathic normozoospermic infertile men was processed by double density gradient centrifugation and evaluated for sperm present in the 50% (upper) layer and the 90% (lower) layer for reactive oxygen species (ROS), sperm chromatin integrity, and morphology. The population of sperm in the 90% layer showed significantly lower ROS levels (22.90 (0.92, 85.32) vs. 382.03 (158.30, 1409.51) and lower DNA fragmentation index (DFI) (24.26 (22.54, 25.50) vs. 29.93 (28.48, 31.25) and higher number of sperm with normal morphology (55 (45.0, 60.0) vs. 32.5 (20, 40) compared to sperm in the 50% layer. However, in the original raw semen, sperm DFI (27.02 (26.19, 27.76)) and percentage high DNA stainability (% HDS) (3.1 (2.40, 3.78)) cells were significantly higher compared to the 90% layer population. Density gradient separation of the sperm subpopulation from the original semen favors the selection of sperm with genome integrity, low levels of ROS, and normal morphology. Therefore presence of pathological sperm in the semen may disrupt the function of normal spermatozoa, and hence the selection of the normal sperm subpopulation may be a better candidate for assisted conception. Further studies are required to evaluate the gradient separated sperm population in assisted reproductive techniques (ART).
STEREOCHEMICAL STUDIES IN THE MORPHINE SERIES. THE RELATIVE CONFIGURATION AT CARBONS FIVE AND SIX (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSTEREOCHEMICAL STUDIES IN THE MORPHINE SERIES. THE RELATIVE CONFIGURATION AT CARBONS FIVE AND SIXHENRY RAPOPORT and GEORGE B. PAYNECite this: J. Org. Chem. 1950, 15, 5, 1093–1102Publication Date (Print):September 1, 1950Publication History Published online1 May 2002Published inissue 1 September 1950https://pubs.acs.org/doi/10.1021/jo01151a028https://doi.org/10.1021/jo01151a028research-articleACS PublicationsRequest reuse permissionsArticle Views122Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Micropore growth model for endothermic gasification reactions under reaction control (1985)

In most microscopic type gas-solid reaction models, the micropore length is assumed to be constant and the gasification is assumed to enlarge the radius of the micropores. Several sets of published pore size distribution data on carbon activation were analyzed on the basis of the pore system in which micropores are assumed to be growing uniformly on the surface of spherical macropores. Mesopores are assumed to provide the connection among macropores. The analysis showed that micropore length did reach steady state within a short period of reaction time, and it then remained constant even after 85% of the carbon had been gasified. Furthermore, the gasification temperature is the major factor controlling the steady state micropore length.
Extracting Sense-Disambiguated Example Sentences From Parallel Corpora (2009)

Example sentences provide an intuitive means of grasping the meaning of a word, and are frequently used to complement conventional word definitions. When a word has multiple meanings, it is useful to have example sentences for specific senses (and hence definitions) of that word rather than indiscriminately lumping all of them together. In this paper, we investigate to what extent such sense-specific example sentences can be extracted from parallel corpora using lexical knowledge bases for multiple languages as a sense index. We use word sense disambiguation heuristics and a cross-lingual measure of semantic similarity to link example sentences to specific word senses. From the sentences found for a given sense, an algorithm then selects a smaller subset that can be presented to end users, taking into account both representativeness and diversity. Preliminary results show that a precision of around 80 % can be obtained for a reasonable number of word senses, and that the subset selection yields convincing results.
Feasibility and efficacy of knee extension training using a single-joint hybrid assistive limb, versus conventional rehabilitation during the early postoperative period after total knee arthroplasty (2021)

<b>Objectives:</b> To evaluate the feasibility and efficacy of treatment for the recovery of knee joint function after total knee arthroplasty (TKA) using a robotic suit. <b>Patients and Methods:</b> Knee joint extension exercise sessions were started with a robotic suit (single-joint hybrid assistive limb [HAL-SJ, Cyberdyne, Inc., Tsukuba, Japan]) in one group of patients after TKA. Patients who underwent standard rehabilitation were enrolled in the control group. To evaluate feasibility and safety, we assessed the adverse events, the number of training sessions, and training time. We compared the changes in knee joint pain and extension lag (°) between the groups. <b>Results:</b> The average age was 71.3 ± 6.2 years in the HAL-SJ group and 74.9 ± 8.7 years in the control group. There were no severe adverse events. In the HAL-SJ group, training was performed 2.9 times, on average, and lasted 18.8 min. In the HAL-SJ group, there was a reduction in the visual analog scale (VAS) for pain after training, which was not significant. In the control group, the VAS score worsened after the sessions. The extension lag significantly improved in the HAL-SJ group after the 2nd and 3rd sessions, and this was more due to improvements in their active extension range of motion than their passive extension range of motion. <b>Conclusions:</b> HAL-SJ-based training is safe and effective, and leads to instantaneous improvement of extension lag, without worsening knee joint pain. HAL-SJ-based knee extension training could represent a viable novel post-TKA rehabilitation modality.
Increased platelet aggregation <i>in vivo</i> in the Zucker Diabetic Fatty rat: differences from the streptozotocin diabetic rat (2006)

The platelet aggregation results obtained in vitro do not reflect those in vivo, therefore in vitro aggregation data should be interpreted with caution. Moreover, both in vitro and in vivo, different diabetic models exhibit important differences in platelet responsiveness.
<title>Measurement tool of one-way characteristics based on network tomography</title> (2002)

The recent evolution on the network tomography have successfully provided principles and methodologies of inferring network-internal (local) characteristics from only end-to-end measurements, which should be followed by deployment in practical use. In this paper, we propose two types of user-oriented tools for inferring one-way packet losses on paths from/to an user-host (a client) to/from a specified target host (a server or router) without any measurement on the target, which utilize a method based on the network tomography. One is a stand-alone tool running on the client, and the other is a client-server style tool running on both the client and proxy measurement server(s) distributed in the Internet. Both of them can infer one-way packet loss rates not only on a path between the client and an application server, but on a path segment (a portion of the path) between the client and any router residing in the path, and thus can find the congested area along the path. We have developed prototypes of the tools and have evaluated them in experiments in the Internet environment, which showed that the tools could infer one-way packet loss rates within 1% errors in various network conditions.
Experimental and computational investigations of C–H activation of cyclohexane by ozone in liquid CO<sub>2</sub> (2020)

Cyclohexane ozonation in liquid CO<sub>2</sub> produces cyclohexanone, a precursor to adipic acid, cleanly at high yields compared to conventional process.
Intermolecular crosslinking and stereospecific molecular packing in type I collagen fibrils of the periodontal ligament (1986)

A trypsin digest of denatured NaB3H4-reduced native bovine periodontal ligament was prepared and fractionated by gel filtration and cellulose ion-exchange column chromatography. Prior to trypsin digestion, a complete acid hydrolysate was subjected to analyses for nonreducible stable and reducible intermolecular cross-links. Minute amounts of the former and significant amounts of the reduced cross-links dihydroxylysinonorleucine (1.1 mol/mol of collagen), hydroxylysinonorleucine (0.9 mol/mol of collagen), and histidinohydroxymerodesmosine (0.6 mol/mol of collagen) were found. The covalent intermolecular cross-linked two-chained peptides that were isolated were subjected to amino acid and sequence analyses. The structures for the different two-chained linked peptides were alpha 1CB4-5(76-90)[Hyl-87] X alpha 1CB6-(993-22c)[Lysald-16c], alpha 1CB4-5(76-90)[Hyl-87] X alpha 1CB6(993-22c)[Hylald-16c], alpha 2CB4(76-90)[Hyl-87] X alpha 1CB6(993-22c)[Lysald-16c], and alpha 2CB4(76-90)[Hyl-87] X alpha 1CB6(993-22c)[Hylald-16c]. The cross-link in each peptide was glycosylated. This is the first characterization by sequence analysis of a cross-link involving Hyl-87 in an alpha 2 chain in collagen. A stoichiometric conversion of residue 16c aldehyde to an intermolecular cross-link in each of the COOH-terminal nonhelical peptide regions of both alpha 1 chains in a molecule of type I collagen was found. The ratio of alpha 1 to alpha 2 intermolecularly cross-linked chains involved was 3.3:1, indicating a stereospecific three-dimensional molecular packing of type I collagen molecules in bovine periodontal ligament.
Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A<sub>4 </sub>hydrolase (1997)

An aminopeptidase B (Ap-B) was previously purified to homogeneity from rat testis extracts and characterized. In the present work, by using oligonucleotides selected on the basis of partial amino acid microsequences of pure Ap-B and PCR techniques, the nucleotide sequence of a 2.2-kb cDNA was obtained. The deduced amino acid sequence corresponds to a 648-residue protein (72.3 kDa) containing the canonical "HEXXHX18E" signature, which allowed its classification as a member of the M1 family of metallopeptidases. It exhibits 33% identity and 48% similarity with leukotriene-A4 hydrolase, a relation further supported by the capacity of Ap-B to hydrolyze leukotriene A4. Both enzymes also were closely related to a partially sequenced protein from Dictyostelium discoideum, which might constitute the putative common ancestor of either aminopeptidase or epoxide hydrolase, or both. Ap-B and its mRNA were detected in the germ line and in the Sertoli and peritubular cells of the seminiferous tubules. Because the enzyme was found in the medium conditioned by spermatocytes and spermatids and in the acrosome during spermatozoa formation, together these observations suggested an involvement of this exometallopeptidase in the secretory pathway. It is concluded that this ubiquitous enzyme may be involved in multiple processing mechanisms.
Changes in Parahippocampal White Matter Integrity in Amnestic Mild Cognitive Impairment: A Diffusion Tensor Imaging Study (2009)

In the present study, changes in the parahippocampal white matter (PWM), in the region that includes the perforant path, were investigated, in vivo, in 14 individuals with amnestic mild cognitive impairment (aMCI) compared to 14 elderly controls with no cognitive impairment (NCI). For this purpose, (1) volumetry; (2) diffusion tensor imaging (DTI) derived measures of mean diffusivity (MD) and fractional anisotropy (FA); and (3) tractography were used. In addition, regression models were utilized to examine the association of PWM measurements with memory decline. The results from this study confirm previous findings in our laboratory and others, showing that compared to controls, individuals with aMCI have PWM volume loss. In addition to volume reduction, participants with aMCI demonstrated a significant increase in MD, but no difference in FA, both in the PWM region and in fibers modeled to pass through the PWM region. Further, the DTI metric of MD was associated with declarative memory performance, suggesting it may be a sensitive marker for memory dysfunction. These results indicate that there is general tissue loss and degradation (decreased volume; increased MD) in individuals with aMCI compared to older people with normal cognitive function. However, the microstructural organization of remaining fibers, as determined by measures of anisotropic diffusion, is not significantly different from that of controls.
New experimental results supporting the hypothesis of the excitation of collective modes in the 40Ca + 40Ca reaction (1979)

Steps in the γ-ray multiplicity as function of the excitation energy have been observed in coincidence with the incompletely relaxed part of the energy spectra of fragments emitted in the reaction 40Ca + 40Ca at 400 MeV. Excitation energies and angular dependence of these variations suggest that they are correlated with the excitation of high energy collective modes through a rather direct process in the early stages of the reaction. l-values of this excitation mode are discussed.
Microstructure and Isothermal Oxidation Resistance of Thermal Barrier Coatings Deposited by LPPS, CVD and PS-PVD Methods on Inconel 617 Nickel Superalloy (2015)

The paper presents results of research into thermal barrier coatings characterized by higher oxidation resistance. Bondcoats were formed by overaluminizing of the MeCrAlY coating, deposited by low pressure plasma spraying (LPPS). The outer ceramic layer of yttrium oxide stabilized zirconia oxide was deposited by plasma spray physical vapour deposition (PS-PVD). For comparison purposes additionally formed were MeCrAlY bondcoats, which were not subsequently aluminized. The research showed that during CVD overaluminizing there was formed an additional layer built of the β-NiAl phase, which protects the base material from oxidation. Preserved below it increased chromium content ensures resistance to hot corrosion. The outer layer was characterized by columnar structure, similar to that obtained in the EB-PVD process. The isothermal oxidation tests showed that thickness of the TGO layer into overaluminized bondcoat significantly thicker in comparison with conventional LPPS-sprayed MeCrAlY bondcoats.
Programmed self-assembly of peptide–major histocompatibility complex for antigen-specific immune modulation (2018)

A technology to prime desired populations of T cells in the body-particularly those that possess low avidity against target antigen-would pave the way for the design of new types of vaccination for intractable infectious diseases or cancer. Here, we report such a technology based on positive feedback-driven, programmed self-assembly of peptide-major histocompatibility complex (pMHC) directly on the membrane of cognate T cells. Our design capitalizes on the unique features of the protein annexin V (ANXA5), which-in a concerted and synergistic manner-couples the early onset of TCR signaling by cognate pMHC with a surge in pMHC-TCR affinity, with repeated pMHC encounters, and with widespread TCR cross-linking. In our system, ANXA5 is linked to pMHC and firmly engages the plasma membrane of cognate T cells upon (and only upon) the early onset of TCR signaling. ANXA5, in turn, exerts a mechanical force that stabilizes interactions at the TCR-pMHC interface and facilitates repeated, serial pMHC encounters. Furthermore, ANXA5 quickly arranges into uniform 2D matrices, thereby prompting TCR cross-linking. Fusion of ANXA5 to pMHC augments lymphocyte activation by several orders of magnitude (>1,000-fold), bypasses the need for costimulation, and breaks tolerance against a model self-antigen in vivo. Our study opens the door to the application of synthetic, feedback-driven self-assembly platforms in immune modulation.