gebhart/patrepeval huggingface dataset:
ContextawarenessinI-centric systems - DynamicContext Learning Using aRule-Based Approach - (2005)

Capturing contextual information, especially higherlevel contexts, enables systems tounderstand and predict thebehaviour ofamobile user. Thiskindof information ismostly implicit, abstracting a complex state ofasituation, andcanonly partly becaptured by sensors. Higher-level context hasthepotential tomake userapplications simpler andmoreintuitive. However, composing higher-level contexts fromexplicit, atomic contexts requires complex procedures tobeusedand uncertaintv duetoinconsistent sensorreadings and incomplete information tobereduced. Inthis paper, we introduce a newapproach thatassists application developers totakehigher-level contexts intoaccount without theneedtoknowthedetails ofatomic contexts. Todemonstrate ourapproach, wewill introduce the Context-Aware E-Pad(CAEP) wehavedesigned and implemented.
Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the <i>Drosophila</i> eye (2005)

Nicastrin is a component of the Notch signaling pathway involved in proteolytic release of the Notch receptor intracellular domain. It has been postulated that intracellular Notch is required within the nucleus of fly eye progenitor cells to enhance (pro-neural enhancement) and then repress (lateral inhibition) transcription of pro-neural genes. We present here an analysis of Nicastrin function during eye development and find that Nicastrin is essential to early photoreceptor neuron development. Nicastrin mutant tissue displays neuronal loss or hyperplasia; these phenotypes can be rescued by targeted expression of an intracellular form of Notch. Thus, nuclear translocation of Notch and its direct regulation of gene expression appear to be critical to pro-neural enhancement as well as lateral inhibition. In addition, we show that Nicastrin as well as Notch are required to maintain normal R-cell morphology, because the nuclei of mutant photoreceptor neurons cannot maintain their proper position. Thus, Notch signaling plays a role, not only in cell fate specification, but also in differentiation of photoreceptor neurons.
Ex Vivo Study of Transepithelial Corneal Cross-linking (2017)

Corneas treated by transepithelial CXL with an extended pretreatment time of 60 minutes and penetration enhancers exhibited similar characteristics as corneas treated by the deepithelialized CXL approach. By confocal imaging, the transepithelial approach with extended pretreatment time demonstrated evidence of epithelial damage, which may have improved the treatment effect of this group. [J Refract Surg. 2017;33(3):171-177.].
Zur Kenntnis des 7.8‐Dioxy‐chinolis und seiner Abkömmlinge (1952)

Abstract Es wird die Synthese von 2‐Amino‐vanillin und seinen Abkömmlingen beschrieben sowie deren Bereitschaft untersucht, sich mit folgenden Reaktionspartnern zu 7.8‐Dioxy‐chinolinen umzusetzen: einfachen Ketonen, 1.2‐Diketionen, 1.3‐Diketonen, 1.4‐Diketonen, α‐Ketocarbonsäuren, β‐Ketosäureestern, carbo‐u. heterocyclischen Ketonen.
The Synthesis of a Dopamine D<sub>2</sub> Partial Agonist for the Treatment of Schizophrenia (2009)

The synthesis of the phosphoric acid salt of dopamine D2 partial agonist 2-{4-[4-(7-fluoro-naphthalen-1-yl)-piperazin-1-yl]-butoxy}-5,6,7,9-tetrahydro-1,7,9-triaza-benzocyclohepten-8-one (1) is reported. The most prominent feature of the molecule is a seven-membered ring urea functionality that has been prepared via an efficient one-pot, three-step transformation. The original synthesis from the Medicinal Chemistry group provided precursor 13 in 10 steps and 2% overall yield, required four chromatographies and employed unsafe reagents such as 2-iodoxybenzoic acid (IBX) and HClO4. The optimized synthetic route for the preparation of phosphate salt 1 consists of 12 linear steps with a 10% overall yield. Safer and more robust reaction conditions have been developed with only one required chromatography. Another key step in the synthesis is the coupling of iodide 25 with naphthalenopiperazine 12 to provide 13. Due to the difficulty to purify this intermediate, a protocol had to be developed to obtain crude material with the required purity, suitable for use in the subsequent salt formation step. Finally, considerable work was carried out to determine the most stable polymorph of the API. As a result, a robust set of conditions has been developed for the formation of phosphoric acid salt 1, providing the desired polymorph in excellent yield and purity.
Detection of Enterobacterial Lipopolysaccharides and Experimental Endotoxemia by Means of an Immunolimulus Assay Using Both SerotypeSpecific and Cross-Reactive Antibodies (1993)

The immunolimulus (IML) assay system uses solid-phase endotoxin antibodies to capture lipopolysaccharide (LPS), which is then quantified by a modification of the chromogenic limulus amebocyte lysate (CLAL) method. Monoclonal antibodies (MAbs) reactive with selected O antigen serotypes of Escherichia coli (O18) and Salmonella typhimurium (O9, 12), when used in the IML, were shown to be highly specific in detecting their respective endotoxins in purified form and in plasma samples from experimentally infected animals. A murine MAb that was broadly cross-reactive with E. coli, Salmonella, and Shigella endotoxins also proved to be highly effective in the IML assay for capturing LPS molecules from both E. coli and S. typhimurium strains. These results indicate that IML assays can detect smooth-type enterobacterial endotoxins in plasma and suggest that such assays have potential for use in the rapid diagnosis of sepsis and endotoxemia caused by different enterobacterial species.
Synthesis and Reactivity of Side‐On‐Bound Dinitrogen Metal Complexes (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Parity declustering for continuous operation in redundant disk arrays (1992)

article Parity declustering for continuous operation in redundant disk arrays Share on Authors: Mark Holland View Profile , Garth A. Gibson View Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 27Issue 9Sept. 1992 pp 23–35https://doi.org/10.1145/143371.143383Online:01 September 1992Publication History 162citation686DownloadsMetricsTotal Citations162Total Downloads686Last 12 Months18Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
ChemInform Abstract: Dimeric Complexes Containing the (Fe2S2)2+ Cores Coordinated by Non‐Sulfur Terminal Ligands. Synthesis, Structural Characterization, and Spectroscopic Properties of (Et4N)2(Fe2S2(o,o′‐C12H8O2)2), (Et4N)2(Fe2S2(C4H4N)4), and (Et4N)2(Fe2S2(O‐o‐C6H4CH(n‐C4H9)NHC6H4‐o‐S)2) and the Structure of (Ph4P)2(Fe2S2(OC6H4‐p‐CH3)4). (1989)

Abstract The synthesis of the title complexes is achieved by metathetical stoichiometric reactions which occur in MeCN readily under strictly anaerobic and moisture‐free conditions between the anion of (I) and the alkali‐metal salts of the ligands.
Controlled delivery of platelet‐rich plasma‐derived growth factors for bone formation (2008)

Platelet-rich plasma (PRP) represents an autologous source of growth factors essential for bone regeneration. The clinical efficacy of PRP is, however, unpredictable, and this is likely due to the inefficient and inconsistent delivery of PRP-derived growth factors. Previous investigations have shown that current methods of PRP preparation result in a premature release of the relevant bone stimulatory factors. As successful bone regeneration requires multiple factors presented in a physiologic temporal and spatial cascade, the objective of this study is to control the bioavailability of PRP-derived growth factors using a hydrogel carrier system. Specifically, the release of platelet-derived growth factor, transforming growth factor beta-1, and insulin-like growth factor from two types of alginate carriers was compared over time. The effects of the released factors on the growth and alkaline phosphatase (ALP) activity of human osteoblast-like cells were also evaluated. It was found that factor release profiles varied as function of carrier type, and binding of growth factors to the alginate matrix also modulated their release. The bioactivity of released factors was maintained in vitro and they promoted cell proliferation and ALP activity. These results demonstrate the potential of this autologous multifactor delivery system for controlling the bioavailability of PRP-derived factors. Future studies will focus on optimizing this system to increase the clinical efficacy of PRP by matching the distribution and temporal sequencing of PRP-derived factors to the bone healing cascade.
Correlation Theory of Quantized Electromagnetic Fields. II. Stationary Fields and Their Spectral Properties (1967)

In Paper I of this investigation, dynamical laws which describe the space-time development of second-order coherence tensors of a quantized electromagnetic field in vacuo, and the associated conservation laws, were derived. In the first part of the present paper these results are specialized to stationary fields. Second-order cross-spectral tensors for such fields are then introduced, and some of their properties are discussed. A relation analogous to the Wiener-Khintchine theorem of the theory of stationary random processes is derived. Various non-negative-definiteness conditions obeyed by the cross-spectral tensors are established, and equations which govern the spatial variation of these tensors are deduced. Certain analytic properties of the correlation tensors are derived, and some of their consequences are examined. It is also shown that in the limiting case when the two space-time arguments of the coherence tensors coincide, two of our conservation laws reduce to the averaged form of the energy and the momentum conservation laws of the electromagnetic field.
Designing 3D Synthetic Matrices for Studying Interactions Between Bacterial Peptidoglycan and Macrophages in the Context of Immune Misrecognition Diseases (2020)

The immune system is a complex network comprised of various cellular components that work together to protect the body from damage, with a key function of differentiating between pathogenic bacteria and the 39 trillion commensal bacteria that constitute our microbiome. Misrecognition of commensal bacteria has been linked to many inflammatory bowel disorders in humans yet remains not fully understood and difficult to study. Enabled by recent advances in molecular tools, fragments of the bacterial cell wall peptidoglycan have been identified that bind to pattern recognition receptors within macrophages, which activate macrophages to start a signaling cascade that turns on the immune response. Typically, these interactions are studied using two‐dimensional invasion assays on tissue culture plastic plates; however, the dimensionality and ‘stiffness’ of these traditional culture systems may not be representative of the cell‐microenvironment interactions that exist in vivo . In order to better simulate the native cellular environment, three‐dimensional (3D) cell culture systems can be used to control key biochemical and mechanical properties of the cell microenvironment. Here, we established an approach for the encapsulation and culture of human macrophages in 3D within well‐defined, biomimetic hydrogels decorated with integrin binding peptides that mimic the natural in vivo environment and linked with cell‐degradable sites for cell‐driven migration and remodeling to probe macrophage response to bacterial invasion. With this approach, we have shown invasion with bacteria whose glycans are remodeled and their engulfment through immunostaining and assessed activation of macrophages using RT‐qPCR and ELISA. These studies provide new insights into the interactions between bacteria and immune cells and this new method affords unique opportunities for examining how our immune system recognizes and misrecognizes bacteria toward a better understanding of the mechanisms of immune misrecognition diseases. Support or Funding Information NIH CBI Training Grant‐5T32GM008550NIH U01 Common Fund program‐U01CA221230‐01
System Impact of 3D Processor-Memory Interconnect: A Limit Study (2011)

3D integration with through-silicon-vias (TSVs) can\nprovide enormous bandwidth between processor die and memory\ndie. The central goal of our work is to explore the limits\nof performance improvement that can be achieved with such\nintegration. Towards this end we propose a model of the\nimpact of 3D TSVs on system performance. The model leads\nto several key observations i) increased miss tolerance (smaller\ncaches) and hence improved core scaling for a fixed die size, ii)\nhigher sustained IPC per core, iii) significantly smaller, energy\nefficient DRAM banks, iv) redistribution of system power to\nthe cores and on -die interconnect, and v) TSV utilization is\na function of the relationship between reference locality and the\nbandwidth properties of the intradie network. These observations\nare repeated in cycle level simulations of a 64 tile architecture.
The Determination of Modal Damping Ratios From Maximum Entropy Spectral Estimates (1982)

This paper focusses on the estimation of natural frequencies and modal damping ratios from measured response spectra, with particular emphasis on the dynamic response of offshore structures to wind and wave excitation. At present, estimates of natural frequencies and damping ratios are computed from the location and half-power bandwidths of resonant peaks in a structure’s ambient response power spectrum. While reliable natural frequency estimates are typically obtained in this manner, half-power bandwidth damping estimates are shown to be highly sensitive to the method employed in estimating the response spectrum. The lack of confidence bounds on natural frequency and damping estimates further restricts the utility of the estimates. An alternative method is developed based on a powerful method of spectral estimation known as the Maximum Entropy Method (MEM). The resulting technique yields estimates of natural frequencies and modal damping ratios as well as approximate statistics on the reliability of the estimates. Performance of this new method is explored through extensive Monte Carlo simulation of one and two degree-of-freedom systems. Conventional estimates are also simulated for comparison with the MEM parameter estimator. The use of the MEM parameter estimator is further illustrated with ambient response data from Shell Oil’s South Pass 62C platform. The MEM parameter estimates show excellent agreement with natural frequency and damping estimates obtained during recent tests conducted using forced excitation.
Tetanus Toxin Inhibits Neuroexocytosis Even When Its Zn2+-dependent Protease Activity Is Removed (1995)

Tetanus toxin (TeTX) is a dichain protein that blocks neuroexocytosis, an action attributed previously to Zn(2+)-dependent proteolysis of synaptobrevin (Sbr) by its light chain (LC). Herein, its cleavage of Sbr in rat cerebrocortical synaptosomes was shown to be minimized by captopril, an inhibitor of certain metalloendoproteases, whereas this agent only marginally antagonized the inhibition of noradrenaline release, implicating a second action of the toxin. This hypothesis was proven by preparing three mutants (H233A, E234A, H237A) of the LC lacking the ability to cleave Sbr and reconstituting them with native heavy chain. The resultant dichains were found to block synaptosomal transmitter release, albeit with lower potency than that made from wild type LC; as expected, captopril attenuated only the inhibition caused by the protease-active wild type toxin. Moreover, these protease-inactive toxins or their LCs blocked evoked quantal release of transmitter when micro-injected inside Aplysia neurons. TeTX was known to stimulate in vitro a Ca(2+)-dependent transglutaminase (TGase) (Facchiano, F., and Luini, A. (1992) J. Biol. Chem. 267, 13267-13271), an affect found here to be reduced by an inhibitor of this enzyme, monodansylcadaverine. Accordingly, treatment of synaptosomes with the latter antagonized the inhibition of noradrenaline release by TeTX while not affecting Sbr cleavage. This drug also attenuated the inhibitory action of all the mutants. Hence, it is concluded that TeTX inhibits neurotransmitter release by proteolysis of Sbr and a protease-independent activation of a neuronal TGase.
T<sub>3</sub>Reverses the Changes in Met-Enkephalin and β-Endorphin Contents in the Anterior Lobe, But Not the Neuro-Intermediate Lobe of the Pituitary of Rats Rendered Hypothyroid by PTU-Treatment (1988)

The changes in met-enkephalin and beta-endorphin contents in the pituitary in PTU-induced hypothyroidism were studied in the rat. After 2 weeks of PTU-treatment, both IR-met-enkephalin and IR-beta-endorphin contents in the pituitary were significantly reduced. Gel filtration chromatography followed by radioimmunoassay showed that the immunoactivities in the peaks of precursors, met-enkephalin, beta-lipotropin and beta-endorphin were all lower in the pituitaries from the PTU-treated rats. In another experiment, some of the PTU-treated rats were injected daily with 500 micrograms T3/kg b.w. In the hypothyroid rats, IR-met-enkephalin and IR-beta-endorphin contents were decreased in both the anterior and neurointermediate lobes. Only the changes in the anterior lobe were reversed by T3 treatment. In conclusion, while the effects on the anterior lobe are probably due to a deficiency in thyroid hormones, the mechanism for the decrease of opioid peptide contents in the neurointermediate lobe is still unclear.
A New Sedative (Antipsychomotor) Drug Useful in Labor (1954)

THE ideal pharmacologic agent to manage the problem of pain relief in labor has yet to be developed. It should provide complete comfort for the mother and absolute safety for the baby without any essential alteration of the course of labor. The staff at the Boston Lying-in Hospital has taken an active interest in this problem for many years. Our most successful methods of obstetric amnesia and analgesia involve the use of limited amounts of barbiturates early in labor and scopolamine. However, this therapeutic regimen in about 5 to 10 per cent of cases may be associated with an undesirable . . .
Protocolo de análisis tectónico estructural para la caracterización de potenciales almacenamientos geológicos de CO2 (2008)

En el contexto del proyecto TECTO2 (CGL2006-28134-E/CLI) se esta realizando un protocolo de analisis tectonico estructural para la caracterizacion de almacenamientos geologicos de CO2. Este protocolo surge de la necesidad de estructurar y caracterizar una serie de metodologias que permitan cuantificar diferentes variables de caracter tectonico-estructural, de forma que se pueda establecer la idoneidad de una zona para el emplazamiento de un almacenamiento geologico de CO2. Este protocolo se pretende definir unos parametros tectonico-estructurales a partir de: 1) el establecimiento de tres escalas de analisis, 2) la definicion de los factores y variables que deben ser cuantificados en cada una de las escalas de analisis, y por ultimo, 3) en las diferentes metodologias necesarias para cuantificar esas variables. Para cada una de las escalas de trabajo, el protocolo TECTO2 describe la secuencia de aplicacion de las metodologias necesarias para cuantificar las variables adecuadas para la correcta caracterizacion tectonico-estructural de un almacenamiento geologico de CO2, aplicables tambien para el posterior seguimiento y control del emplazamiento.
Pollution atmosphérique Origine et réduction des émissions au niveau moteur (1994)

1 Pollution de l'air due aux moteurs thermiques 1.1 Effets des polluants sur la santé 1.2 Effets des polluants sur l'environnement 1.3 Origine des polluants automobiles 2 Formation des polluants dans la combustion 2.1 Formation des oxydes d'azote 2.2 Formation du monoxyde de car
Three dimensional waveguide splitters fabricated in glass using a femtosecond laser oscillator (2005)

Three-dimensional optical waveguide devices are fabricated in glass using femtosecond pulses from an extended cavity Ti:sapphire laser oscillator. We demonstrate increased device densities by fabricating highly symmetric 1:N waveguide splitters in three dimensions.
[Spongiosa formation in plate osteosynthesis--a comparative animal experiment study of current and auto-compression plates using the Zespol principle]. (1989)

Osteosynthesis with modern self-contracting plates has a few fundamental drawbacks apart from its undisputably good points. Among these drawbacks we have the pressure strain on the bone surface; the traction strain exercised by the screw thread in the bone; and, chiefly, spongiotisation and bone atrophy due to so-called stress protection. A new modification of this process, called Zespol, in which the plate is no longer fastened direct to the bone but is fastened floating over the bone surface to so-called platform screws, tries to solve these problems. In a comparative animal experiment tibial transverse osteotomies in the rabbit were treated by osteosynthesis using small fragmentary ACP and Zespol plates. In respect of healing of the fracture none of the two methods showed any advantage. Histological evaluation of the plated bone sections were characterised in both plate systems by increasing spongiotisation and bone atrophy that increased with the length of application. Degradation processes were about equal with both systems. A special feature with the Zespol animals was that the cleft originally existing between the plate and the bone was filled up with newly formed spongy and later cortical bone. Due to this process the original cortex layer lost its function and atrophied severely. After 12 to 18 weeks the bone surface had reached the lower side of the Zespol plate and there was contact by touch. This restored similar biomechanical conditions as those existing in conventional plates after this period.