gebhart/patrepeval huggingface dataset:
Parameterized model order reduction with guaranteed passivity for PEEC Circuit analysis (2010)

We present a novel parameterized model order reduction technique applicable to the Partial Element Equivalent Circuit analysis that provides parametric reduced order models, stable and passive by construction, over a user defined design space. We treat the construction of parametric reduced order models on scattered design space grids. This new parameterized model order reduction technique is based on the hybridization of traditional passivity-preserving model order reduction methods and interpolation schemes based on a class of positive interpolation operators, in order to guarantee overall stability and passivity of the parametric reduced order model. Pertinent numerical examples validate the proposed approach.
A potential regulatory region for the expression of fetal hemoglobin in sickle cell disease (1994)

We describe a 0.5-kb region located 1.65 to 1.15 kb upstream of the G gamma fetal globin gene with three polymorphisms of erythroid and ubiquitous nuclear protein binding motifs (GATA, CRE, and a new protein binding site). These three polymorphisms result in high-affinity and low-affinity motifs for nuclear proteins, and are combined in four arrangements called pre-G gamma frameworks (pG gamma Fs). Each pG gamma F is linked with one of the major haplotypes of the beta-globin gene cluster observed in sickle cell disease (SCD) associated with different mean levels of hemoglobin F (Hb F) expression (P < .001). This strong linkage and the differing affinities suggest that this region may be involved in the modulation of Hb F expression in SCD.
Fouling occuring in nanofiltration of dairy products (1995)

IDF Special Issue 9504. Part 1: Physico-chemical aspects of fouling chap. 4
A Correlation of Dew- and Bubble-point Curves for Binary Refrigerant Mixtures. (1991)

This paper reports a correlation of dew- and bubble-point curves for seven binary refrigerant mixtures of engineering importance. The present correlations have been established based upon the reliable measurements of dew- and bubble-points by the present authors and others using a constant volume method. We have made the present correlation by calculating the differences between the experimental values and the calculated values due to Raoult's law. After correlating these differences ΔPd or ΔPb with temperatures, we represented these temperature terms in terms of the composition x1 of the first Components which have lower critical temperature in binary components. It was confirmed that the present correlations for seven binary refrigerant mixtures were effective to model the dew- and bubble-point curves for any mixtures with an arbitrary composition, and to reproduce the dew- and bubble-point pressures even in the neighborhood of the critical points where the SRK equation did not reproduce the measured vapor-liquid equilibrium.
Rotaviruses Associated with Neonatal Lamb Diarrhea in Two Wyoming Shed-Lambing Operations (1996)

White scours was first recognized in 1927 as an important cause of newborn lamb loss in shed-lambing operations in the western United States. 4 This disease was thought to be caused by bacteria, but no specific pathogen was identified. Lamb scours remains an important disease in the United States, 3 and several bacteria are now considered etiologic agents, including Bacteroides fragilis 5 and K99 piliated, enteropathogenic Escherichia coli. 11 Moreover, the coccidian parasite Cryptosporidium also has been associated with diarrhea in young lambs. 1 Viruses associated with neonatal lamb diarrhea were not reported in the United States until very recently. 7 In this instance, group B rotavirus was detected during an outbreak of diarrhea in newborn confinement-reared lambs in Ohio. Each spring during the past 5 years, several large shedlambing operations in eastern Wyoming have experienced severe outbreaks of neonatal diarrhea associated with high morbidity and mortality. The purpose of this study was to determine if any potentially pathogenic enteric viruses could be detected by negative-stain electron microscopic (EM) examination of specimens collected from neonatal diarrheic lambs in 2 of these operations. In early April 1994, specimens were collected from affected lambs in 2 eastern Wyoming shed-lambing operations situated about 40 km apart. Ranch A routinely shed-lambs over 1,300 lambs within a 30-day period commencing in early March. In some years the first scouring lambs were observed during the first week of shed-lambing, whereas in other years they occurred later. Clinical signs were observed when the lambs were 12-16 hours old and consisted of frothy salivation, inappetence, and scours. Some affected lambs died within 4-5 hours following the onset of signs; surviving lambs, however, often gained weight slowly and were prone to other infectious diseases. Once the outbreak was under way, morbidity approached 100%, and about 10% of the affected lambs died. Ranch B routinely shed-lambs between 3,000 and 5,000 lambs within a 30-day period starting in early March. Affected lambs were not ordinarily observed during the first week, but sometime afterward a lamb would become ill while still in the lambing pen. Within 4-5 days after the first case, many lambs were affected, and thereafter the majority of the lambs kept in the shed area became ill. Initial clinical signs
Pediatric psychotropic polypharmacy. (2005)

There is limited information about the actual rates of psychotropic polypharmacy in the pediatric population. However, the data that are available demonstrate that this practice is on the rise. This is of specific concern due to the increase of adverse events with polypharmacy. The implications of polypharmacy, including efficacy and side effects, are generally unknown and may vary by specific combination. Therefore, these prescribing practices should be conducted with caution, and systematic research is needed.
Maturation of somatostatin immunoreactivity in the pigeon retina: Morphological characterization and quantitative analysis (1994)

In addition to a modulatory function, somatostatin (SS) is likely to exert a morphogenetic and/or trophic role in the developing nervous system. In this study, a mouse monoclonal antibody directed to SS was used to investigate the posthatching development of SS-immunoreactivity (SS-ir) in the pigeon retina to provide a basis for a better understanding of the role of this peptide in retinal maturation. In the adult, SS-ir was observed in amacrine cells located in the inner nuclear layer (INL) of the entire retina. Two cell types were recognized according to their morphology. They showed a differential density distribution. Cell type indicated as "adult 1" (AD1) was characterized by pear-shaped cell bodies with single primary processes directed to the inner plexiform layer (IPL) and was mostly present in the red field. In contrast, cell type indicated as "adult 2" (AD2) was characterized by round-shaped somata with 1-3 primary processes and was highly represented in the fovea and the dorsal periphery. Posthatching maturation of the pigeon retina was characterized by drastic changes in the pattern of SS-ir. Over the first days posthatching, SS-ir was observed in sparsely distributed somata mostly located in the ganglion cell layer (GCL). This cell type indicated as "hatch" (H) was characterized by dense granular staining and became extremely rare at 7 days. Over the same period, growing SS-positive axons displaying enlarged growth cones were found in the optic tract (TrO). These observations suggest the possibility that ganglion cells transiently expressing SS are present at early stages of posthatching development. Of the two types of SS-containing cells observed in the adult, the first to be recognized morphologically was cell type AD1 which appeared at 2 days after hatching in the INL. These cells were virtually adult-like in morphology by 7 days. In contrast, cell type AD2 was not apparent until 7 days posthatching. The density (defined as number of cells/mm2 of retinal tissue) and the total number of SS-containing cells changed during posthatching maturation. In particular, the adult number of cell type AD1 was reached at about 10 days, while the number of cell type AD2 was reached at about 3 weeks posthatching. At this stage, both cell types also displayed their mature density distribution. The present findings suggest a temporal relationship between the maturation of SS-ir and developmental events which include the onset of light-driven activity and the maturation of retinal acuity.(ABSTRACT TRUNCATED AT 400 WORDS)
ChemInform Abstract: 4,5,6,7‐TETRAHYDROBENZO(B)THIOPHENES VIA DIISOBUTYLALUMINUM HYDRIDE MEDIATED DETOSYLATION REACTIONS (1980)

Abstract Die Tosylverbindungen (II) werden reduktiv zu (I) detosyliert.
Hatching and Attachment of Rat Blastocysts in vitro (1977)

ラットの4日齢初期胚盤胞および5日齢胚盤胞の体外における着床現象を観察した.ラットの初期胚盤胞および胚盤胞を体外で3-4日間培養すると,透明帯が消失しガラス壁に付着し,さらに発育を続ける現象が観察されたが,その時間的推移から体内における着床類似の現象と考えられた.培養液に血漿あるいは血清を加えない場合はガラス壁への付着は全くみられず,付着する卵子の割合は培養液中の血漿濃度が高くなるにしたがって増加した.非動化した家兎,モルモット,ヤギおよびラット血清を加えた培養液ではいずれも付着現象がみられたが,無処置血清を加えた場合はヤギおよびラット血清でのみ付着がみられた.
Extracellular nucleotides as signalling molecules for renal mesangial cells (1996)

1. Glomerular diseases frequently cause chronic renal failure which ultimately requires dialysis and kidney transplantation. The events leading to destruction of the glomerular filtration apparatus include injury of glomerular cells, aggregation of thrombocytes and infiltration of immune cells into the glomerulus. 2. Nucleotides (e.g. ATP and UTP) are present in all glomerular cell types as well as in thrombocytes. The release of nucleotides into the extracellular space occurs after damage of glomerular cells and aggregation of thrombocytes. Several in vitro and in vivo findings indicate that extracellular nucleotides may play a role as pro-inflammatory mediators in glomerulonephritis. 3. A hallmark finding in kidney biopsies from patients with glomerulonephritis is proliferation of glomerular mesangial cells. Cell culture studies demonstrated that extracellular ATP (10-300 microM) stimulated growth of mesangial cells. The mitogenic effect of ATP was potentiated in the presence of multiple growth factors. 4. Nucleotide-induced signalling in mesangial cells included an increase of intracellular calcium, activation of phosphatidylinositol-specific phospholipase C and phospholipase D, inhibition of adenylylcyclase, stimulation of mitogen-activated protein kinase and increased expression of the immediate early genes, c-fos, c-jun and Egr-1. 5. In previous studies of experimental mesangioproliferative glomerulonephritis, exogenously given ADP beta S and ATP gamma S have been shown to aggravate the course of the disease, while 2-chloroadenosine had beneficial effects. 6. Taken together, these findings support the concept that nucleotides may function as proinflammatory mediators in glomerulonephritis while adenosine may have antiinflammatory effects.
NANOSTRUCTURE OF <font>TiO</font><sub>2</sub> THIN FILMS PREPARED BY UNBALANCED MAGNETRON SPUTTERING (2009)

In this study, titanium dioxide ( TiO 2 ) thin films were deposited on unheated glass substrates using an unbalanced magnetron sputtering system with different deposition times of 25, 35 and 45 min, respectively. The structure and surface morphology of TiO 2 thin films were characterized by atomic force microscopy (AFM) and transmission electron microscopy (TEM) with selected-area electron diffraction (SAED). It was found that the crystallite size of TiO 2 thin films was in the range of 10–20 nm, and the surface roughness was 1–3 nm. The SAED patterns show that the phase of TiO 2 thin films obtained in this study is anatase phase.
Novel Locus for an Inherited Cardiomyopathy Maps to Chromosome 7 (2006)

The discovery of a novel genetic locus in this family provides more evidence that molecular pathways leading to inherited cardiac hypertrophy extend beyond the sarcomere. Identification of the causal gene mutation and additional genotype-phenotype correlation studies will provide fundamental insight into mechanisms of cardiac remodeling.
CME (2014)

Spondylitis = entzündliche Veränderung eines oder mehrerer Wirbelkörper.Diszitis = entzündliche Veränderung einer Bandscheibe.Die Spondylodiszitis ist eine Knochenentzündung der Wirbelkörper und der angrenzenden Bandscheibe.Sie ist meistens die Folge einer hämatogenen Streuung,
Ground state of a quantum disk by the effective-index method (1995)

A simple method for obtaining a good approximation of the ground state of a quantum disk is presented in the case where the electron radial confinement is substantial. Developed in the envelope-function formalism, the method is derived from the effective-index technique well known to dielectric wave-guide theory. Its validity is discussed by comparing its results with those obtained using a numerical relaxation technique.
Genetic linkage but independent expression of functional HSV-1 <i>tk</i> and mammalian <i>aprt</i> genes after cotransfer to L cells (1985)

DNA-mediated gene transformation of mouse Ltk-aprt-hprt-cells was used to obtain stable, doubly selected transformants simultaneously expressing herpes virus thymidine kinase (TK) and mammalian adenine phosphoribosyltransferase (APRT). Cotransformants occurred at a frequency of 5 X 10(-6), a similar frequency for the transfer of the aprt marker has been previously observed. Isozyme and Southern blot analysis show that the TK and APRT expressed in these transformants resulted from gene transfer. For one stable cotransformant, [3H]thymidine [( 3H]TdR) selection against TK activity resulted in the loss of APRT activity as well, suggesting that these genes had become genetically linked together. Similarly selection against APRT expression resulted in the loss of a subset of the transferred herpes simplex virus tk genes. 5-Bromodeoxyuridine (BUdR) selected TK- variants differed from [3H]TdR selected TK- variants, in that they retained tk genes. However, BUdR-selected variants expressed full levels of APRT. Therefore, even though the transferred tk and aprt genes had become genetically linked together, they were, in this case, independently expressed since these cells were phenotypically TK- and APRT+.
Functional magnetic resonance imaging assessment of cognitive function in childhood‐onset systemic lupus erythematosus: A pilot study (2007)

FMRI abnormalities are present in childhood-onset SLE, manifesting as an imbalance between active and inhibitory responses to an array of stimuli. Differences in brain activation patterns compared with those observed in controls suggest that childhood-onset SLE may be associated with abnormalities in white matter connectivity resulting in neuronal network dysfunction, rather than injury of specific gray matter areas.
The two Staphylococcal bi‐component toxins, leukocidin and gamma‐hemolysin, share one component in common (1993)

Staphylococcal bi-component toxins, leukocidin and gamma-hemolysin, consist of two protein components, i.e. F and S for leukocidin and H gamma I and H gamma II for gamma-hemolysin. In this study we purified H gamma I and H gamma II to homogeneity from the culture medium of Staphylococcus aureus RIMD 310925 and compared their properties with those of F and S purified from the same source. The N-terminal 59- and C-terminal 2-residue amino acid sequences, apparent molecular mass, and isoelectric point of purified H gamma I were the same as those of F. In an Ouchterlony double diffusion test a fused line without spur was formed between F and H gamma I using either anti-F or anti-H gamma I antibodies. A synergistic action of F and H gamma II caused hemolysis of human red blood cells, and H gamma I acted synergistically with S to exhibit leukocidin activity. We conclude that the two toxins share one protein component (F = H gamma I) in common and leukocidin- and gamma-hemolysin-specific activities are determined by S and H gamma II, respectively. It is also reported that the N-terminal 58-residue sequence of H gamma II is 72% similar to the corresponding sequence of S.
CHARACTERISTICS OF THE SCYLLACITA theta-PINCH. (1968)

Polyhydroxyalkanoate (PHA) recovery from microbial cells relies on either solvent extraction (usually using halogenated solvents) and/or digestion of the non-PHA cell mass (NPCM) by the action of chemicals (e.g., hypochlorite) that raise environmental and health hazards. A greener alternative for PHA recovery, subcritical water (SBW), was evaluated as a method for the dissolution of the NPCM of a mixed microbial culture (MMC) biomass. A temperature of 150 °C was found as a compromise to reach NPCM solubilization while mostly preventing the degradation of the biopolymer during the procedure. Such conditions yielded a polymer with a purity of 77%. PHA purity was further improved by combining the SBW treatment with hypochlorite digestion, in which a significantly lower hypochlorite concentration (0.1%, <i>v/v</i>) was sufficient to achieve an overall polymer purity of 80%. During the procedure, the biopolymer suffered some depolymerization, as evidenced by the lower molecular weight (M<sub>w</sub>) and higher polydispersity of the extracted samples. Although such changes in the biopolymer's molecular mass distribution impact its mechanical properties, impairing its utilization in most conventional plastic uses, the obtained PHA can find use in several applications, for example as additives or for the preparation of graft or block co-polymers, in which low-M<sub>w</sub> oligomers are sought.
Hydrops fetalis due to placental chorioangioma: report of one case. (1997)

Chorioangioma is the most common tumor of the placenta. However, a large one complicated with hydrops fetalis is rare. We report a patient who had hydrops fetalis associated with placental chorioangioma. The clinical manifestations included generalized edema, coagulopathy, thrombocytopenia, anemia, hypoproteinemia and hepatosplenomegaly. The hospital course was complicated with acute renal failure and repeated pneumonia. The patient died on the 54th day of life due to persistent lung atelectasis and hypovolemic shock. The pathophysiology and management of the complications of hydrops fetalis with chorioangioma are discussed.
On the Fluctuation of Gas Utilization Ratio in Blast Furnace (1967)

53(1967)11 Table 3. Amount and depth of nitriding
Optimal Control of the Obstacle in Semilinear Variational Inequalities (2007)

We consider an optimal control problem where the state satis es an obstacle type semilinear variational inequality and the control function is the obstacle. The state is chosen to be close to a desired profile while the obstacle is not too large in H 4 and -bounded. We prove that an optimal control exists and give necessary optimality conditions, using approximation techniques.
High-frequency InP/InGaAs pin photodiodes with efficient response at short wavelengths (2002)

It is shown that InP-based pin photodiodes can be operated at high frequency with high quantum efficiency over a broad range of wavelengths (0.6-1.6 mu m). Good window layers for high-speed detectors can be made with n/sup ++/ InP for two reasons: the high carrier concentration enables low sheet resistance to be obtained with very thin layers, and the Burstein-Moss effect significantly reduces the absorption coefficient of the layer in the lambda =0.7-0.9 mu m range. This provides a low-resistance cap layer that is highly transparent over the lambda =0.7-1.6 mu m range and is lattice-matched to the InGaAs(P) active layer. At lambda =0.86 mu m, the detectors demonstrate a flat heterodyne response up to 3 GHz, with 3-dB roll-off of 8 GHz and DC quantum efficiency of approximately 80%. Their current-carrying capability makes them attractive for use in systems that require high local-oscillator power. The detectors are well suited for use with all the semiconductor laser sources available the traditional AlGaAs/GaAs and InP/InGaAsP as well as the new, strained-layer, quantum-well InGaAs/AlGaAs/GaAs and InGaAs/InGaP/GaAs lasers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Chirped-pulse stimulated Raman scattering in barium nitrate with subsequent recompression (2001)

We report a 30% internal conversion efficiency for the first Stokes pulse in stimulated Raman scattering of femtosecond pulses that are dispersively stretched to 250 ps, obtained by use of an all-solid-state laser system. A transfer of the linear chirp is observed, leading to a Raman pulse duration of 190 fs after recompression. Compressed pulse energies of 80 muJ at a repetition rate of 1 kHz are obtained, with a potential for an easy increase to more than 150 muJ. The temporal and spectral characteristics of the Raman and pump pulses are calculated, and the results explain the observed transient features in the presence of chirp.
MDL 29311: Antioxidant With Marked Lipid- and Glucose-Lowering Activity in Diabetic Rats and Mice (1993)

MDL 29311, an analogue of probucol, administered to rats as a 1% dietary admixture for 2 wk before and 5 days after intravenous injection of 40 mg/kg of ALX significantly (P &lt; 0.05) reduced plasma glucose (6.9 ± 0.3 vs. 19.2 ± 1.3 mM) and serum triglyceride (0.17 ± 0.01 vs. 1.82 ± 0.39 mM) levels in overnight-fasted ALX-plus-MDL 29311-administered rats vs. ALX-administered rats. A cross-over study indicated that MDL 29311 did not attenuate the diabetogenic action of ALX, but rather, directly lowered glucose and triglycerides. In rats injected intravenously with 45, 65, or 85 mg/kg of STZ and then administered control or MDL 29311 diet for 7 days, MDL 29311 decreased fasted plasma glucose to nondiabetic levels, decreased fasted and nonfasted plasma triglycerides by 49–79%, but did not affect plasma insulin levels. In STZ-induced (65 mg/kg) diabetic rats, MDL 29311 attenuated the increase in plasma nonesterified fatty acids during an 18-h fast; had little or no effect on glucagon, pyruvate, lactate, β-hydroxybutyrate, acetoacetate, or cholesterol; and did not induce hypoglycemia in rats fasted up to 64 h. In nonfasted hyperinsulinemic db/db mice treated for 10 wk, MDL 29311 significantly lowered glucose levels by 14–40%, triglyceride levels by 31–63% and GHb from 8.0 to 5.4%, and had no consistent effect on plasma insulin levels. Because of its marked glucose- and lipid-lowering activity in both nonfasted hyperinsulinemic and fasted insulinopenic animals, MDL 29311 merits additional investigation as a potential antidiabetic agent.
A framework of software rejuvenation for survivability (2004)

We propose a novel approach of the security issue to survivability. The main objectives are to detect the attacks in real time, to characterize the attacks, and to survive in face of the attacks. To counteract the attacks' attempts, we perform the software rejuvenation methods (SWRMS) such as killing the intruders' processes in their tracks, halting abuse before it happens, shutting down unauthorized connection, and responding and restarting in real time. These slogans will really frustrate and deter the attacks, as the attackers can't make their progress. This is a way of survivability to maximize the deterrence against the attacks in the target environment. We address a framework to model and analyze the critical intrusion tolerance problems ahead of intrusion detection and we present a set of innovative models to solve the security aging problems.
Oxidative C–H/C–H Coupling of Azine and Indole/Pyrrole Nuclei: Palladium Catalysis and Synthesis of Eudistomin U (2011)

Abstract We have developed a palladium-catalyzed C–H/C–H coupling reaction of indoles or pyrroles with azine N-oxides. The reaction proceeds selectively at the C3 position of indoles/pyrroles and the C2 position of azine N-oxides. Furthermore, we have accomplished the synthesis of marine indole alkaloid eudistomin U by utilizing this newly developed C–H/C–H coupling reaction.