gebhart/patrepeval huggingface dataset:
Relationships of consumer sensory ratings, marbling score, and shear force value to consumer acceptance of beef strip loin steaks (2003)

Logistic regression was used to quantify and characterize the effects of changes in marbling score, Warner-Bratzler shear force (WBSF), and consumer panel sensory ratings for tenderness, juiciness, or flavor on the probability of overall consumer acceptance of strip loin steaks from beef carcasses (n = 550). Consumers (n = 489) evaluated steaks for tenderness, juiciness, and flavor using nine-point hedonic scales (1 = like extremely and 9 = dislike extremely) and for overall steak acceptance (satisfied or not satisfied). Predicted acceptance of steaks by consumers was high (> 85%) when the mean consumer sensory rating for tenderness,juiciness, or flavor for a steak was 3 or lower on the hedonic scale. Conversely, predicted consumer acceptance of steaks was low (< or = 10%) when the mean consumer rating for tenderness, juiciness, or flavor for a steak was 5 or higher on the hedonic scale. As mean consumer sensory ratings for tenderness, juiciness, or flavor decreased from 3 to 5, the probability of acceptance of steaks by consumers diminished rapidly in a linear fashion. These results suggest that small changes in consumer sensory ratings for these sensory traits have dramatic effects on the probability of acceptance of steaks by consumers. Marbling score displayed a weak (adjusted R2 = 0.053), yet significant (P < 0.01), relationship to acceptance of steaks by consumers, and the shape of the predicted probability curve for steak acceptance was approximately linear over the entire range of marbling scores (Traces67 to Slightly Abundant97), suggesting that the likelihood of consumer acceptance of steaks increases approximately 10% for each full marbling score increase between Slight to Slightly Abundant. The predicted probability curve for consumer acceptance of steaks was sigmoidal for the WBSF model, with a steep decline in predicted probability of acceptance as WBSF values increased from 3.0 to 5.5 kg. Changes in WBSF within the high (> 5.5 kg) or low (< 3.0 kg) portions of the range of WBSF values had little effect on the probability of consumer acceptance of steaks.
Non-invasive volumetric analysis of asymptomatic hands using a 3-D scanner (2017)

Hand swelling is one of the symptoms often seen in practice, but none of the available morphometric methods can quickly and efficiently quantify hand volume in an objective manner, and the current gold-standard volume measurement requires immersion in water, which can be difficult to use. Therefore, we aimed to analyze the accuracy of using 3-dimensional (3-D) scanning to measure hand volume. First, we compared the hand volume calculated using the 3-D scanner to that calculated from the conventional method among 109 volunteers to determine the reliability of 3-D measurements. We defined the beginning of the hand as the distal wrist crease, and 3-D forms of the hands were captured by the 3-D scanning system. Second, 238 volunteers (87 men, 151 women) with no disease or history of hand surgery underwent 3-D scanning. Data collected included age, height, weight, and shoe size. The wrist circumference (WC) and the distance between distal wrist crease and tip of middle finger (DDT) were measured. Statistical analyses were performed using linear regression to investigate the relationship between the hand volume and these parameters. In the first study, a significantly strong positive correlation was observed [R = 0.98] between the hand volume calculated via 3-D scanning and that calculated via the conventional method. In the second study, no significant differences between the volumes, WC or DDT of right and left hands were found. The correlations of hand volume with weight, WC, and DDT were strong. We created a formula to predict the hand volume using these parameters; these variables explained approximately 80% of the predicted volume. We confirmed that the new 3-D scanning method, which is performed without touching the hand and can record the form of the hand, yields an accurate volumetric analysis of an asymptomatic hand.
Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy (2014)

Separase is an endopeptidase that cleaves cohesin subunit Rad21, facilitating the repair of DNA damage during interphase and the resolution of sister chromatid cohesion at anaphase. Separase activity is negatively regulated by securin and Cdk1-cyclin B in vivo. Separase overexpression is reported in a broad range of human tumors, and its overexpression in mouse models results in tumorigenesis. To elucidate further the mechanism of separase function and to test if inhibition of overexpressed separase can be used as a strategy to inhibit tumor-cell proliferation, small-molecule inhibitors of separase enzyme are essential. Here, we report a high-throughput screening for separase inhibitors (Sepins). We developed a fluorogenic separase assay using rhodamine 110-conjugated Rad21 peptide as substrate and screened a small-molecule compound library. We identified a noncompetitive inhibitor of separase called Sepin-1 that inhibits separase enzymatic activity with a half maximal inhibitory concentration (IC50) of 14.8 µM. Sepin-1 can inhibit the growth of human cancer cell lines and breast cancer xenograft tumors in mice by inhibiting cell proliferation and inducing apoptosis. The sensitivity to Sepin-1 in most cases is positively correlated to the level of separase in both cancer cell lines and tumors.
Electron transport across metal/discotic liquid crystal interfaces (1998)

Electron transport across micron thick films of columnar hexagonal discotic liquid crystal phases homeotropically aligned between metal electrode surfaces has been studied both experimentally and theoretically. These molecules are unique in their combination of charge transport along individual molecular columns with liquidlike self-organization. Typical of organic insulators, a high resistance Ohmic regime is evident at fields of less than 0.05 MV cm−1, due to a low concentration of chemical impurities (n&lt;109 cm−3), and a space-charge injection regime at higher fields. Breakdown fields are reasonably high: in hexakis(hexyloxy)triphenylene they reach ∼5 MV cm−1 at room temperature. Our results show that triphenylene-based discotics form an excellent class of highly ordered optically transparent insulators. At high temperatures and high fields the current is injection controlled and exhibits typical tunneling and space charge limited, nonlinear I–V characteristics. Dramatic jumps in injection currents are observed at phase transitions. The change at the crystalline to liquid crystalline phase transition is mainly due to more efficient “wetting” of the electrode surface in the liquid crystalline phase, whilst at the liquid crystalline to isotropic phase transition it arises from the enhancement in the molecular mobility. The concepts of semiconducting gaps, band mobilities, and carrier injection rates are extended to these new materials. The experimental observations are interpreted in a framework which takes into account the important role played by liquidlike dynamics in establishing the microscopic structural order in, what is, otherwise a highly anisotropic and weakly bonded “molecular crystal.”
Characterization of the ATP‐dependent leukotriene C<sub>4</sub> export carrier in mastocytoma cells (1994)

The biosynthesis of leukotriene C4 (LTC4) must be followed by an export of this mediator into the extracellular space where it interacts with receptors. Using mastocytoma cells we have demonstrated the existence of a primary-active, ATP-dependent transport mediating this export of LTC4 [Schaub, T., Ishikawa, T. & Keppler, D. (1991) FEBS Lett. 279, 83-86]. The following inhibitors served to characterize further this transport system in plasma membrane vesicles from mastocytoma cells: Probenecid, an inhibitor of organic anion transport, induced half-maximal inhibition of the ATP-dependent LTC4 transport at 71 microM. Cyclosporin A and its non-immunosuppressive analog PSC 833 inhibited the ATP-dependent transport with Ki values of 4.5 microM and 30 microM, respectively. The LTD4 receptor antagonist 3-([(3-(2-[7-chloro-2-quinolinyl]ethenyl)phenyl)-[(3-dimethylamino-3- oxopropyl)-thio]-methyl]thio)propanoic acid (MK 571) was the most potent competitive inhibitor of the export carrier with a Ki value of 0.8 microM. The transport inhibitor MK 571 served as competitor in the photoaffinity labeling of LTC4-binding membrane proteins using [3H]LTC4 as the photolabile ligand. Proteins with molecular masses of about 190 kDa and 35 kDa were predominantly labeled. In addition, a minor [3H]LTC4 labeling was observed in the molecular mass range of 100 kDa. The [3H]LTC4 labeling of the 190-kDa protein was competed for by MK 571. The labeled proteins resisted extraction from the membrane with 2% sodium taurocholate suggesting that they are integral membrane proteins. Treatment of the membrane proteins with peptide N-glycosidase F resulted in the appearance of an additional labeled polypeptide of about 140 kDa suggesting that the 190-kDa protein is a glycoprotein. Photoaffinity labeling with 8-azido[alpha-32P]ATP predominantly labeled the LTC4-binding 35-kDa protein. The [3H]LTC4-labeled 190-kDa protein showed a mean isoelectric point at pH 6.3 with a range of pH 5.8-6.7, while the 35-kDa protein had an isoelectric point at pH 6.8. Specific labeling of a 190-kDa membrane glycoprotein by the glutathione conjugate LTC4, which is competed for by a potent inhibitor of the ATP-dependent LTC4 export carrier, pinpoints its involvement in the ATP-dependent transport of LTC4 and related conjugates.
System Dependency and Social Identity Salience: A Comment on Bonnot and Krauth-Gruber (2017) (2016)

This brief commentary discusses the following paper: Bonnot, V., & Krauth‐Gruber, S. (2017). System‐justifying behaviors: When feeling dependent on a system triggers gender stereotype‐consistent academic performance. <i>European Journal of Social Psychology</i>. doi: 10.1002/ejsp.2201 It is proposed that (1) manipulations of system dependency may also manipulate social identity salience, (2) measures of system dependency may also measure social identity salience, and consequently that (3) social identity salience can explain the effects of system dependency. This proposal is consistent with recent claims that personal and/or group motives (personal and/or social identity) can explain system justification effects more parsimoniously than system justification theory’s proposition that these effects are motivated by a separate system justification motive.
Acoustic source localization using the acoustic ENSBox (2007)

Field biologists use animal sounds to discover the presence of individuals and to study their behavior. The recent development of new deployable acoustic sensor platforms presents opportunities to develop automated tools for bio-acoustic field research. In this work, we demonstrate a real-time wireless sensor system that implements an AML-based source localization algorithm. We will demonstrate a system that is easy to set up and that can localize a whistle in the demonstration area in real time. This demonstration will use the techniques we described in our corresponding paper [1].
Fast Attitude Maneuvers for the Lunar Reconnaissance Orbiter (2019)

This paper describes a new operational capability for fast attitude maneuvering that is being developed for the Lunar Reconnaissance Orbiter (LRO). The LRO hosts seven scientific instruments. For some instruments, it is necessary to perform large off-nadir slews to collect scientific data. The accessibility of off-nadir science targets has been limited by slew rates and/or occultation, thermal and power constraints along the standard slew path. The new fast maneuver (FastMan) algorithm employs a slew path that autonomously avoids constraint violations while simultaneously minimizing the slew time. The FastMan algorithm will open regions of observation that were not previously feasible and improve the overall science return for LRO’s extended mission. The design of an example fast maneuver for LRO’s Lunar Orbiter Laser Altimeter that reduces the slew time by nearly 40% is presented. Pre-flight, ground-test, end-to-end tests are also presented to demonstrate the readiness of FastMan. This pioneering work is extensible and has potential to improve the science data collection return of other NASA spacecraft, especially those observatories in extended mission phases where new applications are proposed to expand their utility.
An Advanced Roughness Spectrum for Computing Microwave L-Band Emissivity in Sea Surface Salinity Retrieval (2010)

The influence of sea surface roughness dominates the error budget of satellite sea surface salinity (SSS) retrieval from L-band radiometers; thus, accurate roughness correction models are needed. Semi-analytical SSS correction models, as used in the soil moisture and ocean salinity satellite Level 2 processor, combine an emissivity model with an ocean wave spectrum model that describes the rough sea surface. Previous findings indicate that the errors contributed by ocean roughness model exceed those of the emissivity model. In this paper, we compare the performance of three well-known spectrum models and a new one as inputs to the small slope approximation/small perturbation method emissivity model. The new spectrum model, which is developed from empirical parameterization of short water wave spectra measured in the ocean and incorporates swell effects, performs very well in comparison with the other spectrum models, and we propose its consideration for future SSS roughness correction models.
GENOMIC FUNCTION DURING THE LAMPBRUSH CHROMOSOME STAGE OF AMPHIBIAN OÖGENESIS (1966)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Algorithms with Conic Termination for Nonlinear Optimization (1989)

This paper describes the implementation of algorithms for unconstrained optimization which have the property of minimizing conic objective functions in a finite number of steps, when line searches are exact. This work extends the algorithms of Davidon [“Conjugate directions for conic functions” in Nonlinear Optimization 1981, M.J.D. Powell, ed., Academic Press, London, 1981] and Gourgeon and Nocedal [SIAM J. Sci. Statist. Comput., 6 (1985), pp. 253–267] to general nonlinear objective functions, paying much attention to the practical behavior of the new methods. Three types of algorithms are described; they are extensions of the conjugate gradient method, the BFGS method, and a limited-memory BFGS method. The numerical results show that new methods are very effective in solving practical problems.
1P140 Halide ion effect on hydration state of F-actin(10.Muscle,Poster,The 51st Annual Meeting of the Biophysical Society of Japan) (2013)

Water should play a key role in muscle contraction (
Acte de Congrès : "Removal of textile dyes from waste water by ceramic ultrafiltration membrane" (2005)

Proceeding of Watmed 2 International Conference, Marrakech, November 14-17, 2005
Computer Insight into the Molecular Level of Heart Failure. What is the Role of NCX? (2008)

Though congestive heart failure is a leading cause of death in our population, the pathophysiological mechanisms at molecular level remain to be elucidated. This paper discusses the contribution of NCX to the pathological pattern of intracellular calcium regulation and contraction on the basis of computer simulations of a virtual cell. The model comprises calcium handling mechanisms, troponin control and acto-myosin interactions. The contribution of NCX was studied by changing its activity and turning it off for some simulations.It was found that NCX helps to support diastolic function by reducing the Ca2 level during the diastole. At the same time there is a reduction in peak Cai and hence contraction. However, increased NCX activity does not seem to improve calcium handling and contraction crucially, as has been suggested by some authors.
Characterization of organic packing materials in the removal of ammonia gas in automated biofilters (2005)

A fully-automated pilot-scale biofilter filled with coconut fiber as packing material was investigatedfor treatment of ammonia-containing off-gas streams. Coconut fiber was completely characterized forphysical and chemical parameters and biological activity. Biofilter performance was assessed in a pilot-scale unit in a set of continuous experiments varying the inlet ammonia concentration in a range of 45 to240 ppmv at a gas contact time of 36 seconds. Samples taken along the bed height as well as inlet and outletammonia concentrations were used to determine a maximum elimination capacity of 12 g NH3m?3h?1ata 80% removal efficiency. Some features related to nitrification inhibition encountered in the experimentsare also discussed.
High Temperature during Grain Filling Impacts on Leaf Senescence in Waxy Maize (2017)

Core Ideas Heat stress decreased the translocation of dry matter from vegetative organs after pollination. Heat stress during grain filling accelerated leaf senescence of waxy maize. This study provides leaf senescence and dry matter translocation data for waxy maize production. Waxy maize ( Zea mays L. sinensis Kulesh) is frequently exposed to high temperatures (higher than 35.0°C) during grain filling in southern China. This pot trial was conducted to study the effect of heat stress during grain filling on grain yield, dry matter (DM) accumulation and translocation, and leaf senescence of plants. Post‐pollination plants of Suyunuo 5 and Yunuo 7 (waxy maize varieties) were planted under high temperature (35.0°C) and ambient temperature conditions (daytime temperatures during grain filling were 29.0 and 28.2°C in 2014 and 2015, respectively).The decrease rate of grain yields for Suyunuo 5 and Yunuo 7 were 31.3 and 21.9% due to the reduced grain number and weight, respectively, indicating that Suyunuo 5 was more sensitive to heat stress. Heat stress decreased dry matter accumulation after pollination (DMA) . The photosynthate of vegetative organ post‐pollination translocated to grain decreased by 36.1 and 55.9% for Yunuo 7 and Suyunuo 5, respectively. However, the translocation amount and rate of assimilates pre‐pollination increased, with greater increase observed in Suyunuo 5. The malondialdehyde (MDA) content was increased by heat stress 25 and 20 d after pollination in Yunuo 7 and Suyunuo 5, respectively. Leaf chlorophyll (Chl), carotenoid (Car), and soluble protein contents were decreased, and the activities of antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], and peroxidase [POD]) were suppressed by heat stress in both varieties. The findings suggested that reduced DMA and accelerated leaf senescence under heat stress post‐pollination result in the grain yield loss.
Microwave-Assisted Regioselective Benzylation: An Access to Glycal Derivatives with a Free Hydroxyl Group at C4 (2012)

D-glucal, D-galactal, and their 6-O-TBDMS derivatives were benzylated in a two-step procedure under microwave conditions. In the first step glycals were converted into dibutylstannylene acetal or tributyltin ether intermediates, which were next alkylated with benzyl bromide in the presence of Bu4NBr. In all cases the 4-OH group stayed unsubstituted. Microwave-assisted benzylation contributes to a significant reduction of the reaction time in comparison with the classical synthesis, which requires several hours of heating. Supplemental materials are available for this article. Go to the publisher's online edition of Journal of Carbohydrate Chemistry to view the free supplemental file.
Valsartan Attenuates KIR2.1 by Downregulating the Th1 Immune Response in Rats Following Myocardial Infarction (2015)

Valsartan ameliorates IK1/Kir2.1 remodeling by downregulating the Th1 immune response following MI.
Design and Synthesis of 1,2-Deoxy-pyranose Derivatives of Spliceostatin A toward Prostate Cancer Treatment (2020)

We designed and synthesized a novel 1,2-deoxy-pyranose and terminal epoxide methyl substituted derivatives of spliceostatin A using Julia-Kocienski olefination as a key step. With respect to the biological activity, the 1,2-deoxy-pyranose analogue of spliceostatin A suppressed AR-V7 expression at the nano level (IC<sub>50</sub> = 3.3 nM). In addition, the <i>in vivo</i> toxicity test showed that the 1,2-deoxy-pyranose analogue was able to avoid severe toxicity compared to spliceostatin A.
The Long Spaced Acoustic Logging Tool (1984)

A new and unique long spaced acoustic logging tool has been developed. The tool can record superior quality acoustic data by combining advances in transducer and downhole equipment design with a high speed real-time stacker and digitizer at the surface. The high quality data obtained by the system allows easy analysis of the digitally recorded data for extraction of accurate compressional velocities even when unfavorable hole conditions exist. Examples of these conditions include logs run through permafrost and in gas sands. In addition, when the formation shear velocities are greater than fluid compressional velocity, the digitally recorded data can be analyzed to extract shear velocities from the wave train. The long spacings used by this tool allow the shear wave packet to separate from the compressional energy for easy analysis.
Biochemical Effects of Phosphate-Containing Replacement Fluid for Continuous Venovenous Hemofiltration (2012)

Phoxilium versus Accusol use during CVVH effectively prevented hypophosphatemia but contributed to mild hyperphosphatemia, and is associated with relative hypocalcemia and metabolic acidosis.
Specific induction of <i>gadd45</i> in human melanocytes and melanoma cells after UVB irradiation (2002)

The purpose of our study was to analyze the p53-mediated response of human melanocytes and human melanoma cells to UVB (natural environmental carcinogen) or UVC irradiation (experimental carcinogen). A semi-quantitative RT-PCR method was developed to allow the analysis of the expression of 5 p53 effector genes (p21(WAF1), mdm2, cyclin G1, gadd45, bax) at the same time with a small amount of RNA (1 microg). In human melanocytic cells, the p53 downstream genes were found to be differentially activated after UVB and UVC irradiation. After UVB irradiation, p53 protein accumulation was sustained up to 48 hr that was not the case after UVC irradiation. Among the p53 effector genes tested, gadd45 was the only 1 to show a strong and specific induction after UVB irradiation. With high UVB doses, gadd45 was also the only gene to be transcribed. By contrast, after UVC irradiation, all the p53 effector genes tested were transcriptionally induced. Experiments conducted with fibroblasts and keratinocytes didn't show such a striking activation of gadd45 after UVB irradiation. These results point out the potential role of gadd45 in response to UVB irradiation in human melanocytes and the different p53-mediated responses to different carcinogens.
Development of a new small-scale storage stability test for petroleum fuels (1985)

A new storage stability test has been developed in which 10-ml aliquots of hydrocarbon liquids are aged at 65/sup 0/C in small glass bottles containing nylon membrane filters at the bottom of the bottle. Sediment that forms in the liquid during aging precipitates onto the filter. At the end of the aging period the filter is removed from the bottle, washed with solvent, dried, and weighed to determine the weight of deposited sediment. Materials which are very viscous or even solid at the aging temperature can be tested by dissolving the sample in a solvent. 3 figs., 7 tabs.