gebhart/patrepeval huggingface dataset:
On the role of the CP47 core antenna in the energy transfer and trapping dynamics of Photosystem II (2004)

The CP47–RC complex of photosystem II (PS II) has an antenna subunit of 16 chlorophyll a molecules attached to the reaction center (RC) at the side of its inactive branch. The X-ray structure of PS II revealed that the shortest interpigment distances between CP47 and RC are about 21 Å, which is two-three times larger than within each subunit. Such long distances may slow down the energy transfer from CP47 to RC. In order to evaluate the influence of the CP47 antenna on the energy transfer and trapping dynamics in the RC we performed a comparative analysis of CP47–RC and RC complexes from spinach by transient difference absorption and time-resolved fluorescence spectroscopy at room temperature. Our data reveal a complex multiexponential decay of the excited states in both complexes. The main trapping lifetimes are 2–3, 30–40 and 360–460 ps in the RC and 2–6, 80–85 and 650–700 ps in the CP47–RC, the latter two phases being two to three times longer than in the RC. The data could be fitted well with a kinetic model consisting of three reversible radical pair states, the first one being nearly isoenergetic with P680*, and identical energy levels and kinetics of processes occurring within the RC in both complexes. We conclude that there is no kinetic limitation of the energy transfer between CP47 and RC on the two slowest trapping phases and that this transfer occurs in 20 ps or less. The two factors that influence the observed slower trapping in CP47–RC are the highly reversible charge separation reaction in the RC and the presence in CP47 of states with energy lower than the primary electron donor P680.
A Probabilistic Comparative Study of Various Base Isolation Systems—Nonstationary Earthquake Excitation (1988)

A probabilistic comparative study of various base isolation systems is carried out. The laminated rubber bearing with and without lead plug, the resilient-friction, and the EDF base isolation systems are studied. A nonstationary stochastic model for earthquake ground acceleration is considered. The method of equivalent linearization in conjunction with the moments of the Fokker-Planck equation is used for response analysis. An excitation intensity corresponding to the N00W component of El Centro 1940 earthquake is considered and the root-mean-square displacement and velocity responses of a rigid structure with various base isolation systems are evaluated. Several Monte-Carlo digital simulation studies are also performed. The results are compared with those of the statistical linearization method and good agreements are observed. It is concluded that the friction-type base isolation systems lead to lower mean-square and peak responses.
Development of an in vitro method for modeling drug release and subsequent tissue drug uptake and deposition in a pulsatile flow network (2011)

A novel benchtop model of drug elution and arterial drug deposition following stent implantation has been developed. The model contains a single drug loaded strut and a compartment simulating the vessel wall, housed in a flow chamber under a pulsatile flow regime. Each component has programmable transport properties that can be implemented into a computational model of drug elution. An initial experiment determining the effects of luminal flow on drug deposition patterns was performed. The results show that spatial distribution of drug correlates with areas of low and recirculating flow surrounding the strut. This spatial distribution of drug was shown to be dependent on both transient release behavior and the local flow field surrounding the strut. Furthermore, these results showed that the novel method could be used to study the effects of luminal flow in the presence of single or multiple struts. The method could also be used to explore more complex drug release strategies.
Hydrogenation of β-N-Substituted and β-N,N-Disubstituted Enamino Esters in the Presence of Iridium(I) Catalyst (2009)

International audience
Portable Gentle Jogger Improves Glycemic Indices in Type 2 Diabetic and Healthy Subjects Living at Home: A Pilot Study (2020)

Gentle Jogger is a portable, passive movement technology that reduces physical inactivity while improving 24 hr glycemic control. It can be self-administered as a standalone device or as an adjunct to diabetic medications. This trial is registered with NCT03550105.
A Gene Encoding a Cytochrome <i>c</i> Oxidase‐Like Protein Is Located Closely to the Cytochrome <i>c</i>‐553 Gene in the Anaerobic Bacterium, <i>Desulfovibrio vulgaris</i> (Miyazaki F) (1995)

The gene encoding cytochrome c-553 from Desulfovibrio vulgaris (Miyazaki F) was cloned using a synthetic oligodeoxyribonucleotide probe. The nucleotide sequence indicated that cytochrome c-553 was synthesized as a precursor protein with an NH2-terminal signal sequence of 23 residues. In the cloned DNA fragment, there are three other open reading frames whose products have 191, 157, 541 amino acid residues, respectively. The putative ORF-4 product is highly homologous with the cytochrome c oxidase subunit I from various organisms.
Adaptive Transversal digital Filter for reference current detection in shunt active power filter (2015)

In this paper, an effective closed loop reference current extraction topology for single phase active power filter applications, is proposed. The main idea of the proposed topology is based on the Adaptive Transversal Filter (ATF) principle. The adaptive filter is designed and optimized using genetic algorithm (GA). The proposed methodology is simulated and tested in MatLab software. The results indicate the ability of the method to extract harmonics, inter-harmonics and noise in case of stationary and non-stationary situations. Moreover, it shows a robust detection performance under transient of supply frequency.
Electrooptic Properties of Lead Zirconate Titanate Films Prepared on Silicon Substrate (2006)

The electrooptic (EO) properties of light propagated through lead zirconate titanate (PZT) films prepared on silicon (Si) substrates were successfully evaluated. Polycrystalline, {101}-oriented and {100}-oriented epitaxial PZT films with a thickness of approximately 2 µm were prepared on various types of Si substrate by chemical solution deposition. The anisotropic EO effect was observed in the polycrystalline and {101}-oriented PZT films. The in-plane and out-of-plane refractive indices of the {100}-oriented epitaxial PZT films changed with the type of substrate. The EO effect of the {100}-oriented epitaxial PZT film grown on a Si substrate was found to be more isotropic than those of the polycrystalline and {101}-oriented PZT films. The largest EO coefficients (re=54 pm/V and rc=60 pm/V) were obtained in the {101}-oriented PZT film on the Si substrate.
Mechanism of long-lasting synaptic inhibition in Aplysia neuron R15 (1980)

1. Long-lasting inhibition is a synaptically mediated response found in certain molluscan nerve cells that fire action potentials in bursts. It is elicited by repetitive stimulation of a presynaptic nerve and may last for minutes or hours after stimulation. 2. Voltage-clamp techniques were employed to measure the voltage dependence of the synaptically elicited current. Current-voltage curves were obtained by stepping or sweeping the voltage over the range -40 to -120 mV. 3. Long-lasting inhibition was found to be mediated by two separate conductance mechanisms. A component that reverses near -80 mV is most prominent at times up to 5 min following stimulation. A component with no reversal potential between -40 and -120 mV predominates at later times. 4. The reversible component is attenuated by reducing the intensity of stimulation of the presynaptic nerve, by injection of TEA into the postsynaptic cell, or by activation of a potassium conductance with serotonin prior to stimulation of the nerve. Thus, the reversible component appears to be mediated by an increase in potassium conductance. 5. The effects of the nonreversible component measured in the soma appear to be too large to attribute it to a conductance change that is electrically "distant" from the soma. It is attenuated by turning off a resting inward ion conductance with dopamine prior to stimulation of the nerve. It is not affected by short exposure to ouabain, but is attenuated by longer exposures that reduce the sodium and calcium gradients. Thus, the nonreversible component may be mediated by a decrease in voltage-dependent inward current flow carried by sodium or calcium.
Reservoir Management Tool-Kits in Offshore Khafji Field: Successful Solutions for Field Case Studies on Water Conning Problems in Sandstone Reservoirs (2013)

Abstract A sandstone reservoir (SA) is the main producer reservoir in offshore Khafji oil field. This field has been producing since 1959. However, for time being, some wells suffer from excessive water production especially in old vertical wells. In addition, early water breakthrough in vertical wells is mainly due to high permeability streaks and unfavorable mobility ratio. Therefore, controlling water production is a challenge for reservoir management team work in Khafji Joint Operations (KJO) because there are several different explanations for the water sources in SA sandstone reservoir. These sources could be one or combination of edge water movement and flow behind casing. This phenomena can occur due to high permeability streaks, and conductive channels or/and faults. To sustain the KJO Maximum Sustainable Capacity (MSC), reservoir management in KJO should apply optimum development scenarios for reducing the water production utilizing several and effective water shut-off techniques due to production facility bottlenecks. Converting the old and high water production vertical wells to horizontal and lateral wells which have shown a high rate of success in terms of conducting better technique and scenario to retrieve and bring these wells into production with low water cut. The approaches included also reducing the choke size, cement jobs to shut-in watered out intervals and adding new perforations or re-perforating oil productive intervals. Several successful field cases have been applied in SA reservoir which resulted to high oil production with low water cut. This paper discussed more details of lessons learned and applied techniques to control excessive water production from oil wells and comparison in selecting them for applying optimum applicable techniques. The results of water management techniques and scenarios to retrieve the wells are analyzed and discussed in this study. Reasons for conversion, directions, diagnosis, selected intervals, simulation results analysis, lessons learned, challenges and conclusions were addressed in this paper.
Bridging paradigms: Spatial hypertext in a document world (2001)

Spatial hypertext has arisen from overview “map ” representations of conventional nodeand-link hypertexts (Shipman and Marshall, 1999). These spatial representations (e.g., Streitz et al., 1989; Marshall and Shipman, 1995; Shipman et al., 2001), can be used to model abstract relationships, encoding them using a variety of visual attributes such as
[Pseudoinfarct after placing an epicardial ICD patch electrode: differentiation with SPECT and PET technique]. (1996)

A 64-year-old male who received an implantable cardioverter defibrillator with epicardial patch electrodes in 1990 was admitted to the emergency room because of recurrent defibrillator shocks. During the following diagnostic work-up a remarkable discrepancy between coronary angiography (no significant stenosis), 201Thallium-SPECT imaging (antero-septal persistent defect) and PET imaging (no 18FDG defect) was noticed. In order to assess the impact of the epicardial defibrillator patch electrodes on the imaging, we performed SPECT and PET measurements using a thorax phantom. We found that in 201Tl-SPECT an epicardial patch caused a significant (up to 20%) photon attenuation, which may lead to the phenomenon of "pseudoinfarction". On PET images epicardial patch electrodes failed to produce any significant attenuation artifacts suggestive of infarction.
Management of Kidney Stones in 2020 (2020)

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Inhibition of Tyrosine Kinase Signaling After Trauma-Hemorrhage (2000)

Inhibition of tyrosine kinase signaling after trauma-hemorrhage may represent a novel therapeutic approach for improving organ functions and decreasing the death rate from subsequent sepsis under such conditions.
Turbulent spectral broadening of backscattered acoustic pulses (1974)

The analysis studies the broadening of the frequency spectrum of an acoustic plane-wave pulse backscattered into a finite-angle receiver by the action of a transverse mean wind which moves turbulent velocity and temperature fluctuations through the beam. The results include the frequency spectrum I(k) of the acoustic pressure as a function of wavenumber and the spectral equivalent width b, as a function of mean transverse wind speed and receiver aperture. For broad beams, both temperature and velocity fluctuations contribute to the apparent 180°-backscatter intensity, and the contributing eddy scales vary from λ/2 to λ/√2. Again for broad beams and for typical experimental parameters for atmospheric echosondes, the broadening effects of mean transverse wind in the scattering volume outweigh the broadening effects of turbulence trransported by a mean transverse wind during propagation to the scattering volume. However, as the receiver beam angle decreases, the spectral broadening drops to zero, regardless of mean wind. Figures are included to show the effects of wind broadening for the case of intermediate receiver beam angles.
Synthesis of 1-substituted 5-aryl-3-styryl-2-pyrazolines and 3-aryl-5-styryl-2-pyrazolines by the reaction of dibenzylideneacetones and<i>E,E</i>-cinnamylideneacetophenones with hydrazines (2006)

The reaction of dibenzylideneacetones or E,E-cinnamylidene- acetophenones and hydrazine hydrate provided 1-propionyl derivatives of 5-aryl-3-styryl-2-pyrazolines and 3-aryl-5-styryl-2-pyrazolines. These unsaturated ketones afforded 1-(2-carboxyphenyl) or 1-(4-carboxyphenyl) 5-aryl-3-styryl-2-pyrazolines and 1-(4-carboxyphenyl) derivatives of 3-aryl-5-styryl-2-pyrazolines on treatment with (2-carboxyphenyl)-hydrazine or (4-carboxyphenyl)hydrazine in hot acetic acid. Structures of all new 2-pyrazolines have been elucidated by microanalyses and a combined utilization of various spectroscopic methods.
A coordination perspective on software architecture: towards a design handbook for integrating software components (1996)

This thesis argues that many of the difficulties associated with building software applications by integrating existing components are related to a failure of current programming languages to recognize component interconnection as a separate design problem, orthogonal to the specification and implementation of a component's core function. It proposes SYNOPSIS, an architectural description language which supports two orthogonal abstractions: activities, for representing the functional pieces of an application, and dependencies, for describing their interconnection relationships. Coordination processes, defined as an attribute of dependencies, describe implementations of interconnection protocols. Executable systems can be generated from SYNOPSIS descriptions by successively replacing activities with more specialized versions and managing dependencies with coordination processes, until all elements of the description are specific enough for code generation to take place. Furthermore, it proposes a "design handbook", consisting of a vocabulary of common dependency types and a design space of associated coordination processes. The handbook is based on the insight that many software interconnection relationships can be described using a relatively narrow set of concepts orthogonal to the problem domain of most applications, such as resource flows, resource sharing, and timing dependencies. A prototype component-based application development tool called SYNTHESIS was developed. SYNTHESIS maintains a repository of increasingly specialized dependency types, based on the proposed design handbook. It assists the generation of executable applications by successive semi-automatic transformations of their SYNOPSIS descriptions. A set of four experiments is described. Each experiment consisted in specifying a test application as a SYNOPSIS diagram, associating application activities with components exhibiting various mismatches, and using SYNTHESIS to assemble these components into executable systems. SYNTHESIS was able to exploit its dependencies repository in order to resolve a wide range of interoperability and architectural mismatches and integrate independently developed components into the test applications, with minimal or no need for additional manually-written code. It was able to reuse a single SYNOPSIS architectural description in order to generate versions of a test application for two different execution environments. Finally, it was able to suggest various alternative architectures for integrating each component set into its corresponding application.
Peptic Ulcer Disease and the Risk of Bladder Cancer in a Prospective Study of Male Health Professionals (2004)

Helicobacter pylori is a risk factor for gastric and duodenal ulcers, but gastric ulcers generally occur in individuals who have low acid production and diffuse gastritis, whereas duodenal ulcers are more likely to occur with high acid output and antrum-predominant gastritis. Low acid production, gastritis, and ulcer healing each contribute to poor antioxidant absorption, oxidative stress, and elevated nitrite levels in the stomach. N-Nitrosamines are known carcinogens, and nitrate ingestion has been related to bladder cancer risk. Consequently, we hypothesized that the gastric conditions associated with gastric ulcers may contribute to elevated bladder cancer risk. We thus examined the association between self-reported history of peptic ulcer disease and the risk of bladder cancer (414 cases) over 14 years of follow-up in the Health Professional Follow-Up Study. Cox proportional hazards models were performed to adjust for known risk factors of bladder cancer. Men who reported a gastric ulcer before 1986 had a significantly higher risk of bladder cancer compared with those with no history of gastric ulcer (relative risk = 1.55, 95% confidence interval = 1.03-2.33, controlling for smoking and other potential confounders). No association was observed for duodenal ulcers (multivariate relative risk = 0.97, 95% confidence interval = 0.68-1.38). The ulcers in this study were based solely on self-report and not medical records; consequently, misclassification of ulcers may have occurred. Although intriguing, these findings need to be replicated.
Correction (2004)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Syntheses from 4-Phenyl-2-piperidone<sup>1</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses from 4-Phenyl-2-piperidone1C. F. Koelsch and Robert W. DeNetCite this: J. Am. Chem. Soc. 1953, 75, 13, 3271–3272Publication Date (Print):July 1, 1953Publication History Published online1 May 2002Published inissue 1 July 1953https://doi.org/10.1021/ja01109a505RIGHTS & PERMISSIONSArticle Views104Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (286 KB) Get e-Alerts Get e-Alerts
HVAC Ventilation Strategies: The Contribution for Thermal Comfort, Energy Efficiency, and Indoor Air Quality (2007)

Abstract In Heating Ventilating and Air Conditioning (HVAC) systems, ventilation strategies impact building energy consumption, occupants' thermal comfort and Indoor Air Quality (IAQ). Ventilation strategies such as Mixing Jet Ventilation (MJV), Displacement Ventilation (DV), and Impinging Jet Ventilation (IJV) are operated on the different principals. MJV relies on dilution, while DV and IJV rely on both dilution and stratification. Due to climatic variation, ventilation strategies must be operated under different cooling and heating load scenarios. Typically, each ventilation strategy controls the indoor environment through a single adequate flow rate with suitable supply parameters such as temperature, pollutant concentration, vapor, velocity, etc. Hence, the indoor thermal and IAQ condition are independently impacted. A room with excellent thermal condition is possible to have poor IAQ. Given this limitation, vast air flow variables, and occupants' activities, the performances evaluation of these strategies are complicated. In this study, three ventilation strategies, MJV, DV, and IJV are thoroughly investigated. The Computational Fluid Dynamics (CFD) simulation was mainly utilized to handle the complexity of this study. The parametric studies of 48 CFD simulations are presented. Referring to ASHRAE RP-1133, the experimental data from a specially built HVAC-IEQ laboratory was used to validate the CFD data. The research results indicate both advantages and disadvantages in all three strategies. In addition, there is no single strategy that can perform excellently in all indexes. Using the well-known index called ventilation effectiveness (VEF), DV performs outstandingly. However, under a newly proposed index called ventilation performances, DV fails because the stratification discomfort exceeds 36% of room area. MJV suffers from low VEF and excessive draft. However, the IAQ of MJV is not as poor as expected. IJV can be an alternative especially for space where sleeping and sitting activities dominate. IJV can conserve HVAC energy, while maintaining good IAQ. Compared to DV, although VEF is lower, stratification discomfort is minimized to 24%–12% (depending on supply velocity). Overall, this study demonstrates that ventilation strategies are the key to enhance IAQ. Therefore, the utilization of an appropriate ventilation strategy might increase, Leadership in Energy and Environmental Design (LEED) score, particularly for Indoor Environmental Quality, Innovation and Design Process, and Energy and Atmospheric categories.