gebhart/patrepeval huggingface dataset:
Ornithine decarboxylase activity in insulin-deficient states (1980)

The activity of ornithine decarboxylase, the rate-controlling enzyme in polyamine biosynthesis, was determined in tissues of normal control rats and rats made diabetic with streptozotocin. In untreated diabetic rats fed ad libitum, ornithine decarboxylase activity was markedly diminished in liver, skeletal muscle, heart and thymus. Ornithine decarboxylase was not diminished in a comparable group of diabetic rats maintained on insulin. Starvation for 48h decreased ornithine decarboxylase activity to very low values in tissues of both normal and diabetic rats. In the normal group, refeeding caused a biphasic increase in liver ornithine decarboxylase; there was a 20-fold increase in activity at 3h followed by a decrease in activity, and a second peak between 9 and 24h. Increases in ornithine decarboxylase in skeletal muscle, heart and thymus were not evident until after 24-48h of refeeding, and only a single increase occurred. The increase in liver ornithine decarboxylase in diabetic rats was greater than in normal rats after 3h of refeeding, but there was no second peak. In peripheral tissues, the increase in ornithine decarboxylase with refeeding was diminished. Skeletal-muscle ornithine decarboxylase is induced more rapidly when meal-fed rats are refed after a period without food. Refeeding these rats after a 48h period without food caused a 5-fold increase in ornithine decarboxylase in skeletal muscle at 3h in control rats but failed to increase activity in diabetic rats. When insulin was administered alone or together with food to the diabetic rats, muscle ornithine decarboxylase increased to activities even higher than in the refed controls. In conclusion, these findings indicate that the regulation of ornithine decarboxylase in many tissues is grossly impaired in diabetes and starvation. They also suggest that polyamine formation in vivo is an integral component of the growth-promoting effect of insulin or some factor dependent on insulin.
Identification of a PDGF-responsive element in the murine c-myc gene. (1990)

The c-myc gene is rapidly induced in quiescent Balb/c-3T3 cells in response to the platelet-derived growth factor (PDGF). In order to study the mechanisms by which growth factors regulate induction of c-myc, we have attempted to identify growth factor-responsive elements in the murine c-myc locus. Various fragments of the c-myc gene linked to a bacterial CAT reporter gene were stably transfected into Balb/c-3T3 cells. A construct which includes the P1 promoter and 424 bp of upstream sequences shows a 3-5 fold induction of CAT RNA expression in response to sis/PDGF. S1 nuclease mapping experiments demonstrate that this mRNA initiates from the myc P1 promoter. Nuclear runoff transcription experiments performed with this myc/CAT construct show that this induction occurs at the transcriptional level. Deletion analysis led to the identification of an 81 bp segment in the first exon between the c-myc P1 and P2 promoters which is necessary to confer growth factor responsiveness in this construct.
Process Upsets Involving Trace Contaminant Control Systems (2000)

<div class="htmlview paragraph">Paradoxically, trace contaminant control systems that suffer unexpected upsets and malfunctions can release hazardous gaseous contaminants into a spacecraft cabin atmosphere causing potentially serious toxicological problems. Trace contaminant control systems designed for spaceflight typically employ a combination of adsorption beds and catalytic oxidation reactors to remove organic and inorganic trace contaminants from the cabin atmosphere. Interestingly, the same design features and attributes which make these systems so effective for purifying a spacecraft’s atmosphere can also make them susceptible to system upsets. Cabin conditions can be contributing causes of phenomena such as adsorbent “rollover” and catalyst poisoning can alter a system’s performance and in some instances release contamination into the cabin. Evidence of these phenomena has been observed both in flight and during ground-based tests. The following discussion describes specific instances of system upsets found in trace contaminant control systems, groups these specific upsets into general hazard classifications, and recommends ways to minimize these hazards.</div>
Green orthoclase feldspar from Vietnam (2005)

In July 2005,\nthese contributors received some interesting transparent\n"emerald" green samples that were reported to be amazonite\nfrom a new find in Vietnam. Five faceted stones\nwere loaned and several pieces of rough were donated to\nGIA by Bill Larson (Pala International, Fallbrook,\nCalifornia). According to his supplier, Son T. Ta (I.T.C.\nInternational Trade Center, Ho Chi Minh City, Vietnam),\nthey were mined from a pegmatite near Minh Tien, about\n15 km south of Luc Yen in Yen Bai Province. This area is\nalso known to produce transparent green fluorite, which\nwhen cobbed is similar in appearance to gem-quality\northoclase.
Chemical and enzymatic modification of sophorolipids (2015)

This review focuses on the chemical and enzymatic modification of sophorolipid biosurfactants into new derivatives.
A first approach to filament dynamics (2010)

Modelling elastic filament dynamics is a topic of high interest due to the wide range of applications. However, it has reached a high level of complexity in the literature, making it unaccessible to a beginner. In this paper we explain the main steps involved in the computational modelling of the dynamics of an elastic filament. We first derive equations governing the dynamics of an elastic lament suitable for a computer simulation implementation. The derivation starts from the relation between forces and potential energy in conservative systems in order to derive the equation of motion of any bead in the filament. Only two-dimensional movements are considered, but extensions to three dimensions can follow similar lines. Suggestions for computer implementations are provided in Matlab as well as an example of application related to the generation of musical sounds. This example allows a critical analysis of the numerical results obtained using a cross-disciplinary perspective. Since derivations start from basic physics equations, use simple calculus and computational implementations are straightforward, this paper proposes a different approach to introduce simple molecular dynamics simulations or animations of real systems in undergraduate elasticity or computer modelling courses.
Slowed reaction time in asymptomatic HIV-positive patients (1992)

A total of 24 asymptomatic HIV-infected patients (CDC II/III) and 27 HIV-negative controls were tested for speed of reaction and for general neuropsychological functioning. Reaction time was assessed with two computerized tests with differing levels of cognitive complexity. The results show that the asymptomatic HIV-positive patients have a significantly longer mean reaction time to simple and complex stimuli (SRT p < 0.001, CPT p < 0.05), and a significantly greater standard deviation (SD) (SRT-SD p < 0.005). No significant differences were observed on any of the clinical neuropsychological tests, or in the number of false positive (FP) or non-responses to stimuli (NR) from the CPT. The results indicate that asymptomatic HIV-infected patients are slower and have a greater intra-subject variability in speed using a simple test for reaction time. The difference is less pronounced when doing a more demanding cognitive task and not significant in a test of visuo-motor coordination or on other clinical neuropsychological tests. Emotional state or cognitive strategies affecting speed/accuracy trade-off do not account for the findings.
The relativistic transformation of the energy and momentum of a gas (1977)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation M. G. Calkin, M. H. Jericho; The relativistic transformation of the energy and momentum of a gas. Am. J. Phys. 1 December 1977; 45 (12): 1224. https://doi.org/10.1119/1.10686 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAmerican Association of Physics TeachersAmerican Journal of Physics Search Advanced Search |Citation Search
Diabetes-induced Central Neuritic Dystrophy and Cognitive Deficits Are Associated with the Formation of Oligomeric Reticulon-3 via Oxidative Stress (2013)

Diabetes is a high risk factor to dementia. To investigate the molecular mechanism of diabetic dementia, we induced type 2 diabetes in rats and examined potential changes in their cognitive functions and the neural morphology of the brains. We found that the diabetic rats with an impairment of spatial learning and memory showed the occurrence of RTN3-immunoreactive dystrophic neurites in the cortex. Biochemical examinations revealed the increase of a high molecular weight form of RTN3 (HW-RTN3) in diabetic brains. The corresponding decrease of monomeric RTN3 was correlated with the reduction of its inhibitory effects on the activity of β-secretase (BACE1), a key enzyme for generation of β-amyloid peptides. The results from immunoprecipitation combined with protein carbonyl detection showed that carbonylated RTN3 was significantly higher in cortical tissues of diabetic rats compared with control rats, indicating that diabetes-induced oxidative stress led to RTN3 oxidative damage. In neuroblastoma SH-SY5Y cells, high glucose and/or H2O2 treatment significantly increased the amounts of carbonylated proteins and HW-RTN3, whereas monomeric RTN3 was reduced. Hence, we conclude that diabetes-induced cognitive deficits and central neuritic dystrophy are correlated with the formation of aggregated RTN3 via oxidative stress. We provided the first evidence that oxidative damage caused the formation of toxic RTN3 aggregates, which participated in the pathogenesis of central neuritic dystrophy in diabetic brain. Present findings may offer a new therapeutic strategy to prevent or reduce diabetic dementia.
Targeted matrix completion (2017)

Matrix completion is a problem that arises in many data-analysis settings where the input consists of a partially-observed matrix (e.g., recommender systems, traffic matrix analysis etc.). Classical approaches to matrix completion assume that the input partially-observed matrix is low rank. The success of these methods depends on the number of observed entries and the rank of the matrix; the larger the rank, the more entries need to be observed in order to accurately complete the matrix. In this paper, we deal with matrices that are not necessarily low rank themselves, but rather they contain low-rank submatrices. We propose Targeted, which is a general framework for completing such matrices. In this framework, we first extract the low-rank submatrices and then apply a matrix-completion algorithm to these low-rank submatrices as well as the remainder matrix separately. Although for the completion itself we use state-of-the-art completion methods, our results demonstrate that Targeted achieves significantly smaller reconstruction errors than other classical matrix-completion methods. One of the key technical contributions of the paper lies in the identification of the low-rank submatrices from the input partially-observed matrices.
Modelling attacks and challenges to wireless networks (2012)

Due to the tremendous potential of MANETs (mobile ad hoc networks) for deployment in commercial and military services, a thorough understanding of network behaviour when exposed to challenges is essential for constructing a resilient and survivable MANET. Therefore, it is vital to have a comprehensive framework that can model it under various network attacks and challenges. The MANET environment has a dynamic and intermittent connectivity resulting from channel fading and mobility of the nodes, which makes it difficult to model the network as well as its challenges. We provide a model to simulate malicious and area-based challenges to wireless networks. In the modelling of malicious attacks, we treat MANETs as time-varying graphs (TVGs) represented as a weighted adjacency matrix, in which the weights refer to the link availability. We evaluate the relations between node significance and weighted centrality metrics. Area-based challenges representative of real-world scenarios are also modelled. Our ultimate goal is to provide a comprehensive network challenge model of MANETs and also heterogeneous networks.
Orthogonal Tree Codes for Communication in the Presence of White Gaussian Noise (1967)

This paper describes a convolutional encoder for generating tree codes whose distinct codewords are orthogonal over the constraint length of the code. The performance of this class of codes is analyzed and the error probability is shown to decrease exponentially with the energy-to-noise ratio over the constraint length period of the code. The performance is compared with wellknown results for orthogonal block codes and shown to be considerably superior to the latter. Asymptotic results are also obtained which coincide with results for the class of very noisy memoryless channels.
Differential diagnosis of skin lesions after allogeneic haematopoietic stem cell transplantation (2003)

Allogeneic haematopoietic stem cell transplantation (i.e. bone marrow or peripheral blood stem cell transplantation) is a common procedure in the treatment of various haematological disorders such as aplastic anaemia, (pre)leukaemias, some malignant lymphomas, multiple myeloma and immunodeficiency states. Many of these patients develop erythematous skin lesions following transplantation. Although graft- versus-host disease is the major differential diagnosis in these situations, many other causes of erythema are encountered. The large number of transplant patients means that more and more pathologists are confronted with the challenging problem of making a correct diagnosis in these situations. In this review article we therefore describe the different causes of erythema and their differential diagnoses. In most cases the clinical presentation is related to the microscopical features. Besides acute and chronic graft-versus-host disease, we discuss the (common) drug reactions and non-specific features such as Sweet's syndrome, erythema nodosum and eosinophilic folliculitis. In addition, we deal with the recurrence of original diseases and infections. With this knowledge every pathologist should feel comfortable when looking at skin biopsies of patients after haematological stem cell transplantation.
Increase in the flux-pinning energy of YBa2Cu3O7−δ by shock compaction (1990)

Magnetic flux relaxation data on a composite specimen of YBa2Cu3O7−δ +Ag shock compacted at 167 kbar show that the flux-pinning energy at 70 K and 10 kOe is enhanced by a factor of 2–3. This enhancement persists after annealing at 890 °C in oxygen for 24 h. The increased pinning energy is apparently caused by shock-induced 〈100〉 and 〈110〉 line defects having a density up to 1012 cm−2. Annealing replaces line defects with (001) extrinsic stacking faults having displacement vectors of 1/6[031]. The average separation of the stacking faults in the [001] direction is 0.04 μm, which is comparable to the separation between fluxoids at 10 kOe. These results indicate that intragranular critical current densities can be increased significantly in bulk materials by shock processing. High densities of flux-pinning sites could be induced efficiently in industrial-scale quantities of bulk high Tc oxides by explosives.
Idiotypic vaccination against human B-cell lymphoma. Rescue of variable region gene sequences from biopsy material for assembly as single-chain Fv personal vaccines (1994)

Idiotypic determinants on neoplastic B cells could provide tumor antigens for vaccination of patients with B-cell tumors. Because this approach requires an individual vaccine for each patient, simple methods for obtaining idiotypic antigen are desirable. Using polymerase chain reaction (PCR) with family-based V-gene and J-region primers, the variable region genes of heavy and light chains (VH and VL) of Ig have been obtained from biopsy material from 13 patients with B-cell tumors. In each case, analysis of random clones derived from the PCR product showed repeated, clonally-related sequences, whereas normal lymphoid tissue generated no repeated sequences. In 3/3 cases, the repeated sequences were found to be the same as those in a tumor-derived hybridoma. Mutational patterns in the V-genes differed among the tumors, with follicular lymphoma tending to be more highly mutated. The individual VH and VL sequences have been assembled with a flexible linker sequence to encode single-chain Fv (scFv). The scFv sequences can be cloned into bacterial expression vectors to produce protein, or into vectors suitable for direct vaccination using naked DNA. In a model system, expressed scFv protein retained all idiotypic determinants defined by a panel of five anti-idiotypic monoclonal antibodies (MoAbs). Similarly, expressed scFv proteins from two patients were shown to react with anti-idiotypic antibodies. This approach allows production of potential vaccines from surgical biopsies within 2 to 3 weeks.
Phthalocyanines of a Novel Structure: Dinaphthotetraazaporphyrins with D2h Symmetry (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhthalocyanines of a Novel Structure: Dinaphthotetraazaporphyrins with D2h SymmetryNagao Kobayashi, Tohru Ashida, Tetsuo Osa, and Hideo KonamiCite this: Inorg. Chem. 1994, 33, 9, 1735–1740Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ic00087a003https://doi.org/10.1021/ic00087a003research-articleACS PublicationsRequest reuse permissionsArticle Views266Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Standardization of apolipoprotein B and A-I measurements. (1989)

Abstract Apolipoprotein B, the major protein of low-density lipoprotein, and apolipoprotein A-I, the major protein of high-density lipoprotein, can serve as important predictors of atherosclerotic cardiovascular disease. However, these apolipoprotein measurements have not realized their full potential because of inadequate standardization. Purified apolipoprotein A-I of known absolute mass, in lyophilized form, can serve as primary standard for apolipoprotein A-I, and freshly isolated low-density lipoprotein of narrow density range can serve as primary standard for apolipoprotein B. These primary standards can be used to assign target values to secondary reference material and calibrators by reference laboratories using standardized, validated immunoassay procedures. Lyophilized serum can serve as secondary reference material for apolipoprotein A-I. Freshly frozen serum pools should be used as reference material for apolipoprotein B until more practicable materials that do not exhibit matrix interactions are developed. Implementation of proper standardization procedures can lead to significant improvements in apolipoprotein measurements.
Serodiagnosis of Mycobacterium bovis infection in badgers: development of an indirect ELISA using a 25 kDa antigen (1994)

A 25 kDa antigen of Mycobacterium bovis has previously been identified as immunodominant during badger infections. This 25 kDa antigen was partially purified from sonicated M bovis bacilli by using water precipitation and ion exchange chromatography, and its purification was monitored with a mouse monoclonal antibody, MBS43, which was specific for the antigen. The partly purified antigen was used to develop an ELISA for the assay of badger sera for the presence of specific antibodies. A presumed negative badger population was used to calculate the assay's threshold of seropositivity and using this value, its sensitivity (37 percent) and specificity (98 percent) were determined in a second population of known culture status. The results indicate that it may be possible to develop a specific and cost effective serological field assay for the diagnosis of M bovis infection in living badgers.
Large error recovery for a class of frequency tracking algorithms (1998)

The performance of a recently proposed high-order adaptive notch filter (HANF) for frequency estimation and tracking is studied. An analysis technique utilizing approximations with linear filters is employed to derive closed-form performance expressions for a noisy sinusoidal input signal. Important performance measures, such as stability, noise rejection, statistical efficiency, and tracking ability, are studied in detail, and rules for the design variables are given. A study is presented where the performance of HANF is compared with the performance of a minimal order adaptive notch filter (ANF), as well as with a frequency tracker based on least squares-modelling—the multiple frequency tracker (MFT). The study reveals that HANF is a competitive alternative to ANF, but also that, in general, the MFT is the method of choice. © 1998 John Wiley & Sons, Ltd.