gebhart/patrepeval huggingface dataset:
Denatured Collagen from the Cuticle of Ascaris lumbricoides as a Substrate for Protocollagen Proline Hydroxylase (1968)

Abstract Recent studies have shown that the hydroxyproline and hydroxylysine found in the collagen of vertebrates are synthesized by the hydroxylation of proline and lysine, which have been incorporated into a large polypeptide precursor of collagen called protocollagen. Because the collagen isolated from the cuticle of Ascaris lumbricoides contains less hydroxyproline and hydroxylysine than any other known collagen, it was of interest to determine whether this collagen could serve as a substrate for the synthesis of hydroxyproline by protocollagen proline hydroxylase from a vertebrate source. Essentially no synthesis of hydroxyproline was observed when the hydroxylase from chick embryos was incubated with native cuticle collagen solubilized by either 0.5 m NaCl extraction or pepsin treatment. Both of these large aggregate forms of the collagen, however, served as substrates for hydroxyproline synthesis after they were denatured by heating at 100° for 10 min. A subunit form of the collagen with a lower specific optical rotation than the large aggregate preparations served as a substrate without prior heat treatment, but the rate of hydroxyproline synthesis was increased by boiling the preparation. Comparison of the relative substrate activities and specific optical rotations of various forms of the cuticle collagen indicated an inverse relationship between the rate of hydroxyproline synthesis and the apparent degree of helicity. Previous reports by others have suggested that the subunit structure of collagen from Ascaris cuticle may involve a helical conformation different from that found in other collagens, and it is possible that an unusual conformation of the polypeptide chain or chains of the native cuticle collagen may explain its inability to serve as a substrate for protocollagen proline hydroxylase.
Visual and Chemical Release of Feeding Behavior in Adult Rainbow Trout (1997)

Feeding behavior of adult rainbow trout (Oncorhynchus mykiss) is released by visual and/or chemical stimuli. Detection of either a conditioned visual or a conditioned chemical stimulus creates an excitatory feeding state within the central nervous system which turns on feeding behavior composed of swimming, turning and biting/snapping actions. Particular amino acids that are highly effective physiological taste stimuli that are also detected through olfaction (e.g. L-proline, L-alanine, L-leucine) release the initial sequence of food searching and biting/snapping behaviors; however, an effective olfactory, but poor gustatory, stimulus (e.g. L-arginine) is rarely effective behaviorally. After bilateral removal of the paired olfactory organs, visual stimuli alone release the entire set of feeding behavior patterns. Since amino acids that are highly potent physiological taste stimuli do not release either feeding behavior or reflex biting/snapping actions in adult anosmic rainbow trout, it is postulated that the olfactory system detects potent taste stimuli and provides the afferent input for arousal and the release of all feeding activity patterns.
Design and Development of a New Automated and High Speed Cap Sealing System (2011)

Plastic welding is a technical process of welding plastic component together and it is one of the primary processes of joining plastics. There are several types of techniques in the plastic welding including hot gas welding, extrusion welding, contact welding, hot plate welding, injection welding, and friction welding, To increase the plastic welding speed and sealing capacity, this research introduces a new automated and high speed cap sealing system applied to cartridge filled with gas product. The computer-aided modeling analysis and prototype testing show that this automated and high speed welding system has high production rate, good sealing quality, reliable function, and cost-effective manufacturing process.
Preventing Damage by Hidden Objects in Vegetation (2006)

The paper presents the experimental radar-based sensor to operate in environment with vegetation cover for detection and discrimination there the small-sized invisible dielectric and metallic objects. This sensor constitutes a vehicle-housed emergency system for surveillance of area with vegetation ahead on the path of moving vehicle to prevent its contact with hidden objects. The emergency system functioning in basically implemented by real-time electromagnetic imaging of the scene of interest and its following image processing to enhance the target responses. The developed and tested experimental radar techniques are under consideration. The results of experimental examinations in field are presented and discussed.
Expression of Fas ligand in patients with evident skull base involvement of nasopharyngeal carcinoma (2002)

We investigated whether skull base involvement in patients with nasopharyngeal carcinoma (NPC) is correlated with expression of Fas ligand (FasL) in NPC cells. A prospective assessment of FasL expression was determined by immunohistochemistry and in situ hybridization in 98 patients with newly diagnosed NPC. Among these patients, 21 had evident skull base involvement. Expressions of human apoptosis-related genes and FasL were confirmed by reverse transcription-polymerase chain reaction. Relation between the frequency of skull base involvement and FasL expression was analyzed by Chi-square and multivariate analyses. FasL expression was detected in 32 (32.6%) of 98 pathological sections. Compared to patients with low FasL expression in tumors, patients with notable FasL expression had higher incidence of skull base involvement (28.6 vs. 71.4%, p<0.005). Expression of FasL in tumor cells was correlated with the higher frequency of skull base involvement in patients with NPC.
ChemInform Abstract: Selective Alkylations of 1,2,4‐Triazole and Benzotriazole in the Absence of Solvent. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Experimental Demonstration of Optical Wave Propagation in PT-Symmetric Potentials (2009)

Wave propagation in parity-time symmetric potentials is studied for the first time in systems involving a complex refractive index distribution with gain/loss. We demonstrate experimental results for an optically-pumped directional coupler in photorefractive LiNbO3.
Chemically oxidized polypyrrole: Influence of the experimental conditions on its electrical conductivity and morphology (1995)

Abstract The effect of synthesis conditions on the electrical conductivity and the morphology of a chemically oxidized polypyrrole was investigated. It was found that the electrical conductivity of polypyrrole was strongly dependent on the pyrrole/FeCl 3 ratio, which controls the redox potential of the reaction medium. The reaction temperature and the reaction duration also influence the electrical conductivity of the polypyrrole. A considerable influence of the nature of the solvent used on the aggregation state of polypyrrole particles was demonstrated. Optimal experimental conditions are proposed.
Role of host tRNAs and aminoacyl-tRNA synthetases in retroviral replication (2019)

The lifecycle of retroviruses and retrotransposons includes a reverse transcription step, wherein dsDNA is synthesized from genomic RNA for subsequent insertion into the host genome. Retroviruses and retrotransposons commonly appropriate major components of the host cell translational machinery, including cellular tRNAs, which are exploited as reverse transcription primers. Nonpriming functions of tRNAs have also been proposed, such as in HIV-1 virion assembly, and tRNA-derived fragments may also be involved in retrovirus and retrotransposon replication. Moreover, host cellular proteins regulate retroviral replication by binding to tRNAs and thereby affecting various steps in the viral lifecycle. For example, in some cases, tRNA primer selection is facilitated by cognate aminoacyl-tRNA synthetases (ARSs), which bind tRNAs and ligate them to their corresponding amino acids, but also have many known nontranslational functions. Multi-omic studies have revealed that ARSs interact with both viral proteins and RNAs and potentially regulate retroviral replication. Here, we review the currently known roles of tRNAs and their derivatives in retroviral and retrotransposon replication and shed light on the roles of tRNA-binding proteins such as ARSs in this process.
Distribution Studies with Bovine Plasma Albumin<sup>1</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDistribution Studies with Bovine Plasma Albumin1T. P. King, D. A. Yphantis, and L. C. CraigCite this: J. Am. Chem. Soc. 1960, 82, 13, 3350–3355Publication Date (Print):July 1, 1960Publication History Published online1 May 2002Published inissue 1 July 1960https://pubs.acs.org/doi/10.1021/ja01498a030https://doi.org/10.1021/ja01498a030research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Master/Slave assignment optimization for high performance computing in an EC2 cloud using MPI (2012)

For high performance computing, cloud services offer highly scaleable infrastructures on demand. Without requiring a great deal of maintenance and financial resources, which a datacenter would need, it is possible to obtain a huge set of computing instances from, e.g., the Amazon Elastic Computing Cloud (Amazon EC2). The downsides of cloud computing are that the set of computing instances is arbitrary and that communication speed varies greartly and affects the running time of algorithms. We present a master/slave selection algorithm for the EC2 cloud service based on a benchmark to counteract this disadvantage. The benchmark measures communication speed and the variance of communication in a NxN network consisting of N cloud instances. With the results of the benchmark, we perform a master/slave selection algorithm to maximize the number of messages between master and slaves. The results show that our proposed method greatly increases efficiency.
[IC‐P‐018]: NEUROIMAGING‐DEFINED AMYLOID AND CEREBROVASCULAR PATHOLOGY ARE ASSOCIATED WITH A NEUROMETABOLIC SIGNATURE OF ALZHEIMER's DISEASE (2017)

To investigate whether white matter hyperintensities (WMH), an MRI-correlate of small-vessel cerebrovascular disease, are associated with a neurometabolic signature of Alzheimer's disease (AD), defined as the metabolic correlates of preclinical ß-amyloid (Aß) pathology and the apolipoprotein-E ε4 allele (APOE-ε4), the major genetic risk factor for sporadic AD. Cognitively normal participants (n=30, age=70±5.6 years, MMSE=29.2±1) received 11C-PiB-PET to quantify Aß, 7 Tesla fluid-attenuated inversion recovery MRI to quantitate WMH, and 7 Tesla high-resolution MR spectroscopic imaging to estimate N-acetylaspartate (NAA), myo-inositol (mI), total-choline (tCho), and creatine (Cr) in posterior cingulate and precuneus (PCP) gray and white matter. We examined relationships of Aß, WMH, and APOE-ε4, and their interactions, with brain metabolites. Higher levels of Aß (r= -0.64, p<0.001) and higher WMH volume (r= -0.45, p=0.02) were associated with lower NAA/mI in gray matter. Participants with both high Aß and high WMH had lower NAA/mI compared to those with none or with high level of either Aß or WMH (significant Aß x WMH interaction; F=5.38, p=0.03). APOE-ε4 carriers had lower NAA/mI compared to non-carriers (t=2.24, p=0.03). tCho/Cr in white matter was associated with Aß (r= -0.53 p=0.004) and WMH (r= -0.51; p=0.006); APOE-ε4 carriers with high WMH showed strongest reductions of tCho/Cr (significant APOE-ε4 x WMH interaction, F=6.45, p=0.02). These findings suggest that a neurometabolic signature of AD, defined by metabolic correlates of Aß and APOE-ε4 in older adults, consists of reduced NAA/mI in gray matter and reduced tCho/Cr in white matter. We speculate that these metabolic differences reflect neuronal impairment, glial activation, and altered choline metabolism. This neurometabolic signature of AD is also associated with WMH, both independently and synergistically with Aß and APOE-ε4, emphasizing the importance of small-vessel cerebrovascular disease for AD pathogenesis.
Abstract 1560: VE-PTP inhibitor AKB-9778 mitigates IL-2-induced VLS and interacts positively with IL-2 against melanoma and renal cancer tumors in mice (2010)

Abstract IL-2 induces complete responses (CR) durable more than 10 years in a subpopulation of patients with advanced melanoma or renal cell carcinoma, establishing the clinical effectiveness of immunotherapy for human malignancies. However, the application and clinical efficacy of IL-2 have been limited by its major dose-limiting toxicity vascular leak syndrome (VLS), which occurs in the majority (∼65%) of the patients and often necessitates cessation of the cytokine treatment. Being a life-threatening toxicity, VLS is managed by supportive care with no specific treatment. Therapeutics for IL-2-induced VLS might improve the efficacy and tolerance of the cytokine. Recent studies implicated heightened Ang2 as a potential mediator of VLS via antagonizing Ang1 and thus blocking Tie2/AKT signaling in endothelial cells. Being a regulator of Tie2 phosphorylation, vascular endothelial protein tyrosine phosphatase (VE-PTP) might be targeted to modulate Tie2/AKT signaling although tthe effects and tolerance of targeting VE-PTP were not well-defined. Our work herein identified compound AKB-9778 as a VE-PTP inhibitor capable of inducing pTie2 and down stream pAKT in endothelial cells, interacting positively with Ang1 and/or Ang2 to increase cellular pTie2 levels, reducing IL-2-induced circulating Ang2 in mice and protecting mice from IL-2-induced VLS. AKB-9778 also interacted positively with IL-2 against B16 melanoma and Renca renal cancer tumors in mice in a tolerated manner. These data provide pre-clinical proof of concept evidence of targeting VE-PTP to mitigate IL-2-induced VLS. AKB-9778 may provide beneficial adjunctive therapy in combination with IL-2 in cancer treatment by reducing VLS and enhancing efficacy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1560.
Comparing the Effectiveness of Mentalization-Based Therapy and Cognitive-Analytic Therapy on Ego Strength and Defense Mechanisms in People With Borderline Personality Disorder (2019)

Aims Mentalization-Based Therapy (MBT) and Cognitive Analytic Therapy (CAT) are psychotherapy approaches offering specific methods for the treatment of Borderline Personality Disorder (BPD). Therefore, this study compared the effectiveness of MBT and CAT on improving the ego strength and defense mechanisms in people with BPD. Methods & Materials This was a quasi-experimental study with a pretest-posttest and a control group design and follow-up stage. In total, 40 men with BPD were selected by purposive sampling technique. The samples were selected from males admitted to Isar psychiatric Hospital and the psychiatric department of Fatemi Hospital in Ardabil City, Iran, in 2018. The samples were randomly assigned into two experimental groups and one control group. The first experimental group received 20 sessions of MBT, and the second experimental group received 16 sessions of CAT. To collect data, we used psychological inventory ego strength and defense styles questionnaire. The obtained data were analyzed using mixed model Analysis of Variance (ANOVA) and Scheffe posthoc test. Findings The collected results suggested that both interventions were effective in improving the ego strength and defense mechanisms of people with BPD (P<0.001). However, the effect of MBT on the overall score of the ego strength and the immature defenses was higher than that of the other intervention (P<0.05). Moreover, there was no significant difference in neurotic defense between the two interventions (P>0.05). Conclusion The present research results can support the use of these therapies as part of a non-pharmaceutical treatment program in different treatment centers or psychiatric hospitals.
High-dose cytosine arabinoside and daunorubicin as consolidation therapy for acute nonlymphocytic leukemia in first remission: a pilot study (1985)

High-dose (HD) cytosine arabinoside (ARA-C) is more effective treatment than conventional-dose ARA-C regimens for patients with relapsed acute nonlymphocytic leukemia (ANLL). We report here that HD ARA-C given during the first remission of ANLL has resulted in long remission durations and a high proportion of patients who survive more than three years free of disease. From August 1979 to September 1983, 36 adult patients with ANLL in first remission received one to three courses of HD ARA-C (3 g/m2 by one-hour infusion every 12 hours for 12 doses on days 1 through 6) alone or with daunorubicin (30 mg/m2 for two or three doses on days 7 through 9). Three patients died of sepsis or hemorrhage during consolidation, and 14 patients have relapsed from five to 48 months after diagnosis. The remaining 19 patients are in continued complete remission (CCR) from 11 to 62 months. Denoting all deaths in remission as relapse, the actuarial probability of CCR is 42% at 62 months, with an apparent plateau in the survival curve. Of the first 22 patients treated, ten remain in CCR from 37 to 62 months with no therapy for at least three years. Due to its heightened anti-leukemic activity, HD ARA-C allows brief but effective consolidation of ANLL in first remission, with long-term disease-free survival comparable to other approaches.
Scalable environmental sounds analysis (2009)

This paper describes a method for environmental audio events analysis. The audio events are modeled using a common universal codebook. The codebook is based on the bag-of-frames (BOF). The features corresponding to the frames and extracted from all audio files are grouped into clusters using the k-means algorithm. The individual audio file is modeled on the normalized distribution of the numbers of cluster bins corresponding to the frames of this file. Each audio file is described by one vector. The audio data are represented as feature-file matrix similar to term-document representation in latent semantic indexing (LSI). The LSI is applied to the feature-file matrix to represent the data in latent semantic space. Then the primary file description is converted to the vectors of similarity to anchor reference data. For anchor reference the training data are used. Each component of this vector is a probabilistic similarity between target file and anchor reference file corresponding to the considered component. The LSI is applied once more to the new feature-file matrix, mapping the data to the latent semantic space in the anchor reference space. For audio recognition and audio retrieval the nearest-neighbor (NN) algorithm is exploited. The described data representation improves the results of audio retrieval and recognition.
Theory of jets from young stars (1993)

Simple equations are derived for the long-distance propagation of magnetohydrodynamic (MHD) jets. Solutions of these equations are fitted to two observed jets providing estimates of the fast magnetosonic speeds (V(f)) and the distances of the fast magnetosonic points. The relation of the jet properties at large distances to a complete family of MHD jet solutions is discussed, and it is shown that there is one key dimensionless parameter, B. The dependences of the fast magnetosonic speed and of the fluxes of mass, energy, momentum, and angular momentum of the jet on B are discussed. For B larger than a critical value (about 0.45), the central star spins down, while for smaller values it spins up. For increasing from the critical value, V(f) increases while the mass and momentum fluxes of the jet decrease.
Who will attend tests for the early detection of breast cancer? (1994)

Abstract The purpose was to construct a questionnaire for predicting which women would undergo screening for the early detection of breast cancer. The study was done in the theoretical framework of the cognitive orientation (CO) theory (Kreitler & Kreitler, 1976) that shows how cognitive contents guide behaviors. A CO questionnaire assessing beliefs of four types (about goals., norms, self and general beliefs) and an informational questionnaire were administered to five samples of 619 women differing in age, occupation, residential location and screening conditions. Discriminant analyses showed that the CO questionnaire provided significant predictions of physician-performed screening. regularity of screening, whether it was self-initiated or not, and breast self-examination. Predictions were not improved by including genetic risk for cancer. Women who attend for screening have beliefs supporting, for example. optimism, realism, emotional control, projecting good impression, and readiness to face problems. The implications of the study focus on the motivational dynamics of undergoing screening and the related personality profile, and on the possibility of modifying the relevant beliefs in order to increase uptake of screening.
Cognitive Function in Middle-aged Snorers and Controls: Role of Excessive Daytime Somnolence and Sleep-Related Hypoxic Events (1988)

Association of snoring and cognitive function was studied in 46 habitually snoring men ages 41-52 years, and 60 occasionally or never-snoring control male subjects of the same age group. Sleep recordings with monitoring of apneas and hypopneas were made with the static-charge sensitive bed method. Blood oxygen saturation was measured with an oximeter and the snoring sounds were recorded with a microphone after clinical and neuropsychological assessment. A questionnaire with items on excessive daytime somnolence (EDS), sleep, and snoring quality was also used. EDS (as measured by items on the questionnaire) associated with tests requiring concentration, memory retention, and verbal and spatial skills in the habitual snorers group. The number of oxygen desaturation episodes exceeding 4% associated with defective delayed Recall of Logical Stories of the Wechsler Memory Scale and with spatial orientation (Clock test) in the habitual snorers' group even after adjusting for age and obesity.
Studies of neutron production in (p,n) and (d,n) reactions for BNCT (2002)

The use of boron neutron capture therapy (BNCT) for the treatment of deep-seated tumours requires neutron beams of suitable energy and intensity. Simulations indicate the optimal energy is in the epithermal region, in particular between 1 and 10 keV. Therapeutic neutron beams with high spectral purity in this energy range could be produced with accelerator-based neutron sources through a suitable neutron-producing reaction. Herein, we report on different solutions that have been investigated as possible sources of epithermal neutron beams for BNCT.