gebhart/patrepeval huggingface dataset:
Neolignans, a Coumarinolignan, Lignan Derivatives, and a Chromene: Anti-inflammatory Constituents from <i>Zanthoxylum avicennae</i> (2008)

Eight new compounds, including four new neolignans, (7' S,8' S)-bilagrewin ( 1), (7' S,8' S)-5-demethoxybilagrewin ( 2), (7' S,8' S)-5- O-demethyl-4'- O-methylbilagrewin ( 3), and (7' S,8' S)-nocomtal ( 4), a new coumarinolignan, (7' S,8' S)-4'- O-methylcleomiscosin D ( 5), two new lignan derivatives, (+)-9'- O-( Z)-feruloyl-5,5'-dimethoxylariciresinol ( 6) and (+)-9'- O-( E)-feruloyl-5,5'-dimethoxylariciresinol ( 7), and a new chromene, ( E)-3-(2,2-dimethyl-2 H-chromen-6-yl)prop-2-enal ( 8), have been isolated from the stem wood of Zanthoxylum avicennae, together with 18 known compounds ( 9- 26). The structures of these new compounds were determined through spectroscopic and MS analyses. (7' S,8' S)-4'- O-Methylcleomiscosin D ( 5), cleomiscosin D ( 9), skimmianine ( 18), robustine ( 19), and integrifoliolin ( 23) exhibited inhibition (IC 50 < or = 18.19 microM) of superoxide anion generation by human neutrophils in response to formyl- l-methionyl- l-leucyl- l-phenylalanine/cytochalasin B (FMLP/CB). In addition, skimmianine ( 18) inhibited FMLP/CB-induced elastase release with an IC 50 value of 19.15 +/- 0.66 microM.
IGBT Stacks Based Pulse Power Generator for PIII&D (2005)

Plasma source ion implantation and deposition (PSII&D) is an emerging technology for surface treatment of metal and polymer materials. Through this technology it is possible to improve surface properties of the materials such as metals, plastics and ceramics. In this study, IGBT stacks based pulse power generator for PSII&D is proposed. The pulse generator uses six IGBT stacks and a step-up pulse transformer to generate high voltage pulse. Twelve IGBTs are connected in series in each IGBT to increase voltage rating of the pulse generator. Each IGBT stack uses a very simple driving method that has only two active drivers and eleven passive drivers (are composed of passive components such as resistors, capacitors, and diodes). Fault detection and fast protection are critical parts of the pulse power generator. The arc generation in the plasma load is common. Due to the arc in the plasma load, short current (overcurrent) condition is often generated. So the overcurrent detection and fast protection is implemented to protect pulse power generator in this paper.
Deep-Learning Full-Waveform Inversion Using Seismic Migration Images (2021)

Data-driven deep-learning full-waveform inversion (DD-DLFWI) can efficiently reconstruct a velocity image of the subsurface from prestack seismic recordings, once the deep-learning (DL) model is well-trained based on the self-designed geological structures and simulated recordings. However, the key problem of this approach is that it usually discards the knowledge about the forward and adjoint operators, which leads to poor reconstruction quality and generalization ability. To mitigate these problems, we have developed a deep-learning full-waveform inversion (DLFWI) approach using seismic migration images. This approach includes two key points. The first key point is that, unlike the conventional DD-DLFWI approach based on the seismic recordings in the common-source data domain, our approach utilizes the reverse time migration (RTM) images of seismic recordings in the common-source image domain as the data engine of the convolutional neural network (CNN) to reconstruct the background velocity. The second key point is that we utilize the iterative neural network architecture to reconstruct the high-resolution velocity model based on the reconstructed background velocity. Specifically, the high-resolution velocity model can be recovered by using the reconstructed velocity model, RTM image, and gradient of regularization term as the input of neural network architecture. Through synthetic experiments with various layered and fault velocity models, we have confirmed that the proposed approach can reconstruct a high-resolution velocity of the subsurface from prestack seismic recordings. Meanwhile, it outperforms the conventional DD-DLFWI approach in terms of reconstruction accuracy, antinoise, and generalization ability.
[Apoptosis of human myeloid leukemia cell line HL-60 cells induced by siRNA targeting gene c-myc]. (2009)

This study was purposed to investigate the effects of siRNA targeting c-myc on apoptosis induction, proliferation in inhibition as well as c-myc protein and mRNA expression in human myeloid leukemia cell line HL-60 cells. C-myc siRNA synthesized in vitro was transfected into HL-60 cells by liposome. Changes of cell morphology were observed. Growth inhibition was detected by MTT assay and colony formation assay, and cell apoptosis was determined by DNA ladder. The expressions of c-myc mRNA and protein were detected by RT-PCR and Western-blot respectively. The results indicated that c-myc siRNA remarkably inhibited the cell proliferation, with an IC(50) value of 150 nmol/L. Data of DNA ladder showed that HL-60 cells apoptosis could be efficiently induced by c-myc siRNA, the apoptosis rate positively correlated with the time duration of treatment with drugs. The c-myc mRNA and protein expressions on HL-60 cells decreased after treatment with c-myc siRNA, which negatively correlated with time duration of treatment. It is concluded that c-myc siRNA can efficiently induce growth inhibition, decrease the expressions of c-myc mRNA and protein, and induce apoptosis in HL-60 cells.
Constrained circuit optimization via library table genetic algorithms (2003)

Genetic Algorithms (GAs) are presented as a robust method of obtaining optimal or near-optimal solutions to circuit optimization problems. Circuits which must contain devices from a constrained "parts library" are shown to be particularly well-suited for optimization by genetic algorithms. As a practical example of the optimization method, a genetic algorithm implementation was used to optimize a Gilbert Cell mixer with respect to several competing metrics. The simulated power consumption, mixer gain, and IP3 of the mixer were used to construct a cost function. This cost function measure was minimized by the GA, producing several alternative Gilbert Cell mixers as outputs. The solution set was constrained to contain devices chosen from a library of previously characterized MOSFETs.
Recent Developments in PVC Polymerization (1988)

Abstract The scientific and patent literature on polymerization of vinyl chloride (VCM) is very extensive. A comprehensive review covering the literature up to about 1984 was recently done by Felger (1986). Some less comprehensive but very useful monographs have also been published fairly recently (see Burgess, 1982, and Butters, 1982). The present account primarily deals with fundamental work on VCM polymerization. No attempts have been made to include in this report contributions which are solely reported in the patent literature. The report concentrates on those aspects of VCM polymerization where recent work has provided us with a better understanding or new insight. The progress in the field made during the last few years is mainly due to the fad that new or strongly improved experimental techniques (e.g., more powerful spectroscopic methods) have become available.
Therapeutic value of the genus Alpinia, Zingiberaceae (2011)

Plants containing bioactive substances have increasingly become the object of research studies, particularly those plants with therapeutic value. Many species of the genus Alpinia provide a variety of medicinal properties, such as, Alpinia zerumbet (Pers.) Burtt et Smith and A. purpurata (Vieill) K. Schum, which have a significant presence in Brazil. These species have been commercialized in the food and cosmetic industries. However, their greatest importance arises from the medicinal properties of their essential oils containing flavonoids, terpenoids and kavalactones which have been used in folk medicine to treat, for example, arterial hypertension and inflammatory processes. In addition, such species are also used in multidisciplinary studies, including phytochemistry, ethnobotany and biology, indicating the key pharmacological role of this genus in everyday life. Therefore, this work aims to present a bibliographic review of the genus Alpinia and its significance in therapeutic applications.
Analysis of Insertion Force in Elastic/Plastic Mating (1990)

A simulation of an insertion of a solid pin into a slot between two opposing compliant beams is attempted. As a particular feature, the elastic-plastic deformation of the slot during the insertion is incorporated, as such a situation often occurs in electronic system interconnection. Each instance of the insertion process is considered as a static equilibrium of the insertion force and the contact force (including the frictional force). The equilibrium position of the deflected beams and the pin can be obtained as the point satisfying the following two conditions: 1) at the contact point, the contact force direction is offset from the normal direction to the contact points by the friction angle and, 2) the present positions of the contact points (one on the beam and the other on the pin), and their tangent angles must coincide exactly with each other. The simulated insertion force and depth relation agrees well with the real measurement.
HLA incompatible renal transplantation (2012)

With new agents being introduced into the armamentarium, which have not undergone rigorous investigation, it is important to emphasize that plasmapheresis, intravenous immunoglobulin, increased sharing, and kidney-paired donation are very effective strategies for transplanting sensitized patients. However, a significant population of patients will not benefit from either kidney-paired donation or desensitization and will require a hybrid technique in which the goal of matching is to reduce the strength of the DSA to facilitate desensitization.
Deep brain stimulation for obsessive-compulsive disorders: long-term analysis of quality of life (2013)

http://isrctn.org identifier: ISRCTN23255677.
Mineralocorticoid Synthesis During the Periovulatory Interval in Macaques1 (2006)

Ovulation and luteal formation in primates are associated with the sustained synthesis of progesterone. The observed high intrafollicular concentrations of progesterone during the periovulatory interval raise the possibility that this steroid serves as a precursor for mineralocorticoids. The aim of this study was to determine if mineralocorticoids are synthesized by the luteinizing macaque follicle during controlled ovarian stimulation cycles in which follicular fluid and granulosa cell aspirates were obtained before or after an ovulatory hCG bolus. Follicular fluid concentrations of progesterone and 17alpha-hydroxyprogesterone increased within 3 h of an ovulatory hCG bolus. Their respective metabolites, 11-deoxycorticosterone (DOC) and 11-deoxycortisol, were not detectable before an ovulatory stimulus and increased starting at 6 h after hCG, while corticosterone and aldosterone were undetectable. Cortisol was present before and after hCG administration and had increased 2-fold at 24 h after an ovulatory stimulus. The expression of 21-hydroxylase (CYP21A2) mRNA increased within 3 h of hCG administration, while 11beta-hydroxylase-1 (CYP11B1) and 11beta-hydroxylase-2 (CYP11B2) mRNAs were not detectable. 11beta-Hydroxysteroid dehydrogenase-1 (HSD11B1) mRNA had increased at 12 h after hCG administration, and 11beta-hydroxysteroid dehydrogenase-2 (HSD11B2) had decreased by 3 h after hCG administration. Mineralocorticoid receptor mRNA levels did not change following hCG administration, while glucocorticoid receptor mRNA levels increased in response to an ovulatory stimulus. Treatment of granulosa cells with the mineralocorticoid receptor antagonist spironolactone blocked hCG-induced progesterone synthesis in vitro. These data indicate that macaque granulosa cells can synthesize mineralocorticoids in response to an ovulatory stimulus and that the mineralocorticoid receptor plays a key role in steroid synthesis associated with luteinization of macaque granulosa cells.
On the performance of super-orthogonal turbo-transmit diversity for CDMA cellular communication (2002)

To achieve maximum theoretical system capacity in a Rayleigh fading environment, it has been shown that a combination of multiple transmit-receive antennas (given ideal channel state information and independent fading between antenna pairs) transmit and receive diversity will lead to the maximum achievable system capacity. In a CDMA environment, where the advantages of low rate coding for spreading purposes can be exploited, a coding-diversity gain, also known as space-time gain, can be achieved. This paper presents the new concept of layered super-orthogonal turbo transmit diversity (SOTTD) for code division multiple access (CDMA) communications. The techniques of spreading and coding at low-rate are married with code-division transmit diversity (CDTD) and iterative "turbo" processing. In layered space-time TC CDTD, a turbo encoder (and its associated iterative decoder) is required for every transmit diversity branch available. In SOTTD a single turbo encoder-decoder pair is required, making it a practically feasible solution. The only requirement being that the number of constituent encoders Z, should be greater or equal to the transmit diversity order M/sub T/. The principle of operation is to transmit the coded bits, stemming from the constituent encoders, via the spatial domain rather than via the time, code or frequency domain. The received data stream is then iteratively decoded using turbo decoding principles. SOTTD performance is compared with TC CDTD using both simulations and theoretical bounds.
Dual‐feed CSRR‐loaded switchable multiband microstrip patch antenna for ITS applications (2018)

A novel complementary split ring resonator (CSRR)‐loaded switchable multiband antenna with circular and linear polarisation switching is proposed for intelligent transportation system (ITS) application. It has one C‐shaped square patch with coaxial feeding and another direct coupled square‐ring patch with short‐ended microstrip feeding. In order to achieve switchable frequency response, a PIN‐diode is used. The proposed antenna is designed, fabricated, and experimentally tested. The measured data at the centre frequency 1.93, 3.73, 4.35, 5.9, 6.35, 7.25, and 8.75 GHz have impedance bandwidths of 50 MHz (1.90–1.95 GHz), 50 MHz (3.70–3.75 GHz), 500 MHz (4.10–4.60 GHz), 200 MHz (6.25–6.45 GHz), 300 MHz (7.10–7.40 GHz), and 600 MHz (8.45–9.05 GHz). The maximum bandwidth of the proposed antenna is 13%. The simulated and measured values of return loss of the antenna are in very good uniformity.
The mitochondrial-targeted peptide SBT-20 ameliorates inflammation and oxidative stress in chronic renal failure (2020)

Chronic renal failure (CRF) is the final outcome of the development of chronic kidney disease with different causes. Although CRF is a common clinical disease, its pathogenesis remains to be improved. SBT-20 belongs to a class of cell-permeable peptides that target the inner mitochondrial membrane, reduce reactive oxygen species (ROS), normalize electron transport chain function, and ATP generation. Our experiment was to evaluate whether SBT-20 affected the oxidative stress and inflammatory process of CRF. The levels of ROS production, mitochondrial membrane potential, NF- κB-p65, TNF-α, Drp1, and mfn2 were measured before and after SBT-20 treatment. We observed that SBT-20 treatment inhibited H2O2-induced mitochondrial ROS production. SBT-20 could also restore the mitochondrial membrane potential and reduce the elevated levels of NF-κB-p65 and TNF-α in HK-2 cells. <i>In vivo</i>, the renal function of CRF mice recovered after treating with SBT-20, the levels of necrotic cells and inflammation decreased, and the morphology of mitochondria recovered. The results showed that SBT-20 had a protective effect on CRF by reducing oxidative stress, inflammation progression <i>via</i> down-regulating of NF-κB-p65, TNF-α, and Drp1 and upregulating of Mfn2. These data support SBT-20 could be used as a potential preparation for CRF.
Allvac 718Plus, Superalloy for the Next Forty Years (2005)

Allvac 718Plus alloy is a new nickel base superalloy, offering excellent mechanical properties, increased temperature capability, good fabricability and moderate cost. This highly desirable combination of characteristics positions the alloy to very effectively fill the longstanding gap between the two most widely used wrought superalloys, 718 and Waspaloy. This paper will review the development of alloy 718Plus, which has progressed over the last eight years, including the effects of chemistry, heat treatment, processing and structure on mechanical properties. The current production status and capability of the alloy will also be discussed along with ongoing applications development. Comparisons will be made to 718, Waspaloy and other superalloys illustrating that alloy 718Plus is the best available candidate to sustain the advances in engine development made possible by the forty-plus year life of alloy 718.
Gastrointestinal Polyposis Syndromes (2007)

Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS).
《伟大的象征:顾拜旦和近代奥林匹克运动起源》评介 (1984)

正如J.J.麦卡隆所说的那样,讲述奥林匹克运动会的故事,“需要心甘情愿地去跨越各种不同学科的边界,这些学科中包括历史学、人类学、社会学、心理学、文学评论和古代希腊罗马研究”。幸亏本书作者在各方面的条件都已具备,足以跨越这些边界;更为重要的是,他当初就是一位出色的运动员,在读大学的时候就是一位赛跑选手,“成绩很好,大有希望当上美国代表队队员”。当他访问希腊奥林匹亚运动场的时候,他情不自禁地要创造出自己的好成绩,跑下那段赛程。为了获悉有关奥林匹克运动会的更多情况,他查阅了许多所图书馆的藏书,然而所获甚微,于是他就决定亲自来把这项研究工作进行到底。本书就是作者花费10年时间专心研究的结晶。
Mixing Tests: Diagnostic Aides in the Investigation of Prolonged Prothrombin Times and Activated Partial Thromboplastin Times (2013)

Mixing tests are a relatively simple procedure used in the hemostasis laboratory as a first-line investigation into the cause of an abnormal screening test, typically a prolonged activated partial thromboplastin time and/or a prolonged prothrombin time. The mixing test involves combining the test plasma with normal plasma, then repeating the screening test on the mixture to assess whether the clotting time becomes normal or remains prolonged. The primary purpose of a mixing test is to guide further investigations. When mixing test results "normalize," this suggests the test plasma is deficient in clotting factor(s) and thus specific factor assays can be performed to determine which are reduced. When the mixing test result does not "normalize," this suggests the presence of an inhibitor or other type of interference (e.g., the presence of an anticoagulant such as high-dose heparinoids), and so the laboratory needs to determine if this is a lupus anticoagulant or a specific coagulation factor inhibitor, or another type of inhibitor. Because these follow-up investigations are more costly and time-consuming than the basic screening tests, the appropriate performance and interpretation of mixing tests is advantageous for the laboratory. Moreover, the correct laboratory approach is also clinically relevant, as patient management is ultimately affected, and an incorrect interpretation may lead to inappropriate therapies being established. Components of a mixing test that can influence result interpretation include the sensitivity of the used screening reagents to various factor deficiencies and inhibitors, the source or composition of the normal plasma, and the setting of cutoffs for the formula used in expressing mixing test results. Numerous and differing criteria for mixing test interpretation have been suggested historically, which can lead to confusion as to which approach is the most appropriate. The use of differing criteria will also lead to differing interpretations regarding "normalization." For this pivotal reason, standardized mixing test procedures and a consistent set of validated interpretive criteria represent the most favorable approach to maximizing the utility of a mixing test, and ensure the most accurate diagnosis for investigated patients.
Sequential Hypothesis Testing based Polling Interval Adaptation in Wireless Sensor Networks for IoT Applications (2017)

It is well known that duty-cycling control by dynamically adjusting the polling interval according to the traffic loads can effectively achieve power saving in wireless sensor networks. Thus, there has been a significant research effort in developing polling interval adaptation schemes. Especially, Dynamic Low Power Listening (DLPL) scheme is one of the most widely adopted open-looping polling interval adaptation techniques in wireless sensor networks. In DLPL scheme, if consecutive idle (busy) samplings reach a given fixed threshold, the polling interval is increased (decreased). However, due to the trial-and-error based approach, it may significantly deteriorate the system performance depending on given threshold parameters. In this paper, we propose a novel DLPL scheme, called SDL (Sequential hypothesis testing based Dynamic LPL), which employs sequential hypothesis testing to decide whether to change the polling interval conforming to various traffic conditions. Simulation results show that SDL achieves substantial power saving over state-of-the-art DLPL schemes.
DNA topoisomerase IIα and -β expression in human ovarian cancer (1999)

To study DNA topoisomerase IIalpha (Topo-IIalpha) and -beta expression and regulation in human ovarian cancer, 15 ovarian tumour samples were investigated. To compare different levels of expression, the samples were screened for topo IIalpha and -beta mRNA with Northern blotting and a quantitative reverse transcriptase polymerase chain reaction (RT-PCR) assay for Topo-IIalpha mRNA. Additionally, protein levels were determined with Western blotting and topoisomerase II activity levels with the decatenation assay. The results obtained were compared with each other and with the tumour volume index of the samples. In tumours with a tumour volume index > or = 50%, the mRNA levels (as determined by Northern blotting) and protein levels for each isozyme were in accordance. Additionally, correlations were found between Topo-IIalpha RT-PCR data and Topo-IIalpha Northern blot results, and between Topo-IIalpha RT-PCR data and Topo-IIalpha protein levels. Interestingly, Topo-IIbeta protein levels correlated better with Topo-II activity than Topo-IIalpha protein levels. In eight ovarian cystadenoma samples, no Topo-IIalpha protein could be found. In only three out of eight of these cystadenomas, Topo-IIbeta protein could be detected. These findings suggest that Topo-IIalpha and Topo-IIbeta protein levels are up-regulated in ovarian cancer and may indicate that Topo-IIbeta is an interesting target for chemotherapy in ovarian tumours.