gebhart/patrepeval huggingface dataset:
First experiences with single-dose treatment of vaginal trichomoniasis with carnidazole (R 25831). (1977)

This paper reports the results of treating 152 women with carnidazole, a new trichomonacidal drug. They were divided into two groups. The first comprised 91 patients who were treated with 2 g, while the second group comprised 61 patients who were treated with 1-5 g carnidazole in a single oral dose. Defaulter rates were 6-6% for the first group and 13-1% for the second. Of the remaining 85 patients in the first group, 76 (89-5%) were negative at the first follow-up one to three weeks after treatment, three (3-5%) were considered to be treatment failures, and six (7-0%) were considered to be reinfected. Of 53 women treated with 1-5 g, 39 (73-6%) were negative at first follow-up, eight (15-1%) were considered to be treatment failures, and six (11-3%) were considered to be reinfected. The difference between the number of patients cured in both groups is statistically significant. Fourteen patients experienced side-effects, but these were of little significance. Carnidazole given in a single oral dose of 2 g in 16 women did not cause consistent changes in any of the haematological and biochemical parameters studied.
Palladium-Alloy Catalysts as Ethanol and Methanol Tolerant Cathodes for Direct Alcohol Fuel Cell Applications (2006)

Abstract not Available.
Effects of radiation pattern and attenuation on<i>P</i>and<i>S</i>amplitudes in a three‐component VSP: a case history (1983)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1983Effects of radiation pattern and attenuation on P and S amplitudes in a three‐component VSP: a case historyAuthors: T. H. KehoM. N. ToksözC. H. ChengM. D. PrangeR. M. TurpeningT. H. KehoM. I. T., M. N. ToksözM. I. T., C. H. ChengM. I. T., M. D. PrangeM. I. T., and R. M. TurpeningM. I. T.https://doi.org/10.1190/1.1893709 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1893709FiguresReferencesRelatedDetailsCited byParsimonious migration of 3-C 3D VSP dataYogesh Agnihotri and George A. McMechan13 September 2007 | GEOPHYSICS, Vol. 72, No. 6 SEG Technical Program Expanded Abstracts 1983ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1983 Pages: 646 publication data© 1983 Copyright © 1983 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 24 Mar 2005 CITATION INFORMATION T. H. Keho, M. N. Toksöz, C. H. Cheng, M. D. Prange, and R. M. Turpening, (1983), "Effects of radiation pattern and attenuation on P and S amplitudes in a three‐component VSP: a case history," SEG Technical Program Expanded Abstracts : 592-594. https://doi.org/10.1190/1.1893709 Plain-Language Summary PDF DownloadLoading ...
A 2.6 MHz PHASED ARRAY ULTRASONIC PROBE USING 0.67Pb(Mg1/3Nb2/3)O3-0.33PbTiO3 SINGLE CRYSTAL GROWN BY THE BRIDGMAN METHOD. (2002)

The performance of 64channel 2.6 MHz phased array ultrasonic probe using 0.67Pb(Mg1/3 Nb2/3)O3-0.33PbTiO3 single crystal was investigated. The fabrication process was modified as the mechanical and electrical properties difference between PMN-PT single crystal and conventional PZT. The sensitivity of the PMN-PT single crystal probe is about 6 dB higher than that of the conventional PZT probe, and the -6 dB bandwidth is about 30 % broader. The sensitivity variation of PMN-PT probe was within ±2.0dB. The performance of PMN-PT probe with higher sensitivity was better than that of PZT probe in harmonic image. And the color Doppler of PMN-PT probe is superior than that of PZT probe. The PMN-PT single crystal provides improvement in the sensitivity and bandwidth.
Engineering, Expression in Transgenic Plants and Characterisation of E559, a Rabies Virus-Neutralising Monoclonal Antibody (2014)

Rabies post-exposure prophylaxis (PEP) currently comprises administration of rabies vaccine together with rabies immunoglobulin (RIG) of either equine or human origin. In the developing world, RIG preparations are expensive, often in short supply, and of variable efficacy. Therefore, we are seeking to develop a monoclonal antibody cocktail to replace RIG. Here, we describe the cloning, engineering and production in plants of a candidate monoclonal antibody (E559) for inclusion in such a cocktail. The murine constant domains of E559 were replaced with human IgG1κ constant domains and the resulting chimeric mouse-human genes were cloned into plant expression vectors for stable nuclear transformation of Nicotiana tabacum. The plant-expressed, chimeric antibody was purified and biochemically characterized, was demonstrated to neutralize rabies virus in a fluorescent antibody virus neutralization assay, and conferred protection in a hamster challenge model.
Umsetzungen von 2-chlor- und 2-organoaminosubstituierten 5.6-Benzo-1,3-dimethyl-1,3,2-diazaphosphorinan-4-onen mit Aziden / Reactions of 2-Chloro- and 2-Organoamino-Substituted 5.6-Benzo-1,3-dimethyl-1,3,2-diazaphosphorinane-4-ones with Azides (1994)

The reaction of 5,6-benzo-2-chloro-1,3-dimethyl-1,3,2-diazaphosphorinane-4-one (1) with trimethylsilyl azide led to the substituted cyclotriphosphazene (3). A monomeric reaction product was not observed by NMR spectroscopy. The diazaphosphorinane 2, with the 2-chloroethyl substituent bonded to the nitrogen atom in a-position to the carbonyl group, did not react with trimethylsilyl azide. An attempt to prepare 3 from N,N'-dimethylanthranilamide 5 and hexachlorocyclotriphosphazene 4 failed, as did the attempt to react 5 with phosphorus pentachloride. The reaction of 5,6-benzo-2-{bis(2-chloroethyl)amino}-1,3-dimethyl- 1.3.2-diazaphosphorinane-4-one (7) and of the related compound 9, bearing only one 2-chloroethyl substituent, with 4-nitrobenzoyl azide furnished, in a normal Staudinger fashion, the monomeric products 8 and 10. In the case of 10, intramolecular P=O···H interaction was demonstrated by IR spectroscopy.
Self‐splicing and Enzymatic Activity of an Intervening Sequence RNA from <i>Tetrahymena</i> (Nobel Lecture) (1990)

Biological catalysis by RNA–this discovery at the beginning of the 1980s was sensational, since it had been assumed that only proteins were capable of functioning as biocatalysts. Sidney Altman studied the enzyme ribonuclease P, which is composed of RNA and protein subunits, and found conditions under which the RNA component could catalyze the formation of mature tRNA in the absence of protein. Thomas R. Cech discovered the phenomenon of self-splicing rRNA in Tetrahymena thermophila. This rRNA catalyzes the consecutive transesterification of specific phosphodiester groups in its nucleotide sequence and thereby the excision of an intervening sequence (IVS; see picture below) and ligation of the remaining rRNA molecule. The work of Altman and Cech, for which they were awarded the Nobel Prize in chemistry in 1989, upset a paradigm in biochemistry.
A proposed resistance-to-time converter with switching impulse calibrators for resistive bridge sensors (2017)

This paper presents a simple resistance-to-time converter. It consists of two voltage comparators, a ramp voltage generator, two logic gates and impulse voltage calibrators. A square-wave generator circuit is suggested in this paper. The design is simple and independent of the OPAMP offset issues. The resulting square-wave is rectified to get its DC equivalent and to a triangular output; the two outputs are applied to a comparator for generating a digital output with duty cycle proportional to a change in resistance upon which is dependent the DC.
Charging and discharging studies in microwave capacitive switches under high field pulse discharges (2010)

This paper investigates the impact of pulse induced charging on RF-MEMS capacitive switches. The main goal here is to better understand the charging and discharging process involved in high field discharges. This is a necessary study for the reason that the reliability of the structure is directly affected by the underlying charging/discharging processes. Electrostatic discharge (ESD) experiments were carried out using a transmission-line-pulsing technique and compared with a human-body-model testing method. The tests were done on a test-vehicle design of a W-band capacitive RF-MEMS switch. Base on capacitance vs. voltage measurements we highlight the importance of the dielectric material properties and its impact on the device immunity with respect to pulse induced failure mechanisms.
The Use of Expression Profiling to Study Pigment Cell Biology and Dysfunction (2000)

Regulation of gene expression is a fundamental process by which cells respond to both intracellular and extracellular signals. For a pigment cell, alterations in gene expression regulate the processes of cell migration, lineage restriction, differentiation, type of pigment produced, and progression from a normal pigment cell to that of melanoma. To date, the identification of genes involved in normal pigment cell development has been accomplished by the cloning of individual mutant alleles, a single gene at a time. Current advances in technology have now made it possible to use expression profile analysis to investigate, on a genomic scale, the process of pigment cell development and function. This review compares and contrasts the methods of subtractive suppressive polymerase chain reaction (PCR) and differential display with that of cDNA microarray analysis.
Activin and Its Receptors during Gastrulation and the Later Phases of Mesoderm Development in the Chick Embryo (1995)

We have cloned chick homologues of the type-II activin receptor, which we have designated cActR-IIA and -IIB. Binding assays show that the two receptors are indistinguishable in their ability to bind activin-A, with comparable kds. Injection of mRNAs encoding these receptors into Xenopus embryos causes axial duplications. Expression of both receptors can first be detected in the primitive streak by in situ hybridization. This suggests that these genes may be activated in response to mesoderm induction. In agreement with this, we find that treatment of preprimitive streak chick embryos with activin-A leads to rapid induction of the expression of cActR-IIB. At later stages, cActR-IIA transcripts become localized mainly in the notochord and myotome and cActR-IIB in the dorsal neural tube, proximal-anterior part of the limb bud, sensory placodes, and specific regions of the fore- and midbrain. To test the response of early chick embryonic tissues to activin, we designed a new in vitro assay for differentiation. We find that explants of area opaca epiblast or posterior primitive streak from various stages can respond to activin treatment by differentiating into a variety of mesodermal cell types in a dose-dependent manner. These results suggest that the importance of activin-related signaling pathways is not confined to pregastrulation stages and that these receptors may be involved in mediating the effects of inducing signals during later stages of development of the mesoderm, limbs, and nervous system.
Approximation of exponential-type functions on a uniform grid by shifts of a basis function (2015)

In this paper, we study the problem of interpolating a continuous function at $(n+1)$ equally-spaced points in the interval $[0,1]$, using shifts of a kernel on the $(1/n)$-spaced infinite grid. The archetypal example here is approximation using shifts of a Gaussian kernel. We present new results concerning interpolation of functions of exponential type, in particular, polynomials on the integer grid as a step en route to solve the general interpolation problem. For the Gaussian kernel we introduce a new class of polynomials, closely related to the probabilistic Hermite polynomials and show that evaluations of the polynomials at the integer points provide the coefficients of the interpolants. Taking cue from the classical Newton polynomial interpolation, we derive a closed formula for the Gaussian interpolant of a continuous function on a uniform grid in the unit interval.
[Regulatory T lymphocytes expressing L-selectin in children and adolescents with type 1 diabetes mellitus]. (2010)

The lower percentage of Tregs and CD62Lhigh Tregs may contribute to ineffective suppression of proinflammatory cytokine production during type 1 diabetes. We suggest the protective role of anti-TNF on Treg subset in diabetic type 1 patients and we highlight the importance of proinflammatory cytokine - TNF-alpha, which may be responsible for quantitative abnormalities in Treg subset in these patients.
Time-Averaged and Time-Accurate Aero-Dynamics for the Recessed Tip Cavity of a High-Pressure Turbine Blade and the Outer Stationary Shroud: Comparison of Computational and Experimental Results (2004)

The unsteady aero-dynamics of a single-stage high-pressure turbine blade operating at design corrected conditions has been the subject of a thorough study involving detailed measurements and computations. The experimental configuration consisted of a single-stage high-pressure turbine and the adjacent, downstream, low-pressure turbine nozzle row. All three blade-rows were instrumented at three spanwise locations with flush-mounted, high frequency response pressure transducers. The rotor was also instrumented with the same transducers on the blade tip and platform and the stationary shroud was instrumented with pressure transducers at specific locations above the rotating blade. Predictions of the time-dependent flow field around the rotor were obtained using MSU-TURBO, a 3D, non-linear, computational fluid dynamics (CFD) code. Using an isolated blade-row unsteady analysis method, the unsteady surface pressure for the high-pressure turbine rotor due to the upstream high-pressure turbine nozzle was calculated. The predicted unsteady pressure on the rotor surface was compared to the measurements at selected spanwise locations on the blade, in the recessed cavity, and on the shroud. The rig and computational models included a flat and recessed blade tip geometry and were used for the comparisons presented in the paper. Comparisons of the measured and predicted static pressure loading on the blade surface show excellent correlation from both a time-average and time-accurate standpoint. This paper concentrates on the tip and shroud comparisons between the experiments and the predictions and these results also show good correlation with the time-resolved data. These data comparisons provide confidence in the CFD modeling and its ability to capture unsteady flow physics on the blade surface, in the flat and recessed tip regions of the blade, and on the stationary shroud.
Mode of tumor penetration of intravenously administered liposomal doxorubicin (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

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The use of liposomes as vehicles to transport anticancer drugs to increase drug effectiveness and decrease toxicity has been studied for several decades. A large number of reports on the uptake of liposome particles by tumor cells in vitro and dispersion in solid tumor have been published. However, since liposome particles are not stable under the conditions of the regular procedures of tissue staining, the standard methodologies have not clearly demonstrated the exact process by which liposome particles penetrate solid tumor tissue. In this study, we used rhodamine-labeled latex microspheres that mimic the particle size (100 nm) and electric charge of liposome particles as well as DSPC pegylated liposomal doxorubicin to visualize pentration of nanoparticles into solid tissue tumors. Solid tumors of L1210 cells transplanted subcutaneously in DBA2 mice and human oral carcinoma cells transplanted in SCID mice were used as animal models in this study. After i.v. injection through the tail vein, tumor tissue samples were collected at different time points, and immediately embedded in O.C.T. Cryosections (0.6 μm) of this sample were stained using anti-mouse CD31 to localize endothelial cells in blood vessels which were visualized by the green fluorescence of a FITC-streptavidin-biotin system. In these sections, the blue fluorescence of the dye DAPI was used to identify the nuclei of the tumor cells. Red fluorescent liposomal particles or rhodaminine-labeled latex microspheres were also readily detected in the sections under a fluorescent microscope. The results showed that the model nanoparticles could only enter the tumor tissue at certain foci presumably representing leaky sites in the blood vessels and spread locally. The findings could be used to explain the observed differences in anticancer effectiveness among tissue-targeted liposomal doxorubicin, non-targeted liposomal doxorubicin and free doxorubicin.
Crystal Structure of Zeolite X Exchanged with Pb(II) at pH 6.0 and Dehydrated:  (Pb<sup>4+</sup>)<sub>14</sub>(Pb<sup>2+</sup>)<sub>18</sub>(Pb<sub>4</sub>O<sub>4</sub>)<sub>8</sub>Si<sub>100</sub>Al<sub>92</sub>O<sub>384</sub> (1997)

A single crystal of zeolite X was 39% overexchanged with aqueous Pb2+ at pH 6.0. After dehydration at 420 °C and 2 × 10-6 Torr, its crystal structure was determined by X-ray diffraction techniques in the cubic space group Fd3̄ at 21 °C (a = 25.238(5) Å). The structure, Pb64O32−Si100Al92O384 per unit cell, was refined to the final error indices R1 = 0.080 and R2 = 0.070 with 486 reflections for which I > 3σ(I). Pb4+ formed upon evacuation at elevated temperature by a reaction which may be written, per unit cell, as 64 Pb2+ + 36 OH- → 18 Pb2+ + 8 Pb4O4 + 14 Pb4+ + 14 H2 + 4 H2O. Pb ions occupy three nonequivalent sites. Each of 14 lead ions at site II is nearly in a six-ring plane where it coordinates to three framework oxygens at 2.32(2) Å and to a nonframework oxygen at 2.24(2) Å; these short distances indicate that these are Pb4+. Eighteen Pb2+ ions, also at site II, are 2.54(2) Å from three framework oxygens and 2.95(2) Å from a nonframework oxygen. Each sodalite cage is filled by a nearly cubic Pb4O4 cluster with Pb2+ and O2- ions alternating; the four Pb2+ ions (32 per unit cell) are at site I‘; each is 2.67(2) Å from three framework oxygens and 2.59(3) Å from three nonframework oxygens. Each Pb4O4 cube bonds radially via its oxygens through six-rings to four additional lead ions (Pb2+ and Pb4+) to give larger cationic clusters, perhaps predominantly of formula [Pb8O4]12+. The 18 Pb2+ ions which are external to the Pb4O4 cubes appear to have axial nonbonding lone pairs which extend into the supercage.
Attention Deficit Hyperactivity Disorder (2005)

Abstract Attention deficit hyperactivity disorder is a childhood syndrome characterized by developmentally inappropriate inattention, impulsivity, and hyperactivity which produces impairment at home and school. Long‐term outcome is poor, but treatment with stimulant medication and behavior modification is effective. Investigations of the disorder and its treatments suggest a dopamine deficit exists that may be corrected by stimulant medication.
Optical Refrigeration to NIST Cryogenic Temperature at 123K (2012)

A record low temperature in optical refrigeration is demonstrated by cooling Yb:YLF crystal to 128K ± 5K (∼−150 C) at λ=1020 nm corresponding to its E4-E5 Stark manifold resonance. The estimated cooling power is 165 mW.
EMPLOYMENT PROTECTION: <i>Section 11, sick pay and the demise of the “officious bystander”</i> (1982)

Journal Article EMPLOYMENT PROTECTION: Section 11, sick pay and the demise of the “officious bystander” Get access PAT LEIGHTON, PAT LEIGHTON *Polytechnic of North London Search for other works by this author on: Oxford Academic Google Scholar BRIAN DOYLE BRIAN DOYLE †University of Salford Search for other works by this author on: Oxford Academic Google Scholar Industrial Law Journal, Volume 11, Issue 1, 1982, Pages 185–188, https://doi.org/10.1093/ilj/11.1.185 Published: 01 June 1982
Intracardiac ablatherapy using high frequency catheter: first ‘'in vivo'' experiments (1994)

International audience
Investigating cardiolocomotor synchronization during running in trained and untrained males (2015)

Introduction This study aims at investigating the coupling of the cardiac and locomotor systems during running in trained and untrained males. Methods Sixteen healthy young males subjects were submitted to an anthropometric evaluation, followed by a treadmill test at 70% to 75% of heart rate reserve. Based on the average velocity, they were divided into two groups of eight, trained group (TG) and untrained group (UT). The electrocardiogram and the electromyogram of the vastus lateralis muscle of the right thigh were digitized at a sampling rate of 1000 Hz, and processed off-line. Each cardiac and electromyographic cycle was detected to further investigate the coupling between cardiac and running rates in time domain, using the cross-correlation, and in the frequency domain, using a phase synchronization measure based on the Hilbert transform. A Shannon entropy index and magnitude squared coherence were also applied to improve analysis. Results Both groups presented low cross-correlation (0.18 ± 0.07 TG and 0.15 ± 0.08 UG) values between these signals, and only four from 16 subjects presented short epochs of phase synchronization (4.1 ± 8.6% TG and 3.2±7.3% UG) between signals, occurring at a low frequency band and random phase differences. The low to moderate coherence (0.67 ± 0.16 TG and 0.64 ± 0.16 UG) observed at 0.1 Hz appears to be an effect of the simultaneous action of sympathetic system over both cardiac and muscular rhythms. Conclusion The combined results suggest that the chosen exercise protocol was not able to cause cardiolocomotor synchronization.
Absorption, distribution, excretion and tissue uptake of 99mtechnetium labeled hyaluronan (HA) after single oral doses in rats and beagle dogs (2008)

High‐molecular weight HA (HyaMax®, 1 MDa) labeled with 99m Technetium ( 99m Tc‐HA) or free 99m Technetium pertechnetate ( 99m Tc) administered to rats/dogs per os. Distribution of radioactivity in blood & tissues of rats was determined at 5,15,30 mins, 1,2,4,6,12,24,48,72 hrs. Urinary & fecal excretion determined in rats at 12,24,48,72 hrs. Blood & urinary clearance determined in dogs. Scintigraphic imaging, autoradiography of tissue pieces & SPECT/CT scans evaluated tissue uptake in rats. 99m Tc‐HA was labeled with 85% efficiency & stable for >48 hrs. Blood levels of radioactivity for 99m Tc‐HA peaked 2–4 hrs in rats/dogs. Most tissues examined showed incorporation of radioactivity at 15 mins up to 48 hrs. After 72 hrs, 86.7% of radioactivity from 99m Tc‐HA recovered, almost all in feces; 94.4% from 99m Tc, almost all from urine. Autoradiography showed incorporation of radioactivity from 99m Tc‐HA, but not free 99m Tc, in skin, bones & joints at 24 hrs. Absorption/distribution of free 99m Tc was completely different from 99m Tc‐HA, showing a pattern of rapid absorption & excretion, with accumulation in thyroid glands, & removal via urine. Control experiments indicated radioactivity in tissues after 99m Tc‐HA not due to free 99m Tc‐HA. Shows evidence for uptake of 13.3% of oral dose of high‐molecular‐weight HA, with accumulation in connective tissues. Supported by Fenchem Biotek and Schiff Nutrition International.
Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells (2015)

In this work the selective uptake of native horse spleen ferritin and apoferritin loaded with MRI contrast agents has been assessed in human breast cancer cells (MCF-7 and MDA-MB-231). The higher expression of L-ferritin receptors (SCARA5) led to an enhanced uptake in MCF-7 as shown in T2 and T1 weighted MR images, respectively. The high efficiency of ferritin internalization in MCF-7 has been exploited for the simultaneous delivery of curcumin, a natural therapeutic molecule endowed with antineoplastic and anti-inflammatory action, and the MRI contrast agent Gd-HPDO3A. This theranostic system is able to treat selectively breast cancer cells over-expressing ferritin receptors. By entrapping in apoferritin both Gd-HPDO3A and curcumin, it was possible to deliver a therapeutic dose of 167 μg ml(-1) (as calculated by MRI) of this natural drug to MCF-7 cells, thus obtaining a significant reduction of cell proliferation.