gebhart/patrepeval huggingface dataset:
Singular Value Decomposition Analysis of Spectroelectrochemical Redox Chemistry in Supramolecular Dye Nanotubes (2011)

The redox chemistry of supramolecular nanotubes self-assembled from amphiphilic cyanine dye 3,3′-bis(2-sulfopropyl)-5,5′,6,6′-tetrachloro-1,1′-dioctylbenzimidacarbocyanine (C8S3) in aqueous solution was investigated by spectroelectrochemistry. The absorption spectra during the redox-reaction were analyzed by singular value decomposition (SVD) and semiempirical quantum mechanical calculations. Previously unavailable absorption spectra were modeled for each species of the reaction at every point throughout the oxidation and reduction process. The expected peak absorption wavelengths of these species present throughout the electrochemical cycles were calculated using the semiempirical method ZINDO/S (Zerner method of intermediate neglect of differential overlap for spectroscopy). The spectral assignments from the proposed species derived from the SVD analysis were confirmed with the ZINDO/S calculations, supporting the assignment of the key species as well as the intermediates in the proposed redox-reaction scheme. The oxidized species have spectral signatures that agree with the calculated spectral maxima of isolated species, indicating that the resulting products are not electronically perturbed by aggregation, in strong contrast to the unoxidized dye.
Methods for Monitoring, Controlling and Charging QoS in IP Networks (2001)

Internet Protocol (IP)-based networks and TCP/IP-applications are steadily getting more popular. Many applications require more than best-effort service, i.e. they need Quality of Service
Photoperiodic Modulation of Clock Gene Expression in the Avian Premammillary Nucleus (2009)

The premammillary nucleus (PMM) has been shown to contain a daily endogenous dual-oscillation in dopamine (DA)/melatonin (MEL) as well as c-fos mRNA expression that is associated with the daily photo-inducible phase of gonad growth in turkeys. In the present study, the expression of clock genes (Bmal1, Clock, Cry1, Cry2, Per2 and Per3) in the PMM was determined under short (8 : 16 h light/dark cycle) and long (16 : 8 h light/dark cycle) photoperiods relative to changes associated with the diurnal rhythm of DA and MEL. Constant darkness (0 : 24 h light/dark cycle) was used to assess the endogenous response of clock genes. In addition, light pulses were given at zeitgeber time (ZT) 8, 14 and 20 to ascertain whether clock gene expression is modulated by light pulse stimulation and therefore has a daily phase-related response. In the PMM, the temporal clock gene expression profiles were similar under short and long photoperiods, except that Per3 gene was phase-delayed by approximately 16 h under long photoperiod. In addition, Cry1 and Per3 genes were light-induced at ZT 14, the photosensitive phase for gonad recrudescence, whereas the Clock gene was repressed. Gene expression in established circadian pacemakers, the visual suprachiasmatic nucleus (vSCN) and the pineal, was also determined. Clock genes in the pineal gland were rhythmic under both photoperiods, and were not altered after light pulses at ZT 14, which suggests that pineal clock genes may not be associated with the photosensitive phase and reproductive activities. In the vSCN, clock gene expression was phase-shifted depending on the photoperiod, with apexes at night under short day length and during the day under long day length. Furthermore, light pulses at ZT 14 induced the Per2 gene, whereas it repressed the Bmal1 gene. Taken together, the changes in clock gene expression observed within the PMM were unique compared to the pineal and vSCN, and were induced by long photoperiod and light during the daily photosensitive phase; stimuli that are also documented to promote reproductive activity. These results show that Cry1 and Per3 are involved in the photic response associated with the PMM neuronal activation and are coincident with an essential circadian mechanism (photosensitive phase) controlling the reproductive neuroendocrine system.
The Modulation of Ca2+ Binding to Sarcoplasmic Reticulum ATPase by ATP Analogues Is pH-dependent (1995)

Excess ATP is known to enhance Ca(2+)-ATPase activity and, among other effects, to accelerate the Ca2+ binding reaction. In previous work, we studied the pH dependence of this reaction and proposed a 3H+/2Ca2+ exchange at the transport sites, in agreement with the H+/Ca2+ counter transport. Here we studied the effect of ADP and nonhydrolyzable ATP analogues on the Ca2+ binding reaction at various pH values. At pH 6, where Ca2+ binding is monophasic and slow, ADP, adenosine 5'-(beta,gamma-methylene)triphosphate (AMP-PCP), or adenyl-5'-yl imidodiphosphate (AMPPNP) increased the Ca2+ binding rate constant 20-fold. At pH 7 and 8, where Ca2+ binding is biphasic, the nucleotides induce fast and monophasic Ca2+ binding. At pH 7, AMP-PCP accelerated Ca2+ binding with an apparent dissociation constant of 10 microM. At acidic pH, ADP, AMPPCP, or AMPPNP increased the equilibrium affinity of Ca2+ for ATPase, whereas at alkaline pH, these nucleotides had no effect. At pH 5.5, AMPPCP increased equilibrium Ca2+ binding with an apparent dissociation constant of 1 microM.
Fabrication of a 99%-Energy-Less Nonvolatile Multi-Functional CAM Chip Using Hierarchical Power Gating for a Massively-Parallel Full-Text-Search Engine (2013)

A ternary content-addressable memory (TCAM)-based hardware called nonvolatile “multi-functional CAM (MF-CAM)” is proposed for an ultra-low-energy “full-text search” system in recent data centers. The proposed nonvolatile MF-CAM-based full-text search engine can perform parallel comparison while eliminating leakage energy by hierarchical power gating. By the massively parallel comparison with the hierarchical power gating, energy consumption of the proposed search engine is reduced within 1% in comparison with the conventional CPU-based full-text search system, where repetitive comparisons between the CPU and a memory consume much energy.
COUPLING DNA REPLICATION TO THE CELL CYCLE (1996)

Conference Abstract| November 01 1996 COUPLING DNA REPLICATION TO THE CELL CYCLE R.A. Laskey; R.A. Laskey Search for other works by this author on: This Site PubMed Google Scholar T. Krude; T. Krude Search for other works by this author on: This Site PubMed Google Scholar M. Madine; M. Madine Search for other works by this author on: This Site PubMed Google Scholar D. Coverley; D. Coverley Search for other works by this author on: This Site PubMed Google Scholar P. Romanowski; P. Romanowski Search for other works by this author on: This Site PubMed Google Scholar A.D. Mills A.D. Mills Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (4): 507S. https://doi.org/10.1042/bst024507sb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation R.A. Laskey, T. Krude, M. Madine, D. Coverley, P. Romanowski, A.D. Mills; COUPLING DNA REPLICATION TO THE CELL CYCLE. Biochem Soc Trans 1 November 1996; 24 (4): 507S. doi: https://doi.org/10.1042/bst024507sb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Illustration of complex real-world objects using images with normals (2007)

This paper investigates the creation of non-photorealistic illustrations from a type of data lying between simple 2D images and full 3D models: images with both a color (albedo) and a surface normal stored at each pixel. Images with normals combine an acquisition process only mildly more complex than that for digital photographs (and significantly easier than 3D scanning) with the power and flexibility of tools similar to those originally developed for full 3D models. We investigate methods for signal processing on images with normals, developing algorithms for scale-space analysis, derivative (i.e., curvature) estimation, and segmentation. These are used to implement analogues of stylized rendering techniques such as toon shading, line drawing, curvature shading, and exaggerated shading. We also introduce new stylization effects based on multiscale mean curvature shading, as well as fast discontinuity shadows. We show that our rendering pipeline can produce detailed yet understandable illustrations in medical, technical, and archaeological domains.
Spin Trapping of Free Radicals and Lipid Peroxidation in Microsomal Preparations from Malignant Hyperthermia Susceptible Pigs (1990)

Microsomes were prepared from livers of malignant hyperthermia susceptible (MHS) or resistant (MHR) pigs. On incubation with the spin trap alpha-(4-pyridyl-l-oxide)-N-tert-butylnitrone (4-POBN), the microsomes from MHS pigs produced a characteristic electron spin resonance (ESR) signal at a greater rate than those from MHR pigs. Increased formation in the incubations of thiobarbituric acid reactive substances (TBARS) by the microsomes of the MHS pigs indicated an enhanced susceptibility to free radical-mediated lipid peroxidation. These results provide further evidence that MHS pigs have an antioxidant abnormality which may contribute to the fatal MH response. However the nature of the abnormality is unclear. The enhanced formation of unstable free radicals and indices of lipid peroxidation was not due to decreased vitamin E concentration or glutathione peroxidase activity in the microsomes. Furthermore, fatty acid profiles were similar in microsomes from MHS and MHR pigs indicating similar amounts of potential substrate for TBARS formation.
The Photovoltaic Engineering Testbed: Design options and trade-offs (2000)

The Photovoltaic Engineering Testbed (PET) is a space-exposure test facility to fly on the International Space Station to calibrate, test, and qualify advanced solar cell types in the space environment. The purpose is to reduce the cost of validating new technologies and bringing them to spaceflight readiness by measuring them in the in-space environment. This paper reviews engineering options considered for flying PET on the International Space Station, and presents the current status of development.
Size-controlled synthesis of β-Co(OH)<SUB align="right">2 hexagonal nanoplates and their conversion into CoO octahedrons using cobalt naphthenate under solvothermal conditions (2012)

β–Co(OH)2 hexagonal nanoplates with a size range from 300 nm to 3 μm have been synthesised successfully by a template and surfactant–free solvothermal route in a very simple system composed only of water, LiOH and cobalt naphthenate in xylene solution. This method is high–yield, simple and environmentally benign. The as–obtained Co(OH)2 hexagonal nanoplates can be easily converted into CoO octahedrons with the size of 15 μm by increasing reaction temperature.
Über Additionsreaktionen von zinnorganischen Verbindungen mit N.N′ -Bis(pentafluorphenyl)-sehwefeldiimid / Addition Reactions of Tinorganic Compounds with N,N′-Bis(pentafluorophenyl)sulfurdiimide (1979)

Abstract The reactions of N,N′ -bis(pentafluorophenyl)sulfurdiimide with [(CH 3 ) 3 Sn] 2 NCH 3 , [(CH 3 )3Sn] 3 N and [(CH 3 ) 3 Sn] 2 NC 6 F 5 yiels the 1:1 adducts 1-3. 1 H and 19 F NMR investigations show, that fluorine atoms in the ortho position of the phenyl ring coordinate to the tin atom. This causes an increase of electron density at tin. A similar interpretation is given for the adduct 4 of N,N′-bis(p-chlorophenylsulfonyl)sulfurdiimide and [(CH 3 ) 3 Sn] 2 NCH 3 , where an oxygen atom of the sulfonyl group is bonded to tin.
Generalized Network Control Automation YANG Model (2019)

This document describes a YANG data model for the Generalized Network
Control Automation (GNCA), aimed to define an abstract and uniform
semantics for NETCONF/YANG scripts in the form of Event-Condition-
Action (ECA) containers.
X-ray Biological Dosimetry Performed by Selective Painting of Human Chromosomes 1 and 2 (1995)

Fluorescence in situ hybridization with a cocktail of whole-chromosome probes, specific for human chromosomes 1 and 2, was performed to analyze the induction of translocations and dicentrics in human peripheral blood lymphocytes exposed to 100 KVp X-rays and cultured for 48 h. The dose-response curves for both aberration types were linear-quadratic, with similar coefficients, and after correction for genome content were a little lower than the dose-response curve for dicentrics established by conventional analysis. Three doses were also assessed after 76-h culture. The dicentric yield at 76 h was reduced compared with that at 48 h because of the existence of second and third division metaphases. The translocation yield did not reduce except at 4 Gy. The frequency of cells containing both dicentrics and translocations suggested that their occurrence is not correlated. The importance of stating the scoring criteria and of specifying the different types of aberrations is stressed.
Pulse Pressure–Related Changes in Coronary Flow In Vivo Are Modulated by Nitric Oxide and Adenosine (1996)

Acute increases in arterial pulsatile load imposed on the left ventricle can increase coronary flow without commensurate changes in myocardial oxygen consumption. One explanation is that augmenting pulsatile perfusion at the same mean pressure itself stimulates flow by releasing endothelium-mediated vasorelaxant factors such as NO. The present study tested this hypothesis and determined whether NO and adenosine modulate this response. In open-chest anesthetized dogs, the distal left anterior descending coronary artery (LAD) was whole-blood-perfused by a novel servopump system to control mean and pulsatile perfusion pressure within the isolated vascular bed. Central aortic pressure was measured, stored to computer memory, and then digitally modified (varying the pulse pressure [PP]) to generate a real-time servocommand that was still synchronous with ventricular contraction. Left heart workload was unchanged. LAD flow was measured before and after increasing the PP (to 60 to 100 mm Hg) from baselines of either 0 or 40 mm Hg. With normal basal coronary vascular tone, raising the PP increased flow (+9 +/- 2% at a PP of 100 mm Hg). This response was markedly amplified (+39 +/- 8%) when basal tone was first partially reduced by adenosine. Competitive inhibition of NO synthase by N omega-monomethyl-L-arginine reduced acetylcholine and PP-dependent flow responses by 50%. Thus, enhanced pulsatile perfusion increases in vivo coronary flow in part by triggering NO release. The marked augmentation of the PP response with reduced basal coronary tone from adenosine suggests that this mechanism may play a role in improving myocardial perfusion during exercise.
High velocity atomic oxygen/surface accommodation studies (1991)

This paper provides the first experimental evaluation of the energy-accommodation coefficients of 8km/s oxygen atoms on selected materials. Preliminary measurements have been provided for three materials at normal incidence. Neglecting chemical energy, the accommodation coefficients for Ni, Au, and reaction-cured glass are approximately 0.6 +/- 50 percent.
Oxidative Regulation of Large Conductance Calcium-Activated Potassium Channels (2001)

Reactive oxygen/nitrogen species are readily generated in vivo, playing roles in many physiological and pathological conditions, such as Alzheimer's disease and Parkinson's disease, by oxidatively modifying various proteins. Previous studies indicate that large conductance Ca(2+)-activated K(+) channels (BK(Ca) or Slo) are subject to redox regulation. However, conflicting results exist whether oxidation increases or decreases the channel activity. We used chloramine-T, which preferentially oxidizes methionine, to examine the functional consequences of methionine oxidation in the cloned human Slo (hSlo) channel expressed in mammalian cells. In the virtual absence of Ca(2+), the oxidant shifted the steady-state macroscopic conductance to a more negative direction and slowed deactivation. The results obtained suggest that oxidation enhances specific voltage-dependent opening transitions and slows the rate-limiting closing transition. Enhancement of the hSlo activity was partially reversed by the enzyme peptide methionine sulfoxide reductase, suggesting that the upregulation is mediated by methionine oxidation. In contrast, hydrogen peroxide and cysteine-specific reagents, DTNB, MTSEA, and PCMB, decreased the channel activity. Chloramine-T was much less effective when concurrently applied with the K(+) channel blocker TEA, which is consistent with the possibility that the target methionine lies within the channel pore. Regulation of the Slo channel by methionine oxidation may represent an important link between cellular electrical excitability and metabolism.
Localization of buried objects through higher order statistics techniques (2003)

Underwater object localization is of great interest for a few years to acousticians (detection of boulders), marines (detection of buried mines), or archaeologists (detection of wreckage). Image and signal processing succeed in localizing objects lying on the sea bottom [J.A. Sunde, 1999], however localization of an object buried in sediment remains complex. The objective of this work is to propose a complete localization of objects buried in the sediment using high resolution techniques. A source which has many advantages (high relative bandwidth, narrow beam) and which are useful for object detection is used. This paper introduces a new algorithm for estimating the wide band parameters that is based on the high order statistics of the received signals with an aim of eliminating the Gaussian components from the signals received on the various hydrophones. In fact the noise of sea bottom is regarded as being Gaussian as well as the reverberations of the marine sediment. The performance of the proposed algorithm is studied on the real data recorded during underwater acoustic experiments.
Effects of Cooling Rate and Direct Hot Deformation Conditions after Solidification on the Austenitic Microstructure Evolved by Simulated Strip Casting and Thin Slab Casting Processes in HSLA Steels (2006)

Currently new continuous casting processes such as thin slab caster or strip casting are industrialized or under developing in the world steel makers. In these casting processes, cooling rate after solidification becomes much faster compared with thick slab caster, and hot rolling mill connected directly with casting machine tends to be installed. The present study was conducted to investigate variations of austenitic grain size and micro segregation with cooling rate after solidification and also direct hot deformation conditions in austenite immediately after solidification in HSLA steels. HSLA steels were 0.15%C-0.25%Si-1.50%Mn, 0.028%Nb and 0.028%Nb-0.015%Ti with the same basic compositions. A hot working simulator of THERMECMASTER-Z was used, and the center part of tensile specimen set up in this machine was partially or fully levitation-melted by induction heating under argon gas atmosphere. After melting, specimens were cooled at cooling rate from 0.4K/s to 40K/s, and this range covered cooling rates after solidification in heavy thick slab caster and strip casting. Direct hot tensile straining in austenite after solidification was conducted at strain rates from 1.4×10-3s-1 to 2.6s-1, corresponding to an extracting speed in a respective caster. The increase of cooling rate refined continuously as cast austenitic grain size, and it was enhanced in micro alloyed steels. Micro segregation such as Mn was improved by faster cooling. Direct straining after solidification markedly refined austenitic grain size through dynamic or static recrystallization occurring depending on strain rate.
TP53 and MTOR crosstalk to regulate cellular senescence (2010)

The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversible senescence, thereby adding yet another level of complexity to the signaling network that emanate from TP53.
Novel cycloadditions of isoquinoline Reissert salts (1993)

Isoquinoline Reissert salts 5 partake in novel cycloadditions with acetylenic aldehydes 11 giving novel oxazoles 14 which have been characterised by X-ray crystallography. In contrast, closely related phthalazine Reissert salts 6 and phenanthridine Reissert salts 15 react by an alternative pathway giving pyrrolo[2,1-a]phthalazines 12 and pyrrolo[1,2-f]phenanthridines 16 respectively.
PUFMon: Security monitoring of FPGAs using physically unclonable functions (2017)

Mainstream FPGAs and programmable SoCs employ different countermeasures during configuration and runtime to mitigate physical attacks. However, it has been demonstrated that sophisticated active attack techniques, such as laser voltage probing, can still bypass the bitstream protections during the configuration phase. On the other hand, although the security monitoring IP cores provided by FPGA vendors can ensure the physical security during the runtime of applications, they are unable to detect such attacks during configuration. In this work, we propose a novel approach to using PUFs as physical sensors to monitor the integrity of FPGAs against active attacks. Small modifications in existing PUF architectures enable us to design a PUF-based security scheme, which can be deployed for integrity monitoring and authentication/key generation at the same time. We evaluate the effectiveness of our framework against a range of powerful attacks, such as optical probing and fault attacks. We further discuss how this scheme can be deployed during bitstream configuration in FPGAs with partial reconfiguration capability.
Distinct subcellular localization in the cytosol and apicoplast, unexpected dimerization and inhibition of <i>Plasmodium falciparum</i> glyoxalases (2010)

The ubiquitous glyoxalase system removes methylglyoxal as a harmful by-product of glycolysis. Because malaria parasites have drastically increased glycolytic fluxes, they could be highly susceptible to the inhibition of this detoxification pathway. Here we analysed the intracellular localization, oligomerization and inhibition of the glyoxalases from Plasmodium falciparum. Glyoxalase I (GloI) and one of the two glyoxalases II (cGloII) were located in the cytosol of the blood stages. The second glyoxalase II (tGloII) was detected in the apicoplast pointing to alternative metabolic pathways. Using a variety of methods, cGloII was found to exist in a monomer-dimer equilibrium that might have been overlooked for homologues from other organisms and that could be of physiological importance. The compounds methyl-gerfelin and curcumin, which were previously shown to inhibit mammalian GloI, also inhibited P. falciparum GloI. Inhibition patterns were predominantly competitive but were complicated because of the two different active sites of the enzyme. This effect was neglected in previous inhibition studies of monomeric glyoxalases I, with consequences for the interpretation of inhibition constants. In summary, the present work reveals novel general glyoxalase properties that future research can build on and provides a significant advance in characterizing the glyoxalase system from P. falciparum.