gebhart/patrepeval huggingface dataset:
The dual role of p55 tumour necrosis factor-α receptor in<i>Actinobacillus actinomycetemcomitans</i>-induced experimental periodontitis: host protection and tissue destruction (2006)

Inflammatory immune reactions in response to periodontopathogens are thought to protect the host against infection, but may trigger periodontal destruction. Thus, we examined the mechanisms by which the proinflammatory cytokine tumour necrosis factor (TNF)-alpha modulates the outcome of Actinobacillus actinomycetemcomitans-induced periodontal disease in mice. Our results showed that TNF-alpha receptor p55-deficient mice [p55TNF-knock-out (KO)] developed a less severe periodontitis in response to A. actinomycetemcomitans infection, characterized by significantly less alveolar bone loss and inflammatory reaction. Real-time polymerase chain reaction (PCR) demonstrated that levels of chemokines (CXCL1, 3 and 10; CCL3 and 5) and their receptors (CXCR2 and 3, CCR5) were lower in p55TNF-KO mice, as were matrix metalloproteinase (MMP)-1, 2 and 9 and receptor activator of nuclear factor kB ligand (RANKL) mRNA levels. However, the absence of the TNF-alpha p55 results in an impairment of protective immunity to A. actinomycetemcomitans infection, characterized by increased bacterial load and higher levels of C-reactive protein during the course of disease. Such impaired host response may be the result of the reduced chemoattraction of lymphocytes, neutrophils and macrophages, and reduced inducible nitric oxide synthase expression (iNOS) and myeloperoxidase (MPO) production in periodontal tissues of p55 TNF-KO mice. Our results demonstrate the mechanisms involved determining periodontal disease severity by TNF-alpha receptor p55, and its role in providing immune protection to A. actinomycetemcomitans periodontal infection.
Strong Convergence Theorems of Viscosity Iterative Algorithms for Split Common Fixed Point Problems (2018)

In this paper, we propose a viscosity approximation method to solve the split common fixed point problem and consider the bounded perturbation resilience of the proposed method in general Hilbert spaces. Under some mild conditions, we prove that our algorithms strongly converge to a solution of the split common fixed point problem, which is also the unique solution of the variational inequality problem. Finally, we show the convergence and effectiveness of the algorithms by two numerical examples.
Neural network state estimation for full quantum state tomography (2018)

An efficient state estimation model, neural network estimation (NNE), empowered by machine learning techniques, is presented for full quantum state tomography (FQST). A parameterized function based on neural network is applied to map the measurement outcomes to the estimated quantum states. Parameters are updated with supervised learning procedures. From the computational complexity perspective our algorithm is the most efficient one among existing state estimation algorithms for full quantum state tomography. We perform numerical tests to prove both the accuracy and scalability of our model.
Error Probabilities for Telegraph Signals Transmitted on a Fading FM Carrier (1960)

This paper presents an analysis of error probabilities for multiplexed binary telegraph signals that are used to frequencymodulate an RF carrier that is subsequently corrupted by fading and noise. Frequency-shift keying, amplitude keying, and phase-shift keying are considered. It is shown that most telegraph errors occur when the carrier fades below threshold, and the principal results of the study therefore concern the effects of the FM threshold on error rate. Various methods of diversity reception are considered. For a maximal-ratio baseband combiner and certain types of telegraph receiver, a method is given for extending the results obtained for a single receiver to nth-order diversity. This makes it possible to use experimental data to describe either the threshold or the fading of the carrier. Study of threshold models indicates a serious conflict between the requirements of telephone channels and those of telegraph channels. Furthermore, good telegraph performance demands great care in the design of diversity combiners to work below threshold. The analysis pertains most directly to troposcatter systems, but the general conclusions regarding the effect of FM threshold should be relevant also for fading transmission paths such as those met in line-of-sight and telemetry.
Combining Words and Speech Prosody for Automatic Topic Segmentation (1999)

We present a probabilistic model that uses both prosodic and lexical cues for the automatic segmentation of speech into topic units. The approach combines hidden Markov models, statistical language models, and prosody-based decision trees. Lexical information is obtained from a speech recognizer, and prosodic features are extracted automatically from speech waveforms. We evaluate our approach on the Broadcast News corpus, using standard evaluation metrics. Results show that the prosodic model alone outperforms the word-based segmentation method. Furthermore, we achieve an additional reduction in error by combining the prosodic and wordbased knowledge sources. 1. Introduction Topic segmentation deals with the problem of automatically dividing a stream of text or speech into topically homogeneous blocks [1]. That is, given a sequence of (written or spoken) words, the aim is to find the boundaries where topics change. Topic segmentation is an important task for various language understan...
Adhesion and Dispersion of Salmeterol Xinafoate from Lactose Interactive Mixtures for Inhalation - Can Surface Roughness of Carriers Determine Performance (2009)

The objective was to understand the influence of the surface roughness of lactose carriers on the adhesion and dispersion of salmeterol xinafoate (SX) from interactive mixtures. The surface roughness of lactose carriers was determined by confocal microscopy. Particle images and adhesion forces between SX and lactose particles were determined by Atomic Force Microscopy. The dispersion of SX (2.5%) from interactive mixtures with lactose was determined using a twin-stage impinger (TSI) with a Rotahaler(r) at an airflow rate of 60L/min. SX was analysed using a validated HPLC assay. The RMS Rq of lactose carriers ranged from 0.93-2.84micrometers, the Fine Particle Fraction (FPF) of SX ranged between 4 and 24 percent and average adhesion force between a SX and lactose particles ranged between 49 and 134 nN. No direct correlation was observed between the RMS Rq of lactose carriers and either the FPF of SX for the interactive mixtures or the adhesion force of a SX on the lactose particles; however, the presence of fine lactose associated with the carrier surface increased the FPF of SX. Dispersion through direct SX detachment from the carrier surface was not consistent with the poor correlations described and was more likely to occur through complex particulate interactions involving fine lactose.
Current advances in Phi29 pRNA biology and its application in drug delivery (2012)

Bacteriophage 29 (Phi29) packaging RNA (pRNA) is one of the key components in the viral DNA-packaging motor. It contains two functional domains facilitating the translocation of DNA into the viral capsid by interacting with other elements in the motor and promoting adenosine triphosphates hydrolysis. Through the connection between interlocking loops in adjacent pRNA monomers, pRNA functions in the form of multimer ring in the motor. Previous studies have addressed the unique structure and conformation of pRNA. However, there are different DNA-packaging models proposed for the viral genome transportation mechanism. The DNA-packaging ability and the unique features of pRNA have been attracting efforts to study its potential applications in nanotechnology. The pRNA has been proved to be a promising tool for delivering nucleic acid-based therapeutic molecules by covalent linkage with ribozymes, small interfering RNAs, aptamers, and artificial microRNAs. The flexibility in constructing dimers, trimers, and hexamers enables the assembly of polyvalent nanoparticles to carry drug molecules for therapeutic purposes, cell ligands for target delivery, image detector for drug entry monitoring, and endosome disrupter for drug release. Besides these fascinating pharmacological advantages, pRNA-based drug delivery has also been demonstrated to prolong the drug half life with minimal induction of immune response and toxicity.
Beam Steering for the Misalignment in UCA-Based OAM Communication Systems (2018)

Radio frequency-orbital angular momentum (RF-OAM) is a technique that provides extra degrees of freedom to improve spectrum efficiency of wireless communications. However, OAM requires perfect alignment of the transmit and the receive antennas and this harsh precondition greatly challenges practical applications of RF-OAM. In this letter, we first investigate the effect of non-parallel misalignment on the channel capacity of the RF-OAM communication system equipped with uniform circular array. Then, we propose a transmit/receive beam steering approach to circumvent the large performance degradation in not only non-parallel case, but also off-axis and other general misalignment cases. The effectiveness of the beam steering approach is validated through both mathematical analysis and numerical simulations.
Effect of Cultivar and Environment on Seed Yield in Alfalfa (2002)

Seed yield of alfalfa (Medicago sativa L.) is important in determining the effective distribution of new cultivars to farmers. Many genetic and environmental factors affect seed yield. This study was conducted to explain seed yield variation induced by either environmental conditions or cultivars. We analyzed seed yield, aboveground phytomass, harvest index, and seed yield components for a set of 12 cultivars at four locations across France in each of three years. Each location x year combination was considered an environment. Seed weight, number of pods per inflorescence, number of seeds per pod, and mean seed weight were measured. Mean seed yield was 801 kg ha(-1). Large variation in seed yield was found among cultivars and environments. The cultivar x environment interaction was significant. Among environments, seed yield was highly correlated with aboveground phytomass at harvest (r = 0.94) as the lowest seed yields were obtained in the seeding year. The cultivars most adapted to grazing showed the lowest seed yields. Seed yield was genetically correlated with lodging resistance (r = -0.89) and harvest index (r = 0.99). The mean harvest index was 12.7%. The seed weight per inflorescence showed a high broad-sense heritability (0.58) and a high genetic correlation with seed yield (r = 0.91) and with harvest index (r = 0.96). Variation in seed weight per inflorescence was associated with variation in the number of seeds per pod and number of pods per inflorescence. Seed weight per inflorescence appears to have a strong genetic association with seed yield in alfalfa. Environments with high aboveground phytomass potential also have high seed yield potential.
Towards an Electronic Medical Record (1995)

McDonnell Information Systems, Adelaide SA. McDonnell Information Systems is bringing together its considerable international experience of health care; the vision of a wide cross section of clinicians from Australia and New Zealand and state-of-the-art development tools, to produce a new level of functionality in a clinically-driven integrated health care information system HealthCare 2000. Over phased development, the product will supply all facets of clinical information, medical charting, and patient care resource booking, to support the information requirements of the Health industry. The accumulation, storage, and retrieval of this data will replace the requirements of the paper record in the longer term.
Resource-Efficient Routing and Scheduling of Time-Constrained Network-on-Chip Communication (2006)

Network-on-chip-based multiprocessor systems-on-chip are considered as future embedded systems platforms. One of the steps in mapping an application onto such a parallel platform involves scheduling the communication on the network-on-chip. This paper presents different scheduling strategies that minimize resource usage by exploiting all scheduling freedom offered by networks-on-chip. Our experiments show that resource-utilization is improved when compared to existing techniques
Crucial role of the melanocortin receptor MC1R in experimental colitis (2006)

This is the first study to show a functional role of MC1R in intestinal inflammation. The data suggest a pivotal role of non-haematopoietic cell expressed MC1R in the host's response to pathogenic stimuli.
Optimization of novel high-power millimeter-wave TM/sub 01/-TE/sub 11/ mode converters (1997)

In this paper, a numerical study of direct TM/sub 01/-TE/sub 11/ mode converters in highly overmoded, bent smooth, circular waveguides is presented for high-power millimeter waves. The various shapes of bent waveguides are elaborately chosen, and their optimized geometrical dimensions have been achieved with a general optimization code employing the coupled mode theory. The mode converters designed can have high conversion efficiencies over 98% and wide bandwidths of 28%.
3D Printing of Resin Material for Denture Artificial Teeth: Chipping and Indirect Tensile Fracture Resistance (2018)

3D printing of denture artificial teeth with resin materials is worthy of study in a novel way. This study evaluated chipping and indirect tensile fracture resistance of 3D printing resin material (Dentca 3D printing denture teeth resin) compared with conventionally prefabricated resin denture teeth (Premium-8, Surpass, SR-Orthosit-PE, and Preference). One hundred tooth specimens were prepared for testing. The 3D printed tooth specimens were printed at a 50 µm layer thickness with methacrylate-based photopolymerized resin by stereolithography 3D printing. Chipping and indirect tensile fracture tests were conducted at a speed of 1 mm/min until fracture. The indirect tensile fracture loads of the 3D printed resin teeth were higher than those of Premium-8, Surpass, and SR-Orthosit-PE, and lower than those of Preference teeth. Regarding chipping resistance, the 3D printed resin teeth were not different from Surpass and SR-Orthosit-PE, and were lower than Premium-8 and Preference teeth. The 3D printed resin teeth exhibited vertical fracture of the loaded cusp without deformation in chipping. The 3D printed resin teeth showed simultaneous fracture of two cusps in indirect tensile fracture, unlike other teeth. The results of this study suggest that 3D printing technology using resin materials provides adequate fracture resistance for denture artificial tooth use.
d-Serine Dehydratase from Escherichia coli (1972)

Abstract d-Serine dehydratase from Escherichia coli has two distinct binding sites for pyridoxal 5'-phosphate; a high affinity site (Kdiss 0.03 µm) which binds the catalytically essential coenzyme and a low affinity site (Kdiss near 1000 µm) which binds pyridoxal-P, pyridoxal, or 5-deoxypyridoxal approximately equally, with resultant inhibition of enzymatic activity. Following borohydride reduction, carboxymethylation and chymotryptic digestion of the holoenzyme, a single non-apeptide containing the N6-pyridoxyllysine residue, and thus corresponding to a portion of the high affinity coenzyme binding site was isolated by two different chromatographic procedures and shown to have the sequence: Ser-(Pxy)Lys-Gly-Arg-Ile-Asn-Lys-Ala-Thr. The peptide differs from the corresponding coenzyme-binding site peptides isolated from other pyridoxal-P-dependent enzymes in its highly basic and relatively hydrophilic character. When borohydride reduction of d-serine holodehydratase was carried out in the presence of an inhibitory concentration (7.5 mm) of pyridoxal-P, one additional major pyridoxylpeptide, corresponding to a portion of the low affinity pyridoxal-binding site was isolated. The sequence of this inhibitory site peptide was determined to be: Val-(Pxy)Lys-Ala-Gly-Ala-Phe.
Characterization of monoclonal antibodies against apolipoprotein B (1986)

Conference Article| April 01 1986 Characterization of monoclonal antibodies against apolipoprotein B DEIRDRE BREEN; DEIRDRE BREEN *Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland†National Institute for Higher Education, Glasnevin, Dublin 9, Ireland Search for other works by this author on: This Site PubMed Google Scholar RICHARD O'KENNEDY; RICHARD O'KENNEDY †National Institute for Higher Education, Glasnevin, Dublin 9, Ireland Search for other works by this author on: This Site PubMed Google Scholar FRANK HALLINAN FRANK HALLINAN *Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland‡College of Technology, Kevin Street, Dublin 8, Ireland Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1986) 14 (2): 475–476. https://doi.org/10.1042/bst0140475 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation DEIRDRE BREEN, RICHARD O'KENNEDY, FRANK HALLINAN; Characterization of monoclonal antibodies against apolipoprotein B. Biochem Soc Trans 1 April 1986; 14 (2): 475–476. doi: https://doi.org/10.1042/bst0140475 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1986 Biochemical Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.
Coming out is act of courage (2002)

I was sorry to read Phil Barker’s facile comment concerning the ‘fashionable’ nature of revealing oneself to be a professional sufferer of mental illness (MHP 5, 5, 26- 28). In my experience, the decision to reveal the truth of such a situation is never made lightly. Without meaning to detract from the courage shown by Annie Altschul, the same act made by nurses, without the protection of celebrity, shows their own form of courage.
Books (1980)

Journal Article Books Get access Hucbald, Guido, and John on Music Translated by Warren Babb; edited, with introductions, by Claude V. Palisca; index of chants by Alejandro Enrique Planchart Yale University Pres, New Haven and London, 1978, £12.60 CHRISTOPHER PAGE CHRISTOPHER PAGE Search for other works by this author on: Oxford Academic Google Scholar Early Music, Volume 8, Issue 1, January 1980, Pages 94–95, https://doi.org/10.1093/earlyj/8.1.94 Published: 01 January 1980
Multi-robot task allocation: analyzing the complexity and optimality of key architectures (2004)

Important theoretical aspects of multi-robot coordination mechanisms have, to date, been largely ignored. To address part of this negligence, we focus on the problem of multi-robot task allocation. We give a formal, domain-independent, statement of the problem and show it to be an instance of another, well-studied, optimization problem. In this light, we analyze several recently proposed approaches to multi-robot task allocation, describing their fundamental characteristics in such a way that they can be objectively studied, compared, and evaluated.
Attenuation of seismic waves in dry and saturated rocks; I, Laboratory measurements (1979)

Abstract The attenuation of compressional (P) and shear (S) waves in dry, saturated, and frozen rocks is measured in the laboratory at ultrasonic frequencies. A pulse transmission technique and spectral ratios are used to determine attenuation coefficients and quality factor (Q) values relative to a reference sample with very low attenuation. In the frequency range of about 0.1-1.0 MHz, the attenuation coefficient is linearly proportional to frequency (constant Q) both for P- and S-waves. In dry rocks, Q p of compressional waves is slightly smaller than Q s of shear waves. In brine and water-saturated rocks, Q p is larger than Q s . Attenuation decreases substantially (Q values increase) with increasing differential pressure for both P- and S-waves.
Concept-Driven Multi-Modality Fusion for Video Search (2011)

As it is true for human perception that we gather information from different sources in natural and multi-modality forms, learning from multi-modalities has become an effective scheme for various information retrieval problems. In this paper, we propose a novel multi-modality fusion approach for video search, where the search modalities are derived from a diverse set of knowledge sources, such as text transcript from speech recognition, low-level visual features from video frames, and high-level semantic visual concepts from supervised learning. Since the effectiveness of each search modality greatly depends on specific user queries, prompt determination of the importance of a modality to a user query is a critical issue in multi-modality search. Our proposed approach, named concept-driven multi-modality fusion (CDMF), explores a large set of predefined semantic concepts for computing multi-modality fusion weights in a novel way. Specifically, in CDMF, we decompose the query-modality relationship into two components that are much easier to compute: query-concept relatedness and concept-modality relevancy. The former can be efficiently estimated online using semantic and visual mapping techniques, while the latter can be computed offline based on concept detection accuracy of each modality. Such a decomposition facilitates the need of adaptive learning of fusion weights for each user query on-the-fly, in contrast to the existing approaches which mostly adopted predefined query classes and/or modality weights. Experimental results on TREC video-retrieval evaluation 2005-2008 dataset validate the effectiveness of our approach, which outperforms the existing multi-modality fusion methods and achieves near-optimal performance (from oracle fusion) for many test queries.
Chemical Composition and Seasonal Variations of Spike Lavender Oil from Southern Spain (2004)

Abstract The composition of six essential oil samples, obtained by steam distillation of twigs of spike lavender (Lavandula latifolia Med.) harvested in three different locations from southern Spain during the full flowering and fruiting phenological stages, has been analyzed by capillary GC and GC/MS in combination with retention indices. Yields of the oils during flowering (1.5–2.2%) were 2.5–7 times higher than during fruiting (0.3–0.6%). Among the 56 identified constituents (accounting for 96.0–97.5% of the oils), the main and characteristic components were linalool (27.2–43.1%), 1,8-cineole (28.0–34.9%), camphor (10.8–23.2%), borneol (0.9–3.6%), β-pinene (0.8–2.6%), (E)-α-bisabolene (0.5–2.3%), β-pinene (0.6–1.9%), β-caryophyllene (0.5–1.9%), α-terpineol (0.8–1.6%), sabinene (0.3–0.8%), myrcene (0.3–0.8%), camphene (0.4–0.6%), terpinen-4-ol (0.3–0.5%) and limonene (0.2–0.9%). The volatile chemical composition and oil production of both full flowering and fruiting plants allowed to assess the type and quality of the spike lavender oils processed in the studied area.
Learning to love rejection (2013)

In my career, I've published a great many articles and books. What most of my colleagues don't know is that I've had lots of rejections too - hundreds of them.\nRejections are a dirty secret among academics. Publication successes are cause for celebration, or at least a proud listing on CVs and departmental lists. Failures - rejected papers and unsuccessful grant and promotion applications - are usually hidden and sometimes a source of shame. The result is that many scholars, especially junior ones, have unrealistic expectations. For this reason Donald Hall, in his book The Academic Self, recommends that experienced academics tell more about their failures, as encouragement to others not to give up.