gebhart/patrepeval huggingface dataset:
Random-Accessible Compressed Triangle Meshes (2007)

With the exponential growth in size of geometric data, it is becoming increasingly important to make effective use of multilevel caches, limited disk storage, and bandwidth. As a result, recent work in the visualization community has focused either on designing sequential access compression schemes or on producing cache-coherent layouts of (uncompressed) meshes for random access. Unfortunately combining these two strategies is challenging as they fundamentally assume conflicting modes of data access. In this paper, we propose a novel order-preserving compression method that supports transparent random access to compressed triangle meshes. Our decompression method selectively fetches from disk, decodes, and caches in memory requested parts of a mesh. We also provide a general mesh access API for seamless mesh traversal and incidence queries. While the method imposes no particular mesh layout, it is especially suitable for cache-oblivious layouts, which minimize the number of decompression I/O requests and provide high cache utilization during access to decompressed, in-memory portions of the mesh. Moreover, the transparency of our scheme enables improved performance without the need for application code changes. We achieve compression rates on the order of 20:1 and significantly improved I/O performance due to reduced data transfer. To demonstrate the benefits of our method, we implement two common applications as benchmarks. By using cache-oblivious layouts for the input models, we observe 2?6 times overall speedup compared to using uncompressed meshes.
Fused Matrix Factorization with Geographical and Social Influence in Location-Based Social Networks (2021)

Recently, location-based social networks (LBSNs), such as Gowalla, Foursquare, Facebook, and Brightkite, etc., have attracted millions of users to share their social friendship and their locations via check-ins. The available check-in information makes it possible to mine users’ preference on locations and to provide favorite recommendations. Personalized Point-of-interest (POI) recommendation is a significant task in LBSNs since it can help targeted users explore their surroundings as well as help third-party developers to provide personalized services. To solve this task, matrix factorization is a promising tool due to its success in recommender systems. However, previously proposed matrix factorization (MF) methods do not explore geographical influence, e.g., multi-center check-in property, which yields suboptimal solutions for the recommendation. In this paper, to the best of our knowledge, we are the first to fuse MF with geographical and social influence for POI recommendation in LBSNs. We first capture the geographical influence via modeling the probability of a user’s check-in on a location as a Multi-center Gaussian Model (MGM). Next, we include social information and fuse the geographical influence into a generalized matrix factorization framework. Our solution to POI recommendation is efficient and scales linearly with the number of observations. Finally, we conduct thorough experiments on a large-scale real-world LBSNs dataset and demonstrate that the fused matrix factorization framework with MGM utilizes the distance information sufficiently and outperforms other state-of-the-art methods significantly.
Nonlinear Moving Horizon Observer for Estimation of States and Parameters in Under-Balanced Drilling Operations (2014)

It is not possible to directly measure the total mass of gas and liquid in the annulus and geological properties of the reservoir during petroleum exploration and production drilling. Therefore, these parameters and states must be estimated by online estimators with proper measurements. This paper describes a nonlinear Moving Horizon Observer to estimate the annular mass of gas and liquid, and production constants of gas and liquid from the reservoir into the well during Under-Balanced Drilling with measuring the choke pressure and the bottom-hole pressure. This observer algorithm based on a low-order lumped model is evaluated against Joint Unscented Kalman filter for two different simulations with low and high measurement noise covariance. The results show that both algorithms are capable of identifying the production constants of gas and liquid from the reservoir into the well, while the nonlinear Moving Horizon Observer achieves better performance than the Unscented Kalman filter.
Targeting PD-L1 in non-small cell lung cancer using CAR T cells (2020)

Antibodies against programmed cell death protein 1 (PD-1) and its ligand (PD-L1) have dramatically changed the landscape of therapies for non-small cell lung carcinoma (NSCLC); however, the majority of patients do not respond to these agents. In addition, hyperprogressive disease (HPD) develops in a larger portion of NSCLC patients treated with PD-1/PD-L1 inhibitors than in patients treated with standard chemotherapy. The use of chimeric antigen receptor (CAR) T cells has been successful to treat blood cancers but not for solid tumors like NSCLC. In this work, we constructed CAR T cells that target PD-L1 and evaluated their efficacy in NSCLC with either high or low PD-L1 expression. PD-L1-CAR T cells exhibited antigen-specific activation, cytokine production, and cytotoxic activity against PD-L1<sup>high</sup> NSCLC cells and xenograft tumors. Furthermore, the addition of a subtherapeutic dose of local radiotherapy improved the efficacy of PD-L1-CAR T cells against PD-L1<sup>low</sup> NSCLC cells and tumors. Our findings indicate that PD-L1-CAR T cells represent a novel therapeutic strategy for patients with PD-L1-positive NSCLC, particularly for those who are susceptible to HPD.
CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis (2020)

Vaccinex, Inc.; Regione Lombardia (TRANS-ALS).
Treatment,s study of hypercellular acute leukemia with HU based combination regimen (2010)

Objective To observe the effect of HU based combination regimen in the treatment and complication of patients with hypercellular acute leukemia. Methods 38 patients with hypercellular acute leukemia were divided into two groups,22 patients with hypercellular acute leukemia were treated by HU in combination regimen, 16 patients with hypercellular acute leukemia were treated dy combination regimen. Results The complete remission of 22 patients in treatmented group was 11 cases, the partial remission was 5 cases, nonremission of was 4 cases,2 patients were deathed. The complete remission of 16 patients in controlled was 6 cases, PR was 3 cases, NR was 4 cases,3 patients were deathed. the curative effect of the hypercell acute leukemia patients in betneen two groups Were the same ,P ＞ 0.05. The time of periphery blood white cell in chemotherapy was reduced under 10 × 109/L,the treatmented group was 4.63 ± 1.16 days,the control group was 6. 55 ± 1.97days, there was a significant difference between these two groups, P ＜ 0.01. Conclusion The hypercellular acute leukemia in based combination treatmented regimem was treated by HU, the leukemia cells were controlled quick and lasting, the cranial cavity bleeding and ARDS of hypercellular acute leukemia, s patients have reduced, for increasing the efficacy, improving pregnosis, and prolonging survivol time, the hypercellular acute leukemia are very important.

Key words: 
Hypercellular;  Acute leukemia;  HU;  Chemotherapy
High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer (2013)

Some Escherichia coli strains produce toxins designated cyclomodulins (CMs) which interfere with the eukaryotic cell cycle of host cells, suggesting a possible link between these bacteria and cancers. There are relatively few data available concerning the colonization of colon tumors by cyclomodulin- and genotoxic-producing E. coli. We did a qualitative and phylogenetic analysis of mucosa-associated E. coli harboring cyclomodulin-encoding genes from 38 patients with colorectal cancer (CRC) and 31 with diverticulosis. The functionality of these genes was investigated on cell cultures and the genotoxic activity of strains devoid of known CM-encoding gene was investigated. Results showed a higher prevalence of B2 phylogroup E. coli harboring the colibatin-producing genes in biopsies of patients with CRC (55.3%) than in those of patients with diverticulosis (19.3%), (p<0.01). Likewise, a higher prevalence of B2 E. coli harboring the CNF1-encoding genes in biopsies of patients with CRC (39.5%) than in those of patients with diverticulosis (12.9%), (p = 0.01). Functional analysis revealed that the majority of these genes were functional. Analysis of the ability of E. coli to adhere to intestinal epithelial cells Int-407 indicated that highly adherent E. coli strains mostly belonged to A and D phylogroups, whatever the origin of the strains (CRC or diverticulosis), and that most E. coli strains belonging to B2 phylogroup displayed very low levels of adhesion. In addition, 27.6% (n = 21/76) E. coli strains devoid of known cyclomodulin-encoding genes induced DNA damage in vitro, as assessed by the comet assay. In contrast to cyclomodulin-producing E. coli, these strains mainly belonged to A or D E. coli phylogroups, and exhibited a non significant difference in the distribution of CRC and diverticulosis specimens (22% versus 32.5%, p = 0.91). In conclusion, cyclomodulin-producing E. coli belonging mostly to B2 phylogroup colonize the colonic mucosa of patients with CRC.
Depression and Psychotherapy: The Importance of a Psychotherapeutic Approach Focused on Logical Reasoning and Functioning (2016)

Many patients who show up with depressive and anxious symptomology\nhave, or have had, interpersonal conflicts that triggered or contributed to the\naggravation of the symptomology herein explained. Clinical experience has\ntaught us that many people have difficulty in maintaining Faultless Logical\nReasoning (FLR) and, even if FLR is present, they have difficulty in maintaining\nFaultless Logical Functioning (FLF). In clinical practice, psychotherapists saw\npeople that in consequence of their difficulty in FLR/FLF involves in conflicts\nthat brought them interpersonal problems in relationships, in business, work,\nand in other areas of their life. Consequently, these problems will be followed by\nanxious and depressive symptomatology. Almost always, this symptomology is\naccompanied by intense emotional changes. With this clinical case of a patient\nwith depression, and its treatment, is demonstrated the importance to investigate\nthe capacity of patients to function and think, respectively, with FLF and FLR.\nThis work has proved very exciting because Logic-Based Psychotherapy (LBP)\nprovide pedagogy to think better, to improve emotional processing, introspection,\nand more profound and rigorous analysis and responses. If the responses of the\nsubject are more logical, it will result in fewer conflicts, less ill will, and fewer\ndisagreements, which will lead to fewer cases of depression.
Antifungal Hydrolases in Pea Tissue (1988)

Chitinase and β-1,-3-glucanase activities increased coordinately in pea (Pisum sativum L. cv “Dot”) pods during development and maturation and when immature pea pods were inoculated with compatible or incompatible strains of Fusarium solani or wounded or treated with chitosan or ethylene. Up to five major soluble, basic proteins accumulated in stressed immature pods and in maturing untreated pods. After separation of these proteins by chromatofocusing, an enzymic function could be assigned to four of them: two were chitinases and two were β-1,3-glucanases. The different molecular forms of chitinase and β-1,3-glucanase were differentially regulated. Chitinase Ch1 (mol wt 33,100) and β-1,3-glucanase G2 (mol wt 34,300) were strongly induced in immature tissue in response to the various stresses, while chitinase Ch2 (mol wt 36,200) and β-1,3-glucanase G1 (mol wt 33,500) accumulated during the course of maturation. With a simple, three-step procedure, both chitinases and both β-1,3-glucanases were purified to homogeneity from the same extract. The two chitinases were endochitinases. They differed in their pH optimum, in specific activity, in the pattern of products formed from [(3)H]chitin, as well as in their relative lysozyme activity. Similarly, the two β-1,3-glucanases were endoglucanases that showed differences in their pH optimum, specific activity, and pattern of products released from laminarin.
Finite control set MPC with high frequency injections for sensorless position and speed estimation of a PMSM (2015)

A new control algorithm for operation of surface mounted permanent magnet synchronous machines in very low speed and standstill using finite control set model predictive control (FCS-MPC) and high frequency signal injection for estimation of the rotor position is proposed. Estimation of the rotor position is based on the standard injections of high frequency signal into the voltage command for a PWM. It is intended to achieve the same effect using the FCS-MPC. The FCS-MPC usually operates with a short sampling period, therefore the estimation algorithm needs to be computationally cheap. Moreover, the cost function needs to be modified to secure injection of high frequency (hf) voltage signals into a given axis in a reference frame linked with the rotor position. In this paper, a method of injection of a harmonic signal using FCS-MPC is proposed, using an extension of the cost function. Rotor position and speed estimation is based on the conventional phase-locked loop. Theoretical assumptions are verified by both simulations and experiments on a laboratory prototype of PMSM drive with rated power of 250 W.
Estimation of local aortic elastic properties with MRI (2002)

Aortic compliance and pulse wave velocity (PWV) are important determiners of heart load, and are clinically useful indices of cardiovascular risk. Most direct methods to derive them require invasive pressure measurement. In this work a noninvasive technique to evaluate aortic compliance and PWV using MRI is proposed. MRI magnitude and phase images to measure area and flow in the ascending aorta were acquired in a group of 13 young healthy subjects. Assuming that the early systolic part of the wave was unidirectional and reflectionless, PWV was determined as the ratio between flow and area variations at early systole. Our results were compared to pulse wave velocities derived from a direct transit time, and to one using ascending aortic area and peripheral brachial pulse pressure. The new method proved to be accurate and in good agreement with the transit time method, as well as with previously published results.
Bolt-on causal consistency (2013)

We consider the problem of separating consistency-related safety properties from availability and durability in distributed data stores via the application of a "bolt-on" shim layer that upgrades the safety of an underlying general-purpose data store. This shim provides the same consistency guarantees atop a wide range of widely deployed but often inflexible stores. As causal consistency is one of the strongest consistency models that remain available during system partitions, we develop a shim layer that upgrades eventually consistent stores to provide convergent causal consistency. Accordingly, we leverage widely deployed eventually consistent infrastructure as a common substrate for providing causal guarantees. We describe algorithms and shim implementations that are suitable for a large class of application-level causality relationships and evaluate our techniques using an existing, production-ready data store and with real-world explicit causality relationships.
Karhunen-Loeve analysis of dynamic sequences of thermographic images for early breast cancer detection (2003)

The Karhunen-Loeve transform (KLT) is applied to the analysis of dynamic sequences of thermograms describing the temporal evolution of body surface temperature following the application of an external thermal stimulus. The KLT may be evaluated either along the spatial or temporal dimensions of the data; the duality of both representations is emphasized. An example is presented to illustrate that the KLT allows an efficient data reduction and facilities tumor detection by highlighting physiologically important abnormalities in the time behavior of thermal patterns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Interfacing Superconducting Qubits With Cryogenic Logic: Readout (2019)

As superconducting quantum processors increase in size and complexity, the scalability of standard techniques for qubit control and readout becomes a limiting factor. Replacing room temperature analog components with cryogenic digital components could allow for the realization of systems well beyond the current state-of-the-art qubit arrays with tens of qubits. The standard technique for performing a qubit measurement with heterodyne readout uses a quantum-limited cryogenic amplifier chain and requires bulky microwave components inside the refrigerator with multiple control lines and pump signals. Additionally, the result is only accessible in software at room temperature. An alternative method for measuring qubits involves mapping the qubit state onto the photon occupation in a microwave cavity, followed by subsequent photon detection using a Josephson photomultiplier (JPM). The JPM measures the qubit and stores the result in a classical circulating current. To make use of this result, we can leverage existing single flux quantum (SFQ) circuitry. An underdamped Josephson transmission line (JTL) can be coupled to the JPM and fluxons traveling along the JTL are accelerated or delayed, depending on the circulating current state of the JPM. This fluxon delay can then be converted to an SFQ logic signal resulting in a digital qubit readout with a proximal microfabricated device, paving the way for cryogenic digital feedback necessary for error-correcting codes.
Following Charge Separation on the Nanoscale in Cu<sub>2</sub>O–Au Nanoframe Hollow Nanoparticles (2011)

Cu(2)O-Au nanoframes with different nanolayer thicknesses of Cu(2)O were prepared, and their photocatalytic properties in aqueous solutions were studied. Cu(2)O semiconductor excitation leads to electron-hole separation. In aqueous solution, the hole is known to oxidize water to produce hydroxyl radicals whose concentration (and that of the holes) can be monitored by the rate of the degradation of dissolved methylene blue dye. The exciton lifetime is determined by femtosecond techniques and is determined by electron-hole recombination which depends on the rates of a number of competing processes such as, electron or hole transfer to an acceptor such as a gold nanoframe and/or the electron or hole trapping processes at the Cu(2)O-Au nanoframe interface. We measured the exciton lifetime as a function of the average Cu(2)O-Au layer separation. A good correlation was found between the rate of the photocatalytic degradation of methylene blue and the exciton lifetime. The exciton lifetime is found to increase as the Cu(2)O thickness is increased. This leads to an increase in the electron-hole separation time and thus an increase in the hole (and so the hydroxyl radical) concentration leading to an observed enhanced rate of the dye degradation.
Expression of Co-Stimulatory Molecules by Tumor Cells Decreases Tumorigenicity but May Also Reduce Systemic Antitumor Immunity (1996)

Many tumor cells do not express co-stimulatory molecules, and this may account, in part, for their poor ability to stimulate T cells directly. One strategy to enhance immune recognition would be to express such molecules on the tumor cell. Here, we show that expression of a member of the B7 family of co-stimulatory molecules by CMT93 murine colorectal tumor or 1735 murine melanoma cells resulted in a local antitumor response in immunocompetent mice. The antitumor effect was diminished in athymic nude mice, indicating that T cells played an important part in this response. The ability of the B7-expressing tumor cells to generate systemic protective immunity was investigated by excision of tumors that developed from the initial inoculation followed by rechallenge with parental tumor cells. CMT93 is a poorly immunogenic tumor and no significant systemic immunity was elicited by the expression of B7-1 in these cells. 1735 melanoma is a mildly immunogenic tumor. Unexpectedly, the systemic immunity obtained with 1735 tumors expressing B7-1 or B7-2 was weaker than that generated by parental 1735 cells (p < 0.001, stratified logrank test), even when coexpression of interferon-gamma in the B7-1 cells produced high levels of surface MHC class I expression. These results suggest that some caution is appropriate when considering the use of these molecules in the gene therapy of cancer.
Detection of outer membrane porin protein, an imipenem influx channel, in Pseudomonas aeruginosa clinical isolates. (2010)

Decreased permeability to imipenem is the most frequent mechanism of imipenem resistance in Pseudomonas aeruginosa. We have determined the presence of OprD porin protein, an imipenem influx channel, in 70 carbapenem-resistant P. aeruginosa clinical isolates by Western blot analysis using rabbit anti-OprD polyclonal antibody. Ninety-eight percent (54 of 55 isolates) of imipenem-and meropenem-resistant P. aeruginosa clinical isolates were negative for OprD porin production. A small group of isolates resistant to imipenem but susceptible to meropenem (2 isolates) produced OprD protein but at a level 3-5 times lower than the wild type P. aeruginosa ATCC27853 strains. This study indicates that the loss of OprD porin protein was the main mechanism for imipenem resistance in P. aeruginosa clinical isolates. Determination of the status of OprD level in P. aeruginosa may help in the better selection of appropriate carbapenem antibiotics.
Cloning and stable expression of the human mitochondrial cytochrome P45011B1 cDNA in V79 Chinese hamster cells and their application for testing of potential inhibitors (1995)

V79 Chinese hamster cells are being genetically engineered to express human mitochondrial cytochromes P450 as an analytical tool for studying adrenal steroid synthesis. Here, a V79 derived cell line is presented expressing the enzymatically active human cytochrome P45011B1 (CYP11B1) in a stable and constitutive manner. Full length CYP11B1 cDNA was obtained from surgically removed normal adrenal gland by polymerase chain reaction. The cDNA was recombined with a SV40 early promoter containing plasmid for stable integration and expression in V79 cells upon gene transfer. The presence of the human CYP11B1 cDNA in the genome of the transfected cells was confirmed by Southern analysis. CYP11B1 cDNA directed expression was detected by Northern analysis. CYP11B1 dependent hydroxylation of deoxycorticosterone and 11-deoxycortisol was measured by HPLC analysis. Interestingly, the nonsteroidogenic lung fibroblast derived V79 Chinese hamster cell line was able to support human CYP11B1 mediated steroid hydroxylation without simultaneous heterologous expression of the human electron transfer system, adrenodoxin, and adrenodoxin reductase. CYP11B1 inhibitory potency of metyrapone, spironolactone, and the azole derivatives ketoconazole, clotrimazole, miconazole, and fluconazole was measured using the newly established V79MZh11B1 cell line. Thus, beside steroid metabolism studies in general, this cell line may also serve as an in vitro tool for monitoring the interference of drugs with 11 beta-hydroxylase activity.