gebhart/patrepeval huggingface dataset:
Fabrication of anodically bonded capacitive micromachined ultrasonic transducers with vacuum-sealed cavities (2014)

Capacitive micromachined ultrasonic transducers (CMUTs) have demonstrated great promise for next-generation ultrasound technology. Wafer-bonding technology particularly simplifies the fabrication of CMUTs by eliminating the requirement for a sacrificial layer and increases control over device parameters. Anodic bonding has many advantages over other bonding methods such as low temperature compatibility, high bond strength, high tolerance to particle contamination and surface roughness, and cost savings. Furthermore, the glass substrates lower the parasitic capacitance and improve reliability. The major drawback is the trapped gas inside the cavities, which occurs during bonding. Earlier CMUT fabrication efforts using anodic bonding failed to demonstrate a vacuum-sealed cavity. In this study, we developed a fabrication scheme to overcome this issue and demonstrated vacuum-backed CMUTs using anodic bonding. This new approach also simplifies the overall fabrication process for CMUTs. We demonstrated a CMUT fabrication process with three lithography steps. A vibrating plate is formed by bonding the device layer of a silicon-on-insulator (SOI) wafer on top of submicron cavities defined on a borosilicate glass wafer. The cavities and the bottom electrodes are created on the borosilicate glass wafer with a single lithography step. The recessed bottom metal layer over the glass surface allows bonding the plate directly on glass posts and therefore helps reduce the parasitic capacitance and improve the breakdown reliability. A surface roughness of 0.8 nm is achieved in the cavity using wet chemical etching. A 200-nm PECVD silicon nitride layer deposited on the 2 µm device layer of the SOI wafer prior to bonding serves as the insulation layer to prevent shorting after pull-in. The trapped gas inside the cavities is evacuated after anodic bonding by reactive ion etching. The 120-nm cavities are then sealed with PECVD silicon nitride. We measured the atmospheric deflection of the plates after fabrication, which proves the vacuum inside the cavities. Impedance and hydrophone measurements were performed both in conventional (2.8 MHz) and collapse (7.2 MHz) modes. Bonding on posts with widths as small as 2 µm was successfully demonstrated using anodic bonding which is difficult to achieve with other wafer bonding methods.
Abstract 5700: Preparation and evaluation of glycosylated paclitaxel loaded in tastuzumab-immunoliposome (2012)

Abstract Targeted drug delivery is considered to enhance the therapeutic effects of anti-cancer agents because high amount could be administered with least side effects. However, water-insoluble hydrophobic chemical compounds such as paclitaxel are not suitable for efficient drug delivery. We conferred water-solubility of paclitaxel by coupling glucose at 7-OH to produce 7-alpha-glucosyloxyacetylpaclitaxel (7-GLG-PT). Although the 7-GLG-PT showed lower cytotoxicity than paclitaxel, encapsulation of 7-GLG-PT into liposomes was more efficient than that of paclitaxel. In our experiment, paclitaxel encapsulated liposomes was not detectable. Trastuzumab was then conjugated on the surface of 7-GLG-PT liposomes to prepare immunoliposome (GLG-PT-IL). The GLG-PT-IL exhibited cytotoxicity on SK-BR-3 cells overexpressing HER2. The IC50 values of paclitaxel, 7-GLG-PT, 7-GLG-PT liposome and GLG-PT-IL were 6, 126, 130 and 94 nM, respectively. From this evaluation, the concentration of each formula to suppress the cell growth completely was estimated around 30 to 300 nM. At these concentrations, the time required for each formula to suppress the growth at the half maximal level was evaluated. GLG-PT-IL showed the shortest time of 5 hours, which was one third of the others when compared with paclitaxel, 7-GLG-PT and 7-GLG-PT liposome. The specific targeting potential of the immunoliposome on SK-BR-3 cells was assessed. The accumulation on the cell surface was competitively inhibited by the excess amount of free tastuzumab. The endocytosis of the immunoliposomes was simultaneously confirmed by time-lapse imaging. Thus GLG-PT-IL has been successfully demonstrated to target the HER2-overexpressing cancer cells specifically suppressing their growth. Trastumab itself is considered to induce the antibody dependent cellular cytotoxicity, so that the endocytosis of HER2 may not be always necessary. However, HER2-mediated endocytosis was induced by the immunoliposomes while single trastuzumab did not show the endocytosis in SK-BR-3 cells. In this context together with the results demonstrated in this study, the 7-GLG-PT immunoliposome should be a promising candidate of highly efficient drug delivery system of cancer treatment targeting HER2. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5700. doi:1538-7445.AM2012-5700
An 802.11ba-Based Wake-Up Radio Receiver With Wi-Fi Transceiver Integration (2019)

This article presents an 802.11ba-based wake-up radio (WUR) receiver that is fully integrated within an 802.11a/b/g/n/ac Wi-Fi transceiver. Low-cost integration is achieved with the WUR only occupying 0.13 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> while not adding any additional overhead to the Wi-Fi platform. The WUR consumes 667 μW from 1.1-V Wi-Fi system supply. When measured from internal 0.6and 0.9-V supplies, the receiver consumes 495 μW. The receiver has a measured sensitivity of -92.6 dBm and can tolerate -40.5-dBm Wi-Fi adjacent channel blocker with 3-dB receiver de-sensitization. The WUR and Wi-Fi system co-operation is also demonstrated. The WUR receiver can operate when the Wi-Fi system is in sleep mode and can turn on Wi-Fi radio upon receiving 802.11ba-based wake-up packet.
A Modular Method for the High‐Yield Synthesis of Site‐Specific Protein–Polymer Therapeutics (2016)

Abstract A versatile method is described to engineer precisely defined protein/peptide–polymer therapeutics by a modular approach that consists of three steps: 1) fusion of a protein/peptide of interest with an elastin‐like polypeptide that enables facile purification and high yields; 2) installation of a clickable group at the C terminus of the recombinant protein/peptide with almost complete conversion by enzyme‐mediated ligation; and 3) attachment of a polymer by a click reaction with near‐quantitative conversion. We demonstrate that this modular approach is applicable to various protein/peptide drugs and used it to conjugate them to structurally diverse water‐soluble polymers that prolong the plasma circulation duration of these proteins. The protein/peptide–polymer conjugates exhibited significantly improved pharmacokinetics and therapeutic effects over the native protein/peptide upon administration to mice. The studies reported here provide a facile method for the synthesis of protein/peptide–polymer conjugates for therapeutic use and other applications.
Dehydration mechanism of optical clearing in tissue (2006)

Previous studies identified various mechanisms of light scattering reduction in tissue induced by chemical agents. Our results suggest that dehydration is an important mechanism of optical clearing in collagenous and cellular tissue. Photographic and optical coherence tomography images indicate that air-immersed skin and tendon specimens become similarly transparent to glycerol-immersed specimens. Transmission electron microscopy images reveal that dehydration causes individual scattering particles such as collagen fibrils and organelles to become more densely packed, but does not significantly alter size. A heuristic particle-interaction model predicts that the scattering particle volume fraction increase can contribute substantially to optical clearing in collagenous and cellular tissue.
Mechanisms of Inhibitory Effects of Polysubstituted Pyrimidines on Prostaglandin E2 Production (2019)

The pyrimidine heterocycle represents an elemental structural motif of numerous drugs. [...]
Real-time in situ monitoring of antireflection coatings for semiconductor laser amplifiers by ellipsometry (1992)

Very strict requirements need to be met for producing a high-quality single-layer antireflection coating on a traveling-wave laser amplifier facet. In order to obtain a facet reflectivity of 10/sup -4/ or less, the index of refraction and the layer thickness of single-layer coatings have to be controlled to better than 0.03 and 30 AA, respectively. An innovative approach to highly controlled antireflection layer deposition based on in situ real-time ellipsometry is presented. Index control within +or-0.01 and a facet reflectivity on the order of 10/sup -4/ are reproducibly obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Expression of Oncogenic Antigen 519 (OA-519) in Prostate Cancer Is a Potential Prognostic Indicator (1992)

Predicting the prognosis of patients with prostate cancer is a clinically important problem. Previous studies have indicated that the expression of haptoglobin-related protein epitopes in samples of breast cancer in early stages was associated with earlier relapses and higher risk for tumor recurrence. Oncogenic antigen 519 (OA-519) is the new marker designation for molecules expressing haptoglobin-related protein epitopes. The objective of this immunohistochemical study was to examine OA- 519 expression in prostate cancer samples and its relationship to the established prognostic indicators of tumor grade, tumor volume, and clinical stage. Forty-two consecutive tissue samples of prostate adenocarcinoma were examined using an affinitypurified anti-OA-519 antibody. Twenty specimens (48%) tested positive, whereas 22 (52%) tested negative. No staining was observed in normal or hyperplastic prostate tissue. Staining occurred in 6 of 9 (67%) grade III, 14 of 23 (61%) grade II, and in none of 10 (0%) grade I cases (I vs. II and/or III: Fisher exact test, P < 0.006). Twenty-three of the 42 samples were transurethral resection specimens with cancer; 11 (48%) of these tested positive. The mean percentage of tissue chips with tumor, a measure of tumor volume, was significantly higher in the positive group (57%) than in the negative group (15%) (P = 0.004). The proportion of positively stained cases increased with advancing clinical stage, with 25% of Stage A cases expressing OA-519, and 46%, 67%, and 64% of Stages B, C, and D, respectively, expressing OA-519. OA-519 expression correlates with higher tumor grades, larger tumors, and possibly with advanced stage, and thus, it is potentially of prognostic value in prostate cancer.
Expansive linguistic representations to predict interpretable odor mixture discriminability (2023)

Language is often thought as being poorly adapted to precisely describe or quantify smell and olfactory attributes. In this work, we show that semantic descriptors of odors can be implemented in a model to successfully predict odor mixture discriminability, an olfactory attribute. We achieved this by taking advantage of the structure-to-percept model we previously developed for monomolecular odorants, using chemical descriptors to predict pleasantness, intensity and 19 semantic descriptors such as "fish," "cold," "burnt," "garlic," "grass," and "sweet" for odor mixtures, followed by a metric learning to obtain odor mixture discriminability. Through this expansion of the representation of olfactory mixtures, our Semantic model outperforms state of the art methods by taking advantage of the intermediary semantic representations learned from human perception data to enhance and generalize the odor discriminability/similarity predictions. As 10 of the semantic descriptors were selected to predict discriminability/similarity, our approach meets the need of rapidly obtaining interpretable attributes of odor mixtures as illustrated by the difficulty of finding olfactory metamers. More fundamentally, it also shows that language can be used to establish a metric of discriminability in the everyday olfactory space.
Two user location strategies for personal communications services (1994)

The vision of nomadic personal communications is the ubiquitous availability of services to facilitate the exchange of information between nomadic end users independent of time, location, on access arrangements. To realize this, it is necessary to locate users who move from place to place. The strategies commonly proposed are two-level hierarchical strategies, which maintain a system of home and visited databases/spl mdash/home location register (HLR) and visitor location register (VLR)/spl mdash/to keep track of user locations. Two standards exist for carrying out two-level hierarchical strategies using HLRs and VLRs. The standard commonly used in North America is the Electronics Industry Association/Telecommunications Industry Association (EIA/TIA) Interim Standard 41 (IS-41), and in Europe the Global System for Mobile Communications (GSM). The authors introduce these two strategies for locating users and provide a tutorial on their usage. Different forms of mobility in the context of PCS and a reference model for a PCS architecture are discussed. The user location strategies specified in the IS-41 and GSM standards are described, and then, using a simple example, a simplified analysis of the database loads generated by each strategy is presented. Also briefly discussed are possible modifications to these protocols that are likely to result in significant benefits by reducing query and update rate to databases and/or reducing the signaling traffic.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Porous silicon as a substrate material for potentiometric biosensors (1996)

For the first time porous silicon has been investigated for the purpose of application as a substrate material for potentiometric biosensors operating in aqueous solutions. Porous silicon was prepared from differently doped silicon substrates by a standard anodic etching process. After oxidation, penicillinase, an enzyme sensitive to penicillin, was bound to the porous structure by physical adsorption. To characterize the electrochemical properties of the so build up penicillin biosensor, capacitance - voltage (C - V) measurements were performed on these field-effect structures.
Apparatus for irradiating a continuously flowing stream of fluid. [For neutron activation analysis] (1982)

An apparatus for irradiating a continuously flowing stream of fluid is disclosed. The apparatus consists of a housing having a spherical cavity and a spherical moderator containing a radiation source positioned within the spherical cavity. The spherical moderator is of lesser diameter than the spherical cavity so as to define a spherical annular volume around the moderator. The housing includes fluid intake and output conduits which open onto the spherical cavity at diametrically opposite positions. Fluid flows through the cavity around the spherical moderator and is uniformly irradiated due to the 4..pi.. radiation geometry. The irradiation source, for example a /sup 252/Cf neutron source, is removable from the spherical moderator through a radial bore which extends outwardly to an opening on the outside of the housing. The radiation source may be routinely removed without interrupting the flow of fluid or breaching the containment of the fluid.
The Demographics of Mail Search and their Application to Query Suggestion (2017)

Web mail search is an emerging topic, which has not been the object of as many studies as traditional Web search. In particular, little is known about the characteristics of mail searchers and of the queries they issue. We study here the characteristics of Web mail searchers, and explore how demographic signals such as location, age, gender, and inferred income, influence their search behavior. We try to understand for instance, whether women exhibit different mail search patterns than men, or whether senior people formulate more precise queries than younger people. We compare our results, obtained from the analysis of a Yahoo Web mail search query log, to similar work conducted in Web and Twitter search. In addition, we demonstrate the value of the user's personal query log, as well as of the global query log and of the demographic signals, in a key search task: dynamic query auto-completion. We discuss how going beyond users' personal query logs (their search history) significantly improves the quality of suggestions, in spite of the fact that a user's mailbox is perceived as being highly personal. In particular, we note the striking value of demographic features for queries relating to companies/organizations, thus verifying our assumption that query completion benefits from leveraging queries issued by ``people like me". We believe that demographics and other such global features can be leveraged in other mail applications, and hope that this work is a first step in this direction.
II:Ex vivo Viability Testing of Kidneys After Postmortem Warm Ischemia (2000)

Future approaches to expand the organ donor pool with marginal and nonheartbeating donors, will be dependent upon prospective organ evaluation. Restoration of metabolism by preservation at warmer temperatures could potentially provide the window for such evaluation. Using a small bovine model, kidneys were subjected to either < 15, < 30 or < 60 minutes of warm ischemia (WI) followed by cold ischemia (CI) in ViaSpan. After WI and CI, kidneys were transitioned to a warm temperature perfusion (30 degrees C to 32 degrees C) using exsanguinous metabolic support (EMS) technology. Restored renal metabolism and function was assessed by oxygen consumption, glucose consumption, urine production, glomerular filtration rate, and hemodynamic characteristics. The results of this study suggest that it is feasible to distinguish viable from nonviable organs ex vivo by assessing renal metabolism and function during warm preservation using EMS technology.
Scalable and thermally robust perpendicular magnetic tunnel junctions for STT-MRAM (2015)

Thermal budget, stack thickness, and dipolar offset field control are crucial for seamless integration of perpendicular magnetic junctions (pMTJ) into semiconductor integrated circuits to build scalable spin-transfer-torque magnetoresistive random access memory. This paper is concerned with materials and process tuning to deliver thermally robust (400 °C, 30 min) and thin (i.e., fewer layers and integration-friendly) pMTJ utilizing Co/Pt-based bottom pinned layers. Interlayer roughness control is identified as a key enabler to achieve high thermal budgets. The dipolar offset fields of the developed film stacks at scaled dimensions are evaluated by micromagnetic simulations. This paper shows a path towards achieving sub-15 nm-thick pMTJ with tunneling magnetoresistance ratio higher than 150% after 30 min of thermal excursion at 400 °C.
Enrichment of Collagen Fragments Using Dimeric Collagen Hybridizing Peptide for Urinary Collagenomics (2020)

Collagen remodeling in normal and pathologic conditions releases numerous collagen fragments into biological fluids. Although a few collagen fragments have been tested as biomarkers for disease indication, most occur at trace levels, making them nearly impossible to detect even with modern analytical tools. Here we report a new way to enrich collagen fragments that allows complete peptidomic analysis of collagen fragments in urine. Enrichment is made possible by dimeric collagen hybridizing peptides (CHPs) that bind collagen fragments originating from the triple helical regions of all collagen types with minimal sequence bias. LC-MS/MS analysis of enriched mouse urine revealed an average of 383 collagenous peptide fragments per sample (compared to 34 for unenriched sample), which could be mapped to all types of mouse collagens in the SwissProt database including FACITs and MACITs. Hierarchical clustering of a selected panel of the detected fragments separated osteopenic mice from healthy mice. The results demonstrate dimeric CHP's ability to enrich collagen fragments from biological fluid and its potential to aid peptidomics-based disease detection and biomarker discovery.
Laboratory intercomparison for the evaluation of the delamination propensity of glass containers for pharmaceutical use (2020)

Abstract This paper is the result of two round robin activities run by the Technical Committee TC12, Pharma Packaging, of the International Commission on Glass (ICG). It deals with the phenomenon of delamination, that is, the formation of lamellae or flakes in drug products due to specific and localized corrosion of glass vials, and it follows a first paper PDA J Pharm Sci Technol . 2018 , 72 , 553–565where a testing protocol for the evaluation of the delamination propensity was proposed. The results showed that the protocol gives information on the quality of vials with respect to the propensity to corrosion, but no direct correlation with delamination could be demonstrated, as no lamellae formation was observed. In response, further testing was carried out on five sets of vials with expected low delamination propensity, compared to a set of vials with high expected delamination propensity using both the proposed protocol and a more aggressive protocol. The objective was to observe lamellae at least in the high propensity vials to show a correlation to initial test protocols. The results show that there is a very good consistency between the results of the two testing protocols and therefore, with a good level of reliability, the degree of glass surface corrosion can be estimated by the testing protocol proposed by the Technical Committee. In some cases, the glass surface corrosion results may indicate an increased risk of delamination (depending on the individual interaction between the pharmaceutical solution and the inner vial surface).
Small‐Conductance Calcium‐Activated Potassium Channels (1999)

SK channels play a fundamental role in all excitable cells. SK channels are potassium selective and are activated by an increase in the level of intracellular calcium, such as occurs during an action potential. Their activation causes membrane hyperpolarization, which inhibits cell firing and limits the firing frequency of repetitive action potentials. The intracellular calcium increase evoked by action potential firing decays slowly, allowing SK channel activation to generate a long-lasting hyperpolarization termed the slow afterhyperpolarization (sAHP). This spike-frequency adaptation protects the cell from the deleterious effects of continuous tetanic activity and is essential for normal neurotransmission. Slow AHPs can be classified into two groups, based on sensitivity to the bee venom toxin apamin. In general, apamin-sensitive sAHPs activate rapidly following a single action potential and decay with a time constant of approximately 150 ms. In contrast, apamin-insensitive sAHPs rise slowly and decay with a time constant of approximately 1.5 s. The basis for this kinetic difference is not yet understood. Apamin-sensitive and apamin-insensitive SK channels have recently been cloned. This chapter will compare with different classes of sAHPs, discuss the cloned SK channels and how they are gated by calcium ions, describe the molecular basis for their different pharmacologies, and review the possible role of SK channels in several pathological conditions.
Binary encoding of gray scale nonlinear joint transform correlators (1991)

A nonlinear joint transform correlator is described where the joint power spectrum, transformed by various degrees of nonlinearity, is represented in a binary format using a multiple level threshold function.
Towards Sub-Wavelength Plasmonic Laser Devices (2009)

We show that a hybrid of semiconductor nanowire and metallic surface modes produces an efficient laser device with λ2/100 mode area and discuss the broader impact of plasmon-based light sources and integrated optical components.