gebhart/patrepeval huggingface dataset:
Exotic Hadron in Pole-Dominated QCD Sum Rules (2007)

We study pentaquark + (I = 0, J = 1/2) in the QCD sum rules emphasizing that we cannot extract any properties of the pentaquark outside of the Borel window. To find the appropriate Borel window, we prepare a favorable set up of the correlators and carry out the operator product expansion up to dimension 15 within factorization hypothesis. Our procedures reduce the unwanted high energy contaminations and enhance the low energy correlation. In the Borel window, independent analyses for the chiral-even and odd sum rules give the consistent values of the + mass, 1.68 0.22 GeV, and the residue. The parity is found to be positive.
Real-time system for respiratory-cardiac gating in positron tomography (1998)

A Macintosh-based signal processing system has been developed to support simultaneous respiratory and cardiac gating on the ECAT EXACT HR PET scanner. Using the Lab-View real-time software environment, the system reads analog inputs from a pneumatic respiratory bellows and an ECG monitor to compute an appropriate histogram memory location for the PET data. Respiratory state is determined by the bellows signal amplitude; cardiac state is based on the time since the last R-wave. These two states are used in a 2D lookup table to determine a combined respiratory-cardiac state. A 4-bit address encoding the selected histogram is directed from the system to the ECAT scanner, which dynamically switches the destination of tomograph events as respiratory-cardiac state changes. To test the switching efficiency of the combined Macintosh/ECAT system, a rotating emission phantom was built. Acquisitions with 25 msec states while the phantom was rotating at 240 rpm demonstrate the system could effectively stop motion at this rate, with approximately 5 msec switching time between states.
Global Optimality in Low-Rank Matrix Optimization (2018)

This paper considers the minimization of a general objective function f(X) over the set of rectangular n × m matrices that have rank at most r. To reduce the computational burden, we factorize the variable X into a product of two smaller matrices and optimize over these two matrices instead of X. Despite the resulting nonconvexity, recent studies in matrix completion and sensing have shown that the factored problem has no spurious local minima and obeys the so-called strict saddle property (the function has a directional negative curvature at all critical points but local minima). We analyze the global geometry for a general and yet well-conditioned objective function f(X) whose restricted strong convexity and restricted strong smoothness constants are comparable. In particular, we show that the reformulated objective function has no spurious local minima and obeys the strict saddle property. These geometric properties imply that a number of iterative optimization algorithms (such as gradient descent) can provably solve the factored problem with global convergence.
Evidence of frequent recombination among human adenoviruses (2008)

Genome stability is a prerequisite for the production and use of adenoviruses for therapy of genetic diseases and cancer. To test the premise that the adenoviral genome is stable, the phylogenetic relationships of 16 adenovirus C (AdC) field isolates were studied in four genome regions: hexon, fiber, polymerase and E1A. The phylogenetic relationships in the fiber gene concurred with those in the hexon region. In contrast, the non-structural regions had marks of frequent recombination, to the point that an isolate of one serotype could contain non-structural proteins that were identical to the genes from a different serotype. Our results suggest that recombination among circulating adenoviruses is very frequent and plays an important role in shaping the phylogenetic relationships of adenovirus genomes. Analysis of the available complete genome sequences of AdB, AdC and AdD species showed that recombination shuffles genome fragments within a species, but not between species. One of the AdC field isolates possessed the fiber gene of AdC type 6, but a hexon gene that was distinct from all AdC serotypes. This strain could not be typed unambiguously in a neutralization test and might represent a novel serotype of AdC. Comparison of the right end (nt 18838-33452) of this isolate with that of the ATCC Ad6 strain showed clear evidence of multiple recombination events.
Temperature-dependent emission intensity and energy shift in InGaN/GaN multiple-quantum-well light-emitting diodes (2003)

Temperature-dependent electroluminescence (EL) of InGaN/GaN multiple-quantum-well light-emitting diodes (LEDs) has been investigated to illustrate the role of localization effects in carrier capture and recombination. The devices have identical structure but with varying indium content in the active region. A large redshift of the emission peak with decreasing temperature is observed in the UV and blue LEDs over the temperature range of 77–200 K, accompanying a pronounced decrease of EL intensity. This redshift reflects carrier relaxation into lower energy localized states and the change in carrier recombination dynamics at low temperatures. In contrast, the peak energy of the green LEDs exhibits a smaller temperature-induced shift, and the emission intensity increases monotonically with decreasing temperature down to 5 K. Based on a rate equation analysis, we find that the densities of the localized states in the green LEDs are more than two orders of magnitude higher than that in the UV LED.
Learning Optimal Solutions for Extremely Fast AC Optimal Power Flow (2020)

We develop, in this paper, a machine learning approach to optimize the real-time operation of electric power grids. In particular, we learn feasible solutions to the AC optimal power flow (OPF) problem with negligible optimality gaps. The AC OPF problem aims at identifying optimal operational conditions of the power grids that minimize power losses and/or generation costs. Due to the computational challenges with solving this nonconvex problem, many efforts have focused on linearizing or approximating the problem in order to solve the AC OPF on faster timescales. However, many of these approximations can be fairly poor representations of the actual system state and still require solving an optimization problem, which can be time consuming for large networks. In this work, we learn a mapping between the system loading and optimal generation values, enabling us to find near-optimal and feasible AC OPF solutions. This allows us to bypass solving the traditionally nonconvex AC OPF problem, resulting in a significant decrease in computational burden for grid operators.
Directed Evolution of Pyruvate Decarboxylase-Negative <i>Saccharomyces cerevisiae</i> , Yielding a C <sub>2</sub> -Independent, Glucose-Tolerant, and Pyruvate-Hyperproducing Yeast (2004)

The absence of alcoholic fermentation makes pyruvate decarboxylase-negative (Pdc(-)) strains of Saccharomyces cerevisiae an interesting platform for further metabolic engineering of central metabolism. However, Pdc(-) S. cerevisiae strains have two growth defects: (i) growth on synthetic medium in glucose-limited chemostat cultures requires the addition of small amounts of ethanol or acetate and (ii) even in the presence of a C(2) compound, these strains cannot grow in batch cultures on synthetic medium with glucose. We used two subsequent phenotypic selection strategies to obtain a Pdc(-) strain without these growth defects. An acetate-independent Pdc(-) mutant was obtained via (otherwise) glucose-limited chemostat cultivation by progressively lowering the acetate content in the feed. Transcriptome analysis did not reveal the mechanisms behind the C(2) independence. Further selection for glucose tolerance in shake flasks resulted in a Pdc(-) S. cerevisiae mutant (TAM) that could grow in batch cultures ( micro (max) = 0.20 h(-1)) on synthetic medium, with glucose as the sole carbon source. Although the exact molecular mechanisms underlying the glucose-tolerant phenotype were not resolved, transcriptome analysis of the TAM strain revealed increased transcript levels of many glucose-repressible genes relative to the isogenic wild type in nitrogen-limited chemostat cultures with excess glucose. In pH-controlled aerobic batch cultures, the TAM strain produced large amounts of pyruvate. By repeated glucose feeding, a pyruvate concentration of 135 g liter(-1) was obtained, with a specific pyruvate production rate of 6 to 7 mmol g of biomass(-1) h(-1) during the exponential-growth phase and an overall yield of 0.54 g of pyruvate g of glucose(-1).
Biofilm formation by the Enterobacteriaceae: a comparison between Salmonella enteritidis, Escherichia coli and a nitrogen‐fixing strain of Klebsiella pneumoniae (1996)

A simple laboratory reactor, which simulates biofilm formation in pipes, was used to compare biofilm formation by three members of the Enterobacteriaceae, namely, an environmental, nitrogen-fixing strain of Klebsiella pneumoniae, a pathogen, Salmonella enteritidis, and a faecal indicator, Escherichia coli. All three attached to CVCP pipe surfaces in the reactor and formed substantial biofilm populations of over a million bacteria cm-2 within 24 h. These populations increased by approximately 10-fold over the next 48 h. Estimates of the numbers of metabolically active cells and the ratios of viable to direct counts showed that Kl. pneumoniae formed the densest and most metabolically active biofilms, followed by Salm. enteritidis and E. coli, respectively. Nitrogen fixation and polysaccharide production (EPS) by Kl. pneumoniae occurred only in mature biofilms and were of no selective advantage in the initiation of biofilms. Despite producing more EPS the rate of attachment of Salm. enteritidis was lower than for Kl. pneumoniae.
TYRP2-mediated resistance to cis-diamminedichloroplatinum (II) in human melanoma cells is independent of tyrosinase and TYRP1 expression and melanin content (2000)

Tyrosinase-related protein-2 (TYRP2) is a melanocyte-specific enzyme that catalyses the non-decarboxylative tautomerization of L-dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA) in the melanin biosynthetic pathway. We have recently demonstrated that the constitutive expression of TYRP2 in human melanoma cells positively correlates with cis-diamminedichloroplatinum (II) (CDDP) resistance, and that the ectopic expression of TYRP2 in CDDP-sensitive cells rendered them more resistant to CDDP treatment. Here, we demonstrate that this correlation between constitutive TYRP2 expression and CDDP resistance applies to a panel of distinct human melanoma cell lines obtained from patients with melanoma at various stages of disease progression. We further show that CDDP resistance correlates only with TYRP2 expression and is associated neither with tyrosinase and TYRP1 expression, nor with cellular melanin content. Together, these results further support the notion that TYRP2 is a novel mediator of CDDP resistance in melanoma cells and suggest that this function of TYRP2 is independent of cellular melanin content and of the other regulatory enzymes of the melanogenic pathway.
Early Diagnosis of Acute Myocardial Infarction by CK-MB Mass Measurements (1992)

We have studied the changes in creatine kinase (CK) and creatine kinase MB (CK-MB) activity and concentration for the diagnosis of acute myocardial infarction in 73 patients admitted to the coronary care unit with cardiac symptoms of 12 h duration or less. Serial blood samples were obtained for an 8 h period following admission and CK, CK-MB activity and concentration measured. We compared the performance of single values at optimized diagnostic cut-offs and incremental change (log slope) for all three measurements. CK slope combined with CK-MB concentration measurements allowed accurate diagnosis at 4 h from admission. CK-MB concentration determination 8 h from admission (12-16 h from the onset of chest pain) was the most efficient single measurement. Rapid diagnostic categorization and possible selection of patients for thrombolysis in patients with an uncertain admission diagnosis is possible by these techniques.
Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura (2005)

We assessed safety and efficacy of rituximab in a prospective study of 36 patients, age 2.6 to 18.3 years, with severe chronic immune thrombocytopenic purpura (ITP). The primary outcome of sustained platelets above 50 x 10(9)/L (50,000/mm3) during 4 consecutive weeks, starting in weeks 9 to 12, was achieved by 11 of 36 patients (31%, confidence interval [CI], 16% to 48%). Median response time was 1 week (range, 1 to 7 weeks). Attainment of the primary outcome was not associated with age, prior pharmacologic responses, prior splenectomy, ITP duration, screening platelet count, refractoriness, or IgM reduction. First-dose, infusion-related toxicity was common (47%) despite premedication. Significant drug-related toxicities included third-dose hypotension (n = 1) and serum sickness (n = 2). Peripheral B cells were depleted in all subjects. IgM decreased 3.4% per week, but IgG did not significantly decrease. Rituximab was well tolerated, with manageable infusion-related side effects, but 6% of subjects developed serum sickness. Rituximab is beneficial for some pediatric patients with severe, chronic ITP.
WearID: Wearable-Assisted Low-Effort Authentication to Voice Assistants using Cross-Domain Speech Similarity (2020)

Due to the open nature of voice input, voice assistant (VA) systems (e.g., Google Home and Amazon Alexa) are under a high risk of sensitive information leakage (e.g., personal schedules and shopping accounts). Though the existing VA systems may employ voice features to identify users, they are still vulnerable to various acoustic attacks (e.g., impersonation, replay and hidden command attacks). In this work, we focus on the security issues of the emerging VA systems and aim to protect the users' highly sensitive information from these attacks. Towards this end, we propose a system, WearID, which uses an off-the-shelf wearable device (e.g., a smartwatch or bracelet) as a secure token to verify the user's voice commands to the VA system. In particular, WearID exploits the readily available motion sensors from most wearables to describe the command sound in vibration domain and check the received command sound across two domains (i.e., wearable's motion sensor vs. VA device's microphone) to ensure the sound is from the legitimate user.
Structure development in multistage stretching of PTFE films (2010)

Abstract The structure of expanded poly(tetrafluoroethylene) (ePTFE) films that were produced by uniaxial or biaxial stretching of a calendared sheet were studied by wide angle X‐ray diffraction (WAXD), small angle X‐ray scattering, differential scanning calorimetry (DSC), and scanning electron microscopy. The molecular orientation of the stretched films was analyzed by WAXD flat films and pole figures. Biaxial orientation factors were computed to interpret the level of orientation quantitatively. DSC scans showed that oriented samples exhibited two melting peaks, one at the commonly observed temperature in the range 340–345 °C and one around 380 °C. The possible causes of this high‐temperature melting peak and its relation to previously described processes is discussed. The microporous nature of the ePTFE films is also briefly discussed. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2010
Proton conductivity in ampullae of Lorenzini jelly (2016)

In 1678, Stefano Lorenzini first described a network of organs of unknown function in the torpedo ray-the ampullae of Lorenzini (AoL). An individual ampulla consists of a pore on the skin that is open to the environment, a canal containing a jelly and leading to an alveolus with a series of electrosensing cells. The role of the AoL remained a mystery for almost 300 years until research demonstrated that skates, sharks, and rays detect very weak electric fields produced by a potential prey. The AoL jelly likely contributes to this electrosensing function, yet the exact details of this contribution remain unclear. We measure the proton conductivity of the AoL jelly extracted from skates and sharks. The room-temperature proton conductivity of the AoL jelly is very high at 2 ± 1 mS/cm. This conductivity is only 40-fold lower than the current state-of-the-art proton-conducting polymer Nafion, and it is the highest reported for a biological material so far. We suggest that keratan sulfate, identified previously in the AoL jelly and confirmed here, may contribute to the high proton conductivity of the AoL jelly with its sulfate groups-acid groups and proton donors. We hope that the observed high proton conductivity of the AoL jelly may contribute to future studies of the AoL function.
Inhibition of serotonergic medullary raphe obscurus neurons suppresses genioglossus and diaphragm activities in anesthetized but not conscious rats (2006)

Although exogenous serotonin at the hypoglossal motor nucleus (HMN) activates the genioglossus muscle, endogenous serotonin plays a minimal role in modulating genioglossus activity in awake and sleeping rats (Sood S, Morrison JL, Liu H, and Horner RL. Am J Respir Crit Care Med 172: 1338-1347, 2005). This result therefore implies that medullary raphe neurons also play a minimal role in the normal physiological control of the HMN, but this has not yet been established because raphe neurons release other excitatory neurotransmitters onto respiratory motoneurons in addition to serotonin. This study tests the hypothesis that inhibition of medullary raphe serotonergic neurons with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) suppresses genioglossus and diaphragm activities in awake and sleeping rats. Ten rats were implanted with electrodes to record sleep-wake states and genioglossus and diaphragm activities. Microdialysis probes were also implanted into the nucleus raphe obscurus (NRO). Experiments in 10 anesthetized and vagotomized rats were also performed using the same methodology. In anesthetized rats, microdialysis perfusion of 0.1 mM 8-OH-DPAT into the NRO decreased genioglossus activity by 60.7+/-9.0% and diaphragm activity by 13.3+/-3.4%. Diaphragm responses to 7.5% CO2 were also significantly reduced by 8-OH-DPAT. However, despite the robust effects observed in anesthetized and vagotomized rats, there was no effect of 0.1 mM 8-OH-DPAT on genioglossus or diaphragm activities in conscious rats awake or asleep. The results support the concept that endogenously active serotonergic medullary raphe neurons play a minimal role in modulating respiratory motor activity across natural sleep-wake states in freely behaving rodents. This result has implications for pharmacological strategies aiming to manipulate raphe neurons and endogenous serotonin in obstructive sleep apnea.
LINE‐1 retrotransposons in healthy and diseased human brain (2017)

Long interspersed element-1 (LINE-1 or L1) is a transposable element with the ability to self-mobilize throughout the human genome. The L1 elements found in the human brain is hypothesized to date back 56 million years ago and has survived evolution, currently accounting for 17% of the human genome. L1 retrotransposition has been theorized to contribute to somatic mosaicism. This review focuses on the presence of L1 in the healthy and diseased human brain, such as in autism spectrum disorders. Throughout this exploration, we will discuss the impact L1 has on neurological disorders that can occur throughout the human lifetime. With this, we hope to better understand the complex role of L1 in the human brain development and its implications to human cognition. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 434-455, 2018.
Dupilumab for Systemic Allergy Syndrome With Dermatitis (2019)

Allergic contact dermatitis (ACD) has been traditionally identified as TH1-mediated delayed-type hypersensitivity reactions. There is currently no Food and Drug Administration-approved systemic therapy indicated for ACD. Among patients with ACD, there is a subgroup that experience not only concomitant atopic dermatitis and ACD but also systemic allergic dermatitis driven by allergens encountered through dietary consumption. Basic science and clinical studies have supported the notion that ACD involves a complex interaction between both TH1 and TH2 axes of the secondary immune system on an allergen-by-allergen basis. Herein, we report the patients with systemic allergy syndrome with dermatitis to either Balsam of Peru or nickel who achieved remarkable improvement and regained their quality of life without continuing adherence to strict diets. Our study suggests that dupilumab may be an efficacious solution for a particular subgroup of patients with recalcitrant ACD when first- and second-line therapies have failed.
Outdoor polymeric insulators long-term exposed to HVDC (1997)

Field experience from outdoor polymeric insulators exposed to HVDC under natural contamination conditions is presented. This paper summarizes the peak leakage current statistics, the hydrophobicity and the surface material conditions studied by electron spectroscopy for chemical analysis (ESCA) and attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy. The results show a strong interrelation between the surface conditions and the performance with respect to leakage currents. Moreover, the results show that the surface conditions and the performance of the insulators exposed to HVDC are rather similar to those of the insulators exposed to HVAC.
<scp>l</scp>‐Ornithine‐<scp>l</scp>‐aspartate in the management of hepatic encephalopathy: A meta‐analysis (2008)

LOLA benefited patients with overt hepatic encephalopathy (I or II), whereas these data do not support the use of LOLA for patients with subclinical hepatic encephalopathy.
Photoinduced oxidation of a water-soluble manganese(III) porphyrin (1986)

The photoinduced oxidation of tetra(N-methyl-4-pyridyl)porphyrinmanganese(III) has been achieved in homogeneous solution. The manganese porphyrin was used as an electron donor in a three-component system with tris-(2,2'-bipyridine)ruthenium(II) as the photosensitizer and chloropentaamminecobalt(III) as the electron acceptor. The photooxidized manganese porphyrin is unstable in aqueous solution, reverting to the starting manganese(III) porphyrin. The oxidation of manganese(III) porphyrin and the subsequent reduction of the oxidized porphyrin can be cycled repeatedly.
RBE Model-Based Biological Dose Optimization for Proton Radiobiology Studies (2018)

We have successfully developed an easy-to-implement method to perform the biological dose optimization procedure by invoking the McNamara RBE model in the iteration process using the Python programming language. According to the RBE model predictions, we conclude that the increased target LET <i><sub>d</sub></i> enhances the RBE. The accuracy of the RBE model predictions needs to be validated in radiobiological experiments.
Implications of shorted turn faults in bar wound PM machines (2004)

The paper discusses the effect of single turn short-circuits in the windings of fault tolerant permanent magnet machines. It is shown that previously recognised methods for dealing with shorted turns do not work for larger bar-wound machines, and a new method for protecting the windings against single turn faults is therefore proposed. The new method depends on rapid detection of the fault and injection of a current (of appropriate magnitude and phase) into the faulted winding. The paper gives a theoretical analysis supported by finite element simulations of the fault conditions and illustrates these with a case study taken from the aerospace industry.