gebhart/patrepeval huggingface dataset:
Phosphonate‐modified Gd‐DTPA complexes. III: The detection of myocardial infarction by MRI (1993)

The potential of a phosphonate-modified-Gd-DTPA for MR image enhancement of myocardial infarction has been demonstrated in imaging experiments on rats. The agent, 1-hydroxy-3-aminopropane-1,1-diphosphonate-modified-Gd-DTPA (Gd-DTPA-HPDP) accumulates in two models of myocardial infarction, (i.e., drug-induced diffusely infarcted whole hearts and in focal acute myocardial infarction from a left coronary artery ligation). The time course of the accumulation of the agent in the focal model of infarction and subsequent washout has also been followed in vitro. Results of this kinetics demonstrate that the agent first perfuses all normal fluid spaces and then slowly diffuses into the occluded zone where it is retained for a prolonged period, in sufficient quantities to be useful as an MRI contrast agent. Wash-out of the agent from normal myocardium is fast and complete with MR signal returning to background in minutes. The specificity of Gd-DTPA-HPDP for soft-tissue calcification and its retention within the infarcts permitted imaging at 1 to 2 h postinjection, (after unbound material has cleared the normal tissues). Infarcted tissue appeared as regions of increased signal intensity in T1-weighted images (> 200% enhancement), and correlated with histopathology. Unmodified Gd-DTPA was not retained under identical conditions. Gd-DTPA-HPDP permits a more accurate infarct delineation than is possible with the unmodified agent.
Constructing a Log Collecting System using Splunk and its Application for Service Support (2016)

The operation of the education and research system, which includes network, server and client services, produces a variety of log output. The effective analysis of these logs makes it is possible to ascertain user trends, and often points to issues that require troubleshooting. However, due to the difference in the type and diversity of format of the log, it takes a considerable amount of effort to organize them in a cross-sectional manner in order to obtain useful information. To resolve this issue, we have constructed a log collecting system by using Splunk to centrally aggregate logs. Most logs are automatically stored on the Splunk database from each system. As a result, the administrator and service support staff can view these logs via a simple interface, and can check the usage of the users across multiple systems in near real time. In this paper, we introduce how to approach and construct a system in order to change the logs of the various systems to be able to obtain valuable information. We also show how you can utilize aggregated log for service support and security. Particularly based on the user ID and IP addresses, it is possible to gain a bird's-eye view of logs for analysis, making it a valid tool for understanding user behavior.
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain (2018)

Despite the initial promise of immunotherapy for CNS disease, multiple recent clinical trials have failed. This may be due in part to characteristically low penetration of antibodies to cerebrospinal fluid (CSF) and brain parenchyma, resulting in poor target engagement. We here utilized transcranial macroscopic imaging to noninvasively evaluate in vivo delivery pathways of CSF fluorescent tracers. Tracers in CSF proved to be distributed through a brain-wide network of periarterial spaces, previously denoted as the glymphatic system. CSF tracer entry was enhanced approximately 3-fold by increasing plasma osmolality without disruption of the blood-brain barrier. Further, plasma hyperosmolality overrode the inhibition of glymphatic transport that characterizes the awake state and reversed glymphatic suppression in a mouse model of Alzheimer's disease. Plasma hyperosmolality enhanced the delivery of an amyloid-β (Aβ) antibody, obtaining a 5-fold increase in antibody binding to Aβ plaques. Thus, manipulation of glymphatic activity may represent a novel strategy for improving penetration of therapeutic antibodies to the CNS.
Reliability constrained routing in QoS networks (2005)

The issue of handling network failures is becoming increasingly important. In this paper, we address the problem of constrained routing by treating reliability as one of the QoS requirements. The problem is to create a feasible path from a given node to the destination such that the bandwidth and reliability requirements of the path are satisfied and the cost of the path is minimized (Reliability Constrained Least Cost Routing Problem). To solve the problem, we propose an approach which employs a novel concept, called partial protection, wherein backup paths are created for a selected set of domains in the network so as to meet the reliability constraints. The Partial Protection Approach (PPA) has two steps: Primary Path Creation and Backup Path Creation if necessary. To implement PPA, we propose three scalable two-pass resource reservation schemes, viz., Conservative, Optimistic, and Hybrid schemes. These schemes differ depending on whether the backup paths are created during the forward pass, reverse pass, or both. We evaluate the performance of the proposed schemes for dynamic multicast groups with different bandwidth and reliability requirements using average call acceptance rate and average tree cost as performance metrics. Our studies show that group dynamics and reliability requirements have significant impact on the performance of the schemes.
CHAPTER 1. Polymerization of Phosphorus-Containing (Meth)acrylate Monomers (2014)

International audience
Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide (2016)

The cyclodepsipeptide doliculide is a marine natural product with strong actin-polymerizing and anticancer activities. Evidence for doliculide acting as a potent and subtype-selective antagonist of prostanoid E receptor 3 (EP3) is presented. Computational target prediction suggested that this membrane receptor is a likely macromolecular target and enabled immediate in vitro validation. This proof-of-concept study demonstrates the in silico deorphanization of phenotypic screening hits as a viable concept for future natural-product-inspired chemical biology and drug discovery efforts.
N-Glycans of F Protein Differentially Affect Fusion Activity of Human Respiratory Syncytial Virus (2001)

The human respiratory syncytial virus (Long strain) fusion protein contains six potential N-glycosylation sites: N27, N70, N116, N120, N126, and N500. Site-directed mutagenesis of these positions revealed that the mature fusion protein contains three N-linked oligosaccharides, attached to N27, N70, and N500. By introducing these mutations into the F gene in different combinations, four more mutants were generated. All mutants, including a triple mutant devoid of any N-linked oligosaccharide, were efficiently transported to the plasma membrane, as determined by flow cytometry and cell surface biotinylation. None of the glycosylation mutations interfered with proteolytic activation of the fusion protein. Despite similar levels of cell surface expression, the glycosylation mutants affected fusion activity in different ways. While the N27Q mutation did not have an effect on syncytium formation, loss of the N70-glycan caused a fusion activity increase of 40%. Elimination of both N-glycans (N27/70Q mutant) reduced the fusion activity by about 50%. A more pronounced reduction of the fusion activity of about 90% was observed with the mutants N500Q, N27/500Q, and N70/500Q. Almost no fusion activity was detected with the triple mutant N27/70/500Q. These data indicate that N-glycosylation of the F2 subunit at N27 and N70 is of minor importance for the fusion activity of the F protein. The single N-glycan of the F1 subunit attached to N500, however, is required for efficient syncytium formation.
Characterization of the IgE Receptor Isolated from Human Basophils (1979)

The IgE receptor of human basophils was purified by using simple and repetitive affinity chromatography on human IgE-Sepharose. Basophils were partially purified from peripheral blood of patients with chronic myelogenous or basophilic leukemia. Cells were labeled with 125I by using the lactoperoxidase method and were solubilized with nonionic detergent. Elution of IgE-Sepharose with 0.5 N acetic acid, 1% NP-40 allowed recovery of active IgE receptor. Analysis of human IgE receptor by SDS polyacrylamide gel electrophoresis with 10% gels demonstrated one major radioactive peak with an apparent m.w. of 58,000 to 68,000, somewhat larger than rat IgE receptor. The purified human IgE receptor was active since approximately 10 to 42% of labeled receptor could specifically rebind to insolubilized human IgE. Rebinding was blocked by nanomolar concentrations of soluble human IgE or rat IgE but not by human or rat IgG, heat-inactivated human IgE, or heat-aggregated human IgG; thus it appears that rat IgE receptor. The relative abilities of active rat IgE and active human IgE to inhibit human IgE receptor rebinding could not be precisely determined because of the limitations in assessing the proportion of human IgE that retains receptor-binding activity.
BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries (2015)

Blocking BET bromodomains mitigates neointima formation, suggesting an epigenetic approach for effective prevention of intimal hyperplasia and associated vascular diseases.
Applying STOPP Guidelines in Primary Care Through Electronic Medical Record Decision Support: Randomized Control Trial Highlighting the Importance of Data Quality (2017)

Clinicaltrials.gov NCT02130895; https://clinicaltrials.gov/ct2/show/NCT02130895 (Archived by WebCite at http://www.webcitation.org/6qyFigSYT).
Plant compartment and genetic variation drive microbiome composition in switchgrass roots (2018)

Switchgrass (Panicum virgatum) is a promising biofuel crop native to the United States with genotypes that are adapted to a wide range of distinct ecosystems. Various plants have been shown to undergo symbioses with plant growth-promoting bacteria and fungi, however, plant-associated microbial communities of switchgrass have not been extensively studied to date. We present 16S ribosomal RNA gene and internal transcribed spacer (ITS) data of rhizosphere and root endosphere compartments of four switchgrass genotypes to test the hypothesis that host selection of its root microbiota prevails after transfer to non-native soil. We show that differences in bacterial, archaeal and fungal community composition and diversity are strongly driven by plant compartment and switchgrass genotypes and ecotypes. Plant-associated microbiota show an enrichment in Alphaproteobacteria and Actinobacteria as well as Sordariales and Pleosporales compared with the surrounding soil. Root associated compartments display low-complexity communities dominated and enriched in Actinobacteria, in particular Streptomyces, in the lowland genotypes, and in Alphaproteobacteria, specifically Sphingobium, in the upland genotypes. Our comprehensive root analysis serves as a snapshot of host-specific bacterial and fungal associations of switchgrass in the field and confirms that host-selected microbiomes persist after transfer to non-native soil.
Optical detection of organic vapors using cholesteric liquid crystals (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Chin-Kai Chang, Hui-Lung Kuo, Kea-Tiong Tang, Shih-Wen Chiu; Optical detection of organic vapors using cholesteric liquid crystals. Appl. Phys. Lett. 15 August 2011; 99 (7): 073504. https://doi.org/10.1063/1.3627162 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Which households eligible for public housing do not apply and why? (2005)

Among low-income households in private rental, who are potentially eligible for public housing, those who value security of tenure tend to apply for public housing while those who value choice tend to remain in private rental. Additionally, poor awareness of public housing and long wait times are deterrents to households applying for public housing.
Activation of Dimethyl Zirconocene by Methylaluminoxane (MAO)Size Estimate for Me-MAO<sup>-</sup> Anions by Pulsed Field-Gradient NMR (2002)

In a study of the reaction system MAO/(C5H5)2ZrMe2, the size of the ion pair [(C5H5)2Zr(mu-Me)2AlMe2]+ [Me-MAO]- was determined by pulsed field-gradient NMR of its cationic moiety. A mean effective hydrodynamic radius of 12.2-12.5 A, determined from diffusion rates in benzene solution at different zirconocene and MAO concentrations, indicates that the ion pair remains associated even at the lowest concentrations studied. At elevated concentrations, aggregation to ion quadruples or higher aggregates is indicated by an apparent size increase and by shifts of the C5H5 and Me 1H NMR signals. The equilibrium constant for the reaction [(C5H5)2ZrMe+...Me-MAO-] + 1/2Al2Me6 right harpoon over left harpoon [(C5H5)2Zr(mu-Me)2AlMe2]+ [Me-MAO]- changes at different Al/Zr ratios; this indicates that MAO contains various species that produce Me-MAO- anions with different Lewis basicities. The volume of the Me-MAO- anion suggests that it contains 150-200 Al atoms.
Fast Image Blending and Deghosting for Panoramic Video (2013)

The technology of panoramic image construction is widely used in many conditions. As the increasingly demand of monitoring system application, the attribute of real-time is more important during the panoramic construction. This paper describes a method of fast building panoramic video and output frames in real-time. SURF algorithm is employed to extract features and a new method is developed to eliminate matching mistakes in this work. As traditional transform method use only one homography matrix, the stitch error in detail is obvious. In this paper the modified dual-homography is proposed to improve the stitch performance. Ghosting effect is a universal problem in image stitching and difficult to avoid. This topic use image subtraction and smooth transition blending method to avoid ghost. Since this topic skips the seam finding process, so the time consumption is low and the method can achieve real-time requirement.
Rat Liver Arginase Suppresses Mixed Lymphocyte Reaction (1990)

An inhibitory factor to mixed lymphocyte reaction (MLR) was purified from the supernatant of rat liver homogenate by procedures including chloroform treatment, ammonium sulfate precipitation, ion-exchange column chromatography, and gel filtration. The molecular weight of the purified inhibitor was 34,000 on SDS-PAGE. We determined the amino acid sequence of the N-terminal region of the purified inhibitor to be Glu-Glu-Pro-Trp-Met-Ser-Met-Ser-Ser-Lys-Pro-Lys-Pro-Ile-Glu-. This sequence shows a high homology to a rat arginase, the amino acid sequence of which was predicted from the nucleic acid sequence of cloned rat arginase cDNA. The amino acid sequence of the purified arginase is 6 amino acid residues longer than the predicted one. The purified MLR inhibitor showed a high arginase activity. The inhibition mechanism was studied and it was discovered that L-arginine was depleted in the culture medium, and that the supply of L-arginine to the cell culture caused recovery of the incorporation of tritium thymidine. Here we present evidence that the MLR inhibitor from rat liver homogenate is the liver arginase. It is noteworthy that immune response may be controlled by a liver factor.
Unusual Physical and Chemical Properties of Cu in Ce<sub>1‐x</sub>Cu<sub>x</sub>O<sub>2</sub> Oxides. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Physiologic Assessment of Intrathecal Amitriptyline in Sheep  (1997)

Although other preclinical toxicity studies are necessary before introducing intrathecal amitriptyline for use in humans, this study did not reveal dangerous changes in blood pressure or spinal cord blood flow from this agent.
Reactively sputtered Ru–Si–O films (1999)

Films of Ru–Si–O were synthesized by reactively sputtering a Ru1Si1 target in an Ar/O2 gas mixture. They were characterized in terms of their composition by 2.0 MeV He++4 backscattering spectrometry, their atomic density by thickness measurements combined with backscattering data, their microstructure by x-ray diffraction and transmission electron microscopy, and their electrical resistivity by four-point-probe measurements. The compositions indicate preferential sputtering with ruthenium enrichment of the films, and a saturation level of oxygen is determined at 67 at. % corresponding to the formation of SiO2 and RuO2. X-ray diffraction spectra reveal an amorphous structure for oxygen-saturated and nanocrystals for unsaturated as-deposited films. The crystallization temperature clearly increases with the oxygen concentration of the films, from 500 °C for oxygen-free films to 1000 °C for oxygen-saturated films, when annealed in vacuum for 30 min. Transmission electron micrographs of as-deposited oxygen-saturated films show few nanocrystals of 1–2 nm in diameter in an otherwise amorphous matrix. The atomic density is roughly 8×1022 atom/cm3 for all compositions. The resistivity of the ternary alloys scales with the terminal phases in the ternary phase diagram and reaches a maximum value when the Ru–SiO2 tie line is crossed near 50 at. % oxygen. The films are stable in vacuum up to thermal stressing at 800 °C for 5 h, and their decomposition starts near 1000 °C.
Effect of Process Variables on Electrical Properties of Pb-Alloy Josephson Junctions (1980)

Our studies on the effect of process variables on the electrical properties of Josephson tunnel junctions were directed toward optimization of the process for cryogenic memory applications, for which special importance is placed on the dc Josephson current density j <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> , its stability and reproducibility, and the junction quality. Variables studied included rf voltage, oxygen plasma pressure, the presence of oxygen during deposition of the counter electrode, the composition and surface state of the base electrode, junction geometry, radial position on the wafer, and storage and annealing conditions. Various process adjustments were made in order to obtain acceptable device characteristics. For example, good tunnel characteristics could be obtained using Pb-Au-In alloys if In concentrations > 8 wt% (for a fixed 3% Au concentration) were used in the base electrode. High pressure and low rf voltage during oxidation were preferable, since these conditions led to low annealing factors. We were also able to adjust j <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> locally by irradiation with high-energy (> 5 keV) electrons.
Double electron–electron resonance spin–echo modulation: Spectroscopic measurement of electron spin pair separations in orientationally disordered solids (1993)

A DEER (double electron–electron resonance) spin–echo technique was applied to measure the electron–electron dipolar spectrum of a frozen toluene solution of the biradical, 2,6-bis[(((2,2,5, 5-tetramethyl-1-oxypyrrolin-3-yl)carbonyl)oxy)]-anthracene. Modulation of the DEER spin–echo envelope was observed and identified as originating from the dipolar coupling between the two nitroxide spins of the biradical. Fourier transformation of the modulated components of the echo envelope yielded a dipolar spectrum from which a spin–pair separation of 19.73±0.14 Å was calculated. Constraints on the relative orientation of the two nitroxide spin moieties were obtained by analysis of the effect of the microwave pulse orientational selectivity on the DEER modulation amplitudes. Molecular models of the studied compound exhibit structures that correspond well with the structural information deduced by DEER spectroscopy.
Revolving Credit Card Holders: Who Are They and How Can They Be Identified? (2001)

Abstract All major credit card issuers, to a greater or lesser extent, are holding a portfolio consisting of three types of credit card holder: (i) non-active card holders; (ii) non-interest paying active card holders; and (iii) interest paying active card holders. This article, using two quantitative techniques more commonly associated with credit risk management or credit scoring, is concerned with identifying the characteristics of active card holders with the greatest propensity to revolve (i.e. pay interest). The sample consists of 27,681 bank credit card holders who had held and used their card in the 14 month sample period. Data was available on 313 socio-demographic and behavioural variables for which, a priori, there was good reason to include so as to discriminate between users who paid interest on their outstanding balances (i.e. revolvers) and those who did not. The main result of this research is that the most important discriminating variables are derived from the card holder's behaviour (i.e. cash advances, minimum payment due, interest paid in previous periods). This result is derived from and supported by the two competing techniques used for the analysis: Linear Discriminant Analysis and Logistic Regression.
Dynamic viscosity of ternary mixtures of dichlorodifluoromethane (R-12), chlorodifluoromethane (R-22), and dichlorotetrafluoroethane (R-114) vapors (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamic viscosity of ternary mixtures of dichlorodifluoromethane (R-12), chlorodifluoromethane (R-22), and dichlorotetrafluoroethane (R-114) vaporsBhagwant Singh and M. A. TirunarayananCite this: J. Chem. Eng. Data 1980, 25, 1, 57–59Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/je60084a004https://doi.org/10.1021/je60084a004research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modeled performance of polycrystalline thin‐film tandem solar cells (2002)

Abstract The optimum bandgaps for two‐terminal monolithic multijunction devices have typically been studied under a fixed set of environmental conditions, using ideal device models. This study examines the effects of a realistic dark‐current for typical state‐of‐the‐art thin‐film polycrystalline cells on the optimum energy gap for a series‐connected two‐junction cell. The optimum energy gaps are compared for a series‐connected tandem cell under standard reference conditions and the energy produced for five different reference days where the temperature, spectral irradiance and total irradiance varied. The optimum bandgaps were found to be 1.72 ± 0.02 eV for the top cell and 1.14 ± 0.02 eV for the bottom cell. Published in 2002 by John Wiley & Sons, Ltd.