gebhart/patrepeval huggingface dataset:
<i>ACS Applied Materials & Interfaces</i> and <i>Chemistry of Materials</i> To Exclusively Publish Full Articles in 2019 (2019)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTACS Applied Materials & Interfaces and Chemistry of Materials To Exclusively Publish Full Articles in 2019Please submit letters to ACS Materials Letters, which launches in early 2019Jillian M. BuriakJillian M. BuriakMore by Jillian M. Buriakhttp://orcid.org/0000-0002-9567-4328 and Kirk S. SchanzeKirk S. SchanzeMore by Kirk S. Schanzehttp://orcid.org/0000-0003-3342-4080Cite this: ACS Appl. Mater. Interfaces 2019, 11, 5, 4703–4704Publication Date (Web):January 29, 2019Publication History Published online29 January 2019Published inissue 6 February 2019https://pubs.acs.org/doi/10.1021/acsami.9b00304https://doi.org/10.1021/acsami.9b00304editorialACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2872Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (624 KB) Get e-AlertscloseSUBJECTS:Chemical engineering and industrial chemistry,Interfaces,Materials Get e-Alerts
[Coronary Artery Anastomosis]. (2019)

It is well known that proximal part of a sequential bypass grafting often demonstrates better patency than distal part does due to more favorable hemodynamics of side-to-side anastomosis. Therefore, we adopt side-to-side anastomosis( parallel fashion) even for most distal part of bypass grafting. In addition to superiority in hemodynamics, side-to-side anastomosis (parallel fashion) provides a couple of advantages such as ① easiness in creating a very long opening of the anastomosis, ② compatibility in size (diameter) mismatch between graft conduit and coronary artery, and ③ excellent hemostasis from the suture line. This article describes technical details and tips of side-to-side anastomosis in both parallel fashion and diamond( cross direction) fashion.
Solution-Phase Parallel Synthesis of Acyclic Nucleoside Libraries of Purine, Pyrimidine, and Triazole Acetamides (2014)

Molecular diversity plays a pivotal role in modern drug discovery against phenotypic or enzyme-based targets using high throughput screening technology. Under the auspices of the Pilot Scale Library Program of the NIH Roadmap Initiative, we produced and report herein a diverse library of 181 purine, pyrimidine, and 1,2,4-triazole-N-acetamide analogues which were prepared in a parallel high throughput solution-phase reaction format. A set of assorted amines were reacted with several nucleic acid N-acetic acids utilizing HATU as the coupling reagent to produce diverse acyclic nucleoside N-acetamide analogues. These reactions were performed using 24 well reaction blocks and an automatic reagent-dispensing platform under inert atmosphere. The targeted compounds were purified on an automated purification system using solid sample loading prepacked cartridges and prepacked silica gel columns. All compounds were characterized by NMR and HRMS, and were analyzed for purity by HPLC before submission to the Molecular Libraries Small Molecule Repository (MLSMR) at NIH. Initial screening through the Molecular Libraries Probe Production Centers Network (MLPCN) program, indicates that several analogues showed diverse and interesting biological activities.
Development of the eLen Regulation Database to Support Legislation of Municipalities (2014)

This paper shows the implementation and operation of our eLen regulation database system provided for all of municipalities in Japan. The system is to support legislation of the municipalities with various functions, for instance, cross-searching among many municipalities and automatic composition of comparing tables, which are based on requests obtained by the direct hearing for many municipalities. So far about 700 out of 1,790 municipalities in total have already used the system. Since many municipalities have similar regulations, almost results of search in the system involve many outputs. Therefore, the system has a function to classify the results after preprocessing with using a supercomputer.
Atrial-natriuretic-factor mRNA is developmentally regulated in heart ventricles and actively expressed in cultured ventricular cardiac muscle cells of rat and human. (1988)

Atrial-natriuretic-factor (ANF) mRNA is actively expressed in ventricular heart myocytes of neonatal rats and fetal and young (2.5-year-old) humans. In rat, ANF mRNA transcription is repressed by the 23rd day of postnatal development, and in human it is no longer detected by the 14th year of development. Its expression is observed in atrial myocytes of both of these species at all ages. ANF mRNA is expressed in primary cultures of ventricular cardiac muscle cells prepared from both neonatal-rat and fetal-human hearts. Surprisingly it is also very actively expressed in cultures of adult rat ventricular cardiac muscle cells. The effect of several hormones on the expression of ANF mRNA in rat and human myocyte cultures was evaluated. These studies demonstrate that ANF mRNA transcription is developmentally regulated in both rat and human heart ventricles and suggest that ventricular cardiac muscle-cell cultures may be useful in studying the regulation of the expression of this gene.
Defining a new nomenclature for the structures of active and inactive kinases (2019)

Targeting protein kinases is an important strategy for intervention in cancer. Inhibitors are directed at the active conformation or a variety of inactive conformations. While attempts have been made to classify these conformations, a structurally rigorous catalog of states has not been achieved. The kinase activation loop is crucial for catalysis and begins with the conserved DFGmotif. This motif is observed in two major classes of conformations, DFGin-a set of active and inactive conformations where the Phe residue is in contact with the C-helix of the N-terminal lobe-and DFGout-an inactive form where Phe occupies the ATP site exposing the C-helix pocket. We have developed a clustering of kinase conformations based on the location of the Phe side chain (DFGin, DFGout, and DFGinter or intermediate) and the backbone dihedral angles of the sequence X-D-F, where X is the residue before the DFGmotif, and the DFG-Phe side-chain rotamer, utilizing a density-based clustering algorithm. We have identified eight distinct conformations and labeled them based on the Ramachandran regions (A, alpha; B, beta; L, left) of the XDF motif and the Phe rotamer (minus, plus, trans). Our clustering divides the DFGin group into six clusters including BLAminus, which contains active structures, and two common inactive forms, BLBplus and ABAminus. DFGout structures are predominantly in the BBAminus conformation, which is essentially required for binding type II inhibitors. The inactive conformations have specific features that make them unable to bind ATP, magnesium, and/or substrates. Our structurally intuitive nomenclature will aid in understanding the conformational dynamics of kinases and structure-based development of kinase drugs.
Optimized programming algorithm for cylindrical and directional deep brain stimulation electrodes (2017)

This DBS programming algorithm can be applied to cylindrical electrodes as well as novel directional leads that are too complex with modern technology to be manually programmed. This algorithm may reduce clinical programming time and encourage the use of directional leads, since they activate a larger volume of the target area than cylindrical electrodes in central and off-target lead placements.
An automated molecular test for Mycobacterium tuberculosis and resistance to rifampin (Xpert MTB/RIF) is sensitive and can be carried out in less than 2 h (2010)

Commentary on: 1. Boehme CC, 2. Nabeta P, 3. Hillemann D, 4. et al . Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med 2010;363:1005–15. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] In parts of Eastern Europe and the developing world, where a lack of diagnostic tuberculosis (TB) laboratory facilities exist, the prevalence of multidrug and extensive drug resistance is rising. Conventional sputum microscopy, using Ziehl–Neelsen or auramine stains, have low sensitivities, and the accuracy of these results rely on the skill of technical staff. Because the doubling time of Mycobacterium tuberculosis is slower than conventional bacteria, considerable delays occur in obtaining mycobacterial speciation and susceptibility results. In patients with drug-resistant TB, suboptimal treatment results in worse clinical outcomes and inadequate treatment leads to failure to control disease and increases the risk of transmission to close contacts.1 In a recently published paper, Boehme and colleagues investigated the utility of … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DBoehme%26rft.auinit1%253DC.%2BC.%26rft.volume%253D363%26rft.issue%253D11%26rft.spage%253D1005%26rft.epage%253D1015%26rft.atitle%253DRapid%2Bmolecular%2Bdetection%2Bof%2Btuberculosis%2Band%2Brifampin%2Bresistance.%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa0907847%26rft_id%253Dinfo%253Apmid%252F20825313%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa0907847&link_type=DOI [3]: /lookup/external-ref?access_num=20825313&link_type=MED&atom=%2Febmed%2F16%2F1%2F19.atom [4]: /lookup/external-ref?access_num=000281609700004&link_type=ISI
Exploring Indirect Sources of Human Exposure to Perfluoroalkyl Carboxylates (PFCAs): Evaluating Uptake, Elimination, and Biotransformation of Polyfluoroalkyl Phosphate Esters (PAPs) in the Rat (2010)

Using experimentally derived biotransformation yields, perfluorooctanoic acid (PFOA) sera concentrations were predicted from the biotransformation of 8:2 diPAP at concentrations observed in human serum. Because of the long human serum half-life of PFOA, biotransformation of diPAP even with low-level exposure could over time result in significant exposure to PFOA. Although humans are exposed directly to PFCAs in food and dust, the pharmacokinetic parameters determined here suggest that PAP exposure should be considered a significant indirect source of human PFCA contamination.
[Effects of Tongxinluo on cell viability and tissue factor in AngII induced vascular endothelial cells]. (2007)

Up-regulating NOS-NO signaling may be the mechanism of Tongxinluo on cell viability and TF in AngII induced vacular endothelial cells.
Secure Overlay Cloud Storage with Access Control and Assured Deletion (2012)

We can now outsource data backups off-site to third-party cloud storage services so as to reduce data management costs. However, we must provide security guarantees for the outsourced data, which is now maintained by third parties. We design and implement FADE, a secure overlay cloud storage system that achieves fine-grained, policy-based access control and file assured deletion. It associates outsourced files with file access policies, and assuredly deletes files to make them unrecoverable to anyone upon revocations of file access policies. To achieve such security goals, FADE is built upon a set of cryptographic key operations that are self-maintained by a quorum of key managers that are independent of third-party clouds. In particular, FADE acts as an overlay system that works seamlessly atop today's cloud storage services. We implement a proof-of-concept prototype of FADE atop Amazon S3, one of today's cloud storage services. We conduct extensive empirical studies, and demonstrate that FADE provides security protection for outsourced data, while introducing only minimal performance and monetary cost overhead. Our work provides insights of how to incorporate value-added security features into today's cloud storage services.
Progression of Autoimmune Hepatitis is Mediated by IL-18-Producing Dendritic Cells and Hepatic CXCL9 Expression in Mice (2014)

These data suggest that, in our mouse model, fatal progression of AIH is mediated by IL-18-dependent differentiation of T cells into Th1 cells and effector T cells, respectively, and that CXCR3-CXCL9 axis-dependent migration of those T cells is crucial for fatal progression.
SPECT dual-energy-window Compton correction: scatter multiplier required for quantification. (1990)

The dual-energy window Compton-scattering correction technique is defined here especially for accurate quantification of focal regions having higher than average uptake. The quantification is relative to a known-activity reference source. The scatter multiplier ("k" value) is determined for a radioactive 99mTc sphere on or off the axis of a cylinder containing water with or without background. Both maximum likelihood and filtered-backprojection reconstruction are employed. Either projections or tomograms are corrected. With tight regions of interest, there is a tendency for the requisite "k" value to be slightly lower as the diameter of the cylinder is increased. Neither sphere location nor background perturbs "k", however, so a constant value is a good, first approximation. Then a two-sphere validation test yields an accuracy of 8% with subtracted-tomograms ("k" = 1.30) and 2% with subtracted-projections ("k" = 1.20). With a reference-source region of interest which is four times larger, "k" is reduced and also now depends on background. Although equivalent quantitatively, maximum likelihood is preferable to filtered backprojection with Chang attenuation correction since it produces a less-noisy image.
New stage in living cationic polymerization: An array of effective Lewis acid catalysts and fast living polymerization in seconds (2007)

Abstract Our recent extensive research on Lewis acid catalysts with a weak base for the cationic polymerization of vinyl ethers led to unprecedented living reaction systems: fast living polymerization within 1–3 s; a wide choice of metal halides containing Al, Sn, Fe, Ti, Zr, Hf, Zn, Ga, In, Si, Ge, and Bi; and heterogeneously catalyzed living polymerization with Fe 2 O 3 . The use of added bases for the stabilization of the propagating carbocation and the appropriate selection of Lewis acid catalysts were crucial to the success of such new types of living polymerizations. In addition, the base‐stabilized living polymerization allowed the quantitative synthesis of star‐shaped polymers with a narrow molecular weight distribution via polymer‐linking reactions and the precision synthesis and self‐assembly of stimuli‐responsive block copolymers. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 1801–1813, 2007.
Moiré artifacts reduction in Talbot-Lau X-ray phase contrast imaging using a three-step iterative approach (2022)

Talbot-Lau X-ray phase contrast imaging is a promising technique in biological imaging since it can provide absorption, differential phase contrast, and dark-field images simultaneously. However, high accuracy motorized translation stages and high stability of the imaging system are needed to avoid moiré artifacts in the reconstructed images. In this work, the effects of the stepping errors and the dose fluctuations on the transmission, differential phase contrast, and dark-field images are theoretically derived and systematically summarized. A novel three-step iterative method is designed for image reconstruction in Talbot-Lau interferometry with phase-stepping errors and dose fluctuations. Phase distributions, phase-stepping errors, and dose fluctuation coefficients are iteratively updated via the least square method until the convergence criteria are met. Moiré artifacts are mostly reduced via the proposed method in both the numerical simulations and experiments. The reconstructed images are highly coincident with the ground truth, which verifies the high accuracy of this method. The proposed algorithm is also compared with other moiré artifacts reduction algorithms, which further demonstrates the high precision of this algorithm. This work is beneficial for reducing the strict requirements for the hardware system in the conventional Talbot-Lau interferometry, such as the high accuracy motorized stages and the X-ray tube with high stability, which is significant for advancing the X-ray phase contrast imaging towards the practical medical applications.
A Simple and Effective Method to Evaluate Peak Flowmeters (1996)

OBJECTIVE: Peak flowmeters have been widely used to monitor the course of asthma. The objective of this study was to develop a simple, convenient and effective method to evaluate these devices routinely. METHODS: A rubber band‐driven 3 L syringe was used to generate airflows, and a pneumotachometer was connected in series with the peak flowmeter as a standard. Waveforms were recorded and compared with maximal expiratory curves. The accuracy of peak flowmeters was analyzed by linear regression and by calculating the percentage of the difference measured by the flowmeter (F) and the pneumotachometer (P), expressed as (F‐‐P)/P (%). RESULTS: This set‐up generated waveforms similar to the initial phase of maximal expiratory curves, with linear increment of peak flow rates up to 790 L/min (R=0.999, PÃ0.001). Both waveforms and peak flow rates were highly reproducible with coefficients of variation less than 5% throughout the full range tested. Fourteen peak flowmeters from seven different models were evaluated. Most of these devices revealed a satisfactory linear relationship with the pneumotachometer. The interdevice variation of different models and variations of each device at different flow rates were clearly demonstrated by (F‐‐P)/P (%). CONCLUSION: The system developed in the present study can be easily set up and used to evaluate the performance of peak flowmeters.
Fast iterative, coupled-integral-equation technique for inhomogeneous profiled and periodic slabs (2005)

A fast coupled-integral-equation (CIE) technique is developed to compute the plane-TE-wave scattering by a wide class of periodic 2D inhomogeneous structures with curvilinear boundaries, which includes finite-thickness relief and rod gratings made of homogeneous material as special cases. The CIEs in the spectral domain are derived from the standard volume electric field integral equation. The kernel of the CIEs is of Picard type and offers therefore the possibility of deriving recursions, which allow the computation of the convolution integrals occurring in the CIEs with linear amounts of arithmetic complexity and memory. To utilize this advantage, the CIEs are solved iteratively. We apply the biconjugate gradient stabilized method. To make the iterative solution process faster, an efficient preconditioning operator (PO) is proposed that is based on a formal analytical inversion of the CIEs. The application of the PO also takes only linear complexity and memory. Numerical studies are carried out to demonstrate the potential and flexibility of the CIE technique proposed. Though the best efficiency and accuracy are observed at either low permittivity contrast or high conductivity, the technique can be used in a wide range of variation of material parameters of the structures including when they contain components made of both dielectrics with high permittivity and typical metals.
The Role of Slow Potassium Current in Nerve Conduction Block Induced by High-Frequency Biphasic Electrical Current (2008)

The role of slow potassium current in nerve conduction block induced by high-frequency biphasic electrical current was analyzed using a lumped circuit model of a myelinated axon based on the Schwarz-Reid-Bostock model. The results indicate that nerve conduction block at stimulation frequencies above 4 kHz is due to constant activation of both fast and slow potassium channels, but the block at stimulation frequencies below 4 kHz could be due to either anodal or cathodal dc block depending on the time of the action potential arriving at the block electrode. When stimulation frequency was above 4 kHz, the slow potassium current was about 3.5 to 6.5 times greater than the fast potassium current at blocking threshold, indicating that the slow potassium current played a more dominant role than the fast potassium current. The blocking location moved from the node under the blocking electrode to a nearby node as the stimulation intensity increased. This simulation study reveals that in mammalian myelinated axons, the slow potassium current probably plays a critical role in the nerve conduction block induced by high-frequency biphasic electrical current.
Cyclic Monophosphate Prodrugs of Base‐Modified 2′‐C‐Methyl Ribonucleosides as Potent Inhibitors of Hepatitis C Virus RNA Replication. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Integrated Power System Design for Offshore Energy Vessels and Deepwater Drilling Rigs (2012)

As exploration for new offshore oil and gas fields pushes into ever deeper water, upstream assets require ever more power for marine operations and commercial activities related to exploration, development, completions, and production. This paper will briefly introduce the different activities and conditions required for the energy assets, some of the current designs, and respective typical power plant characteristics. Comparisons will be also discussed with how drilling power plants are similar and different in design to other power plants such as production platforms and integrated electric military and commercial vessels. To successfully design the next-generation offshore energy vessels, electrical engineers will be required to leverage best practices and technology across all marine-integrated markets. An in-depth understanding of the operational mission of the vessel and the equipment required is absolutely necessary to ensure optimization of the plant and efficient distribution.