gebhart/patrepeval huggingface dataset:
Principles and characteristics of a new generation plasma immersion ion implanter (1997)

A new generation multipurpose plasma immersion ion implanter (PIII) was custom designed, constructed, and installed in the City University of Hong Kong. The system is designed for general R&D applications in metallurgy, tribology, surface modification, and fabrication of novel materials. Using the new rf ion source in conjunction with the internal antenna system, the plasma density achieves excellent uniformity both laterally and axially. The system also incorporates two metal sources, including four metal arc sources and a sputtering electrode, so that multiple metal deposition and implantation steps can be performed in succession in the same equipment without exposing the samples to air. This capability can be critical to the study of surface properties and corrosion resistance. This article describes the design objectives, the novel features, and the characteristics of this new generation PIII equipment.
CD30 expression in nonlymphomatous malignancies. (2012)

3069 Background: CD30 is commonly expressed in Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), and testicular embryonal carcinoma. Expression of CD30 in other solid tumors and non-lymphomatous malignancies has been reported but not investigated systematically. CD30 is the target of brentuximab vedotin (Adcetris), an antibody drug conjugate (ADC) that is approved for the treatment of patients with relapsed HL and systemic ALCL after failure of other therapies. A study was initiated to determine the incidence of CD30 expression in non-lymphomatous malignancies and to identify patients who may be candidates for treatment with brentuximab vedotin. Methods: Patients with non-lymphomatous malignancies were eligible for screening if they were relapsed or refractory to previous therapy or had no effective treatment options available. Archived tissue from solid tumors was tested for CD30 expression by immunohistochemistry (IHC); fresh bone marrow or blood samples from multiple myeloma or leukemia patients were tested by flow cytometry. Patients were considered CD30 positive and eligible for a companion treatment protocol with brentuximab vedotin if ≥10% of malignant cells stained positive by IHC or ≥20% by flow cytometry. Results: At this interim analysis, a total of 875 patients have been tested for CD30 expression: 95% had solid tumors, 3% had leukemia, and 2% had multiple myeloma. Twenty-two patients (2.5%) were CD30 positive, including 7 of 94 patients with ovarian cancer (7%), 5 of 20 with melanoma (25%), 2 of 5 with mesothelioma (40%), 1 of 4 with skin squamous cell carcinoma (25%), 2 of 41 with triple negative breast cancer (5%), 1 of 37 with pancreatic cancer (3%), 1 of 26 with small cell lung cancer (4%), and 1 of 3 with anal cancer (33%), and thyroid carcinoma (33%). One patient was identified with CD30-positive mast cell leukemia. In positive patients, the percent of CD30-positive malignant cells varied between 10 and 80%. Conclusions: CD30 expression was observed in multiple types of non-lymphomatous malignancies, thereby identifying additional populations who may be candidates for treatment with a CD30-targeted ADC, such as brentuximab vedotin. A companion clinical trial with brentuximab vedotin is currently ongoing.
A novel algorithm of lane detection addressing varied scenarios of curved and dashed lanemarks (2015)

Lane detection is a critical step in advanced driver assistance systems (ADAS). The detected lane information is used by later modules of warning and controlling the differential brake and steering angle. Here we propose an efficient algorithm for detecting accurate lane inbounds under varying illumination and road conditions like curvy, straight and dashed lane markings, deterministically. The current method uses edges extracted from frames and lane mask information extracted from spatial lane stripes through adaptive figure-ground segregation to determine the lane bounds. The proposed method has been extensively validated for varying real time scenarios against the state-of-art methods of lane detection.
Non-Contact Simultaneous Photoplethysmogram and Ballistocardiogram Video Recording towards Real-Time Blood Pressure and Abnormal Heart Rhythm Monitoring (2017)

We present a video-based method to monitor blood pressure by analyzing pulse transit time (PTT). The PTT is determined from ballistocardiogram (BCG) and photoplethysmogram (PPG), which are recorded simultaneously using a single camera. The measured blood pressure changes are compared with those measured with a cuff-based reference blood pressure monitor. In addition to blood pressure, premature ventricular contraction (PVC) is also observed from both PPG and BCG waveforms. The method provides a non-contact solution towards real-time blood pressure and abnormal heart rhythm monitoring of an individual under normal living conditions without his/her conscious attention.
Design, Synthesis, and Evaluation of Aza-Peptide Epoxides as Selective and Potent Inhibitors of Caspases-1, -3, -6, and -8 (2004)

Aza-peptide epoxides, a novel class of irreversible protease inhibitors, are specific for the clan CD cysteine proteases. Aza-peptide epoxides with an aza-Asp residue at P1 are excellent irreversible inhibitors of caspases-1, -3, -6, and -8 with second-order inhibition rates up to 1 910 000 M(-1) s(-1). In general, the order of reactivity of aza-peptide epoxides is S,S > R,R > trans > cis. Interestingly, some of the R,R epoxides while being less potent are actually more selective than the S,S epoxides. Our aza-peptide epoxides designed for caspases are stable, potent, and specific inhibitors, as they show little to no inhibition of other proteases such as the aspartyl proteases porcine pepsin, human cathepsin D, plasmepsin 2 from P. falciparum, HIV-1 protease, and the secreted aspartic proteinase 2 (SAP-2) from Candida albicans; the serine proteases granzyme B and alpha-chymotrypsin; and the cysteine proteases cathepsin B and papain (clan CA), and legumain (clan CD).
DurIAN-SC: Duration Informed Attention Network Based Singing Voice Conversion System (2020)

Singing voice conversion is converting the timbre in the source singing to the target speaker's voice while keeping singing content the same. However, singing data for target speaker is much more difficult to collect compared with normal speech this http URL this paper, we introduce a singing voice conversion algorithm that is capable of generating high quality target speaker's singing using only his/her normal speech data. First, we manage to integrate the training and conversion process of speech and singing into one framework by unifying the features used in standard speech synthesis system and singing synthesis system. In this way, normal speech data can also contribute to singing voice conversion training, making the singing voice conversion system more robust especially when the singing database is small.Moreover, in order to achieve one-shot singing voice conversion, a speaker embedding module is developed using both speech and singing data, which provides target speaker identify information during conversion. Experiments indicate proposed sing conversion system can convert source singing to target speaker's high-quality singing with only 20 seconds of target speaker's enrollment speech data.
Improving Index Performance through Prefetching (CMU-CS-00-177) (2018)

This paper proposes and evaluates Prefetching B+-Trees (pB+-Trees), which use prefetching to accelerate two important operations on B+-Tree indices: searches and range scans. To accelerate searches, pB+-Trees use prefetching to effectively create wider nodes than the natural data transfer size: e.g., eight vs. one cache lines or disk pages. These wider nodes reduce the height of the B+-Tree, thereby decreasing the number of expensive misses when going from parent tochild without significantly increasing the cost of fetching a given node. Our results show that this technique speeds up search and update times by a factor of 1.2-1.5 for main-memory B+-Trees. In addition, it outperforms and is complementary to "Cache-Sensitive B+-Trees." To accelerate range scans, pB+-Trees provide arrays of pointers to their leaf nodes. These allow the pB+-Tree to prefetch arbitrarily far ahead, even for nonclustered indices, thereby hiding the normally expensive cache misses associated with traversing the leaves within the range. Our results show that this technique yields over a sixfold speedup on range scans of 1000+ keys. Although our experimental evaluation focuses on main memory databases, the techniques that we propose are also applicable to hiding disk latency.
Impact of electrode design and surgical approach on scalar location and cochlear implant outcomes (2014)

2b.
Charged amino acid residues of human immunodeficiency virus type 1 nucleocapsid p7 protein involved in RNA packaging and infectivity (1996)

Interaction of the human immunodeficiency virus type 1 (HIV-1) Gag precursor polyprotein (Pr55Gag) with the viral genomic RNA is required for retroviral replication. Mutations that reduce RNA packaging efficiency have been localized to the highly basic nucleocapsid (NC) p7 domain of Pr55Gag, but the importance of the basic amino acid residues in specific viral RNA encapsidation and infectivity has not been thoroughly investigated in vivo. We have systematically substituted the positively charged residues of the NC domain of Pr55Gag in an HIV-1 viral clone by using alanine scanning mutagenesis and have assayed the effects of these mutations on virus replication, particle formation, and RNA packaging in vivo. Analysis of viral clones with single substitutions revealed that certain charged amino acid residues are more critical for RNA packaging efficiency and infectivity than others. Analysis of viral clones with multiple substitutions indicates that the presence of positive charge in each of three independent domains--the zinc-binding domains, the basic region that links them, and the residues that Hank the two zinc-binding domains--is necessary for efficient HIV-1 RNA packaging. Finally, we note that some mutations affect virus replication more drastically than RNA incorporation, providing in vivo evidence for the hypothesis that NC p7 may be involved in aspects of the HIV life cycle in addition to RNA packaging.
Selective removal of acetylenes from olefin mixtures through specific physicochemical interactions of ionic liquids with acetylenes (2009)

Imidazolium-based ionic liquids (ILs) bearing an alkylphosphite anion, were highly efficient for the selective removal of acetylenes in olefins. Comparison of solubility data at 313 K and at atmospheric pressure shows that the solubilities of acetylene and propyne in 1,3-dimethylimidazolium methylphosphite ([DMIM][MeHPO(3)]) are about 45 and 20 times higher than those of ethylene and propylene, respectively. Computational and (1)H NMR results clearly demonstrate that there are substantial interactions between the acidic hydrogen atom or atoms of acetylenes and the phosphite anion.
Ultra‐High‐Aspect‐Ratio Titania Nanotubes (2007)

Ultrahigh-aspect-ratio titania nanotubes are fabricated electrochemically in organic-acid-containing chlorine salts. The tubes (see figure) are several tens of micrometers in length and only about 20 nm in diameter. The use of organic acids as anodic electrolyte combined with the vigorous chlorine chemistry result in the incorporation of a significant amount of carbon into the nanotubes. Such high-aspect-ratio nanotubes are shown to have enhanced visible-light-harvesting characteristics.
Standoff terahertz wave generation from two-color laser-induced plasma at 30 meters in ambient air (2011)

Terahertz wave generation and detection using gaseous medium as both the THz wave emitter and sensor has drawn a great deal of attention. We report intense THz wave generation from two-color laser-induced air plasma at standoff distances of up to 30 m with peak THz electric field exceeding 1 kV/cm.
Development of a Grp94 inhibitor (2012)

Heat shock protein 90 (Hsp90) represents a promising therapeutic target for the treatment of cancer and other diseases. Unfortunately, results from clinical trials have been disappointing as off-target effects and toxicities have been observed. These detriments may be a consequence of pan-Hsp90 inhibition, as all clinically evaluated Hsp90 inhibitors simultaneously disrupt all four human Hsp90 isoforms. Using a structure-based approach, we designed an inhibitor of Grp94, the ER-resident Hsp90. The effect manifested by compound 2 on several Grp94 and Hsp90α/β (cytosolic isoforms) clients were investigated. Compound 2 prevented intracellular trafficking of the Toll receptor, inhibited the secretion of IGF-II, affected the conformation of Grp94, and suppressed Drosophila larval growth, all Grp94-dependent processes. In contrast, compound 2 had no effect on cell viability or cytosolic Hsp90α/β client proteins at similar concentrations. The design, synthesis, and evaluation of 2 are described herein.
Automatic phonetic baseform determination (1991)

The authors describe a series of experiments in which the phonetic baseform is deduced automatically for new words by utilizing actual utterances of the new word in conjunction with a set of automatically derived spelling-to-sound rules. Recognition performance was evaluated on new words spoken by two different speakers when the phonetic baseforms were extracted via the above approach. The error rates on these new words were found to be comparable to or better than when the phonetic baseforms were derived by hand, thus validating the basic approach.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Masterless multirate control of parallel DC-DC converters (2010)

This paper introduces a new masterless multirate control scheme for current share in DC-DC converters. Comprising of a multirate digital controller, decoupling interactions between control loops, a single wire digital communication bus, facilitating simple and reliable communication between devices, and a modular current share architecture. Results show excellent static and dynamic current matching, and have been commercially proven.
Extreme-ultraviolet plasma source with full, infrared to vacuum ultraviolet spectral filtering, and with power recycling (2016)

A laser-produced plasma source for extreme-ultraviolet (EUV) lithography conventionally uses a diffraction grating on the collection mirror for spectral purity filtering via diffractive scattering of infrared (IR) radiation. This paper proposes an alternative approach in which an EUV-blazed diffraction grating diverts in-band EUV radiation into the intermediate-focus aperture, rather than diverting IR out of the aperture. The full out-of-band spectrum, from long-wave IR to vacuum ultraviolet, can be fully excluded by this method regardless of whether the radiation is undiffracted or diffractively scattered by the grating. Much of the out-of-band radiation—especially the IR—is undiffracted, and this radiation can be efficiently returned to the plasma via retroreflection to enhance IR-to-EUV conversion. Plasma-emitted radiation that does not intercept the collection mirror can also be recycled back to the plasma via retroreflection to further boost EUV output.
Rectified Diode Response of a Quantum Cascade Laser Integrated Terahertz Transceiver (2012)

We characterized the rectified response of a diode integrated on a terahertz quantum cascade laser transceiver. The diode response is consistent with its I-V characteristics and reflects the complex Fabry-Perot laser cavity mode spectrum.
Minimizing the Page Close Penalty: Indexing Memory Banks Revisited (2003)

This paper introduces several new techniques to optimize the use of page mode and prefetching to improve the performance of a memory system. We start by improving the basic bank indexing scheme, allowing higher hit rates to be attained with a smaller number of banks. Next, we introduce the idea of keeping only a subset of the possible banks open. When this is done, only a small fraction of page-mode misses are to open banks, while the banks that are open capture the great majority of the possible page-mode and sequential prefetching hits. This both improves the performance of workloads with a high hit rate and signi cantly decreases the risk of page misses under di cult or random workloads. This idea might also simplify the memory controller. In our workloads, using only eight bank controllers on a memory system supporting only 32 banks, 55% of the all read references were satis ed by data already in the bus drivers, requiring no DRAM latency at all. We compare di erent techniques for mapping a smaller number of bank controllers onto a larger number of memory banks, and show that using a fully-associative mapping works best. The report nishes with a number of auxilliary investigations. We show that there is a slight advantage to not associating the prefetch bu ers with the bank controllers, but rather using a separate LRU prefetch cache. We show that DRAM refresh has a small impact on the results, while the cache line size has a large impact.
New Methodology to Obtain a Calibration Model for Noninvasive Near-Infrared Blood Glucose Monitoring (2006)

This paper reports new methodology to obtain a calibration model for noninvasive blood glucose monitoring using diffuse reflectance near-infrared (NIR) spectroscopy. Conventional studies of noninvasive blood glucose monitoring with NIR spectroscopy use a calibration model developed by in vivo experimental data sets. In order to create a calibration model, we have used a numerical simulation of light propagation in skin tissue to obtain simulated NIR diffuse reflectance spectra. The numerical simulation method enables us to design parameters affecting the prediction of blood glucose levels and their variation ranges for a data set to create a calibration model using multivariate analysis without any in vivo experiments in advance. By designing the parameters and their variation ranges appropriately, we can prevent a calibration model from chance temporal correlations that are often observed in conventional studies using NIR spectroscopy. The calibration model (regression coefficient vector) obtained by the numerical simulation has a characteristic positive peak at the wavelength around 1600 nm. This characteristic feature of the regression coefficient vector is very similar to those obtained by our previous in vitro and in vivo experimental studies. This positive peak at around 1600 nm also corresponds to the characteristic absorption band of glucose. The present study has reinforced that the characteristic absorbance of glucose at around 1600 nm is useful to predict the blood glucose level by diffuse reflectance NIR spectroscopy. We have validated this new calibration methodology using in vivo experiments. As a result, we obtained a coefficient of determination, r 2 , of 0.87 and a standard error of prediction (SEP) of 12.3 mg/dL between the predicted blood glucose levels and the reference blood glucose levels for all the experiments we have conducted. These results of in vivo experiments indicate that if the parameters and their vibration ranges are appropriately taken into account in a numerical simulation, the new calibration methodology provides us with a very good calibration model that can predict blood glucose levels with small errors without conducting any experiments in advance to create a calibration model for each individual patient. This new calibration methodology using numerical simulation has promising potential for NIR spectroscopy, especially for noninvasive blood glucose monitoring.
Reusable cryogenic foam insulation for advanced aerospace vehicles (1991)

Future high-speed aircraft and aerospace vehicles using cryogenic propellants will require an advanced reusable insulation system for the propellant tank structure. This cryogenic insulation system must be lightweight, structurally and thermally efficient, and capable of multiple reuse without cracking or degraded performance. This paper presents recent progress in the development of a reusable cryogenic foam insulation system having a maximum service temperature of 400 F. The system consists of preshaped, precut blocks of rigid polymethacrylimide foam insulation, wrapped with a high-temperature Kapton and aluminum foil vapor barrier which is adhesively bonded to the propellant tank wall.
An efficient ADMM-based sparse reconstruction strategy for multi-level sampled MRI (2014)

Sparsity-driven image reconstruction is a promising paradigm for improving the spatial, temporal, and contrast resolution in magnetic resonance imaging (MRI). However, high computational expense continues to inhibit the translation of these techniques into routine clinical practice. In many MRI acquisition protocols (e.g., time-resolved CAPR), the sampling operator can be factored into a uniform and non-uniform component. In this work, we present a novel alternating direction method-of-multipliers (ADMM) strategy for sparse reconstruction of multilevel sampled Cartesian SENSE-type MRI data, and discuss how this framework enables certain operations to be computed once offline and recycled during the reconstruction process rather than repeated at every iteration. We then demonstrate that this algorithmic framework enables sparse reconstruction of 3D contrast-enhanced MR angiogram (CE-MRA) time-series in just several minutes (which is clinically practical) rather than the several hours previously required.
Unique intermolecular bactericidal epitope involving the homosialopolysaccharide capsule on the cell surface of group B <i>Neisseria meningitidis</i> and <i>Escherichia coli</i> K1. (1989)

The N-propionylated group B meningococcal polysaccharide mimics a unique bactericidal epitope on the surface of group B meningococci and Escherichia coli K1. This was confirmed when both the above organisms were able to absorb the bactericidal antibodies from a mouse-anti-N-propionylated group B meningococcal polysaccharide-tetanus toxoid conjugate serum. By using affinity columns it was possible to divide the conjugate antiserum into three distinct populations of both group B polysaccharide cross-reactive and non-cross-reactive antibodies, one of which contained most of the bactericidal activity. The cross-reactive (IgG1) antibodies were absorbed by an affinity column in which the group B polysaccharide was linked to the solid support by a long spacer arm, thereby isolating a population of non-cross-reactive (IgG1) antibodies. Surprisingly the above column also retained another population of non-cross-reactive (IgG2a) and (IgG2b) antibodies which contained most of the bactericidal activity. These latter antibodies were not absorbed by a similar group B polysaccharide-affinity column in which a short spacer arm was employed. Thus the above experiments not only effected a separation of highly bactericidal antibodies but also provided evidence that the long spacer arm is functional in the binding of the bactericidal antibodies to the affinity column. This indicates that the bactericidal epitope is mimicked by the group B polysaccharide in the presence of the long spacer arm, which supports the hypothesis that the epitope is polysaccharide-associated and is probably intermolecular in nature.