gebhart/patrepeval huggingface dataset:
Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry (2009)

Although complement lysis is frequently used for the purification of lymphocyte subpopulations in vitro, how lymphocytes escape complement attack in vivo has not been clearly delineated. Here, we show that conditional gene targeting of a murine membrane complement regulator Crry on thymocytes led to complement-dependent peripheral T-cell lymphopenia. Notably, despite evidence of hypersensitivity to complement attack, Crry-deficient T cells escaped complement injury and developed normally in the thymus, because of low intrathymic complement activity. Crry-deficient T cells were eliminated in the periphery by a C3- and macrophage-mediated but C5-independent mechanism. Thus, Crry is essential for mature T-cell survival in the periphery but not for lymphogenesis in the thymus. The observation that the thymus is a complement-privileged site may have implications for complement-based antitumor therapies.
Recovery of Volatile Products from Dilute High-Fouling Process Streams (2000)

As biomass hydrolysis and fermentation technologies approach commercial viability, advancements in product recovery technologies will be required. For cases in which fermentation products are more volatile than water, recovery by distillation is often the technology of choice. Distillation technologies that will allow the economic recovery of dilute volatile products from streams containing a variety of impurities have been developed and commercially demonstrated. Distillation tower and tray designs, along with specialized heat-exchanger designs, allowing for extended processing intervals on solutions containing lignocellulosic residues, organic acids, and inorganic salts concentrations >100 g/L are in commercial operation. In the case of ethanol, distillation energy consumption efficiencies for processing solutions containing <40 g/L of desired product can approach demonstrated energy consumption efficiencies for solutions containing concentrations >120 g/L. These proprietary technologies have been applied individually at commercial scale, and designs have been developed that incorporate the combined technologies with only a marginal increase in capital investment compared to traditional methods.
Encapsulation of BSA using a modified W/O/O emulsion solvent removal method (2006)

A systematic investigation of protein encapsulation in polylactic-co-glycolic-acid (PLGA) was carried out using the formation of a w/o/o emulsion followed by solvent removal. Various factors were studied, including composition of the suspension medium and the relative amounts of aqueous phase containing protein to polymer solution. High yields of microsphere fabrication were achieved by using silicon oil containing methylene chloride as a suspension medium instead of pure silicon oil, with minimal loss of polymer and protein drug (<2%). The amount of aqueous phase influenced the process and successful encapsulation was obtained if the volume ratios of aqueous phase to polymer solution were less than 5% (v/v) at a wide range of polymer concentration (2-15% g ml-1). Protein encapsulation by this w/o/o emulsion and solvent removal method has a high yield of microsphere fabrication and protein encapsulation (98%). In addition, it provides an easy way to control the release rate of protein encapsulated in microspheres by modulating their porosity in fabrication process.
Full-Duplex Wireless-Powered Relay With Self-Energy Recycling (2015)

This letter studies a wireless-powered amplify-and-forward relaying system, where an energy-constrained relay node assists the information transmission from the source to the destination using the energy harvested from the source. We propose a novel two-phase protocol for efficient energy transfer and information relaying, in which the relay operates in full-duplex mode with simultaneous energy harvesting and information transmission. Compared with the existing protocols, the proposed design possesses two main advantages: 1) it ensures uninterrupted information transmission since no time switching or power splitting is needed at the relay for energy harvesting; and 2) it enables the so-called self-energy recycling, i.e., part of the energy (loop energy) that is used for information transmission by the relay can be harvested and reused in addition to the dedicated energy sent by the source. Under the multiple-input single-output (MISO) channel setup, the optimal power allocation and beamforming design at the relay are derived. Numerical results show a significant throughput gain achieved by our proposed design over the existing time switching based relay protocol.
Peripheral Blood Cytokine Profiling During Pregnancy and Post‐partum Periods (2010)

Pregnancy-associated changes to steady state serum cytokines may have important immunologic consequence.
SiGe fast-switching power diodes (2002)

SiGe is widely used in high-frequency bipolar transistors because of its low bandgap and compatibility with silicon. Here we exploit the same benefits of SiGe in a new application area, namely ultrafast power rectifiers. We have produced discrete p/sup +/(SiGe)-n/sup -/n/sup ++/ diodes with low forward voltage drop, low stored charge, and a soft recovery. The performance far exceeds that of conventional devices. These improvements are achieved without resorting to lifetime killing and thus the devices can be easily integrated into power ICs.
Evaluation of figure accuracy of Wolter mirror fabricated by electroforming (2016)

The Wolter mirror is a promising imaging device for soft x-ray microscopy owing to its excellent characteristics. Its annular aperture enables high-NA design while maintaining high photon transfer efficiency. However, its deep and narrow cylinder-like shape makes its fabrication difficult. Despite its long history, the Wolter mirror has not been practically used for high-resolution microscopy. We have been developing a fabrication process for grazing incidence mirrors with rotationally symmetric shapes. The mirrors are replicated from precisely machined mandrels. We employ electroforming as a replication method with high replication accuracy and reproductivity. Here, we report the first fabrication of a Wolter mirror and discuss the replication quality in electroforming. The imaging quality of Wolter mirror is also evaluated in an observation experiment using a visible-light microscope.
Characterization of a resonant bending fatigue test setup for pipes (2011)

This paper discusses the resonant bending fatigue test setup designed at laboratory Soete forfull-scale fatigue tests on pipes. Following an enumeration of other types of fatigue test setups an attempt ismade to characterise the resonant bending machine. The characterisation is obtained by conductingdifferent tests on a steel pipe of grade API X65. Concordance between measured and calculated stressesand influence of excentre position on stress amplitude is discussed. High frequencies and small powerinput make this test setup very effective. The analytical model correctly predicts the measured stresses anda stress versus excentre curve is obtained. However not yet fully defined, it gives a first indication for theexcentre position when preparing for a fatigue test.
Low energy pulsing electromagnetic fields modify biomedical processes (1987)

Abstract Low‐energy, pulsed electromagnetic fields (PEMFs) have reversed therapeutically resistant pathologic processes in the musculo‐skeletal system. Their development as a non‐thermal therapeutic agent is based on 30 years of study of the electro‐biological properties of connective tissues. Specific energy characteristics in applied PEMFs produce selected biological effects by modifying synthetic and other behavioral patterns of target cells; some mechanisms of action are defined. The technology appears safe and effective in clinical treatment of un‐united fractures, avascular necrosis of bone, and chronic, refractory tendinitis. An expanding, rational use in biomedical science is predicted.
High-throughput organ-on-a-chip systems: Current status and remaining challenges (2018)

active support in the Micro Organo-Lab
Applying co-training methods to statistical parsing (2001)

We propose a novel Co-Training method for statistical parsing. The algorithm takes as input a small corpus (9695 sentences) annotated with parse trees, a dictionary of possible lexicalized structures for each word in the training set and a large pool of unlabeled text. The algorithm iteratively labels the entire data set with parse trees. Using empirical results based on parsing the Wall Street Journal corpus we show that training a statistical parser on the combined labeled and unlabeled data strongly out-performs training only on the labeled data.
Design and Optimization of FSAE Race Car suspension system (2015)

In this paper, FSAE race car is taken as the research object, dynamic performance of the suspension system is studied. 3D model of the whole vehicle suspension system is built by using 3D modeling software, and the kinematics simulation is carried out. On the basis of this, ADAMS is used for dynamic simulation, the changes of kingpin inclination angle, kingpin caster angle, camber angle, front wheel toe angle and ground point lateral slip amount of front wheel with wheel beat is analyzed, and the outer wheel angle has been optimized and designed. The results show that the designed suspension system meets the design requirements.
Suraksha: Low Cost Device to Maintain Social Distancing during CoVID-19 (2020)

On the 11th of March 2020, the World Health Organization (WHO) affirmed COVID-19, a pandemic, in response to more than 1,00,000 confirmed cases globally in more than 100 nations and the persistent danger of spreading further. Presently, there's no remedy or vaccine for COVID-19. The only way to curb its menace is taking precautionary measures, as advised by the health experts. Social distancing, that is maintaining a minimum distance of 1 to 1.5 meter between two individuals, is one of the foremost proactive measures advised by WHO. This paper presents a smart wearable device, Suraksha, that can be worn while travelling outside and will help maintain social distancing. The user will be able to rely on this device's alerting mechanism without having to constantly worry about their surroundings. It is a simple device which is easy to use and is built using basic electronic components. The device is also capable of integrating with the health applications over Bluetooth and support contact tracing.
Real-time location system-based asset tracking in the healthcare field: lessons learned from a feasibility study (2018)

The successful introduction of asset tracking systems based on real-time location in hospitals requires the selection of clear targets (e.g., users and assets) via analysis of the user environment and implementation of appropriate technical improvements in the system as required (e.g., miniaturization of the tag size and improvement of the sensing accuracy).
Insulin-like growth factor-I (somatomedin C) levels in chronic fatigue syndrome and fibromyalgia. (1996)

These findings suggest the disruption of the growth hormone-IGF-I axis previously demonstrated in FM patients is not evident in a referral population of patients with CFS, CFS-FM, or FM.
Hexagonal Boron Nitride UDMA Resin Composites (2018)

Objectives: To evaluate the potential of Hexagonal Boron Nitride as a reinforcing filler for light curable UDMA resin composites. Methods: Experimental resin composite formulated by incorporating 40 wt% hydroxyapatite into a UDMA monomer matrix with a photo-initiator system of CQ and DMAEM was used as control for the present study. Four hexagonal Boron Nitride (hBN) resin composites were fabricated by introducing 0.25 and 0.5 wt% of two hBN with difference morphology into the control. Cylindrical specimens (5 mm x 1/2 mm) were light cured and the real time transmitted irradiance at the bottom specimen surface was recorded using a calibrated spectrometer (MARC Resin Calibrator). The degree of conversion immediate and 7 d after cured (DC0 and DC7d), post-irradiance hardness (VHN0 and VHN 7d) and 7 d post-cured flexural strength were measured by a FTIR spectroscopy, a Vickers indenter and a universal testing machine respectively (n=5). Difference between the results was analysed using one way ANOVA (p<0.05) followed by Tukey`s post hoc test. Results: The presence of hBN did not change the overall shape of the irradiation curve, but resulted in a reduction in the maximum transmitted irradiance (Imax) at the bottom sample surface compared with control. Sample thickness in contract had a dramatic influence on Imax. The addition of hBN did not significantly change DC for the 1 mm specimens; however, 0.5 wt% h-BN has a detrimental influence on DC for the 2 mm specimens. Post-irradiance hardness increased after 7 d, but no significant difference was noticed between groups. The addition of hBN led to a significant increase in flexural strength compared with the control group. Conclusions: Small amount of hBN did not change the curability of experimental UDMA resin composite but led to increased flexural strengths indicating that hBN has the potentials as a reinforcing filler for dental resin composites.
More Hip Op Than Hip Hop: Temporality of the Dancing Body (2011)

I'm not bad for someone nearing 40.But I am sitting (not in a Stannah chair lift) writing this, contemplating a pair of magi-knickers (a must for any ex-practitioner of the Martha Graham technique) after overdosing on multi-vitamins.This coming of age is unwelcome, perhaps akin to the dancers' menopause: reluctantly undergoing physical and psychological changes where the aches and pains of my parents' generation now increasingly belong to me.I only need to take a look into the dance studio mirror to realise I was born naked, the rest is just Coal Tar Soap.For a dancer, nearing 40, I am considered geriatric.My mind repeats the same cutting question.If a ballet dancer would hang up their pointe shoes, at what point does the contemporary dancer wash their feet clean after a final performance?Whilst denying this invasive reality, I still have some options.I could seek a younger version of myself to dance my works.I could explore a slower moving aesthetic and gentle performative that has less impact on the joints.I could become a parody of what I used to be.I could leap out of the studio, dignity intact, whilst I still can, and become a dance maker, researcher and mentor or, I could leave dance altogether.Or I could just simply change the question.Why am I doing this and for whom?These are, I am sure, all dancers' innermost fears as they head down what seems to be a path of decay (to, in some cases, Job Centre Plus).Here lies the most poignant question of all.Do I self destruct or should I value what I have?As an undergraduate, I came into dance education at a later age than the average dancer.When I walked through the studio doors at the tender age of twenty, I was asked "what do YOU want?" to which I replied "well what have you got?"I knew very little about techniques and was already deemed too old for classical dance training by the ballet 'establishment'.Fortunately, I was given a life line in the way of a university education in dance, live art and drama.I had a natural ability which was quickly recognised and nurtured by enlightened tutors.I was lucky.But my time was limited.Dancers in later life tend to gravitate towards
Trapping choline oxidase in a nonfunctional conformation by freezing at low pH (2006)

Choline oxidase is a flavin-dependent enzyme that catalyzes the oxidation of choline to glycine-betaine, with oxygen as electron acceptor. Storage at pH 6 and -20 degrees C resulted in a change in the conformation of choline oxidase, which was associated with complete loss of catalytic activity when the enzyme was assayed at pH 6. Incubation of the inactive enzyme at pH values > or = 6.5 and 25 degrees C resulted in a fast and partial reactivation of the enzyme, which occurred with slow onset of steady state during enzymatic turnover. The rate of approaching steady state was independent of the concentrations of choline and enzyme, but increased to a limiting value with increasing pH, defining a pKa value of approximately 7.3 for an unprotonated group required for enzyme activation. Prolonged incubation of the inactive enzyme at pH 6 and temperatures > or = 20 degrees C, at which no hysteretic behavior was observed, resulted in the slow and full recovery of activity over 3 h, associated with a conformational change that reverted the enzyme to the native form. Activation of the enzyme at pH 6 was enthalpy-driven with deltaH(double dagger) and TdeltaS(double dagger) values of approximately 112 kJ mol(-1) and approximately 20 kJ mol(-1) determined at 25 degrees C. These data suggest that freezing the enzyme at low pH induces a localized and reversible conformational change that is associated with the complete and reversible loss of catalytic activity.
Harnessing knowledge for innovation: an integrated management framework (2005)

Abstract Purpose – The purpose of this article is to examine, develop and establish understanding of the management of knowledge innovation (KI). Design/methodology/approach – This article first describes the emergence of knowledge management (KM) as the next likely source of competitive advantage. It then explains why innovation management (IM) should not be viewed as mutually independent from KM, but instead should involve concepts on how to harness KM practices for executing IM processes. Next, it elaborates the definition of KI and describes the economic transition from "information revolution" to "knowledge revolution" – wherein various forms of knowledge‐based assets may be absorbed, assimilated, shared and utilised for innovation. It then turns to the role of knowledge creation and the value of knowledge capital in support of the significance of knowledge to innovation. Siemens, a highly successful company that strongly integrates KM and IM, is highlighted as an exemplar for discussion. Findings – The article proposes an integrated management framework for managing KI in relation to perspectives on knowledge‐centred principles, knowledge‐sharing infrastructures and knowledge‐based initiatives. Finally, it concludes with the future challenges for organisations to exploit better the full benefits of KI. Originality/value – The management issues raised in this article are expected to be of interest to industry planners, business executives and academic researchers.
Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns (2016)

The increased number of annotated bacterial genomes provides a vast resource for genome mining. Several bacterial natural products with epoxide groups have been identified as pre-mRNA spliceosome inhibitors and antitumor compounds through genome mining. These epoxide-containing natural products feature a common biosynthetic characteristic that cytochrome P450s (CYPs) and its patterns such as epoxidases are employed in the tailoring reactions. The tailoring enzyme patterns are essential to both biological activities and structural diversity of natural products, and can be used for enzyme pattern-based genome mining. Recent development of direct cloning, heterologous expression, manipulation of the biosynthetic pathways and the CRISPR-CAS9 system have provided molecular biology tools to turn on or pull out nascent biosynthetic gene clusters to generate a microbial natural product library. This review focuses on a library of epoxide-containing natural products and their associated CYPs, with the intention to provide strategies on diversifying the structures of CYP-catalyzed bioactive natural products. It is conceivable that a library of diversified bioactive natural products will be created by pattern-based genome mining, direct cloning and heterologous expression as well as the genomic manipulation.
An aquaporin-based vesicle-embedded polymeric membrane for low energy water filtration (2013)

Aquaporins (AQPs) are transmembrane water channel proteins that serve as nano-filters to selectively transport water molecules through plasma membranes in living cells at high speeds while blocking all other solutes from going through. It is envisioned that biomimetic membranes composed of aquaporin and amphiphilic phospholipids or copolymers may have great potential for use in high flux and low energy consumption water purification processes. However, the major barrier for using such a biomimetic membrane is that the ultrathin biomimetic bilayers are often too fragile to withstand high hydraulic or osmotic pressures in industrial water purification processes. Here, we show an innovative method to overcome membrane fragility by using these water channel proteins incorporated into vesicles and surface imprinting onto a substrate membrane. The water channel protein Aquaporin Z (AQPz) was reconstituted into self-assembled polymer vesicles and then immobilized onto a porous support membrane. In situ “surface imprinting” polymerization was then conducted to generate a dense hydrophobic polymer layer. This novel membrane was shown to have a well-controlled nano-structured selective layer that exhibits high mechanical strength and stability during the water filtration process. The water purification performance is significantly improved by using the AQPz-vesicle-imprinted membrane in either nanofiltration or forward osmosis mode.
Some characteristics of foreshocks and their possible relationship to earthquake prediction and premonitory slip on faults (1979)

Foreshocks occur before a large fraction of the world's major (M ≥ 7.0) earthquakes. Teleseismically located events before major earthquakes from 1914 to 1973 were considered together to examine possible average temporal and spatial patterns of foreshock occurrence. Several days before the main shocks and apparently near the epicenters of them (Δ ≲ 30 km) the activity begins to increase, culminating in a final rapid acceleration of activity in the last day. The acceleration continues up to the time of the main shocks, except for a possible temporary decrease about 6 hours before them. The seismicity increases approximately as the inverse of time before main shock. This relationship is essentially unrelated to the magnitude of the main shock. The magnitude of the largest foreshock is also unrelated to the magnitude of the main shock. In addition, pairs of major events are common. Ten percent of the world's major events are preceded by other major events within 100 km and 3 months. For foreshocks within each of three sequences studied, the ratio of the amplitudes of the P and S waves were approximately the same, suggesting that the faulting mechanisms are the same for events in each sequence. By assuming an inhomogeneous fault plane on which asperities fail by static fatigue, we derived an equation for accelerating premonitory slip as a function of time, which agrees with the observed time dependence of foreshocks.