gebhart/patrepeval huggingface dataset:
CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus (2006)

Recent studies suggest that the chromosome 16 inversion, associated with acute myeloid leukemia M4Eo, takes place in hematopoietic stem cells. If this is the case, it is of interest to know the effects of the resulting fusion gene, CBFB-MYH11, on other lineages. Here we studied T-cell development in mice expressing Cbfb-MYH11 and compared them with mice compound-heterozygous for a Cbfb null and a hypomorphic GFP knock-in allele (Cbfb(-/GFP)), which had severe Cbfb deficiency. We found a differentiation block at the DN1 stage of thymocyte development in Cbfb-MYH11 knock-in chimeras. In a conditional knock-in model in which Cbfb-MYH11 expression was activated by Lck-Cre, there was a 10-fold reduction in thymocyte numbers in adult thymus, resulting mainly from impaired survival of CD4+CD8+ thymocytes. Although Cbfb-MYH11 derepressed CD4 expression efficiently in reporter assays, such derepression was less pronounced in vivo. On the other hand, CD4 expression was derepressed and thymocyte development was blocked at DN1 and DN2 stages in E17.5 Cbfb(-/GFP) thymus, with a 20-fold reduction of total thymocyte numbers. Our data suggest that Cbfb-MYH11 suppressed Cbfb in several stages of T-cell development and provide a mechanism for CBFB-MYH11 association with myeloid but not lymphoid leukemia.
Segmented Coordinated Control Based on Active Steering and Differential Braking for Lane Departure Prevention (2020)

To improve the control performance of the lane departure prevention system, a segmented coordinated control method of active steering and differential braking is proposed. Taking the longitudinal velocity and road curvature as input and considering the driving habits of the driver in different lanes, the fuzzy controller used to determine the virtual lane boundary is designed. The control decision of LDPS is determined by combining the steering behavior index, which characterizes the steering intervention of the driver with the virtual lane boundary width. Next, the segmented control strategy is designed. In the first stage of the assistance control, the intervening time of coordinated control mode based on active steering and differential braking and the additional yaw moment when working in coordinated control mode is determined. A single control mode based on active steering is adopted in the second phase of assistance control. Finally, the effectiveness of the proposed coordinated control method is evaluated with numerical simulation and experiments on a human-in-the-loop platform. The obtained results show that the designed method not only can avoid lane departures effectively, but also provides a smooth ride quality to the passenger.
Wheat ATIs: Characteristics and Role in Human Disease (2021)

Amylase/trypsin-inhibitors (ATIs) comprise about 2-4% of the total wheat grain proteins and may contribute to natural defense against pests and pathogens. However, they are currently among the most widely studied wheat components because of their proposed role in adverse reactions to wheat consumption in humans. ATIs have long been known to contribute to IgE-mediated allergy (notably Bakers' asthma), but interest has increased since 2012 when they were shown to be able to trigger the innate immune system, with attention focused on their role in coeliac disease which affects about 1% of the population and, more recently, in non-coeliac wheat sensitivity which may affect up to 10% of the population. This has led to studies of their structure, inhibitory properties, genetics, control of expression, behavior during processing, effects on human adverse reactions to wheat and, most recently, strategies to modify their expression in the plant using gene editing. We therefore present an integrated account of this range of research, identifying inconsistencies, and gaps in our knowledge and identifying future research needs. <b>Note</b> This paper is the outcome of an invited international ATI expert meeting held in Amsterdam, February 3-5 2020.
Orchestrating Multiple Data-Parallel Kernels on Multiple Devices (2015)

Traditionally, programmers and software tools have focused on mapping a single data-parallel kernel onto a heterogeneous computing system consisting of multiple general-purpose processors (CPUS) and graphics processing units (GPUs). These methodologies break down as application complexity grows to contain multiple communicating data-parallel kernels. This paper introduces MKMD, an automatic system for mapping multiple kernels across multiple computing devices in a seamless manner. MKMD is a two phased approach that combines coarse grain scheduling of indivisible kernels followed by opportunistic fine-grained workgroup-level partitioning to exploit idle resources. During this process, MKMD considers kernel dependencies and the underlying systems along with the execution time model built with a few sets of profile data. With the scheduling decision, MKMD transparently manages the order of executions and data transfers for each device. On a real machine with one CPU and two different GPUs, MKMD achieves a mean speedup of 1.89x compared to the in-order execution on the fastest device for a set of applications with multiple kernels. 53% of this speedup comes from the coarse-grained scheduling and the other 47% is the result of the fine-grained partitioning.
A Convenient Synthesis of Thiopyrano[2,3-<i>e</i>]benzofuran:  A New Sulfur Analogue of Angelicin (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA Convenient Synthesis of Thiopyrano[2,3-e]benzofuran: A New Sulfur Analogue of AngelicinAndreas E. Jakobs and L. ChristiaensView Author Information Laboratory of Heterocyclic Organic Chemistry, Institute of Chemistry (B6), University of Liège, B-4000 Liège, Belgium Cite this: J. Org. Chem. 1996, 61, 14, 4842–4844Publication Date (Web):July 12, 1996Publication History Received8 February 1996Published online12 July 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo960262chttps://doi.org/10.1021/jo960262cbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views225Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Genetics,Light absorption,Molecular structure,Organic reactions,Sulfur Get e-Alerts
American journalism and the politics of diversity (2004)

Ethnic-identity professional organizations, such as Unity: Journalists of Color, Inc., have become among the most prominent journalistic voices in contemporary US newsrooms. Supported by major foundations and media companies, this diversity journalism movement has focused on two primary goals: increased employment of non-white journalists and more news attention to ‘communities of color’. While these goals have been partially achieved, the movement has paradoxically also contributed - by providing ‘progressive’ political cover to marketing-driven transformations of the media industry - to actually reducing the diversity of ideological perspectives in the news. Drawing on research on US news coverage of immigration between the 1970s and 1990s, linkages are made between the increased journalistic valorization of ethnic/racial identities, the rise of multi-cultural marketing, and a sharp decline in media attention to economic inequalities and labor perspectives.
Enhancing Promotional Strategies Within Social Marketing Programs: Use of Web 2.0 Social Media (2008)

The second generation of Internet-based applications (i.e., Web 2.0), in which users control communication, holds promise to significantly enhance promotional efforts within social marketing campaigns. Web 2.0 applications can directly engage consumers in the creative process by both producing and distributing information through collaborative writing, content sharing, social networking, social bookmarking, and syndication. Web 2.0 can also enhance the power of viral marketing by increasing the speed at which consumers share experiences and opinions with progressively larger audiences. Because of the novelty and potential effectiveness of Web 2.0, social marketers may be enticed to prematurely incorporate related applications into promotional plans. However, as strategic issues such as priority audience preferences, selection of appropriate applications, tracking and evaluation, and related costs are carefully considered, Web 2.0 will expand to allow health promotion practitioners more direct access to consumers with less dependency on traditional communication channels.
Hypermethylation of the RASSF1A tumor suppressor gene in Japanese clear cell renal cell carcinoma (2004)

Hypermethylation associated inactivation of RASSF1A tumor suppressor gene at chromosome 3p21.3 has been observed in several human malignancies. Relatively high (91%) or low (23%) frequencies were reported in the methylation status of promoter region of the RASSF1A gene in clear cell renal carcinoma (RCC) depending on the country the report was from. To clarify exact contribution of the hypermethylation of RASSF1A gene in the development of RCC in Japan, we analyzed the methylation status of the RASSF1A promoter region in 50 Japanese clear cell RCC and RCC cell lines. Although relatively high frequency of hypermethylation in RASSF1A promoter (39 of 50 tumors, 78%) was observed, most of matched proximal normal tissue DNA also showed weak methylation. By comparison with methylation level of adapted normal kidney tissue DNA, tumor preferential hypermethylation in RASSF1A promoter was recognized as 40% (20/50 matched sets) of primary clear cell RCCs. Hypermethylation in RASSF1A promoter was observed in 36% (15/42) and 64% (5/8) of stage I-II or III-IV tumors, and also observed in 42% (11/26) and 38% (9/24) of our tumor samples with pathological grade I or II, respectively. In addition, 16 of 19 RCC cell lines (84%) showed complete or partial methylation of RASSF1A promoter region. There was no association between the frequency of RASSF1A methylation and inactivation of VHL tumor suppressor gene in either primary RCCs or RCC cell lines. Our results showed tumor specific RASSF1A promoter hypermethylation in up to 40% of low grade or low stage clear cell RCCs. It is essential to compare the methylation status of RASSF1A promoter in tumor with normal tissue to understand tumor specific hypermethylation. Since considerable cases of normal kidney are hypermethylated, contribution of the RASSF1A for the development and progression of kidney cancer may be more complex than expected.
Stem infusion of field‐grown maize (1994)

Abstract Field experiments were conducted in summer 1992 on the Central Experimental Farm, Ottawa (45°22'N, 75°43'W) to determine whether a stem infusion technique developed for maize under controlled conditions was applicable to field‐grown maize and to evaluate whether providing sucrose in solution at silking via stem infusion altered plant source‐sink relationships sufficiently to increase kernel set. The higher and more variable evaporative demand and more difficult installation under field conditions dictated modifications to the stem infusion apparatus to prevent leakage and to facilitate assembly prior to field set‐up. A range of several field parameters were tested to identify conditions that would maximize infusion of sucrose solution: raising the syringe barrel height increased the volume of solution uptake; the largest amount of sucrose was taken up using a concentration of 150 g sucrose L‐1, and consecutive multiple infusions of the same plant increased solution uptake. Solution uptake was found to be greatest in the first 24 h of infusion. Leaf soluble carbohydrate and starch concentrations and ear leaf photosynthesis were not changed by sucrose infusion. Sucrose solution infused at silking appeared to increase kernel set in one of the experimental hybrids.
Treatment of sensorineural hearing loss. (1991)

Of the 25 million people who are hearing impaired, 85% suffer from sensorineural hearing loss (SNL). In the past decade, the identification and treatment of SNL have evolved from futile efforts to active intervention. This paper identifies nine forms of inner ear disorders causing SNL for which medical/surgical treatment is available. Physicians must realize that, with appropriate diagnosis and treatment, hearing nerve loss can have a satisfactory outcome.
Communication failures in patient sign-out and suggestions for improvement: a critical incident analysis (2005)

Communication failures during sign-out often lead to uncertainty in decisions on patient care. These may result in inefficient or suboptimal care leading to patient harm.
Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis (2014)

Advanced MRI techniques at 3T, unraveled the nature of brain tissue damage in early MS and substantially improved clinical-radiological correlations in patients with minor deficits, as compared to conventional measures of disease.
Semiclassical model of triple photons generation in optical fibers (2011)

In this Letter we study spontaneous generation of triple photon states in optical fibers by third order spontaneous downconversion. Using a semiclassical approach we derive an explicit expression for the triple photons generation efficiency as a function of fiber parameters. We show that optical fibers with well suited index profiles and standard outer diameters could be the key component of future triple photons sources.
Compare new designed flow channels of interconnect for planar SOFCs with typical channels (2009)

Design of advanced flow channels in bipolar plates is one of the key factors affecting SOFC stack and system performance. Various transport phenomena occurring in SOFCs with conventional interconnects, such as rib-channels, serpentine channels, etc, have been extensively studied. In this paper new designed channels have been proposed and evaluated numerically by computational software. The investigated geometry consists of two computational domains: a porous anode layer and interconnect, the latter one serves as gas distribution for hydrogen or air in SOFCs. Compared with conventional designs, the configuration of interconnect having honeycomb structures is different. Such unique channels lead to gas flow in many directions, and gas flow distribution and pressure drop are significantly different from those in previous studies. This simulation employs the Navier-Stokes equations for gas flow in channels, and the Darcy model in the porous layer. Combined gas and heat transfer in channels and the porous gas diffusion layer, permeation across the interface are analyzed by a fully threedimensional code in this paper. All the governing equations are solved utilizing the commercial code COMSOL. The velocity field, the distribution of hydrogen in channels, the fraction of the hydrogen entering the anode diffusion layer, and the pressure drop are predicted and presented. Also, the numerical predictions of the cell performance are compared with the experimental results. The numerical results and findings from this study are important for optimizing the flow fields, decreasing the cost of experiments, designing the channels. NOMENCLATURE (OPTIONAL) R e Reynolds number S source term T temperature, K i U velocity components in x, y and z directions,
Effect of knee flexion on the in situ force distribution in the human anterior cruciate ligament (1995)

This study was conducted to evaluate the effect of applied load on the magnitude, direction, and point of tibial intersection of the in situ forces of the anteromedial (AM) and posterolateral (PL) bands of the human anterior cruciate ligament (ACL) at 30 degrees and 90 degrees of knee flexion. An Instron was used to apply a 100 N anterior shear force to 11 human cadaver knees, 6 at 30 degrees of knee flexion and 5 at 90 degrees of knee flexion. A Universal Force Sensor (UFS) recorded the resultant 6 degree-of freedom (DOF) forces/moments. Each specimen then underwent serial removal of the AM and PL bands. With the knee limited to 1 DOF (anteroposterior), tests were performed before and after each structure was removed. Because the path was identical in each test, the principle of superposition was applied. Thus, the difference between the resultant forces could be attributed to the force carried by the structure just removed. The magnitudes of force in the ACL at 30 degrees and 90 degrees of knee flexion were 114.1 +/- 7.4 N and 90.8 +/- 8.3 N, respectively (P < 0.05). At 30 degrees, the AM and PL bundles carried 95% and 4% of the total ACL force, respectively. At 90 degrees, the AM and PL bands carried 85% and 13%, respectively (P < 0.05). The direction of the in situ force in the whole ACL as well as its two bands correlated with the anatomic orientation of the ligament.(ABSTRACT TRUNCATED AT 250 WORDS)
Economic Evaluation of Ticagrelor in Treating Patients with Acute Coronary Syndrome in Hong Kong: A Cost-Utility Analysis (2020)

This study aimed to evaluate the long-term cost-effectiveness of ticagrelor plus aspirin versus generic clopidogrel plus aspirin in acute coronary syndrome patients in Hong Kong (HK) from a public hospital’s perspective. The study has adapted a previously developed two-component prediction model. The first component is a simple decision tree corresponding to the first year. Afterwards events in the second year onwards were estimated using a state-transition Markov model incorporating the potential of recurrent events such as myocardial infarction and strokes that could lead to death for estimating the long-term economic and health outcomes measured as cost per quality-adjusted life year (QALYs). Kaplan Meier survival analysis was employed to determine the risk of events. Probabilistic sensitivity analysis was used to estimate the probability of ticagrelor being cost-effective. A cost-effectiveness acceptability curve was used to estimate the willingness-to-pay of patients. The use of ticagrelor led to improved clinical outcomes by gaining additional life-years and QALYS over 5-year and lifetime time horizons. The incremental cost-effectiveness ratio was above 1 Gross Domestic Product (GDP) per capita only for the 1-year results. By replacing clopidogrel with ticagrelor for life-time, the incremental drug costs were offset by the substantial reduction in other direct costs, leading to an overall cost-savings of HK 2,878 per patient. The probabilistic sensitivity analysis showed that ticagrelor has 53.5% chance of being dominant and 34.7% being cost-effective at a threshold of 1 GDP per capita for Hong Kong. A cost-effectiveness acceptability curve also showed that the willingness-to-pay for ticagrelor was 90% at 1 GDP per capita. Ticagrelor plus aspirin appeared to be cost-effective over 5-year and life-time projection periods compared to clopidogrel plus aspirin.
Application of multiple genetic algorithm processor in complex systems (2002)

We describe the application of a hardware genetic algorithm processor to handle the adaptive IIR filter problem. We have analysed a variety of configurations including varying the string word length and the introduction of multiple processor configurations. Results show that multiple genetic algorithm processor configurations work better than other configurations with lesser complexity. It is possible to apply multiple configurations to more complex problems.
Elevated Concentrations of Interleukins and Leukotriene in Response to <i>Mycobacterium Tuberculosis</i> Infection (1997)

There is significant research in the role of interleukins in lung disease, as the cytokines are important mediators in the host response to mycobacterium tuberculosis infection. Plasma from patients with pulmonary tuberculosis (TB) and healthy controls were investigated for their content of granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-6 (IL-6) and leukotriene B4 (LTB4). LTB4 and IL-6 were measured by enzyme immunoassay after lipid extraction in the case of LTB4 while GM-CSF was measured by enzyme amplified sensitive immunoassay. Significantly elevated concentrations of IL-6 were found in far-advanced lesions of pulmonary tuberculosis patients, P < 0.05. However, nonsignificant increases of IL-6 were obtained in moderate lesions and minimal lesions compared to normal healthy subjects. Marked elevations of LTB4 were found in TB patients, the highest values being shown in patients with far-advanced lesions followed by moderately advanced and minimal lesions in relation to the mean value for normal healthy controls, P < 0.001 for all groups. 93% of the tuberculosis patients showed a higher level of LTB4 above the upper limit of the control group. In contrast there was no significant increase of GM-CSF in any of the TB subgroups. These results suggest that LTB4 and the interleukins may play a role in the pathogenesis of mycobacterium tuberculosis infection.
Assignment of games to servers in the OnLive cloud game system (2014)

OnLive is a thin-client, cloud-based, video game streaming service. As part of their service, OnLive must distribute game content to their servers in a manner that provides good performance for the players while using hardware resources effectively. In order to evaluate and improve the effectiveness of their game distribution strategies, we built a simulator for OnLive's service and modeled their current game distribution strategy. Using a hill-climbing algorithm, we constructed game distribution strategies with improved abilities to meet customer demand while significantly reducing disk space requirements.
A quantum macro assembler (2016)

We present a low-level software building block intended to be used to implement higher-level programming models atop quantum annealers such as the D-Wave 2X™. By analogy to a macro assembler for conventional architectures, our quantum macro assembler enables a programmer to express computations symbolically and without regard to the specifics of the underlying hardware. We demonstrate that the quantum macro assembler can be useful in its own right as a programming interface despite providing only a minimal level of hardware abstraction.
Ebola Virus VP40 Drives the Formation of Virus-Like Filamentous Particles Along with GP (2002)

Using biochemical assays, it has been demonstrated that expression of Ebola virus VP40 alone in mammalian cells induced production of particles with a density similar to that of virions. To determine the morphological properties of these particles, cells expressing VP40 and the particles released from the cells were examined by electron microscopy. VP40 induced budding from the plasma membrane of filamentous particles, which differed in length but had uniform diameters of approximately 65 nm. When the Ebola virus glycoprotein (GP) responsible for receptor binding and membrane fusion was expressed in cells, we found pleomorphic particles budding from the plasma membrane. By contrast, when GP was coexpressed with VP40, GP was found on the filamentous particles induced by VP40. These results demonstrated the central role of VP40 in formation of the filamentous structure of Ebola virions and may suggest an interaction between VP40 and GP in morphogenesis.