gebhart/patrepeval huggingface dataset:
Role Of Long Pentraxin 3 (PTX3) In Wound Closure Induced By Bone Marrow-Derived Mesenchymal Stromal Cells (2013)

Abstract Although several studies have shown the capacity of mesenchymal stromal cells (MSCs) to repair and regenerate different tissues, the mechanisms underlying these processes are not understood. Long Pentraxin 3 (PTX3) is a multifunctional protein produced by MSCs and other cell subsets upon activation with inflammatory cytokines. PTX3 is involved in innate immunity, inflammation and extracellular matrix deposition. In the present study we analyzed the potential role of PTX3 in wound repair process induced by MSCs. PTX3 knockout MSCs (PTX3-/-MSCs) were collected from bone marrow of PTX3-/- mice. After 3-5 culture passages the expression of surface markers was analyzed by flow cytometry and their osteogenic and adipogenic differentiation capacity was detected by alizarin red O and oil red S staining, respectively. The ability of PTX3-/-MSCs to abrogate T cell proliferation was evaluated by co-culturing MSCs and PBMCs previously activated with Phytohaemagglutinin. Finally, equal number of both PTX3-/-MSCs and wild type (WT) MSCs were implanted into excisional wounds created by a biopsy punch on the back of allogenic WT and PTX3-/- mice. Wound area was measured up to 14 day and calculated using an image analysis program. The wound specimens were collected at 2, 7 and 14 days and processed for histological analysis. We demonstrated that PTX3-/-MSCs, similarly to WT MSCs, displayed typical fibroblastoid morphology, they expressed common MSC markers and were able to differentiate into adipocytes and osteoblasts. In addition, they drastically decreased the mitogen-induced proliferation of lymphocyte. Importantly, in a mouse model of wound healing, PTX3-/- MSCs showed a highly significant defect in wound closure compared to WT MSCs at each time point. Histological evaluation of skin samples treated with PTX3-/- MSCs showed a reduction of the granulation tissue and a significant increase of neutrophils (GR-1+) in the wound bed. Moreover, wounds treated with PTX3-/- MSCs were characterized by an excessive accumulation of fibrin at the 2nd day after injury. Accordingly, PTX3-/- MSCs showed a defective ability to degrade the fibrin matrix in vitro. Finally, PTX3-/- MSCs failed to close the ulcers in PTX3-/- mice. In conclusion, we demonstrated that PTX3 deficiency does not alter the phenotype and the capacity of MSCs to differentiate into mesengetic lineages; however, the production of PTX3 represents an essential requirement for MSC ability of enhancing tissue repair. Disclosures: No relevant conflicts of interest to declare.
Handover protocols between metropolitan area networks (2003)

Inter-MAN handover protocols for the cellular packet switch are developed, based on interconnecting MANs via gateways. Inter-MAN handover protocols utilize the gateway to maintain a connection as a user moves across MAN boundaries. This greatly reduces the fixed-network signalling traffic while protecting information in data communications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Real time monitoring of drug action on<i>T. cruzi</i>parasites using a biospeckle laser method (2016)

In this paper, we report on a biospeckle laser method used to monitor a specific drug action on T. cruzi parasites. Experimental results from fast biospeckle monitoring of the parasites' activity under the influence of the drug demonstrate the effectiveness of the proposed method. We measure the speckle parameters such as spatiotemporal correlation and speckle grain size to assess the immediate action of the drug on the parasites during a very short incubation period. From a practical point of view, this aproach allows us to validate biospeckle as a fast, non-invasive and alternative method to test candidate drugs on T. cruzi parasites.
A direct synthesis of [(tert-butoxycarbonyl)methylidene]azacycloalkanes (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA direct synthesis of [(tert-butoxycarbonyl)methylidene]azacycloalkanesMasahiko Yamaguchi and Ichiro HiraoCite this: J. Org. Chem. 1985, 50, 11, 1975–1977Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 May 1985https://pubs.acs.org/doi/10.1021/jo00211a038https://doi.org/10.1021/jo00211a038research-articleACS PublicationsRequest reuse permissionsArticle Views271Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intermolecular ion pairs maintain the toroidal structure of <i>Pyrococcus furiosus</i> PCNA (2003)

Two mutant proliferating cell nuclear antigens from the hyperthermophilic archaeon Pyrococcus furiosus, PfuPCNA(D143A) and PfuPCNA(D143A/D147A), were prepared by site-specific mutagenesis. The results from gel filtration showed that mutations at D143 and D147 drastically affect the stability of the trimeric structure of PfuPCNA. The PfuPCNA(D143A) still retained the activity to stimulate the DNA polymerase reaction, but PfuPCNA(D143A/D147A) lost the activity. Crystal structures of the mutant PfuPCNAs were determined. Although the wild-type PCNA forms a toroidal trimer with intermolecular hydrogen bonds between the N- and C-terminal domains, the mutant PfuPCNAs exist as V-shaped dimers through intermolecular hydrogen bonds between the two C-terminal domains in the crystal. Because the mutated residues are involved in the intermolecular ion pairs through their side chains in the wild-type PfuPCNA, these ion pairs seem to play a key role in maintaining the toroidal structure of the PfuPCNA trimer. The comparison of the crystal structures revealed intriguing conformational flexibility of each domain in the PfuPCNA subunit. This structural versatility of PCNA may be involved in the mechanisms for ring opening and closing.
Electrospun Fibers for Drug Delivery after Spinal Cord Injury and the Effects of Drug Incorporation on Fiber Properties (2016)

There is currently no cure for individuals with spinal cord injury (SCI). While many promising approaches are being tested in clinical trials, the complexity of SCI limits several of these approaches from aiding complete functional recovery. Several different categories of biomaterials are investigated for their ability to guide axonal regeneration, to deliver proteins or small molecules locally, or to improve the viability of transplanted stem cells. The purpose of this study is to provide a brief overview of SCI, present the different categories of biomaterial scaffolds that direct and guide axonal regeneration, and then focus specifically on electrospun fiber guidance scaffolds. Much like other polymer guidance approaches, electrospun fibers can retain and deliver therapeutic drugs. The experimental section presents new data showing the incorporation of two therapeutic drugs into electrospun poly-L-lactic acid fibers. Two different concentrations of either riluzole or neurotrophin-3 were loaded into the electrospun fibers to examine the effect of drug concentration on the physical characteristics of the fibers (fiber alignment and fiber diameter). Overall, the drugs were successfully incorporated into the fibers and the release was related to the loading concentration. The fiber diameter decreased with the inclusion of the drug, and the decreased diameter was correlated with a decrease in fiber alignment. Subsequently, the study includes considerations for successful incorporation of a therapeutic drug without changing the physical properties of the fibers.
Automatic lane-level map generation for advanced driver assistance systems using low-cost sensors (2014)

Lane-level digital maps can simplify driving tasks for robotic cars as well as enhance performance and reliability for advanced driver assistance systems (ADAS) by providing strong priors about the driving environment. In this paper, we present a system for automatic generation of precise lane-level maps by using conventional low-cost sensors installed in most of current commercial cars. It mainly consists of two modules, i.e. road orthographic image generation and lane graph construction. First, we divide the global map into fixed local segments based on the road network topology. According to the local map segments, we accumulate the bird's eye view images of the road surface by fusing GPS, INS and visual odometry, and subsequently integrate them into synthetic orthographic images with the reference of the local map segments. Furthermore, the information of the driving lanes is extracted from the orthographic images and a large amount of vehicle trajectories, which is used to construct the lane graph of the map based on the lane models we proposed. Such a system can offer increased value as well as promote the automation level for today's commercial cars without being supplemented additional sensors. Experiments show promising results of the automatic map generation of the real-world roads, which substantiated the effectiveness of the proposed approach.
From Complex Natural Products to Simple Synthetic Mimetics by Computational De Novo Design (2016)

We present the computational de novo design of synthetically accessible chemical entities that mimic the complex sesquiterpene natural product (-)-Englerin A. We synthesized lead-like probes from commercially available building blocks and profiled them for activity against a computationally predicted panel of macromolecular targets. Both the design template (-)-Englerin A and its low-molecular weight mimetics presented nanomolar binding affinities and antagonized the transient receptor potential calcium channel TRPM8 in a cell-based assay, without showing target promiscuity or frequent-hitter properties. This proof-of-concept study outlines an expeditious solution to obtaining natural-product-inspired chemical matter with desirable properties.
Space-sharing AR interaction on multiple mobile devices with a depth camera (2016)

In this paper, we propose a markerless augmented reality (AR) system that works on multiple mobile devices. The relative positions and orientations of the devices and their individual motions are estimated from 3D information in real space obtained by depth cameras attached to the devices. The system allows multiple users to share the AR space and to interact with the same virtual object. To estimate the relative positions and orientations of the devices, the system generates 2D images by looking down from above at the 3D scene obtained by the depth cameras, performs 2D registration using template matching, and obtains a transformation matrix that transforms the coordinate system of one camera to that of another camera. The motion of a camera is estimated using the ICP algorithm to realize markerless AR. Using the proposed system, we created an application that enables multiple users to interact with the same virtual object.
Avaliação das propriedades físico-mecânicas de uma massa cerâmica para revestimento poroso (BIII) (2005)

O presente trabalho teve por objetivo estudar as propriedades físico-mecânicas de uma massa para revestimento cerâmico poroso base vermelha a partir de matérias-primas da região Norte Fluminense. A massa cerâmica preparada pelo processo via seca foi caracterizada quanto a composição química, análise de tamanho de partícula, difração de raios X e comportamento térmico. Os corpos cerâmicos foram prensados sob 35 MPa e sinterizados entre 1080 e 1200 ºC usando um ciclo de queima rápido. A microestrutura sinterizada foi avaliada por microscopia eletrônica de varredura. Os corpos cerâmicos sinterizados exibiram baixos valores de retração linear, resultando em boa estabilidade dimensional. A microestrutura é caracterizada por alta porosidade. Além disso, foram atingidas as especificações para revestimento poroso (NBR 13818) em termos da tensão de ruptura à flexão e da absorção de água dos corpos cerâmicos sinterizados, indicando o potencial das matérias-primas cerâmicas do Norte Fluminense para este tipo de aplicação.
A carrier frequency synchronization method for device-to-device communication network (2013)

Device-to-device (D2D) communication has received considerable attention in recent years as one of the key technologies for future communication system. Among the typical D2D communication systems, FlashLinQ (FLQ) adopted single-tone orthogonal frequency division multiplexing (OFDM) transmission which enables wide-sense discovery by time domain spreading and very low peak to average power ratio (PAPR). Although synchronization based on a common external source (CES) is basically assumed in FLQ, a means to support devices when they are unable to use a CES is still necessary. In OFDM system, generally, carrier frequency offset (CFO) induces inter-carrier interference (ICI) which degrades overall system performance drastically. Especially in D2D system, ICI can be amplified due to not only different frequency selectivity but also different path losses between links. Accordingly, a precise estimation and compensation of CFO are very important. Therefore, in this paper, we propose a new CFO estimation method for OFDM based D2D system. In the proposed method, the estimation of CFO is obtained by using two correlation results in a symbol. The estimation procedure of the proposed method enables the independent estimation of CFO between links and the estimation range can be adaptively defined depending on the distance between the two windows. By numerical analysis and performance evaluation, we verified that the proposed method achieves precise estimation performance compared to the conventional method.
Islamophobia & Its Social Impact on Muslim World An Analytical Study (2020)

Since many decades the account of intrigues, animosity and resentment against Islam and Muslims has been subsisting and perpetual. Anti- Muslim prejudice, bigotry, discrimination and social bias have become persistent problem rather escalating day by day on the base of their religion Islam which is viewed as an implacable and Archetypal Enemy for the West. Islamophobia has increased the level of this hatred and hostility against Muslim world. Thus, devil of Islamophobia has seized brazenly whole world in general and Muslim world in particular. Muslims have been increasing level of repression, verbal abuse, physical attacks, violent assaults, vandalizing, and exclusions from all economical, civic and social wings of life in most of the western countries. These Islamophobic countries are setting a trap to eject and exclude the Muslims from Islamic civilization by diffusing different inventions on one hand, while on the other hand these western nations are trying to abnegate, disown and demolish the foundation of Muslim Societies by strengthening Zionist means of transmission which are projecting and presenting the Muslim World as fanatic, fundamentalist, orthodox, primitive, savage and OTHER. By using the tool of Islamophobia, they are trying to hollow those social foundations of Muslims world which were laid by the Holy Prophet PBUH. Henceforth Muslim World is being entangled by the Western tricks of modernism, individualism, capitalism, racism, nationalism and materialism, which are putting havoc and drastic impacts on social life of Muslim Ummah. In this research paper it would be thrown light that how Muslims are being persecuted, discriminated and marginalized socially in the West, how they are being pushed in the bog of those inflated situations which are depicting Muslim Ummah as monolithic, terrorist, and great threat for western civilization? However, this research paper would also put forth some recommendations and suggestions for eliminating all dark veils of prejudices, resentments and negative stereotyping against Islam and Muslims.
A Novel Dispersion Monitoring Technique Based on Four-Wave Mixing in Optical Fiber (2004)

We propose a novel dispersion monitoring method based on four-wave mixing (FWM) or parametric amplification effect in optical fiber. The signal pulse stream, which is used as a parametric pump, is mixed with a weak continuous wave light at a different wavelength in a fiber. Due to the FWM effect, a so-called idler light is created at a wavelength symmetric in respect to the pump. The output idler power can be measured and is dependent on the pulsewidth and, therefore, accumulated residual dispersion of the input signal. The concept was successfully demonstrated with 40-Gb/s return-to-zero signal. This approach potentially works for data rates up to terabits per second and can be applied to provide a feedback for automatic dispersion compensation.
High-peak-power and tunable terahertz-wave generation and sensitive detection by using nonlinear parametric conversion (2012)

We report on the development of a high-peak-power, single-longitudinal-mode and tunable terahertz-wave parametric generation and detection using frequency conversion in a nonlinear MgO:LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> crystal at room temperature. The small footprint size is suitable for a variety of applications.
Role of co-repressors in transcriptional repression mediated by the t(8;21), t(16;21), t(12;21), and inv(16) fusion proteins (2001)

The t(8;21), t(16;21), inv(16), and t(12;21) are some of the most frequent chromosomal translocations found in acute myeloid and acute lymphoblastic leukemia. The fusion proteins created by these chromosomal translocations are transcriptional repressors. A full understanding of the types of proteins that these fusion proteins recruit to repress transcription will not only clarify understanding of the molecular mechanism of action of these fusion proteins but also provide further targets for therapeutic intervention.
Luminescent Platinum(<scp>II</scp>) Terpyridyl Complexes: Effect of Counter Ions on Solvent‐Induced Aggregation and Color Changes (2005)

A series of platinum(II) terpyridyl complexes [Pt(tpy)(C triple bond C-C triple bond CH)]X, 1-X (X=OTf-; PF6-; ClO4-; BF4-; BPh4-); [Pt(tpy)(C triple bond CC6H5)]X, 2-X (X=OTf-; PF6-; ClO4-; BF4-); [Pt(tpy)(C triple bond CC6H4OCH3-4)]OTf, 3-OTf, and [Pt(4'-CH3O-tpy)(C triple bond CC6H5)]OTf, 4-OTf (tpy=2,2':6',2''-terpyridine, OTf=trifluoromethanesulfonate) were synthesized and their photophysical properties determined. Electronic absorption and emission studies showed the formation of a new band upon increasing the diethyl ether content in an acetonitrile/diethyl ether mixture. This was ascribed to the formation of complex aggregates, the solution color of which is dependent on the nature of the anions. This indicates that counter ions play an important role in governing the degree of aggregation and the extent of interactions within these aggregates. Addition of various anions to solutions of 1-OTf and 1-PF6 produced anion-induced color changes upon solvent-induced aggregation, indicating that these complexes may serve as potential colorimetric anion probes.
Modelling a socialised chatbot using trust development in children: lessons learnt from Tay (2021)

Abstract In 2016 Microsoft released Tay.ai to the Twittersphere, a conversational chatbot that was intended to act like a millennial girl. However, they ended up taking Tay's account down in less than 24 h because Tay had learnt to tweet racist and sexist statements from its online interactions. Taking inspiration from the theory of morality as cooperation, and the place of trust in the developmental psychology of socialisation, we offer a multidisciplinary and pragmatic approach to build on the lessons learnt from Tay's experiences, to create a chatbot that is more selective in its learning, and thus resistant to becoming immoral the way Tay did.
The Classification of Poaceae: Subfamilies and Supertribes (1985)

A comprehensive world classification of the Poaceae is presented in which 720 currently accepted genera are distributed among five subfamilies (Pooideae, Bambusoideae, Arundinoideae, Chloridoideae, Panicoideae) and six supertribes (Triticanae and Poanae, in Pooideae; Bambusanae and Oryzanae, in Bambusoideae; Panicanae and Andropogonanae, in Panicoideae). Synonyms in recent use are listed under appropriate groups. The classification reflects a variety of numerical analyses of generic descriptions, accounting for original observations and compiled data on nearly 300 characters concerning mainly morphology, anatomy, physiology and cytology. The detailed group descriptions are fully comparative, and include statistical information on character state distributions.
Targeting Interleukin (IL) 5 for Asthma and Hypereosinophilic Diseases (2010)

Although glucocorticosteroids are still the first line of treatment for chronic asthma, over the last two decades great advances have been made in understanding the pathogenesis of asthma that enabled the identification of new therapeutic targets for asthma treatment. The interleukin (IL) 5: eosinophil axis is a hallmark pathway of allergic inflammation that has received much attention. Indeed, IL-5 is known to regulate eosinophil differentiation, proliferation, priming and activation. Therefore, therapeutic agents targeting IL-5 have been generated. In this review we will discuss the effects of IL-5 on eosinophils and outline the signaling mechanism involved in IL-5-mediated effects. Furthermore, recent results from clinical trials targeting IL-5 in asthma and hypereosinophilic syndrome will be discussed and an overview of newly developed patents aimed to target IL-5 will be reviewed.
Bridgehead Imine Substituted Cyclopentadithiophene Derivatives: An Effective Strategy for Band Gap Control in Donor–Acceptor Polymers (2013)

Bridgehead imine substituted cyclopentadithiophene structural units offer the opportunity to modify the electronic properties, in particular, the HOMO–LUMO energy levels of donor–acceptor polymers with unprecedented precision. Utilizing a common synthetic pathway, copolymers with high average molecular weights, a variety of functionality, and properties suitable for solar cell incorporation can be generated. The fabrication of organic photovoltaic devices with these new materials is demonstrated.
Biofunctionalization of Fluorescent Nanoparticles (2007)

Abstract The sections in this article are Introduction Fluorescent Nanoparticle Probes Dye‐doped Nanoparticles Quantum Dots ( QDs ) Metal Nanoparticles Hybrid Architectures Involving Fluorescent Nanoprobes Metal–Dye Dye‐doped Silica Shells Quantum Dot‐containing Microspheres Bioconjugation of Fluorescent Nanoparticles General Considerations Overview Common Coupling Reactions Bioconjugation of Polymeric Nanoparticles Noncovalent Approaches Covalent Approaches Bioconjugation of Quantum Dots Noncovalent Approaches Covalent Approaches Bioconjugation of Metallic Nanoprobes Noncovalent Approaches Covalent Approaches Design of Biocompatible Coatings General Considerations Overview Colloidal Stability Biocompatible Surfaces Cytotoxicity Nanoparticle‐stabilizing Coatings Low Cytotoxicity Coatings Applications Biosensing Polymeric Sensors Quantum Dot Sensors Metallic Sensors Fluorescent Nanoparticles as Labels in Biological Imaging Dye‐doped Nanoparticles Quantum Dots