gebhart/patrepeval huggingface dataset:
Increased megakaryopoiesis in cultures of CD34‐enriched cord blood cells maintained at 39°C (2004)

Based on previous evidence suggesting positive effects of fever on in vivo hematopoiesis, we tested the effect of hyperthermia on megakaryopoiesis (MK) in ex vivo cultures of CD34-enriched cord blood (CB) cells. The cells were cultured at 37 degrees C or 39 degrees C for 14 days in cytokine conditions optimized for megakaryocyte development and analyzed periodically. Compared to 37 degrees C, the cultures maintained at 39 degrees C produced significantly more (up to 10-fold) total cells, myeloid and MK progenitors, and total MKs, and showed accelerated and enhanced MK maturation with increased yields of proplatelets and platelets. This observation could facilitate clinical applications requiring ex vivo expansion of hematopoietic cells.
Antiviral Activity of a Selective Ribonucleotide Reductase Inhibitor against Acyclovir-Resistant Herpes Simplex Virus Type 1 In Vivo (1998)

The present study reports the activity of BILD 1633 SE against acyclovir (ACV)-resistant herpes simplex virus (HSV) infections in athymic nude (nu/nu) mice. BILD 1633 SE is a novel peptidomimetic inhibitor of HSV ribonucleotide reductase (RR). In vitro, it is more potent than ACV against several strains of wild-type as well as ACV-resistant HSV mutants. Its in vivo activity was tested against cutaneous viral infections in athymic nude mice infected with the ACV-resistant isolates HSV type 1 (HSV-1) dlsptk and PAAr5, which contain mutations in the viral thymidine kinase gene and the polymerase gene, respectively. Following cutaneous infection of athymic nude mice, both HSV-1 dlsptk and PAAr5 induced significant, reproducible, and persistent cutaneous lesions that lasted for more than 2 weeks. A 10-day treatment regimen with ACV given topically four times a day as a 5% cream or orally at up to 5 mg/ml in drinking water was partially effective against HSV-1 PAAr5 infection with a reduction of the area under the concentration-time curve (AUC) of 34 to 48%. The effects of ACV against HSV-1 dlsptk infection were not significant when it was administered topically and were only marginal when it was given in drinking water. Treatment under identical conditions with 5% topical BILD 1633 SE significantly reduced the cutaneous lesions caused by both HSV-1 dlsptk and PAAr5 infections. The effect of BILD 1633 SE against HSV-1 PAAr5 infections was more prominent and was inoculum and dose dependent, with AUC reductions of 96 and 67% against infections with 10(6) and 10(7) PFU per inoculation site, respectively. BILD 1633 SE also significantly decreased the lesions caused by HSV-1 dlsptk infection (28 to 51% AUC reduction). Combination therapy with topical BILD 1633 SE (5%) and ACV in drinking water (5 mg/ml) produced an antiviral effect against HSV-1 dlsptk and PAAr5 infections that was more than the sum of the effects of both drugs. This is the first report that a selective HSV RR subunit association inhibitor can be effective against ACV-resistant HSV infections in vivo.
Doubling acousto-optic deflector resolution utilizing second-order birefringent diffraction (1975)

We have demonstrated operation of birefringent phase-matched TeO2 deflectors, utilizing the second optical diffraction order, which maintain high diffraction efficiency with doubled resolution. 1200-spot resolution was achieved with 25-μsec access time.
Polarization correlation signal processing: Determination of the complete stokes vector (2004)

The polarization of a signal represents an additional degree of freedom in the collection of discrimination techniques available to radar and communications engineers. Use of waveforms polarized in a certain way that are optimized for discrimination of a given target represent an unexploited capability in signal processing. In this paper we describe two methods of discrimination based on polarization. The first is based on an optical technique called channeled polarimetry and makes use of optical components to generate a spectrum of polarization for a return signal. The Stokes parameters are then determined by calculating the Fourier transform of this spectrum followed by calculating the Fourier transform of the individual peaks of the spectrum. The second method uses the same optical elements but effects discrimination by comparing the polarization spectrum to those of known targets in a correlator. Both of these methods are discussed in detail and some sample calculations are presented.
Porphyrazine Binaries:  Synthesis, Characterization, and Spectroscopy of a Metal-Linked Trinuclear Porphyrazine Dimer (1997)

We have linked two porphyrazinedithiolates of the type Ni[pz((S-)2:R6)] (R = 4-tert-butylphenyl) by mutual chelation of a nickel ion. The trinuclear metal-linked porphyrazine dimer 9 is a monoanion, and it exhibits the classical EPR signal of Ni(III) bis(dithiolene) complexes. The absorption spectrum of the Ni(III)-linked dimer complex suggests that delocalization between the porphyrazine rings and the bridging [NiS4]- unit is significant.
The development of an improved model trap for monitoring <i>Ephestia cautella</i> (1992)

Abstract Delta, Covered funnel and Uni‐traps containing pheromone used for monitoring male Ephestia cautella (Walker) (Lepidoptera: Phycitidae) moths were compared in a wind tunnel in moving and still air. The shape and design of the traps and the form of pheromone plume emitted from them determined the moth's latency time, numbers orientating, alighting on the traps and captured. To improve trap design, the visual responses of the moths to rectangles of different colours and sizes and to brown and white stripes, showed that more moths were attracted to darker coloured 6 × 50 cm vertical rectangles on a white background and to 7.5 mm brown and white stripes. A cylindrical trap containing pheromone incorporating these features captured 90% and 80% of the moths released in the wind tunnel in moving and still air respectively, compared with 70% and 35% for the best commercial traps.
CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms (2007)

Overexpression of CKS1B, a gene mapping within a minimally amplified region between 153 to 154 Mb of chromosome 1q21, is linked to a poor prognosis in multiple myeloma (MM). CKS1B binds to and activates cyclin-dependent kinases and also interacts with SKP2 to promote the ubiquitination and proteasomal degradation of p27(Kip1). Overexpression of CKS1B or SKP2 contributes to increased p27(Kip1) turnover, cell proliferation, and a poor prognosis in many tumor types. Using 4 MM cell lines harboring MAF-, FGFR3/MMSET-, or CCND1-activating translocations, we show that lentiviral delivery of shRNA directed against CKS1B resulted in ablation of CKS1B mRNA and protein with concomitant stabilization of p27(Kip1), cell cycle arrest, and apoptosis. Although shRNA-mediated knockdown of SKP2 and forced expression of a nondegradable form of p27(Kip1) (p27(T187A)) led to cell cycle arrest, apoptosis was modest. Of importance, while knockdown of SKP2 or overexpression of p27(T187A) induced cell cycle arrest in KMS28PE, an MM cell line with biallelic deletion of CDKN1B/p27(Kip1), CKS1B ablation induced strong apoptosis. These data suggest that CKS1B influences myeloma cell growth and survival through SKP2- and p27(Kip1)-dependent and -independent mechanisms and that therapeutic strategies aimed at abolishing CKS1B function may hold promise for the treatment of high-risk disease for which effective therapies are currently lacking.
Tailored bimodal ultra‐high molecular weight polyethylene particles Part A Polymer chemistry (2018)

A single molecular catalyst system supported on MgCl₂ has been developed and combined with a simple two‐stage fed‐batch polymerization process to produce tailored bimodal polyethylene reactor blend particles of UHMWPE. By varying and controlling the process conditions in the first stage and second stage, bimodal HMWPE:UHMWPE reactor particles are obtained with independent control over the individual molar masses, the mass ratio of the HMWPE and UHMWPE components, and the reactor powder particle size. This allows multidimensional control over the individual UHMWPE reactor particle properties. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 1645–1656
Microstructural control of diamond thin films by microlithographic patterning (1990)

Microlithographic patterning has been used to elucidate the mechanisms controlling diamond film nucleation and grain growth. The approach is capable of establishing a degree of control over diamond nucleation on the substrate, which can be used to improve film uniformity and enhance fine grained microstructure. The observed microstructures in the patterned films are consistent with an intrinsic growth mechanism based upon defect-initiated renucleation.
A new X-ray scintillator for digital radiography (2003)

The authors report a new scintillator based on a transparent ceramic of Lu/sub 2/O/sub 3/:Eu. The material has an extremely high density of 9.4 g/cm/sup 3/ and a light output comparable to CsI:Tl. Its narrow-band emission at 610 nm perfectly matches the spectral response of charge coupled devices (CCDs). To enhance the spatial and contrast resolution, the authors have developed a special process to pixelate the scintillator and prevent the spread of light within the scintillator volume. The imaging performance of this pixelated device was evaluated using a thermoelectrically cooled CCD camera. The new scintillator is expected to play a major role in digital radiographic systems when readout technologies capable of taking advantage of the transparency are developed further.
Layer Structure Preservation during Swelling, Pillaring, and Exfoliation of a Zeolite Precursor (2008)

MCM-22(P), the precursor to zeolite MCM-22, consists of stacks of layers that can be swollen and exfoliated to produce catalytically active materials. However, the current swelling procedures result in significant degradation of crystal morphology along with partial loss of crystallinity and dissolution of the crystalline phase. Fabrication of polymer nanocomposites and coatings with MCM-22 for separation, barrier, and other applications requires a swelling method that does not alter drastically the crystal morphology and layer structure and preserves the high aspect ratio of the layers. Here, we demonstrate such a method by swelling MCM-22(P) at room temperature. The low-temperature process does not disrupt the framework connectivity present in the parent MCM-22(P) material. By extensive washing with water, the swollen material, MCM-22(PS-RT), evolves to a new ordered layered structure. Interestingly, the swelling procedure is reversible and the swollen material can be restored back to MCM-22(P) by acidification of the sample. The swollen material can also be pillared to produce an MCM-36 analogue. It can also be exfoliated, and layers can be incorporated in a polymer matrix to make nanocomposites.
Anisotropic, non-uniform misfit strain in a thin film bonded on a plate substrate (2008)

Current methodologies used for the inference of thin film stresses through curvature measurements are strictly restricted to stress and curvature states which are assumed to remain uniform over the entire film/substrate system. These methodologies have recently been extended to non-uniform stress and curvature states for the thin film subject to non-uniform, isotropic misfit strains. In this paper we study the same thin film/substrate system but subject to non-uniform, anisotropic misfit strains. The film stresses and system curvatures are both obtained in terms of the non-uniform, anisotropic misfit strains. For arbitrarily non-uniform, anisotropic misfit strains, it is shown that a direct relation between film stresses and system curvatures cannot be established. However, such a relation exists for uniform or linear anisotropic misfit strains, or for the average film stresses and average system curvatures when the anisotropic misfit strains are arbitrarily non-uniform.
Universal Glucose-based Low-molecular-weight Gelators for Both Organic and Aqueous Solvents (2019)

Herein we report the one-step syntheses of three novel sugar-based low-molecular-weight gelators (LMWGs) consisting of hydrocarbon chains and glucose units. These synthesized glucose derivatives fu...
Robust Learning-Based Parsing and Annotation of Medical Radiographs (2010)

In this paper, we propose a learning-based algorithm for automatic medical image annotation based on robust aggregation of learned local appearance cues, achieving high accuracy and robustness against severe diseases, imaging artifacts, occlusion, or missing data. The algorithm starts with a number of landmark detectors to collect local appearance cues throughout the image, which are subsequently verified by a group of learned sparse spatial configuration models. In most cases, a decision could already be made at this stage by simply aggregating the verified detections. For the remaining cases, an additional global appearance filtering step is employed to provide complementary information to make the final decision. This approach is evaluated on a large-scale chest radiograph view identification task, demonstrating a very high accuracy ( >; 99.9%) for a posteroanterior/anteroposterior (PA-AP) and lateral view position identification task, compared with the recently reported large-scale result of only 98.2% (Luo, , 2006). Our approach also achieved the best accuracies for a three-class and a multiclass radiograph annotation task, when compared with other state of the art algorithms. Our algorithm was used to enhance advanced image visualization workflows by enabling content-sensitive hanging-protocols and auto-invocation of a computer aided detection algorithm for identified PA-AP chest images. Finally, we show that the same methodology could be utilized for several image parsing applications including anatomy/organ region of interest prediction and optimized image visualization.
Composite extension finite fields for low overhead Network Coding: Telescopic codes (2015)

Although Network Coding (NC) has been proven to increase throughput and reliability in communication networks, its adoption is typically hindered by the additional complexity it introduces at various nodes in the network and the overhead to signal the coding coefficients associated with each coded packet. This work advocates the use of multiple composite extension finite fields to address these challenges. The key of our approach is to design a series of finite fields where increasingly larger fields are based on a previous smaller field. For example, the design of a field with 256 elements F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2222</sub> is based on polynomial arithmetic over a field with 16 elements F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">222</sub> , in turn based on a field with 4 elements F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">22</sub> . We propose a technique to modify standard Random Linear Network Coding (RLNC) to utilize a set of these fields instead of a single field and analyze the performance. The results show that total overhead is reduced due to reduced size of the coding vector, while maintaining low linear dependency between coded packets. The overhead can in some cases be reduced to less than one-fifth compared to standard RLNC and importantly the ability to recode is preserved.
Rheolytic catheter for percutaneous removal of thrombus. (1992)

The authors present a percutaneous thrombectomy system (rheolytic thrombectomy catheter [RTC]) in which high-velocity jets of saline solution are used to lyse and remove thrombus. The catheters (4-6 F) direct a 10,000-15,000-psi (0.7-1.05 x 10(5)-kPa) jet of saline solution onto an exhaust port from orifices at the end of the catheter. The jet entrains clot and resulting fragments and brings them into the high-velocity region for lysis and removal. Whole blood clots (10-15 cm) placed in 6-9-mm-diameter tubing were completely dissolved and removed with the RTC in less than 1 minute. In vivo use in a canine model resulted in lysis and removal of clots from a femoral artery, without vessel damage. The small caliber, flexibility, and effective lysis of this system suggest its potential usefulness in large central vessels that are difficult to access surgically and in small-diameter vessels that require more rapid removal of thrombus than can be achieved with thrombolytic therapy.
Development of Polymeric Nonlinear Optical Material (1987)

Abstract The molecular structural characteristics which give rise to large optical nonlinearities have been delineated. This has been accomplished by several key steps and has led to the development of a structural algorithm for the design of β molecules with high susceptibilities. High activity molecular units have been covalently attached to form polymers which can contain up to 100% of the NLO moiety, and the resulting molecular optical properties have been characterized. The second order molecular susceptibility was found to be undiminished by properly designed covalent bonding to form a polymer, and spectral characteristics were found to closely follow that of the NLO unit.
Formation Characterization of A Horizontal Well While Drilling: An On-Site Tool (2000)

Abstract This paper describes a method of predicting formation pore pressure and permeability in a horizontal well during the drilling phase of a well development. Dependable and more accurate information about reservoir parameters such as permeability, pore pressure are indispensable for taking proper well completion decisions at a stage when the formation damage is minimal. In this study, a technique is described which can be used as an onsite tool for the evaluation of formation properties for horizontal wells. Method of analysis is based upon the buildup data collected during a test conducted at various stages of the wellbore penetration in the horizontal section while drilling. Modified well testing theory pertaining to horizontal wells is used for the interpretation of the test results. Examples of using simulated data are provided to demonstrate the practical application of the method. These examples using the proposed approach elaborated in this paper illustrate its practicability and the ease of usage as an onsite tool.
Partially coherent phase microscopy with arbitrary illumination source shape (2014)

We propose a method that recovers phase from a stack of through-focus intensity images taken with a partially coherent microscope employing illumination of any arbitrary source shape. Our algorithm uses a Kalman filtering approach, which is fast, accurate and robust to noise. We validate the method in simulation and with experimental data taken on a commercial microscope with varying condenser apertures in Köhler geometry.
Integrated single grating compressor for variable pulse front tilt in simultaneously spatially and temporally focused systems (2014)

A Ti:Al(3)O(2) multipass chirped pulse amplification system is outfitted with a single-grating, simultaneous spatial and temporal focusing (SSTF) compressor platform. For the first time, this novel design has the ability to easily vary the beam aspect ratio of an SSTF beam, and thus the degree of pulse-front tilt at focus, while maintaining a net zero-dispersion system. Accessible variation of pulse front tilt gives full spatiotemporal control over the intensity distribution at the focus and could lead to better understanding of effects such as nonreciprocal writing and SSTF-material interactions.
To improve silica glass for better optical properties (2003)

Silica glass, as a novel material for various optical applications, can be much more improved for a better quality of life. The present authors have found new structural relaxation channel(s) in the glass, in addition to the "main relaxation" caused by the viscous flow in the glass. The new relaxation channel(s) can be a new breakthrough to bring silica glass to a more stable less disordered structure, leading to improve many optical properties. The authors will put emphases on the transparency at infrared and the shift of absorption edge at ultraviolet.
Maintenance of corneal endothelial cell shape by prostaglandin E2: effects of EGF and indomethacin. (1986)

Confluent, cultured, rabbit corneal endothelial cells maintain a polygonal shape which is characteristic of these cells in vivo. When cultured in the presence of EGF (10 ng/ml) and/or indomethacin (1.0 microM), the endothelial cells have markedly different shapes at confluency. By morphometry, untreated cells are polygonal and have a maximum axis of 33 mu; EGF treatment causes a spindle-shaped elongation to 48 mu and indomethacin treatment causes a stellate-shaped elongation to 48 mu. There is a slight increase in cell density. When cells are cultured in the presence of both drugs, elongation is more pronounced to a fibroblastic appearing cell population, with maximum axes of 60 mu and more, but no additive increase in cell density. Continuity of cell borders is often lost. Corneal endothelial cells cultured in the presence of EGF, indomethacin, and PGE2 (0.5 microgram/ml) maintain their polygonal shape; PGF2 alpha is not effective at reversing the drugs' effects. Untreated and EGF-treated cells synthesize and release substantial quantities of PGE2 (2-4 ng/10(4) cells). Indomethacin completely inhibits PGE2 synthesis. It is concluded that PGE2 maintains the polygonal cell shape of the corneal endothelium in vitro and, perhaps, in vivo. The elongated forms of the cell may be related to migration and important in wound closure.