gebhart/patrepeval huggingface dataset:
[Sperm acrosome reaction detection in intrauterine insemination]. (2011)

The spontaneous AR rate has nothing to do with the clinical pregnancy rate of IUI, but the induced AR rate is associated with the clinical pregnancy rate of IUI.
Multiattribute Monitoring of Antibody Charge Variants by Cation-Exchange Chromatography Coupled to Native Mass Spectrometry (2021)

The aim of this study was to characterize the product variants of a therapeutic T-cell bispecific humanized monoclonal antibody (TCB Mab, ∼200 kDa, asymmetric) and to develop an online cation-exchange chromatography native electrospray mass spectrometry method (CEC-UV-MS) for direct TCB Mab charge variant monitoring during bioprocess and formulation development. For the identification and functional evaluation of the diverse and complex TCB Mab charge variants, offline fractionation combined with comprehensive analytical testing was applied. The offline fractionation of abundant product variant peaks enabled identification of coeluting acid charge variants such as asparagine deamidation, primary and secondary Fab glycosylation (with and without sialic acid), and the presence of O-glycosylation in the G4S-linker region. Consequently, a new nonconsensus N-glycosylation motif (N-338-FG) in the heavy chain CDR region was discovered. Functional evaluation by cell-based potency testing demonstrated a clear and negative impact of both asparagine deamidations, whereas the O-glycosylation did not affect the TCB Mab biological activity. We established an online native CEC-UV-MS method, with an ammonium acetate buffer and pH gradient, to directly monitor the TCB Mab charge variants. All abundant chemical degradations and post-translational amino acid modifications already identified by offline fraction experiments and liquid chromatography mass spectrometry peptide mapping could also be monitored by the online CEC-UV-MS method. The herein reported online native CEC-UV-MS methodology represents a complementary or even alternative approach for multiattribute monitoring of biologics, offering multiple benefits, including increased throughput and reduced sample handling and intact protein information in the near-native state.
Zigzag graphene nanoribbon edge reconstruction with Stone-Wales defects (2011)

In this paper, we study zigzag graphene nanoribbons with edges reconstructed with Stone-Wales defects, by means of an empirical (first-neighbor) tight-binding method, with parameters determined by ab initio calculations of very narrow ribbons. We explore the characteristics of the electronic band structure with a focus on the nature of edge states. Edge reconstruction allows the appearance of a new type of edge states. They are dispersive, with nonzero amplitudes in both sublattices; furthermore, the amplitudes have two components that decrease with different decay lengths with the distance from the edge; at the Dirac points one of these lengths diverges, whereas the other remains finite, of the order of the lattice parameter. We trace this curious effect to the doubling of the unit cell along the edge, brought about by the edge reconstruction. In the presence of a magnetic field, the zero-energy Landau level is no longer degenerate with edge states as in the case of the pristine zigzag ribbon.
Analysis of success factors for a new product development initiative in Indian automotive industry: an ISM approach (2017)

This paper aims at analysing various factors driving towards success of new product development (NPD) initiatives in Indian automotive industry. The present research has been carried out in three phases: identification of factors from the literature, survey of Indian automotive industries, and qualitative analysis using interpretive structural modelling (ISM) for studying the interaction among the factors. The knowledge of dominating success factors, and the adoption of such an ISM-based model of success factors for NPD would assist decision makers and practitioners of new product development in focusing their resources on these major factors while undertaking new product ventures at their organisation. The study is carried out for identifying and analysing the critical success factors for NPD in Indian automotive sector.
Revisiting Non-Progressive Influence Models: Scalable Influence Maximization (2014)

While influence maximization in social networks has been studied extensively in computer science community for the last decade the focus has been on the progressive influence models, such as independent cascade (IC) and Linear threshold (LT) models, which cannot capture the reversibility of choices. In this paper, we present the Heat Conduction (HC) model which is a non-progressive influence model with real-world interpretations. We show that HC unifies, generalizes, and extends the existing nonprogressive models, such as the Voter model [1] and non-progressive LT [2]. We then prove that selecting the optimal seed set of influential nodes is NP-hard for HC but by establishing the submodularity of influence spread, we can tackle the influence maximization problem with a scalable and provably near-optimal greedy algorithm. We are the first to present a scalable solution for influence maximization under nonprogressive LT model, as a special case of the HC model. In sharp contrast to the other greedy influence maximization methods, our fast and efficient C2GREEDY algorithm benefits from two analytically computable steps: closed-form computation for finding the influence spread as well as the greedy seed selection. Through extensive experiments on several large real and synthetic networks, we show that C2GREEDY outperforms the state-of-the-art methods, in terms of both influence spread and scalability.
Hdm2 Nuclear Export, Regulated by Insulin-like Growth Factor-I/MAPK/p90Rsk Signaling, Mediates the Transformation of Human Cells (2006)

Insulin-like growth factor (IGF)-I receptor activation leads to enhanced proliferation and cell survival via the MAP kinase and phosphatidylinositol 3-kinase-signaling pathways. Upon stimulation by IGF-I, the Hdm2 oncoprotein is phosphorylated by AKT, leading to its rapid nuclear translocation and subsequent inhibition of p53. We now show that IGF-I stimulation regulates the nuclear export of Hdm2 and p53 via the MAP kinase pathway. Inhibition of p38 MAPK or MEK via pharmacological means or expression of dominant negative proteins inhibited the cytoplasmic accumulation of Hdm2 and increased Hdm2 and p53 protein levels, whereas constitutively active p90Rsk promoted the nuclear export of Hdm2. Expression of constitutively active p90Rsk with E1A, oncogenic H-Ras, and hTERT resulted in the anchorage-independent growth of normal human fibroblasts. Our findings link p90Rsk-mediated modulation of Hdm2 nuclear to cytoplasmic shuttling with the diminished ability of p53 to regulate cell cycle checkpoints that ultimately leads to transformation.
Flower-like hierarchical h-MoO3: new findings of efficient visible light driven nano photocatalyst for methylene blue degradation (2013)

Hexagonal molybdenum oxide (h-MoO3) nanocrystals with a flower-like hierarchical structure have been successfully synthesized by a solution based self assembly route. The as-synthesized h-MoO3 was recognized as a photocatalyst for the photocatalytic degradation of methylene blue (MB) under various experimental conditions. Initially, the as-synthesized h-MoO3 was characterized by different physico-chemical techniques in order to study and reveal the structural, functional, morphological, and optical properties. The results indicated that the photocatalyst has a hexagonal crystal structure with an average crystallite size of 46 nm. The morphology analysis has proved that the h-MoO3 comprises one dimensional (1D) rods with a hexagonal cross section. The possible formation mechanism is proposed as a self assembly process for nucleation and an Ostwald ripening mechanism for particle growth. The optical band gap investigation showed that the Eg value of h-MoO3 (2.94 eV) lies in the visible region and can be an appropriate candidate for visible light photocatalytic application. Furthermore, the experimental observations demonstrate an excellent photocatalytic performance of h-MoO3 in the degradation of MB under visible light irradiation.
Polymer compatibility with and without a solvent (1982)

Abstract A qualitative review of the thermodynamics of polymer systems will be given in terms of three contributions: positional (or combinatorial) entropy, an “international” term and a free volume term. From this one finds that a simple polymer‐solvent system phase separates on lowering T to an Upper Critical Solution Temperature (UCST) or raising it to Lower Critical Solution Temperature (LCST), To achieve miscibility of two polymers of high molecular weight, one requires a “specific” interaction, usually a weak charge‐transfer complex or a hydrogen bond. Phase separation takes place on raising the temperature to an LCST. These various UCST and LCST are predicted semi‐quantitative by the Prigogine‐Flory theory. When a solvent is added to two miscible polymers, a new type of phase separation appears since there is an effect of any difference in the strengths of the two polymer‐solvent interactions. Phase separation may easily occur in the ternary system where there is none in the three binary systems, and examples will be given. In the case of two highly‐attractive polymers in a solvent, a quite different phase separation occurs, sometimes called complex coacervation. A simple Flory‐Huggins type theory predicts these phenomena in ternary systems.
Magnetic and magnetoelectric susceptibilities of a ferroelectric/ferromagnetic composite at microwave frequencies (2002)

A phenomenological theory of magnetic and magnetoelectric (ME) susceptibilities of ferroelectric/ferromagnetic composites is presented and applied to the special case of layered structures. Expressions have been obtained relating the magnetic and ME susceptibility tensor components of the composite (symmetry point group $3m$ and $4mm)$ to ME coupling constants. The theory predicts a unique resonance in the electric-field dependence of the magnetic susceptibility. It is shown that the ME susceptibility is the product of magnetic susceptibility, composite magnetization, and ME coupling constants. The model is used to obtain the magnetic and ME susceptibilities versus electric-field profiles for three bilayer composites of importance: lithium ferrite (LFO)--lead zirconate titanate (PZT), nickel ferrite (NFO)-PZT, and yttrium iron garnet (YIG)-PZT. Our calculations reveal the largest electric-field effects for NFO-PZT and the weakest effect for YIG-PZT. Three measurement methods for ME susceptibility, resonant ME coupling, electrical dipole transitions, and ME effect at ferromagnetic resonance (FMR) are proposed. As an example, we consider multilayers of LFO-PZT and determine the ME constants from data on electric-field influence on FMR. The ME parameters are then used to calculate the susceptibilities. The results indicate strong high-frequency ME effects in the composite. The theory is useful for measurements of ME susceptibility and for the design and analysis of electrically controlled high-frequency magnetic devices.
Effects of a 21-aminosteroid (U-74006F) on cerebral metabolites and edema after severe experimental head trauma. (1990)

U-74006F, a 21-aminosteroid, is a potent inhibitor of CNS tissue LP in vitro. In this study it was tested for effects on brain edema and metabolites after impact injury to the closed skull. Anesthetized cats were blindly treated with U-74006F or vehicle at 30 min (1 mg/kg) and 2.5 hr (0.5 mg/kg) after head or sham injury. They were sacrificed 4 hr after injury by in situ fixation of the brain. Head-injured cats were selected for unilateral (left) cerebral contusion. Metabolites (enzyme fluorometry) and edema (specific gravity) were measured in the cerebral cortex and white matter bilaterally. Cerebral hemisphere, contusion, and vasogenic edema volumes were morphometrically measured. Magnitude of edema and metabolites in tissue with vasogenic edema was similar in vehicle- and drug-treated cats. By contrast, the cortex and nonedematous white matter neighboring contusion in drug-treated cats had lactate, glucose, and glycogen levels that suggested an improved metabolic state over vehicle treatment. Most metabolites were not affected by trauma or treatment in the uncontused hemisphere. These results suggest that postinjury treatment with the nonglucocorticoid steroid U-74006F may benefit the metabolism of nonedematous tissue adjacent to contusion.
Identification and classification of chemicals using terahertz reflective spectroscopic focal-plane imaging system (2006)

We present terahertz (THz) reflective spectroscopic focal-plane imaging of four explosive and bio-chemical materials (2, 4-DNT, Theophylline, RDX and Glutamic Acid) at a standoff imaging distance of 0.4 m. The 2 dimension (2-D) nature of this technique enables a fast acquisition time and is very close to a camera-like operation, compared to the most commonly used point emission-detection and raster scanning configuration. The samples are identified by their absorption peaks extracted from the negative derivative of the reflection coefficient respect to the frequency (-dr/dv) of each pixel. Classification of the samples is achieved by using minimum distance classifier and neural network methods with a rate of accuracy above 80% and a false alarm rate below 8%. This result supports the future application of THz time-domain spectroscopy (TDS) in standoff distance sensing, imaging, and identification.
Internal stress in plasma polymer films prepared by cascade arc torch polymerization (1999)

Thin plasma polymer films were deposited from several liquid monomers (mainly siloxane-type monomers) in a low-temperature cascade arc torch (CAT) reactor. The effects of monomer structures and plasma parameters on internal stress in the films were experimentally studied. By appropriately adjusting these factors, the internal stress in the film was reduced nearly two orders of magnitude from 109 to 107 dyn/cm2. It was noted that the polymer films prepared from siloxane-type monomers showed lower internal stress than their hydrocarbon counterpart. Fourier transform-infrared spectroscopy (FTIR) studies indicated that a large amount of SiOSi structure from siloxane monomers, which are very flexible bonds, was preserved in the resultant plasma polymers. Ellipsometry results suggested that the internal stress can be qualitatively correlated with the refractive index of the plasma polymer film. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 1577–1587, 1999
Decoding material-specific memory reprocessing during sleep in humans (2017)

Neuronal learning activity is reactivated during sleep but the dynamics of this reactivation in humans are still poorly understood. Here we use multivariate pattern classification to decode electrical brain activity during sleep and determine what type of images participants had viewed in a preceding learning session. We find significant patterns of learning-related processing during rapid eye movement (REM) and non-REM (NREM) sleep, which are generalizable across subjects. This processing occurs in a cyclic fashion during time windows congruous to critical periods of synaptic plasticity. Its spatial distribution over the scalp and relevant frequencies differ between NREM and REM sleep. Moreover, only the strength of reprocessing in slow-wave sleep influenced later memory performance, speaking for at least two distinct underlying mechanisms between these states. We thus show that memory reprocessing occurs in both NREM and REM sleep in humans and that it pertains to different aspects of the consolidation process.
Scintillation Properties of SrHfO :Ce and BaHfO :Ce Ceramics (2007)

In this paper we report on the scintillation properties of cerium doped strontium—and barium hafnate. Radiolumi- nescence, pulse height, scintillation decay and timing spectra are presented. Radioluminescence spectra of SrHfO :Ce and BaHfO :Ce consist of a broad band due to Ce emission peaking at 410 nm and 400 nm, respectively. The light yield of BaHfO :Ce and SrHfO :Ce is approximately 40 000 photons/MeV when compared to a crystal of BGO. The principal decay time constant for SrHfO :Ce and BaHfO :Ce is 42 and 25 ns, respectively. A timing resolution of 276 ps (FWHM) was obtained with transparent optical ceramic of SrHfO :Ce . Index Terms—Ceramics, cerium compounds, hafnium com- pounds, scintillation detectors.
Effect of textile materials on wearable antenna performance: a case study of GPS antennas (2004)

Recently, textile antennas have been presented in international conferences. These studies have demonstrated that fabrics are suitable for microstrip antenna substrates. In this paper, our study focuses on the characterization of different synthetic fabrics suitable for circular polarized micro-strip antennas. Special attention is paid to GPS antennas. Five different synthetic textile materials are chosen for the comparison. The word textile is typically used for antenna class and fabric to describe a particular material. However, in many cases these words are interchangeable.
<p>Targeting Trop-2 in solid tumors: future prospects</p> (2019)

Trop-2 is a transmembrane glycoprotein that is upregulated in all cancer types independent of baseline levels of Trop-2 expression. Trop-2 is an ideal candidate for targeted therapeutics due to it being a transmembrane protein with an extracellular domain overexpressed on a wide variety of tumors as well as its upregulated expression relative to normal cells. As a result, several Trop-2-targeted therapeutics have recently been developed for clinical use, such as anti-Trop-2 antibodies and Trop-2-targeted antibody-drug conjugates (ADC). Subsequently, multiple early-phase clinical trials have demonstrated safety and clinical benefit of Trop-2-based ADCs across multiple tumor types. This includes clinical benefit and tolerability in tumor types with limited treatment options, such as triple-negative breast cancer, platinum-resistant urothelial cancer, and small-cell lung cancer. In this review, we elaborate on all clinical trials involving Trop-2.
PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD (2018)

Stimulation of N-methyl-D-aspartic acid receptors (NMDARs) and the resulting increase of nitric oxide (NO) production are critical for fear memory formation. Following NMDAR activation, efficient production of NO requires linking the 95 kDa postsynaptic density protein (PSD95), a scaffolding protein to neuronal nitric oxide synthase (nNOS). A variety of previously studied NMDAR antagonists and NOS inhibitors can disrupt fear conditioning, but they also affect many other CNS functions such as motor activity, anxiety, and learning. We hypothesized that disrupting nNOS and PSD95 interaction in the amygdala, a critical site for fear memory formation, will reduce conditioned fear. Our results show that systemic treatment with ZL006, a compound that disrupts PSD95/nNOS binding, attenuates fear memory compared to its inactive isomer ZL007. Co-immunoprecipitation after fear conditioning showed a robust increase in the amygdala PSD95/nNOS binding, which was blocked by systemic pre-administration of ZL006. Treatment of amygdala slices with ZL006 also impaired long-term potentiation (LTP), a cellular signature of synaptic plasticity. Direct intra-amygdala infusion of ZL006 also attenuated conditioned fear. Finally, unlike NMDAR antagonist MK-801, ZL006 does not affect locomotion, social interaction, object recognition memory, and spatial memory. These findings support the hypothesis that disrupting the PSD95/nNOS interaction downstream of NMDARs selectively reduces fear memory, and highlights PSD95/nNOS interaction as a novel target for fear-related disorders, such as posttraumatic stress disorder.
A generalized resultant matrix for polynomial matrices (1976)

We present a generalized resultant matrix and a fast algorithm for testing the coprimeness of two polynomial matrices, extracting their great common divisor, finding the McMillan degree and the observability indices of the associated minimal realization.
Mucha Lucha! Building a Brand (2017)

This case takes advantage of the culinary genius and entrepreneurial spirit of Chef Victor and parleys his creations into the challenge of building a brand image that will create distinctiveness in a highly competitive homogenous market. Mucha Lucha represents the aspects of Mexican culture that includes masks and wrestling–signature moves. The literal translation is “a lot of fight,” referring to the famed Mexican wrestling, lucha libre. For the restaurant in the case, it presents a unique slice of Mexican culture that few, if any, traditional restaurants use. This includes the reference of lucha libre wrestling artifacts on the restaurant walls and within the themes of the restaurant. The case has a difficulty level that will challenge senior-level marketing students, or graduate students, to develop a strategic marketing plan that will unite and identify the various business units. The case may serve as an individual or team project. Independent research is highly recommended and a minimum of two weeks is recommended prep time for students to develop and refine their ideas.
Predictable Low-Latency Event Detection With Parallel Complex Event Processing (2015)

The tremendous number of sensors and smart objects being deployed in the Internet of Things (IoT) pose the potential for IT systems to detect and react to live-situations. For using this hidden potential, complex event processing (CEP) systems offer means to efficiently detect event patterns (complex events) in the sensor streams and therefore, help in realizing a “distributed intelligence” in the IoT. With the increasing number of data sources and the increasing volume at which data is produced, parallelization of event detection is crucial to limit the time events need to be buffered before they actually can be processed. In this paper, we propose a pattern-sensitive partitioning model for data streams that is capable of achieving a high degree of parallelism in detecting event patterns, which formerly could only consistently be detected in a sequential manner or at a low parallelization degree. Moreover, we propose methods to dynamically adapt the parallelization degree to limit the buffering imposed on event detection in the presence of dynamic changes to the workload. Extensive evaluations of the system behavior show that the proposed partitioning model allows for a high degree of parallelism and that the proposed adaptation methods are able to meet a buffering limit for event detection under high and dynamic workloads.
Improving the Quality of Rural Living through Water and Wastewater Services (1995)

The complementary strands of adenovirus type 2 (Ad2) DNA were separated by buoyant density gradient centrifugation with poly (U, G). The complementary strand DNA was shown to remain intact through the course of strand separation. The l-strand of Ad2 DNA, appearing in the less dense complex with poly (U, G) in neutral CsCl density gradients, was shown to have a buoyant density in alkaline (pH 12.5) CsCl density gradients which is 2 to 3 mg per ml greater than that of its complement (h-strand). Renaturation of purified complementary strand DNA was observed only in mixtures of h- and l-strand DNA, and then with the second-order reaction rate expected for Ad2 DNA. Hybridization of the complementary strands of Ad2 DNA with cytoplasmic mRNA isolated from infected HeLa cells was performed in liquid phase and analyzed by hydroxylapatite chromatography. Before viral DNA synthesis (6 h after infection), 13 to 18% of the h-strand and 30 to 35% of the l-strand were represented in viral mRNA. Late (18 h) after infection the mRNA represented 20 to 25% and 63 to 68% of the h- and l-strands, respectively. Most, if not all sequences present in viral mRNA before viral DNA synthesis were also present in the cytoplasm late in infection.