gebhart/patrepeval huggingface dataset:
Basic Biological Sciences (1985)

It has been shown in laboratory and animal studies that tooth enamel becomes considerably more reactive toward low levels of fluoride after receiving pre-treatment which forms dicalcium phosphate dihydrate (DCPD) in the enamel as an intermediate. This in vitro study was undertaken to determine the effect on human enamel fluoride uptake of incorporating DCPD-forming rinses into a conventional fluoride rinsing program. In one group, enamel samples received a one-minute rinse with 0.2% NaF each day for 20 days. Samples in the second group were treated identically, except that they were also given a one-minute DCPD-forming rinse prior to the first, sixth, eleventh, and sixteenth fluoride rinses. At the end of the rinsing program, all samples were washed in 1 M KOH to remove labile fluorides. The enamel biopsy data showed that the fluoride uptake resulting from 0.2% NaF alone was not statistically significant, whereas uptake produced by the DCPD-forming plus NaF rinses was significant. The results suggest that the DCPD-forming rinse may improve the efficacy of fluoride rinse programs.
Non-Caloric Sweeteners, Sweetness Modulators, and Sweetener Enhancers (2012)

For a new sweetness technology to realize strong commercial success, it must be safe, exhibit good taste quality, be sufficiently soluble and stable in food and beverage systems, and be cost effective and patentable. Assessments of the commercial promise of eight synthetic and eight natural non-caloric sweeteners are made relevant to these metrics. High-potency (HP) non-caloric sweeteners, both synthetic and natural, are generally limited in taste quality by (a) low maximal sweetness response, (b) "off" tastes, (c) slow-onset sweet tastes that linger, and (d) sweet tastes that adapt or desensitize the gustatory system. Formulation approaches to address these limitations are discussed. Enhancement of the normal sucrose sensory response by action of a sweetener receptor positive allosteric modulator (PAM) has been achieved with very significant calorie reduction and with retention of the taste quality of sucrose. Research on PAM discovery over the past decade is summarized.
Laser induced fluorescence imaging of thermal damage in polymer matrix composites (1997)

A simple, fluorescence based imaging system has been developed that is capable of identifying regions of thermal damage in polymer matrix composites (PMCs). These materials are playing an increasingly important role in the production of high performance vehicles and aircraft, where their low weight and high mechanical strength, combined with advancements in manufacturing technology, ensure increased use for a variety of applications. Of particular concern in the aerospace industry is the tendency of some PMC materials to become irreversibly damaged when exposed to elevated temperatures. Traditional nondestructive testing (NDT) techniques are capable of detecting physical anomalies such as cracks and delaminations but cannot detect initial heat damage, which occurs on a molecular scale. Spectroscopic techniques such as laser induced fluorescence provide an attractive means for detecting this type of damage and are amenable to imaging large, irregularly shaped surfaces. In this report the authors describe instrumentation capable of rapidly detecting thermal damage in graphite epoxy components and suggest improvements which will enable this technology to make quantitative judgments concerning the mechanical strength properties of heat damaged specimens.
Ultra-Broadband Optical Gain in III-Nitride Digital Alloys (2018)

A novel III-Nitride digital alloy (DA) with ultra-broadband optical gain is proposed. Numerical analysis shows a 50-period InN/GaN DA yields minibands that are densely quantized by numerous confined states. Interband transitions between the conduction and valence minibands create ultra-broadband optical gain spectra with bandwidths up to ~1 μm that can be tuned from the red to infrared. In addition, the ultra-broadband optical gain, bandwidth, and spectral coverage of the III-Nitride DA is very sensitive to layer thickness and other structural design parameters. This study shows the promising potential of the III-Nitride DAs with tunable ultra-broadband interband optical gain for use in semiconductor optical amplifiers and future III-Nitride photonic integration applications.
Pulse-echo ultrasonic wave-energy imaging system incorporating high-angular velocity oscillated transducer (1982)

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Enantioselective Fluoroamination: 1,4‐Addition to Conjugated Dienes Using Anionic Phase‐Transfer Catalysis (2013)

Chiral-anion phase-transfer catalysis (PTC) has been applied towards the enantioselective fluorocyclization reactions of 1,3-dienes. The method affords unprecedented fluorinated benz[f]isoquinoline and octahydroisoquinoline products in high yields and up to 96 % ee. New fluorinated amine reagents outperformed Selectfluor in the desired transformation.
The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate (2016)

The cell adhesion molecule Nectin-4 is overexpressed in epithelial cancers, including ovarian cancer. The objective of this study was to determine the biological significance of Nectin-4 in the adhesion, aggregation, migration, and proliferation of ovarian cancer cells. Nectin-4 and its binding partner Nectin-1 were detected in patients' primary tumors, omental metastases, and ascites cells. The human cell lines NIH:OVCAR5 and CAOV3 were genetically modified to alter Nectin-4 expression. Cells that overexpressed Nectin-4 adhered to Nectin-1 in a concentration and time-dependent manner, and adhesion was inhibited by antibodies to Nectin-4 and Nectin-1, as well as synthetic Nectin peptides. In functional assays, CAOV3 cells with Nectin-4 knock-down were unable to form spheroids and migrated more slowly than CAOV3 parental cells expressing Nectin-4. NIH:OVCAR5 parental cells proliferated more rapidly, migrated faster, and formed larger spheroids than either the Nectin-4 knock-down or over-expressing cells. Parental cell lines expressed higher levels of epithelial markers and lower levels of mesenchymal markers compared to Nectin-4 knock-down cells, suggesting a role for Nectin-4 in epithelial-mesenchymal transition. Our results demonstrate that Nectin-4 promotes cell-cell adhesion, migration, and proliferation. Understanding the biology of Nectin-4 in ovarian cancer progression is critical to facilitate its development as a novel therapeutic target.
Max Consensus in Sensor Networks: Non-linear Bounded Transmission and\n Additive Noise (2016)

A distributed consensus algorithm for estimating the maximum value of the\ninitial measurements in a sensor network with communication noise is proposed.\nIn the absence of communication noise, max estimation can be done by updating\nthe state value with the largest received measurements in every iteration at\neach sensor. In the presence of communication noise, however, the maximum\nestimate will incorrectly drift and the estimate at each sensor will diverge.\nAs a result, a soft-max approximation together with a non-linear consensus\nalgorithm is introduced herein. A design parameter controls the trade-off\nbetween the soft-max error and convergence speed. An analysis of this trade-off\ngives a guideline towards how to choose the design parameter for the max\nestimate. We also show that if some prior knowledge of the initial measurements\nis available, the consensus process can converge faster by using an optimal\nstep size in the iterative algorithm. A shifted non-linear bounded transmit\nfunction is also introduced for faster convergence when sensor nodes have some\nprior knowledge of the initial measurements. Simulation results corroborating\nthe theory are also provided.\n
Discharge Quality Estimation and Significant Feature Identification in Micro-Electrical Discharge Machining (1997)

Abstract We present a method for estimating the quality of a measured discharge train in Micro-EDM processes. In contrast to generic EDM, Micro-EDM is characterized by a higher frequency of discharges and is used for machining smaller features, thus making regulation more difficult. In this paper, a system similar to a fuzzy rule based classification is used to identify good and bad disharges based on discharge quality. In addition to traditional machining quality issues, we include parameters that illustrate the degree of control of the voltage pulse input over the spark gap. To aid the formulation of quick closed loop control schemes for Micro-EDM, a method for identifying the parameter/sensor that separates best the good and bad discharges, is presented. The use of this method in closed loop control schemes for Micro-EDM is discussed.
Generation and preclinical characterization of an antibody specific for SEMA4D (2015)

Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. Blocking the binding of SEMA4D to its receptors can result in physiologic changes that may have implications in cancer, autoimmune, and neurological disease. To study the effects of blocking SEMA4D, we generated, in SEMA4D-deficient mice, a panel of SEMA4D-specific hybridomas that react with murine, primate, and human SEMA4D. Utilizing the complementarity-determining regions from one of these hybridomas (mAb 67-2), we generated VX15/2503, a humanized IgG4 monoclonal antibody that is currently in clinical development for the potential treatment of various malignancies and neurodegenerative disorders, including multiple sclerosis and Huntington's disease. This work describes the generation and characterization of VX15/2503, including in vitro functional testing, epitope mapping, and an in vivo demonstration of efficacy in an animal model of rheumatoid arthritis.
Low noise, throttling valve (1981)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Fritz Kalb, Silvan Fehlisch, Otto Ziegert, Hans Bender, Manfred Schmitt; Low noise, throttling valve. J. Acoust. Soc. Am. 1 January 1981; 69 (1): 336. https://doi.org/10.1121/1.385261 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Cybersecurity Vulnerability Mitigation Framework Through Empirical Paradigm (CyFEr): Prioritized Gap Analysis (2019)

Cybersecurity vulnerability assessment tools, frameworks, methodologies, and processes are commonly used to understand the cybersecurity maturity and posture of a system or a facility. Although those tools are strictly developed based on standards defined by organizations such as the National Institute of Standards and Technology (NIST) and the U.S. Department of Energy, the majority of these tools and frameworks do not provide a platform to prioritize the requirements to reach a desired cybersecurity maturity. To address that challenge, we have been developing a framework and a software application called the cybersecurity vulnerability mitigation framework through empirical paradigm (CyFEr). The efficacy of CyFEr was evaluated by implementing it on the NIST cybersecurity framework (CSF). This paper provides a detailed architecture of CyFEr and demonstrates its application to CSF by testing against a real-world cyberattack that targeted industrial control systems in a critical infrastructure facility.
G151 Development of the Microwave Reduced-Pressure Drying System with Air Ventilation (2005)

We have developed a microwave reduced-pressure drying as a new method replacing the warm -air drying. The drying time of seafood was successfully shortened to about 1/20 of the warm-air drying by the temperature control and it resulted in the good quality of drying. In this report, we made a small -scale prototype of drying equipment and investigated the energy efficiency and the drying characteristics of scallops. It was found that the maximum value of the energy efficiency was attained at the microwave power of 12.5W per one scallop. We can raise the energy efficiency to about 55% by the temperature control.
Indirect flat-panel detector with avalanche gain (2004)

A new concept - an indirect flat-panel detector with avalanche gain - for low dose x-ray imaging has been proposed. The detector consists of an amorphous selenium (a-Se) photoconductor optically coupled to a structured cesium iodide (CsI) scintillator. Under an electric field E<sub>Se</sub>, the a-Se is sensitive to light and converts the optical photons emitted from CsI into electronic signal. These signals can be stored and read out in the same fashion as in existing flat-panel detectors. When E<sub>Se</sub> is increased to > 90 V/μm, avalanche multiplication occurs. The avalanche gain ranges between 1-800 depending on E<sub>Se</sub> and the thickness of the a-Se layer d<sub>Se</sub>. The avalanche a-Se photoconductor is referred to as HARP (High-gain Avalanche Rushing amorphous Photoconductor). A cascaded linear system model for the proposed detector was developed in order to determine the optimal CsI properties and avalanche gain for different x-ray imaging applications. Our results showed that x-ray quantum noise limited performance can be achieved at the lowest exposure level necessary for fluoroscopy (0.1 μR) and mammography (0.1 mR) with a moderate avalanche gain of 20 (d = 1-2 μm). A laboratory test system using an existing HARP tube optically coupled (through a lens) to a CsI layer was built and the advantage of avalanche gain in overcoming electronic noise was demonstrated experimentally. One of the advantages of the avalanche gain is that it will permit the use of high resolution (HR) CsI (which due to its low light output has not previously been used in flat-panel detectors) to improve DQE at high spatial frequencies.
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers (2014)

Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising therapeutic candidates. We therefore set out to systematically interrogate epigenetic cancer dependencies by screening an epigenome-focused deep-coverage design shRNA (DECODER) library across 58 cancer cell lines. This screen identified BRM/SMARCA2, a DNA-dependent ATPase of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex, as being essential for the growth of tumor cells that harbor loss of function mutations in BRG1/SMARCA4. Depletion of BRM in BRG1-deficient cancer cells leads to a cell cycle arrest, induction of senescence, and increased levels of global H3K9me3. We further demonstrate the selective dependency of BRG1-mutant tumors on BRM in vivo. Genetic alterations of the mSWI/SNF chromatin remodeling complexes are the most frequent among chromatin regulators in cancers, with BRG1/SMARCA4 mutations occurring in ∼10-15% of lung adenocarcinomas. Our findings position BRM as an attractive therapeutic target for BRG1 mutated cancers. Because BRG1 and BRM function as mutually exclusive catalytic subunits of the mSWI/SNF complex, we propose that such synthetic lethality may be explained by paralog insufficiency, in which loss of one family member unveils critical dependence on paralogous subunits. This concept of "cancer-selective paralog dependency" may provide a more general strategy for targeting other tumor suppressor lesions/complexes with paralogous subunits.
Serum starvation improves transient transfection efficiency in differentiating embryonic stem cells (2010)

Control of genetic expression is a critical issue in the field of stem cell biology, where determining a cell fate or reprogramming adult somatic cells into pluripotent cells has become a common experimental practice. In turn, for these cells to have therapeutic clinical potential, techniques for controlling gene expression are needed that minimizes or eliminates the risk of oncogenesis and mutagenesis. Possible routes for achieving this outcome could come in the form of a transient nonviral gene delivery system. In this study, we improved the efficiency of transient gene delivery to differentiating murine embryonic stem (ES) cells via serum starvation for 3 days before transfection. The transient expression of a constitutively-controlled plasmid increased from ∼50% (replated control) to ∼83% when transfected after 3 days of serum starvation but decreased to ∼28% when transfected after 3 days in normal high serum-containing media. When probed with a liver-specific reporter, Cyp7A1, expression increased from ∼1.4% (replated control) to ∼3.7% when transfected after 3 days of serum starvation but decreased to ∼0.7% when transfected after 3 days in high serum-containing media. Cy3-tagged oligonucleotides were used to rapidly quantify DNA uptake and predict ultimate transfection efficiency. This study suggests that modifications in media serum levels before transfection can have a profound effect on improving nonviral gene delivery.
Cloud-Based Multimedia Content Protection System (2015)

We propose a new design for large-scale multimedia content protection systems. Our design leverages cloud infrastructures to provide cost efficiency, rapid deployment, scalability, and elasticity to accommodate varying workloads. The proposed system can be used to protect different multimedia content types, including 2-D videos, 3-D videos, images, audio clips, songs, and music clips. The system can be deployed on private and/or public clouds. Our system has two novel components: (i) method to create signatures of 3-D videos, and (ii) distributed matching engine for multimedia objects. The signature method creates robust and representative signatures of 3-D videos that capture the depth signals in these videos and it is computationally efficient to compute and compare as well as it requires small storage. The distributed matching engine achieves high scalability and it is designed to support different multimedia objects. We implemented the proposed system and deployed it on two clouds: Amazon cloud and our private cloud. Our experiments with more than 11,000 3-D videos and 1 million images show the high accuracy and scalability of the proposed system. In addition, we compared our system to the protection system used by YouTube and our results show that the YouTube protection system fails to detect most copies of 3-D videos, while our system detects more than 98% of them. This comparison shows the need for the proposed 3-D signature method, since the state-of-the-art commercial system was not able to handle 3-D videos.
Limited feedback designs for two-way relaying systems with physical network coding (2015)

This paper considers a limited feedback system for two-way wireless relaying channels with physical network coding (PNC). For full feedback systems, the optimal structure with the PNC has already been studied where a modulo operation is employed. In this case, phase and power of two end node channels are adjusted to maximize the minimum distance. Based on this result, we design new quantization methods for the phase and the power in the limited feedback system. By investigating the minimum distance of the received constellation, we present a codebook design to maximize the worst minimum distance. Especially, for quantization of the power for 16-QAM, a new power quantization scheme is proposed to maximize the performance. Also, utilizing the characteristics of the minimum distance observed in our code-book design, we present a power allocation method which does not require any feedback information. Simulation results confirm that our proposed scheme outperforms conventional systems with reduced complexity.
A 700-W peak ultra-wideband broadcast Doherty amplifier (2014)

A wideband high-power Doherty design technique enabling fractional bandwidths > 50% is described. It utilizes wideband impedance inversion, device output capacitance compensation and passive phase-optimized wideband input-signal splitting. As prove of concept a LDMOS based ultra-wideband broadcast Doherty amplifier is presented, which covers the UHF-TV 470MHz–803MHz (BW <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rel</inf> = 52%) band with average efficiencies between 38%–47% @P <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">avg</inf> > 115W while maintaining peak power capability > 700W over the entire band. Predistortability is demonstrated by satisfying the digital TV linearity requirements (−38dBc) using a commercial DVB-T exciter. The proposed DPA is an excellent drop-in replacement for the low-efficiency wideband PA blocks currently in use in broadcast transmitters.
Ion Funnel Trap Interface for Orthogonal Time-of-Flight Mass Spectrometry (2007)

A combined electrodynamic ion funnel and ion trap coupled to an orthogonal acceleration (oa)-time-of-flight mass spectrometer was developed and characterized. The ion trap was incorporated through the use of added terminal electrodynamic ion funnel electrodes enabling control over the axial dc gradient in the trap section. The ion trap operates efficiently at a pressure of approximately 1 Torr, and measurements indicate a maximum charge capacity of approximately 3 x 10(7) charges. An order of magnitude increase in sensitivity was observed in the analysis of low concentration peptides mixtures with orthogonal acceleration (oa)-time-of-flight mass spectrometry (oa-TOF MS) in the trapping mode as compared to the continuous regime. A signal increase in the trapping mode was accompanied by reduction in the chemical background, due to more efficient desolvation of, for example, solvent related clusters. Controlling the ion trap ejection time was found to result in efficient removal of singly charged species and improving signal-to-noise ratio (S/N) for the multiply charged analytes.
Regulation of dendritic cell trafficking: a process that involves the participation of selective chemokines (1999)

DC function as sentinels of the immune system. They traffic from the blood to the tissues where, while immature, they capture antigens. They then leave the tissues and move to the draining lymphoid organs where, converted into mature DC, they prime naive T cells. This suggestive link between DC traffic pattern and functions led to the investigation of the chemokine responsiveness of DC during their development and maturation. These studies have shown that immature and mature DC are not recruited by the same chemokines. Immature DC respond to many CC- and CXC-chemokines (MIP-1alpha, MIP-1beta, MIP-5, MCP-3, MCP-4, RANTES, TECK, and SDF-1) and in particular to MIP-3alpha/LARC, which acts through CCR6, a receptor mainly expressed in DC and lymphocytes. Like most other chemokines acting on immature DC, MIP-3alpha is inducible on inflammatory stimuli. In contrast, mature DC have lost their responsiveness to most of these chemokines through receptor down-regulation or desensitization, but acquired responsiveness to MIP-3beta/ELC and 6Ckine/SLC as a consequence of CCR7 up-regulation. MIP-3alpha mRNA is only detected within inflamed epithelial crypts of tonsils, the site of antigen entry known to be infiltrated by immature DC, whereas MIP-3alpha and 6Ckine are specifically expressed in the T cell-rich areas where mature IDC home. These observations suggest a role for chemokines induced on inflammation such as MIP-3alpha in recruitment of immature DC at the site of injury and a role for MIP-3beta/6Ckine in accumulation of antigen-loaded mature DC in T cell-rich areas of the draining lymph node. A better understanding of the regulation of DC trafficking might offer new opportunities of therapeutic interventions to suppress or stimulate the immune response.