gebhart/patrepeval huggingface dataset:
Reinterpreting the Myers‐Briggs Type Indicator From the Perspective of the Five‐Factor Model of Personality (1989)

The Myers-Briggs Type Indicator (MBTI; Myers & McCaulley, 1985) was evaluated from the perspectives of Jung's theory of psychological types and the five-factor model of personality as measured by self-reports and peer ratings on the NEO Personality Inventory (NEO-PI; Costa & McCrae, 1985b). Data were provided by 267 men and 201 women ages 19 to 93. Consistent with earlier research and evaluations, there was no support for the view that the MBTI measures truly dichotomous preferences or qualitatively distinct types; instead, the instrument measures four relatively independent dimensions. The interpretation of the Judging-Perceiving index was also called into question. The data suggest that Jung's theory is either incorrect or inadequately operationalized by the MBTI and cannot provide a sound basis for interpreting it. However, correlational analyses showed that the four MBTI indices did measure aspects of four of the five major dimensions of normal personality. The five-factor model provides an alternative basis for interpreting MBTI findings within a broader, more commonly shared conceptual framework.
Accurate Breast Contour Detection Algorithms in Digital Mammogram (2011)

Computer Aided Diagnosis (CAD) systems have improved diagnosis of abnormalities in mammogram images. The principal feature within the breast region is the breast contour. Extraction of the breast region and delineation of the breast contour allows the search for abnormalities to be limited to the region of the breast without undue influence from the background of the mammogram. After performing an essential pre-processing step to suppress artifacts and accentuate the breast region, the exact breast region as the region of interest (ROI), has to be segmented. In this paper we present a fully automated segmentation and boundary detection method for mammographic images.
[Monkey B-lymphocyte subpopulations transformed by baboon herpes virus in vivo and in tissue cultures]. (1986)

Baboon herpes virus (BHV) similarly to human Epstein-Barr virus shows tropism to B cell subpopulation. In lymphoblastoid cultures transformed in vitro by BHV no E-RFC (T cells) are found but there are B cells with surface and cytoplasmic immunoglobulins. In a number of cultures IgM could be detected only in the cell cytoplasm. E-RFC are detectable in cultures in early passages but not after 17 passages which may be due to their elimination. The time course of cell-mediated immunity values was studied in Macaca arctoides monkeys inoculated with BHV. An increase in the relative and absolute number of B cells with surface IgM and IgG in the peripheral blood was noted. Two months after inoculation the values returned to the initial level. The number of E-RFC did not change. Changes in the number of B cells may be associated with the development of immune response, or BHV influence on the process of B cell circulation in the host.
Active attack against HB <sup>+</sup> : a provably secure lightweight authentication protocol (2005)

Much research has focused on providing RFID tags with lightweight cryptographic functionality. The HB+ authentication protocol was recently proposed and claimed to be secure against both passive and active attacks. A linear-time active attack against HB+ is proposed.
Carbon number-dependent intercalation and interlayer amidation properties of α,ω-alkanediamines for α-titanium (2-carboxyethyl)phosphonate phosphate (1998)

The uptake of α,ω-alkanediamines H2N(CH2)nNH2 (n = 2–10) by α-titanium (2-carboxyethyl)phosphonate phosphate, Ti(O3PCH2CH2CO2H)1.91(HPO4)0.09, has been studied at 25 °C. Each diamine forms one or two intercalated phases in which the amine molecules are arranged as a monolayer with their axes tilted by 54 or 67° relative to the inorganic layer. Diamines with n 7 show a tendency to produce the high and low chain-tilt forms depending on the even and odd number of carbon atoms, respectively, but both forms coexist for n = 6. For shorter chain diamines, on the other hand, only the low-tilt form occurs for n = 3, 4 and 5 and the high-tilt form for n = 2. On heating at 150 °C or above the diammonium-exchanged solids were thermally condensed into the amide form with or without any significant release of the amine guest. The amidation temperature shows a tendency to vary up or down depending on whether the carbon number is even or odd.
Low voltage electron emission from Pb(Zr/sub x/Ti/sub 1-x/)O/sub 3/-based thin film cathodes (2002)

Electron emission from ferroelectric thin films (/spl les/1 /spl mu/m thick) is demonstrated. In addition, electron energy distributions have been measured using an Auger Electron Spectrometer (AES). The electron emission measurements were performed using ferroelectric cathodes based on thin Pb(Zr/sub 0.53/Ti/sub 0.47/)O/sub 3/ (PZT) films and 80-110 /spl mu/m Pb/sub 0.93/La/sub 0.07/ (Z/sub 0.53/Ti/sub 0.47/)O/sub 3/ (PLZT) layered capacitors with Pt top and bottom electrodes. Current densities in the range of 0.5-1.5 mA/cm/sup 2/ were measured from the PLZT cathodes excited with 100-400 volt pulses, which produced electrons of about 265 eV with a narrow energy distribution (FWHM of about 30 eV). On the other hand, current densities in the range 0.07-0.15 /spl mu/A/cm/sup 2/ were measured for thin film PZT-based cathodes excited with pulses in the range 10-40 volts. The initial results suggest that the electron emission current may depend, among other factors, on the thickness of the ferroelectric layer, the applied excitation voltage, and the interval between the polarizing and switching pulses.
Self driven synchronous rectification in resonant topologies: forward ZVS-MRC, forward ZCS-QRC and LCC-PRC (2003)

Three resonant topologies (LCC-PRC, forward ZCS-QRC and forward ZVS-MRC) with self-driven synchronous rectification are compared from the point of view of telecom applications, taking into account efficiency, simplicity, and switching frequency variation range. It is concluded that it is possible to obtain a very high efficiency even with low output voltage (3.3 V) in any of these topologies with the use of synchronous rectification. However, when there is a high variation range in load and input voltage, the best performance is the one shown by the forward ZVS-MRC. This topology presents the additional advantage of being able to operate at very high switching frequency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Carpacio (2017)

Standard vehicle infotainment systems often include touch screens that allow the driver to control their mobile phone, navigation, audio, and vehicle configurations. For the driver's safety, these interfaces are often disabled or simplified while the car is in motion. Although this reduced functionality aids in reducing distraction for the driver, it also disrupts the usability of infotainment systems for passengers. Current infotainment systems are unaware of the seating position of their user and hence, cannot adapt. We present Carpacio, a system that takes advantage of the capacitive coupling created between the touchscreen and the electrode present in the seat when the user touches the capacitive screen. Using this capacitive coupling phenomenon, a car infotainment system can intelligently distinguish who is interacting with the screen seamlessly, and adjust its user interface accordingly. Manufacturers can easily incorporate Carpacio into vehicles since the included seat occupancy detection sensor or seat heating coils can be used as the seat electrode. We evaluated Carpacio in eight different cars and five mobile devices and found that it correctly detected over 2600 touches with an accuracy of 99.4%.
Structure, magnetic and electronic properties of charge transfer complex containing hexacyanoferrate chain and BEDT-TTF column (2002)

A novel charge transfer complex containing of hexacyanoferrate (Fe(CN) 6 ) unit, which has been exhibited variety of magnetic topics in prussian blue systems, was synthesized. X-ray analysis of the single crystal obtained by electrolysis of BEDT-TTF (ET) and hexacyanoferrate suggests that this complex contains 1D magnetic hexacyanoferrate chain perpendicular to the conducting ET column. This significant structure implies that significant properties can be expected caused by the interaction between the spin momentum on d-electrons and a conducting π-electrons influenced vertically by the applied magnetic field. From the result of the electrical conducting measurement, it is suggested that is a semiconductor with the activation energy and the conductivity at room temperature to be 0.113eV and 0.46S/cm, respectivity. Detailed X-ray analysis suggests that the occupancies of Fe and C elements in the 1D hexacyanoferrate chain are 0.5, that of N element is 1.0.
Variable Coupling Directional Couplers Using Varactor Diodes (2005)

A microstrip variable coupling directional couplers for 4 GHz band have been proposed and tested. By changing the junction capacitances of the varactor diodes, the coupling varies from 4 dB to 20 dB, and the directivity varies from 16 dB to 29 dB. Available frequency range is from 2.7 GHz to 5.3 GHz.
A Data De-duplication Access Framework for Solid State Drives. (2012)

With the rapid development of SSDs (Solid State Drives), traditional hard drives in many applications have been replaced by SSDs. Since SSDs consist of NAND flash memory, the main challenge to SSDs is that NAND flash memory is highly sensitive to write requests. A lot of write requests will cause garbage collection to reclaim free space due to the out-place update characteristic of flash memory. In the paper, we will propose a data de-duplication access framework for SSDs. The objective is to eliminate duplicate data as much as possible and reduce space consumption. According to the experimental results, the proposed framework can efficiently identify duplicate data and decrease a lot of data written, and at the same time, the overhead is also reasonable.
Doping Group IIB Metal Ions into Quantum Dot Shells via the One‐Pot Decomposition of Metal‐Dithiocarbamates (2015)

Almost half of solar energy reaching the Earth is in the infrared, and for solar cells, IR absorbing/emitting quantum dots are highly effective photovoltaic materials. As a possible approach to generating such materials, an investigation into the incorporation of group IIB metal ions during the shelling of II–VI and III–V semiconductor core/shell quantum dots is presented. Quantum dot shells consist of ZnS and an additional metal sulphide, obtained from the decomposition of metal dithiocarbamate single‐source precursors. Resultant quantum dots are characterized and interrogated using transmission electron microscopy, high‐resolution transmission electron microscopy, electron diffraction, time‐of‐flight‐secondary ion mass spectroscopy, X‐ray photoelectron spectroscopy, energy dispersive X‐ray spectroscopy, photoluminescence emission and lifetime spectroscopy, and UV–vis spectroscopy. It is demonstrated that on incorporation of an additional metal sulphide during shelling, photoluminescence properties change dramatically according to the element and indeed, its concentration. Tunable infrared emission is achieved for Hg addition, thus a one‐pot method for the synthesis of infrared emitting quantum dots from visible luminescent cores is hereby developed.
Quality by design approach: Regulatory need (2014)

In this era of competition quality has been given prime magnitude; failure to meet such quality allied goals produces massive shift of company in share of market. In this context pharmaceutical industry is utmost regulated industry as it is governed by authoritative regulatory bodies. “Quality could be planned and most of quality deficit arises in the way process is planned and developed”, this thought of well known quality expert Joseph Moses Juran gives foundation to the concept of quality by design (QbD). USFDA launched a pilot programme in 2005 to permit participating firms a prospect to submit chemistry, manufacturing, and controls (CMC) of NDA information representing application of QbD. Now USFDA is accelerating QbD drive by making warning to generic manufacturers from January 2013. QbD has its perspectives to contribute the drug design, development, and manufacture of high-quality drug products. In the present review basic consideration of the QbD approach, its historical background, and regulatory needs are discussed. In detail explanation of elements of QbD i.e. method intent, design of experiment, and risk assessment is given. Application of QbD to pharmaceutical and biopharmaceutical processes, development and unit operation associated with it are briefly mentioned. Detail account of QbD to analytical technique is explained thoroughly by referencing examples.
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy (2012)

Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. Here, we show that treatment with starvation conditions sensitized yeast cells (Saccharomyces cerevisiae) expressing the oncogene-like RAS2(val19) to oxidative stress and 15 of 17 mammalian cancer cell lines to chemotherapeutic agents. Cycles of starvation were as effective as chemotherapeutic agents in delaying progression of different tumors and increased the effectiveness of these drugs against melanoma, glioma, and breast cancer cells. In mouse models of neuroblastoma, fasting cycles plus chemotherapy drugs--but not either treatment alone--resulted in long-term cancer-free survival. In 4T1 breast cancer cells, short-term starvation resulted in increased phosphorylation of the stress-sensitizing Akt and S6 kinases, increased oxidative stress, caspase-3 cleavage, DNA damage, and apoptosis. These studies suggest that multiple cycles of fasting promote differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy of certain chemotherapy drugs in the treatment of various cancers.
Service Intelligence Oriented Distributed Data Stream Integration (2016)

Software as a service (SaaS) has recently enjoyed much attention as it makes the use of software more convenient and cost-effective. At the same time, the arising of users' expectation for high quality service such as real-time information or functionality provisioning brings about new challenges: to satisfy such (near) real-time requirements, real-time monitoring and effective processing of streaming data is necessary. However, due to the composition structure and multi-instance property of services, service data streams are often distributed, hard to synchronize and aggregate. We tackles these challenges by (1) proposing systematic associate strategies for relating distributed data; (2) introducing a new small window array mechanism for aggregating distributed data; (3) setting window parameters based on the cumulative distribution function (CDF) method; and (4) modeling streaming operators with queuing models for performance evaluation and prediction. Experiments show that our approach has good accuracy, completeness and acceptable performance measurement in processing distributed service data streams.
Methods for Blind Estimation of the Variance of Mixed Noise and Their Performance Analysis (2011)

International audience
[The action of piracetam and its complex with sodium oxybutyrate in the neuropathic pain syndrome]. (1997)

Effects of the pyracetam and its sodium hydroxybutyrate complex were studied on a model of the neuropathic pain syndrome. It was demonstrated that the pyracetam prevents the development of the neuropathic pain syndrome. The pyracetam relieves the pain syndrome. The sodium hydroxybutyrate appears to enhance preventive and medical effects of the pyracetam. Possible mechanisms of action of these drugs are discussed.
Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor (2020)

The histone acetyltransferases, CREB binding protein (CBP) and EP300, are master transcriptional co-regulators that have been implicated in numerous diseases, such as cancer, inflammatory disorders, and neurodegeneration. A novel, highly potent, orally bioavailable EP300/CBP histone acetyltransferase (HAT) inhibitor, CPI-1612 or <b>17</b>, was developed from the lead compound <b>3</b>. Replacement of the indole scaffold of <b>3</b> with the aminopyridine scaffold of <b>17</b> led to improvements in potency, solubility, and bioavailability. These characteristics resulted in a 20-fold lower efficacious dose for <b>17</b> relative to lead <b>3</b> in a JEKO-1 tumor mouse xenograft study.
Qualitative Neuromuscular Monitoring: How to Optimize the Use of a Peripheral Nerve Stimulator to Reduce the Risk of Residual Neuromuscular Blockade (2016)

This review provides recommendations for anesthesia providers who may not yet have quantitative monitoring and sugammadex available and thus are providing care within the limitations of a conventional peripheral nerve stimulator (PNS) and neostigmine. In order to achieve best results, the provider needs to understand the limitations of the PNS. The PNS should be applied properly and early. All overdosing of neuromuscular blocking drugs should be avoided and the intraoperative neuromuscular blockade should be maintained only as deep as necessary. The adductor pollicis is the gold standard site and must be used for the pre-reversal assessment, also when the ulnar nerve and thumb were not accessible intraoperatively. Spontaneous recovery should be maximized and neostigmine should be administered after a TOF count of 4 has been confirmed at the adductor pollicis. Extubation should not occur within 10 min after administration of an appropriate dose of neostigmine.
Pembrolizumab in classical Hodgkin's lymphoma (2016)

Pembrolizumab is a humanized monoclonal antibody directed against programmed cell death protein 1 (PD-1), a key immune-inhibitory molecule expressed on T cells and implicated in CD4+ T-cell exhaustion and tumor immune-escape mechanisms. Classical Hodgkin's lymphoma (cHL) is a unique B-cell malignancy in the sense that malignant Reed-Sternberg (RS) cells represent a small percentage of cells within an extensive immune cell infiltrate. PD-1 ligands are upregulated on RS cells as a consequence of both chromosome 9p24.1 amplification and Epstein-Barr virus infection and by interacting with PD-1 promote an immune-suppressive effect. By augmenting antitumor immune response, pembrolizumab and nivolumab, another monoclonal antibody against PD-1, have shown significant activity in patients with relapsed/refractory cHL as well as an acceptable toxicity profile with immune-related adverse events that are generally manageable. In this review, we explore the rationale for targeting PD-1 in cHL, review the clinical trial results supporting the use of checkpoint inhibitors in this disease, and present future directions for investigation in which this approach may be used.
Activation-dependent tyrosine phosphorylation of Fyn-associated proteins in T lymphocytes. (1994)

While previous studies have implicated the tyrosine protein kinase p60fyn in antigenic activation of T lymphocytes, it is clear that signal transduction initiated through the antigen receptor requires the concerted actions of several proteins. Here, we report our finding that the activation of p60fyn following TcR cross-linking results in the tyrosine phosphorylation of two Fyn-associated proteins of 82 and 116 kDa. In the cells analyzed, p116 appears to represent one of the major substrates of T-cell antigen receptor-mediated tyrosine phosphorylation. In activated T-cells, the interaction of these proteins is specific for p60fyn since neither p56lck nor p62c-yes were found to detectably associate with p82 or p116. Furthermore, the p60fyn-p82/p116 complex could be dissociated and then reconstituted in vitro using purified recombinant Fyn. Using this technique we demonstrated that both p82 and p116 were capable of binding to the Fyn SH2 domain while p82 was to some extent capable of independent binding to the Fyn SH3 domain. An association between p60fyn and phosphoproteins possibly related to the T-cell p82 and p116 was also observed in other hematopoietic cells. Thus, the activation-induced phosphorylation of the p60fyn-associated proteins p116 and p82 and the wide distribution of potentially similar p60fyn-associated proteins in hematopoietic cells suggest that p116 and p82 may play a role as physiological substrates and/or regulators of p60fyn.
Phosphinic Peptide Matrix Metalloproteinase-9 Inhibitors by Solid-Phase Synthesis Using a Building Block Approach (1999)

Substrates of matrix metalloproteinase-9 (MMP-9) having Gly and Leu in the P1 and P1′ position can be converted into highly potent inhibitors by incorporation of a phosphinic -GΨ{P(O)OHCH2}L- moiety (see figure). This was shown for an array of phosphinic peptide inhibitors which were prepared by solid-phase peptide synthesis using a building block to introduce the phosphinic moiety.
Isolation and mapping of a polymorphic DNA sequence cEFD52 on chromosome 17q [D17S26] (1988)

Journal Article Isolation and mapping of a polymorphic DNA sequence cEFD52 on chromosome 17q [D17S26] Get access Y. Nakamura, Y. Nakamura The Howard Hughes Medical Institute, University of Utah Medical SchoolSalt Lake City, UT 84132, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Fujimoto, E. Fujimoto The Howard Hughes Medical Institute, University of Utah Medical SchoolSalt Lake City, UT 84132, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar P. O'Connell, P. O'Connell The Howard Hughes Medical Institute, University of Utah Medical SchoolSalt Lake City, UT 84132, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Leppert, M. Leppert The Howard Hughes Medical Institute, University of Utah Medical SchoolSalt Lake City, UT 84132, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar G.M. Lathrop, G.M. Lathrop The Howard Hughes Medical Institute, University of Utah Medical SchoolSalt Lake City, UT 84132, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar J.-M. Lalouel, J.-M. Lalouel The Howard Hughes Medical Institute, University of Utah Medical SchoolSalt Lake City, UT 84132, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar R. White R. White The Howard Hughes Medical Institute, University of Utah Medical SchoolSalt Lake City, UT 84132, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 2, 25 January 1988, Page 786, https://doi.org/10.1093/nar/16.2.786 Published: 25 January 1988
Novel open‐chain and cyclic conformationally constrained (<i>R</i>)‐ and (<i>S</i>)‐α,α‐disubstituted tyrosine analogues (1995)

Abstract A series of novel open‐chain and cyclic conformationally constrained ( R )‐ and ( S )‐α,α‐disubstituted tyrosine analogues 1a–e were synthesized in good yields and high optical purities ( Schemes 1 and 2 ). The absolute configurations of these tyrosine analogues were unambiguously determined based on the X‐ray structures of the precursor diastereoisomeric peptides of type 4 and 5 . Four of these structures are described ( Figs. 1–4 ), showing β‐turn type‐I geometries for dipeptides 4a, 5b , and 4c and an extended conformation for peptide 5c ( Table 3 ). The conversion of the free amino acids 1a–c into suitably protected building blocks 11a–d and 15d,e for peptide synthesis is discussed ( Schemes 3 and 4 ).