gebhart/patrepeval huggingface dataset:
Endohedral and Exohedral Complexes of T<sub>8</sub>-Polyhedral Oligomeric Silsesquioxane (POSS) with Transition Metal Atoms and Ions (2008)

The equilibrium geometries of the exohedral and endohedral complexes of the polyhedral oligomeric silsesquioxane (POSS) cage (HSiO3/2)8 containing the transition metal atoms or ions Sc0,+, Cr0,+, Fe0,+, Co0,+, Ni0,+, Cu0,+, Zn0,+, Mo0,+, W0,+, Ru0,+, Os0,+ have been investigated at the B3LYP/LanL2DZ levels. All these species form endohedral complexes with the T8-POSS cage except Sc0,+, Mo0, and W0,+. The Mo0 and W0,+ species as well as Cr0,+, Fe0,+, Co0,+, Ni0,+, Cu+, Zn+, Ru0,+, Os0 form stable exohedral complexes. Geometries, electronic properties and ionization potentials were computed. The Si−O and Si−H bond lengths in the cationic endohedral complexes are shorter than in the corresponding complexes of neutral transition metal atoms. The zero-point corrected inclusion energies of the endohedral species X@(SiHO3/2)8 (X = Fe+, Co+, Ni+, Cu+, Os+) are all negative, suggesting that these complexes are more stable than their isolated components. All exohedral complexes have energies that are lower than their corresponding endohedral analogs. Transition metal atom encapsulation raised the HOMO and lowered the LUMO energies, reducing the HOMO−LUMO gaps of every complex compared to that of the pure cage. The HOMO−LUMO gap of the empty cage is 8.1 eV while the endohedral complexes exhibit gaps between 1.2 and 4.96 eV. Insertion of Cr, Fe, Co, Ni, Cu, or Zn into the POSS cage is more favorable in water than in the gas phase. However, insertion of Co+, Ni+, Cu+, or Zn+ into the POSS cage is less favorable in water than in the gas phase. Overall, both the neutral and ionic endohedral transition metal complexes, X@(SiHO3/2)10, (X = Cr0,+, Fe0,+, Co0,+, Ni0,+, Cu0,+, Zn0,+, Ru0,+, Os0,+) appear to be viable synthetic targets.
Improved JPEG compression algorithm based on saliency maps (2012)

JPEG compression algorithm plays an important role in modern image storage and transmission field. This paper proposes an improved JPEG compression algorithm combined with saliency maps in quantization. It can realize layered compression based on users' attention degree of image content and improve compression ratio on the premise of ensuring the quality of regions where users pay attention. This paper firstly analyzes and realizes of the algorithm based on saliency map. After that, it demonstrates the algorithm's reliability and effectiveness by experiments with different kinds of images. At last, threshold control, which may further improve compression efficiency, is discussed briefly.
Key Factors for Formation of N<sub>2</sub> from Low-Rank Coals during Fixed Bed Pyrolysis:  Pyrolysis Conditions and Inherent Minerals (1997)

Low-rank coals have been pyrolyzed in high-purity He under different conditions with a fixed bed reactor, and factors controlling N2 formation have been examined. N2 is the dominant product at ≥800 °C after almost complete release of tar-N, HCN, and NH3. Heating rate (10−1400 °C/min) affects N2 slightly. In contrast, conversion of coal-N to N2 increases remarkably with increasing temperature with a corresponding decrease in char-N and reaches 65−70% at 1200 °C. These data lead to a strong, reverse correlation between N2 and char-N, which shows that char-N and/or precursors are the major source of N2. Demineralization removes mainly Fe- and Ca-containing minerals and results in a drastic decrease in conversion to N2. Addition of a nanophase iron catalyst after demineralization promotes N2 formation, whereas Ca(OH)2 has no significant effect on it. Upon pyrolysis, Fe-containing minerals probably in the ion-exchangeable forms are transformed into fine particles of metallic iron, which are responsible for the remarkable formation of N2 from low-rank coals. Catalysis by the mineral-derived iron is discussed in terms of interactions with char-N in the solid phase.
Assessing the Pathogenicity of Insertion and Deletion Variants with the Variant Effect Scoring Tool (VEST‐Indel) (2015)

Insertion/deletion variants (indels) alter protein sequence and length, yet are highly prevalent in healthy populations, presenting a challenge to bioinformatics classifiers. Commonly used features--DNA and protein sequence conservation, indel length, and occurrence in repeat regions--are useful for inference of protein damage. However, these features can cause false positives when predicting the impact of indels on disease. Existing methods for indel classification suffer from low specificities, severely limiting clinical utility. Here, we further develop our variant effect scoring tool (VEST) to include the classification of in-frame and frameshift indels (VEST-indel) as pathogenic or benign. We apply 24 features, including a new "PubMed" feature, to estimate a gene's importance in human disease. When compared with four existing indel classifiers, our method achieves a drastically reduced false-positive rate, improving specificity by as much as 90%. This approach of estimating gene importance might be generally applicable to missense and other bioinformatics pathogenicity predictors, which often fail to achieve high specificity. Finally, we tested all possible meta-predictors that can be obtained from combining the four different indel classifiers using Boolean conjunctions and disjunctions, and derived a meta-predictor with improved performance over any individual method.
User Preferences Modeling and Learning for Pleasing Photo Collage Generation (2015)

In this paper we consider how to automatically create pleasing photo collages created by placing a set of images on a limited canvas area. The task is formulated as an optimization problem. Differently from existing state-of-the-art approaches, we here exploit subjective experiments to model and learn pleasantness from user preferences. To this end, we design an experimental framework for the identification of the criteria that need to be taken into account to generate a pleasing photo collage. Five different thematic photo datasets are used to create collages using state-of-the-art criteria. A first subjective experiment where several subjects evaluated the collages, emphasizes that different criteria are involved in the subjective definition of pleasantness. We then identify new global and local criteria and design algorithms to quantify them. The relative importance of these criteria are automatically learned by exploiting the user preferences, and new collages are generated. To validate our framework, we performed several psycho-visual experiments involving different users. The results shows that the proposed framework allows to learn a novel computational model which effectively encodes an inter-user definition of pleasantness. The learned definition of pleasantness generalizes well to new photo datasets of different themes and sizes not used in the learning. Moreover, compared with two state of the art approaches, the collages created using our framework are preferred by the majority of the users.
Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth? (1999)

The survival of microencapsulated islet grafts is limited, even if capsular overgrowth is restricted to a small percentage of the capsules. In search of processes other than overgrowth contributing to graft failure, we have studied the islets in non-overgrown capsules at several time points after allotransplantation in the rat. All recipients of islet allografts became normoglycemic. Grafts were retrieved at 4 and 8 weeks after implantation and at 15.3 +/- 2.3 weeks postimplant, 2 weeks after the mean time period at which graft failure occurred. Overgrowth of capsules was complete within 4 weeks postimplant, and it was usually restricted to <10% of the capsules. During the first 4 weeks of implantation, 40% of the initial number of islets was lost. Thereafter, we observed a decrease in function rather than in numbers of islets, as illustrated by a decline in the ex vivo glucose-induced insulin response. At 4 and 8 weeks postimplant, beta-cell replication was 10-fold higher in encapsulated islets than in islets in the normal pancreas, but these high replication rates were insufficient to prevent a progressive increase in the percentage of nonviable tissue in the islets. Necrosis and not apoptosis proved to be the major cause of cell death in the islets. The necrosis mainly occurred in the center of the islets, which indicates insufficient nutrition as a major causative factor. Our study demonstrates that not only capsular overgrowth but also an imbalance between beta-cell birth and beta-cell death contributes to the failure of encapsulated islet grafts. Our observations indicate that we should focus on finding or creating a transplantation site that, more than the unmodified peritoneal cavity, permits for close contact between the blood and the encapsulated islet tissue.
Manganese acquisition is essential for virulence of Enterococcus faecalis (2018)

Manganese (Mn) is an essential micronutrient that is not readily available to pathogens during infection due to an active host defense mechanism known as nutritional immunity. To overcome this nutrient restriction, bacteria utilize high-affinity transporters that allow them to compete with host metal-binding proteins. Despite the established role of Mn in bacterial pathogenesis, little is known about the relevance of Mn in the pathophysiology of E. faecalis. Here, we identified and characterized the major Mn acquisition systems of E. faecalis. We discovered that the ABC-type permease EfaCBA and two Nramp-type transporters, named MntH1 and MntH2, work collectively to promote cell growth under Mn-restricted conditions. The simultaneous inactivation of EfaCBA, MntH1 and MntH2 (ΔefaΔmntH1ΔmntH2 strain) led to drastic reductions (>95%) in cellular Mn content, severe growth defects in body fluids (serum and urine) ex vivo, significant loss of virulence in Galleria mellonella, and virtually complete loss of virulence in rabbit endocarditis and murine catheter-associated urinary tract infection (CAUTI) models. Despite the functional redundancy of EfaCBA, MntH1 and MntH2 under in vitro or ex vivo conditions and in the invertebrate model, dual inactivation of efaCBA and mntH2 (ΔefaΔmntH2 strain) was sufficient to prompt maximal sensitivity to calprotectin, a Mn- and Zn-chelating host antimicrobial protein, and for the loss of virulence in mammalian models. Interestingly, EfaCBA appears to play a prominent role during systemic infection, whereas MntH2 was more important during CAUTI. The different roles of EfaCBA and MntH2 in these sites could be attributed, at least in part, to the differential expression of efaA and mntH2 in cells isolated from hearts or from bladders. Collectively, this study demonstrates that Mn acquisition is essential for the pathogenesis of E. faecalis and validates Mn uptake systems as promising targets for the development of new antimicrobials.
Purification and characterization of a novel thermostable <i>β</i>-amylase from <i>Clostridium thermosulphurogenes</i> (1988)

An extracellular beta-amylase from Clostridium thermosulphurogenes was purified 811-fold to homogeneity, and its general molecular, physico-chemical and catalytic properties were determined. The native enzyme was a tetramer of 210 kDa composed of a single type subunit; its 20 amino acid N-terminus displayed 45% homology with Bacillus polymyxa beta-amylase. The beta-amylase was enriched in both acidic and hydrophobic amino acids. The pure enzyme displayed an isoelectric point of 5.1 and a pH activity optimum of 5.5. The optimum temperature for beta-amylase activity was 75 degrees C, and enzyme thermostability at 80 degrees C was enhanced by substrate and Ca2+ addition. The beta-amylase hydrolysed amylose to maltose and amylopectin and glycogen to maltose and limit dextrins, and it was inhibited by alpha- and beta-cyclodextrins. The enzyme displayed kcat. and Km values for boiled soluble starch of 400,000 min-1 per mol and 1.68 mg/ml, respectively. The enzyme was antigenically distinct from plant beta-amylases.
Changes in the Surface of Virus‐Infected Cells Recognized by Cytotoxic T Cells (1976)

P-815 mastocytoma cells developed susceptibility to immune T-cell-mediated cytolysis shortly after infection by ectromelia virus. Intracellular viral replication and late protein synthesis seem to bu unnecessary events. Interference with early protein synthesis, however, inhibits the development of susceptibility to lysis. The important intracellular events necessary for subsequent cytolysis appear to occur within 1 hour of infection. Virus rendered non-infectious by ultraviolet irradiation but not by gamma irradiation is able to induce these changes. By determining the minimum and essential events of the infectious process which result in T-cell-mediated cytolysis, the task of establishing the molecular changes occurring in the target cell surface membrane necessary for immune T-cell recognition should be simplified.
FPGA-based CNN inference accelerator synthesized from multi-threaded C software (2017)

A deep-learning inference accelerator is synthesized from a C-language software program parallelized with Pthreads. The software implementation uses the well-known producer/consumer model with parallel threads interconnected by FIFO queues. The LegUp high-level synthesis (HLS) [1] tool synthesizes threads into parallel FPGA hardware, translating software parallelism into spatial parallelism. A complete system is generated where convolution, pooling and padding are realized in the synthesized accelerator, with remaining tasks executing on an embedded ARM processor. The accelerator incorporates reduced precision, and a novel approach for zero-weight-skipping in convolution. On a mid-sized Intel Arria 10 SoC FPGA, peak performance on VGG-16 is 138 effective GOPS.
Subsurface Structure Analysis Using Computational Interpretation and Learning: A Visual Signal Processing Perspective (2018)

Understanding Earth's subsurface structures has been and continues to be an essential component of various applications such as environmental monitoring, carbon sequestration, and oil and gas exploration. By viewing the seismic volumes that are generated through the processing of recorded seismic traces, researchers were able to learn from applying advanced image processing and computer vision algorithms to effectively analyze and understand Earth's subsurface structures. In this article, we first summarize the recent advances in this direction that relied heavily on the fields of image processing and computer vision. Second, we discuss the challenges in seismic interpretation and provide insights and some directions to address such challenges using emerging machine-learning algorithms.
Efficacy of erbium glass laser in the treatment of Old World cutaneous leishmaniasis: A case series (2018)

Erbium glass fractional laser may be an alternative treatment for localized cases of Old World cutaneous leishmaniasis.
Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity (2002)

DNA polymerase fidelity or specificity expresses the ability of a polymerase to select a correct nucleoside triphosphate (dNTP) from a pool of structurally similar molecules. Fidelity is quantified from the ratio of specificity constants (catalytic efficiencies) for alternate substrates (i.e. correct and incorrect dNTPs). An analysis of the efficiency of dNTP (correct and incorrect) insertion for a low fidelity mutant of DNA polymerase beta (R283A) and exonuclease-deficient DNA polymerases from five families derived from a variety of biological sources reveals that a strong correlation exists between the ability to synthesize DNA and the probability that the polymerase will make a mistake (i.e. base substitution error). Unexpectedly, this analysis indicates that the difference between low and high fidelity DNA polymerases is related to the efficiency of correct, but not incorrect, nucleotide insertion. In contrast to the loss of fidelity observed with the catalytically inefficient R283A mutant, the fidelity of another inefficient mutant of DNA polymerase beta (G274P) is not altered. Thus, although all natural low fidelity DNA polymerases are inefficient, not every inefficient DNA polymerase has low fidelity. Low fidelity polymerases appear to be an evolutionary solution to how to replicate damaged DNA or DNA repair intermediates without burdening the genome with excessive polymerase-initiated errors.
"Dry-to-the-touch" thermal grease (2002)

Most thermal engineers believe that thermal greases (or heat sink compounds) provide the lowest thermal resistance of all thermal interface materials. Micro-faze/sup (R)/ is a proprietary design, dry-to-the-touch thermal grease product that offers the lowest thermal resistance at low closure force, thus eliminating the need to sacrifice thermal performance for convenience. This dry grease is totally adaptable to die-cut and possesses a natural tackiness that allows it to adhere to a component or heat sink without using adhesives that degrade thermal performance. The material also exhibits a positive CTE and its thixotropic properties allow it to wet surfaces, further improving interface contact. It is electrically insulating in one version. It is silicone-free in both versions so that contamination problems are avoided. With thermal management becoming ever more complex, engineers must measure the convenience of silicone elastomer thermal pads and more recent wax-based phase-change materials against the superior performance demonstrated by thermal grease. Although easy to use, thermal pads still show a relatively high thermal resistance; phase-change materials may perform better, yet bear limitations in performance. While grease offers superior performance, it can be messy and difficult to handle, thereby becoming labor intensive, making these considerations key factors in the rationale for product development. This paper describes a new thermal interface material that uses all of the advantages of grease replacements, with the lowest thermal resistance of actual thermal grease.
Efficacy of immune therapy in early experimental Naegleria fowleri meningitis (1987)

Naegleria fowleri meningoencephalitis is usually fatal in humans despite treatment. As a new approach, we tested intracisternal passive immune therapy in rabbits with amebic meningoencephalitis by using antinaegleria immune serum, an immunoglobulin G fraction, and a newly developed monoclonal antibody to N. fowleri. Both the immune serum and an immunoglobulin G fraction isolated from it by affinity chromatography provided a consistent, although temporary, protective effect, shown by prolongation of survival (P = 0.001). Multiple doses of immune serum further prolonged survival (P = 0.005). The protective effect of serum was retained after heating to 56 degrees C. We then developed a monoclonal antibody to N. fowleri which provided similar protection. Passive intracisternal antibody therapy might serve as an adjunctive component in the treatment of amebic meningoencephalitis.
Strange attractors in weakly turbulent Couette-Taylor flow (1987)

We have conducted an experiment on the transition from quasiperiodic to weakly turbulent flow of a fluid contained between concentric cylinders with the inner cylinder rotating and the outer cylinder at rest. Power spectra, phase-space portraits, and circle maps obtained from velocity time-series data indicate that the nonperiodic behavior which we have observed is deterministic, that is, it is described by strange attractors. We discuss various problems that arise in computing the dimension of strange attractors constructed from experimental data and show that these problems impose severe requirements on the quantity and accuracy of data necessary for determining dimensions greater than about 5. In the present experiment the attractor dimension increases from 2 at the onset of turbulence to about 4 at a Reynolds number 50% above the onset of turbulence.
Viscometric investigation of aggregate formation in dilute conjugated polymer solutions (2005)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Chi C. Hua, Chien L. Chen, Chi W. Chang, Cheng K. Lee, Show A. Chen; Viscometric investigation of aggregate formation in dilute conjugated polymer solutions. J. Rheol. 1 May 2005; 49 (3): 641–656. https://doi.org/10.1122/1.1879040 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
Coreless Transmitting Coils With Conductive Magnetic Shield for Wide-Range Ubiquitous IPT (2018)

New coreless transmitting (Tx) coils with a conductive material plate for wide-range ubiquitous inductive power transfer (IPT) zones, i.e., U-IPT zones, where electric devices can be wirelessly charged during operation, are proposed in this paper. Because commercialized IPT systems are only available for short distances of several centimeters and one-to-one charging, the demand is increasing for U-IPT zones in which long-distance wireless charging with three-dimensional (3-D) free-positioning and simultaneous charging of multiple receiving (Rx) coils can be achieved. To satisfy this demand, U-IPT zones should be constructed to have a uniform magnetic field distribution in a wide space, which also poses no risk to the human body. In addition, to generate a uniform magnetic field in a wide 3-D space, such as a single room, the system requires the installation of many Tx coils above the ceilings and behind the walls of the room, and these coils should be capable of high electrical performance to support the efficiency of the entire IPT system and should be of excellent mechanical quality. Therefore, a U-IPT zone should meet the following four criteria: human safety, free-positioning of Rx coils, magnetic field uniformity, and economization. By virtue of a conductive material plate that cancels out the undesired direction of magnetic flux generated from the return wires, the proposed coreless Tx coil does not need any heavy ferromagnetic cores, which can cause nonuniformity of the magnetic field distribution and difficult construction. A prototype coreless Tx coil with the dimensions of 1 m × 1 m × 10 cm was fabricated and experimentally verified for a 1 m × 1 m U-IPT zone. The experimental results showed that 74%, 83%, and 76% high magnetic field uniformity could be achieved for z <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> = 25 cm, 50 cm, and 75 cm, respectively, and a 3-D omnidirectional wireless power delivery was achieved, while the guideline of the International Commission on Non-Ionizing Radiation Protection for human safety was satisfied throughout the entire U-IPT zone. Moreover, the weight of the entire system was only 9 kg, enabling easy installation. In the multiple wireless charging experiments, 47 W of power was consumed in total by load resistors, each of them connected to nine Rx coils, respectively, with 32% power efficiency at z <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> = 20 cm.