gebhart/patrepeval huggingface dataset:
On the safety of repeated ketamine infusions for the treatment of depression: Effects of sex and developmental periods (2018)

In this review, we will discuss the safety of repeated treatments with ketamine for patients with treatment-resistant depression (TRD), a condition in which patients with major depression do not show any clinical improvements following treatments with at least two antidepressant drugs. We will discuss the effects of these treatments in both sexes at different developmental periods. Numerous small clinical studies have shown that a single, low-dose ketamine infusion can rapidly alleviate depressive symptoms and thoughts of suicidality in patients with TRD, and these effects can last for about one week. Interestingly, the antidepressant effects of ketamine can be prolonged with intermittent, repeated infusion regimens and produce more robust therapeutic effects when compared to a single infusion. The safety of such repeated treatments with ketamine has not been thoroughly investigated. Although more studies are needed, some clinical and preclinical reports indicated that repeated infusions of low doses of ketamine may have addictive properties, and suggested that adolescent and adult female subjects may be more sensitive to ketamine's addictive effects. Additionally, during ketamine infusions, many TRD patients report hallucinations and feelings of dissociation and depersonalization, and therefore the effects of repeated treatments of ketamine on cognition must be further examined. Some clinical reports indicated that, compared to women, men are more sensitive to the psychomimetic effects of ketamine. Preclinical studies extended these findings to both adolescent and adult male rodents and showed that male rodents at both developmental periods are more sensitive to ketamine's cognitive-altering effects. Accordingly, in this review we shall focus our discussion on the potential addictive and cognitive-impairing effects of repeated ketamine infusions in both sexes at two important developmental periods: adolescence and adulthood. Although more work about the safety of ketamine is warranted, we hope this review will bring some answers about the safety of treating TRD with repeated ketamine infusions.
Fast 3D profilometer based upon the projection of a single fringe pattern and absolute calibration (2006)

We present a whole-field, 3D optical digitizer based on phase profilometry and on absolute calibration, which performs shape measurement through the projection of a single pattern of Ronchi fringes, and an absolute calibration of the optical head. A suitably developed procedure, based on accurate fringe analysis, implements phase extraction and allows univocal indexing of the field of view. Accurate models express, in a global reference system, both extrinsic and intrinsic parameters of the camera–projector pair. Proper calibration is performed for lens distortion compensation, and to obtain the absolute measurement of the shapes within a global reference system. The technique requires the acquisition of a single image, shows good robustness against fine variations of the fringe period and adapts well to the measurement of free-form shapes in a very short time. The system is portable, fully reconfigurable depending on the measurement requirements and suitable for a low-cost implementation. In this paper, we present the phase extraction method and the system calibration, and highlight the measurement performance of the digitizer in different set-ups, using free-form objects requiring multi-view acquisition.
EUTRAN Uplink Performance (2007)

Alongside with on-going further WCDMA development, work on evolved universal terrestrial radio access network (EUTRAN), also known as long term evolution (LTE), has been initiated in 3GPP. The objective of EUTRAN is to develop a framework for the evolution of the 3GPP radio-access technology towards wider bandwidth, lower latency and packet-optimized radio-access technology with peak data rate capability up to 100 Mbps. For the uplink direction, single carrier-FDMA (SC-FDMA) has been chosen as the multiple access technology. This paper introduces the uplink technology, the current state of progress in 3GPP as well as expected schedule for actual specification availability and describes a couple of key features, channel dependent frequency domain scheduling and multi-user MIMO in more detail. System performance results for channel dependent frequency domain scheduling are presented as well
Trench shielded gate concept for improved switching performance with the low miller capacitance (2016)

This paper presents the new gate structure concept in trench gate IGBTs in order to have extended performance in faster switching without penalties on the on-state voltage drop (Von). The combination of the trench gate and adjacent emitter-connected trench achieves the dramatic Miller capacitance reduction while maintaining the enough Injection Enhancement (IE) effect. The experimental demonstration achieved as much as 37% of reduction in the total switching loss.
Effect of precursors on propagation loss for plasma-enhanced chemical vapor deposition of SiN_x:H waveguides (2016)

This work investigates the role of precursor gas chemistry, SiH4/NH3/N2, on hydrogen incorporation into PECVD H:SiNx for optical applications. The largest reduction in of N-H bond density is shown to respond from SiH4 flow, indicating that all precursor gases must be optimized for low loss waveguides. A linear correlation of N-H bond density with propagation losses in SiNx waveguides is observed, allowing for a propagation loss to be estimated by N-H bond density without waveguide fabrication. With proper optimization of process parameters, we are able to obtain propagation losses as low as −1.6 dB/cm at 1550 nm without a thermal anneal.
A Conserved Transcription Motif Suggesting Functional Parallels between Caenorhabditis elegans SKN-1 and Cap'n'Collar-related Basic Leucine Zipper Proteins (2000)

In Caenorhabditis elegans, the predicted transcription factor SKN-1 is required for embryonic endodermal and mesodermal specification and for maintaining differentiated intestinal cells post-embryonically. The SKN-1 DNA-binding region is related to the Cap'n'Collar (CNC) family of basic leucine zipper proteins, but uniquely, SKN-1 binds DNA as a monomer. CNC proteins are absent in C. elegans, however; and their involvement in the endoderm and mesoderm suggests some functional parallels to SKN-1. Using a cell culture assay, we show that SKN-1 induces transcription and contains three potent activation domains. The functional core of one domain is a short motif, the DIDLID element, which is highly conserved in a subgroup of vertebrate CNC proteins. The DIDLID element is important for SKN-1-driven transcription, suggesting a likely significance in other CNC proteins. SKN-1 binds to and activates transcription through the p300/cAMP-responsive element-binding protein-binding protein (CBP) coactivator, supporting the genetic prediction that SKN-1 recruits the C. elegans p300/CBP ortholog, CBP-1. The DIDLID element appears to act independently of p300/CBP, however, suggesting a distinct conserved target. The evolutionarily preservation of the DIDLID transcriptional element supports the model that SKN-1 and some CNC proteins interact with analogous cofactors and may have preserved some similar functions despite having divergent DNA-binding domains.
NF-κB Signaling, Elastase Localization, and Phagocytosis Differ in HIV-1 Permissive and Nonpermissive U937 Clones (2008)

To identify positive or negative factors for HIV-1 infectivity, clones from the U937 promonocytic cell line that express similar levels of CD4 and CXCR4, but differ in HIV-1 susceptibility, were compared. In contrast to HIV-1 permissive clone 10 (plus), nonpermissive clone 17 (minus) was adherent to coverslips coated with chemokines, was phagocytic, killed bacteria, and expressed human leukocyte elastase (HLE) in a granule-like compartment (HLEG) that was never detected at the cell surface (HLECS). In contrast to the minus clone, the plus clone expressed HLE on the cell surface and was adherent to coverslips coated with the HLECS ligands alpha1proteinase inhibitor (alpha1PI, alpha1antitrypsin) and the HIV-1 fusion peptide. The phosphorylation status of several important signaling proteins was studied at the single cell level. Tumor suppressor p53, NF-kappaB p65, and Akt were constitutively phosphorylated in the plus clone, but not in the minus clone. Surprisingly, both alpha1PI and LPS induced phosphorylation of NF-kappaB p65 Ser-536 in both clones, but induced dephosphorylation of Ser-529 in the plus clone only. HIV-1 permissivity was conferred to the minus clone in a manner that required stimulation by both alpha1PI and LPS and was coincident to NF-kappaB p65 phosphorylation/dephosphorylation events as well as translocation of HLE to the cell surface. Even when stimulated, the minus clone exhibited greater reverse transcriptase activity, but less p24, than the plus clone. Results presented suggest that HIV-1 uptake and production efficiency are influenced by signaling profiles, receptor distribution, and the phagocytic capacity specific to the stage of differentiation of the CD4+ target cell.
Intrapartum Exposure to Nevirapine and Subsequent Maternal Responses to Nevirapine-Based Antiretroviral Therapy (2004)

Women who received intrapartum nevirapine were less likely to have virologic suppression after six months of postpartum treatment with a nevirapine-containing regimen. Our data suggest the need for strategies to maximize the benefits of both antiretroviral prophylaxis against mother-to-child transmission of HIV and antiretroviral therapy for mothers.
GaAs Fet Ultrabroad-Band Amplifiers for Gbit/s Data Rate Systems (1981)

A novel ultrabroad-band amplifier configuration suitable for GaAs FET's has been developed. The developed amplifier circuit operates as a capacitor-resistor ( C-R ) coupled mnpfifier circuit in the low-frequency range in which |S/sub 21/| for the GaAs FET's is constant. It also operates as a lossless impedance matching circuit in the microwave frequency range in which |S/sub 21/| for the GaAs FET has a slop of approximately -6 dB/octave. Using this configuration technique, 800-kHz 9.5-GHz band (13.5 octaves), 8.6-dB gain GaAs FET amplifier modules have been realized. The amplifier module has 40-ps step response rise time. It also has low input and output VSWR. By cascading two-amplifier modules, 19-dB gain over the 800-kHz to 8.5-GHz range and 50-ps step response rise time were obtained. NF is lower than 8 dB over the 50-MHz to 6-GHz range.
Comparison and Analysis of Laparoscopic Intracorporeal Suturing Devices: Preliminary Results (2001)

Preliminary results show that each of the laparoscopic suturing devices has distinct advantages over conventional intracorporeal suturing and tying. Decreased times and comparable, if not greater, knot strengths may translate into improved laparoscopic suturing/tying performance for laparoscopic intracorporeal suturing devices.
Teacher-Supervised Generative Adversarial Networks (2021)

Although generative adversarial networks (GANs) show impressive effects on image generation, existing GANs suffer an unstable training process, and thus result in poor image quality sometimes. To solve this problem, we first introduce a supervision mechanism into GANs and propose a teacher-supervised GAN (GAN-T) model. Specifically, we design a teacher supervision mechanism to inspect whether the features of generated images are as real as those of real images. If not, we add action into the generator. The action takes the encoding of the real image as prior knowledge to guide the generation of samples. We then apply our proposed method to existing GANs to show its compatibility with them. Finally, we conduct extensive experiments on the tasks of noise-to-image generation and image translation, and experimental results show that our proposed method can significantly stabilize the training process of the generator and improve the quality of generated images.
A pointer location algorithm for computer visionbased automatic reading recognition of pointer gauges (2019)

Abstract In order to implement a computer vision based reading recognition system for pointer gauges, we propose an algorithm to locate the pointer by searching for the minimal bounding rectangle (MBR) of the pointer region. Having determined the center of dial region and the centroids of scale marks, we build up a reference system for reading recognition with the dial region center and the scale mark centroids. To identify the indicating value of a gauge image, we first detect the pointer region based on frame difference, and determine the MBR of the pointer using the longest edge of its convex hull. We then take the centroid of the MBR enclosing the pointer region as the centroid of the pointer. We next take the connection between the pointer centroid to the dial center as the pointer, and calculate the indicating value corresponding to the pointer based on the angle method. Experimental results reveal the effectiveness of the pointer location algorithm in computer vision based reading recognition for pointer gauges.
New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers (2009)

The main retinol carriers in the cytosol are the cellular retinol-binding proteins types I and II (CRBP-I and CRBP-II), which exhibit distinct tissue distributions. They play different roles in the maintenance of vitamin A homeostasis and feature a 100-fold difference in retinol affinity whose origin has not been described in detail. NMR-based hydrogen/deuterium exchange measurements show that, while retinol binding endows both proteins with a more rigid structure, many amide protons exchange much faster in CRBP-II than in CRBP-I in both apo and holo form, despite the conserved three-dimensional fold. The remarkable difference in intrinsic stability between the two homologs appears to modulate their binding properties: the stronger retinol binder CRBP-I displays a reduced flexibility of the backbone structure with respect to CRBP-II. This difference must derive from specific evolution-based amino acid substitutions, resulting in additional stabilization of the CRBP-I scaffold: in fact, we identified a number of potential salt bridges on the protein surface as well as several key interactions inside the binding cavity. Furthermore, our NMR data demonstrate that helix alphaII of the characteristic helix-turn-helix motif in the ligand portal region exists in both apo and holo CRBP-II. Hence, the previously proposed model of retinol binding needs to be revised.
Fabrication and performances of AI/CuO nano composite films for ignition application (2015)

In an effort to explore the application possibility of composite films in ignition field, Al/CuO was fabricated on semiconductor bridge (SCB) chip by ion beam sputtering technique. Surface morphology and elemental composition of the composite films were analysed by scanning electron microscope (SEM) and energy dispersive spectrometer (EDS). Spatial size and duration of the products was detected with the open-air combustion experiment. The results showed that the prepared composite films surface is smooth, flat, and uniform. Element weight ratio meets the design requirements. And the chemical reaction of the Al/CuO nCFs improves output performances of ignition chip.
The British Comparative Thromboplastin: the Relationship between Lipid Class Composition and Procoagulant Activity (1980)

Twenty-eight consecutive batches of the reference reagent British Comparative Thromboplastin (BCT) were produced in the National (UK) Reference Laboratory for Anticoagulant Reagents and Control (NRLARC) between 1969 and 1977. The relationship between procoagulant activity and lipid class composition in these batches at various stages of age deterioration on storage has been studied by a modification of the method of high pressure chromatography which allows better definition of the individual lipids. The free fatty acid concentration rose markedly while cconcentrations of phosphatidyl choline, phosphatidyl ethanolamine and phosphatidyl serine were reduced. An oxidative process is suggested and supported by the increase in malonaldehyde levels. The method of production of the BCT involves maceration of human brain which causes the breakdown of cell membranes and the release of many potentially oxidative materials from subcellular particles. The loss of procoagulant activity of BCT on storage may be due to the loss of phospholipid or to the increase of inhibitory degradation products, i.e. free fatty acid and malonaldehyde. The examination of the lipid class composition of tissue thromboplastin extracts appears useful, therefore, not only in determining the phospholipids necessary for procoagulant activity, but also in monitoring the deterioration of tissue thromboplastins on storage.
Linear-Time Algorithms for Linear Programming in $R^3 $ and Related Problems (1983)

Linear-time algorithms for linear programming in $R^2 $ and $R^3 $ are presented. The methods used are applicable for other graphic and geometric problems as well as quadratic programming. For example, a linear-time algorithm is given for the classical problem of finding the smallest circle enclosing n given points in the plane; this disproves a conjecture by Shamos and Hoey [Proc.16th IEEE Symposium on Foundations of Computer Science, 1975] that this problem requires $\Omega (n\log n)$ time. An immediate consequence of the main result is that the problem of linear separability is solvable in linear time. This corrects an error in Shamos and Hoey’s paper, namely, that their $ O (n\log n)$ algorithm for this problem in the plane was optimal. Also, a linear-time algorithm is given for the problem of finding the weighted center of a tree, and algorithms for other common location-theoretic problems are indicated. The results apply also to the problem of convex quadratic programming in three dimensions. The results have already been extended to higher dimensions, and we know that linear programming can be solved in linear time when the dimension is fixed. This will be reported elsewhere; a preliminary version is available from the author.
The role of WDR5 in silencing human fetal globin gene expression (2012)

Our data are consistent with a model in which WDR5 binds the γ-globin promoter in a PRMT5-dependent manner; H3K4me3 induced at the γ-globin promoter by WDR5 may result in the recruitment of the ING2-associated HDAC1 component and consequent silencing of γ-globin gene expression.
Analysis of UV‐excited fluorochromes by flow cytometry using near‐ultraviolet laser diodes (2004)

These evaluations indicate that near-UV laser diodes installed on a cuvette-based flow cytometer performed nearly as well as more powerful solid-state UV lasers on the same instrumentation, and comparably to more powerful ion lasers on a jet-in-air system, and. Despite their limited power, integration of these small and inexpensive lasers into benchtop flow cytometers should allow the use of flow cytometric applications requiring UV excitation on a wide variety of instruments.
Formation of Solid Human Mammary Carcinoma In Vitro (1977)

An established line of human breast carcinoma, MCF-7, when cultured within the artificial capillary system, formed solid masses of tissue. Acinar and ductular patterns developed, having the ultrastructural appearance of breast tissue that responds to exogenous hormones.
Characterization of vanadium diffusion barriers in Nb-Sn composite wires (1987)

Ductile vanadium has been explored for use as a diffusion barrier material in niobium-tin composite wires. Vanadium is found to co-process well, standing over 99.995% area reduction without anneal. Resistance ratios greater than 300 to 1 (0°c to 20K) have been measured in reacted composite wire with noncopper current densities greater than 1700 A/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 10 Tesla, 4.2K. Vanadium forms an intermetallic compound on the tin side which should not be superconducting above 4.2K. The composite residual resistance ratio (RRR) is seen to be dependent on reaction conditions being higher as the reaction temperature is dropped. To determine the source of this effect a copper-vanadium composite was fabricated. Features similar to the superconducting wire were observed. There is a reasonable overlap of reaction conditions suitable for both the superconductor and the copper making high RRR possible for optimized conductors.
Errol E Harris, Formal, Transcendental and Dialectical Thinking: Logic and Reality, Albany: SUNY Press, 1987, pp ii + 289. - Errol E Harris, The Reality of Time, Albany: SUNY Press, 1988, pp xii + 204. (1991)

Errol E Harris, Formal, Transcendental and Dialectical Thinking: Logic and Reality, Albany: SUNY Press, 1987, pp ii + 289. - Errol E Harris, The Reality of Time, Albany: SUNY Press, 1988, pp xii + 204. - Volume 12 Issue 1-2
Deletion of Viral microRNAs in the Oncogenesis of Epstein–Barr Virus-Associated Lymphoma (2021)

Epstein-Barr virus (EBV), which encodes >80 genes and nearly 50 non-coding RNAs, is a double-stranded DNA virus. EBV is associated with various types of lymphomas and lymphoproliferative disorders not only of B-cell but also T/NK-cell origin. However, the oncogenic mechanism remains poorly understood, including the EBV receptors expressed on T/NK cells, relationship of EBV with host genes, and epigenetic regulation of EBV and host genes. The roles of host and viral non-coding RNAs during tumorigenesis have been elucidated. EBV encodes at least 49 mature microRNAs (miRNAs), of which 44 are located in <i>Bam</i>HI-A rightward transcripts (BARTs) region, and the remaining five are located in <i>Bam</i>HI-H rightward fragment 1. BART miRNAs modulate cell differentiation, proliferation, apoptosis, and the cell cycle, and they are considered positive regulators of oncogenesis. We and others have recently reported that EBV-positive lymphomas frequently possess large deletions in BART miRNA clusters, suggesting that some viral miRNAs have suppressive effects on oncogenesis, and that deletion of these miRNAs may aid lymphoma formation.
Light‐Induced Water Splitting with Hematite: Improved Nanostructure and Iridium Oxide Catalysis (2010)

Revved-up rust! Light-induced water splitting over iron oxide (hematite) has been achieved by using a particle-assisted deposition technique and IrO2-based surface catalysis. Photocurrents in excess of 3 mA cm−2 were obtained at +1.23 V versus the reversible hydrogen electrode under AM 1.5 G 100 mW cm−2 simulated sunlight. These photocurrents are unmatched by any other oxide-based photoanode. FTO=fluorine-doped tin oxide. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.