gebhart/patrepeval huggingface dataset:
Recognizing human actions (2005)

Recognition of human actions from video sequences is a very active area of research in Computer Vision. An important step in any action recognition approach is the extraction of useful information form a raw video data and its subsequent representation. The representation should account for the variability that arises when arbitrary cameras capture humans performing actions.UCF Computer Vision group has been very active in action recognition area. In this talk, I will present our action recognition work employing a variety of representations: a single point, anatomical landmarks on the human body, and complete contour of the human body. I will also explicitly identify three important sources of variability: (1) viewpoint, (2) execution rate, and (3) anthropometry of actors, and propose a model of human actions that allows us to address all three. Our hypothesis is that the variability associated with the execution of an action can be closely approximated by a linear combination of action bases in joint spatio-temporal space. We demonstrate that such a model bounds the rank of a matrix of image measurements and that this bound can be used to achieve recognition of actions based only on imaged data.
Precocious Mammary Gland Development and Milk Protein Synthesis in Transgenic Mice Ubiquitously Expressing Human Growth Hormone* (1991)

A chimeric gene comprising the hydroxymethylglutaryl coenzyme-A reductase promoter and the human GH (hGH) genomic sequences was used to create transgenic mice expressing hGH in all tissues. In transgenic females, morphological development of the mammary gland and milk protein (WAP) expression commences at 3 weeks of age. At 8 weeks of age the mammary gland is morphologically and functionally comparable to that normally reached after 14-15 days of gestation. Precocious development correlated with local expression of hGH in mammary gland. Organ culture in the presence of different lactogenic hormones revealed that insulin and hydrocortisone are sufficient to maintain transcription of the WAP gene in transgenic mammary gland. In contrast, WAP transcription in normal gland required either hGH or PRL in addition to insulin and hydrocortisone. However, the effect of hGH on mammary differentiation does not appear to be solely mediated through an interaction with PRL receptors, since PRL, when added to cultured mammary tissues, did not elicit an equivalent response.
Glycoprotein IIb/IIIa autoantigenic repertoire in chronic idiopathic thrombocytopenic purpura (1995)

The objective of the present study was to further disclose the autoantigenic repertoire carried by the platelet glycoprotein (GP) IIb/IIIa complex. IgG-F(ab')2 fragments were prepared from two prototype ITP patients, and their ability to block the binding of GPIIb/IIIa reactive antibodies derived from other patients with ITP was evaluated using a modified MAIPA asay; a PlA1 alloantiserum and 20 normal sera were included as controls. It was found that the two prototype IgG-F(ab')2 fragments were each able to significantly block the binding of serum IgG to GPIIb/IIa in six (55%) and seven (64%) out of 11 patients with chronic ITP, respectively. No significant blocking effect was observed for IgG-F(ab')2 fragments prepared from normal subjects. Also, the binding of the PlA1 alloantiserum to its epitope on GPIIIa was not affected by any of the blocking IgG-F(ab')2 fragments exploited in the study. These data substantiate that in chronic ITP at least half of the GPIIb/IIIa reactive sera bind to homogenous autoepitopes.
Fast-Lock Hybrid PLL Combining Fractional-$N$ and Integer-$N$ Modes of Differing Bandwidths (2008)

We introduce a single-loop PLL that operates in a narrower-bandwidth, integer-N mode during phase lock and in a wider-bandwidth, fractional-N mode during transient. This hybrid PLL, as a generalization of the conventional variable-bandwidth PLL that shifts only its bandwidth, simultaneously achieves the fast-locking advantage of the fractional-N PLL and design simplicity of the integer-N PLL, and as such, brings benefits in certain important PLL applications. In addition, the frequency division mode switching, unique in the hybrid PLL, enables a new, more digital protocol to execute bandwidth switching. A CMOS IC prototype attests to the validity of the proposed approach.
Crinecerfont (NBI-74788), a novel CRF1 receptor antagonist, reduces adrenal androgens and precursors in patients with classic congenital adrenal hyperplasia: Results from a phase 2, multiple-dose study (2020)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Methanogenic biodegradation of two-ringed polycyclic aromatic hydrocarbons (2012)

Polycyclic aromatic hydrocarbons (PAH) are widespread in methane-rich subsurface environments, such as oil reservoirs and fuel-contaminated aquifers; however, little is known about the biodegradation of these compounds under methanogenic conditions. To assess the metabolism of PAH in the absence of electron acceptors, a crude oil-degrading methanogenic enrichment culture was tested for the ability to biodegrade naphthalene, 1-methylnaphthalene (1-MN), 2-methylnaphthalene (2-MN), and 2, 6-dimethylnaphthalene (2, 6-diMN). When methane was measured as an indicator of metabolism, nearly 400 μmol of methane was produced in the 2-MN- and 2, 6-diMN-amended cultures relative to substrate-unamended controls, which is close to the amount of methane stoichiometrically predicted based on the amount of substrate added (51-56 μmol). In contrast, no substantial methane was produced in the naphthalene- and 1-MN-amended enrichments. In time course experiments, metabolite analysis of enrichments containing 2-MN and 2, 6-diMN revealed the formation of 2-naphthoic acid and 6-methyl-2-naphthoic acid, respectively. Microbial community analysis by 454 pyrosequencing revealed that these PAH-utilizing enrichments were dominated by archaeal members most closely affiliated with Methanosaeta and Methanoculleus species and bacterial members most closely related to the Clostridiaceae, suggesting that these organisms play an important role in the methanogenic metabolism of the substituted naphthalenes in these cultures.
Synthesis and Characterization of SiO2 Nanoparticles by Sol-Gel Process and Its Degradation of Methylene Blue (2014)

Nanomaterials are used for the miniaturization of particular electronic device. But new era of technology demands a cheaper and more commercial method to produce excellent material especially silicon dioxide. The present work deals with the sol-gel synthesis of SiO2 material and also provides a basic understanding of the effect of calcination temperature on the growth of SiO2 by hydrolysis of TEOS with ethanol, deionized water and catalyst mixture. The properties of resulting materials were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), AFM and optical properties through UV-visible spectroscopy and Photo Luminescence (PL). The XRD study of pure SiO2 with calcination temperature at 300°C shows well crystalline characteristics and having hexagonal crystal structure. SEM results show obtained silica particles were having spherical morphology. The proper temperature the PL intensity was reduced and the shape of the emission spectrum slightly split into sharp peaks. UV-visible absorbance spectra of the silica samples having wide band gap showing absorbance in the ultra violet region. The
Infrared Sensing for On-Line Weld Geometry Monitoring and Control (1995)

This paper describes a method for on-line weld geometry monitoring and control using a single front-side infrared sensor. Variations in plate thickness, shielding gas composition and minor element content are known to cause weld geometry changes. These changes in the weld geometry can be distinctly detected from an analysis of temperature gradients computed from infrared data. Deviations in temperature gradients were used to control the bead width and depth of penetration during the welding process. The analytical techniques described in this paper have been used to control gas tungsten arc and gas metal arc welding processes.
Introspective Classification with Convolutional Nets (2017)

We propose introspective convolutional networks (ICN) that emphasize the importance of having convolutional neural networks empowered with generative capabilities. We employ a reclassification-by-synthesis algorithm to perform training using a formulation stemmed from the Bayes theory. Our ICN tries to iteratively: (1) synthesize pseudo-negative samples; and (2) enhance itself by improving the classification. The single CNN classifier learned is at the same time generative --- being able to directly synthesize new samples within its own discriminative model. We conduct experiments on benchmark datasets including MNIST, CIFAR-10, and SVHN using state-of-the-art CNN architectures, and observe improved classification results.
Pharmacologic TWIK‐Related Acid‐Sensitive K+ Channel (TASK‐1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model (2020)

Background The tandem of P domains in a weak inward rectifying K+ channel (TWIK)-related acid-sensitive K<sup>+</sup> channel (TASK-1; hK<sub>2P</sub>3.1) two-pore-domain potassium channel was recently shown to regulate the atrial action potential duration. In the human heart, TASK-1 channels are specifically expressed in the atria. Furthermore, upregulation of atrial TASK-1 currents was described in patients suffering from atrial fibrillation (AF). We therefore hypothesized that TASK-1 channels represent an ideal target for antiarrhythmic therapy of AF. In the present study, we tested the antiarrhythmic effects of the high-affinity TASK-1 inhibitor A293 on cardioversion in a porcine model of paroxysmal AF. Methods and Results Heterologously expressed human and porcine TASK-1 channels are blocked by A293 to a similar extent. Patch clamp measurements from isolated human and porcine atrial cardiomyocytes showed comparable TASK-1 currents. Computational modeling was used to investigate the conditions under which A293 would be antiarrhythmic. German landrace pigs underwent electrophysiological studies under general anesthesia. Paroxysmal AF was induced by right atrial burst stimulation. After induction of AF episodes, intravenous administration of A293 restored sinus rhythm within cardioversion times of 177±63 seconds. Intravenous administration of A293 resulted in significant prolongation of the atrial effective refractory period, measured at cycle lengths of 300, 400 and 500 ms, whereas the surface ECG parameters and the ventricular effective refractory period lengths remained unchanged. Conclusions Pharmacological inhibition of atrial TASK-1 currents exerts antiarrhythmic effects in vivo as well as in silico<i>,</i> resulting in acute cardioversion of paroxysmal AF. Taken together, these experiments indicate the therapeutic potential of A293 for AF treatment.
Validity of SW982 synovial cell line for studying the drugs against rheumatoid arthritis in fluvastatin-induced apoptosis signaling model. (2014)

Collectively, our data indicate that fluvastatin induces apoptotic cell death in TNFα-stimulated SW982 human synovial cells through the inactivation of the geranylgerenylated membrane fraction of RhoA and Rac1 proteins and the subsequent inhibition of the PI3K/Akt signaling pathway. This finding shows the validity of SW982 cell line for RA study.
Glycerol–Silicone Elastomers as Active Matrices with Controllable Release Profiles (2018)

Drug release regimes must be controlled for the optimal therapeutic effect. Although it is relatively straightforward to create first-order release matrices, it can be challenging to avoid an initial burst. Matrices with zero-order profiles are perceived to be beneficial in many cases but are even more difficult to formulate. We describe the straightforward synthesis of elastomeric composites prepared from silicone in which the active substance is dispersed in glycerol. The release of glycerol-soluble actives from the films of these materials was shown to be tunable with respect to the order of release (zero- or first-order) simply by changing the glycerol content. Importantly, release from the elastomers showed no burst effect. The discrete glycerol domains embedded within a silicone matrix act as reservoirs for active substances. Upon contact with aqueous media, the active substances are released from the matrices exhibiting zero-order, near zero-order, or first-order release kinetics. Various parameters that could influence the release process, including glycerol content, glycerol domain size, or membrane thickness, are thoroughly investigated, elucidating guidelines for creating matrices capable of delivering the active substances at desired rates. Additionally, the composites proved to absorb significant amounts of liquid water (up to 1850% of sample mass), a feature that can be tuned by the manipulation of the composite structure.
An efficient algorithm for VLSI network partitioning problem using a cost function with balancing factor (1993)

This paper presents an efficient algorithm for network partitioning problem, which improves Fiduccia and Mattheyses' (F-M's) algorithm (1982). We have noticed that the main problem of F-M's algorithm is that the cell move operation is largely influenced by the balancing constraint. In order to handle this kind of inherent limitation in F-M's algorithm, a cost function is adopted which reflects balance degree of a partition as well as its cutset size. The weighting factor R is introduced in the cost function to determine the relative importance of the two factors: cutset size and balance degree. Using this cost function, we propose an iterative improvement algorithm which has the time complexity of O(b(m+c/sup 2/)), where b is the number of blocks, m is the size of network, and c is the number of cells. It is proven that the proposed algorithm guarantees to find a balanced partition if the value of R satisfies a certain condition. Experimental results show that the proposed algorithm outperforms F-M's algorithm in most cases.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
High‐Efficiency, Solution‐Processed, Multilayer Phosphorescent Organic Light‐Emitting Diodes with a Copper Thiocyanate Hole‐Injection/Hole‐Transport Layer (2014)

Copper thiocyanate (CuSCN) is introduced as a hole-injection/hole-transport layer (HIL/HTL) for solution-processed organic light-emitting diodes (OLEDs). The OLED devices reported here with CuSCN as HIL/HTL perform significantly better than equivalent devices fabricated with a PEDOT:PSS HIL/HTL, and solution-processed, phosphorescent, small-molecule, green OLEDs with maximum luminance ≥10 000 cd m(-2) , maximum luminous efficiency ≤50 cd A(-1) , and maximum luminous power efficiency ≤55 lm W(-1) are demonstrated.
A silicon avalanche photodetector fabricated with standard CMOS technology with over 1 THz gain-bandwidth product (2010)

We present a silicon avalanche photodetector (APD) fabricated with standard complementary metal-oxide-semiconductor (CMOS) technology without any process modification or special substrates. The CMOS-APD is based on N+/P-well junction, and its current-voltage characteristics, responsivity, avalanche gain, and photodetection frequency response are measured. Gain-bandwidth product over 1 THz is achieved with the CMOS-APD having avalanche gain of 569 and 3-dB photodetection bandwidth of 3.2 GHz.
Conformational Requirements of Collagenous Peptides for Recognition by the Chaperone Protein HSP47 (2000)

The collagen binding chaperone HSP47 interacts with procollagen in the endoplasmic reticulum and plays a crucial role in the biosynthesis of collagen. We recently demonstrated that typical collagen model peptides, (Pro-Pro-Gly)(n), possess sufficient structural information for interaction with HSP47 (Koide, T., Asada, S., and Nagata, K. (1999) J. Biol. Chem. 274, 34523-34526). Here we show that binding of (Gly-Pro-Pro)(n) peptides to HSP47 can be detected using the two-hybrid system in yeast if a trimerizing domain is fused to the C termini of the peptides. Some peptides interacted with HSP47 at a lowered assay temperature at 24 degrees C but not at 30 degrees C, indicating the importance of conformational change of the substrate peptides. To analyze the spectrum of HSP47 substrate sequences, we performed two-hybrid screening of collagen-like peptides in designed random peptide libraries using HSP47 as a bait. In selected peptides, the enrichment ratio calculated for each amino acid residue correlated strongly with the contribution of the residue to triple-helix stability independently determined using synthetic collagen model peptides. Taken together, our results suggest that HSP47 preferentially recognizes collagenous Gly-X-Y repeats in triple-helical conformation. We also demonstrated that screening of combinatorial peptide libraries is a powerful strategy to determine conformational requirements as well as the elucidation of binding motifs in primary structure.
The Role of the Ovarian Tumor Marker CA125 (MUC16) in the Suppression of Human Immune Responses (2005)

s: Abstracts for the 20th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (Primary Authors are Italicized): NATURAL KILLER CELLS AND INNATE IMMUNITY
Cloning and Expression of a <i>Clostridium acetobutylicum</i> Alcohol Dehydrogenase Gene in <i>Escherichia coli</i> (1988)

An alcohol dehydrogenase (ADH) gene from Clostridium acetobutylicum was cloned on a recombinant plasmid, pCADH100. Escherichia coli HB101, and an allyl alcohol-resistant mutant, HB101-adh1, containing this plasmid were unable to grow aerobically or anaerobically on agar media containing sublethal concentrations of allyl alcohol. E. coli HB101 and HB101-adh1 transformed with the plasmid pCADH100 produced increased levels of ethanol when grown anaerobically under alkaline conditions in the absence of nitrate. Cell extracts from aerobically and anaerobically grown E. coli HB101(pCADH100) and HB101-adhl(pCADH100) cells exhibited increased levels of NADP-dependent ADH activity with either ethanol or butanol as the substrate. The inability of E. coli HB101(pCADH100) to grow in the presence of allyl alcohol correlated with the appearance of an NADP-dependent ADH activity band on nondenaturing polyacrylamide gel electrophoresis with either ethanol or butanol as the substrate. The position of the cloned NADP-dependent ADH activity bands in E. coli HB101(pCADH100) cell extracts with either ethanol or butanol as the substrate coincided with the position of a single NADP-dependent ADH activity band in extracts of C. acetobutylicum cells. E. coli HB101(pCADH100) cell extracts prepared from both aerobically and anaerobically grown cells exhibited an additional protein band with an apparent M(r) of approximately 33,000 on sodium dodecyl sulfate-polyacryl-amide gel electrophoresis which was absent in cell extracts of E. coli HB101. A protein band with a similar apparent M(r) was observed in cell extracts of C. acetobutylicum, and in vitro transcription and translation experiments with pCADH100 produced a major protein product with a similar apparent M(r).
Lysosomal Enzyme Activities in Conjunctival Tissues of Patients With Keratoconus (1994)

Our results suggest that the conjunctival epithelium may be altered in keratoconus. Elevation of lysosomal enzyme levels has been demonstrated in the epithelium of corneas with keratoconus, implicating a role of this layer in the disease. The conjunctival abnormality seems to corroborate the corneal epithelial theory. It also adds one dimension to the pathogenesis of keratoconus.
Benefit of linearizing power amplifiers in multi-port amplifier subsystems (2008)

In this paper, we investigate the effects of nonlinear power amplifiers in a multi-port amplifier subsystem, and the benefit resulting from applying a type-based linearization approach. Computer simulations show that power efficiency and system performance can be significantly improved by linearizing the power amplifiers.
Snoek’s limit in high-frequency permeability of polycrystalline Ni–Zn, Mg–Zn, and Ni–Zn–Cu spinel ferrites (2000)

Three series of polycrystalline spinel ferrite, Ni–Zn ferrite, Mg–Zn ferrite and Ni–Zn–Cu ferrite, were prepared by the usual ceramic sintering method. The complex permeability spectra of each were measured. The low-frequency permeability increases with zinc content. However, the natural resonance frequency shifted down as the zinc content increased. The spectra were also numerically separated into spin rotational and domain wall resonance components. For the spin rotational contribution, which remained in the high frequency region, the static spin susceptibility increased and the spin resonance frequency shifted down with an increase in zinc content. Additionally, it was found that the product of the static spin susceptibility and the spin resonance frequency is proportional to the magnetization, irrespective of the kind of spinel ferrite. These relationships correspond to Snoek’s limitation rule. From these results, it was clarified that polycrystalline ferrites having large magnetization are suitable for high-frequency applications.
Modeling light transmission in silicon waveguides (2012)

We propose and experimentally validate a detailed model for silicon nanophotonic waveguides which predicts the full spectral distribution function of propagation statistics including the role of interfaces and roughness.
Bases and foundations of the treatment of peritoneal carcinomatosis: Review article (2016)

Peritoneal carcinomatosis refers to a shedding or tumor that spreads to the peritoneal serosa and structures of the abdominal cavity. It is an entity with a poor prognosis. Several conditions can cause this, the most common being colon, rectum, ovary, stomach or appendix cancers, including peritoneal pseudomyxoma, among others. The abdominal cavity invasion is considered a clinical stage IV. For a long time life expectancy of this entity was very short. With the advent of meticulous techniques in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) the prognosis of patients has changed. In some conditions, these procedures are standard treatments. CRS is a very important prognostic factor; leaving a less residual disease in the patient, the evolution will be better. The HIPEC starts immediately after the surgical event. The hyperthermia increases the cytotoxic effect of antineoplastic drugs. Numerous studies have appeared in medical literature wherein the clear improvement in survival of the affected population is demonstrated. It is essential that a multidisciplinary team participates in the decision for the best treatment option and the maximum clinical benefit of the patients.