gebhart/patrepeval huggingface dataset:
Speculative DMA for architecturally visible storage in instruction set extensions (2008)

Instruction set extensions (ISEs) can accelerate embedded processor performance. Many algorithms for ISE generation have shown good potential; some of them have recently been expanded to include Architecturally Visible Storage (AVS) - compiler-controlled memories, similar to scratchpads, that are accessible only to ISEs. To achieve a speedup using AVS, Direct Memory Access (DMA) transfers are required to move data from the main memory to the AVS; unfortunately, this creates coherence problems between the AVS and the cache, which previous methods for ISEs with AVS failed to address; additionally, these methods need to leave many conservative DMA transfers in place, whose execution significantly limits the achievable speedup. This paper presents a memory coherence scheme for ISEs with AVS, which can ensure execution correctness and memory consistency with minimal area overhead. We also present a method that speculatively removes redundant DMA transfers. Cycle-accurate experimental results were obtained using an FPGA-emulation platform. These results show that the application-specific instruction-set extended processors with speculative DMA-enhanced AVS gain significantly over previous techniques, despite the overhead of the coherence mechanism.
Cloned Human and Rat Galanin GALR3 Receptors (1998)

The neuropeptide galanin has been implicated in the regulation of processes such as nociception, cognition, feeding behavior, and hormone secretion. Multiple galanin receptors are predicted to mediate its effects, but only two functionally coupled receptors have been reported. We now report the cloning of a third galanin receptor distinct from GALR1 and GALR2. The receptor, termed GALR3, was isolated from a rat hypothalamus cDNA library by both expression and homology cloning approaches. The rat GALR3 receptor cDNA can encode a protein of 370 amino acids with 35% and 52% identity to GALR1 and GALR2, respectively. Localization of mRNA by solution hybridization/RNase protection demonstrates that the GALR3 transcript is widely distributed, but expressed at low abundance, with the highest levels in the hypothalamus and pituitary. We also isolated the gene encoding the human homologue of GALR3. The human GALR3 receptor is 90% identical to rat GALR3 and contains 368 amino acids. Binding of porcine 125I-galanin to stably expressed rat and human GALR3 receptors is saturable (rat KD = 0.98 nM and human KD = 2.23 nM) and displaceable by galanin peptides and analogues in the following rank order: rat galanin, porcine galanin approximately M32, M35 approximately porcine galanin-(-7 to +29), galantide, human galanin > M40, galanin-(1-16) > [D-Trp2]galanin-(1-29), galanin-(3-29). This profile resembles that of the rat GALR1 and GALR2 receptors with the notable exception that human galanin, galanin-(1-16), and M40 show lower affinity at GALR3. In Xenopus oocytes, activation of rat and human GALR3 receptors co-expressed with potassium channel subunits GIRK1 and GIRK4 resulted in inward K+ currents characteristic of Gi/Go-coupled receptors. These data confirm the functional efficacy of GALR3 receptors and further suggest that GALR3 signaling pathways resemble those of GALR1 in that both can activate potassium channels linked to the regulation of neurotransmitter release.
Winner determination in combinatorial auction generalizations (2002)

Combinatorial markets where bids can be submitted on bundles of items can be economically desirable coordination mechanisms in multiagent systems where the items exhibit complementarity and substitutability. There has been a surge of research on winner determination in combinatorial auctions. In this paper we study a wider range of combinatorial market designs: auctions, reverse auctions, and exchanges, with one or multiple units of each item, with and without free disposal. We first theoretically characterize the complexity of finding a feasible, approximate, or optimal solution. Reverse auctions with free disposal can be approximated (even in the multi-unit case), although auctions cannot. When XOR-constraints between bids are allowed (to express substitutability), the hardness turns the other way around: even finding a feasible solution for a reverse auction or exchanges is ΝΠ-complete, while in auctions that is trivial. Finally, in all of the cases without free disposal, even finding a feasible solution is ΝΠ-complete.We then ran experiments on known benchmarks as well as ones which we introduced, to study the complexity of the market variants in practice. Cases with free disposal tended to be easier than ones without. On many distributions, reverse auctions with free disposal were easier than auctions with free disposal---as the approximability would suggest---but interestingly, on one of the most realistic distributions they were harder. Single-unit exchanges were easy, but multi-unit exchanges were extremely hard.
Genetic interactions in the adrenergic system genes: analysis of antipsychotic‐induced weight gain (2011)

Our results suggest that genetic polymorphisms in the adrenergic system may not play a major role in AP-induced weight gain; however, adrenergic 2A receptor gene that produced previously the most consistent associations with this phenotype showed a significant interaction with the monoamine oxidase A in weight gainers.
Rethinking TLB Designs in Virtualized Environments (2017)

With increasing deployment of virtual machines for cloud services and server applications, memory address translation overheads in virtualized environments have received great attention. In the radix-4 type of page tables used in x86 architectures, a TLB-miss necessitates up to 24 memory references for one guest to host translation. While dedicated page walk caches and such recent enhancements eliminate many of these memory references, our measurements on the Intel Skylake processors indicate that many programs in virtualized mode of execution still spend hundreds of cycles for translations that do not hit in the TLBs.
Ultra-fast line-field low coherence holographic elastography using spatial phase shifting (2017)

Optical coherence elastography (OCE) is an emerging technique for quantifying tissue biomechanical properties. Generally, OCE relies on point-by-point scanning. However, long acquisition times make point-by-point scanning unfeasible for clinical use. Here we demonstrate a noncontact single shot line-field low coherence holography system utilizing an automatic Hilbert transform analysis based on a spatial phase shifting technique. Spatio-temporal maps of elastic wave propagation were acquired with only one air-pulse excitation and used to quantify wave velocity and sample mechanical properties at a line rate of 200 kHz. Results obtained on phantoms were correlated with data from mechanical testing. Finally, the stiffness of porcine cornea at different intraocular pressures was also quantified <i>in situ</i>.
[Tetravalent dengue vaccine development]. (2010)

The Sanofi Pasteur tetravalent dengue vaccine candidate (TV) is composed of four recombinant live attenuated vaccines based on a yellow fever virus vaccine 17D (YFV 17D) backbone, each expressing the prM and envelope genes of one of the four dengue virus serotypes. Pre-clinical studies have demonstrated that the TV dengue vaccine is genetically and phenotypi- cally stable, non-hepatotropic, less neurovirulent than YFV 17D and does not infect mosquitoes by the oral route. In clinics, TV dengue vaccine reactogeni- city, viraemia induction and antibody responses were investigated in three Phase II trials in endemic and non-endemic countries, which demonstrated its good safety and immunogenicity. An extensive clinical development program for dengue TV is underway including an efficacy trial in Thailand, in an area of high dengue incidence. Assuming continued successful outcomes, initial submissions to regulatory authorities are envisaged within a 5-year period.
Thick-well quantum-structured solar cells: design criteria for nano-enhanced absorbers (2013)

Nano-enhanced solar cells incorporating III-V quantum wells or quantum dots have the potential to
revolutionize the performance of photovoltaic devices. Extended spectral response characteristics have
been widely demonstrated in both quantum well and quantum dot solar cells using a variety of different
III-V materials. To fully leverage the increased spectral response of nano-enhanced solar cells, new
device designs are discussed that can both maximize the current generating capability of the limited
volume of narrow band-gap material and minimize the unwanted carrier recombination that degrades the
voltage output.
Biomechanical Basis of Oscillometric Blood Pressure Measuring Technique (2009)

Non-invasive blood pressure (BP) measurement has been used clinically for over a century to diagnose hypertension. Compared with the auscultatory technique, the oscillometric technique requires less professional training and is widely used in automatic BP measurement devices. Currently, most of these devices measure and record amplitude of cuff pressure oscillation, and then calculate diastolic and systolic pressure using characteristic ratios and designed algorithms. A finite element (FE) model is developed to study the biomechanical basis of this technique. The model identifies that errors were caused by mechanical factors of the soft tissue and the shape of the arm. By personalizing the parameters for each patient, the accuracy of the measurement will be improved for all age groups.
Hydrodesulfurization by reduced molybdenum sulfides: activity and selectivity of Chevrel phase catalysts (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrodesulfurization by reduced molybdenum sulfides: activity and selectivity of Chevrel phase catalystsKevin F. McCarty and Glenn L. SchraderCite this: Ind. Eng. Chem. Prod. Res. Dev. 1984, 23, 4, 519–524Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/i300016a002https://doi.org/10.1021/i300016a002research-articleACS PublicationsRequest reuse permissionsArticle Views299Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Advances in blue-green laser diodes (2002)

Great strides have been made in the area of Il-VI based short wavelength laser diodes since the first demonstration of pulsed blue-green lasers by 3M Company in 1991. These advances have been primarily due to a greater understanding of the material growth, including substrate preparation, the use of the MgZnSSe quaternary system, defect reduction, and p-type ohmic contacts.
Injectable and Cytocompatible Tough Double‐Network Hydrogels through Tandem Supramolecular and Covalent Crosslinking (2016)

Double-network theory is extended to include guest-host interactions, enabling injectability and cytcompatibility of tough hydrogels. Noncovalent interactions are used as a sacrificial network to toughen covalently crosslinked hydrogels formed from hyaluronic acid. Shear thinning of supramolecular bonds allows hydrogel injection and rapid self-healing, while gentle reaction conditions permit cell encapsulation with high viability.
Optimal linearity testing of analog-to-digital converters using a linear model (2003)

To maintain an acceptable level of quality in the production of analog-to-digital converters (ADCs), the linearity metrics of every ADC has to be measured and checked against performance specification limits. As ADCs continue to improve in resolution, their testing has becoming increasingly demanding in terms of test time. In this paper, we demonstrate a technique for reducing the test time for ADCs. The technique is shown to be significantly better than currently available techniques and can be easily integrated into current production test methodologies. Experimental results in simulation and on actual hardware are shown to demonstrate the technique.
Definition of the M-Conotoxin Superfamily:  Characterization of Novel Peptides from Molluscivorous <i>Conus</i> Venoms (2005)

Most of the >50,000 different pharmacologically active peptides in Conus venoms belong to a small number of gene superfamilies. In this work, the M-conotoxin superfamily is defined using both biochemical and molecular criteria. Novel excitatory peptides purified from the venoms of the molluscivorous species Conus textile and Conus marmoreus all have a characteristic pattern of Cys residues previously found in the mu-, kappaM-, and psi-conotoxins (CC-C-C-CC). The new peptides are smaller (12-19 amino acids) than the mu-, kappaM-, and psi-conotoxins (22-24 amino acids). One peptide, mr3a, was chemically synthesized in a biologically active form. Analysis of the disulfide bridges of a natural peptide tx3c from C. textile and synthetic peptide mr3a from C. marmoreus showed a novel pattern of disulfide connectivity, different from that previously established for the mu- and psi-conotoxins. Thus, these peptides belong to a new group of structurally and pharmacologically distinct conotoxins that are particularly prominent in the venoms of mollusc-hunting Conus species. Analysis of cDNA clones encoding the novel peptides as well as those encoding mu-, kappaM-, and psi-conotoxins revealed highly conserved amino acid residues in the precursor sequences; this conservation in both amino acid sequence and in the Cys pattern defines a gene superfamily, designated the M-conotoxin superfamily. The peptides characterized can be provisionally assigned to four distinct groups within the M-superfamily based on sequence similarity within and divergence between each group. A notable feature of the superfamily is that two distinct structural frameworks have been generated by changing the disulfide connectivity on an otherwise conserved Cys pattern.
Security X-ray Screening with Modulated-Energy Pulses (2019)

This paper provides a brief overview of new screening methods that employ Modulated-Energy X-ray Pulses (MEXP) to provide a number of near-simultaneous multi-energy measurements in transmission-, backscatter-, and Computed Tomography (CT) security systems. In transmission X-ray cargo screening, these multi-energy measurements improve material discrimination, maximize penetration, and enhance contrast resolution while simultaneously reducing inspection time and dose to the environment, thus resulting in a smaller exclusion zone. In backscatter systems, the use of this method will increase penetration and improve image quality of concealed objects located deeper below the surface. Specifically, different depths within an object can be probed simultaneously. In CT, our MEXP approach mitigates the main disadvantages of the conventional dual-energy technique: a) distortion of image of the boundaries between regions with large difference in density; b) limited range of object thickness where material decomposition is valid; c) ambiguity and artifacts caused by sampling different regions due to motion of the object between interlaced pulses with distinct energies. Results of testing of the prototype of high speed Adaptive, Multi-Energy Cargo Inspection System (AMEXIS) will be presented. Progress in the development of MEXP-based backscatter inspection system, and systems for cargo screening with Adaptive CT will also be shown.
Polymerization of lactams, 39. Condensation as side reaction in the anionic polymerization of 2‐pyrrolidone (1981)

Abstract Polymerization mixtures before extraction and extracted polymers prepared by the anionic polymerization of 2‐pyrrolidone with various initiating systems were characterized by their content of β‐ketoamide structures ( 5 ) as a measure of side reactions of the propagation sites by condensation. With N ‐acyllactams, used as activators, the content of these structures 5 in poly(2‐pyrrolidone) was found to increase proportionally to the polymerization time, which may have a negative effect on the thermal stability of the polymer.
Melatonin in preservation solutions prevents ischemic injury in rat kidneys (2022)

Transplantation is lifesaving and the most effective treatment for end-stage organ failure. The transplantation success depends on the functional preservation of organs prior to transplantation. Currently, the University of Wisconsin (UW) and histidine-tryptophan-ketoglutarate (HTK) are the most commonly used preservation solutions. Despite intensive efforts, the functional preservation of solid organs prior to transplantation is limited to hours. In this study, we modified the UW solution containing components from both the UW and HTK solutions and analyzed their tissue-protective effect against ischemic injury. The composition of the UW solution was changed by reducing hydroxyethyl starch concentration and adding Histidine/Histidine-HCl which is the main component of HTK solution. Additionally, the preservation solutions were supplemented with melatonin and glucosamine. The protective effects of the preservation solutions were assessed by biochemical and microscopical analysis at 2, 10, 24, and 72 h after preserving the rat kidneys with static cold storage. Lactate dehydrogenase (LDH) activity in preservation solutions was measured at 2, 10, 24, and 72. It was not detectable at 2 h of preservation in all groups and 10 h of preservation in modified UW+melatonin (mUW-m) and modified UW+glucosamine (mUW-g) groups. At the 72nd hour, the lowest LDH activity (0.91 IU/g (0.63-1.17)) was measured in the mUW-m group. In comparison to the UW group, histopathological damage score was low in modified UW (mUW), mUW-m, and mUW-g groups at 10, 24, and 72 hours. The mUW-m solution at low temperature was an effective and suitable solution to protect renal tissue for up to 72 h.
Lightweight application classification for network management (2007)

Traffic application classification is an essential step in the network management process to provide high availability of network services. However, network management has seen limited use of traffic classification because of the significant overheads of existing techniques. In this context we explore the feasibility and performance of lightweight traffic classification based on NetFlow records. In our experiments, the NetFlow records are created from packet-trace data and pre-tagged based upon packet content. This provides us with NetFlow records that are tagged with a high accuracy for ground-truth. Our experiments show that NetFlow records can be usefully employed for application classification. We demonstrate that our machine learning technique is able to provide an identification accuracy (≈ 91%) that, while a little lower than that based upon previous packet-based machine learning work (> 95%), is significantly higher than the commonly used port-based approach (50--70%). Trade-offs such as the complexity of feature selection and packet sampling are also studied. We conclude that a lightweight mechanism of classification can provide application information with a considerably high accuracy, and can be a useful practice towards more effective network management.
High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation (2015)

As key components of autocrine signaling, pericellular proteases, a disintegrin and metalloproteinases (ADAMs) in particular, are known to impact the microenvironment of individual cells and have significant implications in various pathological situations including cancer, inflammatory and vascular diseases. There is great incentive to develop a high-throughput platform for single-cell measurement of pericellular protease activity, as it is essential for studying the heterogeneity of protease response and the corresponding cell behavioral consequences. In this work, we developed a microfluidic platform to simultaneously monitor protease activity of many single cells in a time-dependent manner. This platform isolates individual microwells rapidly on demand and thus allows single-cell activity measurement of both cell-surface and secreted proteases by confining individual cells with diffusive FRET-based substrates. With this platform, we observed dose-dependent heterogeneous protease activation of HepG2 cells treated with phorbol 12-myristate 13-acetate (PMA). To study the temporal behavior of PMA-induced protease response, we monitored the pericellular protease activity of the same single cells during three different time periods and revealed the diversity in the dynamic patterns of single-cell protease activity profile upon PMA stimulation. The unique temporal information of single-cell protease response can help unveil the complicated functional role of pericellular proteases.
Safeguards instrument to monitor spent reactor fuel (1981)

A hand-held instrument for monitoring irradiated nuclear fuel inventories located in water-filled storage ponds has been developed. This instrument provides sufficient precise qualitative and quantitative information to be useful as a confirmatory technique to International Atomic Energy Agency inspectors, and is believed to be of potential use to nuclear fuel managers and to operators of spent-fuel storage facilities, both at reactor and away-from-reactor, and to operators of nuclear fuel reprocessing plants. Because the Cerenkov radiation glow can barely be seen by the unaided eye under darkened conditions, a night vision device is incorporated to aid the operator in locating the fuel assembly to be measured. Beam splitting optics placed in front of the image intensifier and a preset aperture select a predetermined portion of the observed scene for measurement of the light intensity using a photomultiplier (PM) tube and digital readout. The PM tube gain is adjusted by use of an internal optical reference source, providing long term repeatability and instrument-to-instrument cnsistency. Interchangeable lenses accommodate various viewing and measuring conditions.
Environment recognition for digital audio forensics using MPEG-7 and mel cepstral features. (2013)

Abstract: Environment recognition from digital audio for forensics application is a growing area of interest. However, compared to other branches of audio forensics, it is a less researched one. Especially less attention has been given to detect environment from files where foreground speech is present, which is a forensics scenario. In this paper, we perform several experiments focusing on the problems of environment recognition from audio particularly for forensics application. Experimental results show that the task is easier when audio files contain only environmental sound than when they contain both foreground speech and background environment. We propose a full set of MPEG-7 audio features combined with Mel Frequency Cepstral Coefficients (MFCCs) to improve the accuracy. In the experiments, the proposed approach significantly increases the recognition accuracy of environment sound even in the presence of high amount of foreground human speech.