gebhart/patrepeval huggingface dataset:
Nucleosides. CXXXV. Synthesis of some 9-(2-deoxy-2-fluoro-.BETA.-D-arabinofuranosyl)-9H-purines and their biological activities. (1989)

Seven purine nucleosides containing the 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl moiety were synthesized and tested for their antitumor activity. Direct condensation of 3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide (1) with N6-benzoyladenine in CH2Cl2 followed by saponification of the product afforded the adenine nucleoside (I, 2'-F-ara-A). Deamination of I with NaNO2 in HOAc gave the hypoxanthine analogue (II, 2'-F-ara-H). The 6-thiopurine nucleoside (III, 2'-F-ara-6MP) was prepared by condensation of 1 with 6-chloropurine by the mercury procedure followed by thiourea treatment and saponification of the product. Methylation of III gave the 6-SCH3 analogue (IV). Raney Ni desulfurization of III afforded the unsubstituted purine nucleoside (V, 2'-F-ara-P). Condensation of 1 with 2-acetamido-6-chloropurine by the silyl procedure afforded the protected 2-acetamido-6-chloropurine nucleoside which served as the precursor for both the guanine and 6-thioguanine nucleosides (VI, 2'-F-ara-G and VII, 2'-F-ara-TG, respectively). Thus, alkaline hydrolysis of the precursor gave VI. Thiourea treatment prior to alkaline hydrolysis gave VII. The new nucleoside, 2'-F-ara-G (VI) is found to be selectively toxic to human T-cell leukemia CCRF-CEM.
Reconfigurable Logic Gates Using Single-Electron Spin Transistors (2007)

We propose and numerically analyze novel reconfigurable logic gates using "single-electron spin transistors" (SESTs), which are single-electron transistors (SETs) with ferromagnetic electrodes and islands. The output characteristics of a SEST depend on the relative magnetization configuration of the ferromagnetic island with respect to the magnetization of the source and the drain, i.e., high current drive capability in parallel magnetization and low current drive capability in antiparallel magnetization. The summation of multiple input signals can be achieved by directly coupling multiple input gate electrodes to the SEST island, without using a floating gate. A Tucker-type inverter with a variable threshold voltage, a reconfigurable AND/OR logic gate, and a reconfigurable logic gate for all symmetric Boolean functions are proposed and simulated using the Monte Carlo method.
Digital implementation and simulation of an average current controlled switching regulator (1979)

A digital implementation of a new voltage controlled current source is described. A stability analysis was carried out and a program was developed to simulate the per­formance of this digital controller which incorporates proportional and derivative feedback to regulate the output voltage of a current step-up switching regulator. The results from the simulation program and the implemented breadboard model are presented.
Photonic crystal display materials (2010)

Opalux Incorporated has developed a technology called Photonic Ink (P-Ink). P-Ink comprises an electroactive photonic crystal which reflects a band of color that can be tuned throughout the whole visible spectrum by controlling the applied current or voltage. An overview of the P-Ink system and the latest results on this nanocomposite material will be given. In addition, results on Opalux's 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> generation P-Ink materials will be presented, with these offering significant increases in brightness, contrast, and switching speed.
Optical Non-Invasive Latent Fingerprint Lifting (2005)

Most existing latent fingerprints lifting methods are invasive and often induce deleterious side effects. Based on the optical reflection and polarization we present a completely non-invasive method to lift latent fingerprints into good quality images.
Improved Signal Chains for Readout of CMOS Imagers (2009)

An improved generic design has been devised for implementing signal chains involved in readout from complementary metal oxide/semiconductor (CMOS) image sensors and for other readout integrated circuits (ICs) that perform equivalent functions. The design applies to any such IC in which output signal charges from the pixels in a given row are transferred simultaneously into sampling capacitors at the bottoms of the columns, then voltages representing individual pixel charges are read out in sequence by sequentially turning on column-selecting field-effect transistors (FETs) in synchronism with source-follower- or operational-amplifier-based amplifier circuits. The improved design affords the best features of prior source-follower-and operational- amplifier-based designs while overcoming the major limitations of those designs. The limitations can be summarized as follows: a) For a source-follower-based signal chain, the ohmic voltage drop associated with DC bias current flowing through the column-selection FET causes unacceptable voltage offset, nonlinearity, and reduced small-signal gain. b) For an operational-amplifier-based signal chain, the required bias current and the output noise increase superlinearly with size of the pixel array because of a corresponding increase in the effective capacitance of the row bus used to couple the sampled column charges to the operational amplifier. The effect of the bus capacitance is to simultaneously slow down the readout circuit and increase noise through the Miller effect.
Identifying and quantifying architectural debt (2016)

Our prior work showed that the majority of error-prone source files in a software system are architecturally connected. Flawed architectural relations propagate defects among these files and accumulate high maintenance costs over time, just like debts accumulate interest. We model groups of architecturally connected files that accumulate high maintenance costs as architectural debts. To quantify such debts, we formally define architectural debt, and show how to automatically identify debts, quantify their maintenance costs, and model these costs over time. We describe a novel history coupling probability matrix for this purpose, and identify architecture debts using 4 patterns of architectural flaws shown to correlate with reduced software quality. We evaluate our approach on 7 large-scale open source projects, and show that a significant portion of total project maintenance effort is consumed by paying interest on architectural debts. The top 5 architectural debts, covering a small portion (8% to 25%) of each project's error-prone files, capture a significant portion (20% to 61%) of each project's maintenance effort. Finally, we show that our approach reveals how architectural issues evolve into debts over time.
Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency (2017)

Partner of sld five 1 (PSF1) is an evolutionary conserved DNA replication factor involved in DNA replication in lower species, which is strongly expressed in normal stem cell populations and progenitor cell populations. Recently, we have investigated PSF1 functions in cancer cells and found that PSF1 plays a significant role in tumour growth. These findings provide initial evidence for the potential of PSF1 as a therapeutic target. Here, we reveal that PSF1 contains an immunogenic epitope suitable for an antitumour vaccine. We analysed PSF1 peptides eluted from affinity-purified human leukocyte antigen (HLA) by mass spectrometry and identified PSF1<sub>79-87</sub> peptide (YLYDRLLRI) that has the highest prediction score using an in silico algorithm. PSF1<sub>79-87</sub> peptide induced PSF1-specific cytotoxic T lymphocyte responses such as the production of interferon-γ and cytotoxicity. Because PSF1 is expressed in cancer cell populations and highly expressed in cancer stem cell populations, these data suggest that vaccination with PSF1<sub>79-87</sub> peptide may be a novel therapeutic strategy for cancer treatment.
New inhibitors of human renin that contain novel replacements at the P2 site (1991)

A series of renin inhibitors with novel modifications at the P2 site has been prepared. Structure-activity relationships reveal that for a particular P2 fragment the in vitro potency is highly dependent on the nature of the P2' portion in addition to the P1-P1' group. The length of the P2 side chain and choice of epsilon-N P2 substitution have been found to be important for in vitro potency although the degree of unsaturation in the P2 side chain is not particularly significant. Molecular modeling studies have shown that it is possible for the P2 side chain to interact unfavorably with the P2' binding site. It has been possible to control the specificity for renin over cathepsin D by correct modification at the P2' and P1-P1' sites. Variations at the P4 site have been utilized to lower the log P values of these renin inhibitors while maintaining high potency. Compound 42, which exhibited an IC50 of 3.70 nM, log P of 2.3, and showed high specificity for renin, was selected for further studies. It was found to be very stable under neutral, acidic, and basic conditions. In simulated intestinal juice, compound 42 had a half-life of 37 min while it was virtually unaffected by simulated gastric juice after 4 h. Compound 42 produced a significant hypotensive response upon intravenous administration to the salt-depleted normotensive cynomolgus monkey.
Synthesis and Characterization of Micelle-Forming PEG-Poly(Amino Acid) Copolymers with Iron-Hydroxamate Cross-Linkable Blocks for Encapsulation and Release of Hydrophobic Drugs (2017)

Described is the development of a polymeric micelle drug delivery platform that addresses the physical property limitations of many nanovectors. The system employs triblock copolymers comprised of a hydrophilic poly(ethylene glycol) (PEG) block, and two poly(amino acid) (PAA) blocks: a stabilizing cross-linking central block, and a hydrophobic drug encapsulation block. Detailed description of synthetic strategies and considerations found to be critical are discussed. Of note, it was determined that the purity of the α-amino acid-N-carboxyanhydrides (NCA) monomers and PEG macroinitiator are ultimately responsible for impurities that arise during the polymerization. Also, contrary to current beliefs in the field, the presence of water does not adversely affect the polymerization of NCAs. Furthermore, we describe the impact of poly(amino acid) conformational changes, through the incorporation of d-amino acids to form mixed stereochemistry PAA blocks, with regard to the physical and pharmacokinetic properties of the resulting micelles.
Pharmacokinetic and Chemical Synthesis Optimization of a Potent <scp>d</scp>-Peptide HIV Entry Inhibitor Suitable for Extended-Release Delivery (2018)

Peptides often suffer from short in vivo half-lives due to proteolysis and renal clearance that limit their therapeutic potential in many indications, necessitating pharmacokinetic (PK) enhancement. d-Peptides, composed of mirror-image d-amino acids, overcome proteolytic degradation but are still vulnerable to renal filtration due to their small size. If renal filtration could be slowed, d-peptides would be promising therapeutic agents for infrequent dosing, such as in extended-release depots. Here, we tether a diverse set of PK-enhancing cargoes to our potent, protease-resistant d-peptide HIV entry inhibitor, PIE12-trimer. This inhibitor panel provides an opportunity to evaluate the PK impact of the cargoes independently of proteolysis. While all the PK-enhancing strategies (PEGylation, acylation, alkylation, and cholesterol conjugation) improved in vivo half-life, cholesterol conjugation of PIE12-trimer dramatically improves both antiviral potency and half-life in rats, making it our lead anti-HIV drug candidate. We designed its chemical synthesis for large-scale production (CPT31) and demonstrated that the PK profile in cynomolgous monkeys supports future development of monthly or less frequent depot dosing in humans. CPT31 could address an urgent need in both HIV prevention and treatment.
Human immune responses to oral micro-organisms. I. Association of localized juvenile periodontitis (LJP) with serum antibody responses to Actinobacillus actinomycetemcomitans. (1982)

The association between periodontal disease in humans and serum and salivary antibody to Actinobacillus actinomycetemcomitans strain Y4 was determined. An Elisa was used to examine anti-Y4 antibody of the IgM, IgG, IgA and IgE isotypes in serum from 127 individuals and IgA in parotid saliva. Patients diagnosed as having localized juvenile periodontitis (n = 37) had significantly higher levels and frequency of serum IgG antibodies to Y4 than all other groups. Serum and salivary IgA and serum IgE antibody levels were significantly increased in patients with both localized and generalized types of juvenile periodontitis (n = 48) when compared to all other patient groups. Specificity studies suggested that the antigenic determinants that were differentiating the group responses were unique to the Y4 organism. These results indicate that serum antibodies to Y4 may reflect an infectious process with this micro-organism and that these responses may provide some diagnostic value in delineating different types of periodontal diseases.
Logic Gates Made of N-Channel JFETs and Epitaxial Resistors (2008)

Prototype logic gates made of n-channel junction field-effect transistors (JFETs) and epitaxial resistors have been demonstrated, with a view toward eventual implementation of digital logic devices and systems in silicon carbide (SiC) integrated circuits (ICs). This development is intended to exploit the inherent ability of SiC electronic devices to function at temperatures from 300 to somewhat above 500 C and withstand large doses of ionizing radiation. SiC-based digital logic devices and systems could enable operation of sensors and robots in nuclear reactors, in jet engines, near hydrothermal vents, and in other environments that are so hot or radioactive as to cause conventional silicon electronic devices to fail. At present, current needs for digital processing at high temperatures exceed SiC integrated circuit production capabilities, which do not allow for highly integrated circuits. Only single to small number component production of depletion mode n-channel JFETs and epitaxial resistors on a single substrate is possible. As a consequence, the fine matching of components is impossible, resulting in rather large direct-current parameter distributions within a group of transistors typically spanning multiples of 5 to 10. Add to this the lack of p-channel devices to complement the n-channel FETs, the lack of precise dropping diodes, and the lack of enhancement mode devices at these elevated temperatures and the use of conventional direct coupled and buffered direct coupled logic gate design techniques is impossible. The presented logic gate design is tolerant of device parameter distributions and is not hampered by the lack of complementary devices or dropping diodes. In addition to n-channel JFETs, these gates include level-shifting and load resistors (see figure). Instead of relying on precise matching of parameters among individual JFETS, these designs rely on choosing the values of these resistors and of supply potentials so as to make the circuits perform the desired functions throughout the ranges over which the parameters of the JFETs are distributed. The supply rails V(sub dd) and V(sub ss) and the resistors R are chosen as functions of the distribution of direct-current operating parameters of the group of transistors used.
Virulence mechanisms of Moraxella in the pathogenesis of infection (2009)

Recent advances have allowed a more detailed picture of the processes involved in bacteria-host cell interactions, the cause of inflammatory processes and specific host defense responses against the intriguing species Moraxella.
Wavelet analysis of dynamic effects of atmospheric turbulence on IR digital imagery (1996)

A wavelet transform method for analyzing the dynamic effects of atmospheric turbulence on infrared digital imagery is presented. Typical results are illustrated by applying the method to simulated turbulence induced distortions and to data from field experiments. Comparisons of this method to the more traditional short-time Fourier transform and long exposure (non-dynamic) atmospheric modulation transfer function (AMTF) methods are made to show the utility of the technique.
CMOS-Free Magnetic Domain Wall Leaky Integrate-and-Fire Neurons with Intrinsic Lateral Inhibition (2020)

Spintronic devices, especially those based on motion of a domain wall (DW) through a ferromagnetic track, have received a significant amount of interest in the field of neuromorphic computing because of their non-volatility and intrinsic current integration capabilities. Many spintronic neurons using this technology have already been proposed, but they also require external circuitry or additional device layers to implement other important neuronal behaviors. Therefore, they result in an increase in fabrication complexity and/or energy consumption. In this work, we discuss three neurons that implement these functions without the use of additional circuitry or material layers.
Preliminary experiments of a miniature robotic system for tooth ablation using ultra-short pulsed lasers (2013)

As a preliminary step to achieve a long-term goal of developing an automatic dental preparation system for clinical operations, we design and build a miniature robotic system which can manipulate a laser beam to move in three dimensional spaces to remove hard tissue from a target tooth. The dental preparation requires the robotic system to own high accuracy, high ablation speed and small size. A 2D galvanometer scanners module is integrated to meet the requirement of a high moving speed of the laser focus. A closed-loop system based on a miniature-sized voice-coil motor and a grating ruler are developed to realize the accurate control of the focus. The overall size of the developed prototype is 108mm×56mm×43mm, which is small enough to be used in close proximity to a patient's mouth. The prototype has been tested by using two different kinds of laser generators, i.e., a nanosecond laser and a picosecond laser. The experiment results show that the robotic system can provide high moving speed of 1000mm/s with good shape accuracy. From the results, we found that nanosecond laser beam can be controlled to ablate zirconia and aluminum, but not suitable to ablate tooth because of tissue carbonization. By selecting suitable parameters of the picosecond laser generator, a target tooth could be ablated to produce a cylinder shape without carbonization. Limitations of the prototype are identified according to the experiment results.
Thymus-bound: the many features of T cell progenitors (2011)

T cells are unique in that they begin their development as a progenitor within the bone marrow but complete their differentiation within the thymus. Furthermore, long-term T-lymphopoiesis requires a continuous supply of thymus-bound progenitors derived from the bone marrow. The critical role for T cells is clearly observed in individuals with genetic or acquired immunodeficiencies or those having undergone hematopoietic stem cell transplantation. Here, we review the work done by several groups aimed at characterizing the earliest T-lineage progenitors (ETPs), in mouse and human, found within the thymus, in addition to the long-sought after thymus-colonizing progenitor, which makes its journey from the bone marrow via the bloodstream into thymus. The characterization of these progenitors may herald therapeutic insight into the restoration of T cells in immunodeficient individuals.
ChemInform Abstract: Preparation of Void‐Free Calcium Phosphate Glass‐Ceramics. (1989)

Abstract The formation of voids observed during the crystallization of calcium phosphate glasses is attributed to an increase in density.
Algorithms for merged indexes. (2007)

Merged indexes are B-trees that contain multiple traditional indexes and interleave their records based on a common sort order. In relational databases, merged indexes implement “master-detail clustering ” of related records, e.g., orders and order details. Thus, merged indexes shift de-normalization from the logical level of tables and rows to the physical level of indexes and records, which is a much more appropriate place for it. For object-oriented applications, clustering can reduce the I/O cost for joining rows in related tables to a fraction compared to traditional indexes, with additional beneficial effects on buffer pool requirements. Prior research has covered merged indexes without providing much guidance for their implementation. Enabling the design proposed here is a strict separation of B-tree and index into two layers of abstraction. In addition, this paper provides algorithms for (i) concurrency control and recovery including locking of individual keys and of complex objects, for (ii) data definition operations including adding and removing individual indexes in a merged index, for (iii) update operations including bulk insertions and bulk deletions, for (iv) enforcement of relational integrity constraints from uniqueness constraints to foreign key constraints, and for (v) query processing including caching in query execution plans dominated by nested iteration and index navigation. Within such a merged index, the set of tables, views, and indexes can evolve without restriction. The set of clustering columns can also evolve freely. A relational query processor can search and update index records just as in traditional indexes. With these abilities, the proposed design may finally bring general masterdetail clustering and its performance advantages to traditional databases. 1
Novel low-molecular-weight hydrogelators based on 2′-deoxyuridine (2003)

We have synthesized low-molecular-weight, triazole ring-appended 2'-deoxyuridine hydrogelators that gelate pure water at a concentration as low as 0.2 wt% and these compounds display different aggregation and network structures as evidenced by their SEM images, FTIR spectra and minimum gel concentrations.
Sample Efficient Adaptive Text-to-Speech (2018)

We present a meta-learning approach for adaptive text-to-speech (TTS) with few data. During training, we learn a multi-speaker model using a shared conditional WaveNet core and independent learned embeddings for each speaker. The aim of training is not to produce a neural network with fixed weights, which is then deployed as a TTS system. Instead, the aim is to produce a network that requires few data at deployment time to rapidly adapt to new speakers. We introduce and benchmark three strategies: (i) learning the speaker embedding while keeping the WaveNet core fixed, (ii) fine-tuning the entire architecture with stochastic gradient descent, and (iii) predicting the speaker embedding with a trained neural network encoder. The experiments show that these approaches are successful at adapting the multi-speaker neural network to new speakers, obtaining state-of-the-art results in both sample naturalness and voice similarity with merely a few minutes of audio data from new speakers.