gebhart/patrepeval huggingface dataset:
From Animalcules to an Ecosystem: Application of Ecological Concepts to the Human Microbiome (2012)

The human body is inhabited by billions of microbial cells and these microbial symbionts play critical roles in human health. Human-associated microbial communities are diverse, and the structure of these communities is variable across body habitats, through time, and between individuals. We can apply concepts developed by plant and animal ecologists to better understand and predict the spatial and temporal patterns in these communities. Due to methodological limitations and the largely unknown natural history of most microbial taxa, this integration of ecology into research on the human microbiome is still in its infancy. However, such integration will yield a deeper understanding of the role of the microbiome in human health and an improved ability to test ecological concepts that are more difficult to test in plant and animal systems.
T CELL SUBSETS INVOLVED IN LETHAL GRAFT-VERSUS-HOST DISEASE DIRECTED TO IMMUNODOMINANT MINOR HISTOCOMPATIBILITY ANTIGENS (1994)

T cell responses to multiple minor histocompatibility antigens are governed by the complex phenomenon of immunodominance, as demonstrated clearly in the generation of CTL in the C57BL/6By (B6) anti-BALB.B strain combination. Immunodominance has also been found in lethal graft-versus-host disease (GVHD) responses directed to BALB.B minor histocompatibility antigens, after transplantation of B6 T cells and T cell-depleted bone marrow to irradiated (825 cGy) recipients of either the BALB.B or CXB recombinant inbred strains. However, previous results indicated that the hierarchy of immunodominance in GVHD differed from that predicted from the in vitro CTL studies. Lethal GVHD was observed in BALB.B, CXBE, CXBI, and CXBJ recipients, but not in CXBG and CXBK recipients, the latter 2 strains expressing immunodominant antigens for CTL generation. A major hypothesis to account for these discordant observations is that GVHD reflected the activity of CD4+, but not CD8+, T cell subsets, in contrast to only the in vitro cytolytic potential of CD8+ T cells. Therefore, the current study was undertaken to assess the GVHD potential of both T cell subsets in the B6-->BALB.B, CXBE, CXBI, and CXBJ strain combinations and to analyze the early GVHD responses in the B6-->CXBG and CXBK strains. The results indicate that lethal GVHD responses in the B6-->BALB.B combination can be mediated by either CD4+ T cells or CD4-dependent CD8+ T cells; a similar observation was made with the B6-->CXBI strain combination. Lethal GVHD in the B6-->CXBE strain combination is mediated only by CD4-dependent CD8+ T cells, whereas GVHD in the B6-->CXBJ combination involves either CD4+ T cells alone or CD4-independent CD8+ T cells. In the B6-->CXBG and CXBK recipients, which do not develop lethal GVHD, the early phases of a GVHD response was detected with involvement of both CD4+ and CD8+ T cells. These results indicate that CD8+ T cells are active at some level in all of the strain combinations tested, that CD4+ T cells do not account for the GVHD immunodominant response in the CXBE recipients, and that the failure to obtain extensive clinical disease in the CXBG and CXBK strains is not due to a lack of a graft-versus-host response.
Angiotensin II Receptor Blockade After Myocardial Infarction in Rats (1992)

Journal of Cardiovascular Pharmacology™ is a peer reviewed, multidisciplinary journal that publishes original articles and pertinent review articles on basic and clinical aspects of cardiovascular pharmacology. Appropriate subjects include new drug development and evaluation, physiological and pharmacological bases of drug action, metabolism, drug interactions and side effects, clinical results with new and established agents and novel methods. The focus is on pharmacology in its broadest applications, incorporating not only traditional approaches, but new approaches to the development of pharmacological agents and the prevention and treatment of cardiovascular diseases.
A Review of Methods for the Determination of Reduced Sulfur Compounds (RSCs) in Air (2009)

The importance of reduced sulfur compounds (RSCs) in air is well-known for its significant effect on global atmospheric chemistry and malodor and quality of life. In this review, methodological approaches commonly employed for the analysis of RSCs such as hydrogen sulfide, methane thiol, dimethyl sulfide, carbon disulfide, and dimethyl disulfide in air are described. To this end, we focus on gas chromatography (GC) because it is the most feasible, frequently used, and widely accepted approach for the analysis of RSC in air. The advantages and possible limitations related to sampling and/or preconcentration methods are also discussed. The relative performance of different GC-based detection methodologies is evaluated in terms of basic quality assurance. Some alternative methods (i.e., other than GC) that deal with the determination of RSCs in air matrices are also discussed briefly. Finally, this review addresses the methodological developments of RSC analysis by highlighting current limitations and future developments.
Formation Equilibrium of a Copper(II)-Binuclear Complex of a New Pyridyl-Containing Tetraoxo Octaaza Macrocyclic Ligand and Its Polarographic Reduction Behavior (1995)

Abstract We have studied the complexation reaction of a newly synthesized 26-membered octaaza macrocycle, 3,6,9,17,20,23,29,30-octaazatricyclo[23.3.1.1.11,15]triaconta-1(29),11,13,15(30),25,27-hexaene-2,10,16,24-tetraone (TOBP, L), with a Cu(II) ion by pH-metric titration. It accomodates two copper(II) ions in its macrocyclic cavity with a simultaneous dissociation of the four amide protons to yield a binuclear complex designated as [Cu2H−4L]°. The formation constant of [Cu2H−4L]°, KCu2H−4L ( = [Cu2H−4L°][H+]4/[Cu2+]2[L]), was found to be (3.5 ± 0.2) × 10−12 mol2 dm−6. At the dropping mercury electrode the Cu(II) binuclear complex gave two reduction steps of equal height in a borate buffer solution, corresponding to the following reduction scheme:
Inhibitory effect of 10-hydroxydecanoic acid on lipopolysaccharide-induced nitric oxide production via translational downregulation of interferon regulatory factor-1 in RAW264 murine macrophages (2013)

Toll-like receptors (TLRs) play a critical role in innate immunity by recognizing pathogen-associated molecular patterns. Various environmental materials including lipids may affect TLR signaling and modulate innate immune responses. We previously reported that 10-hydroxy-trans-2-decenoic acid (10H2DA) inhibits lipopolysaccharide (LPS)-induced interleukin (IL)-6 and nitric oxide (NO) production via inhibiting NF-κB activation. In this study, we investigated the effect of 10-hydroxydecanoic acid (10HDA), a saturated fatty acid of 10H2DA, on LPS-induced cytokines/chemokines and NO production. 10HDA inhibited LPS-induced NO production, but not tumor necrosis factor-α or IL-6 production. LPS-induced activation of interferon (IFN)-stimulated response element, but not NF-κB, was inhibited by 10HDA. Phosphorylation of STAT1 and STAT2 was not affected, but IFN-regulatory factor (IRF)-1 production was significantly reduced by 10HDA. The LPS-induced increase of IRF-1 mRNA, however, was not affected by 10HDA. We found that IRF-1 mRNA level in the polysomal fraction was significantly decreased by 10HDA. Further, LPS-induced phosphorylation of Akt and 4E-BP1, which control mRNA translation, was markedly decreased. These results suggest that 10HDA inhibited LPS-induced NO production through inhibiting IRF-1 translation. These findings elucidate a novel mechanism for anti-inflammatory activity of medium-chain fatty acid 10HDA.
High‐frequency trading order cancellations and market quality: Is stricter regulation the answer? (2020)

Abstract High‐frequency traders (HFTs) frequently submit, cancel and resubmit trading orders in an attempt to stay in front of the queue. This study shows that HFTs cancel a large number of limit orders within 50 ms in order to create arbitrage opportunities in the Australian Stock Exchange (ASX). We find that HFTs generate substantial profits after transaction costs and are capable of extending their strong profitability generating record in the future. Our empirical results indicate that institutional investors lacking speed are more likely to experience higher execution costs. We propose the introduction of batch auctions, one per 50 ms of trading, to impose a queuing risk for HFTs leading to positive market quality effects.
Transformation of Gaussian to coherent uniform beams by inverse-Gaussian transmittive filters (1998)

Several plano-convex aluminum thin films, ~30 nm thick in the center and ~2 mm in diameter, were deposited on microscope cover slides to function as inverse-Gaussian transmittive filters. By placing one of these filters in front of the Gaussian He-Ne laser, we can modify the beam intensity profile in the downstream direction. To yield a uniform beam, the position of the filter must be aligned in the transverse plane for maximum intensity at the output of the filter. These filters are easy to fabricate and are inexpensive. Most important, they can help produce collimated phase-coherent uniform beams, which are useful in high-precision fringe-analysis techniques.
Persistent messages in local transactions (1998)

We present a new model for handling messages and state in a distributed application that we call Messages in Local Transactions (MLT). Under this model, messages and data are not lost after crashes, and all sends and receives are performed in local transactions. The model is unique in that it guarantees consistent recovery without the complex- ity or overhead of other recovery techniques. Applications using MLT do not need to coordinate checkpoints, track causal dependencies, or perform distributed commits. We show that MLT can be implemented using any reliable pro- tocol. Finally, we describe our implementation of Vista- grams, a system based on the MLT model. We show that Vistagrams are just as fast as traditional messages, despite the recoverability they offer. The efficiency of our model and our Vistagrams implementation is enabled by the avail- ability of fast stable storage, such as the reliable memory provided by the Rio file cache.
Nuclear Polyadenylate-Binding Protein (1985)

Polyadenylate-binding activity can be detected in eluates from sodium dodecyl sulfate gels by a nitrocellulose filter-binding assay. Nuclear extracts from rat liver show a single peak of binding activity at 50 to 55 kilodaltons; cytoplasmic extracts show a single peak at 70 to 80 kilodaltons, corresponding to a 75-kilodalton protein previously described. Similar results are obtained with yeast and mouse fibroblasts, indicating a high degree of conservation of both nuclear and cytoplasmic polyadenylate-binding proteins. The activity from rat liver nuclei has been purified 125-fold on the basis of specific binding to polyadenylate and shows two main bands in sodium dodecyl sulfate gels at 53 and 55 kilodaltons.
Third harmonic generation in the short-wavelength UV range by a single plasmonic nanostructure (2016)

The nonlinear optical interaction of laser radiation with nanostructures formed in gold and aluminium nanofilms has been experimentally studied. It is shown that, despite the high susceptibility χ3 of aluminium in comparison with gold, the third-harmonic generation efficiency at a wavelength of 260 nm is much higher for the nanostructures formed in a gold nanofilm because of the efficient excitation of a localised plasmon resonance at the fundamental frequency.
Colon Carcinoma Cell Interaction With Liver Sinusoidal Endothelium Inhibits Organ-Specific Antitumor Immunity Through Interleukin-1-Induced Mannose Receptor in Mice (2010)

ICAM-1-induced tumor COX-2 decreased antitumor activity during hepatic metastasis through IL-1-induced ManR. ManR constituted a common mediator for prometastatic effects of IL-1, COX-2, and ICAM-1. A rise in hepatic IFN-gamma/IL-10 ratio and antitumor cytotoxicity by way of ManR blockade is consistent with the antimetastatic effects of IL-1, COX-2, and ICAM-1 inhibitors. These data support ManR and ManR-stimulating factors as targets for hepatic colorectal metastasis therapy.
Proximity effects in superconductor-ferromagnet heterostructures (2005)

The proximity effect at superconductor-ferromagnet interfaces produces damped oscillatory behavior of the Cooper pair wave function within the ferromagnetic medium. This is analogous to the inhomogeneous superconductivity, predicted long ago by Fulde and Ferrell (P. Fulde and R. A. Ferrell, 1964, ``Superconductivity in a strong spin-exchange field,'' Phys. Rev. 135, A550--A563), and by Larkin and Ovchinnikov (A. I. Larkin and Y. N. Ovchinnikov, 1964, ``Inhomogeneous state of superconductors,'' Zh. Eksp. Teor. Fiz. 47, 1136--1146 [Sov. Phys. JETP 20, 762--769 (1965)]), and sought by condensed-matter experimentalists ever since. This article offers a qualitative analysis of the proximity effect in the presence of an exchange field and then provides a description of the properties of superconductor-ferromagnet heterostructures. Special attention is paid to the striking nonmonotonic dependence of the critical temperature of multilayers and bilayers on the ferromagnetic layer thickness as well as to the conditions under which ``$\ensuremath{\pi}$'' Josephson junctions are realized. Recent progress in the preparation of high-quality hybrid systems has permitted the observation of many interesting experimental effects, which are also discussed. Finally, the author analyzes the phenomenon of domain-wall superconductivity and the influence of superconductivity on the magnetic structure in superconductor-ferromagnet bilayers.
The Use of Interferometric Radiance Measurements for Sounding the Atmosphere (1979)

It is shown that the partial interferogram measurement technique, originally developed to separate the trace gas emissions from a spectral signal dominated by background radiation (from the earth's surface) and emissions from major constituents (H2O and CO2), has application to the vertical sounding problem. The interferometric technique will enable relatively high vertical temperature profile resolution to be achieved and will provide absolute accuracies of temperature approaching, and at same levels exceeding, 1°C.
Learning the structure of manifolds using random projections (2007)

We present a simple variant of the k-d tree which automatically adapts to intrinsic low dimensional structure in data. 1
Overview of Carbon Capture Technology: Microalgal Biorefinery Concept and State-of-the-Art (2019)

The impending danger of climate change and pollution can now be seen on the world panorama. The concentration of CO2, the most important Green House Gas (GHG), has reached to formidable levels. Although carbon capture and storage (CCS) methods have been largely worked upon, they are cumbersome in terms of economy and their long term environmental safety raises a concern. Alternatively, bio-sequestration of CO2 using microalgal cell factories has emerged as a promising way of recycling CO2 into biomass via photosynthesis which in turn could be used for the production of bioenergy and other value-added products. Despite enormous potential, the production of microalgae for low-value bulk products and bulk products such as biofuels, is heretofore, not feasible. To achieve economic viability and sustainability, major hurdles in both, the upstream and downstream processes have to be overcome. Recent technoeconomic analyses and life-cycle assessments of microalgae-based production systems have suggested that the only possible way for scaling up the production is to completely use the biomass in an integrated biorefinery set-up wherein every valuable component is extracted, processed and valorized. This article provides a brief yet comprehensive review of the present carbon sequestration and utilization technologies, focusing primarily on biological CO2 capture by microalgae in the context of bio-refinery. The paper discusses various products of microalgal biorefinery and aims to assess the opportunities, challenges and current state-of-the-art of microalgae-based CO2 bioconversion, which are essential to the sustainability of this approach in terms of the environment as well as the economy.
MOBIT, A Small Wheel - Track - Leg Mobile Robot (2006)

MOBIT is a small mobile robotic platform that combines wheels, legs and tracks to move with different locomotion modes in both indoor and outdoor environments. Utilizing its independent actuated arms up and down, many desired locomotion modes can be realized, which makes the robot good adaptability and high capability of obstacle negotiation. To validate the concept, the first prototype developed measures 70 cm times 60 cm with the articulations up and has a body clearance of 7.8 cm to 37.8 cm depending on the position of the articulations. To control the different components of the robot, the embedded control system is used and the teleoperation makes the robot work practice. The effectiveness of the developed mobile robot is confirmed by experiments such as climbing stairs, traversing steps and posture recovering when tipped over
Kinetic and ultrastructural studies of interactions of target-sensitive immunoliposomes with herpes simplex virus (1988)

The bilayer phase of dioleoylphosphatidylethanolamine (PE) can be stabilized with palmitoyl-IgG monoclonal antibody to the glycoprotein gD of the herpes simplex virus (HSV). Interactions of PE immunoliposomes with the target virions were characterized by analyzing the kinetics of lipid mixing, by liposomal content release, and by ultrastructural studies. As revealed by a resonance energy transfer assay, lipid mixing between PE immunoliposomes and virions was very rapid, with a second-order rate constant (kapp) of 0.173 (min)-1 (microgram/mL virus)-1. In comparison, content release from PE immunoliposomes was much slower and exhibited multiple-phase, mixed-order kinetics, indicating that liposome destabilization involved fusion of liposomes with HSV. The extent and the apparent rate of liposome destabilization were strongly dependent on liposome concentration. This was evident by the fact that only one to two liposomes were destabilized by each virus particle at low liposome concentration (0.1 microM). For higher liposome concentrations (1-10 microM), this value was 35-104. This finding implies that collision among the virus-bound liposomes is essential for the eventual collapse of PE immunoliposomes to form the hexagonal (HII) equilibrium phase which was observed using freeze-fracture electron microscopy. Studies employing soluble gD, immobilized on latex beads, indicated that a multivalent antigen source is essential for PE immunoliposome destabilization. Immediately after liposome-virus binding, fusion of liposome with the viral membrane then follows. Upon growth of the fusion complexes, which increase to 35-104 liposomes for each virus, an eventual collapse of the structure results, driving PE to its equilibrium structure of HII phase.
A Reactive Scheduling Strategy Applied On MapReduce OLAM Operators System (2012)

The combination of Data warehousing and data analysis techniques such as OLAP (Online Analytic Processing) and data mining through the Hadoop framework is an innovative way to treat large volumes of data. However, this way poses serious scheduling and combining tasks issues that bring more challenges. In this paper, we propose strategies to answer these questions, namely parallel OLAM (Online Analytic Mining) MapReduce Operators and a Reactive Scheduling Policy. OLAM MapReduce Operators divide jobs into two parts, the first includes all the operators that are used to create an OLAM CUBE and the second includes those who exploit the cube by data mining algorithms. The proposed policy coordinates the workflow generated by these operators, relying on model-based events. Our simulation experience shows that our strategy has a cumulative force that it reduces the execution time of the entire cluster at each request.
cAMP controls human renin mRNA stability via specific RNA‐binding proteins (2004)

It is now recognized that post-transcriptional mechanisms are pivotal to renin production. These involve factors that modulate renin mRNA stability. In 2003 new data has emerged from work in Australia and Germany that has identified several of the, as many as, 20 or so proteins involved. These include CP1 (hnRNP E1), HuR, HADHB, dynamin, nucleolin, YP-1, hnRNP K and MINT-homologous protein. Cyclic AMP (cAMP) is a crucial regulator of renin secretion as well as transcriptional and post-transcriptional control of expression. Many of the RNA-binding proteins that were identified responded to forskolin, increasing in amount by two to 10-fold. The cAMP mechanisms that regulate renin mRNA target, at least in large part, other genes that presumably encode some of these proteins. The increase in the expression of these then facilitates, sequentially, renin mRNA stabilization and destabilization. Our data, using a battery of different techniques, confirm that CP1 and HuR stabilize renin mRNA, whereas HADHB causes destabilization. These proteins target cis-acting C-rich sequences (in the case of CP1) and AU-rich sequences (HuR) in the distal region of the 3'-untranslated region of renin mRNA. We found HADHB was enriched in juxtaglomerular cells and that that within Calu-6 cells HADHB, HuR and CP1 all localized in nuclear subregions, as well as cytoplasm (HADHB and CP1) and mitochondria (HADHB) commensurate with the role each plays in control of renin mRNA stability. The specific proteins that bind to human renin mRNA have begun to be revealed. Cyclic AMP upregulates the binding of several of these proteins, which in turn affect renin mRNA stability and thus overall expression of renin.
An Internet Of Things-Based Weight Monitoring System For Honey (2017)

Bees play a vital role in pollination. This paper focuses on the weighing process of honey. Honey is usually stored at the comb in a hive. Bee farmers brush bees away from the comb and then collect honey, and the collected honey is weighed afterward. However, such a process brings strong negative influences on bees and even leads to the death of bees. This paper therefore presents an Internet of Things-based weight monitoring system which uses weight sensors to measure the weight of honey and simplifies the whole weighing procedure. To verify the system, the weight measured by the system is compared to the weight of standard weights used for calibration by employing a linear regression model. The R<sup>2</sup> of the regression model is 0.9788, which suggests that the weighing system is highly reliable and is able to be applied to obtain actual weight of honey. In the future, the weight data of honey can be used to find the relationship between honey production and different ecological parameters, such as bees’ foraging behavior and weather conditions. It is expected that the findings can serve as critical information for honey production improvement.
Power and Information Transmission to Implanted Medical Device Using Ultrasonic (2001)

Using ultrasonic, we propose here a novel method of transmitting power and information to implanted medical equipment. The proposed system is composed of two piezo oscillators and has the following functions: transmission of power and control information to an implanted device, and transmission of the information acquired by an implanted device to the outside of a living body. With amplitude shift keying (ASK), 9.5 Kbps is obtained for the proposed information transmission system.