gebhart/patrepeval huggingface dataset:
Cranberry proanthocyanidins associate with low‐density lipoprotein and inhibit <i>in vitro</i> Cu<sup>2+</sup>‐induced oxidation (2001)

Abstract Antioxidant activity of six fractions of cranberry phenolic compounds was determined by inhibition of Cu 2+ ‐induced low‐density lipoprotein (LDL) oxidation. The phenolic composition of each fraction was determined by high‐performance liquid chromatography. The phenolic fractions were mixed with aliquots of modified human serum prior to LDL isolation. The serum was modified to remove very‐low‐density lipoprotein and chylomicrons that may bind phenolic compounds. Only fractions 5 and 6 that contained proanthocyanidins (PAs) significantly increased the lag time of LDL oxidation, and the lag time for fraction 6 was significantly higher than for fraction 5. The mass distribution of PAs in these fractions was obtained by matrix‐assisted laser desorption/ionisation time‐of‐flight mass spectrometry, a technique that allows rapid characterisation of the molecular weight distribution in mixtures of oligomeric compounds. Fraction 5 contained trimers through heptamers, whereas fraction 6 contained pentamers through nonamers. In addition, fraction 6 contained PA oligomers with more doubly linked, A‐type interflavan bonds. Results indicate that PAs specifically associate with LDL in modified serum and increase the lag time of Cu 2+ ‐induced oxidation. Differences between fractions 5 and 6 in PA structure and effects on LDL oxidation suggest that the degree of polymerisation and the nature of the interflavan bond influence antioxidant properties. © 2001 Society of Chemical Industry
Kinematic and Dynamic Analysis of the 2-DOF Spherical Wrist of Orthoglide 5-axis (2009)

This paper deals with the kinematics and dynamics of a two degree of freedom spherical manipulator, the wrist of Orthoglide 5-axis. The latter is a parallel kinematics machine composed of two manipulators: i) the Orthoglide 3-axis; a three-dof translational parallel manipulator that belongs to the family of Delta robots, and ii) the Agile eye; a two-dof parallel spherical wrist. The geometric and inertial parameters used in the model are determined by means of a CAD software. The performance of the spherical wrist is emphasized by means of several test trajectories. The effects of machining and/or cutting forces and the length of the cutting tool on the dynamic performance of the wrist are also analyzed. Finally, a preliminary selection of the motors is proposed from the velocities and torques required by the actuators to carry out the test trajectories.
Transdermal apomorphine permeation from microemulsions: A new treatment in Parkinson's disease (2004)

We studied absorption, efficacy, and tolerability in Parkinson's disease (PD) of a new preparation of apomorphine included in a microemulsion and administered by transdermal route (Apo-MTD). Twenty-one PD patients were treated with levodopa plus oral dopamine-agonists (T0), with levodopa alone (T1), finally with levodopa plus Apo-MTD (T2). Apo-MTD provided therapeutic plasma levels for many hours, improved Unified Parkinson's Disease Rating Scale III scores, and reduced total duration of off periods compared to T0 and T1. We concluded that Apo-MTD is absorbed and demonstrates clinical efficacy and long action. Therefore, it seems a promising add-on treatment for uncontrolled prolonged off phases in PD patients, but chronic tolerability needs further study.
Clinical Pharmacokinetics and Pharmacodynamics of Risankizumab in Psoriasis Patients (2019)

Risankizumab is a humanized immunoglobulin (Ig) G1 monoclonal antibody developed and approved for the treatment of moderate-to-severe plaque psoriasis at a dose of 150 mg administered subcutaneously at weeks 0 and 4, and every 12 weeks thereafter. Ongoing trials are investigating the use of risankizumab in other inflammatory autoimmune diseases. Risankizumab exhibits linear pharmacokinetics when administered intravenously (0.01 mg/kg-1200 mg) or subcutaneously (0.25 mg/kg-300 mg), with a long terminal half-life of approximately 28 days. Following subcutaneous administration, peak plasma concentration was reached approximately 3-14 days after dosing, with an estimated bioavailability of 89%. Population pharmacokinetic analyses identified bodyweight, high titers of antidrug antibodies occurring in < 2% of evaluated subjects, baseline serum albumin, baseline high-sensitivity C-reactive protein, and baseline serum creatinine to be statistically correlated with risankizumab clearance, but none of them had a clinically meaningful impact on risankizumab efficacy in psoriasis patients following the clinical dosing regimen. Exposure-response analyses in psoriasis patients demonstrated that the maximum efficacy was achieved with the clinically approved regimen and there was no apparent correlation between risankizumab exposure and safety. A dedicated drug interaction cocktail study in patients with psoriasis demonstrated a lack of therapeutic protein-drug interaction potentials for risankizumab and various cytochrome P450 substrates. In this article, we review the clinical pharmacology data available to date for risankizumab, which supported the clinical development program and ultimately regulatory approvals for risankizumab in the treatment of patients with moderate-to-severe plaque psoriasis.
Finite precision error analysis of neural network electronic hardware implementations (2002)

The high speed desired in the implementation of many neural network algorithms, such as backpropagation learning in multilayer perceptrons (MLPs), may be attained through the use of finite-precision hardware. This finite precision hardware, however, is prone to errors. A method of theoretically deriving and statistically evaluating this error is presented. This could be used as a guide to the details of hardware design and algorithm implementation. The authors describe the derivation of the techniques involved, as well as the details of the backpropagation example. The intent is to provide a general framework by which most neural network algorithms under any set of hardware constraints may be evaluated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Prolactin in clinical practice (1976)

ISOLATION of human prolactin and the development of highly sensitive and specific radioimmunoassays have allowed precise quantitation of serum prolactin concentrations in humans. Although changes in prolactin secretion have been described in a variety of physiologic and pathologic conditions, our understanding of the physiologic effects of prolactin is scant. Only the obligatory role of prolactin in lactation has been established. Since random serum prolactin concentrations are only slightly lower in normal men than in normal women, prolactin may have physiologic effects unrelated to lactation. The kidney<sup>1</sup>and the adrenal<sup>2</sup>have been suggested as target organs for prolactin action. Further investigative efforts are required to explore the implications of these and other possible physiologic effects of prolactin in man. <h3>Regulation of Prolactin Secretion</h3><h3>Prolactin-Inhibitory Factor (PIF).—</h3> Prolactin secretion is primarily under tonic hypothalamic inhibitory control (Figure). Although a specific PIF has yet to be isolated, the importance of this
Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer (2016)

Metastatic breast cancer is an incurable disease and identification of novel therapeutic opportunities is vital. Triple-negative breast cancer (TNBC) frequently metastasizes and high levels of activated p90RSK (RSK), a downstream MEK-ERK1/2 effector, are found in TNBC. We demonstrate, using direct pharmacologic and genetic inhibition of RSK1/2, that these kinases contribute to the TNBC metastatic process in vivo Kinase profiling showed that RSK1 and RSK2 are the predominant kinases targeted by the new inhibitor, which is based on the natural product SL0101. Further evidence for selectivity was provided by the observations that silencing RSK1 and RSK2 eliminated the ability of the analogue to further inhibit survival or proliferation of a TNBC cell line. In vivo, the new derivative was as effective as the FDA-approved MEK inhibitor trametinib in reducing the establishment of metastatic foci. Importantly, inhibition of RSK1/2 did not result in activation of AKT, which is known to limit the efficacy of MEK inhibitors in the clinic. Our results demonstrate that RSK is a major contributor to the TNBC metastatic program and provide preclinical proof-of-concept for the efficacy of the novel SL0101 analogue in vivo Mol Cancer Ther; 15(11); 2598-608. ©2016 AACR.
A signal processing model of diagnostic x‐ray scatter (1986)

A model of scatter is developed from a signal processing approach. The scattering process is viewed as a nonlinear filter (NLF), which transforms a two‐dimensional signal representing phantom thickness into a two‐dimensional signal of scattered radiation. The NLF point spread function (PSF) is derived from a single scattering model, using the principles of Compton scattering and x‐ray attenuation. The PSF is characterized by three approximations: a constant geometric shape, a volume that depends on the phantom thickness, and a width that depends on the phantom‐to‐detector distance. This leads to a closed form expression for the scatter‐to‐primary ratio as a function of phantom thickness, field size, photon energy, source‐to‐phantom distance, and phantom‐to‐detector distance. The NLF model is compared with previously reported measurements using constant thickness phantoms, and discrepancies are discussed. The good agreement found between the NLF model and measured data shows that the functional dependence of scatter on the above parameters, previously only explained in terms of empirical models or Monte Carlo simulations, can be incorporated into a signal processing model.
Reactions of lithiooxazole (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of lithiooxazoleJohn C. Hodges, William C. Patt, and Cleo J. ConnollyCite this: J. Org. Chem. 1991, 56, 1, 449–452Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/jo00001a087https://doi.org/10.1021/jo00001a087research-articleACS PublicationsRequest reuse permissionsArticle Views1416Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Analyzing skill-based routing call centers using discrete-event simulation and design experiment (2004)

Call center customer service representatives (CSRs) or agents tend to have different skills. Some CSRs can handle one type of call, while other CSRs can handle other types of calls. Advances in automatic call distributors (ACDs) have made it possible to have skill-based routing (SBR) which is the protocol for online routing of incoming calls to the appropriate CSRs. At present, very little is known about SBR. We develop a discrete-event simulation model to analyze the performance of a M/sub n//M/sub n//C/K SBR environment in which incoming calls are handled in priority order and in a nonpreemptive manner. We use the design of experiment framework to conduct our analysis. We show empirically that the scenario in which agents have 2 skills is almost as efficient as the scenario where agents have all skills (resource pooling). Also, we discover that no interaction exists between call rate factors when resource pooling exists.
Chemical Biology of H<sub>2</sub>S Signaling through Persulfidation (2017)

Signaling by H<sub>2</sub>S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H<sub>2</sub>S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H<sub>2</sub>S and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.
Ferromagnetic Silicone Vascular Occlusion (1973)

From the Department of Surgery, Division of Neurosurgery, University of California School of Medicine, Los Angeles, California 90024
Mono- and Diaminocarbenes from Chloroiminium and -amidinium Salts:  Synthesis of Metal-Free Bis(dimethylamino)carbene (2004)

Bis(trimethylsilyl)mercury cleanly reacts at low temperature with chloroamidinium and -iminium chlorides, generating persistent metal-free cyclic and acyclic diaminocarbenes, as well as transient aryl-, chloro-, and hydrogenoaminocarbenes; with the latter, the corresponding olefin dimers were isolated, whereas with the former, no dimerization processes were observed.
Dielectric Barrier Discharge at Atmospheric Pressure as a Tool to Deposit Versatile Organic Coatings at Moderate Power Input (2007)

Abstract Plasma coating technologies have been demonstrated as being promising for the fabrication of bioactive and biocompatible materials, among others. Reported efforts are exclusively focused on the two‐step approaches, in which the bioactive component is first immobilized on a substrate, followed by a (vacuum) plasma polymerization treatment or vice versa. However, we believe that upon minimizing the plasma energy, numerous bioactive substances such as enzymes and nucleic acids can be immobilized directly in plasmas via copolymerization with organic precursors, or by direct entrapment in the organic polymer. Therefore, a dielectric barrier discharge was employed at atmospheric pressure and ambient temperature to deposit organic coatings with reasonable growth rates at power input and frequency values as low as possible. Two promising precursors, acetylene and pyrrole, were selected out of 22 organic monomers for full physicochemical characterization. While the acetylene polymer film shows resemblance with its vacuum plasma analogue, polypyrrole coatings produced in vacuum and atmospheric plasmas differ significantly. magnified image
Nanofiber Electrodes with Low Platinum Loading for High Power Hydrogen/Air PEM Fuel Cells (2013)

Membrane-electrode-assemblies (MEAs) were fabricated with electrospun nanofiber electrodes containing Johnson-Matthey (JM) HiSpec 4000 catalyst and a Nafion 212 membrane. MEA performance was evaluated in a hydrogen/air fuel cell, where power output was correlated with cathode Pt loading (0.029–0.107 mgPt/cm2) and changes in fuel cell temperature (60°C and 80°C), pressure (up to 3.0 atm), and feed gas flow rates. In all experiments, the nanofiber anode had a fixed Pt loading of 0.10 mg/cm2. The mass activity (0.16 A/mgPt at 0.9 V) and electrochemical surface area (∼41 m2/g) of nanofiber cathodes were very high and more power was generated from nanofiber electrode MEAs than from a conventional MEA with decal electrodes. Thus, the maximum power density for H2/air fuel cell operation at 80°C, 1 atm (ambient) pressure, 125 sccm H2, and 500 sccm air was 437 mW/cm2 for a nanofiber cathode at 0.065 mgPt/cm2 vs. 400 mW/cm2 for a decal MEA with cathode/anode Pt loadings of 0.104/0.40 mg/cm2. Similarly, an electrospun cathode with a Pt loading of 0.055 mg/cm2 produced a maximum power density of 906 mW/cm2 at 80°C and 3 atm pressure with 2000 sccm fully humidified air and 500 sccm H2.
Closed-Loop Control Methods for Interleaved DCM/CCM Boundary Boost PFC Converters (2009)

In this paper, a systematic overview of PLL-based closed-loop control methods for interleaved DCM/CCM boundary boost PFC converters is presented. It is shown that the PLL-based closed-loop methods always provide stable operation, unlike the open-loop control methods, where the only method which results in stable operation is the slave synchronization to the turn-on instant of the master with current-mode control. It is also shown that the dynamic response of the PLL-based closed-loop methods with master-slave approach and democratic approach is almost identical. Experimental results obtained on a 300-W, universal input, 400-V output, interleaved DCM/CCM boundary boost PFC prototype circuit with a dedicated controller IC utilizing a democratic, PLL-based closed-loop method is also provided.
[A correlation between food allergy, the autonomic nervous system and the central nervous system: a study of 8 patients in childhood]. (1997)

The aim of our study was demonstrate the correlation between immunoallergic system, autonomous nervous system (SNA) and central nervous system (SNC). Eight children allergic to food and with asthma, damage of handwriting, deambulation and behaviour were deprived of food allergens. The RAW (indicator of SNA activation) diminished and the respiratory flow increased. The neurologic symptomatology improved. The reintroduction of food allergens induced reappearance of asthmatic and neurologic symptomatology.
Spatial-cue-based multi-band binaural noise reduction for hearing aids (2013)

A noise reduction algorithm for binaural hearing aids is proposed in this paper. The proposed algorithm suppresses the directional interferences and diffuse noise using the interaural time difference (ITD), interaural level difference (ILD) and interaural coherence cues via the time-frequency (T-F) masking process. Furthermore, the proposed algorithm is evaluated under different specifications of ANSI-like filter banks for comprehending dominant factors in boosting the de-noise performance. Experimental results suggest that a higher resolution in low frequencies (approximately less than 1000 Hz) and a higher overlapping ratio of the filters are beneficial to de-noise performance in terms of sound quality.
A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer (2015)

This trial targets MUC-16(ecto), a novel and promising tumor-associated antigen. This will be the first time CAR T cells are injected intraperitoneally directly into the site of the tumor within the abdomen in humans. Furthermore, the ability of genetically modified cells to secrete IL-12 will potentially enhance CAR T cell persistence and modulate the tumor microenvironment. For safety purposes, an elimination gene has been incorporated into the CAR T cells to mitigate any on-target, off-tumor or other unforeseen toxicity.
AAV vector distribution in the mouse respiratory tract following four different methods of administration (2017)

Our results show that mode of AAV vector administration to the murine respiratory tract should be selected based on desired target site and skill of the researcher, and that appropriate technique selection may greatly influence experimental outcomes.
Real-time temporal segmentation of note objects in music signals (2004)

As tibial intramedullary nailing becomes the preferred treatment for tibial shaft fracture, removal of tibial nails will become more common. Removal of tibial intramedullary nails is not without complications, but a review of the literature found only one recent report of a fracture of the tibia during removal. A case report of a tibial fracture during removal of an Alta tibial nail is presented.
Essentiality of <i>clpX</i> , but Not <i>clpP</i> , <i>clpL</i> , <i>clpC</i> , or <i>clpE</i> , in <i>Streptococcus pneumoniae</i> R6 (2003)

We show by using a regulated promoter that clpX of Streptococcus pneumoniae R6 is essential, whereas clpP, clpL, clpC, and clpE can be disrupted. The essentiality of clpX was initially missed because of duplication and rearrangement in the region of the chromosome containing clpX. Depletion of ClpX resulted in a rapid loss of viability without overt changes in cell morphology. Essentiality of clpX, but not clpP, has not been reported previously.
A low-overhead self-healing embedded system for ensuring high yield and long-term sustainability of 60GHz 4Gb/s radio-on-a-chip (2012)

The available ISM band from 57-65GHz has become attractive for high-speed wireless applications including mass data transfer, streaming high-definition video and even biomedical applications. While silicon based data transceivers at mm-wave frequencies have become increasingly mature in recent years [1,2,3], the primary focus of the circuit community remains on the design of mm-wave front-ends to achieve higher data rates through higher-order modulation and beamforming techniques. However, the sustainability of such mm-wave systems when integrated in a SoC has not been addressed in the context of die performance yield and device aging. This problem is especially challenging for the implementation of mm-wave SoC's in deep sub-micron technology due to its process & operating temperature variations and limited ft / fmax with respect to the operation frequency.
Morphology control of polyester‐polyolefin blends by transesterification during processing operations in the presence of dibutyltin oxide (1997)

PE and PBT are known to be incompatible polymers. A grafted copolymer PBT-EVA has been generated as a compatibilizer in situ during the processing operation by redistributive transesterification between PBT and EVA in the presence of dibutyl tin oxide (DBTO). This copolymer has been isolated by selective extractions from PBT/EVA/DBTO (49.5/49.5/1% in weight) blend after processing in the melt. It has been evidenced by a 1H-NMR study. This copolymer presents all the resonances of PBT and EVA sequences and some others that have been assigned specificaly to grafting. To achieve these assignments, a model compound obtained by transesterification of EVA with methyl benzoate has been used. When the melt conditions enable synthesis of the grafted copolymer PBT-EVA in situ during processing operations, important changes in the morphology of PE/PBT/EVA/DBTO blends are observed. SEM analysis shows a decrease of PBT particle size and a good adhesion between the PBT and PE phase. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 65: 2457–2469, 1997