gebhart/patrepeval huggingface dataset:
Monte Carlo calculation of point-spread functions of Compton scatter cameras (1997)

A technique has been devised for independently determining the energy and spatial resolution components of the point-spread functions of electronically collimated (Compton scatter) imaging devices using a Monte Carlo method. Monte Carlo runs are performed for the device being examined, and detailed records of exact energy loss and spatial coordinates of each interaction for each particle in the simulation are made. Taking resolution parameters from the known performance of the detectors, measured data is simulated by sampling from Gaussian distributions (for both energy and position) about the exact interaction energy and position in both detectors, for each Monte Carlo history. By back-projecting cones on an event-by-event basis and calculating the closest approach of the cone to the known source point using the simulated measurement data for one of the energy and position variables and the exact interaction data for the rest of the variables, the effect of the variable in question on the point spread can be isolated. In this paper the authors present the calculations of the contribution to the point-spread function of the energy and spatial resolution in each detector for various source positions for a representative Compton camera configuration.
ChemInform Abstract: One‐Pot Synthesis of Hypervalent Iodine Reagents for Electrophilic Trifluoromethylation. (2013)

Abstract A simplified synthesis of hypervalent iodine reagents (IV) and (VI) is elaborated using trichloroisocyanuric acid for the first step instead of reported oxidants like sodium metaperiodate or tert‐butyl hypochlorite.
Designing chimeric enzymes inspired by fungal cellulosomes (2020)

Cellulosomes are synthesized by anaerobic bacteria and fungi to degrade lignocellulose via synergistic action of multiple enzymes fused to a protein scaffold. Through templating key protein domains (cohesin and dockerin), designer cellulosomes have been engineered from bacterial motifs to alter the activity, stability, and degradation efficiency of enzyme complexes. Recently a parts list for fungal cellulosomes from the anaerobic fungi (<i>Neocallimastigomycota</i>) was determined, which revealed sequence divergent fungal cohesin, dockerin, and scaffoldin domains that could be used to expand the available toolbox to synthesize designer cellulosomes. In this work, multi-domain carbohydrate active enzymes (CAZymes) from 3 cellulosome-producing fungi were analyzed to inform the design of chimeric proteins for synthetic cellulosomes inspired by anaerobic fungi. In particular, <i>Piromyces finnis</i> was used as a structural template for chimeric carbohydrate active enzymes. Recombinant enzymes with retained properties were engineered by combining thermophilic glycosyl hydrolase domains from <i>Thermotoga maritima</i> with dockerin domains from <i>Piromyces finnis</i>. By preserving the protein domain order from <i>P. finnis</i>, chimeric enzymes retained catalytic activity at temperatures over 80 °C and were able to associate with cellulosomes purified from anaerobic fungi. Fungal cellulosomes harbor a wide diversity of glycoside hydrolases, each representing templates for the design of chimeric enzymes. By conserving dockerin domain position within the primary structure of each protein, the activity of both the catalytic domain and dockerin domain was retained in enzyme chimeras. Taken further, the domain positioning inferred from native fungal cellulosome proteins can be used to engineer multi-domain proteins with non-native favorable properties, such as thermostability.
Cs halide photocathode for multi-electron-beam pattern generator (2004)

A unique approach to photocathode operation is described in this article. We utilize a relatively large bandgap CsBr photocathode material that under normal conditions would not photoemit with radiation energy less than the bandgap plus the work function. However, the material can be activated by proper UV illumination to obtain photoemission at wavelengths as long as 532nm. Photoyields as high as several hundred nA∕mW and current densities greater than 100A∕cm2 have been routinely obtained with lifetimes (50% degradation) well in excess of 200h at 257nm. The performance of the photocathode meeting all the requirements for a multi-electron-beam pattern generator will be presented.
Nickel(<scp>ii</scp>) pincer complexes demonstrate that the remote substituent controls catalytic carbon dioxide reduction (2018)

The first example of a CNC pincer ligand with a central pyridinol ligand is reported in a nickel(ii) complex. This metal complex can be protonated or deprotonated reversibly in situ to switch on or off the photocatalytic performance towards CO2 reduction. The O- substituent appears essential for catalysis.
Chip-based measurement-device-independent quantum key distribution (2020)

Modern communication strives towards provably secure systems which can be widely deployed. Quantum key distribution provides a methodology to verify the integrity and security of a key exchange based on physical laws. However, physical systems often fall short of theoretical models, meaning they can be compromised through uncharacterized side-channels. The complexity of detection means that the measurement system is a vulnerable target for an adversary. Here, we present secure key exchange up to 200 km while removing all side-channels from the measurement system. We use mass-manufacturable, monolithically integrated transmitters that represent an accessible, quantum-ready communication platform. This work demonstrates a network topology that allows secure equipment sharing which is accessible with a cost-effective transmitter, significantly reducing the barrier for widespread uptake of quantum-secured communication.
Microscopy with microlens arrays: high throughput, high resolution and light-field imaging (2012)

We demonstrate highly parallelized fluorescence scanning microscopy using a refractive microlens array. Fluorescent beads and rat femur tissue are imaged over a 5.5 mm x 5.5 mm field of view at a pixel throughput of up to 4 megapixels/s and a resolution of 706 nm. We also demonstrate the ability to extract different perspective views of a pile of microspheres.
Geometrical Parameters in Composite Repair (1995)

This paper presents a systematic investigation of the geometrical effects on composite repair. Although fiber geometry, matrix property, adhesive bonding, and reinforcing patch are important parameters in composite repair, the bond line geometry is the primary concern in this study. Various bond line configurations are investigated. The experimental results can be used for optimizing the composite repair design.
Current concepts of severe asthma (2016)

The term asthma encompasses a disease spectrum with mild to very severe disease phenotypes whose traditional common characteristic is reversible airflow limitation. Unlike milder disease, severe asthma is poorly controlled by the current standard of care. Ongoing studies using advanced molecular and immunological tools along with improved clinical classification show that severe asthma does not identify a specific patient phenotype, but rather includes patients with constant medical needs, whose pathobiologic and clinical characteristics vary widely. Accordingly, in recent clinical trials, therapies guided by specific patient characteristics have had better outcomes than previous therapies directed to any subject with a diagnosis of severe asthma. However, there are still significant gaps in our understanding of the full scope of this disease that hinder the development of effective treatments for all severe asthmatics. In this Review, we discuss our current state of knowledge regarding severe asthma, highlighting different molecular and immunological pathways that can be targeted for future therapeutic development.
Efficacy and Safety of Sodium–Glucose Co-Transporter 2 Inhibition According to Left Ventricular Ejection Fraction in DAPA-HF (2020)

ClinicalTrials.gov Identifier NCT03036124.
Purification and characterization of fertility‐associated antigen (FAA) in bovine seminal fluid (1999)

Heparin-binding proteins (HBP) recognized by a monoclonal antibody (M1) are produced by male accessory sex glands and bind to distinct regions of ejaculated bull sperm. Immunoblots of sperm proteins probed with M1 identified HBP variants of approximately 31-, 24-, and 21.5-kDa that were associated with increased fertility of bulls. The purpose of this study was to identify the 31-kDa HBP known as fertility-associated antigen (FAA). FAA was isolated by heparin-affinity chromatography and reversed-phase high performance liquid chromatography near homogeneity. Biochemical characterization indicated that FAA was an unglycosylated, basic protein. FAA protein was detected in seminal vesicle and prostate gland homogenates, and FAA extracted from sperm membranes by treatment with hypertonic media was identical biochemically to seminal fluid-derived FAA. N-terminal sequence analysis of purified FAA yielded a 26 amino acid sequence (L K I X S F N V R S F G E S K K A G F N A M R V I V) with 73% identity to a recently identified human deoxyribonuclease (DNase) I-like protein. Two internal amino acid sequences generated from lys-C digested FAA were 85% and 92% identical to the same DNase I-like protein. In conclusion, we have identified a bovine seminal heparin-binding protein that binds to sperm and is indicative of bull fertility as being similar to the family of DNase I-like proteins. These data demonstrate the presence of a novel DNase I-like protein in bull accessory sex glands and form the groundwork for the identification of a candidate genetic marker for fertility of bulls. Mol. Reprod. Dev. 54:145–153, 1999. © 1999 Wiley-Liss, Inc.
ChemInform Abstract: Ethyl Lactate as a Tunable Solvent for the Synthesis of Aryl Aldimines. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The identification and validation of novel aptamers for the diagnosis of oligodendroglioma (2018)

Oligodendroglioma account for nearly 12% of brain tumours (Jain et al., 2017). In the United Kingdom, 0.4 people per 100 000 per year are newly diagnosed with oligodendroglioma (Crocetti et al., 2012). Early diagnosis and treatment of oligodendroglioma is essential as patients given the appropriate chemotherapy survive on average nearly 8 years longer than patients given radiotherapy alone (Cairncross et al., 2014). Aptamers are short, single-stranded nucleotide sequences (DNA or RNA) that uniquely fold to form specific recognition molecules that selectively bind to a molecular target. Aptamers against targets are generated using a process called systematic evolution of ligands by exponential enrichment (SELEX). Since 2002, a number of aptamers have been identified that can selectively identify cancerous cells. These aptamers have been used both diagnostically and therapeutically against a range of different cancers, however, there are currently no aptamers specific to glioma tissue. This first part of this project was to find aptamers specific to the grade IV glioblastoma cell line U87MG. Previous studies have found aptamers that were able to distinguish U87MG from non-malignant cell lines but showed good binding to most highly tumorigenic cell lines (Cerchia et al., 2009; Aptekar et al., 2015). To ensure that highly specific aptamers were identified, a large number of negative controls were utilised, and two variants of the SELEX process were undertaken to ascertain whether the negative controls had to be selected against individually or if they could be pooled. Patient brain tumour samples will be obtained from the Brain Tumour North West (BTNW) tissue bank and aptamers specific to oligodendroglioma will be selected. These aptamers will be used to screen patient samples to determine if they can identify oligodendroglioma tissue and be of use diagnostically, therapeutically and as a drug delivery tool.
Design of task-specific optical systems using broadband diffractive neural networks (2019)

Deep learning has been transformative in many fields, motivating the emergence of various optical computing architectures. Diffractive optical network is a recently introduced optical computing framework that merges wave optics with deep-learning methods to design optical neural networks. Diffraction-based all-optical object recognition systems, designed through this framework and fabricated by 3D printing, have been reported to recognize hand-written digits and fashion products, demonstrating all-optical inference and generalization to sub-classes of data. These previous diffractive approaches employed monochromatic coherent light as the illumination source. Here, we report a broadband diffractive optical neural network design that simultaneously processes a continuum of wavelengths generated by a temporally incoherent broadband source to all-optically perform a specific task learned using deep learning. We experimentally validated the success of this broadband diffractive neural network architecture by designing, fabricating and testing seven different multi-layer, diffractive optical systems that transform the optical wavefront generated by a broadband THz pulse to realize (1) a series of tuneable, single-passband and dual-passband spectral filters and (2) spatially controlled wavelength de-multiplexing. Merging the native or engineered dispersion of various material systems with a deep-learning-based design strategy, broadband diffractive neural networks help us engineer the light-matter interaction in 3D, diverging from intuitive and analytical design methods to create task-specific optical components that can all-optically perform deterministic tasks or statistical inference for optical machine learning.
Surface and bulk laser-damage statistics and the identification of intrinsic breakdown processes (1973)

The experimental evidence presented confirms the existence of a statistical nature in the laser-induced intrinsic damage process both in the bulk and on the surfaces of transparent materials. A damage process determined by an electron-avalanche breakdown with statistical starting properties was found to be consistent with the data. The importance of irradiating only a small volume of the material in order to avoid studying inclusion-induced laser damage is discussed. In addition, a new procedure was developed to permit rapid identification of the occurrence of damage due to an intrinsic process.
Development of 45kW Laser Welding System for Continuous Finish-Rolling (2003)

High power laser welding system for continuous finish-rolling has been developed. Two stabilized 45kW laser oscillators are placed just beside a hot rolling mill. The laser beams propagate about 50m to a flying-welder that has beam focusing head and clampers for fixing the bars. With an automatic mirror alignment system, the laser beam position error is suppressed less than 1mm. We also introduced new laser welding method which uses the laser induced plasma as a secondly heat source to improve the bead depth about 30% compare to the conventional welding method.
Wavelength insensitive passive polarization converter fabricated by poled polymer waveguides (1995)

A passive TE to TM polarization mode converter is fabricated by using poled polymer waveguides. The optic axis of the poling induced waveguide is slowly rotated 90° by using a slowly varying structure of poling electrodes. Thus the polarization conversion is achieved as the guided mode propagates through the waveguide. TE to TM mode conversion is observed with a polarization extinction ratio higher than 30 dB, and the excess loss is less than 1 dB. The polarization conversion is relatively insensitive to wavelength since the device contains no periodic structures. These devices are easier to fabricate than others containing periodic structures.
A New PWM Method of a Three-Level Inverter Considering Minimum Pulse Width and Neutral Voltage Balance Control. (1993)

A new PWM method of the three-level inverter using a digital signal processor, which is useful for large capacity instantaneous current controlled GTO inverters is presented.
A policy-based approach for QoS specification and enforcement in distributed service-oriented architecture (2005)

A significant challenge of successful application of the service-oriented architecture (SOA) in large-scale distributed systems is the quality of service (QoS) management, which provides various QoS guarantee levels for concurrent clients through effective resource allocations and adaptations. In this paper, we propose a policy-based approach for specifying QoS management strategies and enforcing QoS guarantees. This approach enables easy adaptation of new business rules and adaptation to system resource changes. This approach is also effective for supporting QoS management, as demonstrated in our experiments in a publish/subscribe system.
Speed-up multi-stage non-cooperative iris recognition (2012)

Iris is tested to be the most accurate one. However, most existing methods are not designed for non-cooperative users and cannot work with off-angle or low quality iris images. In this paper, we propose a robust multi-stage feature extraction and matching approach for non-cooperative iris recognition. We developed the Speed Up Robust Feature (SURF)-like method to extract stable feature points, used Gabor Descriptor method for local feature description, and designed the multi-stage feature extraction and matching scheme to improve the recognition accuracyand speed. The experimental results show that the proposed method can not only improve the process speed but also achieve better recognition accuracy.
Linear Arrays of Microchannel Plasmas in Monolithic $ \hbox{Al/Al}_{2}\hbox{O}_{3}$ Sheets (2011)

Linear microplasmas have been produced within rectangular channels, 75 × 75 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in cross section and 7 cm in length. Arrays of such channels have been fabricated in single sheets of 127-μm-thick aluminum foil by a photolithographic step and an electrochemical process. Arrays comprising 20 parallel channels have been operated in the rare gases, N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , and air at pressures in the 100-760-Torr interval.
Accelerated High-Resolution Differential Ion Mobility Separations Using Hydrogen (2011)

The resolving power of differential ion mobility spectrometry (FAIMS) was dramatically increased recently by carrier gases comprising up to 75% He or various vapors, enabling many new applications. However, the need for resolution of complex mixtures is virtually open-ended and many topical analyses demand yet finer separations. Also, the resolving power gains are often at the expense of speed, in particular making high-resolution FAIMS poorly compatible with online liquid-phase separations. Here, we report FAIMS employing hydrogen, specifically in mixtures with N(2) containing up to 90% H(2). Such compositions raise the mobilities of all ions and thus the resolving power beyond that previously feasible, while avoiding the electrical breakdown inevitable in He-rich mixtures. The increases in resolving power and ensuing peak resolution are especially significant at H(2) fractions above ~50%. Higher resolution can be exchanged for acceleration of the analyses by up to ~4 times. For more mobile species such as multiply charged peptides, this exchange is presently forced by the constraints of existing FAIMS devices, but future designs optimized for H(2) should consistently improve resolution for all analytes.
Cloning and expression of β,β-carotene 15,15′-dioxygenase (2000)

Conference Abstract| October 01 2000 Cloning and expression of β,β-carotene 15,15′-dioxygenase A. Wyss; A. Wyss *Roche Ltd., Vitamins and Fine Chemicals Division, CH-4070 Basel, Switzerland e-mail: adrian.wyss@roche.com Search for other works by this author on: This Site PubMed Google Scholar G. Wirtz; G. Wirtz #Institute of Organic Chemistry, University of Basel, St. Johannsring 19, CH-4056 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar W.-D. Woggon; W.-D. Woggon #Institute of Organic Chemistry, University of Basel, St. Johannsring 19, CH-4056 Basel, Switzerland e-mail: wolf-d.woggon@unibas.ch Search for other works by this author on: This Site PubMed Google Scholar R. Brugger; R. Brugger *Roche Ltd., Vitamins and Fine Chemicals Division, CH-4070 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar M. Wyss; M. Wyss *Roche Ltd., Vitamins and Fine Chemicals Division, CH-4070 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar A. Friedlein; A. Friedlein *Roche Ltd., Vitamins and Fine Chemicals Division, CH-4070 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar H. Bachmann; H. Bachmann *Roche Ltd., Vitamins and Fine Chemicals Division, CH-4070 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar W. Hunziker W. Hunziker *Roche Ltd., Vitamins and Fine Chemicals Division, CH-4070 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A334. https://doi.org/10.1042/bst028a334a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation A. Wyss, G. Wirtz, W.-D. Woggon, R. Brugger, M. Wyss, A. Friedlein, H. Bachmann, W. Hunziker; Cloning and expression of β,β-carotene 15,15′-dioxygenase. Biochem Soc Trans 1 October 2000; 28 (5): A334. doi: https://doi.org/10.1042/bst028a334a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Solid-state polymerization of poly(aryl carbonates): a facile route to high-molecular-weight polycarbonates (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolid-state polymerization of poly(aryl carbonates): a facile route to high-molecular-weight polycarbonatesV. S. Iyer, J. C. Sehra, K. Ravindranath, and S. SivaramCite this: Macromolecules 1993, 26, 5, 1186–1187Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ma00057a046https://doi.org/10.1021/ma00057a046research-articleACS PublicationsRequest reuse permissionsArticle Views178Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts