gebhart/patrepeval huggingface dataset:
Optimizing Stem Cells Mobilization Strategies to Ameliorate Patient Outcomes: A Review of Guide- lines and Recommendations. (2017)

Peripheral blood stem cell transplantation (PBSCT) is an effective treatment for hematological malignancies. Mobilization of peripheral blood progenitor cells performs in different ways among transplantation centers. Forceful mobilization schedules are comprised of growth factor alone, chemotherapy along with growth factor and also, a newly combination of novel agent such as plerixafor with any approach. With the appearance of numerous modifications in stem cell mobilization field over the past decade and advent of novel stem cell mobilization techniques, it seems to be necessary to review recent publications about stem cell mobilization strategies to respond above cited issues. Relevant literature was identified by a PubMed search (1996–2016) of English-language literature using the terms mobilization, Allogeneic Stem Cells Transplantation, Autologous Stem Cells Transplantation and technical aspects of apheresis. Although many institutions have established their own procedures to improve stem cell mobilization success rates accompanying cost-effectiveness considerations, an optimal stem cell mobilization regimen and methods have not been well-defined, yet. Practical guidelines are required to address critical clinical issues including proper growth factor, the most Impressive chemotherapy and its dosage and appropriate time for leukapheresis initiation. Hence, based on literature, we prepared practical guidelines in this review.
Topiramato en enfermedades comórbidas: epilepsia y migraña (2006)

Introduccion. Con relativa frecuencia la epilepsia y la migrana se ven asociadas en un mismo paciente. Algunas veces es dificil distinguir unas crisis de otras. Por tanto, seria de utilidad poseer un tratamiento que fuera eficaz en ambas patologias. Se pretende estudiar la eficacia del topiramato en el tratamiento de los pacientes que padecen epilepsia y migrana. Pacientes y metodos. Se realiza un estudio observacional, longitudinal y prospectivo, donde se recoge la frecuencia de las crisis, tanto de migrana como epilepticas, en una serie de 15 pacientes con dicha comorbilidad, tratados con topiramato. Se reevaluan a los tres y seis meses de tratamiento. Resultados. Se obtienen diferencias significativas (p < 0,05) en todas las variables estudiadas (intensidad y duracion de las crisis migranosas y frecuencia de crisis migranosas y epilepticas), con una dosis mediana de topiramato de 100 mg/dia al finalizar el estudio. No se observaron efectos adversos graves. Conclusiones. El topiramato en monoterapia parece ser un tratamiento efectivo en pacientes que sufren conjuntamente crisis epilepticas y migranosas
Evolutionary transience of hypervariable minisatellites in man and the primates (1991)

Using PCR, two minisatellite loci showing extreme repeat-unit copy-number variation in humans have been characterized in great apes and monkeys. In contrast to humans, minisatellite locus MS32 is monomorphic with only 3-4 diverged repeat units in great apes, Old World and New World monkeys, this organization presumably representing the relatively stable ancestral precursor state of the human hypervariable locus. Similarly, minisatellite MS1 shows extreme repeat-copy-number variability in man compared with low copy number and minimal variability in great apes. Analysis of variant repeat units shows that the 5' and 3' regions of MS1 are relatively stable in great apes and man, and that variability in man is confined to the central region of the minisatellite. In contrast to the great apes, MS1 is highly variable in Old World monkeys. These results, as well as computer simulations of minisatellite evolution based on known mutation rates, show that short minisatellites are stable within the genome, and that the degree of polymorphism at a given locus can change dramatically over a short period of evolutionary time. The ability of hypervariable minisatellites to detect highly informative loci by cross-species hybridization is therefore largely unpredictable.
IIDT type SAW filter using acoustic reflection cancel condition with solid IDT (2003)

The performance of an IIDT (interdigitated interdigital transducer) filter using the acoustic-reflection cancel condition of the solid IDT is investigated for the substrate A1/128 degrees Y-X LiNbO/sub 3/. The acoustic reflection cancel condition is a combination of 2d/ lambda =0.5 and h/ lambda =0.026 in the solid fingers. Near this condition the solid finger width d and thickness h dependence of the acoustic reflection coefficient is calculated by the finite-element method. The solid-finger width needs to be carefully controlled during the etching process, to avoid filter response distortion caused by the acoustic reflection of the IDT and phase velocity difference between the IDT and the propagation area. A new IIDT-type SAW (surface acoustic wave) filter configuration with a reduced number of fingers is proposed. This filter has a low shape factor (the 1 dB-bandwidth to 6-dB bandwidth ratio is 1.1) and a small ripple pass band.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Intelligent Humidity Sensor for Wireless Sensor Network Agricultural Application (2011)

Wireless Sensor Networks (WSN) is now widely used in precision agriculture applications. Sensors play an important role in WSN. The traditional humidity sensors employed in the agriculture have a drawback that they acquire a large amount of data which is to be transmitted or processed. Whereas the intelligent sensor proposed in this paper uses a conventional sensor and an embedded processor that can process the data acquired using algorithms to reduce the amount of data collected, to extract only relevant information and to present this information in a format which minimizes post-processing latency. As a result of which the final processing end has to perform a little computation that too only on features (like significant changes in humidity) rather on the huge data hence reducing the power consumption. The intelligent humidity sensor reduces the amount of data processed by 50% (depending upon humidity variations) and thereby also reducing the power consumption.
Crystalline Structural Intermediates of a Breathing Metal–Organic Framework That Functions as a Luminescent Sensor and Gas Reservoir (2013)

A rod-packing, breathing MOF (1), with two crystalline structural intermediates (1 a and 1 b; H(2) btca = benzotriazole-5-carboxylic acid) has been investigated. An underlying net approach for analyzing possible breathing MOFs, and a set of geometric parameters that can quantitatively describe such a breathing structural feature, are suggested. The 3D luminescent MOF is a promising candidate for specific sensors with exceptional sorption capacity.
Clinical highlights from the National Cancer Data Base: 1996 (1996)

The National Cancer Data Base, a joint project of the American Cancer Society and the American College of Surgeons Commission on Cancer, provides a mechanism for periodic assessment of hospital-based cancer patient care. From its annual summary, health care professionals can evaluate trends in patient care to make more efficient treatment decisions. This article provides a first look at highlights from the 1996 annual summary.
Retroperitoneal Castleman's disease presenting with hydronephrosis indistinguishable from lymphoma (2011)

Castleman's disease is a rare benign lymphoproliferative disease. We describe a patient with an unusual case of retroperitoneal Castleman's disease who initially presented with hydronephrosis. Her disease manifested with a malignant appearance in positron emission tomography/computed tomography and was located in the common and internal iliac area. Retrograde double-J stent insertion failed and nephrostomy was then performed. Complete surgical removal of the disease failed because the disease was severely adherent to the ureter and adjacent iliac vessels. Antegrade double-J stent insertion also failed. The patient eventually underwent laparoscopic ureteroneocystostomy. Retroperitoneal Castleman's disease should be added to the extensive list of differential diagnoses for primary retroperitoneal tumors.
(Invited) Enabling Hetero-Integration of III-V and Ge-Based Transistors on Silicon with Ultra-Thin Buffers Formed by Interfacial Misfit Technique (2016)

In this paper, we discuss the application of the interfacial misfit (IMF) technique to enable the heterogeneous integration of III-V and Ge-based transistors on Si substrates. Ge pFETs and InAs nFETs were co-integrated on a Si substrate using common contact formation, digital etch, and gate stack formation modules. In addition, vertically stacked nanowire (NW) GaSb pFETs and InAs nFETs on Si substrates were also realized.
Synthesis of Vanadium Oxo Alkylidene Complex and Its Reactivity in Ring-Closing Olefin Metathesis Reactions (2021)

V imido alkylidenes have been applied for the ring-opening metathesis polymerization involving cyclic olefins. However, those complexes found limited application in reactions with acyclic terminal olefins due to instability toward ethylene. Experimental and theoretical studies show that the β-hydride elimination from unsubstituted metallacyclobutene is the primary decomposition pathway in those systems. Herein, we report the synthesis of the first catalytically active V oxo alkylidene, VO(CHSiMe3)(PEt3)2Cl, which exhibits the highest reported productivity with various terminal olefins in ring-closing metathesis reactions among known V catalysts. Presented DFT studies indicate that β-hydride elimination is significantly disfavored for V oxo species.
Estimation of the diaphragm neuromuscular efficiency index in mechanically ventilated critically ill patients (2018)

Repeated measurements of NMEoccl exhibit high variability, limiting the ability of a single NMEoccl maneuver to estimate neuromuscular efficiency and therefore the pressure generated by the inspiratory muscles based on EAdi.
Separation of natural antioxidants using PDMS electrophoresis microchips coupled with amperometric detection and reverse polarity (2014)

This report describes the use of PDMS ME coupled with amperometric detection for rapid separation of ascorbic, gallic , ferulic, p-coumaric acids using reverse polarity. ME devices were fabricated in PDMS by soft lithography and detection was accomplished using an integrated carbon fiber working electrode aligned in the end-channel configuration. Separation and detection parameters were investigated and the best conditions were obtained using a run buffer consisting of 5 mM phosphate buffer (pH 6.9) and a detection voltage of 1.0 V versus Ag/AgCl reference electrode. All compounds were separated within 70 s using gated injection mode with baseline resolution and separation efficiencies between 1200 and 9000 plates. Calibration curves exhibited good linearity and the LODs achieved ranged from 1.7 to 9.7 μM. The precision for migration time and peak height provided maximum values of 4% for the intrachip studies. Lastly, the analytical method was successfully applied for the analysis of ascorbic and gallic acids in commercial beverage samples. The results achieved using ME coupled with amperometric detection were in good agreement with the values provided by the supplier. Based on the data reported here, the proposed method shows suitability to be applied for the routine analysis of beverage samples.
New Delhi Metallo-β-Lactamase–producing<i>Enterobacteriaceae</i>, United States (2013)

We characterized 9 New Delhi metallo-β-lactamase-producing Enterobacteriaceae (5 Klebsiella pneumoniae, 2 Escherichia coli, 1 Enterobacter cloacae, 1 Salmonella enterica serovar Senftenberg) isolates identified in the United States and cultured from 8 patients in 5 states during April 2009-March 2011. Isolates were resistant to β-lactams, fluoroquinolones, and aminoglycosides, demonstrated MICs ≤1 µg/mL of colistin and polymyxin, and yielded positive metallo-β-lactamase screening results. Eight isolates had blaNDM-1, and 1 isolate had a novel allele (blaNDM-6). All 8 patients had recently been in India or Pakistan, where 6 received inpatient health care. Plasmids carrying blaNDM frequently carried AmpC or extended spectrum β-lactamase genes. Two K. pneumoniae isolates and a K. pneumoniae isolate from Sweden shared incompatibility group A/C plasmids with indistinguishable restriction patterns and a common blaNDM fragment; all 3 were multilocus sequence type 14. Restriction profiles of the remaining New Delhi metallo-β-lactamase plasmids, including 2 from the same patient, were diverse.
Penalized-likelihood image reconstruction for digital holography (2004)

Conventional numerical reconstruction for digital holography using a filter applied in the spatial-frequency domain to extract the primary image may yield suboptimal image quality because of the loss in high-frequency components and interference from other undesirable terms of a hologram. We propose a new numerical reconstruction approach using a statistical technique. This approach reconstructs the complex field of the object from the real-valued hologram intensity data. Because holographic image reconstruction is an ill-posed problem, our statistical technique is based on penalized-likelihood estimation. We develop a Poisson statistical model for this problem and derive an optimization transfer algorithm that monotonically decreases the cost function at each iteration. Simulation results show that our statistical technique has the potential to improve image quality in digital holography relative to conventional reconstruction techniques.
Fibronectin Binding Protein BBK32 of the Lyme Disease Spirochete Promotes Bacterial Attachment to Glycosaminoglycans (2005)

Borrelia burgdorferi, the agent of Lyme disease, causes a multisystemic illness that can affect the skin, heart, joints, and nervous system and is capable of attachment to diverse cell types. Among the host components recognized by this spirochete are fibronectin and glycosaminoglycans (GAGs). Three surface-localized GAG-binding bacterial ligands, Bgp, DbpA, and DbpB, have been previously identified, but recent studies suggested that at least one additional GAG-binding ligand is expressed on the spirochetal surface when the spirochete is adapted to the mammalian host environment. BBK32 is a surface lipoprotein that is produced during infection and that has been shown to bind to fibronectin. In this study, we show that, when BBK32 was produced from a shuttle vector in an otherwise nonadherent high-passage B. burgdorferi strain, the protein localized on the bacterial surface and conferred attachment to fibronectin and to mammalian cell monolayers. In addition, the high-passage strain producing BBK32 bound to purified preparations of the GAGs dermatan sulfate and heparin, as well as to these GAGs on the surfaces of cultured mammalian cells. Recombinant BBK32 recognized purified heparin, indicating that the bacterial attachment to GAGs was due to direct binding by BBK32. This GAG-binding activity of BBK32 is apparently independent of fibronectin recognition, because exogenous heparin had no effect on BBK32-mediated bacterial binding to fibronectin.
Is δ-Aminolevulinic Acid Dehydratase Rate Limiting in Heme Biosynthesis Following Exposure of Cells to δ-Aminolevulinic Acid?¶ (2001)

Understanding the regulation and control of heme/porphyrin biosynthesis is critical for the optimization of the delta-aminolevulinic-acid (ALA)-mediated photodynamic therapy of cancer, in which endogenously produced protoporphyrin IX (PPIX) is the photosensitizer. The human breast cancer cell line MCF-7, the rat mammary adenocarcinoma cell line R3230AC, the mouse mammary tumor cell line EMT-6 and the human mesothelioma cell line H-MESO-1 were used to study ALA-induced PPIX levels and their relationship to delta-aminolevulinic acid dehydratase (ALA-D) activity in vitro. Incubation of these cell lines with 0.5 mM ALA for 3 h resulted in a significant increase in PPIX accumulation, compared with control cells, but there was no significant change in ALA-D activity. Exposure of cells incubated with ALA to 30 mJ/cm2 of fluorescent light, a dose that would cause a 50% reduction in cell proliferation, did not significantly alter the activity of ALA-D. Increasing the activity of porphobilinogen deaminase (PBGD), the enzyme immediately subsequent to ALA-D, by four- to seven-fold via transfection of cells with PBGD complementary DNA did not alter the activity of ALA-D. However, incubation of cells with various concentrations of succinyl acetone, a potent inhibitor of ALA-D, caused a concomitant decline in both PPIX accumulation and ALA-D activity. These data imply that when cells are exposed to exogenous ALA, ALA-D is an important early-control step in heme/porphyrin biosynthesis and that regulation of PPIX synthesis by this dehydratase may impact the effectiveness of ALA-mediated photosensitization.
ConfErr: A tool for assessing resilience to human configuration errors (2008)

We present ConfErr, a tool for testing and quantifying the resilience of software systems to human-induced configuration errors. ConfErr uses human error models rooted in psychology and linguistics to generate realistic configuration mistakes; it then injects these mistakes and measures their effects, producing a resilience profile of the system under test. The resilience profile, capturing succinctly how sensitive the target software is to different classes of configuration errors, can be used for improving the software or to compare systems to each other. ConfErr is highly portable, because all mutations are performed on abstract representations of the configuration files. Using ConfErr, we found several serious flaws in the MySQL and Postgres databases, Apache web server, and BIND and djbdns name servers; we were also able to directly compare the resilience of functionally-equivalent systems, such as MySQL and Postgres.
Top 13 Blendstocks Derived from Biomass for Mixing-Controlled Compression-Ignition (Diesel) Engines: Bioblendstocks with Potential for Decreased Emissions and Improved Operability (2021)

Reducing the impacts of medium- and heavy-duty (MD/HD) ground transportation can be enabled by fuel-engine combinations that use lower compression ignition liquid fuels and reduce criteria pollutant emissions. Fuels and blendstocks combined with advanced engine technologies could reduce the cost of ownership and the emission of pollutants, including soot, nitrogen oxides (NOx) and greenhouse gases (GHGs), from MD/HD vehicles. This report describes the evaluation and screening of MD/HD mixing-controlled compression ignition (MCCI) biofuel candidates for further development and commercialization. The report is aimed at 1) biofuel researchers looking to better understand options to reduce criteria pollutant and GHG emissions while maintaining efficiency and meeting requirements for engine operability and 2) engine researchers who want to evaluate biofuels that meet diesel fuel properties for their impact on conventional and advanced diesel combustion strategies.
Molecular cloning, functional expression and localization of an inward rectifier potassium channel in the mouse brain (1993)

We have cloned an inward‐rectifier potassium channel from a mouse brain cDNA library, studied its distribution in the brain by in situ hybridization and determined the chromosomal localization of the gene. A mouse brain cDNA library was screened using a fragment of the mouse macrophage IRK1 cDNA as a probe. Two duplicate clones of ~5.5 kb were obtained. Xenopus ococytes injected with cRNA derived from the clone expressed a potassium channel with inwardly rectifying channel characteristics. The amino acid sequence of the clone was identical to that of IRK1 recently cloned from a mouse macrophage cell line. In situ hybridization study showed the mouse brain IRK1 to be generally distributed throughout the brain, but in particular subsets of neurons at high levels. The gene was placed in the distal region of mouse chromosome 11, which contains several uncloned neurological mutations. These results provide the first demonstration of the cloning and distribution of an inward rectifier potassium channel from the nervous system.
Ammoniacal Leaching and Solvent Extraction of Cobalt Crusts using Sulfur Dioxide Gas. (1998)

Cobalt crusts were leached in an ammoniacal solution using sulfur dioxide gas as a reductant, and the effects of leaching time, leaching temperature and concentration of ammonium carbonate on the leaching of nickel, cobalt, copper, iron and manganese were investigated. The selective leaching of nickel, cobalt and copper from cobalt crusts was attained by using ammonium carbonate solution and sulfur dioxide gas as a reductant. The leaching percentages of metallic elements under the suitable leaching conditions were 90 % for nickel, 97 % for cobalt, 93 % for copper, 1.8 % for iron and 6.0 % for manganese. The separation of nickel, cobalt, copper from ammonium carbonate solution was carried out by solvent extraction. Extraction experiment was done by using LIX84-I as extractant. The extraction percentages of copper and nickel were more than 99 %, while that of cobalt was less than 1.0 %. Extraction of cobalt was masked by sulfite ion. From the organic phase containing nickel and copper, nickel was selectively stripped by dilute sulfuric acid or hydrochloric acid solution at the pH of 1.5. Copper was stripped at the pH of zero.
Automatic Poisson peak harvesting for high throughput protein identification (2000)

High throughput identification of proteins by peptide mass fingerprinting requires an efficient means of picking peaks from mass spectra. Here, we report the development of a peak harvester to automatically pick monoisotopic peaks from spectra generated on matrix-assisted laser desorption/ionisation time of flight (MALDI-TOF) mass spectrometers. The peak harvester uses advanced mathematical morphology and watershed algorithms to first process spectra to stick representations. Subsequently, Poisson modelling is applied to determine which peak in an isotopically resolved group represents the monoisotopic mass of a peptide. We illustrate the features of the peak harvester with mass spectra of standard peptides, digests of gel-separated bovine serum albumin, and with Escherictia coli proteins prepared by two-dimensional polyacrylamide gel electrophoresis. In all cases, the peak harvester proved effective in its ability to pick similar monoisotopic peaks as an experienced human operator, and also proved effective in the identification of monoisotopic masses in cases where isotopic distributions of peptides were overlapping. The peak harvester can be operated in an interactive mode, or can be completely automated and linked through to peptide mass fingerprinting protein identification tools to achieve high throughput automated protein identification.