gebhart/patrepeval huggingface dataset:
Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice (2007)

Using a recently developed in vitro preparation of vagal afferent pathways, we examined the role of TRPV1 and ASIC3 on the mechano- and chemosensitive properties of gastroesophageal sensory neurons. Esophagus, stomach, and the intact vagus nerves up to the central terminations were carefully dissected from TRPV1 and ASIC3 knockout mice and wild-type controls. The organ preparation was placed in a superfusion chamber to obtain intracellular recordings from the soma of nodose neurons during luminal stimulation of esophagus and stomach. The proximal esophagus and distal stomach were separately intubated to allow perfusion and graded luminal distension. In wild-type mice, mechanosensitive neurons were activated by low distension pressures and encoded stimulus intensity over the entire range tested. Luminal acidification significantly transiently increased the resting frequency but did not alter responses to subsequent mechanical stimulation. ASIC3 and TRPV1 knockout significantly blunted responses to distension compared with wild-type controls, with deletion of TRPV1 having a more significant effect than ASIC3 deletion. Luminal acidification did not activate mechanosensory neurons in ASIC3 and TRPV1 knockout mice. Our data demonstrate a role of TRPV1 in chemo- and mechanosensation of gastroesophageal afferents. ASIC3 may contribute to acid sensation but plays a more subtle role in responses to distending stimuli. Considering the importance of acid in dyspeptic symptoms and gastroesophageal reflux, TRPV1 or ASIC3 may be an attractive target for treatment strategies in patients who do not respond to acid suppressive therapy.
Distributed adaptive channel allocation scheme with variable C/I threshold in cellular systems (2002)

The proposed scheme varies the carrier-to-interference ratio (C/I) threshold in order to reduce the probability of interference and to increase traffic handling capacity. The scheme uses a channel segregation algorithm in which, in order to avoid interference, each base station independently determines channel priority from the results of interference signal strength measurements. A higher C/I threshold is set for higher priority channels to reduce the probability of interference, and a lower C/I threshold is set for lower priority channels to decrease blocking probability. Simulation results show that for the same interference ratio, the capacity of the variable C/I threshold scheme is 20% higher than that of a constant C/I threshold scheme.
Optimal Placement of Public Electric Vehicle Charging Stations Using Deep Reinforcement Learning (2021)

The placement of charging stations in areas with developing charging infrastructure is a critical component of the future success of electric vehicles (EVs). In Albany County in New York, the expected rise in the EV population requires additional charging stations to maintain a sufficient level of efficiency across the charging infrastructure. A novel application of Reinforcement Learning (RL) is able to find optimal locations for new charging stations given the predicted charging demand and current charging locations. The most important factors that influence charging demand prediction include the conterminous traffic density, EV registrations, and proximity to certain types of public buildings. The proposed RL framework can be refined and applied to cities across the world to optimize charging station placement.
Lymphocytic Hypophysitis associated with Pregnancy (2002)

Lymphocytic hypophysitis is a rare inflammatory disease of the pituitary gland that is often recognized as a cause of hypopituitarisrn and may be due to the autoimmune pituitary destruction that usually occurs in women in the peripartum period. We report a rare case of lymphocytic hypophysitis in a 26 year-old woman presenting with nausea and headaches for 2 months after an artificial abortion of her second pregnancy. Magnetic resonance imaging, with enhancement, showed an expanding 1.01.0 cm sized sellar mass. The patient underwent transsphenoidal surgery with a preoperative diagnosis of pituitary macroadenoma. A histological examination revealed diffuse lymphocytes and plasma cells infiltration which are characteristic of lymphocytic hypophysitis. Here, we present the first reported case of a pregnant woman with lymphocytic hypophysitis with a review of the literature on this increasingly recognized condition.
Effect of 3-tesla magnetic resonance imaging on various pressure programmable shunt valves (2005)

The Sophy Polaris valve allows shunt-dependent patients who need a programmable valve to undergo 3-tesla MR imaging.
Evolutionary engagement in an ongoing collaborative work process (1996)

Article Evolutionary engagement in an ongoing collaborative work process: a case study Share on Authors: Thomas P. Moran Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CA Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CAView Profile , Patrick Chiu Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CA Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CAView Profile , Steve Harrison Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CA Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CAView Profile , Gordon Kurtenbach Alias Research, 110 Richmond, Street East, Toronto, Canada M5C 1P1 and Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CA Alias Research, 110 Richmond, Street East, Toronto, Canada M5C 1P1 and Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CAView Profile , Scott Minneman Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CA Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CAView Profile , William van Melle Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CA Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CAView Profile Authors Info & Claims CSCW '96: Proceedings of the 1996 ACM conference on Computer supported cooperative workNovember 1996 Pages 150–159https://doi.org/10.1145/240080.240243Published:16 November 1996 40citation654DownloadsMetricsTotal Citations40Total Downloads654Last 12 Months11Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Rapid appearance of plasmin in tear fluid after ocular allergen exposure. (1988)

Specific allergens were applied topically to the conjunctivae of 18 allergic patients. In cases with positive allergic reaction, proteolytic activity, identified as plasmin using zymographic analysis and a monoclonal anticatalytic antibody to plasmin, was found to appear within 3-5 min in the tear fluid, reaching concentrations of 2.2-28.6 micrograms/ml. No plasmin was detected, either in the tear fluid of 30 unchallenged non-atopic control persons, or atopic patients provoked with a test material that had given no reaction in a skin prick test. These findings suggest that generation of plasmin is a consequence of the conjunctival allergic reaction.
A method for phenomenological and chemical kinetics study of autocatalytic reactive dissolution by optical microscopy. The case of uranium dioxide dissolution in nitric acid media (2018)

Dissolution is a milestone of the head-end of hydrometallurgical processes, as the stabilization rates of the chemical elements determine the process performance and hold-up. This study aims at better understanding the chemical and physico-chemical phenomena of uranium dioxide dissolution reactions in nitric acid media in the Purex process, which separates the reusable materials and the final wastes of the spent nuclear fuels. It has been documented that the attack of sintering-manufactured uranium dioxide solids occurs through preferential attack sites, which leads to the development of cracks in the solids. Optical microscopy observations show that in some cases, the development of these cracks leads to the solid cleavage. It is shown here that the dissolution of the detached fragments is much slower than the process of the complete cleavage of the solid, and occurs with no disturbing phenomena, like gas bubbling. This fact has motivated the measurement of dissolution kinetics using optical microscopy and image processing. By further discriminating between external resistance and chemical reaction, the “true” chemical kinetics of the reaction have been measured, and the highly autocatalytic nature of the reaction confirmed. Based on these results, the constants of the chemical reactions kinetic laws have also been evaluated.
Plane wave transmission through a pair of capacitive gratings (2000)

A frequency-selective structure is investigated that represents a pair of gratings with narrow gaps in a thin conductive screen separated by a dielectric slab. In particular, the gratings may be closely spaced. The calculations show that the parasitic windows of the transparency may be shifted far from the operational frequency to the high frequency region, so that the ratio of the frequencies of the parasitic and operational windows of the transparency will exceed four. Expressions for the reflection and transmission coefficients are obtained. The results of calculations are compared with experimental data in the cases of both normal and oblique incidence.
Open source biometric recognition (2013)

The biometrics community enjoys an active research field that has produced algorithms for several modalities suitable for real-world applications. Despite these developments, there exist few open source implementations of complete algorithms that are maintained by the community or deployed outside a laboratory environment. In this paper we motivate the need for more community-driven open source software in the field of biometrics and present OpenBR as a candidate to address this deficiency. We overview the OpenBR software architecture and consider still-image frontal face recognition as a case study to illustrate its strengths and capabilities. All of our work is available at www.openbiometrics.org.
Gas source iodine doping and characterization of molecular-beam epitaxially grown CdTe (1992)

Investigations are reported on the gas source iodine doping of CdTe grown by molecular-beam epitaxy, utilizing ethyliodide as the dopant precursor. Structural and electrical characterizations of these layers showed them to have favorable crystalline properties and indicated that the electrical activity of iodine in CdTe was between 50% and 100%. Electron concentrations between 6×1016 and 3×1018 cm−3 were obtained and showed the highest mobilities measured in epitaxial n-type CdTe. These studies also showed that the incorporation of iodine was independent of the II/VI flux ratio and that its electrical activity was independent of both dopant concentration and II/VI flux ratio. The photoluminescence spectrum at 10 K was dominated by strong excitonic recombination bound to ionized and neutral iodine donors. These results demonstrate that iodine is a highly effective donor in CdTe.
Subclinical wandering spleen in a cat with gastrointestinal lymphoma (2021)

We accidentally detected a subclinical wandering spleen on preoperative ultrasonography in a cat with gastrointestinal lymphoma. If the spleen is not in the normal position, the wandering spleen should be considered.
Mechanisms of Defect Generation and Clustering in CH<sub>3</sub>S Self-Assembled Monolayers on Au(111) (2012)

Periodic density functional calculations probe that step edges play a key role as source of defects during self-assembly. It is shown that the self-assembly process strongly reduces the energy required to strip an atom from the gold surface, locally increasing the concentration of surface defects. The thermodynamic driving force for the atom stripping is considerably more favorable along step-edge lines within the self-assembly than on the higher-coordinated terrace sites. Furthermore, the clustering of surface defects is considered, and we probe that the formation of aggregates of vacancies in the form of vacancy pits significantly stabilizes the self-assembly on the terraces of gold, where the role of the step edges is expected to be less significant. The high stability of pit-like structures arises from a balance between the corrugation and the enhanced bonding of defect-rich substrates. Our results demonstrate the important role that step edges play during assembly and could be very valuable for discovering defect-free assembled structures.
Schaffer and Avery's Diseases of the Newborn (1991)

Intended for neonatologists, paediatricians, obstetricians, family physicians and nurses, this book has been revised and updated to incorporate advances in perinatology and neonatology. It offers coverage of all diseases of the newborn, the high-risk neonate, perinatal medicine, neonatal cardiology, and pharmacology. Features include guidelines for diagnosis and treatment, and case histories of specific conditions. The latest advances in genetic diseases are also discussed.
Real-Time Investigation and Prediction of Transmission Penalties for PDM-8QAM/16QAM Super-Channels in Flexible Grid DWDM Networks (2017)

Real-time transmission penalties of PDM-8QAM and PDM-16QAM super-channel system are investigated for various system configurations in a ROADM enabled flexible grid link. Gaussian noise model is verified in systems with both filtering and crosstalk penalties.
Neutron activation of holmium poly(L-lactic acid) microspheres for hepatic arterial radioembolization: a validation study (2009)

Poly(L-lactic acid) microspheres loaded with holmium-166 acetylacetonate (166Ho-PLLA-MS) are a novel microdevice for intra-arterial radio-embolization in patients with unresectable liver malignancies. The neutron activation in a nuclear reactor, in particular the gamma heating, damages the 166Ho-PLLA-MS. The degree of damage is dependent on the irradiation characteristics and irradiation time in a particular reactor facility. The aim of this study was to standardize and objectively validate the activation procedure in a particular reactor. The methods included light- and scanning electron microscopy (SEM), particle size analysis, differential scanning calorimetry, viscometry, thermal neutron flux measurements and energy deposition calculations. Seven hours-neutron irradiation results in sufficient specific activity of the 166Ho-PLLA-MS while structural integrity is preserved. Neutron flux measurements and energy deposition calculations are required in the screening of other nuclear reactors. For the evaluation of microsphere quality, light microscopy, SEM and particle size analysis are appropriate techniques.
Sol–gel horseradish peroxidase biosensor for the chemiluminescent flow determination of hydrogen peroxide (1999)

A chemiluminescent (CL) H2O2 sensor based on horseradish peroxidase (HRP) immobilized by the sol–gel method has been proposed in this paper. A new process of fabricating a non-cracking HRP encapsulated sol–gel membrane has been suggested. Flow injection analysis (FIA) was used to give reproducible results. Under optimum conditions, the sensor showed a linear response toward hydrogen peroxide in the range 0.01–2 mM with a detection limit of 8 µM. The linear relative coefficient r = 0.998. The sensor showed rapid response, good reproducibility (relative standard deviation = 2.4%) and a long lifetime of at least two months. The proposed sensor was used to determine a 30% H2O2 solution that has been stored for a long time. The results were in good agreement with the standard volumetric method.
Prospects for advances in microwave atomic frequency standards (1979)

Traditional standards based on rubidium, cesium and hydrogen have been greatly refined over the past decade, such that the frequency stability of the current generation of devices is generally limited by those basic concepts on which they are based. Future advances in frequency stability will principally come from changes in the concepts on which the standards are based, and only secondarily from more careful engineering of the old concepts. The fundamental limitations in these standards are considered and the important conceptual and component advances which could have a major impact on future performance of these standards are indicated. A very promising new class of microwave standards based on ion storage techniques is examined.
Electric Vehicles Network with Nomadic Portable Charging Stations (2010)

A novel concept of portable charging station networks to serve Electric Vehicles is described. An optimum charging station deployment method is explained, and its performance has been simulated for single highway, two intersecting highways, and Manhattan-like grid traffic models. Outage probability and service waiting delay performances are evaluated. Impact of the number PCSs and the ratio of EVs to PCSs in the service area on outage probability and waiting delay are studied. The gained insights will be used in extending this pioneer step to a stochastic framework with more realistic traffic models.
Near‐Bulk Conductivity of Gold Nanowires as Nanoscale Interconnects and the Role of Atomically Smooth Interface (2010)

Atomically smooth gold nanowires with high aspect ratios are grown using the seeded growth process. This allows control of the diameter of the nanowires to a high degree of precision. Two and four-probe nanoscale transport measurements reveal that the nanowires have low resistivity. Only a small increase in resistivity is observed between diameters of 29 nm and 185 nm suggesting that surface scattering is only a small contribution.
In vitro lysis of the bloodstream forms of Trypanosoma brucei gambiense by stearylamine-bearing liposomes (1988)

Cytolytic activity of liposomes consisting of stearylamine and phosphatidylcholine (SA/PC-liposomes) was examined in vitro against the bloodstream forms of Trypanosoma brucei gambiense. More than 99% of the cells (2 X 10(6)/ml) were killed within 30 min by treatment with 15 mol% SA/PC-liposomes (100 microM total lipids). As few as 1.2 X 10(12) liposomes per ml (equivalent to 2 nM liposome) showed trypanocidal activity. Fluorescence microscopy of cells treated with the dansylated SA/PC-liposomes suggested that the liposomes bound to and accumulated on the cell surface, eventually damaging the plasma membrane. SA/PC-liposomes showed no significant hemolysis when incubated with human and mouse erythrocytes under conditions that killed greater than 99.9% of the T. b. gambiense trypomastigotes. Human leukocytes were also shown to be less susceptible to SA/PC-liposomes than T. b. gambiense. These results may point to a new direction in strategy for therapy of African trypanosomiasis.
Analysis of the <i>DPC4</i> Gene in Gastric Carcinoma (1997)

Allelic loss on chromosome 18q is involved in the progression of gastric carcinoma. Recently, DPC4 (deleted in pancreatic carcinoma, locus 4), a candidate tumor suppressor gene, has been localized at 18q21.1. This gene is inactivated in nearly one half of pancreatic carcinomas. We tested for DPC4 gene mutations and allelic status at 18q21 in 30 primary gastric carcinomas and 5 gastric carcinoma cell lines. Polymerase chain reaction single-strand conformation polymorphism and sequencing analyses revealed no DPC4 mutations in any of the primary tumors or cell lines. Homozygous deletion of DPC4 was observed in only 1 (MKN-45) of the 5 (20%) cell lines. This suggests that the target gene for loss on 18q is not DPC4. The true tumor suppressor gene, encoded near DPC4, has yet to be identified.
Tenascin-C Expression in the Cyst Wall and Fluid of Human Brain Tumors Correlates with Angiogenesis (1997)

The presence of TN in and around the hyperplastic vessels and tumor cells present in the cyst walls of astrocytomas and its deposition in the intratumoral cyst fluid in which angiogenic factors have been detected further suggests a role for TN as an angiogenic modulator. These preliminary results suggest that immunodetection of TN in the tumor cyst fluid may indicate tumor type and grade.
Design and scale‐up of chemical reactors for nanoparticle precipitation (2006)

Abstract In recent years there has been a growing interest in production on an industrial scale of particles with size in the sub‐micron range (40‐200 nm). This can be done by controlling particle formation in order to nucleate very small particles and by tailoring the particle surface in order to avoid particle aggregation and produce stable suspensions. In this work we focus on the role of turbulent mixing on particle formation in confined impinging jet reactors. In particular, we show how computational fluid dynamics and simple precipitation models could be used to derive scale‐up criteria for the production of nanoparticles. © 2006 American Institute of Chemical Engineers AIChE J, 2006
Phase II multicenter, two-stage study of E7389 in patients with hormone refractory prostate cancer with advanced and/or metastatic disease stratified by prior chemotherapy (2007)

15513 Background: E7389 is a synthetic macrocyclic ketone derivative of the marine sponge product halichondrin B. A unique tubulin depolymerizer, E7389 induces nonproductive tubulin aggregates and inhibits tubulin polymerization. E7389 has demonstrated activity in refractory breast cancer and non small cell lung cancer with response rates of 14.7% and 9.7%, respectively. E7389 inhibits the growth of prostate cancer cell lines, including those (DU145) with over-expression of beta-tubulin III, which may confer resistance to taxanes. Methods: Phase II Simon two-stage study explores the activity and safety of E7389 as monotherapy without concomitant steroids in patients with histologically proven adenocarcinoma of the prostate that has progressed despite maintained castration. Patients are stratified into two groups that are analyzed separately, including those who failed either no prior chemotherapy (except mitoxanthrone or estramustine) or no more than one prior regimen with a tubulin binding agent, such as docetaxel. E7389 1.4 mg/m 2 is administered as a 2 to 5 minute bolus IV infusion on Days 1 and 8 of 21-day cycles. PSA measurements are obtained at the end of each cycle. The primary objective is to assess PSA response using Bubley criteria. Results: Thus far, 57 patients (37 taxane pretreated and 20 taxane naïve) have been treated. The median age is 71 (range 48–91) with 43% of patients over 75. A total of 160 treatment cycles have been given (median: 2; range: 2–7). Twelve study drug related serious adverse events have been reported in 9 patients: PE (2), melena (2), fever, neutropenia, febrile neutropenia, UTI, anemia, DVT, chest pain, and renal failure (1). Based on preliminary data, the taxane-treated group has 2 PSA responses in the first 21 patients, and the taxane-naïve group has 4 PSA responses in the first 14 patients, allowing both groups to progress to Stage 2 with further accrual. Conclusions: In patients with hormone refractory prostate cancer, there is some evidence of single agent activity for E7389 in taxane naïve and taxane pretreated patients with acceptable toxicity. Preliminary results of activity allow further recruitment to proceed. [Table: see text]