gebhart/patrepeval huggingface dataset:
An Efficient Ascending-Bid Auction for Multiple Objects (2004)

When bidders exhibit multi-unit demands, standard auction methods generally yield inefficient outcomes. This article proposes a new ascending-bid auction for homogeneous goods, such as Treasury bills or telecommunications spectrum. The auctioneer announces a price and bidders respond with quantities. Items are awarded at the current price whenever they are “clinched,” and the price is incremented until the market clears. With private values, this (dynamic) auction yields the same outcome as the (sealed-bid) Vickrey auction, but has advantages of simplicity and privacy preservation. With interdependent values, this auction may retain efficiency, whereas the Vickrey auction suffers from a generalized Winner's Curse.
Magnetic resonance elastography with a phased‐array acoustic driver system (2009)

Dynamic MR elastography (MRE) quantitatively maps the stiffness of tissues by imaging propagating shear waves in the tissue. These waves can be produced from intrinsic motion sources (e.g., due to cardiac motion), from external motion sources that produce motion directly at depth in tissue (e.g., amplitude-modulated focused ultrasound), and from external actuators that produce motion at the tissue surface that propagates into the tissue. With external actuator setups, typically only a single transducer is used to create the shear waves, which in some applications might have limitations due to shadowing and attenuation of the waves. To address these limitations, a phased-array acoustic driver system capable of applying independently controlled waveforms to each channel was developed and tested. It was found that the system produced much more uniform illumination of the object, improving the quality of the elastogram. It was also found that the accuracy of the stiffness value of any arbitrary region of interest could be improved by obtaining maximal shear wave illumination with the phased array capability of the system.
Locking the β3 Integrin I-like Domain into High and Low Affinity Conformations with Disulfides (2004)

Although integrin subunit I domains exist in multiple conformations, it is controversial whether integrin subunit I-like domains undergo structurally analogous movements of the 7-helix that are linked to affinity for ligand. Disulfide bonds were introduced into the 3 in- tegrin I-like domain to lock its 6-7 loop and 7-helix in two distinct conformations. Soluble ligand binding, ligand mimetic mAb binding and cell adhesion studies showed that disulfide-bonded receptor
Deletion of an African Swine Fever Virus ATP-Dependent RNA Helicase QP509L from the Highly Virulent Georgia 2010 Strain Does Not Affect Replication or Virulence (2022)

African swine fever virus (ASFV) produces a lethal disease (ASF) in domestic pigs, which is currently causing a pandemic deteriorating pig production across Eurasia. ASFV is a large and structurally complex virus with a large genome harboring more than 150 genes. ASFV gene <i>QP509L</i> has been shown to encode for an ATP-dependent RNA helicase, which appears to be important for efficient virus replication. Here, we report the development of a recombinant virus, ASFV-G-∆QP509L, having deleted the <i>QP509L</i> gene in the highly virulent field isolate ASFV Georgia 2010 (ASFV-G). It is shown that ASFV-G-∆QP509L replicates in primary swine macrophage cultures as efficiently as the parental virus ASFV-G. In addition, the experimental inoculation of pigs with 10<sup>2</sup> HAD<sub>50</sub> by the intramuscular route produced a slightly protracted but lethal clinical disease when compared to that of animals inoculated with virulent parental ASFV-G. Viremia titers in animals infected with ASFV-G-∆QP509L also had slightly protracted kinetics of presentation. Therefore, ASFV gene <i>QP509L</i> is not critical for the processes of virus replication in swine macrophages, nor is it clearly involved in virus replication and virulence in domestic pigs.
Towards Multiscale Topology Optimization for Additively Manufactured Components Using Implicit Slicing (2017)

Additive Manufacturing (AM) encompasses a set of fabrication technologies that are being used with increasing frequency in a wide variety of scientific and industrial pursuits. These technologies, which operate by successive additions of material to a domain, enable the manufacture of highly complex geometries that would otherwise be unrealizable. However, the material micro and meso-structures generated by AM processes differ remarkably from those that arise from conventional techniques and occasionally introduce unwanted functional features; this has been an obstacle to the use of AM in some applications. In the present work, we propose a multiscale method that utilizes the unique meso-scale structuring capabilities of implicit slicers for AM, in conjunction with existing topology optimization tools for the macro-scale, in order to generate functional components. The use of this method is demonstrated on the example of a hand tool. We discuss the applications of this methodology, its current limitations, and the future work required to enable its widespread use.
An IF FSK demodulator for Bluetooth in 0.35 μm CMOS (2002)

An FSK demodulator intended for use in Bluetooth is implemented in a 0.35 /spl mu/m CMOS process. The entire demodulator, integrated as a part of a low-IF receiver with 2 MHz intermediate frequency, consumes 3 mA from 2.7 V supply. The required signal-to-noise ratio (SNR) for 0.1% bit error rate (BER) is about 18 dB.
A simple fabrication process for polysilicon side-drive micromotors (1994)

A simple fabrication process for rapid prototyping of side-drive polysilicon micromotors has been developed. This process uses three low-pressure chemical vapor depositions and three photolithography steps, and it enables fabrication of new micromotors and flange bearing designs. An important feature of this process is that the rotor, stator, and rotor/stator gap pattern definition is the first photolithography step and is performed over a flat surface. As a result, excellent linewidth resolution is possible for defining the rotor/stator gaps. Conventional wobble and salient-pole micromotors fabricated with this process have been operated for months after release, For wobble micromotors with 3-/spl mu/m-thick rotor/stator polysilicon films, minimum operating voltages have been 25 V across 1.5-/spl mu/m rotor/stator gaps; maximum operating speeds have been 1000 rpm. limited by the power supply. Corresponding salient-pole micromotors have had minimum operating voltages of 50 V; their maximum operating speeds have been near 5000 rpm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Practical Solutions For Format-Preserving Encryption (2015)

Format Preserving Encryption (FPE) schemes encrypt a plaintext into a ciphertext while preserving its format (e.g., a valid social-security number is encrypted into a valid social-security number), thus allowing encrypted data to be stored and used in the same manner as unencrypted data. Motivated by the always-increasing use of cloud-computing and memory delegation, which require preserving both plaintext format and privacy, several FPE schemes for general formats have been previously suggested. However, current solutions are both insecure and inefficient in practice. We propose an efficient FPE scheme with optimal security. Our scheme includes an efficient method of representing general (complex) formats, and provides efficient encryption and decryption algorithms that do not require an expensive set-up. During encryption, only format-specific properties are preserved, while all message-specific properties remain hidden, thus guaranteeing data privacy. As experimental results show that in many cases large formats domains cannot be encrypted efficiently, we extend our scheme to support large formats, by imposing a user-defined bound on the maximal format size, thus obtaining a flexible security-efficiency tradeoff and the best possible security (under the size limitation).
Arrhythmogenic Right Ventricular Cardiomyopathy Causing Sudden Cardiac Death in Boxer Dogs (2004)

We describe a novel, spontaneous, and genetically transmitted animal model of ARVC associated with sudden death in the boxer dog, closely resembling the human disease. This model may aid in understanding the pathogenic mechanisms of ARVC.
Enhancing the ROS generation ability of a rhodamine-decorated iridium(<scp>iii</scp>) complex by ligand regulation for endoplasmic reticulum-targeted photodynamic therapy (2020)

The endoplasmic reticulum (ER) is a very important organelle responsible for crucial biosynthetic, sensing, and signalling functions in eukaryotic cells. In this work, we established a strategy of ligand regulation to enhance the singlet oxygen generation capacity and subcellular organelle localization ability of a rhodamine-decorated iridium(iii) complex by variation of the cyclometallating ligand. The resulting metal complex showed outstanding reactive oxygen species generation efficiency (1.6-fold higher than that of rose bengal in CH<sub>3</sub>CN) and highly specific ER localization ability, which demonstrated the promise of the metal-based photo-theranostic agent by simultaneously tuning the photochemical/physical and biological properties. Additionally, low dark cytotoxicity, high photostability and selective tumour cell uptake were featured by this complex to demonstrate it as a promising candidate in photodynamic therapy (PDT) applications. <i>In vivo</i> near infrared fluorescence (NIRF) imaging and tumour PDT were investigated and showed preferential accumulation at the tumour site and remarkable tumour growth suppression, respectively.
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice (2016)

A major obstacle to a broadly neutralizing antibody (bnAb)-based HIV vaccine is the activation of appropriate B cell precursors. Germline-targeting immunogens must be capable of priming rare bnAb precursors in the physiological setting. We tested the ability of the VRC01-class bnAb germline-targeting immunogen eOD-GT8 60mer (60-subunit self-assembling nanoparticle) to activate appropriate precursors in mice transgenic for human immunoglobulin (Ig) loci. Despite an average frequency of, at most, about one VRC01-class precursor per mouse, we found that at least 29% of singly immunized mice produced a VRC01-class memory response, suggesting that priming generally succeeded when at least one precursor was present. The results demonstrate the feasibility of using germline targeting to prime specific and exceedingly rare bnAb-precursor B cells within a humanlike repertoire.
ChemInform Abstract: Scaffold‐Based Design and Synthesis of Potent N‐Type Calcium Channel Blockers. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Rituximab-Induced Depletion of Anti-PLA2R Autoantibodies Predicts Response in Membranous Nephropathy (2011)

Autoantibodies to the M-type phospholipase A(2) receptor (PLA(2)R) are sensitive and specific for idiopathic membranous nephropathy. The anti-B cell agent rituximab is a promising therapy for this disease, but biomarkers of early response to treatment currently do not exist. Here, we investigated whether levels of anti-PLA(2)R correlate with the immunological activity of membranous nephropathy, potentially exhibiting a more rapid response to treatment than clinical parameters such as proteinuria. We measured the amount of anti-PLA(2)R using Western blot immunoassay in serial serum samples from a total of 35 patients treated with rituximab for membranous nephropathy in two distinct cohorts. Pretreatment samples from 25 of 35 (71%) patients contained anti-PLA(2)R, and these autoantibodies declined or disappeared in 17 (68%) of these patients within 12 months after rituximab. Those who demonstrated this immunologic response fared better clinically: 59% and 88% attained complete or partial remission by 12 and 24 months, respectively, compared with 0% and 33% among those with persistent anti-PLA(2)R levels. Changes in antibody levels preceded changes in proteinuria. One subject who relapsed during follow-up had a concomitant return of anti-PLA(2)R. In summary, measuring anti-PLA(2)R levels by immunoassay may be a method to follow and predict response to treatment with rituximab in membranous nephropathy.
Service-Less Video Multicast in 5G: Enablers and Challenges (2020)

The massive upsurge in production and demand of crowdsourced live streaming necessitates feasible and cost effective solutions in future cellular networks. Video multicast is one of the viable options to deliver live video using standardized multicast technologies, such as evolved Multimedia Broadcast Multicast Services (eMBMS) architecture. However, eMBMS being a service-oriented architecture, it does not support crowdsourced live video streaming from popular providers like Twitch, YouTube Live, and Facebook Live, where millions of viewers watch live streams. This article explores the possibilities for the crowdsourced service-less video multicast in fifth generation (5G) Radio Access Network (RAN). We highlight major limitations in the standard eMBMS architecture and propose a viable solution using Network Function Virtualization (NFV) and Mobile Edge Computing (MEC). The main challenges related to the initiation of an eMBMS service are presented, followed by our proposed network architecture, which augments the eMBMS architecture to initiate a service-less multicast video delivery for crowdsourced live videos. We evaluate and validate the proposed architecture using a real-world live video dataset. Our results depict the feasibility of the proposed architecture to multicast crowdsourced live streams and significant savings in cost and network consumption.
Immunization with different Pf AMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits (2011)

These findings may have implications for the current understanding of the natural acquisition of clinical immunity to malaria as well as for rational vaccine design.
Magnitude-Based Calibrated Discrete Fracture Network Methodology (2013)

Abstract Effective propped fracture half-lengths following a typical hydraulic fracture stimulation of a wellbore can be difficult to quantify. Therefore, new modeling techniques must be developed to make estimates of proppant distribution in a formation to understand the spatial extent of proppant-filled fractures. The distribution of propped and unpropped fractures can then be statistically analyzed to determine the productive stimulated rock volume (SRV) and constrain key field development parameters such as wellbore and stage spacing as well as vertical containment of proppant placement. A magnitude-based calibrated Discrete Fracture Network (DFN) methodology based on microseismicity induced during stimulation of a wellbore has been developed that incorporates magnitude of the event (and associated microseismic moment (M)), rock rigidity (μ), injected fluid volumes (Vi), and fluid efficiency (η). Calculated fracture volumes (Vf) are then scaled to account for any missing portion of the seismic population. The calibrated DFN can then be filled with the measured injected proppant volume on a stage-by-stage basis by initially filling fractures nearest the wellbore and systematically filling fractures outward from the wellbore until all deposited proppant volumes have been depleted. Fundamentally, for every microseismic hypocenter, fracture area (A) =M/μδ where δ is displacement along the slip plane. Since δ is not directly measured, it is initially estimated using an empirical relation as a function of M and corrected using a scaling factor (k) where k=Vf/[(Vi)η]. The scaling factor is calculated by comparing Vf to (Vi)η following a hydraulic fracture stimulation of an individual stage where the sum of the seismic moments is greatest (compared to all stages monitored) and energy released is only associated with fluid injection (e.g. not tectonic activity).
Model-less and model-based computationally efficient motion estimation for video compression in transportation applications (2016)

Block-based motion estimation is an important component in many video coding standards that aims at removing temporal redundancy between neighboring frames. Traditional methods for block-based motion estimation such as the Exhaustive Block Matching Algorithm (EBMA) are capable of achieving good matching performance but are computationally expensive. Alternatives to EBMA have been proposed to reduce the amount of search points by trading off matching optimality with computational resources. Although they exploit shared local spatial attributes around the target block, they fail to take advantage of the characteristics of the video sequences acquired with stationary cameras used in transportation and surveillance applications, where motion patterns are largely regularized; often, they also fail to yield semantically meaningful motion vector fields. In this paper, we propose two alternative approaches to improve the efficiency of motion estimation in video compression: (i) a highly efficient model-less approach that estimates the direction and magnitude of motion of objects in the scene and predicts the optimal search direction/neighborhood location for motion vectors; and (ii) a model-based approach that learns the dominant spatiotemporal characteristics of the motion patterns captured in the video via statistical models and enables reduced searches according to the constructed models. We demonstrate via experimental validation that the proposed methods attain computational savings, achieve improved reconstruction error and prediction capabilities for a given search neighborhood size, and yield more semantically meaningful motion vector fields when coupled with traditional motion estimation algorithms.
Nonintrusive monitoring of miscellaneous and electronic loads (2015)

A new method is proposed for monitoring miscellaneous and electronic loads (MELs) in a household. In this method, the current signal obtained at a main breaker or circuit level is disaggregated by detection of transients and classification of the waveforms. The classification is realized by probabilistic fusion of a harmonics-based classifier and a multivariate statistical technique. The results demonstrate the feasibility of the proposed method.
Surface and interface acoustic waves in SiO2/<i>Y</i> <i>X</i>-LiNbO3 (1984)

For Y-cut lithium niobate, a leaky shear horizontal (SH) surface wave is known to propagate along the X axis. When an SiO2 film is deposited on the LiNbO3 surface, the SH wave is found experimentally to have low loss and theoretical calculations show the wave to be closely confined to the surface. Two additional acoustic modes are observed in the SiO2/YX-LiNbO3 configuration. One mode is a Rayleigh-type surface wave and the other a generalized Stoneley wave. Experimental measurements and theoretical predictions of the wave velocities versus film thickness to wavelength ratio (h/λ) are presented. Measurements of the temperature coefficient of time delay are given for the SH wave showing a zero first order coefficient at h=0.42λ. The sensitivity of this wave to bending strains is also presented.
Multichannel Grating Phase-Shift Interferometers (1986)

When a beam is focused into grating elements, it is diffracted and phase-shifted. These fundamental characteristics of gratings have been found very useful for converting conventional interferometers into real-time wavefront sensors for digital computer control and data analysis. The principle of phase-shifting interferometry has been combined with above characteristics of the gratings to produce instantaneous multichannel interferograms. Attempts have been made successfully to apply these principles to three well-known interferometers, (1) the point-diffraction interferometer, (2) the radial-shear interferometer, and (3) the double-frequency crossed-grating lateral-shear interferometer. The advantages of these new approaches are simplicity and versatility, in particular, these wavefront sensors can measure wavefronts from both continuous and pulsed sources. Optical principles and the laboratory results will be shown.
Ultrashort electrical pulses open a new gateway into biological cells (2004)

Electrical models for biological cells predict that reducing the duration of applied electrical pulses to values below the charging time of the outer membrane causes a strong increase in the probability for electric field interactions with intracellular structures. For electric field amplitudes exceeding MV/m, such pulses are expected to cause electroporation of cell organelles, with the required electric field amplitude scaling linearly with the inverse of pulse duration. Experimental studies, where human cells were exposed to pulsed electric field of up to 300 kV/cm amplitude with duration as short as 10 ns, have confirmed this hypothesis. The observed effects include the breaching of intracellular granule membranes without permanent damage to the cell membrane, abrupt rises in intracellular free calcium levels, and enhanced expression of genes. At increased electric fields, the application of nanosecond pulses induces apoptosis (programmed cell death) in biological cells, an effect that has been shown to reduce the growth of tumors. The experimental studies require the use of nanosecond pulse generators with impedances in the range from 10 to 100Omega. Two typical bioelectrics pulse power sources are described
Orthogonal projections to latent structures (O‐PLS) (2002)

Abstract A generic preprocessing method for multivariate data, called orthogonal projections to latent structures (O‐PLS), is described. O‐PLS removes variation from X (descriptor variables) that is not correlated to Y (property variables, e.g. yield, cost or toxicity). In mathematical terms this is equivalent to removing systematic variation in X that is orthogonal to Y . In an earlier paper, Wold et al. ( Chemometrics Intell. Lab. Syst . 1998; 44 : 175–185) described orthogonal signal correction (OSC). In this paper a method with the same objective but with different means is described. The proposed O‐PLS method analyzes the variation explained in each PLS component. The non‐correlated systematic variation in X is removed, making interpretation of the resulting PLS model easier and with the additional benefit that the non‐correlated variation itself can be analyzed further. As an example, near‐infrared (NIR) reflectance spectra of wood chips were analyzed. Applying O‐PLS resulted in reduced model complexity with preserved prediction ability, effective removal of non‐correlated variation in X and, not least, improved interpretational ability of both correlated and non‐correlated variation in the NIR spectra. Copyright © 2002 John Wiley & Sons, Ltd.
Preparation and properties of unsintered MgB[sub 2] superconducting tapes (2002)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation G. Grasso, V. Braccini, A. Malagoli, N. Scati, S. Roncallo, A. S. Siri; Preparation and properties of unsintered MgB2 superconducting tapes. AIP Conf. Proc. 15 May 2002; 614 (1): 856–863. https://doi.org/10.1063/1.1472625 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search