gebhart/patrepeval huggingface dataset:
Induction of RhoGAP and Pathological Changes Characteristic of Alzheimers Disease by UAHFEMF Discharge in Rat Brain (2005)

Novel experiments with Ultrasound Associated with High Frequency Electromagnetic Field (UAHFEMF) irradiation on rats and mice found evidences of characteristic Alzheimer's disease (AD) degenerations including neurite plaques, beta-amyloid, TAU plaque and deposition in cells, Neuro-Fibrillary Tangle and Paired Helical Filament (PHF) with rats and mice irradiated up to 2454 hours. Concomitant passive avoidance test was performed on six mice, and all showed signs of visual and auditory agnosia and lost cognition of threatening condition. The post section Thioflavin-S fluorescent microscopy found dilated ventricles and dense amyloid-deposition in Ca3 and dentate gyrus. In addition, PHF was identified in the 2454 hours-irradiated rat brain by electron microscope. A human T-cell activation RhoGTPase-activating protein (TAGAP) isoform b homolog (GenBank accession # P84107) induced in the UAHFEMF-treated rat brain was identified using electron spray ionization (ESI) liquid chromatography tandem mass spectrometry (LC/MS/MS). We hypothesized that one of the causes of AD can be the UAHFEMF discharges in human brain.
Primary abdominal hydatid cyst presenting in emergency as appendicular mass: a case report (2009)

Hydatid disease, caused by Echinococcus granulosus, is a common parasitic infection of the liver. Disseminated intra-abdominal hydatid disease may occur following rupture of the hydatid cyst into the peritoneal cavity, producing secondary echinococcosis. Rarely cyst may develop de-novo in the peritoneal cavity without involvement of any other intra-abdominal organs. We present a unique case of 56-year-old woman with a primary intraabdominal hydatid cyst in the right iliac fossa masquerading as appendicular lump.
Use of Flt3 Ligand to Evaluate Residual Hematopoiesis after Heterogeneous Irradiation in Mice (2006)

We evaluated the possibility of using plasma Flt3 ligand (FL) concentration as a biological indicator of bone marrow function after heterogeneous irradiation. Mice were irradiated with 4, 7.5 or 11 Gy with 25, 50, 75 or 100% of the bone marrow in the field of irradiation. This model of irradiation resulted in graded and controlled damage to the bone marrow. Mice exhibited a pancytopenia correlated with both the radiation dose and the percentage of bone marrow irradiated. The FL concentration in the blood increased with the severity of bone marrow aplasia. Nonlinear regression analysis showed that the FL concentration was strongly correlated with the total number of residual colony-forming cells 3 days after irradiation, allowing a precise estimate of residual hematopoiesis. Moreover, the FL concentration on day 3 postirradiation was correlated with the duration and severity of subsequent pancytopenia, suggesting that variations in FL concentrations might be used as a predictive indicator of bone marrow aplasia, especially by the use of linear regression equations describing these correlations. Our results provide a rationale for the use of FL concentration as a biological indicator of residual hematopoiesis after heterogeneous irradiation.
Towards a Frequency Distribution of Effective Permeabilities of Leaky Wellbores (2013)

The risk of leakage along existing wellbores associated with CO2 sequestration depends strongly upon the leakage path permeabilities. If enough buildups of surface casing pressure (SCP) and rates of surface casing vent flow (SCVF) recorded on intermediate wellbore casing strings are available, a frequency distribution of leakage path permeability values can be obtained. Uncertainty about the location of the leak source results in a range of leakage path permeability values for each measurement of SCP or SCVF. Most permeability values exceed intact cement permeability, consistent with the presence of cracks or other defects in the formation/cement/casing interface. Assuming the gas migration path through leaky wellbores in hydrocarbon reservoirs is analogous to the leakage path for CO2 plumes, the distribution of inferred permeabilities enables quantitative estimation of CO2 leakage fluxes.
Measuring Spherical Harmonic Coefficients on a Sphere (2003)

The eigenfunctions of Rayleigh-Taylor modes on a spherical capsule are the spherical harmonics Y{sub l,m} These can be measured by measuring the surface perturbations along great circles and fitting them to the first few modes by a procedure described in this article. For higher mode numbers, it is more convenient to average the Fourier power spectra along the great circles, and then transform them to spherical harmonic modes by an algorithm derived here.
An Effective Synthesis of N,N-Diphenyl Carbazolium Salts (2017)

Tetraaryl ammonium salts are a synthetic challenge, since there is no general method for the arylation of triaryl amines. Contrary to other quaternary ammonium salts, tetraaryl ammonium salts should be very chemically stable. The ipso carbons are not very electrophilic, since the positive charge is distributed throughout the pi systems and they have no acidic β hydrogens. Here we demonstrate a simple approach to N,N-diphenyl carbazolium salts using only three synthetic steps, allowing for an easy production of these salts in large amounts and in a relatively short time. In addition, we study the Cu(I) catalyzed multi-arylation of 2,2’-diaminobiphenyl, focusing on the regioselectivity of each step. Finally, we characterize, for the first time, the solid state structure of a tetraaryl ammonium salt.
SVC-based multisource streaming for robust video transmission in mobile ad hoc networks (2006)

Emerging noninfrastructure-based network types like mobile ad-hoc networks (MANETs) are becoming suitable platforms for exchanging/sharing real-time video streams, because of recent progress in routing algorithms, throughput and transmission bit-rate. MANETs are characterized by highly dynamic behavior of the transmission routes and path outage probabilities. In this article a multisource streaming approach is presented to increase the robustness of real-time video transmission in MANETs. For that, video coding as well as channel coding techniques on the application layer are introduced, exploiting the multisource representation of the transferred media. Source coding is based on the scalable video coding (SVC) extension of H.264/MPEG4-AVC with different layers for assigning importance for transmission. Channel coding is based on a novel unequal packet loss protection (UPLP) scheme, which is based on Raptor forward error correction (FEC) codes. While in the presented approach, the reception of a single stream guarantees base quality only, the combined reception enables playback of video at full quality and/or lower error rates. Furthermore, an application layer protocol is introduced for supporting peer-to-peer based multisource streaming in MANETs.
Reproductive Health in the American Workplace (1995)

Helping workers understand their risk of reproductive and developmental hazard exposure can be demanding for the occupational health nurse. The lack of conclusive information about most suspected hazards, as well as concern over job security and advancement, make this issue doubly challenging. Further research is needed to verify or rule out the suspected toxic effects of a hazard. The occupational health nurse must make every effort to keep abreast of new research findings and federal or state requirements related to reproductive hazards. The key to promoting the reproductive health of American workers is primary prevention (Bernhardt, 1990). Educating and counseling workers about reproductive hazards so that they can make informed decisions about their reproductive health, along with implementing engineering controls or ergonomic changes to reduce the risk of exposure, should be the goal of all occupational health programs.
Mechanism of allicin inhibiting tumor growth (2010)

OBJECTIVE:To investigate the effect of allicin on tumor vascular endothelial growth factor (VEGF) and its upstream regulator HIF-1α gene expression,to explore its mechanism of inhibiting tumor growth.METHODS:The tumor-bearing mice were injected subcutaneously with different doses of allicin,to monitor the tumor growth;the ELISA assay was used to detect the expression of VEGF in serum;realtime-PCR was used to detect the expression of VEGF,HIF-1α mRNA in tumor tissue;Immunohistochemistry was used to detect the expression of CD34 and to quantify the number of microvessels in tumor;Western blot was used to detect HIF-1α protein expression.RESULTS:Different doses of allicin could inhibit the tumor growth in mice and demonstrate the property of dose-dependent.Compared with the control group,the weight of low and high-dose groups were 71.4% and 40.8% respectively;the expression of VEGF mRNA were decreased obviously and were 64.5% and 62.9% reseparately in serum and 34.6%,32.3% respectively in tumor tissue.At the same time the expression of HIF-1α also reduced and were 26.7% and 25.1% compared with the controls.The expression of the CD34 were significantly reduced in tumor and were 16.8% and 14.4% respectively (P0.01).CONCLUSIONS:Allicin can inhibit tumorgrowth through inhibiting the VEGF expression and then inhibiting tumor angiopoiesis.This inhibitory effect may be through blocking the expression of,upstream regulation gene of VEGF,HIF-1α firstly to achieve.This research provides a theoretical basis for tumor clinical pharmacology studies.
S$A: A Shared Cache Attack That Works across Cores and Defies VM Sandboxing -- and Its Application to AES (2015)

The cloud computing infrastructure relies on virtualized servers that provide isolation across guest OS's through sand boxing. This isolation was demonstrated to be imperfect in past work which exploited hardware level information leakages to gain access to sensitive information across co-located virtual machines (VMs). In response virtualization companies and cloud services providers have disabled features such as deduplication to prevent such attacks. In this work, we introduce a fine-grain cross-core cache attack that exploits access time variations on the last level cache. The attack exploits huge pages to work across VM boundaries without requiring deduplication. No configuration changes on the victim OS are needed, making the attack quite viable. Furthermore, only machine co-location is required, while the target and victim OS can still reside on different cores of the machine. Our new attack is a variation of the prime and probe cache attack whose applicability at the time is limited to L1 cache. In contrast, our attack works in the spirit of the flush and reload attack targeting the shared L3 cache instead. Indeed, by adjusting the huge page size our attack can be customized to work virtually at any cache level/size. We demonstrate the viability of the attack by targeting an Open SSL1.0.1f implementation of AES. The attack recovers AES keys in the cross-VM setting on Xen 4.1 with deduplication disabled, being only slightly less efficient than the flush and reload attack. Given that huge pages are a standard feature enabled in the memory management unit of OS's and that besides co-location no additional assumptions are needed, the attack we present poses a significant risk to existing cloud servers.
Phase 2a, randomized, double‐blind, placebo‐controlled, multicenter, parallel‐group study of a H<sub>4</sub>R‐antagonist (<scp>JNJ</scp>‐39758979) in<scp>J</scp>apanese adults with moderate atopic dermatitis (2014)

This trial was conducted to evaluate the safety and efficacy of the H4 R-antagonist JNJ-39758979 in adult Japanese patients with moderate atopic dermatitis (AD). Eligible patients were randomly assigned to JNJ-39758979 300 mg, 100 mg or placebo once daily for 6 weeks in this phase 2a, double-blind, multicenter, placebo-controlled study. Primary efficacy was assessed via week-6 Eczema Area and Severity Index (EASI) scores. Secondary efficacy assessments included Investigator's Global Assessment (IGA) and patient-reported outcome (PRO) pruritus assessments (Pruritus Categorical Response Scale [PCRS], Pruritus Numeric Rating Scales [PNRS], Pruritus Interference Numeric Rating Scale [PINRS] and Subject's Global Impressions of Change in Pruritus [SGICP]). Eighty-eight of 105 planned patients were randomized before the study was stopped and unblinded for safety reasons. The study did not meet the primary end-point. However, numerical improvements (i.e. decreases) in median EASI were observed with JNJ-39758979 100 mg (-3.7) and 300 mg (-3.0) versus placebo (-1.3) at week 6. Nominally significant improvements across PRO PCRS, PNRS and SGICP assessments were consistently observed, particularly with JNJ-39758979 300 mg. Safety, including adverse events (AE), was comparable between JNJ-39758979 and placebo with the exception of two patients (both receiving JNJ-39758979 300 mg) with serious AE of neutropenia, leading to premature study discontinuation. No deaths were reported. Except for neutropenia, no clinically relevant changes in laboratory values were observed. Although not conclusive, findings suggest H4 R-antagonism may be beneficial for AD, particularly in controlling pruritus. JNJ-39758979 appears to be associated with drug-induced agranulocytosis, likely an off-target effect.
Subtypes of losartan‐sensitive angiotensin receptor in the rabbit pulmonary artery (1996)

1. The short rabbit pulmonary artery was denuded of endothelium and divided into three sections, the cardiac end (cardiac), middle and pulmonary end (pulmonary) sections, respectively. Des-Asp-angiotensin I attenuated the contractions of the cardiac and middle sections to transmural nerve stimulation but potentiated the contractions in the pulmonary section. 2. The actions of the nonapeptide were inhibited completely by 10(-6) M losartan; however, a similar concentration of PD123319 had no effect. Indomethacin (10(-6) M) also inhibited completely the attenuation in the cardiac and middle sections but had no effect on the potentiation seen in the pulmonary section. 3. The data suggest that the two differential responses of the pulmonary artery to des-Asp-angiotensin I are mediated by two separate subtypes of the losartan-sensitive angiotensin AT1 receptor.
Antifungal properties of 2-bromo-3-fluorosuccinic acid esters and related compounds (1977)

Twelve esters (C1-C6) of erythro- and threo-2-bromo-3-fluorosuccinic acid and related compounds were tested for antifungal activity against Candida albicans, Aspergillus niger, Mucor mucedo, and Trichophyton mentagrophytes at pH 5.7 and 7.0 in the absence and presence of 10% beef serum in Sabouraud dextrose agar. At pH 7.0 in the presence of 10% beef serum, no consistent pattern in the fungitoxicity of the erythro- and threo-2-bromo-3-fluorosuccinate esters was seen. Increasing the length of the ester function affects fungitoxicity as follows: C2 greater than C1 greater than C3 greater than C4 greater than C5 greater than C6. The most fungitoxic compound in this study was threo-ethyl 2-bromo-3-fluorosuccinate (C. albicans, 14 mug/ml; A. niger, 30 mug/ml; M. mucedo, 9 mug/ml; T. mentagrophytes, 5 mug/ml). Due to the ease of dehydrohalogenation, the fungitoxicity of 2-bromo-3-fluorosuccinic acid esters may be the result of a mixture composed of the parent compound, the bromo- and fluorofumaric acid esters, and HF and HBr of which part may be formed extracellularly and part within the cell.
L-SYSTEM DESCRIPTION OF SUBDIVISION CURVES (2003)

In recent years, subdivision has emerged as a major geometric modeling technique. Algorithms for generating subdivision curves are often specified in terms of iterated matrix multiplication. Each multiplication maps a globally indexed sequence of points that represents a coarser approximation of the curve onto a longer sequence that represents a finer approximation. Unfortunately, this use of matrices and indices obscure the local and stationary character of typical subdivision rules.We introduce parametric context-sensitive L-systems with affine geometry interpretation as an alternative technique for specifying and generating subdivision curves. This technique is illustrated using Chaikin, cubic B-spline, and Dyn-Levin-Gregory (4-point) subdivision schemes as examples. L-systems formalize subdivision algorithms in an intuitive, concise, index-free manner, reflecting the parallel and local character of these algorithms. Furthermore, L-system specification of subdivision algorithms directly leads to their computer implementation.
IAA and N6-Benzyladenine InhibitEthylene-Regulated Expression of ACC Oxidase and ACC Synthase Genes inMungbean Hypocotyls (2001)

Regulation of expression of 1-aminocyclopropane-1-carboxylate (ACC) oxidase (VR-ACO1) and ACC synthase (VR-ACS1) genes by ethylene, indole-3-acetic acid (IAA), and N(6)-benzyladenine (BA), was investigated in mungbean hypocotyl tissues. Exogenous ethylene markedly increased transcript level of VR-ACO1 and reduced that of VR-ACS1, whereas aminooxyacetic acid (AOA), an inhibitor of ethylene biosynthesis, decreased the level of VR-ACO1 mRNA and increased that of VR-ACS1, indicating that expression of VR-ACO1 and VR-ACS1 genes are under positive and negative feedback control by ethylene, respectively. However, IAA treatment reduced the level of VR-ACO1 transcripts and increased that of VR-ACS1, although the hormone greatly induced ethylene production. We have demonstrated that, in a system that separates the effect of IAA proper from the effect of IAA-induced ethylene, the amount of IAA-induced ethylene was enough to cause accumulation of VR-ACO1 mRNA and decrease of VR-ACS1 mRNA. We have also shown that the responsiveness of VR-ACO1 and VR-ACS1 to exogenous ethylene was greatly reduced in the presence of IAA. In addition, BA abolished ethylene responsiveness with respect to expression of VR-ACO1 and VR-ACS1. Based on these results, we suggest that IAA and BA inhibit ethylene action, resulting in suppression of VR-ACO1 expression and induction of VR-ACS1 expression.
Scattering properties of discontinuities in NRD guide (1994)

The scattering characteristics of a guided wave by a class of discontinuities in a nonradiative dielectric (NRD) guide are systematically investigated by a method which combines the building block approach of multimode network theory with a rigorous mode-matching procedure. Some experimental data justify the effectiveness and accuracy of the present method. Extensive numerical results are obtained to develop useful guidelines for the design of NRD guide components.
Induction of cytotoxicity in human lung adenocarcinoma cells by 6‐<i>O</i>‐carboxypropyl‐α‐tocotrienol, a redox‐silent derivative of α‐tocotrienol (2005)

Tocotrienols are one of the most potent anticancer agents of all natural compounds and the anticancer property may be related to the inactivation of Ras family molecules. The anticancer potential of tocotrienols, however, is weakened due to its short elimination half life in vivo. To overcome the disadvantage and reinforce the anticancer activity in tocotrienols, we synthesized a redox-silent analogue of alpha-tocotrienol (T3), 6-O-carboxypropyl-alpha-tocotrienol (T3E). We estimated the possibility of T3E as a new anticancer agent against lung adenocarcinoma showing poor prognosis based on the mutation of ras gene. T3E showed cytotoxicity against A549 cells, a human lung adenocarcinoma cell line with a ras gene mutation, in a dose-dependent manner (0-40 microM), whereas T3 and a redox-silent analogue of alpha-tocopherol (T), 6-O-carboxypropyl-alpha-tocopherol (TE), showed much less cytotoxicity in cells within 40 microM. T3E cytotoxicity was based on the accumulation of cells in the G1-phase of the cell-cycle and the subsequent induction of apoptosis. Similar to this event, 24-hr treatment of A549 cells with 40 microM T3E caused the inhibition of Ras farnesylation, and a marked decrease in the levels of cyclin D required for G1/S progression in the cell-cycle and Bcl-xL, a key anti-apoptotic molecule. Moreover, the T3E-dependent inhibition of RhoA geranyl-geranylation is an inducing factor for the occurrence of apoptosis in A549 cells. Our results suggest that T3E suppresses Ras and RhoA prenylation, leading to negative growth control against A549 cells. In conclusion, a redox-silent analogue of T3, T3E may be a new candidate as an anticancer agent against lung adenocarcinoma showing poor prognosis based on the mutation of ras genes.
Compatible Digital Rights Management System on MS Windows Platform (2009)

Digital rights management systems (DRMS) tend to solve two aspects about rights protection of the protected content for content provider: access control and usage control. Access control concerns about how users access the content, while usage control focuses on how users use it. In this paper, we introduce some key techniques and strategies to overcome the difficulties in implementation of a compatible and transparent-to-user DRMS on Windows NT platforms. These techniques, including hardware fingerprint encryption (HFE), Win32 API Hook and kernel function interception, have been carried out and applied in experiments based on Adobe Reader (PDF file) and the results shows that they have the potential to solve both of the problems mentioned above.
Possibilities and limitations in miniaturized sensor design for uric acid (1998)

Uric acid (UA) has been under intensive investigation by electrochemists owing to its important role as a metabolite in biological fluids. One of the major problems in biological determinations of uric acid comes from electrochemical interferences such as ascorbic acid (AA), which has a similar oxidation potential, E1/2 approximately 200 mV versus SCE, at graphite electrodes, and is present at high concentrations in biological systems. UA undergoes a 2 H+, 2 e- oxidation in aqueous buffers. The oxidation product, a diimine, is an unstable intermediate with a half-life of less than 22 ms. A follow-up hydration reaction converts the diimine to an imine alcohol. Results of previous work show that UA weakly adsorbs and undergoes a fast electron transfer reaction, ks = 54 s-1, at carbon fiber electrodes. These characteristics make UA an excellent candidate for fast scan voltammetric (FSV) determinations. This paper presents the results of FSV at bare carbon fiber electrodes. The results show good selectivity and sensitivity in the determination of low concentrations of UA in the presence of high concentrations of AA. By increasing the scan rate above 500 V s-1, voltammograms of UA in the presence of AA can be resolved because of the kinetic differences in the response of the two anions, without the need for a permselective film on the electrode. Results are also presented that demonstrate an effective way to reach a stable background current at bare carbon fiber electrodes, which is required in FSV because the signal from the analyte is smaller than the electrochemical signal from the background current. Signal-to-noise ratios at bare carbon fiber electrodes in FSV are improved, because the high temporal resolution in fast scan methods allows the acquisition of a large number of scans that can be signal averaged in a short period of time. In addition, large signals can be measured because the voltammetric peak current increases with increase in scan rate.
Inherent Complexities of Trace Detection by Surface‐Enhanced Raman Scattering (2005)

Surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS) are powerful optical scattering techniques used in such frontier areas of research as ultrasensitive chemical analysis, the characterization of nanostructures, and the detection of single molecules. However, measuring and, most importantly, interpreting SERS/SERRS spectra can be incredibly challenging. This is the result of modifications to the measured spectra that are due to of a variety of instabilities and contributions. These interferences and modifications arise from the nature of the enhancement itself, as well as the conditions used to attain SERS spectra. The present report is an attempt to collect in one place the analytical interferences that are most commonly found during the collection of SERS/SERRS spectra.