gebhart/patrepeval huggingface dataset:
Energy dissipation in microfluidic beam resonators (2010)

The fluid–structure interaction of resonating microcantilevers immersed in fluid has been widely studied and is a cornerstone in nanomechanical sensor development. In many applications, fluid damping imposes severe limitations by strongly degrading the signal-to-noise ratio of measurements. Recently, Burg et al . ( Nature , vol. 446, 2007, pp. 1066–1069) proposed an alternative type of microcantilever device whereby a microfluidic channel was embedded inside the cantilever with vacuum outside. Remarkably, it was observed that energy dissipation in these systems was almost identical when air or liquid was passed through the channel and was 4 orders of magnitude lower than that in conventional microcantilever systems. Here, we study the fluid dynamics of these devices and present a rigorous theoretical model corroborated by experimental measurements to explain these observations. In so doing, we elucidate the dominant physical mechanisms giving rise to the unique features of these devices. Significantly, it is found that energy dissipation is not a monotonic function of fluid viscosity, but exhibits oscillatory behaviour, as fluid viscosity is increased/decreased. In the regime of low viscosity, inertia dominates the fluid motion inside the cantilever, resulting in thin viscous boundary layers – this leads to an increase in energy dissipation with increasing viscosity. In the high-viscosity regime, the boundary layers on all surfaces merge, leading to a decrease in dissipation with increasing viscosity. Effects of fluid compressibility also become significant in this latter regime and lead to rich flow behaviour. A direct consequence of these findings is that miniaturization does not necessarily result in degradation in the quality factor, which may indeed be enhanced. This highly desirable feature is unprecedented in current nanomechanical devices and permits direct miniaturization to enhance sensitivity to environmental changes, such as mass variations, in liquid.
Analysis of boron strain compensation in silicon-germanium alloys by Raman spectroscopy (2006)

The impact of heavy boron doping on the biaxial compressive strain in Si1−xGex layers grown on Si has been investigated using Raman spectroscopy and theoretical calculations. It is shown that one boron atom is sufficient to compensate the strain due to approximately 6.9 Ge atoms. This effect is appreciably large for boron concentrations as low as 1%, typical for applications, which employ heavily boron doped layers. Using strain compensation, the Ge content can be substantially increased without increasing the stored strain energy. This phenomenon can be useful in applications, which require low-resistivity p-type strained Si1−xGex layers with high Ge content.
Transport of cholesterol (1983)

.ur current model for cholesterol transport is summarized in Figure 10. In this figure we have put together the various steps in cholesterol transport that were described previously in this review. Under normal conditions, cholesterol metabolism and transport are well regulated. If the transport system is overloaded for a long time, however, hypercholesterolemia caused mainly by increased plasma LDL may develop in several species, including humans. Under such circumstances reverse transport of cholesterol may also fail, giving rise to deposits of cholesterol. Tissue macrophages may be responsible for this lipid accumulation, because receptor-mediated (adsorptive) endocytosis of lipoprotein-associated cholesterol in these cells is not under negative-feedback control. The deposits are mainly found in tissues poorly supplied with blood and lymph: the skin, tendons, the cornea, and arteries. Overload of cholesterol transport may be the result of too much fat and cholesterol in the diet, giving rise to cholesterol-rich lipoproteins from the gut and to increased production of liver (formula; see text) VLDL, which in humans ends up as LDL. In many individuals, however, no hypercholesterolemia is seen, even after eating large amounts of a "western" diet for decades; others may develop increased LDL on a relatively "prudent" diet. Obviously many of the factors and mechanisms in cholesterol transport are influenced by genetic factors. Although studies of several inborn errors of lipid metabolism have given information about some mechanisms, the quantitatively more important differences in genetic patterns, which determine whether or not a western diet will result in hyperlipidemia, are not well known. Perhaps studies of different forms of apoB and apoE and of HDL subgroups and hyper-alpha-lipoproteinemia will explain why certain individuals develop hypercholesterolemia and premature atherosclerosis. All the recent information related to cholesterol metabolism and transport gives rise to new questions. There are many problems of interest for future research: What are the metabolic differences between the apoB produced in the liver and that produced in the gut? To what extent is the protein moiety of LDL modified in the plasma of blood and lymph and in interstitial tissue? Are such modifications important to whether LDL uptake goes through the classic LDL pathway or through the macrophage (i.e., scavenger?) pathway? Are some changes in apoB important for liver recognition of LDL?(ABSTRACT TRUNCATED AT 400 WORDS)
B-cell maturation antigen expression across hematologic cancers: a systematic literature review (2020)

B-cell maturation antigen (BCMA) plays a critical role in regulating B-cell proliferation and survival. There is evidence for BCMA expression in various hematologic malignancies, suggesting that BCMA may play an important role as a biomarker or therapeutic target in these diseases. Given advances in understanding the role of BCMA in B-cell development and the promise of BCMA as a therapeutic target, a systematic review is needed to rigorously assess the evidence for BCMA expression and identify areas of consensus and future research. The objective of this review was to summarize the evidence on BCMA protein and mRNA expression across hematologic malignancies. Using a PubMed database search up to 28 August 2019, a systematic literature review of publications reporting BCMA expression in patients with hematologic malignancies was conducted. Data from published congress abstracts presented at the American Society of Clinical Oncology and the American Society of Hematology were also searched. Studies that assessed BCMA expression (protein or mRNA) in patients of any age with hematologic malignancies were included. A total of 21 studies met inclusion criteria and were included in the review. BCMA was expressed in several hematologic malignancies, including multiple myeloma (MM), chronic lymphocytic leukemia, acute B-lymphoblastic leukemia, non-Hodgkin lymphoma (NHL), and Hodgkin lymphoma. BCMA was expressed at uniformly high levels across all 13 MM studies and at low to moderate levels in acute myeloid leukemia and acute lymphoblastic leukemia. These results suggest that BCMA is a relevant target in MM as well as in a subset of B-cell leukemia. BCMA expression in Hodgkin lymphoma and NHL varied across studies, and further research is needed to determine the utility of BCMA as an antibody target and biomarker in these diseases. Differences in sample type, timing of sample collection, and laboratory technique used may have affected the reporting of BCMA levels.
Dual-Metal-Gate InAs Tunnel FET With Enhanced Turn-On Steepness and High On-Current (2014)

A novel approach to optimize tunnel field-effect transistors (TFETs) by technology computer-aided design simulations is reported. The most interesting outcome of our design effort is a dual-metal-gate (DMG) TFET, which features an inverse subthreshold slope (SS) significantly over more than five orders of magnitude of drain current, with a minimum value of 6 mV/decade sustained across one drain-current decade or more. The DMG-TFET simultaneously fulfills both the low-standby-power off-state current and the high-performance on-state current at a supply voltage of 0.5 V. Therefore, 25% reduction of static power consumption is expected compared with the 2020 International Technology Roadmap for Semiconductors requirements for multigate transistors.
Color-Tunable Highly Polarized Emissions from Uniaxially Aligned Thin Films of Thiophene/Phenylene Co-oligomers (2000)

Epitaxial growth of thiophene/phenylene co-oligomers(e.g., see Figure) on uniaxially oriented poly(p-phenylene) (PPP) is reported. The emission properties of these co-oligomer thin films are investigated and compared to those of films grown on quartz. Color-tunable emission highly polarized along the direction of orientation of the PPP is observed in the former case, while isotropic emission occurs on the quartz substrate.
Simulation of cooperating robot manipulators on a mobile platform (1991)

The dynamic equations of motion are presented for two or more cooperating manipulators on a freely moving mobile platform. The system of cooperating robot manipulators forms a closed kinematic chain where the force of interaction must be included in the formulation of robot and platform dynamics. The formulation includes the full dynamic interactions from arms to platform and arm tip to arm tip, and the possible translation and rotation of the platform. The equations of motion are shown to be identical in structure to the fixed-platform cooperative manipulator dynamics. The structure of the closed-chain dynamics, allows the use of any solution for the open topological tree of base and manipulator links. The number of degrees of freedom (DOF) of the system is sufficiently large to make recursive dynamic calculation methods potentially more efficient than closed-form solutions. A complete simulation with two 6-DOF manipulators of a free-floating platform is presented along a with a multiple-arm controller to position the common load.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy (2020)

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways. Physical segregation of proteins in lipid rafts may modulate the accessibility of proteins to regulatory or effector molecules. Thus, lipid rafts serve as sorting platforms and hubs for signal transduction proteins. Cancer cells contain higher levels of intracellular cholesterol and lipid rafts than their normal non-tumorigenic counterparts. Many signal transduction processes involved in cancer development (insulin-like growth factor system and phosphatidylinositol 3-kinase-AKT) and metastasis [cluster of differentiation (CD)44] are dependent on or modulated by lipid rafts. Additional proteins playing an important role in several malignant cancers (e.g., transmembrane glycoprotein mucin 1) are also being detected in association with lipid rafts, suggesting a major role of lipid rafts in tumor progression. Conversely, lipid rafts also serve as scaffolds for the recruitment and clustering of Fas/CD95 death receptors and downstream signaling molecules leading to cell death-promoting raft platforms. The partition of death receptors and downstream signaling molecules in aggregated lipid rafts has led to the formation of the so-called cluster of apoptotic signaling molecule-enriched rafts, or CASMER, which leads to apoptosis amplification and can be pharmacologically modulated. These death-promoting rafts can be viewed as a linchpin from which apoptotic signals are launched. In this review, we discuss the involvement of lipid rafts in major signaling processes in cancer cells, including cell survival, cell death, and metastasis, and we consider the potential of lipid raft modulation as a promising target in cancer therapy.
Enhancing End-to-End QoS for Multimedia Streaming in IMS-Based Networks (2007)

Convergence of the emerging IP Multimedia Subsystem (IMS) includes unlicensed, nondedicated and nondetemzinistic, hence uncontrollable computer access networks for IP multimedia services. It enables provision of resource demanding real-time sewices and multimedia communication raising new end-to-end Quality-of-Sewice (QoS) challenges, for which quality adaptation using resource management is proposed as a solution in this paper: This is an integrated solution taking both IMS and computer access networks into account as well as the two end-devices and the application sewers (AS) involved in communication. The best user experience is targeted under real-time variation of available network (e.g. bandwidth, buffer space) and end-device (e.g. battery, CPU, memory, storage) resources throughout a session. The multimedia content is dynamically adapted to$t the resource availability variations, achieving maximum system (i.e. network and end-devices) resource utilization and enhanced QoS. The resource availability update signalling is carried over Session Initiation Protocol (SIP) during the session. This is work in progress.
Epigenetic regulation of normal human mammary cell type–specific miRNAs (2011)

Epigenetic mechanisms are important regulators of cell type-specific genes, including miRNAs. In order to identify cell type-specific miRNAs regulated by epigenetic mechanisms, we undertook a global analysis of miRNA expression and epigenetic states in three isogenic pairs of human mammary epithelial cells (HMEC) and human mammary fibroblasts (HMF), which represent two differentiated cell types typically present within a given organ, each with a distinct phenotype and a distinct epigenotype. While miRNA expression and epigenetic states showed strong interindividual concordance within a given cell type, almost 10% of the expressed miRNA showed a cell type-specific pattern of expression that was linked to the epigenetic state of their promoter. The tissue-specific miRNA genes were epigenetically repressed in nonexpressing cells by DNA methylation (38%) and H3K27me3 (58%), with only a small set of miRNAs (21%) showing a dual epigenetic repression where both DNA methylation and H3K27me3 were present at their promoters, such as MIR10A and MIR10B. Individual miRNA clusters of closely related miRNA gene families can each display cell type-specific repression by the same or complementary epigenetic mechanisms, such as the MIR200 family, and MIR205, where fibroblasts repress MIR200C/141 by DNA methylation, MIR200A/200B/429 by H3K27me3, and MIR205 by both DNA methylation and H3K27me3. Since deregulation of many of the epigenetically regulated miRNAs that we identified have been linked to disease processes such as cancer, it is predicted that compromise of the epigenetic control mechanisms is important for this process. Overall, these results highlight the importance of epigenetic regulation in the control of normal cell type-specific miRNA expression.
Anticholinesterase activity of a new carbamate, heptylphysostigmine, in view of its use in patients with Alzheimer-type dementia (1986)

The anticholinesterase activity of a new carbamate, heptylphysostigmine, was studied in vitro. This compound is a competitive inhibitor of acetylcholinesterase (or true cholinesterase) having Ki = (1 +/- 0.5) X 10(-7) M. The inhibition was instantaneous at the onset and did not diminish with prolonged incubation of the drug and enzyme.
Aircraft Engine Gas Path Diagnostic Methods: Public Benchmarking Results (2013)

Recent technology reviews have identified the need for objective assessments of aircraft engine health management (EHM) technologies. To help address this issue, a gas path diagnostic benchmark problem has been created and made publicly available. This software tool, referred to as the Propulsion Diagnostic Method Evaluation Strategy (ProDiMES), has been constructed based on feedback provided by the aircraft EHM community. It provides a standard benchmark problem enabling users to develop, evaluate, and compare diagnostic methods. This paper will present an overview of ProDiMES along with a description of four gas path diagnostic methods developed and applied to the problem. These methods, which include analytical and empirical diagnostic techniques, will be described and associated blind-test-case metric results will be presented and compared. Lessons learned along with recommendations for improving the public benchmarking processes will also be presented and discussed.
Gene signature and prognostic value of ubiquitination-related genes in endometrial cancer (2023)

Protein ubiquitination is closely related to tumor occurrence and development. The specific role of ubiquitination in endometrial cancer remains largely unclear. Therefore, we constructed a novel endometrial cancer prognostic model based on ubiquitination-related genes. We extracted the expression matrices of ubiquitination-related genes from the Cancer Genome Atlas database, upon which we performed univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses to obtain 22 ubiquitination-related genes for the construction of the prognostic model. Survival, regression, clinical correlation, and principal component analyses were performed to assess the performance of the model. Drug sensitivity analysis was performed based on these ubiquitination-related genes. Finally, a prognostic nomogram was constructed based on the prognostic model to quantify patient outcomes. Survival, regression, clinical correlation, and principal component analyses revealed that the performance of the prognostic model was satisfactory. Drug sensitivity analysis provided a potential direction for the treatment of endometrial cancer. The prognostic nomogram could be used to effectively estimate the survival rate of patients with endometrial cancer. In summary, we constructed a new endometrial cancer prognostic model and identified 5 differentially expressed, prognosis-associated, ubiquitination-related genes. These 5 genes are potential diagnostic and treatment targets for endometrial cancer.
Glutathione S-transferase genotypes modify lung function decline in the general population: SAPALDIA cohort study (2007)

Our results suggest that genetic GSTT1 deficiency is a prevalent and strong determinant of accelerated lung function decline in the male general population.
A Roadmap for Autostereoscopic Multi-Viewer Domestic TV Displays (2006)

This paper presents a brief overview of the current technologies and technical approaches that may lead to viable and user-acceptable domestic autostereoscopic multi-viewer television displays. It illustrates the performance attributes of the various technological approaches and points to the most likely approaches to succeed within the next 10 years. Finally, it shows possible timescales for the enabling technologies for 3D display, and concludes that multi-user autostereoscopic displays may be the first to gain widespread use
Founding, Foraging, and Fighting: Colony Size and the Spatial Distribution of Harvester Ant Nests (1996)

This study examines how the spatial distribution of nests is related to the behavioral interactions of conspecific neighbors in a population of the seed—eating ant, Pogonomyrmex barbatus. Colonies live for 15—20 yr, reaching reproductive age and a stable size at $\approx$5 yr. Spatial distributions were measured for 6 yr (1988—1993) in a population of $\approx$250 colonies of known age. The probability that a 1—yr—old colony occurs in a given location is related to the distance to, and ages of, its five nearest conspecific neighbors. One—year—old colonies are most likely to occur near small, 2— and 3—yr—old colonies. Neighboring colonies encounter each other when foragers of both colonies search the same area on the same day. The probability of an encounter between two colonies decreases with the distance between their nests. For colonies of all ages, encounters are most likely with their larger neighbors, $\geq 5$ yr old. Encounters are more likely if there was an encounter the previous day, and this effect can overwhelm the effect of distance. Two—yr—old colonies are more likely than colonies of other ages to lose ground in repeated encounters with a particular neighbor. Though encounters are frequent, their costs are low: few of the foragers on a trail that meets a neighbor's actually encounter an ant of the neighboring colony, and interaction with a neighboring colony does not increase the typical duration of a foraging trip. If foragers of two colonies do meet, most fights are brief, with few resulting in injury or death. These results suggest that the cost of conspecific neighbors searching the same ground for seeds may be greater than the cost of behavioral interaction itself. Exploitative competition may have more important effects than interference competition on founding colony survival and thus on the spatial distribution of nests.
EXPRESSION OF CRIPTO IN HUMAN GALL BLADDER LESIONS (1996)

The expression of cripto, a member of the epidermal growth factor (EGF) family, was examined by immunohistochemistry in benign lesions and carcinomas of the gall bladder. Cripto expression was detected in 6 (67 per cent) of 9 hyperplasias, 4 (58 per cent) of 7 adenomas, and 89 (68 per cent) of 132 adenocarcinomas of the gall bladder. The degree of cripto expression was not correlated with depth of tumour invasion, tumour stage or patient prognosis. The incidence of cases with cripto expression was significantly higher in papillary and well-differentiated adenocarcinomas (positive 73 per cent; strongly positive 38 per cent) than in moderately and poorly differentiated adenocarcinomas (positive 54 per cent; strongly positive 17 per cent) (P<0·05). These results suggest that cripto expression may not relate to progression in gall bladder carcinomas, but may be associated with tumour differentiation.
Severe Cerebral Desaturation During Shoulder Arthroscopy in the Beach‐Chair Position (2010)

During shoulder arthroscopy in the beach-chair position, cerebral ischemia may be a serious complication because prolonged hypotension may affect regional cerebral oxygen supply. We present the cases of 2 patients in whom a reduction in mean arterial pressure after anesthesia provoked a decrease in frontal lobe oxygenation to below the level that causes presyncopal symptoms in the awake subject. In the healthy middle-aged patient, cerebral oxygenation decreased by approximately 40%, indicating that cerebral blood flow was markedly reduced, and intravenous administration of ephedrine rapidly restored cerebral oxygenation. During surgery in the beach-chair position, hypotension must be avoided, and in all patients regional, cerebral oxygenation should be monitored and optimized.
Liver Planning Software Accurately Predicts Postoperative Liver Volume and Measures Early Regeneration (2014)

Preoperative virtual planning of future liver remnant accurately predicts postoperative volume after hepatic resection. Early postoperative liver regeneration is measureable on imaging beginning at 5 days after surgery. Measuring TLV directly from CT scans rather than calculating based on equations accounts for extremes in TLV.