gebhart/patrepeval huggingface dataset:
Coiled tubing. operations and services (1992)

Coiled tubing is being used with increasing frequency in conventional or traditional production operations. Demand for coiled pipe in these types of applications is expected to experience rapid growth as standard 2 (3/8) and 2 (7/8)-in. OD tubing sizes and units equipped to run larger pipe become more readily available. This paper reports on a recent market survey which indicated that coiled tubing used for velocity strings and standard production tubing installations are two areas with the most potential for immediate and near-term expansion. Other applications include: well casing and liners, gravel packing, artificial lift, flowlines and pipelines.
On Associations of Light and Sound: The Mediation of Brightness, Pitch, and Loudness (1974)

Subjects searched for pure tones to match the brightnesses of gray surfaces. Nearly all repeatedly set increasing pitch to increasing brightness; some set increasing loudness to increasing brightness, while others set it to increasing darkness; and most, when brightness was held constant, offset increasing pitch by decreasing loudness. The results mimic those of synesthesia and suggest that most subjects may match auditory to visual brightnesses. The system that mediates these cross-modal equivalences is unknown but may best be thought of as a cognitive mechanism that is capable of manipulating dimensions of sensory experience.
Roles of IFN Consensus Sequence Binding Protein and PU.1 in Regulating IL-18 Gene Expression (1999)

IL-18 is expressed from a variety of cell types. Two promoters located upstream of exon 1 (5'-flanking region) and upstream of exon 2 (intron 1) regulate its expression. Both promoter regions were cloned into pCAT-Basic plasmid to yield p1-2686 for the 5'-flanking promoter and p2-2.3 for the intron 1 promoter. Both promoters showed basal constitutive activity and LPS inducibility when transfected into RAW 264.7 macrophages. To learn the regulatory elements of both promoters, 5'-serial deletion and site-directed mutants were prepared. For the activity of the p1-2686 promoter, the IFN consensus sequence binding protein (ICSBP) binding site between -39 and -22 was critical. EMSA using an oligonucleotide probe encompassing the ICSBP binding site showed that LPS treatment increased the formation of DNA binding complex. In addition, when supershift assays were performed, retardation of the protein-DNA complex was seen after the addition of anti-ICSBP Ab. For the activity of the p2-2.3 promoter, the PU.1 binding site between -31 and -13 was important. EMSA using a PU.1-specific oligonucleotide demonstrated that LPS treatment increased PU.1 binding activity. The addition of PU.1-specific Ab to LPS-treated nuclear extracts resulted in the formation of a supershifted complex. Furthermore, cotransfection of ICSBP or PU.1 expression vector increased p1 promoter activity or IL-18 expression, respectively. Taken together, these results indicate that ICSBP and PU.1 are critical elements for IL-18 gene expression.
Hair diameter diversity: a clinical sign reflecting the follicle miniaturization. (2001)

Considering that hair follicle miniaturization is the key point during androgenic alopecia onset and development, diversity in hair diameter represents an important feature to consider as an accurate clinical sign reflecting hair follicle miniaturization. Moreover, diversity in hair diameter seems to be an easily accessible and reliable parameter that should be taken into consideration for further characterization of hair disorders. By itself, we believe that this clinical feature constitutes a new tool of substantial help for the diagnosis and management of androgenic alopecia.
Graphical Models and Iterative Decoding (2000)

Since the invention of turbo codes, there has been a lot of interest in iterative decoding schemes.It is also known that the turbo decoding algorithm and several other previously known iterative algorithms are instances of Pearl's belief propagation algorithm applied to a graph with cycles, while the algorithm is known to work only for graphs without cycles. We describe a marginalization algorithm which works on junction trees, which is based on some newer developments in Bayesian networks. This is sufficiently general that Pearl's belief propagation and decoding on Tanner graphs may be regarded as special cases. An attempt to compute the discrete Fourier transform as a marginalization problem in this framework gives the fast Fourier transform algorithm, thus showing that this framework has applications apart from probabilistic computations. Junction graphs with cycles lead to an iterative algorithm. The case of junction graphs with a single cycle is analyzed, with specific results in the case of the sum-product algorithm. We also have some experimental results for small turbo code-like junction graphs.

On a different topic, we consider the typical set decoder, which can be used to obtain bounds on the noise threshold for asymptotically error free decoding, for given code ensembles. Some choices of the typical set for AWGN channel are considered and the resulting bounds on the threshold obtained.
Wave propagation in nonlinear left-handed transmission line media (2005)

Using a one-dimensional system, we demonstrate a wide variety of wave propagation phenomena possible in nonlinear left-handed media. These include effective second-harmonic generation where the fundamental wave and the second-harmonic wave are badly mismatched. We also observe parametric instabilities accompanying intensive harmonic generation.
HDAC6 and Ubp-M BUZ Domains Recognize Specific C-Terminal Sequences of Proteins (2010)

The BUZ/Znf-UBP domain is a protein module found in the cytoplasmic deacetylase HDAC6, E3 ubiquitin ligase BRAP2/IMP, and a subfamily of ubiquitin-specific proteases. Although several BUZ domains have been shown to bind ubiquitin with high affinity by recognizing its C-terminal sequence (RLRGG-COOH), it is currently unknown whether the interaction is sequence-specific or whether the BUZ domains are capable of binding to proteins other than ubiquitin. In this work, the BUZ domains of HDAC6 and Ubp-M were subjected to screening against a one-bead-one-compound (OBOC) peptide library that exhibited random peptide sequences with free C-termini. Sequence analysis of the selected binding peptides as well as alanine scanning studies revealed that the BUZ domains require a C-terminal Gly-Gly motif for binding. At the more N-terminal positions, the two BUZ domains have distinct sequence specificities, allowing them to bind to different peptides and/or proteins. A database search of the human proteome on the basis of the BUZ domain specificities identified 11 and 24 potential partner proteins for Ubp-M and HDAC6 BUZ domains, respectively. Peptides corresponding to the C-terminal sequences of four of the predicted binding partners (FBXO11, histone H4, PTOV1, and FAT10) were synthesized and tested for binding to the BUZ domains by fluorescence polarization. All four peptides bound to the HDAC6 BUZ domain with low micromolar K(D) values and less tightly to the Ubp-M BUZ domain. Finally, in vitro pull-down assays showed that the Ubp-M BUZ domain was capable of binding to the histone H3-histone H4 tetramer protein complex. Our results suggest that BUZ domains are sequence-specific protein-binding modules, with each BUZ domain potentially binding to a different subset of proteins.
Gene and miRNA expression changes in squamous cell carcinoma of larynx and hypopharynx (2015)

Laryngo-pharyngeal squamous cell carcinomas are one of the most common head and neck cancers. Despite the presence of a large body of information, molecular biomarkers are not currently used in the diagnosis, treatment and management of patients for this group of cancer. Here, we have profiled expression of genes and microRNAs of larynx and hypopharynx tumors using high-throughput sequencing experiments. We found that matrix metalloproteinases along with SCEL, CRNN, KRT4, SPINK5, and TGM3 among others have significantly altered expression in these tumors. Alongside gene expression, the microRNAs hsa-miR-139, hsa-miR-203 and the hsa-miR-424/503 cluster have aberrant expression in these cancers. Using target genes for these microRNAs, we found the involvement of pathways linked to cell cycle, p53 signaling, and viral carcinogenesis significant (P-values 10 -13 , 10 -9 and 10 -7 respectively). Finally, using an ensemble machine-learning tool, we discovered a unique 8-gene signature for this group of cancers that differentiates the group from the other tumor subsites of head and neck region. We investigated the role of promoter methylation in one of these genes, WIF1, and found no correlation between DNA methylation and down-regulation of WIF1. We validated our findings of gene expression, 8-gene signature and promoter methylation using q-PCR, data from TCGA and q-MSP respectively.
Behaviour-Based Anomaly Detection of Cyber-Physical Attacks on a Robotic Vehicle (2016)

Security is one of the key challenges in cyberphysical systems, because by their nature, any cyber attack against them can have physical repercussions. This is a critical issue for autonomous vehicles; if compromised in terms of their communications or computation they can cause considerable physical damage due to their mobility. Our aim here is to facilitate the automatic detection of cyber attacks on a robotic vehicle. For this purpose, we have developed a detection mechanism, which monitors real-time data from a large number of sources onboard the vehicle, including its sensors, networks and processing. Following a learning phase, where the vehicle is trained in a non-attack state on what values are considered normal, it is then subjected to a series of different cyber-physical and physical-cyber attacks. We approach the problem as a binary classification problem of whether the robot is able to self-detect when and whether it is under attack. Our experimental results show that the approach is promising for most attacks that the vehicle is subjected to. We further improve its performance by using weights that accentuate the anomalies that are less common thus improving overall performance of the detection mechanism for unknown attacks.
Detection of Primary Breast Carcinoma with a Dedicated, Large-Field-of-View FDG PET Mammography Device: Initial Experience (2005)

These pilot data suggest that PET mammography can demonstrate small primary breast malignancies.
Magnetic properties of N-doped graphene with high Curie temperature (2016)

N-doped graphene with Curie temperature higher than room temperature is a good candidate for nanomagnetic applications. Here we report a kind of N-doped graphene that exhibits ferromagnetic property with high Curie temperature (>600 K). Four graphene samples were prepared through self-propagating high-temperature synthesis (SHS), and the doped nitrogen contents of in the samples were 0 at.%, 2.53 at.%, 9.21 at.% and 11.17 at.%. It has been found that the saturation magnetization and coercive field increase with the increasing of nitrogen contents in the samples. For the sample with the highest nitrogen content, the saturation magnetizations reach 0.282 emu/g at 10 K and 0.148 emu/g at 300 K; the coercive forces reach 544.2 Oe at 10 K and 168.8 Oe at 300 K. The drop of magnetic susceptibility at ~625 K for N-doped graphene is mainly caused by the decomposition of pyrrolic N and pydinic N. Our results suggest that SHS method is an effective and high-throughput method to produce N-doped graphene with high nitrogen concentration and that N-doped graphene produced by SHS method is promising to be a good candidate for nanomagnetic applications.
Nicorandil Treatment in Patients With Acute Myocardial Infarction A Meta-Analysis (2009)

The meta-analysis demonstrated that nicorandil treatment adjunctive to reperfusion therapy has beneficial effects on microvascular function and on functional recovery after AMI.
Gbit/in/sup 2/ perpendicular recording using double layer medium and MIG head (1996)

Perpendicular recording has been studied using ring heads for read and write. It was confirmed that an areal recording density of 1 Gbit/in/sup 2/ could be achieved by using a MIG type ring head for recording and a narrow gap ring head for reproduction combined with a single layer Co-Cr system alloy medium with a thin soft magnetic backlayer. Improvement in overwrite properties with the backlayer and noise reduction by increasing the Cr content are discussed. It is concluded that it would be possible to realize a 10 Gbit/in/sup 2/ recording system by perpendicular recording by using a high resolution MR head without any fundamental changes in the medium.
Zr–Zeolite Beta: A New Heterogeneous Catalyst System for the Highly Selective Cascade Transformation of Citral to (±)‐Menthol (2009)

The transformation of citral to menthols involves hydrogenation steps as well as cyclisation of the intermediate, citronellal. The ability of Zr-zeolite beta to catalyse the cyclisation with high diastereoselectivity to (+/-)-isopulegol is the critical step in this cascade transformation. Bifunctional catalysts containing nickel or rhodium supported on Zr-zeolite beta gave menthols in yields of 87-89% and an excellent diastereoselectivity of 94% for the desired (+/-)-menthol. Dual catalyst systems of Zr-zeolite beta and nano-dispersed Ni on an MCM-41 support were equally effective and have the added advantage that the rates of the acid- and hydrogenation-catalysed steps can be independently varied. By applying a pressure ramp of 0.2-2 MPa, the yield of menthols could be increased to 95%, with 94% diastereoselectivity for (+/-)-menthol. The low initial pressure minimises the rates of competing hydrogenation reactions to byproducts such as citronellol and 3,7-dimethyloctanol.
Reaction of [Ir(cyclo-octa-1,5-diene){P(p-tolyl)<sub>3</sub>}<sub>2</sub>][nido-7,8-C<sub>2</sub>B<sub>9</sub>H<sub>12</sub>] with hydrogen; synthesis and X-ray structure of 3,9-[(H)<sub>2</sub>{P(p-tolyl)<sub>3</sub>}<sub>2</sub>Ir]-3,9-µ-(H)<sub>2</sub>-7,8-C<sub>2</sub>B<sub>9</sub>H<sub>10</sub> (1980)

Treatment of the ion pair, [Ir(cod)(PR3)2][nido-7,8-C2B9H12](cod = cyclo-octa-1,5-diene; R = phenyl, p-tolyl) with hydrogen gave closo-3,3-(PR3)2-3-H-3,1,2-IrC2B9H11 and the novel nido-metallocarbaborane, 3,9-[cis-(H)2-trans-(PR3)2-Ir]-3,9-µ-(H)2-nido-7,8-C2B9H10.
Depth Enhanced Panoramas (2005)

We describe a method for interactive modeling and visualization of room-size indoor scenes that is fast, easy, and inexpensive. We have designed a novel data acquisition device, called a ModelCamera, that consists of a video camera with an attached laser system that generates a 7x7 pattern of depth samples. The operator pans and tilts the ModelCamera around the camera's center of projection and it acquires a sequence of color and depth frames. The frames are registered in world coordinates and are merged into an evolving scene model, called a depth enhanced panorama. The model is visualized continually; the immediate feedback allows the operator to monitor the model quality and to identify missing scene surfaces. Our approach extends color panoramas to support viewpoint translation, while retaining their speed, convenience, and low cost (Figure 1). It is a practical alternative to modeling systems that provide complete models at a high cost.
Comparison of immunofluorescence and immunoperoxidase methods for viral diagnosis at a distance: a WHO collaborative study. (1978)

Nasopharyngeal secretions collected in Newcastle were examined in both Newcastle and Stockholm for the presence of influenza virus type A and respiratory syncytial (RS) virus by immunofluorescence and immunoperoxidase techniques. A total of 139 specimens were examined in this way and the agreement between the two centres for immunofluorescence was 94% for influenza virus A, 95% for respiratory syncytial virus, and 95% for negative specimens. This technique can therefore be used for examining specimens taken at great distances from the collecting laboratory. The results of the immunoperoxidase technique were unsatisfactory mainly because of the presence of endogenous peroxidase. Measures taken to remove this also destroyed RS virus antigen. It is premature to introduce the immunoperoxidase technique for rapid virus diagnosis, but in due course, when the problems outlined in this article are solved, it could become a useful technique.
ULTRACYTOCHEMISTRY OF MITOSIS (1973)

The changes of the organelles during mitosis were observed in hepatic parenchymal cells after partial hepatectomy. The endoplasmic reticulum plays a roll to form nuclear envelope of dauthter nuclei at early telophase. The Golgi apparatus shows a dynamic morphological changes during mitosis. The number of the peroxisomes decreased before the onset of first cell division. The marker enzymes of those organelles, glucose-6-phosphatase for endoplasmic reticulum, thiamine pyrophosphatase for Golgi apparatus, Peroxidase for peroxisome, helps great deal to identify the organelles especially which show dynamic changes of morphology.
Breaking the copy/paste cycle: the Stretchable Selection Tool (2002)

Copy-and-paste, or cut-and-paste, using a clipboard or paste buffer, has long been the principle facility provided to users for transferring data between and within GUI applications. We argue that this mechanism can be clumsy in circumstances where several pieces information must be moved systematically-for example, extracting a predetermined set of data fields from a piece of unstructured text. In dealing with the plethora of potentially useful, but not appropriately structured, information on the World Wide Web, interfaces which facilitate manual information gathering are of considerable importance. We present an alternative, more natural user interface facility to make the task less onerous, and to provide improved visual feedback during the operation. We call our facility the "Stretchable Selection Tool", a semi-transparent overlay augmenting the mouse pointer to automate paste operations and provide information to prompt the user. We describe a prototype implementation that functions in a collaborative software environment, allowing users to cooperate on multiple copy/paste operations.
Identification of Practices and Capabilities in API Management: A Systematic Literature Review (2020)

Traditional organizations are increasingly becoming software producing organizations. This software is enabling them to integrate business processes between different departments and with other organizations through Application Programming Interfaces (APIs). The main task of managing APIs is to ensure that the APIs are easy to use by third parties, such as providing helpful documentation, monitoring API performance, and even monetizing API usage. The knowledge on API management is scattered across academic literature. In this document, we describe a Systematic Literature Review (SLR) that has the goal of collecting API Management practices and capabilities related to API Management, as well as proposing a comprehensive definition of the topic. In the scope of this work, a practice is defined as any practice that has the express goal to improve, encourage and manage the usage of APIs. Capabilities are defined as the ability to achieve a certain goal related to API Management, through the execution of two or more interrelated practices. We follow a standard method for SLRs in software engineering. We managed to collect 24 unique definitions for the topic, 114 practices and 39 capabilities.
Proteolytic Degradation of Human Antimicrobial Peptide LL-37 by <i>Bacillus anthracis</i> May Contribute to Virulence (2006)

In this paper we report on the susceptibilities of a range of Bacillus species to the human antimicrobial peptide LL-37. B. subtilis showed a low level of resistance to killing by LL-37 (50% growth-inhibitory concentration [GI50], 1 microg/ml). B. cereus and B. thuringiensis showed intermediate levels of resistance to killing (GI50s, 33 microg/ml and 37 microg/ml, respectively). B. anthracis showed the highest level of resistance (GI50s, 40 to 66 microg/ml). The degradation of LL-37 by B. anthracis culture supernatant was blocked by the metalloprotease inhibitors EDTA and 1,10-phenanthroline, and the gene encoding the protease responsible for LL-37 degradation was not plasmid borne. Our findings suggest that alongside the classical plasmid-based virulence determinants, extracellular metalloproteases of B. anthracis may play a role in survival in the host.
Development of humoral immune responses against a macrocyclic chelating agent (DOTA) in cancer patients receiving radioimmunoconjugates for imaging and therapy. (1992)

The development of stable immunoconjugates by the advent of macrocyclic metal chelating agents (DOTA) has enabled us to study the ability of 111In-DOTA-labeled monoclonal antibodies to detect tumor lesions in a pilot radioimmunolocalization study, as well as to evaluate the kinetics, toxicity, and efficacy of i.p. administered 90Y-DOTA-labeled murine monoclonal antibody in a Phase I/II clinical trial of advanced ovarian cancer. The development of serum sickness-like reactions in three of six treated patients, in the absence of previous monoclonal antibody administration, led us to study the potential immunogenicity of the new chelate. Six patients with ovarian cancer received 25 mg of HMFG1 monoclonal antibody coupled with 90Y-DOTA (doses of radioactivity, 15 to 25 mCi), administered i.p. Eight patients with various malignant tumors received low doses (220 micrograms to 1 mg) of monoclonal antibodies, labeled with 111In-DOTA, i.v. for imaging studies. Using a solid-phase enzyme-linked immunosorbent assay method, the immunogenicity of DOTA was evaluated. Serial dilutions of patients' sera, before and after imaging or therapy with DOTA-coupled monoclonal antibodies, as well as sera from patients who did not receive DOTA-coupled antibody, were screened on enzyme-linked immunosorbent assay plates coated with human serum albumin (HSA), HSA-2-iminothiolane, and HSA-2-iminothiolane-benzyl-DOTA. All patients treated with i.p. monoclonal antibody developed anti-DOTA antibodies. Four of eight patients who received i.v. "imaging" doses of DOTA-coupled monoclonal antibody developed antibodies against DOTA. The levels of anti-DOTA response correlated with the amount of injected radioimmunoconjugate (r = 0.889, P less than 0.001). None of the patients who received DOTA-coupled antibody had detectable antibodies against the macrocycle before immunoconjugate administration. We then addressed further the restriction of the immune response against the macrocycle. We found that there was no or very low response against the aromatic ring attached to DOTA. Most, if not all, of the immune response is directed against the DOTA ring structure. Affinity purification of anti-DOTA antibody from serum enabled quantitation of these antibodies in the serum of patients. An inverse, statistically significant correlation was observed between the percentage of binding inhibition of a patient's serum to DOTA, by HSA-2-iminothiolane-DOTA (100 micrograms/ml) and the level of anti-DOTA immunoglobulin in the serum.(ABSTRACT TRUNCATED AT 400 WORDS)
Redox‐Active Metal–Organic Composites for Highly Selective Oxygen Separation Applications (2016)

A redox-active metal-organic composite material shows improved and selective O2 adsorption over N2 with respect to individual components (MIL-101 and ferrocene). The O2 sensitivity of the composite material arises due to the formation of maghemite nanoparticles with the pore of the metal-organic framework material.
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis (2016)

At moderate doses, celecoxib was found to be noninferior to ibuprofen or naproxen with regard to cardiovascular safety. (Funded by Pfizer; ClinicalTrials.gov number, NCT00346216 .).