gebhart/patrepeval huggingface dataset:
Dynamic coordination architecture through the use of reflection (2001)

Article Share on Dynamic coordination architecture through the use of reflection Authors: Carlos E. Cuesta Departamento de Informática, Universidad de Valladolid, Valladolid 47011, Spain Departamento de Informática, Universidad de Valladolid, Valladolid 47011, SpainView Profile , Pablo de la Fuente Departamento de Informática, Universidad de Valladolid, Valladolid 47011, Spain Departamento de Informática, Universidad de Valladolid, Valladolid 47011, SpainView Profile , Manuel Barrio-Solárzano Departamento de Informática, Universidad de Valladolid, Valladolid 47011, Spain Departamento de Informática, Universidad de Valladolid, Valladolid 47011, SpainView Profile Authors Info & Claims SAC '01: Proceedings of the 2001 ACM symposium on Applied computingMarch 2001 Pages 134–140https://doi.org/10.1145/372202.372298Online:01 March 2001Publication History 40citation945DownloadsMetricsTotal Citations40Total Downloads945Last 12 Months8Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A Temporal Reasoning based Social Calendar Framework (2014)

Electronic calendar has been intensively used in people’s life and work. In recent years it is popularized in the context of social networks, which forced the emergence of social calendar. For social calendar people is not just satisfied with creating, storing and exchanging their schedule data, they wants to use the calendar as a social network app, send invitations on some scheduled events, flexibly define the access rules on their scheduling, and even create event agenda in team manner. This paper describes a framework to answer those requirements. Using the standard interoperaterable calendar data format - iCalendar as calendar representation, the framework compiles the event information into an internal network structure, and incorporates a MapReduce consistency algorithm - that makes the framework suitable for large scale data processing in social network context.
Application of spatial light modulators for new modalities in spectrometry and imaging (2003)

We have constructed an adaptive digitally tuned light source in the form of a de-dispersive imaging spectrograph in both the visible and near infrared spectral regions capable of illuminating a sample with appropriate energy weighted spectral bands or spatio-spectral bands that relate only to the constituents of interest to the investigator. The energy from each of the spectral resolution elements can be digitally modulated to provide a tuned weighted spectral output. A tuned light source based on this technology was adapted for use in a conventional imaging microscope system to enable direct measure of spatio-spectral features of interest. Some imagery resulting from preliminary tests on colon tissue biopsies are presented.
Reversible hydrogels with tunable mechanical properties for optically controlling cell migration (2017)

Synthetic hydrogels are widely used as biomimetic in vitro model systems to understand how cells respond to complex microenvironments. The mechanical properties of hydrogels are deterministic for many cellular behaviors, including cell migration, spreading, and differentiation. However, it remains a major challenge to engineer hydrogels that recapture the dynamic mechanical properties of native extracellular matrices. Here, we provide a new hydrogel platform with spatiotemporally tunable mechanical properties to assay and define cellular behaviors under light. The change in the mechanical properties of the hydrogel is effected by a photo-induced switch of the cross-linker fluorescent protein, Dronpa145N, between the tetrameric and monomeric states, which causes minimal changes to the chemical properties of the hydrogel. The mechanical properties can be rapidly and reversibly tuned for multiple cycles using visible light, as confirmed by rheological measurements and atomic force microscopybased nano-indentation. We further demonstrated real-time and reversible modulation of cell migration behaviors on the hydrogels through photo-induced stiffness switching, with minimal invasion to the cultured cells. Hydrogels with a programmable mechanical history and a spatially defined mechanical hierarchy might serve as an ideal model system to better understand complex cellular functions.
Rapid neutrophil accumulation and protein oxidation in irradiated rat lungs (1994)

Exposure of lungs to high doses of ionizing radiation can initiate an injurious acute inflammatory response. We show that neutrophil content in the lungs of rats exposed to 10 Gy whole body gamma radiation increased threefold 4.5 h after irradiation and returned to normal by 24 h. Oxidized methionine in the proteins of the lungs, heart, liver, kidney, and jejunum increased significantly in 2 h. Treatment with the antioxidant dithiothreitol immediately after irradiation prevented methionine oxidation. Methionine oxidation was also observed after intrabronchial instillation of phorbol myristate acetate, a model of neutrophil oxidant-mediated pulmonary injury, as well as in isolated lungs perfused with hypochlorous acid, confirming the ability of neutrophil oxidants to cause protein oxidation in lungs. No change in glutathione or protein sulfhydryl content was detected in irradiated lungs 4.5 h after irradiation, possibly as a result of protection by the observed increase in pulmonary glutathione reductase. We therefore show that the acute pulmonary inflammatory response to radiation involves rapid neutrophil accumulation, oxidant production, and protein oxidation.
Deconstructing the “First Moment of Truth”: Understanding Unplanned Consideration and Purchase Conversion Using In-Store Video Tracking (2013)

Retailers and manufacturers are keenly interested in understanding unplanned consideration and purchase conversion, but data that capture in-store product consideration have been unavailable in the past. In the current research, the authors use in-store video tracking to collect a novel data set that records shopping behavior at the point of purchase, including product consideration. In conjunction with an entrance survey of purchase intentions, they conduct several descriptive analyses that focus on the incidence, category propensity, behavioral characteristics, and outcome of unplanned consideration. The results reveal several new empirical insights. First, the authors find significant category-level complementarities between planned items and unplanned considerations, which they capture using a latent category map. Second, planned consideration and unplanned consideration differ in key behavioral characteristics (e.g., likelihood of purchase, time of occurrence, number of product touches). Third, greater likelihood of purchase conversion is significantly associated with dynamic factors (e.g., remaining in-store slack, outcome of the previous consideration) and behavioral characteristics (e.g., number of displays viewed, distance to shelf, references to a shopping list). The authors conclude with a discussion of implications of these findings for research and shopper marketing.
Hypertonic saline dextran resuscitation during the initial phase of acute endotoxemia (1991)

Small-volume resuscitation by means of hypertonic saline-dextran proved the most effective, and seems to be an attractive supportive therapy to prevent microcirculatory failure in sepsis and endotoxemia.
C5a Receptor Targeting in Neointima Formation After Arterial Injury in Atherosclerosis-Prone Mice (2010)

One-week treatment with C5aRA or anti-C5aR-blocking monoclonal antibody limited neointimal hyperplasia and inflammatory cell content and was associated with reduced vascular cell adhesion molecule-1 expression. However, treatment for 3 weeks failed to reduce but rather stabilized plaques, likely by reducing vascular plasminogen activator inhibitor-1 and increasing vascular smooth muscle cell migration.
[The expression of multiple drug resistance associated genes in ovarian cancer]. (2000)

Multiple gene expression is involved in drug resistance in ovarian cancer. The co-expression of MDR1, MRP, LRP and GST-pi is higher in ovarian cancer than that in benign ovarian tumor and normal ovary tissue. The expression of MDR1 and MRP is closely related to the tumor differentiation and the response to chemotherapy.
Vertically Aligned and Electronically Coupled Growth Induced InAs Islands in GaAs (1996)

Multilayer, vertically coupled, quantum dot structures are investigated using layers composed of InAs islands grown by molecular beam epitaxy in the Stranski-Krastanov growth mode. Single, 2, 5, and 10 InAs island layers are investigated in which the 40 \AA{} high InAs islands are separated by 56 \AA{} GaAs spacer layers. The InAs islands are vertically aligned in columns and are pseudomorphic. Between 1 and 10 layers of islands, 8 K photoluminescence shows a 25% reduction in PL linewidth, and a peak shift of 92 meV to lower energy, while transmission electron and atomic force microscopy show the island size in different layers remains constant. These effects are attributed to electronic coupling between islands in the columns, and a simple coupling model is used to simultaneously fit the spectral peak position shift and the linewidth changes.
Genetic Variation in Prostate-Specific Antigen–Detected Prostate Cancer and the Effect of Control Selection on Genetic Association Studies (2014)

These findings highlight the need for inferences from genetic studies of prostate cancer risk to carefully consider the influence of control selection criteria.
Human Neural Stem Cell Tropism to Metastatic Breast Cancer (2011)

Metastasis to multiple organs is the primary cause of mortality in breast cancer patients. The poor prognosis for patients with metastatic breast cancer and toxic side effects of currently available treatments necessitate the development of effective tumor-selective therapies. Neural stem cells (NSCs) possess inherent tumor tropic properties that enable them to overcome many obstacles of drug delivery that limit effective chemotherapy strategies for breast cancer. We report that increased NSC tropism to breast tumor cell lines is strongly correlated with the invasiveness of cancer cells. Interleukin 6 (IL-6) was identified as a major cytokine mediating NSC tropism to invasive breast cancer cells. We show for the first time in a preclinical mouse model of metastatic human breast cancer that NSCs preferentially target tumor metastases in multiple organs, including liver, lung, lymph nodes, and femur, versus the primary intramammary fat pad tumor. For proof-of-concept of stem cell-mediated breast cancer therapy, NSCs were genetically modified to secrete rabbit carboxylesterase (rCE), an enzyme that activates the CPT-11 prodrug to SN-38, a potent topoisomerase I inhibitor, to effect tumor-localized chemotherapy. In vitro data demonstrate that exposure of breast cancer cells to conditioned media from rCE-secreting NSCs (NSC.rCE) increased their sensitivity to CPT-11 by 200-fold. In vivo, treatment of tumor-bearing mice with NSC.rCE cells in combination with CPT-11 resulted in reduction of metastatic tumor burden in lung and lymph nodes. These data suggest that NSC-mediated enzyme/prodrug therapy may be more effective and less toxic than currently available chemotherapy strategies for breast cancer metastases.
Inelastic neutron scattering study of the spin-gap cuprate<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi>β</mml:mi><mml:mtext>−</mml:mtext><mml:mi mathvariant="normal">Ag</mml:mi><mml:mi mathvariant="normal">Cu</mml:mi><mml:mi mathvariant="normal">P</mml:mi><mml:msub><mml:mi mathvariant="normal">O</mml:mi><mml:mn>4</mml:mn></mml:msub></mml:mrow></mml:math> (2007)

We studied magnetism of $\ensuremath{\beta}\text{\ensuremath{-}}\mathrm{Ag}\mathrm{Cu}\mathrm{P}{\mathrm{O}}_{4}$ using inelastic neutron scattering and magnetic susceptibility measurements on powder samples. A well-defined asymmetric broad inelastic peak was observed at $6.2\phantom{\rule{0.3em}{0ex}}\mathrm{meV}$ in constant-$Q$ (scattering vector) scan spectra, indicating spin-gap excitation. From results of these measurements, we have obtained that the strongest exchange interaction exists in a Cu-O-P-O-Cu path in spite of the existence of Cu-O-Cu paths and that the antiferromagnetic alternating chain model with two exchange interaction values of 80 and $14\phantom{\rule{0.3em}{0ex}}\mathrm{K}$ can explain the experimental results quantitatively. Our results are consistent with the prediction of Yahia et al. [Inorg. Chem. 45, 5501 (2006)].
Is Breakdown of the Blood-Brain Barrier Responsible for Lacunar Stroke, Leukoaraiosis, and Dementia? (2003)

Proof that blood-brain barrier failure is key to these conditions could provide a target for new treatments to reduce the effects of vascular disease on the brain and prevent cognitive decline and dementia.
ZnO Nanoparticles: A Promising Anticancer Agent (2016)

Nanoparticles, with their selective targeting capabilities and superior efficacy, are becoming increasingly important in modern cancer therapy and starting to overshadow traditional cancer therapies such as chemotherapy radiation and surgery. ZnO nanoparticles, with their unique properties such as biocompatibility, high selectivity, enhanced cytotoxicity and easy synthesis, may be a promising anticancer agent. Zinc, as one of the major trace elements of the human body and co-factor of more than 300 mammalian enzymes, plays an important role in maintaining crucial cellular processes including oxidative stress, DNA replication, DNA repair, cell cycle progression and apoptosis. Thus, it is evident that an alteration in zinc levels in cancer cells can cause a deleterious effect. Research has shown that low zinc concentration in cells leads to the initiation and progression of cancer and high zinc concentration shows toxic effects. Zinc-mediated protein activity disequilibrium and oxidative stress through reactive oxygen species (ROS) may be the probable mechanism of this cytotoxic effect. The selective localization of ZnO nanoparticles towards cancer cells due to enhanced permeability and retention (EPR) effect and electrostatic interaction and selective cytotoxicity due to increased ROS present in cancer cells show that ZnO nanoparticles can selectively target and kill cancer cells, making them a promising anticancer agent.
C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study (2002)

Accumulating evidence implicates inflammation as a potential pathway in the pathogenesis of type 2 diabetes. The objective of the present study was to assess the ability of C-reactive protein (CRP) to predict the development of diabetes in middle-aged men in the West of Scotland Coronary Prevention Study. Baseline plasma samples for CRP measurement were available for 5,245 men of whom 127 were classified as having a transition from normal glucose control to overt diabetes during the study, based on American Diabetes Association criteria. Baseline CRP was an important predictor of the development of diabetes in univariate analysis (hazard ratio [HR] for an increase of 1 SD = 1.55; 95% CI 1.32-1.82; P < 0.0001). In multivariate analysis, CRP remained a predictor of diabetes development (HR 1.30; 95% CI 1.07-1.58; P = 0.0075) independent of other clinically employed predictors, including baseline BMI and fasting triglyceride and glucose concentrations. Moreover, there was a graded increase in risk across CRP quintiles throughout the study, evident at even 1 year of follow-up. The highest quintile (CRP >4.18 mg/l) was associated with a greater than threefold risk of developing diabetes (HR 3.07; 95% CI 1.33-7.10) in a multivariate analysis at 5 years. Thus, CRP predicts the development of type 2 diabetes in middle-aged men independently of established risk factors. Because CRP, the most commonly used acute-phase protein in clinical practice, is very stable in serum, our observations have clinical potential in helping to better predict individuals destined to develop type 2 diabetes. They also add to the notion that low-grade inflammation is important in the pathogenesis of type 2 diabetes.
Techniques of Microprocessor Testing and SEU-Rate Prediction (1985)

Several different approaches have been used in the past to assess the vulnerability of microprocessors to SEU. In this paper we discuss the advantages and disadvantages of each of these test methods, and address the question of how the microprocessor test results can be used to estimate upset rate in space. Finally, as an application of the above techniques, we present the test results and predicted upset rates in synchronous orbit for a selected group of microprocessors.
The Effect of Blueberry Extracts and Quercetin on Capacitation Status of Stored Boar Sperm (2005)

Liquid cooled boar semen is highly susceptible to lipid peroxidation and capacitation in vitro during storage, which results in reduced fertility and litter sizes following artificial insemination (AI). Antioxidants can delay lipid peroxidation in vitro and therefore potentially extend the lifespan of stored semen. Lowbush blueberries (Vaccinium angustifolium Aiton) and their leaves contain high antioxidant capacity, making them potential candidates for preserving liquid cooled boar semen during storage. This study compared the reversible ability of blueberry extract, leaf extract, and the antioxidant quercetin to prevent capacitation of extended, cooled boar semen during storage for 1 week. The results indicated that blueberry leaf extract and quercetin were equally capable of delaying capacitation for 1 week and still allow capacitation to occur in vitro following incubation at 39°C. Blueberry extract also delayed capacitation but only during storage for 5 days; its effects were also reversible. Blueberry leaf extract and quercetin are potential supplements for storage of liquid cooled boar semen.
Monitoring and predicting charging behaviour for electric vehicles (2012)

In this paper the tracking and analytical infrastructure necessary to understand and manage the power demands of an electric vehicle fleet is considered. The data from a 230 day trial of 15 electric vehicles has been used to create a model day for the equivalent of 3000 vehicles in the North East of England road network. Basic analytical approaches are considered and possible future avenues are addressed. A general model for predicting vehicle charging is proposed. The comparative charging rates between morning and evening and the spatial distribution of the charging are all considered. It is found that evening charging is the most common period of charging but morning charging, due to its spatial density, poses the most risk for local power. In more general terms the use of individual vehicle tracking systems is found to be an ideal system for determining the current and future state of power consumption for electric vehicles. Having such infrastructure is important from both a local area management perspective and also as a tool to inform decision makers and politicians on the future needs for electric vehicles. As the numbers of such vehicles on the road increases, it will become more important to manage the charging infrastructure and the electricity distribution network.
Uso de plantas medicinais por indivíduos com hipertensão arterial sistêmica, diabetes mellitus ou dislipidemias (2019)

Objetivos: Conhecer quais plantas medicinais são mais utilizadas por indivíduos com diagnóstico de hipertensão arterial sistêmica, diabetes mellitus ou dislipidemias, atendidos em unidade de saúde no município de Passo Fundo, RS. Métodos: Estudo transversal prospectivo. Foram entrevistados indivíduos maiores de 18 anos, usuários de medicamentos por meio de ficha individual estruturada com perguntas abertas e fechadas. Resultados: Foram entrevistados 125 indivíduos. A média de idade dos entrevistados foi de 68 anos, a maioria mulheres (78,4%) e aposentados (65,6%), 76% relatam ter o ensino fundamental incompleto, 84,8% utilizam somente a rede pública para assistência a saúde, 62,4% relataram fazer uso de plantas medicinais com finalidade terapêutica, sendo que destes, 96,1% usavam na forma de chá; 86,67% relataram não ingerir medicamentos junto com o chá e 30,67% tinha o hábito de informar ao médico que faziam uso de plantas medicinais. A Marcela (Achyrocline satureioides) foi a planta citada como sendo a mais utilizada, 91,2% acreditavam que o uso de plantas medicinais não causa reações adversas, interage e/ou interfere na ação dos medicamentos utilizados concomitantemente a elas. Conclusões: A prática do uso de chás é comum entre a população para tratar problemas de saúde, mas o conhecimento sobre indicação, modo de preparo e utilização, na maioria dos casos não tem orientação dos profissionais de saúde.
A cost-effectiveness analysis of treatment options for patients with methotrexate-resistant rheumatoid arthritis (2000)

Our analysis indicates that if 15 mg/week MTX is cost-effective for achieving ACR 20 or ACR 70WR in MTX-naive RA over a 6-month period, then most likely so is triple therapy in MTX-resistant RA. Whether etanercept + MTX is cost-effective depends on whether $34,800/ACR 70WR (or $42,600/ACR 20) over a 6-month period is considered acceptable.
Identification of 5 novel genes methylated in breast and other epithelial cancers (2010)

The combination of the MIRA assay with CpG island arrays is a very useful technique for identifying epigenetically inactivated genes in cancer genomes and can provide molecular markers for early cancer diagnosis, prognosis and epigenetic therapy.
Transition metal chelates as accelerators for epoxy resin systems—studies with cobalt (III) acetylacetonate (1990)

Abstract Cobalt(III)acetylacetonate serves as an accelerator for anhydride curable epoxy resin system and the rate of curing is found to increase with enhanced concentrations of the metal chelate. There is also an appreciable reduction in the cure gel time. Kinetic studies based on thermal analytical techniques reveal that the overall curing process follows first order kinetics. Based on the kinetic results a cure schedule has been proposed. It is also observed that the electrical, mechanical, and thermal properties of the cured epoxy system are not altered by the presence of the metal chelate at the concentration studied.
Towards a Case-Mix Information System for the Emergency Department (1984)

The introduction of DRG-based payment for inpatient care will bring increased attention to the fiscal performance of each department in the hospital. The emergency department is an important cost and revenue center and also generates a large number of admissions. DRG's do not now extend to emergency care, but DRG payment for inpatient care may have indirect effects on the ED, creating incentives for cost-containment measures in the ED. Such measures will require a better understanding of patient mix and resource use in the ED. A case-mix information system for the ED is described which satisfied two goals: (1) the creation of a database linking diagnosis to resource use and time for the study of a case-mix classification system for the ED; (2) the generation of case-mix-oriented reports to allow the development and evaluation of measures to improve the cost-effectiveness of emergency department care.