gebhart/patrepeval huggingface dataset:
A System for Centralized ABAC Policy Administration and Local ABAC Policy Decision and Enforcement in Host Systems using Access Control Lists (2018)

We describe a method that centrally manages Attribute-Based Access Control (ABAC) policies and locally computes and enforces decisions regarding those policies for protection of resource repositories in host systems using their native Access Control List (ACL) mechanisms. The method is founded on the expression of an ABAC policy that conforms to the access control rules of an enterprise and leverages the ABAC policy expression by introducing representations of local host repositories into the ABAC policy expression as objects or object attributes. Repositories may be comprised of individual files, directories, or other resources that require protection. The method further maintains a correspondence between the ABAC representations and repositories in local host systems. The method also leverages an ability to conduct policy analytics in such a way as to formulate ACLs for those representations in accordance with the ABAC policy and create ACLs on repositories using the ACLs of their corresponding representations. As the ABAC policy configuration changes, the method updates the ACLs on affected representations and automatically updates corresponding ACLs on local repositories. Operationally, users attempt to access resources in local host systems, and the ABAC policy is enforced in those systems in terms of their native ACLs.
High‐resolution multistation peripheral MR angiography using undersampled projection reconstruction imaging (2004)

A novel protocol for three-station MR angiography (MRA) of the lower extremities is described. A time-resolved undersampled projection reconstruction (PR) acquisition was used to image the calf station during a first injection, and non-time-resolved PR acquisitions were used with the bolus-chase technique to image the abdomen and thigh stations during a second injection. The streak artifacts resulting from undersampling the PR data were reduced with the use of a spatial Fermi filter based on the sensitivity of each coil element in a peripheral vascular phased-array coil. This novel technique provided high spatial resolution and a broad range of coverage, and depicted the contrast dynamics in the most distal station of the lower extremities.
Cloning, Functional Expression, and Characterization of Recombinant Pig Liver Esterase (2001)

The N-terminal amino acid sequence of pig liver esterase (PLE) from a commercial sample was determined and shown to match closely to a published sequence encoding a proline-β-naphthylamidase from pig liver. Next, mRNA isolated from pig liver was transcribed into cDNA and primers deduced from the N-terminal sequence were used to clone the 1698 base pairs of PLE cDNA. Initial attempts to express the cDNA in Escherichia coli and Pichia pastoris with different expression vectors and secretion signal sequences failed. Only after deletion of the putative C-terminal sequence His-Ala-Glu-Leu, usually considered as an endoplasmic reticulum retention signal, could heterologous expression of PLE be readily achieved in the methylotrophic yeast P. pastoris. Recombinant PLE (rPLE) was secreted into the medium and exhibited a specific activity of approximately 600 U mg−1 and a Vmax/Km value of 139 μmol min−1 mM−1 with p-nitrophenyl acetate as a substrate. Activity staining of renatured sodium dodecylsulfate–polyacrylamide gels gave a single band with esterolytic activity for rPLE, whereas several bands are visible in crude commercial PLE preparations. This was confirmed by native gels, which also show that rPLE is active as a trimer. Biochemical characterization of the recombinant enzyme and comparison with properties of commercial PLE preparations as well as with published data confirmed that we expressed a single PLE isoenzyme which showed a high preference for proline-β-naphthylamide. This is a substrate specificity for the so-called γ subunit of PLE. The optimum pH value and temperature for the recombinant PLE were 8.0 and 60 °C, respectively. The determined molecular weight of the secreted enzyme was approximately 61–62 kDa, which closely matches the calculated value of 62.419 kDa. The active site residues are located at Ser203, His448, and Asp97, and the typical consensus sequence motif for hydrolases was found around the active site serine (Gly-Glu-Ser-Ala-Gly).
Improvement of Inter-Layer Motion Prediction in Scalable Video Coding (2007)

In this letter, we propose an enhanced method for interlayer motion prediction in scalable video coding (SVC). For inter-layer motion prediction, the use of refined motion data in the Fine Granular Scalability (FGS) layer is proposed instead of the conventional use of motion data in the base quality layer to reduce the inter-layer redundancy efficiently. Experimental results show that the proposed method enhances coding efficiency without increasing the computational complexity of the decoder.
A method of combining coherence-constrained sparse coding and dictionary learning for denoising (2017)

We have addressed the seismic data denoising problem, in which the noise is random and has an unknown spatiotemporally varying variance. In seismic data processing, random noise is often attenuated using transform-based methods. The success of these methods in denoising depends on the ability of the transform to efficiently describe the signal features in the data. Fixed transforms (e.g., wavelets, curvelets) do not adapt to the data and might fail to efficiently describe complex morphologies in the seismic data. Alternatively, dictionary learning methods adapt to the local morphology of the data and provide state-of-the-art denoising results. However, conventional denoising by dictionary learning requires a priori information on the noise variance, and it encounters difficulties when applied for denoising seismic data in which the noise variance is varying in space or time. We have developed a coherence-constrained dictionary learning (CDL) method for denoising that does not require any a priori information related to the signal or noise. To denoise a given window of a seismic section using CDL, overlapping small 2D patches are extracted and a dictionary of patch-sized signals is trained to learn the elementary features embedded in the seismic signal. For each patch, using the learned dictionary, a sparse optimization problem is solved, and a sparse approximation of the patch is computed to attenuate the random noise. Unlike conventional dictionary learning, the sparsity of the approximation is constrained based on coherence such that it does not need a priori noise variance or signal sparsity information and is still optimal to filter out Gaussian random noise. The denoising performance of the CDL method is validated using synthetic and field data examples, and it is compared with the K-SVD and FX-Decon denoising. We found that CDL gives better denoising results than K-SVD and FX-Decon for removing noise when the variance varies in space or time.
Biochemical characterization of antigen-specific glycosylation-inhibiting factor from antigen-specific suppressor T cells. II. The 55-kDa glycosylation-inhibiting factor peptide is a derivative of TCR α-chain and a subunit of antigen-specific glycosylation-inhibiting factor (1996)

We isolated a unique TCR alpha-chain derived from the OVA-specific Ts hybridoma, 231F1. The TR alpha-chain consists of V alpha 11.3, a unique J alpha and a complete sequence of C alpha region. Transfection of the TCR-alpha cDNA into a TCR-alpha-, TCR-beta+ T cell line, 175.2, resulted in the expression of TCR-alpha beta, and the transfectant contained a 35-kDa peptide having the TCR- alpha-specific antigenic determinant. However, the stable transfectant failed to release a peptide with the TCR-alpha determinant upon stimulation with anti-CD3. In contrast, overexpression of the cDNA in the 231 F1 cells markedly increased the formation of the 55-kDa peptide, which reacted with both anti-glycosylation-inhibiting factor (GIF) and the mAb H28-710. Definitive evidence for the relationship between the 55-kDa peptide and the TCR alpha-chain was obtained by transfection of the cDNA of the TCR alpha-chain with histidine tag into the 231F1 cells. The 55 kDa GIF peptide formed by stable transfectants of the TCR-alpha-tag cDNA bound to Ni+-nitrilotriacetic acid-agarose. Upon stimulation with anti-CD3, a stable transfectant of the TCR-alpha cDNA formed OVA-specific GIF which contained the 55-kDa GIF peptide, and bound not only to anti-TCR-alpha column but also to anti-TCR-beta column. The results indicate that the OVA-specific GIF consists of the TCR-alpha+ 55-kDa GIF and another peptide with TCR-beta determinant. It was found that the association of the TCR-beta+ peptide with the 55-kDa GIF is required for binding of the factor to OVA, but not essential for the formation and release of the latter peptide.
Wear-Factor Prediction Based on Data-Driven Inversion Technique for Casing Wear Estimation (2020)

Abstract Wear factor is an important parameter for estimating casing wear, yet the industry lacks a sufficient data-driven wear-factor prediction model based on previous data. Inversion technique is a data-driven method for evaluating model parameters for a setting wherein the input and output values for the physical model/equation are known. For this case, the physical equation to calculate wear volume has wear factor, side force, RPM, tool-joint diameter, and time for a particular operation (i.e., rotating on bottom, rotating off bottom, sliding, back reaming, etc.) as inputs. Except for wear factor, these values are either available or can be calculated using another physical model (wear-volume output is available from the drilling log). Wear factor is considered the model parameter and is estimated using the inversion technique method. The preceding analysis was performed using soft-string and stiff-string models for side-force calculations and by considering linear and nonlinear wear-factor models. An iterative approach was necessary for the nonlinear wear-factor model because of its complexity. Log data provide the remaining thickness of the casing, which was converted into wear volume using standard geometric calculations. A paper [1] was presented in OMC 2019 discussing a method for bridging the gap. A study was conducted in this paper for a real well based on the new method, and successful results were discussed. The current paper extends that study to another real well casing wear prediction with this novel approach. Some methods discussed are already included in the mentioned paper.
Vascular cell responses to a hybrid Transforming Growth Factor-Beta molecule (1991)

Functional biological assays were performed using a hybrid molecule of Transforming Growth Factor-Beta (TGF-5 beta) where nine amino acids near the cleavage site of TGF-beta 1 were substituted with nine amino acids located in the identical position of TGF-beta 2. Bovine aortic endothelial and smooth muscle cells as well as rat epididymal fat pad microvascular endothelia were studied in three distinct bioassays examining proliferation, migration and angiogenesis. The data suggested TGF-5 beta elicited results that do not differ significantly from the TGF-beta 1 isoform, while TGF-beta 2 expressed unique characteristics. We have also shown that these amino acid substitutions to TGF-beta 1 do not, in fact, alter the biological functions of the growth factor.
Synthesis and properties of hole-doped Li1−xBC (2003)

Stoichiometric LiBC has been synthesized using both arc melting and sealed tantalum ampoule methods. Hole-doped Li1−xBC (0&lt;x⩽0.37) compounds have been realized through vacuum deintercalation from LiBC. The hexagonal crystal lattice has remained largely intact, with only slight decreases in lattice parameters upon hole-doping. The samples are intrinsically diamagnetic and are semiconducting in the 2–300 K range studied. Increased hole-doping leads to a color darkening as well as a decrease in resistivity.
Bend distortion in large mode area fiber amplifiers (2008)

As ever larger mode area fibers are designed and incorporated into high-power amplifiers, bend-induced mode distortion becomes an important limitation. In any reasonable coiled-fiber arrangement, bend distortion can reduce mode area, gain interaction, and suppression of higher-order modes. These impacts are reviewed, along with design strategies with increased immunity to bend distortion.
Isolation and Characterization of the Novel Botulinum Neurotoxin A Subtype 6 (2018)

Botulinum neurotoxins (BoNTs), the most potent toxins known to humans and the causative agent of botulism, exert their effect by entering motor neurons and cleaving and inactivating SNARE proteins, which are essential for neurotransmitter release. BoNTs are proven, valuable pharmaceuticals used to treat more than 200 neuronal disorders. BoNTs comprise 7 serotypes and more than 40 isoforms (subtypes). BoNT/A1 is the only A-subtype used clinically due to its high potency and long duration of action. While other BoNT/A subtypes have been purified and described, only BoNT/A2 is being investigated as an alternative to BoNT/A1. Here we describe subtype BoNT/A6 with improved pharmacological properties compared to BoNT/A1. It was isolated from <i>Clostridium botulinum</i> CDC41370, which produces both BoNT/B2 and BoNT/A6. The gene encoding BoNT/B2 was genetically inactivated, and A6 was isolated to greater than 95% purity. A6 was highly potent in cultured primary rodent neuronal cultures and in human induced pluripotent stem cell-derived neurons, requiring 20-fold less toxin to cause 50% SNAP-25 cleavage than A1. Second, A6 entered hiPSCs faster and more efficiently than A1 and yet had a long duration of action similar to BoNT/A1. Third, BoNT/A6 had similar LD<sub>50</sub> as BoNT/A1 after intraperitoneal injection in mice; however, local intramuscular injection resulted in less systemic toxicity than BoNT/A1 and a higher (i.m.) LD<sub>50</sub>, indicating its potential as a safer pharmaceutical. These data suggest novel characteristics of BoNT/A6 and its potential as an improved pharmaceutical due to more efficient neuronal cell entry, greater ability to remain localized at the injection site, and a long duration.<b>IMPORTANCE</b> Botulinum neurotoxins (BoNTs) have proved to be an effective treatment for a large number of neuropathic conditions. BoNTs comprise a large family of zinc metalloproteases, but BoNT/A1 is used nearly exclusively for pharmaceutical purposes. The genetic inactivation of a second BoNT gene in the native strain enabled expression and isolation of a single BoNT/A6 from cultures. Its characterization indicated that BoNT/A subtype A6 has a long duration of action comparable to A1, while it enters neurons faster and more efficiently and remains more localized after intramuscular injection. These characteristics of BoNT/A6 are of interest for potential use of BoNT/A6 as a novel BoNT-based therapeutic that is effective and has a fast onset, an improved safety profile, and a long duration of action. Use of BoNT/A6 as a pharmaceutical also has the potential to reveal novel treatment motifs compared to currently used treatments.
The Delayed Leaf Senescence Mutants of Arabidopsis, ore1, ore3, and ore9 are Tolerant to Oxidative Stress (2004)

Reactive oxygen species play a critical role in mediating the oxidative damage that causes senescence in a variety of aerobic organisms, from yeast to mammals. Genetic studies of these organisms have revealed that extended longevity is frequently associated with an increased resistance to stress. However, the relationship between life span and oxidative stress tolerance in plants is poorly understood. We have investigated the responses to oxidative stress in the delayed leaf senescence mutants of Arabidopsis thaliana, ore1, ore3, and ore9. The detached leaves of these mutants exhibit increased tolerance to various types of oxidative stress. The ore1, ore3, and ore9 mutants were also more tolerant to oxidative stress at the level of the whole plant, as determined by measuring physiological and molecular changes associated with oxidative stress. However, the activities of antioxidant enzymes were similar or lower in the mutants, as compared to wild type. These results suggest that the increased resistance to oxidative stress in the ore1, ore3, and ore9 mutants is not due to enhanced activities of these antioxidant enzymes. Taken together, our findings provide genetic evidence that oxidative stress tolerance is linked to control of leaf longevity in plants.
Multiprocessor bus control (1989)

This patent describes, in a multiprocessor computer which includes a bus and two or more processors coupled to the bus, where first and second processors may exchange a packet of data words during a packet transfer cycle, a bus protocol system for controlling access to the bus by the processors and for establishing a sender/receiver processor pair.
The Discharge Mechanism for Solid-State Lithium-Sulfur Batteries (2019)

Abstract The electrochemical discharge mechanism is reported for all-solid lithium sulfur batteries. Upon milling with carbon fibers, the solid electrolyte used within the cathode composite becomes electrochemically active. Analysis with Raman spectroscopy and XPS revealed the importance of bridging S-S bond formation and breaking in lithium polysulfidophosphates during electrochemical lithiation of the active solid electrolyte. Remarkably, when sulfur is introduced as an active material in the cathode composite, lithium polysulfides are formed as an intermediate product before full lithiation into lithium sulfide. The synthesis of materials based on bridging S-S bonds is an important avenue to the design of new cathodes for allsolid batteries.
Polymer-assisted deposition of metal-oxide films (2008)

In the last several years, metal-oxides have become the basis for many revolutionary electronic devices because they exhibit a wide range of electronic properties that conventional metallic elements and covalent semiconductors do not possess. Metal-oxide films can be grown by physical vapor deposition, chemical vapor deposition, and chemical solution deposition techniques. One of the challenges in solution-based processes of complex functional metal-oxide films has been to produce high quality films and at the same time to control the stoichiometry. In this talk, we describe a new chemical solution method called polymer-assisted deposition (PAD) to grow epitaxial complex metal-oxides such as ferroelectric Ba1-xSrxTiO3, Pb0.40Sr0.60TiO3, and BaZr0.27Ti0.73O3 films. We use a new strategy to control the distribution of metals in solution at a molecular level and a mixture of metal precursor and soluble polymer to form a solution with desired viscosity. By actively binding the metal, the polymer serves to encapsulate the metal to prevent chemical reaction while maintaining an even distribution of the metal in solution.Ü This ensures a homogeneous metal distribution and prevents unwanted reactivity that can lead to the formation of undesired phases. The successful growth of epitaxial ferroelectric films with desired properties by PAD suggests that PAD is a feasible alternative approach to the growth of high quality ferroelectric materials.
Ultrahigh power factor and thermoelectric performance in hole-doped single-crystal SnSe (2015)

Thermoelectric technology, harvesting electric power directly from heat, is a promising environmentally friendly means of energy savings and power generation. The thermoelectric efficiency is determined by the device dimensionless figure of merit ZT(dev), and optimizing this efficiency requires maximizing ZT values over a broad temperature range. Here, we report a record high ZT(dev) ∼1.34, with ZT ranging from 0.7 to 2.0 at 300 to 773 kelvin, realized in hole-doped tin selenide (SnSe) crystals. The exceptional performance arises from the ultrahigh power factor, which comes from a high electrical conductivity and a strongly enhanced Seebeck coefficient enabled by the contribution of multiple electronic valence bands present in SnSe. SnSe is a robust thermoelectric candidate for energy conversion applications in the low and moderate temperature range.
Rationally Evolving MCP-1/CCL2 into a Decoy Protein with Potent Anti-inflammatory Activity in Vivo (2010)

Leukocyte recruitment from the blood into injured tissues during inflammatory diseases is the result of sequential events involving chemokines binding to their GPC receptors as well as to their glycosaminoglycan (GAG) co-receptors. The induction and the crucial role of MCP-1/CCL2 in the course of diseases that feature monocyte-rich infiltrates have been validated in many animal models, and several MCP-1/CCL2 as well as CCR2 antagonists have since been generated. However, despite some of them being shown to be efficacious in a number of animal models, many failed in clinical trials, and therapeutically interfering with the activity of this chemokine is not yet possible. We have therefore generated novel MCP-1/CCL2 mutants with increased GAG binding affinity and knocked out CCR2 activity, which were designed to interrupt the MCP-1/CCL2-related signaling cascade. We provide evidence that our lead mutant MCP-1(Y13A/S21K/Q23R) exhibits a 4-fold higher affinity toward the natural MCP-1 GAG ligand heparan sulfate and that it shows a complete deficiency in activating CCR2 on THP-1 cells. Furthermore, a significantly longer residual time on GAG ligands was observed by surface plasmon resonance. Finally, we were able to show that MCP-1(Y13A/S21K/Q23R) had a mild ameliorating effect on experimental autoimmune uveitis and that a marginal effect on oral tolerance in the group co-fed with Met-MCP-1(Y13A/S21K/Q23R) plus immunogenic peptide PDSAg was observed. These results suggest that disrupting wild type chemokine-GAG interactions by a chemokine-based antagonist can result in anti-inflammatory activity that could have potential therapeutic implications.
Non-Linear Shape Preserving Electron-Beams (2014)

We show that shaping the initial wavefunction of a multi-electron system can lead to electron beams displaying shape-preserving propagation in spite of the inherent repulsion among electrons. This idea suggests applications in microscopy and lithography.
Multi-stream video conferencing over a peer-to-peer network (2010)

Video conferencing is becoming an increasingly desirable alternative to face-to-face meetings. Many companies and organizations have multiple locations, and their employees' communication options are typically limited to audio-only conference calls. These are often ineffective because of the limited level of interaction between the participants. Video conferencing is seen as a promising alternative to increase efficiency and reduce carbon emissions by mitigating the need for travel. However, current video conferencing solutions are either too expensive, require dedicated equipment and infrastructure, or are too cumbersome to implement on an individual location basis for widespread use. Low cost solutions usually provide neither the desired level of interaction nor the consistent quality needed for corporate communications. In this paper, we propose a novel hybrid video conferencing architecture that incorporates peer-to-peer communication functions for media distribution. In addition, new concepts, such as novel video cameras, cordless camera adaptors, a two-sided display, and a device that provides bidirectional remote presence are presented to enhance the experience for the remote participants. The proposed solution aims to significantly improve collaboration across sites, thus enhancing remote workplace effectiveness through low cost video conferencing, reducing the need for travel, and serving as an important enabler for eco-sustainability.