gebhart/patrepeval huggingface dataset:
Measuring Patient Mobility in the ICU Using a Novel Noninvasive Sensor (2017)

Noninvasive mobility sensor is a novel and feasible method for automating evaluation of ICU patient mobility.
Parameterization of tubular surfaces on the cylinder (2005)

In this paper we develop a method to parameterize tubular surfaces onto the cylinder. The cylinder can be seen\nas the natural parameterization domain for tubular surfaces since they share the same topology. Most present\nalgorithms are designed to parameterize disc-like surfaces onto the plane. Surfaces with a different topology are cut\ninto disc-like patches and the patches are parameterized separately. This introduces discontinuities and constrains\nthe parameterization. Also the semantics of the surface are lost. We avoid this by parameterizing tubular surfaces\non, their natural domain, the cylinder. Since the cylinder is locally isometric to the plane we can do calculations\non the cylinder without loosing efficiency. For speeding up the calculation we use a progressive parameterization\ntechnique, as suggested in recent literature. Together, this results in a robust, efficient, continuous, and semantics\npreserving parameterization method for arbitrary tubular surfaces.
Level based on moire effect with ambient light (1984)

A novel level which can replace high accuracy bubble levels is described. It is based on the moire effect but does not require a light source or detection equipment. The level has a high dynamic range compared to conventional instruments.
<i>CXCR4</i> mutation subtypes impact response and survival outcomes in patients with Waldenström macroglobulinaemia treated with ibrutinib (2019)

Ibrutinib is associated with response rate of 90% and median progression-free survival (PFS) in excess of 5 years in Waldenström macroglobulinaemia (WM) patients. CXCR4 mutations are detected in 30-40% of patients with WM and associate with lower rates of response and shorter PFS to ibrutinib therapy. Both frameshift (CXCR4<sup>FS</sup> ) and nonsense (CXCR4<sup>NS</sup> ) CXCR4 mutations have been described. The impact of these mutations on outcomes to ibrutinib have not been evaluated in WM patients. We studied consecutive patients with a diagnosis of WM, on ibrutinib therapy, for the presence of CXCR4<sup>FS</sup> and CXCR4<sup>NS</sup> mutations and evaluated the differences in response and PFS between groups. Of 180 patients, 68 patients (38%) had CXCR4 mutations; 49 (27%) had CXCR4<sup>NS</sup> and 19 (11%) had CXCR4<sup>FS</sup> mutations. In multivariate models, patients with CXCR4<sup>NS</sup> had lower odds of major response (Odds ratio 0·25, 95% confidence interval [CI] 0·12-0·53; P < 0·001) and worse PFS (Hazard ratio 4·02, 95% CI 1·95-8·26; P < 0·001) than patients without CXCR4 mutations. CXCR4<sup>FS</sup> was not associated with worse major response or PFS rates than patients without CXCR4 mutations. Our results suggest different response and PFS rates to ibrutinib for WM patients with CXCR4<sup>NS</sup> and CXCR4<sup>FS</sup> , and advocate in favour of CXCR4 mutational testing as well as CXCR4-directed therapy.
A novel, thermally-stable InGaAs/GaAs structure for 1.3 μm IMSM photodetectors (1990)

A novel super-lattice enhanced InGaAs/GaAs interdigitated-metal-semiconductor-metal (IMSM) photodetector structure operating at 1.3 μ m has been realized. The structure is stable after high temperature rapid thermal annealing, thus offering the potential monolithic integration with ion implanted GaAs MESFETs. The photodetectors have low dark current, an internal quantum efficiency of 86%, and a bandwidth of 14 GHz.
Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors (2018)

Mutant isocitrate dehydrogenase 1 (IDH1) is an attractive therapeutic target for the treatment of various cancers such as AML, glioma, and glioblastoma. We have evaluated 3-pyrimidin-4-yl-oxazolidin-2-ones as mutant IDH1 inhibitors that bind to an allosteric, induced pocket of IDH1<sup>R132H</sup>. This Letter describes SAR exploration focused on improving both the <i>in vitro</i> and <i>in vivo</i> metabolic stability of the compounds, leading to the identification of <b>19</b> as a potent and selective mutant IDH1 inhibitor that has demonstrated brain penetration and excellent oral bioavailability in rodents. In a preclinical patient-derived IDH1 mutant xenograft tumor model study, <b>19</b> efficiently inhibited the production of the biomarker 2-HG.
Free-space photonic switching architectures based on extended generalized shuffle networks (1992)

A new class of networks that is well suited for free-space photonic switching applications is described. These networks are known as extended generalized shuffle networks. It is shown that these networks can provide low blocking probabilities while requiring low hardware costs. In fact, if sufficient hardware is added to these networks, they become strictly nonblocking networks (with blocking probabilities equal to zero). The hardware cost of an extended generalized shuffle network can be modified to yield any desired blocking probability, so cost-effective designs are possible. In addition, it is shown that these networks are extremely fault tolerant, and they can also be designed to have high system availabilities. Because the networks can use various types of interconnections to connect the nodes and because the nodes can have various types of functionality, these networks also provide high degrees of flexibility that can be used to optimize a free-space photonic design. The design of extended generalized shuffle networks based on a particular node type that is easy to implement with symmetric self-electro-opticeffect devices is studied.
Getting some perspective (1999)

Process descriptions are used in workflow and related systems to describe the flow of work and organisational responsibility in business processes, and to aid in coordination. However, the division of a working process into a sequence of steps provides only a partial view of the work involved. In many cases, the performance of individual tasks in a larger process may depend on interpretations and understandings of how other aspects of the work were conducted.
Rapid Detection of Methicillin-Resistant <i>Staphylococcus aureus</i> Directly from Sterile or Nonsterile Clinical Samples by a New Molecular Assay (2003)

A rapid procedure was developed for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) directly from sterile sites or mixed flora samples (e.g., nose or inguinal swabs). After a rapid conditioning of samples, the method consists of two main steps: (i) immunomagnetic enrichment in S. aureus and (ii) amplification-detection profile on DNA extracts using multiplex quantitative PCR (5'-exonuclease qPCR, TaqMan). The triplex qPCR assay measures simultaneously the following targets: (i) mecA gene, conferring methicillin resistance, common to both S. aureus and Staphylococcus epidermidis; (ii) femA gene from S. aureus; and (iii) femA gene from S. epidermidis. This quantitative approach allows discrimination of the origin of the measured mecA signal. qPCR data were calibrated using two reference strains (MRSA and methicillin-resistant S. epidermidis) processed in parallel to clinical samples. This 96-well format assay allowed analysis of 30 swab samples per run and detection of the presence of MRSA with exquisite sensitivity compared to optimal culture-based techniques. The complete protocol may provide results in less than 6 h (while standard procedure needs 2 to 3 days), thus allowing prompt and cost-effective implementation of contact precautions.
Suppression of BRAF/MEK/MAP Kinase Pathway Restores Expression of Iodide-Metabolizing Genes in Thyroid Cells Expressing the V600E BRAF Mutant (2007)

We showed the restorability of expression of thyroid iodide-metabolizing genes silenced by V600E BRAF, and linked this process to gene methylation in PTC cells. The results provide clinical implications that therapeutic targeting at the BRAF/MEK/MAP kinase pathway may be a good approach in restoring thyroid gene expression for effective radioiodine therapy for BRAF mutation-harboring PTC.
Abstract #LB-200: A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy (2009)

Human ABCG2, a member of the ATP-binding cassette transporter superfamily, plays a key role in multidrug resistance in cancer chemotherapy and represents a promising target for chemosensitization. In this report, we show finding of a novel specific ABCG2 inhibitor, PZ-39, and its mechanism of action. Unlike any previously known ABC transporter inhibitors, PZ-39 has two modes of actions by inhibiting ABCG2 activity, an acute effect, and by causing ABCG2 conformational change which accelerates its lysosome-dependent degradation, a chronic effect. PZ-39 has no effect on ABCB1 and ABCC1-mediated drug efflux, resistance, and their expression, indicating that it is specific to ABCG2. The structural properties of PZ-39 derivatives have been identified using a structure-activity relationship analysis. PZ-39 is potentially a valuable probe and lead compound for developing therapeutics targeting ABCG2-mediated multidrug resistance in cancer chemotherapy. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr LB-200.
Nonlinearity Suppressed by Applying Phase Adjuster in Thermoacoustic System (2008)

A phase adjuster (PA) has been proposed to improve the energy conversion efficiency of a loop‐tube‐type thermoacoustic system. A PA is a device for increasing the particle velocity of the sound by narrowing part of the loop tube. In this experiment, we present a discussion of the efficiency of heat‐to‐sound energy conversion in a loop‐tube‐type thermoacoustic prime mover, emphasizing the nonlinearity suppressed by PA. It is found that the sound intensity with PA is greater than that without PA. This means that the efficiency of heat‐to‐sound energy conversion is improved with PA. Results obtained in this experiment reveal that the nonlinearity of the self‐sustained sound generated in the loop tube is suppressed by placing PA. It is known that the acoustic streaming induced by the nonlinear effect decreases the energy conversion efficiency. It is considered that the suppression of nonlinearity results in the suppression of acoustic streaming, and consequently the energy conversion efficiency is improved.
Microfabricated fluidic devices: new approaches to chemical measurements (2001)

Microfabricated fluidic devices (microchips) may allow a paradigm shift that greatly enhances the ability to acquire chemical and biochemical information similar to the ways in which the transistor and integrated circuit have influenced access to electronically coded information[l,2]. Our work on moving conventional bench-top liquid phase assays to microfabricated fluidic devices will be described. The implementation of chemical separation strategies on microfabricated platforms is a key element of this so-called lab-on-a-chip technology. Many separations concepts have now been demonstrated on microfabricated structures, including capillary electrophoresis, capillary gel electrophoresis, micellar electrokinetic capillary chromatography, open channel electrochromatography, solvent programmed micellar electrokinetic capillary chromatography[3] and open channel electrochromatography[4], free flow electrophoresis, and isoelectric focusing. In most cases, these separation techniques were transferred from conventional approaches to microstructures with increased levels of performance. Moreover, microfabricated fluidic structures provide the added advantage of allowing monolithic integration of chemical processing functional elements with essentially zero dead volume interconnects. Chemical processing elements that have been integrated with chemical separations on microchips include pre-and post-separation derivitization, enzymatic digestion[5], polymerase chain reaction amplification, antigenic reactions[6], and preconcentration by stacking, solid phase extraction, and electrokinetic accumulation on a microfabricated membrane[7]. Fundamental advantages and disadvantages of microfabricated fluidic devices will be discussed.
Integrating ICP and LRA solvers for deciding nonlinear real arithmetic problems (2010)

We propose a novel integration of interval constraint propagation (ICP) with SMT solvers for linear real arithmetic (LRA) to decide nonlinear real arithmetic problems. We use ICP to search for interval solutions of the nonlinear constraints, and use the LRA solver to either validate the solutions or provide constraints to incrementally refine the search space for ICP. This serves the goal of separating the linear and nonlinear solving stages, and we show that the proposed methods preserve the correctness guarantees of ICP. Experimental results show that such separation is useful for enhancing efficiency.
Performance of a Computerized Protocol for Trauma Shock Resuscitation (2009)

A computerized protocol to guide decision making for trauma shock resuscitation in a Level 1 trauma center surgical ICU was developed and used as standard of care. During 2 years ending at August 2006, 94% of computer-generated instructions for specific interventions or measurements of hemodynamic performance were accepted by bedside clinicians, indicating appropriate, useful design and reliance on the computerized protocol system.
Antibody‐mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities (2017)

JMJD6 is known to localize in the nucleus, exerting histone arginine demethylase and lysyl hydroxylase activities. A novel localization of JMJD6 in the extracellular matrix, resulting from its secretion as a soluble protein, was unveiled by a new anti-JMJD6 mAb called P4E11, which was developed to identify new targets in the stroma. Recombinant JMJD6 binds with collagen type I (Coll-I), and distinct JMJD6 peptides interfere with collagen fibrillogenesis, collagen-fibronectin interaction, and adhesion of human tumor cells to the collagen substrate. P4E11 and collagen binding to JMJD6 are mutually exclusive because the amino acid sequences of JMJD6 necessary for the interaction with Coll-I are part of the conformational epitope recognized by P4E11. In mice injected with mouse 4T1 breast carcinoma cells, treatment with P4E11 reduced fibrosis at the primary tumor and prevented lung metastases. Reduction of fibrosis has also been documented in human breast and ovarian tumors (MDA-MB-231 and IGROV1, respectively) xenotransplanted into immunodeficient mice treated with P4E11. In summary, this study uncovers a new localization and function for JMJD6 that is most likely independent from its canonical enzymatic activities, and demonstrates that JMJD6 can functionally interact with Coll-I. P4E11 mAb, inhibiting JMJD6/Coll-I interaction, represents a new opportunity to target fibrotic and tumor diseases.-Miotti, S., Gulino, A., Ferri, R., Parenza, M., Chronowska, A., Lecis, D., Sangaletti, S., Tagliabue, E., Tripodo, C., Colombo, M. P. Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities.
Drug-eluting stent technologies for vascular regeneration (2007)

Abstract Currently, first generation drug-eluting stents are widely used in clinical practice to revascularize stenotic arterial vessel segments, and to prevent in-stent restenosis and other shortcomings of conventional bare metal stents. However, clinically relevant risks associated with current drug-eluting stents, such as delayed healing, late thrombosis and hypersensitivity, as well as the permanent nature of the stents represent challenges for further development in this field. This paper reviews current drug-eluting stent technology, and describes recent advances towards a second generation of drug-eluting stents. Particular emphasis is put on the development of stents from bioabsorbable materials as a temporary alternative to permanent stent implants.
Dose measurements in photodynamic therapy of cancer (1987)

A theory and method for prediction and measurement of the effective absorbed dose in photodynamic therapy of cancer is presented. The method depends on measuring the concentration of the photosensitizer (such as dihematorporphyrin ether), the flux density of the light, and the relative photodynamic effectiveness. Previous, less exact methods relied on specifying the drug dosage and delay after injection and or the irradiance at the surface or power from an interstitial fiber. The new formulation should permit closer control of the effective absorbed dose and better clinical results with photodynamic therapy.
Gel Electrode Evaluation of Fatigue Performance of Aluminum Components (1984)

The gel electrode produces clearly visible images of fatigue cracks in aluminum alloys. The only preparation required is the formation of a thin (1.4 x 10/sup -5/ mm) anodic oxide film on the surface. After fatigue cycling a gel electrolyte is pressed against the surface and a voltage pulse applied. As the current flows preferentially to the fatigue cracks an image is formed in the surface of the gel. The technique is extremely sensitive -- fatigue cracks as short as 10/sup -2/ mm have been detected -- and provides a more rapid and more complete evaluation of the fatigue performance of automotive components than has been possible hitherto. This initial application at the Chevrolet Engineering Center demonstrates the following advantages. (i) Primary fatigue sites are detected very early in a test so that designs can be rapidly evaluated and compared. (ii) Sites of secondary fatigue damage are also detected so that several design changes can be incorporated simultaneously.
Generation of novel monoclonal antibodies for the enrichment and characterization of human corneal endothelial cells (hCENC) necessary for the treatment of corneal endothelial blindness (2014)

Corneal transplantation is the primary treatment option to restore vision for patients with corneal endothelial blindness. Although the success rate of treatment is high, limited availability of transplant grade corneas is a major obstacle. Tissue-engineered corneal endothelial grafts constructed using cultivated human corneal endothelial cells (hCENC) isolated from cadaveric corneas may serve as a potential graft source. Currently, tools for the characterization of cultured hCENC and enrichment of hCENC from potential contaminating cells such as stromal fibroblasts are lacking. In this study, we describe the generation and characterization of novel cell surface monoclonal antibodies (mAbs) specific for hCENC. These mAbs could be used for enrichment and characterization of hCENC. Out of a total of 389 hybridomas, TAG-1A3 and TAG-2A12 were found to be specific to the corneal endothelial monolayer by immunostaining of frozen tissue sections. Both mAbs were able to clearly identify hCENC with good 'cobblestone-like' morphology from multiple donors. The antigen targets for TAG-1A3 and TAG-2A12 were found to be CD166/ALCAM and Peroxiredoxin-6 (Prdx-6), respectively, both of which have not been previously described as markers of hCENC. Additionally, unlike other Prdx-6 mAbs, TAG-2A12 was found to specifically bind cell surface Prdx-6, which was only expressed on hCENC and not on other cell types screened such as human corneal stromal fibroblasts (hCSF) and human pluripotent stem cells (hPSC). From our studies, we conclude that TAG-1A3 and TAG-2A12 are promising tools to quantitatively assess hCENC quality. It is also noteworthy that the binding specificity of TAG-2A12 could be used for the enrichment of hCENC from cell mixtures of hCSF and hPSC.
Straintronic magneto-tunneling-junction based ternary content addressable memory (2016)

Straintronic magneto-tunneling junction (s-MTJ) switches, whose resistances are controlled with voltage-generated strain in the magnetostrictive free layer of the MTJ, are extremely energy-efficient switches that would dissipate a few aJ of energy during switching. Unfortunately, they are also relatively error-prone and have low resistance on/off ratio. This suggests that as computing elements, they are best suited for non-Boolean architectures. Here, we propose and analyze a ternary content addressable memory implemented with s-MTJs and some transistors. It overcomes challenges encountered by traditional all-transistor implementations, resulting in exceptionally high cell density.
A Comparative Study of Color and Contrast Enhancement for Still Images and Consumer Video Applications (2008)

The goal of color and contrast enhancement in general is to provide a more appealing image or video by adjusting the amount of saturation and lightness to achieve more vivid or realistic colors and to increase the visibility of details that may be obscured by deficient global and local lightness. We implemented and compared the performance of various color and contrast enhancement algorithms using image difference maps in all three dimensions of lightness, chroma and hue, derived from IPT, a uniform, perceptual color space. The comparative analysis includes four published methods, two proprietary algorithms commonly used in consumer video applications and a new proposed approach developed as part of our research. Functionalities of these algorithms are evaluated with regard to the working requirements for an algorithm to be suitable for a typical video processing chain in consumer systems. We also report the results obtained from two psychophysical experiments involving the proprietary and proposed algorithms. Several still images and videos are used in the Method of Paired Comparison experiments to compare overall image/picture quality of various algorithm outputs. Results show a consistently satisfactory performance of the new algorithm, with opportunities for further improvement.