gebhart/patrepeval huggingface dataset:
“Antimyeloangiogenic” Therapy for Cancer by Inhibiting PlGF (2009)

Inhibition of tumor angiogenesis emerged as valuable strategy to treat cancer and has revolutionized the face of clinical oncology by prolonging the life of numerous cancer patients. However, the duration of this response is rather short and tumors rapidly evade treatment, leaving antiangiogenic treatment thus far unable to cure cancer. Hence, novel targets are needed to diversify antiangiogenic treatments and to overcome resistance. Recent data support the concept that tumor infiltration by bone marrow-derived myeloid cells confers resistance to current antiangiogenic drugs targeting primarily vascular endothelial growth factor (VEGF). In this review, we will summarize (pre)clinical data on the role of PlGF and its receptor VEGFR-1 in promoting angiogenesis and inflammation, and the "antimyeloangiogenic" activity of an antibody against PlGF (alphaPlGF), which may help to overcome resistance against VEGF(R)Is. Because of these promising results, a humanized alphaPlGF antibody (TB403) is currently evaluated in different phase I clinical trials in cancer patients.
Efficient stochastic list successive cancellation decoder for polar codes (2015)

Representing continuous values by streams of random binary bits, stochastic decoding has shown advantages in both hardware efficiency and fault tolerance, therefore has been widely adopted by iterative decoding of error correction codes such as low-density parity-check (LDPC) codes and so on. Recently, polar codes, the first codes that can provably achieve the capacity of symmetric binary-input discrete memoryless channels (B-DMCs), have drawn a lot of attentions from both academia and industry. Although, polar codes with list successive cancellation (SC) decoding can outperform several best-known LDPC codes even within high error-rate regions, the linearly increasing hardware complexity makes its efficient implementation difficult. To this end, the stochastic list SC polar decoding algorithm is proposed in this paper to provide a good tradeoff between performance and complexity. In order to increase the decoding performance of stochastic list SC polar decoder, doubling probability approach is presented. The corresponding hardware architecture is also given. The approximate doubling approach is employed to facilitate the efficient implementation. Implementation results have shown that the proposed stochastic list SC polar decoder can achieve a good trade-off between performance and complexity.
Crida de l'aplec de la Rosa 2011. Presentació de Muriel Casals i Couturier (2012)

Llengua, cultura i pais. Certament als de casa i amics mes propers no els he fet perdre, encara, el factor sorpresa. Que dius que has de fer ara? Es que a Tona aquest cap de setmana es festa grossa: celebrem els 69 anys de l’Aplec de la Rosa a Lurdes i al Castell i haig de presentar la cridanera.
Studying Temporal Correlation Noise Modeling for Pixel Based Wyner-Ziv Video Coding (2006)

Wyner-Ziv (WZ) video coding-a particular case of distributed video coding (DVC)-is a new video coding paradigm based on two major information theory results: the Slepian-Wolf and Wyner-Ziv theorems. Recently, practical WZ video coding solutions were proposed with promising results. Most of the solutions available in the literature, model the correlation noise between the original frame and the so-called side information by a given distribution whose relevant parameters are estimated in an offline process, at the encoder. In this paper, three algorithms are proposed towards a more realistic WZ coding approach by performing online estimation of the error distribution at the decoder. Both algorithms explore temporal correlation between frames however with different levels of granularity: frame, block and pixel levels; better rate-distortion (RD) performance is achieved for lower granularity (pixel) level.
A nickel catalyst for the arylation and vinylation of lithium ester enolates (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA nickel catalyst for the arylation and vinylation of lithium ester enolatesAlan A. Millard and Michael W. RathkeCite this: J. Am. Chem. Soc. 1977, 99, 14, 4833–4835Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://pubs.acs.org/doi/10.1021/ja00456a055https://doi.org/10.1021/ja00456a055research-articleACS PublicationsRequest reuse permissionsArticle Views1192Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reviews of Books (1989)

Reviews of Books Get access Deutsche Gesellschaftsgeschichte. Vol. I: Vom Feudalismus des Alten Reicbes bis zur Defensiven Modernisierung der Reformära, 1700–1815. Vol. II: Von der Reformära bis zur industriellen und politischen ‘Deutschen Doppelrevolution’, 1815–1845/49. By HANS-ULRICH WEHLER. (Munich: C. H. Beck, 1987; pp. x + 676, xi + 914. DM 88 each). MICHAEL JOHN MICHAEL JOHN Magdalen CollegeOxford Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume CIV, Issue CCCCXII, July 1989, Pages 701–704, https://doi.org/10.1093/ehr/CIV.CCCCXII.701 Published: 01 July 1989
Copolymerization of N-vinylpyrrolidone with 3-methacryloyloxytetrahydrothiophene 1,1′-dioxide (2006)

Radical copolymerization of N-vinylpyrrolidone with 3-methacryloyloxytetrahydrothiophene 1,1′-dioxide in the bulk and in dimethyl sulfoxide in the range of low conversions was studied. The kinetic features of copolymerization were examined. The relative activities of monomers and the structure and some characteristics of the copolymers were determined.
Real-Time Operating Systems and Programming Languages for Embedded Systems (2012)

errors could be more costly on a time critical application project than on a non real time one given that not being time compliant may cause a complete re-engineering of the system. The introduction of non-functional requirements such as temporal constraints makes the design and implementation of these systems increasingly costly and delays the introduction of the final product into the market. Not surprisingly, development methodologies for real-time frameworks have become a widespread research topic in recent years.
Beyond knockout rats (2011)

The ability to "knockout" specific genes in mice via embryonic stem (ES) cell-based gene-targeting technology has significantly enriched our understanding of gene function in normal and disease phenotypes. Improvements on this original strategy have been developed to enable the manipulation of genomes in a more sophisticated fashion with unprecedented precision. The rat is the model of choice in many areas of scientific investigation despite the lack of rat genetic toolboxes. Most Recent advances of zinc finger nucleases (ZFNs) and rat ES cells are diminishing the gap between rat and mouse with respect to reverse genetic approaches. Importantly, the establishment of rat ES cell-based gene targeting technology, in combination with the unique advantages of using rats, provides new, exciting opportunities to create animal models that mimic human diseases more faithfully. We hereby report our recent results concerning finer genetic modifications in the rat, and propose their potential applications in addressing biological questions.
Multiutility Sophorolipids as Nanoparticle Capping Agents:  Synthesis of Stable and Water Dispersible Co Nanoparticles (2007)

Sophorolipids are a class of glycolipids that can be obtained from fatty acids by simply treating them with yeast cells (Candida bombicola, ATCC 22214) and glucose. In this letter, we demonstrate the application of sophorolipids obtained from oleic acid as a capping agent for Co nanoparticles. Upon capping the nanoparticle surface, the sugar moiety of these sophorolipids is exposed to the solvent environment, making the nanoparticles stable and water-redispersible.
Chlamydiae as Pathogens: New Species and New Issues (1996)

The recognition of genital chlamydial infection as an important public health problem was made first by the recognition of its role in acute clinical syndromes, as well as in serious reproductive and ocular complications, and secondly by our awareness of its prevalence when diagnostic tests became widely accessible. The recent availability of effective single dose oral antimicrobial therapy and sensitive molecular amplification tests that allow the use of noninvasive specimens for diagnosis and screening is expected to have a major impact in reducing the prevalence of disease in the next decade. Clinical manifestations associated with Chlamydia pneumoniae infection continue to emerge beyond respiratory illness. In particular, its association with atherosclerosis deserves further investigation. Chlamydia pecorum, a pathogen of ruminants, was recently recognized as a new species. The continued application of molecular techniques will likely elucidate an expanding role for chlamydiae in human and animal diseases, delineate the phylogenetic relationships among chlamydial species and within the eubacteria domain, and provide tools for detection and control of chlamydial infections.
WikiCREM: A Large Unsupervised Corpus for Coreference Resolution (2019)

Vid Kocijan, Oana-Maria Camburu, Ana-Maria Cretu, Yordan Yordanov, Phil Blunsom, Thomas Lukasiewicz. Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and the 9th International Joint Conference on Natural Language Processing (EMNLP-IJCNLP). 2019.
Latency and Initiation of the Human Vestibuloocular Reflex to Pulsed Galvanic Stimulation (2006)

Cathodal galvanic currents activate primary vestibular afferents, whereas anodal currents inhibit them. Pulsed galvanic vestibular stimulation (GVS) was used to determine the latency and initiation of the human vestibuloocular reflex. Three-dimensional galvanic vestibuloocular reflex (g-VOR) was recorded with binocular dual-search coils in response to a bilateral bipolar 100-ms rectangular pulse of current at 0.9 (near-threshold), 2.5, 5.0, 7.5, and 10.0 mA in 11 normal subjects. The g-VOR consisted of three components: conjugate torsional eye rotation away from cathode toward anode; vertical divergence (skew deviation) with hypertropia of the eye on the cathodal and hypotropia of the eye on the anodal sides; and conjugate horizontal eye rotation away from cathode toward anode. The g-VOR was repeatable across all subjects, its magnitude a linear function of the current intensity, its latency about 9.0 ms with GVS of >or=2.5 mA, and was not suppressed by visual fixation. At 10-mA stimulation, the g-VOR [x, y, z] on the cathodal side was [0.77 +/- 0.10, -0.05 +/- 0.05, -0.18 +/- 0.06 degrees ] (mean +/- 95% confidence intervals) and on the anodal side was [0.79 +/- 0.10, 0.16 +/- 0.05, -0.19 +/- 0.06 degrees ], with a vertical divergence of 0.20 degrees . Although the horizontal g-VOR could have arisen from activation of the horizontal semicircular canal afferents, the vertical-torsional g-VOR resembled the vestibuloocular reflex in response to roll-plane head rotation about an Earth-horizontal axis and might be a result of both vertical semicircular canal and otolith afferent activations. Pulsed GVS is a promising technique to investigate latency and initiation of the human vestibuloocular reflex because it does not require a large mechanical apparatus nor does it pose problems of head inertia or slippage.
Estimating the inputs of gas transport processes in buildings (1997)

Information about the strength of gas sources in buildings has a number of applications in the area of building automation and control, including temperature and ventilation control, fire detection, and security systems. In this paper, a method for estimating the strength of a gas source in an enclosure when some of the parameters of the gas transport process are unknown is described. It is based on a perfect-mixing model of the gas species transport dynamics. The estimation problem is formulated as a Kalman filtering problem, where the states estimated by the Kalman filter are the unknown process parameters and the source strength. Sudden changes in the strength of the source are detected and tracked with a hypothesis testing and covariance resetting algorithm that is based on statistics provided by the Kalman filter. Experimental results from two first-order systems demonstrate the efficacy of this method.
Involvement of photorespiration and glycolate pathway in carbonic anhydrase induction and inorganic carbon concentration in <i>Chlamydomonas reinhardtii</i> (1992)

Interaction between induction of carbonic anhydrase (CA) activity, induction of inorganic carbon (C i ) concentrating mechanisms and the photorespiratory glycolate pathway has been studied in wild type 6145c and photorespiratory mutant 18–7F (low in phosphoglycolate phosphatase activity) cells of C. reinhardtii . Cell transfer from high CO 2 (5%, v/v) to low CO 2 (0.03%) provoked an increase of extracellular and total (extracellular plus intracellular) CA in both wild type and mutant cells. During adaptation to low CO 2 conditions, both strains excreted ammonium to the medium at a similar rate in the presence of l ‐methionine‐ d‐l ‐sulfoximine (MSX), an inhibitor of glutamine synthetase (GS). MSX also provoked ammonium excretion by air adapted wild type and mutant cells, even though both strains had high levels of CA activity and of C i concentrating activities. GS increased in both strains after transfer from high to low CO 2 conditions. However, this increase was abolished by aminooxyacetate, an inhibitor of the glyoxylate‐serine aminotransferase, and by glycolaldehyde, an inhibitor of triose phosphate to ribulose 1,5‐bisphosphate conversion. CA synthesis did not occur in the presence of either aminooxyacetate or glycolaldehyde. Algae grown in high CO 2 in the presence of aminooxyacetate did not induce C i concentrating mechanisms. Integration of these three processes, i.e., CA synthesis, C i ‐concentration, and photorespiratory glycolate pathway is proposed in the framework of carbon metabolism of the alga.
Biopsy of Heart (2020)

Ope n Pe e r Re v ie w on Qe ios Ope n Pe
Decreased amplitude of left ventricular posterior wall motion with notch movement to determine the left posterior septal accessory pathway in Wolff-Parkinson-White syndrome (1999)

Decreased amplitude of left ventricular posterior wall motion with notch movement is an important finding for accessory pathways located on the left posterior septum. These findings provided clinically useful information for determining whether to approach catheter ablation from the right or the left ventricle.
High Average Power Fe:ZnSe and Cr:ZnSe Mid-IR Solid State Lasers (2015)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. Mirov, V. Fedorov, D. Martyshkin, I. Moskalev, M. Mirov, and S. Vasilyev, "High Average Power Fe:ZnSe and Cr:ZnSe Mid-IR Solid State Lasers," in Advanced Solid State Lasers, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper AW4A.1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Growth and physical properties of Ga2O3 thin films on GaAs(001) substrate by molecular-beam epitaxy (2003)

We report effusive evaporation of Ga2O3 thin films on GaAs(001) substrates in a production-type molecular-beam epitaxy system. A polycrystalline Ga2O3 charge heated in a high-temperature effusion cell is used as the evaporation source. The Ga2O3–GaAs structures are characterized by atomic force microscopy (AFM), Rutherford backscattering spectroscopy (RBS), ellipsometry, and transmission electron microscopy (TEM). The Ga2O3 films are amorphous and stoichiometric by transmission electron diffraction and RBS, respectively. Under optimal growth conditions, the Ga2O3 film surface has a typical roughness of 2–3 Å as revealed by AFM, while the Ga2O3–GaAs interface is atomically abrupt as confirmed by the cross-sectional TEM. Such amorphous and stoichiometric Ga2O3 oxide paves the way for GaAs gate dielectrics applications.
Ultralow Voltage Crossbar Nonvolatile Memory Based on Energy-Reversible NEM Switches (2009)

A novel nonvolatile nanoelectromechanical (NEM) memory (nRAM) is introduced. Differently than the previously proposed NEM memories, the nRAM achieves the nonvolatility via workfunction engineering and eliminates the need for cell selection devices in a crossbar array using a displacement current-based read scheme. Furthermore, the configuration of the nRAM is such that the elastic potential energy due to the beam bending is reversibly used for switching, which enables to combine ultralow operation voltages with high switching speed. For F = 20 nm feature size and optimized margins, the nRAM cell is estimated to operate at plusmn180 mV, dissipate 10 aJ switching energy, and achieve < 10 ns switching delay.
Long‐Term Safety and Clinical Effects of Nilotinib in Parkinson's Disease (2020)

This study provides evidence that nilotinib is safe and tolerated in Parkinson's disease. The exploratory clinical data will inform an adequately powered larger study to evaluate the efficacy of nilotinib 300 mg in Parkinson's disease. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Dose-dense temozolomide regimen for the treatment of brain metastases from melanoma, breast cancer, or lung cancer not amenable to surgery or radiosurgery: a multicenter phase II study (2009)

This alternating weekly, dose-dense temozolomide regimen was well tolerated and clinically active in heavily pretreated patients with brain metastases, particularly in patients with melanoma. Combining temozolomide with WBRT or other agents may improve clinical outcomes.
Other temporary water habitats (2005)

The diversity of temporary water habitats is vast, and while some such as intermittent streams and ponds have been reasonably well studied, the knowledge of others is incomplete. This chapter synthesizes the available information on aquatic microhabitats such as phytotelmata (e.g., pitcher plant reservoirs and bromeliad leaf axil tanks), man-made waters, hot and cold desert habitats, and liquid dung. It seeks to find commonality among their various populations and communities.
Dependence of guided resonances on the structural parameters of terahertz photonic crystal slabs (2008)

Using terahertz spectroscopy, we measure the normal-incidence transmission coefficient of photonic crystals consisting of a periodic lattice of air holes in a silicon slab. Sharp resonant features are observed in the transmission spectra due to coupling of the leaky photonic crystal modes, called guided resonances, to the continuum of free-space modes. The resonances show considerable sensitivity to the structural parameters of the slab, including the slab thickness. By varying each crystal parameter systematically, we study the dependence of the resonances on the geometry of the photonic crystal slabs. Even small changes in a parameter such as the slab thickness, for example, can lead to dramatic changes in the optical spectrum. We also compare the transmission spectrum of a photonic crystal slab with a hexagonal lattice to that of a slab with a square lattice. In most cases, the experimental results match very well with numerical simulations based on the finite element method.
Wood Based Lignin Reactions Important to the Biorefinery and Pulp and Paper Industries (2013)

The cleavage of lignin bonds in a wood matrix is an important step in the processes employed in both the biorefinery and pulp and paper industries. -O-4 ether linkages are susceptible to both acidic and alkaline hydrolysis. The cleavage of -ether linkages rapidly occurs under mildly acidic reaction conditions, resulting in lower molecular weight lignin fragments. Acidic reactions are typically employed in the biorefinery industries, while alkaline reactions are more typically employed in the pulp and paper industries, especially in the kraft pulping process. By better understanding lignin reactions and reaction conditions, it may be possible to improve silvicultural and breeding programs to enhance the formation of easily removable lignin, as opposed to more chemically resistant lignin structures. In hardwood species, the S/G ratio has been successfully correlated to the amount of -O-4 ether linkages present in the lignin and the ease of pulping reactions.
Congestion at Airports: The Economics of Airport Expansions (2003)

The authors first discuss how airport congestion arises and how it can be dealt with. Because services provided by one airport are related to the services provided by many airports, delays at one airport have adverse effects on the movement of passengers and freight at other airports.
Metabolic Immunodepression and Metabolic Immunotherapy (1982)

The effects of administration of phenformin and clofibrate to 32 breast cancer patients who underwent radical mastectomy and suffered from hormonal metabolic disturbances involving a decline in immunologic response were investigated. It was demonstrated that treatment with these drugs during 2--7 months results in an improvement in metabolic parameters and delayed hypersensitivity reaction to DNCB, tuberculin and candidin (75.5% of cases), an increase in T lymphocyte count (56.3%) and an improvement of the reaction of lymphocyte blast transformation (66.6%). The improvement in the immunologic status of the patients persisted for 6--8 weeks after the stoppage of phenformin administration; a gradual decline in immunologic response and return to the original level were recorded 4--6 months after stoppage and phenformin therapy. The effect of clofibrate on metabolic and immunologic parameters did not manifest itself as soon as 6--8 weeks after stoppage. Elimination of metabolic immunodepression, which gradually develops in the course of normal ageing and tumor process, should be the main objective of metabolic immunotherapy. To this end, therapeutic means, other than phenformin and clofibrate, may be used provided they exert the same effects on carbohydrate-fat metabolism. The desirability of study of the effects of a long-term course of drugs of this kind on the therapy of cancer patients is discussed.