gebhart/patrepeval huggingface dataset:
On Optimizing VLC Networks for Downlink Multi-User Transmission: A Survey (2019)

The evolving explosion in high data rate services and applications will soon require the use of untapped, abundant unregulated spectrum of the visible light for communications to adequately meet the demands of the fifth-generation (5G) mobile technologies. Radio-frequency (RF) networks are proving to be too scarce to cover the escalation in data rate services. Visible light communication (VLC) has emerged as a great potential solution, either in replacement of, or a complement to, existing RF networks, to support the projected traffic demands. Despite the prolific advantages of VLC networks, VLC faces many challenges that must be resolved in the near future to achieve full standardization and to be integrated to future wireless systems. Here, we review the emerging research in the field of VLC networks and lay out the challenges, technological solutions, and future work predictions. Specifically, we first review the VLC channel capacity derivation and discuss the performance metrics and the associated variables. The optimization of VLC networks are also discussed, including resources and power allocation techniques, user-to-access point (AP) association and APs-to-clustered-users-association, APs coordination techniques, non-orthogonal multiple access (NOMA) VLC networks, simultaneous energy harvesting and information transmission using the visible light, and the security issues in VLC networks. Finally, we propose several open research problems to optimize the various VLC networks by maximizing either the sum rate, fairness, energy efficiency, secrecy rate, or harvested energy.
Coupling efficiency of monolithic, waveguide-integrated Si photodetectors (2009)

A waveguide-integrated photodetector provides a small-footprint, low-capacitance design that overcomes the bandwidth-efficiency trade-off problem of free space optics. High performance silicon devices are critical to the emergence of electronic-photonic integrated circuits on the complementary metal oxide semiconductor platform. We have fabricated vertical p-i-n silicon photodetectors that are monolithically integrated with compact silicon oxynitride channel waveguides. We report over 90% coupling efficiency of 830 nm light from the silicon oxynitride (SiOxNy) channel waveguide to the silicon photodetector. We analyze the dependence of coupling on waveguide index by comparing coupling from low index-contrast waveguides and high index-contrast waveguides.
CEO stabilization of a femtosecond laser using a SESAM as fast opto-optical modulator (2013)

We present a new method for intra-cavity control of the carrier-envelope offset (CEO) frequency of ultrafast lasers that combines high feedback bandwidth with low loss, low nonlinearity, and low dispersion. A semiconductor saturable-absorber mirror (SESAM) inside a modelocked laser is optically pumped with a continuous-wave (cw) laser. In this way, the SESAM acts as intra-cavity opto-optical modulator (OOM): the optical power of the cw-laser corresponds to a high-bandwidth modulation channel for CEO frequency control. We experimentally verified this method for a femtosecond Er:Yb:glass oscillator (ERGO), in which one SESAM is in parallel used for modelocking and as intra-cavity OOM for achieving a tight CEO lock. This laser can also be CEO-stabilized in the usual scheme, in which the laser pump current is modulated, i.e., the gain element acts as intra-cavity OOM. We compare the performance with gain and SESAM OOM measuring CEO transfer function, frequency noise power spectral density (PSD), and Allan deviation for integration times up to 1000 s. In the case of the gain OOM, the millisecond upper-state lifetime of the Er:Yb:glass limits the achievable CEO-control bandwidth to <10 kHz. The feedback bandwidth of the SESAM OOM was more than a factor of 10 higher than the gain OOM bandwidth and was mainly limited by the used current driver. The residual integrated phase noise (1 Hz - 100 kHz) of the ~20-MHz CEO beat was improved by more than an order of magnitude (from 720 mrad to less than 65 mrad), and the fractional frequency stability by a factor of 4 (from 1∙10<su⁻⁸ to 2.5∙10⁻⁹ at 1 s).
Fast triangle reordering for vertex locality and reduced overdraw (2007)

We present novel algorithms that optimize the order in which triangles are rendered, to improve post-transform vertex cache efficiency as well as for view-independent overdraw reduction. The resulting triangle orders perform on par with previous methods, but are orders magnitude faster to compute. The improvements in processing speed allow us to perform the optimization right after a model is loaded, when more information on the host hardware is available. This allows our vertex cache optimization to often outperform other methods. In fact, our algorithms can even be executed interactively, allowing for re-optimization in case of changes to geometry or topology, which happen often in CAD/CAM applications. We believe that most real-time rendering applications will immediately benefit from these new results.
Synthetic PPG Signal Generation to Improve Coronary Artery Disease Classification: Study With Physical Model of Cardiovascular System (2022)

This paper presents a novel approach of generating synthetic Photoplethysmogram (PPG) data using a physical model of the cardiovascular system to improve classifier performance with a combination of synthetic and real data. The physical model is an in-silico cardiac computational model, consisting of a four-chambered heart with electrophysiology, hemodynamic, and blood pressure auto-regulation functionality. Starting with a small number of measured PPG data, the cardiac model is used to synthesize healthy as well as PPG time-series pertaining to coronary artery disease (CAD) by varying pathophysiological parameters. A Variational Autoencoder (VAE) structure is proposed to derive a statistical feature space for CAD classification. Results are presented in two perspectives namely, (i) using artificially reduced real disease data and (ii) using all the real disease data. In both cases, by augmenting with the synthetic data for training, the performance (sensitivity, specificity) of the classifier changes from (i) (0.65, 1) to (1, 0.9) and (ii) (1, 0.95) to (1, 1). The proposed hybrid approach of combining physical modelling and statistical feature space selection generates realistic PPG data with pathophysiological interpretation and can outperform a baseline Generative Adversarial Network (GAN) architecture with a relatively small amount of real data for training. This proposed method could aid as a substitution technique for handling the problem of bulk data required for training machine learning algorithms for cardiac health-care applications.
Computation of the fractional anisotropy and mean diffusivity maps without tensor decoding and diagonalization: Theoretical analysis and validation (2003)

Diffusion tensor MRI (DT-MRI) is a promising modality for in vivo mapping of the organization of deep tissues. The most commonly used DT-MRI invariant maps are the mean diffusivity, mu(D), relative anisotropy (RA), and fractional anisotropy (FA). Because of the computational burden, anisotropy maps are generally computed offline. The availability of a simple procedure to compute RA, FA, and mu(D) online would make DT-MRI more useful in clinical applications that require immediate feedback. In this study, analytical expressions that relate the commonly used tensor anisotropy measures obtained from the decoded and diagonalized DT with those obtained from the first and second moments of the measured diffusion-weighted (DW) data are derived. Specifically, it is shown that for the principal icosahedron encoding scheme, RA is related to the mean and standard deviation (SD) of the DW measurements that can be computed online. Since FA is commonly used as an anisotropy measure, an analytical expression relating RA and FA was derived from the tensor invariants. These results were validated using both Monte Carlo simulations and high-resolution, normal whole-brain DT-MRI measurements acquired with different b-factors, encoding schemes, and signal-to-noise ratio (SNR) levels. The bias introduced by the rotationally variant encoding schemes into the diffusion measures is also investigated.
<title>Advances in gallium lanthanum sulphide glass for optical fiber and devices</title> (2001)

The advantages of gallium lanthanum sulphide (GLS) based glass over other competing glasses for active and infrared applications are evident through its low-phonon energy, high rare-earth solubility, high transition temperature and non-toxicity. However this glass often devitrifies during fibre drawing due to a small separation between the crystallisation and fibre thawing temperatures. Improving GLS fabrication technology may hold the key to achieving practical optical waveguide devices. In this paper, we describe the cunent GLS research status, methods ofimproving glass purity and our directions toward alternatives to traditional fibre technology, in particular planar channel waveguides and holey or microstructured fibres.
Optimizing a virtual speech display (2005)

In our 2003 ICAD Paper “Optimizing the Spatial Configuration of a Seven Talker Speech Display,” we described a hybrid near-far spatial configuration that maximizes performance in a multitalker listening task. In this brief addendum, we describe our scientific motivation for that study, describe a supplementary experiment that extended the earlier work to two additional spatial configurations, and place the results of the study in the context of current and future research in audio displays.
Computerized Classification Method for Differentiating Between Benign and Malignant Lesions on Breast MR Images (2005)

Contrast-enhanced breast MRI has been shown to have very high sensitivity in the detection of breast cancers. A new computerized classification method for differentiating between benign and malignant lesions on breast MRIs was developed. This method was based on temporal feature analysis. We experimented with a set of thresholds of the contrast uptake and washout speed to automatically determine suspicious malignant areas. An angiogenesis map was generated to indicate suspicious malignant areas by color. The results obtained from the retrospective analysis on 64 malignant and 29 benign breast lesions showed that our method achieved 90.5% (57/63) sensitivity in detecting malignant lesions, and it correctly classified 55% (16/29) benign lesions as benign. The study results demonstrated the effectiveness of this temporal feature analysis method for the detection of malignant lesions and its performance in delineating malignant lesions from benign lesions.
Reactor Design for Manufacturing Carbon Hybrid Materials (2022)

This paper addresses the design of a reactor system for manufacturing carbon nanotube (CNT) fabric and carbon hybrid materials (CHM). A web or sock of CNT is formed in a reactor tube in the gas phase pyrolysis method. The sock exits the reactor tube and is wound layer by layer onto a drum to directly form a nonwoven fabric. Metal nanoparticles and continuous microfibers can be integrated into the synthesis process to form CHM. Continuous direct manufacturing of fabric is an advantage of the method. However, the reliability of this manufacturing process in our particular reactor system is affected by several problems. These include occasional breaking of the sock, the need for daily cleaning of the ceramic reactor tube due to carbon deposits on the inside, sagging/bending of the reactor tube, and safety in handling the hydrogen gas produced from the reaction. Possible solutions to the problems are proposed. The importance of this research is that no other bulk material has the combination of properties of CNT hybrid fabric. If the properties can be further improved and customized, and if manufacturing of the material can be scaled-up at reasonable cost, many new commercial applications for nanotube custom materials could open up.
Molecular and Functional Diversity of the Expanding GABA‐A Receptor Gene Family (1999)

Fast inhibitory neurotransmission in the mammalian CNS is mediated primarily by the neurotransmitter gamma-aminobutyric acid (GABA), which, upon binding to its receptor, leads to opening of the intrinsic ion channel, allowing chloride to enter the cell. Over the past 10 years it has become clear that a family of GABA-A receptor subtypes exists, generated through the coassembly of polypeptides selected from alpha 1-alpha 6, beta 1-beta 3, gamma 1-gamma 3, delta, epsilon, and pie to form what is most likely a pentomeric macromolecule. The gene transcripts, and indeed the polypeptides, show distinct patterns of temporal and spatial expression, such that the GABA-A receptor subtypes have a defined localization that presumably reflects their physiological role. A picture is beginning to emerge of the properties conferred to receptor subtypes by the different subunits; these include different functional properties, differential modulation by protein kinases, and the targeting to different membrane compartments. These properties presumably underlie the different physiological roles of the various receptor subtypes. Recently we have identified a further member of the GABA-A receptor gene family, which we have termed theta, which appears to be most closely related to the beta subunits. The structure, function, and distribution of theta-containing receptors, and receptors containing the recently reported epsilon subunit, are described.
Structure–Cytotoxicity Relationships of Analogues of <i>N</i><sup>14</sup>-Desacetoxytubulysin H (2016)

Herein we report structure-cytotoxicity relationships for analogues of N<sup>14</sup>-desacetoxytubulyisn H 1. A novel synthetic approach toward 1 enabled the discovery of compounds with a range of activity. Calculated basicity of the N-terminus of tubulysins was shown to be a good predictor of cytotoxicity. The impact of structural modifications at the C-terminus of 1 upon cytotoxicity is also described. These findings will facilitate the development of new tubulysin analogues for the treatment of cancer.
Validation of object-induced MR distortion correction for frameless stereotactic neurosurgery (1998)

Spatial fidelity is a paramount issue in image guided neurosurgery. Until recently, three-dimensional computed tomography (3D CT) has been the primary modality because it provides fast volume capture with pixel level (1 mm) accuracy. While three-dimensional magnetic resonance (3D MR) images provide superior anatomic information, published image capture protocols are time consuming and result in scanner- and object-induced magnetic field inhomogeneities which raise inaccuracy above pixel size. Using available scanner calibration software, a volumetric algorithm to correct for object-based geometric distortion, and a Fast Low Angle SHot (FLASH) 3D MR-scan protocol, we were able to reduce mean CT to MR skin-adhesed fiducial marker registration error from 1.36 to 1.09 mm. After dropping the worst one or two of six fiducial markers, mean registration error dropped to 0.62 mm (subpixel accuracy). Three dimensional object-induced error maps present highest 3D MR spatial infidelity at the tissue interfaces (skin/air, scalp/skull) where frameless stereotactic fiducial markers are commonly applied. The algorithm produced similar results in two patient 3D MR-scans.
Three-dimensional cartilage formation by bone marrow-derived cells seeded in polylactide/alginate amalgam (2001)

Bone marrow-derived cells are considered as candidate cells for cartilage tissue engineering by virtue of their ability to undergo chondrogenesis in vitro when cultured in high density or when embedded within a three-dimensional matrix in the presence of growth factors. This study evaluated the potential of human bone marrow-derived cells for cartilage tissue engineering by examining their chondrogenic properties within a three-dimensional amalgam scaffold consisting of the biodegradable polymer, poly-L-lactic acid (PLA) alone, and with the polysaccharide gel, alginate. Cells were suspended either in alginate or medium and loaded into porous PLA blocks. Alginate was used to improve cell loading and retention within the construct, whereas the PLA polymeric scaffold provided appropriate mechanical support and stability to the composite culture. Cells seeded in the PLA/alginate amalgams and the plain PLA constructs were treated with different concentrations of recombinant human transforming growth factor-beta1 (TGF-beta 1) either continuously (10 ng/mL) or only for the initial 3 days of culture (50 ng/mL). Chondrogenesis was assessed at weekly intervals with cultures maintained for up to 3 weeks. Histological and immunohistochemical analysis of the TGF-beta 1-treated PLA/alginate amalgam and PLA constructs showed development of a cartilaginous phenotype from day 7 to day 21 as demonstrated by colocalization of Alcian blue staining with collagen type II and cartilage proteoglycan link protein. Expression of cartilage specific genes, including collagen types II and IX, and aggrecan, was detected in TGF-beta 1-treated cultures by reverse transcription-polymerase chain reaction analysis. The initiation and progression of chondrogenic differentiation within the polymeric macrostructure occurred with both continuous and the initial 3-day TGF-beta 1 treatment regimens, suggesting that key regulatory events of chondrogenesis take place during the early period of cell growth and proliferation. Scanning electron microscopy revealed abundant cells with a rounded morphology in the PLA/alginate amalgam. These findings suggest that the three-dimensional PLA/alginate amalgam is a potential candidate bioactive scaffold for cartilage tissue engineering applications.
Return-limited inductances: a practical approach to on-chip inductance extraction (2000)

Decreasing slew rates and efforts to reduce the resistance-capacitance (RC) delays of on-chip interconnect through design and technology have resulted in the growing importance of inductance in analyzing interconnect response for timing and noise analysis. In this paper, we consider a practical approach for extracting approximate inductances of on-chip interconnect. This approach, which we call the method of return-limited inductances, is based on performing the inductance modeling of signal lines and power-ground lines independently and on taking advantage of the power and ground distribution of the chip to localize inductive coupling. A set of simple geometry-based matrix decomposition rules guide sparsification in these extractions.
Achieving Economic Operation and Secondary Frequency Regulation Simultaneously Through Feedback Control (2015)

This letter presents an important finding: the parameters of secondary frequency control based on integral or proportional integral control can be tuned to achieve economic operation and frequency regulation simultaneously. We show that if the power imbalance is represented by frequency deviation, an iterative dual ascent based economic dispatch solving is equivalent to integral control. An iterative method of multipliers based economic dispatch is equivalent to proportional integral control. Similarly, if the controller parameters of the secondary frequency controls are chosen based on generator cost functions, these secondary frequency controllers achieve both economic operation and frequency regulation simultaneously.
Heart rate based automatic seizure detection in the newborn (2010)

This work investigates the efficacy of heart rate (HR) based measures for patient-independent, automatic detection of seizures in newborns. Sixty-two time-domain and frequency-domain features were extracted from the neonatal heart rate signal. These features were classified using a sophisticated support vector machine (SVM) scheme. The performance was evaluated on a large dataset of 208 h from 14 newborn infants. It was shown that the HR can be useful for the detection of neonatal seizures for certain patients yielding an area under the receiver operating characteristic (ROC) curve of up to 82%. On evaluating the system using multiple patients an average ROC area of 0.59 with sensitivity of 60% and specificity of 60%, were obtained. Feature selection was performed and in the majority of patients the performance was degraded. Further analysis of the feature weights found significant variability in feature ranking across all patients. Overall, the patient-independent system presented here was seen to perform well in some patients (2 out of 14) but performed poorly when tested on the entire group.
High Current 6 kV 4H-SiC PiN Diodes for Power Module Switching Applications (2006)

Forward voltage (VF) drift, in which a 4H-SiC PiN diode suffers from an irreversible increase in VF under forward current flow, continues to inhibit commercialization of 4H-SiC PiN diodes. We present our latest efforts at fabricating high blocking voltage (6 kV), high current (up to 50 A) 4H-SiC PiN diodes with the best combination of reverse leakage current (IR), forward voltage at rated current (VF), and VF drift yields. We have achieved greater than 60% total die yield onwafer for 50 A diodes with a chip size greater than 0.7 cm2. A comparison of the temperature dependent conduction and switching characteristics between a 50 A/6 kV 4H-SiC PiN diode and a commercially available 60 A/4.5 kV Si PiN diode is also presented.
Novel technique for rapid screening of tinnitus in rats (2005)

Measuring tinnitus in laboratory animals is difficult, involving weeks or months of operant training. Preliminary data suggest that rapid screening for tinnitus in rats can be accomplished using an unconditioned acoustic startle reflex. In control animals, a gap in an otherwise constant acoustic background inhibits a subsequent startle response to a sound impulse. If, however, the background signal is qualitatively similar to the animal’s tinnitus, poorer detection of the gap and less inhibition of the startle might be expected. Fourteen animals with putative tinnitus at 10 kHz and 13 control animals were tested for gap detection using three different background signals: broadband noise, and filtered bandpass noise centered either at 16 kHz (15.5–16.5 kHz) or at their suspected tinnitus locus of 10 kHz (9.5–10.5 kHz). As predicted, animals with evidence of tinnitus exhibited significantly worse gap detection at 10 kHz, and were not significantly different than control animals at 16 kHz and broadband noise. These results suggest a new methodology for rapidly detecting tinnitus in individual animals. Equipment donated by Hamilton-Kinder Inc Behavioral Testing Systems in the memory of SIU graduate Dorothy Jean Kinder (Walker). [Work supported by NIH grants AG023910-01 (JT), DC4830 (TB & CB), and DC00151 (DC).]
Soliton WDM transmission with and without guiding filters (1996)

We have done extensive experiments with dense (25-GHz channel spacing) high speed, (individual channel rates of 2.5 and 5.0 GB/s) soliton WDM over transoceanic distances. The experiments were performed in a loop 1400 to 2400 km in length with a 45 km amplifier span. We report error-free transmission of 8 2.5-GB/s channels at 10.0 Mm without filters and at 16.8 Mm with guiding filters. Twelve 2.5 GB/s channels were transmitted error free a distance of 7.2 Mm. Finally, eight 5.0 Gb/s channels were transmitted, error-free distance, with guiding filters, a distance of 9.8 Mm.
Small Molecules for Cell Reprogramming and Heart Repair: Progress and Perspective (2013)

Regenerative medicine for heart failure seeks to replace lost cardiomyocytes. Chemical approaches for producing ample supplies of cells, such as pluripotent stem cells and cardiomyocytes, hold promise as practical means to achieve safe, facile cell-based therapy for cardiac repair and regenerative medicine. In this review, we describe recent advances in the application of small molecules to improve the generation and maintenance of pluripotent stem cells. We also describe new directions in heart repair and regeneration in which chemical approaches may find their application.