gebhart/patrepeval huggingface dataset:
A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction (2018)

The H<sub>2</sub>FPEF score, which relies on simple clinical characteristics and echocardiography, enables discrimination of HFpEF from noncardiac causes of dyspnea and can assist in determination of the need for further diagnostic testing in the evaluation of patients with unexplained exertional dyspnea.
Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells (2013)

Human graft endothelial cells (ECs) can act as antigen-presenting cells to initiate allograft rejection by host memory T cells. Rapamycin, an mTOR inhibitor used clinically to suppress T cell responses, also acts on DCs, rendering them tolerogenic. Here, we report the effects of rapamycin on EC alloimmunogenicity. Compared with mock-treated cells, rapamycin-pretreated human ECs (rapa-ECs) stimulated less proliferation and cytokine secretion from allogeneic CD4+ memory cells, an effect mimicked by shRNA knockdown of mTOR or raptor in ECs. The effects of rapamycin persisted for several days and were linked to upregulation of the inhibitory molecules PD-L1 and PD-L2 on rapa-ECs. Additionally, rapa-ECs produced lower levels of the inflammatory cytokine IL-6. CD4+ memory cells activated by allogeneic rapa-ECs became hyporesponsive to restimulation in an alloantigen-specific manner and contained higher percentages of suppressive CD4+CD25(hi)CD127(lo)FoxP3+ cells that did not produce effector cytokines. In a human-mouse chimeric model of allograft rejection, rapamycin pretreatment of human arterial allografts increased graft EC expression of PD-L1 and PD-L2 and reduced subsequent infiltration of allogeneic effector T cells into the artery intima and intimal expansion. Preoperative conditioning of allograft ECs with rapamycin could potentially reduce immune-mediated rejection.
Your song your way: Rhythm-based two-factor authentication for multi-touch mobile devices (2015)

Multi-touch mobile devices have penetrated into everyday life to support personal and business communications. Secure and usable authentication techniques are indispensable for preventing illegitimate access to mobile devices. This paper presents RhyAuth, a novel two-factor rhythm-based authentication scheme for multi-touch mobile devices. RhyAuth requires a user to perform a sequence of rhythmic taps/slides on a device screen to unlock the device. The user is authenticated and admitted only when the features extracted from her rhythmic taps/slides match those stored on the device. RhyAuth is a two-factor authentication scheme that depends on a user-chosen rhythm and also the behavioral metrics for inputting the rhythm. Through a 32-user experiment on Android devices, we show that RhyAuth is highly secure against various attacks and also very usable for both sighted and visually impaired people.
Structure and chromosomal localization of the β2 subunit of the human brain sodium channel (1997)

The beta2 subunit of rat brain voltage-gated sodium channels modulates their cell-surface expression and gating. It is a 33 kDa glycoprotein with a single transmembrane segment and an immunoglobulin-like fold resembling those of cell adhesion molecules in the extracellular domain. Here we report the cDNA sequence and genomic localization of the gene encoding the human beta2 subunit. The mature human beta2 protein has 89% amino acid sequence identity to rat beta2 and has four conserved consensus sites for N-linked glycosylation. The extracellular cysteine residues which are predicted to form the disulfide linkage in the immunoglobulin-like fold are also conserved, indicating that the overall structure is preserved between these two species. Using fluorescent in situ hybridization (FISH), we localized the beta2 gene to human chromosome 11q3. Mutations in this region of chromosome 11 in Charcot-Marie-Tooth syndrome type 4B and in other neurological diseases cause abnormal myelination and neurological deficits. The similarity of beta2 to cell adhesion molecules, including myelin protein p0, and its chromosomal location at 11q23 suggest a potential role in these demyelinating diseases.
Nanoimprinting Using Liquid-Phase Hydrogen Silsesquioxane (2006)

We have newly developed an imprinting technique using liquid-phase hydrogen silsesquioxane (HSQ) as an alternate replication material for spin-coated HSQ resin currently used. Various patterns with linewidth ranging from 25 nm to 300 µm were demonstrated by imprinting using liquid-phase HSQ. We simultaneously fabricated arbitrary patterns including both submicron and greater than one hundred micron patterns by a one-step process. Moreover, after imprinting, the residual HSQ layer that remained in the compressed area was less than 10 nm thick.
Phosphorylation Modulates the Activity of Glycine N-Methyltransferase, a Folate Binding Protein (1989)

Glycine N-methyltransferase (EC 2.1.1.20) was recently identified as a major folate binding protein of rat liver cytosol (Wagner, C., and Cook, R. J. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 3631-3634). Activity of the enzyme is inhibited when the natural folate ligand, 5-methyltetrahydropteroylpentaglutamate (5-CH3-H4PteGlu5), is bound. It has been suggested that glycine N-methyltransferase plays a role in regulating the availability of methyl groups in the liver. Purified transferase was phosphorylated in vitro by the catalytic subunit of cAMP-dependent protein kinase. If 5-CH3-H4PteGlu5 was first bound to the transferase, phosphorylation was inhibited. Phosphorylation of glycine N-methyltransferase in vitro increased its activity approximately 2-fold. 5-CH3-H4PteGlu5 inhibited the activity of newly phosphorylated enzyme as well as native enzyme. Freshly isolated rat hepatocytes incorporated 32P-labeled inorganic phosphate into this folate binding protein. Chemical analysis of purified enzyme showed about 0.55 mol of phosphate present per mol of glycine N-methyltransferase subunit. These results indicate that phosphorylation of glycine N-methyltransferase may provide a mechanism for modulating the activity of this enzyme and support its role in regulating the availability of methyl groups.
The Benefit of Medium-Chain Triglycerides (2001)

Washington University St. Louis, Missouri David Fields, PhD, received his doctorate from Auburn University and is currently performing a post-doctoral fellowship at Washington University in St. Louis.
New design concepts for ferrite-tuned low-energy-booster cavities (2002)

The design concepts for ferrite-tuned accelerating cavities discussed differ from conventional solutions using thick ferrite toroids for frequency tuning. Instead, tuners consisting of an array of ferrite-loaded striplines are investigated. These promise more efficient cooling and higher operational reliability. Possible improvements in both voltage holding and average power handling are examined. A variety of options discussed permit substantial improvements on both voltage holding capabilities and tolerable RF power levels of ferrite-tuned cavities for rapid-cycling booster synchrotrons. Layout examples for the SSC-LEB RF system are presented (tuning range 47.5 to 59.6 MHz, repetition frequency 10 Hz).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Preparation of Silk Fibroin Modified PBT-<i>co</i>-PBS/PEG Composite Films and their Effects on Clinical Human Salivary Epithelial Cells Transplantation (2013)

We reported the preparation of surface modified poly(butylene terephthalate)- co -poly(butylene succinate)- b -poly(ethylene glycol) (i.e. PBT- co -PBS/PEG) films by three methods: silk fibroin coating, SO 2 plasma treatment and silk fibroin anchoring. The obtained composite films were named SF/(PBT- co -PBS/PEG), SO 2 /(PBT- co -PBS/PEG) and SF/SO 2 /(PBT- co -PBS/PEG), respectively. Their surface properties were characterized by contact angles, surface energies and XPS. The biocompatibility of the films were further evaluated by the morphology, attachment, proliferation and viability of human salivary epithelial cells (HSG cells). Results revealed that SF/SO 2 /(PBT- co -PBS/PEG) possessed the high surface free energy (59.67 mJ/m 2 ) and could immobilize a great amount of fibroin (SF surface coverage: 26.39 wt%), which attributed to the formation of such polar groups as hydrosulfide group, sulfonic group, carboxyl and carbonyl ones in the process of SO 2 plasma treatment. The cell tests suggested that the silk fibroin anchoring could significantly enhance the biocompatibility of PBT- co -PBS/PEG, which implied the potential application of fibroin modified PBT- co -PBS/PEG for clinical HSG cells transplantation in artificial salivary gland constructs.
Signatures of a time-reversal symmetric Weyl semimetal with only four Weyl points (2017)

Through intense research on Weyl semimetals during the past few years, we have come to appreciate that typical Weyl semimetals host many Weyl points. Nonetheless, the minimum nonzero number of Weyl points allowed in a time-reversal invariant Weyl semimetal is four. Realizing such a system is of fundamental interest and may simplify transport experiments. Recently, it was predicted that TaIrTe<sub>4</sub> realizes a minimal Weyl semimetal. However, the Weyl points and Fermi arcs live entirely above the Fermi level, making them inaccessible to conventional angle-resolved photoemission spectroscopy (ARPES). Here, we use pump-probe ARPES to directly access the band structure above the Fermi level in TaIrTe<sub>4</sub>. We observe signatures of Weyl points and topological Fermi arcs. Combined with ab initio calculation, our results show that TaIrTe<sub>4</sub> is a Weyl semimetal with the minimum number of four Weyl points. Our work provides a simpler platform for accessing exotic transport phenomena arising in Weyl semimetals.Weyl semimetals are interesting because they are characterized by topological invariants, but specific examples discovered to date tend to have complicated band structures with many Weyl points. Here, the authors show that TaIrTe<sub>4</sub> has only four Weyl points, the minimal number required by time-reversal symmetry.
User Centric Coordinated Multi Point Transmission (2010)

In the context of long term evolution (LTE) Advanced networks so called coordinated multi point transmission (CoMP) - where transmission is done jointly from several cells to user equipment (UE) - has gained a lot of interest lately. To benefit from CoMP by interference mitigation, UEs have to be served user centric to really leverage potential performance gains like increased capacity or spectral efficiency. This leads to a severe challenge how to assign user groups (UG) to cooperation areas (CA) in a user centric way because UGs must be found with an unique set of strongest cells. Here the so called partial CoMP concept is proposed and analyzed, which allows to serve up to 90% of all UEs in a user centric manner by their 3 strongest cells. The main achievement is to reach the significant performance gains of user centric cooperation for a practical and easy to realize system.
Acoustic Multi-Microphone Beamforming in a Practical Form Factor (2017)

Signal quality and noiselessness is important for Automatic Speech Recognition and communications. These can be achieved with the help of microphone arrays and beamforming. Multiple microphones can be used to pick sound coming from one direction while attenuating other directions. In this thesis, three arrays and three beamformers are compared. The target is to see how different structures affect the output signal and if one of the arrays is superior to the others.\n\n\nThe results show that the baffled array appears bigger than the reference array or the array on the top surface of a cylinder, but it adds complexity to the beamformers. For Automatic Speech Recognition, all three arrays performed the same, but there were clear differences between the beamforming algorithms. Thus the array to use depends on the use-case and especially on the industrial design of the device.
Structure and biological activity of a host-specific toxin produced by the fungal corn pathogen Phyllosticta maydis (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and biological activity of a host-specific toxin produced by the fungal corn pathogen Phyllosticta maydisStephen J. Danko, Y. Kono, J. M. Daly, Yoshikatsu Suzuki, S. Takeuchi, and David A. McCreryCite this: Biochemistry 1984, 23, 4, 759–766Publication Date (Print):February 14, 1984Publication History Published online1 May 2002Published inissue 14 February 1984https://pubs.acs.org/doi/10.1021/bi00299a027https://doi.org/10.1021/bi00299a027research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Lis1-Related Nudf Protein of <i>Aspergillus nidulans</i> Interacts with the Coiled-Coil Domain of the Nude/Ro11 Protein (2000)

The nudF gene of the filamentous fungus Aspergillus nidulans acts in the cytoplasmic dynein/dynactin pathway and is required for distribution of nuclei. NUDF protein, the product of the nudF gene, displays 42% sequence identity with the human protein LIS1 required for neuronal migration. Haploinsufficiency of the LIS1 gene causes a malformation of the human brain known as lissencephaly. We screened for multicopy suppressors of a mutation in the nudF gene. The product of the nudE gene isolated in the screen, NUDE, is a homologue of the nuclear distribution protein RO11 of Neurospora crassa. The highly conserved NH(2)-terminal coiled-coil domain of the NUDE protein suffices for protein function when overexpressed. A similar coiled-coil domain is present in several putative human proteins and in the mitotic phosphoprotein 43 (MP43) of X. laevis. NUDF protein interacts with the Aspergillus NUDE coiled-coil in a yeast two-hybrid system, while human LIS1 interacts with the human homologue of the NUDE/RO11 coiled-coil and also the Xenopus MP43 coiled-coil. In addition, NUDF coprecipitates with an epitope-tagged NUDE. The fact that NUDF and LIS1 interact with the same protein domain strengthens the notion that these two proteins are functionally related.
Combined Solar Power and TPV (2011)

The use of PV array energy in supplying the electrolyzer systems is very suitable.During the daylight hours, the sunlight converts by PV array into electrical energy which will be used for electrolyzing process.Then hydrogen produced by the electrolyzer is compressed and stored in hydrogen vessel.This provides energy for the fuel cell to meet the load when the solar energy is insufficient.Solar hydrogen technology is relatively simple and the only raw material for the production of solar hydrogen is water.In this study technical results obtained from direct connection of 10 kW PV array with 5 kW electrolyzer systems for hydrogen production and storage at Taleghan site.Variations of the solar radiation intensity, hydrogen production rate, solar hydrogen efficiency and overall efficiency of solar hydrogen energy were considered as base of analyses.It is found that the minimum and maximum overall energy efficiency values of the system are 0.93 % and 5.01 %, respectively.The result shows a great potential in direct solar radiation for absorbing and converting it to other types of energy in Iran.Using solar energy required high initial investment, so converting solar energy to other types of energy with high efficiency systems is vital.
A Study on Analysis of the Template Component for the Development of BIM Template (2011)

based design methodology requires more information than traditional design methodology in order to insure efficiency throughout the project. based design not only requires all building data in the form of 3D shapes, but also all other relevant data regarding building components. Information is typically grouped in a standard classification system such as by standardized material names. The development of a domestic based standard classification system is yet to be created and deployed in the industry. Each designer is specifying their own building information classification systems which is causing inconsistency in the industry. Therefore based designs, are causing confusion in the industry as each designer follow no guidelines for material standardization classification. The lack of information regarding this in the template will continue to cause confusion about a projects building information data consistently. This study is that of preliminary research to develop a template. First, overseas templates were analyzed regarding standards and documentation. Examination then followed regarding the element and characteristics needed for the development of a template, a suggested hierarchy of elements required for a template were then made. The result of this research is that it will be used to develop a BIM template prototype, to support the generation of building information data regarding neighborhood facilities.
The anandamide transport inhibitor <i>AM404</i> reduces ethanol self‐administration (2007)

The endocannabinoid system mediates in the pharmacological actions of ethanol and genetic studies link endocannabinoid signaling to alcoholism. Drugs activating cannabinoid CB1 receptors have been found to promote alcohol consumption but their effects on self-administration of alcohol are less clear because of the interference with motor performance. To avoid this problem, a novel pharmacological approach to the study of the contribution of the cannabinoid system in alcoholism may be to use drugs that locally amplify the effects of alcohol on endogenous cannabinoids. In the present study we addressed this model by studying the effects of the anandamide transport inhibitor N-(4-hydroxyphenyl) arachidonoyl-ethanolamide (AM404) on both ethanol self-administration and reinstatement of alcohol-seeking behavior in rats. The results show that AM404 significantly reduced ethanol self-administration in a dose-dependent manner but failed to modify reinstatement for lever pressing induced by the stimulus associated with alcohol. This effect was not due to a motor depressant effect and was not related to a decrease in general motivational state, as it was not effective in other reward paradigms such as lever pressing for a saccharin solution. The mechanism of action of AM404 does not involve cannabinoid CB1 receptors as the CB1-selective antagonist SR141716A did not block the reduction of ethanol self-administration induced by the anandamide uptake blocker. Moreover, 3-(1,1-dimethylheptyl)-(-)-11-hydroxy-delta 8-tetrahydrocannabinol (HU-210), a classical cannabinoid receptor agonist, did not affect ethanol self-administration. The effects of AM404 are not mediated by either vanilloid VR1 receptors or cannabinoid CB2 receptors because it is not antagonized by either the VR1 receptor antagonist capsazepine or the CB2 antagonist AM630. These results indicate that AM404 may be considered as an innovative approach to reduce alcohol consumption.
A NOVEL EVOLUTIONARY LEARNING TECHNIQUE FOR MULTI-OBJECTIVE ARRAY ANTENNA OPTIMIZATION (2004)

In this paper, a neural network is used to implement an optimized objective function for a genetic algorithm (GA) for application on array antenna design optimization. Traditional GAs are inefficient because a large amount of data that describes the problem space is discarded after each generation. Using the neural network enhanced genetic algorithm (NNEGA), this redundant information is fed back into the GA's objective function via the neural network. The neural network learns the optimal weights of the objective function by identifying trends and optimizing weights depending on the knowledge that it accumulates in-situ. The NNEGA is successfully applied to challenging array antenna design problems. This use of neural network to optimize a multi-objective function for the GA is a new idea that is different from other hybridization of GA and NN.
Spectroscopy and transient photoconductivity of partially crystalline polyaniline (1989)

The results of spectroscopy and transient-photoconductivity measurements are presented for polyaniline in the fully reduced form (leucoemeraldine) and in the emeraldine-base form. Results from partially crystalline films (cast from solution in sulfuric acid) and from amorphous films (cast from dimethylforamide) are compared. We observed a relatively strong photoconductive response from pumping at 3.7 eV into the \ensuremath{\pi}-${\ensuremath{\pi}}^{\mathrm{*}}$ absorption of leucoemeraldine and a smaller photocurrent from pumping (at 1.9 and 3.7 eV) into the two absorptions which characterize the emeraldine base. The 3.7-eV photocurrent in leucoemeraldine is a factor of 4--8 larger than that from the similar ultraviolet absorption in the emeraldine base, and the two photocurrents show a similar dependence of biasing field (linear at low light levels and more complex at high light levels). The photocurrent in the emeraldine base from 3.7-eV pumping is a factor of 3--4 larger (per photon) than that from 1.9-eV pumping. The results are interpreted in terms of the one-dimensional band structures calculated for the two forms of polyaniline.