gebhart/patrepeval huggingface dataset:
Mouse and Human Embryonic Stem Cells: Can They Improve Human Health by Preventing Disease? (2011)

Given the vast number of chemicals that are released into the environment each year, it is imperative that we develop new predictive models to identify toxicants before unavoidable exposure harms the health of humans and other organisms. In vitro models are especially attractive in predictive toxicology as they can greatly reduce assay costs and animal usage while identifying those chemicals that may require further in vivo evaluation. With the derivation of both mouse and human embryonic stem cells, new opportunities have developed that could revolutionize the field of predictive toxicology. Stem cells themselves can be used to model earliest stages of development, or they can be differentiated to study later aspects of development and thereby model post-implantation. Because embryos and fetuses are usually more sensitive to environmental toxicants than adults, stem cells provide an unique tool for studying the prenatal phase in our life cycle. The embryonic stem cell test (EST), which has been validated for use with mouse ESC (mESC), is an accurate predictor of embryotoxic compounds, particularly those that are highly embryotoxic. Human embryonic stem cells (hESCs), although not yet incorporated into a validated test, are a particularly attractive platform for toxicological testing as they can give us direct information on humans and avoid concerns about species variation in response. This review discusses toxicological studies and strategies that have been used with embryonic stem cells during the past five years and possible directions that could lead to improvements in the development of predictive assays in the future.
Direct Incorporation of Magnetic Constituents within Ordered Mesoporous Carbon−Silica Nanocomposites for Highly Efficient Electromagnetic Wave Absorbers (2010)

Low-density ordered mesoporous carbon−silica nanocomposites with different Fe contents have been prepared by a facile solvent-evaporation-induced self-assembly approach. Magnetic metal nanocrystallines are highly dispersed in the composites due to in situ carbothermal reduction. The optimal reflection loss calculated from the measured permittivity and permeability is −34.4 dB at 13.1 GHz. Moreover, the electromagnetic wave absorption less than −10 dB is found to exceed 5.0 GHz for an absorber thickness of 2 mm. The microwave enhancement absorption of the mesoporous C−SiO2−Fe nanocomposites is contributed to the better match between dielectric loss and magnetic loss, which originates from the high absorption by the incorporation of magnetic species as well as the multiple reflections by the ordered mesoporous structure. The mesoporous C−SiO2−Fe nanocomposites also exhibit a lower infrared emissivity in the wavelength from 8 to 14 μm than that of Fe-free powder.
Sphingosine Kinase from Swiss 3T3 Fibroblasts: A Convenient Assay for the Measurement of Intracellular Levels of Free Sphingoid Bases (1994)

Sphingoid bases are important for diverse cellular processes. This paper describes the development of a simple and rapid enzymatic method to quantify mass levels of free long-chain sphingoid bases in cellular lipid extracts. The assay is based on the ability of sphingosine kinase from Swiss 3T3 fibroblasts to phosphorylate sphingoid bases, predominantly sphingosine. To quantitatively determine cellular levels of sphingosine or other long-chain sphingoid bases, it was necessary to solubilize cellular lipids by sonication and to generate standard curves in the presence of lipid extracts containing at least 50 nmol of phospholipids. The assay conditions were optimized to allow quantification of sphingosine over a broad range from 25 to 1,000 pmol. Using this method we were able to obtain reproducible measurements of free sphingoid bases in various cell types and to detect increases in intracellular sphingoid base levels after treatment with exogenous sphingosine or stimulation with fetal bovine serum.
Computer aided implementation of complex algorithms on DSP's using automatic scaling (2005)

A methodology for transforming complex floating-point algorithms into correct fixed-point DSP programs is presented. In particular, an automatic scaling scheme leading to overflow-free programs is described. Depending on the application, scaling generated automatically may either perfectly fit, or be modified in order to substantially improve accuracy. Each case is illustrated by an example (FFT and Recursive Least-Squares algorithms).
Cereal leaf beetle: biology and management. (2009)

Cereal leaf beetle, their description, life cycle, the damage they do to leaves and fields, their management in wheat, insecticidal control and chemical control, scouting method, and scouting frequency
Symmetrical MnO<sub>2</sub>–Carbon Nanotube–Textile Nanostructures for Wearable Pseudocapacitors with High Mass Loading (2011)

While MnO(2) is a promising material for pseudocapacitor applications due to its high specific capacity and low cost, MnO(2) electrodes suffer from their low electrical and ionic conductivities. In this article, we report a structure where MnO(2) nanoflowers were conformally electrodeposited onto carbon nanotube (CNT)-enabled conductive textile fibers. Such nanostructures effectively decrease the ion diffusion and charge transport resistance in the electrode. For a given areal mass loading, the thickness of MnO(2) on conductive textile fibers is much smaller than that on a flat metal substrate. Such a porous structure also allows a large mass loading, up to 8.3 mg/cm(2), which leads to a high areal capacitance of 2.8 F/cm(2) at a scan rate of 0.05 mV/s. Full cells were demonstrated, where the MnO(2)-CNT-textile was used as a positive electrode, reduced MnO(2)-CNT-textile as a negative electrode, and 0.5 M Na(2)SO(4) in water as the electrolyte. The resulting pseudocapacitor shows promising results as a low-cost energy storage solution and an attractive wearable power.
Identification of a point mutation in the folate receptor gene that confers a dominant negative phenotype. (1995)

UM-SCC-38 cells, a squamous cell carcinoma cell line of the head and neck, express limited amounts of folate receptor alpha antigen which is not capable of binding either folic acid or 5-methyltetrahydrofolic acid. Three distinct mutations in the open reading frame of the folate receptor were identified. We now show that the three mutants are nonfunctional with respect to folic acid binding because the protein products do not bind folate. Additionally, a study of MA104 cells (a receptor-positive cell line) transfected with each mutant was done. Expression of one mutant, FR-67, results in a dominant negative phenotype because folate binding is significantly reduced although membrane antigen is significantly increased. Coexpression of FR-67 and the normal protein in MA104 cells also results in large, bright clusters of receptor protein inside the cell around the nucleus when visualized using indirect immunofluorescence. These clusters are not found in cells that express either normal or FR-67 protein alone. In conclusion, this study provides the first evidence of a mutant folate receptor protein capable of affecting normal receptor function in a dominant negative manner.
Redox Properties of Organofullerenes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRedox Properties of OrganofullerenesToshiyasu Suzuki, Yusei Maruyama, Takeshi Akasaka, Wataru Ando, Kaoru Kobayashi, and Shigeru NagaseCite this: J. Am. Chem. Soc. 1994, 116, 4, 1359–1363Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ja00083a022https://doi.org/10.1021/ja00083a022research-articleACS PublicationsRequest reuse permissionsArticle Views1091Altmetric-Citations206LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Bioabsorbable poly(4-hydroxybutyrate) (P4HB) fibrous membranes as a potential dermal substitute (2021)

Dermal substitutes are indispensable for repairing large full-thickness skin defects. Only a few biomaterials for dermal substitution have been put into clinical practice. Therefore, novel artificial dermal substitutes that can meet clinical requirements are in urgent need. Biodegradable poly(4-hydroxybutyrate) (P4HB), which has been approved by the U.S. FDA, can be considered as a possible alternative biomaterial to construct dermal substitutes. In this work, three-dimensional P4HB fibrous membranes were constructed by an electrospinning technique. These P4HB fibrous membranes showed excellent air-permeability, and better water uptake capacity compared to P4HB strip and polycaprolactone (PCL) fibrous membrane controls. The <i>in vitro</i> hemocompatibility and cytotoxicity of P4HB fibrous membranes were investigated. <i>In vivo</i> Sprague-Dawley (SD) rat model studies revealed that P4HB fibrous membranes can be used as artificial dermis to improve wound healing for full-thickness skin defects.
High Prevalence of Papillomavirus-Associated Penile Intraepithelial Neoplasia in Sexual Partners of Women with Cervical Intraepithelial Neoplasia (1987)

To determine whether neoplastic cervical lesions in women are associated with papillomavirus infections in their sexual partners, we used a colposcope to examine male sexual partners of women with cervical flat condyloma (294 cases) or cervical intraepithelial neoplasia (186 cases), before and after 5 percent acetic acid was applied to the penis and the anogenital area. Condylomata acuminata, papules, and macules were observed in 309 of the 480 men (64.4 percent). In 204 of them (42.5 percent), macules or slightly elevated papules were detected only after application of acetic acid. Condylomata acuminata or lesions showing histologic features of condyloma were found in 121 partners (41.2 percent) of women with condyloma, but in only 10 partners (5.4 percent) of women with cervical intraepithelial neoplasia. Penile lesions showing histologic features of intraepithelial neoplasia were found in 61 partners (32.8 percent) of women with cervical intraepithelial neoplasia, but in only 4 partners (1.4 percent) of women with flat condyloma. Thirty-six (60 percent) of the 60 macules or papules tested contained papillomavirus DNA sequences. Human papillomavirus types 16 and 33 were almost exclusively found in penile intraepithelial neoplasia. Type 6, type 11, and the recently recognized type 42 were found in lesions showing features of condyloma or minimal histologic changes. As yet uncharacterized papillomaviruses were found in 15 percent of the specimens. These data support the concept that cervical carcinomas and precancerous lesions in women may be associated with genital papillomavirus infection in their male sexual partners.
Homogeneous and homeotropic alignment of bent-core uniaxial and biaxial nematic liquid crystals (2011)

The effect of well-established homeotropically and homogeneously aligning polyimides, developed for calamitic liquid crystals, on the alignment of the nematic phases of bent-core mesogens was investigated using polarizing optical microscopy and conoscopy. Two polyimides, the homogeneously aligning SE7792 and the homeotropically aligning S659, were used to align three bent-core mesogens. Two of the mesogens, with an azo group in one of their arms, are found to align in a manner similar to the calamitic mesogens, while a fluorenone core based mesogen counter-intuitively aligns homogeneously on S659 coated surface and homeotropically on SE7792. Attractive interactions between unidirectionally oriented polyimide side-chains and the alkyl chains of mesogens determine the direction of alignment of the nematic director.
Deep Graph Kernels (2015)

In this paper, we present Deep Graph Kernels, a unified framework to learn latent representations of sub-structures for graphs, inspired by latest advancements in language modeling and deep learning. Our framework leverages the dependency information between sub-structures by learning their latent representations. We demonstrate instances of our framework on three popular graph kernels, namely Graphlet kernels, Weisfeiler-Lehman subtree kernels, and Shortest-Path graph kernels. Our experiments on several benchmark datasets show that Deep Graph Kernels achieve significant improvements in classification accuracy over state-of-the-art graph kernels.
Thermal Effects of Laser Stapedectomy in an Animal Model: CO<sub>2</sub> Versus KTP (1997)

Although use of the laser for stapedectomy has become common in recent years, controversy remains regarding whether the CO2 or visible-spectrum lasers (argon and KTP) are best suited for this operation. The main concern has been the potential for thermal injury to the inner ear with the visible-spectrum lasers attributable to their absorption characteristics. To further investigate this issue, the author performed 20 laser stapedectomies on adult chinchillas. Following placement of a 0.127-mm-diameter copper/constantan thermocouple (sampling at 12 Hz) beneath the footplate on the medial wall of the vestibule via a distant fenestration site, thermal changes with a micromanipulator-based CO2 and fiberoptic KTP system were compared. This was the first live animal model comparison of these two lasers. There was no statistical difference in the mean temperature elevation between the two systems (P = 0.395).
Bronchoscopy‐guided transtracheal and transbronchial fine‐needle aspiration biopsy: A 5‐year institutional review of 111 cases (2002)

We reviewed 111 bronchoscopy-guided transtracheal and transbronchial fine-needle aspiration (TT/TBNA) specimens from 97 patients to determine the sensitivity and specificity for diagnosing neoplasia compared to surgical biopsy and clinical follow-up and to determine the optimal number of passes. Fifty were positive for neoplasia, seven were suspicious, one was atypical, 51 were negative, and two were unsatisfactory. Of 57 positive/suspicious cases, 56 were confirmed neoplastic, with one patient lost to follow-up (specificity with follow-up: 100%). A positive diagnosis was rendered on the first pass in 29 cases (58%), second in six (12%), third in five (10%), fourth in three (6%), fifth in four (8%), and sixth, ninth, and eleventh passes in one case each (2% each). Twenty-seven negative cases had confirmed malignancies after their index FNA (sensitivity for neoplasia: 67%). We conclude that TT/TBNA is a highly specific but not always successful diagnostic technique. It appears to be limited by mechanical difficulties that prevent tumor access and cellular uptake in some masses. Little information is gained by procuring more than six samples.
Sum-Rate Analysis for High Altitude Platform (HAP) Drones With Tethered Balloon Relay (2017)

High altitude platform (HAP) drones can provide broadband wireless connectivity to ground users in rural areas by establishing line-of-sight links and exploiting effective beamforming techniques. However, at high altitudes, acquiring the channel state information (CSI) for HAPs, which is a key requirement to perform beamforming, is challenging. In this paper, by exploiting an interference alignment (IA) technique, a novel method for achieving the maximum sum-rate in HAP-based communications without CSI is proposed. In particular, to realize IA, a multiple-antenna tethered balloon is used as a relay between multiple HAP drones and ground stations (GSs). Here, a multiple-input multiple-output X network system is considered. The capacity of the considered M × N X network with a tethered balloon relay is derived in closed-form. Simulation results corroborate the theoretical findings and show that the proposed approach yields the maximum sum-rate in multiple HAPs-GSs communications in absence of CSI. The results also show the existence of an optimal balloon's altitude for which the sum-rate is maximized.
Persistence-Based Structural Recognition (2014)

This paper presents a framework for object recognition using topological persistence. In particular, we show that the so-called persistence diagrams built from functions defined on the objects can serve as compact and informative descriptors for images and shapes. Complementary to the bag-of-features representation, which captures the distribution of values of a given function, persistence diagrams can be used to characterize its structural properties, reflecting spatial information in an invariant way. In practice, the choice of function is simple: each dimension of the feature vector can be viewed as a function. The proposed method is general: it can work on various multimedia data, including 2D shapes, textures and triangle meshes. Extensive experiments on 3D shape retrieval, hand gesture recognition and texture classification demonstrate the performance of the proposed method in comparison with state-of-the-art methods. Additionally, our approach yields higher recognition accuracy when used in conjunction with the bag-of-features.
Algumas considerações sobre a estruturação gráfica das páginas do Mangá Samurai X (2012)

Nesse texto procura-se entender como os elementos gráficos presentes nas hqs ajudam a compor as páginas dos mangás. O intuito é verificar e analisar a construção do espaço das páginas da série Samurai X através de aspectos mais pregnantes, tais como, a sobreposição e o tamanho das imagens, o formato e a variação de dimensões dos quadrinhos, e também o formato, o posicionamento e o tamanho dos balões, das onomatopéias e das legendas. Usaremos como campo de provas alguns trechos desse mangá, nos momentos em que a ação se torna mais contundente através do confronto entre as personagens, tais como as ações corriqueiras e aquelas em que ocorre o combate físico entre os protagonistas e antagonistas.
Expression and function of the keratinocyte integrins (1993)

Human keratinocytes express several adhesive receptors of the integrin family. Expression is normally confined to the basal (proliferative) layer of keratinocytes, both in mature epidermis and during development. Altered expression patterns are observed during wound healing, in psoriasis and in squamous cell carcinomas. Keratinocyte integrins are subject to both transcriptional and post-translational regulation and ligand binding ability can be modulated independently of expression. Studies with cultured keratinocytes suggest a variety of functions for the receptors: adhesion to extracellular matrix proteins, intercellular adhesion, stratification, lateral migration and the regulation of terminal differentiation. Three distinct subpopulations of basal keratinocytes, with characteristics of stem cells, transit amplifying cells and cells committed to differentiate, can be distinguished on the basis of differences in integrin expression and function.
Probabilistic discovery of time series motifs (2003)

Several important time series data mining problems reduce to the core task of finding approximately repeated subsequences in a longer time series. In an earlier work, we formalized the idea of approximately repeated subsequences by introducing the notion of time series motifs. Two limitations of this work were the poor scalability of the motif discovery algorithm, and the inability to discover motifs in the presence of noise.Here we address these limitations by introducing a novel algorithm inspired by recent advances in the problem of pattern discovery in biosequences. Our algorithm is probabilistic in nature, but as we show empirically and theoretically, it can find time series motifs with very high probability even in the presence of noise or "don't care" symbols. Not only is the algorithm fast, but it is an anytime algorithm, producing likely candidate motifs almost immediately, and gradually improving the quality of results over time.
Magnetic properties and crystal structure of high moment FeTaN materials for thin-film recording heads (1993)

High-power density, high growth rate dc magnetron reactive sputtering has been used to grow single-layer FeTaN films. Ta has been found effective in improving the soft magnetic properties as well as the thermal stability of FeN films. For films containing ∼1.6 a/o Ta prepared under sputtering conditions of pN2/pAr=0.06, a power density of 2.5 or 3.9 W/cm2 and vacuum post-annealed at 350 °C for 1 h, the following properties are observed: saturation magnetization (Ms) values of ∼1550 emu/cc, coercivity (Hc) of ∼1 Oe, permeability of 1700–2300 at 20 MHz, and anisotropy field of ∼7 Oe. XRD scans yielded peaks characteristic of a random polycrystalline single phase bcc structure.
3D printing from MRI Data: Harnessing strengths and minimizing weaknesses (2016)

5 J. Magn. Reson. Imaging 2017;45:635-645.
Whose Country to Defend?: The Chicano Soldier on Stage (2009)

As the debate on the role of Mexicans in the US persists, and while the number of Chicanos serving and dying in Iraq and Afghanistan escalates, Chicana/os must expose the hegemonic erasure of their role in defining and defending "America." Chicanos/as have a long history of sacrificing their lives in service to the US only to suffer their contribution erased from the historical narrative. However, five Chicano plays, Luis Valdez's The Shrunken Head of Pancho Villa and Dark Root of a Scream , El Teatro Campesino's Vietnam Campesino and Soldado razo , and Culture Clash's Chavez Ravine , foreground the figure of the soldier to dramatize the hypocrisy wherein "America" is defined against Chicanos who in turn are rejected as only Mexican -American.
A Study on The Effects of Technostress on Flow and Continuous Use of Smartphone (2011)

In order to draw the influential factors of technostress on the continuous use of smartphone and the flow, the related variables have been selected from extensive literature reviews; a group of independent variables, including ICT utilization skill, ICT knowledge, and complexity, a group of mediating variables, which are technostress and the flow, and a group of dependent variables, including preference for voice communication and data communication are included in the research model. Based on this, a survey has been conducted by targeting 137 office workers who are using smartphones to verify the research hypotheses. Research findings show that ICT utilization skill and ICT knowledge make positive effects on technostress, and ICT knowledge does negative effect on flow. Complexity increases technostress; however, it influences flow negatively. Finally, technostress increases preference for voice communication, but flow increases preference for data communication. The result of this study will provide practical implications for the user-oriented design and operation as well as for the marketing strategy of mobile telecommunication companies and smartphone makers.
Boron—Nitrogen Macrocycles: A New Generation of Calix[3]arenes. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.