gebhart/patrepeval huggingface dataset:
Secret Sharing Scheme for Data Confidentiality Preserving in a Public-Private Hybrid Cloud Storage Approach (2014)

Adopting public cloud services implies a loose of control in the management process of the outsourced infrastructure. This raises legal and trust concerns among executives and decision factors regarding confidentiality of data being moved in cloud. We propose a protocol based on a secret sharing scheme in which data is split in optimal chunks, each chunk carrying a minimum informational content relative to the entire informational content of the data set. The file chunks are stored in multiple cloud storage volumes in a way that minimizes the probability for an insider or an attacker to reconstruct the original data set. The splitting heuristic is based on Kullback-Leibler as a metric of chunk optimality while the chunk distribution strategy uses a probabilistic model.
Integrated circuit design and application for electronic ballasts (2002)

Integrated circuits for electronic ballasts are a growing market today. Driven by the telecommunication industry, powerful technologies have been developed to handle both, the large scale integrated signal processing, and the power stage driving and control. These technologies are delivering the fundament for IC solutions, which meet both, the cost requirements of ballasts, as well as the aiming at miniaturization, Special custom integrated solutions make sense for high-end comfort ballasts with extended signal processing, focusing on bus connection, comprehensive dimming purpose, and advanced lamp control and protection. For the mass market, a modular system is desirable, which allows for flexible change of product characteristic features. Such a system can be reached by IC families which cover important ballast features, as free chosen frequency, dimming, lamp and ballast overload protection, end-of-life protection, over-voltage and under-voltage protection, power-factor correction (PFC), a simple power-control interface, and last, but not least, a simple adjustment of the output power for any new lamp type.
Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats (2004)

Spinal cord injury (SCI) is a devastating and complex clinical condition involving proinflammatory cytokines and nitric oxide toxicity that produces a predictable pattern of progressive injury entailing neuronal loss, axonal destruction, and demyelination at the site of impact. The involvement of proinflammatory cytokines and inducible nitric oxide synthase (iNOS) in exacerbation of SCI pathology is well documented. We have reported previously the antiinflammatory properties and immunomodulatory activities of statins (3-hydroxy-3-methylglutaryl [HMG]-CoA reductase inhibitors) in the animal model of multiple sclerosis, experimental allergic encephalitis (EAE). The present study was undertaken to investigate the efficacy of atorvastatin (Lipitor; LP) treatment in attenuating SCI-induced pathology. Immunohistochemical detection and real-time PCR analysis showed increased expression of iNOS, tumor necrosis factor alpha (TNFalpha) and interleukin 1beta (IL-1beta) after SCI. In addition, neuronal apoptosis was detected 24 hr after injury followed by a profound increase in ED1-positive inflammatory infiltrates, glial fibrillary acidic protein (GFAP)-positive reactive astrocytes, and oligodendrocyte apoptosis by 1 week after SCI relative to control. LP treatment attenuated the SCI-induced iNOS, TNFalpha, and IL-1beta expression. LP also provided protection against SCI-induced tissue necrosis, neuronal and oligodendrocyte apoptosis, demyelination, and reactive gliosis. Furthermore, rats treated with LP scored much higher on the locomotor rating scale after SCI (19.13 +/- 0.53) than did untreated rats (9.04 +/- 1.22). This study therefore reports the beneficial effect of atorvastatin for the treatment of SCI-related pathology and disability.
Optofluidic device for label-free cell classification from whole blood (2012)

We demonstrated a unique optofluidic lab-on-a-chip device that can measure optically encoded forward scattering signals. From the design of the spatial pattern, we can measure the position and velocity of each cell in the flow and generate a 2-D cell distribution plot over the cross section of the channel. Moreover, we have demonstrated that the cell distribution is highly sensitive to its size and stiffness. The latter is an important biomarker for cell classification and our method offers a simple and unequivocal method to classify cells by their size and stiffness. We have proved the concept using live and fixed HeLa cells. Due to the stiffness and size difference of neutrophils compared to other types of white blood cells, we have demonstrated detection of neutrophils from other blood cells. Finally, we have performed the test using 5 μL of human blood. In a greatly simplified blood preparation process, skipping the usual steps of anticoagulation, centrifuge, antibody labelling or staining, filtering, etc., we have demonstrated that our device and detection principle can count neutrophils in whole human blood. Our system is compact, inexpensive and simple to fabricate and operate, having a commodity laser diode and a Si PIN photoreceiver as the main pieces of hardware. Although the results are still preliminary, the studies indicate that this optofluidic device holds promise to be a point-of-care and home care device to measure neutrophil concentration, which is the key indicator of the immune functions for cancer patients undergoing chemotherapy.
Identification and Characterization of aβ1,3-Glucosyltransferase That Synthesizes the Glc-β1,3-Fuc Disaccharide on Thrombospondin Type 1 Repeats (2006)

Thrombospondin type 1 repeats (TSRs) are biologically important domains of extracellular proteins. They are modified with a unique Glcbeta1,3Fucalpha1-O-linked disaccharide on either serine or threonine residues. Here we identify the putative glycosyltransferase, B3GTL, as the beta1,3-glucosyltransferase involved in the biosynthesis of this disaccharide. This enzyme is conserved from Caenorhabditis elegans to man and shares 28% sequence identity with Fringe, the beta1,3-N-acetylglucosaminyltransferase that modifies O-linked fucosyl residues in proteins containing epidermal growth factor-like domains, such as Notch. beta1,3-Glucosyltransferase glucosylates properly folded TSR-fucose but not fucosylated epidermal growth factor-like domain or the non-fucosylated modules. Specifically, the glucose is added in a beta1,3-linkage to the fucose in TSR. The activity profiles of beta1,3-glucosyltransferase and protein O-fucosyltransferase 2, the enzyme that carries out the first step in TSR O-fucosylation, superimpose in endoplasmic reticulum subfractions obtained by density gradient centrifugation. Both enzymes are soluble proteins that efficiently modify properly folded TSR modules. The identification of the beta1,3-glucosyltransferase gene allows us to manipulate the formation of the rare Glcbeta1,3Fucalpha1 structure to investigate its biological function.
Isolation and Functional Analysis of Human Neutrophils (2015)

This unit describes the isolation of human polymorphonuclear neutrophils (PMN) from blood using dextran sedimentation and Percoll or Ficoll-Paque density gradients. Assays of neutrophil functions including respiratory burst activation, phagocytosis, and microbial killing are also described.
pH-and thermo-sensitive pluronic/poly(acrylic acid)<i>in situ</i>hydrogels for sustained release of an anticancer drug (2012)

In this study, we developed oral in situ gelling formulations composed of pluronic (Plu) and polyacrylic acid (PAA) for the delivery of an anticancer drug, epirubicin (Epi). We investigated various Plu/PAA/Epi formulations for their physicochemical properties and in vitro permeation and accumulation, as well as for in vivo pharmacokinetic and antitumor efficacy. A scanning electron microscopic (SEM) image of Plu 14%/PAA 0.75%/Epi hydrogel showed a sponge-like structure. This formulation has suitable gelation time, water content, bioadhesive force, structural stability, and a high permeation percentage of Epi, with sustained drug release characteristics for 96 h. This hydrogel was retained at the end of the ileum near the colon of Sprague-Dawley (SD) rats for at least 12 h. An in vivo pharmacokinetic study using SD rats showed that after oral administration in this formulation, Epi had prolonged half-life, greater area under the curve, and higher relative bioavailability than in an oral Epi solution. In vivo tumor growth inhibition of Epi in this formulation was more pronounced compared with oral Epi and intravenous Epi solutions in CT-26 mouse colon adenocarcinoma bearing Balb/c mice. This study highlights the advantages of using oral in situ temperature- and pH-sensitive hydrogels for future cancer therapy.
Novi Sad CTM maize hybrids (2006)

In the last several years Research Institute of Field and Vegetable Crops from Novi Sad was working on development of CTM technology (Cycloxydim Tolerant Maize). The trait of interest has been introduced in parental lines of commercial single cross hybrids. Improved genotypes does not differ in basic agronomic traits from their conventional counterparts. The only one difference between them is tolerance to Cycloxydim.
CD8 T Cell-Mediated Killing of <i>Cryptococcus neoformans</i> Requires Granulysin and Is Dependent on CD4 T Cells and IL-15 (2002)

Granulysin is located in the acidic granules of cytotoxic T cells. Although the purified protein has antimicrobial activity against a broad spectrum of microbial pathogens, direct evidence for granulysin-mediated cytotoxicity has heretofore been lacking. Studies were performed to examine the regulation and activity of granulysin expressed by CD8 T cells using Cryptococcus neoformans, which is one of the most common opportunistic pathogens of AIDS patients. IL-15-activated CD8 T cells acquired anticryptococcal activity, which correlated with the up-regulation of granulysin. When granules containing granulysin were depleted using SrCl(2,) or when the gene was silenced using 21-nt small interfering RNA duplexes, the antifungal effect of CD8 T cells was abrogated. Concanamycin A and EGTA did not affect the antifungal effect, suggesting that the activity of granulysin was perforin independent. Following stimulation by the C. neoformans mitogen, CD8 T cells expressed granulysin and acquired antifungal activity. This activity required CD4 T cells and was dependent upon accessory cells. Furthermore, IL-15 was both necessary and sufficient for granulysin up-regulation in CD8 T cells. These observations are most consistent with a mechanism whereby C. neoformans mitogen is presented to CD4 T cells, which in turn activate accessory cells. The resultant IL-15 activates CD8 T cells to express granulysin, which is responsible for antifungal activity.
Design of rotational dielectric dome with linear array feed for wide‐angle multibeam antenna applications (2007)

Abstract This paper proposes a method for design of the shape and thickness of a dielectric dome by optimization, aiming at achieving multibeam emission with a uniform high gain for a wide range of angles. The dielectric dome has the features that it does not require a tremendous number of elements, as in the constrained lens, and that excellent multibeam characteristics can be realized over a wider range of angles than in the conventional dielectric lens. These features are demonstrated through an example of the design of a dielectric dome in which a decrease in gain is avoided over a wide range of angles up to 70 ° . The validity of the proposed method is verified by numerical analysis, and also by measurement and evaluation of the radiation pattern of the constructed dielectric dome antenna in the Ka band. © 2007 Wiley Periodicals, Inc. Electron Comm Jpn Pt 2, 90(5): 49– 57, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/ecjb.20254
A security model for military message systems: retrospective (2005)

We favor an approach to building secure systems that includes an application-based security model. An instance of such a model and its formalization have been presented. Important aspects of the model are: (1) because it is framed in terms of operations and data objects that the user sees, the model captures the system's security requirements in a way that is understandable to users; (2) the model defines a hierarchy of entities and references; access to an entity can be controlled based on the path used to refer to it; (3) because the model avoids specifying implementation strategies, software developers are free to choose the most effective implementation; (4) the model and its formalization provide a basis for certifiers to assess the security of the system as a whole. Simplicity and clarity in the model's statement have been primary goals. The model's statement does not, however, disguise the complexity that is inherent in the application. In this respect, we have striven for a model that is as simple as possible but stops short of distorting the user's view of the system. The work reported demonstrates the feasibility of defining an application-based security model informally and subsequently formalizing it.
A Critical Analysis of New Molecular Targets and Strategies for Drug Developments in Alzheimers Disease (2003)

Alzheimer's disease (AD), a progressive, degenerative disorder of the brain, is believed to be the most common cause of dementia amongst the elderly. AD is characterized by the presence of amyloid deposits and neurofibrillary tangles in the brain of afflicted individuals. AD is associated with a loss of the presynaptic markers of the cholinergic system in the brain areas related to memory and learning. AD appears to have a heterogeneous etiology with a large percentage termed sporadic AD arising from unknown causes and a smaller fraction of early onset familial AD (FAD) caused by mutations in one of several genes, such as the beta-amyloid precursor protein (APP) and presenilins (PS1, PS2). These proteins along with tau, secretases, such as beta-amyloid cleaving enzyme (BACE), and apolipoprotein E play important roles in the pathology of AD. On therapeutic fronts, there is significant research underway in the development of new inhibitors for BACE, PS-1 and gamma-secretase as targets for treatment of AD. There is also a remarkable advancement in understanding the function of cholinesterase (ChE) in the brain and the use of ChE-inhibitors in AD. A new generation of acetyl- and butyryl cholinesterase inhibitors is being studied and tested in human clinical trials for AD. The development of vaccination strategies, anti-inflammatory agents, cholesterol-lowering agents, anti-oxidants and hormone therapy are examples of new approaches for treating or slowing the progression of AD. In addition, nutritional, genetic and environmental factors highlight more effective preventive strategies for AD. Developments of early diagnostic tools and of quantitative markers are critical to better follow the course of the disease and to evaluate different therapeutic strategies. In this review, we attempt to critically examine recent trends in AD research from molecular, genetic to clinical areas. We discuss various neurobiological mechanisms that provide the basis of new targets for AD drug development. All these current research efforts should lead to a deeper understanding of the pathobiochemical processes that occur in the AD brain in order to effectively diagnose and prevent their occurrence.
Can dataflow subsume von Neumann computing? (1989)

We explore the question: “What can a von Neumann processor borrow from dataflow to make it more suitable for a multiprocessor?” Starting with a simple, “RISC-like” instruction set, we show how to change the underlying processor organization to make it multithreaded. Then, we extend it with three instructions that give it a fine-grained, dataflow capability. We call the result P-RISC, for “Parallel RISC.” Finally, we discuss memory support for such multiprocessors. We compare our approach to existing MIMD machines and to other dataflow machines.
Estimation of image noise variance (1999)

A novel algorithm for estimating the noise variance of an image is presented. The image is assumed to be corrupted by Gaussian distributed noise. The algorithm estimates the noise variance in three steps. At first the noisy image is filtered by a horizontal and a vertical difference operator to suppress the influence of the (unknown) original image. In a second step a histogram of local signal variances is computed. Finally a statistical evaluation of the histogram provides the desired estimation value. For a comparison with several previously published estimation methods an ensemble of 128 natural and artificial test images is used. It is shown that with the novel algorithm more accurate results can be achieved.
A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab (2016)

Excess blood vessel growth contributes to the pathology of metastatic cancers and age-related retinopathies. Despite development of improved treatments, these conditions are associated with high economic costs and drug resistance. Bevacizumab (Avastin®), a monoclonal antibody against vascular endothelial growth factor (VEGF), is used clinically to treat certain types of metastatic cancers. Unfortunately, many patients do not respond or inevitably become resistant to bevacizumab, highlighting the need for more effective antiangiogenic drugs with novel mechanisms of action. Previous studies discovered quininib, an antiangiogenic small molecule antagonist of cysteinyl leukotriene receptors 1 and 2 (CysLT<sub>1</sub> and CysLT<sub>2</sub>). Here, we screened a series of quininib analogues and identified a more potent antiangiogenic novel chemical entity (IUPAC name (<i>E</i>)-2-(2-quinolin-2-yl-vinyl)-benzene-1,4-diol HCl) hereafter designated Q8. Q8 inhibits developmental angiogenesis in Tg(<i>fli1</i>:EGFP) zebrafish and inhibits human microvascular endothelial cell (HMEC-1) proliferation, tubule formation, and migration. Q8 elicits antiangiogenic effects in a VEGF-independent <i>in vitro</i> model of angiogenesis and exerts an additive antiangiogenic response with the anti-VEGF biologic bevacizumab. Cell-based receptor binding assays confirm that Q8 is a CysLT<sub>1</sub> antagonist and is sufficient to reduce cellular levels of NF-κB and calpain-2 and secreted levels of the proangiogenic proteins intercellular adhesion molecule-1, vascular cell adhesion protein-1, and VEGF. Distinct reductions of VEGF by bevacizumab explain the additive antiangiogenic effects observed in combination with Q8. In summary, Q8 is a more effective antiangiogenic drug compared with quininib. The VEGF-independent activity coupled with the additive antiangiogenic response observed in combination with bevacizumab demonstrates that Q8 offers an alternative therapeutic strategy to combat resistance associated with conventional anti-VEGF therapies.
An extension of a CACSD package for network analysis: Metanet (2002)

This paper describes Metanet, a software package for graph and network analysis. It is an extension of /spl Psi/lab, a CACSD package for automatic control which provides the user with a comprehensive language and interpreter for manipulating graph objects. Metanet manages a library of Fortran and C programs encoding algorithms for solving classical graph problems and minimal cost flow network problems. It can be seen as a specific toolbox of /spl Psi/lab. The other main feature is its specific graphical editor which allows easy creation and modification of graphs. Tools are given to randomly generate new networks for algorithm testing. Like /spl Psi/lab, Metanet is an open system where users can add their own programs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Study of Female Anxiety in Hotel du Lac from the Perspective of Power Theory (2023)

The Hotel du Lac has long been a hub for literary research. However, less attention has been paid to the various sorts of female anxiety that appear in the novel. Therefore, this study employs Foucault's power theory to examine feminine anxiety in the book on the basis of literature research and detailed reading. Three distinct forms of anxiety in Hotel du Lac are covered in this essay. One is the stress experienced by married women. Mrs. Pusey and Monica struggled with reproductive issues and body attractiveness, catering to their husband's preferences and requirements. While the loneliness Edith's mother experienced between cultures contributed to her uneasiness in addition to her unhappy marriage. Jennifer's worry as a daughter and an unmarried lady is the second major anxiety in the novel. The last anxiety relates to Edith’s appearance, single status, and writing. However, the modest attire she insisted on, her desire for romantic love, and her insistence on making up her own stories were how she ultimately fought the male disciplinary power. According to the article's meticulous analysis of the various anxieties, the patriarchal society's power structure is found to be the main cause of women's discomfort. In order to overcome their identity concern, women are encouraged to choose an appropriate vocation and develop independent female awareness.
Initial Infarct location of Acute Stroke in Middle Cerebral Artery Circulation and Its Clinical Outcome using modified rank in scale (2023)

Abstract Introduction: Functional outcome after ischemic stroke is influenced by a variety of factors such as injured brain regions, extend and volume of the infarct. This study aim to correlate the infarct location and functional outcome of the patient. Materials and Method: This is a Prospective study done at MES Medical College, between December 2020 to June 2022, total 44 patients were admitted and taken MRI with a diagnosis of acute middle circulation ischemic stroke within 48 hours of symptom onset. Location of infarct is correlated with clinical outcome using a modified Rankin score taken at 45 days follow up. Results: Most of the infarct were located in the right hemisphere. A considerably high impact on functional outcome was found at the insula and surrounding opercular cortex.
Bicyclic nucleosides; stereoselective dihydroxylation and 2′-deoxygenationElectronic supplementary information (ESI) available: 13C NMR spectra for compounds 7, 8 and 17 as well as 1H NMR data spectra for compounds 5, 11 and 18. See http://www.rsc.org/suppdata/ob/b2/b210439c/ (2003)

A series of polyhydroxylated bicyclic nucleoside derivatives is approached applying stereoselective dihydroxylation reactions. Three out of four isomeric and protected products were obtained after the stereoselectivity of dihydroxylation has been completely inverted comparing a bicyclic nucleoside with a tricyclic furanose substrate. A corresponding 2'-deoxynucleoside derivative has been obtained after an optimized deoxygenation procedure.
[Restorative effect of quercetin on subcellular distribution of daunorubicin in multidrug resistant leukemia cell lines K562/ADM and HL-60/ADM]. (2004)

quercetin could be a candidate of effective multidrug resistance-reversing agent in leukemia chemotherapy.
Cells and Holograms – Holograms and Digital Holographic Microscopy as a Tool to Study the Morphology of Living Cells (2013)

Cells and Holograms – Holograms and Digital Holographic Microscopy as a Tool to Study the Morphology of Living Cells