gebhart/patrepeval huggingface dataset:
Mutual regulation of EBV LMP1 and CD99 in the pathogenesis of EBV‐associated Hodgkin lymphomas (2008)

ABSTRACT Despite considerable progress over the last decade, Hodgkin lymphoma (HL) remains a malignant tumor of unknown pathogenesis. The role of Epstein‐Barr virus (EBV) and the activation of transcription factor NF‐κB have been noted in the tumorigenesis of classic HL. Recently, a distinctive interaction between CD99 and the EBV viral latent membrane protein 1 (LMP1) was observed in the process of the malignant transformation of EBV‐infected B cells. It was previously reported that CD99 expression is negatively regulated by LMP1, subsequently generating cells with Hodgkin and Reed‐Sternberg (HRS) cell phenotype. Interestingly, several pieces of evidence have been recently revealed the presence of mutual regulation between CD99 and LMP1, which may assist in determining HL pathogenesis. In this review, the roles of CD99 and LMP1 in the generation of the HRS cell, a tumor cell of HL, will be discussed. We also suggest that CD99 and LMP1 interaction in an in vivo system may provide new insight into the understanding of the molecular mechanism of HL.
Mixed‐Signal Circuit Design (2004)

Chapter 4 provides a brief overview of the issues facing mixed signal circuits and provides guidance for avoiding some of the pitfalls associated with designing circuits on these advanced processes. While detailed circuit descriptions are not provided, some general guidelines and options are presented through the use of examples to help designers to understand the trade-offs that need to be considered to ensure a functional design is implemented. Process issues that affect the performance of analog circuits are discussed at length. Integration issues within a larger digital chip, such as noise coupling, power busing, supply decoupling, and thermal issues, are also discussed.
Immortal DB (2005)

Immortal DB builds transaction time database support into the SQL Server engine, not in middleware. Transaction time databases retain and provide access to prior states of a database. An update "inserts" a new record while preserving the old version. The system supports as of queries returning records current at the specified time. It also supports snapshot isolation concurrency control. Versions are stamped with the times of their updating transactions. The timestamp order agrees with transaction serialization order. Lazy timestamping propagates timestamps to all updates of a transaction after commit. All versions are kept in an integrated storage structure, with historical versions initially stored with current data. Time-splits of pages permit large histories to be maintained, and enable time based indexing. We demonstrate Immortal DB with a moving objects application that tracks cars in the Seattle area.
Shear rheological properties of acrylic copolymers and terpolymers suitable for potentially melt processable carbon fiber precursors (2004)

Abstract In an effort to generate melt processable polyacrylonitrile (PAN) precursor fibers suitable for conversion to carbon fibers, an acrylonitrile/methyl acrylate (AN/MA) copolymer and two acrylonitrile/methyl acrylate/acryloyl benzophenone (AN/MA/ABP) terpolymers were synthesized at molar ratios of 85/15 and 85/14/1, respectively. The termonomer (ABP) was incorporated to accelerate crosslinking via UV irradiation, which serves to prevent relaxation of orientation and flow as the temperature of the fiber is raised during thermooxidative stabilization. Two molecular weights of the terpolymer and one molecular weight of the copolymer were studied to determine the effect of the termonomer, and the effect of molecular weight (MW), on the steady shear viscosity (η) and magnitude of the complex viscosity (η*). A higher rate of increase of η as a function of time was observed for the high MW terpolymer relative to that of the copolymer over the temperature range used. Using a temperature sweep and monitoring levels of η*, a minimum was observed at lower temperatures for both terpolymers. These results suggest that copolymerization with ABP significantly increased the thermally induced kinetics of crosslinking. Comparison of the η and η* data for the low and high MW terpolymers suggested that molecular weight also significantly reduced the melt stability (increased the kinetics of crosslinking). A chemorhelogical correlation was then used to quantify the effects of the termonomer and of molecular weight on the kinetics of crosslinking of the AN terpolymers. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 2856–2865, 2004
Early Osteoinduction in Rats Is Not Altered by Fibrin Sealant (1993)

The angiogenic and fibrogenic activities of fibrin sealant (Tisseel) suggest that it could enhance osteoinductivity during the first days after implantation. To test this hypothesis, the osteoinductivity of sealed and unsealed bone matrix gelatin was tested by implantation into rat abdominal wall muscle pouches for two to ten days. A sponge of collagen with or without fibrin sealant was used for control. Alkaline phosphatase (ALPase) was employed to quantify osteoinduction, and myeloperoxidase (MPO) was used to determine the inflammatory reaction. Plain histologic analysis of bone matrix gelatin implants at Days 2, 4, and 10 did not demonstrate any significant differences between sealed and nonsealed implants. Histologic analysis at Day 21 confirmed the osteoinductivity of the implant. The combination of bone matrix gelatin and fibrin sealant induced an early significant increase in ALPase activity, which could be interpreted as early induction of histologically undetectable osteogenesis. A simultaneous increase in the level of MPO suggested that the bone matrix gelatin/fibrin sealant-induced ALPase reaction might be caused by an inflammatory process, but neutrophil counting did not correlate to the MPO data. Morphometry, however, seems to be insufficient to assay a heterogenous histologic distribution of singular cells. It is proposed that the ALP/MPO ratio may be used as an inflammation-independent marker of osteogenesis. This study does not support the notion of an osteoinductive potency of fibrin sealant per se; however, it is clear that fibrin sealant does not impair bone matrix gelatin-dependent osteoinduction.
Emerging technologies in NDT : proceedings of the 2nd International Conference on Emerging Technologies in NDT, Athens, Greece, 24-26 May 1999 (2000)

This volume contains the papers presented at the 2nd International Conference entitled: Emerging Technologies in which was held in Athens, Greece, May 24-26, 1999. This work covers frequently used non-destructive testing methods and introduces innovative ideas in the field. The title also focuses on visual and optical inspection, acoustic emission and ultrasonics as well as a range of other closely related topics. More than 50 papers were presented at the conferecne by invited and distinguished researchers from all over the world. This volume forms a valuable record of important contributions to the relevant literature. It contains not only the most up-to-date technology developments but provides also information regarding emerging NDT techniques/technologies and their potential applications in the field. The book covers frequently used NDT methods and introduces new and innovative ideas. Focussing on visual and optical inspection, acoustic emission, ultrasonics, nonlinear ultrasonics, infrared methods, X-ray radiography, special techniques, material characterisation, NDT of civil engineering structures, inspection of pipes and reliability and validation this volume will be a great boon to engineers, researchers, quality control managers, as well as teachers and graduate students in the field.
Electrochemical Behavior of the Li<sup>+</sup>/Li Couple and Stability of Lithium Deposits in Tri‐1‐Butylmethylammonium Bis((Trifluoromethyl)Sulfonyl)Imide Room Temperature Ionic Liquid (2006)

Abstract The electrochemical behavior of the Li + /Li couple was studied at polycrystalline tungsten, platinum, copper and aluminum electrodes in tri‐1‐butylmethylammonium bis((trifluoromethyl)sulfonyl)imide ionic liquid mixed with a little propylene carbonate at 30 °C. Lithium cations were introduced into the ionic liquid by dissolution of lithium bis((trifluoromethyl)sulfonyl)imide which is highly soluble in ionic liquid. Propylene carbonate was used to reduce the viscosity of this ionic liquid in order to enhance the mass transfer and to additionally improve the stability of lithium deposits. At the tungsten and copper electrodes, the cyclic voltammetric behavior of a Li + /Li couple is a quasi‐reversible reaction. At the platinum electrode, the behavior becomes very complicated because of the alloy formation. Coulombic efficiency was used to evaluate the stability of lithium deposits at each electrode. The aluminum electrode showed the best efficiency due to the formation of Li‐Al alloy. However, lowest efficiency was obtained at the platinum electrode because of the low redox reversibility of the lithium in the Li‐Pt alloy. The diffusion coefficient of lithium cation in this solution was 1.0 ± 0.1 × 10 −;7 cm 2 s −;1 as determined by chronopotentiometry. The best coulombic efficiency obtained at the Al electrode is 97% but dropped to about 90% after 12 hours. The self‐discharge current of the lithium deposits at the Al electrode was 0.4 μA/cm 2 during the experimental period.
Cross‐talk and sensitization of bladder afferent nerves (2009)

The coordination of pelvic physiologic function requires complex integrative sensory pathways that may converge both peripherally and/or centrally. Following a focal, acute irritative or infectious pelvic insult, these same afferent pathways may produce generalized pelvic sensitization or cross-sensitization as we show bi-directionally for the bladder and bowel in an animal model. Single unit bladder afferent recordings following intracolonic irritation reveal direct sensitization to both chemical and mechanical stimuli that's dependent upon both intact bladder sensory (C-fiber) innervation and neuropeptide content. Concurrent mastocytosis (preponderantly neurogenic) likely plays a role in long-term pelvic organ sensitization via the release of nociceptive and afferent-modulating molecules. Prolonged pelvic sensitization as mediated by these convergent and antidromic reflexive pathway may likewise lead to chronic pelvic pain and thus the overlap of chronic pelvic pain disorders.
How Does Sodium Lauryl Sulfate Alter the Skin Barrier Function in Man? A Multiparametric Approach (1993)

The effects of topically applied sodium lauryl sulfate were studied in vivo, in man, through noninvasive methods and compared with those obtained in vitro, using human stratum corneum as a model. The results show that the very marked increase of transepidermal water loss obtained in vivo cannot be related to any removal of epidermal lipids. The most likely explanation of our findings lies in the hyperhydration of stratum corneum consecutive to the inflammation process and a possible disorganization of the lipid bilayers.
Large‐scale mapping of human protein–protein interactions by mass spectrometry (2007)

Mapping protein-protein interactions is an invaluable tool for understanding protein function. Here, we report the first large-scale study of protein-protein interactions in human cells using a mass spectrometry-based approach. The study maps protein interactions for 338 bait proteins that were selected based on known or suspected disease and functional associations. Large-scale immunoprecipitation of Flag-tagged versions of these proteins followed by LC-ESI-MS/MS analysis resulted in the identification of 24,540 potential protein interactions. False positives and redundant hits were filtered out using empirical criteria and a calculated interaction confidence score, producing a data set of 6463 interactions between 2235 distinct proteins. This data set was further cross-validated using previously published and predicted human protein interactions. In-depth mining of the data set shows that it represents a valuable source of novel protein-protein interactions with relevance to human diseases. In addition, via our preliminary analysis, we report many novel protein interactions and pathway associations.
Handbook of human factors and ergonomics (2023)

"Handbook of human factors and ergonomics." International Journal of Occupational Safety and Ergonomics, ahead-of-print(ahead-of-print), p. 1
Characterization and partial purification of the human receptor for the heat‐stable enterotoxin (1994)

The receptor for the Escherichia coli heat-stable enterotoxin has been characterized and partially purified from the T84 human colonic cell line. Using a novel mutant heat-stable enterotoxin peptide as a radioligand (the C-terminal tyrosine residue is replaced by phenylalanine in the mutant), a single class of high-affinity receptor sites was detected in T84 cells, with a Kd of 0.1 nM, similar in affinity to the receptor described in human intestinal tissue. The receptor was solubilised from T84 cell membranes and affinity cross-linking of the solubilised preparation indicated that a single species of M(r) 160,000 served as the receptor. Freshly solubilised preparations of the receptor retained heat-stable enterotoxin-activable guanylyl cyclase activity. Purification of the receptor was achieved through sequential affinity chromatography on GTP--epoxy-Sepharose and wheat-germ-agglutinin columns resulting in purification of the receptor by 3000 fold. The heat-stable enterotoxin-binding characteristics of the receptor were unchanged during the purification and silver staining of the purified receptor preparation indicated a band of M(r) 160,000, which was specifically cross-linked to the 125I-labeled mutant peptide. The purified receptor retained guanylyl cyclase activity, but the activity was not stimulated on addition of human heat-stable enterotoxin, suggesting that accessory structural factors may be involved in the activation of the guanylyl cyclase/receptor.
Bacterial Self-Resistance to the Natural Proteasome Inhibitor Salinosporamide A (2011)

Proteasome inhibitors have recently emerged as a therapeutic strategy in cancer chemotherapy, but susceptibility to drug resistance limits their efficacy. The marine actinobacterium Salinispora tropica produces salinosporamide A (NPI-0052, marizomib), a potent proteasome inhibitor and promising clinical agent in the treatment of multiple myeloma. Actinobacteria also possess 20S proteasome machinery, raising the question of self-resistance. We identified a redundant proteasome β-subunit, SalI, encoded within the salinosporamide biosynthetic gene cluster and biochemically characterized the SalI proteasome complex. The SalI β-subunit has an altered substrate specificity profile, 30-fold resistance to salinosporamide A, and cross-resistance to the FDA-approved proteasome inhibitor bortezomib. An A49V mutation in SalI correlates to clinical bortezomib resistance from a human proteasome β5-subunit A49T mutation, suggesting that intrinsic resistance to natural proteasome inhibitors may predict clinical outcomes.
Mixer linearisation for software defined radio applications (2003)

The inherent non-linearity of mixers is particularly acute in broadband receiver design for software defined radio (SDR) applications. Here, the receiver frontend 'sees' not only the wanted channel, but also a number of nearby signals. A conventional mixer will downconvert all of these received channels to IF, thus adding inband interband interference to the wanted channel. In this paper, known mixer linearisation schemes are explained and a new technique using frequency retranslation within a linearised mixer architecture is presented. Two-tone-test results from a prototype offered 33 dB reduction in the distortion products and 22 dB suppression of adjacent channel interference (ACI) for a /spl pi//4-DQPSK modulated carrier. A theoretical analysis is also carried out to demonstrate the amplitude and phase matching requirements of the technique.
Moving through three paradigms, yet remaining the same thinker (2006)

The author reflects on his scientific and professional career as it developed over 40 years. Partly as an autobiographical sketch, he describes three phases, each guided by a specific paradigm: individual differences, narrative, and dialogical. Looking back at the different phases, the author emphasizes the non-linear nature of his development, in which the preceding phases merged into the next one, resulting in complex combinations of old and new elements.
New three-gamma-curves-integrated VA LCD design for excellent image quality and enhanced transmittance (2016)

Compared with the in-plane switching (IPS) mode of the liquid crystal display (LCD), the vertical-alignment (VA) LCD mode provides an excellent contrast ratio and a fast response time, but it still has a relative weakness: image quality deterioration as a function of the viewing direction. In the VA mode, the pixel division method, in which two different gamma curves from the divided pixels are integrated, is generally used to improve the off-axis image quality. Reported herein is the new VA mode for enhancing the off-axis image without decreasing the transmittance. The pixels divided into 12 domains instead of 8 using double electrode layers produce three different gamma curves from the high, middle, and low pixels, which are combined and enhance the image quality. In this pixel structure, the middle pixels are formed by two electrode layers and produce the third gamma curve. The new design of the VA mode shows the best off-axis image quality in the VA mode, which is the most comparable with that in the IPS mode, even with the organic light-emitting diode, and will provide a solution for the heavy competition in the ultrahigh-definition (UHD) and large-LCD-TV-panel market in the very near future.
Controlling flexural waves using subwavelength perfect absorbers : application to Acoustic Black Holes (2019)

The vibration control adapted to light structures is a scientific and technological challenge due toincreasingly stringent economic and ecological standards. Meanwhile, recent studies in audible acoustics havefocused on broadband wave absorption at low frequencies by means of subwavelength perfect absorbers. Suchmetamaterials can totally absorb the energy of an incident wave. The generalisation of this method for applicationsin elastodynamics could be of great interest for the vibration control of light structures.This thesis aims at adapting the perfect absorption problem for flexural waves in 1D and 2D systems with localresonators using the critical coupling condition. A study of 1D systems with simple geometries is first proposed. Thisprovides methods to design simple resonators for an effective absorption of flexural waves. The 1D systems thenbecome more complex by studying the critical coupling of 1D Acoustic Black Holes (ABH). The ABH effect is theninterpreted using the concept of critical coupling, and key features for future optimisation procedures of ABHs arepresented. The critical coupling condition is then extended to 2D systems. The perfect absorption by the firstaxisymmetric mode of a circular resonator inserted in a thin plate is analysed. Multiple scattering by an array ofcircular resonators inserted in an infinite or semi-infinite 2D thin plate, called metaplate, is also considered to getclose to practical applications. Through this thesis, analytical models, numerical simulations and experiments areshown to validate the physical behaviour of the systems presented.
Effects of parameter variations on negative effective constitutive parameters of non-metallic metamaterials (2013)

Analytical expressions describing the variability of effective constitutive parameters of non-metallic metamaterials, as a function of the constituent geometric and material parameters and their variations, have been developed from the total differential of Clausius-Mossotti expressions (using Mie dipole polarizabilities) for the effective (bulk) constitutive parameters of the metamaterial. In practice, these expressions are important for estimating the performance of a metamaterial with particular variations in the parameters of its constituents that arise during the fabrication process, and can be used to guard against extinction of desired double negative (DNG) behavior. With the derived expressions, the effects of parameter variations on effective constitutive parameters of non-metallic metamaterials have been analyzed for three types of metamaterials: (i) cubic arrays of identical magnetodielectric spheres; (ii) cubic arrays of dielectric spheres with equal radius but two different permittivities; and (iii) cubic arrays of dielectric spheres with equal permittivity but two different radii. These effects are evaluated in terms of the calculated variations in values of the effective constitutive parameters of the metamaterial in the vicinity of the DNG or single negative (SNG) band for particular geometric and material parameters and their variations. Results show that variation in the following parameters impacts DNG bandwidth. Listed in order from greatest to least influence: (i) sphere radius; (ii) sphere permittivity and permeability; (iii) lattice constant of the array; and (iv) the constitutive parameters of the array medium, all impact the width of the achievable DNG band. For particular cases studied here, results also show that the DNG behavior may be extinguished if there are 0.78%, 0.016%, and 0.016% variations in all parameters of metamaterial types (i), (ii), and (iii), respectively, as defined above. For the design of non-metallic metamaterials with inclusions, having arbitrary material parameters, in either periodic or random arrangement, the presented results can give a qualitative guide on the level of fabrication tolerances that should be achieved in order to observe the predicted SNG or DNG behavior experimentally.
A Comprehensive Study and Comparison of Core Technologies for MPEG 3-D Point Cloud Compression (2019)

Point cloud based 3D visual representation is becoming popular due to its ability to exhibit the real world in a more comprehensive and immersive way. However, under a limited network bandwidth, it is very challenging to communicate this kind of media due to its huge data volume. Therefore, the MPEG have launched the standardization for point cloud compression (PCC), and proposed three model categories, i.e., TMC1, TMC2, and TMC3. Because the 3D geometry compression methods of TMC1 and TMC3 are similar, TMC1 and TMC3 are further merged into a new platform namely TMC13. In this paper, we first introduce some basic technologies that are usually used in 3D point cloud compression, then review the encoder architectures of these test models in detail, and finally analyze their rate distortion performance as well as complexity quantitatively for different cases (i.e., lossless geometry and lossless color, lossless geometry and lossy color, lossy geometry and lossy color) by using 16 benchmark 3D point clouds that are recommended by MPEG. Experimental results demonstrate that the coding efficiency of TMC2 is the best on average (especially for lossy geometry and lossy color compression) for dense point clouds while TMC13 achieves the optimal coding performance for sparse and noisy point clouds with lower time complexity.