gebhart/patrepeval huggingface dataset:
A core generator for fully synthesizable and highly parameterizable RISC-cores for system-on-chip designs (2002)

Driven by the rapid advances in semiconductor technology the number of functional units that can be implemented on a single chip is rapidly increasing. This raises the need for programmable but small processor cores to handle control of operation as well as communication and synchronization between the different functional modules on the chip. We have developed a soft core generator for highly parameterizable RISC-cores. The instruction word width can be arbitrarily chosen between 8 and 32 bits. Independent of this, the data-path width can be selected between 8 and 64 bits respectively. DSP-like performance can be achieved with the instantiation of a 64-bit (splittable-) MAC-unit in the data-path. The number of registers is arbitrarily scalable. The resulting cores are generated in RTL-VHDL and are fully synthesizable. Worst-case timing simulation shows 100 MHz achievable clock-speed using a 3LM 0.5 /spl mu/m standard-cell technology. The size of the synthesized cores ranges from 900 gates for a multi-cycle 8 bit core to 10k gates for a 5-stage pipelined 32 bit core with 8 registers. Interfaces and behavioral models are provided for instruction and data memories as well as a runnable VHDL testbench with basic test patterns. As a result, a 16 bit RISC core with instruction and data memories can be implemented on 1 mm/sup 2/ of silicon area in a 0.35 /spl mu/m technology.
Chronic GVHD: a new risk score? (2011)

Chronic GVHD is the leading cause of late nonrelapse morbidity and mortality. It is thus crucial for patient management and counseling to identify patients with low or high chronic GVHD-associated nonrelapse mortality risk.

Chronic graft-versus-host disease (GVHD) is a frequent but highly
Well-conditioned multiple laser Mueller matrix ellipsometer (2008)

We report on the design and performance test of a multiple laser Mueller matrix ellipsometer (MME). The MME is well conditioned due to the integration of the recently reported achromatic 132-deg compensators based on biprisms, in combination with high-quality Glan-Thompson polarizers. The system currently operates between 300 and 2700 nm, without the need to change any optical components except for the detector. Four lasers are employed as light sources (405, 532, 633, and 1570 nm) to test the performance in both reflection and transmission modes. Thus, the system is used to determine the Mueller matrices and associated optical constants of known optical systems: 1. optical rotatory power of D-glucose in solution, 2. reflection of a native oxide c-Si wafer, and 3. the properties of a liquid crystal spatial light modulator. The results show that the system matrices of the MME have condition numbers between the optimal and 2 during operation, resulting in small experimental errors. To the best of our knowledge, there is no other MME reported with such good conditioning over a comparably wide spectral range.
High-Temperature, High-Density Packaging of a 60kW Converter for <200/spl deg/C Embedded Operation (2006)

This paper describes the design of a 60kW, actuator motor drive using high temperature SiC devices. Power JFET devices are selected for high-frequency performance and high density. High-density packaging uses an aluminum conductor, AlN substrate and AlSiC combination to minimize dissimilar interfaces. The forced air-cooled design provides >1.1kW/cu.in.
The efficiency of Color Models layers at Color Images as Cover in text hiding (2023)

The color images are used widely as a cover in hiding of the information. Since the variety of applications of the color image there are several color models of color image. Most color models consist of three layers. The nature of the color mode of the cover plays a main role in determining the robustness and security of hiding algorithm. The objective of this paper tests the layers, components, of the color models of cover color images, to figure out which color layer of each color model is best (less affected) to use as a cover to hide information within each color model in the hiding process. The experiments concentrate on the hiding texts in two positions of each layer, 7th bits and 8th bits (LSB). Mean Square Error (MSE) and Peak Signal to Noise Ratio (PSNR) were used to measure the affected of hidden text in layers. The tests were done on nine colors models: RGB, HSV, HIS, HSL, HSB, YCbCr, La*b*, LUV and CMYK. The results show that some of color models have best layer to hide text such as YCbCr, HSI, CMYK, HSL and LUV . In other color models which have been tested, there is not a distinctive layer. The layer H is the worst because any hiding leaves a clear impact on the cover image.
NMR Structure of the Second Intracellular Loop of the α2A Adrenergic Receptor:  Evidence for a Novel Cytoplasmic Helix<sup>,</sup> (2002)

A major, unresolved question in signal transduction by G protein coupled receptors (GPCRs) is to understand how, at atomic resolution, a GPCR activates a G protein. A step toward answering this question was made with the determination of the high-resolution structure of rhodopsin; we now know the intramolecular interactions that characterize the resting conformation of a GPCR. To what degree does this structure represent a structural paradigm for other GPCRs, especially at the cytoplasmic surface where GPCR-G protein interaction occurs and where the sequence homology is low among GPCRs? To address this question, we performed NMR studies on approximately 35-residue-long peptides including the critical second intracellular loop (i2) of the alpha 2A adrenergic receptor (AR) and of rhodopsin. To stabilize the secondary structure of the peptide termini, 4-12 residues from the adjacent transmembrane helices were included and structures determined in dodecylphosphocholine micelles. We also characterized the effects on an alpha 2A AR peptide of a D130I mutation in the conserved DRY motif. Our results show that in contrast to the L-shaped loop in the i2 of rhodopsin, the i2 of the alpha 2A AR is predominantly helical, supporting the hypothesis that there is structural diversity within GPCR intracellular loops. The D130I mutation subtly modulates the helical structure. The spacing of nonpolar residues in i2 with helical periodicity is a predictor of helical versus loop structure. These data should lead to more accurate models of the intracellular surface of GPCRs and of receptor-mediated G protein activation.
Sensitization of transformed rat fibroblasts to killing by parvovirus minute virus of mice correlates with an increase in viral gene expression (1988)

Cultures of established rat fibroblasts transformed by the avian erythroblastosis virus were more susceptible to the cytopathic effect of the autonomous parvovirus minute virus of mice, prototype strain (MVMp), than were their untransformed homologs. This effect could be ascribed to the presence of a greater fraction of cells that were sensitive to the killing action of MVMp in transformed cultures than in their normal parents. Yet, transformed and normal lines were similarly efficient in virus uptake, DNA amplification, and capsid protein synthesis. In contrast, transformants accumulated 2.5- to 3-fold greater amounts of all three major MVM mRNA species and nonstructural protein than did their normal progenitors. Thus, in this system transformation-associated sensitization of cells to MVMp appears to correlate primarily with an increase in their capacity for the expression of the viral transcription unit which encodes nonstructural proteins and is controlled by the P4 promoter. Consistently, a reporter gene was expressed at a higher level by transformed versus normal cultures, when placed under the control of the MVM P4 promoter. As infectious MVMp was produced in larger amounts by transformed cultures, a late step of the parvoviral cycle, such as synthesis, encapsidation of progeny DNA, or both, was also stimulated in the transformed cells.
Induction of centrosome amplification and chromosome instability in <i>p53</i>‐deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE) (2008)

Benzo[a]pyrene diol epoxide (B[a]PDE), the ultimate carcinogenic metabolite of benzo[a] pyrene, has been implicated in the mutagenesis of the p53 gene involved in smoking-associated lung cancer. To further understand the role of B[a]PDE in lung tumour progression, we investigated its effect on the numerical integrity of centrosomes and chromosome stability in lung cancer cells lacking p53. Exposure of p53-deficient H1299 lung cancer cells to B[a]PDE resulted in S-phase arrest, leading to abnormal centrosome amplification. Analysis of H1299 cells stably expressing fluorescence-tagged centrin (a known centriolar marker) revealed that the centrosome amplification was primarily attributable to excessive centrosome duplication rather than to centriole splitting. Forced expression of POLK DNA polymerase, which has the ability to bypass B[a]PDE-guanine lesions in an error-free manner, suppressed the B[a]PDE-induced centrosome amplification. Fluorescence in situ hybridization analyses with probes specific for chromosomes 2, 3, and 16 revealed that B[a]PDE exposure also led to chromosome instability, which was likely to have resulted from centrosome amplification. We extended these findings to primary lung carcinomas containing non-functional p53, and found a strong association between centrosome amplification and a high level of B[a]PDE-DNA accumulation. Therefore B[a]PDE contributes to neoplasia by inducing centrosome amplification and consequent chromosome destabilization as well as its mutagenic activity.
Characteristics of collagenase-2 from gingival crevicular fluid and peri-implant sulcular fluid in periodontitis and peri-implantitis patients: pilot study (2008)

Peri-implantitis PISF contained higher collagenase-2 levels and activity than GCF from similar deep CP sites. GCF and PISF from severe CP and PI exhibited the highest activation of MMP-8 isoenzymes species (PMN and fibroblast-type).
A Microwave-Pumped XeCl Laser, (1981)

A XeCl* excimer laser excited by 2‐ms‐long, 9.375‐GHz microwave pulses has been constructed. Spontaneous emission times of ∼500 ns have been observed, while the maximum laser pulse length was 100 ns. The laser pulse length appears to be limited by the buildup of a transient loss.
User evaluation of see-through vision for mobile outdoor augmented reality (2008)

We have developed a system built on our mobile AR platform that provides users with see-through vision, allowing visualization of occluded objects textured with real-time video information. We present a user study that evaluates the userpsilas ability to view this information and understand the appearance of an outdoor area occluded by a building while using a mobile AR computer. This understanding was compared against a second group of users who watched video footage of the same outdoor area on a regular computer monitor. The comparison found an increased accuracy in locating specific points from the scene for the outdoor AR participants. The outdoor participants also displayed more accurate results, and showed better speed improvement than the indoor group when viewing more than one video simultaneously.
Fundamentos histográficos em Cenzibra Jacques (2008)

Contextualização dos fundamentos da historiografia republicana no Rio Grande do Sul enfatizando a produção historiográfica de João Cezimbra Jacques e sua defesa da noção de federação e de regionalismo.
Accommodating hybrid retrieval in a comprehensive video database management system (2002)

A comprehensive video retrieval system should be able to accommodate and utilize various (complementary) description data in facilitating effective retrieval. We advocate a hybrid retrieval approach by integrating a query-based (database) mechanism with content-based retrieval (CBR) functions. We describe the VideoMAP/sup +/ architecture, discuss issues related to developing such a comprehensive video database management system, and its specific language mechanism (CAROL/ST with CBR) which provides an improved expressive power than pure query-based or CBR methods currently offer. We also describe an experimental prototype being developed based on a commercial object-oriented toolkit using VC++ and Java.
Capillarity Guided Patterning of Microliquids (2015)

Soft lithography and other techniques have been developed to investigate biological and chemical phenomena as an alternative to photolithography-based patterning methods that have compatibility problems. Here, a simple approach for nonlithographic patterning of liquids and gels inside microchannels is described. Using a design that incorporates strategically placed microstructures inside the channel, microliquids or gels can be spontaneously trapped and patterned when the channel is drained. The ability to form microscale patterns inside microfluidic channels using simple fluid drain motion offers many advantages. This method is geometrically analyzed based on hydrodynamics and verified with simulation and experiments. Various materials (i.e., water, hydrogels, and other liquids) are successfully patterned with complex shapes that are isolated from each other. Multiple cell types are patterned within the gels. Capillarity guided patterning (CGP) is fast, simple, and robust. It is not limited by pattern shape, size, cell type, and material. In a simple three-step process, a 3D cancer model that mimics cell-cell and cell-extracellular matrix interactions is engineered. The simplicity and robustness of the CGP will be attractive for developing novel in vitro models of organ-on-a-chip and other biological experimental platforms amenable to long-term observation of dynamic events using advanced imaging and analytical techniques.
Hard magnetic properties of Sm-Co-Cu-Fe single phase 2-17 bulk samples (1976)

Sm(Co <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.08</inf> Cu <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.13</inf> ) <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">z</inf> alloys were prepared with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7.2 \leq z < 8</tex> . Homogenization heat-treatment yielded single phase 2-17 material for <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">z > 7.2</tex> . For <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">z = 7.8</tex> some of the Co was substituted by Fe. The alloys remained single phase for up to 15 % Co substituted. With further increasing Fe content a Co-Fe phase appears accompanied by a strong decrease of the hard magnetic properties. The compounds were hard magnetic in bulk form with ideal rectangular hysteresis loops. The coercivity could be increased by a factor > 2 with a low temperature heat-treatment. B <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R</inf> values > 11 kG together with <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</inf> H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</inf> values of about 4 kOe were achieved on single crystal samples. The coercivity mechanism in these materials is pinning of Bloch walls.
An intelligent destination recommendation system for tourists (2018)

Choosing a tourist destination from the information available is one of the most complex tasks for tourists when making travel plans, both before and during their travel. With the development of a recommendation system, tourists can select, compare and make decisions almost instantly. This involves the construction of decision models, the ability to predict user preferences, and interpretation of the results. This research aims to develop a Destination Recommendation System (DRS) focusing on the study of machine-learning techniques to improve both technical and practical aspects in DRS. First, to design an effective DRS, an intensive literature review was carried out on published studies of recommendation systems in the tourism domain. Second, the thesis proposes a model-based DRS, involving a two-step filtering feature selection method to remove irrelevant and redundant features and a Decision Tree (DT) classifier to offer interpretability, transparency and efficiency to tourists when they make decisions. To support high scalability, the system is evaluated with a huge body of real-world data collected from a case-study city. Destination choice models were developed and evaluated. Experimental results show that our proposed model-based DRS achieves good performance and can provide personalised recommendations with regard to tourist destinations that are satisfactory to intended users of the system. Third, the thesis proposes an ensemble-based DRS using weight hybrid and cascade hybrid. Three classification algorithms, DT, Support Vector Machines (SVMs) and Multi- Layer Perceptrons (MLPs), were investigated. Experimental results show that the bagging ensemble of MLP classifiers achieved promising results, outperforming baseline learners and other combiners. Lastly, the thesis also proposes an Adaptive, Responsive, Interactive Model-based User Interface (ARIM-UI) for DRS that allows tourists to interact with the recommended results easily. The proposed interface provides adaptive, informative and responsive information to tourists and improves the level of the user experience of the proposed system.
Enhancing Ordering Dynamics in Solvent-Annealed Block Copolymer Films by Lithographic Hard Mask Supports (2014)

We studied solvent-driven ordering dynamics of block copolymer films supported by a densely cross-linked polymer network designed as organic hard mask (HM) for lithographic fabrications. The ordering of microphase-separated domains at low degrees of swelling corresponding to intermediate/strong segregation regimes was found to proceed significantly faster in films on a HM layer as compared to similar block copolymer films on silicon wafers. The 10-fold enhancement of the chain mobility was evident in the dynamics of morphological phase transitions and of related process of terrace formation on a macroscale as well as in the degree of long-range lateral order of nanostructures. The effect is independent of the chemical structure and on the volume composition (cylinder/lamella forming) of the block copolymers. In-situ ellipsometric measurements of the swelling behavior revealed a cumulative increase in 1–3 vol % in solvent uptake by HM-block copolymer bilayer films, so that we suggest other than dilution effect reasons for the observed significant enhancement of the chain mobility in concentrated block copolymer solutions. Another beneficial effect of the HM-support is the suppression of the film dewetting which holds true even for low molecular weight homopolymer polystyrene films at high degrees of swelling. Apart from immediate technological impact in block copolymer-assisted nanolithography, our findings convey novel insight into effects of molecular architecture on polymer–solvent interactions.
Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer’s pathology (2017)

We previously showed that microglial keratan sulfate (KS) was induced in amyotrophic lateral sclerosis. However, the functional roles of the glycan and its synthetic enzyme in neurodegenerative diseases, such as Alzheimer's disease (AD), a progressive disorder, are unclear. In our study, KS modified with sialic acids having a molecular mass of 125-220 kDa and the carbohydrate sulfotransferase GlcNAc6ST1 were up-regulated in the brains of two transgenic mouse models (J20 and Tg2576) and the brains of patients with AD. GlcNAc6ST1-deficient J20 (J20/GlcNAc6ST1<sup>-/-</sup>) mice demonstrated a complete absence of the microglial sialylated KS. J20/GlcNAc6ST1<sup>-/-</sup> primary microglia showed an increased level of amyloid-β phagocytosis and were hyperresponsive to interleukin 4, a potent antiinflammatory cytokine. Moreover, J20/GlcNAc6ST1<sup>-/-</sup> mice manifested reduced cerebral amyloid-β deposition. GlcNAc6ST1-synthesizing sialylated KS thus modulates AD pathology. Inhibition of KS synthesis by targeting GlcNAc6ST1 may therefore be beneficial for controlling AD pathogenesis.
A review of damage detection methods for wind turbine blades (2015)

Wind energy is one of the most important renewable energy sources and many countries are predicted to increase wind energy portion of their whole national energy supply to about twenty percent in the next decade. One potential obstacle in the use of wind turbines to harvest wind energy is the maintenance of the wind turbine blades. The blades are a crucial and costly part of a wind turbine and over their service life can suffer from factors such as material degradation and fatigue, which can limit their effectiveness and safety. Thus, the ability to detect damage in wind turbine blades is of great significance for planning maintenance and continued operation of the wind turbine. This paper presents a review of recent research and development in the field of damage detection for wind turbine blades. Specifically, this paper reviews frequently employed sensors including fiber optic and piezoelectric sensors, and four promising damage detection methods, namely, transmittance function, wave propagation, impedance and vibration based methods. As a note towards the future development trend for wind turbine sensing systems, the necessity for wireless sensing and energy harvesting is briefly presented. Finally, existing problems and promising research efforts for online damage detection of turbine blades are discussed.
Vehicle-to-vehicle and vehicle-to-roadside multi-hop communications for vehicular sensor networks: Simulations and field trial (2013)

Using vehicles as sensors for traffic and environment monitoring is a new paradigm that opens the way to worthwhile applications. Data collected on board are usually delivered through the cellular network, with the consequent overloading risk. This paper focuses on the alternative adoption of short range vehicle-to-vehicle (V2V) and vehicle-to-roadside (V2R) communications, with particular reference to the wireless access in vehicular environment (WAVE)/IEEE802.11p technology. Specifically, we propose and validate, through simulations in a urban scenario, a simple but effective routing algorithm to forward data through V2V and V2R communications. The benefits are quantified in terms of the amount of data that can be transmitted without using cellular resources. Furthermore, we present an urban field trial, deployed to test our proposed multi-hop algorithm, through the adoption of low cost hardware and open source software.
Federated Learning for Mobile Keyboard Prediction (2018)

We train a recurrent neural network language model using a distributed, on-device learning framework called federated learning for the purpose of next-word prediction in a virtual keyboard for smartphones. Server-based training using stochastic gradient descent is compared with training on client devices using the Federated Averaging algorithm. The federated algorithm, which enables training on a higher-quality dataset for this use case, is shown to achieve better prediction recall. This work demonstrates the feasibility and benefit of training language models on client devices without exporting sensitive user data to servers. The federated learning environment gives users greater control over the use of their data and simplifies the task of incorporating privacy by default with distributed training and aggregation across a population of client devices.