gebhart/patrepeval huggingface dataset:
Multiprocessor Control of a Telemanipulator with Optical Proximity Sensors (1984)

The complexity of robotic systems usually necessitates the use of digital computers in their control. When a sensory- feedback control loop is closed around a robot and its com puter system, the real-time flow of data through the computer strongly influences the fidelity of the resultant motion. The purpose of this paper is to identify characteristics of the com puter controller that have the greatest impact on the perform ance of the system and to show, by means of an example, how the performance may be enhanced through the use of digital control techniques. The Stanford Robotic Aid is a computer-assisted telemanip ulator equipped with optical proximity sensors and a multi processor control system. Digital control techniques are used in the study of its application to a surface-following task. Thè dynamic behavior of the manipulator and the computer network is modeled by a set of difference equations. Propor tional sensory feedback is analyzed through use of a root- locus method, and a pole-placement method is used to design a state-feedback controller. The actual behavior of the system in a step-response test is compared to the prediction of the model.
Speech Intelligibility Prediction Using Spectro-Temporal Modulation Analysis (2020)

Spectro-temporal modulations are believed to mediate the analysis of speech sounds in the human primary auditory cortex. Inspired by humans' robustness in comprehending speech in challenging acoustic environments, we propose an intrusive speech intelligibility prediction (SIP) algorithm, wSTMI, for normal-hearing listeners based on spectro-temporal modulation analysis (STMA) of the clean and degraded speech signals. In the STMA, each of 55 modulation frequency channels contributes an intermediate intelligibility measure. A sparse linear model with parameters optimized using Lasso regression results in combining the intermediate measures of 8 of the most salient channels for SIP. In comparison with a suite of 10 SIP algorithms, wSTMI performs consistently well across 13 datasets, which together cover degradation conditions including modulated noise, noise reduction processing, reverberation, near-end listening enhancement, and speech interruption. We show that the optimized parameters of wSTMI may be interpreted in terms of modulation transfer functions of the human auditory system. Thus, the proposed approach offers evidence affirming previous studies of the perceptual characteristics underlying speech signal intelligibility.
Sol-gel encapsulation of cells is not limited to silica : bacteria long-term viability in alumina matrices. (2007)

International audience
Efficacy of Tremacamra, a Soluble Intercellular Adhesion Molecule 1, for Experimental Rhinovirus Infection (1999)

Tremacamra reduced the severity of experimental rhinovirus colds. Whether tremacamra will be useful clinically will require further study.
Integrating Aerial and Street View Images for Urban Land Use Classification (2018)

Urban land use is key to rational urban planning and management. Traditional land use classification methods rely heavily on domain experts, which is both expensive and inefficient. In this paper, deep neural network-based approaches are presented to label urban land use at pixel level using high-resolution aerial images and ground-level street view images. We use a deep neural network to extract semantic features from sparsely distributed street view images and interpolate them in the spatial domain to match the spatial resolution of the aerial images, which are then fused together through a deep neural network for classifying land use categories. Our methods are tested on a large publicly available aerial and street view images dataset of New York City, and the results show that using aerial images alone can achieve relatively high classification accuracy, the ground-level street view images contain useful information for urban land use classification, and fusing street image features with aerial images can improve classification accuracy. Moreover, we present experimental studies to show that street view images add more values when the resolutions of the aerial images are lower, and we also present case studies to illustrate how street view images provide useful auxiliary information to aerial images to boost performances.
Surface Defect Formation in Steel Continuous Casting (2018)

Serious defects in the continuous casting of steel, including surface cracks and depressions, are often related to thermal mechanical behavior during solidification in the mold. A finite-element model has been developed to simulate the temperature, shape, and stress of the steel shell, as it moves down the mold in a state of generalized plane strain at the casting speed. The thermal model simulates transient heat transfer in the solidifying steel and between the shell and mold wall. The thermal model is coupled with a stress model that features temperature-, composition-, and phase dependent elastic-visco-plastic constitutive behavior of the steel, accounting for liquid, δ-ferrite, and γ-austenite behavior. Depressions are predicted to form when the shell is subjected to either excessive compression or tension, but the shapes, severity, and appearance differ with conditions. Cracks appearing without depressions are suggested to form in the lower ductility trough when the shell is colder but more brittle. The local thickness of the shell and austenite layer appears to have major effects as well. The model reveals new insights into the formation mechanisms and behavior of surface depressions and longitudinal cracks in the continuous casting process.
Privatizing Government, in the Interim (2017)

privatization, anarchism, capitalism, utilitarianism, deontology
[Effects of all-trans retinoic acid, arsenic trioxide and daunorubicin on tissue factor expression in NB4 cells]. (1999)

TF expression and PCA of APL cells may be down-regulated by ATRA and As2O3, therefore, As2O3 might also improve DIC-related hemorrhage of APL while inducing APL cells to apoptosis. The distinct regulation of TF and PCA on APL cells by As2O3 and DNR may at least partially contribute to their effects on APL coagulopathy through the influence on coagulant factors activation.
Asymmetric distortion of bis(.mu.-oxo)bis(oxotungstate(V)) complexes. Crystal structure of bis(.mu.-oxo)(.mu.-N,N'-(R)-propylenediaminetetraacetato)bis(oxotungstate(V)) (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric distortion of bis(.mu.-oxo)bis(oxotungstate(V)) complexes. Crystal structure of bis(.mu.-oxo)(.mu.-N,N'-(R)-propylenediaminetetraacetato)bis(oxotungstate(V))Shinji Ikari, Yoichi Sasaki, and Tasuku ItoCite this: Inorg. Chem. 1990, 29, 1, 53–56Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://doi.org/10.1021/ic00326a012RIGHTS & PERMISSIONSArticle Views64Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (464 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Acid ceramidase improves the quality of oocytes and embryos and the outcome of <i>in vitro</i> fertilization (2009)

A major challenge of assisted reproduction technologies (ARTs) is to mimic the natural environment required to sustain oocyte and embryo survival. Herein, we show that the ceramide-metabolizing enzyme, acid ceramidase (AC), is expressed in human cumulus cells and follicular fluid, essential components of this environment, and that the levels of this enzyme are positively correlated with the quality of human embryos formed in vitro. These observations led us to develop a new approach for oocyte and embryo culture that markedly improved the outcome of in vitro fertilization (IVF). The addition of recombinant AC (rAC) to human and mouse oocyte culture medium maintained their healthy morphology in vitro. Following fertilization, the number of mouse embryos formed in the presence of rAC also was improved (from approximately 40 to 88%), leading to approximately 5-fold more healthy births. To confirm these observations, immature bovine oocytes were matured in vitro and subjected to IVF in the presence of rAC. Significantly more high-grade blastocysts were formed, and the number of morphologically intact, hatched embryos was increased from approximately 24 to 70%. Overall, these data identify AC as an important component of the in vivo oocyte and embryo environment, and provide a novel technology for enhancing the outcome of assisted fertilization. Eliyahu, E., Shtraizent, N., Martinuzzi, K., Barritt, J., He, X., Wei, H., Chaubal, S., Copperman, A. B., Schuchman, E. H. Acid ceramidase improves the quality of oocytes and embryos and the outcome of in vitro fertilization.
A Memristor-Based Optimization Framework for Artificial Intelligence Applications (2018)

Memristors have recently received significant attention as device-level components for building a novel generation of computing systems. These devices have many promising features, such as non-volatility, low power consumption, high density, and excellent scalability. The ability to control and modify biasing voltages at memristor terminals make them promising candidates to efficiently perform matrix-vector multiplications and solve systems of linear equations. In this article, we discuss how networks of memristors arranged in crossbar arrays can be used for efficiently solving optimization and machine learning problems. We introduce a new memristor-based optimization framework that combines the computational merits of memristor crossbars with the advantages of an operator splitting method, the alternating direction method of multipliers (ADMM). Here, ADMM helps in splitting a complex optimization problem into subproblems that involve the solution of systems of linear equations. The strength of this framework is shown by applying it to linear programming, quadratic programming, and sparse optimization. In addition to ADMM, implementation of a customized power iteration method for eigenvalue/eigenvector computation using memristor crossbars is discussed. The memristor-based power iteration method can further be applied to principal component analysis. The use of memristor crossbars yields a significant speed-up in computation, and thus, we believe, has the potential to advance optimization and machine learning research in artificial intelligence.
Design of Ligands for the Nicotinic Acetylcholine Receptors:The Quest for Selectivity (2004)

In the last decade, nicotinic acetylcholine receptors (nAChRs) have emerged as important targets for drug discovery. The therapeutic potential of nicotinic agonists depends substantially on the ability to selectively activate certain receptor subtypes that mediate beneficial effects. The design of such compounds has proceeded in spite of a general shortage of data pertaining to subtype selectivity. Medicinal chemistry efforts have been guided principally by binding affinities to the alpha4beta2 and/or alpha7 subtypes, even though these are not predictive of agonist activity at either subtype. Nevertheless, a diverse family of nAChR ligands has been developed, and several analogs with promising therapeutic potential have now advanced to human clinical trials. This paper provides an overview of the structure-affinity relationships that continue to drive development of new nAChR ligands.
A Parallel Framework for Reservoir Simulators on Distributed-memory Supercomputers (2015)

Abstract This paper presents our work on developing a platform for high performance reservoir simulations, which is developed to support the implementation of various reservoir simulators on distributed-memory parallel systems. This platform employs MPI (Message Passing Interface) for communications and OpenMP for shared-memory computation. It provides structured grids due to its simplicity and cell-centered data for each grid cell. The platform has a distributed matrix and vector module and a map module. The map connects the grid and linear system modules. Commonly-used Krylov subspace linear solvers are implemented, including the restarted GMRES method and the BiCGSTAB method. It also has an interface to a parallel algebraic multigrid solver, BoomerAMG from HYPRE. Parallel general-purpose preconditioners and special preconditioners for reservoir simulations are also developed. The numerical experiments show that our platform has excellent scalability and it can simulate giant models with hundreds of millions of grid cells using thousands of CPU cores.
Vaginal estrogen therapy and overactive bladder symptoms in postmenopausal patients after a tension-free vaginal tape procedure: a randomized clinical trial (2005)

The TVT procedure seems to increase the frequency of OAB syndrome in menopause patients. Vaginal estriol therapy significantly reduces symptoms of urinary urgency, has a high rate of patient satisfaction, and can be used to treat postmenopausal women for at least 6 months after a TVT procedure.
High-Speed Pipelined EGG Processor on FPGA (2006)

This paper details the design of a new high-speed pipelined elliptic curve cryptography (ECC) application specific instruction set processor (ASIP) using field programmable gate array (FPGA) technology. A six-stage pipeline has been applied to the design, and pipeline stalls are avoided via instruction reordering and data forwarding. Three complex instructions are introduced to reduce the latency by reducing the overall number of instructions. The new processor shows improvements over previously reported designs in terms of throughput, latency and area. The higher clock frequencies and low latencies lead to the fastest point multiplication time reported in the literature. An FPGA implementation over GF(2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">163</sup> ) is shown, which achieves a point multiplication time of 36.77 microseconds at 77.01 MHz on a Xilinx Virtex-E device-over 50% faster than the best figure previously reported
A Screen for Dominant Negative Mutants of<i>SEC18</i>Reveals a Role for the AAA Protein Consensus Sequence in ATP Hydrolysis (2000)

An evolutionarily ancient mechanism is used for intracellular membrane fusion events ranging from endoplasmic reticulum-Golgi traffic in yeast to synaptic vesicle exocytosis in the human brain. At the heart of this mechanism is the core complex of N-ethylmaleimide-sensitive fusion protein (NSF), soluble NSF attachment proteins (SNAPs), and SNAP receptors (SNAREs). Although these proteins are accepted as key players in vesicular traffic, their molecular mechanisms of action remain unclear. To illuminate important structure-function relationships in NSF, a screen for dominant negative mutants of yeast NSF (Sec18p) was undertaken. This involved random mutagenesis of a GAL1-regulated SEC18 yeast expression plasmid. Several dominant negative alleles were identified on the basis of galactose-inducible growth arrest, of which one, sec18-109, was characterized in detail. The sec18-109 phenotype (abnormal membrane trafficking through the biosynthetic pathway, accumulation of a membranous tubular network, growth suppression, increased cell density) is due to a single A-G substitution in SEC18 resulting in a missense mutation in Sec18p (Thr(394)-->Pro). Thr(394) is conserved in most AAA proteins and indeed forms part of the minimal AAA consensus sequence that serves as a signature of this large protein family. Analysis of recombinant Sec18-109p indicates that the mutation does not prevent hexamerization or interaction with yeast alpha-SNAP (Sec17p), but instead results in undetectable ATPase activity that cannot be stimulated by Sec17p. This suggests a role for the AAA protein consensus sequence in regulating ATP hydrolysis. Furthermore, this approach of screening for dominant negative mutants in yeast can be applied to other conserved proteins so as to highlight important functional domains in their mammalian counterparts.
Stereoselectivity of the folate transporter in rabbit small intestine: Studies with amethopterin enantiomers (2001)

Stereoselectivity of the folate transporter was examined using rabbit intestinal brush border membrane vesicles (BBMV). Methotrexate (MTX) and the antipode (D-amethopterin) were used as model substrates of the transporter. Folic acid (FA) and MTX were actively taken up into BBMV in the presence of an H+ gradient. Initial uptake of FA and MTX was concentration-dependent with Km values of 1.5 and 1.6 microM for FA and MTX, respectively. FA and MTX mutually inhibited uptake in a competitive manner, with Ki values being similar to the corresponding Km values, demonstrating that FA and MTX share the folate transporter. D-Amethopterin also inhibited FA uptake competitively, with a Ki value approximately 60-fold greater than that of MTX, showing that the affinity of the D-isomer (D-amethopterin) to the folate transporter is much less than that of the L-isomer (MTX). The extent of stereoselectivity observed in the present study is consistent with the previously reported differences in plasma concentration between amethopterin enantiomers following oral administration in humans.
Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-xL (2000)

We investigated the in vitro growth inhibitory and apoptotic effects of clinically achievable concentrations of As(2)O(3) (0.5 to 2.0 micromol/L) against human myeloid leukemia cells known to be resistant to a number of apoptotic stimuli. These included chronic myelocytic leukemia (CML) blast crisis K562 and HL-60/Bcr-Abl cells, which contain p210 and p185 Bcr-Abl, respectively, and HL-60 cell types that overexpress Bcl-2 (HL-60/Bcl-2), Bcl-x(L) (HL-60/Bcl-x(L)), MDR (HL-60/VCR), or MRP (HL-60/AR) protein. The growth-inhibitory IC(50) values for As(2)O(3) treatment for 7 days against all these cell types ranged from 0.8 to 1.5 micromol/L. Exposure to 2 micromol/L As(2)O(3) for 7 days induced apoptosis of all cell types, including HL-60/Bcr-Abl and K562 cells. This was associated with the cytosolic accumulation of cyt c and preapoptotic mitochondrial events, such as the loss of inner membrane potential (DeltaPsim) and the increase in reactive oxygen species (ROS). Treatment with As(2)O(3) (2 micromol/L) generated the activities of caspases, which produced the cleavage of the BH3 domain containing proapoptotic Bid protein and poly (ADP-ribose) polymerase. Significantly, As(2)O(3)-induced apoptosis of HL-60/Bcr-Abl and K562 cells was associated with a decline in Bcr-Abl protein levels, without any significant alterations in the levels of Bcl-x(L), Bax, Apaf-1, Fas, and FasL. Although As(2)O(3 )treatment caused a marked increase in the expression of the myeloid differentiation marker CD11b, it did not affect Hb levels in HL-60/Bcr-Abl, K562, or HL-60/neo cells. However, in these cells, As(2)O(3 )potently induced hyper-acetylation of the histones H3 and H4. These findings characterize As(2)O(3) as a growth inhibiting and apoptosis-inducing agent against a variety of myeloid leukemia cells resistant to multiple apoptotic stimuli.
Novel therapies for anti-neutrophil cytoplasmic antibody-associated vasculitis (2001)

High-dose corticosteroids in combination with cytotoxic drugs are universally accepted as the initial approach in vasculitides that are associated with anti-neutrophil cytoplasmic antibodies. Cyclophosphamide is the most effective cytotoxic drug and is used in more severe cases. Because cyclophosphamide has more severe short- and long-term side-effects than methotrexate, methotrexate is used in less severe cases. New prospects for the treatment of vasculitis include novel immunosuppressive agents (e.g. mycophenolate, 15-deoxyspergualin, and leflunomide), sequential chemotherapy (e.g. cyclophosphamide followed by azathioprine or cyclophosphamide followed by methotrexate), intravenous immunoglobulin, tumour necrosis factor-alpha directed therapy, anti-lymphocyte directed therapy (e.g. antithymocyte globulin or anti CD52/anti CD4 antibodies), anti-adhesion molecule directed therapy (e.g. anti-CD18 or intercellular adhesion molecule-1 antisense) or immunoablation using high-dose cytotoxic medication with or without stem cell rescue.
Fluid-Bed Carbonization/Desulfurization of Illinois Coal by the Clean Coke Process: PDU Studies (1977)

The Clean Coke Process combines both fluid-bed carbonization and hydrogenation/liquefaction to convert high-sulfur coal to low-sulfur metallurgical coke, chemical feedstocks, and to a lesser extent, liquid and gaseous fuels. The overall processing scheme, which has previously been described in detail (1), is illustrated by the sketch in Figure 1. Briefly, run-of-mine coal is beneficiated and classified by conventional means and split into two feed portions: a sized fraction suited for fluid-bed processing and a fines fraction suited for high-pressure hydrogenation. The sized feed is dried and subjected to a mild surface oxidation in a nonpressurized bed fluidized with air-enriched flue gas. The dry, preoxidized feed is then carbonized in two stages, at 820°F (440°C) and 1400°F (760°C), in fluid-bed reactors operated at pressures up to 150 psig, to produce low-sulfur char, tar, and gas rich in methane and hydrogen. The fines fraction of the beneficiated coal, combined with run-of-mine coal,