gebhart/patrepeval huggingface dataset:
Graph Convolutional Networks with Motif-based Attention (2019)

The success of deep convolutional neural networks in the domains of computer vision and speech recognition has led researchers to investigate generalizations of the said architecture to graph-structured data. A recently-proposed method called Graph Convolutional Networks has been able to achieve state-of-the-art results in the task of node classification. However, since the proposed method relies on localized first-order approximations of spectral graph convolutions, it is unable to capture higher-order interactions between nodes in the graph. In this work, we propose a motif-based graph attention model, called Motif Convolutional Networks, which generalizes past approaches by using weighted multi-hop motif adjacency matrices to capture higher-order neighborhoods. A novel attention mechanism is used to allow each individual node to select the most relevant neighborhood to apply its filter. We evaluate our approach on graphs from different domains (social networks and bioinformatics) with results showing that it is able to outperform a set of competitive baselines on the semi-supervised node classification task. Additional results demonstrate the usefulness of attention, showing that different higher-order neighborhoods are prioritized by different kinds of nodes.
Hot Electron Plasmon-Resonant Grating Structures for Enhanced Photochemistry: A Theoretical Study (2021)

Metallic grating structures have been shown to provide an effective platform for generating hot electrons and driving electrochemical reactions. Here, we present a systematic theoretical study of the surface plasmon resonance in different corrugated metallic grating structures using computational electromagnetic tools (i.e., the finite difference time domain (FDTD) method). We identify the corrugation parameters that produce maximum resonant field enhancement at commonly used wavelengths for photocatalytic applications (633 nm and 785 nm) in different material systems, including Ag, Au, Cu, Al, and Pt. The absorption spectra of each grating structure have been fitted with the analytical equation obtained from Coupled Mode Theory. We then extracted the absorptive and radiative loss rates. The field enhancement can be maximized by matching the absorption and radiation losses via tuning the geometric parameters. We could improve the average field enhancement of 633 nm and 785 nm modes by a factor of 1.8× and 3.8× for Ag, 1.4× and 3.6× for Au, and 1.2× and 2.6× for Cu. The optimum structures are found to be shallower for Ag, Au, and Cu; deeper for Pt; and to almost remain the same for Al. The gratings become flat for all the metals for increasing the average field enhancement. Overall, Ag and Au were found to be the best in terms of overall field enhancement while Pt had the worst performance.
The healing of tympanic membrane perforations is unaffected by urokinase-type plasminogen activator deficiency (2007)

The healing of tympanic membrane perforations is unaffected by urokinase-type plasminogen activator deficiency
Double-Rotor Flux-Switching Permanent Magnet Machine With Yokeless Stator (2016)

In this paper, novel design of a flux-switching permanent magnet machine (FSPMM) with a yokeless stator and two rotors has been proposed. The proposed machine has been found to perform on par with a 6-slot/13-pole C-core conventional FSPMM in terms of torque output. Additionally, the proposed machine has no significant unbalanced magnetic forces, which is a major challenge in conventional FSPMM with odd number of rotor poles. Step-by-step parametric optimization has been performed using finite-element models of the machine in order to achieve the highest torque with the given magnetic and electrical constraints.
Use of booster inoculations to sustain the clinical effect of an adjuvant breast cancer vaccine (2010)

The HER-2/neu E75 peptide vaccine E75 stimulates specific immunity in disease-free BC patients. However, immunity wanes with time. A vaccine booster is safe and effective in stimulating E75-specific immunity in those patients without ERI. These results suggest that the booster may be most effective at 6 months after completion of the primary vaccination series.
Discovery of a Novel Series of Orally Active Non-Peptide Endothelin-A (ETA) Receptor-Selective Antagonists (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiscovery of a Novel Series of Orally Active Non-Peptide Endothelin-A (ETA) Receptor-Selective AntagonistsAnnette M. Doherty, William C. Patt, Jeremy J. Edmunds, Kent A. Berryman, Billy R. Reisdorph, Mark S. Plummer, Aurash Shahripour, Chet Lee, Xue-Min Cheng, and Cite this: J. Med. Chem. 1995, 38, 8, 1259–1263Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/jm00008a002https://doi.org/10.1021/jm00008a002research-articleACS PublicationsRequest reuse permissionsArticle Views379Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Flight Awareness Collaboration Tool (2018)

FACT is a software program that provides important information about winter weather operations to airline dispatchers and airport personnel. FACT has a "quad" design and shows various maps, text, and tabular information. It also has a team messaging capability. It is meant to be used by airline dispatchers and airport personnel to manage winter storms. This slide set provides a description of FACT that will be released to airline and airport partners who are helping to evaluate FACT. It was most recently presented at a Southwest Airlines meeting at NASA Ames on April 3, 2018.
Homodyne detection applied to bit-oriented holographic memories (2006)

A first experimental demonstration has been realized to inscribe and read by homodyne detection two wavelength multiplexed Bragg gratings in a BaTiO/sub 3/ photorefractive crystal. A red spectrally filtered superluminescent diode was used for both recording and readout. The 50% reflectivity mirror is mounted on a piezo stack. Oscillating this mirror at frequency with an amplitude of about 50 nm allows to detect the homodyne signal with a lock-in amplifier. Experimental data show good agreement with the modeling. In conclusion, homodyne detection seems particularly adapted to increase the data transfer rates of bit-oriented holographic memories.
<title>WCRP: a software development system for efficient wavelet-based image codec design</title> (1998)

A wavelet-based image codec compresses an image with three major steps: discrete wavelet transform, quantization and entropy coding. There are many variants in each step. In this research, we consider a versatile software development system called the wavelet compression research platform (WCRP). WCRP provides a framework to host components of all compression steps. For each compression stage, multiple components are developed and they are contained in WCRP. They include a selection of floating-point and integer filter sets, different transform strategies, a set of quantizers and two different arithmetic coders. A codec can be easily formed by picking up components in different stages. WCRP provides an excellent tool to test the performance of various image codec designs. In addition, WCRP is an extensible system, i.e., new components available in the future can be easily incorporated and quickly tested. It makes the development of new algorithms much easier. WCRP has been used in developing a family of new quantization algorithms that are based on the concept of Binary Description of multi-level wavelet coding objects. These quantization schemes can serve different applications, such as progressive fidelity coding, lossless coding and low complexity coding. Both progressive fidelity coding and lossless coding performance of our codec are among the best in its class. A codec of low implementational complexity is made possible by our memory-scalable quantization scheme.
Ultraclean femtosecond vortices from a tunable high-order transverse-mode femtosecond laser (2017)

Femtosecond optical vortices open a variety of fascinating applications, ranging from femtosecond micro-nano manipulation to vortex strong-field physics. A basic requirement for these applications is that the femtosecond vortex has a clean intensity node for capturing or trapping particles. Thus far, the generation of clean femtosecond vortices remains a challenge. Here, we report on ultraclean femtosecond vortex generation by a femtosecond mode-locked laser operating in a single high-order transverse mode. By controlling the oscillation thresholds of various-order transverse modes in a laser, a pure and mode-order-tunable femtosecond Hermite-Gaussian beam is generated from the mode-locked laser and, subsequently, is converted into the femtosecond vortex by a cylindrical lens mode converter. The obtained femtosecond vortex has an unprecedented ring-to-center intensity contrast of 36 dB measured with a near wavelength-spatial-resolution detecting device, which approaches the theoretical limit of an ideal vortex beam. This Letter may open a wide range of application prospects for femtosecond vortices and motivate novel femtosecond structured beam generation directly from mode-locked lasers.
Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase (2014)

Selective inhibition of neuronal nitric oxide synthase (nNOS) is an important therapeutic approach to target neurodegenerative disorders. However, the majority of the nNOS inhibitors developed are arginine mimetics and, therefore, suffer from poor bioavailability. We designed a novel strategy to combine a more pharmacokinetically favorable 2-imidazolylpyrimidine head with promising structural components from previous inhibitors. In conjunction with extensive structure-activity studies, several highly potent and selective inhibitors of nNOS were discovered. X-ray crystallographic analysis reveals that these type II inhibitors utilize the same hydrophobic pocket to gain strong inhibitory potency (13), as well as high isoform selectivity. Interestingly, select compounds from this series (9) showed good permeability and low efflux in a Caco-2 assay, suggesting potential oral bioavailability, and exhibited minimal off-target binding to 50 central nervous system receptors. Furthermore, even with heme-coordinating groups in the molecule, modifying other pharmacophoric fragments minimized undesirable inhibition of cytochrome P450s from human liver microsomes.
Antialiased parameterized solid texturing simplified for consumer-level hardware implementation (1999)

Article Antialiased parameterized solid texturing simplified for consumer-level hardware implementation Share on Authors: John C. Hart Washington State University, School of EECS, Pullman, WA Washington State University, School of EECS, Pullman, WAView Profile , Nate Carr Washington State University, School of EECS, Pullman, WA Washington State University, School of EECS, Pullman, WAView Profile , Masaki Kameya Washington State University, School of EECS, Pullman, WA Washington State University, School of EECS, Pullman, WAView Profile , Stephen A. Tibbitts Evans and Sutherland Computer Corp (Seattle), 33400 8th Ave. s. #136, Federal Way, WA Evans and Sutherland Computer Corp (Seattle), 33400 8th Ave. s. #136, Federal Way, WAView Profile , Terrance J. Coleman Evans and Sutherland Computer Corp (Seattle), 33400 8th Ave. s. #136, Federal Way, WA Evans and Sutherland Computer Corp (Seattle), 33400 8th Ave. s. #136, Federal Way, WAView Profile Authors Info & Claims HWWS '99: Proceedings of the ACM SIGGRAPH/EUROGRAPHICS workshop on Graphics hardwareJuly 1999 Pages 45–53https://doi.org/10.1145/311534.311575Online:01 July 1999Publication History 19citation391DownloadsMetricsTotal Citations19Total Downloads391Last 12 Months5Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A six-axis micro platform for in situ calibration of MEMS inertial sensors (2016)

This paper reports an advanced multi-axis micro actuation and sensing platform for in situ self-calibration of generic MEMS inertial sensors. Compared to previously reported platforms, the device provides the best performance at smallest footprint, with six-axis actuation at low power consumption, off-axis motion compensation, closed-loop capacitive sensing of applied stimulus, integrated interconnects to an inertial sensor load, and increased shock protection. The entire platform is confined to 9×9 mm2.
High resolution ultrasonic scanning of animal and human tissue in-vivo (1977)

Burns impose one of the most serious injuries to the skin due to the organ's function within the body system and to the body as a whole. In an effort to better deal with the burn wound by the immediate excision and grafting of third degree burns, a high resolution (approximately 0.2 mm) ultrasonic pulse-echo technique was developed for determining burn depth. The experimental subjects were Yorkshire pigs because of the histological similarity between human and porcine skin. Burn depths were readily identifiable immediately postburn with the ultrasonic techniques, as were general trends concerning the burn-viable and viable-fat interfaces. The tissue characteristics, density and acoustic attenuation, effecting the impedance mismatch at the burn-viable tissue interface were investigated. The methods of fluid displacements and specific gravities yielded density values, while spectrum analyses produced attenuation measurements for normal, viable and burned tissue samples.
A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery (2018)

Cell penetrating peptides (CPPs) offer great potential to deliver therapeutic molecules to previously inaccessible intracellular targets. However, many CPPs are inefficient and often leave their attached cargo stranded in the cell's endosome. We report a versatile platform for the isolation of peptides delivering a wide range of cargos into the cytoplasm of cells. We used this screening platform to identify multiple "Phylomer" CPPs, derived from bacterial and viral genomes. These peptides are amenable to conventional sequence optimization and engineering approaches for cell targeting and half-life extension. We demonstrate potent, functional delivery of protein, peptide, and nucleic acid analog cargos into cells using Phylomer CPPs. We validate in vivo activity in the cytoplasm, through successful transport of an oligonucleotide therapeutic fused to a Phylomer CPP in a disease model for Duchenne's muscular dystrophy. This report thus establishes a discovery platform for identifying novel, functional CPPs to expand the delivery landscape of druggable intracellular targets for biological therapeutics.
High-repetition-rate distributed Brillouin sensor based on optical correlation-domain analysis with differential frequency modulation (2011)

A kind of high-repetition-rate distributed Brillouin sensor is proposed and experimentally demonstrated based on optical correlation-domain analysis with differential frequency modulation, where the optical frequencies of the pump and the probe waves are modulated at slightly different RFs so that the temporal position of the measurement is continuously and repeatedly swept along a fiber under test. A distribution map of Brillouin frequency variation along a 100 m optical fiber is acquired at a repetition rate of 20 Hz with an accuracy of ±2.5 MHz and a spatial resolution of about 80 cm.
Joint reconstruction of absorption and refractive properties in propagation-based x-ray phase-contrast tomography via a non-linear image reconstruction algorithm (2016)

Propagation-based X-ray phase-contrast tomography (XPCT) provides the opportunity to image weakly absorbing objects and is being explored actively for a variety of important pre-clinical applications. Quantitative XPCT image reconstruction methods typically involve a phase retrieval step followed by application of an image reconstruction algorithm. Most approaches to phase retrieval require either acquiring multiple images at different object-to-detector distances or introducing simplifying assumptions, such as a single-material assumption, to linearize the imaging model. In order to overcome these limitations, a non-linear image reconstruction method has been proposed previously that jointly estimates the absorption and refractive properties of an object from XPCT projection data acquired at a single propagation distance, without the need to linearize the imaging model. However, the numerical properties of the associated non-convex optimization problem remain largely unexplored. In this study, computer simulations are conducted to investigate the feasibility of the joint reconstruction problem in practice. We demonstrate that the joint reconstruction problem is ill-posed and sensitive to system inconsistencies. Particularly, the method can generate accurate refractive index images only if the object is thin and has no phase-wrapping in the data. However, we also observed that, for weakly absorbing objects, the refractive index images reconstructed by the joint reconstruction method are, in general, more accurate than those reconstructed using methods that simply ignore the object’s absorption.
Synergism between a Novel Chimeric Lysin and Oxacillin Protects against Infection by Methicillin-Resistant <i>Staphylococcus aureus</i> (2010)

Staphylococcus aureus is the causative agent of several serious infectious diseases. The emergence of antibiotic-resistant S. aureus strains has resulted in significant treatment difficulties, intensifying the need for new antimicrobial agents. Toward this end, we have developed a novel chimeric bacteriophage (phage) lysin that is active against staphylococci, including methicillin-resistant S. aureus (MRSA). The chimeric lysin (called ClyS) was obtained by fusing the N-terminal catalytic domain of the S. aureus Twort phage lysin with the C-terminal cell wall-targeting domain from another S. aureus phage lysin (phiNM3), which displayed Staphylococcus-specific binding. ClyS was expressed in Escherichia coli, and the purified protein lysed MRSA, vancomycin-intermediate strains of S. aureus (VISA), and methicillin-sensitive (MSSA) strains of S. aureus in vitro. In a mouse nasal decolonization model, a 2-log reduction in the viability of MRSA cells was seen 1 h following a single treatment with ClyS. One intraperitoneal dose of ClyS also protected against death by MRSA in a mouse septicemia model. ClyS showed a typical pattern of synergistic interactions with both vancomycin and oxacillin in vitro. More importantly, ClyS and oxacillin at doses that were not protective individually protected synergistically against MRSA septic death in a mouse model. These results strongly support the development of ClyS as an attractive addition to the current treatment options of multidrug-resistant S. aureus infections and would allow for the reinstatement of antibiotics shelved because of mounting resistance.
Antimicrobial and Microbicidal Activities of Tea and Catechins against Mycoplasma (1992)

We examined tea extracts, (-) epigallocatechin gallate (EGCg) and theaflavin digallate (TF3) for their antimicrobial and microbicidal activities against Mycoplasma. Green tea and black tea showed antimicrobial activities against M. pneumoniae. At a concentration of 0.2% green tea and black tea showed microbicidal activities against M. pneumoniae and M. orale but not against M. salivarium. Extracts of pu-erh tea showed a slight microbicidal activity against M. pneumoniae and M. orale. EGCg purified from green tea and TF3 from black tea markedly showed microbicidal activities against M. pneumoniae. M. orale and M. salivarium. These results suggest that tea and catechins can be used as prophylactic agents against Mycoplasma pneumoniae infection.
On the conversion of biologically interesting amines to hydroxylamines (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the conversion of biologically interesting amines to hydroxylaminesMark D. Wittman, Randall L. Halcomb, and Samuel J. DanishefskyCite this: J. Org. Chem. 1990, 55, 7, 1981–1983Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/jo00294a005https://doi.org/10.1021/jo00294a005research-articleACS PublicationsRequest reuse permissionsArticle Views1331Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts