gebhart/patrepeval huggingface dataset:
Dynamically reconfigurable systolic array accelerators: a case study with extended Kalman filter and discrete wavelet transform algorithms (2010)

Field programmable gate arrays (FPGAs) are increasingly being adopted as the primary on-board computing system for autonomous deep space vehicles. There is a need to support several complex applications for navigation and image processing in a rapidly responsive on-board FPGA-based computer. Developing such a computer requires the designer to explore and combine several design concepts such as systolic array (SA) design, hardware–software partitioning and partial dynamic reconfiguration (PDR). In this study a microprocessor/co-processor design that can simultaneously accelerate multiple single precision floating-point algorithms is proposed. Two such algorithms are extended Kalman filter (EKF) and discrete wavelet transform (DWT). Key contributions include (i) polymorphic systolic array (PolySA), comprising partial reconfigurable regions that can accelerate algorithms amenable to being mapped onto linear SAs and (ii) performance model to predict the overall execution time of EKF algorithm on the proposed PolySA architecture. When implemented on a low-end Xilinx Virtex4 SX35 FPGA, the design provides a speed-up of at least 4.18x and 6.61x over a state-of-the-art microprocessor used in spacecraft systems for the EKF and DWT algorithms, respectively. The performance of EKF algorithm on the proposed PolySA architecture was compared against the performance on two types of conventional (non-polymorphic) hardware architectures and the results showed that the proposed architecture outperformed the other two architectures in most of the test cases.
Discovery of the Dual Polysaccharide Composition of Emulsan and the Isolation of the Emulsion Stabilizing Component (2008)

Emulsan has been reported as an emulsion stabilizing amphipathic lipoheteropolysaccharide secreted by the oil-degrading bacterium Acinetobacter venetianus RAG-1. Previously, emulsan was regarded as a single polymer. As a result of developing a new purification process, we have discovered that emulsan is a complex of approximately 80% (w/w) lipopolysaccharide (LPS) and 20% (w/w) high molecular weight exopolysaccharide (EPS). The EPS was purified to 98% (w/w) using tangential flow filtration, Triton X-114 phase extraction, ammonium sulfate precipitation, and hydrophobic interaction chromatography. Several previously reported physical properties of emulsan can be attributed to the LPS fraction, such as charge, fatty acid profile, and solution behavior, while the EPS is responsible for the emulsion stabilization activity. The EPS is believed to be cationic in nature, thus providing an electrostatic binding mechanism for the formation of the emulsan complex.
Monoclonal antibody against the common beta subunit (beta c) of the human interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony- stimulating factor receptors shows upregulation of beta c by IL-1 and tumor necrosis factor-alpha (1992)

High-affinity receptors for human granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 are composed of two distinct subunits, alpha and beta. Each receptor has its own ligand-specific alpha subunit, and the three receptors share the common beta subunit, beta c. Using a transfectant of NIH3T3 cells expressing the high-affinity human GM-CSF receptor, monoclonal antibodies (MoAbs) against beta c were generated. These MoAbs specifically bound to cells bearing beta c and immunoprecipitated the beta c protein of 120 Kd. Using these MoAbs, expression of beta c was examined. It is known that IL-1 augments the proliferative response of a human factor-dependent hematopoietic cell line TF-1 to either GM-CSF, IL-3, or IL-5, and that it upregulates the high-affinity receptors for GM-CSF, IL-3, and IL-5. Antibody binding and immunoprecipitation demonstrated that IL-1 increased cell surface expression of beta c. This enhancement by IL-1 was accompanied by an increased level of beta c mRNA. In addition, we found that tumor necrosis factor-alpha (TNF-alpha) also increased the expression of beta c, although it did not augment the proliferative response of TF-1 to GM-CSF, IL-3, and IL-5.
X-14547A, a new ionophorous antibiotic produced by Streptomyces antibioticus NRRL 8167. Discovery, fermentation, biological properties and taxonomy of the producing culture. (1979)

X-14547A is a novel antibiotic produced by a new strain of Streptomyces antibioticus (NRRL 8167). The antibiotic is active in vitro against Gram-positive bacteria and is capable of complexing and transporting divalent as well as monovalent metal cations.
Serogrouping of beta-hemolytic streptococci from throat swabs with nitrous acid extraction and the Phadebact streptococcus test (1982)

A direct extraction of the antigen of group A beta-hemolytic streptococci from 373 throat swabs was done with a microtechnique of the nitrous acid extraction-Phadebact coagglutination method. The technique yielded a 96% agreement with the results obtained by a standard throat culture method in which the Phadebact grouping procedure with overnight broth supernatants was employed.
Contribution of the β‐glucosidase BglC to the onset of the pathogenic lifestyle of <i>Streptomyces scabies</i> (2017)

Common scab disease on root and tuber plants is caused by Streptomyces scabies and related species which use the cellulose synthase inhibitor thaxtomin A as the main phytotoxin. Thaxtomin production is primarily triggered by the import of cello-oligosaccharides. Once inside the cell, the fate of the cello-oligosaccharides is dichotomized: (i) the fuelling of glycolysis with glucose for the saprophytic lifestyle through the action of β-glucosidase(s) (BGs); and (ii) elicitation of the pathogenic lifestyle by the inhibition of CebR-mediated transcriptional repression of thaxtomin biosynthetic genes. Here, we investigated the role of scab57721, encoding a putative BG (BglC), in the onset of the pathogenicity of S. scabies. Enzymatic assays showed that BglC was able to release glucose from cellobiose, cellotriose and all other cello-oligosaccharides tested. Its inactivation resulted in a phenotype opposite to that expected, as reduced production of thaxtomin was monitored when the mutant was cultivated on medium containing cello-oligosaccharides as unique carbon source. This unexpected phenotype could be attributed to the highly increased activity of alternative intracellular BGs, probably as a compensation for bglC inactivation, which then prevented cellobiose and cellotriose accumulation to reduce the activity of CebR. In contrast, when the bglC null mutant was cultivated on medium devoid of cello-oligosaccharides, it instead constitutively produced thaxtomin. This observed hypervirulent phenotype does not fit with the proposed model of the cello-oligosaccharide-mediated induction of thaxtomin production, and suggests that the role of BglC in the route to the pathogenic lifestyle of S. scabies is more complex than currently presented.
Fabrication of solution processed 3D nanostructured CuInGaS<sub>2</sub>thin film solar cells (2014)

In this study we demonstrate the fabrication of CuInGaS₂ (CIGS) thin film solar cells with a three-dimensional (3D) nanostructure based on indium tin oxide (ITO) nanorod films and precursor solutions (Cu, In and Ga nitrates in alcohol). To obtain solution processed 3D nanostructured CIGS thin film solar cells, two different precursor solutions were applied to complete gap filling in ITO nanorods and achieve the desirable absorber film thickness. Specifically, a coating of precursor solution without polymer binder material was first applied to fill the gap between ITO nanorods followed by deposition of the second precursor solution in the presence of a binder to generate an absorber film thickness of ∼1.3 μm. A solar cell device with a (Al, Ni)/AZO/i-ZnO/CdS/CIGS/ITO nanorod/glass structure was constructed using the CIGS film, and the highest power conversion efficiency was measured to be ∼6.3% at standard irradiation conditions, which was 22.5% higher than the planar type of CIGS solar cell on ITO substrate fabricated using the same precursor solutions.
A Novel Hybrid Metal–Organic Framework–Polymeric Monolith for Solid‐Phase Microextraction (2014)

This study describes the fabrication of a novel hybrid metal-organic framework- organic polymer (MOF-polymer) for use as a stationary phase in fritless solid-phase microextraction (SPME) for validating analytical methods. The MOF-polymer was prepared by using ethylene dimethacrylate (EDMA), butyl methacrylate (BMA), and an imidazolium-based ionic liquid as porogenic solvent followed by microwave-assisted polymerization with the addition of 25 % MOF. This novel hybrid MOF-polymer was used to extract penicillin (penicillin G, penicillin V, oxacillin, cloxacillin, nafcillin, dicloxacillin) under different conditions. Quantitative analysis of the extracted penicillin samples using the MOF-organic polymer for SPME was conducted by using capillary electrochromatography (CEC) coupled with UV analysis. The penicillin recovery was 63-96.2 % with high reproducibility, sensitivity, and reusability. The extraction time with the proposed fabricated SPME was only 34 min.
<title>Electrically switchable holograms containing novel PDLC structures</title> (1997)

Switchable holograms offer the possibility of real-time electro-optical control of diffractive optic components. We have recently demonstrated recording of diffractive optic components. We have recently demonstrated recording of transmission holographic Bragg gratings in a material system consisting of a photoinitiator dye, co-initiator, a chain extender, a multifunctional acrylate and a low molecular weight nematic liquid crystal. Low voltage scanning electron microscopy studies have shown that the gratings consist of periodic polymer-dispersed liquid crystal (PDLC) planes. Electrical switching of a first order Bragg diffracted beam into the zero-order with an applied field of 10 V/micrometers was observed. Addition of a surfactant to the pre-polymer syrup reduces the switching field to approximately 5 V/micrometers . Fast response times of the order of microseconds were observed for switching and relaxation. In this paper, we have demonstrated the concept of a switchable guided substrate-mode coupler by writing a slanted transmission grating. The diffracted light form this grating is trapped in a glass slab by total internal reflection. The added electrical switchability of PDLC grating allows for the effective control of the intensity and position for light into or out of the substrate.
High temperature monitoring the height of condensed water in steam pipes (2011)

An in-service health monitoring system is needed for steam pipes to track through their wall the condensation of water. The system is required to measure the height of the condensed water inside the pipe while operating at temperatures that are as high as 250<sup>o</sup>C. The system needs to be able to make real time measurements while accounting for the effects of cavitation and wavy water surface. For this purpose, ultrasonic wave in pulse-echo configuration was used and reflected signals were acquired and auto-correlated to remove noise from the data and determine the water height. Transmitting and receiving the waves is done by piezoelectric transducers having Curie temperature that is significantly higher than 250<sup>o</sup>C. Measurements were made at temperatures as high as 250<sup>o</sup>C and have shown the feasibility of the test method. This manuscript reports the results of this feasibility study.
Polyanhydrides: Stability and novel composition (1988)

Abstract New types of polyanhydrides with advantageous properties with respect to biomedical use were synthesized. The first are aliphatic‐aromatic homopolyanhydrides of the structure: ‐(OOC‐C 6 H 4 ‐O(CH 2 )x‐ CO‐) n (=1−10). These polymers display a zero‐order hydrolytic degradation profile for two to ten weeks, the time period of degradation is a function of the length of the aliphatic chain. Stability studies under anhydrous conditions showed that these polymers underwent reversible self‐depolymerization in chloroform but were stable in solid state for over 6 months at 25°C. The second type of polymer, unsaturated polyanhydride of the structure: [‐(OOC‐CH=CH‐CO) x‐ (OOC‐R‐CO) y‐ ] n , have the advantage of secondary polymerization of double bonds to create a crosslinked matrix. These polymers were prepared from the corresponding diacids polymerized by melt condensation or in solution. Molecular weights of up to 44 000 and 30 000 were achieved for polyanhydrides of p‐carboxyphenoxyalkanoic acid and fumaric acid, respectively.
Rapid Speed Modulation of a Rotary Total Artificial Heart Impeller (2016)

Unlike the earlier reciprocating volume displacement-type pumps, rotary blood pumps (RBPs) typically operate at a constant rotational speed and produce continuous outflow. When RBP technology is used in constructing a total artificial heart (TAH), the pressure waveform that the TAH produces is flat, without the rise and fall associated with a normal arterial pulse. Several studies have suggested that pulseless circulation may impair microcirculatory perfusion and the autoregulatory response and may contribute to adverse events such as gastrointestinal bleeding, arteriovenous malformations, and pump thrombosis. It may therefore be beneficial to attempt to reproduce pulsatile output, similar to that generated by the native heart, by rapidly modulating the speed of an RBP impeller. The choice of an appropriate speed profile and control strategy to generate physiologic waveforms while minimizing power consumption and blood trauma becomes a challenge. In this study, pump operation modes with six different speed profiles using the BiVACOR TAH were evaluated in vitro. These modes were compared with respect to: hemodynamic pulsatility, which was quantified as surplus hemodynamic energy (SHE); maximum rate of change of pressure (dP/dt); pulse power index; and motor power consumption as a function of pulse pressure. The results showed that the evaluated variables underwent different trends in response to changes in the speed profile shape. The findings indicated a possible trade-off between SHE levels and flow rate pulsatility related to the relative systolic duration in the speed profile. Furthermore, none of the evaluated measures was sufficient to fully characterize hemodynamic pulsatility.
Pulse code modulation of CO_2 TEA laser pulse (1980)

The tail of the CO(2) TEA laser pulse has been successfully pulse code modulated with an electrooptic modulator. A CdTe crystal Pockels cell used in a double-pass configuration produced a train of optical pulses 100 nsec wide at a 5-MHz repetition rate. With this multifunctional capability, the CO(2)TEA laser can be utilized for both precision ranging and information transfer. A 92% depth of modulation was observed using this Pockels cell modulator configuration.
Deposition Of Pinhole-Free CoSi2 Film (1989)

New fabrication method produces pinhole-free film of cobalt silicide on silicon substrate. In new method, cobalt and silicon evaporated from electron-beam sources onto substrate of silicon having crystal orientation. Materials deposited in stoichiometric ratio of two silicon atoms to one of cobalt, yielding single-crystal CoSi2 film 5 to 10 nm thick. Layer of amorphous silicon 1 to 2 nm thick deposited on CoSi2. Specimen then annealed at 550 degree C for 10 min. Absence of pinholes critical to operation of multilayer devices employing CoSi2 layers, such as metal base transistor.
Evaluation of the detection and mitigation of time synchronization attacks on the global positioning system (2018)

This paper provides an evaluation of the proposed Time Synchronization Attack Rejection and Mitigation (TSARM) technique. The evaluation platform includes a real GPS spoofing mechanism available in TEXBAT and applied on the raw GNSS measurements obtained from a commercial GPS receiver. The key signatures to observe are the deviations on the clock bias and drift of the receiver under spoofed and normal conditions. The numerical evaluation substantiates the strengths of TSARM and renders great insight to its practicality in mitigating the effects of a real spoofer.
HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib (2016)

Activating mutations in MYD88 are present in ∼95% of patients with Waldenström macroglobulinemia (WM), as well as other B-cell malignancies including activated B-cell (ABC) diffuse large B-cell lymphoma (DLBCL). In WM, mutated MYD88 triggers activation of Bruton tyrosine kinase (BTK). Ibrutinib, a pleiotropic kinase inhibitor that targets BTK, is highly active in patients with mutated MYD88. We observed that mutated MYD88 WM and ABC DLBCL cell lines, as well as primary WM cells show enhanced hematopoietic cell kinase (HCK) transcription and activation, and that HCK is activated by interleukin 6 (IL-6). Over-expression of mutated MYD88 triggers HCK and IL-6 transcription, whereas knockdown of HCK reduced survival and attenuated BTK, phosphoinositide 3-kinase/AKT, and mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in mutated MYD88 WM and/or ABC DLBCL cells. Ibrutinib and the more potent HCK inhibitor A419259, blocked HCK activation and induced apoptosis in mutated MYD88 WM and ABC DLBCL cells. Docking and pull-down studies confirmed that HCK was a target of ibrutinib. Ibrutinib and A419259 also blocked adenosine triphosphate binding to HCK, whereas transduction of mutated MYD88 expressing WM cells with a mutated HCK gatekeeper greatly increased the half maximal effective concentration for ibrutinib and A419259. The findings support that HCK expression and activation is triggered by mutated MYD88, supports the growth and survival of mutated MYD88 WM and ABC DLBCL cells, and is a direct target of ibrutinib. HCK represents a novel target for therapeutic development in MYD88-mutated WM and ABC DLBCL, and possibly other diseases driven by mutated MYD88.
An Extremely Low Methanol Crossover and Highly Durable Aromatic Pore‐Filling Electrolyte Membrane for Direct Methanol Fuel Cells (2007)

A highly durable pore-filling-type electrolyte membrane for direct methanol fuel cells has been developed from a porous polyimide substrate and a wholly aromatic hydrocarbon (see figure). The membrane succeeds in reducing the methanol crossover to several hundred times lower than that of a commercial Nafion membrane. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c1086_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Supplementary Figure 6 from Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma (2023)

<p>Expression of the protein biomarkers in pancreatic cancer tissues. A, Immunohistochemical analysis of REG1A: i) REG1A in poorly differentiated PDAC, ii) luminal REG1A in malignant glands. B, TFF1: i) heterogenous expression in cancer,, ii) luminal TFF1 in malignant gland. C, LYVE1 expression in the scattered lymphatic vessels i) in the muscle layer and ii) in the stroma surrounding malignant gland. D, The biomarker levels during monitoring of pancreatic adenocarcinoma patients: LYVE1, REG1A and TFF1 were measured using ELISA in urine samples collected before surgery and during the patient's follow up. Each point represents log-transformed ELISA values at a particular time point (x-axis).</p>
Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-<i>trans</i>-retinoic acid metabolism (2000)

Retinoids, particularly all-trans-retinoic acid (RA), are potent regulators of cell differentiation, cell proliferation, and apoptosis. The role of all-trans-RA during development and in the maintenance of adult tissues has been well established. The control of all-trans-RA levels in cells and tissues is regulated by the balance between its biosynthesis and its catabolism to inactive metabolites. The cytochrome P450 enzyme P450RAI (herein renamed P450RAI-1) is partially responsible for this inactivation of all-trans-RA. In this report, we describe the identification, molecular cloning, and characterization of a second related enzyme, P450RAI-2, which is also involved in the specific inactivation of all-trans-RA. Transiently transfected P450RAI-2 can convert all-trans-RA to more polar metabolites including 4-oxo-, 4-OH-, and 18-OH-all-trans-RA. Competition experiments with other retinoids suggest that all-trans-RA is the preferred substrate. The high level of expression of P450RAI-2, particularly in the cerebellum and pons of human adult brain, suggests a unique role for this enzyme in the protection of specific tissues from exposure to retinoids.
Two level bulk preload branch prediction (2013)

This paper describes the large capacity hierarchical branch predictor in the 5.5 GHz IBM zEnterprise EC12 microprocessor. Performance analyses in a simulation model and on zEC12 hardware demonstrate the benefit of this hierarchy compared to a smaller one level predictor. Novel structures and algorithms for two level branch prediction are presented. Prediction information about multiple branches is bulk transferred from the second level into the first upon detecting a perceived miss in the first level. The second level does not directly make branch predictions. Access to the second level is limited when it is unlikely to be productive. The second level is systematically searched in an order that is likely to provide hits as early as possible. On the workloads analyzed in the simulation model, measurements show a maximum core performance benefit of 13.8%. On the two workloads analyzed on zEC12 hardware 3.4% and 5.3% system performance improvements are achieved.
Alkanesulfonation of cyclic and high polymeric phosphazenes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkanesulfonation of cyclic and high polymeric phosphazenesHarry R. Allcock, Erick H. Klingenberg, and Mark F. WelkerCite this: Macromolecules 1993, 26, 20, 5512–5519Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ma00072a032https://doi.org/10.1021/ma00072a032research-articleACS PublicationsRequest reuse permissionsArticle Views244Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts