gebhart/patrepeval huggingface dataset:
Structure‐Preserving Reshape for Textured Architectural Scenes (2009)

Abstract Modeling large architectural environments is a difficult task due to the intricate nature of these models and the complex dependencies between the structures represented. Moreover, textures are an essential part of architectural models. While the number of geometric primitives is usually relatively low (i.e., many walls are at surfaces), textures actually contain many detailed architectural elements. We present an approach for modeling architectural scenes by reshaping and combining existing textured models, where the manipulation of the geometry and texture are tightly coupled. For geometry, preserving angles such as oor orientation or vertical walls is of key importance. We thus allow the user to interactively modify lengths of edges, while constraining angles. Our texture reshaping solution introduces a measure of directional autosimilarity to focus stretching in areas of stochastic content and to preserve details in such areas. We show results on several challenging models, and show two applications: Building complex road structures from simple initial pieces and creating complex game‐levels from an existing game based on pre‐existing model pieces.
Standard Reference Materials: SRM 1453, Expanded Polystyrene Board, for Thermal Conductivity from 281 K to 313 K (2012)

This document is based on NISTIR 5838, Room-Temperature Thermal Conductivity of Expanded Polystyrene Board for a Standard Reference Material (May 1996). Most of the content remains the same; the thermal conductivity data and the corresponding uncertainty analysis have been updated to reflect recent modifications in the heat flow determination. The statistical analysis of the data has been updated following an errors-in-variables approach. In addition, the terminology has been updated in conformance with current documentary standards for the guarded-hot-plate test method.
[Preparation of human Fab antibodies against HAb18G by guided selection and chain shuffling technique]. (2004)

By guided-selection and chain shuffling technique, the humanized Fab antibody against HAb18G is obtained, which lays the foundation for further research.
Comparison of antitumor activities of pancreatic ribonuclease and its cross-linked dimer. (1976)

The cross-linked dimer of bovine pancreatic RNase (M.W. 28,000) is significantly more effective than the monomer in inhibiting tumor development in mice when administered i.p. 1 day after inoculation with sarcoma 180J ascites cells. Animals bearing solid tumors were not affected. In AKR/J mice with advanced leukemia, a single i.p. injection of 100 mug of the dimer led to about 50% reduction in the enlarged lymph nodes and the spleen at 24 hr. The half-life of the dimer in the bloodstream has been determined to be 10 min in rats and 6 min in mice, compared to values of 5 and 3.5 min, respectively, for the monomer. Analyses of the tissues of untreated leukemic mice for RNase and RNase inhibitors show that the tumor tissues are not deficient in RNase activity. Considerations of possible mechanisms of action of the dimer indicate that other basic proteins in this size range may merit examination as cytostatic agents toward transformed cells.
Use of Viscosity-Modifying Admixture to Reduce Top- Bar Effect of Anchored Bars Cast with Fluid Concrete (1998)

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Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation (2011)

Recent observations have demonstrated that one of the functions of mesenchymal stem/stromal cells (MSCs) is to serve as guardians against excessive inflammatory responses. One mode of action of the cells is that they are activated to express the interleukin (IL)-1 receptor antagonist. A second mode of action is to create a negative feedback loop in which tumor necrosis factor-α (TNF-α) and other proinflammatory cytokines from resident macrophages activate MSCs to secrete the multifunctional anti-inflammatory protein TNF-α stimulated gene/protein 6 (TSG-6). The TSG-6 then reduces nuclear factor-κB (NF-κB) signaling in the resident macrophages and thereby modulates the cascade of proinflammatory cytokines. A third mode of action is to create a second negative feedback loop whereby lipopolysaccharide, TNF-α, nitric oxide, and perhaps other damage-associated molecular patterns (DAMPs) from injured tissues and macrophages activate MSCs to secrete prostaglandin E(2) (PGE(2)). The PGE(2) converts macrophages to the phenotype that secretes IL-10. There are also suggestions that MSCs may produce anti-inflammatory effects through additional modes of action including activation to express the antireactive oxygen species protein stanniocalcin-1.
Protection of the public and workers in the event of accidental releases of radioactive materials into the environment (1988)

The NRPB has responsibility in the UK for specifying emergency reference levels (intervention levels) of dose to be applied in protecting the public in the event of accidental releases. As a result of the experience gained from the Chernobyl accident, and the evidence about radiation risks provided by the latest Hiroshima and Nagasaki studies, NRPB wishes to review its recommendations on emergency reference levels of dose for the public, and also to provide guidance on the protection of workers in accident situations. The authors give suggestions for the form the new NRPB recommendations might take. The basic principles for planning actions to protect the public are discussed and dose levels for the introduction and withdrawal of countermeasures are proposed. Dose levels are given which it is suggested should not be exceeded by workers involved in dealing with an accident and corresponding dose levels for workers carrying out recovery operations. Any comments received will be taken into account when formal NRPB recommendations are prepared.
Addition of Fluoride to Pit and Fissure Sealants-A Feasibility Study (1976)

The data obtained in this in vitro study indicate that contact with pit and fissure sealants to which NaF has been added in amounts ranging from 2 to 5% substantially increases the fluoride content of the enamel and reduces its solubility in acid. The properties of the materials do not seem to be impaired by the addition of fluoride in these amounts. It thus appears that this approach to providing a backup anticariogenic mechanism may, indeed, be feasible. However, further investigation must be done to confirm the anticariogenic effect and to establish the most efficacious means of fluoride incorporation in the materials.
Genes in the HindIII J fragment of the murine cytomegalovirus genome are dispensable for growth in cultured cells: insertion mutagenesis with a lacZ/gpt cassette (1994)

The organization and function of the genes encoded within the HindIII J region of the murine cytomegalovirus genome were analyzed by transcript mapping and cDNA isolation, nucleotide sequence analysis and identification of open reading frames (ORFs), and construction of recombinant viruses carrying insertions disrupting five of the seven ORFs. This region was found to encode five beta transcripts and one gamma transcript in addition to two beta transcripts previously mapped to the sgg1 locus. Seven open reading frames were identified, and one was recognized as a homolog of a human cytomegalovirus US22 gene family. The five largest ORFs contained within the HindIII J fragment (sgg1, HJ4, HJ5, HJ6, and HJ7) were each disrupted by the insertion of a lacZ/gpt genetic marker cassette. The growth kinetics of all recombinant viruses were investigated and found to be the same as wild-type parental virus, indicating that these five ORFs were dispensable for growth in cell culture.
Technology Over-Consumption: Helping Students Find Balance In A World Of Alluring Distractions (2018)

The last two decades has seen a fundamental shift in society with the growth in technology and the growth of social media. This shift has been embraced in the classroom as a tool to enhance the learning experience of the student. Students have experienced a fundamental shift in interaction with themselves and the world they inhabit with the exponential growth in technology and social media both inside and outside the classroom. The result is the multitasking student, who must constantly switch between growing numbers of interactions. Attention spans have a finite limit, and eventually students experience an over-consumption of technology, characterized by increasing levels of anxiety and stress. To better serve our students, marketing educators must reconsider the technology experience in the classroom. Further, marketing educators should educate students on the detrimental effects of technology over-consumption and solutions to relieve themselves from their over-stressed plugged-in world.
Characterization of Bartonella bacilliformis flagella and effect of antiflagellin antibodies on invasion of human erythrocytes (1993)

Bartonella bacilliformis is the etiologic agent of Oroya fever in humans. Flagellum-mediated motility has been postulated as a major virulence factor for invasion of host cells. To address this hypothesis, we purified and characterized flagella from strain KC584 and then assessed their role in human erythrocyte association and invasion. Electron microscopy of the flagellar preparation showed a high concentration of filaments with a mean wavelength of 800 nm. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis, immunoblot analysis, and KBr density gradient centrifugation indicated that the flagellar filament is composed of a polypeptide of 42 kDa. The flagellin is partially (ca. 50%) resistant to treatment with trypsin. The first 17 amino acid residues of the N terminus of the mature flagellin protein are GAAILTNDNAMDALQDL and show approximately 46% sequence identity to the residues of the N termini of two Caulobacter crescentus flagellin proteins. A monospecific polyclonal antibodies to the flagellin protein was generated, and its specificity was verified by both immunoblot and immunogold analyses. Human erythrocyte invasion assays performed with bartonellae exposed to the antiflagellin antiserum showed a significant decrease in bacterial association with and invasion of human erythrocytes in comparison with that in bartonellae exposed to preimmune rabbit serum or phosphate-buffered saline (PBS) controls. These results suggest that flagella are an important component in the invasiveness of B. bacilliformis.
Investigation of potential RNA bulge stabilizing elements (2005)

As a part of our interest in recognition and cleavage of RNA we carried out thermal melting studies with the aim of screening a number of simple oligonucleotide modifications for their potential as modifying elements for RNA bulge stabilizing oligonucleotides. A specific model system from our studies on oligonucleotide-based artificial nuclease (OBAN) systems was chosen and the bulge size was varied from one to five nucleotides. Introduction of single 2'-modified nucleoside moieties (2'-O-methyl, 2'-deoxy and 2'-deoxy-2'-amino) with different conformational preferences adjacent to the bulge revealed that a higher preference for the north conformers gave more stable bulges across the whole range of bulge sizes. Changing a bulge closing a G-U wobble base pair to a G-C pair resulted in the interesting observation that, although the fully complementary complex and small bulges were highly stabilized, there was little difference in the stability of the larger bulges. The wobble base pair even gave a slight stabilization of the 5 nt bulge system. Introduction of a uridine C-5 linker with a single ammonium group was clearly bulge stabilizing (DeltaT(m) + 4.6 to + 5.4 degrees C for the three most stabilized bulges), although with limited selectivity for different bulge sizes since the fully complementary duplex was also stabilized. Introduction of a naphthoyl group on a 2'-aminolinker mostly gave a destabilizing effect, while introduction of a 5-aminoneocuproine moiety on the same linker resulted in stabilization of all bulges, in particular those with two or four unpaired nucleotides (DeltaT(m) + 3.6 and + 2.9 degrees C respectively). The aromatic groups destabilize the fully complementary duplex, resulting in higher selectivity towards stabilization of bulges. A combination of the studied partial element should be suitable for future designs of modified oligonucleotides that, apart from standard base pairing, can also provide additional non-Watson-Crick recognition of RNA.
The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC (2016)

In the intestinal mucosa, retinoic acid (RA) is a critical signaling molecule. RA is derived from dietary vitamin A (retinol) through conversion by aldehyde dehydrogenases (aldh). Reduced levels of short-chain fatty acids (SCFAs) are associated with pathological microbial dysbiosis, inflammatory disease, and allergy. We hypothesized that SCFAs contribute to mucosal homeostasis by enhancing RA production in intestinal epithelia. With the use of human and mouse epithelial cell lines and primary enteroids, we studied the effect of SCFAs on the production of RA. Functional RA conversion was analyzed by Adlefluor activity assays. Butyrate (0-20 mM), in contrast to other SCFAs, dose dependently induced aldh1a1 or aldh1a3 transcript expression and increased RA conversion in human and mouse epithelial cells. Epithelial cell line data were replicated in intestinal organoids. In these organoids, butyrate (2-5 mM) upregulated aldh1a3 expression (36-fold over control), whereas aldh1a1 was not significantly affected. Butyrate enhanced maturation markers (Mucin-2 and villin) but did not consistently affect stemness markers or other Wnt target genes (lgr5, olfm4, ascl2, cdkn1). In enteroids, the stimulation of RA production by SCFA was mimicked by inhibitors of histone deacetylase 3 (HDAC3) but not by HDAC1/2 inhibitors nor by agonists of butyrate receptors G-protein-coupled receptor (GPR)43 or GPR109A, indicating that butyrate stimulates RA production via HDAC3 inhibition. We conclude that the SCFA butyrate inhibits HDAC3 and thereby supports epithelial RA production.
Intermediates in the epoxidation of alkenes by cytochrome P-450 models. 3. Mechanism of oxygen transfer from substituted oxochromium(V) porphyrins to olefinic substrates (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntermediates in the epoxidation of alkenes by cytochrome P-450 models. 3. Mechanism of oxygen transfer from substituted oxochromium(V) porphyrins to olefinic substratesJ. Mark Garrison and Thomas C. BruiceCite this: J. Am. Chem. Soc. 1989, 111, 1, 191–198Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ja00183a030https://doi.org/10.1021/ja00183a030research-articleACS PublicationsRequest reuse permissionsArticle Views315Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Research on the Empowerment Path of New Infrastructure to Promote the High Quality Development of Public Services for National Fitness (2023)

Using methods such as literature review and logical analysis, this paper systematically sorts out and analyzes the problems of China’s public service system for national fitness in the new development stage. Starting from the empowerment of high-quality economic development by new infrastructure, it explores the current situation and existing problems of public service quality for national fitness,and explores how to improve the quality of public service for national fitness through new infrastructure. Research suggests that although the public service system for national fitness in China has been preliminarily established in the new era, there is still a significant gap with the development of “high-level” and “high-quality”. There are still difficulties in the construction of infrastructure services, smart fitness guidance, sports organization construction, brand event hosting, and other areas. Based on this, from the perspective of new infrastructure, it is proposed to adhere to the concept of “putting the people first”in the supply of public services for national fitness,with the goal of safeguarding the basic sports rights of multi-level citizens and meeting the diversified demand for public services for national fitness.The high-quality development of public services for national fitness is empowered from the production, suppl, and governance levels.
Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate (2000)

Medium-chain triacylglycerols (MCT) are present in milk, coconut oil and other foods, and are used therapeutically in special diets for certain disorders of lipid and glucose utilization. Recently, it has become apparent that MCT are not only oxidized in the liver, but are also present in lymph and fat tissue, particularly after chronic treatment. To evaluate the influence of MCT on metabolism in fat cells, we compared incorporation of octanoate and oleate into cellular triacylglycerols of 3T3-L1 adipocytes as well as their effects on preadipocyte differentiation. We found that less octanoate than oleate was stored and that more octanoate than oleate was oxidized. Octanoate was esterified to a greater extent at the sn-1,3 position of glyceryl carbons than at the sn-2 position, whereas the opposite was true for oleate. Glycerol release from fat cells pre-treated with octanoate was also greater than from cells pre-treated with oleate, presumably related to the preferential release of octanoate from the sn-1,3 position. Octanoate was not incorporated into lipids in undifferentiated cells and did not induce differentiation in these cells, whereas oleate was readily stored and actually induced differentiation. Incorporation of octanoate into lipids increased as cells differentiated, but reached a maximum of about 10% of the total stored fatty acids. If these effects in vitro also occur in vivo, substitution of octanoate for oleate or other long-chain fatty acids could have the beneficial effect of diminishing fat-cell number and lipid content.
Phoneme-level text to audio synchronization on speech signals with background music (2011)

We address the task of synchronizing a given phoneme transcription with the corresponding speech signal, when the latter is linearly mixed with background music. To that end, we propose a new method based on Non-negative Matrix Factorization in the time-frequency domain, which models the speech as a source-filter factorization that includes a synchronization parameter matrix. Phoneme models, which consist of collections of basic spectral envelopes, are learned from a training set of isolated speech. The model is subjected to an iterative Maximum Likelihood optimization that concurrently estimates pitch, synchronization parameters and the contribution of the music part. Results show the feasibility of the system for application in text-informed audio processing and automatic subtitle synchronization.
Transport and magnetic anomalies below<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mn>70</mml:mn><mml:mspace width="0.3em"/><mml:mi mathvariant="normal">K</mml:mi></mml:mrow></mml:math>in a hydrogen-cycled Pd foil with a thermally grown oxide (2005)

Electron transport and magnetic properties have been studied in a deformed $12.5\text{\ensuremath{-}}\ensuremath{\mu}\mathrm{m}$-thick Pd foil with a thermally-grown oxide and a low residual concentration of hydrogen. This foil was deformed by cycling across the Pd hydride miscibility gap and the residual hydrogen was trapped at dislocation cores. Anomalies of both resistance and magnetic susceptibility have been observed below $70\phantom{\rule{0.3em}{0ex}}\mathrm{K}$, indicating the appearance of excess conductivity and a diamagnetic response that we interpret in terms of filamentary superconductivity. These anomalies are attributed to a condensed hydrogen-rich phase at dislocation cores near the $\mathrm{Pd}\text{\ensuremath{-}}\mathrm{Pd}$ oxide interface.
Wearable Reading Assist System: Augmented Reality Document Combining Document Retrieval and Eye Tracking (2013)

We present a new system that assists people's reading activity by combining a wearable eye tracker, a see-through head mounted display, and an image based document retrieval engine. An image based document retrieval engine is used for identification of the reading document, whereas an eye tracker is used to detect which part of the document the reader is currently reading. The reader can refer to the glossary of the latest viewed key word by looking at the see-through head mounted display. This novel document reading assist application, which is the integration of a document retrieval system into an everyday reading scenario for the first time, enriches people's reading life. In this paper, we i) investigate the performance of the state-of-the-art image based document retrieval method using a wearable camera, ii) propose a method for identification of the word the reader is attendant, and iii) conduct pilot studies for evaluation of the system in this reading context. The results show the potential of a document retrieval system in combination with a gaze based user-oriented system.
Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency (2009)

Alpha-1 antitrypsin (A1AT) is a 52 kDa serine protease inhibitor that is synthesized in and secreted from the liver. Although it is present in all tissues in the body the present consensus is that its main role is to inhibit neutrophil elastase in the lung. A1AT deficiency occurs due to mutations of the A1AT gene that reduce serum A1AT levels to <35% of normal. The most clinically significant form of A1AT deficiency is caused by the Z mutation (Glu342Lys). ZA1AT polymerizes in the endoplasmic reticulum of liver cells and the resulting accumulation of the mutant protein can lead to liver disease, while the reduction in circulating A1AT can result in lung disease including early onset emphysema. There is currently no available treatment for the liver disease other than transplantation and therapies for the lung manifestations of the disease remain limited. Gene therapy is an evolving field which may be of use as a treatment for A1AT deficiency. As the liver disease associated with A1AT deficiency may represent a gain of function possible gene therapies for this condition include the use of ribozymes, peptide nucleic acids (PNAs) and RNA interference (RNAi), which by decreasing the amount of aberrant protein in cells may impact on the pathogenesis of the condition.