gebhart/patrepeval huggingface dataset:
Quantitative analysis of fine layering effects: Medium averaging versus synthetic seismograms (1989)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1989Quantitative analysis of fine layering effects: Medium averaging versus synthetic seismogramsAuthors: Cengiz EsmersoyKai HsuMichael SchoenbergCengiz EsmersoySchlumberger‐Doll Research, Kai HsuSchlumberger‐Doll Research, and Michael SchoenbergSchlumberger‐Doll Researchhttps://doi.org/10.1190/1.1889845 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1889845FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1989ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1989 Pages: 1375 publication data© 1989 Copyright © 1989 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Cengiz Esmersoy, Kai Hsu, and Michael Schoenberg, (1989), "Quantitative analysis of fine layering effects: Medium averaging versus synthetic seismograms," SEG Technical Program Expanded Abstracts : 1083-1085. https://doi.org/10.1190/1.1889845 Plain-Language Summary PDF DownloadLoading ...
CAPELANIA E ESPIRITUALIDADE PARA PACIENTES EM HEMODIÁLISE (2021)

A doença renal crônica tem afetado profundamente a vida de milhares de pacientes que estão em tratamento de hemodiálise no Brasil. A possibilidade de cura é muito pequena, e a intervenção se restringe a cuidados paliativos. Este estudo exploratório procurou buscar possíveis respostas para a seguinte questão de pesquisa: O valor do cuidado espiritual tem sido reconhecido como possibilidade de ajuda no enfrentamento da doença renal crônica pelo paciente? O maior volume de pesquisas sobre espiritualidade em pacientes renais crônicos foi encontrado na área da enfermagem apesar de ser um tema interdisciplinar. Religião e espiritualidade foram destacadas como condutoras da capelania. E ela é reconhecida por levar o conforto e propiciar um ambiente de escuta, transcendência e busca do sentido da vida resultando em esperança, tranquilidade, melhor resposta aos tratamentos, potencial de ajuda no enfrentamento da doença, bem-estar espiritual e emocional. É necessário mais pesquisas na área e maior divulgação dessas pesquisas entre o corpo clínico de modo a facilitar a implementação de serviços institucionalizados de capelania nos centros de tratamento. Esses serviços deveriam ser tratados com menos estranhamento por ser parte do cuidado integral do paciente.
Antagonistic binding of substrates to 3-phosphoglycerate kinase monitored by the fluorescent analogue 2′(3′)-<i>O</i>-(2,4,6-trinitrophenyl)adenosine 5′-triphosphate (1994)

The analogue of ATP, 2'(3')-O-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate (TNP-ATP), binds tightly to pig muscle 3-phosphoglycerate kinase. A dissociation constant Kd of 0.0095 +/- 0.0015 mM was determined by fluorimetric titration on the basis of 1:1 stoichiometry. TNP-ATP is a strong competitive inhibitor towards MgATP and MgADP with a Ki of 0.008 +/- 0.001 mM for both substrates. It is also a mixed-type inhibitor towards 3-phosphoglycerate with similar inhibition constants. Binding of TNP-ATP to 3-phosphoglycerate kinase is accompanied by a tenfold intensity increase and a blue shift of about 20 nm in its fluorescence emission spectrum and a shift of the pK of its trinitrophenyl group towards a more acidic pH. These findings suggest that the negatively charged trinitrophenyl group of TNP-ATP significantly contributes to the binding of the analogue. By stepwise replacement of the fluorescent TNP-ATP, the dissociation constants (Kd) for ADP and MgADP binding were determined and found to be 0.78 +/- 0.08 and 0.048 +/- 0.006 mM respectively, which are consistent with the values previously determined by equilibrium dialysis [Molnár and Vas (1993) Biochem J. 293, 595-599]. In similar competitive-titration experiments, ATP and MgATP did not completely substitute for TNP-ATP. For the fraction of the analogue that could be substituted, the dissociation constants for MgATP and ATP were estimated to be 0.27 +/- 0.09 and 0.33 +/- 0.15 mM respectively, close to the values determined by equilibrium dialysis. Using the same method, a significant weakening of binding of both (Mg)ADP and (Mg)ATP could be detected in the presence of 3-phosphoglycerate: their respective Kd values became 0.34 +/- 0.04 and 0.51 +/- 0.22 mM. The reciprocal effect, i.e. weakening of 3-phosphoglycerate binding in the presence of the nucleotide substrates, has been observed previously [Vas and Batke (1984) Eur. J. Biochem. 139, 115-123]. Similarly, a much weaker binding of (Mg)ATP could be observed in the presence of 1,3-bisphosphoglycerate (Kd = 2.30 +/- 0.68 mM). The possible reason for the mutual weakening of substrate binding is discussed in the light of the available structural data.
Glucokinase (<i>GCK</i>) mutations in hyper- and hypoglycemia: Maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy (2003)

Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a crucial role in the regulation of insulin secretion and has been termed the pancreatic beta-cell sensor. Given its central role in the regulation of insulin release, it is understandable that mutations in the gene encoding glucokinase (GCK) can cause both hyperglycemia and hypoglycemia. Heterozygous inactivating mutations in GCK cause maturity-onset diabetes of the young (MODY), characterized by mild hyperglycemia, which is present at birth, but is often only detected later in life during screening for other purposes. Homozygous inactivating GCK mutations result in a more severe phenotype, presenting at birth as permanent neonatal diabetes mellitus (PNDM). Several heterozygous activating GCK mutations that cause hypoglycemia have also been reported. A total of 195 mutations in the GCK gene have been described, in a total of 285 families. There are no common mutations and the mutations are distributed throughout the gene. Mutations that cause hypoglycemia are located in various exons in a discrete region of the protein termed the heterotropic allosteric activator site. The identification of a GCK mutation in hyper- and hypoglycemia has implications for the clinical course and clinical management of the disorder.
Analyzing bilinear neural networks with new curve fitting for application to human motion analysis (2012)

This paper presents a method for the analysis of bilinear neural networks (BNNs) with time delay. A BNN system was proposed to analyze a weak nonlinear model. To analyze this system, we need to solve the equations for the system. In this paper, we propose a method that determines whether it is possible to solve the equations analytically. If this is possible, we propose a concrete method for solving them. This paper also presents new optimum curve fitting for data sampled at discrete times, such as data outputted from a sensor in a mobile phone, and a new BNN system for curve fitting. Moreover, this paper presents one example where the BNN system for curve fitting and other BNN systems are applied to the analysis of human motion.
The 14-3-3 Isoforms Chi and Epsilon Differentially Bind Client Proteins from Developing <i>Arabidopsis</i> Seed (2011)

The 14-3-3-protein family is prominently expressed during seed filling and modulates protein interactions and enzymatic activities, in a phosphorylation-dependent manner. To investigate the role(s) of 14-3-3 proteins in oilseed development, we have begun to characterize the Arabidopsis thaliana 14-3-3 "interactome" for two phylogenetically distinct isoforms. Proteins from developing Arabidopsis seed were incubated with a Sepharose affinity matrix containing covalently bound recombinant Arabidopsis 14-3-3 isoforms chi (χ) or epsilon (ε). Eluted proteins were quantitatively identified using GeLC-MS/MS coupled to spectral counting. Analysis of nine biological replicates revealed a total of 104 putative 14-3-3 binding proteins eluted from this affinity matrix compared to controls. Interestingly, these results imply that χ and ε could have distinct preferences for client proteins. Both isoforms interact with client proteins involved in various metabolic pathways, including glycolysis and de novo fatty acid synthesis. These results suggest 14-3-3 proteins interact with multiple biochemical processes of Arabidopsis seed development. Furthermore, these data suggest isoform specificity of client proteins and possibly even functional specialization between the 14-3-3 isoforms χ and ε in Arabidopsis seed development.
Evaluating negotiation support systems: a conceptualization (1994)

This paper proposes a framework for evaluating negotiation support systems (NSS). In particular, it suggests that researchers should look beyond the usual rational/instrumental perspective, and take into consideration normative/social-emotional factors. Based on a theory of normative reasoning and emotions, we derive a set of NSS functional requirements and five hypotheses to test the effectiveness of NSS.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Deep Video Deblurring (2016)

Motion blur from camera shake is a major problem in videos captured by hand-held devices. Unlike single-image deblurring, video-based approaches can take advantage of the abundant information that exists across neighboring frames. As a result the best performing methods rely on aligning nearby frames. However, aligning images is a computationally expensive and fragile procedure, and methods that aggregate information must therefore be able to identify which regions have been accurately aligned and which have not, a task which requires high level scene understanding. In this work, we introduce a deep learning solution to video deblurring, where a CNN is trained end-to-end to learn how to accumulate information across frames. To train this network, we collected a dataset of real videos recorded with a high framerate camera, which we use to generate synthetic motion blur for supervision. We show that the features learned from this dataset extend to deblurring motion blur that arises due to camera shake in a wide range of videos, and compare the quality of results to a number of other baselines.
Evolutionary Relationships of Microbial Aromatic Prenyltransferases (2011)

The linkage of isoprenoid and aromatic moieties, catalyzed by aromatic prenyltransferases (PTases), leads to an impressive diversity of primary and secondary metabolites, including important pharmaceuticals and toxins. A few years ago, a hydroxynaphthalene PTase, NphB, featuring a novel ten-stranded β-barrel fold was identified in Streptomyces sp. strain CL190. This fold, termed the PT-barrel, is formed of five tandem ααββ structural repeats and remained exclusive to the NphB family until its recent discovery in the DMATS family of indole PTases. Members of these two families exist only in fungi and bacteria, and all of them appear to catalyze the prenylation of aromatic substrates involved in secondary metabolism. Sequence comparisons using PSI-BLAST do not yield matches between these two families, suggesting that they may have converged upon the same fold independently. However, we now provide evidence for a common ancestry for the NphB and DMATS families of PTases. We also identify sequence repeats that coincide with the structural repeats in proteins belonging to these two families. Therefore we propose that the PT-barrel arose by amplification of an ancestral ααββ module. In view of their homology and their similarities in structure and function, we propose to group the NphB and DMATS families together into a single superfamily, the PT-barrel superfamily.
Prevention of Neurocognitive Deficiency in Mucopolysaccharidosis Type II Mice by Central Nervous System–Directed, AAV9-Mediated Iduronate Sulfatase Gene Transfer (2017)

Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is a rare X-linked recessive lysosomal disorder caused by defective iduronate-2-sulfatase (IDS), resulting in accumulation of heparan sulfate and dermatan sulfate glycosaminoglycans (GAGs). Enzyme replacement is the only Food and Drug Administration-approved therapy available for MPS II, but it is expensive and does not improve neurologic outcomes in MPS II patients. This study evaluated the effectiveness of adeno-associated virus (AAV) vector encoding human IDS delivered intracerebroventricularly in a murine model of MPS II. Supraphysiological levels of IDS were observed in the circulation (160-fold higher than wild type) for at least 28 weeks post injection and in most tested peripheral organs (up to 270-fold) at 10 months post injection. In contrast, only low levels of IDS were observed (7-40% of wild type) in all areas of the brain. Sustained IDS expression had a profound effect on normalization of GAG in all tested tissues and on prevention of hepatomegaly. Additionally, sustained IDS expression in the central nervous system (CNS) had a prominent effect in preventing neurocognitive deficit in MPS II mice treated at 2 months of age. This study demonstrates that CNS-directed, AAV9 mediated gene transfer is a potentially effective treatment for Hunter syndrome, as well as other monogenic disorders with neurologic involvement.
Production of 1-Kestose in Transgenic Yeast Expressing a Fructosyltransferase from <i>Aspergillus foetidus</i> (1998)

Sucrose-inducible secretory sucrose:sucrose 1-fructosyltransferase (1-SST) from Aspergillus foetidus has been purified and subjected to N-terminal amino acid sequence determination. The enzyme is extensively glycosylated, and the active form is probably represented by a dimer of identical subunits with an apparent molecular mass of 180 kDa as judged from mobility in seminative acrylamide gels. The enzyme catalyzes fructosyl transfer from sucrose to sucrose producing glucose and 1-kestose. Oligosaccharides with a higher degree of polymerization are not obtained with sucrose as the substrate. The cDNA encoding the A. foetidus 1-SST has been cloned and sequenced. Sequence homology was found to be highest to levanases, but no hydrolytic activity was observed when levan was incubated with the enzyme. Expression of the cloned gene in an invertase-deficient mutant of Saccharomyces cerevisiae resulted in 1-kestose production, with 6-kestose and neokestose being side products of the reaction. Products were well distinguishable from those formed by yeast transformants expressing a cytosolic invertase.
Data market platforms (2020)

Data only generates value for a few organizations with expertise and resources to make data shareable, discoverable, and easy to integrate. Sharing data that is easy to discover and integrate is hard because data owners lack information (who needs what data) and they do not have incentives to prepare the data in a way that is easy to consume by others. In this paper, we propose data market platforms to address the lack of information and incentives and tackle the problems of data sharing, discovery, and integration. In a data market platform, data owners want to share data because they will be rewarded if they do so. Consumers are encouraged to share their data needs because the market will solve the discovery and integration problem for them in exchange for some form of currency. We consider internal markets that operate within organizations to bring down data silos, as well as external markets that operate across organizations to increase the value of data for everybody. We outline a research agenda that revolves around two problems. The problem of market design, or how to design rules that lead to desired outcomes, and the systems problem, how to implement the market and enforce the rules. Treating data as a first-class asset is sorely needed to extend the value of data to more organizations, and we propose data market platforms as one mechanism to achieve this goal.
Biochemical alterations associated with ALS (2011)

Our objective was to identify metabolic pathways affected by ALS using non-targeted metabolomics in plasma, comparing samples from healthy volunteers to those from ALS patients. This discovery could become the basis for the identification of therapeutic targets and diagnostic biomarkers of ALS. Two distinct cross-sectional studies were conducted. Plasma was collected from 62 (Study 1) and 99 (Study 2) participants meeting El Escorial criteria for possible, probable, or definite ALS; 69 (Study 1) and 48 (Study 2) healthy controls samples were collected. Global metabolic profiling was used to detect and evaluate biochemical signatures of ALS. Twenty-three metabolites were significantly altered in plasma from ALS patients in both studies. These metabolites include biochemicals in pathways associated with neuronal change, hypermetabolism, oxidative damage, and mitochondrial dysfunction, all of which are proposed disease mechanisms in ALS. The data also suggest possible hepatic dysfunction associated with ALS. In conclusion, the data presented here provide insight into the pathophysiology of ALS while suggesting promising areas of focus for future studies. The metabolomics approach can generate novel hypotheses regarding ALS disease mechanisms with the potential to identify therapeutic targets and novel diagnostic biomarkers.
Joints in light alloys today: the boundaries of possibility (2008)

(2008). Joints in light alloys today: the boundaries of possibility. Welding International: Vol. 22, No. 9, pp. 597-609.
Liquid crystal microfluidics: surface, elastic and viscous interactions at microscales (2014)

The hydrodynamic properties of nematic liquid crystals are characterized by a complex mutual coupling between flow, viscosity, and nematic order. While the flow behaviour of nematic bulk samples is well known, corresponding studies in microfluidic settings are still at an early stage. The presence of the four confining channel walls – and in particular the nature of the surface anchoring of the nematic order on the walls – adds new phenomena to the already rich and multifaceted flow behaviour. We present an overview of recent studies focusing on the microfluidics of nematic liquid crystals. Particular topics are the functionalization of the channel walls for defined surface anchoring conditions and the resulting structures of the nematic director field, the controlling and tuning of the flow velocity profile and director field configuration and resulting opto-fluidic applications, and the behaviour of topological defects in the flowing nematic and their application for a guided colloidal transport.
Optical switches and logic gates based on self-collimated beams in two-dimensional photonic crystals (2007)

A device for optical switches and logic gates is proposed in two-dimensional photonic crystals based on self-collimated beams. The main structure of the device is a line-defect-induced 3 dB splitter. Investigations show that the phase response of the self-collimated beams in the photonic crystals resembles that of the plane waves propagated in a homogeneous medium. Operating principle, as revealed by both theoretical calculation and finite-difference time-domain simulation, is based on an interference of reflected and transmitted beams of incident self-collimated beams. This device is potentially applicable for photonic integrated circuits.
Reaction Synthesis of (Ti,V)<sub>2</sub>AlC/Al<sub>2</sub>O<sub>3</sub> Composite (2011)

The (Ti,V) 2 AlC/Al 2 O 3 solid solution composite has been synthesized by in situ aluminothermic reduction of the blend powders of Ti, Al, V 2 O 5 and active carbon. The phase evolution during the formation of the composite was examined at the temperature from 500 °C to 1400 °C. Based on the results of X-ray diffractometry (XRD) and differential scanning calorimeter (DSC), a possible reaction mechanism was proposed to explain the formation of (Ti,V) 2 AlC/Al 2 O 3 solid solution composite. Above the melting point of aluminum, liquid Al reacted with titanium to form the intermetallic compound of TiAl. As the temperature increased to 1300 °C, the intermetallic compound of TiAl reacted with TiC to form Ti 2 AlC. The microstructures of the as prepared samples were also analyzed by the scanning electron microscope (SEM) together with the election dispersive spectroscopy (EDS).
Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis (2005)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Safety and Immunogenicity of Six Acellular Pertussis Vaccines and One Whole-Cell Pertussis Vaccine Given as a Fifth Dose in Four- to Six-Year-Old Children (2000)

All the studied DTaP vaccines performed similarly with regard to reactions, whether given as a fifth sequential dose of the same vaccine, a mix of different DTaP vaccines in the 5-dose sequence, or after 3 DTwP and 1 DTaP vaccinations. Large injection site reactions occurred more frequently after the fifth dose of DTaP than after the previous 4 doses. A fifth dose of all DTaP vaccines induced an antibody response to those antigens contained in the vaccine. No DTaP was consistently most or least reactogenic or immunogenic.
Filterfresh: hot replication of java RMI server objects (1998)

This paper presents the design and implementation of a Java package called Filterfresh for building replicated fault-tolerant servers. Maintaining the correctness and integrity of replicated servers is supported by a GroupManager object instantiated with each replica to form a logical group. The Group Managers use a Group Membership algorithm to maintain a consistent group view and a Reliable Multicast mechanism to communicate with other Group Managers. We then demonstrate how Filterfresh can be integrated into the Java RMI facilities. First we use the GroupManager class to construct a fault-tolerant RMI registry called FT Registry-a group of replicated RMI registry servers. Second, we describe our implementation of the FT Unicast-a client-side mechanism that tolerates and masks server failures below the stub layer, transparent to the client. We also present initial performance results, and discuss how general purpose RMI servers can be made highly available using the Filterfresh package.
Intercommunication between mammalian oocytes and companion somatic cells (1991)

Cellular interactions in the mammalian ovarian follicle between its germ-line and somatic cell components are crucial for its development and function. These interactions are mediated by both membrane gap junctions and paracrine factors. Somatic cell-to-oocyte communication is essential for oocyte growth and the regulation of meiotic maturation. In particular, granulosa cells provide nutrients and molecular signals that regulate oocyte development. Oocytes, on the other hand, promote the organization of the follicle, the proliferation of granulosa cells, and the differentiation and function of cumulus cells, a subset of granulosa cells. Determining the nature of the oocyte-to-granulosa cell signals remains a key challenge for future work.