gebhart/patrepeval huggingface dataset:
The derivation of elbow joint forces, and their relation to prosthesis design (1979)

A literature review showed a lack of accurate data for upper limb joint forces. After discussing methods to determine muscle forces, the physiological cross-sections of muscles were used to estimate their strengths. Elbow joint forces were predicted for isometric actions which gave severe loading conditions. The predicted forces were discussed in relation to prosthesis design, and the use of a radial head replacement was recommended.
Cochleate Delivery Vehicles: Applications in Vaccine Delivery (2000)

Cochleates represent a powerful subunit vaccine delivery system, uniquely suited to meeting the challenges of modern vaccine development. The intrinsic properties of cochleates lead to advantages in the important areas of safety, stability, efficacy, immune response targeting, combining vaccines to multiple infectious agents, alternate routes of administration (including oral and intranasal), and the generation of mucosal immunity. Cochleates are alternating layers of cations and negatively charged lipids, in stacked sheets or rolled scrolls, with little or no internal aqueous space. Bacterial membrane proteins or the surface glycoproteins of enveloped viruses can be efficiently integrated into the lipid bilayers of the cochleates. The current study investigated the relative amounts of the different classes and subtypes of antibodies generated in mice in response to the oral administration of influenza glycoprotein cochleates. Analysis of circulating antibody revealed significant levels of flu glycoprotein-specific IgG, IgM, and IgA class, and IgGI and IgG2a subtype, antibodies. Oral administration of influenza glycoprotein cochleates also induced antigen-specific salivary IgA levels. The immune responses induced were protective against infection in the respiratory tract following intranasal challenge with live influenza virus. DNA plasmids and oligonucleotides can also be formulated into cochleates. Cochleates containing a plasmid that expresses the human immunodeficiency virus, (HIV-1), proteins env (gp160), rev, and tat, in mammalian cells, was given to mice orally or by intramuscular injection. Two oral administrations yielded strong splenocyte cytolytic and proliferative responses. These cellular responses were essentially the same as those obtained by analogous intramuscular injection of DNA cochleates. Very small quantities of encochleated DNA were required to induce these responses, whereas a higher dose of naked DNA given orally induced no cytotoxic or proliferative responses. Cochleates containing pathogen proteins or DNA, formulated, adjuvanted, and delivered in a variety of ways, represent powerful tools for dissecting and directing the immune response to complex pathogens. The ability of cochleates to induce antibody and cell mediated responses, systemically and on mucosal surfaces, makes them desirable candidates for development of preventive and therapeutic vaccines.
Fabrication and characterization of high aspect ratio perpendicular patterned information storage media in an Al2O3/GaAs substrate (1999)

In a new approach, we have fabricated 6:1 aspect ratio magnetic nanocolumns, 60–250 nm in diameter, embedded in a hard aluminum-oxide/gallium-arsenide (Al2O3/GaAs) substrate. The fabrication technique uses the highly selective etching properties of GaAs and AlAs, and highly efficient masking properties of Al2O3 to create small diameter, high aspect ratio holes. Nickel (Ni) is subsequently electroplated into the holes, followed by polishing, which creates a smooth and hard surface appropriate for future reading and writing of the columns as individual bits for high density information storage. We have used magnetic force microscopy and scanning magneto-resistance microscopy to characterize the resulting magnets. We find the columns more magnetically stable than previously achieved with magnets embedded in a SiO2 substrate. Such stability is necessary before further writing of perpendicular patterned media can be demonstrated.
Quantization Noise Mitigation via Parallel ADCs (2014)

In systems with parallel analogue-to-digital converters (ADC), diversity combining can improve the signal to noise ratio (SNR) of the digitised signal. We consider a novel architecture, where the parallel ADCs operate on differently attenuated signals, in conjunction with maximal ratio combining and gain weighted combining. Both schemes reduce the effective quantization noise and provide significant SNR improvements over a single ADC and signal averaging, which takes the unweighted average of the ADC output signals. The key to achieving these SNR gains is to carefully select branch attenuations that lead to negative correlation of the quantization noise across branches.
Effect of filament temperature on the chemical vapor deposition of fluorocarbon–organosilicon copolymers (2003)

Abstract The effect of filament temperature on the hot‐filament chemical vapor deposition (HFCVD) of fluorocarbon–organosilicon copolymer thin films from 1,3,5‐trivinyl‐1,3,5‐trimethylcyclotrisiloxane (V 3 D 3 ) and perfluorooctane sulfonyl fluoride (PFOSF) was examined. Significant changes in chemical structure occur as the filament temperature is varied, and these changes give rise to differences in thermal and mechanical properties. When the filament temperature is low, the films consist primarily of carbon‐backbone polymer chains with siloxane ring pendant groups. When higher filament temperatures are used, the film structure consists of siloxane‐backbone chains with some degree of crosslinking. Films produced with low filament temperatures have a greater degree of thermal stability and flexibility than those produced with high filament temperatures. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 2176–2185, 2004
On the Cost of Introducing Speech-Like Properties to a Stimulus for Auditory Steady-State Response Measurements (2018)

Validating hearing-aid fittings in prelingual infants is challenging because typical measures (aided audiometry, etc.) are impossible with infants. One objective alternative uses an aided auditory steady-state response (ASSR) measurement. To make an appropriate measurement, the hearing aid's signal-processing features must be activated (or deactivated) as if the ASSR stimulus was real speech. Rather than manipulating the hearing-aid settings to achieve this, an ASSR stimulus with speech-like properties was developed. This promotes clinical simplicity and face validity of the validation. The stimulus consists of narrow-band CE-Chirps®, modified to mimic the International Speech Test Signal (ISTS). This study examines the cost of introducing the speech-like features into the ASSR stimulus. Thus, 90 to 100 Hz ASSRs were recorded to the ISTS-modified stimulus as well as an equivalent stimulus without the ISTS modification, presented through insert phones to 10 young normal-hearing subjects. Noise-corrected ASSR magnitudes and clinically relevant detection times were estimated and analyzed with mixed-model analyses of variance. As a supplement, the observed changes to the ASSR magnitudes were compared with an objective characterization of the stimuli based on modulation power. The main findings were a reduction in ASSR magnitude of 4 dB and an increase in detection time by a factor of 1.5 for the ISTS-modified stimulus compared with the standard. Detection rates were unaffected given sufficient recording time. For clinical use of the hearing-aid validation procedure, the key metric is the detection time. While this varied considerably across subjects, the observed 50% mean increase corresponds to less than 1 min of additional recording time.
3D nanomanipulation using atomic force microscopy (2004)

The use of atomic force microscope (AFM) as a nanomanipulator has been evolving for various kinds of nanomanipulation tasks. Due to the bow effect of the piezo scanner of the AFM, the AFM space is different from the Cartesian space. In this paper, different 3-D nanomanipulation tasks using AFM such as nanolithography, pushing and cutting are discussed. 3-D path planning are performed directly in the AFM space and the 3-D paths are generated based on the 3-D topography information of the surface represented in the AFM space. This approach can avoid the mappings between the AFM space and Cartesian space in planning. By following the generated motion paths, the tip can either follow the topography of the surface or move across the surface by avoiding collision with bumps. Nanomanipulation using this method can be considered as the "true" 3-D operations since the cantilever tip can be controlled to follow any desired 3-D trajectory within the range of AFM space. The experimental study shows the effectiveness of the planning and control scheme.
An Improved Scheme for Initial Ranging in OFDMA-Based Networks (2008)

An efficient scheme for initial ranging has recently been proposed by X. Fu et al. in the context of orthogonal frequency-division multiple-access (OFDMA) networks based on the IEEE 802.16e-2005 standard. The proposed solution aims at estimating the power levels and timing offsets of the ranging subscriber stations (RSSs) without taking into account the effect of possible carrier frequency offsets (CFOs) between the received signals and the base station local reference. Motivated by the above problem, in the present work we design a novel ranging scheme for OFDMA in which the ranging signals are assumed to be misaligned both in time and frequency. Our goal is to estimate the timing errors and CFOs of each active RSS. Specifically, CFO estimation is accomplished by resorting to subspace-based methods while a least-squares approach is employed for timing recovery. Computer simulations are used to assess the effectiveness of the proposed solution and to make comparisons with existing alternatives.
Possibilities for projection x-ray lithography using holographic optical elements (1991)

Projection x-ray lithography has received considerable attention recently as a way of pushing circuit feature size below the level at which proximity printing schemes become problematic. However, the optical figure tolerances for the projection systems usually discussed are well beyond the current state of the art. We consider the use of computer-generated holograms for printing circuit features. One scheme involves the use of an off-axis phase hologram written as surface height variations on a grazing incidence optical flat. Another scheme we have studied extensively through computer simulations involves the use of a transmission mask with material thickness variations designed in such a way that the magnitude and phase of the transmitted wavefield is controlled to produce the desired pattern with low noise and high contrast. Both schemes involve only modest extensions of existing technologies, and offer a route to x-ray projection lithography of sub-0.1-µm circuit features.
Algorithmically Specialized Parallel Architecture For Robotics (1991)

Computing system called Robot Mathematics Processor (RMP) contains large number of processor elements (PE's) connected in various parallel and serial combinations reconfigurable via software. Special-purpose architecture designed for solving diverse computational problems in robot control, simulation, trajectory generation, workspace analysis, and like. System an MIMD-SIMD parallel architecture capable of exploiting parallelism in different forms and at several computational levels. Major advantage lies in design of cells, which provides flexibility and reconfigurability superior to previous SIMD processors.
Generation of redundant frame structure for interactive multiview streaming (2009)

While multiview video coding focuses on the rate-distortion performance of compressing all frames of all views, we address the problem of designing a frame structure to enable interactive multiview streaming, where clients can interactively switch views during video playback. Thus, as a client is playing back successive frames (in time) for a given view, it can send a request to the server to switch to a different view while continuing uninterrupted temporal playback. Noting that standard tools for random access (i.e., I-frame insertion) can be inefficient for this application, we propose a technique where redundant representations of some frames can be stored to facilitate view switching. We first present an optimal algorithm with exponential running time that generates such a frame structure so that the expected transmission rate is optimally traded off with total storage. We then present methods to reduce the algorithm complexity for practical use. We show in our experiments that we can generate redundant frame structures offering a range of tradeoff points with transmission and storage, including ones that outperform simple I-frame insertion structures by up to 48% in terms of bandwidth efficiency for similar storage costs.
Progress in rolling bearing technology for refrigerant compressors (2017)

The paper describes the latest technological solutions in rolling bearings (ball and roller) used in refrigerant compressors. First, the numerous tribological challenges faced by rolling contacts in a lubricant environment made of oil and refrigerant mixture are discussed. It is followed by a description of the even tougher conditions derived by the replacement of the more chemically stable pre-Montreal and pre-Kyoto Protocol refrigerants by the new generation of more environmental friendly refrigerants. In these conditions, rolling bearings are expected to suffer from surface distress and sometimes corrosion fatigue. Thus, attempts to model these conditions by using advanced tribological models are described. Finally, descriptions of different solutions in rolling bearings in refrigerant compressors facing challenges in lubrication and bearing life are described, all the way from traditional oil–refrigerant mixture lubrication up to the latest innovation related to oil-free lubrication, namely the pure refrigerant lubrication.
A novel human leucocyte surface membrane antigen defined by murine monoclonal antibody (1990)

A murine monoclonal antibody has been produced which identifies a novel human leucocyte differentiation antigen. The antibody, designated WM-66, of IgM subclass, was cytolytic with human complement. WM-66 was shown to react with virtually all normal T and B lymphocytes from peripheral blood and lymphoid tissues, as well as blood monocytes and approximately 40% of bone marrow mononuclear cells. The antibody also bound to the majority of cases of chronic B-cell malignancies, including chronic lymphatic leukaemia and non-Hodgkin's lymphoma, but not to cases of acute leukaemia or to the majority of leukaemic and lymphoblastoid cell lines. WM-66 also reacted with epithelium of bronchus and salivary gland ducts. A single band of relative molecular mass 65,000 Daltons was immunoprecipitated from membrane extracts of normal lymphocytes and the B-cell line Daudi. Treatment of a number of WM-66-negative B-cell lines with neuraminidase resulted in WM-66 binding, indicating that the antigen exists in a covert form masked by sialic acid residues on a wider spectrum of cell types than was initially apparent. The reactivity pattern of WM-66 indicates that it recognises a previously undescribed surface membrane molecule with broad non-lineage-specific distribution on leucocytes. This has recently been confirmed at the Fourth International Workshop on Human Leucocyte Differentiation Antigens. Although the biological function of the molecule recognised by WM-66 is unknown, the lytic properties of the antibody suggest a possible in vivo therapeutic role as an immunosuppressant or for treatment of lymphoid malignancy.
Abstract B013: A soluble form of CD80 enhances anti-tumor immunity by inhibiting PDL1 immune suppression and does not suppress via CTLA-4 (2016)

Abstract Tumor cells employ various methods of immune suppression to overcome anti-tumor immunity. One such method is that of the integral membrane protein programmed death ligand-1 (PDL1), which triggers apoptotic death or anergy upon binding programmed death-1 (PD1) on T cells. Treatment of PDL1+ tumor cells with a soluble form of the costimulatory molecule CD80 (CD80-Fc) prevented PDL1-mediated immune suppression by binding PDL1 and blocking interaction with PD1, thus restoring T cell activation. Additionally, CD80-Fc maintained activation of T cells in vitro more effectively than either PD1 or PDL1 antagonist monoclonal antibodies. Because CTLA-4 is also a receptor for CD80 and CD80-Fc has the potential to bind and deliver inhibitory signals into T cells via CTLA-4, it is important to assess CD80-Fc and CTLA-4 interactions. Healthy donor human PBMC stimulated with PHA for three days express CD28, PDL1, and CTLA-4 at the cell surface. To determine which of these receptors CD80-Fc binds to, we have blocked subsets of the receptors using very high concentrations of specific antibodies, and monitored CD80-Fc binding by flow cytometry. CD80-Fc binds to activated T cells blocked for CD28 and PDL1, PDL1 and CTLA-4, or CTLA-4 and CD28, and did not bind when all three receptors were blocked. These findings indicate that CD80-Fc binds to CTLA-4. However, inclusion of CTLA-4 antagonist antibodies L3D10 or Ipilimumab in co-cultures of human PBMC and PDL1+ C8161 human melanoma cells did not increase T cell production of IFNγ, suggesting that CD80-Fc is not suppressing through CTLA-4. Historically, CTLA-4 has been considered as a negative regulator of T cell function through its ability to deliver suppressive signals to T cells. Recent re-evaluations of CD80-CTLA-4 interactions suggest that CTLA-4 inhibits T cell function not by delivering intracellular signals, but by serving as a decoy receptor for CD80. Our results support this alternative functional mechanism and are consistent with the concept that CD80-Fc maintains T cell activation by saturating CTLA-4 receptors while simultaneously blocking PDL1 suppression and providing CD28 costimulation. Citation Format: Lucas Horn, Virginia Clements, Suzanne Ostrand-Rosenberg. A soluble form of CD80 enhances anti-tumor immunity by inhibiting PDL1 immune suppression and does not suppress via CTLA-4. [abstract]. In: Proceedings of the CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(1 Suppl):Abstract nr B013.
Enhanced performance of an electric oxygen-iodine laser (2010)

Experiments and modeling have led to continued enhancements in the Electric Oxygen-Iodine Laser (ElectricOIL) system. This continuous wave (cw) laser operating on the 1315 nm transition of atomic iodine is pumped by the production of O<sub>2</sub>(a) in a radio-frequency (RF) discharge in an O<sub>2</sub>/He/NO gas mixture. New discharge geometries have led to improvements in O<sub>2</sub>(a) production and efficiency. A 95% enhancement in cw laser power was achieved via a 50% increase in gain length, flow rates, and discharge power. A further 87% increase in extracted laser power was obtained using a larger mode volume resonator. The gain has improved by more than 100-fold from the initial demonstration of 0.002% cm<sup>-1</sup> to 0.26% cm<sup>-1</sup>, and similarly the outcoupled laser power has improved more than 500-fold from 0.16 W to 102 W.
Acoustic characterization of microbubble dynamics in laser-induced optical breakdown (2003)

A real-time acoustic technique to characterize microbubbles produced by laser-induced optical breakdown (LIOB) in water was developed. Femtosecond laser pulses are focused just inside the surface of a small liquid tank. A tightly focused, high frequency, single-element ultrasonic transducer is positioned so its focus coincides axially and laterally with this laser focus. When optical breakdown occurs, a bubble forms and a pressure wave is emitted (i.e., acoustic emission). In addition to this acoustic signal, the microbubble is actively probed with pulse-echo measurements from the same transducer. After the bubble forms, received pulse-echo signals have an extra pulse, describing the bubble location and providing a measure of axial bubble size. Wavefield plots of successive recordings illustrate the generation, growth, and collapse of cavitation bubbles due to optical breakdown. These same plots also can be used to quantify LIOB thresholds.
Pupil-fill imperfections and their effect on lithography (2003)

As lens aberrations are continuously reduced, the effects of imperfections in the pupil fill, or the partial-coherence pattern produced by the illuminator of a lithographic tool, are rising up out of the noise level and becoming important. Imperfections in the pupil fill of Nikon S204-generation scanners were previously measured and found to have minimal lithographic effect. Now, pupil-fill effects in new-generation high-NA scanners have been measured and characterized. We present a systematic study of pupilgrams, measured with a pinhole reticle while exercising illuminator adjustments, and correlate them with simultaneous measurements of CD uniformity and V-H bias to evaluate the importance of the illuminator in overall CD performance. We also present two novel analysis schemes that are used to assess the pupilgrams and are shown to be reasonable predictors of CD performance.
Scalable context-sensitive flow analysis using instantiation constraints (2000)

This paper shows that a type graph (obtained via polymorphic type inference) harbors explicit directional flow paths between functions. These flow paths arise from the instantiations of polymorphic types and correspond to call-return sequences in first-order programs. We show that flow information can be computed efficiently while considering only paths with well matched call-return sequences, even in the higher-order case. Furthermore, we present a practical algorithm for inferring type instantiation graphs and provide empirical evidence to the scalability of the presented techniques by applying them in the context of points-to analysis for C programs.
Use of NS-4 peptides to identify type-specific antibody to hepatitis C virus genotypes 1, 2, 3, 4, 5 and 6 (1995)

The 5' end of the NS-4 protein of different genotypes of hepatitis C virus (HCV) is highly variable in nucleotide and inferred amino acid sequence, with frequent predicted amino acid substitutions between all six of the major HCV genotypes described to date. This region has been shown to be antigenic by epitope mapping, and elicits antibody in HCV-infected individuals with a detectable type-specific component. We have used this sequence data to specify branched peptides for an indirect binding/competition assay to detect type-specific antibody to each major genotype. A total of 183 out of 210 samples (87%) from blood donors and patients with chronic hepatitis C infected with genotypes 1 to 6 showed detectable type-specific antibody to NS-4 peptides that in almost all cases (> 97 %) corresponded to the genotype detected by a PCR typing method. These findings demonstrate the existence of major antigenic differences between genotypes of HCV, and indicate how infection with different variants of HCV may be detected by a serological test.