gebhart/patrepeval huggingface dataset:
Optical Spectroscopy of Conductive Junctions in Plasmonic Cavities (2010)

The optical properties of a nanoparticle dimer bridged by a conductive junction depend strongly on the junction conductivity. As the conductivity increases, the bonding dimer plasmon blueshifts and broadens. For large conductance, a low energy charge transfer plasmon also appears in the spectra with a line width that decreases with increasing conductance. A simple physical model for the understanding of the spectral feature is presented. Our finding of a strong influence of junction conductivity on the optical spectrum suggests that plasmonic cavities might serve as probes of molecular conductance at elevated frequencies not accessible through electrical measurements.
AUD4, a new amplifiable element from Streptomyces lividans The GenBank accession number for the sequence reported in this paper is AF072709. (1999)

After transformation of the Streptomyces lividans chloramphenicol-sensitive, arginine-auxotrophic mutant strain AJ100 with a derivative of plasmid SCP2, some of the regenerated protoplasts contained an 8.2 kb DNA sequence amplified to several hundred copies per chromosome. The corresponding non-amplified sequence, called AUD4, was isolated from a lambda phage genomic library of S. lividans 1326. Two cytosine residues were the only directly repeated nucleotides at the ends of the element, indicating that AUD4 is a class I amplifiable sequence. The element mapped in the AseI-D fragment of the S. lividans chromosome, where other class I amplifications have been described. The complete element was sequenced and 10 ORFs were identified. Some of the deduced proteins are highly conserved in other organisms but a putative function could be attributed to only a few of them. Duplication of AUD4 by integration of an Escherichia coli plasmid carrying various parts of AUD4 and a thiostrepton-resistance gene in S. lividans AJ100, ZX7 or TK64 induced amplification of the integrated plasmid, AUD4 or both at high frequency.
Activation of Bak, Bax, and BH3-only Proteins in the Apoptotic Response to Doxorubicin (2002)

The anthracyclin doxorubicin (DXR) is a major antitumor agent known to cause cellular damage via a number of mechanisms including free radical formation and inhibition of topoisomerase II. It is not clear, however, how the subsequent lesions may lead to the apoptotic death of the cell. We have here examined the effects of DXR on activation of pro-apoptotic members of the Bcl-2 family, all of which are connected to the mitochondrial events of apoptosis. In two human cell lines (lymphoma and myeloma), clinically relevant concentrations of DXR were found to induce apoptosis, first observed after 24 h of treatment. Apoptosis correlated with modulation of Bak and Bax to their active conformations. bax- as well as bak-deficient mouse embryo fibroblasts were resistant to DXR compared with wild-type mouse embryo fibroblasts further supporting a role for these proteins as main DXR-induced apoptosis regulators. Furthermore, using immunocytochemistry as well as chemical blocking of putative apical pathways we could demonstrate that Bak is activated prior to Bax. In the human cell lines, DXR was furthermore found to induce high protein levels of Bik, another BH3-only protein. DXR-induced apoptosis was completely blocked in Bcl-2-overexpressing U266 cells. Interestingly, in Bcl-2-transfected cells Bak activation was also blocked, while Bax was still partially active in agreement with differential regulation of these two proteins. Furthermore, co-incubation of the phosphatidylinositol 3-kinase (PI3K)-inhibitor LY294002 potentiated the apoptotic response to DXR. This enhanced apoptosis was preceded by enhanced Bak and Bax activation, and both responses as well as apoptosis were blocked in transfectants overexpressing Bcl-2. In summary, several pieces of evidence suggest that DXR induces apoptosis through a sequential and differential activation of Bak and Bax.
Implicit 3D Orientation Learning for 6D Object Detection from RGB Images (2019)

We propose a real-time RGB-based pipeline for object detection and 6D pose estimation. Our novel 3D orientation estimation is based on a variant of the Denoising Autoencoder that is trained on simulated views of a 3D model using Domain Randomization. This so-called Augmented Autoencoder has several advantages over existing methods: It does not require real, pose-annotated training data, generalizes to various test sensors and inherently handles object and view symmetries. Instead of learning an explicit mapping from input images to object poses, it provides an implicit representation of object orientations defined by samples in a latent space. Our pipeline achieves state-of-the-art performance on the T-LESS dataset both in the RGB and RGB-D domain. We also evaluate on the LineMOD dataset where we can compete with other synthetically trained approaches. We further increase performance by correcting 3D orientation estimates to account for perspective errors when the object deviates from the image center and show extended results.
Recent advances in radial basis function networks (1999)

In 1996 an Introduction to Radial Basis Function Networks was published on the web 2 along with a package of Matlab functions 3 . The emphasis was on the linear character of RBF networks and two techniques borrowed from statistics: forward selection and ridge regression. This document 4 is an update on developments between 1996 and 1999 and is associated with a second version of the Matlab package 5 . Improvements have been made to the forward selection and ridge regression methods and a new method, which is a cross between regression trees and RBF networks, has been developed. 1 mjo@anc.ed.ac.uk 2 www.anc.ed.ac.uk/mjo/papers/intro.ps 3 www.anc.ed.ac.uk/mjo/software/rbf.zip 4 www.anc.ed.ac.uk/mjo/papers/recad.ps 5 www.anc.ed.ac.uk/mjo/software/rbf2.zip 2 CONTENTS Contents 1 Introduction 3 1.1 MacKay&apos;s Hermite Polynomial . . . . . . . . . . . . . . . . . . . . . 3 1.2 Friedman&apos;s Simulated Circuit . . . . . . . . . . . . . . . . . . . . . . 4 2 Maximum Margina...
Direct Effects of Halothane on Coronary Blood Flow, Myocardial Oxygen Consumption, and Myocardial Segmental Shortening in In Situ Canine Hearts (1995)

Previous in vivo studies of the coronary vascular effects of halothane (HAL) were complicated by varying hemodynamic conditions and global cardiac work demands. Accordingly, the current study evaluated changes in coronary blood flow (CBF) and associated variables during selective intracoronary administrations of HAL in in situ canine hearts using an extracorporeal-controlled pressure perfusion system. Findings during HAL were compared to those during isoflurane (ISO). The left anterior descending coronary artery (LAD) of 8 open-chest dogs anesthetized with fentanyl and midazolam was perfused at constant pressure (109 +/- 2 mm Hg) with HAL-free arterial blood or with blood equilibrated in an extracorporeal oxygenator with HAL (0.5%, 1.0%, 2.0% in 95% O2-5.0% CO2). In the LAD bed, measurements of CBF were obtained with an electromagnetic flowmeter and used to calculate myocardial oxygen consumption (MVO2). Percent segmental shortening (%SS) was measured with ultrasonic crystals. Changes in CBF by HAL were compared to those during maximal vasodilation with adenosine. Separate studies (n = 5) were performed using 1.4% [1 minimum alveolar anesthetic concentration (MAC)] ISO and the findings compared to those during an equianesthetic (1.0%) concentration of HAL. HAL caused concentration-dependent increases in CBF, and decreases in MVO2 and %SS. With 2.0% HAL, the level of CBF was 50% of the maximal adenosine-induced response. At equianesthetic concentrations, HAL caused increases in CBF that were one-third of those caused by ISO, while the decreases in MVO2 and %SS caused by the drugs were not significantly different.(ABSTRACT TRUNCATED AT 250 WORDS)
Abstract 572: Role Of Human Cardiac RLC In Modulating The Super-relaxed State Of Myosin: A Cardiomyopathy Perspective (2018)

Myosin regulatory light chain (RLC) is a major regulatory subunit of the myosin molecule, the role of which has been well-characterized in non-striated muscle. However, in striated muscle, its purpose is less well defined, and it is only in the past decade that researchers have started unraveling the function of RLC and its phosphorylation in muscle contraction. Mutations in this protein result in ~ 2% of total familial cardiomyopathy, an autosomal dominant disorder, manifested by ventricular and septal hypertrophy and myofibrillar disarray that can lead to sudden cardiac death. In this study, we report the role of human cardiac RLC in forming the super-relaxed state (SRX) of myosin in reconstituted full-length cardiac myosin thick filaments. We show that the presence of RLC fine-tunes the ability of myosin to form the SRX state and that its removal depopulates the SRX state. A similar reduction in SRX population is also achieved by phosphorylating the RLC with MLCK. The second mechanism of RLC-mediated regulation in muscle is thought to be by the binding of either Mg 2+ or Ca 2+ to the N-terminal EF-hand domain. Mg 2+ did not affect myosin SRX population, but increasing Ca 2+ enhanced the population of the myosin SRX state. Preliminary SRX studies on cardiomyopathy-causing RLC mutants R58Q (HCM), K104E (HCM) and D94A (DCM) show that none of the mutants affects the SRX population in the dephosphorylated state of the RLC; however these mutants also do not affect the SRX population when RLC is phosphorylated, unlike the wild-type. Additionally, in micro-scale thermophoresis binding experiments, only the dephosphorylated form of the DCM-causing D94A RLC mutant exhibits weaker binding to the myosin lever arm as compared to WT RLC. Binding of the mutants resembles WT upon phosphorylation. Altogether, these observations demonstrate that either RLC phosphorylation or Ca 2+ binding to RLC can alter the number of accessible myosin heads for contraction and cardiomyopathy-causing RLC mutants can modify this mechanism to varying extents.
Enantiodifferentiating functionalization of cis-cycloalkane-1,2-diols and cis-endo-5-norbornen-2,3-ylenebis(methanol) via chiral spiroacetals derived from L-menthone (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantiodifferentiating functionalization of cis-cycloalkane-1,2-diols and cis-endo-5-norbornen-2,3-ylenebis(methanol) via chiral spiroacetals derived from L-menthoneToshiro Harada, Isao Wada, and Akira OkuCite this: J. Org. Chem. 1989, 54, 11, 2599–2605Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/jo00272a027https://doi.org/10.1021/jo00272a027research-articleACS PublicationsRequest reuse permissionsArticle Views439Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Learning Semantic Textual Similarity from Conversations (2018)

We present a novel approach to learn representations for sentence-level semantic similarity using conversational data. Our method trains an unsupervised model to predict conversational input-response pairs. The resulting sentence embeddings perform well on the semantic textual similarity (STS) benchmark and SemEval 2017's Community Question Answering (CQA) question similarity subtask. Performance is further improved by introducing multitask training combining the conversational input-response prediction task and a natural language inference task. Extensive experiments show the proposed model achieves the best performance among all neural models on the STS benchmark and is competitive with the state-of-the-art feature engineered and mixed systems in both tasks.
Automatic Acquisition and Initialization of Kinematic Models (2001)

We extract and initialize kinematic models from monocular visual data from the ground up without any manual initialization, adaptation or prior model knowledge. Visual analysis, classification and tracking of articulated motion is challenging due to the difficulties involved in separating noise and spurious variability caused by appearance, size and view point fluctuations from the task-relevant variations. By incorporating powerful domain knowledge, model based approaches are able to overcome this problem to a great extent and are actively explored by many researchers. However, model acquisition, initialization and adaptation are still relatively underinvestigated problems. In this work we show how kinematic structure can be inferred from monocular views without making any a priori assumptions about the scene except that it consists of piecewise rigid segments constrained by jointed motion. The efficacy of the method is demonstrated on synthetic as well as natural image sequences.
Sintering of Si/sub 3/N/sub 4/. 15Y/sub 2/O/sub 3/ under high N/sub 2/ pressure (1979)

In the present study, pressureless sintering was conducted to determine if the same advantages could be obtained when Si/sub 3/N/sub 4/.15Y/sub 2/O/sub 3/ pellets under high N/sub 2/ pressure. This system was of interest because excellent ambient and high temperature properties had previously been obtained with hot-pressed samples. Some Si/sub 3/Y/sub 2/O/sub 3/N/sub 4/ (reported to be poor in oxidation resistance at 1000/sup 0/C) was present in the high density pellets, oxidation studies on these pellets at 1000/sup 0/C did not indicate any catastrophic oxidation behavior. At 1350/sup 0/C in air, the high density samples showed good oxidation resistance, with the rate of weight gain for the pellets decreasing with increasing density of the sample.
Support Measure Data Description (2014)

—We address the problem of learning a data description model for a dataset whose elements or observations are itself a set of points in R D . Modeling each observation as a probability measure, we describe such dataset by computing a minimum volume set for the probability measures, as means of a minimum enclosing ball of the representer functions of the probability measures in a Reproducing Kernel Hilbert Space (RKHS). The advantage is that we do not consider any particular form for the probability measures, instead, we use the embedding of such measures into a RKHS given by a positive definite kernel on probability measures. As a result, the data description model is a function that only depends on some probability measures: the support measures. We formulated three support measure data description models for such datasets: the optimization problem for the first one is a chance constrained program; the second is a direct extension of the support vector data description method to the case of probability measures; the third is the same as the second one, but defined for stationary kernels and scaling on data. We validate our method in the challenging task of group anomaly detection, with artificial and real datasets.
Joint Estimation of Camera Pose, Depth, Deblurring, and Super-Resolution from a Blurred Image Sequence (2017)

The conventional methods for estimating camera poses and scene structures from severely blurry or low resolution images often result in failure. The off-the-shelf deblurring or super-resolution methods may show visually pleasing results. However, applying each technique independently before matching is generally unprofitable because this naive series of procedures ignores the consistency between images. In this paper, we propose a pioneering unified framework that solves four problems simultaneously, namely, dense depth reconstruction, camera pose estimation, super-resolution, and deblurring. By reflecting a physical imaging process, we formulate a cost minimization problem and solve it using an alternating optimization technique. The experimental results on both synthetic and real videos show high-quality depth maps derived from severely degraded images that contrast the failures of naive multi-view stereo methods. Our proposed method also produces outstanding deblurred and super-resolved images unlike the independent application or combination of conventional video deblurring, super-resolution methods.
Determination of the Viability of Escherichia coli at the Single Organism Level by Electrorotation (1998)

If a bioparticle, such as a cell, bacterium, or virus, is exposed to an external electric field, it becomes electrically polarized. This polarization takes the form of electrical charges that are created on its external surface, as well as at the interfaces defining its internal structure. These field-induced charges lend to the bioparticle the properties of a large, electric dipole moment. The polarity and temporal orientation of this dipole, with respect to the applied field, depends on the dielectric properties of the suspending medium and the bioparticle (1) .

We used microelectrodes to create various forms of localized electric fields having frequencies covering the range from ∼100 Hz to 10 MHz. There are three principal types of AC fields: ( a ) a stationary, nonuniform field (1)(2)(3) that creates a dielectrophoretic force; ( b ) a traveling wave (1)(2)(3) that creates a dielectrophoretic force and a traveling wave force; and ( c ) a rotating field (4)(5) that creates rotational torque. The effects on the suspended bioparticles are, respectively, localized lateral motion, long-range lateral motion, and rotation (references are to the background theory and technology).

In the work reported here, rotating electric fields are used to investigate the binding of microorganisms to 6-μm diameter beads. In particular, we wished to determine whether electrorotation measurements are capable of detecting the viability of single Escherichia coli microorganisms attached to latex beads.

E. coli (K12) was obtained from the National Collection of Industrial and Marine Bacteria, Ltd., Aberdeen. Carboxylated latex beads of major axis 6 μm were obtained from Bangs Laboratories, and the polyclonal E. coli antibody was from Biogenesis. E. coli …
A randomized placebo‐controlled trial of preoperative tranexamic acid among women undergoing elective cesarean delivery (2015)

Preoperative administration of tranexamic acid safely reduces blood loss during elective lower-segment cesarean delivery. Australian New Zealand Clinical Trials Registry:ACTRN12615000312549.
Effects of halo implant on hot carrier reliability of sub-quarter micron MOSFETs (1998)

Halo implants with various tilt angles and energies were compared from the point of hot carrier reliability. Our study shows that a larger tilt or a deeper, more energetic halo implant leads to stronger reverse short channel effects and higher electric field in the extension/channel junction. However, the net impact of a sharper extension/channel junction on hot carrier degradation was found to be minimal, because the weaker halo devices have higher substrate current resulting from higher drain currents which counterbalances increased electric field in the extension-channel junction for the stronger halo devices. However, when devices from two lots with similar performance parametrics, such as similar threshold voltage (V/sub t/) roll-off, were compared, larger tilt/lower energy halo devices were found to have less degradation than lower tilt/higher energy halos.
Spatial Correlation of High Density EMG Signals Provides Features Robust to Electrode Number and Shift in Pattern Recognition for Myocontrol (2014)

Research on pattern recognition for myoelectric control has usually focused on a small number of electromyography (EMG) channels because of better clinical acceptability and low computational load with respect to multi-channel EMG. However, recently, high density (HD) EMG technology has substantially improved, also in practical usability, and can thus be applied in myocontrol. HD EMG provides several closely spaced recordings in multiple locations over the skin surface. This study considered the use of HD EMG for controlling upper limb prostheses, based on pattern recognition. In general, robustness and reliability of classical pattern recognition systems are influenced by electrode shift in dons and doff, and by the presence of malfunctioning channels. The aim of this study is to propose a new approach to attenuate these issues. The HD EMG grid of electrodes is an ensemble of sensors that records data spatially correlated. The experimental variogram, which is a measure of the degree of spatial correlation, was used as feature for classification, contrary to previous approaches that are based on temporal or frequency features. The classification based on the variogram was tested on seven able-bodied subjects and one subject with amputation, for the classification of nine and seven classes, respectively. The performance of the proposed approach was comparable with the classic methods based on time-domain and autoregressive features (average classification accuracy over all methods ∼ 95% for nine classes). However, the new spatial features demonstrated lower sensitivity to electrode shift ( ± 1 cm) with respect to the classic features . When even just one channel was noisy, the classification accuracy dropped by ∼ 10% for all methods. However, the new method could be applied without any retraining to a subset of high-quality channels whereas the classic methods require retraining when some channels are omitted. In conclusion, the new spatial feature space proposed in this study improved the robustness to electrode number and shift in myocontrol with respect to previous approaches.
기업의 무형자산이 기업가치에 미치는 영향에 관한 연구 : 코스닥 상장 중견기업을 중심으로 (2016)

최근 들어 정책적으로 과학기술에 대한 비중이 커짐에 따라 정부와 기업의 연구개발 투자도 증가 하고 있다. 특히 기업의 성과 측면에 대한 요구도 커져가고 있으며, 체계적인 연구개발투자를 통해 지적재산권 창출을 하려는 노력이 이루어지고 있다. 그 중에서도 특허는 기업의 기술경쟁력 우위를 획득하고 기술을 보호받...