gebhart/patrepeval huggingface dataset:
Active and passive immunization for atherosclerosis. (2007)

This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Inmmunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious optimism remains that a vaccine-based approach has the potential to become a part of the armamentarium for atherosclerotic vascular disease.
A Novel Shearing Interferometer with Direct Display of Lens Lateral Aberrations (1995)

We describe a new shearing interferometer for lens testing which has high precision and direct display of lens aberrations. Shear is obtained by reflecting a wavefront collimated by the lens under test from the front and rear surfaces of a wedged glass plate. The surfaces of the plate are coated to increase their reflection coefficient and give sharp multiple beam interference fringes which are easy to measure and interpret. We show mathematically that the interference fringes map out the lateral aberration curve of the lens under test directly, and present experimental results which display the advantages of this system over conventional two-beam shearing interferometers.
Monitoring Carbon Dioxide Floods Using Electrical Resistance Tomography (ERT): Sensitivity Studies (2003)

We have conducted a numerical and physical modeling study to evaluate the sensitivity of electrical resistance tomography (ERT) to electrical resistivity changes caused by CO2 injection and sequestration in geologic reservoirs. We chose the Maljamar CO2 flood (pilot study) as a basis for our numerical modeling study. We also constructed physical models consisting of blocks of various materials inserted in a water tank to evaluate some of the conclusions of the numerical study. This study quantifies the effects of a variety of factors that affect the resolution and accuracy of the ERT method, under realistic conditions of scale, contrast, and measurement error. It considers scenarios where vertical arrays of point electrodes are used and where metal-cased boreholes are used as long electrodes. Long electrode tomographs provide information such as the shape, location, and lateral extent of the flood. When point electrode arrays or horizontal wells are available, the approximate vertical extent of the flood and coarse estimates of sequestered CO2 volume may be deduced. Results from physical models support trends observed in the numerical study. Based on this study, we suggest that the ERT method can help confirm the containment of CO2.
Evaluation of a new simple collection device for sampling of microparticles in exhaled breath (2018)

The microparticle fraction of exhaled breath is of interest for developing clinical biomarkers. Exhaled particles may contain non-volatile components from all parts of the airway system, formed during normal breathing. This study aimed to evaluate a new, simple sampling device, based on impaction, for collecting microparticles from exhaled breath. Performance of the new device was compared with that of the existing SensAbues membrane filter device. The analytical work used liquid chromatography-tandem mass spectrometry methods. The new device collected three subsamples and these were separately analysed from eight individuals. No difference was observed between the centre position (0.91 ng/sample) and the side positions (1.01 ng/sample) using major phosphatidylcholine (PC) 16:0/16:0 as the analyte. Exhaled breath was collected from eight patients on methadone maintenance treatment. The intra-individual variability in measured methadone concentration between the three collectors was 8.7%. In another experiment using patients on methadone maintenance treatment, the sampling efficiency was compared with an established filter device. Compared to the existing device, the efficiency of the new device was 121% greater for methadone and 1450% greater for DPPC. The data from lipid analysis also indicated that a larger fraction of the collected material was from the distal parts. Finally, a study using an optical particle counter indicated that the device preferentially collects the larger particle fraction. In conclusion, this study demonstrates the usefulness of the new device for collecting non-volatile components from exhaled breath. The performance of the device was superior to the filter device in several aspects.
Studies on the common active site of growth hormone. Revision of the amino acid sequence of an active fragment of bovine growth hormone. (1975)

A fragment, A-II, isolated from a component of a tryptic digest of bovine growth hormone has growth-promoting activity in rats and metabolic activity in humans similar to human growth hormone. The amino acid sequence of this peptide has been reinvestigated and revised. The 38-amino acid peptide was cleaved with cyanogen bromide, chymotrypsin, and trypsin. The amino acid sequences were then established by Edman degradation as well as with overlapping peptides; Homology in the sequence was good between this bovine growth hormone fragment and peptides occurring in ovine growth hormone, human growth hormone, and human chorionic somatomammotropin.
Ultra low PMD fibers by fiber spinning (2004)

This paper reviews fiber spinning technology for making low PMD fibers. Theoretical understanding of fiber spinning mechanism and features of spun fibers, as well as applications in fiber spin profile designs are discussed.
Data Handling Algorithms For Autonomous Shingled Magnetic Recording HDDs (2012)

The acceptance of shingled magnetic recording (SMR) drives in the marketplace depends in part upon their system performance with the operational constraints demanded by SMR's wide writing heads. Current thinking suggests that SMR may require significant changes to the host file system because of SMR's natural proclivity for sequential writing, and supposed difficulty with random write operations. In this work, we propose a data handling algorithm which exhibits good short-block sustained random write performance. In addition, we examine optimal algorithms for intermediate transfer lengths on the order of one physical track in length.
Study of CYP2D6 gene in children with autoimmune hepatitis and P450 IID6 autoantibodies (1992)

Cytochrome P450 IID6 is an autoantigen recognized by the sera of children affected with a subtype of autoimmune hepatitis. It was hypothesized that a mutation in the CYP2D6 gene could explain the autoimmune response in these patients. To examine this question, genomic DNA from peripheral lymphocytes (n = 9) and liver (n = 1) of 10 patients with anti-LKM-1 antibody was analysed by Southern blot for genetic association studies between a particular CYP2D6 haplotype and autoimmune hepatitis. In addition, a region of CYP2D6, from the same genomic DNA, was amplified by polymerase chain reaction (PCR) and digested by BstNI, in a search for the most prevalent 29B mutation, described in subjects who do not express the P450 IID6. Total RNA and proteins, prepared from the liver of an anti-LKM-1+ patient, were analysed by Northern and Western (immunoblot) blots respectively. Our results do not reveal any major structural change in the DNA of this patient at the CYP2D6 locus that could explain their autoimmune response. Corroborating this observation, no changes were noted either in P450 IID6 mRNA size or in the corresponding protein. However, these data do not exclude the possibility of subtle changes in the protein due to point mutations in critical regions that might trigger an autoimmune response.
Large scale phased array calibration (2016)

We describe a new method for calibrating large phased arrays, namely the Mobile Fourier Gauge (MFG), that permits rapid calibration of large phased arrays on site, and removes the need for expensive near field facility testing. This calibration method has been demonstrated on a large S-Band phased array, and its accuracy validated.
Cellular fatty acid synthase is required for late stages of HIV-1 replication (2017)

Here we show that HIV-1 replication both increases FASN levels and requires host FASN activity. We also report that Fasnall, a novel FASN inhibitor that demonstrates anti-tumor activity in vivo, is a potent and efficacious antiviral, blocking HIV-1 replication in both tissue culture and primary cell models of HIV-1 replication. In adults, most fatty acids are obtained exogenously from the diet, thus making FASN a plausible candidate for pharmacological intervention. In conclusion, we hypothesize that FASN is a novel host dependency factor and that inhibition of FASN activity has the potential to be exploited as an antiretroviral strategy.
Identification of noncytopathic equine rhinovirus 1 as a cause of acute febrile respiratory disease in horses (1997)

Equine rhinovirus 1 (ERhV1) is a recognized cause of acute febrile respiratory disease in horse, although the virus is rarely isolated from such animals, despite seroprevalence rates as high as 50% in some horse populations. Recently, ERhV1 has been shown to be most closely related to foot-and-mouth disease virus, raising questions as to its disease associations in horses. We report that ERhV1 infection was the likely cause of two separate outbreaks of severe febrile respiratory disease which involved more than 20 horses. Attempts to isolate ErhV1 from nasopharyngeal swabs by conventional cell culture methods were unsuccessful, in that cytopathology was not observed. Viral antigen was detected by immunofluorescence assay in the cytoplasm of cells infected with 10 of 15 nasopharyngeal swab samples, indicating the presence and presumably replication of ERhV1. A rise in serum neutralizing antibody titer between acute- and convalescent-phase sera confirmed that ERhV1 was causatively associated with one of the outbreaks. ERhV1 RNA was detected in nasopharyngeal swabs collected from all horses during the acute phase of disease by reverse transcription-PCR. Nucleotide sequencing of amplified products showed that within each outbreak a single strain of ERhV1 was involved but that distinct viruses were involved in each outbreak. A retrospective study of samples from nine other outbreaks of respiratory disease in horses suggested ERhV1 etiology in at least two of these. We conclude that the relative importance of ERhV1 as a cause of acute febrile respiratory disease in horses has been underestimated due to failure in many instances to isolate virus by conventional cell culture methods.
Liquid lens confocal microscopy with advanced signal processing for higher resolution 3D imaging (2009)

The paper first highlights the use of multiple electronically controlled optical lenses, specifically, liquid lenses to realize an axial scanning confocal microscope with potentially less aberrations. Next, proposed is a signal processing method for realizing high resolution three dimensional (3-D) optical imaging using diffraction limited low resolution optical signals. Using axial shift-based signal processing via computer based computation algorithm, three sets of high resolution optical data is determined along the axial (or light beam propagation) direction using low resolution axial data. The three sets of low resolution data are generated by illuminating the 3-D object under observation along its three independent and orthogonal look directions (i.e., x, y, and z) or by physically rotating the object by 90 degrees and also flipping the object by 90 degrees. The three sets of high resolution axial data is combined using a unique mathematical function to interpolate a 3-D image of the test object that is of much higher resolution than the diffraction limited direct measurement 3-D resolution. Confocal microscopy or optical coherence tomography (OCT) are example methods to obtain the axial scan data sets. The proposed processing can be applied to any 3-D wave-based 3-D imager including ones using electromagnetic waves and sound (ultrasonic) waves. Initial computer simulations are described to test the robustness of the proposed high resolution signal processing method.
Revocable fingerprint biotokens: accuracy and security analysis (2007)

This paper reviews the biometric dilemma, the pending threat that may limit the long-term value of biometrics in security applications. Unlike passwords, if a biometric database is ever compromised or improperly shared, the underlying biometric data cannot be changed. The concept of revocable or cancelable biometric-based identity tokens (biotokens), if properly implemented, can provide significant enhancements in both privacy and security and address the biometric dilemma. The key to effective revocable biotokens is the need to support the highly accurate approximate matching needed in any biometric system as well as protecting privacy/security of the underlying data. We briefly review prior work and show why it is insufficient in both accuracy and security. This paper adapts a recently introduced approach that separates each datum into two fields, one of which is encoded and one which is left to support the approximate matching. Previously applied to faces, this paper uses this approach to enhance an existing fingerprint system. Unlike previous work in privacy-enhanced biometrics, our approach improves the accuracy of the underlying svstem! The security analysis of these biotokens includes addressing the critical issue of protection of small fields. The resulting algorithm is tested on three different fingerprint verification challenge datasets and shows an average decrease in the Equal Error Rate of over 30% - providing improved security and improved privacy.
Porphyrins Bearing Arylphosphonic Acid Tethers for Attachment to Oxide Surfaces (2003)

Synthetic molecules bearing phosphonic acid groups can be readily attached to oxide surfaces. As part of a program in molecular-based information storage, we have developed routes for the synthesis of diverse porphyrinic compounds bearing phenylphosphonic acid tethers. The routes enable (1) incorporation of masked phosphonic acid groups in precursors for use in the rational synthesis of porphyrinic compounds and (2) derivatization of porphyrins with masked phosphonic acid groups. The precursors include dipyrromethanes, monoacyldipyrromethanes, and diacyldipyrromethanes. The tert-butyl group has been used to mask the dihydroxyphosphoryl substituent. The di-tert-butyloxyphosphoryl unit is stable to the range of conditions employed in syntheses of porphyrins and multiporphyrin arrays yet can be deprotected under mild conditions (TMS-Cl/TEA or TMS-Br/TEA in refluxing CHCl(3)) that do not cause demetalation of zinc or magnesium porphyrins. The porphyrinic compounds that have been prepared include (1) A(3)B-, trans-AB(2)C-, and ABCD-porphyrins that bear a single phenylphosphonic acid group, (2) a trans-A(2)B(2)-porphyrin bearing two phenylphosphonic acid groups, (3) a chlorin that bears a single phenylphosphonic acid group, and (4) a porphyrin dyad bearing a single phenylphosphonic acid group. For selected porphyrin-phosphonic acids, the electrochemical characteristics have been investigated for molecules tethered to SiO(2) surfaces grown on doped Si. The voltammetric behavior indicates that the porphyrin-phosphonic acids form robust, electrically well-behaved monolayers on the oxide surface.
Monolayer Stress Microscopy: Limitations, Artifacts, and Accuracy of Recovered Intercellular Stresses (2013)

In wound healing, tissue growth, and certain cancers, the epithelial or the endothelial monolayer sheet expands. Within the expanding monolayer sheet, migration of the individual cell is strongly guided by physical forces imposed by adjacent cells. This process is called plithotaxis and was discovered using Monolayer Stress Microscopy (MSM). MSM rests upon certain simplifying assumptions, however, concerning boundary conditions, cell material properties and system dimensionality. To assess the validity of these assumptions and to quantify associated errors, here we report new analytical, numerical, and experimental investigations. For several commonly used experimental monolayer systems, the simplifying assumptions used previously lead to errors that are shown to be quite small. Out-of-plane components of displacement and traction fields can be safely neglected, and characteristic features of intercellular stresses that underlie plithotaxis remain largely unaffected. Taken together, these findings validate Monolayer Stress Microscopy within broad but well-defined limits of applicability.
A Synthetic Linear Decapeptide Binds to the Atrial Natriuretic Peptide Receptors and Demonstrates Cyclase Activation and Vasorelaxant Activity (1989)

A linear decapeptide, [cyclohexylalanine 106]ANP-(105-114)NH2 (1), where ANP is atrial natriuretic peptide, was prepared by solid phase synthesis and purified by reverse-phase liquid chromatography. This novel peptide was found to bind to ANP receptors in rabbit lung membranes, to stimulate cGMP production in various tissues, and to fully relax precontracted rabbit aorta in a dose-dependent fashion. The potency of 1 in the various in vitro assays varies between one-twentieth and one-eightieth of the potency of the reference peptide, the 24-mer rat ANP-(103-126). The linear decapeptide 1, which encompasses amino acid residues from the rat ANP sequence (105-114), features a cyclohexylalanine residue instead of the phenylalanine 106 residue in the hormone sequence, a free sulfhydryl function at the N-terminal cysteine 105, and a carboxamide C terminus. Its disulfide dimer 6 was active in the rabbit aorta assay while the S-methyl cysteine 7 analogue was not active in the same assay at similar concentrations. The decapeptide 1 is of particular significance because it is the shortest analogue reported to date endowed with agonistic activity at the guanylate cyclase-coupled ANP receptor. In particular, it is interesting to compare its structure to the structures of other short linear analogues of ANP which are totally devoid of the ability to stimulate particulate guanylate cyclase activity.
Axial ligands and alicyclic ring size modulate the activity and biochemical pharmacology of ammine/cycloalkylamine-platinum(IV) complexes in tumor cells resistant to cis-diamminedichloroplatinum(II) or trans-1R,2R-1S,2S-diaminocyclohexanetetrachloroplatinum(IV). (1994)

A platinum(II) and 3 platinum(IV) ammine/cycloalkylamine homologous series were evaluated for cytotoxicity and biochemical pharmacology in murine leukemia L1210/0, cis-diamminedichloroplatinum(II)- resistant L1210/DDP, and diaminocyclohexaneplatinum-resistant L1210/1,2-diaminocyclohexane (DACH) cells. Within each series, which contained 4 homologues with differing alicyclic (cycloalkyl) ring size (cyclopropane, cyclobutane, cyclopentane, or cyclohexane), cytotoxicity increased with increasing ring size. This appeared to be due to an increase in partition coefficient, and the resulting increase in drug accumulation and intracellular DNA adducts in ascending each of the series. There were exceptions to this generalization, predominantly in L1210/DACH cells, where the biochemical pharmacology was not entirely consistent with the cytotoxic response and suggested that other factors may be at play. The relationship between structure and ability to circumvent cis-diamminedichloroplatinum(II) and/or trans-1R,2R-1S,2S- diaminocyclohexanetetrachloroplatinum(IV) resistance was complex. Ascending the platinum(II) series caused resistance factors to decrease in L1210/DDP cells but increase in L1210/DACH cells. An increase in resistance factors was also observed in ascending the axial chloroplatinum(IV) series in the L1210/DACH line. In contrast, ascending the axial chloroplatinum(IV) series in the L1210/DDP line and axial acetatoplatinum(IV) and axial hydroxoplatinum(IV) series in both cell lines resulted in increases in resistance factors for the first stepwise increase in the cycloalkylamine ring size, but resistance factors then decreased progressively with further increases in ring size. Reduction of the platinum(IV) analogues to the platinum(II) congener appears to be necessary for binding to DNA. The similarity in biological actions between the platinum(II) and axial chloroplatinum(IV) series is likely due to the rapid reduction of tetravalent members to platinum(II) forms. The axial acetatoplatinum(IV) and axial hydroxoplatinum(IV) complexes were reduced more slowly, which may explain their lower potency, but not the ability of the higher member to circumvent both cis-diamminedichloroplatinum(II) and trans-1R,2R-1S,2S- diaminocyclohexanetetrachloroplatinum(IV) resistances. Explanation for this will require additional studies. The results have demonstrated high dependencies on ring size of the carrier amine ligand, valence state of platinum, and the nature of the axial ligand for modulation of potency, cross-resistance property, and biochemical pharmacology of ammine/cycloalkylamine complexes.
Cooling Technology for the Optical Disc Drive using Air-flow induced by Disc Rotation (2006)

Recently, data transfer rates of optical disc drives have been dramatically increasing. To obtain the high data transfer rates, disc rotation speed and laser power also need to be increased. Therefore, to develop the next generation optical disc drives effectively, enhanced cooling system of the optical pick-up unit which includes the laser diode is indispensable. The cooling performance of the pick-up unit is directly influenced by the inside airflow induced by the disc rotation. Tb maximize the effect of the airflow around the pick-up unit, we applied the combination of PIV (Particle Image Velocimetry) and CFD (Computational Fluid Dynamics) simulation. It was made clear that the tray opening near the pick-up unit increased the cooling performance effectively.
Experimental immunisation of lambs against pneumonic pasteurellosis. (1983)

Methods of immunising lambs against pneumonic pasteurellosis, caused by several serotypes of Pasteurella haemolytica, were assessed in specific pathogen free lambs. Lambs were vaccinated intramuscularly with sodium salicylate extract (SSE) of P haemolytica, either alone or in combination with heat-killed organisms (HKO). SSE of P haemolytica type A1 protected vaccinated lambs against pneumonia resulting from challenge with the homologous serotype. SSE of type A2 also provided some protection but this was improved by vaccination with a combination of SSE and HKO.
Fuzzy logic data analysis of environmental data for traffic control (2002)

Traffic control is based on the analysis of traffic detection and environmental conditions. Especially bad environmental conditions are a hazard to car drivers. In this paper fuzzy technologies are used to analyze environmental conditions like road surface, visual range and weather conditions detected by local stations and road sensors. Because of the fact that detection of environmental conditions is uncertain, conventional approaches are unsuitable in a certain evaluation and analysis of the given signals detected by the available equipment. The fuzzy solution takes the diversified equipment of the different detection stations into account, uses a two step plausibility check to determine the quality of sensor signals, computes substitute values as long as comparable sensors are in use and leads to more appropriate results for the evaluation of road surface condition and visual range to indicate slippery road or fog warning. The solution was developed for an existing traffic control system of the B27, a state highway between Stuttgart city, Stuttgart airport and Tubingen, Germany. The unit is part of a complete fuzzy logic traffic control system. Implementations in several other systems are scheduled.