gebhart/patrepeval huggingface dataset:
High power continuous and quasi-continuous waveInGaAsP/InP broad-waveguide separate confinement-heterostructuremultiquantum well diode lasers (1997)

The application of the broad-waveguide concept to InGaAsP/InP diode lasers has resulted in a fourfold reduction in internal loss to 1.3 cm–1 while achieving a record low threshold current of 73 A/cm2 per quantum well. Output powers of 5.2 W continuous wave and 10 W quasi-continuous wave are demonstrated for 200 µm-aperture lasers emitting at 1.43 µm.
Limited Protection Conferred by Recombinant Newcastle Disease Virus Expressing Infectious Bronchitis Spike Protein (2019)

Recombinant Newcastle disease virus (NDV) LaSota (LS) expressing secreted trimeric spike (S)-ectodomain (Se) of infectious bronchitis virus (IBV) (rLS/IBV.Se) was developed and evaluated for protection conferred against IBV challenge. The IBV S-ectodomain protein, which is S excluding the transmembrane anchor and short cytoplasmic domain of S2, expressed from recombinant LS corresponds to an Arkansas (Ark)-type IBV. In a first experiment, chickens were primed at 1 day of age or primed at 1 day of age and boosted at 14 days of age with 10<sup>4</sup> 50% embryo infectious doses (EID<sub>50</sub>)/bird of rLS/IBV.Se and challenged with a virulent Ark strain. A single vaccination proved completely ineffective at protecting chickens against challenge, whereas priming and boosting reduced clinical signs and tracheal lesions but did not reduce viral load in lachrymal fluids. In experiment 2, the vaccine dose was increased to 10<sup>7</sup> EID<sub>50</sub>/bird and a different virulent Ark strain was used for challenge. In addition, chickens were singly immunized on either day 1 or day 10 after hatch. NDV antibody levels detected in vaccinated chickens were moderate, with hemagglutination inhibition titers varying between 4 and 5 log<sub>2</sub>. Slightly higher antibody levels to NDV were observed in chickens vaccinated on day 10 versus day 1 but without the difference achieving statistical significance. In contrast, antibody responses measured using recombinant IBV S1 protein-coated ELISA plates were significantly greater in chickens vaccinated on day 10 than on day 1. The use of a higher rLS/IBV.Se dose substantially enhanced the success of a single vaccination compared to experiment 1. Signs and tracheal lesions were reduced more effectively in chickens vaccinated at day 10 after hatch. However, as in experiment 1, vaccination did not reduce the viral loads in tear fluids of challenged chickens. Similar results, in which no reduction in viral load in the trachea was apparent from rLS/IBV.S vaccination, have been obtained by others. Further work is needed to understand the immune responses induced by this recombinant virus that seems to provide some protection against the disease but does not reduce viral loads in the upper respiratory tract.
Neural Face Editing with Intrinsic Image Disentangling (2017)

Traditional face editing methods often require a number of sophisticated and task specific algorithms to be applied one after the other - a process that is tedious, fragile, and computationally intensive. In this paper, we propose an end-to-end generative adversarial network that infers a face-specific disentangled representation of intrinsic face properties, including shape (i.e. normals), albedo, and lighting, and an alpha matte. We show that this network can be trained on “in-the-wild” images by incorporating an in-network physically-based image formation module and appropriate loss functions. Our disentangling latent representation allows for semantically relevant edits, where one aspect offacial appearance can be manipulated while keeping orthogonal properties fixed, and we demonstrate its use for a number offacial editing applications.
Encapsulation of metal nanocluster catalysts in silica materials via an inverse micelle/sol-gel synthesis (1997)

Nanometer sized metal particles were encapsulated in the micropores of xerogels and aerogels. The synthesis involves the sequential reduction of a metal salt followed by sol-gel processing in an inverse micelle solution. The inverse micelle solution solubilizes the metal salt and provides a micro-reactor for the nucleation, growth, and stabilization of the nanometer sized clusters. Hydrolysis and condensation of an added siloxane precursor produces a wet gel embedding the particles. Characterization of the particle size and composition and the particle growth process was completed with transmission electron microscopy (TEM), electron diffraction, and UV-visible absorption spectrometry. Characterization of the gel surface areas was completed with N{sub 2} porosimetry. Material properties determined as a function of the gel precursor (TEOS vs. a pre-hydrolyzed form of TEOS), the water to gel precursor reaction stoichiometry, and surfactant concentration are discussed in terms of the unique solution chemistry occurring in the micro-heterogeneous inverse micelle solutions. Finally, catalyst development and catalyst activity of the materials are discussed. 1-hexene hydrogenation was chosen as a model reaction.
Photoinduced Charge Transfer between CdSe Nanocrystal Quantum Dots and Ru−Polypyridine Complexes (2006)

In this communication, we demonstrate a new approach to sensitization of Ru-polypyridine complexes by using semiconductor nanocrystal quantum dots (NQDs). When mixed in solution, the complexes functionalized by carboxylic groups adsorb onto the surface of the NQDs. Excitation of NQDs by 400 nm light leads to fast, 5 ps hole transfer from the photoexcited NQDs to the surface-adsorbed complexes. This result indicates that Ru complexes can be sensitized by CdSe NQDs, which opens interesting opportunities for designing new types of photocatalytic materials for solar energy conversion applications. These materials will take advantage of broad size-controlled absorption spectra and large extinction coefficients of NQDs as well as the unique property of NQDs to respond to absorption of a single photon by producing multiple electron-hole pairs.
Lattice light sheet microscopy using tiling lattice light sheets (2019)

We present a novel method used to implement tiling lattice light sheets (LLS) in lattice light sheet microscopy (LLSM) on regular LLS microscopes without changing the LLS microscope hardware. A LLS is tiled by applying binary phase maps acquired from off-center cross-sections of the corresponding optical lattice to the binary SLM used in LLS microscopes, by which a thin LLS can be tiled to image large specimens while maintaining the 3D imaging ability in the entire field of view. We investigate the method via numerical simulations and experiments, and demonstrate the method by imaging fluorescent particles embedded in agarose gel and expanded cells in the dithered mode of LLSM.
A Dual-Input Two-Box Model for Digital Predistortion of Envelope Tracking Power Amplifiers (2016)

This work proposes a novel two-box dual-input single-output digital predistorter (labeled as the LUT MISO predistorter) suitable for linearizing dynamic nonlinear envelope tracking power amplifiers. The LUT MISO predistorter is built by cascading a single-input memoryless nonlinear function with a two-input polynomial model with memory. The predistorted signal is synthesized as a function of the baseband complex waveform as well as the corresponding envelope-shaped signal. The LUT MISO predistorter is experimentally benchmarked against its single-box dual-input counterpart. It is shown that for the same number of coefficients, reduced spectrum regrowth and better adjacent channel power ratio were obtained with the LUT MISO predistorter. Moreover, the proposed predistorter was found to pass the ACPR requirements of the LTE standard while its conventional counterpart fails.
Chemically Stable Proton Conducting Doped BaCeO3 -No More Fear to SOFC Wastes (2013)

Development of chemically stable proton conductors for solid oxide fuel cells (SOFCs) will solve several issues, including cost associated with expensive inter-connectors and long-term durability. Best known Y-doped BaCeO3 (YBC) proton conductors-based SOFCs suffer from chemical stability under SOFC by-products including CO2 and H2O. Here, for the first time, we report novel perovskite-type Ba0.5Sr0.5Ce0.6Zr0.2Gd0.1Y0.1O3−δ by substituting Sr for Ba and co-substituting Gd + Zr for Ce in YBC that showed excellent chemical stability under SOFC by-products (e.g., CO2 and H2O) and retained a high proton conductivity, key properties which were lacking since the discovery of YBCs. In situ and ex- situ powder X-ray diffraction and thermo-gravimetric analysis demonstrate superior structural stability of investigated perovskite under SOFC by-products. The electrical measurements reveal pure proton conductivity, as confirmed by an open circuit potential of 1.15 V for H2-air cell at 700°C and merits as electrolyte for H-SOFCs.
New method to determine shear absorption using the viscoelastodynamic resonance-scattering formalism (1978)

We have recently developed a new resonance theory for the scattering of compressional waves by fluid-filled spherical cavities in viscoelastic materials, and have applied it to the study of the resonance frequencies and widths of peaks in the (monopole) fpp0 scattering amplitude. Using this theory, which is the viscoelastodynamical counterpart of the Breit–Wigner formalism of nuclear scattering theory, we find that (i) the relative half-width of the peaks depends linearly on the resonance frequency, (ii) the shear-absorption parameter of the viscoelastic material containing the cavity can be determined from the slope of a straight line fit to the data. This determination is possible precisely because our theory realistically accounts for absorption in the material, and thus its predictions compare favorably with experimentally measured data. Finally, the theory gives a self-consistent way to verify the weak absorption assumption inherent in the prediction.
Indirect Detection of Nitrogen‐14 in Solid‐State NMR Spectroscopy (2007)

NMR spectra of (14)N (spin I=1) are obtained by indirect detection in powders spinning at the magic angle. The method relies on the transfer of coherence from a neighboring "spy" nucleus with S=1/2, such as (13)C or (1)H, to single- or double-quantum transitions of (14)N nuclei. The transfer of coherence can occur through a combination of scalar and residual dipolar splittings (RDS); the latter are also known as second-order quadrupole-dipole cross terms. The two-dimensional NMR spectra reveal powder patterns determined by second- and third-order quadrupolar couplings. These spectra depend on the quadrupolar coupling constant C(Q) (typically a few megahertz), on the asymmetry parameter eta(Q) of the (14)N nucleus, and on the orientation of the internuclear vector r(IS) between the I ((14)N) and S (spy) nuclei with respect to the quadrupolar tensor. These parameters, which can be subject to motional averaging, can reveal valuable information about the structure and dynamics of nitrogen-containing solids. Application of this technique to various amino acids, either enriched in (13)C or with natural carbon isotope abundance, with spectra recorded at various magnetic fields, illustrates the scope of the method.
Dual-Purpose Spectrum Sensor Using IEEE802.15.4a UWB PHY and Energy Detection (2009)

Cognitive radio(CR) has become an enabling technology to realize dynamic spectrum access through its spectrum sensing and reconfigurable capability. Robust and reliable spectrum sensing is needed to discover spectrum opportunity. Single cognitive radios often fail to provide such reliable information due to their inherent sensitivity limitation. Primary signals that are subject to detection by cognitive radios may become weak due to several factors such as fading and shadowing. One approach to alleviate this problem is to perform the spectrum sensing by using multiple CRs or multiple spectrum sensors. This approach known as distributed sensing because sensing is carried out through cooperation of spatially distributed sensors. In distributed sensing, sensors should perform spectrum sensing and forward the result to a destination where data fusion is carried out. In this paper we introduce a concept of a dual-purpose spectrum sensor that can combine the sensing and communication functions. The dual-purpose sensor reuses its detection hardware for both functions resulting in a less hardware complexity. We consider IEEE802.15.4a UWB PHY for communication and energy detection for spectrum sensing.
Up-Scaling Graphene Electronics by Reproducible Metal–Graphene Contacts (2015)

Chemical vapor deposition (CVD) of graphene on top of metallic foils is a technologically viable method of graphene production. Fabrication of microelectronic devices with CVD grown graphene is commonly done by using photolithography and deposition of metal contacts on top of the transferred graphene layer. This processing is potentially invasive for graphene, yields large spread in device parameters, and can inhibit up-scaling. Here we demonstrate an alternative process technology in which both lithography and contact deposition on top of graphene are prevented. First a prepatterned substrate is fabricated that contains all the device layouts, electrodes and interconnects. Then CVD graphene is transferred on top. Processing parameters are adjusted to yield a graphene layer that adopts the topography of the prepatterned substrate. The metal-graphene contact shows low contact resistances below 1 kΩ μm for CVD graphene devices. The conformal transfer technique is scaled-up to 150 mm wafers with statistically similar devices and with a device yield close to unity.
Spin-transfer switching in MgO-based magnetic tunnel junctions (invited) (2006)

We present spin-transfer switching results for MgO-based magnetic tunneling junctions (MTJs) with large tunneling magnetoresistance ratio of up to 150% and low intrinsic switching current density (Jc0) of (2–3)×106A∕cm2. The low intrinsic switching current density is attributed to high tunneling spin polarization (TSP) in MgO-based MTJs. The current switching data are discussed based on a qualitative study of TSP in MgO-based MTJs. Additional film stack modification needed to decrease the switching current to meet the requirement of advanced magnetoresistive random access memory application is also discussed.
Decontamination of the Skin with Absorbing Materials (2010)

Stimulation of the penetration of topically applied substances into the skin is a topic of intensive dermatological and pharmacological research. Next to intercellular penetration, i.e. a penetration inside the lipid layers around the corneocytes, follicular penetration also represents an efficient penetration pathway. The hair follicles act as a long-term reservoir for topically applied substances. They are surrounded by or contain several important target structures, such as blood capillaries, stem cells and dendritic cells. Therefore, the hair follicles have to be well protected from hazardous substances coming into contact with the skin. The traditional method of decontamination of the skin involves an intensive washing procedure. However, this process represents a massage, which pushes the hazardous substances even deeper into the hair follicles. In the present study, the application of absorbing materials for decontamination of the skin was investigated after the application of a model substance utilizing the tape-stripping procedure. It was found that absorbing materials are better suited than the washing process for decontamination of the skin.
Discriminative Non-blind Deblurring (2013)

Non-blind deblurring is an integral component of blind approaches for removing image blur due to camera shake. Even though learning-based deblurring methods exist, they have been limited to the generative case and are computationally expensive. To this date, manually-defined models are thus most widely used, though limiting the attained restoration quality. We address this gap by proposing a discriminative approach for non-blind deblurring. One key challenge is that the blur kernel in use at test time is not known in advance. To address this, we analyze existing approaches that use half-quadratic regularization. From this analysis, we derive a discriminative model cascade for image deblurring. Our cascade model consists of a Gaussian CRF at each stage, based on the recently introduced regression tree fields. We train our model by loss minimization and use synthetically generated blur kernels to generate training data. Our experiments show that the proposed approach is efficient and yields state-of-the-art restoration quality on images corrupted with synthetic and real blur.
In vivo imaging of CT26 mouse tumours by using cmHsp70.1 monoclonal antibody (2010)

The major stress-inducible heat shock protein 70 (Hsp70) is frequently present on the cell surface of human tumours, but not on normal cells. Herein, the binding characteristics of the cmHsp70.1 mouse monoclonal antibody (mAb) were evaluated in vitro and in a syngeneic tumour mouse model. More than 50% of the CT26 mouse colon carcinoma cells express Hsp70 on their cell surface at 4°C. After a temperature shift to 37°C, the cmHsp70.1-fluorescein isothiocyanate mAb translocates into early endosomes and lysosomes. Intraoperative and near-infrared fluorescence imaging revealed an enrichment of Cy5.5-conjugated mAb cmHsp70.1, but not an identically labelled IgG1 isotype-matched control, in i.p. and s.c. located CT26 tumours, as soon as 30 min. after i.v. injection into the tail vein. Due to the rapid turnover rate of membrane-bound Hsp70, the fluorescence-labelled cmHsp70.1 mAb became endocytosed and accumulated in the tumour, reaching a maximum after 24 hrs and remained detectable at least up to 96 hrs after a single i.v. injection. The tumour-selective internalization of mAb cmHsp70.1 at the physiological temperature of 37°C might enable a targeted uptake of toxins or radionuclides into Hsp70 membrane-positive tumours. The anti-tumoral activity of the cmHsp70.1 mAb is further supported by its capacity to mediate antibody-dependent cytotoxicity.
Magnetic resonance elastography: Inversions in bounded media (2009)

Magnetic resonance elastography is a noninvasive imaging technique capable of quantifying and spatially resolving the shear stiffness of soft tissues by visualization of synchronized mechanical wave displacement fields. However, magnetic resonance elastography inversions generally assume that the measured tissue motion consists primarily of shear waves propagating in a uniform, infinite medium. This assumption is not valid in organs such as the heart, eye, bladder, skin, fascia, bone and spinal cord, in which the shear wavelength approaches the geometric dimensions of the object. The aim of this study was to develop and test mathematical inversion algorithms capable of resolving shear stiffness from displacement maps of flexural waves propagating in bounded media such as beams, plates, and spherical shells, using geometry-specific equations of motion. Magnetic resonance elastography and finite element modeling of beam, plate, and spherical shell phantoms of various geometries were performed. Mechanical testing of the phantoms agreed with the stiffness values obtained from finite element modeling and magnetic resonance elastography data, and a linear correlation of r(2) >or= 0.99 was observed between the stiffness values obtained using magnetic resonance elastography and finite element modeling data. In conclusion, we have demonstrated new inversion methods for calculating shear stiffness that may be more appropriate for waves propagating in bounded media.
Single‐scan MRI with exceptional resilience to field heterogeneities (2016)

xSPEN can deliver single-scan MRI with good sensitivity and exceptional resilience to field inhomogeneities. This could enable investigations that have hitherto escaped from MRI's scope. Magn Reson Med 77:623-634, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Achromatic volume holography using dispersive compensation for grating tilt (1989)

A method for achromatic volume holography is described using a combination of material and grating dispersion. With barium titanate as the dispersive material, a bandwidth of 250 nm is realized. The device may be used for broadband phase conjugation and image reconstruction.
Panache (2008)

Panache is a scalable, high-performance, remote file data caching solution integrated with the GPFS cluster file system. It leverages the inherent scalability of GPFS to provide a multi-node, consistent cache of data exported by a remote file system cluster. Panache exploits the soon-to-be standard pNFS protocol to move data in parallel from the remote file cluster. Furthermore, it provides a POSIX compliant file system interface making the cache completely transparent to applications. Panache can mask the fluctuating wide-area-network latencies and outages by supporting asynchronous and disconnected-mode operations. It allows concurrent updates to be made at the cache and at the remote cluster and synchronizes them by using conflict detection techniques to flag and handle conflicts. To maintain commercial viability, Panache relies on open standards for high-performance file serving and does not require any proprietary hardware or software to be deployed at the remote cluster. In this paper we present the overall architecture of Panache and its key features.
Immunotherapeutic Efficacy of IgY Antibodies Targeting the Full-Length Spike Protein in an Animal Model of Middle East Respiratory Syndrome Coronavirus Infection (2021)

Identified in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and often fatal acute respiratory illness in humans. No approved prophylactic or therapeutic interventions are currently available. In this study, we developed chicken egg yolk antibodies (IgY Abs) specific to the MERS-CoV spike (S) protein and evaluated their neutralizing efficiency against MERS-CoV infection. S-specific IgY Abs were produced by injecting chickens with the purified recombinant S protein of MERS-CoV at a high titer (4.4 mg/mL per egg yolk) at week 7 post immunization. Western blotting and immune-dot blot assays demonstrated specific binding to the MERS-CoV S protein. In vitro neutralization of the generated IgY Abs against MERS-CoV was evaluated and showed a 50% neutralizing concentration of 51.42 μg/mL. In vivo testing using a human-transgenic mouse model showed a reduction of viral antigen positive cells in treated mice, compared to the adjuvant-only controls. Moreover, the lung cells of the treated mice showed significantly reduced inflammation, compared to the controls. Our results show efficient neutralization of MERS-CoV infection both in vitro and in vivo using S-specific IgY Abs. Clinical trials are needed to evaluate the efficiency of the IgY Abs in camels and humans.
Fujitsu HIKARI, a Healthcare Decision Support System based on Biomedical Knowledge (2018)

Fujitsu HIKARI is an artificial intelligence solution to assist clinicians in medical decision making, developed in the context of a joint collaboration project between Fujitsu Laboratories of Europe and Hospital Clínico San Carlos. This decision support system leverages on data analytics combined with healthcare semantic information to provide health estimations for patients, improving care quality and personalized treatment. Fujitsu HIKARI stands on the shoulders of biomedical knowledge, which includes (i) theoretical knowledge extracted from scientific literature, domain expert knowledge, and health standards; and (ii) empirical knowledge extracted from real patient electronic health records. The theoretical knowledge combines a theoretical knowledge graph (TKG) and a biomedical document repository (BDR). The empirical knowledge is encoded in an empirical knowledge graph (EKG). One of the main functionalities of Fujitsu HIKARI is the patient mental health risks assessment, which is based on the exploitation of its underlying Biomedical Knowledge.