gebhart/patrepeval huggingface dataset:
24.3 20k-spin Ising chip for combinational optimization problem with CMOS annealing (2015)

In the near future, the performance growth of Neumann-architecture computers will slow down due to the end of semiconductor scaling. Presently a new computing paradigm, so-called natural computing, which maps problems to physical models and solves the problem by its own convergence property, is expected. The analog computer using superconductivity from D-Wave [1] is one of those computers. A neuron chip [2] is also one of them. We proposed a CMOS-type Ising computer [3]. The Ising computer maps problems to an Ising model, a model to express the behavior of magnetic spins (the upper left diagram in Fig. 24.3.1), and solves the problems by ground-state search operations. The energy of the system is expressed by the formula in the diagram. Computing flows are expressed in the lower flow chart in Fig. 24.3.1. In the conventional Neumann architecture, the problem is sequentially and repeatedly calculated, and therefore, the number of computing steps drastically increases as the problem size grows. In the Ising computer, in the first step, the problem is mapped to the Ising model. In the next steps, an annealing operation, the ground-state search by interactions between spins, are activated and the state transitions to the ground state where the energy of the system is minimized. The interacting operation between spins is decided by the interaction coefficients, which are set to each connection. Here, the configuration of the interaction coefficients is decided by the problem, and therefore, the interaction coefficients are equivalent to the programming in the conventional computing paradigm. The ground state corresponds to the solution of the original problem, and the solution is acquired by observing the ground state. The interactions for the annealing are performed in parallel, and the necessary steps for the annealing are smaller than that used by a sequential computing, Neumann architecture. As the table in Fig. 24.3.1, our Ising computer uses CMOS circuits to express the Ising model, and acquires the scalability and operation at room temperature.
Structural impact on SARS-CoV-2 spike protein by D614G substitution (2021)

Substitution for aspartic acid (D) by glycine (G) at position 614 in the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to facilitate rapid viral spread. The G614 strain and its recent variants are now the dominant circulating forms. Here, we report cryo-electron microscopy structures of a full-length G614 S trimer, which adopts three distinct prefusion conformations that differ primarily by the position of one receptor-binding domain. A loop disordered in the D614 S trimer wedges between domains within a protomer in the G614 spike. This added interaction appears to prevent premature dissociation of the G614 trimer-effectively increasing the number of functional spikes and enhancing infectivity-and to modulate structural rearrangements for membrane fusion. These findings extend our understanding of viral entry and suggest an improved immunogen for vaccine development.
Quantifying the cost and benefit of latency insensitive communication on FPGAs (2014)

Latency insensitive communication offers many potential benefits for FPGA designs, including easier timing closure by enabling automatic pipelining, and easier interfacing with embedded NoCs. However, it is important to understand the costs and trade-offs associated with any new design style. This paper presents optimized implementations of latency insensitive communication building blocks, quantifies their overheads in terms of area and frequency, and provides guidance to designers on how to generate high-speed and area-efficient latency insensitive systems.
Hypertrophic cardiomyopathy (2020)

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease. The disease is characterized by marked variability in morphological expression and natural history, ranging from asymptomatic to heart failure or sudden cardiac death. Left ventricular hypertrophy and abnormal ventricular configuration result in dynamic left ventricular outflow obstruction in most patients. The goal of pharmacological therapy in HCM is to alleviate the symptoms, and it includes pharmacotherapies and septal reduction therapies. In this review, we summarize the relevant clinical issues and treatment options of HCM.
In vivo magnetic resonance spectroscopy and dynamic contrast enhanced imaging of the prostate gland (1999)

The quantitation of in vivo 1H MR spectroscopy and dynamic contrast enhanced MR imaging is described for patients with histologically confirmed prostate adenocarcinoma and benign prostatic hypertrophy (BPH). Results are presented which suggest that combined use of these techniques may be helpful in improving the characterization of prostate pathologies and ultimately increase the staging accuracy of magnetic resonance.
Towards tamper-evident storage on patterned media (2008)

We propose a tamper-evident storage system based on probe storage with a patterned magnetic medium. This medium supports normal read/write operations by out-of-plane magnetisation of individual magnetic dots. We report on measurements showing that in principle the medium also supports a separate class of write-once operation that destroys the out-of-plane magnetisation property of the dots irreversibly by precise local heating. We discuss the main issues of designing a tamper-evident storage device and file system using the properties of the medium.
The SRS railgun: a new approach to restrike control (1989)

A segmented rail surface (SRS) structure is described that eliminates restrike arcs by progressively disconnecting segments of the rail surface after the plasma armature has passed. This technique has been demonstrated using the Los Alamos MIDI-2 railgun. Restrike was eliminated in a plasma armature acceleration experiment using metal-foil fuses as opening switches. A plasma velocity increase from 11 to 16 km/s was demonstrated using the SRS technique to eliminate the viscous drag losses associated with the restrike plasma. It is concluded that this technique is a practical option for a laboratory launcher at present and for future multishot launchers if appropriate switches can be developed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Microstructure and High-temperature Tribological Properties of TANC/CFBF Self-lubricating Materials (2008)

Ti-48Al-2Nb-2Cr self-lubricating materials with addition of different weight contents of 38%CaF2-62%BaF2 eutectic solid lubricant(TANC/CFBF)(5,10,15,20%,respectively) were fabricated by vacuum hot pressing technology. The wear mechanism and film forming theory were discussed.
The Thing (2021)

<JATS1:p>An extra-terrestrial alien, capable of replicating any living form it touches, infiltrates an isolated research base in the Antarctic, and sows suspicion and terror among the men trapped there. Which of them is still human, and which a perfect alien facsimile? John Carpenter’s The Thing, the second adaptation of John W. Campbell’s 1938 novella Who Goes There?, received overwhelmingly negative reviews on its release in 1982, but has since been acknowledged as a classic fusion of the science fiction and horror genres. Now a regular fixture in lists of the greatest movies of all time, it is acclaimed for its inspired and still shocking practical special effects, its deftly sketched characters brought to life by a superb cast, elegant widescreen cinematography, ominous score, and a uniquely tense narrative packed with appropriately ever-changing metaphors about the human condition.</JATS1:p> <JATS1:p>Anne Billson’s elegant and trenchant study, first published in 1997, was one of the first publications to give the film its due as a modern classic, hailing it as a landmark movie that brilliantly redefined horror and science fiction conventions, and combined them with sly humour, Lewis Carroll logic and disturbingly prescient metaphors for many of the sociopolitical, scientific and medical upheavals of the past three decades.</JATS1:p> <JATS1:p>In her foreword to this new edition, Anne Billson reflects upon The Thing's changing fortunes in the years since its release, its influence on film-makers including Tarantino and del Toro, and its topicality in an era of melting ice caps and with humanity besieged by a deadly organism.</JATS1:p>
AN IMPROVED METHOD TO PREPARE CATALYSTS FOR THE SELECTIVE DECARBONYLATION OF FURAN-2 CARBOXALDEHYDE INTO FURAN (1983)

Abstract We are able to produce pure furan and pure carbon monoxide from furan-2 carboxaldehyde using an improved catalyst. This new catalyst (Pd/C–K2CO3) is activated by UV irradiation at 254 nm for 1 h.
Magrolimab in combination with azacitidine for untreated higher-risk myelodysplastic syndromes (HR-MDS): 5F9005 phase 1b study results. (2022)

7017 Background: Magrolimab is a monoclonal antibody that blocks CD47, a “don’t eat me” signal overexpressed on cancer cells. CD47 blockade by magrolimab induces macrophage-mediated phagocytosis of tumor cells and is synergistic with azacitidine (AZA) via upregulation of “eat me” signals. Here we report final Phase 1b data in patients (pts) with untreated HR-MDS (NCT03248479). Methods: Pts with previously untreated intermediate-/high-/very high-risk MDS per IPSS-R received magrolimab IV as a priming dose (1 mg/kg) followed by ramp-up to a 30 mg/kg weekly or Q2W maintenance dose. AZA 75 mg/m 2 was administered IV or SC on Days 1–7 of each 28-day cycle. Primary endpoints were safety/tolerability and complete remission (CR) rate. Results: 95 pts (median age 69 years [range 28, 91]) were treated. IPSS-R risk was intermediate, high, or very high in 27%, 52%, and 21%, respectively. MDS was therapy-related in 22%; 26% (n=25) had a TP53 mutation and 62% had poor-risk cytogenetics (27% complex). Median (range) number of cycles was 6 (1, 27). The most common TEAEs included constipation (68%), thrombocytopenia (55%), anemia (52%), neutropenia (47%), nausea (46%), and diarrhea (44%). The most common Grade 3/4 TEAEs included anemia (47%), neutropenia (46%), thrombocytopenia (46%), and WBC count decreased (30%). 6 pts discontinued treatment due to AEs. 60-day mortality was 2%. Median Hb change from baseline (BL) at first post-dose sample was –0.7 g/dL (range –3.1, +2.4). CR and objective response (OR) rates were 33% and 75% with 31% of evaluable OR pts with abnormal cytogenetics at BL having cytogenetic CR. Median time to first OR, duration of CR (DCR), duration of OR, and PFS were 1.9, 11.1, 9.8, and 11.6 mos. OS rates at 12 and 24 mos were 75% and 52%, respectively (median NR with 17.1 mos follow-up for OS). For patients evaluated with sequential WES with a VAF cutoff of 5%, 3 of 3 pts with TP53 mutation who achieved CR had TP53 VAF <5% by C5D1. Favorable outcomes were observed in both TP53 mutant (40% CR, median OS 16.3 months) and wildtype pts (31% CR, median OS NR; Table). Conclusions: Magrolimab+AZA was well tolerated with promising efficacy in pts with untreated HR-MDS including those with TP53-mut and TP53-wt disease. A Phase 3 trial of magrolimab/placebo+AZA (ENHANCE: NCT04313881) is ongoing. Clinical trial information: NCT03248479. [Table: see text]
Pulsed Laser Deposition of Bioceramic Hydroxyapatite Thin Films on Polymer Materials (1996)

The ArF excimer laser deposition technique has been used to fabricate bioceramic hydroxyapatite (HAp) thin films on polymer materials such as polyimides (PI), polytetrafluoroethylene (PTFE), silicone rubber (SR), and polyethyleneterephthalate (PET). The crystallinity, structure, composition and surface morphology of HAp films are evaluated by X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX) and atomic force microscopy (AFM). Crystallized HAp films are obtained on PI and PTFE, and mechanical properties of HAp films on the polymer materials are examined using an Instron testing machine. This result is very important to enable the application of organic/inorganic-ceramic composite materials in medical fields.
Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells (2008)

Bufalin is a traditional Chinese medicine and it induces apoptosis in certain human tumor cell lines. We investigated the effect of bufalin on three endometrial cancer cell lines, two ovarian cancer cell lines, and on normal human endometrial epithelial cells. Endometrial and ovarian cancer cells were treated with various concentrations of bufalin, and its effect on cell growth, cell cycle, apoptosis, and related measurements was investigated. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that all endometrial and ovarian cancer cell lines were sensitive to the growth-inhibitory effect of bufalin, although normal endometrial epithelial cells were viable after treatment with the same doses of bufalin that induced growth inhibition in endometrial and ovarian cancer cells. Cell cycle analysis indicated that their exposure to bufalin decreased the proportion of cells in the S-phase and increased the proportion in the G0/G1 phases of the cell cycle. Induction of apoptosis was confirmed by annexin V staining of externalized phosphatidylserine and loss of the transmembrane potential of mitochondria. This induction occurred in concert with the altered expression of genes related to cell cycle and apoptosis. These results suggest that bufalin may become a useful adjuvant therapy for endometrial and ovarian cancers with minimal side effects.
Sudoku Variants on the Torus (2017)

This paper examines the mathematical properties of Sudoku puzzles defined on a Torus. We seek to answer the questions for these variants that have been explored for the traditional Sudoku. We do this process with two such embeddings. The end result of this paper is a deeper mathematical understanding of logic puzzles of this type, as well as a fun new puzzle which could be played.
New Isoprenylated Flavones, Artochamins A−E, and Cytotoxic Principles from <i>Artocarpus </i><i>c</i><i>hama</i> (2004)

Five new isoprenylated flavones, artochamins A-E (1-5), together with eight known flavones (6-13), were isolated from the roots of Artocarpus chama. All structures were elucidated by spectroscopic methods. Artonin E (12) showed strong cytotoxicity against 1A9 (ovarian), significant activity against MCF-7 (breast adenocarcinoma), and moderate activity against HCT-8 (ileocecal) and MDA-MB-231 (breast adenocarcinoma) tumor cell lines. Artochamin C (3) was more potent against MCF-7, 1A9, HCT-8, and SK-MEL-2 (melanoma) than A549 (lung carcinoma), KB (epidermoid carcinoma of the nasopharynx), and its drug-resistant (KB-VIN) variant. Artocarpin (6) displayed weak but relatively broad inhibitory effects compared with 3 and 12.
Electrical characterization of radiofrequency glow discharge used for optical emission spectroscopy (2003)

Abstract This paper considers the electrical characterization of radiofrequency glow discharge plasmas used for optical emission spectroscopy. The total discharge current and the applied voltage are measured using conventional techniques. With a simple analytical approach and using adequate assumptions that will be detailed in the paper, we show that it is possible to estimate the different components of the total discharge current and to characterize electrically the sheath and the plasma region of the discharge. This allows information to be obtained on the electric field on the sample, the sheath length, the ion density in the sheath and the plasma density. Copyright © 2003 John Wiley & Sons, Ltd.
Protective Effect of a Pancreatic Elastase Inhibitor Against a Variety of Acute Pancreatitis in Rats (1998)

Protective effect of trifluoroacetyl-L-lysyl-L-alaninanilide hydrochloride (compound 1), a pancreatic elastase inhibitor, on three types of acute pancreatitis models was examined in rats. Mild, moderate and severe acute pancreatitis were induced by cerulein, the closed duodenal loop method and retrograde injection of a taurocholate plus trypsin solution into the pancreatic duct, respectively. Intravenous infusion of compound 1 at a dose of 30 mg/kg/hr resulted in lower increases in serum amylase, lipase, blood urea nitrogen (BUN) and creatinine levels in rats with mild cerulein-induced edematous pancreatitis. Compound 1 had no beneficial effect on pancreatitis in rats with moderate pancreatitis. In rats with severe pancreatitis, prophylactic treatment of compound 1 (30 mg/kg/hr) reduced both elevated serum BUN level and ascitic volume, and it histologically inhibited the extent of pancreatic edema and hemorrhage. These results suggest that pancreatic elastase is partially responsible for pancreatic edema and hemorrhage exhibited by rats with severe acute pancreatitis.
Spectral Combining For Microphone Diversity Systems (2009)

Publication in the conference proceedings of EUSIPCO, Glasgow, Scotland, 2009
Assessment of Correlation between Transcerebellar Diameter and Gestation Age in IUGR Pregnancies (2022)

Background: Accurate assessment of the gestational age is very critical in the management of IUGR cases and their associated complications. Present study was done with the objective to evaluate the Correlation between Transcerebellar Diameter and Gestation age in IUGR pregnancies. Materials and Methods: This Prospective Cross-sectional study was conducted on antenatal women of gestational age 15-40 weeks with IUGR pregnancies cases attending the antenatal clinic and admitted in the Department of Obstetrics and gynecology, and sent to Department of Radiology KNSH M&C and IGMC Shimla for Antenatal USG Scan. In every patient TCD was measured. Data was analysed by appropriate statistical test using EPI INFO Version 7.2 software. Correlation coefficients were then used to compare TCD with Gestational age in IUGR pregnancies. Results: In this study 120 cases were studied out of which 20 were pregnancies with IUGR. Age distribution of IUGR pregnancies was 20 to 27 years with mean age of 22.6±2.14 years. Maximum number of patients 13(65%) was between 21-25 years followed by 16-20 years 4(20%). Youngest patient was 20 years old and the eldest was 27 years. Maximum number of patients 8(40%) was between 30-36 weeks and 36-42 weeks of gestation and least number of patients 1 (5%) were between 24-30 weeks. In third trimester of pregnancy it was observed that TCD shows strongest correlation with gestational age and shows a statistically significant correlation (p<0.001). It was noted that there is a correlation between gestational age and TCD in second trimester of IUGR pregnancies however the correlation was statistically insignificant (p>0.05). Conclusion: TCD is better predictor of gestational age in IUGR pregnancies as it remains nearly unaffected and correlates more closely with gestational age both in second and third trimester of pregnancy.
Weight Reduction and the Impaired Plasma-Derived Free Fatty Acid Oxidation in Type 2 Diabetic Subjects (2001)

J Clin Endocrinol Metab 2001 Apr;86(4):1638-44 Related Articles, Books, LinkOut <br/><br/> <br/>Weight reduction and the impaired plasma-derived free fatty acid oxidation in type 2 diabetic subjects.<br/><br/>Blaak EE, Wolffenbuttel BH, Saris WH, Pelsers MM, Wagenmakers AJ.<br/><br/>Department of Human Biology, Nutrition Research Center, Maastricht University, 6200 MD Maastricht, The Netherlands. e.blaak@hb.unimaas.nl<br/><br/>In a previous study the oxidation of plasma free fatty acids (FFA) under baseline conditions and during exercise was lower in type 2 diabetic subjects compared with weight-matched controls. The present study intended to investigate the effect of weight reduction (very low calorie diet) on plasma FFA oxidation in seven type 2 diabetic male subjects (body fat, 37.4 +/- 1.2%; age, 51.3 +/- 3.4 yr; plasma glucose, 7.45 +/- 0.48 mmol/L). Subjects underwent a 10-week diet period. Body composition and substrate utilization during rest and during bicycle exercise (50% of maximum aerobic capacity) were determined before and after the diet (during weight-stable conditions). FFA metabolism was studied by means of the tracer [U-(13)C]palmitate. Rates of oxidation of plasma FFA were corrected with an acetate recovery factor. Additionally, activities of mitochondrial enzymes and cytosolic fatty acid-binding protein were determined in biopsies from the vastus lateralis muscle before and after the diet. The very low calorie diet resulted in a weight loss of 15.3 kg (110.8 +/- 7.4 vs. 95.5 +/- 5.8 kg; P < 0.01). The basal rates of appearance and disappearance of FFA decreased as a result of diet. The rates of appearance and disappearance of FFA during exercise were not different before and after diet. The oxidation of plasma-derived fatty acids tended to decrease after diet during baseline conditions (P = 0.10), whereas the plasma FFA oxidation during exercise was not different before and after the diet (14.1 +/- 1.9 vs. 14.8 +/- 1.8 micromol/kg fat-free mass.min). Skeletal muscle cytosolic fatty acid-binding protein and the activities of muscle oxidative enzymes did not significantly change as a result of weight loss. In conclusion, considerable weight reduction did not significantly improve plasma-derived FFA oxidation under baseline conditions and during exercise, suggesting that this impairment reflects a primary defect leading to the development of type 2 diabetes mellitus rather than resulting from the type 2 diabetic state.<br/><br/>
A New Model to Compute the Information Content of Concepts from Taxonomic Knowledge (2012)

The Information Content (IC) of a concept quantifies the amount of information it provides when appearing in a context. In the past, IC used to be computed as a function of concept appearance probabilities in corpora, but corpora-dependency and data sparseness hampered results. Recently, some other authors tried to overcome previous approaches, estimating IC from the knowledge modeled in an ontology. In this paper, the authors develop this idea, by proposing a new model to compute the IC of a concept exploiting the taxonomic knowledge modeled in an ontology. In comparison with related works, their proposal aims to better capture semantic evidences found in the ontology. To test the authors’ approach, they have applied it to well-known semantic similarity measures, which were evaluated using standard benchmarks. Results show that the use of the authors’ model produces, in most cases, more accurate similarity estimations than related works.
Infrared chemical imaging with scanning quantum cascade laser microscopy systems (2021)

Infrared spectroscopic imaging is an analytical approach that can reveal important molecular information without the need for substantial sample processing. These instruments can provide objective and automated evaluations to aid pathologists improve diagnostic accuracy. The quantum cascade laser, allows for a discrete frequency approach, increasing imaging speeds with superior spatial and spectral resolution. We present our recent progress toward developing new instruments capable of diffraction limited performance at all fingerprint-region wavelengths across the entire field of view. We demonstrate high throughput imaging of tissue sections and tissue microarrays and evaluate the advantages in data quality obtained from a well-corrected system.
Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System (2020)

We have designed and dosimetrically validated a FLASH-PRT system with accurate control of beam flux on a millisecond time scale and online monitoring of the integral and dose delivery time structure. Using this system, we found that FLASH-PRT decreases acute cell loss and late fibrosis after whole-abdomen and focal intestinal RT, whereas tumor growth inhibition is preserved between the 2 modalities.