gebhart/patrepeval huggingface dataset:
Extended Gaussian Filtering for Noise Reduction in Spectral Analysis (2020)

We present a method of reducing noise in spectra that is based on eliminating low-order derivatives of reciprocal-space (RS) filter functions, yet ensuring that the functions roll off smoothly to minimize Gibbs oscillations. The approach takes advantage of the fact that information and noise are separated in RS. The method preserves as much information as possible, while reducing or even eliminating unwanted contributions (noise). To demonstrate the method we apply it to a model spectrum, data including an XPS spectrum of S2p in hierarchical NiCo2S4 nanosheets, and the Raman spectrum of 10-layer film of FePS3 with polarization direction of 90° with respect to the a-axis.
Bis(triphenylphosphine) iminium nitrite, mild, versatile nitrosylating reagent (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBis(triphenylphosphine) iminium nitrite, mild, versatile nitrosylating reagentRobert E. Stevens, Timothy J. Yanta, and Wayne L. GladfelterCite this: J. Am. Chem. Soc. 1981, 103, 16, 4981–4982Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/ja00406a069https://doi.org/10.1021/ja00406a069research-articleACS PublicationsRequest reuse permissionsArticle Views290Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mechanistic Studies and <i>In Vivo</i> Efficacy of an Oxadiazole-Containing Antibiotic (2022)

Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infections are still difficult to treat, despite the availability of many FDA-approved antibiotics. Thus, new compound scaffolds are still needed to treat MRSA. The oxadiazole-containing compound, <b>HSGN-94</b>, has been shown to reduce lipoteichoic acid (LTA) in <i>S. aureus</i>, but the mechanism that accounts for LTA biosynthesis inhibition remains uncharacterized. Herein, we report the elucidation of the mechanism by which <b>HSGN-94</b> inhibits LTA biosynthesis via utilization of global proteomics, activity-based protein profiling, and lipid analysis via multiple reaction monitoring (MRM). Our data suggest that <b>HSGN-94</b> inhibits LTA biosynthesis via direct binding to PgcA and downregulation of PgsA. We further show that <b>HSGN-94</b> reduces the MRSA load in skin infection (mouse) and decreases pro-inflammatory cytokines in MRSA-infected wounds. Collectively, <b>HSGN-94</b> merits further consideration as a potential drug for staphylococcal infections.
Prediction of Coal Ash Thermal Properties Using Partial Least-Squares Regression (2003)

The partial least-squares regression (PLSR) method is used to develop empirical correlations for predicting coal ash fusion temperatures (AFTs) under reducing conditions and the temperature of critical viscosity (Tcv) from the chemical composition. The database used in this work includes 433 ash samples from coals of different sources. PLSR is a powerful tool that is able to identify the most significant variables affecting coal ash thermal properties, suggesting ways of modifying the slag melting behavior. The final correlations show good predictive results with predictive standard deviations of less than 90 °C; they represent a simple and reliable tool for predicting the thermal behavior of coal ash and the effects of additives and blending of different coals.
Static magnetic field exposure fails to affect the viability of different bacteria strains (2009)

The viability of the microbes Saccharomyces cerevisiae, Bacillus circulans, Escherichia coli, Micrococcus luteus, Pseudomonas fluorescens, Salmonella enteritidis, Serratia marcescens, and Staphylococcus aureus was tested under static magnetic field exposure up to 24 h in either a homogeneous (159.2 +/- 13.4 mT) or three types of inhomogeneous static magnetic fields: (i) peak-to-peak magnetic flux density 476.7 +/- 0.1 mT with a lateral magnetic flux density gradient of 47.7 T/m, (ii) 12.0 +/- 0.1 mT with 1.2 T/m, or (iii) 2.8 +/- 0.1 mT with 0.3 T/m. Even the longest period of exposure failed to produce any effect in the growth of bacteriae that could be correlated with static magnetic field exposure.
Human Resource Accounting (1994)

Abstract Looks at the general issue of prescriptive and descriptive approaches to management research, and the tensions that exist between these two approaches. Considers these issues with particular reference to human resource accounting.
DPP6 localization in brain supports function as a Kv4 channel associated protein (2008)

The gene encoding the dipeptidyl peptidase-like protein DPP6 (also known as DPPX) has been associated with human neural disease. However, until recently no function had been found for this protein. It has been proposed that DPP6 is an auxiliary subunit of neuronal Kv4 K(+) channels, the ion channels responsible for the somato-dendritic A-type K(+) current, an ionic current with crucial roles in the regulation of firing frequency, dendritic integration and synaptic plasticity. This view has been supported mainly by studies showing that DPP6 is necessary to generate channels with biophysical properties resembling the native channels in some neurons. However, independent evidence that DPP6 is a component of neuronal Kv4 channels in the brain, and whether this protein has other functions in the CNS is still lacking. We generated antibodies to DPP6 proteins to compare their distribution in brain with that of the Kv4 pore-forming subunits. DPP6 proteins were prominently expressed in neuronal populations expressing Kv4.2 proteins and both types of protein were enriched in the dendrites of these cells, strongly supporting the hypothesis that DPP6 is an associated protein of Kv4 channels in brain neurons. The observed similarity in the cellular and subcellular patterns of expression of both proteins suggests that this is the main function of DPP6 in brain. However, we also found that DPP6 antibodies intensely labeled the hippocampal mossy fiber axons, which lack Kv4 proteins, suggesting that DPP6 proteins may have additional, Kv4-unrelated functions.
Reliable Human Detection and Tracking in Top-View Depth Images (2013)

The paper presents a method for human detection and tracking in depth images captured by a top-view camera system. We introduce a new feature descriptor which outperforms state-of-the-art features like Simplified Local Ternary Patterns in the given scenario. We use this feature descriptor to train a head-shoulder detector using a discriminative class scheme. A separate processing step ensures that only a minimal but sufficient number of head-shoulder candidates is evaluated. This contributes to an excellent runtime performance. A final tracking step reliably propagates detections in time and provides stable tracking results. The quality of the presented method allows us to recognize many challenging situations with humans tailgating and piggybacking.
Composite smart skin systems (1990)

A smart skin system for inclusion into composite structures is presented. The composite structure can be considered for both underwater and air-borne applications. Individual component designs in the skin include a piezoelectric SAW sensor for the characterization of both the local and global boundary flow layer, piezocomposite sensors and actuators for noise and vibration control, and an array of piezocomposite shear transducers for local damage assessment. Recent research results of the components will be presented. Conceptual system designs will be discussed.
Development of a Novel In Vitro Human Tissue-Based Angiogenesis Assay to Evaluate the Effect of Antiangiogenic Drugs (2003)

Epothilone B may be an effective antiangiogenic agent in a variety of tumor types. The authors speculate that this in vitro model might provide useful information to the clinician on the effect of specific antiangiogenic agents on individual tumors. This may be particularly useful in patients with tumors that, as a group, are unresponsive to treatment with antineoplastic agents.
3D Point Cloud Compression (2019)

In recent years, 3D point clouds have enjoyed a great popularity for representing both static and dynamic 3D objects. When compared to 3D meshes, they offer the advantage of providing a simpler, denser and more close-to-reality representation. However, point clouds always carry a huge amount of data. For a typical example of a point cloud with 0.7 million points per 3D frame at 30 fps, the point cloud raw video needs a bandwidth around 500MB/s. Thus, efficient compression methods are mandatory for ensuring the storage/transmission of such data, which include both geometry and attribute information. In the last years, the issue of 3D point cloud compression (3D-PCC) has emerged as a new field of research. In addition, an ISO/MPEG standardization process on 3D-PCC is currently on-going. In this paper, a comprehensive overview of the 3D-PCC state-of-the-art methods is proposed. Different families of approaches are identified, described in details and summarized, including 1D traversal compression, 2D-oriented techniques, which take leverage of existing 2D image/video compression technologies and finally purely 3D approaches, based on a direct analysis of the 3D data.
Framework for computer based safety-related systems: overview of draft international standard IEC 1508 (2002)

This article provides an overview of the proposed International Electrotechnical Commission (IEC) standard (IEC 1508) entitled "Functional safety of electrical/electronic/programmable electronic safety-related systems" which sets out a generic approach for all Safety Lifecycle activities for electrical/electronic/programmable electronic systems (E/E/PESs) that are used to perform safety functions. The emergence of this international standard should be a major step towards the adoption of a more rational and consistent technical policy for all electrically based safety-related systems. A major objective is to facilitate the development of application sector standards. The article also considers priorities for the future if both the safety and economic benefits are to be fully realised from the adoption of this proposed international standard.
<b>Volatile constituents of <i>Glechoma hirsute</i> Waldst. & Kit. and <i>G. hederacea</i> L. (<i>Lamiaceae</i>)</b> (2010)

The essential oils of two Glechoma species from Serbia have been analyzed by GC and GC/MS. Eighty eight and two hundred thirty eight constituents identified accounted for 90.6 and 86.6% of the total oils of G. hirsuta Waldst. & Kit. and G. hederacea L., respectively. In both oils the dominant constituent class was the terpenoid one, 75.7% in G. hirsuta and 47.4% in G. hederacea. 1,8-Cineole (42.6%) and spathulenol (7.4%) were the main constituents of G. hirsuta oil while palmitic (13.3%) and linoleic acids (9.3%) alongside with germacrene D (7.3%) were the major ones of G. hederacea oil. The relative percentage of the sesquiterpene fraction (19.5%) and fatty acid derived compounds (7.6%) distinguished nicely G. hirsuta from G. hederacea. Additionally, oxygenated sesquiterpenes (16.9%) dominated the oil of G. hirsuta, while the reversed situation was noted for G. hederacea oil (the hydrocarbon sesquiterpenes amounted to only 2.6%). The results obtained provide a rationale for the parallel ethnopharmacological usage of G. hirsuta and G. hederacea. This is the first report on the composition of G. hirsuta oil. KEY WORDS: Glechoma hirsuta Waldst. & Kit., Glechoma hederacea L., Lamiaceae, Essential oil composition, 1,8-Cineole, Spathulenol, Germacrene D, Linoleic acid, Palmitic acid, Ethnopharmacological use Bull. Chem. Soc. Ethiop. 2010, 24(1), 67-76.
Shaping High-Power IGBT Switching Transitions by Active Voltage Control for Reduced EMI Generation (2014)

High-performance power switching devices [insulated-gate bipolar transistors (IGBTs)] realize high-performance power converters. Unfortunately, with a high switching speed of the IGBT-freewheel diode chopper cell, the circuit becomes intrinsic sources of high-level electromagnetic interference (EMI). Therefore, costly EMI filters or shielding is normally demanded on the load and supply sides. An S-shaped voltage transient with a high-order time derivative eliminates the discontinuity in the switching transient and can suppress high-frequency spectrum of EMI emissions. More importantly, it provides an improved tradeoff between EMI generation and switching time, therefore switching losses. This promising tradeoff can be explored further for better high-frequency EMI suppression by using the infinitely differentiable characteristics of Gaussian S-shaped transients. However, current gate drive schemes cannot achieve the S shaping. In this paper, active voltage control is applied and improved successfully to define IGBT switching dynamics with a smoothed Gaussian waveform.
Cités, campagnes et centres locaux en Gaule narbonnaise aux premiers siècles du Moyen Age (ve-ixe s.) : une nouvelle géographie, de nouveaux liens (2007)

Depuis une vingtaine d’années, le développement de l’archéologie de terrain et l’accession de la prospection au sol au rang de méthode archéologique ont contribué à décloisonner un champ de la recherche qui demeurait en grande partie hermétique. Le haut Moyen Age languedocien sort peu à peu de l’ombre dans laquelle il était plongé. Pour autant, les progrès accomplis dans le renouvellement des données sont bien loin encore d’avoir levé toutes nos incertitudes. Les nouvelles enquêtes archéologi...
A parameter choice strategy for (iterated) tikhonov regularization of iii-posed problems leading to superconvergence with optimal rates (1988)

For ordinary and iterated Tikhonov regularization of linear ill-posed problems, we propose a parameter choice strategy that leads to optimal (super-) convergence rates for certain linear functionals of the regularized solution. It is not necessary to know the smoothness index of the exact solution; approximate knowledge of the smoothness index for the linear functional suffices
Analysis of spectral interpolation with weighting dependent on frame energy (2002)

Spectral interpolation improves the performance of low bit rate speech coders without increasing the bit rate. We have investigated the problem of spectral interpolation, by means of autoregressive theory. Our analysis is supported by experiments on stationary and non-stationary data and by experiments on real speech data. The main conclusions of our study are: the energy of the analysis frames should be used in the interpolation process. It is beneficial to give analysis frames an overlap of p samples, where p is the order of the model. The reflection coefficients, log area ratios and the arcsine of reflection coefficients are less suitable for interpolation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Toll like receptor 2 mediates bleomycin-induced acute lung injury, inflammation and fibrosis in mice. (2010)

Anti-cancer drug bleomycin (BLM) can cause acute lung injury (ALI) which often results in pulmonary fibrosis due to a failure of resolving acute inflammatory response. The aim of this study is to investigate whether toll-like receptor (TLR) 2 mediates BLM-induced ALI, inflammation and fibrosis. BLM-induced dendritic cells (DCs) maturation was analyzed by flow cytometry and cytokine secretion was detected by the ELISA method. The expression and activity of p38 and ERK MAPK were determined with Western blotting. The roles of TLR2 in ALI, inflammation and fibrosis were investigated in C57BL/6 mice administered intratracheally with BLM. The results demonstrated that BLM-administered mice had higher expression of TLR2 (P<0.001) and its signaling molecules. Blocking TLR2 significantly inhibited the maturation of DCs and reversed BLM-stimulated secretion of cytokines in DCs, such as IL-6 (P<0.001), IL-17 (P<0.05) and IL-23 (P<0.05). TLR2 inhibition attenuated BLM-induced increase of inflammatory cells in bronchoalveolar lavage fluid (BALF), and reversed the immunosuppressive microenvironment by enhancing TH1 response (P<0.05) and inhibiting TH2 (P<0.001), Treg (P<0.01) and TH17 (P<0.01) responses. Importantly, blocking TLR2 in vivo significantly protected BLM-administered mice from pulmonary injury, inflammation and fibrosis and subsequently increased BLM-induced animal survival (from 50% to 92%). Therefore, TLR2 is a novel potential target for ALI and pulmonary fibrosis.
Transition Metal Complexes Based on Hypergolic Anions for Catalysis of Ammonium Perchlorate Thermal Decomposition (2020)

On the basis of hypergolic dicyandiamide (DCA) and cyanoborohydride (CBH) anions, 1-methyl-1,2,4-triazole (MTZ) ligand, and transition metal (Co/Ni/Cu) cations, five hypergolic coordination compounds (HCCs) were synthesized and characterized. Their molecular formulas were expressed as [Co(MTZ)4](DCA)2 (1), [Ni(MTZ)4](DCA)2 (2), [Cu(MTZ)2](DCA)2 (3), [Co(MTZ)4](CBH)2 (4), and [Ni(MTZ)4](CBH)2 (5). Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) instruments were used to investigate the thermal decomposition behaviors of compounds 1–5, and the DSC instrument was used to investigate the catalytic effect of HCCs on the thermal decomposition of ammonium perchlorate (AP). High-temperature decomposition (HTD) of AP samples with 5% catalyst occurred immediately after low-temperature decomposition (LTD), and their HTD temperatures were lowered by 60–116 °C. The heat release of all samples is improved observably and is 2–3 times that of pure AP. Among them, compound 1 shows the best catalytic performance. The heat release of sample AP + compound 1 can reach 2291 J g–1, and the decomposition temperature can be advanced by 116 °C. The kinetic/thermodynamic parameters were calculated to further study the catalytic mechanism of HCCs on the thermal decomposition of AP. The research in this paper shows that HCCs were suggesting for a class of novel additives of composite propellants with improved combustion and energetic performances.
TOSCA Solves Big Problems in the Cloud and Beyond! (2018)

TOSCA, the “Topology and Orchestration Specification for Cloud Applications” offers an OASISrecognized, open standard domain-specific language (DSL) that enables portability and automated management of applications, services, and resources regardless of underlying cloud platform, software defined environment, or infrastructure. With a growing, interoperable ecosystem of open source projects, solutions from leading cloud platform and service providers, and research, TOSCA empowers the definition and modeling of applications and their services (microservices or traditional services) across their entire lifecycle by describing their components, relationships, dependencies, requirements, and capabilities for orchestrating software in the context of associated operational policies. The authors introduce important TOSCA concepts and benefits in the context of commonly understood cloud use cases as a foundation to future discussions regarding advanced TOSCA concepts and additional breakthrough issues.
Interferon-Gamma Producing Regulatory T Cells as a Diagnostic and Therapeutic Tool in Organ Transplantation (2013)

There is increasing evidence that IFNg plays a major role in both induction of Tregs as well as immunosuppression mediated by IFNg-producing Tregs. The present review focuses on a small subset of iTregs that produces IFNg, comprises only 0.04% of all CD4(+) T lymphocytes in the blood of healthy individuals, and increases strongly during an immune response. IFNg(+) Tregs are induced by IFNg and IL12, making them sensors for inflammatory cytokines. They develop rapidly during inflammation and represent the first line of Tregs that suppress initial immune responses. The pool of IFNg(+) Tregs consists of activated stable immunosuppressive thymus-derived nTregs as well as peripherally proliferating iTregs with in part only transient immunosuppressive function, which limits their diagnostic and therapeutic usefulness in organ transplantation. Apparently, a part of IFNg(+) Tregs dies during the immune response, whereas others, after efficient immunosuppression with resolution of the immune response, differentiate toward Th1 lymphocytes. Goals of further research are the development of appropriate diagnostic tests for rapid and exact determinination of immunosuppressive IFNg(+) iTregs, as well as the induction and propagation of stable immunosuppressive IFNg(+) Tregs that establish and maintain good long-term graft function in transplant recipients.
CD73 Blockade Promotes Dendritic Cell Infiltration of Irradiated Tumors and Tumor Rejection (2020)

The ability of focal radiotherapy to promote priming of tumor-specific CD8<sup>+</sup> T cells and increase responses to immunotherapy is dependent on infiltration of the tumor by Batf3-dependent conventional dendritic cell type 1 (cDC1) cells. Such infiltration is driven by radiotherapy-induced IFN type I (IFN-I). Other signals may also modulate cDC1 infiltration of irradiated tumors. Here we found increased expression of adenosine-generating enzymes CD38 and CD73 in irradiated mouse and human breast cancer cells and increased adenosine in mouse tumors following radiotherapy. CD73 blockade alone had no effect. CD73 blockade with radiotherapy restored radiotherapy-induced cDC1 infiltration of tumors in settings where radiotherapy induction of IFN-I was suboptimal. In the absence of radiotherapy-induced IFN-I, blockade of CD73 was required for rejection of the irradiated tumor and for systemic tumor control (abscopal effect) in the context of cytotoxic T-lymphocyte-associated protein 4 blockade. These results suggest that CD73 may be a radiation-induced checkpoint, and that CD73 blockade in combination with radiotherapy and immune checkpoint blockade might improve patient response to therapy.
Solution Behavior of a Novel Biopharmaceutical Drug Candidate: A Gonadotropin-Toxin Conjugate (2006)

There is little known about the solution structure and stability of peptide-protein conjugates, which comprise a new class of potential biopharmaceutical agents. This study describes the solution behavior of gonadotropins-releasing hormone (GnRH) chemically conjugated to pokeweed antiviral protein (PAP). The conjugate adopts a well-defined conformation across a pH range of 4 to 8. Even after heating to 80 degrees C, the conjugate retains a significant amount of secondary and tertiary structure. Heating for 1 h at 60 degrees C does lead to chemical damage, as determined by cation exchange chromatography. Using an experimental design approach, the optimal pH and salt concentration for limiting chemical damage was determined.