gebhart/patrepeval huggingface dataset:
Evaluating disaster recovery plans using the cloud (2013)

Every organization requires a business continuity plan (BCP) or disaster recovery plan (DRP) which falls within cost constraints while achieving the target recovery requirements in terms of recovery time objective (RTO) and recovery point objective (RPO). The organizations must identify the likely events that can cause disasters and evaluate their impact. They need to set the objectives clearly, evaluate feasible disaster recovery plans to choose the DRP that would be optimal. The paper examines tradeoffs involved and presents guidelines for choosing among the disaster recovery options. The optimal disaster recovery planning should take into consideration the key parameters including the initial cost, the cost of data transfers, and the cost of data storage. The organization data needs and its disaster recovery objectives need to be considered. To evaluate the risk, the types of disaster (natural or human-caused) need to be identified. The probability of a disaster occurrence needs to be assessed along with the costs of corresponding failures. An appropriate approach for the cost evaluation needs to be determined to allow a quantitative assessment of currently active disaster recovery plans (DRP) in terms of the time need to restore the service (associated with RTO) and possible loss of data (associated with RPO). This can guide future development of the plan and maintenance of the DRP. Such a quantitative approach would also allow CIOs to compare applicable DRP solutions.
Infants’ neuroelectric responses to missing stimuli: Can missing stimuli be novel stimuli? (1990)

Event‐Related Potentials (ERPs) were recorded as 6‐month‐old infants were presented with a picture whose appearance was cued by a preceding tone. On a subset of these trials the picture was deleted. ERPs reflecting “surprise” to the stimulus deletion were observed on the trial following the deleted trial. These results are discussed in the context of the degree to which physically absent events act as novel events, and the limits of infants’ short‐term memory.
Dioxygen Binding in Iron and Cobalt Picnic Basket Porphyrins (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDioxygen Binding in Iron and Cobalt Picnic Basket PorphyrinsJames P. Collman, Xumu Zhang, Kelvin Wong, and John I. BraumanCite this: J. Am. Chem. Soc. 1994, 116, 14, 6245–6251Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ja00093a026https://doi.org/10.1021/ja00093a026research-articleACS PublicationsRequest reuse permissionsArticle Views934Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Metallo-β-lactamases:  Novel Weaponry for Antibiotic Resistance in Bacteria (2006)

Metallo-beta-lactamases are broad-spectrum zinc enzymes, able to inactivate most clinically useful beta-lactam antibiotics. Their structural and functional diversity has thus far limited the understanding of their catalytic mechanism, therefore thwarting the rational design of a common inhibitor. On the basis of the recent availability of structures of enzyme-product complexes and novel mechanistic studies, here, we attempt to find minimal common elements in different members of this family. In contrast with other metalloenzymes, most of the substrate binding and catalytic power resides in the adequate positioning of one or two Zn(II) ions in the active site, empowered by an unusual flexibility.
A communication architecture for massive multiplayer games (2002)

In this paper we present an approach for a communication architecture based on the publisher/subscriber model. The key issues considered here are scalability, ease of programming and dynamic system evolution. The division of the communication load into distinctive channels allows decoupling the domains of the game enabling the overall system to scale flexibly with the underlying network infrastructure, map size or number of players simultaneously online. Thus our approach is suitable to realize especially huge game-worlds as used in massive multiplayer online games. The underlying publisher/subscriber communication layer provides a high level of abstraction with a lean API therefore dramatically simplifying network programming in the game engine. Due to the fact that the communication is content-based, there is no fixed correlation between the game players and the game backend servers. This permits the dynamic evolution of the system by removing or adding not only players but also game servers and game content on the fly.
<title>Vision-based docking under variable lighting conditions</title> (2000)

This paper describes our progress in near-range (within 0 to 2 meters) ego-centric docking using vision under variable lighting conditions (indoors, outdoors, dusk). The docking behavior is fully autonomous and reactive, where the robot directly responds to the ratio of the number of pixels of two colored fiducials without constructing an explicit model of the landmark. This is similar to visual homing in insects and has a low computational complexity of O(n<SUP>2</SUP>) and a fast update rate. In order to accurately segment the colored fiducials under constrained lighting conditions, the spherical coordinate transform (SCT) color space is used, rather than RGB or HSV, in conjunction with an adaptive segmentation algorithm. Experiments with a daughter robot docking with a mother robot were collected. Results showed that 1) vision-based docking is faster than teleoperation yet equivalent in performance and 2) adaptive segmentation is more robust under challenging lighting conditions, including outdoors.
EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer (2019)

The EPHA2 tyrosine kinase receptor is implicated in tumor progression and targeted therapies resistance. We evaluated EPHA2 as a potential resistance marker to the antiepidermal growth factor receptor (EGFR) monoclonal antibody cetuximab in colorectal cancer. We studied activation of EPHA2 in a panel of human colorectal cancer cell lines sensitive or resistant to anti-EGFR drugs. The <i>in vitro</i> and <i>in vivo</i> effects of ALW-II-41-27 (an EPHA2 inhibitor) and/or cetuximab treatment were tested. Formalin-fixed paraffin-embedded tumor specimens from 82 <i>RAS</i> wild-type (WT) metastatic colorectal cancer patients treated with FOLFIRI + cetuximab as first-line therapy in the CAPRI-GOIM trial were assessed for EPHA2 expression by immunohistochemistry and correlated with treatment efficacy. EPHA2 was differentially activated in colorectal cancer cell lines. Combined treatment with ALW-II-41-27 plus cetuximab reverted primary and acquired resistance to cetuximab, causing cell growth inhibition, inducing apoptosis and cell-cycle G1-G2 arrest. In tumor xenograft models, upon progression to cetuximab, ALW-II-41-27 addition significantly inhibited tumor growth. EPHA2 protein expression was detected in 55 of 82 tumor samples, frequently expressed in less-differentiated and left-sided tumors. High levels of EPHA2 significantly correlated with worse progression-free survival [8.6 months; confidence interval (CI) 95%, 6.4-10.8; vs. 12.3 months; CI 95%, 10.4-14.2; <i>P</i> = 0.03] and with increased progression rate (29% vs. 9%, <i>P</i> = 0.02). A specific EPHA2 inhibitor reverts <i>in vitro</i> and <i>in vivo</i> primary and acquired resistance to anti-EGFR therapy. EPHA2 levels are significantly associated with worse outcome in patients treated with FOLFIRI + cetuximab. These results highlight EPHA2 as a potential therapeutic target in metastatic colorectal cancer.
Role of Poly(diallyldimethylammonium chloride) in Selective Polishing of Polysilicon over Silicon Dioxide and Silicon Nitride Films (2011)

A cationic polymer, poly(diallyldimethylammonium chloride), or PDADMAC (MW ≈ 200,000), at a concentration of 250 ppm was used to enhance polysilicon removal rates (RRs) to ∼600 nm/min while simultaneously suppressing both silicon dioxide and silicon nitride RRs to <1 nm/min, both in the absence or in the presence of ceria or silica abrasives during chemical mechanical polishing (CMP). These results suggest that aqueous abrasive-free solutions of PDADMAC are very attractive candidates for several front-end-of-line (FEOL) CMP processes. Possible mechanisms for the enhancement of poly-Si RR and the suppression of oxide and nitride RRs are proposed on the basis of the RRs, contact angle data on poly-Si films, zeta potentials of polishing pads, polysilicon films, silicon nitride particles, and silica and ceria abrasives, thermogravimetric analysis, and UV-vis spectroscopy data.
Performance Improvisation of Cantilever-type Silicon Micro AccelerationSensors Using Stress Concentration Regions Technique (2007)

Acceleration sensors find applications in missile and competent munitions subsystems.Cantilever-type sensor's sensitivity and bandwidth are dependant on material properties of  thecantilever and structure of proof mass. It is always desired to design a sensor as sensitive aspossible but also maintaining higher bandwidth. In piezoresistive (cantilever-type) accelerometers,various techniques were employed by designers to enhance their sensitivity and bandwidth.Most of these techniques are usually focused on shape and size of either cantilever or proofmass. This paper presents a concept of creating stress concentration regions (SCRs) on thecantilever for enhancing its sensitivity. Five types of structures were simulated to study thebehaviour of piezoresistive sensors with SCRs implementation. Use of SCRs results in substantialincrease in the sensitivity, which is of the order of 1.85 times the nominal sensitivity. It was aimedat maximising sensor's performance factor, which is the product of sensor bandwidth andsensitivity. This study gives new dimension to the ways of improving performance of cantilever-type inertial piezoresistive sensor.
Epitaxial bismuth telluride layers grown on [111] barium fluoride substrates suitable for MQW-growth (1999)

Multi quantum wells and superlattices are discussed as suitable tools for increasing ZT. Best layer quality should be expected only for lattice matched growth. Therefore [111] barium fluoride should be most suitable compared to other common substrates like mica and sapphire, although up to now epitaxial growth of bismuth telluride on [111] barium fluoride with atomically flatness was not achieved. We present the first bismuth telluride-layers reproducibly prepared on [111] barium fluoride substrates using the molecular beam technique. Three essential factors influence the growth of bismuth telluride on barium fluoride: substrate temperature, the flux ratio of Bi/Te and substrate surface preparation itself even for single crystal [111] barium fluoride substrates. These dependencies of growth characteristics and layer properties are reported. AFM and RHEED analysis show suitable layer by layer growth of bismuth telluride with step height of 1 nm as expected from its crystal structure. Step widths of growth terraces are similar to those known from other MQW-suitable systems like IV-VI-compounds. Further X-ray analysis combined with EDX-analysis (single crystals standard) indicates single phase growth with stable stochiometric composition.
Hybrid Variability and Effect of Growth Location on Corn Fiber Yields and Corn Fiber Oil Composition (2000)

ABSTRACT The variability in commercial corn hybrids for corn fiber yields, amounts of extractable oil, and levels of individual and total phytosterol components in corn fiber oil was determined. Also, the effect of growth location on fiber yields, fiber oil content, and the levels of individual and total phytosterol compounds was determined. Significant variation was observed in the commercial hybrids for fiber yield (13.2–16.6%) and fiber oil yield (0.9–2.4%). No significant correlation was observed between fiber and oil yields. Significant variations in the commercial corn hybrids were also observed in the individual phytosterol compounds in corn fiber oil: 2.9–9.2% for ferulate phytosterol esters (FPE); 1.9–4.3% for free phytosterols (St); and 6.5–9.5% for phytosterol fatty acyl esters (St:E). Positive correlations were observed among the three phytosterol compounds in the corn fiber oil ( R = 0.75 for FPE and St:E; 0.48 for St:E and St; and 0.68 for FPE and St). The effect of location on dependent variables was also significant. The same hybrids grown at different locations showed a variation (range) of 4.0–17.5% for FPE, 4.9–12.2% for St:E, and 1.95–4.45% for St. Relative ranking of hybrids with respect to phytosterol composition was consistent for almost all of the growth locations.
Ion‐Beam‐Induced Densification of Zirconia Sol–Gel Thin Films (1993)

Densification of sol–gel zirconia films was achieved using ion implantation instead of conventional heat treatment. Densification was observed with Xe + ‐ion doses as low as 10 14 ions/cm 2 . Ion implantation resulted in hydrogen and carbon losses as measured by forward recoil elastic spectrometry (FRES) and Rutherford backscattering spectrometry (RBS) using 12 C(α,α) 12 C resonance, respectively. The density and chemical composition of the highest‐dose implanted sol–gel films were comparable with those obtained by high‐temperature sintering. The chemical and microstructural modifications in the films were attributed to both electronic interactions and nuclear collisions between the Xe + ions and the target atoms.
Thermal mechanical analysis of frozen solutions of mannitol and some related stereoisomers: evidence of expansion during warming and correlation with vial breakage during lyophilization. (1993)

The mechanical properties of frozen mannitol, L-iditol, dulcitol, and sorbitol solutions were measured as a function of temperature during warming (after freezing) using a thermal mechanical analyzer (TMA). The mannitol sample first underwent a contractive phase starting at 30 degrees C and ending at -25 degrees C. This was followed by an initially rapid, then less rapid expansive phase which continued until melting occurred. These events provide direct evidence that mannitol solutions undergo an expansion during warming after "fast" freezing and also corroborate the vial breakage observed when mannitol solutions are frozen and thawed or freeze-dried in glass vials. Of the other stereoisomers studied, only dulcitol had an expansive phase although at a slower rate than mannitol. Its solution was found to cause vial breakage also but only at fill volumes higher than mannitol fill volumes. TMA is a useful technique for studying dimensional changes in the frozen state, with important implications for solving vial breakage problems in freeze-drying.
Under a cloud (2006)

Subtitle: Although it could take months or even years for two major price-fixing probes to be completed, the shockwaves are already being felt around the industry.
Evaluation of the efficacy and safety of a new device for eye drops instillation in patients with glaucoma (2015)

Eyedrop(®) received a better subjective response regarding the ease of instillation of hypotensive eye drops compared to traditional instillation, especially in patients with no previous experience with eye drops. Using the device did not result in any loss of hypotensive effect or increase in the frequency of side effects.
Optical detection of a single rare-earth ion in a crystal (2012)

Rare-earth-doped laser materials show strong prospects for quantum information storage and processing, as well as for biological imaging, due to their high-Q 4f↔4f optical transitions. However, the inability to optically detect single rare-earth dopants has prevented these materials from reaching their full potential. Here we detect a single photostable Pr(3+) ion in yttrium aluminium garnet nanocrystals with high contrast photon antibunching by using optical upconversion of the excited state population of the 4f↔4f optical transition into ultraviolet fluorescence. We also demonstrate on-demand creation of Pr(3+) ions in a bulk yttrium aluminium garnet crystal by patterned ion implantation. Finally, we show generation of local nanophotonic structures and cell death due to photochemical effects caused by upconverted ultraviolet fluorescence of praseodymium-doped yttrium aluminium garnet in the surrounding environment. Our study demonstrates versatile use of rare-earth atomic-size ultraviolet emitters for nanoengineering and biotechnological applications.
The Changing Brain (2011)

Spinal cord injury can potentially lead to adaptive changes in the sensory and motor cortical areas of the brain.
Researches on the Network Security Evaluation Method Based on BP Neural Network (2014)

This paper first describes the basic theory of BP neural network algorithm, defects and improved methods, establishes a computer network security evaluation index system, explores the computer network security evaluation method based on BP neural network, and has designed to build the evaluation model, and shows that the method is feasible through the MATLAB simulation experiments.
Microporous Decatungstates:  Synthesis and Photochemical Behavior (2001)

Photoreactive decatungstates Na4W10O32 and (nBu4N)4W10O32 were heterogenized inside the silica network via a sol−gel technique, resulting in the Na4W10O32/SiO2 (Na1) and (nBu4N)4W10O32/SiO2 (Q1) composites. The physicochemical properties of as-synthesized composites were measured by UV diffuse reflectance spectrum, Fourier transform infrared, thermogravimetric analysis and differential thermal analysis, inductively coupled plasma-atomic emission spectroscopy, and scanning electron microgragh, suggesting that the structural integrity of the decatungstates has been preserved after incorporation into the silica network. The microporous structures of the Na1 and Q1 were confirmed by the nitrogen adsorption measurements. The photocatalytic behaviors of the composites were studied via degradation and mineralization of organophosphorus pesticide, trichorofon (TCF), under near-UV irradiation and in media where they are insoluble. The photocatalytic behaviors of the Na1 and Q1 were also compared with two silica-supported decatungstates, Na4W10O32−SiO2 (Na2) and (nBu4N)4W10O32−SiO2 (Q2). It indicated that the Na1 had the highest photocatalytic efficiency among four insoluble decatungstates, and the leakage of the catalyst from the support was hardly observed for Na1. Studies on the reaction mechanism indicate that OH• radical attack may be responsible for the degradation and final mineralization of TCF.
Decreased Endogenous Secretory Advanced Glycation End Product Receptor in Type 1 Diabetic Patients (2005)

Circulating esRAGE levels were significantly lower in type 1 diabetic patients than in nondiabetic subjects and were inversely associated with the severity of some diabetic vascular complications.
[Sleep of Caspian seals]. (1984)

ECoG both hemispheres, EOG, neck EMG, ECG and electrical activity of olfactory bulbs were recorded in 4 free moving adult Caspean seals of both sexes. Their sleep on land and in water was compared. The wakefulness occupied 85,5 +/- 1,5% of total recording time, the slow wave sleep--12,8 +/- 1,4% and paradoxical sleep--1,7 +/- 0,2%. Unlike the dolphins, the Caspean seals possess no unihemispheric slow wave sleep. When the seals sleep on the land or on the water surface and do not change their posture for breathing they may breathe without awakening like the terrestrial mammals. But when the seals emerge or change their posture to get nostrils above the water they wake up briefly for respiration period.
Early neurologic deterioration in intracerebral hemorrhage (2004)

Clinical and biologic markers of the inflammatory reaction on admission are predictors of subsequent END, whereas early ICH growth, intraventricular bleeding, and high systolic blood pressure within 48 hours are factors associated with END in patients with spontaneous ICH.
An approach for mining service composition patterns from execution logs (2012)

ABSTRACT A service‐oriented application is composed of multiple Web services to fulfill complex functionality that cannot be provided by individual Web service. The combination of services is not random. In many cases, a set of services are repetitively used together in various applications. We treat such a set of services as a service composition pattern. The quality of the patterns is desirable because of the extensive uses and testing in the large number of applications. Therefore, the service composition patterns record the best practices in designing and developing reliable service‐oriented applications. The execution log tracks the execution of services in a service‐oriented application. To document the service composition patterns, we propose an approach that automatically identifies service composition patterns from various applications using execution logs. We locate a set of associated services using Apriori algorithm and recover the control flows among the services by analyzing the order of service invocation events in the execution logs. We also identify structurally and functionally similar patterns to represent such patterns in a higher level of abstraction regardless of the actual services. A case study shows that our approach can effectively detect service composition patterns. Copyright © 2012 John Wiley & Sons, Ltd.
Purification and Characterization of Two Forms of Fatty Acid ω-Hydroxylase Cytochrome P-450 from Rabbit Kidney Cortex Microsomes1 (1990)

We have previously reported the isolation of two forms of cytochrome P-450 (P-450) with omega-hydroxylase activities toward prostaglandin A (PGA) and fatty acids, designated as P-450ka-1 and P-450ka-2, from kidney cortex microsomes of rabbits treated with di(2-ethylhexyl)phthalate [Kusunose, E. et al. (1989) J. Biochem. 106, 194-196]. In the present work, we have purified and characterized two additional forms of rabbit kidney fatty acid omega-hydroxylase, designated as P-450kc and P-450kd. The purified P-450kc and P-450kd had specific contents of 13 and 16 nmol of P-450/mg of protein, with apparent molecular weights of 52,000 and 55,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), respectively. Both the forms showed absorption maxima at 450 nm in the carbon monoxide-difference spectra for their reduced forms. These P-450s efficiently catalyzed the omega- and (omega-1)-hydroxylation of fatty acids such as caprate, laurate, myristate, and palmitate, in a reconstituted system containing P-450, NADPH-P-450 reductase, and phosphatidylcholine. Cytochrome b5 stimulated the reactions to only a slight extent. They had no detectable activity toward PGA and several xenobiotics tested. The two P-450s showed different peptide map patterns after limited proteolysis with papain or Staphylococcus aureus V8 protease.(ABSTRACT TRUNCATED AT 250 WORDS)