gebhart/patrepeval huggingface dataset:
Critical body weight and sexual maturation. (1977)

A hypothesis offered by Dr. Rose E. Frisch and colleagues at Harvard which suggests that a body the average of which is 30 kg at weight spurt initiation and 48 kg at menarche represents some metabolic rate or signal that triggers maturation is discussed. Numerous animal studies have been cited to support this hypothesis. In subsequent reports on critical weight this group suggested that average estimated amount of total body water and lean body mass did not differ in early or late maturers at menarche although the early maturers were estimated to be proportionately fatter. On the basis of these measurements they proposed that a minimum level of body fat about 17% of body weight is necessary for the onset of menstrual cycles in pubertal girls. Criticisms of these studies are summarized briefly. It is suggested that the weight is actually related to amount of lean body mass or total body protein the greatest contributor to the basic metabolic rate. The attainment of similar body protein proportions in early and late maturing female rats and humans at puberty may indicate the presence of a still to be defined metabolic signal which triggers sexual maturation.
Inkjet printing for solid oxide electrochemical reactors (2018)

The increasing reliance of electricity grids globally on intermittent renewable energy resources necessitates large-scale energy storage to balance supply and demand. This could be achieved by converting surplus electrical energy into chemical bonds, and sequentially vice versa, using high-temperature, reversible solid oxide electrochemical reactors (SOERs). However, SOER performances are limited by irreproducible and unpredictable electrode microstructures when fabricated by conventional composite powder-mixing. Hence, this project aimed to test the hypothesis that inkjet printing, a potentially more environmentally benign fabrication technique, could achieve geometrically reproducible SOER microstructures with predictable, and ultimately enhanced, electrochemical performances. Aqueous-based colloidally stable and printable inks were developed for the conventional SOER materials: yttria-stabilised zirconia (YSZ), gadolinium-doped ceria (CGO), lanthanum strontium manganite (LSM), and NiO. Inkjet-printed LSM deposits from the aqueous-based ink were destroyed by heat treatment, so a butanol-based LSM ink formulation was developed. Inkjet-printed YSZ electrolytes for the SOER: CO/CO2|Ni-YSZ|YSZ (printed)|YSZLSM|LSM|O2 achieved 0.78 A cm-2 at 809 C in electrolysis mode, a performance comparableto that with electrolytes fabricated by powder-mixing. Inkjet printed composite YSZ-LSM electrodes resulted in enhanced electrochemical performances compared to conventionally fabricated electrodes in fuel cell and electrolyser modes with H2 and CO/CO2, respectively; at 788 C, a fuel cell peak power density of 0.69 W cm-2 and an electrolyser current density of 3.3 A cm-2 at the thermoneutral potential difference of ca. 1.5 V, were achieved. To steer 3D geometries to be printed, spatial distributions of overpotentials, gas compositions, and current densities were predicted using finite element models. Inkjet-printed YSZ pillar arrays with diameter and height of ca. 35 and 140 m, respectively, were subsequently inkjet printed with LSM to fabricate the oxygen-electrodes. Their electrochemical performance was ca. 50 % lower than that of the composite YSZ-LSM electrodes, due to LSM detaching from the electrolyte during sintering. To replace the composite electrode support, NiO and LSM inks were used to fabricate the SOER: Ni(O) (printed)|YSZ|LSM (printed). Electrochemical performance was limited by Ni coarsening, but a YSZ pillar support could solve this problem, enabling future SOERs to be completely inkjet-printed.
Strategies in Aliphatic Polyester Synthesis for Biomaterial and Drug Delivery Applications (2006)

Aliphatic polyesters are among the most important class of synthetic polymers for applications in biology due to their biodegradability. However, such polyesters are typically semicrystalline, hydrophobic solids lacking in functionality, such that strategic tailoring of their structure and functionality carries the potential to expand their application base to a wide variety of particular applications. Various synthetic methods have been explored for introducing functional groups into aliphatic polyesters. This chapter will describe a number of these methods reported in the past several years, focusing primarily on examples of controlled ring-opening polymerization of functionalized lactones, and postpolymerization functionalization well-defined materials with controlled end-groups and narrow polydispersities.
Ace Inhibition, Atherosclerosis and Myocardial Infarction --The Aire Study in Practice (1994)

Unlike most cell-types in the body, cardiomyocytes do not replicate in adult life. Consequently myocardial infarction produces irreparable damage to the heart which in turn increases the likelihood of premature death. Recent trials indicate that immediate aspirin and thrombolytic therapy beneficially modify the natural history of myocardial infarction, reducing both short- and long-term mortality rates. However, the occurrence of early heart failure in as many as one third of patients continues to carry with it a particularly poor prognosis. Recent trials with ACE inhibitors indicate that delayed initiation (beyond 24 h) and long-term maintenance treatment of patients selected on the basis of either heart failure (AIRE Study) or an ejection fraction of less than 40% (SAVE Study) result in large reductions in all-cause mortality. Although the exact mechanism of this benefit remains uncertain the reduction of further myocyte death due to reinfarction or gradual toxic attrition has been suggested. The currently unreported ISIS-4 and GISSI-3 should provide additional information as to whether the clinical indications for ACE-inhibitor therapy should be extended to other patient groups.
A novel approach for manufacturing oxide dispersion strengthened (ODS) steel cladding tubes using cold spray technology (2019)

A novel fabrication method of oxide dispersion strengthened (ODS) steel cladding tubes for advanced fast reactors has been investigated using the cold spray powder-based materials deposition process. Cold spraying has the potential advantage for rapidly fabricating ODS cladding tubes in comparison with the conventional multi-step extrusion process. A gas atomized spherical 14YWT (Fe-14%Cr, 3%W, 0.4%Ti, 0.2%Y, 0.01%O) powder was sprayed on a rotating cylindrical 6061-T6 aluminum mandrel using nitrogen as the propellant gas. The powder lacked the oxygen content needed to precipitate the nanoclusters in ODS steel, therefore this work was intended to serve as a proof-of-concept study to demonstrate that free-standing steel cladding tubes with prototypical ODS composition could be manufactured using the cold spray process. The spray process produced an approximately 1-mm thick, dense 14YWT deposit on the aluminum-alloy tube. After surface polishing of the 14YWT deposit to obtain desired cladding thickness and surface roughness, the aluminum-alloy mandrel was dissolved in an alkaline medium to leave behind a free-standing ODS tube. The as-fabricated cladding tube was annealed at 1000 °C for 1 h in an argon atmosphere to improve the overall mechanical properties of the cladding.
System-in-Package: Electrical and Layout Perspectives (2011)

The unquenched thirst for higher levels of electronic systems integration and higher performance goals has produced a plethora of design and business challenges that are threatening the success enjoyed so far as modeled by Moore’s law. To tackle these challenges and meet the design needs of consumer electronics products such as those of cell phones, audio/video players, digital cameras that are composed of a number of different technologies, vertical system integration has emerged as a required technology to reduce the system board space and height in addition to the overall time-to-market and design cost. System-in-package (SiP) is a system integration technology that achieves the aforementioned needs in a scalable and cost-effective way, where multiple dies, passive components, and discrete devices are assembled, often vertically, in a package. This paper surveys the electrical and layout perspectives of SiP. It first introduces package technologies, and then presents SiP design flow and design exploration. Finally, the paper discusses details of beyond-die signal and power integrity and physical implementation such as I/O (input/output cell) placement and routing for redistribution layer, escape, and substrate.
Bonding interactions between three adjacent hydrogen ligands. Preparation and spectroscopic properties of the tantalum and niobium complexes [Ta(H)<sub>3</sub>(C<sub>5</sub>H<sub>5–n</sub>R<sub>n</sub>)<sub>2</sub>](R = SiMe<sub>3</sub>, n= 1 or 2) and [Nb(H<sub>3</sub>)(C<sub>5</sub>H<sub>5–n</sub>R<sub>n</sub>)<sub>2</sub>](n= 1, R = Me or SiMe<sub>3</sub>; n= 2, R = SiMe<sub>3</sub>) (1988)

The new title complexes of tantalum are true hydrides whereas the niobium complexes have bonding interactions among the three hydrogen atoms, as evidenced by short n.m.r. T1 values and unusual couplings 1J(H,H) which vary with temperature from less than 3 to about 100 Hz.
Research on the Chinese Word Segmentation System Based on Incremental Learning (2014)

In order to cope with the increasing size of the training corpus and adapt to the requirements of incremental learning, this paper introduces a feature selection algorithm of maximum entropy model into the research of Chinese word segmentation technology, designs and implements a Chinese word segmentation system based on incremental learning. The experimental results show that the system gradually improves the segmentation accuracy in the incremental learning process which without wasting time to restudy.
Low Temperature Growth of Graphene on Glass by Carbon-Enclosed Chemical Vapor Deposition Process and Its Application as Transparent Electrode (2015)

A novel carbon-enclosed chemical vapor deposition (CE-CVD) to grow high quality monolayer graphene on Cu substrate at a low temperature of 500 °C was demonstrated. The quality of the grown graphene was investigated by Raman spectra, and the detailed growth mechanism of high quality graphene by the CE-CVD process was investigated in detail. In addition to growth of high quality monolayer graphene, a transparent hybrid few-layer graphene/CuNi mesh electrode directly synthesized by the CE-CVD process on a conventional glass substrate at the temperature of 500 °C was demonstrated, showing excellent electrical properties (∼5 Ω/□ @ 93.5% transparency) and ready to be used for optical applications without further transfer process. The few-layer graphene/CuNi mesh electrode shows no electrical degradation even after 2 h annealing in pure oxygen at an elevated temperature of ∼300 °C. Furthermore, the few-layer graphene/CuNi mesh electrode delivers an excellent corrosion resistance in highly corrosive solutions such as electroplating process and achieves a good nucleation rate for the deposited film. Findings suggest that the low temperature few-layer graphene/CuNi mesh electrode synthesized by the CE-CVD process is an excellent candidate to replace indium tin oxide (ITO) as transparent conductive material (TCM) in the next generation.
Visual Experience Induces Long-Term Potentiation in the Primary Visual Cortex (2010)

Stimulus-specific response potentiation (SRP) is a robust form of experience-dependent plasticity that occurs in primary visual cortex. In awake mice, visual evoked potentials (VEPs) recorded in layer 4 of binocular visual cortex undergo increases in amplitude with repeated presentation of a sinusoidal grating stimulus over days. This effect is highly specific to the experienced stimulus. Here, we test whether the mechanisms of thalamocortical long-term potentiation (LTP), induced with a theta burst electrical stimulation (TBS) of the dorsal lateral geniculate nucleus, are sufficient to account for SRP. First, we demonstrate that LTP similarly enhances the amplitude of VEPs, but in a way that generalizes across multiple stimuli, spatial frequencies, and contrasts. Second, we show that LTP occludes the subsequent expression of SRP. Third, we reveal that previous SRP occludes TBS-induced LTP of the VEP evoked by the experienced stimulus, but not by unfamiliar stimuli. Finally, we show that SRP is rapidly and selectively reversed by local cortical infusion of a peptide that inhibits PKMζ, a constitutively active kinase known to maintain NMDA receptor-dependent LTP and memory. Thus, SRP is expressed by the same core mechanisms as LTP. SRP therefore provides a simple assay to assess the integrity of LTP in the intact nervous system. Moreover, the results suggest that LTP of visual cortex, like SRP, can potentially be exploited to improve vision.
Automating information overload (1997)

Article Automating information overload: linking databases to the Web Share on Author: Leonard A. White Technology Training and Resource Specialist, Information Technology Training, U.C. Davis, Davis, CA Technology Training and Resource Specialist, Information Technology Training, U.C. Davis, Davis, CAView Profile Authors Info & Claims SIGUCCS '97: Proceedings of the 25th annual ACM SIGUCCS conference on User services: are you ready?November 1997 Pages 327–331https://doi.org/10.1145/266064.266165Online:09 November 1997Publication History 0citation488DownloadsMetricsTotal Citations0Total Downloads488Last 12 Months1Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
6.8 A 36Gb/s Adaptive Baud-Rate CDR with CTLE and 1-Tap DFE in 28nm CMOS (2019)

Baud-rate clock-and-data recovery circuits (CDR) are ubiquitous in recent receiver designs as a means of lowering power consumption by sampling the data only once per UI. To further reduce power, prior works in pattern-based baud-rate PD [1] and FD [2] combine clock & data recovery by sharing comparators between the DFE and the PD. However, both CDRs [1, 2] were manually tuned by sweeping the equalization settings of the CTLE and the comparator levels in order to achieve lock. Since the two settings are correlated, it is time-consuming and tedious to sweep the entire solution space. In this paper, we propose an adaptive engine where the CDR system searches and converges to an optimal lock and sampling point. The proposed scheme, implemented in 28nm CMOS and operating at 36Gb/s, relies on the data eye to autonomously adapt the parameters of a CTLE, a 1-tap DFE, and the PD locking point.
Growth Per Cycle in Atomic Layer Deposition: A Theoretical Model (Chem. Vap. Deposition 2003, 9, 249) (2004)

Abstract To view the original paper use http://dx.doi.org/10.1002/cvde.200306265 .
An assessment of corrections for eddy covariance measured turbulent fluxes over snow in mountain environments (2009)

Snow‐covered complex terrain is an extremely important runoff‐generating landscape in high‐altitude and high‐latitude environments, yet it is often considered nonviable for eddy covariance measurements of turbulent fluxes. Turbulent flux data are useful for evaluating the coupled snow cover mass and energy balance that control snow ablation and melt. In particular, detailed, multiseason analyses of eddy covariance data postprocessing requirements and resulting data quality for hydrological analyses in open and sheltered mountain sites have not been conducted. These analyses are needed since these landscapes typify those that generate snowmelt runoff in the mountain west of North America. Eddy covariance measurements taken from exposed hilltop and sheltered subcanopy snow research sites during three snow seasons underwent rigorous postprocessing and data quality assessments. Procedures included data filtering, air density corrections, sensor heating, axis rotation, and exclusion of nonstationary data. Data quality analysis showed that 77% of the sensible heat flux data and 95% of the latent heat flux data were of high quality. There was little interannual variability over three seasons in quality or improvements due to postprocessing results. A comparison of summary data based on a 30‐min averaging period to postprocessed high‐resolution flux data found that the postprocessed sensible heat fluxes were up to 14% less than the summary fluxes for the snow season. The results indicated that application of unattended eddy covariance techniques at these sites was viable, but the full suite of corrections and postprocessing are advisable to obtain flux observations of sufficient reliability for snow hydrology calculations.
Real-time experiments in neural identification and control of disturbance (2005)

Designs have been proposed for neural identification and control of dynamic systems with unknown disturbance. These neural designs have been implemented in real-time experiments using a DC motor system with friction as the plant and additive disturbance at the input. The experimental results reveal the capability of neural networks to identify bounded, unknown, periodic disturbance. It also shows the improved performance of the dynamic neural control design as compared to other schemes found in the literature. This control design incorporates a better gradient estimation scheme using a disturbance identification network.
Simulation of Human Small Intestinal Digestion of Starch Using an In Vitro System Based on a Dialysis Membrane Process (2020)

This work deepens our understanding of starch digestion and the consequent absorption of hydrolytic products generated in the human small intestine. Gelatinized starch dispersions were digested with α-amylase in an in vitro intestinal digestion system (<i>i</i>-IDS) based on a dialysis membrane process. This study innovates with respect to the existing literature, because it considers the impact of simultaneous digestion and absorption processes occurring during the intestinal digestion of starchy foods and adopts phenomenological models that deal in a more realistic manner with the behavior found in the small intestine. Operating the <i>i</i>-IDS at different flow/dialysate flow ratios resulted in distinct generation and transfer curves of reducing sugars mass. This indicates that the operating conditions affected the mass transfer by diffusion and convection. However, the transfer process was also affected by membrane fouling, a dynamic phenomenon that occurred in the <i>i</i>-IDS. The experimental results were extrapolated to the human small intestine, where the times reached to transfer the hydrolytic products ranged between 30 and 64 min, according to the flow ratio used. We consider that the <i>i</i>-IDS is a versatile system that can be used for assessing and/or comparing digestion and absorption behaviors of different starch-based food matrices as found in the human small intestine, but the formation and interpretation of membrane fouling requires further studies for a better understanding at physiological level. In addition, further studies with the <i>i</i>-IDS are required if food matrices based on fat, proteins or more complex carbohydrates are of interest for testing. Moreover, a next improvement step of the <i>i-</i>IDS must include the simulation of some physiological events (e.g., electrolytes addition, enzyme activities, bile, dilution and pH) occurring in the human small intestine, in order to improve the comparison with in vivo data.
Wavelets and their Applications (1992)

Contributions discuss signal analysis discrete-time signal processing, wavelets for Quincunx pyramid, transform maxima and multiscale edges, among other topics; numerical analysis; other applications the optical wave transform, continuous wavelet transform, quantum mechanics; and theoretical develop
Brown adipose tissue: the wholy grail of metabolic disease (2014)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Abstract 5563: Targeting the PH domain of TIAM1 to inhibit prostate cancer metastasis. (2013)

Abstract TIAM1 (T-lymphoma invasion and metastasis-inducing protein-1) is a highly conserved guanine nucleotide exchange factor and contains an Dbl Homology (DH)/C-terminal Pleckstrin Homology (PH) domain. The crystal structure of DH-PH of TIAM1 in complex with Rac-1 has been reported. TIAM1 has been found to be over-expressed cancers such as breast, colon and prostate cancers. An increase in TIAM1 expression has been shown to be associated with increased metastatic potential of breast cancer cell lines and is also correlated with poor prognosis of patients with prostate cancer. TIAM1 is thus a novel PH domain-containing drug target directly related to cancer progression, metastasis and patient survival. We have identified and characterized novel small molecule inhibitors targeting the phosphoinositide lipid binding PH domain of TIAM1 in order to selectively inhibit cell migration, invasion and survival. An In Silico screen of our internal and Maybridge library using the crystal structure of TIAM1 has identified 11 compounds that bind to the PH domain. In vitro assays revealed that compounds TPH-3 and TPH-15 significantly reduced the amount of active Rac1 in PC-3 prostate cancer cells (EC50 of 2.73±0.13 and 2.38±0.98 μM) by binding to PH-TIAM1 with high affinity (KD in the micromolar range) using surface plasmon resonance (SPR) spectrometry. Both compounds displaced PtdIns-3,4,5-P3 in a SPR competitive binding assay. TPH-3 and TPH-15 inhibited cell proliferation with EC50 of 19.8±3.2 and 28.7±1.7 μM in prostate cancer cells LnCaP and EC50 of 18.6±1.8 and 33.3±6.7 μM in PC-3. Wound healing assays and lamellipodia formation were both inhibited by the compounds. TPH-15 inhibited ≈70% of PC-3 invasion using a matrigel invasion assay. Finally, TPH-15 exhibits anti-tumor properties in a PC-3 mouse xenograft study (%T/C≈38.8) with good pharmacokinetic properties (T1/2≈5 hours). Cardio-injection of prostate PC-3 cells in SCID mice was used to test the effects of TPH-15 in the prevention of bone metastasis. Mice were treated with 50mg/kg ip of TPH-15 once a day for 5 days. TPH-15-treated mice developed significantly less pelvic bone lesions than the untreated group and TPH-15 treated mice lived longer, on average, than the untreated group. Overall, we have identified novel compounds which exhibit the ability to reduce prostate cancer bone metastasis by binding to the PH domain of TIAM1, an important GEF in the process of metastasis. Citation Format: Emmanuelle J. Meuillet, Sylvestor A. Moses, Jana Jandova, Eugene A. Mash, Shuxing Zhang. Targeting the PH domain of TIAM1 to inhibit prostate cancer metastasis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5563. doi:10.1158/1538-7445.AM2013-5563