gebhart/patrepeval huggingface dataset:
New process models for OPC at sub-90-nm nodes (2003)

At the sub-90nm nodes, model-based OPC accuracy requirements call for highly accurate compact process modeling and modeling strategies. We examined a large number of CD measurement datasets from a variety of 193nm lithography environments to quantify CD contributions from the different processing steps: mask making, resist development and etching. Based on this analysis, we developed a new class of OPC models, called VT5 models, based on the foundation of VTRE models. These physically-based, non-linear OPC models, heuristically capture various propagation, loading, and dissipation effects of silicon processing responsible for CD variability. The VT5 model comprises variable threshold and variable bias forms as functions of the optical image shape and layout density parameters. (Simpler VT5 version without the bias form and densities is reported in Y.Granik, N.Cobb, T.Do, "Universal process modeling with VTRE for OPC", SPIE 2002). We investigated various modeling strategies to streamline OPC model building and optimization. We identified primary optimization candidates among optical and process parameters, stressing model verification as possibly the most important, but often overlooked, step in the model building sequence. Substantial gain in VT5 accuracy comfortably serves the sub-90nm process nodes for the model-based OPC flow within ITRS error budget targets.
Short Hairpin RNA–mediated Selective Knockdown of NaV1.8 Tetrodotoxin-resistant Voltage-gated Sodium Channel in Dorsal Root Ganglion Neurons (2005)

A selective knockdown of NaV1.8 expression in dorsal root ganglion neurons can be attained by short hairpin RNA delivered with lentivirus. This method may provide a new gene therapy approach to controlling neuronal hyperexcitability and pathologic pain.
A spectral Newton-Schur algorithm for the solution of symmetric generalized eigenvalue problems (2020)

This paper proposes a numerical algorithm based on spectral Schur complements to compute a few eigenvalues and the associated eigenvectors of symmetric matrix pencils. The proposed scheme follows an algebraic domain decomposition viewpoint and transforms the generalized eigenvalue problem into one of computing roots of scalar functions. These scalar functions are defined so that their roots are equal to the eigenvalues of the original pencil, and these roots are computed by Newton's method. We describe the theoretical aspects of the proposed scheme and demonstrate its performance on a few test problems.
Amperometric Glucose Biosensing of Gold Nanoparticles and Carbon Nanotube Multilayer Membranes (2007)

Abstract A novel multilayer gold nanoparticles/multiwalled carbon nanotubes/glucose oxidase membrane was prepared by electrostatic assembly using positively charged poly(dimethyldiallylammonium chloride) to connect them layer by layer. The modification process and membrane structures were characterized by atomic force microscopy, scanning electron microscopy and electrochemical methods. This membrane showed excellent electrocatalytic character for glucose biosensing at a relatively low potential (−0.2 V). The K m value of the immobilized glucose oxidase was 10.6 mM. This resulting sensor could detect glucose up to 9.0 mM with a detection limit of 128 μM and showed excellent analytical performance.
Effects of chitosan hydrolyzates on lipid absorption and on serum and liver lipid concentration in rats (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of chitosan hydrolyzates on lipid absorption and on serum and liver lipid concentration in ratsIkuo. Ikeda, Michihiro. Sugano, Katsuko. Yoshida, Eiji. Sasaki, Yasushi. Iwamoto, and Kouta. HatanoCite this: J. Agric. Food Chem. 1993, 41, 3, 431–435Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/jf00027a016https://doi.org/10.1021/jf00027a016research-articleACS PublicationsRequest reuse permissionsArticle Views327Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Stability Analysis and Damping Enhancement Based on Frequency-Dependent Virtual Impedance for DC Microgrids (2016)

This paper focuses on the stability analysis and damping performance improvement of dc microgrids. The small-signal model of a dc microgrid has been derived. Eigenvalue analysis results reveal the relationship between the system stability and different factors of dc microgrids, including types of dc load, the droop coefficient, line parameters, etc. It shows that the poorly damped LC circuits in dc microgrids reduce the system damping and bring in high frequency oscillations. To improve the damping performance, a frequency-dependent virtual impedance approach is proposed, which can effectively shape the high frequency impedance of the dc bus voltage control units, improve the system stability, and mitigate the oscillations. Detailed design guidelines on virtual impedance to achieve good stability and transient performance are also provided. Simulation and experimental results are obtained to confirm the validity of the proposed approach.
<scp><i>L</i></scp><i>isteria monocytogenes</i> exopolysaccharide: origin, structure, biosynthetic machinery and c‐di‐<scp>GMP</scp>‐dependent regulation (2015)

Elevated levels of the second messenger c-di-GMP activate biosynthesis of an unknown exopolysaccharide (EPS) in the food-borne pathogen Listeria monocytogenes. This EPS strongly protects cells against disinfectants and desiccation, indicating its potential significance for listerial persistence in the environment and for food safety. We analyzed the potential phylogenetic origin of this EPS, determined its complete structure, characterized genes involved in its biosynthesis and hydrolysis and identified diguanylate cyclases activating its synthesis. Phylogenetic analysis of EPS biosynthesis proteins suggests that they have evolved within monoderms. Scanning electron microscopy revealed that L. monocytogenes EPS is cell surface-bound. Secreted carbohydrates represent exclusively cell-wall debris. Based on carbohydrate composition, linkage and NMR analysis, the structure of the purified EPS is identified as a β-1,4-linked N-acetylmannosamine chain decorated with terminal α-1,6-linked galactose. All genes of the pssA-E operon are required for EPS production and so is a separately located pssZ gene. We show that PssZ has an EPS-specific glycosylhydrolase activity. Exogenously added PssZ prevents EPS-mediated cell aggregation and disperses preformed aggregates, whereas an E72Q mutant in the presumed catalytic residue is much less active. The diguanylate cyclases DgcA and DgcB, whose genes are located next to pssZ, are primarily responsible for c-di-GMP-dependent EPS production.
Chromium supplementation in overweight and obesity: a systematic review and meta‐analysis of randomized clinical trials (2013)

The increased prevalence of obesity has made the use of dietary supplements as weight reducing agents highly popular, but their efficacy has not been proven. One such supplement is chromium. The purpose of this review was to evaluate the evidence for or against the efficacy of chromium supplementation in overweight and obese individuals. Electronic searches were conducted in Medline, Embase, Amed and The Cochrane Library. The bibliographies of located articles were also searched. No age, gender or language restrictions were imposed. The reporting quality of identified randomized clinical trials (RCTs) was assessed using a methodological checklist adapted from the Consolidated Standard of Reporting Trials Statement and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Thirty-nine trials were identified and 20 were included. There were variations in reporting quality of included studies. A meta-analysis of 11 studies showed a statistically significant difference in weight loss favouring chromium over placebo (mean difference (MD): -0.50 kg; 95% confidence interval (CI): -0.97, -0.03). There was a high statistical heterogeneity. Adverse events included watery stools, vertigo, headaches and urticaria. The evidence from available RCTs shows that chromium supplementation generates statistically significant reductions in body weight. The magnitude of the effect is small, and the clinical relevance is uncertain. Future trials should last at least 16 weeks and greater uniformity in the measuring and assessment tools for body composition is recommended.
Frequency comb generation in III-V-on-silicon photonic integrated circuits (2016)

We present our recent work on the realization of III-V-on-silicon mode-locked lasers and integrated nonlinear waveguides for the realization of integrated frequency combs.
Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours. (2007)

Beclin 1 is is an autophagy gene, the role of which as a tumour suppressor has recently been recognized in a few studies. We examined the expression of Beclin 1 protein in 212 primary human brain tumours, including 97 high-grade glial tumours, 29 low-grade glial tumours, 4 grade III meningiomas, 19 grade II meningiomas, 52 grade I meningiomas, and 11 medulloblastomas. In 94 cases, including 56 glial tumours, 35 meningiomas, and 3 medulloblastomas we also assessed Beclin 1 mRNA expression by real-time RT-PCR. In most high-grade astrocytic, ependymal neoplasms and atypical meningiomas we found a decrease of cytoplasmic protein expression that was, instead, high in the majority of low-grade tumours and in medulloblastomas. The expression level of Beclin 1 mRNA was significantly lower in glioblastomas than in grade II (p=0.04) and grade I (p=0.01) astrocytomas; in grade III than in grade I astrocytomas (p=0.01); in grade II than in grade I meningiomas (p=0.03); and in all glial tumours when compared to all meningiomas (p<0.0001). Cytoplasmic expression is thought to be linked to the functional protein. Our observations are in line with studies that demonstrated decreased expression of Beclin 1 in human breast, ovarian, prostate and ovarian cancer and furtherly support its involvement also in brain tumours, which had previously been demonstrated in a few experimental studies, both in spontaneous and in therapy-induced autophagy. Furthermore, our study suggests possible differences of Beclin 1 involvement and its role among the different histotypes of brain neoplasms. Further studies are needed to highlight Beclin 1 function in tumour suppression and/or in tumour survival through autophagy and other related programmed cell death processes in brain tumours.
Agents are not (just) web services : considering BDI agents and web services ♦ (2005)

Web services and software agents share a motivation of aiming to facilitate more flexible and adaptable I.T. systems. Web services are increasingly being used to provide active behaviour over the Internet, and promise end-user benefits that, in previous work, have been associated with agent systems. Thus it is natural to consider what relationships agents should have to web services. We argue that agents and web services are distinct. In our work, agents provide a distinctive additional capability in mediating user goals to determine service invocations. In this paper, we review some of the design choices for integrating agents and web services, and illustrate one approach using reactive planning to control web-service invocation by BDI agents.
A Deep Visual Correspondence Embedding Model for Stereo Matching Costs (2015)

This paper presents a data-driven matching cost for stereo matching. A novel deep visual correspondence embedding model is trained via Convolutional Neural Network on a large set of stereo images with ground truth disparities. This deep embedding model leverages appearance data to learn visual similarity relationships between corresponding image patches, and explicitly maps intensity values into an embedding feature space to measure pixel dissimilarities. Experimental results on KITTI and Middlebury data sets demonstrate the effectiveness of our model. First, we prove that the new measure of pixel dissimilarity outperforms traditional matching costs. Furthermore, when integrated with a global stereo framework, our method ranks top 3 among all two-frame algorithms on the KITTI benchmark. Finally, cross-validation results show that our model is able to make correct predictions for unseen data which are outside of its labeled training set.
Gender-specific, maturation-dependent effects of testosterone on chondrocytes in culture. (1994)

This study examined the effects of testosterone on chondrocytes in vitro in order to determine whether the effects of testosterone were dependent on the stage of chondrocyte maturation and gender specific. Cells derived from male or female rat costochondral growth zone and resting zone cartilage were used as the cell culture model. [3H]Thymidine incorporation, cell number, alkaline phosphatase specific activity, and percent collagen production were used as indicators. Alkaline phosphatase specific activity in matrix vesicles and plasma membranes isolated from male and female chondrocyte cultures was measured to determine which membrane fraction was targeted by the hormone. The role of fetal bovine serum in the culture medium was also addressed. The results demonstrated that testosterone decreases cell number and [3H]thymidine incorporation in male chondrocytes, suggesting that it may promote differentiation of these cells. Alkaline phosphatase specific activity is stimulated in growth zone cells, with no effect on resting zone cells. The increase in enzyme activity is targeted to the matrix vesicles. Cells cultured in serum-free medium exhibit a dose-dependent inhibition of alkaline phosphatase activity when cultured with testosterone, even in the presence of phenol red. Testosterone-dependent stimulation of enzyme activity is seen only in the presence of serum, suggesting that serum factors are also necessary. Testosterone increased the percent collagen production in male cells only, regardless of the cartilage zone of origin. The results of this study indicate that the effects of testosterone are dependent on the time of exposure, presence of serum, and sex and stage of maturation of the chondrocytes. Testosterone-dependent stimulation of alkaline phosphatase specific activity is targeted to matrix vesicles.
Establishing some Correlations between Certain Morphometric Parameters and Embryo Quality (2011)

The aim of this paper was to establish some correlations between certain morphometric parameters and embryo quality. The morphometric parameters taken into consideration were: zona pellucida thickness, outer and inner diameter, and outer and inner perimeter. For experiments we used embryos recovered at 24 hours from mouse females superovulated with gonadotrope hormones (eCG and hCG). The embryos recovered were cultivated in KSOM media, supplemented with amino acids, and during the in vitro cultivation they were measured at different time intervals for establishing morphometric parameters. The data obtained were statistically analyzed using Minitab 15, using Fitted Line Plot regression that allows testing of the linear and polynomial regression of one variable. After statistical analyze of the data we found that the thickness of the zona pellucida can constitute a morphometric parameter that can be used as an indicator of subsequent development of the 2 cell embryos to morula and blastocyst stage respectively. The other morphometric parameters studied (outer and inner diameter, and outer and inner perimeter) cannot be used as indicators of the embryo development.
An in vitro test of the cell stretch-proliferation hypothesis of renal cyst enlargement. (1995)

In renal cystic disease, fluid accumulation within cyst lumens might stretch cyst walls and in this way stimulate cell proliferation. To test this idea, the effects of mechanical stretch on Madin-Darby canine kidney cells grown as cysts in a hydrated collagen gel or as monolayers on collagen-coated Flexcell membranes were examined. The percentage of cells synthesizing DNA (labeling index) was determined by measuring bromodeoxyuridine incorporation and counting cell numbers. The distension of single cysts for 1 h by the intraluminal injection of saline failed to produce a significant increase in labeling index. The exposure of cysts for 2.5 h to 1 mM dibutyryl cAMP + 0.1 mM isobutylmethylxanthine led to a 37% increase in luminal surface area (due to stimulated fluid secretion) and a 30% increase in labeling index. The stretch (25%) of Madin-Darby canine kidney monolayers approximately doubled the labeling index between 12 and 24 h after starting the stretch. After 48 h, the cell population density was significantly increased (P < 0.001), from 41.9 +/- 0.2 (SE; N = 12) to 48.2 +/- 0.5 (N = 12) cells/10,000 microns2. The labeling index increased linearly with applied stretch, from 7.2 +/- 0.3% (N = 36) with no stretch to 16.2 +/- 1.0% (N = 6) with 30% stretch. Stretch had to be maintained for 8 h or more to produce an increase in labeling index at 18 h. No evidence was obtained for the release of a diffusible growth factor by stretched monolayers. The increase in labeling index induced by stretch was unaffected by 50 microM gadolinium, a stretch-activated channel blocker, but was abolished by 5 micrograms/mL cytochalasin B, an actin microfilament-disrupting agent. It was concluded that prolonged stretch stimulates renal epithelial cells to synthesize DNA. This supports the idea that increased wall tension in renal cysts may stimulate cell proliferation and, thereby, may contribute to cyst enlargement.
New Applications for Iron and Steelmaking Slag (2014)

Iron and steelmaking slag is a by-product of the iron and steelmaking process. Slag has traditionally been used as a component of cement and construction aggregate. NKK has led the industry in promoting the effective use of slag. In this paper, fine concrete aggregate, known as Sandy-S, and slag sand-capping material are introduced as new ap-plications of granulated blast furnace slag. Other innovative uses of steelmaking slag are introduced: large carbon-ated slag blocks, called Marine Blocks, produced by injecting carbon dioxide into slag compact, and potassium sili-cate fertilizer produced by adding a potassium source to steelmaking slag.
Selective chemotaxis of subsets of B lymphocytes from gut-associated lymphoid tissue and its implications for the recruitment of mucosal plasma cells. (1986)

As they differentiate, precursor cells from the gut-associated lymphoid tissue are known to travel via the lymphatic system to the blood and then preferentially to home to various mucosal and exocrine sites such as the lamina propria of the gut and the lactating mammary gland, where they give rise to IgA-secreting plasma cells. The present study, directed at the mechanism by which the circulating precursors of mucosal IgA plasma cells selectively lodge in characteristic locations, explored the hypothesis that such homing is due to a locally produced chemotactic factor and that milk might be a source of such a factor. Subsets of lymphocytes bearing particular surface markers and purified by panning from lymph nodes of mice were examined in a micropore chemotaxis assay to search for the presence of chemotactic activity in mouse milk. The globulin fraction of whey was shown to contain a nondialyzable factor that is chemotactic for IgA (and also IgG)-positive lymphocytes when these are obtained from mesenteric lymph nodes as a source of mucosal-associated lymphoid tissue. Lymphocytes from peripheral lymph nodes, nonmucosal associated, were unaffected as were surface IgM-positive lymphocytes and T lymphocytes obtained from mesenteric nodes. Chemotactic activity for IgA lymphocytes was undetectable in mouse serum. The data are consistent with the idea that precursors of mucosal IgA plasma cells home to mucosal and exocrine sites in response to a specific chemotactic factor elaborated by local differentiated epithelial cells.
The differential production of cytokines by human Langerhans cells and dermal CD14+ DCs controls CTL priming (2012)

We recently reported that human epidermal Langerhans cells (LCs) are more efficient than dermal CD14(+) DCs at priming naive CD8(+) T cells into potent CTLs. We hypothesized that distinctive dendritic cell (DC) cytokine expression profiles (ie, IL-15 produced by LCs and IL-10 expressed by dermal CD14(+) DCs) might explain the observed functional difference. Blocking IL-15 during CD8(+) T-cell priming reduced T-cell proliferation by ∼ 50%. These IL-15-deprived CD8(+) T cells did not acquire the phenotype of effector memory cells. They secreted less IL-2 and IFN-γ and expressed only low amounts of CD107a, granzymes and perforin, and reduced levels of the antiapoptotic protein Bcl-2. Confocal microscopy analysis showed that IL-15 is localized at the immunologic synapse of LCs and naive CD8(+) T cells. Conversely, blocking IL-10 during cocultures of dermal CD14(+) DCs and naive CD8(+) T cells enhanced the generation of effector CTLs, whereas addition of IL-10 to cultures of LCs and naive CD8(+) T cells inhibited their induction. TGF-β1 that is transcribed by dermal CD14(+) DCs further enhanced the inhibitory effect of IL-10. Thus, the respective production of IL-15 and IL-10 explains the contrasting effects of LCs and dermal CD14(+) DCs on CD8(+) T-cell priming.
Drugs for Non-alcoholic Steatohepatitis (NASH): Quest for the Holy Grail (2020)

Nonalcoholic fatty liver disease (NAFLD) is a global epidemic that is likely to become the most common cause of chronic liver disease in the next decade, worldwide. Though numerous drugs have been evaluated in clinical trials, most of them have returned inconclusive results and shown poorly-tolerated adverse effects. None of the drugs have been approved by the Food and Drug Administration for treating biopsy-proven non-alcoholic steatohepatitis (NASH). Vitamin E and pioglitazone have been extensively used in treatment of biopsy-proven nondiabetic NASH patients. Although some amelioration of inflammation has been seen, these drugs did not improve the fibrosis component of NASH. Therefore, dietary modification and weight reduction have remained the cornerstone of treatment of NASH; moreover, they have shown to improve histological activity as well as fibrosis. The search for an ideal drug or 'Holy Grail' within this landscape of possible agents continues, as weight reduction is achieved only in less than 10% of patients. In this current review, we summarize the drugs for NASH which are under investigation, and we provide a critical analysis of their up-to-date results and outcomes.