gebhart/patrepeval huggingface dataset:
Reverse time migration angle gathers using Poynting vectors (2016)

ABSTRACT Angle-domain common-image gathers provide much useful data about the subsurface, such as seismic velocities and amplitude-versus-angle (AVA) information, and they can be manipulated to provide high-quality stacked images. However, the computation of angle gathers for reverse time migration (RTM), the most physically accurate migration algorithm, has proven to be costly in terms of computer time and memory usage. We have developed an algorithm for computing RTM angle gathers in a relatively efficient manner. Our method is based on the construction of the directions of propagation of the source and receiver wavefields, given by the direction of energy flux, known as the Poynting vector. The computation is carried out in the space-time domain, avoiding the need to transform the wavefield to, for example, frequency-wavenumber space, as is needed for methods based on wavefront projection. Given accurate Poynting vectors for source and receiver wavefields, one may compute the local reflection angle and azimuth, as well as the reflector dip and azimuth. An important advantage of our method is that it is based on local direction information at the reflection point, and thus it avoids the loss of resolution and smearing that can occur with some other techniques. A simple implementation of the Poynting-vector method can lead to noisy gathers, with leakage between angle bins, caused by unstable division of the local wavefields. We have developed an efficient technique to mitigate this noise and evaluated examples illustrating the aforementioned smearing issues of the subsurface-offset-based gathers and the improvements in the Poynting-vector gathers arising from our algorithm enhancement. Finally, the use of angle gathers for AVA analysis requires that (relative) amplitudes as a function of angle be correct. To this end, we derive weight functions for computing gathers with the correct AVA behavior. We determine the correctness of these weights by testing them with synthetic data.
Overview of automated sickle cell disease diagnosis by analysis of spatio-temporal cell dynamics in digital holographic microscopy (2019)

We overview a previously reported system for automated diagnosis of sickle cell disease based on red blood cell (RBC) membrane fluctuations measured via digital holographic microscopy. A low-cost, compact, 3D-printed shearing interferometer is used to record video holograms of RBCs. Each hologram frame is reconstructed in order to form a spatio-temporal data cube from which features regarding membrane fluctuations are extracted. The motility-based features are combined with static morphology-based cell features and inputted into a random forest classifier which outputs the disease state of the cell with high accuracy.
Direct growth of graphene on nitride and oxide substrates (2012)

We have directly grown monolayer and few layer graphene on h-BN(0001), MgO(111), and Co <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> (111) by a variety of methods, including chemical or physical vapor deposition (CVD, PVD), or molecular beam epitaxy (MBE). Such capability is critical to the development of graphene charge- and spin-based devices. In each case, the interactions of graphene with the substrate give rise to distinct graphene properties with significant device implications. These effects include substantial n-type doping (graphene/monolayer h-BN(0001)), formation of a 0.5-1eV band gap (graphene/MgO(111), and magnetic polarization of the graphene conduction electrons (graphene/Co <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> (111)). The results on BN and MgO have significant implications for the formation of field effect transistor (FET)-like devices, while the results on Co <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> (111) suggest the feasibility of room temperature spin valves with high magnetoresistance and very low power demands.
Synthesis of certain [6:5:6] linear tricyclic nucleosides as potential antitumor agents (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of certain [6:5:6] linear tricyclic nucleosides as potential antitumor agentsFung-Lung Chung, Karl H. Schram, Raymond P. Panzica, Robert A. Earl, Linda L. Wotring, and Leroy B. TownsendCite this: J. Med. Chem. 1980, 23, 11, 1158–1166Publication Date (Print):November 1, 1980Publication History Published online1 May 2002Published inissue 1 November 1980https://pubs.acs.org/doi/10.1021/jm00185a002https://doi.org/10.1021/jm00185a002research-articleACS PublicationsRequest reuse permissionsArticle Views204Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Seroepidemiology of human herpesvirus 7 in healthy children and adults in Japan (1993)

The isolation of human herpesvirus 7 (HHV-7) from saliva and blood, and the prevalence of antibodies to the virus in healthy individuals were investigated in Japan. By cocultivating samples with phytohemagglutinin-P-stimulated cord blood mononuclear cells, HHV-7 was isolated from the saliva of 1 of 20 children and from 4 of 38 adults but not from their blood. The isolates were confirmed as closely related to RK strain of HHV-7, but not to U1102 (human herpesvirus 6, HHV-6 type A) or Z29 (HHV-6 type B) strains by restriction cleavage patterns of the DNA. The virus antibody of 330 healthy children and adults was measured with an indirect immunofluorescence assay, using one of our isolates (FG7-6). The positivity rate of antibody was 40% in the first 2 months of life, declined during the first 6 months, then gradually increased and was 45% at 1-4 years of age. It reached the highest level (60%) at 11-13 years of age and was maintained until the end of the third decade, then decreased thereafter. Additionally, no simultaneous rise in the antibody titers was observed in 7 virologically confirmed exanthem subitum patients.
Directed evolution of Thermotoga neapolitana xylose isomerase: high activity on glucose at low temperature and low pH (2003)

The Thermotoga neapolitana xylose isomerase (TNXI) is extremely thermostable and optimally active at 95 degrees C. Its derivative, TNXI Val185Thr (V185T), is the most active type II xylose isomerase reported, with a catalytic efficiency of 25.1 s(-1) mM(-1) toward glucose at 80 degrees C (pH 7.0). To further optimize TNXI's potential industrial utility, two rounds of random mutagenesis and low temperature/low pH activity screening were performed using the TNXI V185T-encoding gene as the template. Two highly active mutants were obtained, 3A2 (V185T/L282P) and 1F1 (V185T/L282P/F186S). 1F1 was more active than 3A2, which in turn was more active than TNXI V185T at all temperatures and pH values tested. 3A2 and 1F1's high activities at low temperatures were due to significantly lower activation energies (57 and 44 kJ/mol, respectively) than that of TNXI and V185T (87 kJ/mol). Mutation L282P introduced a kink in helix alpha7 of 3A2's (alpha/beta)8 barrel. Surprisingly, this mutation kinetically destabilized 3A2 only at pH 5.5. 1F1 displayed kinetic stability slightly above that of TNXI V185T. In 1F1, mutation F186S creates a cavity that disrupts a four-residue network of aromatic interactions. How the conformation of the neighboring residues is affected by this cavity and how these conformational changes increase 1F1's stability still remain unclear.
Non-Agonistic Bivalent Antibodies That Promote c-MET Degradation and Inhibit Tumor Growth and Others Specific for Tumor Related c-MET (2012)

The c-MET receptor has a function in many human cancers and is a proven therapeutic target. Generating antagonistic or therapeutic monoclonal antibodies (mAbs) targeting c-MET has been difficult because bivalent, intact anti-Met antibodies frequently display agonistic activity, necessitating the use of monovalent antibody fragments for therapy. By using a novel strategy that included immunizing with cells expressing c-MET, we obtained a range of mAbs. These c-MET mAbs were tested for binding specificity and anti-tumor activity using a range of cell-based techniques and in silico modeling. The LMH 80 antibody bound an epitope, contained in the small cysteine-rich domain of c-MET (amino acids 519-561), that was preferentially exposed on the c-MET precursor. Since the c-MET precursor is only expressed on the surface of cancer cells and not normal cells, this antibody is potentially tumor specific. An interesting subset of our antibodies displayed profound activities on c-MET internalization and degradation. LMH 87, an antibody binding the loop connecting strands 3d and 4a of the 7-bladed β-propeller domain of c-MET, displayed no intrinsic agonistic activity but promoted receptor internalization and degradation. LMH 87 inhibited HGF/SF-induced migration of SK-OV-3 ovarian carcinoma cells, the proliferation of A549 lung cancer cells and the growth of human U87MG glioma cells in a mouse xenograft model. These results indicate that c-MET antibodies targeting epitopes controlling receptor internalization and degradation provide new ways of controlling c-MET expression and activity and may enable the therapeutic targeting of c-MET by intact, bivalent antibodies.
A framework for privacy preserving statistical analysis on distributed databases (2012)

Alice and Bob are mutually untrusting curators who possess separate databases containing information about a set of respondents. This data is to be sanitized and published to enable accurate statistical analysis, while retaining the privacy of the individual respondents in the databases. Further, an adversary who looks at the published data must not even be able to compute statistical measures on it. Only an authorized researcher should be able to compute marginal and joint statistics. This work is an attempt toward providing a theoretical formulation of privacy and utility for problems of this type. Privacy of the individual respondents is formulated using є-differential privacy. Privacy of the marginal and joint statistics on the distributed databases is formulated using a new model called δ-distributional є-differential privacy. Finally, a constructive scheme based on randomized response is presented as an example mechanism that satisfies the formulated privacy requirements.
FITTING OF AUDIO PROCESSORS IN PARTIAL DEAFNESSTREATMENT (2012)

Recently, cochlear implant (CI) eligibility criteria have broadened to include individuals with partial deafness, a condition in which, prior to implantation, a significant amount of low-frequency hearing remains. Cochlear implantation aimed for hearing preservation in partial deafness has been recognized as a new method of partial deafness treatment. However, it is not only hearing preservation that has a great influence on the performance of such users; it is also the fitting of the audio processor consisting of acoustic and electric part. In this paper the authors review results of recent studies that underline the importance of correct fitting of the audio processor in order to achieve good benefits in Electric-Acoustic Stimulation (EAS).
Phase I/II study of dianhydrogalactitol in patients with recurrent malignant glioblastoma multiforme (GBM). (2014)

TPS2109 Background: Median survival for patients with recurrent GBM is < 6 months. Front-line systemic therapy is temozolomide but resistance due to O6-methylguanine-DNA-methyltransferase (MGMT) activity is implicated in poor outcomes. Dianhydrogalactitol (VAL-083) is a structurally unique bi-functional DNA alkylating agent that accumulates in brain tumor tissue. Previous clinical studies suggest that VAL-083 has anti-tumor activity against a range of cancers including GBM. In in vitro studies VAL-083 demonstrated activity in pediatric and adult GBM cell lines, as well as GBM cancer stem cells. Notably, VAL-083 overcomes resistance to MGMT in vitro. In light of extensive safety data from clinical trials and promising efficacy in CNS tumors, DelMar initiated a new clinical studyto establish the maximum tolerated dose (MTD) and identify a dose and dosing regimen for future efficacy trials in GBM. Dose limiting toxicity is expected to be myelosuppression, the management of which has improved in recent years. Early in the development of VAL-083, a cumulative IV dose of 125 mg/m2 delivered in a 35 day cycle in combination with radiation was shown superior to radiation alone in brain cancer (Eagan, et al. 1979). In the present study, the cumulative dose in a 33 day cycle ranges from 9 mg/m2 (cohort 1) to 240 mg/m2 (cohort 7). Five dose cohorts, with the highest 33 day cycle cumulative dose of 120 mg/m2, have completed the trial with no drug-related serious adverse events: MTD was not yet reached. Enrollment for cohort 6 (33 day cumulative dose: 180 mg/m2) has been initiated. The final cohort of this study, cohort 7 (33 day cumulative dose: 240 mg/m2), will be initiated subject to no DLT in cohort 6; the results will determine the design of the safety and efficacy registration trial. Methods: Open-label, single-arm Phase I/II dose-escalation study in patients with histologically-confirmed initial diagnosis of malignant GBM. The study utilizes a 3+3 dose-escalation design. Patients receive VAL-083 IV on days 1, 2, and 3 of a 21 day cycle. GBM patients previously been treated with surgery and/or radiation, if appropriate, must have failed both bevacizumab and temozolomide, unless contraindicated. Clinical trial information: NCT01478178.
Prediction of Total Dietary Fiber by Near-Infrared Reflectance Spectroscopy in Cereal Products Containing High Sugar and Crystalline Sugar (1997)

Crystalline sugar has unique spectral characteristics that influence the near-infrared (NIR) region of the spectrum often used to assess product composition. The current study investigated the potential of expanding an existing NIR spectroscopic calibration for the prediction of total dietary fiber in cereal products to include products with high sugar and crystalline sugar content. Using AOAC Procedure 991.43 as the reference method, an NIRSystems monochromator and ISI software for scanning and data analysis, and a selection algorithm to select representative high-sugar samples, a sugar-expanded partial least-squares model (n = 100) was developed for prediction of dietary fiber. The standard error of cross-validation, R2, standard error of performance (n = 45 independent validation samples), and r2 were 1.88%, 0.98, 1.40%, and 0.99, respectively. The NIR model for prediction of total dietary fiber in cereal products was, thus, expanded to include samples with high sugar and crystalline sugar content. Keywords: Dietary fiber; near-infrared; chemometrics; cereal
V-band Stacked Patch Antenna Phased Array (2022)

MIT Lincoln Laboratory is developing a planar V-band phased array antenna. The radiator is required to provide 15% bandwidth with 30° elevation and 50° azimuth scanning capability with vertical polarization. Due to the high level of integration of the radiator and the RF front-end, the goal for the antenna array is to be integrated on printed circuit board (PCB) technology with the T/R module mounted on the opposing side. This design results in a very tightly integrated radiator and RF distribution network in a multi-layer PCB stack up that utilizes Ormet paste technology. A detailed description of the antenna array and RF feed network will be reviewed.
A Prolific Catalyst for Selective Conversion of Neat Glycerol to Lactic Acid (2016)

We report the synthesis and reactivity of a very robust iridium catalyst for glycerol to lactate conversion. The high reactivity and selectivity of this catalyst enable a sequence for the conversion of biodiesel waste stream to lactide monomers for the preparation of poly(lactic acid). Furthermore, experimental data collected with this system provide a general understanding of its reactive mechanism.
Distributed media control tor multimedia communications services (2003)

Previous work in distributed feature composition architecture has shown that a modular, compositional architecture of feature logic can lead to successful management of feature interaction. It can also promote rapid deployment of new services and third party innovation in a communication network. ECLIPSE is an implementation of DFC that focuses on voice over IP (VoIP) and multimedia over IP. In ECLIPSE, the signaling messages traverse units of feature logic (feature boxes), but by necessity the media data have to take a separate and more direct path. This paper describes a scheme in which the feature boxes can cooperatively control the flow of media in an optimal path, while still maintaining the benefits of the DFC architecture. This scheme supports any desired media connectivity, and is independent of VoIP protocols (e.g. SIP and H.323), or the underlying media switch fabric implementation. This result is also applicable to other component architectures for communications. Comparison is made with other schemes proposed in the literature.
A scanning tunneling microscopy based potentiometry technique and its application to the local sensing of the spin Hall effect (2017)

A scanning tunneling microscopy based potentiometry technique for the measurements of the local surface electric potential is presented. A voltage compensation circuit based on this potentiometry technique is developed and employed to maintain a desired tunneling voltage independent of the bias current flow through the film. The application of this potentiometry technique to the local sensing of the spin Hall effect is outlined and some experimental results are reported.
Raman detection of human macular carotenoid pigments (1998)

Summary form only given. The authors have used resonance Raman scattering as a novel optical technique to measure the concentration of carotenoid pigments in the human retina. Using argon laser excitation they obtained two strong carotenoid resonance Raman signals from human retinal tissues at 1159 and 1525 wave numbers, respectively. The laser power levels are within the limits given by the ANSI standard for ocular exposure (2.7 J/cm/sup 2/), and the obtained signals are free of potentially interfering signals from other molecules in the retinal tissue. Of the approximately 10 carotenoid pigments found in normal human serum, the species lutein and zeaxanthin are concentrated in high amounts in the cells of the human macula, which is a /spl sim/5 mm diameter area of the retina in which the visual acuity is highest. These carotenoids give the macula a characteristic yellow coloration, and it is speculated that their absorption may function as filter to attenuate photochemical damage and/or image degradation under bright UV/blue light exposures. In addition, they are thought to act as free-radical scavenging antioxidants. Studies have shown that there may be a link between macular degenerative diseases, the leading cause of blindness in the elderly in the United States, and the presence or absence of the carotenoid molecules.
TGF-?? MIMICS AND ANTI-TGF-?? REVERSES THE FIBROGENIC AND NEPHROTOXIC EFFECTS OF CYCLOSPORINE (1998)

306 The main limitation to cyclosporin's (CsA) use is the associated nephrotoxicity. We have previously demonstrated that CsA induces transforming growth factor-beta (TGF-β), a multifunctional cytokine which has anti-proliferative as well as fibrogenic properties, both in-vivo and in-vitro. This study was designed to test the hypothesis that TGF-β mediates the upregulation of fibrogenic proteins which could lead to the nephrotoxic effects of CsA. Mice (n = 6) treated with CsA (25 mg/Kg) i.p. daily for 7 days were sacrificed either at 10 or 28 days post last injection. In an identical CsA protocol, a second group of mice was also treated with anti-TGF-β monoclonal antibody on day 7. Control mice for these two groups were treated with oil. To compare the effects of CsA with TGF-β, a third group of mice were also treated with purified TGF-β (150 ng/day for 3 days) and control mice for this latter group were injected with PBS-BSA. The nephrotoxic effects were studied both by direct histopathological changes in periodic acid schiff's reagent stained thin kidney sections as well as intra-renal expression of TGF-β, collagen and fibronectin genes by RT-PCR. TGF-β protein expression in these kidneys was also investigated using immunohistochemistry. CsA induced intra-renal expression of TGF-β, collagen, and fibronectin genes, the induction was neutralized in mice treated with anti-TGF-β antibody. TGF-β protein expression was observed in the tubules, outer cortex and interstitium of the kidneys treated with CsA but not in mice treated with CsA and anti-TGF-β antibody and controls. CsA and TGF-β treatment caused similar histopathological changes of vauolization of epithelial cells in the proximal convoluated tubules and thrombotic microangiopathy (arrows). Manipulation of TGF-β levels by anti-TGF -β mAb treatment could alter in-vivo effect of CsA and changes of vauolization of epithelial cells in the proximal conovulated tubules and thrombotic microangiopathy were not see (arrow). These data demonstrate that the CsA induced fibrogenic gene expression and early histologic changes in the kidney appear to be mediated by TGF-β, suggesting a role for this cytokine in CsA induced nephrotoxicity.Figure
Improved compositions for melt processing (1996)

Melt texture processing of is limited by the slow cooling rate and the high temperatures required. Changing the rare earth can improve the processing conditions. The melting point of can be reduced below the melting point of silver by adding silver, and/or reducing the oxygen partial pressure. The recrystallization rate of is shown to be extremely rapid. For low values of x, solid solutions of may be able to be melt processed rapidly below the melting point of silver.
Withdrawal: Identification of a specific domain required for dimerization of activation-induced cytidine deaminase. VOLUME 281 (2006) PAGES 19115-19123 (2008)

Identification of a Specific Domain Required for Dimerization of Activation-induced Cytidine DeaminaseJournal of Biological ChemistryVol. 281Issue 28PreviewActivation-induced cytidine deaminase (AID) is essential to all three genetic alterations required for generation of antigen-specific immunoglobulin: class switch recombination, somatic hypermutation, and gene conversion. Here we demonstrate that AID molecules form a homodimer autonomously in the absence of RNA, DNA, other cofactors, or post-translational modifications. Studies on serial deletion mutants revealed the minimum region between Thr27 and His56 responsible for dimerization. Analyses of point mutations within this region revealed that the residues between Gly47 and Gly54 are most important for the dimer formation. Full-Text PDF Open Access This article has been withdrawn by the authors.