gebhart/patrepeval huggingface dataset:
A DSP-based zero current and discontinuous conduction mode detection method (2013)

This paper presents a digital signal processor (DSP)-based zero current detection (ZCD) and discontinuous conduction mode (DCM) digital detection method for the boost power factor correction (PFC) converter. The detection technique employs a DSP with integrated high-speed comparators to allow simple detection of zero inductor current and DCM operation. By avoiding the need for auxiliary circuits, inductor windings, and by effectively using DSP resources, the proposed detection technique realizes cost and performance advantages over alternative detection methods. An experimental 650 W boost PFC converter operating in mixed-conduction mode controlled by a TMS320F28035 confirms the effectiveness of the proposed detection technique.
Noninvasive continuous blood pressure monitoring (2015)

We are presenting a novel photoplethysmographic (PPG) optical sensor and device with ambient optical, electrical and electromagnetic noises cancellation, thus allowing only the useful optical signals to be received by the health monitoring device. We are also presenting a new processing technique for canceling the ambient noises contributed by optical, electrical and electromagnetic artifacts in the measured PPG signals. Such a device and method allow the enhancement of the performance of the PPG sensors compared to conventional apparatus and methods. The presented sensor and methodology have been integrated into a prototype standalone device for noninvasive, continuous, wearable, remote and mobile monitoring of blood pressure and other human vital signs, such as heart rate, oxygen saturation, respiration rate, etc This small device allows the user to read, store, process and transmit all the measurements made using the PPG optical sensor and the electronic unit to a remote location.
State-Variable Steady-State Analysis of a Controlled Current Induction Motor Drive (1975)

The exact equations defining steady-state operation of a controlled current induction motor drive system are derived by solving the system state equations in the stationary reference frame. These equations, which assume ideal current filtering, eliminate the difficulties involved in taking derivatives of discontinuous currents by defining a pair of pseudocurrent variables. Effects of saturation are included by using the slope ratio method. Electromagnetic torque and current pulsations are computed for various load conditions, and experimental confirmation of the calculated results is made. Similarities and differences to voltage controlled characteristics are presented. It is shown that normal open-loop operation occurs on the unstable side of the torque-slip characteristic necessitating the use of feedback control for stable operation.
Discovering natural language commands in multimodal interfaces (2019)

Discovering what to say and how to say it remains a challenge for users of multimodal interfaces supporting speech input. Users end up "guessing" commands that a system might support, often leading to interpretation errors and frustration. One solution to this problem is to display contextually relevant command examples as users interact with a system. The challenge, however, is deciding when, how, and which examples to recommend. In this work, we describe an approach for generating and ranking natural language command examples in multimodal interfaces. We demonstrate the approach using a prototype touch- and speech-based image editing tool. We experiment with augmentations of the UI to understand when and how to present command examples. Through an online user study, we evaluate these alternatives and find that in-situ command suggestions promote discovery and encourage the use of speech input.
TRINITY: Tailoring Wireless Transmission Strategies to User Profiles in Enterprise Wireless Networks (2016)

The proliferation of smartphones and tablet devices is changing the landscape of user connectivity and data access from predominantly static users to a mix of static and mobile users. While significant advances have been made in wireless transmission strategies (e.g., beamforming and network MIMO) to meet the increased demand for capacity, such strategies primarily cater to static users. To cope with growing heterogeneity in data access, it is critical to identify and optimize strategies that can cater to users of various profiles to maximize system performance and more importantly, improve users' quality of experience. Toward this goal, we first show that users can be profiled into three distinct categories based on their data access (mobility) and channel coherence characteristics. Then, with real-world experiments, we show that the strategy that best serves users in these categories varies distinctly from one profile to another and belongs to the class of strategies that emphasize either multiplexing (e.g., network MIMO), diversity (e.g., distributed antenna systems) or reuse (e.g., conventional CSMA). Two key challenges remain in translating these inferences to a practical system, namely: 1) how to profile users and 2) how to combine strategies to communicate with users of different profiles simultaneously. In addressing these challenges, we present the design of TRINITY-a practical system that effectively caters to a heterogeneous set of users. We implement and evaluate a prototype of TRINITY on our WARP radio testbed. Our extensive experiments show that TRINITY's intelligent combining of transmission strategies improves the total network rate by 50%-150%, satisfies the QoS requirements of thrice as many users, and improves PSNR for video traffic by 10 dB compared with individual transmission strategies.
An efficient means to mitigate wavefront curvature effects in polar format processed SAR imagery (2012)

Synthetic aperture radar (SAR) images processed using the polar format algorithm (PFA) may exhibit distortion if the curvature of the spherical wavefronts are not accounted for. The distortion manifests in geometric shifts and defocusing of targets, and intensifies as distances between pixels and the scene reference position increase. In this work, we demonstrate a method to mitigate the effects of wavefront curvature by applying localized (space-variant) phase corrections to sub-regions selected from the polar format processed image. The modified sub-images are then reassembled into a full image. To minimize discontinuities in the reconstructed image, the spatially variant phase adjustments are made to regions larger than the sub-images, and pared down before being reinserted into the complete image. The result is a SAR process that retains the efficiency of the PFA, yet avoids scene size limitations due to wavefront curvature distortions. The method is illustrated and validated using simulations and real data collected by the General Atomics Aeronautical Systems, Inc. (GA-ASI) Lynx® Multi-mode Radar System.
Engineering Bacterial Phenylalanine 4-Hydroxylase for Microbial Synthesis of Human Neurotransmitter Precursor 5-Hydroxytryptophan (2014)

5-Hydroxytryptophan (5-HTP) is a drug that is clinically effective against depression, insomnia, obesity, chronic headaches, etc. It is only commercially produced by the extraction from the seeds of Griffonia simplicifolia because of a lack of synthetic methods. Here, we report the efficient microbial production of 5-HTP via combinatorial protein and metabolic engineering approaches. First, we reconstituted and screened prokaryotic phenylalanine 4-hydroxylase activity in Escherichia coli. Then, sequence- and structure-based protein engineering dramatically shifted its substrate preference, allowing for efficient conversion of tryptophan to 5-HTP. Importantly, E. coli endogenous tetrahydromonapterin (MH4) could be utilized as the coenzyme, when a foreign MH4 recycling mechanism was introduced. Whole-cell bioconversion allowed the high-level production of 5-HTP (1.1-1.2 g/L) from tryptophan in shake flasks. On this basis, metabolic engineering efforts were further made to achieve the de novo 5-HTP biosynthesis from glucose. This work not only holds great scale-up potential but also demonstrates a strategy for expanding the native metabolism of microorganisms.
Dengue Virus Infection of Human Endothelial Cells Leads to Chemokine Production, Complement Activation, and Apoptosis (1998)

Dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) are severe complications of secondary dengue virus (DV) infection. Vascular leakage, hemorrhagic diathesis and complement activation are the hallmarks of the disease. The short-lived nature of the plasma leakage syndrome has led to the conclusion that altered permeability is most likely effected by a soluble mediator. In the present study, we show that infection of human endothelial cells with DV induces the transcriptional up-regulation and secretion of RANTES and IL-8 and, in the presence of anti-dengue Abs, the formation of nonlytic complement complexes. Extremely high levels of IL-8 were detected in plasma and pleural fluid samples from patients with DSS. Furthermore, DV infection of endothelial cells in vitro caused apoptosis. Complement activation, chemokine induction, and apoptotic cell death may act in concert to cause the fulminant but short-lived vascular leakage that is characteristic of DHF/DSS.
A murine model for B-lymphocyte somatic cell gene therapy. (1994)

Mature primary B lymphocytes represent a potentially important cellular target for somatic cell gene therapy, which could prove advantageous for the treatment of certain metabolic and immunologic disorders. Their capacity to serve as antigen-presenting cells could be utilized for triggering and/or potentiating immune responses to tumors and viruses. Alternatively, B cells expressing an autoantigen could be manipulated to induce antigen-specific unresponsiveness for treatment of autoimmune diseases. Efficient expression of an exogenous gene product in long-lived B lymphocytes could be particularly useful for providing a corrected gene product in the bloodstream. Despite these advantages, efficient gene transfer into mature primary B cells has not been reported. One reason for this is that current protocols for retroviral vector-mediated gene transfer into lymphocytes rely on in vitro expansion and/or drug selection. This precludes the use of mature primary B cells as targets, since they cannot be readily cultured for long periods of time. In this report, we describe an efficient and rapid protocol for the introduction of exogenous genes into primary B cells without the need for drug selection. We have used retroviral vectors containing the human adenosine deaminase gene as a marker gene, since the biological activity of this enzyme is easy to measure and is readily distinguishable from that of the endogenous mouse adenosine deaminase. Upon adoptive transfer into SCID mice, infected B cells continuously expressing one to three copies of the human adenosine deaminase gene could be found in the spleens of recipient animals for at least 3 months.
Abstract 457: Matrix metalloproteinase-2 modulates antitumor immunity. (2013)

Abstract Background: Cancer cells, including melanoma, can be highly resistant to traditional treatments such as chemotherapy and radiotherapy. As a result, a lot of effort has been put into developing immune therapies to treat cancer patients. The main barrier to design effective immunotherapies is the immunosuppression induced by the tumor. Matrix metalloproteinase-2 (MMP-2) is over-expressed in most cancers including melanoma, and its expression is associated with increased dissemination and poorer survival/prognosis. Here, we not only uncovered an immunosuppressive role of MMP-2 in inducing ineffective/detrimental TH2 immune responses, but also the underlying mechanisms. Methods: Human dendritic cells (DCs) were cultured in the presence of MMP-2 and/or various TLR agonists. DCs responses were monitored using immunostaining, ELISA or cytometric bead array methods. Autologous CD4+ T cells were stimulated using these conditioned tumor-associated antigen (TAA)-pulsed DCs. TAA-specific CD4+ T cells were cloned and characterized using mainly the same techniques as for DCs. Results: Here we showed that MMP-2-conditioned human DCs primed naïve CD4+ T cells to differentiate into an inflammatory TH2 phenotype, i.e. mainly secreting TNFα, IL-4 and IL-13 and expressing GATA3. Accordingly, we detected MMP-2-specific CD4+ T cells displaying the same inflammatory TH2 profile in tumor-infiltrating lymphocytes from melanoma patients. We revealed the underlying mechanisms: on the one hand, MMP-2 was found to degrade the type-I IFN receptor IFNAR1, thereby preventing STAT1 phosphorylation, which is necessary for IL-12 production. On the other hand, MMP-2 triggers the Toll-like receptor (TLR)-2 on DCs, which leads to NF-κB activation and OX40L expression. Both lack of IL-12 and over-expression of OX40L were found responsible for skewing T cell responses towards a detrimental TH2 phenotype. Conclusions: MMP-2, therefore, acts as an endogenous TH2 "conditioner" and may underlie the prevalence of detrimental TH2 responses in cancer. Our findings also described the responsible MMP-2-dependent mechanisms, which open the way to novel therapeutic strategies and/or targets to skew anti-tumor CD4+ T cell responses towards a more efficient anti-tumor TH1 phenotype to treat cancer patients. Citation Format: Emmanuelle Godefroy, Anne Gallois, Olivier Manches, Shaheen Ensanyat, Francine Jotereau, Nina Bhardwaj. Matrix metalloproteinase-2 modulates antitumor immunity. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 457. doi:10.1158/1538-7445.AM2013-457
<title>Bioluminescent bioreporter integrated circuits (BBICs)</title> (1998)

As the workhorse of the integrated circuit (IC) industry, the capabilities of CMOS have been expanded well beyond the original applications. The full spectrum of analog circuits from switched-capacitor filters to microwave circuit blocks, and from general-purpose operational amplifiers to sub- nanosecond analog timing circuits for nuclear physics experiments have been implemented in CMOS. This technology has also made in-roads into the growing area of monolithic sensors with devices such as active-pixel sensors and other electro-optical detection devices. While many of the processes used for MEMS fabrication are not compatible with the CMOS IC process, depositing a sensor material onto a previously fabricated CMOS circuit can create a very useful category of sensors. In this work we report a chemical sensor composed of bioluminescent bioreporters (genetically engineered bacteria) deposited onto a micro-luminometer fabricated in a standard CMOS IC process. The bioreporter used for this work emitted 490-nm light when exposed to toluene. This luminescence was detected by the micro- luminometer giving an indication of the concentration of toluene. Other bioluminescent bioreporters sensitive to explosives, mercury, and other organic chemicals and heavy metals have been reported. These could be incorporated (individually or in combination) with the micro-luminometer reported here to form a variety of chemical sensors.
Low-Permeability Laboratory Measurements by Nonsteady-State and Conventional Methods (1983)

Abstract Evaluation of tight gas reservoirs requires an accurate but rapid and practical method to determine permeability. Such a method is presented for determining both specific and effective gas permeability in the 0.0001- to 0.35-md range for plug-size core samples. Equipment is described that meets the requirements for calculation of nonsteady-state flow and incorporates the capability of simulating high net overburden pressures by either hydrostatic or triaxial confining pressures with ease of operation. The time required to collect data and calculate Klinkenberg permeability is typically less than 6 minutes per sample. Values normally differ by less than ±5% from those obtained by steady-state methods. This method is well suited for routine laboratory determinations of permeability on samples from reservoirs with tight or very low gas permeability. Effective gas permeabilities on samples containing nearly irreducible water saturations and the water permeabilities presented are closer to the Klinkenberg permeability values in low-permeability samples than most previously reported.
Uniform Macroporous Ceramics and Plastics by Emulsion Templating (1998)

Macroporous materials with highly uniform pores in the range 50 nm to 20 μm and of any desired porosity up to 90% can be produced using the method introduced here—emulsion templating. The Figure shows an extremely porous poly(acrylamide) gel, one of the many types of materials that can be synthesized using this versatile technique.
The IEEE 1584-2002 Arc Modeling Debate and Simple Incident Energy Equations for Low-Voltage Systems (2006)

The data set and equations presented in the IEEE Standard 1584-2002, IEEE Guide for performing arc-flash hazard calculations, were examined in previous work by the authors. Simple estimations for predicting arc current and incident energy were also presented. This work furthers the understanding of arcing by comparing theoretical circuit results with the low-voltage data published in IEEE 1584-2002. The applicability of popular approaches to arc modeling is discussed. Also, simple formulas for predicting the incident energy released by three-phase arcing faults in low-voltage (<1 kV) systems are validated and compared with results based on IEEE 1584-2002 equations. The role of arc duration in predicting incident energy is addressed
Degradation of pentaerythritol tetranitrate by Enterobacter cloacae PB2 (1996)

A mixed microbial culture capable of metabolizing the explosive pentaerythritol tetranitrate (PETN) was obtained from soil enrichments under aerobic and nitrogen-limiting conditions. A strain of Enterobacter cloacae, designated PB2, was isolated from this culture and was found to use PETN as a sole source of nitrogen for growth. Growth yields suggested that 2 to 3 mol of nitrogen was utilized per mol of PETN. The metabolites pentaerythritol dinitrate, 3-hydroxy-2,2-bis-[(nitrooxy)methyl]propanal, and 2,2-bis-[(nitrooxy)methyl]-propanedial were identified by mass spectrometry and 1H-nuclear magnetic resonance. An NADPH-dependent PETN reductase was isolated from cell extracts and shown to liberate nitrite from PETN, producing pentaerythritol tri- and dinitrates which were identified by mass spectrometry. PETN reductase was purified to apparent homogeneity by ion-exchange and affinity chromatography. The purified enzyme was found to be a monomeric flavoprotein with a M(r) of approximately 40,000, binding flavin mononucleotide noncovalently.
Tetrasialoganglioside GQ1b Reactive Monoclonal Antibodies: Their Characterization and Application for Quantification of GQ1b in Some Cell Lines of Neuronal and Adrenal Origin(S) (1990)

Seven monoclonal antibodies (MAbs) directed to tetrasialoganglioside (GQ1b) were established, purified GQ1b being used for immunization and hybridoma screening. All of the MAbs reacted strongly with GQ1b, although they also reacted with other gangliosides, with different specificities and reactivities. Some MAbs (1H10, 2C7, and 3F4) reacted with GD3, GT1a, GQ1b, and GP1c. MAb 1H4 showed broad specificity. It reacted with GD3, GD1b, GD2, GT1a, GT1b, GO1b, GQ1c, and GP1c. MAbs 7F5, 4E7, and 4F10 recognized GT1a, GQ1b, and GP1c. MAb 4F10 was more specific for GQ1b than the other MAbs. Using MAb 4F10, we determined, by means of an immunoassay, the quantities of endogenous GQ1b in some neuronal and adrenal cell lines, GOTO (human neuroblastoma), Neuro2a (mouse neuroblastoma), and PC12 (rat pheochromocytoma). PC12 and Neuro2a cells contained at least 5.1 X 10(6) and 3.9 X 10(5) molecules/cell of GQ1b, respectively. In contrast, no GQ1b was detected in GOTO cells, which are known for their specific neuritogenic response to this particular ganglioside when exogenously added.
Theseos: A Query Engine for Traceability across Sovereign, Distributed RFID Databases (2007)

The ability to trace the history of individual products, especially their movement through supply and distribution chains, is key to many solutions such as targeted recalls and counterfeit detection. In most traceability applications a number of independent organizations have to work together. EPCglobal has proposed an architecture for a network of RFID databases where each database provides a standardized query interface. That architecture facilitates simple retrieval of traceability data from individual repositories, but it does not support complex traceability queries or cross-organizational query processing. Theseos (R. Agrawal, 2006) provides traceability applications with the ability to execute complex traceability queries that may span multiple RFID databases.
Exceptional Stability and High Hydrogen Uptake in Hydrogen-Bonded Metal−Organic Cubes Possessing ACO and AST Zeolite-<i>like</i> Topologies (2009)

Herein we detail a novel approach for targeting zeolite-like metal-organic frameworks (ZMOFs) that utilizes metal-organic cubes, which are regarded as double four-membered rings (d4Rs) and are composite building units (BUs) in traditional inorganic zeolites. Accordingly, we outline the successful implementation of this strategy by reporting two ZMOFs with ACO and AST zeolite-like topologies, which were constructed from d4R BUs exclusively held together by hydrogen bonds. Their porosity was evaluated, delineating high hydrogen uptake and exceptional stability for the two hydrogen-bonded materials.
Frequency domain ultrasound waveform tomography: breast imaging using a ring transducer (2015)

Application of the frequency domain acoustic wave equation on data acquired from ultrasound tomography scans is shown to yield high resolution sound speed images on the order of the wavelength of the highest reconstructed frequency. Using a signal bandwidth of 0.4-1 MHz and an average sound speed of 1500 m s(-1), the resolution is approximately 1.5 mm. The quantitative sound speed values and morphology provided by these images have the potential to inform diagnosis and classification of breast disease. In this study, we present the formalism, practical application, and in vivo results of waveform tomography applied to breast data gathered by two different ultrasound tomography scanners that utilize ring transducers. The formalism includes a review of frequency domain modeling of the wave equation using finite difference operators as well as a review of the gradient descent method for the iterative reconstruction scheme. It is shown that the practical application of waveform tomography requires an accurate starting model, careful data processing, and a method to gradually incorporate higher frequency information into the sound speed reconstruction. Following these steps resulted in high resolution quantitative sound speed images of the breast. These images show marked improvement relative to commonly used ray tomography reconstruction methods. The robustness of the method is demonstrated by obtaining similar results from two different ultrasound tomography devices. We also compare our method to MRI to demonstrate concordant findings. The clinical data used in this work was obtained from a HIPAA compliant clinical study (IRB 040912M1F).
Large Angle-of-Attack Missile Control Concepts for Aerodynamically Controlled Missiles (1977)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.