gebhart/patrepeval huggingface dataset:
Automated volumetric segmentation of retinal fluid on optical coherence tomography (2016)

We propose a novel automated volumetric segmentation method to detect and quantify retinal fluid on optical coherence tomography (OCT). The fuzzy level set method was introduced for identifying the boundaries of fluid filled regions on B-scans (x and y-axes) and C-scans (z-axis). The boundaries identified from three types of scans were combined to generate a comprehensive volumetric segmentation of retinal fluid. Then, artefactual fluid regions were removed using morphological characteristics and by identifying vascular shadowing with OCT angiography obtained from the same scan. The accuracy of retinal fluid detection and quantification was evaluated on 10 eyes with diabetic macular edema. Automated segmentation had good agreement with manual segmentation qualitatively and quantitatively. The fluid map can be integrated with OCT angiogram for intuitive clinical evaluation.
Immunologic Diagnosis of Tuberculosis (2000)

Evaluation of new vaccines against tuberculosis requires diagnostic tools for accurately identifying asymptomatic individuals infected with Mycobacterium tuberculosis and persons with active tuberculosis. This article discusses limitations of current methods for the immunologic diagnosis of latent infection and active disease and presents novel approaches to developing skin tests and serodiagnostic assays based on "cocktails" of multiple antigens of M. tuberculosis.
SVC-Based Multi-User Streamloading for Wireless Networks (2016)

In this paper, we present an approach for joint rate allocation and quality selection for a novel video streaming scheme called streamloading. Streamloading is a recently developed method for delivering high-quality video without violating copyright enforced restrictions on content access for video streaming. In regular streaming services, content providers restrict the amount of viewable video that users can download prior to playback. This approach can cause inferior user experience due to bandwidth variations, especially in mobile networks with varying capacity. In streamloading, the video is encoded using scalable video coding, and users are allowed to pre-fetch enhancement layers and store them on the device, while base layers are streamed in a near real-time fashion ensuring that buffering constraints on viewable content are met. We begin by formulating the offline problem of jointly optimizing rate allocation and quality selection for streamloading in a wireless network. This motivates our proposed online algorithms for joint scheduling at the base station and segment quality selection at receivers. The results indicate that streamloading outperforms the state-of-the-art streaming schemes in terms of the number of additional streams we can admit for a given video quality. Furthermore, the quality adaptation mechanism of our proposed algorithm achieves a higher performance than baseline algorithms with no (or limited) video-centric optimization of the base station's allocation of resources, e.g., proportional fairness.
Novel Immunoreactive Glycoprotein Orthologs of <i>Ehrlichia</i> spp. (2003)

We previously identified a strongly immunoreactive 43 kDa protein (p43) of Ehrlichia canis. As an immunodiagnostic antigen, the p43 had a 96% accuracy as compared with IFA and provided species-specific diagnosis of E. canis infections. Further investigation has revealed that the E. canis p43 represents the N-terminal portion of the largest immunoreactive protein described in Ehrlichia spp. with a predicted molecular mass of 153 kDa. Analysis of the recombinant N-terminal region (p43) of the p153 by protein gel electrophoresis demonstrated a larger than predicted molecular mass (approximately 30%), and presence of carbohydrate glycans, indicating that the p153 is a glycoprotein. A BLASTn search was performed on the E. chaffeensis genome sequence (95%), and the gene encoding the p153 ortholog was identified in E. chaffeensis. The E. canis p153 (4,263 bp) and E. chaffeensis p156 (4,389 bp) genes had similar chromosomal locations, downstream of the homologous (approximately 87%) deoxyguanosine-triphosphate triphosphohydrolase genes, and homologous (approximately 90%) intergenic sequences preceding the open reading frames. Nucleic acid sequence homology (52%) observed between the glycoprotein genes supported previous findings with regard to genetic divergence of the p43 gene fragment, and the p153 and p156 proteins had amino acid similarity of 32%. A native E. canis protein with a molecular mass of 200 kDa reacted with antisera produced against the N-terminal region (p43) of the p153, suggesting that the native protein was posttranslationally modified. Similarly, recombinant constructs of E. chaffeensis p156 migrated larger than predicted (approximately 200 kDa), and carbohydrate was detected on the recombinant proteins. The chromosomal location, amino acid homology, and biophysical properties support the conclusion that the p153 and p156 glycoproteins (designated gp200s) are species-specific immunoreactive orthologs.
Gaze360: Physically Unconstrained Gaze Estimation in the Wild (2019)

Understanding where people are looking is an informative social cue. In this work, we present Gaze360, a large-scale remote gaze-tracking dataset and method for robust 3D gaze estimation in unconstrained images. Our dataset consists of 238 subjects in indoor and outdoor environments with labelled 3D gaze across a wide range of head poses and distances. It is the largest publicly available dataset of its kind by both subject and variety, made possible by a simple and efficient collection method. Our proposed 3D gaze model extends existing models to include temporal information and to directly output an estimate of gaze uncertainty. We demonstrate the benefits of our model via an ablation study, and show its generalization performance via a cross-dataset evaluation against other recent gaze benchmark datasets. We furthermore propose a simple self-supervised approach to improve cross-dataset domain adaptation. Finally, we demonstrate an application of our model for estimating customer attention in a supermarket setting. Our dataset and models will be made available at http://gaze360.csail.mit.edu.
Analysis and Simulation of an Exoskeleton Controller that Accommodates Static and Reactive Loads (2006)

Exoskeletons are structures of rigid links mounted on the body that promise to restore, rehabilitate, or enhance the human motor function. A major challenge in the practical use of exoskeletons for daily activities relate to the coupled control of human-exoskeleton system. This paper provides a method to resolve the control problem by relegation of the human control and exoskeleton control to two control subsystems. The first subsystem represents the execution of voluntary control from commands generated from the central nervous system. This subsystem is responsible primarily for the kinetic or dynamic components of the motion, including motion generation. The second subsystem represents the exoskeleton controller, responsible for joint level accommodation of all gravitational, static, and certain reactive forces. If all such forces are static, the exoskeleton controller can be viewed as a compensator that maintains the body in static equilibrium. The proposed strategy provides a clear partition between natural voluntary control by the CNS, and artificial assist by the exoskeleton controller. Two methods are presented for implementation of the proposed control algorithm. The first method is based on the principal of virtual work. The second method is a recursive algorithm based on force and moment balance equations. Analytical results are presented to study feasibility regions of exoskeleton control strategies in terms of mechanical efficiency. Finally, simulation results are presented to demonstrate the efficacy of the algorithm for a powered ankle-foot orthosis application.
Inhibin A-subunit cDNAs from porcine ovary and human placenta. (1986)

Inhibin, a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone, has been isolated from porcine follicular fluid and characterized as a 32-kDa protein composed of 18-kDa and 14-kDa subunits. In the present work, oligonucleotide probes predicted from amino-terminal inhibin amino acid sequences have been used to isolate, from a porcine ovarian lambda gt11 cDNA library, clones encoding the 18-kDa subunit, or A chain, of inhibin. DNA sequence analysis showed that the inhibin A chain is initially synthesized as a larger precursor protein and is predicted to be a glycopeptide. Inhibin A-chain mRNA is present specifically in the gonads, and its synthesis can be induced by treatment of the animal with gonadotropins. The porcine probe was used to isolate a human inhibin A-subunit cDNA from a placental cDNA library. The human precursor is highly homologous to its porcine counterpart and is predicted to generate an 18-kDa glycosylated inhibin A subunit.
Abstract 1854: Lysophosphatidic Acid Acyltransferase-Beta contributes to proliferation and anchorage-independent growth in pancreatic adenocarcinoma (2012)

Abstract Abstract: Lysophosphatidic acid acyltransferase-beta (LPAAT-α) catalyzes the production of phosphatidic acid (PA) from lysophosphatidic acid (LPA). PA is a lipid cofactor that contributes to the activation of c-Raf, BRAF, mTOR and PKC-α. LPAAT-α expression is a prognostic factor in gynecologic malignancies and is being investigated as a therapeutic target in a variety of tumor types. We previously reported that LPAAT-α is expressed in pancreatic cancer cell lines and in human pancreatic adenocarcinoma tissues. We employed siRNA knockdown of LPAAT-α expression in pancreatic cancer cells in vitro. We find that reduction in the expression of LPAAT-α protein is associated with decreased proliferation and impairment in anchorage dependent growth of pancreatic cancer cells. Methods: MiaPaCa and Panc-1 cells were transfected with two different siRNAs targeted to LPAAT-α at 10 nM and 25 nM for 48 hrs and 72 hrs. A non-targeting siRNA was used as a control. The cells were then plated on tissue culture dishes or in soft agar and allowed to proliferate. Proliferation on plastic dishes was measured using Alamar Blue. Colony formation in soft agar was determined by directly counting macroscopic colonies. Results: Transfection of MiaPaCa and Panc-1 cells with siRNA at 25 nM for 72 hours achieved almost 100% inhibition of LPAAT-α protein expression by Western blotting. Under these conditions there was a 50% reduction in proliferation and colony formation. Studies to determine the effects of depleting LPAAT-α on the levels of p-PKC-α, p-MEK, p-4E-BP1 and p-S6Kinase are ongoing and will be presented. Conclusions: Suppression of expression of LPAAT-α protein in pancreatic cancer cell lines reduces proliferation and anchorage independent growth. This contributes to the validation of LPAAT-α as a therapeutic target in pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1854. doi:1538-7445.AM2012-1854
Rapid prototyping of single-photon-sensitive backside-illuminated silicon avalanche photodiode arrays (2019)

We have developed a new approach for rapid die-level hybridization of backside-illuminated silicon avalanche photodiode (APD) arrays to CMOS readout integrated circuits (ROICs). APD arrays are fabricated on a custom silicon-on-insulator (SOI) wafer engineered with a built-in backside contact and passivation layer. The engineered APD substrate structure facilitates uniform APD substrate removal by selective etching at the die level after bump bonding. The new integration process has the following advantages over wafer-level 3D integration: 1) reduced cost per development cycle since a dedicated full-wafer ROIC fabrication is not needed, 2) compatibility with existing ROICs that are in chip-format from previous fabrication runs, and 3) accelerated schedule. The new approach is applied to produce 32×32 100-μm-pitch silicon GmAPD arrays. Electrical performance of the APD arrays show 100% pixel connectivity and excellent yield before and after substrate removal.
Aluminum-lithium alloys -- the next generation (1994)

The advantages of aluminum-lithium (Al-Li) alloys, such as low density and high modulus, have been well documented in the last 15 years, but their impact on the aerospace market has fallen short of initial expectations. However, vacuum refining processes have now been developed at Comalco Aluminium Ltd., Melbourne, Australia, that provide improved mechanical properties. In addition, the patented technology allows higher levels of lithium, which results in higher stiffness and lower densities. For example, alloys with 3.3% lithium and very low amounts of hydrogen and alkali metal impurities demonstrate good mechanical properties. It also exhibits good weldability, as shown in results of varestraint'' testing, which evaluates the tendency to crack during welding. The high purity of these VacLite alloys ensures that grain boundary fracture is minimized, and cleavage fracture is reduced almost to the limit of detectability. Furthermore, advanced vacuum techniques using electron beam melting at 10[sup [minus]5] torr may eventually reduce impurities to a level at which fracture occurs only in a ductile, transgranular manner.
Time Series Analysis via Matrix Estimation. (2018)

We consider the task of interpolating and forecasting a time series in the presence of noise and missing data. As the main contribution of this work, we introduce an algorithm that transforms the observed time series into a matrix, utilizes singular value thresholding to simultaneously recover missing values and de-noise observed entries, and performs linear regression to make predictions. We argue that this method provides meaningful imputation and forecasting for a large class of models: finite sum of harmonics (which approximate stationary processes), non-stationary sublinear trends, Linear Time-Invariant (LTI) systems, and their additive mixtures. In general, our algorithm recovers the hidden state of dynamics based on its noisy observations, like that of a Hidden Markov Model (HMM), provided the dynamics obey the above stated models. We demonstrate on synthetic and real-world datasets that our algorithm outperforms standard software packages not only in the presence of significantly missing data with high levels of noise, but also when the packages are given the underlying model while our algorithm remains oblivious. This is in line with the finite sample analysis for these model classes.
<title>Advanced manufacturability three-mirror telescope</title> (1992)

A new form of the Three Mirror Anastigmat (TMA) optical system is introduced having embedded features that greatly advance state-of-the-art of its manufacturability. A simple fabrication and alignment process is realized by forcing the primary and tertiary mirrors to share a common vertex and all mirrors to share a common axis. The primary-tertiary mirror pair is fabricated on a common substrate with single point diamond turning, eliminating the need for aligning these two elements. Design examples and fabrication data for reimaging and nonimaging telescopes will be presented illustrating benefits of the common vertex construction.
Two-pattern compound photonic crystals with a large complete photonic band gap (2011)

We present a set of two-dimensional aperiodic structures with a large complete photonic band gap (PBG), which are named two-pattern photonic crystals. By superposing two substructures without regard to registration, we designed six new aperiodic PBG structures having a complete PBG larger than 15% for ${\ensuremath{\varepsilon}}_{2}/\phantom{{\ensuremath{\varepsilon}}_{2}{\ensuremath{\varepsilon}}_{1}}\phantom{\rule{0.0pt}{0ex}}{\ensuremath{\varepsilon}}_{1}=11.4$. The rod-honeycomb two-pattern photonic crystal provides the largest complete PBG to date. An aperiodic structure becomes the champion structure with the largest PBG. Surprisingly, the TM and TE gaps of a two-pattern photonic crystal are much less interdependent than the PBGs of conventional photonic crystals proposed before, affording interesting capabilities for us to tune the TM and TE PBGs separately. By altering the respective substructures, optical devices for different polarizations (TE, TM, or both) can readily be designed.
A novel process for methanol synthesis. Progress report, September 1, 1991--November 30, 1991 (1992)

A bench-scale reactor is being used to conduct studies of the conversion of synthesis gas to methanol by a novel process. In previous reports, we provided evidence for a two step reaction in series: the carbonylation of methanol to methyl formate taking place in a non-equilibrium region in the vicinity of the copper chromite surface, and the hydrogenolysis of methyl formate to methanol taking place on the surface of the copper chromite. The synergism between the two catalysts enhances the rate of methanol formation. In this quarter, we tested several copper chromites (with different surface areas and stabilizing agents) on the rate of methanol synthesis. It seems likely that pore diffusion limitations control the hydrogenolysis reaction since the rate of methanol formation is proportional to the square root of the copper chromite surface area. Elemental analyses using Inductively Coupled Plasma analysis and pore size distribution analysis of copper chromite were carried out.
A Vision toward Ultimate Optical Out‐Coupling for Organic Light‐Emitting Diode Displays: 3D Pixel Configuration (2018)

Despite stringent power consumption requirements in many applications, over years organic light-emitting diode (OLED) displays still suffer unsatisfactory energy efficiency due to poor light extraction. Approaches have been reported for OLED light out-coupling, but they in general are not applicable for OLED displays due to difficulties in display image quality and fabrication complexity and compatibility. Thus to date, an effective and feasible light extraction technique that can boost efficiencies and yet keep image quality is still lacking and remains a great challenge. Here, a highly effective and scalable extraction-enhancing OLED display pixel structure is proposed based on embedding the OLED inside a three-dimensional reflective concave structure covered with a patterned high-index filler. It can couple as much internal emission as possible into the filler region and then redirect otherwise confined light for out-coupling. Comprehensive multi-scale optical simulation validates that ultimately high light extraction efficiency approaching ≈80% and excellent viewing characteristics are simultaneously achievable with optimized structures using highly transparent top electrodes. This scheme is scalable and wavelength insensitive, and generally applicable to all red, green, and blue pixels in high-resolution full-color displays. Results of this work are believed to shed light on the development of future generations of advanced OLED displays.
A cardioactive factor in human plasma with positive inotropic and positive chronotropic activities (1980)

A cardioactive factor with a molecular weight of about 100,000 and that exhibits positive inotropic and positive chronotropic activity on isolated guinea pig atria has been found in human plasma. The positive inotropic activity is less stable than the positive chronotropic activity. The two activities move together in cation- and anion-exchange chromatography, gelfiltration chromatography, and polyethylene glycol precipitation. They may be associated with a single large polypeptide or with different subunits of a complex protein.
A body powered prehensor with variable mechanical advantage (1994)

The purpose of this research was to improve body powered, voluntary closing (VC) prosthetic prehension. A prototype prehensor with variable mechanical advantage was fabricated and tested. The device operates at low mechanical advantage during sizing of an object to reduce cable excursion requirements. It shifts to high mechanical advantage during gripping to allow high prehensile forces to be generated with reduced cable tension. The prototype provides a mechanical advantage of 2.4, nearly five times that of conventional VC devices. The prototype also acts as a holding assist; after grip forces are applied, they can be maintained with a cable tension of only 3 lb (13.34N). Field testing indicated that the device performs well in many tasks. The mechanism allows greater range of motion while an object is grasped than standard voluntary closing prehensors. However, the device performed poorly in grasping very compliant objects. To address this problem, a switch has been incorporated into the prototype to allow it to be used in a free-wheel mode.
<title>Measurements of the posterior structures of the human eye in vivo by partial-coherence interferometry using diffractive optics</title> (1997)

In the past ten years, the dual beam version of partial coherence interferometry has been developed for measuring intraocular distances in vivo with a precision on the order of 0.3 to 3 micrometer. This technique has now been further improved by using diffractive optics. A special diffractive optical element focuses part of the laser beam on the vertex of the cornea and lets the other collimated parallel part of the beam pass through. The beams remitted from the eye will thereby be converted into parallel beams. The light power oscillations in the corresponding interferograms are much stronger than those of the narrow interference fringes obtained without that technique what significantly improves the signal to noise ratio. This makes it possible to clearly differentiate signals from different fundus layers. High precision in vivo fundus measurements have been performed at various positions on the human retina in order to obtain fundus profiles. These measurements have been synthesized to tomographic images of the human eye fundus. In order to localize the exact measurement point on the retina simultaneously to the fundus scans, a fundus camera has been implemented into the partial coherence interferometry system that allows a clear identification of the individual A-scan positions.
Hopping Pilots for Estimation of Frequency-Offset and Multiantenna Channels in MIMO-OFDM (2005)

We design pilot-symbol-assisted modulation for carrier frequency offset (CFO) and channel estimation in orthogonal frequency-division multiplexing transmissions over multi-input multi-output frequency-selective fading channels. The CFO and channel-estimation tasks rely on null-subcarrier and nonzero pilot symbols that we insert and hop from block to block. Because we separate CFO and channel estimation from symbol detection, the novel training patterns lead to further decoupled CFO and channel estimators. The performance of our algorithms is investigated analytically, and then compared with an existing approach by simulations.
Cirrhotic cardiomyopathy: an endocannabinoid connection? (2005)

British Journal of Pharmacology (2005) 146 , 313–314. doi: 10.1038/sj.bjp.0706332