gebhart/patrepeval huggingface dataset:
New high-efficiency quasi-continuous operation of a KrF(<i>B</i>→<i>X</i>) excimer lamp excited by microwave discharge (1989)

A quasi-continuous KrF(B→X) fluorescence of &gt;8 ms pulse duration with 100 Hz operation frequency was observed in a microwave discharge-pumped KrF lamp. The average KrF fluorescence power was 53 W, obtained with an intrinsic efficiency of 8.3% with a 678 W average microwave power deposition. We also obtained a peak KrF fluorescence power of 120 W with a power efficiency of 12.1%.
Neuronal nicotinic receptors: from protein structure to function (2001)

Neuronal nicotinic acetylcholine receptors are a prototype of ligand-gated channels that mediate transmission in the central and peripheral nervous system. Structure-function studies performed at the amino acid level are now unraveling the determinant residues either for the properties of the ligand-binding domain or the ionic pore. In this work we review, in the light of the latest finding, the structure-function relationship of these receptors and their implication in neurological diseases.
Performance of a panel of maternal serum markers in predicting preeclampsia at 11–15 weeks' gestation (2007)

This analysis revealed that maternal serum markers assessed at the first and second trimester of pregnancy in asymptomatic patients can improve the early detection of cases at higher risk of developing PE.
Effect of a wideband heteroepitaxial emitter on dynamics of turn-off switching of high-voltage power GaAs p-i-n diodes (2016)

The possibility of improving the dynamic characteristics of turn-off switching of high-voltage power GaAs p-i-n diode by applying a heteroepitaxial AlGaAs emitter is investigated in this work. Using a wideband AlGaAs n+-emitter in manufacturing of power GaAs p-i-n diodes allows to vary the coefficient K value which characterizes the recovery softness of diode blocking properties when switching off in the range of 0.1 to 2 or more. The diodes with blocking voltage of up to 700 V, the reverse recovery time of about 40 ns and K > 1 were manufactured.
Women in technology (2013)

The low numbers of female students in computing and computer science courses is still of concern. Initiatives to bring together women in technology to share their experiences, is an important aspect of increasing the numbers of female students entering the computing profession. A very successful celebration of Women in Technology was recently held in Australasia based on a tried and true US model. This model was adapted for the region and added to, other countries will be able to take the model and use it in their own environments and cultures. This poster will describe the recent event and give suggestions and models for other regions and countries to be able to replicate it.
Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit (2008)

N-Methyl-D-aspartate receptors (NMDARs) mediate certain forms of synaptic plasticity and learning. We used a touchscreen system to assess NR2A subunit knockout mice (KO) for (1) pairwise visual discrimination and reversal learning and (2) acquisition and extinction of an instrumental response requiring no pairwise discrimination. NR2A KO mice exhibited significantly retarded discrimination learning. Performance on reversal was impaired in NR2A KO mice during the learning phase of the task; with no evidence of heightened perseverative responses. Acquisition and extinction of an instrumental behavior requiring no pairwise discrimination was normal in NR2A KO mice. The present findings demonstrate a significant and selective deficit in discrimination learning following loss of NR2A.
Simultaneous transmission line parameter and PMU measurement calibration (2015)

Transmission line parameter modeling and PMU measurement calibration are important research topics in power system engineering. State estimation is widely used to estimate voltage with assumption of “accurate” system parameters. Various methods have also been proposed to estimate line parameters based on PMU measurements. However, neither system parameters nor system measurements are reliable enough to be used to estimate each other separately. To solve this problem, this paper proposes a novel method that can simultaneously estimate line parameters as well as measurements. This method requires PMUs installed at both terminals of the transmission lines. It also requires only one bus with accurate voltage measurements and accurate current measurements. These accurate measurements can be achieved by pre-calibrated PMU receiving signals from pre-calibrated current transformers and voltage transformers. Accurate line parameters and measurements estimated by this method can be used to improve state estimation, power system monitoring and protection and several other applications.
Novel approach to quantitative polymerase chain reaction using real‐time detection: Application to the detection of gene amplification in breast cancer (1998)

Gene amplification is a common event in the progression of human cancers, and amplified oncogenes have been shown to have diagnostic, prognostic and therapeutic relevance. A kinetic quantitative polymerase-chain-reaction (PCR) method, based on fluorescent TaqMan methodology and a new instrument (ABI Prism 7700 Sequence Detection System) capable of measuring fluorescence in real-time, was used to quantify gene amplification in tumor DNA. Reactions are characterized by the point during cycling when PCR amplification is still in the exponential phase, rather than the amount of PCR product accumulated after a fixed number of cycles. None of the reaction components is limited during the exponential phase, meaning that values are highly reproducible in reactions starting with the same copy number. This greatly improves the precision of DNA quantification. Moreover, real-time PCR does not require post-PCR sample handling, thereby preventing potential PCR-product carry-over contamination; it possesses a wide dynamic range of quantification and results in much faster and higher sample throughput. The real-time PCR method, was used to develop and validate a simple and rapid assay for the detection and quantification of the 3 most frequently amplified genes (myc, ccnd1 and erbB2) in breast tumors. Extra copies of myc, ccnd1 and erbB2 were observed in 10, 23 and 15%, respectively, of 108 breast-tumor DNA; the largest observed numbers of gene copies were 4.6, 18.6 and 15.1, respectively. These results correlated well with those of Southern blotting. The use of this new semi-automated technique will make molecular analysis of human cancers simpler and more reliable, and should find broad applications in clinical and research settings. Int. J. Cancer 78:661–666, 1998. © 1998 Wiley-Liss, Inc.
Handheld instrument to detect defects in conductive plates with a planar probe (2011)

This paper presents a novel low-cost handheld instrument to detect cracks and other defects in a plate of conductive material. The instrument includes a planar eddy-current probe having a giant magnetoresistor (GMR) based sensor, a mouse pointing device that acts as the positioner, a dsPIC that controls the measurement process and that possesses also signal processing capabilities to enhance the accuracy of the system and all the electronic circuitry (power supplies, signal amplification, current generation, analog to signal conversion) necessary to carry out the defect detection. The visualization of the defect can be depicted in real-time on a LCD display or transmitted to a PC. The metrological performance and the effective cost make this handheld device well suited for several applications such as cracks detection at subsurface depths.
Polymerization reaction with diphenylphosphoryl azide. Preparation of poly(α‐amino acid)s by direct polycondensation of α‐amino acids (1991)

Abstract Polypeptides can be prepared by stirring an amino acid solution in the presence of diphenylphosphoryl azide (DPPA) and an adequate tertiary amine. Generally, 1,3 mol of DPPA and 2,3 mol of triethylamine per mol of amino acid gave the best result. Polymerization of various amino acids (Gly, Ala, Leu, Phe, Met, Glu(OBzl), Glu(OMe), Cys(Bzl), Ser(Bzl), His(Bzl), Lys(Z), Arg(Tos), Arg(NO 2 ), Arg(Mts), etc.; cf. Tab. 2) in dimethyl sulfoxide, N , N ‐dimethylformamide, 1,4‐dioxane, pyridine, etc. gave the corresponding polypeptides with molecular weights as estimated from their intrinsic viscosities between 3 000 and 16 000, in reasonable yields. The purity of the resulting polypeptides was confirmed by IR, elemental analysis and optical rotation measurements of their acid total hydrolysates.
Micronized 17β-Estradiol for Oral Estrogen Therapy in Menopausal Women (1975)

Micronized 17beta-estradiol (E2) was used as oral replacement therapy in 369 patients with estrogen deficiency and related menopausal symptoms. Over 95 percent of 319 patients evaluable for efficacy gained satisfactory relief of their symptoms from cyclic (on 21 days/off 7 days) E2 therapy. Approximately 77 percent required no adjustment of their initial daily dose, viz, 1 mg (5 or less hot flushes per day) or 2 mg (6 or more flushes daily). In addition, 80 percent (58/72) of the patents who did not obtain adequate control from their starting dose were successfully titrated, either upward to a maximum of 4 mg/day or downward for maintenance. Overall, a higher percentage of patients were treated successfully with 2 mg daily (209/319; 66 percent) than with 1 mg/day (22 percent). About 8 percent of the patients required 3 or 4 mg daily, while 4 percent failed to derive adequate benefit from micronized E2. Oral E2 therapy was well tolerated; hence, the attrition rate due to side effects or lack of control was only 6 percent (22/369). Moreover, all laboratory fingings were within normal limits, even in patients treated with E2 for over 12 months. Coincidental endometrial changes were found in 9 patients, all of whom had received long-term (9 months-3 years) estrogen therapy prior to entering this study. Thus, the stste of the endometrium should be determined before any estrogens are given for the monopause. It is concluded that micronized E2 is highly efficacious, well accepted, and safe for oral estrogen-replacement therapy in menopausal women.
Deploying Sensors for Gravity Measurement in a Body-Area Inertial Sensor Network (2012)

This paper deals with human posture tracking by deploying accelerometers on a human body. One fundamental issue in such scenarios is how to calculate the gravity. This is very challenging especially when the human body parts keep on moving. Fortunately, it is likely that there is a point of the body that touches the ground in most cases. This allows sensors to collaboratively calculate the gravity vector. Assuming multiple accelerometers being deployed on a rigid part of a human body, a recent work proposes a data fusion method to estimate the gravity vector on that rigid part. However, finding the optimal deployment of sensors that minimizes the estimation error of the gravity vector is not addressed. In this paper, we formulate the deployment optimization problem and propose two heuristics, called Metropolis-based method and largest-inter-distance-based method. Simulation and real experimental results show that our schemes are quite effective in finding near-optimal solutions for a variety of rigid body geometries.
A robust duplex Cu/PDMS-coated mesh with superhydrophobic surface for applications in cleaning of spilled oil (2017)

In this study, we created a robust nanostructure coated on the surface of a mesh <italic>via</italic> the electrodeposition and chemical modification to enhance the mechanical durability of the mesh surface with superhydrophobic performance.
Recommender Systems as Multistakeholder Environments (2017)

Recommender systems are typically evaluated on their ability to provide items that satisfy the needs and interests of the end user. However, in many real world applications, users are not the only stakeholders involved. There may be a variety of individuals or organizations that benefit in different ways from the delivery of recommendations. In this paper, we re-define the recommender system as a multistakeholder environment in which different stakeholders are served by delivering recommendations, and we suggest a utility-based approach to evaluating recommendations in such an environment that is capable of distinguishing among the distributions of utility delivered to different stakeholders.
Immunofunctional properties of a yolk sac epithelial cell line expressing two proteins gp280 and gp330 of the intermicrovillar area of proximal tubule cells: inhibition of endocytosis by the specific antibodies. (1995)

The apical domain of epithelial cells lining the proximal tubule and the yolk sac is characterized by the development of extensive microvilli which limit intermicrovillar spaces backed on their cytoplasmic aspect by a coat of clathrin. These membrane areas which give rise to endocytic vesicles are characterized by the expression on their outer aspect of two high molecular weight glycoproteins: gp330 and gp280. In this study we report on an epithelial cell line, BN/MSV, derived from a yolk sac carcinoma which expresses these two glycoproteins. By indirect immunofluorescence, gp330 and gp280 were detectable on the cell surface and after permeabilization in intracytoplasmic vesicles. At the ultrastructural level they were concentrated in clathrin-coated membrane areas and although gp280 could also be detected in non-coated areas. The two proteins were synthesized independently in the form of high molecular weight polymers by biosynthetically labeled BN/MSV cells. Both were released in the supernatant, but, in spite of previously reported similarities by peptide mapping, only gp330 coprecipitated with a 45 kDa protein comigrating with the alpha 2-macroglobulin receptor-associated protein (MRAP). Culture of the cells in the presence of antibodies to gp280 and to a lesser extent of antibodies to gp330 inhibited the internalization of [14C]sucrose and peroxidase. When followed intracellularly at the ultrastructural level, the compartments containing peroxidase in the presence of anti-gp280 or gp330 antibodies were morphologically distinct from those observed under control conditions: vesicles were of smaller size and irregular shape and accumulation in lysosomes was delayed.(ABSTRACT TRUNCATED AT 250 WORDS)
Ocean Disposal and Construction with Stabilized Coal Waste Blocks (1983)

A multidisciplinary team of scientists at SUNY, Stony Brook is assessing the feasibility of using blocks of waste material from coal fired power plants for underwater construction, including building artificial fishing reefs. Experiments over the past five years, both in the laboratory and in the sea, suggest that coal waste blocks are environmentally acceptable in the ocean. On September 12, 1980, a 500-ton reef was constructed in the Atlantic, consisting of 15,000 solid blocks of stabilized FGD sludge and fly ash from coal burning power plants. The blocks were fabricated in collaboration with Conversion Systems, Inc. (Horsham, Pennsylvania) at a commercial concrete block plant. In preparation for block fabrication, a combination of different coal waste mixes, stabilization additives, and curing procedures were screened to develop candidate mix designs. Experiments were conducted at research fsei1ities of the Besser Company in Alpena, Michigan to develop methods of successfully forming coal waste blocks with block making machines. The demonstration disposal reef is being monitored to assess environmental impacts which may occur and their relation to structural integrity and chemical properties of the coal waste blocks. Blocks are tested ultrasonically in the sea and also returned to the laboratory for compressive strength measurements. After almost two years in the sea, gradual increases in strength have been documented. The progress of biological colonization is also monitored and compared with existing reefs in the area. The fish, benthos, and encrusting organisms are sampled and analyzed for uptake of block components. Data from fish tagging surveys have indicated significant increases in the resident populations of various species of fish and lobster.
GO!Caronas: Fostering ridesharing with online social network, candidates clustering and ride matching (2016)

The larger amount of motor vehicles produces many problems to cities around the world as poor urban mobility, environment concerns and people's health. The encouragement to use alternative means of transport, such as bicycles or subways is one of the steps to solve the problem. Another way is to encouraging the optimal usage of private automobiles. In Brazil, for instance, several studies show an underused space in cars and great potential for the use of carpooling and car sharing. Unfortunately, there is not such a unified technological mean to properly support these alternatives. In this paper we extend a carpooling social network with ridematching functionality in order to enable real-time ridematching. Furthermore, we implemented a functionality of group formation to encourage people to offer or get regular rides. We show that there is a favorable context to share rides between users. We describe the architecture of the system and implementation details. We present results about system's profiling and present a comparison of results related with acceptability of getting or offering ride between the years 2013 and 2015.
Ras Farnesyltransferase:  A New Therapeutic Target (1997)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTRas Farnesyltransferase: A New Therapeutic TargetDaniele M. LeonardView Author Information Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, Michigan 48105 Cite this: J. Med. Chem. 1997, 40, 19, 2971–2990Publication Date (Web):September 12, 1997Publication History Received3 April 1997Published online12 September 1997Published inissue 1 September 1997https://pubs.acs.org/doi/10.1021/jm970226lhttps://doi.org/10.1021/jm970226lreview-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views829Altmetric-Citations201LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cells,Inhibitors,Monomers,Peptides and proteins,Tumors Get e-Alerts
P-channel, ion implanted, GaAsSb/InAlAs HIGFETs on InP for digital and microwave applications (2002)

We report the first device results of ion implanted, recessed gate, p-channel GaAsSb/InAlAs HIGFETs grown lattice matched to InP with tremendous potential for use in a complementary technology on III-V substrates. The InAlAs/GaAsSb heterostructure possesses excellent hole confinement, and this is coupled to a p-channel device process which employs ion implanted contacts and a recessed gate. This implies the GaAsSb/InAlAs p-channel HIGFET has advantages in both digital and microwave design. Close examination of the GaAsSb/InAlAs heterostructure material during process development, provides an important feedback loop which resulted improved p-channel device characteristics. Microstructural evaluation of the ohmic contacts and its effect on their electrical stability are presented. Direct current characteristics and unique photoelectric characterization results on the fabricated p-channel HIGFETs are provided. Comments on maturing GaAsSb/InAlAs HIGFETs into a self-aligned gate, submicron, complementary technology for integrated circuit applications are outlined.
Single crystal thin films of conductive oxides SrRuO<sub>3</sub> and ferroelectric heterostructures (1998)

Abstract We have grown epitaxial thin films of the conductive oxide SrRuO3 with well controlled surface morphology and domain structure using vicinal (001) SrTiO3 substrates. Scanning tunneling microscopy and x-ray diffraction show that the SrRuO3 thin films on miscut (001) SrTiO3 substrates with miscut angle > 2° grow by step flow in one direction leading to single crystal films. In contrast, the SrRuO3 thin films on exact (001) SrTiO3 substrates grow by two dimensional nucleation resulting in a two domain in-plane structure. The single crystal thin films have been used as electrodes for the growth of epitaxial ferroelectric PbTiO3 and PZT layers. The PbTiO3/SrRuO3 and PZT/SrRuO3 heterostructures have high crystalline quality, coherent interfaces and a cube-on-cube epitaxial growth with respect to the substrate. These epitaxial heterostructures have superior fatigue characteristics and look promising for the fabrication of integrated single crystal ferroelectric devices.
Submicron Electrode Gaps Fabricated by Gold Electrodeposition at Interdigitated Electrodes (2014)

Electrodes with submicron gaps are desired for achieving high amplication redoxcycling sensors. In this contribution we report the use of electrodeposition of gold in order todecrease the inter-electrode spacing at interdigitated electrodes. Using this method submicronspacings can be obtained without expensive techniques such as e-beam lithography or focusedion beam milling. Initially, gold interdigitated electrodes with a nger spacing of 2.5 m wererealized by lift-o processing. Using a commercial gold sulphite bath (ECF64D) and 100 mscurrent pulses of -1.78 A, these gold electrodes were plated with an additional gold layer. Asa result, the inter- electrode spacing, as measured using atomic force microscopy and conven-tional microscopy, was reduced to 0.6 m. The achieved gap spacing is limited by electrodeimperfections resulting from the lift-o process. At these imperfections the electrodes becomeshorted. Additional experiments with wet etched electrodes are expected to yield smaller gapspacings
Community management of lactational mastitis and/or breast abscess: a retrospective audit. (2017)

Lactational mastitis has an incidence of around 10 per cent in postpartum women, with breast abscess complicating some of these.The key principles of treatment include: supportive counselling, warm or cold compresses, effective milk removal, oral antibiotic therapy and symptomatic treatment. Patients can be managed in the community setting; however many present to hospital. The aim of this research was to establish which areas of clinical practice can be improved to reduce hospital admission rates. Sequential cases of lactation mastitis or breast abscess admitted to hospital over two years were reviewed, and it was found that the majority of patients attending the emergency department for management self-presented. There were low rates of utilisation of available community resources. There was poor patient knowledge of the natural history and simple management strategies for the condition. Midwives can play a vital role in educating new mothers and providing advice and support for non-pharmacological therapies.