gebhart/patrepeval huggingface dataset:
WR-2721 protects against the hematologic toxicity of cyclophosphamide: a controlled phase II trial. (1986)

WR-2721 S-2-(3-aminopropylamino) ethyl phosphorothioic acid, is an organic thiophosphate compound that in the animal model selectively protects against the hematologic toxicity of cyclophosphamide by factors of 1.5 to 2.0. Preliminary data from our controlled phase I trial of WR-2721 and cyclophosphamide suggested that WR-2721 protected against cyclophosphamide-induced granulocytopenia. Since variable drug doses and infusion rates were used in these early studies, we initiated a controlled phase II trial using constant drug doses to establish more precisely WR-2721's level of protection. Initially, 21 patients received 1,500 mg/m2 of cyclophosphamide alone and were retreated 4 weeks later after hematologic recovery was complete with 740 mg/m2 of WR-2721 before the same dose of cyclophosphamide. With WR-2721 pretreatment, 19 of 21 (90%) patients had improved WBC and granulocyte counts. The mean WBC increased from 1,760/mL with cyclophosphamide alone to 2,500/mL with WR-2721 pretreatment (P less than .0005). The mean granulocyte count increased from 541/mL on cyclophosphamide to 1,247/mL with WR-2721 and cyclophosphamide (P less than .0005). Following cyclophosphamide administration alone, neutropenic fevers developed in three patients. No patient experienced a febrile episode following WR-2721 and cyclophosphamide administration. Platelet nadirs below 100,000/mL were only noted in two patients treated with cyclophosphamide alone. Objective partial responses were observed in four of 19 (21%) patients with measurable or evaluable disease. These data suggest that WR-2721 provides significant protection against cyclophosphamide-induced hematologic toxicity.
Leishmanicidal potential of N-substituted morpholine derivatives: Synthesis and structure–activity relationships (2009)

A series of N-substituted morpholines 2-20 was synthesised by reacting various acid chlorides and alkyl halides with morpholine (1). All of the synthesised compounds 2-20 were screened for their leishmanicidal effects using amphotericin B (IC(50) = 0.24 microg L(-1)) and pentamidine (IC(50) = 2.56 microg mL(-1)) as standards and a structure-activity relationship (SAR) study was established. The compounds 2 (IC(50) = 48 microg mL(-1)), 3 (IC(50) = 30.0 microg mL(-1)), 10 (IC(50) = 41.0 microg mL(-1)), 15 (IC(50) = 33.0 microg mL(-1)), 16 (IC(50) = 35.0 microg mL(-1)) and 20 (IC(50) = 47.0 microg mL(-1)) showed weak leishmanicidal activities.
Task scheduling in cluster computing environment (2015)

Cluster computing is an emergent platform for high performance computing to minimize work completion time. Cluster computing is group of among similar tasks to reduce communication cost and minimize application finish time. Scheduling techniques such as random list generation, duplication and dynamic scheduling used to identify and schedule similar tasks and independent tasks to improve resource utilization and minimize makespan. Numbers scheduling algorithm already proposed on cluster computing for high performance. This paper reviews of scheduling algorithms and discussion about scheduling techniques on cluster computing for utilization and high performance. The paper proposed swarm technique for task scheduling on clusters to improve utilization and produce better results.
A 2.5 V 256-level non-volatile analog storage device using EEPROM technology (2002)

This integrated circuit stores 256 analog voltage levels in high density, non-volatile memory with /spl sim/7.5m V resolution per level. By contrast, the multilevel storage capacity of a typical digital non-volatile memory is 4-level per cell. The integrated circuit operates over a voltage range of 2.5 V to 5.5 V. Previous analog storage implementation use a 5.0 V supply for /spl sim/12 mV equivalent resolution per level in a 128 k EEPROM.
Effect of seed coating protectants on iron deficiency chlorosis and sorghum plant growth (1992)

Abstract Chemical coatings on seed are commonly used in the grain sorghum seed industry to protect plants against herbicide damage and to inoculate young plants against certain disease. In this study, grain sorghum grown from seed safened with CGA‐92194 ([(l,3‐dioxolo‐2‐yl‐methoxy)‐imino] benzene‐acetonitrile} against injury from the herbicide, metolachlor, was studied for seedling vigor, seedling emergence, plant growth, and Fe‐deficiency chlorosis. Other seed was additionally treated with a systemic fungicide [(Metalaxyl:N‐(2,6‐dimethylphenyl)‐N‐(methoxyacetyl) alaminemethyl ester)] for control of systemic downy mildew and diseases caused by soilborne Phythium and Phytophthora spp. The experiment was conducted on Fe‐sufficient and Fe‐deficient soils. CGA‐92194 safened seed showed a slight reduction in stand on Goliad sandy loam soils (Fe‐sufficient), while the addition of the fungicide together with the herbicide safener reduced plant emergence by 39%. Sorghum emergence was generally not affected by seed treatment on the Monteola clay (Fe‐deficient). Soil applications of Fe‐EDDHA appeared to ameliorate the deleterious effects of seed treatment on the coarse textured soil. CCA‐92194 reduced early plant growth approximately some 30% on the coarse textured soil but had no effect on the clay. Fungicide and CCA‐92194 treated seed resulted in 70% and 24% reduction in seedling growth for the sandy and clay soils, respectively. A slight increase in Fe‐deficiency chlorosis was noted on sorghum grown from coated seed on the Monteola soil. Iron treatment on the sandy soil appeared to reduce suppression of growth due to the seed treatment.
Carbon dioxide electrolysis and carbon deposition in alkaline-earth-carbonate-included molten salts electrolyzer (2018)

Alkaline-earth-carbonate-included molten salts sustain continuous CO<sub>2</sub> capture and electrochemical conversion.
Circadian Activity of <I>Lygus lineolaris</I> (Hemiptera: Miridae) and Effectiveness of Sampling Techniques in Strawberry Fields (2000)

Mobility and distribution of adult tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), was studied on a day-neutral strawberry cultivar ('Selva') in 1991 and 1992 at L'Acadie, Quebec, Canada. On cage-covered plants, individuals were located mainly on reproductive parts. Study of the flight activity with sticky posts revealed that most captures were obtained < 1 m from ground level and that the time of the day at which the maximum counts occur varied among seasons. Three pest-sampling methods (white sticky trap, tapping of flower clusters, and D-Vac) were evaluated over continuous 24-h periods. Maximum captures of adults with white sticky traps were made at midday (1000-1400 hours), whereas the two other methods proved more effective at the beginning (0600-0800 hours) or the end of the day (2000-2200 hours) or during night time. For nymphs, maximum catches were obtained during the day with tapping and D-Vac; white sticky traps were ineffective. Because the D-Vac captures individuals present on all parts of the plant, these counts were used to monitor the effectiveness of the two other sampling techniques. The data suggest that tapping flower clusters throughout the day is a very effective sampling method to estimate nymphal tarnished plant bug populations in strawberries. However, sampling of populations with a high proportion of adults should take into account the bias caused by their flight activity, and sampling should be conducted early in the morning or at the end of the day.
Decision making on the flight deck (1997)

Decision making research has traditionally focused on normative models of the decision process, using controlled environments to study decision making. However, this does not translate very well to operating environments such as the flight deck, and therefore the models do not account for many of the characteristics of real decision making. Naturalistic decision making (NDM) research studies decision making in operational settings with experienced operators and so it is suited to the civil flight deck. However, there are certain aspects of pilot decision making which do not seem to be covered by existing NDM models and theories. This paper outlines an integrated decision model (IDM) which draws on other theories but is more descriptive of pilot behaviour and applicable to supporting pilot decisions. This IDM highlights areas of weakness in decision making and the types of errors that can be made. The model may also be used to point to areas where these errors may be detected, and where decision support may intervene to correct them.
[SARS: a new emergency in the world health]. (2003)

The Severe Acute Respiratory Syndrome (SARS) is a new life-threatening respiratory disease which has its origins in Guangdong province, China, where the earliest known cases were identified in November 2002. Since then, probable cases of SARS have been reported in 30 countries and the current cumulative number of cases is 8,240 with 745 deaths and a global fatality rate of 9%. The most frequently involved areas include China, Hong Kong, Singapore, Canada, Vietnam and Philippines. Most cases of SARS to date have occurred in young adults and this disease appears to spread most commonly by close person-to-person contact, involving exposure to infectious droplets and body fluids. This transmission pattern generally involves household members, health care workers and international travellers, while a large and sudden cluster of almost simultaneous cases in an housing estate of Hong Kong has raised the possibility of transmission from an environmental source. The most common presenting symptoms are fever, malaise, non-productive cough and dyspnea, associated with pulmonary interstitial infiltrates on chest radiography. A novel coronavirus is associated with this outbreak, and the laboratory evidences indicate that this virus has an etiologic role in SARS, but the role of other concurrent viral agents (such as metapneumovirus) identified in these patients requires further investigation.
Inhibition of the Complement Activation by an AdrenalAndrogen, Dehydroepiandrosterone (1984)

The effect of dehydroepiandrosterone (DEA), an adrenal androgen successfully used for preventing attacks in hereditary angioneurotic edema (HANE) patients was studied on the activation of classical and alternative complement pathway. The steroid inhibited both the spontaneous and immune activation of the classical complement pathway (CP), the former effect, however, was found to be more marked than the latter one. DEA exerted its inhibiting effect most probably by interfering with the internal activation of C1. Because DEA rendered HANE patients symptom free but induced only a slight increase in their serum C1-INH level, our present findings suggest that inhibition of CP activation may have a significance in the therapeutic effect of DEA and possibly of other androgens as well.
Density-functional calculation of the electronic structure and equilibrium geometry of iron pyrite (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">FeS</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>) (1994)

The electronic structure and equilibrium geometry of the pyrite form of ${\mathrm{FeS}}_{2}$ was studied using self-consistent density-functional theory comparing the local-density-approximation (LDA) and the generalized-gradient-approximation (GGA) forms of the exchange-correlation functional. The calculated contour map of the electron-deformation density is consistent with analysis of high-resolution x-ray-diffraction data, showing excess charge in nonbonding d states on the Fe sites. At the experimentally measured geometry, the cohesive energy is calculated to be 16.7 eV/${\mathrm{FeS}}_{2}$ and 9.4 eV/${\mathrm{FeS}}_{2}$ for the LDA and GGA forms, respectively; the GGA result comparing well with the experimental value of 10.7 eV/${\mathrm{FeS}}_{2}$. Optimizing the cohesive energy as a function of geometry, both the LDA and GGA calculations find the optimal structure to be expanded relative to the experimental geometry with the lattice constant expanded by 1% and the S-S bond length expanded by 6%, corresponding to a 0.1-eV increase in the cohesive energy for each ${\mathrm{FeS}}_{2}$ unit. Similar results were obtained for ${\mathrm{RuS}}_{2}$.
Differentiating Molecular Risk Assessments for Prostate Cancer. (2018)

It is critically important to the evolving goals of prostate biopsy to find clinically significant cancer with lethal potential and avoid detection of indolent disease. Better tests and markers are required for improved detection of clinically significant prostate cancer and avoidance of biopsies in men with indolent disease. Currently, there are myriad alternative prostate cancer risk-assessment tests available derived from serum and urine that are designed to improve the specificity for detection of "significant" prostate cancer. Herein we discuss these tests and their clinical implications.
Synthesis of novel chiral β-amino alcohols and diamino alcohols from products of Ugi 3-component reaction (2006)

Novel chiral -amino alcohols and diamino alcohols, which are useful in catalytic asymmetric syntheses, were prepared from the products of Ugi 3-component reaction.
Fault analysis: optical performance investigation of fiber connections with imperfect physical contact (2011)

We investigated the insertion and return losses of optical fiber connections with various air-filled gaps. Such gaps might occur when a fiber connection using physical contact unexpectedly fails, resulting in imperfect physical contact. The optical performance of these fiber connections depends on wavelength and gap size. We revealed that the measured optical performance of fiber connections with an imperfect physical contact, i.e., with an air-filled gap, might deteriorate to ~18 dB for insertion loss and 9.4 dB for return loss at worst.
Retinoic Acid Receptor β Controls Development of Striatonigral Projection Neurons through FGF-Dependent and Meis1-Dependent Mechanisms (2015)

The mammalian striatum controls sensorimotor and psychoaffective functions through coordinated activities of its two striatonigral and striatopallidal output pathways. Here we show that retinoic acid receptor β (RARβ) controls development of a subpopulation of GABAergic, Gad65-positive striatonigral projection neurons. In Rarb(-/-) knock-out mice, concomitant reduction of Gad65, dopamine receptor D1 (Drd1), and substance P expression at different phases of prenatal development was associated with reduced number of Drd1-positive cells at birth, in contrast to normal numbers of striatopallidal projection neurons expressing dopamine receptor D2. Fate mapping using BrdU pulse-chase experiments revealed that such deficits may originate from compromised proliferation of late-born striosomal neurons and lead to decreased number of Drd1-positive cells retaining BrdU in postnatal day (P) 0 Rarb(-/-) striatum. Reduced expression of Fgf3 in the subventricular zone of the lateral ganglionic eminence (LGE) at embryonic day 13.5 may underlie such deficits by inducing premature differentiation of neuronal progenitors, as illustrated by reduced expression of the proneural gene Ascl1 (Mash1) and increased expression of Meis1, a marker of postmitotic LGE neurons. In agreement with a critical role of FGF3 in this control, reduced number of Ascl1-expressing neural progenitors, and a concomitant increase of Meis1-expressing cells, were observed in primary cell cultures of Rarb(-/-) LGE. This defect was normalized by addition of fibroblast growth factor (FGF). Such data point to role of Meis1 in striatal development, also supported by reduced neuronal differentiation in the LGE of Meis1(-/-) embryos. Our data unveil a novel mechanism of development of striatonigral projection neurons involving retinoic acid and FGF, two signals required for positioning the boundaries of Meis1-expressing cells.
Fast Positive Deconvolution of Hyperspectral Images (2012)

In this brief, we provide an efficient scheme for performing deconvolution of large hyperspectral images under a positivity constraint, while accounting for spatial and spectral smoothness of the data.
Preliminary Evaluation of Medetomidine/Ketamine Combinations for Immobilization and Reversal with Atipamezole in Three Tortoise Species (1998)

ABSTRACT Twenty immobilizations, for various minor clinical procedures, were performed on 12 adult and sub-adult leopard, Geochelone pardalis , yellow foot, Geochelone denticulata , and Aldabra, Aldabrachelys gigantea , tortoises with a combination of medetomidine and ketamine. An intravenous dose rate of 100 μg/kg medetomidine for leopard and yellow foot tortoises and 25 - 80 μg/kg for Aldabra tortoises resulted in induction times (time from drug injection until the head could be pulled out and the mouth opened) that ranged between 4 and 16 minutes (median 10) and 15 - 45 minutes (45) respectively. Recovery times (time from drug injection until the tortoise was able to withdraw its head with strength) using intravenous atipamezole at a dose rate of 400 μg/kg for leopard and yellow foot and 100 - 380 μg/kg for Aldabra tortoises ranged between 2 and 30 minutes (5) and 5 - 15 minutes (5) respectively. Most (90%) of leopard and yellow foot tortoises experienced a drop in heart rate from baseline following medetomidine/ketamine administration, however no clinical complications were noted. Two leopard tortoises vomited post intravenous injection of atipamezole. One Aldabra tortoise exhibited penile prolapse following intravenous injection of medetomidine/ketamine and one yellow foot and three Aldabra tortoises exhibited a transient bilateral hindlimb paralysis even after reversal with atipamezole.
Effect of low-intensity direct current on the healing of chronic wounds: a literature review (2008)

Few studies have assessed the effectiveness of electrical stimulation on chronic wounds. Nevertheless, the evidence suggests it is a potentially useful, accessible and cheap therapy, which might play a valuable role in everyday practice.
Vibration resistance, short coherence length operation, and mode-locked pumping in passive phase conjugate mirrors (1985)

Because the ring and semilinear passive phase conjugate mirrors use dynamic transmission holograms, they are insensitive to vibration and may be pumped with light of short coherence length or with picosecond mode-locked laser light. Experimental demonstrations of these modes of operation are described.
Multiplexed variation scanning for 1,000 amplicons in hundreds of patients using mismatch repair detection (MRD) on tag arrays (2005)

Identification of the genetic basis of common disease may require comprehensive sequence analysis of coding regions and regulatory elements in patients and controls to find genetic effects caused by rare or heterogeneous mutations. In this study, we demonstrate how mismatch repair detection on tag arrays can be applied in a case-control study. Mismatch repair detection allows >1,000 amplicons to be screened for variations in a single laboratory reaction. Variation scanning in 939 amplicons, mostly in coding regions within a linkage peak, was done for 372 patients and 404 controls. In total, >180 Mb of DNA was scanned. Several variants more prevalent in patients than in controls were identified. This study demonstrates an approach to the discovery of susceptibility genes for common disease: large-scale direct sequence comparison between patients and controls. We believe this approach can be scaled up to allow sequence comparison in the whole-genome coding regions among large sets of cases and controls at a reasonable cost in the near future.
[Tissue specificity of monoclonal antibodies to cells of human pulmonary adenocarcinoma]. (1990)

Immunohistological localization of antigens revealed by 5 MoAbs to human lung adenocarcinoma cell line was studied by indirect immunoperoxidase technique. One of the MoAbs--A2F4--showed a relative specificity to epithelial tissues having a glandular differentiation. Except approximately 50% of normal cells of lungs and those of pulmonary tumours (mostly adenocarcinomas) they reacted with some other normal (stomach, oesophagus, breast) and tumoral (gastric, mammary and colonic) tissue cells. Other four MoAbs reacted with the much larger number of cells including some nonepithelial (granulocytes and histiocytes) ones.
A Unified Linear-Time Framework for Sentence-Level Discourse Parsing (2019)

We propose an efficient neural framework for sentence-level discourse analysis in accordance with Rhetorical Structure Theory (RST). Our framework comprises a discourse segmenter to identify the elementary discourse units (EDU) in a text, and a discourse parser that constructs a discourse tree in a top-down fashion. Both the segmenter and the parser are based on Pointer Networks and operate in linear time. Our segmenter yields an $F_1$ score of 95.4, and our parser achieves an $F_1$ score of 81.7 on the aggregated labeled (relation) metric, surpassing previous approaches by a good margin and approaching human agreement on both tasks (98.3 and 83.0 $F_1$).
Simple and inexpensive three-step rapid amplification of cDNA 5′ ends using 5′ phosphorylated primers (2012)

Rapid amplification of cDNA 5' ends (5'-RACE) is routinely used for the sequence analysis of the upstream noncoding regions of cellular mRNAs; however, it represents a tedious and cost-intensive procedure. By employing 5' phosphorylated gene-specific primers for first-strand cDNA synthesis, we cut short the previously established reverse ligation and amplification protocol of Mandl and coworkers (BioTechniques, 1991, vol. 10, pp. 484-486) to a streamlined three-step procedure that no longer depends on enzymatic mRNA decapping or linker ligation. The novel three-step protocol has been validated by mapping the transcriptional start sites of heterologously expressed yellow fever virus genomic RNAs from cultured mammalian cells.
Advances in transmission over a few-mode fiber: State of the art and research results (2014)

We investigate the design of erbium-doped fiber amplifiers for few-mode fiber supporting two mode groups at the signal wavelength. We investigate the achievable gain region, gain equalization and system sensitivity to pump perturbations.
Estudo analítico-experimental de um mecanismo articulado para manipulação remota (1978)

The main concern of this work is to develop a basic experimental-analytic study which aims to design an articulated arm to be used in a remote handling device. An articulated spherical joint system has been idealized and a prototype of this system, developed. A solution to the joint stability problem is proposed as well as the joint friction has its behavior modeled throughout a matematical formulation. The calculational framework considers the overall system as an arm working as an horizontal cantilever beam having one of its ends free. Measurements on the prototype static deflections were performed to prove the consistence of the matematical model proposed.