gebhart/patrepeval huggingface dataset:
Novosphingobium and Its Potential Role in Chronic Obstructive Pulmonary Diseases: Insights from Microbiome Studies (2014)

Bacterial infection of lung airways underlies some of the main complications of COPD, significantly impacting disease progression and outcome. Colonization by bacteria may further synergize, amplify, or trigger pathways of tissue damage started by cigarette smoke, contributing to the characteristic airway inflammation and alveolar destruction of COPD. We sought to elucidate the presence and types of lung bacterial populations in different stages of COPD, aimed at revealing important insights into the pathobiology of the disease. Sequencing of the bacterial small subunit ribosomal RNA gene in 55 well-characterized clinical lung samples, revealed the presence of Novosphingobium spp. (>2% abundance) in lungs of patients with GOLD 3-GOLD 4 COPD, cystic fibrosis and a subset of control individuals. Novosphingobium-specific quantitative PCR was concordant with the sequence data and high levels of Novosphingobium spp. were quantifiable in advanced COPD, but not from other disease stages. Using a mouse model of subacute lung injury due to inhalation of cigarette smoke, bronchoalveolar lavage neutrophil and macrophage counts were significantly higher in mice challenged intratracheally with N. panipatense compared to control mice (p<0.01). Frequencies of neutrophils and macrophages in lung tissue were increased in mice challenged with N. panipatense at room air compared to controls. However, we did not observe an interaction between N. panipatense and subacute cigarette smoke exposure in the mouse. In conclusion, Novosphingobium spp. are present in more severe COPD disease, and increase inflammation in a mouse model of smoke exposure.
Immunity in strain 2 guinea-pigs inoculated with vaccinia virus recombinants expressing varicella-zoster virus glycoproteins I, IV, V or the protein product of the immediate early gene 62 (1992)

The immunogenicity of specific varicella-zoster virus (VZV) proteins, with emphasis upon cell-mediated immune responses, was evaluated by immunizing strain 2 guinea-pigs with vaccinia virus recombinants that express gpI (vac-gpI), gpIV (vac-gpIV) and gpV (vac-gpV) or the IE-62 protein (vac-IE-62). Vac-gpI elicited the highest initial mean T cell proliferation response [stimulation index (S.I.) 3.8 +/- 0.9 S.E.M.] whereas inoculation with vac-gpV produced the lowest primary T cell response (S.I. 2.5 +/- 1.1 S.E.M.). T cell proliferation was detected for a shorter period after immunization with vac-gpV compared to vac-gpI, vac-gpIV or vac-IE-62. A comparison of the immunogenicity of vac-gpI and vac-IE-62 with the same proteins prepared by immunoaffinity purification showed that immunization with these proteins in either form elicited virus-specific IgG antibodies and T cell recognition. The presence or absence of IgG antibodies to the IE-62 protein was used to assess protection against challenge with guinea-pig cell-adapted infectious VZV in animals that had been inoculated with vac-gpI, vac-gpIV or vac-gpV. Immunization with vac-gpI and vac-gpIV restricted VZV replication but all animals given vac-gpV developed antibodies to IE-62 after challenge with infectious VZV. Priming of the T lymphocyte response was observed in all animals immunized with VZV-vaccinia virus recombinants after subsequent exposure to infectious VZV. These experiments with VZV vac-gpI, vac-gpIV and vac-gpV in guinea-pigs suggest variability in the capacity of herpesviral glycoproteins to elicit cell-mediated immunity in vivo. Induction of virus-specific immunity using IE-62 means that this major tegument protein of VZV could be a useful component for vaccine development.
Wait-free parallel algorithms for the union-find problem (1991)

Article Wait-free parallel algorithms for the union-find problem Share on Authors: Richard J. Anderson Univ. of Washington, Seattle Univ. of Washington, SeattleView Profile , Heather Woll Univ. of California, San Diego Univ. of California, San DiegoView Profile Authors Info & Claims STOC '91: Proceedings of the twenty-third annual ACM symposium on Theory of ComputingJanuary 1991 Pages 370–380https://doi.org/10.1145/103418.103458Online:03 January 1991Publication History 71citation909DownloadsMetricsTotal Citations71Total Downloads909Last 12 Months38Last 6 weeks9 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A retrospective study of dento‐alveolar injuries (1994)

Abstract Traumatic injuries to primary and permanent dentition may lead to severe therapeutic problems. The purpose of the investigation was to evaluate epidemiologic data of dentoalveolar injuries collected in a university dental clinic. The sample consisted of 300 patients (198 boys, 102 girls) representing 480 injured teeth, mostly maxillary incisors (94.6%). The results pointed‐out a high predominance of traumatized primary teeth. Types of injuries differed between deciduous and permanent dentition: luxation injuries were most often recorded in primary dentition (81%), while a high percentage of crown and crown‐root fractures were recorded in permanent dentition (38%). Epidemiological observations concerning location, etiology and distribution of dento‐alveolar injuries are briefly discussed.
Targeting phosphoinositide 3-kinase γ to fight inflammation and more (2008)

The family of class I phosphoinositide-3-kinase (PI3K) is composed of four lipid kinases involved at multiple levels in innate and adaptive immune responses. Class I PI3Ks are divided into two subclasses, IA and IB, sharing a similar catalytic core. Whereas class IA PI3Ks are primarily activated by receptor tyrosine kinases, the unique element of class IB PI3K (PI3Kgamma) is activated by G protein coupled receptors (GPCRs), like chemokine receptors. PI3Kgamma is mainly expressed in leukocytes where it plays a significant role in chemotaxis. Here, we report recent advances in the analysis of the role of PI3Kgamma in leukocytes and in endothelial cells. Results, derived from studies based on both pharmacological and genetic approaches, confirm PI3Kgamma as an attractive target for drug discovery. PI3Kgamma specific inhibition has gained increasing attention for the treatment of allergic, autoimmune and inflammatory diseases. Development of inhibitors has already provided series of hits, whose efficacy is currently under scrutiny worldwide.
Targeted Germline Modifications in Rats Using CRISPR/Cas9 and Spermatogonial Stem Cells (2015)

Organisms with targeted genomic modifications are efficiently produced by gene editing in embryos using CRISPR/Cas9 RNA-guided DNA endonuclease. Here, to facilitate germline editing in rats, we used CRISPR/Cas9 to catalyze targeted genomic mutations in rat spermatogonial stem cell cultures. CRISPR/Cas9-modified spermatogonia regenerated spermatogenesis and displayed long-term sperm-forming potential following transplantation into rat testes. Targeted germline mutations in Epsti1 and Erbb3 were vertically transmitted from recipients to exclusively generate "pure," non-mosaic mutant progeny. Epsti1 mutant rats were produced with or without genetic selection of donor spermatogonia. Monoclonal enrichment of Erbb3 null germlines unmasked recessive spermatogenesis defects in culture that were buffered in recipients, yielding mutant progeny isogenic at targeted alleles. Thus, spermatogonial gene editing with CRISPR/Cas9 provided a platform for generating targeted germline mutations in rats and for studying spermatogenesis.
Synaesthesia in phantom limbs induced with mirrors (1996)

Although there is a vast clinical literature on phantom limbs, there have been no experimental studies on the effects of visual input on phantom sensations. We introduce an inexpensive new device--a 'virtual reality box'--to resurrect the phantom visually to study inter-sensory effects. A mirror is placed vertically on the table so that the mirror reflection of the patient's intact had is 'superimposed' on the felt position of the phantom. We used this procedure on ten patients and found the following results. 1. In six patients, when the normal hand was moved, so that the phantom was perceived to move in the mirror, it was also felt to move; i.e. kinesthetic sensations emerged in the phantom. In D.S. this effect occurred even though he had never experienced any movements in the phantom for ten years before we tested him. He found the return of sensations very enjoyable. 2. Repeated practice led to a permanent 'disappearance' of the phantom arm in patient D.S. and the hand became telescoped into the stump near the shoulder. 3. Using an optical trick, impossible postures--e.g. extreme hyperextension of the fingers--could be induced visually in the phantom. In one case this was felt as a transient 'painful tug' in the phantom. 4. Five patients experienced involuntary painful 'clenching spasms' in the phantom hand and in four of them the spasms were relieved when the mirror was used to facilitate 'opening' of the phantom hand; opening was not possible without the mirror. 5. In three patients, touching the normal hand evoked precisely localized touch sensations in the phantom. Interestingly, the referral was especially pronounced when the patients actually 'saw' their phantom being touched in the mirror. Indeed, in a fourth patient (R.L.) the referral occurred only if he saw his phantom being touched: a curious form of synaesthesia. These experiments lend themselves readily to imaging studies using PET and fMRI. Taken collectively, they suggest that there is a considerable amount of latent plasticity even in the adult human brain. For example, precisely organized new pathways, bridging the two cerebral hemispheres, can emerge in less than three weeks. Furthermore, there must be a great deal of back and forth interaction between vision and touch, so that the strictly modular, hierarchical model of the brain that is currently in vogue needs to be replaced with a more dynamic, interactive model, in which 're-entrant' signalling plays the main role.
Image Registration For Super Resolution Using Scale Invariant Feature Transform, Belief Propagation And Random Sampling Consensus (2010)

Publication in the conference proceedings of EUSIPCO, Aalborg, Denmark, 2010
Platinum in the Glass Industry (1987)

Platinum and its alloys have long been accepted as essential materials for the fabrication of equipment used in the glass industry. However the superior mechanical properties of the zirconia grain stabilised materials developed by Johnson Matthey have led to their successful utilisation for many of the most demanding applications; for others conventional platinum group metals and alloys are still preferred and both types of material are considered here.
Absolute structure determination of compounds with axial and planar chirality using the crystalline sponge method (2015)

The absolute stereochemistry of compounds with axial and planar chirality is successfully determined by the crystalline sponge method without crystallization or derivatization of the compounds. This method is applied to absolute structure determination in the asymmetric synthesis of unique compounds with axial and planar chirality.
Highly efficient waveguided laser performance of diode pumped unclad Yb:YAG crystalline fibre (2016)

Single crystal fibre (SCF), as most often used in the literature today, is the term referring to a relatively thin (under 1 mm diameter) and pretty short (30–60 mm long), unclad single-crystalline rod surrounded by air, in a laser configuration where the pump power is waveguided by the total internal reflection of the cylindrical circumference. In previous reports on SCF lasers the pump is flood-illuminating the volume of the gain medium, while the generated laser signal is in a free propagation mode inside the laser rod, i.e. the laser mode structure is defined solely by the external cavity mirror configuration. Presented here are the experimental laser results obtained with the diode-pumped, 100 μm diameter, 100 mm long, unclad Yb:YAG crystalline fibre, wherein both pump light and generated laser power are waveguided. To the best of our knowledge, the demonstrated laser operation is based on the thinnest and the longest unclad fibre reported so far. It is also believed to be the first reported true waveguided laser operation from an unclad single crystalline fibre. Laser efficiency of over 58% obtained with no antireflective coatings on fibre ends is a manifestation of low composite loss figure, inclusive of both material bulk and waveguiding loss.
Assessing nutritional state in inflammatory bowel disease. (1986)

Nutrient depletion is a common complication of inflammatory bowel disease, and some of the consequences can be severe. Although it is often easy to recognise the most severely undernourished subjects, those with lesser degrees of malnutrition may prove more difficult to detect. Measurements of many nutritional variables will be abnormal in patients with inflammatory bowel disease, especially in those with Crohn's disease, but are not always relevant to the clinical management of patients. Anthropometric means of assessment, in particular, measurement of mid arm circumference, can act as a simple, reproducible method of detecting those most at risk of appreciable undernutrition.
Coupling Reaction of Phenylacetylene with OsH<i><sub>n</sub></i>(PPh<sub>3</sub>)(2,6-(PPh<sub>2</sub>CH<sub>2</sub>)<sub>2</sub>C<sub>6</sub>H<sub>3</sub>) (<i>n</i> = 1, 3) (2003)

Treatment of OsCl(CCHPh)(PPh3)(PCP) with thallium acetate produces the vinylidene complex Os(O2CCH3)(CCHPh)(PCP). Treatment of OsCl(PPh3)(PCP) with NaH in wet THF produces a mixture of the monohydride OsH(PPh3)(PCP) and the trihyhride OsH3(PPh3)(PCP). The latter complexes react with phenylacetylene to give Os(C⋮CPh)(CCHPh)(PPh3)(1-(CHPhC)-2,6-(PPh2CH2)2C6H3).
Oxidative stress in heart failure More than just damage (2003)

See doi:10.1016/j.ehj.2003.09.022for the article to which this editorial refers 

Chronic heart failure (CHF) continues to cause substantial morbidity and mortality despite major therapeutic advances, such as the use of angiotensin-converting enzyme (ACE) inhibitors and β-blockers. The main causes of CHF today are ischaemic heart disease (IHD) and hypertension. Extensive experimental and clinical studies over the last 20 years have established that a fundamental process in the progression to CHF (especially in patients with prior myocardial infarction [MI]) is cardiac remodelling—a series of alterations in heart structure and function that involve significant changes in gene expression and protein function, both in the extracellular matrix and in cardiomyocytes. Although ventricular remodelling may initially be adaptive by normalizing wall stress and maintaining contractile function in the face of muscle loss or increased load, with time there is progressive ventricular dilatation, increasing interstitial fibrosis and arrhythmia, and a decline in ejection fraction. At least part of the benefit of ACE inhibitors and β-blockers is believed to involve the amelioration of adverse cardiac remodelling.

The poor prognosis of CHF despite the use of multiple evidence-based therapies has provided an impetus for the elucidation of new pathophysiological pathways that could be therapeutically targeted to improve patient outcome. Two such pathways that have received increasing attention are (a) the activation of matrix metalloproteinases (MMPs), a family of enzymes capable of degrading all the matrix components of the heart, and (b) myocardial oxidative stress. MMPs are critically important in determining the balance between matrix deposition and degradation, which ultimately influences chamber size, shape and function. The inappropriate activation of MMPs and/or an imbalance between their actions and those of tissue inhibitors …
The Fully Digital Controlled Corrector Magnet Power Converter (2010)

This paper presents an implementation of a precision corrector magnet power converter using the digitally controlled pulse width modulation method. The output current precision of this ±10A/±50V corrector magnet power converter is within ±10ppm. The digital control circuit of the power converter is implemented with using a high speed ADS8382 18-bits analog-to-digital converter and a TMS320F28335 digital signal processor. The converter uses a full bridge configuration, the switching frequency of power MOSFET is 40 kHz and the control resolution is 17-bits. Using a DCCT as the current feedback component the output current ripple of this converter could be lower than 5 ppm that is beyond the requirement of TLS corrector power converter and suitable to be used in TPS.
Phytolectins: natural molecules with immense biotechnological potential. (1997)

Lectins are structurally diverse, carbohydrate binding proteins that bind reversibly to specific mono- or oligosaccharides. Their abundance in the plant kingdom suggest that they have diverse roles to perform. They serve as recognition factor between symbiotic nitrogen fixing bacteria and host plants, as a deterrent to phytopathogens like fungi, insects, and animals, as storage protein and as an aid in sexual reproduction in Chlamydomonas, amongst others. The possible application of lectins as a factor in increasing soil fertility and as a biopesticide by genetically engineered organisms is yet to be fully explored by the biotechnologists. However, they are being used by the biomedical scientists and biochemists in blood typing and stimulation of cells for chromosome analysis and gene mapping, in cell separation, identification of complex glycoproteins and typing of bacteria. Cell targeting by lectins in cancer therapy is still in its infancy. This review gives an insight into the potential of these wonder biomolecules in agriculture, biochemistry, cell biology and medicine for the benefit of mankind.
Unsupervised Anomaly detection of LM Guide Using Variational Autoencoder (2019)

Linear Motion (LM) is a linear motion guide that helps directional moving of machine. It is important to judge the anomaly state of LM guides because LM guides are used in various industries to support various task in industry application. In this paper, we proposed a machine learning algorithm for determining the anomaly state of LM guide. Considering that it is difficult to actually generate the anomaly signal, we trained model with only healthy state data. One of the generative models, variational autoencoder, is used for training healthy state data and the distribution of healthy state data is trained. Our trained model determines whether or not anomaly state has occurred based on a reconstruction error of the trained network.
A metallothionein and CPx‐ATPase handle heavy‐metal tolerance in the filamentous cyanobacterium <i>Oscillatoria brevis</i> <sup>1</sup> (2003)

A metallothionein (BmtA) and a CPx-ATPase (Bxa1) have been identified and characterized from the cyanobacterium Oscillatoria brevis. Both bmtA and bxa1 expression can be markedly induced in vivo by Zn(2+) or Cd(2+). Over-expression of bmtA or bxa1 in Escherichia coli enhances Zn(2+) and Cd(2+) tolerance in the transformant. Dynamic studies on the expression of two genes showed that the maximum expression of bxa1 induced by Zn(2+) and Cd(2+) was much quicker than that of bmtA, suggesting distinct physiological roles of metallothionein and CPx-ATPase in the handling of surplus metal.
Stimulation of Benzyladenine-Induced in Vitro Shoot Organogenesis and Endogenous Proline in Melon (<i>Cucumis melo</i> L.) by Fish Protein Hydrolysates in Combination with Proline Analogues (1999)

A previous study demonstrated that proline is beneficial for improving melon in vitro shoot organogenesis. A natural source of proline and proline precursors can be obtained from fish protein hydrolysates (FPH), a byproduct of the fishery industry. Proline analogues azetidine-2-carboxylate and hydroxyproline in combination with standardized FPH were used to stimulate proline synthesis and benzyladenine-induced shoot organogenesis by exploiting the proposed proline-linked pentose phosphate pathway (PPP). In the presence of elevated levels of endogenous proline, potential stimulation of cytokinins and auxin may occur via the PPP and shikimate pathways, respectively. Treatments with FPH singly and in combination with the above proline analogues significantly increased the endogenous proline content and the extent of differentiation, suggesting that in vitro organogenesis is closely linked to proline synthesis, strengthening the hypothesis that purine metabolism via the proline-linked PPP may be important for organogenesis. Thioproline addition resulted in increased proline levels but without corresponding stimulation of organogenesis. This study also provides potential use of fishery waste for value-added application in plant micropropagation industry.
í‚ngela Maria Paiva Cruz. Representação da Estrutura Lógica da Geometria da Cubação (2010)

Resenha
A personalized music recommendation system with a time-weighted clustering (2008)

We propose a music recommendation system which provides personalized services. The system keeps a userpsilas listening list and analyzes it to select pieces of music similar to the userpsilas preference. For analysis, the system extracts properties from the sound wave of music and the time when the user listens to music. Based on the properties, a pieces of music is mapped into a point in the property space and the time is converted into the weight of the point. The more recently the user listens to the music, the more the weight increases. We apply the K-means clustering algorithm to the weighted points. The K-means algorithm is modified so that the number of clusters are dynamically changed. By using our K-means clustering algorithm, we can recommend pieces of music which are close to userpsilas preference even though he likes several genres. We also consider the time when music is released. When recommending, the system selects pieces of music which is close to and released contemporarily with the userpsilas preference. We perform experiments with one hundred pieces of music. In this paper we present and evaluate algorithms to recommend system.
Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization (2019)

Electrospinning is a method of preparing microfibers or nanofibers by using an electrostatic force to stretch the electrospinning fluid. Electrospinning has gained considerable attention in many fields due to its ability to produce continuous fibers from a variety of polymers and composites in a simple way. Electrospun nanofibers have many merits such as diverse chemical composition, easily adjustable structure, adjustable diameter, high surface area, high porosity, and good pore connectivity, which give them broad application prospects in the biomedical field. This review systematically introduced the factors influencing electrospinning, the types of electrospun fibers, the types of electrospinning, and the detailed applications of electrospun fibers in controlled drug release, biological dressings, tissue repair and enzyme immobilization fields. The latest progress of using electrospun fibers in these fields was summarized, and the main challenges to be solved in electrospinning technology were put forward.