gebhart/patrepeval huggingface dataset:
A CC′ Loop Decoy Peptide Blocks the Interaction Between Act1 and IL-17RA to Attenuate IL-17– and IL-25–Induced Inflammation (2011)

Interleukin-17 (IL-17) and IL-25 signaling induce the expression of genes encoding inflammatory factors and are implicated in the pathology of various inflammatory diseases. Nuclear factor κB (NF-κB) activator 1 (Act1) is an adaptor protein and E3 ubiquitin ligase that is critical for signaling by either IL-17 or IL-25, and it is recruited to their receptors (IL-17R and IL-25R) through heterotypic interactions between the SEFIR [SEF (similar expression to fibroblast growth factor genes) and IL-17R] domain of Act1 and that of the receptor. SEFIR domains have structural similarity with the Toll-IL-1 receptor (TIR) domains of Toll-like receptors and IL-1R. Whereas the BB' loop of TIR is required for TIR-TIR interactions, we found that deletion of the BB' loop from Act1 or IL-17RA (a common subunit of both IL-17R and IL-25R) did not affect Act1-IL-17RA interactions; rather, deletion of the CC' loop from Act1 or IL-17RA abolished the interaction between both proteins. Surface plasmon resonance measurements showed that a peptide corresponding to the CC' loop of Act1 bound directly to IL-17RA. A cell-permeable decoy peptide based on the CC' loop sequence inhibited IL-17- or IL-25-mediated signaling in vitro, as well as IL-17- and IL-25-induced pulmonary inflammation in mice. Together, these findings provide the molecular basis for the specificity of SEFIR-SEFIR versus TIR-TIR domain interactions and consequent signaling. Moreover, we suggest that the CC' loop motif of SEFIR domains is a promising target for therapeutic strategies against inflammatory diseases associated with IL-17 or IL-25 signaling.
A Process For Monolithic Fabrication Of Microlenses On Integrated Circuits (1988)

A microlens fabrication process is described which is based on commercially available IC processing materials. The lenses are formed on top of circular pedestals by melting a photoresist developed in a suitable pattern. Due to surface tension forces melting leads to formation of a spherical surface which is pinned by the sharp edge of the pedestal. The process gives microlenses of excellent quality which show diffraction limited resolution.
Conventional Frequency Ultrasonic Biomarkers of Cancer Treatment Response In Vivo (2013)

The results obtained in this research demonstrate that quantitative ultrasound at a clinically relevant frequency can monitor tissue changes in vivo in response to cancer treatment administration. Using higher order textural information extracted from quantitative ultrasound spectral parametric maps provides more information at a high sensitivity related to tumor cell death.
Compact, “Clickable” Quantum Dots Photoligated with Multifunctional Zwitterionic Polymers for Immunofluorescence and <i>In Vivo</i> Imaging (2020)

We detail the preparation of highly fluorescent quantum dots (QDs), surface-engineered with multifunctional polymer ligands that are compact and readily compatible with strain-promoted click conjugation, and the use of these nanocrystals in immunofluorescence and <i>in vivo</i> imaging. The ligand design combines the benefits of mixed coordination (i.e., thiol and imidazole) with zwitterion motifs, yielding sterically-stabilized QDs that present a controllable number of azide groups, for easy conjugation to biomolecules <i>via</i> the selective click chemistry. The polymer coating was characterized using NMR spectroscopy to extract estimates of the diffusion coefficient, hydrodynamic size, and ligand density. The azide-functionalized QDs were conjugated to anti-tropomyosin receptor kinase B antibody (α-TrkB) or to the brain-derived neurotrophic factor (BDNF). These conjugates were highly effective for labeling the tropomyosin receptor kinase B (TrkB) in pyramidal neurons within cortical tissue and for monitoring the BDNF induced activation of TrkB signaling in live neuronal cells. Finally, the polymer-coated QDs were applied for <i>in vivo</i> imaging of <i>Drosophila melanogaster</i> embryos, where the QDs remained highly fluorescent and colloidally stable, with no measurable cytotoxicity. These materials would be of great use in various imaging applications, where a small size, ease of conjugation, and great colloidal stability for <i>in vivo</i> studies are needed.
Aircraft Free-Space MIMO Wireless Communications (Preprint) (2008)

In Airborne Networks, because of the high mobility, a communications link is typically available for only a short period of time. Thus it is desirable to communicate at as high a data rate as possible to complete one's information transfer in the available time. High data rate suggests the use of MIMO communications, multiplexing many messages over the link by using multiple antennas at each end of the link. However, communication between aircraft is usually free of scattered propagation (free space propagation), while MIMO performs best in a highly scattered environment. Nevertheless, MIMO is not necessarily ruled out in such a free space environment, providing the radio frequency is high enough, the link distance is short enough, and the antenna arrays are wide enough. We will show how nearly full data rate advantage characteristic of MIMO links can be achieved in the presence of free space propagation by means of typical examples.
Mutagenesis of Trichoderma reesei endoglucanase I: impact of expression host on activity and stability at elevated temperatures (2015)

Structure-guided evolution of T. reesei EGI was used to engineer enzymes with increased thermal stability and activity on solid cellulosic substrates. Production of TrEGI enzymes in four hosts highlighted the impact of the expression host and the role of N-terminal pyroglutamate formation on the activity and stability of TrEGI enzymes.
A Cobalt‐Catalyzed One‐Step Synthesis of Annelated Pyridines (1977)

5,6,7,8‐Tetrahydroisoquinolines and other relatively inaccessible annelated pyridines (3) are now available by the reaction sequence (1) + (2) → (3) . This synthesis is much simpler and otherwise superior to previous methods. equation image
NEXT GENERATION PULSATILE VAD (2003)

The optimized HeartSaver VAD (HSVAD) is a miniaturized, bearingless, pulsatile, fully implantable ventricular assist system. Half the size of first-generation pulsatile systems, it retains their physiological pumping mechanism while eliminating their complexity and need for a volume compensator when fully implantable. The pump/drive unit incorporates two small pump chambers connected in series. A single, common, pusher plate is positioned between the valveless pre-chamber and the two-valved pumping chamber. The pre-chamber fills as the pumping chamber ejects. During the return stroke, fluid transfers from the pre-chamber to the pumping chamber, with no net inflow or outflow. Since the combined volume of the two chambers remains constant throughout the cycle, no volume compensator is required. The pusher plate, supported by the two pump diaphragms, is driven by direct magnetic actuation, without coupling members or bearings. Eject bias springs are compressed during the return stroke and deliver their stored energy during the eject stroke, efficiently utilizing the driver throughout the pumping cycle and leveling the power load through the system. The driver's linear force versus current characteristics enhance system control capabilities. A prototype system has been tested on a mock loop with analog LV. The VAD provided ventricular unloading while generating physiologic stroke volumes and flows. The controls system demonstrated sensitivity to preload, with pump actuation responsive to LV activity.
Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo (1986)

A structure-activity analysis of peptides containing backbone C alpha-methyl and N alpha-methyl modifications led to the discovery of potent renin inhibitors with high metabolic stability. In vitro, Boc-Pro-Phe-N alpha-MeHis-Leu psi-[CHOHCH2]Val-Ile-Amp (XII) is a potent inhibitor of human plasma renin with IC50 of 0.26 nM. It is a much weaker inhibitor of other aspartic proteases such as porcine pepsin or bovine cathepsin D (IC50 = 6 microM). It was shown not to be degraded by a rat liver homogenate preparation. In vivo, it inhibited plasma renin activity and lowered blood pressure of furosemide-treated cynomolgus monkeys. At a dose of 5 mg/kg iv, the pronounced hypotensive response persisted for greater than 3 h postinfusion.
Continual computation policies for utility-directed prefetching (1998)

Article Free Access Share on Continual computation policies for utility-directed prefetching Author: Eric Horvitz Microsoft Research, One Microsoft way, Redmond, WA Microsoft Research, One Microsoft way, Redmond, WAView Profile Authors Info & Claims CIKM '98: Proceedings of the seventh international conference on Information and knowledge managementNovember 1998Pages 175–184https://doi.org/10.1145/288627.288655Published:01 November 1998Publication History 16citation275DownloadsMetricsTotal Citations16Total Downloads275Last 12 Months7Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Fast block noncoherent decoding (2001)

We present a fast algorithm for exact maximum-likelihood multisymbol noncoherent phase-shift keying decoding. While the standard algorithm is exponential in the rate and the block length, our algorithm is rate independent and linear-logarithmic in the block length.
A new mechanism for negative refraction and focusing using selective diffraction from surface corrugation (2007)

Refraction at a smooth interface is accompanied by momentum transfer normal to the interface. We show that corrugating an initially smooth, totally reflecting, non-metallic interface provides a momentum kick parallel to the surface, which can be used to refract light negatively or positively. This new mechanism of negative refraction is demonstrated by visible light and microwave experiments on grisms (grating-prisms). Single-beam all-angle-negative-refraction is achieved by incorporating a surface grating on a flat multilayered material. This negative refraction mechanism is used to create a new optical device, a grating lens. A plano-concave grating lens is demonstrated to focus plane microwaves to a point image. These results show that customized surface engineering can be used to achieve negative refraction even though the bulk material has positive refractive index. The surface periodicity provides a tunable parameter to control beam propagation leading to novel optical and microwave devices.
Fluorogenic Substrates for Visualizing Acidic Organelle Enzyme Activities (2016)

Lysosomes are acidic cytoplasmic organelles that are present in all nucleated mammalian cells and are involved in a variety of cellular processes including repair of the plasma membrane, defense against pathogens, cholesterol homeostasis, bone remodeling, metabolism, apoptosis and cell signaling. Defects in lysosomal enzyme activity have been associated with a variety of neurological diseases including Parkinson's Disease, Lysosomal Storage Diseases, Alzheimer's disease and Huntington's disease. Fluorogenic lysosomal staining probes were synthesized for labeling lysosomes and other acidic organelles in a live-cell format and were shown to be capable of monitoring lysosomal metabolic activity. The new targeted substrates were prepared from fluorescent dyes having a low pKa value for optimum fluorescence at the lower physiological pH found in lysosomes. They were modified to contain targeting groups to direct their accumulation in lysosomes as well as enzyme-cleavable functions for monitoring specific enzyme activities using a live-cell staining format. Application to the staining of cells derived from blood and skin samples of patients with Metachromatic Leukodystrophy, Krabbe and Gaucher Diseases as well as healthy human fibroblast and leukocyte control cells exhibited localization to the lysosome when compared with known lysosomal stain LysoTracker® Red DND-99 as well as with anti-LAMP1 Antibody staining. When cell metabolism was inhibited with chloroquine, staining with an esterase substrate was reduced, demonstrating that the substrates can be used to measure cell metabolism. When applied to diseased cells, the intensity of staining was reflective of lysosomal enzyme levels found in diseased cells. Substrates specific to the enzyme deficiencies in Gaucher or Krabbe disease patient cell lines exhibited reduced staining compared to that in non-diseased cells. The new lysosome-targeted fluorogenic substrates should be useful for research, diagnostics and monitoring the effect of secondary therapeutic agents on lysosomal enzyme activity in drug development for the lysosomal storage disorders and allied diseases.
Schmallenberg virus challenge models in cattle: infectious serum or culture-grown virus? (2012)

Schmallenberg virus (SBV), discovered in Europe in 2011, causes mild transient disease in adult ruminants, but fetal infection can lead to severe malformation in cattle, sheep and goats.To elucidate the pathogenesis of this novel orthobunyavirus, considerable efforts are required. A reliable and standardized infection model is essential for in vivo studies. In the present study, two groups of four cattle were inoculated with either serum passaged in cattle only or cell culture-grown virus. The replication of culture-grown SBV in cattle was reduced compared to virus inoculated via infectious serum. In a second experiment, the infectious serum was titrated in calves; the tested batch contained 102.83 infectious doses per mL. Hence, serum-borne virus that was only passaged in the natural host is a suitable option for a standardized SBV infection model.
Silicate Enhanced Enzymatic Dehairing:  A New Lime-Sulfide-Free Process for Cowhides (2005)

A conventional dehairing process with sodium sulfide and lime is a major source of the pollution from the tanning industry. In other words, conventional dehairing processes degrade the hair to the extent that it cannot be recovered; thus, these processes become a major contributor to wastewater pollution. In this study, an attempt has been made to develop a lime and sulfide-free dehairing process using a commercial enzyme formulation with the activation of a silicate salt. A dip and pile method of application has been standardized. The amount of enzyme and sodium metasilicate has also been optimized based on complete removal of hair. Enhancement of enzyme activity by the addition of silicate has been demonstrated through activity measurements. Hair removal is found to be complete using scanning electron microscope analysis. Strength and bulk properties of the experimental leathers are comparable to that of control leathers. The process enjoys a significant reduction in chemical oxygen demand (COD) and total solids (TS) by 53 and 26%, respectively. More importantly, the application of enzyme for dehairing results in an 8% area increase in the final leather. Also, the process is proven to be techno-economically feasible.
Access to Highly Functionalized Cyclopentenones via Diastereoselective Pauson–Khand Reaction of Siloxy-Tethered 1,7-Enynes (2019)

A diastereoselective Co<sub>2</sub>(CO)<sub>8</sub>-mediated Pauson-Khand reaction (PKR) of siloxy-tethered 1,7-enynes for the synthesis of cyclopentaoxasilinones has been developed. This transformation can be performed on a multigram scale and is characterized by a broad substrate scope, functional group compatibility, and high chemo- and diastereoselectivity. Oxidation of the resulting cyclopentaoxasilinones delivers stereoenriched β-alkylated cyclopentenones, which are inaccessible by intermolecular PKRs. This research provides a practical solution to the challenges associated with the classical intermolecular PKR.
ChemInform Abstract: Synthesis of Imidazo(1,5‐c)pyrimidine Derivatives. (1987)

Abstract 6‐Aminomethyluracil (II), obtained from the chloromethyl derivative (I), is converted to the acyl derivatives (III).
Compressive spectral X-ray tomography based on spatial and spectral coded illumination (2019)

Spectral computed tomography (CT) relies on the spectral dependence of X-ray attenuation coefficients to separate projection measurements into more than two energy bins. Such data can be used to unveil tomographic material characterization - key in national security and medical imaging. This paper explores a radical departure from conventional methods used in spectral imaging. It relies on K-edge coded apertures to create spatially and spectrally coded, lower-dose, X-ray bundles that interrogate specific voxels of the object. The new approach referred to as compressive spectral X-ray imaging (CSXI) uses low-cost standard X-ray integrating detectors and acquires compressive measurements, which enable the reconstruction of energy binned images from fewer measurements. Various spectral and spatial coding strategies for structured illumination are explored. Subsampling in CSXI is accomplished by either view angle spectral subsampling, spatial subsampling enabled by block-unblock coded apertures placed at the source or detector side, or both. The careful design of subsampling strategies, spectral filters, coded apertures, and their placement, are shown to be critical for the quality of tomographic image reconstruction. The forward imaging model of CSXI, which is a non-linear ill-posed problem, is analyzed and a multi-stage algorithm is developed to address the estimation of the energy binned sinograms from the integrating detector measurements. Then, an Alternating Direction Method of Multipliers (ADMM) is used to solve a joint sparse and low-rank optimization problem for reconstruction that exploits the structure of the spectral X-ray data cube.
Dehydrated Human Amnion/Chorion Membrane (dHACM) Allografts as a Therapy for Orthopedic Tissue Repair (2017)

The amniotic membrane is a placental tissue that supports the development of the fetus during pregnancy. It is composed of extracellular matrix components such as collagen, fibronectin, and laminin, and contains many different growth factors and cytokines. Amniotic membrane can be PURION ® Processed to produce dehydrated human amnion/chorion membrane (dHACM, Epifix, Amniofix; MiMedx Group Inc.) allografts. This tissue has been shown in randomized clinical trials to be effective for healing chronic foot and leg ulcers, and has demonstrated the ability to promote the migration of stem cells in vitro and to recruit stem cells to a wound site in vivo. Owing to its regenerative properties, amniotic membrane and dHACM allografts have more recently been implicated as an alternative or supplemental therapy in the treatment of orthopedic tissue injuries such as plantar fasciitis, tendinopathy, and vertebral fusion procedures. In this review, the basic structure, function, and components of dHACM are discussed, and its current in vitro, in vivo, and clinical usages in orthopedic tissue repair applications are summarized.
Clozapine-induced agranulocytosis: non-cross-reactivity with other psychotropic drugs. (1988)

Clozapine, an atypical neuroleptic with unique clinical and preclinical properties, represents a potentially valuable addition to the psychopharmacopeia. Its development and use have been limited by its higher frequency, compared with other pharmacologic treatments, of the potentially fatal side effect of agranulocytosis. This article describes the natural history of five cases of agranulocytosis that occurred in the course of clozapine treatment. The cases were generally uniform as to onset, recovery, and hematologic features. No patient had hematologic reactions to treatment with psychotropic agents before or after clozapine treatment. These findings, along with other work in progress, suggest that clozapine's granulocytoxic effects are produced by a highly specific immune-mediated mechanism.
A New Class of Antenna Array With a Reconfigurable Element Factor (2012)

A parasitic layer-based multifunctional reconfigurable antenna array (MRAA) formed by the linear combination of four (4 1) identical multifunctional reconfigurable antenna (MRA) elements is presented. Each MRA produces eight modes of operation corresponding to three steerable beam directions ( , 0 , 30 ) with linear and circular polarizations in plane and another two steerable beam directions ( , 30 ) in plane with linear polarization. An individual MRA consists of an aperture-coupled driven patch antenna with a parasitic layer placed above it. The surface of the parasitic layer has a grid of 4 4 electrically-small rectangular-shaped metallic pixels. The adjacent pixels can be connected/disconnected by means of switching resulting in recon- figurability in beam-direction and polarization. A 4 1 linear MRAA operating in the 5.4–5.6 GHz is formed by the optimized MRA elements. MRA and MRAA prototypes have been fabricated and measured. The measured and simulated results agree well indicating 13.5 dB realized array gain and 3% common bandwidth. The MRAA presents some advantages as compared to a standard antenna array: MRAA alleviates the scan loss inherit to standard antenna arrays, provides higher gain, does not need phase shifters for beam steering in certain plane, and is capable of polarization reconfigurability.
Fujitsu HIKARI, a Healthcare Decision Support System based on Biomedical Knowledge (2021)

Fujitsu HIKARI is an artificial intelligence solution to assist clinicians in medical decision making, developed in the context of a joint collaboration project between Fujitsu Laboratories of Europe and Hospital Clínico San Carlos. This decision support system leverages on data analytics combined with healthcare semantic information to provide health estimations for patients, improving care quality and personalized treatment. Fujitsu HIKARI stands on the shoulders of biomedical knowledge, which includes (i) theoretical knowledge extracted from scientific literature, domain expert knowledge, and health standards; and (ii) empirical knowledge extracted from real patient electronic health records. The theoretical knowledge combines a theoretical knowledge graph (TKG) and a biomedical document repository (BDR). The empirical knowledge is encoded in an empirical knowledge graph (EKG). One of the main functionalities of Fujitsu HIKARI is the patient mental health risks assessment, which is based on the exploitation of its underlying Biomedical Knowledge.
Sustainable Approach to Superhydrophobic Surfaces Based on Water‐Born Electrospinning (2018)

Abstract Superhydrophobic surfaces are obtained by a sustainable approach by electrospinning of water‐based acrylate dispersion followed by mild silanization and removal of template polymer. The resulting nonwovens show very high superhydrophobicity and very low roll angle. In contrast to many other approaches, pores provide the required morphology to achieve superhydrophobicity. This new material provides a new approach to electrospun nonwoven coatings which can be of interest for textile applications.