gebhart/patrepeval huggingface dataset:
Cerebrospinal fluid F<sub>2</sub>‐isoprostane levels are increased in Alzheimer's disease (1998)

Postmortem studies have associated Alzheimer's disease (AD) with regionally increased oxidative damage to brain. Lacking, however, is a specific marker of oxidative damage to brain that may be measured during life. We tested the hypothesis that cerebrospinal fluid (CSF) concentrations of F2-isoprostanes (F2-IsoPs), stable products of arachidonate peroxidation, are increased in CSF of AD patients. CSF from lateral ventricles (VF) was analyzed from 11 AD patients and 11 control subjects who participated in a rapid autopsy program. VF F2-IsoP concentrations were significantly elevated in AD patients compared with control subjects (72 +/- 7 vs 46 +/- 4 pg/ml) and were significantly linearly correlated with brain weight (-0.3 pg/ml/g, r2 = 0.32). These results suggest that quantification of CSF F2-IsoP concentrations may provide a useful biomarker of central nervous system oxidative damage in AD.
Signaling in Telecommunication Networks (2006)

Introduction to telecommunications introduction to signalling subscriber signalling channel-associated interexchange signalling introduction to common-channel signalling Signalling System No.6 introduction to Signalling System No.7 SS7 message transfer part telephone user part digital subscriber signalling ISDN user part signalling in cellular mobile telecommunications introduction to transactions signalling connection control part transaction capabilities application part signalling in intelligent networks mobile application part.
Bortezomib induces osteoblast differentiation via Wnt-independent activation of β-catenin/TCF signaling (2009)

Inhibition of Wnt/beta-catenin/T-cell factor (TCF) signaling induces proliferation of mesenchymal stem cells and/or suppresses their differentiation into osteoblasts (OBs). Osteolysis in multiple myeloma (MM) is related to the suppression of canonical Wnt signaling caused by DKK1, a soluble inhibitor of this pathway secreted by MM cells. Bortezomib (Bzb) can induce OB differentiation in vitro and in vivo and its anti-MM efficacy linked to bone anabolic effects. However, the molecular basis of the action of Bzb on bone is not completely understood. In the present study, we show that Bzb promotes matrix mineralization and calcium deposition by osteoprogenitor cells and primary mesenchymal stem cells via Wnt-independent activation of beta-catenin/TCF signaling. Using affinity pull-down assays with immunoblotting and immunofluorescence, we found that Bzb induced stabilization of beta-catenin. Nuclear translocation of stabilized beta-catenin was associated with beta-catenin/TCF transcriptional activity that was independent of the effects of Wnt ligand-receptor-induced signaling or GSK3beta activation. Blocking the activation of beta-catenin/TCF signaling by dominant negative TCF attenuated Bzb-induced matrix mineralization. These results provide evidence that Bzb induces OB differentiation via Wnt-independent activation of beta-catenin/TCF pathway and suggest that proteasome inhibition therapy in MM may function in part by subverting tumor-induced suppression of canonical Wnt signaling in the bone microenvironment.
<title>Correlation tracking based on wavelet domain information</title> (2003)

Tracking moving objects in video can be carried out by correlating a template containing object pixels of the current frame. This approach may produce erronous results under noise. We determine a set of significant pixels on the object by analyzing the wavelet transform of the template and correlate only these pixels with the current frame to determine the position of the object. These significant pixels are easily trackable features of the image and incrase the performance of the tracker.
Complete characterization of a spatiotemporal pulse shaper with two-dimensional Fourier transform spectral interferometry (2007)

Spatiotemporal pulse shaping is characterized with two-dimensional Fourier transform spectral interferometry. A deformable-mirror-based bidimensional pulse shaper is used to create simple spatiotemporal structures on a femtosecond pulse, structures that are directly calculated from the measured spatiospectral phases and intensities.
An Effective Tile Caching Mechanism of UAV Remote Sensing Map Based on Hilbert Coding Index (2019)

The Unmanned Aerial Vehicle (UAV) remote sensing system has become one of the most important tools for the acquisition of modern remote sensing data. The map generated by UAV remote sensing images is expected to be widely used in resource monitoring, post-disaster reconstruction and so on. Tile cache is an important way to speed up real-time loading of tile map. In order to accelerate the tile loading of UAV map, we take advantage of data locality principle and user behavior to build Hilbert coding index for each level in the tile pyramid. Then, we propose a neighborhood prefetching cache strategy, which is analyzed from the two dimensions of width and depth on the basis of Hilbert coding index. Compared with a simple strategy taking single tile as cache granularity, this caching strategy improves cache hit ratio and reduces average response time of tiles significantly. Meanwhile, Redis as the cache database, which not only supports the persistence of memory data, but also has the advantages of high development efficiency and strong scalability.
Control of Membrane Lipid Fluidity by Molecular Thermosensors (2004)

Bacteria can encounter a wide range of environments and must adapt to new conditions in order to survive. As the selective barrier between living cells and their environment, the plasma membrane plays a key role in cell viability. The barrier function of the cytoplasmic membrane is known to depend
Real-time investigation of individual silicon nanostructured electrodes for lithium-ion batteries (2013)

Silicon-based anode materials are an attractive candidate to replace today's widely-utilized graphitic electrodes for lithium-ion batteries because of their high gravimetric energy density (3572 mAh/g vs. 372 mAh/g for carbon) and relatively low working potential (~ 0.5V vs. Li/Li+). However, their commercial realization is still far away because of the structural instabilities associated with huge volume changes of ~300% during charge-discharge cycles. Recently, it has been proposed that silicon nanowires and other related one-dimensional nanostructures could be used as lithium storage materials with greatly enhanced storage capacities over that for graphite in the next generation of lithium-ion batteries. However, the studies to date have shown that the nanomaterials, while better, are still not good enough to withstand a large number of lithiation cycles, and moreover, there is little fundamental insight into the science of the improvements or the steps remaining before widespread adoption. This dissertation seeks to understand the basic structural properties and reaction kinetics of one dimensional silicon nanomaterials, including Si-C heterostructures during electrochemical lithiation/delithiation using in-situ transmission electron microscopy (TEM). I present my work in three parts. In part I, I lay out the importance of lithium-ion batteries and silicon-based anodes, followed by experimental techniques using in-situ TEM. In part II, I present results studied on three different nanostructures: Si nanowires (SiNWs), Si-C heterostructures and Si nanotubes (SiNTs). In SiNWs, we report an unexpected two-phase transformation and anisotropic volume expansion during lithiation. We also report an electrochemically-induced weld of ~200 MPa at the Si-Si interface. Next, studies on CNT@α-Si heterostructures with uniform and beaded-string structures with chemically tailored carbon-silicon interfaces are presented. In-situ TEM studies reveal that beaded-string CNT@ α-Si structures can accommodate massive volume changes during lithiation and delithiation without appreciable mechanical failure. Finally, results on lithiation-induced volume clamping effect of SiNTs with and without functional Ni coatings are discussed. In Part III, a conclusion and a brief outlook of the future work are outlined. The findings presented in this dissertation can thus provide important new insights in the design of high performance Si electrodes, laying a foundation for next-generation lithium ion batteries.
Experimental demonstration of four-terminal magnetic logic device with separate read- and write-paths (2014)

Magnetic logic has recently become an attractive candidate for future electronics. This paper describes the demonstration of a four-terminal spintronic device with distinct read- and write-paths (“mCell”). The mCell enables a non-volatile circuit technology (mLogic) with gain sufficient to drive fanout independent of CMOS [1]. Measured material properties and prototype device results are presented.
Diagnostic accuracy of p16<sup>INK4a</sup> immunohistochemistry in oropharyngeal squamous cell carcinomas: A systematic review and meta‐analysis (2016)

The accurate diagnosis of human papillomavirus (HPV) causality in oropharyngeal squamous cell carcinomas (OPSCC) is likely to influence therapeutic decisions in affected patients in the near future. We conducted a systematic review and meta-analysis to determine the diagnostic accuracy of p16<sup>INK4a</sup> immunohistochemistry (IHC) to identify HPV-induced OPSCC. We identified all studies that performed p16<sup>INK4a</sup> IHC (index test) and HPV E6/E7 mRNA detection using an amplification-based method (gold standard to indicate a transforming relevance of HPV) in OPSCC. Testing with one or more comparator tests (HPV DNA PCR, HPV DNA in situ hybridization (ISH) and p16<sup>INK4a</sup> IHC/HPV DNA PCR combined testing) was an optional criterion for inclusion. Among 1,636 retrieved studies 24 fulfilled the inclusion criteria. The pooled sensitivity of p16<sup>INK4a</sup> IHC, HPV DNA PCR, HPV DNA ISH and p16<sup>INK4a</sup> IHC/HPV DNA PCR combined testing was 94% (95%-confidence interval (CI) 91-97%), 98% (CI 94-100%), 85% (CI 76-92%) and 93% (CI 87-97%), respectively. The pooled specificity was 83% (CI 78-88%), 84% (CI 74-92%), 88% (CI 78-96%) and 96% (CI 89-100%), respectively. p16<sup>INK4a</sup> IHC/HPV DNA PCR combined testing was as sensitive as either p16<sup>INK4a</sup> IHC or HPV DNA PCR alone but significantly more specific than either separate test. In conclusion, p16<sup>INK4a</sup> IHC is highly sensitive but moderately specific to diagnose HPV-transformed OPSCC when used as a single test. Combined p16<sup>INK4a</sup> IHC and HPV DNA PCR testing significantly enhances specificity while maintaining high sensitivity. This diagnostic test combination thus represents an attractive testing strategy for the reliable diagnosis of HPV-induced OPSCC in the clinical setting and may constitute an inclusion criterion for future therapeutic trials.
Size Estimation of Cloud Migration Projects with Cloud Migration Point (CMP) (2011)

One major obstacle to enterprise adoption of cloud technologies has been the lack of visibility into migration effort and cost. In this paper, we present a methodology, called Cloud Migration Point (CMP), for estimating the size of cloud migration projects, by recasting a well-known software size estimation model called Function Point (FP) into the context of cloud migration. We empirically evaluate our CMP model by performing a cross-validation on six different small-scale cloud migration projects and show that our size estimation model can be used as a reliable predictor for effort estimation. Furthermore, we prove that our CMP model satisfies the fundamental properties of a software size measure.
Birokrasi dan Kebijakan Publik di Indonesia (2019)

Isu “Birokrasi dan Kebijakan Publik di Indonesia” merupakan bagian dari isu tata kelola pemerintahan yang senantiasa menjadi diskursus yang menarik untuk dikaji. Keberadaan pemerintah sebagai pemegang otoritas tertinggi menjalankan peran krusial dalam membuat kebijakan publik. Edisi ini membahas beberapa isu yang berkaitan dengan kebijakan publik baik di tingkat nasional maupun lokal. Isu tentang Aksi Nasional Bela Negara menjadi isu yang cukup hangat beberapa waktu ini mengingat banyaknya kelompok yang dinilai tidak senafas dengan tujuan dan cita-cita bangsa. Tidak hanya itu, edisi ini juga akan meng highlight  beberapa temuan terkait upaya pemerintah menerapkan kebijakan untuk masyarakat, mulai dari berinovasi hingga menetapkan strategi untuk menjamin tercapainya tujuan kebijakan. Kajian tentang birokrasi dan kebijakan tidak hanya menyentuh sisi formal saja, akan tetapi akan masuk pada ranah politis dengan melihat relasi aktor dalam kebijakan publik, misalnya kebijakan tentang tata kelola konflik dan tata kelola kawasan. Beberapa uraian di atas menjadi point yang mendasari perlunya edisi ini. Birokrasi dan kebijakan publik merupakan suatu topik yang menarik, yang mana masih memerlukan kajian mendalam dari sisi administratif maupun politis.
Titelei/Inhaltsverzeichnis (2016)

Die 2010 unterzeichnete und 2011 in Kraft getretene Rahmenübereinkunft zur wirtschaftlichen Zusammenarbeit ("ECFA") stellt einen Meilenstein in den Beziehungen zwischen Taiwan und der Volksrepublik China dar. Es ermöglicht nicht nur die Liberalisierung verschiedener Wirtschaftssektoren, sondern auch weitergehende, institutionalisierte Verhandlungen zwischen den zwei seit 1949 separat regierten und sich gegenseitig nicht anerkennenden Ländern. Ausgehend davon befasst sich das Werk mit den Besonderheiten der ECFA sowie den auf ihrer Grundlage zustandegekommenen Nebenübereinkünften und nimmt dabei auf das weltweit fortgeschrittenste Integrationsmodell – die EU – Bezug. Darauf aufbauend wird der Schutz der kulturellen Vielfalt im Rahmen der Marktintegration thematisiert, ein Anliegen, das angesichts Taiwans Anspruch auf Eigenidentität von herausragender Bedeutung ist. Somit dürfte das Werk für Völkerrechtler, Europarechtler und Politik- bzw. Kulturwissenschaftler von Interesse sein.
A Novel Reaction Pathway in Olefin-Deuterium Exchange Reaction inside the Micropores of Rh(II) Dicarboxylate Polymer Complexes (2001)

Abstract Three dimensional microporous polymers of Rh fumarate or Rh terephthalate complexes exhibited high catalytic activity for hydrogen exchange and hydrogenation of olefins at 200 K. The hydrogen exchange reaction takes place only inside the nanopores of the complexes without complete scission of C–H bond of olefin molecule.
Distinguishing Enhancing From Nonenhancing Renal Lesions With Fast Kilovoltage-Switching Dual-Energy CT (2011)

Fast kilovoltage-switching dual-energy CT is highly specific in excluding enhancement and moderately to highly sensitive in detecting enhancement of renal lesions. Of the available dual-energy CT techniques, iodine density measurement using a threshold of 2 mg/cm(3) is most accurate in distinguishing enhancing from nonenhancing renal lesions.
Measurement of mechanical properties of materials in the micrometer range using electronic holographic moire´ (2003)

Measuring mechanical properties of specimens whose dimensions are in the range of micrometers poses a number of difficult and interesting problems. Currently there are a number of developments in this area, especially in connection with microelectromechanical systems (MEMS). Electronic holographic moire is an ideal tool for micromechanics studies. It does not require a modification of the surface by the introduction of a reference grating. This is of particular value when placing a reference grating becomes a difficult task. Traditional electronic holographic moire presents some difficult problems when large magnifications are needed and rigid body motion causes the loss of the correlation fringes. We present developments that solve these problems and extend the application of the technique to micromechanics.
Identifying Canadian mosquito species through DNA barcodes (2006)

A short fragment of mt DNA from the cytochrome c oxidase 1 (CO1) region was used to provide the first CO1 barcodes for 37 species of Canadian mosquitoes (Diptera: Culicidae) from the provinces Ontario and New Brunswick. Sequence variation was analysed in a 617-bp fragment from the 5' end of the CO1 region. Sequences of each mosquito species formed barcode clusters with tight cohesion that were usually clearly distinct from those of allied species. CO1 sequence divergences were, on average, nearly 20 times higher for congeneric species than for members of a species; divergences between congeneric species averaged 10.4% (range 0.2-17.2%), whereas those for conspecific individuals averaged 0.5% (range 0.0-3.9%).
<i>In Vivo</i> Comparison of CHX-DTPA Ligand Isomers in Athymic Mice Bearing Carcinoma Xenografts (1999)

Monoclonal antibodies (MAbs) labeled with radiometallonuclides via metal chelators are being investigated in the laboratory for use in clinical trials. The biodistribution of 111In- and 88Y-labeled antibody (MAb B72.3) using two isomeric forms (CHX-A and CHX-B) of the 2-(p-isothiocyanatobenzyl)-cyclohexyl-DTPA was compared in athymic mice bearing LS-174T tumors, human colon carcinoma xenografts. CHX-(A or B)-125I-DTPA-B72.3 was co-injected in all athymic mice to assess if the chelate conjugation altered the properties of MAb B72.3. In vitro studies demonstrated maintenance of integrity and immunoreactivity for both radioimmunoconjugates. The in vivo analysis, however, indicated major differences between the two isomer forms. In fact, the 88Y-CHX-A-DTPA radioimmunoconjugate demonstrated over the 7-day study period, a more efficient and stable tumor localization as well as a slower blood clearance rate than the CHX-B-DTPA chelate conjugate, suggesting a greater in vivo stability. Differences were also evident in critical normal organ uptake: no significant increase in liver- and spleen- or bone-to-blood ratios was observed when the CHX-A-DTPA chelate was labeled with indium or yttrium. The results described here demonstrate that the CHX-A-DTPA chelate conjugate can be considered more suitable than the CHX-B-DTPA isomer form when radiometallonuclides are coupled to an MAb.
The von Hippel–Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal (1998)

The inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene predisposes affected individuals to the human VHL cancer syndrome and is associated with sporadic renal cell carcinomas (RCC) and brain hemangioblastomas. VHL-negative 786-0 RCC cells are tumorigenic in nude mice which is suppressed by the reintroduction of VHL. Remarkably, this occurs without affecting the growth rate and cell cycle profile of these cells in culture. The 786-0 cell line, like many cancer cells, fails to exit the cell cycle upon serum withdrawal. Here, it is shown that reintroduction of the wild-type VHL gene restores the ability of VHL-negative RCC cancer cells to exit the cell cycle and enter G0/quiescence in low serum. Both VHL-positive and VHL-negative RCC cells exit the cell cycle by contact inhibition. The cyclin-dependent kinase inhibitor, p27, accumulates upon serum withdrawal, only in the presence of VHL, as a result of the stabilization of the protein. We propose that the loss of wild-type VHL gene results in a specific cellular defect in serum-dependent growth control, which may initiate tumor formation. This is corrected by the reintroduction of wild-type VHL, implicating VHL as the first tumor suppressor involved in the regulation of cell cycle exit, which is consistent with its gatekeeper function in the kidney.
Reduction of the mutual coupling between two planar inverted-F antennas working in close radiocommunication standards (2005)

This paper presents a solution to reduce the mutual coupling between two planar inverted-F antennas (PIFA's) working in close radiocommunication standards: DCS1800 (1710-1880 MHz) and UMTS (1920-2170 MHz). These antennas are positioned on the corner of a limited ground plane whose size is representative of the printed circuit board (PCB) of a typical mobile phone. Three antennas are designed and several arrangements are numerically studied. Prototypes are then fabricated and measured to validate our proposed solution which consists in inserting a suspended line between the PIFA's to neutralize the electromagnetic coupling
Problèmes posés par l'utilisation des jauges de contraintes 'in vivo' (1976)

SCOPUS: NotDefined.j
Automatic electrode selection in unobtrusive capacitive ECG measurements (2012)

Due to the demographic change and increased cost pressure, contactless measurement methods such as capacitive ECG become more and more interesting in research and industry. As these electrodes shall be integrated in objects of daily life to unobtrusively monitor patients (e.g. a chair or a bed), one major problem arises: no medical expert attaches the electrodes and it is a priori not known to which electrodes the patient will have the best contact. Hence, several electrodes are usually integrated and this paper proposes a simple but robust method to automatically select the best coupled electrodes for the deduction of an ECG. It uses the driven right leg (DRL)-electrode to capacitively inject a high frequency voltage into the patient which is then capacitively received and analysed by each electrode. The electrodes with the largest high frequency signal are then used for the deduction of the ECG.
Amastin Peptide-Binding Antibodies as Biomarkers of Active Human Visceral Leishmaniasis (2006)

Amastin surface proteins belong to a large family of developmentally regulated proteins comprising up to 45 members that have recently been discovered in the genus Leishmania and are highly similar to the amastin proteins in Trypanosoma cruzi. All members of the amastin gene family contain a highly conserved 11-amino-acid (aa) signature at the N terminus, which is unique to the amastin proteins and to the Trypanosomatidae family. Recent studies have demonstrated that this region is highly protective in a mouse model. The goal of the present study was to evaluate the potential of the 50-aa N-terminal domain of amastin proteins harboring the conserved 11-aa amastin signature peptide as a relevant immune biomarker of cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). We report here the amastin-binding total immunoglobulins (IgG) and/or IgG subclasses in the sera of patients at different stages of CL (n=90) and VL (n=41). In CL cases, there is no significant difference in seroreactivities between active, recovered, and nonhealed cases. However, the amastin peptide-reactive antibodies were present at high titers in 19 of 20 sera collected from patients with active VL compared to sera from patients recovered from VL and asymptomatic cases of VL. These data suggest that the amastin signature peptide could represent a relevant biomarker for the serodiagnosis of VL and, most importantly, that it could permit differentiation among the different stages of the disease.
Polarization Independent Adiabatic 3-dB Coupler for Silicon-on-Insulator (2017)

We demonstrate a polarization independent adiabatic 3-dB coupler for the silicon-on-insulator platform, with a measured bandwidth of 100 nm and power splitting ratios of 3 ± 0.7dB for both the transverse electric and transverse magnetic modes.