gebhart/patrepeval huggingface dataset:
An introduction to mass spectrometry applications in biological research (2004)

Mass spectrometry involves the measurement of the mass-to-charge ratio of ions. It has become an essential analytical tool in biological research and can be used to characterize a wide variety of biomolecules such as sugars, proteins, and oligonucleotides. In this review, a brief history of mass spectrometry is discussed, and the basic principles of the technology are introduced. A summary of some current applications is provided, as are examples of recently published research. The current methods used to identify, quantify, and characterize proteins and peptides are then reviewed. The range of applications of mass spectrometry is considerable and only promises to grow as the technology continues to improve.
A novel control strategy for high-frequency AC-link AC/AC direct converter based on virtual converter system (2005)

This paper proposes a simple control strategy for a high-frequency AC-link AC/AC direct converter. The proposed control strategy is based on the virtual converter system that consists of a PWM rectifier part, a high-frequency AC-link part and an inverter part. The proposed method realizes wide control range, high performances and low snubber loss. The validity of the proposed method is confirmed through the simulation and experimental results
The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion (2011)

Enterochromaffin (EC) cells of the diffuse neuroendocrine cell system secrete serotonin (5-HT) with activation of gut motility, secretion, and pain. These cells express adenosine (ADORA) receptors and are considered to function as mechanosensors. Physiological pathways mediating mechanosensitivity and adenosine responsiveness remain to be fully elucidated, as do their roles in inflammatory bowel disease (IBD) and neoplasia. Pure (98-99%) FACS-sorted normal and IBD human EC cells and neoplastic EC cells (KRJ-I) were studied. IBD-EC cells and KRJ-I overexpressed ADORA2B. NECA, a general ADORA receptor agonist, stimulated, whereas the A2B receptor antagonist MRS1754 inhibited, 5-HT release (EC50 = 1.8 × 10-6 M; IC50 = 3.7 × 10-8 M), which was associated with corresponding alterations in intracellular cAMP levels and pCREB (Ser133). Mechanical stimulation using a rhythmic flex model induced transcription and activation of Tph1 (tryptophan hydroxylase) and VMAT₁ (vesicular monoamine transporter 1) and the release of 5-HT, which could be inhibited by MRS1754 and amplified by NECA. Secretion was also inhibited by H-89 (PKA inhibitor) while Tph1 and VMAT₁ transcription was regulated by PKA/MAPK and PI₃K-mediated signaling. Normal and IBD-EC cells also responded to NECA and mechanical stimulation with PKA activation, cAMP production, and 5-HT release, effects reversible by MRS1754. EC cells express stimulatory ADORA2B, and rhythmic stretch induces A2B activation, PKA/MAPK/IP3-dependent transcription, and PKA-dependent secretion of 5-HT synthesis and secretion. Receptor expression is amplified in IBD and neoplasia, and 5-HT release is increased. Determination of factors that regulate EC cell function are necessary for understanding its role as a mechanosensory cell and to facilitate the development of agents that can selectively target cell function in EC cell-associated disease.
Radio Interface Protocols (2010)

The protocol layers above the physical layer are called the data link layer and the network Layer. In the UTRA FDD radio interface, layer 2 is split into sublayers. In the control plane, layer 2 contains two sublayers: the Medium Access Control (MAC) protocol and the Radio Link Control (RLC) protocol. This chapter describes the general radio interface protocol architecture. For each protocol, it describes the logical architecture and main functions. The chapter explains the logical channels and mapping between logical channels and transport channels. For MAC and RLC, it defines an example layer model to describe what happens to a data packet passing through these protocols. The chapter describes the Radio Resource Control (RRC) service states together with the main (RRC) functions and signaling procedures. Then, it is concluded by an introduction to the early User Equipment (UE) handling principles and enhancements for the call set-up time reduction. Controlled Vocabulary Terms access protocols; media access protocol; open systems
Rapid Manganese Removal from Mine Waters Using an Aerated Packed‐Bed Bioreactor (2005)

In the UK, the Environmental Quality Standard for manganese has recently been lowered to 30 microg/L (annual average), which is less than the UK Drinking Water Inspectorate's Maximum Permitted Concentration Value (50 microg/L). Current passive treatment systems for manganese removal operate as open-air gravel-bed filters, designed to maximize either influent light and/or dissolved oxygen. This requires large areas of land. A novel enhanced bioremediation treatment system for manganese removal has been developed that consists of a passively aerated subsurface gravel bed. The provision of air at depth and the use of catalytic substrates help overcome the slow kinetics usually associated with manganese oxidation. With a residence time of only 8 h and an influent manganese concentration of approximately 20 mg/L, >95% of the manganese was removed. The treatment system also operates successfully at temperatures as low as 4 degrees C and in total darkness. These observations have positive implications for manganese treatment using this technique in both colder climates and where large areas of land are unavailable. Furthermore, as the operation of this passive treatment system continually generates fresh manganese oxyhydroxide, which is a powerful sorbent for most pollutant metals, it potentially has major ancillary benefits as a removal process for other metals, such as zinc.
Sensor-net for Monitoring Vital Parameters of Vehicle Drivers (2007)

Improving the safety of the traffic is a social interest. Accidents are not only caused by poor technical conditions of the vehicles, but also by tired, indisposed, .
A Novel Method of Detecting Calcifications from Mammogram Images Based on Wavelet and Sobel Detector (2006)

Mammography is the most widely used and the most efficient method for detection of breast cancer. In which, calcifications are the most important signs of breast cancers. In order to help the radiologist read the mammograms more efficiently, detection of calcifications becomes a significant problem for the computer-aid diagnosis. A novel method of detecting calcifications from mammogram images based on wavelet transformation and Sobel detector, is introduced in this paper. A wavelet based image enhancement technique and the Sobel gradient operator are used consequently, to distinguish the calcifications from the breast tissues
Increased metabolizing activities of the tricarboxylic acid cycle and decreased drug metabolism in hepatocellular carcinoma (2002)

The aim of this study was to determine the metabolizing activities in the liver of patients with hepatocellular carcinoma (HCC). Thin-layer chromatography autoradioluminography was used to measure metabolizing activities. Succinate-producing activity (SPA) was used as an indicator of metabolizing activity of the tricarboxylic acid (TCA) cycle in mitochondria, and diazepam-N-demethylating activity (DZ-DA), diazepam-3-hydroxylating activity (DZ-HA) and tolbutamide-methyl-hydroxylating activity (TB-HA) as indicators of drug metabolizing activities by P-450. SPA and drug-metabolizing activity of HepG2 cells were examined to compare with those of human liver specimens. Liver biopsy specimens of 30 patients and surgical specimens of eight patients with HCC were studied. SPA of HepG2 cells was as high as that of human tumor tissue, and DZ-DA, DZ-HA and TB-HA were undetectable in HepG2 cells. SPA and DZ-HA of non-tumor tissue in biopsy samples were significantly higher than those in resected liver specimens (P < 0.05). In biopsy specimens, SPA was significantly higher in tumor tissue than in non-tumor tissue (P < 0.05), and DZ-DA, DZ-HA and TB-HA were significantly lower in tumor tissue (P < 0.01). SPA was significantly higher in large tumors (>/=30 mm) than in small tumors <30 mm (P < 0.05), and TB-HA was significantly lower in large tumors than in small tumors (P < 0.01). DZ-DA and TB-HA significantly decreased with the progression of the tumor differentiation (P < 0.05). In conclusion, HCC has increased metabolizing activities of the TCA cycle and decreased drug-metabolizing activities.
Comparison of the Pre-service Elementary Teachers' Understandings of the Basic Concepts of Astronomy and Their Attitudes Toward Astronomy between Korea and Japan (2007)

이 논문에서는 한국과 일본의 초등 예비교사들이 가지고 있는 천문학 기초개념에 대한 이해 정도와 천문학에 대한 태도를 조사하여 비교하였다. 천문학 기초개념 및 지식은 1998년에 천문교육연구협의회(The Collaboration for Astronomy Education Research, CAER)에서 개발한 천문학진단검사지(Astronomy Diagnostic Test, ADT ver.2.0)의 21문항에서 한일 양국의 중등학교 교육과정을 고려하여 선정한 12개 문항을 양국의 언어로 번안하여 투입하였다. 천문학 기초개념 및 지식에 대한 검사문항의 신뢰도는 0.69이었다. 천문학 태도에 대한 검사는 제일릭 등(Zeilik et at., 1999)이 개발한 천문학태도조사지(the Survey of Attitudes Towards Astronomy, SATA)를 그대로 번역하여 사용하였다. 신뢰도는 0.87이었다. 조사 결과 천문학 기초개념에 대한 한국의 예비교사들의 정답률은 38%이었고 일본은 37%이었지만, 통계적으로 유의미한 차이는 없었다. 천문학에 대한 태도에서는 한국의 초등 예비교사가 일본보다 높았다. 특히 천문학에 대한 인지적 능력과 가치의 범주는 통계적으로 유의미한 차이가 있었다(p<.05). 이 연구를 통해 부가적으로, 한국과 일본의 초등 예비교사들의 가진 천문학 기초개념이 지식의 수준이 40%, 미만이었으며, 천문학에 대한 태도 점수가 미국의 대학생들에 비하여 상당히 낮다는 점을 발견할 수 있었다. This study investigated pre-service elementary teachers' understanding of the basic concepts of and their attitudes toward astronomy in Korea and Japan. The survey instrument called the Astronomy Diagnostic lest (ADT) that was developed by the Collaboration for Astronomy Education Research (CAER) in 1998 was used and modified to tailor to the two countries' contexts, including 12 items written in the two languages, Korean and Japanese. The attitudes toward astronomy were examined by the Survey of Attitudes toward Astronomy (SATA), which was developed by Zeilik et al. in 1999. Cronbach's alpha of this sample of the study was 0.69, while the reliability of SATA was 0.87. All the pre-service elementary teachers in both Korea and Japan showed a low-level understanding of the basic concepts of astronomy. 38% of Korean pre-service elementary teachers had correct answers to the questions regarding the basic conceptions of astronomy, while 37% of Japanese participants had correct answers to them. Although there was no statistically significant difference between Korean and Japanese pre-service elementary teachers, Korean teachers scored higher than Japanese participants in SATA. A significant difference, however, was revealed in the categories of cognitive competence and value of the attitudes toward astronomy (p <.05). In addition, it was found that both Korean and Japanese pre-service elementary teachers scored less than 40% about the basic concepts of astronomy and that they obtained lower scores than the US college students with regard to the attitudes toward astronomy.
A Historical Perspective on Hardware AI Inference, Charge-Based Computational Circuits and an 8 bit Charge-Based Multiply-Add Core in 16 nm FinFET CMOS (2019)

The second wave of AI is about statistical learning of low dimensional structures from high dimensional data. Inference is done using multilayer, data transforming networks using fixed point arithmetic with parameters that have limited precision (4-16 bits). In this paper we give a historical perspective on hardware AI inference deep Artificial Neural Networks (ANNs) or in short Deep Neural Networks (DNN) and deep learning. We review custom chip implementations of ANNs from thirty years ago and from the more recent publications in the last five years. With only few exceptions, hardware AI architectures are digital but we argue that if done right, i.e. in the charge domain, analog computation will have a role in future hardware AI systems. We make our discussion concrete by presenting the architecture, implementation and measurements from a mixedsignal, charge-based 8-bit analog multiplier for limited precision linear algebra in AI systems. Using a capacitor array, and charge redistribution, the architecture performs the multiplication operation in the charge domain at the thermal noise limit with near minimum energy dissipation. The charge redistribution multiplier core was fabricated in a 16 nm FinFET CMOS process, with measured energy 1.4 fJ for the analog multiplication operation. Compared to a conventional digital implementation synthesized and simulated in the same technology, the proposed design achieves the same performance at 37% less energy.
Bio‐Assembled Nanocomposites in Conch Shells Exhibit Giant Electret Hysteresis (2012)

Giant electric polarization (2000-4000 μC cm(-2)) is observed in natural conch shells. The nanolaminas and biopolymer layers of their unique hierarchical microstructures exhibit ferroelectret behavior and account for the observed polarization. Such huge polarization leads to extremely high pyroelectric coefficients, 2-3 orders of magnitude larger than those of conventional ferroelectric materials. The possibility of tailoring the giant polarization for various applications is considered.
Cell surface characteristics of some phage‐resistant strains of <i>Lactobacillus casei</i> (1987)

The cell surface characteristics of two types of PL‐1 phage‐resistant strains of Lactobacillus casei: K‐12, which does not permit adsorption of the phage; and YIT 9021, which permits phage adsorption but not genome injection, were compared with those of the parent strain. There were no differences in the electron microscopic features of the cell surface. However, both the phage‐resistant strains were more hydrophobic than the parent strain as judged by hydrocarbon affinity test. A colloid titration test showed that these mutant strains were less negatively charged than the parent one. They differed in the composition of the polysaccharide of their cell walls, which were all free from teichoic acids.
AUTONOM: system for computer translation of structural diagrams into IUPAC-compatible names. 2. Nomenclature of chains and rings (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAUTONOM: system for computer translation of structural diagrams into IUPAC-compatible names. 2. Nomenclature of chains and ringsL. Goebels, A. J. Lawson, and J. L. WisniewskiCite this: J. Chem. Inf. Comput. Sci. 1991, 31, 2, 216–225Publication Date (Print):May 1, 1991Publication History Published online1 May 2002Published inissue 1 May 1991https://pubs.acs.org/doi/10.1021/ci00002a007https://doi.org/10.1021/ci00002a007research-articleACS PublicationsRequest reuse permissionsArticle Views164Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Effects of commercial enzymes on the adhesion of a marine biofilm-forming bacterium (2007)

The antifouling potential of commercial hydrolases, four proteases, seven glycosidases and one lipase was evaluated on the adhesion of marine Pseudoalteromonas sp. D41. The experimental method, adapted to screen antifouling agents, was based on bacterial adhesion in natural sterile sea water in a microtiter plate and on total biomass quantification by the fluorescent dye DAPI (4[prime]6-diamidino-2-phenylindole). Savinase (subtilisin) was the most effective hydrolase in both the prevention of bacterial adhesion and the removal of adhered bacteria. However, some enzymatic preparations tested such as Amano protease were not only ineffective but also increased the number of adhered bacterial cells. Enumeration using epifluorescence microscopy of CTC (5-cyano-2,3-ditolyl tetrazolium chloride) and DAPI stained adhered D41 cells confirmed these observations. Overall, these results demonstrated that hydrolases could either prevent adhesion and remove adhered bacterial cells effectively, or conversely increase bacterial adhesion, depending on enzymatic concentrations and the type of enzymes tested.
Elevated speaker projection for digital home entertainment system (2001)

This paper presents a novel processing technique to enhance the sound images when playback over elevated loudspeakers for both two-speaker and multiple-speaker configuration. This is achieved by specially designed inverse filter together with HRTF filtering.
Regulation of bovine glomerular endothelial cell growth in vitro (1989)

To enable the study of glomerular endothelial cell functions and interactions with other glomerular cells, bovine glomerular capillary endothelial cells were established in culture. Selective media were used to facilitate endothelial cell proliferation and to suppress glomerular mesangial cell growth. Glomerular endothelial cells were separated from other cell types by fluorescence-activated cell sorting or, alternatively, by cloning. Glomerular endothelial cells expressed angiotensin I-converting enzyme and factor VIII activity and acetylated LDL uptake, properties generally held to be specific for endothelial cells. Proliferation of subconfluent glomerular endothelial cells was stimulated by basic fibroblast growth factor and, in the presence of heparin sodium, by acidic fibroblast growth factor. Platelet-derived growth factor was without effect on glomerular endothelial cell proliferation. Coculture with mesangial cells markedly inhibited proliferation of subconfluent glomerular endothelial cells. By contrast, medium conditioned by confluent glomerular endothelial cells markedly enhanced proliferation of subconfluent glomerular endothelial cells. These findings suggest that glomerular endothelial cell growth is under autocrine and paracrine control.
An integrated approach for early forest fire detection and verification using optical smoke, gas and microwave sensors (2010)

In 2008 the research project "International Forest Fire Fighting" (iWBB) was funded by the Minister for Economic Affairs and Energy of the
Neuropeptide-Y Concentration in Microdissected Hypothalamic Regions and<i>in Vitro</i>Release from the Medial Basal Hypothalamus-Preoptic Area of Streptozotocin-Diabetic Rats with and without Insulin Substitution Therapy* (1990)

Experimental diabetes adversely affects hypothalamic control of gonadotropin secretion and sex behavior and induces hyperphagia accompanied by severe body weight loss. Neuropeptide-Y (NPY) stimulates pituitary gonadotropin release, inhibits sexual behavior, and stimulates robust feeding in rats by acting at different sites in the hypothalamus. Therefore, we tested the hypothesis that altered hypothalamic NPY neurosecretion may mediate the constellation of effects observed in streptozotocin-induced diabetic (STZ-D) rats. Adult male rats were made diabetic by a single injection of STZ (50 mg/kg). Five months later, in vitro NPY release from the hypothalamic fragment encompassing the medial basal hypothalamus and preoptic area and NPY concentrations in seven hypothalamic sites were assessed. Basal NPY release was not significantly changed after STZ treatment. However, in response to a 30-min pulse of KCl (45 mM), NPY release from the medial basal hypothalamus-preoptic area of STZ-D rats was significantly increased compared to that in age-matched controls. In the STZ-D rats, NPY concentrations in six of the seven microdissected nuclei, including those mediating control of pituitary gonadotropin, sexual, and feeding behaviors, were increased compared to control values. In an additional study similar increments in NPY concentrations in the hypothalamic sites were observed 6 months after STZ treatment. The effects of insulin on NPY levels in microdissected hypothalamic sites in STZ-treated and BB diabetic rats was next assessed. One group of rats was treated with STZ, and the other group of rats was additionally treated with insulin (6 U/kg.day) for 3 months after development of diabetes with STZ. Again, STZ treatment alone, even for 3 months, increased NPY levels in all seven nuclei, including the suprachiasmatic nuclei. Insulin therapy completely prevented the STZ-induced increments in NPY levels in all hypothalamic sites, and the blood glucose level was 233 +/- 22 mg/dl in insulin-treated STZ-D rats and 496 +/- 6 mg/dl in untreated STZ-D rats. Similarly, NPY concentrations in five of the seven nuclei were unchanged in spontaneously diabetic BB rats (blood glucose, 435 +/- 67 mg/dl) maintained on insulin (5-8 U/kg.day). These results demonstrate that STZ-D rats have a widespread increase in NPY levels in hypothalamic sites, and there is an increase in the evoked release of NPY from the hypothalamus.(ABSTRACT TRUNCATED AT 400 WORDS)
Expression of a functional barley sucrose‐fructan 6‐fructosyltransferase in the methylotrophic yeast <i>Pichia pastoris</i> (1998)

The cDNA encoding sucrose-fructan 6-fructosyltransferase (6-SFT) from barley (Hordeum vulgare) has been expressed in the methylotrophic yeast Pichia pastoris, using a translational fusion into vector pPICZ alphaC, containing the N-terminal signal sequence of Saccharomyces cerevisiae alpha-factor to allow entry into the secretory pathway. Transformed Pichia produced and secreted a functional 6-SFT which had characteristics similar to the barley enzyme, but had a pronounced additional 1-SST activity when incubated with sucrose.
Text analytics approach to extract course improvement suggestions from students’ feedback (2018)

In academic institutions, it is normal practice that at the end of each term, students are required to complete a questionnaire that is designed to gather students' perceptions of the instructor and their learning experience in the course. Students' feedback includes numerical answers to Likert scale questions and textual comments to open-ended questions. Within the textual comments given by the students are embedded suggestions. A suggestion can be explicit or implicit. Any suggestion provides useful pointers on how the instructor can further enhance the student learning experience. However, it is tedious to manually go through all the qualitative comments and extract the suggestions. In this paper, we provide an automated solution for extracting the explicit suggestions from the students' qualitative feedback comments. The implemented solution leverages existing text mining and data visualization techniques. It comprises three stages, namely data pre-processing, explicit suggestions extraction and visualization. We evaluated our solution using student feedback comments from seven undergraduate core courses taught at the School of Information Systems, Singapore Management University. We compared rule-based methods and statistical classifiers for extracting and summarizing the explicit suggestions. Based on our experiments, the decision tree (C5.0) works the best for extracting the suggestions from students' qualitative feedback.