gebhart/patrepeval huggingface dataset:
Reducing Unwanted Gains During the Cooling Season From a Heat Pipe Augmented Passive Solar Heating System (2012)

The heat pipe augmented solar heating system significantly reduces heating loads relative to other conventional passive space heating systems [1–3]. Yet unwanted thermal gains during the cooling season from passive solar systems increase cooling loads and, in extreme cases, may even increase overall space conditioning loads relative to a nonsolar building. The objective of this study was to compare the effectiveness of several design modifications and control strategies for the heat pipe wall to reduce unwanted gains. MATLAB was used to simulate four different unwanted gains reduction mechanisms: 1. shading to block beam radiation from striking the collector, 2. an opaque cover to block all radiation from striking the collector, 3. a mechanical valve in the adiabatic section to eliminate convective heat transfer through the heat pipe into the room, and 4. switching the elevations of the evaporator and condenser sections of the heat pipe to provide heat transfer out of the room during the cooling season. For each mechanism, three different control strategies were evaluated: 1. Seasonal control, for which the prescribed mechanism is deployed at the beginning and removed at the end of the cooling season, 2. ambient temperature-based control, for which the mechanism is deployed if the forecast for the next hour (based on TMY3 weather data) is greater than 65°F, and 3. room temperature-based control, for which the mechanism is deployed if auxiliary cooling was required for the previous hour. For the seasonal strategy, the months for which the unwanted gains reduction mechanism should be deployed to minimize overall space conditioning loads were estimated with a season determination ratio (SD), defined as the monthly ratio of unwanted gains to heating load. Results suggested that SD may be a ‘universal’ parameter that can be applied across a range of climates for quick assessment of its optimal cooling season. With TMY3 data for Louisville, KY, the heat pipe system performed best with ambient temperature-based control. The mechanical valve was the best single mechanism. While in many cases the combination of the valve with a cover or shading produced slightly better performance than the mechanical valve alone, these additional reductions were small. Switching elevations of the evaporator and condenser sections produced little cooling, because of the low thermal emittance of the absorber and low thermal transmittance of the cover, and for the Louisville climate, small diurnal temperature swings during the summer.
Memory and computation effective approaches for i-vector extraction (2012)

Tip design, energy settings, and the positioning of the laser tip below the canal entrance caused an improvement in cleaning performance of the LAI. However, the small R200T tip created significantly more procedural errors (irrigant extrusion) due to higher concentrated energy.
Direct Photoaffinity Labeling of the Kir6.2 Subunit of the ATP-sensitive K+ Channel by 8-Azido-ATP (1999)

ATP-sensitive potassium channels are under complex regulation by intracellular ATP and ADP. The potentiating effect of MgADP is conferred by the sulfonylurea receptor subunit of the channel, SUR, whereas the inhibitory effect of ATP appears to be mediated via the pore-forming subunit, Kir6.2. We determined whether ATP directly interacts with a binding site on the Kir6.2 subunit to mediate channel inhibition by analyzing binding of a photoaffinity analog of ATP (8-azido-[gamma-32P]ATP) to membranes from COS-7 cells transiently expressing Kir6.2. We demonstrate that Kir6.2 can be directly labeled by 8-azido-[gamma-32P]ATP but that the related subunit Kir4.1, which is not inhibited by ATP, is not labeled. Photoaffinity labeling of Kir6.2 is reduced by approximately 50% with 100 microM ATP. In addition, mutations in the NH2 terminus (R50G) and the COOH terminus (K185Q) of Kir6.2, which have both been shown to reduce the inhibitory effect of ATP upon Kir6.2 channel activity, reduced photoaffinity labeling by >50%. These results demonstrate that ATP binds directly to Kir6.2 and that both the NH2- and COOH-terminal intracellular domains may influence ATP binding.
Steroid Binding Activity Is Retained in a 16-kDa Fragment of the Steroid Binding Domain of Rat Glucocorticoid Receptors (1989)

The steroid binding domain of the rat glucocorticoid receptor is considered as extending from amino acids 550 to 795. However, such a synthetic protein (i.e. amino acids 547-795; Mr approximately 31,000) has been reported to show very little affinity for the potent synthetic glucocorticoid dexamethasone. We now disclose that digestion of steroid-free rat glucocorticoid receptors with low concentrations of trypsin yields a single species, of Mr = 16,000, that is specifically labeled by dexamethasone 21-mesylate. This 16-kDa fragment retains high affinity binding for [3H]dexamethasone that is only approximately 23-fold lower than that seen with the intact 98-kDa receptor. Analysis of the protease digestion patterns obtained both with trypsin and with lysylendopeptidase C allowed us to deduce the proteolytic cleavage maps of the receptor with these enzymes. From these protease maps, the sequence of the 16-kDa fragment was identified as being threonine 537 to arginine 673. These results show that glucocorticoid receptor fragments smaller than 34 kDa do bind steroids and that the amino acids Thr537-Arg673 constitute a core sequence for ligand binding within the larger steroid binding domain. The much slower kinetics in generating the 16-kDa fragment from affinity-labeled receptors suggests that steroid binding causes a conformation change in the receptor near the cleavage sites.
Multiplicative mismatched filters for sidelobe suppression in Barker codes (2008)

A mismatched filter, comprised of a matched filter in cascade with a parameterized multiplicative finite-duration impulse response (FIR) filter, is proposed. For a given mainlobe to sidelobe ratio, the proposed filter is longer than the length-optimal filters but uses fewer multipliers and adders. Results are shown for Barker codes of length 5, 7, 11, and 13 and extended to compound Barker codes.
Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals (2005)

The development of a vaccine would provide an important new tool for the control of human hookworm infection. On the basis of successful vaccination of laboratory animals with living irradiated, third-stage hookworm larvae (L3), we examined the antibody responses of individuals from hookworm endemic areas of Brazil and China against the most abundant L3 secreted antigens, the ancylostoma secreted proteins, ASP-1 and ASP-2. Logistic regression was used to investigate the effects of antibody isotype responses to ASPs on the risk of an individual harboring heavy hookworm infection. A significant protective association was observed between increasing anti-ASP-2 IgE levels and the risk of heavy hookworm infection. To confirm that ASP-2 is a protective antigen, laboratory dogs were immunized with recombinant ASP-2 formulated with the GlaxoSmithKline Adjuvant, AS03. Sera obtained from the immunized dogs exhibited high geometric mean antibody titers, immunoprecipitated native ASP-2 from L3 extracts and localized the site of ASP-2 expression to the glandular esophagus and body channels exiting to the cuticle. The sera also exhibited an increased ability to inhibit migration of L3 through tissue in vitro relative to sera from AS03-injected controls. Upon L3 challenge, the ASP-2 vaccinated dogs exhibited significant reductions in fecal egg counts and intestinal hookworm burden. These findings provide strong support for the development of an effective recombinant vaccine against hookworm infection in humans.
Assessing placental function across gestation: a multi-institutional study of BOLD-MRI for the prediction of adverse pregnancy outcomes (2021)

Abstract The placenta is a remarkable organ that coordinates and regulates maternal-fetal interactions during pregnancy to optimize fetal development. A host of obstetric complications are associated with placental dysfunction, and existing methods for evaluating in vivo placental function fail to reliably detect at-risk pregnancies prior to maternal or fetal morbidity. Although routinely used as a monitoring tool, the predictive power of ultrasound for identifying compromised pregnancies is poor. Recent preclinical studies performed in our laboratory, using blood oxygen-level dependent magnetic resonance imaging (BOLD-MRI) in the pregnant nonhuman primate (NHP), established a strong correlation between placental T2* values and maternal-fetal oxygen transport. Here we extend this work to a large, longitudinal, two-site study of quantitative in vivo T2* mapping in human pregnancies across 11 to 38 weeks of gestation to characterize the evolution of placental oxygenation in uncomplicated pregnancies and to elucidate the relationship between aberrant placental T2* and adverse obstetric outcomes attributable to placental dysfunction. This methodology has high discriminatory power and strong potential diagnostic utility.
Color Conversions In The Transform Domain (2007)

A noval novel technique is described for high speed color conversions for JPEG-compressed images. The color conversion is processed in the transform domain instead of the traditional spatial domain. Only the input DC coefficients of the multiple color components are processed through the traditional table lookup to create output DC coefficients. Given each output color component's DC value, the linearity of its 63 AC coefficients is determined and their transform domain scaling functions are looked up in a 1-D table as a function of only the component output DC term. For n-dimensional input color space to m-dimensional output color space conversion, n component blocks create m output blocks. These blocks can be inverse DCTed to create spatial domain data or requantized and entropy encoded to create JPEG compressed data. Abort criteria also have been developed to determine when the traditional spatial domain interpolation needs to be done.
Transformation of restriction endonuclease phenotype in Streptococcus pneumoniae (1982)

The genetic basis of the unique restriction endonuclease DpnI, that cleaves only at a methylated sequence, 5'-GmeATC-3', and of the complementary endonuclease DpnII, which cleaves at the same sequence when it is not methylated, was investigated. Different strains of Streptococcus pneumoniae isolated from patients contained either DpnI (two isolates) or DpnII (six isolates). The latter strains also contained DNA methylated at the 5'-GATC-3' sequence. A restrictable bacteriophage, HB-3, was used to characterize the various strains and to select for transformants. One laboratory strain contained neither DpnI nor Dpn II. It was probably derived from a DpnI-containing strain, and its DNA was not methylated at 5'-GATC-3'. Cells of this strain were transformed to the DpnI restriction phenotype by DNA from a DpnI-containing strain and to the DpnII restriction phenotype by DNA from a DpnII-containing strain. Neither cross-transformation, that is, transformation to one phenotype by DNA from a strain of the other phenotype, nor spontaneous conversion was observed. Extracts of transformants to the new restriction phenotype were shown to contain the corresponding endonuclease.
Increased X-ray Visualization of Shape Memory Polymer Foams by Chemical Incorporation of Iodine Motifs (2017)

Shape memory polymers can be programmed into a secondary geometry and recovered to their primary geometry with the application of a controlled stimulus. Porous shape memory polymer foam scaffolds that respond to body temperature show particular promise for embolic medical applications. A limitation for the minimally invasive delivery of these materials is an inherent lack of X-ray contrast. In this work, a triiodobenzene containing a monomer was incorporated into a shape memory polymer foam material system to chemically impart X-ray visibility and increase material toughness. Composition and process changes enabled further control over material density and thermomechanical properties. The proposed material system demonstrates a wide range of tailorable functional properties for the design of embolic medical devices, including X-ray visibility, expansion rate, and porosity. Enhanced visualization of these materials can improve the acute performance of medical devices used to treat vascular malformations, and the material porosity provides a healing scaffold for durable occlusion.
Biological markers of oxidative stress: Applications to cardiovascular research and practice (2013)

Oxidative stress is a common mediator in pathogenicity of established cardiovascular risk factors. Furthermore, it likely mediates effects of emerging, less well-defined variables that contribute to residual risk not explained by traditional factors. Functional oxidative modifications of cellular proteins, both reversible and irreversible, are a causal step in cellular dysfunction. Identifying markers of oxidative stress has been the focus of many researchers as they have the potential to act as an "integrator" of a multitude of processes that drive cardiovascular pathobiology. One of the major challenges is the accurate quantification of reactive oxygen species with very short half-life. Redox-sensitive proteins with important cellular functions are confined to signalling microdomains in cardiovascular cells and are not readily available for quantification. A popular approach is the measurement of stable by-products modified under conditions of oxidative stress that have entered the circulation. However, these may not accurately reflect redox stress at the cell/tissue level. Many of these modifications are "functionally silent". Functional significance of the oxidative modifications enhances their validity as a proposed biological marker of cardiovascular disease, and is the strength of the redox cysteine modifications such as glutathionylation. We review selected biomarkers of oxidative stress that show promise in cardiovascular medicine, as well as new methodologies for high-throughput measurement in research and clinical settings. Although associated with disease severity, further studies are required to examine the utility of the most promising oxidative biomarkers to predict prognosis or response to treatment.
A middle ear implantable hearing device for controlled amplification of sound in the human: A preliminary report (1987)

Millions of people in the United States suffer from hearing impairment that is not benefited or poorly benefited by surgery or conventional hearing aids. Recently, we introduced an implantable Temporal Bone Stimulator (TBS) designed for those patients having a hearing loss due to external canal conditions; such as, external canal atresia or disease, inoperable ossicular problems, atelectasis or eustachian tube malfunction, and chronic open-cavity mastoid disease. This device requires relatively good cochlear function. However, the electromagnetic application of this device has led to the development of a new device we call the Implantable Hearing Device (IHD). This device stimulates, by an electromagnetic field, an independent electromagnetic sensitive prosthesis attached to the ossicular chain. This direct energy transfer to the ossicular chain provides a high degree of sound amplification and fidelity, thus providing benefit for those with various degrees of sensorineural hearing impairment. Preliminary disclosure of the device design, the animal experimental results, and the data from human testing will be given.
Strategies for blind transport format detection using cyclic redundancy check in UMTS WCDMA (2006)

Cyclic redundancy check (CRC) bits that are conventionally used for error detection have recently found a new application in UMTS WCDMA standard (specifically, "blind transport format detection") for message length detection of variable-length message communications. Co-worked with the inner convolutional code, it was demonstrated that the CRC bits can simultaneously detect the receiver-unaware length of a message block without much degradation in its error detection capability. In this work, we introduce two novel decoding strategies for joint decoding of the convolutional and the CRC code. Two previous strategies are also quoted for comparison. Simulation results on their error performance and computational complexity are given.
Advanced query processing in databases (2000)

As random access memory gets cheaper, it becomes increasingly affordable to build computers with large main memories. However, main memory data processing is not as simple as increasing the buffer pool size. An important issue is the cache behavior. Cache optimization differs from buffer optimization in a disk-based system. Indexing structures can reduce overall computation time without using too much space. In this thesis, I studied the cache behavior of several existing indexing structures in main memory. I designed and implemented two kinds of cache sensitive indexing structures, namely the CSS-Trees and the CSB+-Trees. Using pointer elimination techniques, the number of cache misses is reduced significantly in both indexing structures. As a result, searching these cache conscious indexing structures is much faster than existing tree-based indexes. Unlike CSS-Trees, CSB+-Trees support incremental updates and are useful to a larger number of applications. 
In this thesis, I will also describe the Columbia Main Memory Database System. The goal of the system is to prototype a main memory based decision support system that provides fast query processing by improving the cache behavior. The system uses cache conscious data layout to store tables in main memory, which increases the spatial locality during table scans. It also employs cache conscious data processing algorithms. In particular, it uses cache sensitive indexing structures to perform indexed nested loop joins. 
The second part of this thesis focuses on complex query processing and optimization. Complex queries are common in decision support systems. As part of this thesis, I have designed and implemented a new “invariant” technique that can evaluate arbitrary correlated queries efficiently. The technique enhances the execution engine so that it recognizes the part of the subquery that is uncorrelated and tries to cache and reuse the invariant result. The method also teaches a conventional query optimizer to understand the invariant feature and thus allows it to generate better plans. The technique has been incorporated into a commercial release of Sybase IQ. (Abstract shortened by UMI.)
1.3 μm InP/InGaAsP planar avalanche photodiodes (1981)

An InP/InGaAsP planar avalanche photodiode operating at a wavelength of 1.3 μm has been fabricated by using Be implantation and a difference of impurity concentrations between two n-InP epitaxial layers. A sufficient guard ring effect is demonstrated by a photoresponse, and an avalanche gain of 110 is obtained at an initial photocurrent of 0.35 μA.
Nonthrombogenic, Biodegradable Elastomeric Polyurethanes with Variable Sulfobetaine Content (2014)

For applications where degradable polymers are likely to have extended blood contact, it is often important for these materials to exhibit high levels of thromboresistance. This can be achieved with surface modification approaches, but such modifications may be transient with degradation. Alternatively, polymer design can be altered such that the bulk polymer is thromboresistant and this is maintained with degradation. Toward this end a series of biodegradable, elastic polyurethanes (PESBUUs) containing different zwitterionic sulfobetaine (SB) content were synthesized from a polycaprolactone-diol (PCL-diol):SB-diol mixture (100:0, 75:25, 50:50, 25:75 and 0:100) reacted with diisocyanatobutane and chain extended with putrescine. The chemical structure, tensile mechanical properties, thermal properties, hydrophilicity, biodegradability, fibrinogen adsorption and thrombogenicity of the resulting polymers was characterized. With increased SB content some weakening in tensile properties occurred in wet conditions and enzymatic degradation also decreased. However, at higher zwitterionic molar ratios (50% and 75%) wet tensile strength exceeded 15 MPa and breaking strain was >500%. Markedly reduced thrombotic deposition was observed both before and after substantial degradation for both of these PESBUUs and they could be processed by electrospinning into a vascular conduit format with appropriate compliance properties. The mechanical and degradation properties as well as the acute in vitro thrombogenicity assessment suggest that these tunable polyurethanes could provide options appropriate for use in blood contacting applications where a degradable, elastomeric component with enduring thromboresistance is desired.
Real-Time Scheduling and Control of Single-Arm Cluster Tools With Residency Time Constraint and Activity Time Variation by Using Resource-Oriented Petri Nets (2019)

In semiconductor manufacturing, when a wafer is processed, it requires unloading from its process module in a given time interval, otherwise it is scraped. This requirement is called wafer residency time constraints. Thus, it is crucial to schedule a cluster tool such that the wafer sojourn time in a process module is within a given time window to satisfy the wafer residency time constraints. Besides wafer residency time constraints, in a cluster tool, the activity time is subject to variation. The activity time variation can make a feasible schedule obtained under the assumption of deterministic activity times become infeasible. To solve this problem, it is important to reveal the wafer sojourn time fluctuations with bounded activity time variation. Such an issue is addressed in this chapter for single-arm cluster tools. A single-arm cluster tool is modeled by a resource-oriented Petri net to describe the wafer fabrication processes. Based on it, a real-time control policy is proposed such that it offsets the effect of the activity time variation as much as possible. Then, the wafer sojourn time delay in a process module is analyzed and analytical expressions are derived to calculate the upper bound. With the help of the real-time control policy and wafer sojourn time delay analysis results, schedulability conditions and scheduling algorithms for an off-line schedule are presented in this chapter. The schedulability conditions can be analytically checked. If schedulable, an off-line schedule can be analytically found. The off-line schedule together with the real-time control policy forms the real-time schedule for the system. It is optimal in terms of cycle time minimization. Examples are given to show the application of the proposed approach.
SCNN (2017)

Convolutional Neural Networks (CNNs) have emerged as a fundamental technology for machine learning. High performance and extreme energy efficiency are critical for deployments of CNNs, especially in mobile platforms such as autonomous vehicles, cameras, and electronic personal assistants. This paper introduces the Sparse CNN (SCNN) accelerator architecture, which improves performance and energy efficiency by exploiting the zero-valued weights that stem from network pruning during training and zero-valued activations that arise from the common ReLU operator. Specifically, SCNN employs a novel dataflow that enables maintaining the sparse weights and activations in a compressed encoding, which eliminates unnecessary data transfers and reduces storage requirements. Furthermore, the SCNN dataflow facilitates efficient delivery of those weights and activations to a multiplier array, where they are extensively reused; product accumulation is performed in a novel accumulator array. On contemporary neural networks, SCNN can improve both performance and energy by a factor of 2.7x and 2.3x, respectively, over a comparably provisioned dense CNN accelerator.