gebhart/patrepeval huggingface dataset:
Methylation and Messenger RNA Expression of <i>p15INK4b</i> but Not <i>p16INK4a</i> Are Independent Risk Factors for Ovarian Cancer (2005)

Our results suggest that epigenetic alterations in p15INK4b but not p16INK4a have an important role in ovarian carcinogenesis and that mechanisms other than methylation may exist to reduce gene expression of p15INK4b in ovarian cancer.
Design strategy for low-voltage SC circuits (1994)

Great care must be taken when using SC techniques from a low supply voltage to ensure proper switch operation. A new approach to solve this problem (called switched opamp) has been recently proposed and it is based on turning on and off the opamps in SC circuits. In the Letter a modified version of the switched opamp approach is proposed. This results in a considerable increase of the signal swing for a given supply voltage and in a substantial reduction of the minimum supply voltage required for proper circuit operation.
Distributed Authentication and Key Agreement Protocol for Ad hoc network (2007)

Ad hoc networks have developed rapidly due to its self-organization and stability, but its openness and mobility brings some problems in security. We present a trusted-computing based distributed virtual security zone (TC-DVSZ) model to ensure the security in ad hoc network with less computation and bandwidth. In the model, distributed authority (DA) has been introduced into the network to act as a CA in each cluster. To keep the DA trusted and reliable, we propose a trust based DA decision arithmetic. At the same time, we use ECC instead of RSA, and provide two level key agreement scheme, that decreases the cost of computation and increases the adaptability to various nodes with different computation capability. Finally, we prove that TC-DVSZ model is much more suitable for ad hoc network, because the model reduces the requirements for bandwidth, computation capacity and storage.
Analyses for Design of Drives and Disks for Dual-layer Phase Change Optical Disks (2003)

The signals obtained from dual-layer phase change optical disks were analyzed experimentally and theoretically putting emphases on reducing layer cross talk (LCT) and spherical aberration (SA). An analytical method to estimate LCT approximately was proposed, whose result turns out to be in good agreement with the experimental result. Based on this method and the analytical formula for SA, the solution for design of drives and disks for dual-layer optical disks is discussed for the system of blue laser light.
OPTIMIZATION OF MULTIFIBER LIGHT DELIVERY FOR THE PHOTODYNAMIC THERAPY OF LOCALIZED PROSTATE CANCER (1993)

The understanding of light distribution within the target organ is essential in ensuring efficacy and safety in photodynamic therapy (PDT). A computer simulator of light distribution in prostatic tissue was employed for optimizing dosimetry for PDT in localized prostatic cancer. The program was based on empirically determined light distributions and optical constants and an assumed fluence rate differential from fiber source to necrosis periphery. The diffusion theory approximation to the Boltzmann transport equation was the applicable formulation relevant to prostatic tissue, which has a high albedo with forward-scattering characteristics. Solving this equation of diffusive transfer for the appropriate fiber geometry yielded the energy fluence distributions for cleaved fiber and cylindrical diffuser light delivery. These distributions, confirmed by our measurements, show a 1/r and 1/square root of r dependency (r = distance from light source) of the fluence phi (r) for the cleaved fiber and diffuser, respectively. This manifests itself by the tighter spacing of energy fluence isodoses in the case of the cleaved fiber. It was predicted that for a typical PDT regime a single interstitially placed cleaved fiber would treat 0.05-0.72 cm3. Four parallel fibers improved the uniformity of light distribution and treatment volume, and an interfiber separation of 12 mm would be necessary to provide optimal overlap of PDT necrosis, treating 0.26-3.6 cm3. The cylindrical diffuser, however, could treat larger volumes, and it was predicted that four 3 cm long diffusers at an optimal separation of 25 mm would treat 25-88 cm3 of prostatic tissue.
2014: mais um ano para entrar para a história – inclusive na Educação (2014)

Fracassei em tudo o que tentei na vida. Tentei alfabetizar as criancas brasileiras, nao consegui. Tentei salvar os indios, nao consegui. Tentei fazer uma universidade seria e fracassei. Tentei fazer o Brasil desenvolver-se autonomamente e fracassei. Mas os fracassos sao minhas vitorias. Eu detestaria estar no lugar de quem me venceu. Darcy Ribeiro
Digital Image Processing Techniques for Object Detection From Complex Background Image (2012)

This paper discuss about the method or techniques on how to detect the mango from a mango tree. The techniques using are such as colour processing which are use as primary filtering to eliminate the unrelated colour or object in the image. Besides that, shape detection are been used where it will use the edge detection, Circular Hough Transform (CHT). This technique will determine the candidates of mango and find the circular pattern with the given radius within an image by collecting the maximum voting. The program should automatically detect the desire object and count the total number of it.
New IR semiconductors in the Si-Ge-Sn system (2005)

We will discuss CVD growth, characterization and properties of novel Ge/sub 1-z/Sn/sub z//Ge/sub 1-x-y/Si/sub x/Sn/sub y/ heterostructures on Si(100). The Ge/sub 1-x-y/Si/sub x/Sn/sub y/ system provides independent strain and bandgap engineering to achieve structures that may lead to novel photonic group-IV devices.
Determination of CO<sub>2</sub> Minimum Miscibility Pressure from Measured and Predicted Equilibrium Interfacial Tensions (2008)

Accurate determination of the minimum miscibility pressure (MMP) of a crude oil−CO2 system at the actual reservoir temperature is required in order to determine whether CO2 flooding is immiscible or miscible under the actual reservoir pressure. The objective of this study is to determine the MMPs of a crude oil−CO2 system from its measured and predicted equilibrium interfacial tension (IFT) versus equilibrium pressure data at a constant temperature. In the experiment, first, the CO2 solubilities in the crude oil are measured under four different equilibrium pressures. Second, the equilibrium IFTs of the crude oil−CO2 system are measured at 12 different equilibrium pressures and a constant temperature of T = 27 °C by applying the axisymmetric drop shape analysis (ADSA) technique for the pendant drop case. The detailed experimental results show that the CO2 solubility in the crude oil is increased almost linearly with the equilibrium pressure. It is also found that the measured crude oil−CO2 equilibrium IFT is reduced almost linearly with the equilibrium pressure as long as it is lower than a threshold pressure. The measured equilibrium IFT versus equilibrium pressure data are used to determine the MMP of the crude oil−CO2 system by applying the so-called vanishing interfacial tension (VIT) technique. In addition, the equilibrium IFT versus equilibrium pressure data of the crude oil−CO2 system are predicted by using the parachor model and linear gradient theory (LGT) model, respectively. The predicted equilibrium IFT data from each model are also used to determine the MMP of the same crude oil−CO2 system. Comparison of the MMPs determined from the two equilibrium IFT prediction models and that determined from the measured equilibrium IFTs shows that the LGT model is suitable for determining the MMP of the crude oil−CO2 system.
Synthesis and Liquid Membrane Transport Properties of Photolabile Molecular Clips Based on Dithiane-spiro-crown Ethers (2001)

[reaction: see text]. Synthesis of novel dithiane-spiro-crown ethers starting from 5,5-di(hydroxymethyl)-1,3-dithiane is developed. These compounds can be used as building blocks to assemble photolabile bis-crown ethers via addition to dicarbonyl-containing tethers, e.g., isophthalic aldehyde. It is found that unlike their mono-crown precursors such bidentate bis-crowns are capable of efficient liquid membrane transport of, for example, methyl viologen. The transport can be interrupted photochemically, providing a basis for developing smart light-responsive membranes.
Evaluation of Low-Contrast Detectability of Iterative Reconstruction across Multiple Institutions, CT Scanner Manufacturers, and Radiation Exposure Levels (2015)

The potential exists to reduce radiation dose without compromising low-contrast detectability by using iterative reconstruction instead of filtered back projection. There is substantial variability across vendor reconstruction algorithms.
Excited State Photophysics of Curcumin and its Modulation in Alkaline Non‐Aqueous Medium (2023)

Curcumin, a well-known medicinal pigment, has seen limited applications in biology despite having great potential as a therapeutic drug. Deprotonation is one of the possible ways to enhance solubility of curcumin in polar solvent. Here, we have explored the effect of deprotonation on the ultrafast dynamics of this biomolecule with the help of the time-resolved fluorescence spectroscopic measurements using the femtosecond fluorescence upconversion technique. The excited state photophysics of fully deprotonated curcumin significantly differs from that of neutral curcumin. We have observed that the completely deprotonated curcumin not only has higher quantum yield, but also higher excited state lifetime and slower solvation dynamics in comparison to neutral curcumin. We propose solvation dynamics and intramolecular charge transfer as the excited state processes associated with the radiative decay of the completely deprotonated molecule, while ruling out the possibility of excited state proton exchange or proton transfer. Our results are well supported by time-dependent density-functional theory calculations. Lastly, we have also demonstrated the possibility of modulating the ultrafast dynamics of fully deprotonated curcumin using non-aqueous alkaline binary solvent mixtures. We believe our results will provide significant physical insight towards unveiling the excited state dynamics of this molecule.
Smart distributed web crawler (2016)

Centralized crawlers are not adequate to spider meaningful and relevant portions of the Web. A crawler with good scalability and load balancing can bring growth to performance. As the size of web is growing, in order to complete the downloading of pages in fewer amounts of time and increase the coverage of crawlers it is necessary to distribute the crawling process. In this paper, we present client server architecture based smart distributed crawler for crawling web. In this architecture load between the crawlers is managed by server and each time a crawler is loaded, load is distributed to others by dynamically distributing the URLs. Focused crawlers makes efficient usage of network bandwidth and storage capacity, when distributed can enhance the performance.
Cobalt‐Mediated Switchable Catalysis for the One‐Pot Synthesis of Cyclic Polymers (2021)

A cobalt salen pentenoate complex [salen=(R,R)-N,N'-bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediamine] is rationally designed as the catalyst for the ring-opening copolymerization (ROCOP) of epoxides/anhydrides/CO<sub>2</sub> . Via migratory insertion of carbon monoxide (CO) into the Co-O bonds, the ROCOP-active species α-alkene-ω-O-Co<sup>III</sup> (salen) can be rapidly and quantitatively transformed into α-alkene-ω-O<sub>2</sub> C-Co<sup>III</sup> (salen) telechelic linear precursors. Upon dilution of reaction mixtures, the homolytic cleavage of Co-C bonds induced by visible light generates α-alkene acyl radicals that spontaneously undergo intramolecular radical addition to afford organocobalt-functionalized cyclic polyesters and CO<sub>2</sub> -based polycarbonates with excellent regioselectivity. The cyclic products can either react with radical scavengers to generate metal-free cyclic polymers or serve as photo-initiators for organometallic-mediated radical polymerization (OMRP) to produce tadpole-shaped copolymers.
Design optimization of discrete-time single-loop sigma-delta ADCs via nonideality and power analyses (2008)

Abstract:- A conventional Σ ∆ ADC design approach is a time consuming process and needs much trials and errors. An optimization algorithm for the discrete-time single-loop Σ ∆ ADCs design is proposed. Circuit nonideality models are derived in output noise power forms through a systematic circuit imperfection study. A power model is also presented in order to estimate relative power consumption. These models reveal that design parameter variation can potentially affect several noises and errors in different ways, and may change system power consumption. This design complexity is qualitatively summarized into a table. Model completeness allows us to propose an optimization algorithm to search globally for a design parameter combination which meets SNR requirement while minimizing power consumption. Our optimization algorithm is tested against two published design results, and is verified by behavior simulations. Comparisons with behavioral-simulation-based optimization approaches are also made.
A combined method to reduce motion artifact and power line interference for wearable healthcare systems (2010)

A combined method to reduce motion artifact (MA) and power line interference (PLI) for wearable healthcare system is introduced. The proposed method has a block for the reduction of MA using measured electrode-skin impedance as a reference signal and a block for the cancellation of PLI using mixed-signal feedback to relax the dynamic range requirements of components in the forward path. The measured electrode-skin impedance is used as a reference signal of an adaptive filter for reducing MA. The 60Hz notch frequency which has the same amplitude as PLI's is made digitally and uses feedback to the input stage to reduce PLI. This method was simulated using MATLAB/Simulink for high-level verification of the method's validity.
Rapid prototyping of electronic systems using FIPSOC (2003)

FIPSOC (field programmable system on chip) is a novel device shown to be suitable for rapid prototyping of electronic systems. After a description of its architecture and associated development tools, its distinguishing features are highlighted. In particular, integration of a microprocessor, programmable logic and configurable analog channels in the same chip provides a monolithic platform with capability to prototype complete systems. The integrated development software and chip capabilities offer low-cost emulation on the target device, hardware and software emulation, and integrated real-time probing. An application example of a DC motor controller illustrates the benefits in cost and development time that FIPSOC can provide.
Nonhydrolyzable Ubiquitin−Isopeptide Isosteres as Deubiquitinating Enzyme Probes. (2010)

We demonstrate that oxime ligation is an efficient, straightforward, and generally applicable strategy for generating nonhydrolyzable ubiquitin (Ub)-isopeptide isosteres. We synthesized nonhydrolyzable K48- and K63-linked Ub-isopeptide isosteres to investigate the selectivity of deubiquitinating enzymes for specific linkages employing surface plasmon resonance spectroscopy. The results indicate that deubiquitinating enzymes specifically recognize the local peptide sequence flanking Ub-branched lysine residues in target proteins. The described strategy allows the systematic investigation of sequence requirements for substrate selectivity of deubiquitinating enzymes.
Formation of Polyolefin‐<i>block</i>‐polystyrene Block Copolymers on Phenoxyimine Catalysts (2006)

Abstract Summary: PE‐ block ‐PS and P(E‐ co ‐P)‐ block ‐PS block copolymers were synthesised via sequential monomer addition during homogeneous polymerisation on various phenoxyimine catalysts. One phenoxyimine catalyst was tailored to produce high molecular weight block copolymers containing both, polyolefin and polystyrene segments. According to chromatographic analysis and TEM morphology studies, blends of block copolymers and PE homopolymers [or P(E‐ co ‐P), respectively] were formed. The direct olefin/styrene block copolymer synthesis on phenoxyimine catalysts represents an attractive, new one‐pot route to styrenic block copolymers which are commercially prepared by anionic styrene/diene block copolymerisation followed by hydrogenation. magnified image
Strong security starts with software development (2020)

While there is – rightly – a big focus on securing software that is already deployed, the reality is that many future vulnerabilities stem from the creation of that software. Insecure applications give hackers a back door. For instance, buffer overflows and code injection attacks can lead to compromised confidentiality of data, loss of service, damage to the systems of thousands of users, even – in the case of products containing embedded software, such as medical equipment or vehicles – risk to life. While we focus on securing software that is already deployed, the reality is that many future vulnerabilities stem from the creation of that software. Securing development is a tough challenge due to the increasing complexity of software, the volume of code, multiple contributors, distributed teams and the pressure to deliver to tight deadlines. Plus, developers traditionally have not been focused on security. That is changing with the emergence of DevSecOps, which focuses on implementing software security practices and tools at every stage of the lifecycle, explains Rod Cope of Perforce Software.
Remote Electrical Neuromodulation (REN) Relieves Acute Migraine: A Randomized, Double‐Blind, Placebo‐Controlled, Multicenter Trial (2019)

REN provides superior clinically meaningful relief of migraine pain and MBS compared to placebo, offering a safe and effective non-pharmacological alternative for acute migraine treatment.
Determination Of Microlocation Using the BLE Protocol, and Wireless Sensor Networks (2018)

This work deals with the determination of the location of an object with the help of an identification tag using wireless sensor networks. This uses an array of sensors distributed in the path. When the object with identification tag passes through the path, the sensors calculate the approximate distance from each of them with the help of a series of Received Signal Strength Indicator (RSSI) values. The data is collected and is displayed on a user interface provided. Bluetooth Low Energy (BLE) protocol is used in the wireless sensor network. The RSSI values are mapped to corresponding distances by an initial training and this data is used for estimation of the distance. Path loss exponent and curve fitting methods are proposed for estimation of distance from the initial training data. Further, an error reduction method is also proposed for improving the accuracy of the estimation.
Runx1/AML-1 Ranks as a Master Regulator of Adult Hematopoiesis (2004)

Runx1 (AML-1) is a critical gene involved in human leukemogenesis, originally identified at the 21q22 breakpoint of the leukemic translocations of t(8;21)(q21;q22), and is thought to be involved in as much as 25% of human leukemia. It encodes a transcription factor that has close homology to a Drosophila protein, runt, and is found to play essential roles in regulation of hematopoietic systems. Really a gene disruption experiment unequivocally shows that Runx1 is absolutely required for the establishment of definitive or adult-type hematopoiesis. Moreover, accumulated evidence from a number of in vitro studies and findings in patients with familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML) strongly suggests that it also commits to the control of hematopoietic system in adult life, although the in depth analysis of its roles in adult hematopoiesis has been largely hampered by premature lethality of Runx1-null animals. Recently we have developed conditional knockout mice in which Runx1 is disrupted specifically in hematopoietic compartments after birth and dissected its roles in adult hematopoiesis. Notably, in these mice, maturation of megakaryocytes and development of both T and B lymphocytes were severely impaired, whereas hematopoietic progenitors were maintained or even expanded with apparently normal myeloid and erythroid differentiation in the periphery and bone marrow. Our findings clearly demonstrated differential requirement of Runx1 in stem cell development and in its maintenance together with multi-modal functions of this transcription factor that are critically required for maturation of megakaryocytes and lymphocyte development, also providing a novel insight into how deeply amd meticulously Runx1 is involved in regulation of mammalian hematopoiesis.
Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study. (1997)

Leukemic cells of the pro-TL maturation stage identify a small subgroup of T-lineage ALL patients who have a significantly worse EFS outcome than patients whose cells are of a more mature stage of development.
CO2/N2 Gas Separation Using Pebax/ZIF-7—PSf Composite Membranes (2021)

In this study, we mixed the zeolitic imidazolate framework-7 (ZIF-7) with poly(ether-b-amide)<sup>®</sup> 2533 (Pebax-2533) and used it as a selective layer for a composite membrane. We prepared the composite membrane's substrate using polysulfone (PSf), adjusted its pore size using polyethylene glycol (PEG), and applied polydimethylsiloxane (PDMS) to the gutter layer and the coating layer. Then, we investigated the membrane's properties of gases by penetrating a single gas (N<sub>2</sub>, CO<sub>2</sub>) into the membrane. We identified the peaks and geometry of ZIF-7 to determine if it had been successfully synthesized. We confirmed that ZIF-7 had a BET surface area of 303 m<sup>2</sup>/g, a significantly high Langmuir surface area of 511 m<sup>2</sup>/g, and a high CO<sub>2</sub>/N<sub>2</sub> adsorption selectivity of approximately 50. Considering the gas permeation, with ZIF-7 mixed into Pebax-2533, N<sub>2</sub> permeation decreased from 2.68 GPU in a pure membrane to 0.43 GPU in the membrane with ZIF-7 25 wt%. CO<sub>2</sub> permeation increased from 18.43 GPU in the pure membrane to 26.22 GPU in the ZIF-7 35 wt%. The CO<sub>2</sub>/N<sub>2</sub> ideal selectivity increased from 6.88 in the pure membrane to 50.43 in the ZIF-7 25 wt%. Among the membranes, Pebax-2533/ZIF-7 25 wt% showed the highest permeation properties and the characteristics of CO<sub>2</sub>-friendly ZIF-7.
Genome-Wide Identification of Targets and Function of Individual MicroRNAs in Mouse Embryonic Stem Cells (2010)

Mouse Embryonic Stem (ES) cells express a unique set of microRNAs (miRNAs), the miR-290-295 cluster. To elucidate the role of these miRNAs and how they integrate into the ES cell regulatory network requires identification of their direct regulatory targets. The difficulty, however, arises from the limited complementarity of metazoan miRNAs to their targets, with the interaction requiring as few as six nucleotides of the miRNA seed sequence. To identify miR-294 targets, we used Dicer1-null ES cells, which lack all endogenous mature miRNAs, and introduced just miR-294 into these ES cells. We then employed two approaches to discover miR-294 targets in mouse ES cells: transcriptome profiling using microarrays and a biochemical approach to isolate mRNA targets associated with the Argonaute2 (Ago2) protein of the RISC (RNA Induced Silencing Complex) effector, followed by RNA-sequencing. In the absence of Dicer1, the RISC complexes are largely devoid of mature miRNAs and should therefore contain only transfected miR-294 and its base-paired targets. Our data suggest that miR-294 may promote pluripotency by regulating a subset of c-Myc target genes and upregulating pluripotency-associated genes such as Lin28.