gebhart/patrepeval huggingface dataset:
Mixed nicotinic and muscarinic features of cholinergic receptor coupled to secretion in bovine chromaffin cells. (1991)

Acetylcholine evokes release from cultured bovine chromaffin cells by a mechanism that is believed to be classically nicotinic. However, we found that the full muscarinic agonist oxotremorine-M (Oxo-M) induced a robust catecholamine (CA) secretion. By contrast, muscarine, pilocarpine, bethanechol, and McN-A-343 did not elicit any secretory response. Desensitization of the response to nicotine by Oxo-M and desensitization of the response to Oxo-M by nicotine suggest that both nicotine and Oxo-M were acting at the same receptor. Additional experiments supporting this conclusion show that nicotine-induced secretion and Oxo-M-induced secretion were similarly blocked by various muscarinic and nicotinic antagonists. Moreover, secretion induced by nicotine and Oxo-M were Ca2+ dependent, and both agonists induced 45Ca2+ uptake. Equilibrium binding studies showed that [3H]Oxo-M bound to chromaffin cell membranes with a Kd value of 3.08 x 10(-8) M and a Hill coefficient of 1.00, suggesting one binding site for this ligand. Nicotine inhibited Oxo-M binding in a noncompetitive manner, suggesting that both ligands bind at two different sites on the same receptor. We propose that the receptor on bovine chromaffin cells that is coupled to secretion represents an unusual cholinergic receptor that has both nicotinic and muscarinic features.
Modified silicas for clean technology (2000)

A wide variety of novel materials can be prepared through the chemical modification of silica gels with organic and inorganic functionalities. In addition to their use in chromatographic separations, they have been increasingly used as catalysts in liquid phase organic reactions. It is the application of these materials as viable, more environmentally friendly, alternatives to traditional homogeneous catalysts that forms the main body of this review. Their use as efficient materials for the selective pre-concentration of trace metals from aqueous systems is also discussed.
Demonstration of Protection of a Superconducting Qubit from Energy Decay (2018)

Long-lived transitions occur naturally in atomic systems due to the abundance of selection rules inhibiting spontaneous emission. By contrast, transitions of superconducting artificial atoms typically have large dipoles, and hence their lifetimes are determined by the dissipative environment of a macroscopic electrical circuit. We designed a multilevel fluxonium artificial atom such that the qubit's transition dipole can be exponentially suppressed by flux tuning, while it continues to dispersively interact with a cavity mode by virtual transitions to the noncomputational states. Remarkably, energy decay time T_{1} grew by 2 orders of magnitude, proportionally to the inverse square of the transition dipole, and exceeded the benchmark value of T_{1}>2 ms (quality factor Q_{1}>4×10^{7}) without showing signs of saturation. The dephasing time was limited by the first-order coupling to flux noise to about 4 μs. Our circuit validated the general principle of hardware-level protection against bit-flip errors and can be upgraded to the 0-π circuit [P. Brooks, A. Kitaev, and J. Preskill, Phys. Rev. A 87, 052306 (2013)PLRAAN1050-294710.1103/PhysRevA.87.052306], adding protection against dephasing and certain gate errors.
Speaker Anonymization with Distribution-Preserving X-Vector Generation for the VoicePrivacy Challenge 2020 (2020)

In this paper, we present a Distribution-Preserving Voice Anonymization technique, as our submission to the VoicePrivacy Challenge 2020. We observe that the challenge baseline system generates fake X-vectors which are very similar to each other, significantly more so than those extracted from organic speakers. This difference arises from averaging many X-vectors from a pool of speakers in the anonymization process, causing a loss of information. We propose a new method to generate fake X-vectors which overcomes these limitations by preserving the distributional properties of X-vectors and their intra-similarity. We use population data to learn the properties of the X-vector space, before fitting a generative model which we use to sample fake X-vectors. We show how this approach generates X-vectors that more closely follow the expected intra-similarity distribution of organic speaker X-vectors. Our method can be easily integrated with others as the anonymization component of the system and removes the need to distribute a pool of speakers to use during the anonymization. Our approach leads to an increase in EER of up to $19.4\%$ in males and $11.1\%$ in females in scenarios where enrollment and trial utterances are anonymized versus the baseline solution, demonstrating the diversity of our generated voices.
Isolation and Primary Structure of a Methionine- and Cystine-rich Seed Protein of<i>Cannabis sativa</i> (1998)

A 10-kDa protein was isolated from resting seeds of hemp (Cannabis sativa) by buffer extraction, gel filtration, ion-exchange chromatography, and reversed-phase high-pressure liquid chromatography. The protein did not inhibit bovine trypsin. It consisted of subunits composed of 27 and 61 residues and was held together by two disulfide bonds. The complete amino acid sequence was identified by protein analysis, and had 20 mole% of amino acids containing sulfur. The protein was most similar to a methionine-rich protein of Brazil nut (Bertholletia excelsa) and to Mabinlin IV, a sweetness-inducing protein of Capparis masaikai. The high methionine content and the absence of trypsin inhibitory activity suggested that the seed protein can be used to improve the nutritional quality of plant food-stuffs.
Non‐genomic effects of ginsenoside‐Re in endothelial cells via glucocorticoid receptor (2007)

We demonstrated that ginsenoside-Re (Re), a pharmacological active component of ginseng, is a functional ligand of glucocorticoid receptor (GR) using competitive ligand-binding assay (IC(50)=156.6 nM; K(d)=49.7 nM) and reporter gene assay. Treatment with Re (1 microM) raises intracellular Ca(2+) ([Ca(2+)](i)) and nitric oxide (NO) levels in human umbilical vein endothelial cells as measured using fura-2 and 4-amino-5-methylamino-2',7'-difluorofluorescein diacetate, respectively. Western blot analysis shows that Re increased phosphorylation of endothelial nitric oxide synthase. These effects were abolished by GR antagonist RU486, siRNA targeting GR, non-selective cation channel blocker 2-aminoethyldiphenylborate, or in the absence of extracellular Ca(2+), indicating Re is indeed an agonistic ligand for the GR and the activated GR induces rapid Ca(2+) influx and NO production in endothelial cells.
Adenocarcinoma of the uterine cervix: the presence of human papillomavirus and the method of detection (2003)

The absence of HPV was significantly associated with a high age at diagnosis. Pap screening had a limited effect in detecting adenocarcinoma at an early stage.
Low-complexity distributed fault detection for wireless sensor networks (2015)

To guarantee its integrity, a wireless sensor network needs to efficiently detect faulty nodes producing erroneous measurements. This paper proposes a fully distributed fault detection algorithm. A node first collects the measurements of its neighborhood, processes them to decide whether they contain outliers, and broadcasts the result. Then, it decides autonomously about its functioning status. The detection algorithm is proposed in two variants, depending on the proportion of faulty nodes in the network. A theoretical analysis of the probability of error and of the convergence of the algorithm is provided. The tradeoff between false alarm probability and detection probability is characterized using simulation.
Control of Vibrations (2006)

This chapter contains sections titled: Introduction Controllability and Observability Eigenstructure Assignment Optimal Control Observers (Estimators) Realization Reduced-order Modeling Modal Control in State Space Modal Control in Physical Space Robustness Positive Position Feedback MATLAB Commands for Control Calculations Chapter Notes References Problems
SAR Polarimetry to Observe Oil Spills (2007)

A study on sea oil spill observation by means of polarimetric synthetic aperture radar (SAR) data is accomplished. It is based on the use of a polarimetric constant false alarm rate filter to detect dark patches over SAR images. Then, the target decomposition theorem is exploited to distinguish oil spills and look-alikes. Experiments are conducted on polarimetric SAR data acquired during the SIR-C/X-SAR mission on October 1994. The data were processed and calibrated at the Jet Propulsion Laboratory, National Aeronautics and Space Administration. Results show that the new polarimetric approach is able to assist classification
Comprehending non-linear text (1987)

By studying the structure of written discourse and the processes by which readers acquire information from texts, we have learned a great deal about how to design texts that facilitate learning. However, recent advances in computer technology have enabled the development of new forms of text that violate standard assumptions of what texts are like. These new forms may pose serious problems for learning because they lack discourse features that readers rely on for assimilating new information. In particular, readers traditionally rely on the writer to determine the sequence of topics and to employ conventional cues that signal relationships among topics, such as relative importance or chronology. However, on-line hypertext systems present texts non-linearly, requiring readers to decide what information to read and in what order. This paper assesses the potential impact of non-linear texts on theories of discourse and on current cognitive theories of text processing. It also describes research in progress on readers' sequencing strategies in hypertext. Research on the effect of hypertext on reading will have important practical implications for designing hypertext systems that satisfy readers' needs.
Private Landlords and Redevelopment: "The Ward" in Toronto, 1890-1920 (1995)

Drawing on contemporary accounts of inner-city slums and on an analysis of assessment roll data, this paper examines patterns of speculation, property exchange, improvement and redevelopment in "The Ward" in Toronto, contrasting the depression of the 1890s with the return of boom conditions prior to World War I. It is argued that contemporary critiques of speculative landlords hoarding land and neglecting the maintenance and improvement of existing buildings while they waited for land values to increase, were an oversimplification of a much more complex reality. During the property boom of the early 1900s most sites changed hands at least once, partly reflecting the desire of recent immigrants to obtain property. There were also differences in the attractiveness of the land, and hence the rate of increase in its value, and the pressure for redevelopment of different parts of "The Ward". There were also differences over time, not only between the 1890s depression and the 1900s boom, but also between the 1900s and the mid-1910s, when the Bureau of Municipal Research reported on the area Nor was it likely, given the continuing demand for accommodation among a rapidly increasing population, that landlords were, as they claimed, failing to make profits from renting out poor-quality dwellings and stores. In this respect, the experience of tum-of-the-century Toronto contrasted with the "rent gap" hypothesis used by urban geographers to account for the redevelopment of neglected inner-city neighbourhoods during more recent property booms.
Spatiotemporal dynamics of astroglial and microglial responses after photothrombotic stroke in the rat brain (2008)

The effects of photothrombotic stroke in primary somatosensory cortex on astroglial and microglial activation in various regions of lesioned brain were examined at different time points, using immunohistochemistry and lectin binding. The increase in GFAP expression was observed exclusively in the ipsilateral hemisphere, both in the perilesional area and cortical regions distant from the infarct. This remote increase was detectable up to sixty days after the infarct. Transient GFAP elevation was also found in the hippocampus one day after photothrombosis, whereas it was more prolonged in amygdala, as demonstrated at four days after lesion. In contrast to a widespread astrocytic activation, the microglial response was shortlasting and local, confined to lesion and perilesional area. Widespread and prolonged activation of astrocytes after stroke may provide factors promoting slowly developing recovery processes in the whole brain, while microglial response seems to be involved in local repair and removal of cellular debris.
Ultrathin, ultrasmooth, and low-loss silver films via wetting and annealing (2010)

We have demonstrated that a thermal annealing treatment can reduce the optical losses in ultrathin, ultrasmooth, silver films deposited on a Ge wetting layer to values as low as the bulk material value and at the same time maintain an ultrasmooth surface. The annealing effect is sensitive to the annealing temperature and time, both of which should be carefully controlled. This annealing treatment is also effective for Ag–SiO2 multilayer composite films.
The Delayed-Release Combination of Doxylamine and Pyridoxine (Diclegis®/Diclectin®) for the Treatment of Nausea and Vomiting of Pregnancy (2014)

Nausea and vomiting of pregnancy (NVP) affects up to 85 % of all pregnancies. Effective treatment can greatly improve a woman's quality of life, reduce the risk for maternal and fetal complications, and reduce healthcare costs. Unfortunately, many women receive either no pharmacological treatment or are recommended therapies for which fetal safety and efficacy have not been established. First-line treatment of NVP, as recommended by several leading healthcare and professional organizations, is the combination of doxylamine and pyridoxine. This combination, formulated as a 10 mg/10 mg delayed-release tablet, was approved by the US Food and Drug Administration (FDA) for the treatment of NVP in April 2013 under the brand name Diclegis(®), and has been on the Canadian market since 1979, currently under the brand name Diclectin(®). The efficacy of Diclegis(®)/Diclectin(®) has been demonstrated in several clinical trials, and, more importantly, studies on more than 200,000 women exposed to doxylamine and pyridoxine in the first trimester of pregnancy have demonstrated no increased fetal risk for congenital malformations and other adverse pregnancy outcomes. The present review aims to present the scientific evidence on the effectiveness and fetal safety of Diclegis(®)/Diclectin(®) for the treatment of NVP to justify its use as first-line treatment for NVP.
Application of Sinter-Hardenable Materials for Advanced Automotive Applications such as Gears, Cams, and Sprockets (2000)

<div class="htmlview paragraph">Recent demands within the automotive industry have been for applications requiring high hardness, high hardenability, and increased mechanical performance. These often conflicting requirements necessitated the development of new materials that offer high as-sintered hardness and good static/dynamic mechanical properties without the added expense of a secondary heat treatment. Traditionally, sinter-hardening materials have offered acceptable hardness but at the expense of mechanical properties and sintered density. This paper will document a series of sinter hardening materials that offer good compressibility, high hardness and enhanced mechanical properties. The discussion will focus on utilization of these materials in automotive applications (within both the engine and transmission) such as gears, cams and sprockets that are currently produced by either the press, sinter, and heat treat process or by conventional machining of a casting or wrought material.</div>
H<sub>2</sub>/air autoignition: The nature and interaction of the developing explosive modes (2015)

Appropriate algorithmic tools are employed for the analysis of the explosive modes developing during the autoignition of homogeneous mixtures. The ability of these tools to provide significant physical understanding is demonstrated in the case of the homogeneous ignition of a stoichiometric H2/air mixture, modelled by two different chemical kinetics mechanisms. It is shown that the ignition process evolves in two stages. The first stage is characterised by the development of two explosive timescales (one fast and one slow), that lead the system away from equilibrium. As the end of the first stage is approached, the two explosive timescales converge, they merge and then they disappear. In the second stage only dissipative timescales develop, which drive the system all the way to equilibrium. It is shown that throughout the first stage the fast explosive timescale is generated by chain reactions. The slow explosive timescale is initially generated by an initiation reaction that produces the radicals required for the start-up of the fast mode, while later on it is generated by reactions that are responsible for the heat released. These findings are validated with sensitivity analysis results for the ignition delay time and are employed in order to clarify the discrepancies in the solution provided by the two different chemical kinetics mechanisms considered.
3D Point Cloud Model Color Adjustment By Combining Terrestrial Laser Scanner And Close Range Photogrammetry Datasets (2016)

3D models obtained with advanced survey techniques such as close-range photogrammetry and laser scanner are nowadays particularly appreciated in Cultural Heritage and Archaeology fields. In order to produce high quality models representing archaeological evidences and anthropological artifacts, the appearance of the model (i.e. color) beyond the geometric accuracy, is not a negligible aspect. The integration of the close-range photogrammetry survey techniques with the laser scanner is still a topic of study and research. By combining point cloud data sets of the same object generated with both technologies, or with the same technology but registered in different moment and/or natural light condition, could construct a final point cloud with accentuated color dissimilarities. In this paper, a methodology to uniform the different data sets, to improve the chromatic quality and to highlight further details by balancing the point color will be presented.
Noise in electric machines: a review (1999)

Increasing awareness of industrial noise pollution and emerging stricter standards have made noise an important topic of research in electric machines. This work is a state-of-the-art review on the identification of noise sources and techniques to mitigate noise. It points the reader to relevant research in the past on acoustic noise identification and mitigation techniques. The paper also describes the current standards and practices and some of the suggestions in literature to intensify these standards. The paper summarizes the emerging future directions in acoustic noise mitigation studies.
Computer aided conversation for severely physically impaired non-speaking people (1993)

This paper reports the development of a computer-aided conversation prosthesis which is designed for severely physically impaired non-speaking people. The research methodology was to model aspects of conversational structure derived from the field of conversation analysis within a prototype conversational prosthesis. The prototype was evaluated in empirical investigations which also suggested successful strategies for carrying out satisfying conversation using such a system. Two versions have been built and tested, one using an able-bodied operator to test the feasibility of creating conversation from prestored material, the second being used by a physically impaired non-speaking operator. The prototype demonstrated the advantages of this interface design in helping the user to carry out natural sounding and satisfying conversations.
Uniform Luminance Light Field Near Eye Display Using Pinhole Arrays and Gradual Virtual Aperture (2016)

In conventional light field near eye display (LF-NED) using pinhole aperture arrays, as the pupil size changes under different conditions, the overlapping area of adjacent elemental images is not certain. This is the primary cause of an uncertain net-shaped bright-dark pattern on the image plane. In this paper, a proof-of-concept light field near eye display prototype for virtual reality applications based on pinhole aperture arrays is built, with a binocular field of view (FOV) of 84°×77°. Then, we design gradual virtual apertures on the original light field image, to relieve the net-shaped bright-dark pattern. By blocking the useless part of the image and modulating the luminance of the overlapping areas gradually according to their positions, the bright-dark pattern is effectively relieved and an approximately uniform luminance distribution on the image plane is generated.
TERMES: An Autonomous Robotic System for Three-Dimensional Collective Construction (2011)

Collective construction is the research area in which autonomous multi-robot systems build structures according to user specifications. Here we present a hardware system and high-level control scheme for autonomous construction of 3D structures under conditions of gravity. The hardware comprises a mobile robot and specialized passive blocks; the robot is able to manipulate blocks to build desired structures, and can maneuver on these structures as well as in unstructured environments. We describe and evaluate the robot's key capabilities of climbing, navigation, and manipulation, and demonstrate its ability to perform complex tasks that combine these capabilities by having it autonomously build a ten-block staircase taller than itself. In addition, we outline a simple decentralized control algorithm by which multiple simultaneously active robots could autonomously build user-specified structures, working from a high-level description as input.
A new architecture for high throughput, low latency NB-LDPC check node processing (2015)

Non-binary low-density parity-check codes have superior communications performance compared to their binary counterparts. However, to be an option for future standards, efficient hardware architectures must be developed. State-of-the-art decoding algorithms lead to architectures suffering from low throughput and high latency. The check node function accounts for the largest part of the decoders overall complexity. In this paper a new hardware aware check node algorithm and its architecture is proposed. It has state-of-the-art communications performance while reducing the decoding complexity. The presented architecture has a 14 times higher area efficiency, increases the energy efficiency by factor 2.5 and reduces the latency by factor of 3.5 compared to state-of-the-art architectures.