gebhart/patrepeval huggingface dataset:
Deformación progresiva de la Zona Sudportuguesa: Plegamiento y cizallamiento de secuencias multicapa (1998)

Folds, reverse faults and thrusts in the South Portuguese Zone (SW Iberia) have been classically related with the progressive deformation of the Variscan thrust -fold belt. All structures verge toward South and Southwest. The style of folds in multilayers is analysed in this work. Ductile, brittle-ductile and brittle shear zones cut across the tight folds wisch exibit a WNW-ESE trend. The dip of axial surfaces varies from moderately inclined to upright. Detailed research in the Valverde del Camino anticlinal has revealed the existence of dome-basin patterns of folds related with the thrusts. The regional structures such as the Puebla de Guzman and Valverde del Camino anticlinorium are associated with the geometry of thrusts
Non-invasive mechanical properties estimation of embedded objects using tactile imaging sensor (2013)

Non-invasive mechanical property estimation of an embedded object (tumor) can be used in medicine for characterization between malignant and benign lesions. We developed a tactile imaging sensor which is capable of detecting mechanical properties of inclusions. Studies show that stiffness of tumor is a key physiological discerning parameter for malignancy. As our sensor compresses the tumor from the surface, the sensing probe deforms, and the light scatters. This forms the tactile image. Using the features of the image, we can estimate the mechanical properties such as size, depth, and elasticity of the embedded object. To test the performance of the method, a phantom study was performed. Silicone rubber balls were used as embedded objects inside the tissue mimicking substrate made of Polydimethylsiloxane. The average relative errors for size, depth, and elasticity were found to be 67.5%, 48.2%, and 69.1%, respectively. To test the feasibility of the sensor in estimating the elasticity of tumor, a pilot clinical study was performed on twenty breast cancer patients. The estimated elasticity was correlated with the biopsy results. Preliminary results show that the sensitivity of 67% and the specificity of 91.7% for elasticity. Results from the clinical study suggest that the tactile imaging sensor may be used as a tumor malignancy characterization tool.
A fully automatic gridding method for cDNA microarray images (2011)

Extensive experiments on real-life microarray images and a comparison to other methods show that the proposed method performs these tasks fully automatically and with a very high degree of accuracy. Moreover, unlike previous methods, the proposed approach can be used in various type of microarray images with different resolutions and spot sizes and does not need any parameter to be adjusted.
AwToolkit (2014)

Increasing screen real-estate allows for the development of applications where a single user can manage a large amount of data and related tasks through a distributed user interface. However, such users can easily become overloaded and become unaware of display changes as they alternate their attention towards different displays. We propose AwToolkit, a novel widget set for developers that supports users in maintaing awareness in multi-display systems. The AwToolkit widgets automatically determine which display a user is looking at and provide users with notifications with different levels of subtlety to make the user aware of any unattended display changes. The toolkit uses four notification levels (unnoticeable, subtle, intrusive and disruptive), ranging from an almost imperceptible visual change to a clear and visually saliant change. We describe AwToolkit's six widgets, which have been designed for C# developers, and the design of a user study with an application oriented towards healthcare environments. The evaluation results reveal a marked increase in user awareness in comparison to the same application implemented without AwToolkit.
Large-Scale Calculation of Low-Frequency-Induced Currents in High-Resolution Human Body Models (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We present large-scale computations of currents induced in the human body, arising from an external low-frequency magnetic-field source. The calculations are performed using the Ex-SPFD approach; an extension of the classical SPFD approach, that can handle arbitrarily shaped magnetic-field sources and highly conductive material inside the computational domain. In order to sufficiently resolve even small organs such as the eye, very fine spatial resolution is needed. Such fine resolution results in very large systems of equations. Problems consisting of up to 200 millions of unknowns are presented. </para>
Type 1 Diabetes: Clinical and Experimental (2005)

Uremic patients undergoing hemodialysis (HD) are known to be highly susceptible to infections. Recent data indicate that in addition to its well-known stimulating effects on red cell production, erythropoietin (EPO) may also have immunomodulating properties. The aim of this study was to examine the effect of EPO on lectin-induced T-lymphocyte transformation in uremic patients, as part of its effect on the immune response. Sixteen HD patients and 20 age- and sex-matched healthy controls were compared before and after 6 and 20 weeks of EPO treatment. T lymphocytes were analyzed for their mitogenic activity following treatment with phytohemagglutinin (PHA), concanavalin A (CON A) and anti-CD3 by measuring 3H-thymidine incorporation. HD patients showed reduced mitogenic responses to all mitogens tested, compared to healthy controls. During the 6 weeks of EPO administration, a significant increase in T-lymphocyte activity could be demonstrated following exposure to all three mitogens (PHA, from 32 ± 2 to 45 ± 8; CON A, from 11 ± 3 to 25 ± 9; anti-CD3, from 11 ± 3 to 22 ± 5, means ± SD). This increase was augmented after 5 months of EPO treatment. We conclude therefore that EPO improves in vitro T-cell mitogenic proliferation, even after short periods of treatment.
Theoretical and practical implications for plasmapheresis in autoimmune inner ear disease (1989)

Immune-mediated inner ear disease, by convention called autoimmune inner ear disease (AIED), has established clinical profile guidelines for diagnosis. Treatment consists of steroid and/or cytotoxic drug immunosuppression. The role of plasmapheresis (PMP) in the treatment of AIED has not been defined. Lack of a precise serological marker prevents accurate immunological understanding. Definition is, of course, difficult in a disease whose natural history is not well delineated. Successful use of PMP in one steroid and cytotoxic drug intolerant patient with AIED led to its use in a total of eight patients. The rationale for PMP was based on its known effectiveness in other autoimmune diseases and thus, its potential use in AIED. Improved auditory function occurred in 6 of the 8 patients, 3 of whom have been followed for over 3 years. Three of the six no longer require immunosuppressant medication. PMP can be used as an alternative or adjunctive therapy in AIED. These preliminary results suggest PMP can stabilize or improve auditory and vestibular symptoms in selected patients. Its use as a first line therapy followed by cytotoxic immunosuppressants bears consideration.
GLOBAL AND LOCAL REACTIVITY DESCRIPTORS FOR PICLORAM HERBICIDE: A THEORETICAL QUANTUM STUDY (2014)

In this work, we studied the reactivity of picloram in the aqueous phase at the B3LYP/6-311++G(2d,2p) and MP2/6-311++G(2d,2p) levels of theory through global and local reactivity descriptors. The results obtained at the MP2 level indicate that the cationic form of picloram exhibits the highest hardness while the anionic form is the most nucleophilic. From the Fukui function values, the most reactive site for electrophilic and free radical attacks are on the nitrogen in the pyridine ring. The more reactive sites for nucleophilic attacks are located on the nitrogen atom of the amide group and on the carbon atoms located at positions 2 and 3 in the pyridine ring.
Polymorphism of Racemic Poly(<scp>l</scp>-lactide)/Poly(<scp>d</scp>-lactide) Blend: Effect of Melt and Cold Crystallization (2013)

The crystallization and melting behaviors and crystalline structure of melt and cold crystallized poly(L-lactide)/poly(D-lactide) (PLLA/PDLA) blend were investigated by differential scanning calorimetry (DSC) and wide-angle X-ray diffraction (WAXD), respectively. The isothermal crystallization kinetics during the melt and cold crystallization process were analyzed using the Avrami equation. The overall crystallization rate constant (k) of cold crystallization is much higher than that of melt crystallization. Moreover, k as a function of crystallization temperature shows different trends in melt and cold crystallization, indicating different crystallization mechanisms in the melt and cold crystallization. The polymorphic crystallization of homocrystallites (the transition crystallization temperature from δ to α form) is not altered by either the equimolar blending of PLLA and PDLA or the type of crystallization procedures, while the crystallization window for exclusive stereocomplex crystallites is widened from 170 °C for melt crystallization to 170-200 °C for cold crystallization. The stereocomplex crystallites are hard to form in both melt and cold crystallization at crystallization temperatures of 90 and 100 °C, and the crystallinity of stereocomplex crystallites for cold crystallization is higher than that of melt crystallization at temperatures above 110 °C. Especially, a pure and significantly higher crystallinity of stereocomplex crystallites can be achieved at 170-200 °C by cold crystallization. The results provide a huge possibility to control stereocomplex crystallization to enlarge its applications.
QEXAFS study of the sulfidation of NiMo/Al<sub>2</sub>O<sub>3</sub> hydrotreating catalysts (2001)

Quick-scanning extended X-ray absorption fine structure (QEXAFS) spectroscopy was employed to investigate in situ the sulfidation of Mo and Ni in y-AI2O3-supported hydrotreating catalysts modified with chelating ligands. Mo K-edge QEXAFS enabled the detection of an intermediate product in the sulfidation of Mo. The parameters obtained from the fits of the QEXAFS spectra showed that this product consists of compounds similar to Mo2S2-(12) or Mo3S2-(13). QEXAFS also demonstrated that the sulfidation of Ni is strongly influenced by the presence of chelating ligands. Classical EXAFS spectra of the sulfided catalysts showed that Ni forms small sulfided clusters, the size of which is influenced by the presence or absence of the chelating agents.
Acid Effects in the Radiation Grafting of Monomers to Polymers, Particularly Polyethylene (1980)

Inclusion of mineral acid in monomer solutions is shown to enhance grafting to polyethylene under certain gamma irradiation conditions. The predominant variables affecting the optimisation of the acid effect in these reactions are considered. These include type of solvent, acid structure, competing homopolymer formation and radiation dose-rate. A mechanism for the acid effect is proposed. The advantages of its use in preparative copolymerisation reactions are discussed. The present polyethylene data are compared with analogous acid enhancement observed in radiation grafting to wool, cellulose, polypropylene and PVC. The data show that the present acid effect appears to be a general phenomenon in radiation copolymerisation reactions.
Customized Pricing: Win-Win or End Run? (2012)

Modern technology, particularly as associated with internet shopping, permits excellent estimations of individual consumer willingness to pay. Customized pricing is defined as a pricing strategy based upon such individualized estimates--each customer is presented with an individual price. The paper addresses the ethical, legal, and managerial challenges of customized pricing practice. A simple empirical study is included to illustrate not only the economic effects of customized pricing but, also, the surprising finding of initial consumer satisfaction with customized prices. Participants showed considerably less satisfaction, however, upon learning the nature of the pricing technique.
Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors (2001)

Factors that affect naive T cell proliferation in syngeneic lymphopenic hosts were investigated. 2C T cell receptor (TCR) transgenic T cells lacking both CD8 and CD4 survived but hardly proliferated. Proliferation of CD8(+) 2C cells was proportional to the abundance of cognate peptide/MHC complexes and was severely inhibited by injection of anti-CD8 antibody. Weakly reactive self-peptides slightly enhanced CD8(+) 2C cell proliferation whereas a potent agonist peptide promoted much more rapid proliferation, but inflammation-stimulating adjuvant had only a small effect on the rate of cell proliferation. The findings suggest that under uniform lymphopenic conditions, the widely different rates of proliferation of T cells expressing various TCR, or the same TCR in the presence or absence of CD8, reflect the strength of interaction between TCR and MHC associated with particular self-peptides.
Security Modeling and Analysis of Cross-Protocol IoT Devices (2017)

In the Internet of Things (IoT), smart devices are connected using various communication protocols, such as Wi-Fi, ZigBee. Some IoT devices have multiple built-in communication modules. If an IoT device equipped with multiple communication protocols is compromised by an attacker using one communication protocol (e.g., Wi-Fi), it can be exploited as an entry point to the IoT network. Another protocol (e.g., ZigBee) of this IoT device could be used to exploit vulnerabilities of other IoT devices using the same communication protocol. In order to find potential attacks caused by this kind of cross-protocol devices, we group IoT devices based on their communication protocols and construct a graphical security model for each group of devices using the same communication protocol. We combine the security models via the cross-protocol devices and compute hidden attack paths traversing different groups of devices. We use two use cases in the smart home scenario to demonstrate our approach and discuss some feasible countermeasures.
Opposing Effects of Retinoic Acid and Dexamethasone on Cellular Retinol-Binding Protein Ribonucleic Acid Levels in the Rat* (1991)

Cellular retinol-binding protein (CRBP) is a potential mediator of vitamin A action. To determine whether retinoic acid and dexamethasone administration, alone and in combination, influence CRBP gene expression, adult female vitamin A-sufficient Sprague-Dawley rats randomly received 1) all-trans retinoic acid (100 micrograms) by intragastric intubation, 2) dexamethasone (2 micrograms/g BW) by ip injection, or 3) both all-trans retinoic acid and dexamethasone in the same doses. Control animals received either cottonseed oil by intragastric intubation or saline by ip injection. Six hours after treatment, lung and liver tissue were collected for Northern blot analysis with the radiolabeled cDNA specific for rat CRBP. Retinoic acid administration increased the amount of lung CRBP mRNA only, whereas dexamethasone decreased both lung and liver CRBP mRNA abundance. In animals treated with both retinoic acid and dexamethasone, CRBP mRNA abundance was also reduced. We conclude that CRBP gene expression can be modulated by both retinoic acid and dexamethasone in the vitamin A-sufficient animal. In the whole animal, our findings indicate that dexamethasone not only represses CRBP gene expression, but also opposes the effect of retinoic acid.
Cloning and Characterization of a cDNA That Encodes a 70-kDa Novel Human Thyroid Autoantigen (1989)

cDNA clones were isolated by screening a human thyroid carcinoma lambda gt11 library with immunoglobulins purified from serum of a patient with autoimmune Graves' disease. One clone (ML8) containing a 1.25-kilobase (kb) insert hybridized with a single 2.0-kb poly(A+) mRNA in human thyroid and lymphocytes but not in human brain, liver, kidney, or muscle. In addition, this probe also hybridized with a single 2.0-kb poly(A+) mRNA from a rat thyroid cell line (FRTL-5). An apparently full length 2,074-base pair (bp) human cDNA was obtained and sequenced. The nucleotide sequence of the 2,074-bp cDNA includes a 5'-noncoding sequence of 17 bp, a 1827-bp open reading frame, and a 222-bp 3'-noncoding sequence. The canonical polyadenylation signal AATAAA is present 18 bp upstream of the poly(A) tail. This cDNA encodes a 69,812-dalton protein with two potential N-linked glycosylation sites and at least one potential membrane spanning domain. Immunoprecipitation of the in vitro translated protein by sera from several patients with Graves' disease argues that the 69,812-dalton protein is an autoantigen.
Development of Genomic Array Footprinting for Identification of Conditionally Essential Genes in<i>Streptococcus pneumoniae</i> (2007)

Streptococcus pneumoniae is a major cause of serious infections such as pneumonia and meningitis in both children and adults worldwide. Here, we describe the development of a high-throughput, genome-wide technique, genomic array footprinting (GAF), for the identification of genes essential for this bacterium at various stages during infection. GAF enables negative screens by means of a combination of transposon mutagenesis and microarray technology for the detection of transposon insertion sites. We tested several methods for the identification of transposon insertion sites and found that amplification of DNA adjacent to the insertion site by PCR resulted in nonreproducible results, even when combined with an adapter. However, restriction of genomic DNA followed directly by in vitro transcription circumvented these problems. Analysis of parallel reactions generated with this method on a large mariner transposon library showed that it was highly reproducible and correctly identified essential genes. Comparison of a mariner library to one generated with the in vivo transposition plasmid pGh:ISS1 showed that both have an equal degree of saturation but that 9% of the genome is preferentially mutated by either one. The usefulness of GAF was demonstrated in a screen for genes essential for surviving zinc stress. This identified a gene encoding a putative cation efflux transporter, and its deletion resulted in an inability to grow under high-zinc conditions. In conclusion, we developed a fast, versatile, specific, and high-throughput method for the identification of conditionally essential genes in S. pneumoniae.
Emotion Recognition Using Electroencephalography Signals of Older People for Reminiscence Therapy (2022)

<b>Objective:</b> Numerous communication support systems based on reminiscence therapy have been developed. However, when using communication support systems, the emotional assessment of older people is generally conducted using verbal feedback or questionnaires. The purpose of this study is to investigate the feasibility of using Electroencephalography (EEG) signals for automatic emotion recognition during RT for older people. <b>Participants:</b> Eleven older people (mean 71.25, SD 4.66) and seven young people (mean 22.4, SD 1.51) participated in the experiment. <b>Methods:</b> Old public photographs were used as material for reminiscence therapy. The EEG signals of the older people were collected while the older people and young people were talking about the contents of the photos. Since emotions change slowly and responses are characterized by delayed effects in EEG, the depth models LSTM and Bi-LSTM were selected to extract complex emotional features from EEG signals for automatic recognition of emotions. <b>Results:</b> The EEG data of 8 channels were inputted into the LSTM and Bi-LSTM models to classify positive and negative emotions. The recognition highest accuracy rate of the two models were 90.8% and 95.8% respectively. The four-channel EEG data based Bi-LSTM also reached 94.4%. <b>Conclusion:</b> Since the Bi-LSTM model could tap into the influence of "past" and "future" emotional states on the current emotional state in the EEG signal, we found that it can help improve the ability to recognize positive and negative emotions in older people. In particular, it is feasible to use EEG signals without the necessity of multimodal physiological signals for emotion recognition in the communication support systems for reminiscence therapy when using this model.
Reception of Dual-LP11-Mode CO-OFDM Signals through Few-mode Compatible Optical Add/Drop Multiplexer (2012)

We report successful reception of dual-LP11-mode CO-OFDM signals traversing fewmode compatible optical add/drop multiplexer (OADM). The power penalties for add, drop and through ports are 2.6, 2.4, 0.7 dB, respectively for 3⨉318 Gb/s OFDM signals.
Enhancement of Glenoid Prosthesis Anchorage Using Burying Technique (2008)

Seventy unconstrained total shoulder prostheses were evaluated with a mean follow-up of 42 months (range, 24-96 months). A flat polyethylene cemented glenoid device with 2 fixation points was always used. It was a slightly undersized device to facilitate insertion. Glenoid modifications were assessed on anteroposterior (AP) views (3 rotations) and with a modified axillary lateral view using Bernageau technique. We noted the thickness of the radiolucent lines, whether they were complete or incomplete, and how they had evolved over 12 months. On coronal x-rays, only 7 devices had no radiolucent line at 12 months, 42 had a partial radiolucent line, and 20 a complete radiolucent line, including 2 with a radiolucent line greater than 2 mm that seemed to be loose. One device had migrated secondary to an anterior dislocation. Radiolucent lines were clear in 90% of cases and had evolved in 27% of cases. Radiographically, the loosening rate was 28%. Comparison of the clear radiographic radiolucent lines, clinical parameters (constant score), and the position of the implants did not demonstrate any predictive factor for evolution of the periglenoid radiolucent lines. Age- and sex-weighted constant score at 42 months was 87.7 %. The technique was developed to spare the glenoid bone, which is often deteriorated by the degenerative process, and to obtain stable primary fixation on the subchondral bone. The clear radiolucent lines noted immediately postoperatively led us to improve our technique by making small perforations in the subchondral bone and by performing cementing in 2 stages. Although no revision surgery was performed, the bone preservation observed suggests that this would be possible in good conditions.