gebhart/patrepeval huggingface dataset:
Biomimetic self-assembling acylphthalocyanines (2015)

We synthesized a series of biomimetic self-assembling phthalocyanines equipped with carbonyl groups as recognition motifs, a central zinc atom and diverse solubilizing alkyl chains mimicking for the first time with these robust pigments the natural chlorosomal bacteriochlorophylls. Upon self-assembly a very broad and red-shifted Q-band absorption extending to over 900 nm is put into evidence.
Intrinsically Polar Piezoelectric Self-Assembled Oligopeptide Monolayers (2021)

Flexible, bio-compatible piezoelectric materials are of considerable research interest for a variety of applications, but many suffer from low response or high cost to manufacture. Herein, novel piezoelectric force and touch sensors based on self-assembled monolayers of oligopeptides are presented which produce large piezoelectric voltage response and are easily manufactured without the need for electrical poling. While the devices generate modest piezoelectric charge constants (d33) of up to 9.8 pC N−1, they exhibit immense piezoelectric voltage constants (g33) up to 2 V m N−1. Furthermore, a flexible device prototype is demonstrated that produces open-circuit voltages of nearly 6 V under gentle bending motion. Improvements in peptide selection and device construction promise to further improve the already outstanding voltage response and open the door to numerous practical applications.
Polymorphisms of the Phosphodiesterase 4D, cAMP-Specific ( <i>PDE4D</i> ) Gene and Risk of Ischemic Stroke (2006)

We found modest associations between several PDE4D gene polymorphisms and risk of incident ischemic stroke in men without baseline hypertension in this prospective, non-Icelandic study. Although of borderline statistical significance, the direction and magnitude of the effect for SNP42 parallels that observed in a recent study evaluating women from an independent, nested case-control study.
Table of interest (2018)

Energy overheads continue to be a major impediment for wearable based activity recognition systems. We proposed a hybrid approach, which combines wearable-based human sensing with object interaction tracking, for robust detection of ADLs in smart homes. Our proposed framework includes: (a) battery less, low sampling rate, wearable RF sensor tags, that are powered intermittently by an RFID reader, and (b) additional passive RF tags, mounted on daily use objects, that capture the presence and use of specific objects while performing such ADLs. Using an initial experimental set up, we show the ability to recognize activities like eating, typing and reading, which are generally performed on a table, with an accuracy of 96%. Moreover, by capturing the item-level interactions of a user while performing ADLs, this approach can help observe the evolution of fine-grained behavioral changes and anomalies in an individual.
Characterization of a Chicken Monoclonal Antibody That Recognizes the Apical Complex of Eimeria acervulina Sporozoites and Partially Inhibits Sporozoite Invasion of CD8 + T Lymphocytes In vitro (1996)

A stable chicken hybridoma secreting a monoclonal antibody (mAb) that detects the apical complex of Eimeria acervulina sporozoites has been developed by fusing a thymidine kinase (TK)-deficient chicken myeloma with spleen cells from chickens immunized with sporozoite antigen. The mAb, designated as 6D-12-G10, recognized the apical complex of a sporozoite of 20-21 kDa molecular mass on western blots. Immunoelectron microscopic examination revealed that mAb 6D-12-G10 stained the conoid antigen. Furthermore, mAb 6D-12-G10 inhibited the invasion of sporozoites into CD8+ T cells in vitro. These results suggest that the conoid may play an important role in the recognition and invasion of host cells by Eimeria sporozoites.
Classification of self-assembling protein nanoparticle architectures for applications in vaccine design (2017)

We introduce here a mathematical procedure for the structural classification of a specific class of self-assembling protein nanoparticles (SAPNs) that are used as a platform for repetitive antigen display systems. These SAPNs have distinctive geometries as a consequence of the fact that their peptide building blocks are formed from two linked coiled coils that are designed to assemble into trimeric and pentameric clusters. This allows a mathematical description of particle architectures in terms of bipartite (3,5)-regular graphs. Exploiting the relation with fullerene graphs, we provide a complete atlas of SAPN morphologies. The classification enables a detailed understanding of the spectrum of possible particle geometries that can arise in the self-assembly process. Moreover, it provides a toolkit for a systematic exploitation of SAPNs in bioengineering in the context of vaccine design, predicting the density of B-cell epitopes on the SAPN surface, which is critical for a strong humoral immune response.
Logic Devices with Spin Wave Buses: Potential Advantages and Shortcoming (2008)

The authors analyze the performance and estimate the efficiency of the spin-wave based logic devices. The main potential advantage of using spin wave for information transmission and processing is that a bit of information can be transmitted without use of an electric current. Spin-wave based devices may find an application as an interface between the electronic and magnetic circuits. The authors show the schematics of the integration of the spin-wave based devices with conventional electron-based circuit. The input information is received in the form of voltage pulses. Next, it is converted into the spin wave signals, where logic state 1 and 0 corresponds to the phases of the spin waves. Spin-wave based device accomplishes computation using spin wave signals and provides the output on the form of voltage pulses.
Stereospecific Substitution of Allylic Alcohols (2010)

The authors disclose a stereo­specific allylic amination of optically active allylic alcohols using an iridium phosphoramidite catalyst and sulfamic acid as ammonia equivalent. An active iridium phosphoramidite complex is also isolated and characterized. Few examples of addition of free ammonia to primary allylic alcohols exist, but high ammonia equivalents and dilution are necessary to prevent overalkylation (T. Nagano, S. Kobayashi J. Am. Chem. Soc. 2009, 131, 4200; M. J. Pouy, L. M. Stanley, J. F. Hartwig J. Am. Chem. Soc. 2009, 131, 11312).
Aqueous reactivity of polyacetylene: pH dependence (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAqueous reactivity of polyacetylene: pH dependenceAnthony. Guiseppi-Elie and Gary E. WnekCite this: J. Phys. Chem. 1990, 94, 7, 3192–3196Publication Date (Print):April 5, 1990Publication History Published online1 May 2002Published inissue 5 April 1990https://pubs.acs.org/doi/10.1021/j100370a081https://doi.org/10.1021/j100370a081research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Electro-optical performance of a new, black-white and highly multiplexable liquid crystal display (1987)

A new, low bias tilt field-effect liquid crystal display (LCD) is presented with better image quality than supertwist or superbirefringence LCD’s at the same high level of multiplexing. In its positive contrast mode, the display image is black on white with virtually no inherent coloration and with a comparably large contrast as that of twisted nematic LCD’s. The viewing range of the display is as wide as that of superbirefringence LCD’s, whereas its image quality is an order of magnitude less dependent on cell gap variations. With specifically designed liquid crystal mixtures, multiplexing ratios of 1000:1 and response times below 300 ms result.
Genetic and Cytogenetic Mapping of <i>DMI1, DMI2</i>, and <i>DMI3</i> Genes of <i>Medicago truncatula</i> Involved in Nod Factor Transduction, Nodulation, and Mycorrhization (2002)

The DMI1, DMI2, and DMI3 genes of Medicago truncatula, which are required for both nodulation and mycorrhization, control early steps of Nod factor signal transduction. Here, we have used diverse approaches to pave the way for the map-based cloning of these genes. Molecular amplification fragment length polymorphism markers linked to the three genes were identified by bulked segregant analysis. Integration of these markers into the general genetic map of M. truncatula revealed that DMI1, DMI2, and DMI3 are located on linkage groups 2, 5, and 8, respectively. Cytogenetic studies using fluorescent in situ hybridization (FISH) on mitotic and pachytene chromosomes confirmed the location of DMI1, DMI2, and DMI3 on chromosomes 2, 5, and 8. FISH-pachytene studies revealed that the three genes are in euchromatic regions of the genome, with a ratio of genetic to cytogenetic distances between 0.8 and 1.6 cM per microm in the DMI1, DMI2, and DMI3 regions. Through grafting experiments, we showed that the genetic control of the dmi1, dmi2, and dmi3 nodulation phenotypes is determined at the root level. This means that mutants can be transformed by Agrobacterium rhizogenes to accelerate the complementation step of map-based cloning projects for DMI1, DMI2, and DMI3.
Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice (2017)

Nociceptors rely on cap-dependent translation to rapidly induce protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3' end of mRNA in nociceptor sensitization. Poly(A)-binding protein (PABP) stimulates translation initiation by bridging the Poly(A) tail to the eukaryotic initiation factor 4F complex associated with the mRNA cap. Here, we use unbiased assessment of PABP binding specificity to generate a chemically modified RNA-based competitive inhibitor of PABP. The resulting RNA mimic, which we designated as the Poly(A) SPOT-ON, is more stable than unmodified RNA and binds PABP with high affinity and selectivity in vitro. We show that injection of the Poly(A) SPOT-ON at the site of an injury can attenuate behavioral response to pain. Collectively, these results suggest that PABP is integral for nociceptive plasticity. The general strategy described here provides a broad new source of mechanism-based inhibitors for RNA-binding proteins and is applicable for in vivo studies.
Diagnosis of lysosomal storage disorders: evaluation of lysosome-associated membrane protein LAMP-1 as a diagnostic marker (1997)

Early diagnosis of lysosomal storage disorders (LSDs), before the onset of irreversible pathologies, will be a key factor in the development of effective therapies for many of these disorders. Newborn screening offers a potential mechanism for the early detection of these disorders. From studies of both normal and LSD-affected human skin fibroblasts we identified the lysosome-associated membrane protein LAMP-1 as a potential diagnostic marker. We have developed a sensitive method for the quantification of this protein with a time-resolved fluorescence immunoassay. A soluble form of LAMP-1 was observed in plasma samples, and determination of 152 unaffected individuals gave a median value of 303 micrograms/L with the 5th and 95th percentile at 175 and 448 micrograms/L respectively. Plasma samples from 320 LSD-affected individuals representing 25 different disorders were assayed. We observed that 17 of the 25 disorder groups tested had > 88% of individuals above the 95th percentile of the control population, with 12 groups having 100% above the 95th percentile. Overall, 72% of patients had LAMP-1 concentrations above the 95th percentile of the unpartitioned control population. We suggest that LAMP-1 may be a useful marker in newborn screening for LSDs.
Two-dimensional transforms for device color correction and calibration (2005)

Color device calibration is traditionally performed using one-dimensional (1-D) per-channel tone-response corrections (TRCs). While 1-D TRCs are attractive in view of their low implementation complexity and efficient real-time processing of color images, their use severely restricts the degree of control that can be exercised along various device axes. A typical example is that per separation (or per-channel), TRCs in a printer can be used to either ensure gray balance along the C=M=Y axis or to provide a linear response in delta-E units along each of the individual (C, M, and Y) axis, but not both. This paper proposes a novel two-dimensional color correction architecture that enables much greater control over the device color gamut with a modest increase in implementation cost. Results show significant improvement in calibration accuracy and stability when compared to traditional 1-D calibration. Superior cost quality tradeoffs (over 1-D methods) are also achieved for emulation of one color device on another.
Bovine Leukemia Virus High Tax Molecular Clone Experimentally Induces Leukemia/Lymphoma in Sheep (2005)

Sheep were inoculated with high tax coded pBLV-IF (H group, Nos.1-5) of bovine leukemia virus (BLV), wild tax coded pBLV-IF (W group, Nos. 6-11), or control plasmid (C group, Nos. 12-14). During the observation period (4 to 46 months), 5 of 5 cases in H group and 3 of 6 cases (Nos. 6, 7, 9) in W group became positive for gp 51. Only 1 case in H group became leukemic, and one case each of H and W groups developed lymphoma. In No. 3, lesions were found in multiple organs including the lymph nodes, gastrointestinal tract following abomasum, and heart. In No. 6, lesions of lymphoma were found only in the jejunum and heart. Morphologically, small to middle-sized lymphocytic neoplastic (NP) cells were found in both cases, but lymphoblastic NP cells were found only in No. 3. By immunohistochemical examination, the phenotypes of NP cells were determined as CD1-, CD4-, CD5- -, CD8alpha-, sIgM+, lambda light chain+, B-B4+, MHC class II+ in both case. The results of this study indicate that inoculation of pBLV-IF can induce lymphocytic and lymphoblastic leukemia/lymphoma in sheep. Additionally, it is suggested that the expression rate of tax gene is not associated with the development of leukemia/lymphoma in sheep experimentally inoculated with pBLV-IF.
Lactobacillus GG (LGG) Peptides Can Inhibit Antibiotic-Resistant Bacteria Growth (2010)

Background: We have recently reported that Lactobacillus GG (LGG) elaborates seven small peptides that exert both anti- Gram-negative and Gram-positive bactericidal activity. Among them, peptides NPSRQERR, VHTAPK and PDENK have higher activity than others. Here we further report the inhibitory function of these three peptides on antibiotic- resistant bacterial strains and preliminary structure-activity analysis. Methods: Peptides were synthesized, purified, and dissolved in related media. Lactobacillus GG conditioned medium was used as a positive control and media alone or homologous-conditioned medium were used as negative controls. A600 measurement was used to measure antibacterial activity. Results: LGG-derived peptides NPSRQERR, VHTAPK and PDENK were found to inhibit growth of kanamycin-resistant E. coli SM10 δpir and tetracycline-resistant E. coli TOPO10. Moreover, growth of methicillin-resistant Staphylococcus aureus (MRSA) was also found to be inhibited by peptides NPSEQERR, VHTAPK and PDENK. Structurefunction analyses revealed that the anti-bacterial properties of these peptides can be increased or decreased by modification of amino acid charge.
NMR Characterization of the Aliphatic β/β Pairing for Recognition of A·T/T·A Base Pairs in the Minor Groove of DNA (1999)

Polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids can be combined in antiparallel side-by-side dimeric complexes for sequence-specific recognition in the minor groove of DNA. Because the curvature of four or five contiguous Im−Py rings does not perfectly match the canonical B-helix, β-alanine (β) residues have been inserted to reset the register. Complexes of three pyrrole−imidazole polyamides of sequence composition ImPyPy-X-PyPyPy-Dp, where X = Py, β, or glycine (G), bound to a 13 base pair DNA duplex containing a 9 base pair 5‘-TGTATATCA-3‘ match site were characterized by NMR. NMR titrations and NOESY data combined with restrained molecular modeling show that each polyamide adopts an extended antiparallel dimeric conformation with the ligands fully overlapped around a central Py/Py, G/G, or β/β pair. Conformational exchange is seen near the linker for the G-linked complex, but not with the β or Py linkers. In addition to providing the first direct structural evidence for formation of the aliphatic β/β pairing in the minor groove, models support the idea that the β linker of ImPyPy-β-PyPyPy-Dp provides an optimal combination of size, flexibility, and alignment of the polyamide-paired aromatic subunits in extended, dimeric 2:1 complexes.
Applying Acoustic Emission to Large Format Additive Manufacturing (2022)

Large format additive manufacturing (AM) is being adapted as a method of producing large structures in a short lead time and cost-effective way. With the growing advancement in AM techniques and application, machine monitoring and part qualification is highly needed. There has been leading research focused on the manufacturing development and feedstock material but minimum research on the structural health monitoring (SHM), defect detection, and nondestructive evaluation (NDE) for large format AM. Scanning large structure using conventional nondestructive testing (NDT) techniques, such as ultrasound or X-ray, and searching for potential defects can be very time consuming, challenging and cost prohibitive. Acoustic emission (AE) is a passive technique that can be used to monitor and locate defect progression in large structures by distributing group of sensors around the part. This research outlines the necessary procedure for implementing AE to AM as a reliability method. The topics this research will display are: (a) Wave propagation/velocity evaluation, (b) an AE attenuation characterization for the anisotropic printed structure and material, (c) background noise measurements of the extruder and gantry system, and (d) assist in optimal sensor selection and placement for monitoring large AM structures with demonstration. This work establishes the foundation for scaling up the SHM-AE system for the large additive platform.
Highly efficient narrowband terahertz generation driven by a two-spectral-line laser in PPLN (2021)

We demonstrate record conversion efficiencies of up to~0.9% for narrowband (<1% relative bandwidth) THzgeneration by strongly-cascaded difference frequencygeneration. These results are achieved using a novel lasersource, customized for high efficiencies, with two narrowspectral lines of variable separation and pulse duration(≥250 ps). THz generation in 5% MgO doped periodicallypoledlithium niobate (PPLN) crystals of varying polingperiod was explored at cryogenic and room temperatureoperation as well as different crystal lengths. This workaddresses an increasing demand for high-field THz pulseswhich has, up to now, been largely limited by low opticalto-THz conversion efficiencies.
Strain improvement of Rhizopus oryzae for production of l(+)-lactic acid and glucoamylase (1994)

Journal Article Strain improvement of Rhizopus oryzae for production of l(+)‐lactic acid and glucoamylase Get access W. Suntornsuk, W. Suntornsuk Department of Food Science and Technology, Cornell University, Geneva, NY, USA Search for other works by this author on: Oxford Academic Google Scholar Y.D. Hang Y.D. Hang Department of Food Science and Technology, Cornell University, Geneva, NY, USA Y.D. Hang, Department of Food Science and Technology, Cornell University, Geneva, NY 14456, USA. Search for other works by this author on: Oxford Academic Google Scholar Letters in Applied Microbiology, Volume 19, Issue 4, 1 October 1994, Pages 249–252, https://doi.org/10.1111/j.1472-765X.1994.tb00956.x Published: 01 October 1994 Article history Received: 15 March 1994 Accepted: 11 May 1994 Published: 01 October 1994
An Improved Multimodal Dimension Emotion Recognition Based on Different Fusion Methods (2020)

Continuous emotion recognition is a challenging task and a key part of human-computer interaction, especially multimodal emotion recognition can effectively improve the accuracy and robustness of recognition. But there are limited emotion data sets, and it is difficult to extract emotion features. We present a multi-level segmented decision level fusion emotion recognition model to improve the performance of emotion recognition. In this paper, we predict multi-modal dimensional emotional state on AVEC2017 dataset. Our model uses Bidirectional Long Short-Term Memory (BLSTM) as multi-level segmented emotional feature learning model, and uses the SVR model as fusion model of the decision layer. The BLSTM can model different forms of emotional information in time, and can also consider the impact of previous and later emotional features on current results. The SVR model can compensate for the redundant information of emotion recognition. At the same time, we also consider annotation delay and temporal pooling in our multi-modal dimensional emotion recognition model. Our multi-modal emotion recognition model achieves significant recognition improvements and provide the robustness. Finally, we compare the baseline methods which used the same dataset, and find that the CCC performance of our method is the best on arousal, which is 0.685. Our research shows that the proposed multi-layer segmentation decision level fusion emotion recognition model is conducive to improving performance.
XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia (2019)

β-thalassemia major (β-TM) is an inherited hemoglobinopathy caused by a quantitative defect in the synthesis of β-globin chains of hemoglobin, leading to the accumulation of free a-globin chains that aggregate and cause ineffective erythropoiesis. We have previously demonstrated that terminal erythroid maturation requires a transient activation of caspase-3 and that the chaperone Heat Shock Protein 70 (HSP70) accumulates in the nucleus to protect GATA-1 transcription factor from caspase-3 cleavage. This nuclear accumulation of HSP70 is inhibited in human β-TM erythroblasts due to HSP70 sequestration in the cytoplasm by free a-globin chains, resulting in maturation arrest and apoptosis. Likewise, terminal maturation can be restored by transduction of a nuclear-targeted HSP70 mutant. Here we demonstrate that in normal erythroid progenitors, HSP70 localization is regulated by the exportin-1 (XPO1), and that treatment of β-thalassemic erythroblasts with an XPO1 inhibitor increased the amount of nuclear HSP70, rescued GATA-1 expression and improved terminal differentiation, thus representing a new therapeutic option to ameliorate ineffective erythropoiesis of β-TM.