gebhart/patrepeval huggingface dataset:
Multiple Sclerosis: MicroRNA Expression Profiles Accurately Differentiate Patients with Relapsing-Remitting Disease from Healthy Controls (2009)

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, which is heterogenous with respect to clinical manifestations and response to therapy. Identification of biomarkers appears desirable for an improved diagnosis of MS as well as for monitoring of disease activity and treatment response. MicroRNAs (miRNAs) are short non-coding RNAs, which have been shown to have the potential to serve as biomarkers for different human diseases, most notably cancer. Here, we analyzed the expression profiles of 866 human miRNAs. In detail, we investigated the miRNA expression in blood cells of 20 patients with relapsing-remitting MS (RRMS) and 19 healthy controls using a human miRNA microarray and the Geniom Real Time Analyzer (GRTA) platform. We identified 165 miRNAs that were significantly up- or downregulated in patients with RRMS as compared to healthy controls. The best single miRNA marker, hsa-miR-145, allowed discriminating MS from controls with a specificity of 89.5%, a sensitivity of 90.0%, and an accuracy of 89.7%. A set of 48 miRNAs that was evaluated by radial basis function kernel support vector machines and 10-fold cross validation yielded a specificity of 95%, a sensitivity of 97.6%, and an accuracy of 96.3%. While 43 of the 165 miRNAs deregulated in patients with MS have previously been related to other human diseases, the remaining 122 miRNAs are so far exclusively associated with MS. The implications of our study are twofold. The miRNA expression profiles in blood cells may serve as a biomarker for MS, and deregulation of miRNA expression may play a role in the pathogenesis of MS.
Lipidated promiscuous peptide augments the expression of MHC-II molecules on dendritic cells and activates T cells. (2013)

The findings suggest that L91 evokes maturation and upregulation of MHC class II molecules and promotes better antigen presentation and, therefore, optimum activation of T cells. L91 mainly induces effector Th1 cells, as evidenced by predominant release of IFN-γ, consequently can mount favourable immune response against M. tuberculosis . As L91 does not provoke the generation of anti-peptide antibodies, there is no fear of the efficacy of the vaccine being neutralized by pre-existing anti-mycobacterial antibodies in TB-endemic population. In conclusion, L91 may be considered as a future potential candidate vaccine against TB.
Safe high energy density battery. [Li/tetrabutylammonium bromine/Br] (1979)

This patent covers a safe high energy density battery which includes a lithium anode, a catholyte of bromine, and an electrolyte of tetrabutylammonium bromine.
Minimum mean squared error based warped complex cepstrum analysis for statistical parametric speech synthesis (2013)

This paper presents an approach for complex cepstrum analysis based on the minimum mean squared error criterion, and describes its application to statistical parametric speech synthesis. The proposed method alleviates some of the issues associated with conventional complex cepstrum analysis, such as choice of the window, phase unwrapping, and the need for accurate pitch marks. Given initial estimates of warped complex cepstra and respective analysis instants, the method iteratively optimizes the complex cepstrum on a warped quefrency domain by minimizing the mean squared error between the natural and the reconstructed speech waveforms. When applied to statistical parametric speech synthesis, the optimized complex cepstrum results in better performance in terms of synthesized speech quality, specially for emotional databases, when compared with the complex cepstrum calculated through conventional methods. Copyright © 2013 ISCA.
Synchronization of Micromechanical Oscillators using Light (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. Wiederhecker, "Synchronization of Micromechanical Oscillators using Light," in Latin America Optics and Photonics Conference, OSA Technical Digest (online) (Optica Publishing Group, 2012), paper LM4A.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Response to Comment on Pinsker et al. Randomized Crossover Comparison of Personalized MPC and PID Control Algorithms for the Artificial Pancreas. Diabetes Care 2016;39:1135–1142 (2016)

We thank Dr. Steil (1) for critically reviewing our study comparing model predictive control (MPC) and proportional integral derivative (PID) control for the artificial pancreas (2). We agree that MPC and PID both come in many variants and that there are many successful trials of PID control for automated insulin delivery. We acknowledged in our study that both controllers performed very well overall, even after the 65-g unannounced meal was accounted for, and did so with low rates of hypoglycemia.

We recognize the value in comparing results across different studies and want to emphasize that we did not intend to dismiss studies with different designs. However, it is not possible to have an equitable comparison of MPC versus PID controllers through such meta-analyses. Our study was specifically designed for as fair and balanced a comparison as possible between the …
Adaptive Evolution for the Improvement of Ethanol Production During Alcoholic Fermentation with the Industrial Strains of Yeast Saccharomyces Cerevisiae (2020)

Abstract—Ethanol is one of the most important biotechnological compounds widely used in medicine, pharmacology, food and fuel, cosmetology, and other fields. The main method for ethanol production is alcoholic fermentation using baker’s yeast Saccharomyces cerevisiae. S. cerevisiae converts glucose into ethanol very efficiently: ethanol yield is more than 90% of the theoretical maximum. However, even a slight increase in ethanol yield in an industrial-scale alcoholic fermentation can produce an additional 100 million t of ethanol each year. In this study, the method of adaptive evolution was used to increase the production of ethanol with industrial S. cerevisiae strains: yeast cells were exposed to long-term cultivation on the medium with high concentrations of glucose and ethanol. Most of the adapted strains obtained were characterized by increased ethanol production during alcoholic fermentation in comparison with the original strains.
Low noise characteristics of V-channeled substrate inner stripe laser in single-longitudinal-mode operation (1984)

Stabilization of the single-longitudinal mode of the V-channeled substrate inner stripe (VSIS) laser is attained by coating multidielectric films with high reflectivity on both facets. VSIS lasers with high-reflectivity mirrors are confirmed to have stable spectral characteristics and low noise characteristics. Consequently, in these lasers, the ratio of the lasing mode to the strongest nonlasing mode intensity is ~1250:1, and mode competition noise is suppressed at a temperature of more than 75°C; feedback-induced noise is also repressed up to 0.5% feedback at 3-mW constant output power by automatic power control. A SNR of 110 dB is attained at 1 MHz with 10-kHz bandwidth.
Preparation and characterization of superconducting bismuth lead strontium calcium copper oxides[(Bi,Pb)2Sr2Ca2Cu3] oxides with Tc above 110 K by coprecipitation in triethylamine media (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and characterization of superconducting bismuth lead strontium calcium copper oxides[(Bi,Pb)2Sr2Ca2Cu3] oxides with Tc above 110 K by coprecipitation in triethylamine mediaC. Y. Shei, R. S. Liu, C. T. Chang, and P. T. WuCite this: Inorg. Chem. 1990, 29, 17, 3117–3119Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/ic00342a012https://doi.org/10.1021/ic00342a012research-articleACS PublicationsRequest reuse permissionsArticle Views83Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Model Test of a 1:8-Scale Floating Wind Turbine Offshore in the Gulf of Maine1 (2015)

A new floating wind turbine platform design called VolturnUS developed by the University of Maine uses innovations in materials, construction, and deployment technologies such as a concrete semisubmersible hull and a composite tower to reduce the costs of offshore wind. These novel characteristics require research and development prior to full-scale construction. This paper presents a unique offshore model testing effort aimed at derisking full-scale commercial projects by providing scaled global motion data, allowing for testing of materials representative of the full-scale system, and demonstrating full-scale construction and deployment methods. A 1:8-scale model of a 6 MW semisubmersible floating wind turbine was deployed offshore Castine, ME, in June 2013. The model includes a fully operational commercial 20 kW wind turbine and was the first grid-connected offshore wind turbine in the U.S. The testing effort includes careful selection of the offshore test site, the commercial wind turbine that produces the correct aerodynamic thrust given the wind conditions at the test site, scaling methods, model design, and construction. A suitable test site was identified that produced scaled design load cases (DLCs) prescribed by the American Bureau of Shipping (ABS) Guide for Building and Classing Floating Offshore Wind Turbines. A turbine with a small rotor diameter was selected because it produces the correct thrust load given the wind conditions at the test site. Some representative data from the test are provided in this paper. Model test data are compared directly to full-scale design predictions made using coupled aeroelastic/hydrodynamic software. Scaled VolturnUS performance data during DLCs show excellent agreement with full-scale predictive models. Model test data are also compared directly without scaling against a numerical representation of the 1:8-scale physical model for the purposes of numerical code validation. The numerical model results compare favorably with data collected from the physical model.
Nonopsonic phagocytosis of <i>Pseudomonas aeruginosa</i> requires facilitated transport of <scp>d</scp> -glucose by macrophages. (1995)

Pseudomonas aeruginosa is the predominant respiratory tract pathogen in patients with cystic fibrosis (CF), and its resistance to phagocytosis may contribute to its virulence. P. aeruginosa ingestion by macrophages occurs only in the presence of D-glucose or D-mannose, sugars present in low concentrations in the endobronchial space. Here we show that only isolates of P. aeruginosa and not other bacterial species were ingested by murine macrophages in a glucose-dependent manner. Glucose transport inhibitors blocked both [3H]-2-deoxy-glucose (2dG) uptake and phagocytosis of P. aeruginosa. P. aeruginosa pretreated with 2dG or 5-thio-D-glucose (5TG) was efficiently ingested. Macrophages pretreated with 2dG or 5TG were able to bind but unable to ingest P. aeruginosa in the presence of glucose; however, they efficiently ingested zymosan or IgG-coated sheep erythrocytes. Macrophages produced lactate only from glucose or mannose. The facilitative glucose transporter GLUT1 mRNA transcript was detected by PCR in preparations from purified macrophages. The nucleotide sequence of the PCR product was identical to that published for murine GLUT1. GLUT1 protein was detected with anti-GLUT1-peptide polyclonal Abs. We conclude that glucose exerts its effect on the macrophage, not on the bacterium, in the glucose-dependent nonopsonic phagocytosis of P. aeruginosa and that glucose transport via GLUT1 by the macrophages is required to trigger ingestion. The unique glucose dependency for phagocytosis of P. aeruginosa by macrophages may contribute to the pathogenicity of this bacterial species in CF patients.
A surface code quantum computer in silicon (2015)

The exceptionally long quantum coherence times of phosphorus donor nuclear spin qubits in silicon, coupled with the proven scalability of silicon-based nano-electronics, make them attractive candidates for large-scale quantum computing. However, the high threshold of topological quantum error correction can only be captured in a two-dimensional array of qubits operating synchronously and in parallel-posing formidable fabrication and control challenges. We present an architecture that addresses these problems through a novel shared-control paradigm that is particularly suited to the natural uniformity of the phosphorus donor nuclear spin qubit states and electronic confinement. The architecture comprises a two-dimensional lattice of donor qubits sandwiched between two vertically separated control layers forming a mutually perpendicular crisscross gate array. Shared-control lines facilitate loading/unloading of single electrons to specific donors, thereby activating multiple qubits in parallel across the array on which the required operations for surface code quantum error correction are carried out by global spin control. The complexities of independent qubit control, wave function engineering, and ad hoc quantum interconnects are explicitly avoided. With many of the basic elements of fabrication and control based on demonstrated techniques and with simulated quantum operation below the surface code error threshold, the architecture represents a new pathway for large-scale quantum information processing in silicon and potentially in other qubit systems where uniformity can be exploited.
Synthesis and Characteristic of Spiro-oxazine Compounds. (1991)

The recent results concerning the synthesis and characteristic of spiro-oxazine compounds have been summarized.
Abstract S08-01: Highly sensitive and full-genome interrogation of SARS-CoV-2 using multiplexed PCR enrichment followed by next-generation sequencing (2020)

Abstract Many detection methods have been used or reported for the diagnosis and/or surveillance of COVID-19. Among them, reverse transcription polymerase chain reaction (RT-PCR) is the most commonly used because of its high sensitivity, typically claiming detection of about 5 copies of viruses. However, it has been reported that only 47-59% of the positive cases were identified by some RT-PCR methods, probably due to low viral load, timing of sampling, degradation of virus RNA in the sampling process, or possible mutations spanning the primer binding sites. Therefore, alternative and highly sensitive methods are imperative. With the goal of improving sensitivity and accommodating various application settings, we developed a multiplex-PCR-based method comprising 343 pairs of specific primers and demonstrated its efficiency at detecting SARS-CoV-2 at low copy numbers. The assay produced clean characteristic target peaks of defined sizes, which allowed for direct identification of positives by electrophoresis. We further amplified the entire SARS-CoV-2 genome from 8 to half a million viral copies purified from 13 COVID-19 positive specimens and detected mutations through next-generation sequencing. Finally, we developed a multiplex-PCR-based metagenomic method in parallel that required modest sequencing depth for uncovering SARS-CoV-2 mutational diversity and potentially novel or emerging isolates. Citation Format: Chenyu Li, David N. Debruyne, Julia Spencer, Vidushi Kapoor, Lily Y. Liu, Bo Zhou, Utsav Pandey, Moiz Bootwalla, Dejerianne Ostrow, Dennis T. Maglinte, David Ruble, Alex Ryutov, Lishuang Shen, Lucie Lee, Rounak Feigelman, Grayson Burdon, Jeffrey Liu, Alejandra Oliva, Adam Borcherding, Hongdong Tan, Alexander E. Urban, Xiaowu Gai, Jennifer Dien Bard, Guoying Liu, Zhitong Liu. Highly sensitive and full-genome interrogation of SARS-CoV-2 using multiplexed PCR enrichment followed by next-generation sequencing [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2020 Jul 20-22. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(18_Suppl):Abstract nr S08-01.
A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men (2015)

Evaluation of cancer genomes in global context is of great interest in light of changing ethnic distribution of the world population. We focused our study on men of African ancestry because of their disproportionately higher rate of prostate cancer (CaP) incidence and mortality. We present a systematic whole genome analyses, revealing alterations that differentiate African American (AA) and Caucasian American (CA) CaP genomes. We discovered a recurrent deletion on chromosome 3q13.31 centering on the LSAMP locus that was prevalent in tumors from AA men (cumulative analyses of 435 patients: whole genome sequence, 14; FISH evaluations, 101; and SNP array, 320 patients). Notably, carriers of this deletion experienced more rapid disease progression. In contrast, PTEN and ERG common driver alterations in CaP were significantly lower in AA prostate tumors compared to prostate tumors from CA. Moreover, the frequency of inter-chromosomal rearrangements was significantly higher in AA than CA tumors. These findings reveal differentially distributed somatic mutations in CaP across ancestral groups, which have implications for precision medicine strategies.
Nucleophilic Thiols Reductively Cleave Ether Linkages in Lignin Model Polymers and Lignin (2020)

Lignin may serve as a renewable feedstock for the production of chemicals and fuels if mild, scalable processes for its depolymerization can be devised. The use of small organic thiols represents a bioinspired strategy to cleave the β-O-4 bond, the most common linkage in lignin. In the present study, synthetic β-O-4 linked polymers were treated with organic thiols, yielding up to 90 % cleaved monomer products. Lignin extracted from poplar was also treated with organic thiols resulting in molecular weight reductions as high as 65 % (M<sub>n</sub> ) in oxidized lignin. Thiol-based cleavage of other lignin linkages was also explored in small-molecule model systems to uncover additional potential pathways by which thiols might depolymerize lignin. The success of thiol-mediated cleavage on model dimers, polymers, and biomass-derived lignin illustrates the potential utility of small redox-active molecules to penetrate complex polymer matrices for depolymerization and subsequent valorization of lignin into fuels and chemicals.
Temporal synchronization of multiple audio signals (2014)

Given the proliferation of consumer media recording devices, events often give rise to a large number of recordings. These recordings are taken from different spatial positions and do not have reliable timestamp information. In this paper, we present two robust graph-based approaches for synchronizing multiple audio signals. The graphs are constructed atop the over-determined system resulting from pairwise signal comparison using cross-correlation of audio features. The first approach uses a Minimum Spanning Tree (MST) technique, while the second uses Belief Propagation (BP) to solve the system. Both approaches can provide excellent solutions and robustness to pairwise outliers, however the MST approach is much less complex than BP. In addition, an experimental comparison of audio features-based synchronization shows that spectral flatness outperforms the zero-crossing rate and signal energy.
Synthesis of Epoxy-Functional Microspheres by Cationic Suspension Photopolymerization (2004)

This article describes the development of a novel rapid one-step cationic suspension photopolymerization method for the synthesis of epoxy-functional polymeric microspheres ranging in size from 50 nm to 100 μm. Multifunctional silicon-containing epoxy monomers and oligomers were photopolymerized to produce microspheres in both in aqueous and nonaqueous suspensions using a variety of cationic photoinitiators. Various solvents with controlled polarities were employed to produce macroporous particles. The effects of a variety of experimental and compositional variables on the particle diameter, size distribution, and epoxy content of the microspheres were examined. Among the parameters that were evaluated were the initiator composition and concentration, agitation method, UV irradiation time, viscosities of both the monomer and suspending medium, and type of porogen used. Following synthesis, the microspheres were characterized by SEM microscopy and by titration to determine the epoxy-functional group content. Microspheres that were subjected to pyrolysis at 700 °C retained their macrostructure despite undergoing a 60% weight loss.
Protection of the small intestine against irradiation by means of a removable prosthesis. (1991)

In radiation therapy of tumors, several techniques are used to prevent injury of the intestinal loops. Their purpose is to drive the intestine out of the external beam. Understanding the disadvantages they present, a temporary prosthesis which effectively protects the small bowel, and is easy to remove, has been developed. The device is a 600 to 1,000 ml, silicone rubber, expandable balloon. When implanted in the pelvis or retroperitoneal cavity, and filled, this balloon displaces the intestinal loops out of the pelvic irradiation field. It may remain either filled or empty between each irradiation session. Due to its particular elliptical shape, once empty, the balloon can be removed through a 3 cm incision under local or peridural anesthesia at the completion of radiotherapy. Eleven patients with recurrent (8) or primary (3) cancer have been implanted. The protective effect has been evaluated on successive biologic tests, performed during treatment. No problem related to the prosthesis, no alteration of the biologic tests, nor bowel injury have been observed after several months follow-up. This device is suitable for preventing intestinal complications during therapy, allowing a higher dose of radiations in some cases.