gebhart/patrepeval huggingface dataset:
Abstract 2174: MLL3 act as a tumor suppressor gene in pancreatic cancer (2012)

Abstract Myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3) is a histone 3-lysine 4 methyltransferase, found frequently mutated in a variety of solid tumors, including pancreatic ductal adenocarcinoma where it is the fourth most common somatically mutated gene (excluding homozygous deletions). Despite various somatic mutations, the functional role of MLL3 has not been studied in pancreatic cancer. Upon careful compilation of all the known MLL3 somatic mutations in various solid tumors, no hotspots were identified. However, regardless of the mutation status, we found significantly diminished MLL3 expression in a panel of patient-derived pancreatic tumor cell lines, tumor xenografts and archived patient tumors. Examination of the MLL3 promoter region revealed a CpG island. Methylation of the promoter region was confirmed by methylation-specific PCR in majority of the tumor cell lines and xenografts. Treatment with DNA methyltransferase inhibitor relieved the promoter methylation causing increase in MLL3 transcript expression. Further, knockdown of MLL3 by siRNA in cell lines increased anchorage-independent growth, and enhanced the migration/invasion phenotype of cancer cells. Agilent microarray analysis of two pancreatic cancer cell lines subsequent to knockdown of residual MLL3 function by siRNA, revealed a battery of potential gene targets and pathways regulated by MLL3. The most common Gene Ontology (GO) categories for differentially expressed genes include those involved in cell cycle, cell migration, and DNA repair, underscoring the phenotypes observed with MLL3 siRNA. We indeed observed an increase in MLL3 expression upon DNA damage which was independent of p53 status. Using transgenic mouse model of pancreatic cancer, we are investigating whether loss of MLL3 function in exocrine pancreas cooperates with mutant Kras to accelerate the progression of pancreatic intraepithelial neoplasia (PanIN) to invasive neoplasia. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2174. doi:1538-7445.AM2012-2174
The Therapeutic effect of Memantine through the Stimulation of Synapse Formation and Dendritic Spine Maturation in Autism and Fragile X Syndrome (2012)

Although the pathogenic mechanisms that underlie autism are not well understood, there is evidence showing that metabotropic and ionotropic glutamate receptors are hyper-stimulated and the GABAergic system is hypo-stimulated in autism. Memantine is an uncompetitive antagonist of NMDA receptors and is widely prescribed for treatment of Alzheimer's disease treatment. Recently, it has been shown to improve language function, social behavior, and self-stimulatory behaviors of some autistic subjects. However the mechanism by which memantine exerts its effect remains to be elucidated. In this study, we used cultured cerebellar granule cells (CGCs) from Fmr1 knockout (KO) mice, a mouse model for fragile X syndrome (FXS) and syndromic autism, to examine the effects of memantine on dendritic spine development and synapse formation. Our results show that the maturation of dendritic spines is delayed in Fmr1-KO CGCs. We also detected reduced excitatory synapse formation in Fmr1-KO CGCs. Memantine treatment of Fmr1-KO CGCs promoted cell adhesion properties. Memantine also stimulated the development of mushroom-shaped mature dendritic spines and restored dendritic spine to normal levels in Fmr1-KO CGCs. Furthermore, we demonstrated that memantine treatment promoted synapse formation and restored the excitatory synapses to a normal range in Fmr1-KO CGCs. These findings suggest that memantine may exert its therapeutic capacity through a stimulatory effect on dendritic spine maturation and excitatory synapse formation, as well as promoting adhesion of CGCs.
Optimierung der Förderrate einer piezoelektrischen Hochleistungs-Mikropumpe (2011)

p max (bei V = 0) angegeben.Die Konstanz der Frderrate (Frderratengenauigkeit) wird bei Mikropumpen bisher nicht spezifiziert.Temperaturnderungen oder
You Will Succeed or Not? Matching Prediction in a Marriage Consulting Service (2017)

On online dating websites, a match is accomplished only when two users have mutual interests. Directed contact is a sign of users' interest and our research intends to provide recommendations by predicting whether two users will have reciprocal contact. We learn matching patterns by supervised machine learning and evaluate our framework on a large dataset extracted from a popular dating website. We propose a novel computational pipeline to extract features from both users' profiles and dating social networks to know users' basic information and their preferences. Our results show that both profile-based features and graph-based features can be used to effectively predict whether two users are likely to make reciprocal contact. Best results are achieved when using all of the features as the input to a Support Vector Machine (SVM) and its Matthews correlation coefficient is 0.372. We also prove that users' facial features provide effective information about them and can be used to predict whether two users match each other.
Visual object tracking based on perceptual hash algorithm (2015)

Visual object tracking (VOT) is one of the most challenging problems in the field of computer vision, which plays a crucial role in many applications, especially in human-computer interaction, surveillance and robotics. This paper investigates the contribution of perceptual hash algorithm (PHA) in visual object tracking, which is to generate a “fingerprint” string for each image, and then compare the fingerprint of different images. The results are closer, which means the pictures are more similar. We use the hash fingerprint to conduct the object tracking. Our results suggest that perceptual hash algorithm attributes provide superior performance for visual object tracking, and effectively improve the image match.
S100 protein positive human breast carcinomas: An immunohistochemical study (1994)

An immunohistochemical study for S100 protein was performed on 95 human breast carcinomas. S100 protein positive carcinoma cells were recognized in 54 cases (57%). The S100 protein positive and negative carcinomas were then compared in terms of stage, histologic type, nuclear grade, appearance of minute calcification, immunoreactivity for estrogen receptor (ER), tumor recurrent pattern, and prognosis. The S100 protein positive cases had a tendency to show a low nuclear grade (P < 0.01). They were also more often seen in the ER positive group. For further analysis of the nature of S100 protein positive carcinoma cells, immunoreactivity for neuron-specific enolase (NSE) and actin was investigated. The positive staining for NSE and actin was seen in 46 cases (48%) and 3 cases (3%), respectively. There was, however, no specific correlation among the S100 protein. NSE, or actin staining. The nature of S100 protein positive carcinoma cells still remains unclear. The S100 protein positive carcinomas, however, exhibit relatively better characteristics.
AfterQC: automatic filtering, trimming, error removing and quality control for fastq data (2017)

Much more than just another new quality control (QC) tool, AfterQC is able to perform quality control, data filtering, error profiling and base correction automatically. Experimental results show that AfterQC can help to eliminate the sequencing errors for pair-end sequencing data to provide much cleaner outputs, and consequently help to reduce the false-positive variants, especially for the low-frequency somatic mutations. While providing rich configurable options, AfterQC can detect and set all the options automatically and require no argument in most cases.
A Performance Analysis of Random Linear Network Coding in Wireless Networks (2011)

최근 무선 환경에서 네트워크 효율성 증대를 위하여 네트워크 코딩에 대한 연구들이 많이 진행되고 있다. 본 논문에서는 무선 환경에서 RLNC를 적용하기 위한 고려사항들을 분석해 본다. 우선 기존의 멀티캐스트에서 사용하는 방식으로 우선 분산 환경에 RLNC에 적용 가능한지 살펴보았다. 시뮬레이션 결과 멀티캐스트에서 사용하는 방식대로 적용한 RLNC에서는 디코딩 실패가 발생하였고, X 구조에서 인코딩과 디코딩을 모두 수행하여 디코딩 실패를 제거한 RLNC는 전송 이득이 많지 않았다. 또한 본 논문에서는 hidden 노드 문제, 코딩 기회 분석, RLNC 오버헤드 등의 무선 환경에서 실제적인 고려사항을 분석해 보았다. Recently, studies for the network coding in the wireless network to achieve improvement of the network capacity are conducted. In this paper, we analysis considerations to apply RLNC in the wireless network. First of all, we verify whether the RLNC method in multicast is applied to distributed wireless network. In simulation results, the decoding failure can occur in the original manner of multicast. In RLNC which conducts encoding and decoding in X topology to gets rid of the decoding failure, the RLNC gain is insignificant. In this paper we also discuss considerations such as the hidden node problem, the occurrence of coding opportunity, and the RLNC overhead which are practical issues in the wireless network.
Monitoring of Vital Signs for Long-Term Survival of Mice under Anesthesia: FIGURE 1. (2011)

INTRODUCTION Anesthesia protocols for mice have been optimized, as described here, to achieve long-term imaging (up to 40 h) and facilitate survival through careful monitoring of the mice during anesthesia. Isoflurane anesthesia is the preferred method, because it can be adjusted quickly as needed during the experiment. Critical for the long survival times under anesthesia is the use of the lowest possible dose of anesthesia, which is identified by corneal reflex and monitoring of breath and heart rate, blood-oxygenation levels, and vascular distension using an oximeter probe. It is critical that the carrier gas for isoflurane is humidified. In addition, it is essential to keep mice warm and to compensate for loss of fluid by supplementing with saline. Alternative approaches rely on injectable anesthetics, which do not require dedicated equipment or high-ventilation rates in the imaging room. However, injectable anesthetics are harder to dose for image sessions of >6-10 h.
Antibacterial Activity of Pinus densiflora Leaf-Derived Components Toward Human Intestinal Bacteria (2002)

The growth-inhibiting effects of Pinus densiflora leaf-derived materials on nine human intestinal bacteria were investigated using the impregnated paper disk method, and their activities were compared with those of 13 commercially available terpenes. The biologically active constituent of the extract of P. densiflora leaf was characterized as the monoterpene (1R)-(+)-α-pinene by various spectroscopic analyses. Responses varied according to bacterial strain, chemicals, and dose. At 10 mg/disk, limonene and (1R)-(+)-α-pinene strongly inhibited the growth of Clostridium perfringens, Staphylococcus aureus, and Escherichia coli, without adverse effects on the growth of five lactic acid-bacteria (Bifidobacterium adolescentis, B. bifidum, B. longum, Lactobacillus acidophilus, and L. casei). Little or no inhibition against seven bacteria was observed with anethole, borneol, camphor, caryophyllene, 1,8-cineole, estragole, linalool, and α-terpineol. Structure-activity relationship revealed that (1R)-(+)-α-pinene had more growth-inhibiting activity against C. perfringens than (1R)-(+)-β-, (1S)-(-)-α-, and (1S)-(-)-β-pinenes. Furthermore, the growth-inhibition against L. casei was much more pronounced in (1R)-(+)-β- and (1S)-(-)-β-pinenes than (1R)-(+)-α- and (1S)-(-)-α-pinenes. These results indicate that the (+)-α form seems to be required against C. perfringens and β form against L. casei for growth-inhibiting activity. Morphologically, most strains of C. perfringens were damaged and disappeared at 5 and 2 mg/disk of (1R)-(+)-α-pinene. Morphological study revealed that (1R)-(+)-a-pinene had more growth-inhibiting activity against C. peifringens than (1R)-(+)-β-, (1S)-(-)-α-, and (1S)-(-)-β-pinenes. As naturally occurring growth-inhibiting agents, the Pinus leaf-derived materials described above could be useful preventive agents against diseases caused by harmful intestinal bacteria such as clostridia.
<i>p</i>-Tolylthiomethyl Isocyanide (2001)

[41514-80-1] C9H9NS (MW 163.26) InChI = 1S/C9H9NS/c1-8-3-5-9(6-4-8)11-7-10-2/h3-6H,7H2,1H3 InChIKey = QQMIHLAKHVCFGH-UHFFFAOYSA-N (synthesis of imidazoles from cyanides;1 conversion of aldehydes and ketones to ketene N,S-acetals2) Physical Data: bp 60 °C/0.001 mmHg. Form Supplied in: ill-smelling colorless liquid, which solidifies at −10 °C; turns yellow on standing. Analysis of Reagent Purity: IR (neat) 2150 cm−1; 1H NMR (CDCl3) δ 4.4 (s, CH2). Preparative Method: prepared by dehydration of N-(p-tolylthiomethyl)formamide in 89% yield.2 Handling, Storage, and Precautions: should be stored at −20 °C. Use in a fume hood.
A 10kV/200A SiC MOSFET module with series-parallel hybrid connection of 1200V/50A dies (2015)

In this paper, an innovative series-parallel hybrid circuit topology with silicon carbide MOSFETs is presented and analyzed. This topology consists of two uniform parts in parallel and each of the parts includes three sub-parts in series. The sub-part contains three primary parts connected in string where each of these primary parts has a parallel of two SiC MOSFETs. These 36 SiC devices are divided into six sub-parts, which are driven by a common driving signal. A 10kV/200A SiC MOSFETs module is fabricated based on this hybrid topology with thirty-six 1200V/50A SiC MOSFET dies. The dynamic switching behavior of the module is analyzed and double-pulse tests have been performed at 5400V/200A. The results show a good switching speed of 100ns in turn-on process and 200ns in turn-off process.
Design Considerations to Reduce Conducted and Radiated EMI (2010)

This work evaluates the effects of conducted and radiated EMI due to improperly designed circuits or printed circuit board (PCB) layouts. Common circuits used in a wide range of electronic devices are evaluated using both good and poor design techniques. Additional evaluations are performed to measure the effects of EMI on cabling used for digital communication or RF purposes. Finally, a consumer product is evaluated which must pass regulatory agency requirements in order to be sold in the consumer market. Potential solutions to common EMI problems are then implemented and discussed. This work will look at individual circuits and evaluate design flaws that contribute the largest amount of radiated emissions. Avoiding poor circuit designs and PCB layout mistakes reduces the amount of radiated emissions from any product. This work discusses the theory of electromagnetics and how it pertains to EMI events, then addresses the practical problems associated with EMI using common circuits to illustrate EMI effects. It is important to understand why EMI related effects are becoming more critical, and to show why EMI problems should be corrected within the design phase.
Evaluation of Longitudinal Joint Construction Techniques for Asphalt Pavements in Tennessee (2010)

Longitudinal joints between lanes of hot-mix asphalt (HMA) pavements are commonly susceptible to moisture damage and other failures. In 2006, the Tennessee Department of Transportation (TDOT) identified longitudinal joint failure as one of the major distresses for local HMA pavements. It was determined necessary to evaluate available practices and technologies to reduce longitudinal joint failure. This paper presents the results from a field project in Tennessee constructed with seven different longitudinal joint construction techniques. These techniques could be divided into three major categories: joint adhesives including an anionic emulsion and a polymerized emulsion commonly used by the TDOT, a hot-applied high-polymer rubber, and a high-polymer emulsion; joint sealers including a polymerized maltene emulsion and a polymerized agricultural oil; and infrared joint heater. Laboratory tests were conducted on the field cores taken from the test sections constructed with these techniques. Based on the different mechanisms of these techniques, the following laboratory tests were employed: air void content, permeability, indirect tensile (IDT) strength, and water absorption tests. Field cores were also scanned with the X-ray computed tomography to investigate the effect of infrared heating on air void distribution. The test results showed general consistency in the joint quality; i.e., the lower the air void content, the lower the permeability and the higher the IDT strength. The infrared heater exhibited the best effectiveness in improving joint quality among all the joint construction techniques used in this study.
Synthesis and chemical hydrolysis of surface‐active esters (2003)

Abstract A series of four homologous pure nonionic surfactants, all monoesters of tetra(ethylene glycol), were synthesized. The ester surfactants varied in the degree of substitution on the α‐carbon of the acyl chain, from no substitution to 2‐methyl, to 2‐ethyl, and on to 2,2‐dimethyl. All surfactants were based on C 8 ‐acids except the 2‐methyl‐substituted, which was based on a C 7 ‐acid. The ester surfactants were characterized by critical micelle concentration (CMC) and cloud point. Base‐catalyzed hydrolysis was investigated by using 1 H NMR and tensiometry. The surfactants showed a pronounced difference in hydrolytic reactivity; the nonsubstituted surfactant was 90 times more reactive than the disubstituted, and the reactivity of the methyl‐substituted surfactant was 14 times more reactive than the ethyl‐substituted. Hydrolysis studies above the CMC revealed that the ester bond of the aggregated surfactant is protected from attack by hydroxide ions; thus, only surfactants in monomeric form are being cleaved.
중국 신진 패션 디자이너의 작품에 나타난 하이브리드 특성 연구 (2020)

Based on the trend of pluralization and globalization the collapse of national borders now is a manifestation of mixed and compromised cultures and societies. It is also emerging as a hybrid fashion in fashion. Hybrid fashion means creating a new image by mixing various cultures beyond the time and space. This study aims to analyze the current state of Chinese fashion design and present its direction by grasping the characteristics of hybrids in the works of rising Chinese fashion designers in the era of pluralization. The research method was literature review and empirical research. According to the selection criteria of new fashion designers, 6 new fashion designers of 5 fashion brands were selected and their total 458 points works were analyzed. The analysis results are as follows. First, most of the time trade-offs were ''past and present'' trade-offs that express Chinese traditional culture and the image of the past with modern design. The trade-offs between ''present and future'' is expressed by mixing print patterns, colors and light with fractal art. Second, spatial trade-offs was expressed in the way of expressing Chinese themes in the composition of western clothing, expressing the Western themes in oriental colors, and inspired by Japanese culture expressed by deconstructionism, Third, the gender mix mainly used dark embroidery on women''s clothing, while the men''s wear showed a delicate feminine charm with a surreal pattern on thin and transparent gauze fabric.
A novel substrate for analyzing Alzheimer's disease γ‐secretase (1999)

Proteolytic processing of Alzheimer's disease amyloid precursor protein (APP) by beta-secretase leads to A4CT (C99), which is further cleaved by the as yet unknown protease called gamma-secretase. To study the enzymatic properties of gamma-secretase independently of beta-secretase, A4CT together with an N-terminal signal peptide (SPA4CT) may be expressed in eukaryotic cells. However, in all existing SPA4CT proteins the signal peptide is not correctly cleaved upon membrane insertion. Here, we report the generation of a mutated SPA4CT protein that is correctly cleaved by signal peptidase and, thus, identical to the APP-derived A4CT. This novel SPA4CT protein is processed by gamma-secretase in the same manner as APP-derived A4CT and might be valuable for the generation of transgenic animals showing amyloid pathology.
Continuous Venovenous Hemofiltration with or without Predilution Regional Citrate Anticoagulation: A Prospective Study (2007)

Regional anticoagulation with citrate-based replacement solution improved filter life compared to anticoagulant-free predilution CVVH. This regimen appeared safe, feasible and without metabolic complications or increased costs.
Photon counting spectral CT: improved material decomposition with K-edge-filtered x-rays (2012)

Photon counting spectral computed tomography (PCSCT) provides material selective CT imaging at a single CT scan and fixed tube voltage. The PCSCT data are acquired in several energy ranges (bins) arranged over the x-ray spectrum. The quasi-monoenergetic CT images are acquired in these energy bins and are used for material decomposition. The PCSCT exhibits inherent limitations when material decomposition is performed using energy bins. For effective material decomposition, the energy bins used for material decomposition should be sufficiently narrow and well separated. However, when narrow bins are used, a large fraction of the detected x-ray counts is lost and statistical noise is increased. Alternatively, the x-ray spectrum can be split into a few larger bins with no gap in between and all detected x-ray photons can be used for material decomposition. However, in this case the energy bins are too wide and not well separated, which results in suboptimal material decomposition. The above contradictory requirements can be resolved if the x-ray photons are physically removed from the regions of the energy spectrum between the energy bins. Such a selective removal can be performed using filtration of the x-ray beam by high-Z filter materials with appropriate positions of K-edge energies. The K-edge filtration of x-rays can, therefore, provide necessary gaps between the energy bins with no dose penalty to the patient. In the current work, we proposed using selective K-edge filtration of x-rays in PCSCT and performed the first experimental investigation of this approach. The PCSCT system included a cadmium zinc telluride semiconductor detector with 2 × 256 pixels and 1 × 1 mm(2) pixel size, and five energy bins. The CT phantom had 14 cm diameter and included contrast elements of iodine, gold and calcifications with clinically relevant concentrations. The tube voltages of 60, 90 and 120 kVp were used. K-edge filters based on Ba (E(k) = 37.44 keV) were used for a 60 kVp tube voltage and Gd (E(k) = 50.24 keV) was used for the 90 and 120 kVp tube voltages, respectively. The material selective CT images were also acquired with conventional Al filtration for comparison. The half-value layers of x-ray beams after K-edge and Al filtration were matched. The mean entrance skin exposure was 280 mR for all tube voltages and filters. The contrast-to-noise ratio (CNR) in material-decomposed images was approximately 30%-50% higher when K-edge filters were used instead of Al filters. It was concluded that K-edge filtration of x-rays provides substantial improvement of the CNR in material-selective PCSCT. Further optimization of K-edge filter materials, tube voltages, detector technology and energy bin settings will provide even higher CNR in decomposed images.