gebhart/patrepeval huggingface dataset:
K-Means Clustering Versus Validation Measures: A Data-Distribution Perspective (2008)

K-means is a well-known and widely used partitional clustering method. While there are considerable research efforts to characterize the key features of the K-means clustering algorithm, further investigation is needed to understand how data distributions can have impact on the performance of K-means clustering. To that end, in this paper, we provide a formal and organized study of the effect of skewed data distributions on K-means clustering. Along this line, we first formally illustrate that K-means tends to produce clusters of relatively uniform size, even if input data have varied "true" cluster sizes. In addition, we show that some clustering validation measures, such as the entropy measure, may not capture this uniform effect and provide misleading information on the clustering performance. Viewed in this light, we provide the coefficient of variation (CV) as a necessary criterion to validate the clustering results. Our findings reveal that K-means tends to produce clusters in which the variations of cluster sizes, as measured by CV, are in a range of about 0.3-1.0. Specifically, for data sets with large variation in "true" cluster sizes (e.g., CV > 1.0), K-means reduces variation in resultant cluster sizes to less than 1.0. In contrast, for data sets with small variation in "true" cluster sizes (e.g., CV < 0.3), K-means increases variation in resultant cluster sizes to greater than 0.3. In other words, for the earlier two cases, K-means produces the clustering results which are away from the "true" cluster distributions.
A Reconfigurable Aperture Antenna Based on Switched Links Between Electrically Small Metallic Patches (2004)

A reconfigurable aperture (RECAP) antenna is described in which a planar array of electrically small, metallic patches are interconnected by switches. The antenna can be reconfigured to meet different performance goals by changing the switches that are open and closed. The switch configuration for a particular goal is determined using an optimizer, such as the genetic algorithm. First, the basic concept for the RECAP antenna is verified by comparing theoretical results with measurements for configurations in which the switches are simply wires connecting the patches. Next, details are given for a prototype antenna in which field-effect transistor based electronic switches are used with optical control. Theoretical results for the prototype antenna are then compared with measurements for cases in which electronic reconfiguration is used to change the bandwidth of operation or steer the pattern of the antenna. Finally, an overview of alternate switch/control strategies, some of which were tested, is given along with suggestions for improving the next generation of this antenna.
Virtual and augmented reality: potential applications in radiology (2020)

The modern-day radiologist must be adept at image interpretation, and the one who most successfully leverages new technologies may provide the highest value to patients, clinicians, and trainees. Applications of virtual reality (VR) and augmented reality (AR) have the potential to revolutionize how imaging information is applied in clinical practice and how radiologists practice. This review provides an overview of VR and AR, highlights current applications, future developments, and limitations hindering adoption.
Chemical cross‐linkers for protein structure studies by mass spectrometry (2012)

The cross-linking approach combined with MS for protein structure determination is one of the most striking examples of multidisciplinary success. Indeed, it has become clear that the bottleneck of the method was the detection and the identification of low-abundance cross-linked peptides in complex mixtures. Sample treatment or chromatography separation partially addresses these issues. However, the main problem comes from over-represented unmodified peptides, which do not yield any structural information. A real breakthrough was provided by high mass accuracy measurement, because of the outstanding technical developments in MS. This improvement greatly simplified the identification of cross-linked peptides, reducing the possible combinations matching with an observed m/z value. In addition, the huge amount of data collected has to be processed with dedicated software whose role is to propose distance constraints or ideally a structural model of the protein. In addition to instrumentation and algorithms efficiency, significant efforts have been made to design new cross-linkers matching all the requirements in terms of reactivity and selectivity but also displaying probes or reactive systems facilitating the isolation, the detection of cross-links, or the interpretation of MS data. These chemical features are reviewed and commented on in the light of the more recent strategies.
Towards a high-capacity digital cellular mobile radio system (1985)

A futuristic mobile communication system is proposed, based on the integration of a high-capacity digital cellular mobile radio system with a packet-switched routing network. Every communication terminal, e. g. a telephone, viewphone or computer, is connected to the fixed part of the local area network (LAN) by short-distance radiocommunication. These terminals are deemed to be `mobiles?, irrespective of whether they are in motion. The propagation frequencies advocated are mainly those in the absorption band A1 (51.4?66 GHz). Oxygen absorption of radiated energy in this band is 14 dB/km, and this characteristic is utilised to formulated microcellular structures that are tailored to suit specific geographical locations. The small size of the microcells ensures that the radiated power levels are low and that the date capacity per area is high, and, as a consequence, vast numbers of users can be accommodated. Although the microcells are shaped to the environment, the transceivers are standardised. All signals are digitised prior to radio transmission, and the fixed part of the LAN must be able to accommodate the huge mobile data rate, as must the main trunk network. Thus we suggest and optical-fibre LAN and packetised routing network to overlay the existing networks. Also considered briefly are noncommunication services, such as automatic vehicular location, integration of the communication network with an adaptive traffic control system, route guidance and the mobile office. The treatment is qualitative.
Current data on IL-17 and Th17 cells and implications for graft versus host disease (2013)

Human interleukin 17 was first described in 1995 as a new cytokine produced primarily by activated T CD4+ cells that stimulate the secretion of IL-6 and IL-8 by human fibroblasts, besides increasing the expression of ICAM-1. Various authors have reported that IL-17A has a role in the protection of organisms against extracellular bacteria and fungi due to the capacity of IL-17A to recruit neutrophils to the areas of infection, evidencing a pathological role in various models of autoimmune diseases, such as experimental autoimmune encephalitis and arthritis. The participation of IL-17A has also been described in the acute rejection of organ transplants and graft versus host disease. However, the greatest revolution in research with IL-17 happened in 2000, when it was proposed that IL-17 cannot be classified as Th1 or Th2, but rather, simply as a new lineage of IL-17-producing T-cells. These findings modified the previously established Th1/Th2 paradigm, leading to the definition of the CD3+ CD4+ Th17 cellular subtype and establishment of a new model to explain the origin of various immune events, as well as its implication in the graft versus host disease that is discussed in depth in this article.
A systematic review and meta-analysis of the efficacy and safety of the interleukin (IL)-12/23 and IL-17 inhibitors ustekinumab, secukinumab, ixekizumab, brodalumab, guselkumab and tildrakizumab for the treatment of moderate to severe plaque psoriasis (2018)

Ustekinumab, secukinumab, ixekizumab, brodalumab, guselkumab, and tildrakizumab were highly efficacious and generally well-tolerated when used as treatments for moderate to severe plaque psoriasis.
Changes in Plasma Kynurenic Acid Concentration in Septic Shock Patients Undergoing Continuous Veno-Venous Haemofiltration (2013)

Kynurenic acid (KYNA) is one of the end products of tryptophan metabolism. The aim of this study was to analyse plasma KYNA concentration in septic shock patients (SSP) with acute kidney injury (AKI) undergoing continuous veno-venous haemofiltration (CVVH). Changes in KYNA content were compared to alterations in the levels of procalcitonin (PCT), C-reactive protein and lactate. Adult SSP with AKI were examined. Measurements were conducted at seven time points: before beginning CVVH and at 6, 12, 24, 48, 72 and 96 h after the beginning of CVVH. Based on clinical outcomes, the data were analysed separately for survivors and non-survivors. Twenty-seven patients were studied. CVVH was associated with reduced plasma KYNA concentration only in survivors. Plasma KYNA concentration correlated with the levels of lactate and PCT only in survivors. (1) CVVH reduced plasma KYNA concentration only in survivors; (2) lack of this reduction may predict fatal outcomes in SSP.
Enhanced<i>in vivo</i>performance of liposomal indomethacin derived from effervescent granule based proliposomes (1995)

Indomethacin, a non-steroidal anti-inflammatory drug was successfully entrapped into liposomes (soyabean lecithin, cholesterol, stearylamine or dicetylphosphate) with uniform size distribution. The liposomal vesicles were derived from dried effervescent granule-based proliposomes. The in vivo distribution characteristics of the reconstituted liposomal indomethacin was studied in normal rats and in the rats with inflamed paws following intravenous administration. The localization of the liposome-based indomethacin was in liver, lungs and inflamed tissues (inflamed rats studies). Further, an enhanced anti-inflammatory activity of lipo-indomethacin was found as compared with the activity recorded for plain drug in carrageenan induced paw oedema in rats.
An active boosting-based learning framework for real-time hand detection (2008)

Human hand detection problem has important applications in sign language and human machine interfaces. In this work, we present a novel approach for learning a vision-based hand detection system. The main contribution is a robust on-line boosting-based framework for real-time detection of a hand in unconstrained environments. The use of efficient representative features allows fast computation while dealing with vast changing of hand appearances and background. Interactive on-line training allows efficiently train and improve the detector. Moreover, we propose a strategy to efficiently improve the performance meanwhile reduce hand labeling effort. Besides, if necessary, we use a verification process to prevent “drifting” of classifier over time. The proposed method is practically favorable as it meets the requirements of real-time performance, accuracy and robustness. It works well with reasonable amount of training samples and is computational efficient. Experiments for detection of hands in challenging data sets show the outperform of our approach.
Molecular Epidemiology of Novel Pathogen “Brachyspira hampsonii” Reveals Relationships between Diverse Genetic Groups, Regions, Host Species, and Other Pathogenic and Commensal Brachyspira Species (2015)

Outbreaks of bloody diarrhea in swine herds in the late 2000s signaled the reemergence of an economically significant disease, swine dysentery, in the United States. Investigations confirmed the emergence of a novel spirochete in swine, provisionally designated "Brachyspira hampsonii," with two genetically distinct clades. Although it has since been detected in swine and migratory birds in Europe and North America, little is known about its genetic diversity or its relationships with other Brachyspira species. This study characterizes B. hampsonii using a newly developed multilocus sequence typing (MLST) approach and elucidates the diversity, distribution, population structure, and genetic relationships of this pathogen from diverse epidemiological sources globally. Genetic characterization of 81 B. hampsonii isolates, originating from six countries, with our newly established MLST scheme identified a total of 20 sequence types (STs) belonging to three clonal complexes (CCs). B. hampsonii showed a heterogeneous population structure with evidence of microevolution locally in swine production systems, while its clustering patterns showed associations with its epidemiological origins (country, swine production system, and host species). The close genetic relatedness of B. hampsonii isolates from different countries and host species highlights the importance of strict biosecurity control measures. A comparative analysis of 430 isolates representing seven Brachyspira species (pathogens and commensals) from 19 countries and 10 host species depicted clustering by microbial species. It revealed the close genetic relatedness of B. hampsonii with commensal Brachyspira species and also provided support for the two clades of B. hampsonii to be considered a single species.
Tailoring Ca-Based Nanoparticles by Polyol Process for Use as Nematicidals and pH Adjusters in Agriculture (2019)

The remarkable progress in nanotechnology has extended the application of inorganic nanoparticles (NPs) in the agriculture sector, as both economically sustainable and environmentally sound alternatives. Root knot nematodes are undoubtedly a foremost problem of agriculture, and research strives to develop effective materials to tackle this issue. Herein, the microwave-assisted selective polyol synthesis of different compositions of Ca-based NPs, Ca(OH)2, Ca(OH)2/CaCO3, and CaCO3 is reported and the products were evaluated as nematicides and pH adjusters. Two precursors (CaCl2 and Ca(NO3)2) and three polyols (1,2-propylene glycol (PG), tetraethylene glycol (TEG), polyethylene glycol (PEG 8000)) that differ in their redox potential have been utilized to provide selectivity over composition. On the basis of the utilized polyols, NPs are produced as inorganic/organic hybrid formulations with a biocompatible organic coating that provides increased colloidal stability and controlled release of active components. Characterization of NPs has been carried out by XRD, TGA, FTIR, TEM, and pH-metry. Each composition exhibited different pH changing ability, an essential feature for agrochemical applications. The in vitro nematicidal activity of Ca(OH)2, Ca(OH)2/CaCO3, and CaCO3NPs was evaluated on second stage juveniles (J2) of two Meloidogyne species (Meloidogyne incognita and Meloidogyne javanica) based on nematode paralysis experiments. Results unveiled nematicidal activity for all evaluated Ca-based NPs, while Ca(OH)2 and CaCO3 NPs appeared to be the most and the least effective ones, respectively. The nematicidal effect appears to be boosted by the release of [OH]− anions, as indicated by pH-metric measurements, displaying the crucial role of [OH]− anions in their nematicidal activity.
Regulation of Transcription Factor Pdr1p Function by an Hsp70 Protein in <i>Saccharomyces cerevisiae</i> (1998)

Multiple or pleiotropic drug resistance in the yeast Saccharomyces cerevisiae requires the expression of several ATP binding cassette transporter-encoding genes under the control of the zinc finger-containing transcription factor Pdrlp. The ATP binding cassette transporter-encoding genes regulated by Pdrlp include PDR5 and YOR1, which are required for normal cycloheximide and oligomycin tolerances, respectively. We have isolated a new member of the PDR gene family that encodes a member of the Hsp70 family of proteins found in this organism. This gene has been designated PDR13 and is required for normal growth. Overexpression of Pdr13p leads to an increase in both the expression of PDR5 and YOR1 and a corresponding enhancement in drug resistance. Pdr13p requires the presence of both the PDR1 structural gene and the Pdr1p binding sites in target promoters to mediate its effect on drug resistance and gene expression. A dominant, gain-of-function mutant allele of PDR13 was isolated and shown to have the same phenotypic effects as when the gene is present on a 2microm plasmid. Genetic and Western blotting experiments indicated that Pdr13p exerts its effect on Pdr1p at a posttranslational step. These data support the view that Pdr13p influences pleiotropic drug resistance by enhancing the function of the transcriptional regulatory protein Pdr1p.
Li-ion Battery Fault Detection in Large Packs Using Force and Gas Sensors (2020)

Internal short circuits are a leading cause of battery thermal runaway, and hence a major safety issue for electric vehicles. An internal short circuit with low resistance is called a hard internal short, which causes a high internal current flow that leads to an extremely fast temperature rise, gas generation, cell swelling, and ultimately battery rupture and failure. Thus it is crucial to detect these faults immediately after they get triggered. In large battery packs with many cells in parallel, detecting an internal short circuit event using voltage is difficult due to suppression of the voltage signal from the faulty cell by the other healthy cells connected in parallel. In contrast, analyzing the gas composition in the pack enclosure can provide a robust single cell failure detection method. At elevated temperature, decomposition of the battery materials results in gas generation and cell swelling. The cell structure is designed to rupture at a critical gas pressure and vent the accumulated $CO_2$ gas, in order to prevent explosive forces. In this paper, we extend our previous work by combining the models of cell thermal dynamics, swelling, and $CO_2$ gas generation. In particular, we developed a fast and high confidence level detection method of hard internal short circuit events for a battery pack by measuring cell expansion force and monitoring $CO_2$ concentrations in a pack enclosure.
Diamond deposition with plasma jet at reduced pressure (1990)

Carburizing and diamond deposition experiments were done on titanium, niobium, and molybdenum substrates with argon-methane-hydrogen gas mixture plasma jets at a pressure of 200 torr for various hydrogen concentrations. Diamond deposition was obtained at a volume of 7% hydrogen added to the plasma jet. The deposits were markedly different on the different metal substrates. Diamond deposits with habit planes were clearly observed on niobium and molybdenum, while the deposit on titanium consisted of ball-like particles. The emission spectra from the plasma jet were the same, for all the substrates, proving that the difference in the diamond deposit depends on the substrate characteristics. CH, C/sub 2/, hydrogen, and carbon atoms were identified in the plasma jet. The difference in the deposits is attributed to the reactivity of carbon species in the plasma with the metal surface as well as to the solubility of hydrogen in metals.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mapping of V beta 11+ helper T cell epitopes on mycobacterial antigen in mouse primed with Mycobacterium tuberculosis (1997)

Antigenic epitopes for Mycobacterium tuberculosis-reactive T cell immune responses have been mapped using the purified Mycobacterium protein antigen. Lymph node cells from C57BL/6 mice that had been immunized with heat-killed M. tuberculosis were cultured with various Mycobacterium protein antigens and their reactivity was monitored by proliferative response. Usage of the TCR beta chain repertoire was analyzed by flow cytometry. Stimulation of M. tuberculosis-primed lymph node cells with MPT59 (antigen 85B, alpha antigen) induced proliferative response, production of IL-2 and IFN-gamma, and the expansion of V beta 11+ CD4+ T cells in conjunction with antigen-presenting cells in an I-Ab-restricted manner. Lymph node cells from non-primed mice failed to proliferate in response to MPT59. Using peptides covering the complete mature 285 amino acids long MPT59 protein as 15-mer molecules overlapping by five amino acids, we identified the antigenic epitope for MPT59-specific V beta 11+ T cells. The 15-mer peptide, covering amino acid residues 240-254 of MPT59 [peptide-25 (amino acids 240-254)], contains the motif that is conserved for I-Ab and requires processing by antigen-presenting cells to trigger peptide-25-specific V beta 11+ CD4+ T cells. We conclude from these results that MPT59 and peptide-25 (amino acids 240-254) are not superantigens and require antigen processing in order to stimulate V beta 11+ Th1 cells. This experimental system will provide us with a useful tool for delineating the regulation of T cell development in a particular subset of M. tuberculosis infection and for developing antigenic peptides for Th1-dominant immune responses.
Metal oxynitrides as emerging materials with photocatalytic and electronic properties (2015)

Metal oxynitrides are intensively investigated as a group of materials to expand and tune the properties of oxides showing emerging applications as photocatalysts, pigments, phosphors, dielectrics and magnetic materials.
Quantum limits on phase-preserving linear amplifiers (2012)

The purpose of a phase-preserving linear amplifier is to make a small signal larger, regardless of its phase, so that it can be perceived by instruments incapable of resolving the original signal, while sacrificing as little as possible in signal-to-noise ratio. Quantum mechanics limits how well this can be done: A high-gain linear amplifier must degrade the signal-to-noise ratio; the noise added by the amplifier, when referred to the input, must be at least half a quantum at the operating frequency. This well-known quantum limit only constrains the second moments of the added noise. Here we derive the quantum constraints on the entire distribution of added noise: We show that any phase-preserving linear amplifier is equivalent to a parametric amplifier with a physical state for the ancillary mode; the noise added to the amplified field mode is distributed according to the Wigner function of the ancilla state.
Design of 2.4-GHz CMOS reconfigurable dual-function switch network and its application on array beamforming (2009)

This paper proposed a 2.4-GHz monolithic switch network, which can be reconfigured with two functionalities, serving as a single-pole-quadruple-throw (SPQT) switch or a 3-dB Wilkinson power divider (PD). The circuit consists of numbers of MOS switches in order to select the desired signal path as well as to terminate the unused ports. In SPQT switch operation, the experimental results show that the insertion and return losses are 2 dB and >15 dB, respectively. For 3-dB Wilkinson PD operation, the measurements exhibit that, with all ports matched to 50 Ω, the return loss and the output ports isolation are better than 19 dB with an insertion loss of ~ 1.6 dB. This circuit is fabricated in 0.18-μm CMOS technology with chip size of 0.78 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (excluding the I/O pads). To demonstrate its applicability, an example of single/twin-fed Butler matrix driven by the proposed device for array beamforming is presented.