gebhart/patrepeval huggingface dataset:
A microfluidic platform integrated with tapered optical fiber for studying resonant properties of compact high index microspheres (2011)

In this work we designed and tested a micro fluidic platform integrated with a tapered fiber for studying resonant properties of a variety of microspheres sizes from 3 μm to 25 μm with different index of refraction from 1.47 to 2.1 in water and air environments. Experiments are performed by reattaching the microspheres along the tapered fibers with the diameter varying from 1 μm to 7 μm. Although the quality factors of whispering gallery modes (WGMs) are usually degraded for compact cavities immersed in liquid due to the reduced index contrasts, we show that this problem can be solved by using cavities made from high index materials. We demonstrated loaded Q-factors approaching ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> for coupling to WGMs in compact (as small as 4 - 5 μm in diameter) barium titanate glass microspheres with refractive indices 1.9 and 2.1. The microfluidic platform developed in this work can be used for studying resonant optical forces exerted on compact microspheres in a liquid as well as for developing compact microsphere resonator sensor devices.
Semantic Business Process Modeling (2010)

This book presents a process-oriented business modeling framework based on semantic technologies. The framework consists of modeling languages, methods, and tools that allow for semantic modeling of business motivation, business policies and rules, and business processes. Quality of the proposed modeling framework is evaluated based on the modeling content of SAP Solution Composer and several real-world business scenarios.
Spectroscopic imaging of bladder cancer (2003)

The feasibility of developing bladder cancer detection methods using intrinsic tissue optical properties is the focus of this investigation. <i>In vitro</i> experiments have been performed using polarized elastic light scattering in combination with tissue autofluorescence in the NIR spectral region under laser excitation in the green and red spectral regions. The experimental results obtained from a set of tissue specimens from 25 patients reveal the presence of optical fingerprint characteristics suitable for cancer detection with high contrast and accuracy. These photonic methods are compatible with existing endoscopic imaging modalities which make them suitable for in-vivo application.
Application of a new high-speed magnetic deformable mirror for in-vivo retinal imaging (2011)

Nowadays in ophthalmologic practice several commercial instruments are available to image patient retinas in vivo. Many modern fundus cameras and confocal scanning laser ophthalmoscopes allow acquisition of two dimensional <i>en face</i> images of the retina with both back reflected as well as fluorescent light. Additionally, optical coherence tomography systems allow non-invasive probing of three-dimensional retinal morphology. For all of these instruments the available lateral resolution is limited by optical quality of the human eye used as the imaging objective. To improve lateral resolution and achieve diffraction-limited imaging, adaptive optics (AO) can be implemented with any of these imaging systems to correct both static and dynamic aberrations inherent in human eyes. Most of the wavefront correctors used previously in AO systems have limited dynamic range and an insufficient number of actuators to achieve diffraction-limited correction of most human eyes. Thus, additional corrections were necessary, either by trial lenses or additional deformable mirrors (DMs). The UC Davis AO flood-illuminated fundus camera system described in this paper has been previously used to acquire in vivo images of the photoreceptor mosaic and for psychophysical studies on normal and diseased retinas. These results were acquired using a DM manufactured by Litton ITEK (DM109), which has 109 actuators arranged in a hexagonal array below a continuous front-surface mirror. It has an approximate surface actuator stroke of ±2μm. Here we present results with a new hi-speed magnetic DM manufactured by ALPAO (DM97, voice coil technology), which has 97 actuators and similar inter-actuator stroke (>3μm, mirror surface) but much higher low-order aberration correction (defocus stroke of at least ±30μm) than the previous one. In this paper we report results of testing performance of the ALPAO DM for the correction of human eye aberrations. Additionally changes made to our AO flood illuminated system are presented along with images of the model eye retina and in-vivo human retina acquired with this system.
Experimental Study on the Forcible Imbibition Law of Water in Shale Gas Reservoirs (2023)

Water imbibition is a key factor affecting the flowback regime of shale gas wells after volume fracturing. In this study, a set of experimental apparatus and corresponding test and evaluation methods were developed to analyze the laws of forcible imbibition of water in a shale reservoir, characterize the initiation time of microfractures induced by shale hydration quantitatively, and optimize the shut-in time of shale gas wells; the imbibition depths of different pore types are quantitatively calculated based on the multiple pore imbibition analytical model. The experimental results show that: according to imbibition saturation growth rate, the shale forcible imbibition can be divided into three periods, imbibition diffusion, imbibition transition, and imbibition balance. Among them, the imbibition diffusion period is the main period for imbibition capacity rise. The reason for this phenomenon is that due to the fluid pressure difference effect, the shale fills its large pores and microfractures rapidly in the early stage, and in the percolation transition period, the percolation rate decreases continuously due to the gradual increase of fluid saturation. Due to the Jamin effect, it is difficult for the fluid to enter the small pores and the fluid fills the pore roar channel, the seepage saturation tends to stabilize, and the seepage equilibrium period appears. In the early period of shut-in, the imbibition capacity of shale increases significantly under the action of fluid pressure, providing a large amount of imbibition fluid for the spontaneous imbibition later. The imbibition depth of a clay pore was much greater than that of a brittle mineral pore and an organic pore. The reservoir confining pressure has prohibition on shale imbibition, but even under reservoir confining pressure, imbibition can still improve the fracturing effect of the reservoir, resulting in an increase in porosity of 0.42–1.63 times and an increase in permeability of 17.6–67.3 times. Under the experimental conditions, the initiation time of induced microfractures is 98.5 h on average and is in negative correlation with imbibition capacity. On this basis, the optimized shortest shut-in time of a shale gas well is 5 days. The study results can provide a scientific basis for the optimization of the flowback regime of shale gas reservoirs.
Trustworthy data from untrusted databases (2012)

Data are often stored at untrusted database servers. The lack of trust arises naturally when the database server is owned by a third party, as in the case of cloud computing. It also arises if the server may have been compromised, or there is a malicious insider. Ensuring the trustworthiness of data retrieved from such untrusted database is of utmost importance. Trustworthiness of data is defined by faithful execution of valid and authorized transactions on the initial data. Earlier work on this problem is limited to cases where data are either not updated, or data are updated by a single trustworthy entity. However, for a truly dynamic database, multiple clients should be allowed to update data without having to route the updates through a central server. In our previous work [5], we proposed solutions to establish authenticity and integrity of data in a dynamic setting where the clients can run transactions directly on the database server. Our solution provides provable authenticity and integrity of data with absolutely no requirement for the server to be trustworthy. Our solutions also provide assured provenance of data. In this demonstration, we present a working prototype of our solution built on top of Oracle with no modifications to the database internals. We show that system can be easily adopted in an existing databases without any internal changes to the database. We also demonstrate how our system can provide authentic provenance.
Optoelectronic loop design with 1000 finesse Fabry-Perot etalon (2010)

A 10.287 GHz optoelectronic oscillator is experimentally demonstrated that uses a 1000 finesse Fabry-Perot etalon as the mode selector instead of an rf filter. The results are compared with a standard optoelectronic loop with an rf filter. The substitution of the rf filter with the optical filter results in a higher rf stability and lower phase noise.
DC Voltage Control Architecture in Renewable Energy Based Three-Level Converters (2019)

The three-level converters with series connected capacitors need to address the dc voltage control and balancing under any conditions, whether in operational or standby. The effect of inrush transients in dc bus results in degradation of components lifetime, resulting in premature failures. To address these issues, we present a new power conversion architecture to economically simplify the subsystems, with the following integrated functionalities: auxiliary dc power supply, lossless dc split-bus balancing and inrush current elimination. These integrated functions are achieved by controlling a bi-directional dc-dc three-level converter topology. The three-level buck-boost (3L-BB) interface converter provides the capability to supply power to various auxiliary loads for the main three-phase three- level converter, while performing dc voltage regulation and balancing. The system initialization feature that precharges the dc split-bus capacitors through 3L-BB eliminates the inrush current, allowing the use of components with longer lifetime at lower cost. The proposed system architecture was evaluated within a 100kW three-phase three-level grid- connected photovoltaic (PV) inverter. The evaluation results demonstrate the architecture's performance for power supply capability with voltage regulation, lossless dc splitbus balancing and inrush current elimination.
Controlled-Load Limited Switch Dynamic Logic Circuit (2005)

Limited switch dynamic logic (LSDL), a high performance logic circuit, has been modified by introducing a pseudo-nMOS style load. The resultant circuit consumes less power, primarily due to the reduction of capacitance on the clock network. The controlled-load LSDL is shown to be more robust to noise and power rail bounce. A 64-bit rotator circuit was used in the analysis. The effect of process variation on circuit performance is also evaluated.
Development of a Reinforced Soil Arch: How to Put the Dirt to Work (2007)

The construction, maintenance and replacement of crossing structures within North America are significant aspects of the transportation infrastructure. Cost effective means of constructing, maintaining and replacing crossings are vital to maintaining the transportation system. Historically, economical crossings were constructed with locally available materials. Where ideal construction materials were not readily available, construction techniques were developed to utilize the local materials. By utilizing the knowledge of the behaviour of reinforced soils with the understanding of soil arching, reinforced soil arches can be constructed using local mineral soil fill reinforced with economical geotextile fabrics. The construction of a 33 m long by 2.4 m wide reinforced soil arch on an industrial log haul road on the north end of Vancouver Island, British Columbia, Canada, demonstrated that significant cost savings can be realized by constructing crossings with reinforced soil arches.
Llama Nanoantibodies with Therapeutic Potential against Human Norovirus Diarrhea (2015)

Noroviruses are a major cause of acute gastroenteritis, but no vaccines or therapeutic drugs are available. Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa with several advantages over conventional antibodies. The aim of this study was to generate recombinant monoclonal VHH specific for the two major norovirus (NoV) genogroups (GI and GII) in order to investigate their potential as immunotherapy for the treatment of NoV diarrhea. To accomplish this objective, two llamas were immunized with either GI.1 (Norwalk-1968) or GII.4 (MD2004) VLPs. After immunization, peripheral blood lymphocytes were collected and used to generate two VHH libraries. Using phage display technology, 10 VHH clones specific for GI.1, and 8 specific for GII.4 were selected for further characterization. All VHH recognized conformational epitopes in the P domain of the immunizing VP1 capsid protein, with the exception of one GII.4 VHH that recognized a linear P domain epitope. The GI.1 VHHs were highly specific for the immunizing GI.1 genotype, with only one VHH cross-reacting with GI.3 genotype. The GII.4 VHHs reacted with the immunizing GII.4 strain and showed a varying reactivity profile among different GII genotypes. One VHH specific for GI.1 and three specific for GII.4 could block the binding of homologous VLPs to synthetic HBGA carbohydrates, saliva, and pig gastric mucin, and in addition, could inhibit the hemagglutination of red blood cells by homologous VLPs. The ability of Nov-specific VHHs to perform well in these surrogate neutralization assays supports their further development as immunotherapy for NoV treatment and immunoprophylaxis.
Gamma-vinyl GABA inhibits methamphetamine, heroin, or ethanol-induced increases in nucleus accumbens dopamine (1999)

We examined the acute effect of the irreversible GABA-transaminase inhibitor, gamma-vinyl GABA (GVG, Sabril((R)), Vigabatrin((R))) on increases in nucleus accumbens (NAc) dopamine (DA) following acute administration of methamphetamine, heroin, or ethanol. Methamphetamine (2.5 mg/kg) produced a dose-dependent increase (2, 700%) in NAc DA. GVG preadministration (300 or 600 mg/kg), however, inhibited this response by approximately 39 and 61%, respectively. The lower dose of methamphetamine (1.25 mg/kg), increased DA by 1, 700%. This response was inhibited to a similar extent (44%) regardless of the GVG dose preadministered (300 or 600 mg/kg). In addition, heroin-induced increases in NAc DA (0.5 mg/kg, 170%) were inhibited or completely abolished by GVG (150 or 300 mg/kg, 65 and 100%, respectively). Finally, at half the dose necessary for heroin, GVG (150 mg/kg) also completely abolished ethanol-induced increases in NAc DA following a 0.25 g/kg challenge dose (140%). Taken with our previous findings using nicotine or cocaine as the challenge drug, these results indicate that GVG attenuates increases in NAc DA by a mechanism common to many drugs of abuse. However, it appears unlikely that an acute dose of GVG can completely inhibit increases in NAc DA following challenges with a drug whose mechanism of action is mediated primarily through the DA reuptake site.
Learning Light Transport the Reinforced Way (2017)

We show that the equations of reinforcement learning and light transport simulation are related integral equations. Based on this correspondence, a scheme to learn importance while sampling path space is derived. The new approach is demonstrated in a consistent light transport simulation algorithm that uses reinforcement learning to progressively learn where light comes from. As using this information for importance sampling includes information about visibility, too, the number of light transport paths with zero contribution is dramatically reduced, resulting in much less noisy images within a fixed time budget.
Data stream warehousing (2013)

tutorial Data stream warehousing Share on Authors: Lukasz Golab University of Waterloo, Waterloo, ON, Canada University of Waterloo, Waterloo, ON, CanadaView Profile , Theodore Johnson AT&T Labs - Research, Florham Park, NJ, USA AT&T Labs - Research, Florham Park, NJ, USAView Profile Authors Info & Claims SIGMOD '13: Proceedings of the 2013 ACM SIGMOD International Conference on Management of DataJune 2013 Pages 949–952https://doi.org/10.1145/2463676.2465337Online:22 June 2013Publication History 2citation603DownloadsMetricsTotal Citations2Total Downloads603Last 12 Months9Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
A new preparative-scale purification technique: pH-zone-refining countercurrent chromatography (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new preparative-scale purification technique: pH-zone-refining countercurrent chromatographyAdrian Weisz, Alan L. Scher, Kazufusa Shinomiya, Henry M. Fales, and Yoichiro ItoCite this: J. Am. Chem. Soc. 1994, 116, 2, 704–708Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ja00081a035https://doi.org/10.1021/ja00081a035research-articleACS PublicationsRequest reuse permissionsArticle Views413Altmetric-Citations119LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An improved probe noise approach for acoustic feedback cancellation (2012)

The perhaps most challenging problem in acoustic feedback cancellation using adaptive filters is the bias problem. It is well-known that a probe noise approach can effectively prevent this problem. However, when the probe noise must be inaudible and the steady-state error of the adaptive filter must be unchanged, this approach causes a significantly decreased convergence rate of the adaptive filter, and might thereby be less useful in practical applications. In this work, we propose a new probe noise approach which significantly increases the convergence rate while maintaining the steady-state error of the adaptive algorithm in a multiple-microphone and single-loud-speaker audio system. This is obtained through a specifically designed probe noise signal and a corresponding probe noise enhancement strategy. We show the effects of the proposed probe noise approach by deriving analytical expressions for its system behavior, and through a simulation experiment in an acoustic feedback cancellation system.
Hydrogen Cyano Fullerene Derivatives as Acid for Proton Conducting Membranes (2008)

The proton conducting nature of hydrogen tricyano fullerene has been characterized for applications in fuel cells. The fullerene alone did not show much proton conductivity itself. However, when mixed in a polymer, it exhibited a high conductivity under low humidity: under the 20% relative humidity. The conductivity was enhanced as the dispersion of the fullerene was improved in the polymer matrix through two fullerene dispersants: and . The computer modeling has been performed to gain insight into the proton conducting mechanism.
Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation (2018)

We previously reported the discovery, validation, and structure-activity relationships of a series of piperidinyl ureas that potently inhibit the DCN1-UBE2M interaction. We demonstrated that compound 7 inhibits both the DCN1-UBE2M protein-protein interaction and DCN1-mediated cullin neddylation in biochemical assays and reduces levels of steady-state cullin neddylation in a squamous carcinoma cell line harboring DCN1 amplification. Although compound 7 exhibits good solubility and permeability, it is rapidly metabolized in microsomal models (CL<sub>int</sub> = 170 mL/min/kg). This work lays out the discovery of an orally bioavailable analogue, NAcM-OPT (67). Compound 67 retains the favorable biochemical and cellular activity of compound 7 but is significantly more stable both in vitro and in vivo. Compound 67 is orally bioavailable, well tolerated in mice, and currently used to study the effects of acute pharmacologic inhibition of the DCN1-UBE2M interaction on the NEDD8/CUL pathway.
New frontiers for high value utilisation offly ash : production of zeolites (1999)

This paper outlines technologies for production of flyash based zeolite (FAZ) A, X & Y with significant reduction in the cost of production of FAZs due to substitution of conventionalraw material, viz. sodium silicate and aluminate with flyash. The cost of production of FAZs is estimated to be 25% lower than the indegenously available commercial zeolites. The high exchange capacity of FAZ-A indicates its potential as a substitute for phosphatic detergent builder. The high surface area and thermal stability of FAZ-Y indicates its suitability as a catalyst in specific areas such as automotive exhaust and detergent.
Silicon Probe Measurement and Characterization in Sub-THz Range (2020)

We propose, investigate, and demonstrate a pure and simple dielectric probe operating in the sub-terahertz range with an example band of interest 190-220 GHz. High-resistivity silicon technology is deployed for this non-TEM mode probe development as it presents a viable low-loss material. A T-shape alignment dowel was used to integrate the silicon probe with the waveguide block. The probe can be used to measure and characterize the low permittivity-based dielectric waveguide transmission line and its building components free from the use of any transition structures and TEM-mode probes. For demonstration, the silicon probe was used to measure a substrate integrated image guide and its components in the range of 190-220 GHz. A substrate integrated image guide (SIIG)-based thru, reflect, and line (TRL) calibration kit was developed, and a two-tier TRL calibration was used to characterize the SIIG.