gebhart/patrepeval huggingface dataset:
A Practical Approach to the Use and Design of Flow Control Devices in SAGD (2017)

Abstract Over the past few years, an increasing number of operators in steam assisted gravity drainage (SAGD) in situ recovery of bitumen in the Alberta Oil Sands are becoming interested in the use of flow control devices (FCDs). Initial field trials by some operators of these devices have shown promise in improving steam chamber conformance, reducing incidences of steam breakthrough, high vapour production, and in addressing liner reliability concerns related to steam jetting. While the application of FCDs is well-established in the conventional oil and gas industry to control gas and water coning, there are still a number of questions on how to implement FCDs optimally in SAGD. One major difference in the application of FCDs in SAGD compared to the conventional oil and gas industry is the high temperature environment with steam and elevated erosion risk. The purpose of this paper is to present some practical considerations for the selection of FCDs and optimal completion FCD design for SAGD applications. In the first section, a discussion is presented on how to compare the performance of different flow control devices. Most devices have not been tested for SAGD, and there is a need for more comprehensive testing. The focus of the second section is on practical considerations for the installation of FCDs in a SAGD injection and production wells.
Inhibition of Oncogenic Epidermal Growth Factor Receptor Kinase Triggers Release of Exosome-like Extracellular Vesicles and Impacts Their Phosphoprotein and DNA Content (2015)

Cancer cells emit extracellular vesicles (EVs) containing unique molecular signatures. Here, we report that the oncogenic EGF receptor (EGFR) and its inhibitors reprogram phosphoproteomes and cargo of tumor cell-derived EVs. Thus, phosphorylated EGFR (P-EGFR) and several other receptor tyrosine kinases can be detected in EVs purified from plasma of tumor-bearing mice and from conditioned media of cultured cancer cells. Treatment of EGFR-driven tumor cells with second generation EGFR kinase inhibitors (EKIs), including CI-1033 and PF-00299804 but not with anti-EGFR antibody (Cetuximab) or etoposide, triggers a burst in emission of exosome-like EVs containing EGFR, P-EGFR, and genomic DNA (exo-gDNA). The EV release can be attenuated by treatment with inhibitors of exosome biogenesis (GW4869) and caspase pathways (ZVAD). The content of P-EGFR isoforms (Tyr-845, Tyr-1068, and Tyr-1173), ERK, and AKT varies between cells and their corresponding EVs and as a function of EKI treatment. Immunocapture experiments reveal the presence of EGFR and exo-gDNA within the same EV population following EKI treatment. These findings suggest that targeted agents may induce cancer cells to change the EV emission profiles reflective of drug-related therapeutic stress. We suggest that EV-based assays may serve as companion diagnostics for targeted anticancer agents.
Optimized control strategy enabling minimized capacitance in Modular High Frequency converters (2014)

The Modular High Frequency converter (MHF) is a new converter topology especially designed for vehicle applications. It enables ultra-light weight and volume by drastic reduction of passive components and cooling equipment. This paper deals with an optimized control strategy of the MHF that leads to minimized capacitance installed in the drive system.
ChemInform Abstract: STEREOSPECIFIC SYNTHESIS OF α,β‐DEHYDROAMINO ACIDS FROM β‐HYDROXY α‐AMINO ACID DERIVATIVES (1983)

Abstract Die Hydroxy‐aminosäurederivate (I) werden durch Behandeln mit Diethylamino‐schwefeltrifluorid in die Dehydro‐aminosäuren (II) übergeführt.
Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases (2018)

Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases.
Induction of a putative laminin-binding protein of Streptococcus gordonii in human infective endocarditis (1992)

There is evidence to suggest that the virulence of Streptococcus strains in infective endocarditis might be due to the expression of binding sites for the extracellular matrix proteins of damaged valves. In this communication, we draw attention to one laminin-binding protein from a strain of Streptococcus gordonii isolated from a patient with human endocarditis. This 145-kDa protein was found on the cell wall of the bacterium. The level of expression of this binding protein might be regulated by the presence of extracellular matrix proteins: the protein was lacking after in vitro selection of laminin, collagen I, and fibronectin nonbinding variants, and it was recovered after growth of the variants when laminin or collagen I was added to the growth medium. It was also missing after 10 subcultures in minimal medium, indicating some positive control. Furthermore, the 145-kDa protein was recognized as a major antigen by sera from patients treated for streptococcal infective endocarditis, while sera from patients with valvulopathies gave only slight recognition, suggesting an increase of the expression of this protein during infective endocarditis. It was also shown that the 145-kDa protein carried a collagen I-like determinant detected with anti-human collagen I antibodies.
α‐Synuclein and Polyunsaturated Fatty Acids Promote Clathrin‐Mediated Endocytosis and Synaptic Vesicle Recycling (2008)

Alpha-synuclein (alphaS) is an abundant neuronal cytoplasmic protein implicated in Parkinson's disease (PD), but its physiological function remains unknown. Consistent with its having structural motifs shared with class A1 apolipoproteins, alphaS can reversibly associate with membranes and help regulate membrane fatty acid composition. We previously observed that variations in alphaS expression level in dopaminergic cultured cells or brains are associated with changes in polyunsaturated fatty acid (PUFA) levels and altered membrane fluidity. We now report that alphaS acts with PUFAs to enhance the internalization of the membrane-binding dye, FM 1-43. Specifically, alphaS expression coupled with exposure to physiological levels of certain PUFAs enhanced clathrin-mediated endocytosis in neuronal and non-neuronal cultured cells. Moreover, alphaS expression and PUFA-enhanced basal and -evoked synaptic vesicle (SV) endocytosis in primary hippocampal cultures of wild type (wt) and genetically depleted alphaS mouse brains. We suggest that alphaS and PUFAs normally function in endocytic mechanisms and are specifically involved in SV recycling upon neuronal stimulation.
CFD Simulations of the TP400 IPC With Enhanced Casing Treatment in Off-Design Operating Conditions (2009)

The TP400 intermediate pressure compressor (see Figure 1) is characterized by its extremely wide aerodynamic operating range with strong requirements concerning efficiency and surge margin. Both goals could have been achieved by the proper introduction of variable stator vanes. However, the resulting weight penalty due to the necessary control and actuator system is not accepted — thus this conventional design is rejected and a sophisticated Casing Treatment developed by MTU is introduced. While the underlying multipoint design process is in general expensive and complex the chosen Casing Treatment design (enhanced axial skewed slots [17]) requires the introduction of time accurate 3D CFD simulations in the standard design chain. This ambitious goal leads to the demand for enhanced 3D aerodynamic design tool capabilities like accurate flow prediction in fully turbulent and transitional flow regimes due to different operating conditions as well as the resolution of different geometry features outside the main flow path. In the present paper the effect of different numerical resolution of the “real” geometry as well as the “real” behavior of the flow e.g. steady simulation versus time accurate simulations is discussed. The differences are analyzed and compared to rig-measurements.
Incidence and Timing of Thrombosis After the Norwood Procedure in the Single‐Ventricle Reconstruction Trial (2020)

Background Thrombosis is common in infants undergoing staged surgeries for single-ventricle congenital heart disease. The reported incidence and timing of thrombosis varies widely, making it difficult to understand the burden of thrombosis and develop approaches for prevention. We aimed to determine the timing and cumulative incidence of thrombosis following the stage I Norwood procedure and identify clinical characteristics associated with thrombosis. Methods and Results We analyzed data from the Pediatric Heart Network Single Ventricle Reconstruction trial from 2005 to 2009 and identified infants with first-time thrombotic events. In 549 infants, the cumulative incidence of thrombosis was 21.2% (n=57) from stage I through stage II. Most events occurred during stage I (n=35/57, 65%), with a median time to thrombosis of 15 days. We used a Cox proportional hazards model to estimate the association of clinical variables with thrombosis. After adjusting for baseline variables, boys had a higher hazard of thrombosis (adjusted hazard ratio [HR], 2.69; 95% CI, 1.44-5.05; <i>P</i>=0.002), non-hypoplastic left heart syndrome cardiac anatomy was associated with a higher early hazard of thrombosis (adjusted HR, 3.93; 95% CI, 1.89-8.17; <i>P</i><0.001), and longer cardiopulmonary bypass time was also associated with thrombosis (per 10-minute increase, adjusted HR, 1.07; 95% CI, 1.01-1.12; <i>P</i>=0.02). Lower oxygen saturation after the Norwood procedure increased the hazard for thrombosis in the unadjusted model (HR, 1.08; 95% CI, 1.02-1.14; <i>P</i>=0.011). Conclusions Thrombosis affects 1 in 5 infants through Stage II discharge, with most events occurring during stage I. Male sex, non-hypoplastic left heart syndrome anatomy, longer cardiopulmonary bypass time, and lower stage I oxygen saturation were associated with thrombosis.
Modulation of the Sensitive Temperature Range of Fluorescent Molecular Thermometers Based on Thermoresponsive Polymers (2004)

Fluorescent molecular thermometers based on polymers showing a temperature-induced phase transition and labeled with polarity-sensitive fluorescent benzofurazans are the most sensitive known. Here we show a simple and effective method for modulating the sensitive temperature ranges of fluorescent molecular thermometers based on such temperature-responsive polymers. 4-N-(2-acryloyloxyethyl)-N-methylamino-7-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole was adopted as a polarity-sensitive fluorescent benzofurazan, and nine copolymers of two kinds of acrylamide derivative (N-n-propylacrylamide, N-isopropylacrylamide, and/or N-isopropylmethacrylamide) with a small amount of DBD-AE were obtained. The fluorescence intensities of these copolymers in aqueous solution sharply increased with increasing temperature over a small range (6-7 degrees C). In contrast, these fluorescent molecular thermometers differed from one another in the sensitive temperature range (between 20 and 49 degrees C). Moreover, the sensitive temperature ranges were well related to the acrylamide ratios in feed. In addition, the responses from these fluorescent molecular thermometers to the change in temperature were reversible and exactly repeatable during 10 cycles of heating and cooling (relative standard deviation of the fluorescence intensity, 0.44-1.0%).
Bacterial sialoglycosidases in Virulence and Pathogenesis (2019)

Human oral microbiome and dysbiotic infections have been recently evidently identified. One of the major reasons for such dysbiosis is impairment of the immune system. Periodontitis is a chronic inflammatory disease affecting the tissues that surround and support the teeth. In the United States., approximately 65 million people are affected by this condition. Its occurrence is also associated with many important systemic diseases such as cardiovascular disease, rheumatoid arthritis, and Alzheimer's disease. Among the most important etiologies of periodontitis is <i>Porphyromonas gingivalis,</i> a keystone bacterial pathogen. Keystone pathogens can orchestrate inflammatory disease by remodeling a normally benign microbiota causing imbalance between normal and pathogenic microbiota (dysbiosis). The important characteristics of <i>P. gingivalis</i> causing dysbiosis are its virulence factors which cause effective subversion of host defenses to its advantage allowing other pathogens to grow. Some of the mechanisms involved in these processes are still not well-understood. However, various microbial strategies target host sialoglycoproteins for immune dysregulation. In addition, the enzymes that break down sialoglycoproteins and sialoglycans are the "sialoglycoproteases", resulting in exposed terminal sialic acid. This process could lead to pathogen-toll like receptor (TLR) interactions mediated through sialic acid receptor ligand mechanisms. Assessing the function of <i>P. gingivalis</i> sialoglycoproteases, could pave the way to designing carbohydrate analogues and sialic acid mimetics to serve as drug targets.
Selecting the Implant Height in Breast Augmentation with Anatomical Prosthesis (2013)

Therapeutic, IV.
Effects of β-Carotin and Green Tea Powder Diets on Alleviating the Symptoms of Gouty Arthritis and Improving Gut Microbiota in C57BL/6 Mice (2022)

As a chronic metabolic disease caused by disorders of purine metabolism, gout has shown increasing incidence rate worldwide. Considering that gout is not easily treated and cured, further studies are explored to prevent gout development through diet modification. Both β-carotin and green tea powder are rich in dietary fiber, which helps maintain the balance of gut microbiota in humans. The aim of this study was to investigate the effects of β-carotin and green tea powder diet on the prevention of gouty arthritis in relation to the bacterial structure of gut microbiota in mice. We successfully induced gouty arthritis in C57BL/6 mice by injecting monosodium urate (MSU) crystals and feeding high-fat diet (HFD), and further investigated the effects of additional β-carotin and green tea powder in the diets of mice on the prevention of gouty arthritis in mice. Our results showed that diet of β-carotin and green tea powder reduced the joint swelling and pain in mice with gout, reduced the levels of serum uric acid (UA) and three types of pro-inflammatory cytokines, i.e., interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), improved the gut microbiota profile, and reduced the metabolic levels of purines and pyrimidines. In conclusion, our study provided evidence to support the application of β-carotin and green tea powder diet as a dietary adjustment method to prevent and treat gouty arthritis.
The Inhibition and Promotion of Cancers by Folic Acid, Vitamin B<sub>12</sub>, and Their Antagonists (1985)

For the past two years, our group has been collaborating with that of Dr. Ludwik Gross in the area of these studies, attempting to "switch off" the oncogene for guinea pig leukemia/lymphoma (1). The concept involved is that DNA methylation, and specifically methylation of cytosine in higher eukaryotes can directly suppress gene expression. This concept has been elaborated in several reviews, of which the most recent is by Eick et al. (2) in Analytical Biochemistry 135:165-171, 1983. The first dramatic presentation of possible clinical value of being able to demethylate a gene was the study by Heller and his associates in Chicago suggesting that they could "switch on" the fetal hemoglobin gene using 5-azacytidine, presumably by hypomethylating the fetal globin gene. They collaborated with Ley et al. in a study strongly suggesting that they could, in fact, switch on fetal hemoglobin synthesis with 5-azacytidine (3). This was confirmed by Charache
Gamma Interferon Secretion by Human Vγ2Vδ2 T Cells after Stimulation with Antibody against the T-Cell Receptor plus the Toll-Like Receptor 2 Agonist Pam<sub>3</sub>Cys (2006)

Circulating Vgamma2Vdelta2 T-cell populations in healthy human beings are poised for rapid responses to bacterial or viral pathogens. We asked whether Vgamma2Vdelta2 T cells use the Toll-like receptor (TLR) family to recognize pathogen-associated molecular pattern molecules and to regulate cell functions. Analysis of expanded Vgamma2Vdelta2 T-cell lines showed the abundant presence of TLR2 mRNA, implying that these receptors are important for cell differentiation or function. However, multiple efforts to detect TLR2 protein on the cell surface or in cytoplasmic compartments gave inconsistent results. Functional assays confirmed that human Vgamma2Vdelta2 T cells could respond to the TLR2 agonist (S)-(2,3-bis(palmitoyloxy)-(2RS)-propyl)-N-palmitoyl-(R)-Cys-(S)-Ser(S)-Lys4-OH trihydrochloride (Pam3Cys), but the response required coincident stimulation through the gammadelta T-cell receptor (TCR). Dually stimulated cells produced higher levels of cytoplasmic or cell-free gamma interferon and showed increased expression of the lysosome-associated membrane protein CD107a on the cell surface. A functional TLR2 that requires coincident TCR stimulation may increase the initial potency of Vgamma2Vdelta2 T-cell responses at the site of infection and promote the rapid development of subsequent acquired antipathogen immunity.
Resource Allocation for Ultra-Reliable and Enhanced Mobile Broadband IoT Applications in Fog Network (2018)

In recent years, in order to provide a better quality of service (QoS) to Internet of Things (IoT) devices, the cloud computing paradigm has shifted toward the edge. However, the resource capacity (e.g., bandwidth) in fog network technology is limited and it is essential to efficiently bind the IoT applications with stringent QoS requirements with the available network infrastructure. In this paper, we formulate a joint user association and resource allocation problem in the downlink of the fog network, considering the evergrowing demand of QoS requirements imposed by the ultra-reliable low latency communications and enhanced mobile broadband services. First, we determine the priority of different QoS requirements of heterogeneous IoT applications at the fog network by enforcing the analytical framework using an analytic hierarchy process (AHP). Using the AHP, we then formulate a two-sided matching game to initiate stable association between the fog network infrastructure (i.e., fog devices) and IoT devices. Subsequently, we consider the externalities in the matching game that occurs due to job delay and solve the network resource allocation problem by applying the “best-fit” resource allocation strategy during matching. The simulation results illustrate the stability of the user association and efficiency of resource allocation with higher utility gain.
Microscopy Society of America (2009)

The 67th Annual Meeting of the Microscopy Society of America, held in conjunction with our co-sponsoring societies, will take place in Richmond, Virginia in late July. Now widely known as Microscopy and Microanalysis , this meeting provides the MSA membership with a useful overview of many diverse activities involving microscopy and microanalysis that are of topical interest. In addition to symposia devoted to a range of contemporary topics in the biological and physical sciences, as well as advances in instrumentation, the meeting program will include a set of “Back to Basics” Tutorials, and continuations of the highly successful In-Meeting Intensive Workshops, and the special “Family Affair”, which provides hands-on activities and demonstrations aimed at children of all ages. MSA Council is concerned to reach out to more people in the wider community who utilize microscopes of many shapes and forms in their daily activities, and these developments are just part of our ongoing educational and outreach efforts in this direction.
Uncontrolled generator operation of interior PM synchronous machines following high-speed inverter shutdown (1999)

Interior permanent magnet (IPM) synchronous machine drives are vulnerable to a special fault mode when gating is suddenly removed from the inverter switches during high-speed operation. The resulting IPM machine operation as a generator in combination with an uncontrolled rectifier must be properly understood and accounted for in the machine design to avoid damage to either the machine or inverter. An approximate closed-form solution is derived in this paper which relates the resulting machine phase current (and torque) to the IPM machine parameters, the DC-link voltage and the rotor speed. The resulting operating characteristics are particularly interesting for IPM machines that have been designed with inductance saliency ratios greater than 2 (i.e., high-saliency machines). The validity of the approximate solution is confirmed using dynamic simulation results, and the implications of these results for the machine designer seeking to minimize or eliminate the impact of this undesired operating mode are thoroughly discussed.
HIGH POWER CAVITY COMBINER FOR RF AMPLIFIERS (2006)

A new approach of RF power combination has been developed for the ALBA Storage Ring RF system: a three port high power Cavity Combiner (CaCo). A prototype has been successfully built and tested in Thales Electron Devices, Thonon, France. The final goal is to combine the power of two 80 kW IOTs at 500 MHz, in order to provide a total output power of more than 150 kW. In this paper, a summary of the analytical and simulation analysis of the expected behaviour is given. In basis of that, the decided geometric constrains and the final design configuration chosen for the prototype production are explained. Low power test results and matching, and finally the high power test performances are shown. As a conclusion, the RF system of the ALBA Storage Ring will incorporate the CaCo concept to obtain the needed power per cavity from the combination of two IOTs.
Challenge of Design Data Exchange between heterogeneous Database Schema (2004)

The development of complex systems becomes increasingly difficult. The diversity and number of tools necessary to develop such a system is extensive. One solution to exchange engineering data between these tools is the Standard for Product Data Exchange (STEP), ISO 10303. It offers domain specific database schema called application protocols. This paper analyses the problems of the data exchange between tools via an application protocol. and proposes a Transformation Report, which records individual transformation steps during the exchange between two different tools. The Transformation Report supports the understanding of the data exchange process and helps correcting incomplete or incorrect transformed data.
Generalized Venn diagrams: a new method of visualizing complex genetic set relations (2004)

hans.kestler@medizin.uni-ulm.de.
Acid/Base‐ and Anion‐Controllable Organogels Formed From a Urea‐Based Molecular Switch (2010)

A switch in time: Gel–sol transitions of a urea-based [2]rotaxane gelator are controlled by the degree of solvent exposure of the hydrogen-bond-donating urea station and the orientation of the hydrogen-bond-accepting CO groups of the interlocked ethylene glycol based macrocycle (N blue, O and macrocycle red, phenyl green). Both acid/base and anion-exchange control can be used to reversibly transition the rotaxane in 1-pentanol between solution and gel states.
Compression-Arthrodesis of Finger Joints using Kirschner Wires and Cerclage (1982)

A retrospective series of forty-three finger joint arthrodesis is presented. The failure rate was seven per cent. A new method of introducing a cerclage wire into bone is demonstrated. Septic arthritis of finger joints is considered to be an indication for acute arthrodesis.