gebhart/patrepeval huggingface dataset:
Enhancing Game-Server AI with Distributed Client Computation (2007)

In the context of online role-playing games, we evaluate offloading AI computation from game servers to game clients. In this way, the aggregate resources of thousands of participating client machines can enhance game realism in a way that would be prohibitively expensive on a central server. Because offloading can add significant latency to a computation normally executing within a game server’s main loop, we introduce the mechanism of AI partitioning: splitting an AI into a high-frequency but computationally simple component on the server, and a lowfrequency but computationally intensive component offloaded to a client. By designing the client-side component to be stateless and deterministic, this approach also facilitates rapid handoff, preemptive migration, and replication, which can address the problems of client failure and exploitation. To explore this approach, we develop an improved AI for tactical navigation, a challenging task to offload because it is highly sensitive to latency. Our improvement is based on calculating influence fields, partitioned into server-side and client-side components by means of a Taylor series approximation. Experiments on a Quake-based prototype demonstrate that this approach can substantially improve the AI’s abilities, even with server-clientserver latencies up to one second.
Experimental evidence of S1 mode quasi-resonance in thin plates using a laser based acoustic microscope (2006)

An amplitude modulated continuous wave laser source is used to generate Lamb waves in thin plates. The source is a 1550nm electro-absorption modulated laser. The acoustic waves are detected with a Michelson interferometer operating at 532nm. This system provides narrow-bandwidth detection at frequencies up to 200 MHz with extremely high sensitivity. The dispersion curves of up to five Lamb modes were constructed for 50µm tungsten plate, and we demonstrate that the laser source couples very efficiently into the quasi-resonance at the S1 minimum frequency.
Spatially compressed dual-wavelength excitation Raman spectrometer (2014)

The design and operation of a novel dual-laser excitation Raman instrument is described. The use of two lasers of differing wavelengths allows for a Raman spectrum covering all fundamental modes of vibration to be collected while minimizing fluorescence and allowing for spatial compression of the spectrum on an imaging detector. The use of diode lasers with integrated distributed Bragg reflector gratings facilitates the use of an integrated thermoelectric cooler to allow collection of shifted excitation spectra for both of the lasers, further enhancing the rejection of fluorescence. An example is given, which uses seven excitation wavelengths for each laser to reconstruct the Raman spectrum of a solvent in the presence of a highly fluorescent dye by using a sequentially shifted excitation Raman reconstruction algorithm.
Development of a vaccine against the synthetic opioid U-47700 (2023)

Opioid use disorders and overdose have become a major public health concern in recent years. U-47700, a New psychoactive substances (NPS) opioid, also known as "pinky" or "pink" has been identified as a new threat in the drug supply because of its potency and abuse potential. Conjugate vaccines that can produce antibodies against target drug molecules have emerged as a promising tool to treat substance use disorders. Herein, we report the design, synthesis, and <i>in vivo</i> characterization of a U-47700 vaccine. The vaccine demonstrated favorable results with rodents producing elevated levels of antibody titer and sub-micromolar affinity to U-47700. In addition, antibodies generated by the vaccine effectively mitigated drug-induced effects by preventing the drug from penetrating the blood-brain barrier, which was verified by antinociception and drug biodistribution studies. The development of a vaccine against U-47700 and other NPS opioids contributes to the continued advancement of non-conventional pharmacological treatments to address the global opioid epidemic.
An integrated optoelectronic oscillator (2017)

An integrated optoelectronic Oscillator (IOEO) which combines the integrated technologies of photonics and electronics has been developed. All of the necessary elements (for example, laser, photo-detector, electrical amplifier, electrical filter, etc.) have been assembled on a print circuit board (PCB) within size of 5*6 cm. To the best of our knowledge, it is the first time to integrate both the optical part and electrical part on a single substrate. Finally, a stable microwave signal with the frequency of 7.3 GHz is obtained. The center oscillation frequency can be slightly tuned in 20 MHz bandwidth by strictly tuning the injection current. The phase noise is around - 91dBc/Hz at 1MHz.
A CMOS dual-band fractional-n synthesizer with reference doubler and compensated charge pump (2004)

A fully integrated dual-band frequency synthesizer in 0.35 /spl mu/m CMOS technology achieves a phase noise of -141 dBc/Hz at 1.25 MHz offset in the PCS band with a reference frequency doubler. Fractional spurs are reduced by 8.6 dB at 50 kHz offset with a replica compensated charge pump.
Selection-Based Discovery of Druglike Macrocyclic Peptides (2014)

Macrocyclic peptides are an emerging class of therapeutics that can modulate protein-protein interactions. In contrast to the heavily automated high-throughput screening systems traditionally used for the identification of chemically synthesized small-molecule drugs, peptide-based macrocycles can be synthesized by ribosomal translation and identified using in vitro selection techniques, allowing for extremely rapid (hours to days) screening of compound libraries comprising more than 10(13) different species. Furthermore, chemical modification of translated peptides and engineering of the genetic code have greatly expanded the structural diversity of the available peptide libraries. In this review, we discuss the use of these technologies for the identification of bioactive macrocyclic peptides, emphasizing recent developments.
Ultra-compact visible chiral spectrometer with meta-lenses (2017)

Conventional compact spectrometers have a fixed spectral resolution and cannot resolve the polarization properties of light without additional optical elements, while their larger counterparts are bulky and costly. Here, we demonstrate multiple off-axis meta-lenses in the visible integrated on a single planar substrate. They possess both focusing and strongly dispersive properties and are designed to provide different spectral resolutions as well as working wavelength ranges on the same chip. We realize a compact spectrometer using only these meta-lenses and a CMOS camera and achieve detector-limited spectral resolutions as small as 0.3 nm and a total working wavelength range exceeding 170 nm for a beam propagation length of only a few cm. In addition, this spectrometer has the capability to resolve different helicities of light in a single measurement. This chip-camera setup represents the most compact configuration so far achieved for a spectrometer with similar performance and functionality, and its compatibility with large-scale fabrication processes makes it broadly applicable.
Photonic crystal vertical-cavity lasers (2004)

Photonic crystal confinement in vertical cavity surface-emitting lasers (VCSELs) is a robust and reliable technology for achieving operation in the fundamental lateral mode and is potentially applicable to a variety of materials systems and operating wavelengths. We demonstrate photonic crystal VCSELs operating in a single transverse mode with over 30 dB side mode suppression and over 1 mW of output power. These lasers have been subjected to a post-process technique to introduce the etched holes making up the photonic crystals that surround a centralized defect in which lasing occurs. We also show that coupling between adjacent defects in a photonic lattice is possible, further increasing the power available in the devices.
Eddy current imager for the detection of buried flaws in large metallic structures (2006)

International audience
Altered Telomeres in Tumors with <i>ATRX</i> and <i>DAXX</i> Mutations (2011)

The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres and other genomic sites. Because inactivating mutations of these genes are common in human pancreatic neuroendocrine tumors (PanNETs), we examined the telomere status of these tumors. We found that 61% of PanNETs displayed abnormal telomeres that are characteristic of a telomerase-independent telomere maintenance mechanism termed ALT (alternative lengthening of telomeres). All of the PanNETs exhibiting these abnormal telomeres had ATRX or DAXX mutations or loss of nuclear ATRX or DAXX protein. ATRX mutations also correlate with abnormal telomeres in tumors of the central nervous system. These data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes.
Experimental Analysis of Solar Driven Multi-Stage Stepped Bubbler Humidifier for Humidification-Dehumidification (HDH) Water Desalination System (2016)

The fresh water is the essence of life and its scarcity is the most threatening concern for mankind. To alleviate the worries of the existing and approaching fresh water crisis, the answer for water sustainability may lie in developing the decentralized small-scale water desalination system. Solar humidification-dehumidification (HDH) is a carrier gas based thermal technique that is ideal for a small-scale decentralized water desalination system. An innovative design approach is to use the bubble column humidifier to enhance the performance of the HDH water desalination system. Therefore, a novel multi-stage stepped bubble column humidifier is proposed that is operated through solar thermal energy as the main source of energy input. The study addresses the relation between the pressure drop variations with varying water column height at different air superficial velocities. Findings revealed that the water column height and air superficial velocity should be optimized according to the geometric features of the perforated plate in order to achieve a higher humidifier performance with a lower pressure drop. The day round performance of the humidifier is investigated in single stage, two stage, and three stage configurations. Findings show that the average day round absolute humidity at the exit of the humidifier is increased by 9 % in two-stage and 23 % in three-stage configurations compared to the single stage humidifier. One major advantages of this proposed humidifier is its ability to have a direct solar thermal heating. Subsequently, it can be located in remote areas.
Fiber Bragg grating displacement sensor for movement measurement of tendons and ligaments (2007)

Biomechanical studies often involve measurements of the strains developed in tendons or ligaments in posture or locomotion. Fiber-optic sensors present an attractive option for the measurement of strains in tendons and ligaments because of their low cost, ease of implementation, and increased accuracy compared with other implantable transducers. A new displacement sensor based on a fiber Bragg grating and shape memory alloy technology is proposed for the monitoring of tendon and ligament strains in different postures and in locomotion. After sensor calibration in the laboratory, a comparison of the fiber sensors and traditional camera displacement sensors was carried out to evaluate the performance of the fiber sensor during the application of tension to the Achilles tendon. Additional experiments were performed in cadaver knees to assess the suitability of these fiber sensors to measure ligament deformation in a variety of simulated postures. The results demonstrate that the proposed fiber Bragg grating sensor is a highly accurate, easily implantable, and minimally invasive method of measuring tendon and ligament displacement.
SAW Sensors for Chemical Vapors and Gases (2017)

Surface acoustic wave (SAW) technology provides a sensitive platform for sensing chemicals in gaseous and fluidic states with the inherent advantages of passive and wireless operation. In this review, we provide a general overview on the fundamental aspects and some major advances of Rayleigh wave-based SAW sensors in sensing chemicals in a gaseous phase. In particular, we review the progress in general understanding of the SAW chemical sensing mechanism, optimization of the sensor characteristics, and the development of the sensors operational at different conditions. Based on previous publications, we suggest some appropriate sensing approaches for particular applications and identify new opportunities and needs for additional research in this area moving into the future.
<title>Improved image guidance of coronary stent deployment</title> (2000)

Accurate placement and expansion of coronary stents is hindered by the fact that most stents are only slightly radiopaque, and hence difficult to see in a typical coronary x-rays. We propose a new technique for improved image guidance of multiple coronary stents deployment using layer decomposition of cine x-ray images of stented coronary arteries. Layer decomposition models the cone-beam x-ray projections through the chest as a set of superposed layers moving with translation, rotation, and scaling. Radiopaque markers affixed to the guidewire or delivery balloon provide a trackable feature so that the correct vessel motion can be measured for layer decomposition. In addition to the time- averaged layer image, we also derive a background-subtracted image sequence which removes moving background structures. Layer decomposition of contrast-free vessels can be used to guide placement of multiple stents and to assess uniformity of stent expansion. Layer decomposition of contrast-filled vessels can be used to measure residual stenosis to determine the adequacy of stent expansion. We demonstrate that layer decomposition of a clinical cine x-ray image sequence greatly improves the visibility of a previously deployed stent. We show that layer decomposition of contrast-filled vessels removes background structures and reduces noise.
A Powered Prosthetic Intervention for Bilateral Transfemoral Amputees (2014)

This paper presents the design and validation of a control system for a pair of powered knee and ankle prostheses to be used as a prosthetic intervention for bilateral transfemoral amputees. The control system leverages communication between the prostheses for enhanced awareness and stability, along with power generation at the knee and ankle joints to better restore biomechanical functionality in level ground walking. The control methodology employed is a combination of an impedance-based framework for weight-bearing portions of gait and a trajectory-based approach for the nonweight-bearing portions. The control system was implemented on a pair of self-contained powered knee and ankle prostheses, and the ability of the prostheses and control approach to provide walking functionality was assessed in a set of experimental trials with a bilateral transfemoral amputee subject. Specifically, experimental data from these trials indicate that the powered prostheses and bilateral control architecture provide gait kinematics that reproduce healthy gait kinematics to a greater extent than the subject's daily-use passive prostheses.
Error concealment of H.264/AVC inter-coded video frames (2010)

In this paper, we propose a procedure to recover lost slices in inter-coded H.264/AVC video frames. The procedure recovers missing pixels by exploiting temporal information. In particular, it considers 4 × 4 blocks and performs a full search procedure on an adaptive size window in the reference frames, in order to determine the best block according to a specified metric. One key point of the proposed technique is the use of a modified metric, that takes into account continuity at the block boundaries as well as the smoothness of the motion field. Experimental results show that the proposed scheme compares favorably with existing state-of-the-art methods, both objectively and subjectively.
Influenza A Virus Matrix Protein 1-Specific Human CD8<sup>+</sup>T-Cell Response Induced in Trivalent Inactivated Vaccine Recipients (2008)

Among 17 HLA-A2-positive healthy adults, CD8+ T-cell responses against an HLA-A2-restricted matrix protein 1 (M1) epitope increased after immunization with trivalent inactivated influenza vaccine (TIV) in two individuals. The presence of M1 in TIV was confirmed by Western blotting. T-cell cytotoxicity assays showed that TIV is processed and the epitope is presented by antigen-presenting cells to an M1 epitope-specific CD8+ T-cell line for specific lysis. These data show that TIV, which is formulated to contain surface glycoproteins to induce serotype-specific antibody responses, also contains M1, capable of inducing subtype cross-reactive CD8+ T-cell responses in some vaccinees.
A heme fusion tag for protein affinity purification and quantification (2010)

We report a novel affinity-based purification method for proteins expressed in Escherichia coli that uses the coordination of a heme tag to an L-histidine-immobilized sepharose (HIS) resin. This approach provides an affinity purification tag visible to the eye, facilitating tracking of the protein. We show that azurin and maltose binding protein are readily purified from cell lysate using the heme tag and HIS resin. Mild conditions are used; heme-tagged proteins are bound to the HIS resin in phosphate buffer, pH 7.0, and eluted by adding 200-500 mM imidazole or binding buffer at pH 5 or 8. The HIS resin exhibits a low level of nonspecific binding of untagged cellular proteins for the systems studied here. An additional advantage of the heme tag-HIS method for purification is that the heme tag can be used for protein quantification by using the pyridine hemochrome absorbance method for heme concentration determination.
Multimode random fiber laser for speckle free imaging (2018)

It is the first time that a multi transverse mode random fiber laser with high radiance and low coherence is used for speckle-free imaging, which is ideal for wide field or high-speed imaging applications.
Support for real-time computing within general purpose operating systems-supporting co-resident operating systems (2002)

Distributed multimedia applications are typical of a new class of workstation applications that require real-time communication and computation services to be effective. Unfortunately, there remains a wide gap between the development of real-time computing technology in the research community and the deployment of real-time solutions in commercial systems. We explore technology for allowing two operating systems, a general purpose operating system and a predictable real-time kernel, to co-exist on the same hardware. We discuss the problems of multiplexing shared devices and partitioning shared data structures to accommodate two operating systems, and present a CPU executive that allows the IBM Microkernel (a derivative of the Mach microkernel) with an OSF/1 server to co-exist with a simple real-time kernel we have built. We also extend the traditional theory of scheduling periodic tasks on a uniprocessor to accommodate the case where a real-time kernel is allocated only a fraction of the total CPU capacity.
The pathogenesis of autosomal dominant polycystic kidney disease: an update (2000)

The identification of PKD1 and PKD2, the two major genes responsible for autosomal dominant polycystic kidney disease, are the seminal discoveries upon which much of the current investigation into the pathogenesis of this common heritable disease is based. A major mechanistic insight was achieved with the discovery that autosomal dominant polycystic kidney disease occurs by a two-hit mechanism requiring somatic inactivation of the normal allele in individual polarized epithelial cells. Most recent advances are focused on the function of the respective protein products, polycystin-1 and polycystin-2. Indirect evidence supports an interaction between polycystin-1 and -2, albeit it is unlikely that they work in concert in all tissues and at all times. They associate in yeast two hybrid and cotransfection assays and there is a striking similarity in the renal and pancreatic cystic phenotypes of Pkd2-/- and Pkd1del34/del34 mice. Also, the respective homologues of both proteins are expressed in the same sensory neuronal cells in the nematode and the human disease phenotypes remain completely overlapping with the major difference being in relative severity. Mounting evidence supports the hypothesis that polycystin-1 is a cell surface receptor. A close homologue in the sea urchin sperm mediates the acrosome reaction in response to contact with egg-jelly, the nematode homologue functions in mechano- or chemosensation, and the solution structure of the repeated extracellular polycystic kidney disease domains reveals a beta-sandwich fold commonly found in surface receptor molecules. Indirect evidence also supports the initial hypothesis that polycystin-2 is a calcium channel subunit. Several closely related homologues retain the calcium channel signature motif but differ in their predicted interaction domains, and one of these homologues has been shown to be a calcium regulated cation channel. Several important distinctions in polcystin-1 and -2 function have also been discovered. Polycystin-2 has a role in cardiac development that polcystin-1 does not. High level polycystin-2 expression in renal epithelial cells coincides with maturation and elongation of tubules and, unlike polycystin-1, persists into adulthood. In cells in tissue culture, polycystin-2 is expressed exclusively in the endoplasmic reticulum whilst the cellular expression of polycystin-1 remains unknown. Overall, the difficult task of understanding the autosomal dominant polycystic disease process is proceeding apace.
WORLDWIDE USE OF HERMETIC STORAGE FOR THE PRESERVATION OF AGRICULTURAL PRODUCTS (2012)

This paper discusses various forms of hermetic storage and transport, which preserve dried commodities such as grains (rice, maize, beans, wheat), silage, coffee, cocoa and seeds. Discussed are its limitations, and the expanding needs of 5 continents and 90 countries that use hermetic storage. Hermetic storage has proven especially effective in hot, humid climates to combat frequent, devastating post harvest losses and prevent the growth of mold related aflatoxins, a major public health hazard. With hermetic storage systems, post harvest losses are reduced to < 1% in hot, humid climates; this is in marked contrast to conventional storage systems requiring pesticides or refrigeration, which often reach 25% losses or more. Scientific information based on insect and commodity respiration, as well as the use of injected CO2 (in some cases) to more rapidly decrease oxygen levels, is now a superior alternative to refrigeration for multi-month seed preservation. Finally, the paper addresses the cost effectiveness of hermetic storage versus alternative storage systems.