gebhart/patrepeval huggingface dataset:
A laser-programmable multichip module on silicon (2002)

A laser-programmable substrate for multichip modules comprises a silicon substrate with a dense, predefined array of pads, tracks and links. A pattern of wiring connecting some of the pads is formed with a laser. Integrated circuit chips are mounted on the substrate, and the chip pads are wire-bonded to the substrate pads. East-west tracks are on the second level of metal, and north-south tracks on the first level. Power, ground, and signals share the tracks on the two metal layers. There is an array of 258-by-258 pads on a 200- mu m pitch, and there are three signal tracks, one power track, and one ground track between any two adjacent pads. Links consist of a silicon nitride layer sandwiched between the two metal layers. When a laser pulse of the correct power and duration is directed to the link region, the metal and nitride fuse to form a conductive vertical path, with a resistance typically two ohms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Feasibility of Shallow Time Domain Reflectometry Probes to Describe Solute Transport Through Undisturbed Soil Cores (2002)

Rapid and nondestructive methods for determining solute transport properties are useful in many soil science applications. Recently, a series of field methods and a time domain reflectometry (TDR) method that could estimate some of the mobile‐immobile model (MIM) parameters, immobile water content (θ im ) and mass exchange coefficient (α), have been reported. The first objective of this study was to determine an additional parameter, dispersion coefficient ( D m ), using the TDR method. The three MIM parameters were estimated from the TDR‐measured data, and the estimated parameters were compared with the estimated parameters from the effluent data. The second objective was to determine whether the TDR‐determined parameters from the surface 2‐cm soil layer could be used to predict effluent breakthrough curves (BTC) at the 20‐cm depth. The TDR‐determined parameters were used to calculate effluent BTCs using the CXTFIT computer program. Parameters obtained by curve fitting of the three parameters simultaneously using TDR data were not similar to the parameters obtained from the effluent BTCs. The parameter estimations were improved by fixing one or two independently determined parameter(s) before curve fitting for the remaining unknown parameter(s). The calculated BTCs were similar to the observed BTCs with coefficient of determination ( r 2 ) being 0.99 and root mean square error (RMSE) being 0.036. The TDR data obtained from shallow soil layers were successfully used to describe solute transport through undisturbed soil cores.
Dynamics of star-burst dendrimers in solution in relation to their structural properties (2002)

We have measured both the static and dynamic structure factors of a single dendrimer with small-angle x-ray scattering (SAXS) and neutron spin-echo spectroscopy under good solvent conditions with the aim of finding a consistent correlation between the structural properties of dendrimers and their dynamic behavior. The samples under investigation were star-burst polyamidoamine dendrimers with generations g=0 to 8 in dilute methanol solutions. A model independent approach employing inverse Fourier transformation and square root deconvolution methods has been used to analyze the SAXS data to obtain the pair distance distribution function p(r) and the radial excess electron density profile Δρ(r). In addition, we formulated a model that takes both the colloidal (globular, compact shape with form polydispersity or fuzzy surface) as well as the loose, polymeric (self-avoiding random walk) character of dendrimers into account. With this model we were able to describe the spectra of all dendrimer generations consistently. Parameters discussed as a function of the dendrimer generation are, among others, the correlation length of the density fluctuations (blob radius) ξ, the radius of gyration Rg, the sphere radius Rs, the form polydispersity σs or analogously, the width of the fuzzy surface region 2σf. Both the model-independent approach and the model fits reveal that at least down to the third generation the dendrimers exhibit a rather compact, globular shape. These findings are in agreement with the dynamic results obtained by NSE spectroscopy which probes length scales both larger and much smaller than the dimension of a single dendrimer. The method reveals that the dynamics throughout is dominated by the center-of-mass diffusion—the internal dynamics is suppressed. The diffusion coefficients obtained are close to the values calculated from the Stokes–Einstein relation using the sphere radius Rs determined from the SAXS spectra. Dynamically, the dendrimers behave like “hard”, solid spheres.
Proteoglycan and collagen synthesis are correlated with actin organization in dedifferentiating chondrocytes. (1991)

The dedifferentiation of chondrocytes in culture is classically associated with a transition from a rounded to a spread morphology. However, the loss of chondroitin sulfate proteoglycan (CSPG) and type II collagen gene expression (markers of the differentiated chondrocyte) does not occur for all polygonal or fibroblast-like cells at the same stage of culture. Furthermore, it has been demonstrated that retinoic acid-dedifferentiated chondrocytes can reexpress type II collagen if treated by the microfilament disruptive drug dihydrocytochalasin B, without a return to the spherical shape. In the present study, we have investigated by fluorescent double-staining whether the synthesis of both CSPG and type II collagen by dedifferentiating chick chondrocytes in low density cultures is dependent on a type of actin organization. We report that the synthesis of CSPG and type II collagen synthesis is coincident with the presence of a faint microfibrillar actin architecture but is absent in chondrocytes showing well defined actin cables. This correlation was observed independently of the shapes exhibited by the cells. Moreover, type I collagen (marker of the dedifferentiated chondrocyte) is synthesized mainly in cells showing large actin cables. This study, performed in the absence of drugs, suggests that actin organization, rather than changes in cell shape, is involved in modulating the chondrogenic phenotype in vitro.
N1,N5,N10-Tris(4-hydroxycinnamoyl)spermidines fromMicrodesmis keayana Roots (2006)

Three new N1,N5,N10-tris(4-hydroxycinnamoyl)spermidines were isolated from a methanolic root extract of Microdesmis keayana. They were identified as N5,N10-di(p-coumaroyl)-N1-feruloylspermidine,N5-(p-coumaroyl)-N1,N10-diferuloylspermidine, and N1,N5,N10-triferuloylspermidine, and were named keayanidines A, B, and C (1-3), respectively. Their structures were established by spectral techniques(electrospray mass spectrometry, one- and two-dimensional NMR). A 4',4'',4'''-trimethylated derivative was prepared by methylation of keayanidine C, and the same compound was synthesized fromspermidine and 3,4-dimethoxycinnamic acid to confirm the spectral attributions of the NMR data of the natural compounds. Radical-scavenging properties of all compounds were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical spectrophotometric assay.
Heavy minerals as a guide to turbidite provenance in the Lower Palaeozoic Southern Welsh Basin: a pilot study (1992)

Abstract A pilot study has demonstrated that heavy mineral analysis is a useful guide to the provenance of Silurian turbidites in the Southern Welsh Basin. The results confirm the sedimentological evidence for two distinct source areas of coarse clastic detritus, one lying to the south and the other to the east. They also provide mineralogical criteria by which the two source areas may be distinguished. The southern area provided material with relatively low mineral diversity, and is characteristic in having low rutile/zircon ratios, whereas the eastern source provided more diverse assemblages, generally with high rutile/zircon ratios. The southern source shows variations in terms of apatite/tourmaline ratio, with the older Aberystwyth Grits Group tending to contain relatively low apatite compared with the younger Cwmystwyth Grits Group (Rhuddnant and Pysgotwr Grits formations). There is evidence for polycyclic material and volcanic detritus in both southerly and easterly derived samples; however, easterly-sourced sandstones apparently tapped a more lithologically-diverse terrain.
Big Health Application System based on Health Internet of Things and Big Data (2016)

The world is facing problems, such as uneven distribution of medical resources, the growing chronic diseases, and the increasing medical expenses. Blending the latest information technology into the healthcare system will greatly mitigate the problems. This paper presents the big health application system based on the health Internet of Things and big data. The system architecture, key technologies, and typical applications of big health system are introduced in detail.
The Circadian System in Higher Plants (2009)

The circadian clock regulates diverse aspects of plant growth and development and promotes plant fitness. Molecular identification of clock components, primarily in Arabidopsis, has led to recent rapid progress in our understanding of the clock mechanism in higher plants. Using mathematical modeling and experimental approaches, workers in the field have developed a model of the clock that incorporates both transcriptional and posttranscriptional regulation of clock genes. This cell-autonomous clock, or oscillator, generates rhythmic outputs that can be monitored at the cellular and whole-organism level. The clock not only confers daily rhythms in growth and metabolism, but also interacts with signaling pathways involved in plant responses to the environment. Future work will lead to a better understanding of how the clock and other signaling networks are integrated to provide plants with an adaptive advantage.
IWSHM 2017: Application of guided wave methods to quantitatively assess healing in osseointegrated prostheses (2018)

Osseointegrated prosthesis is essentially a prosthetic fixture surgically implanted into the bone that extends out of the limb so that an artificial limb can be attached. While osseointegrated prostheses can dramatically improve the quality of life of amputees, there remains a lack of quantitative evidence of the osseointegration process that occurs at the bone–prosthesis surface after surgery. This study advances a sensing strategy that employs piezoelectric elements mounted to the percutaneous end of the prosthesis to generate guided waves that propagate along the length of the prosthesis fixture. The properties of the guided waves exhibit sensitivity to both the degree of bone healing that occurs at the prosthesis surface and the movement of the prosthesis due to loss of osseointegration. Use of the prosthesis as a wave guide offers care providers a quantitative approach to determining when an osseointegrated prosthesis can be loaded and tracks the integrity of osseointegration over the lifespan of the amputee. The study validates the proposed guided wave strategy using a prosthesis model consisting of a solid titanium rod implanted in an adult femoral bone. First, a high-fidelity finite element model is created to study changes in guided waves as a result of bone healing. A laboratory model is also adopted using a synthetic femoral bone identical to that modeled in the finite element model. The energy of the first longitudinal wave mode introduced at the percutaneous end of the prosthesis provides a repeatable metric for accurate assessment of both osseointegration and prosthesis pullout from the bone. The results of this study reveal that the energy of the longitudinal wave mode decreases by nearly half during the osseointegration healing process. In addition, the wave energy is also found to increase as the osseointegrated fixture loosens and is withdrawn from the bone.
Combinatorial TGF-β attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells (2015)

Distant relapse after chemotherapy is an important clinical issue for treating breast cancer patients and results from the development of cancer stem-like cells (CSCs) during chemotherapy. Here we report that blocking epithelial-to-mesenchymal transition (EMT) suppresses paclitaxel-induced CSCs properties by using a MDA-MB-231-xenografted mice model (in vivo), and breast cancer cell lines (in vitro). Paclitaxel, one of the cytotoxic taxane-drugs such as docetaxel, increases mesenchymal markers (Vimentin and Fibronectin) and decreases an epithelial marker (Zo-1). Blocking TGF-β signaling with the TGF-β type I receptor kinase (ALK5) inhibitor, EW-7197, suppresses paclitaxel-induced EMT and CSC properties such as mammosphere-forming efficiency (MSFE), aldehyde dehydrogenase (ALDH) activity, CD44+/CD24- ratio, and pluripotency regulators (Oct4, Nanog, Klf4, Myc, and Sox2). The combinatorial treatment of EW-7197 improves the therapeutic effect of paclitaxel by decreasing the lung metastasis and increasing the survival time in vivo. We confirmed that Snail is increased by paclitaxel-induced intracellular reactive oxygen species (ROS) and EW-7197 suppresses the paclitaxel-induced Snail and EMT by attenuating paclitaxel-induced intracellular ROS. Knock-down of SNAI1 suppresses paclitaxel-induced EMT and CSC properties. These data together suggest that blocking the Snail-induced EMT with the ALK5 inhibitor attenuates metastasis after paclitaxel-therapy and that this combinatorial approach could prove useful in treating breast cancer.
Haploinsufficiency of the <i>Pten</i> tumor suppressor gene promotes prostate cancer progression (2001)

The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of heterozygosity are observed at the 10q23.3 region containing the human PTEN gene in prostate cancer and other human malignancies, but the demonstrated rate of biallelic inactivation of the PTEN gene by mutation or homozygous deletion is significantly lower than the rate of loss of heterozygosity. The transgenic adenocarcinoma of mouse prostate model is a well characterized animal model of prostate cancer. Analysis of prostate cancer progression in transgenic adenocarcinoma of mouse prostate mice bred to Pten(+/-) heterozygous mice, coupled with analysis of the Pten gene and protein in the resulting tumors, reveals that haploinsufficiency of the Pten gene promotes the progression of prostate cancer in this model system. This observation provides a potential explanation for the discordance in rates of loss of heterozygosity at 10q23 and biallelic PTEN inactivation observed in prostate cancer and many human malignancies.
Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia (2008)

Loss-of-function mutations in progranulin (GRN) cause ubiquitin- and TAR DNA-binding protein 43 (TDP-43)-positive frontotemporal dementia (FTLD-U), a progressive neurodegenerative disease affecting approximately 10% of early-onset dementia patients. Here we expand the role of GRN in FTLD-U and demonstrate that a common genetic variant (rs5848), located in the 3'-untranslated region (UTR) of GRN in a binding-site for miR-659, is a major susceptibility factor for FTLD-U. In a series of pathologically confirmed FTLD-U patients without GRN mutations, we show that carriers homozygous for the T-allele of rs5848 have a 3.2-fold increased risk to develop FTLD-U compared with homozygous C-allele carriers (95% CI: 1.50-6.73). We further demonstrate that miR-659 can regulate GRN expression in vitro, with miR-659 binding more efficiently to the high risk T-allele of rs5848 resulting in augmented translational inhibition of GRN. A significant reduction in GRN protein was observed in homozygous T-allele carriers in vivo, through biochemical and immunohistochemical methods, mimicking the effect of heterozygous loss-of-function GRN mutations. In support of these findings, the neuropathology of homozygous rs5848 T-allele carriers frequently resembled the pathological FTLD-U subtype of GRN mutation carriers. We suggest that the expression of GRN is regulated by miRNAs and that common genetic variability in a miRNA binding-site can significantly increase the risk for FTLD-U. Translational regulation by miRNAs may represent a common mechanism underlying complex neurodegenerative disorders.
Incorporated Fish Oil Fatty Acids Prevent Action Potential Shortening Induced by Circulating Fish Oil Fatty Acids (2010)

Increased consumption of fatty fish, rich in omega-3-polyunsaturated fatty acids (ω3-PUFAs) reduces the severity and number of arrhythmias. Long-term ω3-PUFA-intake modulates the activity of several cardiac ion channels leading to cardiac action potential shortening. Circulating ω3-PUFAs in the bloodstream and incorporated ω3-PUFAs in the cardiac membrane have a different mechanism to shorten the action potential. It is, however, unknown whether circulating ω3-PUFAs in the bloodstream enhance or diminish the effects of incorporated ω3-PUFAs. In the present study, we address this issue. Rabbits were fed a diet rich in fish oil (ω3) or sunflower oil (ω9, as control) for 3 weeks. Ventricular myocytes were isolated by enzymatic dissociation and action potentials were measured using the perforated patch-clamp technique in the absence and presence of acutely administered ω3-PUFAs. Plasma of ω3 fed rabbits contained more free eicosapentaenoic acid (EPA) and isolated myocytes of ω3 fed rabbits contained higher amounts of both EPA and docosahexaenoic acid (DHA) in their sarcolemma compared to control. In the absence of acutely administered fatty acids, ω3 myocytes had a shorter action potential with a more negative plateau than ω9 myocytes. In the ω9 myocytes, but not in the ω3 myocytes, acute administration of a mixture of EPA + DHA shortened the action potential significantly. From these data we conclude that incorporated ω3-PUFAs into the sarcolemma and acutely administered ω3 fatty acids do not have a cumulative effect on action potential duration and morphology. As a consequence, patients with a high cardiac ω3-PUFA status will probably not benefit from short term ω3 supplementation as an antiarrhythmic therapy.
Effect of preventive or therapeutic treatment with angiotensin 1–7 in a model of bleomycin-induced lung fibrosis in mice (2019)

Idiopathic pulmonary fibrosis is characterized by aberrant fibroblast activation and excessive collagen deposition that may eventually lead to organ dysfunction. Lung fibrosis is frequently observed in cancer patients undergoing bleomycin (BLM) treatment. Therefore, BLM instillation in mice is the most frequent model used to investigate pulmonary fibrosis. Angiotensin 1-7 [Ang-(1-7)] is a heptapeptide with anti-inflammatory and proresolving activity. Here, we studied the effects of preventive and therapeutic oral administration of Ang-(1-7) in a model of BLM-induced lung fibrosis in mice. Male C57Bl/6j mice were instilled with BLM and followed for weight loss and survival or euthanized to examine pulmonary inflammation, fibrosis, and lung function. For preventive treatment, mice were treated with Ang-(1-7) 1 h before instillation and then twice daily. We observed that preventive treatment with Ang-(1-7) decreased weight loss, inflammation and collagen deposition, increased survival, and ameliorated lung function. Therapeutic treatment with Ang-(1-7), starting 3 days after BLM instillation resulted in decreased inflammation, decreased collagen deposition, and ameliorated lung function, although the effects were of lower magnitude than the preventive treatment. Therapeutic treatment with Ang-(1-7) starting 7 or 14 days after BLM instillation failed to alter any of the changes observed. Therefore, although oral preventive treatment with Ang-(1-7) is effective to decrease pulmonary inflammation, fibrosis, and functional changes induced by BLM, therapeutic effects are much less significant, arguing against its use in patients with chronic fibrosis. It remains to be determined whether other proresolving molecules will have better therapeutic effects in the context of chronic pulmonary fibrosis.
Wide band resonators using SH mode of plate wave on LiNbO<inf>3</inf> (2012)

Currently, an ultra wide band resonator to realize a tunable filter with a wide tunable range is strongly required, because a mobile phone with multi-bands and a cognitive radio system require such a tunable filter to simplify their circuits. This time, authors realized resonators with ultra wide bandwidths of 29 % and a large impedance ratio of 98 dB between resonant and anti-resonant frequencies using an SH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> plate wave in a LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> plate. In addition, by applying their resonators to tunable filters, a band pass type tunable filter with a tunable range of 15 % and a ladder type one with a tunable range of 19 % were realized using capacitance of capacitors connected them.
The Validity of Rodent Brain-Ischemia Models Is Self-evident (1996)

The pointof contention implicit in the title of this article would, at first glance, appear to have little basis in reality. To challenge the validity of rodent studies of brain ischemia would seem on a par, for example, with questioning whether primate kidney cell cultures are a valid model for cultivating the human poliomyelitis virus. 1 A vast body of scientific literature spanning more than 3 decades attests to the utility of the rodent brain in modeling ischemic-anoxic injury. 2 Certain truths deserve emphasis here. As discomfiting as this may appear to certain members of our highly evolved species, it is nonetheless firmly established that there is a very high degree of genetic homology between humans and rodents. 3 Thus, the use of rodents to study genes, messages, enzymes, second messengers, receptors, and neurotransmitters would be expected to lead to insights more relevant than not to the human brain.
Reverberant speech enhancement using cepstral processing (1991)

Complex cepstral deconvolution is applied to acoustic dereverberation. It is found that traditional cepstral techniques fail in acoustic dereverberation because segmentation errors in the time domain prevent accurate cepstral computation. An algorithm for speech dereverberation which incorporates a novel approach to the segmentation and windowing procedure for speech is presented. Averaging in the cepstrum is exploited to increase the separation between the speech and impulse response. An estimate of the room impulse response is built, and a least squared error inverse filter is used to remove the estimated impulse response from the reverberant speech. Reduction of reverberation with this technique is demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
GaN-on-Si Power Technology: Devices and Applications (2017)

In this paper, we present a comprehensive review and discussion of the state-of-the-art device technology and application development of GaN-on-Si power electronics. Several device technologies for realizing normally off operation that is highly desirable for power switching applications are presented. In addition, the examples of circuit applications that can greatly benefit from the superior performance of GaN power devices are demonstrated. Comparison with other competing power device technology, such as Si superjunction-MOSFET and SiC MOSFET, is also presented and analyzed. Critical issues for commercialization of GaN-on-Si power devices are discussed with regard to cost, reliability, and ease of use.