gebhart/patrepeval huggingface dataset:
Fibroblasts maintain the phenotype and viability of the rat heparin-containing mast cell in vitro. (1985)

Rat serosal heparin-containing mast cells (HP-MC) were maintained in vitro for as long as 30 days when co-cultured with mouse skin-derived 3T3 fibroblasts. In contrast, when the mast cells were cultured alone, on fibronectin-, gelatin-, or dermal-collagen-coated dishes, on acid and heat-killed fibroblasts in the presence or absence of 24 hr fibroblast-conditioned medium, or on a monolayer of mouse serosal macrophages, they failed to adhere to the dishes, released significant amounts of their histamine and lactate dehydrogenase, and stained with trypan blue, indicating a loss of viability. The rat serosal HP-MC cultured with the 3T3 fibroblasts became so adherent to the fibroblasts that the two cell types could be separated from one another only by trypsinization. The cultured HP-MC stained with both alcian blue and safranin and continued to synthesize proteoglycan at a rate comparable to that of freshly isolated cells. The 35S-labeled proteoglycan synthesized by these cultured cells, like that produced by freshly isolated rat serosal HP-MC, was a 750,000 to 1,000,000 m.w. proteoglycan containing only heparin glycosaminoglycans of 50,000 to 100,000 m.w. When HP-MC were cultured for 1 wk with the fibroblasts and were then incubated for 5 min with a 1/20 dilution of rabbit anti-rat IgE, they generated and released an average of 22 +/- 10 ng (mean +/- SD, n = 5) of prostaglandin D2 per 10(6) cells and exocytosed a higher net percentage of their total histamine content (44 +/- 11% [mean +/- SD, n = 8]) than did cells just isolated from the animal (6 +/- 4% [mean +/- SD, n = 4]). As assessed by electron microscopy, many of the cultured HP-MC resembled freshly isolated cells except that some secretory granules had fused with one another in some cells. Morphologically, after activation the cultured HP-MC underwent compound exocytosis like freshly isolated cells. These results demonstrate that the in vivo differentiated rat HP-MC maintain their histology, morphology, immunologic responsiveness, histamine content, and ability to synthesize heparin proteoglycan when co-cultured with living fibroblasts.
Lamb Wave Focusing Transducer for Efficient Coupling to Wavelength-Scale Structures in Thin Piezoelectric Films (2018)

This paper describes the theoretical and experimental investigation of interdigitated transducers capable of producing focused acoustical beams in thin film piezoelectric materials. A mathematical formalism describing focused acoustical beams, lamb beams, is presented and related to their optical counterparts in two- and three-dimensions. A novel Fourier domain transducer design methodology is developed and utilized to produce near diffraction limited focused beams within a thin film AlN membrane. The properties of the acoustic beam formed by the transducer were studied by means of Doppler vibrometry implemented with a scanning confocal balanced homodyne interferometer. The Fourier domain modal analysis confirmed that 83% of the acoustical power was delivered to the targeted focused beam which was constituted from the lowest order symmetric mode, while 1% was delivered unintentionally to the beam formed from the anti-symmetric mode, and the remaining power was isotropically scattered. The transmission properties of the acoustic beams as they interact with devices with wavelength scale features were also studied, demonstrating minimal insertion loss for devices in which a subwavelength and pinhole apertures were included.
Design and implementation of a rover-back CANSAT (2011)

In this study, a CanSat with capability of returning back to target is designed amd implemented. The device is a part of project that has been implemented during the CLTP (CanSat Leadership Training Program) in Wakayama University. The CanSat is controlled by a state-of-the-art MBED 32-bit microcontroller. The main components are the pressure, ultrasonic, gps sensors and the 2.4 GHZ transmitter. The mission is planned for two stages which are flight back to the target by a paraglider and rovering on the ground on wheels. The process will be monitored on the ground station via the GoogleEarth software. The electronics&hardware design and the control algorithm is discussed in depth in this paper.
A general maximum likelihood framework for modulation classification (2002)

This paper deals with modulation classification. First, a state of the art is given which is separated into two classes: the pattern recognition approach and the maximum likelihood (ML) approach. Then we propose a new classifier called the general maximum likelihood classifier (GMLC) based on an approximation of the likelihood function. We derive equations of this classifier in the case of linear modulation and apply them to the MPSK/M'PSK problem. We show that the new tests are a generalisation of the previous ones using the ML approach, and don't need any restriction on the baseband pulse. Moreover the GMLC provides a theoretical foundation for many empirical classification systems including those systems that exploit the cyclostationary property of modulated signals.
Influence of polymer side chains on the photovoltaic performance of non-fullerene organic solar cells (2016)

The side chains of polymers had a great influence on their molecular packing, energy level, blend morphology and photovoltaic performance. The PCEs of 7.28% and 1.55% were obtained for alkoxy and alkylthio-substituted polymer based non-fullerene solar cells, respectively.
A Proautophagic Antiviral Role for the Cellular Prion Protein Identified by Infection with a Herpes Simplex Virus 1 ICP34.5 Mutant (2013)

The cellular prion protein (PrP) often plays a cytoprotective role by regulating autophagy in response to cell stress. The stress of infection with intracellular pathogens can stimulate autophagy, and autophagic degradation of pathogens can reduce their replication and thus help protect the infected cells. PrP also restricts replication of several viruses, but whether this activity is related to an effect on autophagy is not known. Herpes simplex virus 1 (HSV-1) effectively counteracts autophagy through binding of its ICP34.5 protein to the cellular proautophagy protein beclin-1. Autophagy can reduce replication of an HSV-1 mutant, Δ68H, which is incapable of binding beclin-1. We found that deletion of PrP in mice complements the attenuation of Δ68H, restoring its capacity to replicate in the central nervous system (CNS) to wild-type virus levels after intracranial or corneal infection. Cultured primary astrocytes but not neurons derived from PrP(-/-) mice also complemented the attenuation of Δ68H, enabling Δ68H to replicate at levels equivalent to wild-type virus. Ultrastructural analysis showed that normal astrocytes exhibited an increase in the number of autophagosomes after infection with Δ68H compared with wild-type virus, but PrP(-/-) astrocytes failed to induce autophagy in response to Δ68H infection. Redistribution of EGFP-LC3 into punctae occurred more frequently in normal astrocytes infected with Δ68H than with wild-type virus, but not in PrP(-/-) astrocytes, corroborating the ultrastructural analysis results. Our results demonstrate that PrP is critical for inducing autophagy in astrocytes in response to HSV-1 infection and suggest that PrP positively regulates autophagy in the mouse CNS.
Split gate MOSFET in BiCMOS power technology for logic level gate voltage application (2003)

Utilizing dual gate BiCMOS power technology (BPT), split gate oxide LDMOS and CMOS structures have been fabricated. These structures take advantage of low on-state channel resistance under the thin gate oxide at the source side and high breakdown voltage under the thick gate oxide at the drain side. Device simulation shows performance improvement in both R/sub ds-on/ at low V/sub gs/ and a reduction in field crowding in the reverse blocking state. Experimental characterization proves more efficient transistors can be integrated utilizing dual gate oxide at logic level gate drive while maintaining high breakdown voltage compared with single gate oxide devices.
Why Is Ice Slippery? (2005)

In 1859 Michael Faraday postulated that a thin film of liquid covers the surface of ice—even at temperatures well below freezing. Neglected for nearly a century, the dynamics of ice surfaces has now grown into an active research topic.
Addition of Organochromium Reagents to Carbonyl Compounds (2004)

Abstract Organochromium compounds can be prepared by two methods: (1) transmetallation from the corresponding organolithium, ‐magnesium, or –zinc compounds with chromium(III) halides, and (2) reduction of organic substrates, such as halides and unsaturated compounds with chromium(II) salts. The second method is usually the one ised because the first method suffers from low solubility of chromium(III) salts in ethereal solvents and from the difficulty of preparing organolithium compounds. Low‐valent chromium species are reducing agents. Reduction of various types of organic halides and compounds having unsaturated hetero‐hetero bonds with the chromium (II) species is discussed. Also described are the transmetallation to organochromium compounds from other organometallics, the nature of the carbon‐chromium bonds, and the X‐ray structure of chromium compounds. Reactions of organochromium reagents with carbonyl compounds and their scope and limitations are described. Included in this discussion are the geminal chromium reagents. Other reagents discussed are the chromium‐nickel compounds and alkylchromium and other organochromium reagents.
Optimizing resource utilization using transformations (1994)

The goal of the high level synthesis process for real time applications is to minimize the implementation cost, while still satisfying all timing constraints. In this paper, the authors present a combination of four conceptually simple, yet powerful, transformations: namely retiming, associativity, commutativity and inverse element law, which can help to further this goal. Since the minimization problem associated with these transformations is NP complete, a new fast iterative improvement probabilistic algorithm has been developed. The effectiveness of the proposed algorithm and the associated transformations is demonstrated in multiple ways: using standard benchmark examples, with the aid of statistical analysis and through a comparison with estimated minimal bounds.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A 6 ns 1 Mb CMOS SRAM with high-performance sense amplifier (2003)

A 1-Mb (256 K*4) SRAM with an access time of 6 ns using a 0.5- mu m CMOS technology is described. Fast access and low power dissipation are achieved by using a new nMOS source-controlled latched sense amplifier and a data output pre-reset circuit that reduces the output transition time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The role of tau in the pathological process and clinical expression of Huntington’s disease (2015)

Huntington's disease is a neurodegenerative disorder caused by an abnormal CAG repeat expansion within exon 1 of the huntingtin gene HTT. While several genetic modifiers, distinct from the Huntington's disease locus itself, have been identified as being linked to the clinical expression and progression of Huntington's disease, the exact molecular mechanisms driving its pathogenic cascade and clinical features, especially the dementia, are not fully understood. Recently the microtubule associated protein tau, MAPT, which is associated with several neurodegenerative disorders, has been implicated in Huntington's disease. We explored this association in more detail at the neuropathological, genetic and clinical level. We first investigated tau pathology by looking for the presence of hyperphosphorylated tau aggregates, co-localization of tau with mutant HTT and its oligomeric intermediates in post-mortem brain samples from patients with Huntington's disease (n = 16) compared to cases with a known tauopathy and healthy controls. Next, we undertook a genotype-phenotype analysis of a large cohort of patients with Huntington's disease (n = 960) with a particular focus on cognitive decline. We report not only on the tau pathology in the Huntington's disease brain but also the association between genetic variation in tau gene and the clinical expression and progression of the disease. We found extensive pathological inclusions containing abnormally phosphorylated tau protein that co-localized in some instances with mutant HTT. We confirmed this related to the disease process rather than age, by showing it is also present in two patients with young-onset Huntington's disease (26 and 40 years old at death). In addition we demonstrate that tau oligomers (suggested to be the most likely neurotoxic tau entity) are present in the Huntington's disease brains. Finally we highlight the clinical significance of this pathology by demonstrating that the MAPT haplotypes affect the rate of cognitive decline in a large cohort of patients with Huntington's disease. Our findings therefore highlight a novel important role of tau in the pathogenic process and clinical expression of Huntington's disease, which in turn opens up new therapeutic avenues for this incurable condition.
Preparation and characteristics of a crown ether polysiloxane stationary phase for capillary gas chromatography (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and characteristics of a crown ether polysiloxane stationary phase for capillary gas chromatographyCaiying. Wu, Chengming. Wang, Zhaorui. Zeng, and Xueran. LuCite this: Anal. Chem. 1990, 62, 9, 968–971Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://doi.org/10.1021/ac00208a013RIGHTS & PERMISSIONSArticle Views193Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (316 KB) Get e-Alerts Get e-Alerts
Polypharmacology in Precision Oncology: Current Applications and Future Prospects (2016)

Over the past decade, a more comprehensive, large-scale approach to studying cancer genetics and biology has revealed the challenges of tumor heterogeneity, adaption, evolution and drug resistance, while systems-based pharmacology and chemical biology strategies have uncovered a much more complex interaction between drugs and the human proteome than was previously anticipated. In this mini-review we assess the progress and potential of drug polypharmacology in biomarker-driven precision oncology. Polypharmacology not only provides great opportunities for drug repurposing to exploit off-target effects in a new single-target indication but through simultaneous blockade of multiple targets or pathways offers exciting opportunities to slow, overcome or even prevent inherent or adaptive drug resistance. We highlight the many challenges associated with exploiting known or desired polypharmacology in drug design and development, and assess computational and experimental methods to uncover unknown polypharmacology. A comprehensive understanding of the intricate links between polypharmacology, efficacy and safety is urgently needed if we are to tackle the enduring challenge of cancer drug resistance and to fully exploit polypharmacology for the ultimate benefit of cancer patients.
A Precise Multi-Exposure Image Fusion Method Based on Low-level Features (2020)

Multi exposure image fusion (MEF) provides a concise way to generate high-dynamic-range (HDR) images. Although the precise fusion can be achieved by existing MEF methods in different static scenes, the corresponding performance of ghost removal varies in different dynamic scenes. This paper proposes a precise MEF method based on feature patches (FPM) to improve the robustness of ghost removal in a dynamic scene. A reference image is selected by a priori exposure quality first and then used in the structure consistency test to solve the image ghosting issues existing in the dynamic scene MEF. Source images are decomposed into spatial-domain structures by a guided filter. Both the base and detail layer of the decomposed images are fused to achieve the MEF. The structure decomposition of the image patch and the appropriate exposure evaluation are integrated into the proposed solution. Both global and local exposures are optimized to improve the fusion performance. Compared with six existing MEF methods, the proposed FPM not only improves the robustness of ghost removal in a dynamic scene, but also performs well in color saturation, image sharpness, and local detail processing.
Bio-metals imaging and speciation in cells using proton and synchrotron radiation X-ray microspectroscopy (2009)

The direct detection of biologically relevant metals in single cells and of their speciation is a challenging task that requires sophisticated analytical developments. The aim of this article is to present the recent achievements in the field of cellular chemical element imaging, and direct speciation analysis, using proton and synchrotron radiation X-ray micro- and nano-analysis. The recent improvements in focusing optics for MeV-accelerated particles and keV X-rays allow application to chemical element analysis in subcellular compartments. The imaging and quantification of trace elements in single cells can be obtained using particle-induced X-ray emission (PIXE). The combination of PIXE with backscattering spectrometry and scanning transmission ion microscopy provides a high accuracy in elemental quantification of cellular organelles. On the other hand, synchrotron radiation X-ray fluorescence provides chemical element imaging with less than 100 nm spatial resolution. Moreover, synchrotron radiation offers the unique capability of spatially resolved chemical speciation using micro-X-ray absorption spectroscopy. The potential of these methods in biomedical investigations will be illustrated with examples of application in the fields of cellular toxicology, and pharmacology, bio-metals and metal-based nano-particles.
Estimation of Parameters for the Simulation of Foam Flow through Porous Media. Part 1: The Dry-Out Effect (2013)

We develop a method of estimating foam simulation parameters from laboratory experiments. Gas and surfactant solution are coinjected into sand packs at different experimental conditions in two systems. At steady state, saturation of the aqueous phase is shown to be relatively constant over a wide range of foam qualities. In order to obtain an accurate model fit at the transition foam quality, the difference between the foam model parameter fmdry and the transition water saturation Swt is identified and a method to precisely calculate Swt is developed. By superimposing contour plots of the transition foam quality and the foam apparent viscosity, one can estimate the reference mobility reduction factor (fmmob) and the critical water saturation (fmdry) using the STARS foam model. The parameter epdry, which regulates the abruptness of the foam dry-out effect, can be estimated by a transient (continuous gas injection) foam experiment.
Domain of metamers exciting intrinsically photosensitive retinal ganglion cells (ipRGCs) and rods (2012)

Any stimulus can be described as composed of two components-a fundamental color stimulus that controls the three cone responses and a metameric black that has no effect on cones but can drive photoreceptors other than cones [e.g., rods and melanopsin expressing retinal ganglion cells (ipRGCs)]. The Cohen and Kappauf [Am. J. Psychol. 95, 537 (1982)] method is extended to calculate the black metamer basis for a limited set of band spectra. Using seven colored LEDs, the method is exploited to produce real metamer illuminations that stimulate in parallel melanopsin expressing ipRGCs and rods, at most or at least. We have verified that the pupil diameter increases when the ipRGC and rod excitation is at a minimum. For 14 observers, the average relative increase is 12%.
Metabolic Changes in Blood and Liver of Dairy Cows During Either Feed Restriction or Administration of 1,3-Butanediol (1991)

Previous research has shown that a combination of feed restriction and dietary 1,3-butanediol starting at 14 d post-partum resulted in fatty liver and ketosis. Sixteen multiparous Holstein cows were used to determine effects of feed restriction or 1,3-butanediol as separate treatments. Treatments during d 14 to 42 postpartum were 1) control (ad libitum intake), 2) 20% feed restriction, or 3) control plus dietary 1,3-butanediol (5.5% of DM). From d 43 to 56, cows assigned to treatments 2 and 3 received a combination of feed restriction and butanediol. One cow on treatment 2 developed ketosis, but not fatty liver, after only 4 d of feed restriction. No other cows developed fatty liver or ketosis. Both treatments decreased milk production compared with controls. Feed restriction increased the extent of negative energy balance and caused transient increases in concentrations of NEFA, acetate, and beta-hydroxybutyrate in plasma. Concentrations of beta-hydroxybutyrate and insulin in plasma were increased by butanediol, which is a potent ketone body precursor. Concentration of glycogen in liver was less in feed-restricted cows, whereas glycogen and total lipid were greater in cows given butanediol separately. Gluconeogenic capacity of liver slices was not different among groups. Addition of 1,3-butanediol to in vitro incubation media decreased oxidation of propionate to CO2. Neither feed restriction nor dietary 1,3-butanediol as separate treatments induced the fatty liver and ketosis observed in earlier experiments in which the two treatments were given together.
The blood loss analyzer--a new way to estimate blood loss. (1983)

Regardless of the means used to estimate blood loss, clinical observation of the patient with frequent assessment of cardiovascular status is that basis of total management. It is very important that EBL be reported with some accuracy using a device that has the ability to weigh blood loss. Why? The overall mortality rate from blood transfusion has been reported to be as high as one death per 5000 units given. This is a highly subjective number. There are undoubtedly cases in which death has resulted from the administration of one unit of blood. However, the most common pattern would be one in which a patient received many units of blood and still died as a result of his primary disease. Until recently, blood loss determination was merely a function of estimation or clinical observation due to the previously mentioned drawbacks of manual scale systems. With new advances in computers, the ease at which blood soaked sponges can now be weighed and calculated can be as simple as a touch of a button.
Enterovirus 68 in Pediatric Patients Hospitalized for Acute Airway Diseases (2012)

Enterovirus 68 was detected in 10 respiratory specimens from pediatric patients hospitalized for acute wheezing or bronchitis during 2009 in the northeast of France. Viral loads ranged from 2 × 10(5) to 7.2 × 10(7) copies/ml. Alignment of 5' nontranslated regions and phylogenetic analysis of partial VP1 gene sequences show that these viruses clustered and belonged to clade C.