gebhart/patrepeval huggingface dataset:
Elevated Cholinesterase Activity in Patients with TIA and Other Thrombotic Disorders. (2009)

Abstract Abstract 2991 Poster Board II-967 Background. The natural function of ACTH in blood is not well defined. However elevated plasma level was reported in patients with chronic inflammation, suggesting as one of inflammatory markers. Erythrocytes possess membrane-bound acetylcholinesterase (AChE) while plasma contains a less specific cholinesterase (ChE). We reported at a previous meeting [Blood 2008, 112(11) Abst #3849] that AChE activity of RBC-derived microparticles (RMP) is 6 times higher than those in PMP. In this study we measured plasma ACTH levels in several groups and encountered unexpectedly high plasma ChE activities in patients with TIA and other thrombosis. Methods. (i) Patient population. A series of n=108 consenting patients were recruited sequentially having various disorders For purpose of analysis, they were divided in 2 main groups: n=53 with thrombosis (TBS), F/M 27/26; and n=55 non-TBS, F/M 24/31. Thrombosis group consists of venous and arterial thrombosis including those with TIA. Non TBS group consists of anemias, thrombocytopenias including ITP, MDS. (ii) Assay was essentially by Ellman's method. In our system, milli-absorbance units/min (mA/min) x 0.065 = umols substrate cleaved/min. Values reported here are in unitsof mA/min per mL plasma. Normal controls (NC, n=14) had a cutoff of 3000 mA/min per mL plasma, = mean +2SD. (iii) Sample handling. Platelet-poor plasma (PPP) was prepared by centrifuging 10 min at 1800 xg, then frozen in aliquots. For assay, it was diluted 1:20 with saline, then 5 uL and 10 uL were used in 96-well microtiter plate. Results: (i) Significantly higher ChE activity was observed in thrombosis (TBS) patients compared to non-TBS. Mean value ±SD in TBS was 2928 ±773, and in Non-TBS was 1897 ±713 (units as above). This difference was significant, p<0.001. (ii) When analyzed elevated levels of ACTH above 2SD of normal controls (n=26) between 2 groups, the TBS group had elevated ChE (>3000) in 30% of patients, while the Non-TBS had elevated ChE in 7.8%. (iii) Further analysis among thrombosis group revealed that the subgroup with neurological TBS (TIA, minor strokes) had the most consistent elevations of ACTH; 10 of15 with TIA group (66%) had ChE activities >3000. Summary/ Discussion. Although ChE and AChE in blood has long been studied, to our knowledge, this is the first report to show a relation between plasma ChE and thrombosis. Its elevation is very pronounce in thrombosis of the CNS, manifesting as TIA. Further study is warranted to elucidate how ChE is related to AChE of the CNS and on red cells. Disclosures: No relevant conflicts of interest to declare.
Sputter-grown Si quantum dot nanostructures for tandem solar cells (2012)

Abstract Silicon quantum dot (QD)-based ‘all-silicon’ tandem solar cells have emerged as a promising third generation photovoltaic approach to realize high-efficiency and cost effective solar cells. This approach exploits the quantum confinement effect of silicon QDs embedded in a dielectric matrix to engineer the effective electronic bandgap of a solar cell material. Research work in our group has shown that such a Si QD solar cell can be fabricated by co-sputtering of thin layers of Si-rich dielectric sandwiched between stoichiometric dielectric layers which crystallize to form Si QDs of uniform size on annealing. The Si-richness in the Si-rich layer plays an important role in formation of uniform size and shape. The matrix and barrier layer materials also affect the formation of Si QDs. The bandgap tunability of such Si QD superlattice structures has been clearly demonstrated by photoluminescence and electroluminescence measurements. Doping of Si QD layers has been achieved by impurity incorporation of P, Sb or B in the Si-rich layers. Strong evidence of effective doping has been demonstrated from the enhanced conductivity, from the dopant concentrations extracted from MOS structures and from the formation of rectifying p–n junctions which give an open circuit voltage ( V oc ) of 492 mV. The doping mechanism is more likely to be modified interface doping rather than direct doping to the Si QDs.
T-RBAC based Multi-domain Access Control Method in Cloud (2017)

Access control technology protects cloud from being accessed illegal. However, traditional access control technology cannot meet the new features of the cloud environment. In order to improve the deficiency of the current multi domain access control in timeliness and flexibility. This paper put forward a dynamic access control policy on the basis of task driving idea. New method combined the advantage of RBAC and task driving model, joined with limit aging and real time strategy synthesis. Comparative trial show that new policy had an advantage in flexibility and availability of multi-domain access control model.
Dual-Band Uniplanar CPW-Fed Monopole/EBG Combination With Bandwidth Enhancement (2012)

A novel low-profile uniplanar dual band coplanar waveguide (CPW)-fed monopole antenna/electromagnetic band-gap (EBG) combination, exhibiting bandwidth enhancement, is presented. Prototypes of the monopole antenna alone and combined with the EBG in the same layer are manufactured using laser micromachining. The characterization results of the manufactured prototypes in terms of return loss and radiation pattern measurements in an anechoic chamber are shown for comparison.
Nearly Optimal Adaptive Procedure with Change Detection for Piecewise-Stationary Bandit (2018)

Multi-armed bandit (MAB) is a class of online learning problems where a learning agent aims to maximize its expected cumulative reward while repeatedly selecting to pull arms with unknown reward distributions. We consider a scenario where the reward distributions may change in a piecewise-stationary fashion at unknown time steps. We show that by incorporating a simple change-detection component with classic UCB algorithms to detect and adapt to changes, our so-called M-UCB algorithm can achieve nearly optimal regret bound on the order of $O(\sqrt{MKT\log T})$, where $T$ is the number of time steps, $K$ is the number of arms, and $M$ is the number of stationary segments. Comparison with the best available lower bound shows that our M-UCB is nearly optimal in $T$ up to a logarithmic factor. We also compare M-UCB with the state-of-the-art algorithms in numerical experiments using a public Yahoo! dataset to demonstrate its superior performance.
The effects of a dentifrice containing a zinc salt and a non‐cationic antimicrobial agent on plaque and gingivitis (1987)

The antiplaque potential of metal salts in mouthwashes or dentifrices has been previously demonstrated. The purpose of the present investigation was to establish the effects on plaque and gingival health of a dentifrice which contained a combination of the metal salt, zinc citrate, and the anti-microbial agent, Triclosan. Plaque growth was reduced by a dentifrice which contained either zinc citrate or triclosan, but greater inhibition was achieved with dentifrices which contained both agents. A 4-day non-brushing study in which slurries of the dentifrice were used, confirmed that the test dentifrice which contained 1% zinc citrate and 0.5% Triclosan reduced the accumulation of plaque by 50%. In a double-blind crossover study of 28 days duration, a significant reduction in plaque accumulation and an improvement in gingival health was demonstrated for the test dentifrice compared to the placebo. Further analysis of the data indicated that the dentifrice was most efficacious for participants who brushed ineffectively. Also, the greatest benefit was obtained by subjects that used the largest amount of dentifrice.
GAS MAIN SENSOR AND COMMUNICATIONS NETWORK SYSTEM (2004)

Automatika, Inc. was contracted by the Department of Energy (DOE) and with co-funding from the New York Gas Group (NYGAS), to develop an in-pipe natural gas prototype measurement and wireless communications system for assessing and monitoring distribution networks. In Phase II of this three-phase program, an improved prototype system was built for low-pressure cast-iron and high-pressure steel (including a no-blow installation system) mains and tested in a serial-network configuration in a live network in Long Island with the support of Keyspan Energy, Inc. The experiment was carried out in several open-hole excavations over a multi-day period. The prototype units (3 total) combined sensors capable of monitoring pressure, flow, humidity, temperature and vibration, which were sampled and combined in data-packages in an in-pipe master-repeater-slave configuration in serial or ladder-network arrangements. It was verified that the system was capable of performing all data-sampling, data-storage and collection as expected, yielding interesting results as to flow-dynamics and vibration-detection. Wireless in-pipe communications were shown to be feasible and the system was demonstrated to run off in-ground battery- and above-ground solar power. The remote datalogger access and storage-card features were demonstrated and used to log and post-process system data. Real-time data-display on an updated Phase-I GUI was used for in-field demonstration and troubleshooting.
Synthesis from VHDL (2003)

The VHDL Synthesis System (VSS) uses VHDL dataflow or behavioral descriptions as input and outputs a structural description of generic components. This structural description is converted into a schematic and captured by the microarchitecture and logic optimization system for technology mapping and constraint-driven optimization. VSS allows a designer to modify the compiled design by changing the input description, selecting optimization and mapping strategies, or graphically changing the generated design schematic. Redesign to new technologies can be accomplished by changing only the component library.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Recombinant anti-vascular endothelial growth factor fusion protein efficiently suppresses choridal neovasularization in monkeys. (2008)

KH902 presents high affinity with VEGF and inhibitory activity on the proliferation of human umbilical vein endothelial cells (HUVECs) induced by VEGF. A single 300 microg or 500 microg KH902 intravitreal injection effectively inhibited leakage and growth of the CNV in rhesus monkeys without evidence of toxicity. This study suggests that KH902 has promise as a local antiangiogenic treatment of CNV.
Deep learning based frameworks for image super-resolution and noise-resilient super-resolution (2017)

Our paper is motivated from the advancement in deep learning algorithms for various computer vision problems. We are proposing a novel end-to-end deep learning based framework for image super-resolution. This framework simultaneously calculates the convolutional features of low-resolution (LR) and high-resolution (HR) image patches and learns the non-linear function that maps these convolutional features of LR image patches to their corresponding HR image patches convolutional features. Here, proposed deep learning based image super-resolution architecture is termed as coupled deep convolutional auto-encoder (CDCA) which provides state-of-the-art results. Super-resolution of a noisy/distorted LR images results in noisy/distorted HR images, as super-resolution process gives rise to spatial correlation in the noise, and further, it cannot be de-noised successfully. Traditional noise resilient image super-resolution methods utilize a de-noising algorithm prior to super-resolution but de-noising process gives rise to loss of some high-frequency information (edges and texture details) and super-resolution of the resultant image provides HR image with missing edges and texture information. We are also proposing a novel end-to-end deep learning based framework to obtain noise resilient image super-resolution. Proposed end-to-end deep learning based framework for noise resilient super-resolution simultaneously perform image de-noising and super-resolution as well as preserves textural details. First, stacked sparse de-noising auto-encoder (SSDA) was learned for LR image de-noising and proposed CDCA was learned for image superresolution. Then, both image de-noising and super-resolution networks were cascaded. This cascaded deep learning network was employed as one integral network where pre-trained weights were serving as initial weights. The integral network was end-to-end trained or fine-tuned on a database having noisy, LR image as an input and target as an HR image. In fine-tuning, all layers of the combined end-to-end network was jointly optimized to perform image de-noising and super-resolution simultaneously. Experimental results show that proposed noise resilient super-resolution framework outperforms the conventional and state-of-the-art approaches in terms of PSNR and SSIM metrics.
Cellular network capacity planning using dependency-based data modeling (2002)

Providing an adequate number of radio channels is an important task of cellular network capacity planning and service provisioning. This task involves analyses of historic correlations between traffic and capacity, projecting future traffic demand, and developing optimum plans for providing radio channels to support that demand. It is a domain in which analytical models are intermixed with experienced-based decision making. The task becomes even more complicated when digital networks are planned due to insufficient practical experience.
Applying Adaptive Role-Based Model to Self-Adaptive System Constructing Problems: A Case Study (2011)

When computational process occurs in uncertain environments, the environmental changes often cause unpredictable influence on the computation. Self-adaptive software is one of the possible ways to tackle and handle this motivation. It evaluates its own behavior and surrounding environment, and adapts itself when the evaluation indicates that it is not accomplishing what the system is intended to do, or when better functionality is possible. Since one of the objectives of role models is to support object adaptation to the environment through role binding mechanism, it is expected that role modeling can be conveniently used to build self-adaptive systems. This paper provides some essential features or mechanisms of self-adaptive systems which are intended to be captured by adaptive role models. We propose Self-Epsilon model, an extension of our developed role-based model Epsilon, to combine and integrate all those features with role-based mechanisms into a single model. This paper also shows how the model can be applied to practically design and implement self-adaptive systems. We illustrate our approach through a case study of a simplified system of coordinated traffic jam monitoring used in some related work. The evaluation shows the reasonable and acceptable scalability of our model implementation in the framework.
Intranasal Vaccination with a Recombinant Vesicular Stomatitis Virus Expressing Cottontail Rabbit Papillomavirus L1 Protein Provides Complete Protection against Papillomavirus-Induced Disease (2002)

Immunizations with live recombinant vesicular stomatitis viruses (rVSV) expressing foreign viral proteins have successfully protected animals from challenges with several heterologous viruses. We developed an rVSV expressing the major capsid protein (L1) of cottontail rabbit papillomavirus (CRPV) and tested the efficacy of protection following CRPV challenge. An rVSV expressing L1 of CRPV (VSV-L1) was characterized for the protective ability afforded by intranasal, intradermal, or intramuscular vaccination in rabbits subsequently challenged with CRPV. Protein expression of L1 in VSV-L1 was confirmed by radioimmunoprecipitation assays. Nuclear localization of L1 was demonstrated by indirect immunofluorescence assays. Immunized rabbits elicited significant VSV neutralization and VLP-L1 enzyme-linked immunosorbent assay titers. VSV-L1 vaccination was not associated with weight loss or any other adverse clinical signs in the rabbit model. VSV shedding in nasal secretions occurred in some rabbits, peaking at 4 to 6 days after intranasal vaccination, with no further shedding after day 6. Specific humoral immunity to the L1 protein was consistently seen after a single VSV-L1 vaccination when administered through an intradermal or intramuscular route or after a boost via the intranasal route. Rabbits were completely protected from CRPV-induced papillomas after VSV-L1 vaccination and boost given intranasally or intramuscularly. Vaccination with VSV-L1 is a novel approach to prevent papillomavirus-induced disease and demonstrates a potential strategy for developing a human papillomavirus vaccine that can be given without injection.
Time in Distributed Real-Time Systems (2018)

A real-time music system is responsible for deciding what happens when, when each task runs and each message takes effect. This question becomes acute when there are several classes of tasks running and intercommunicating: user interface, control processing, and audio, for example. We briefly examine and classify past approaches and their applicability to distributed systems, then propose and discuss an alternative. The shared access to a sample clock that it requires is not trivial to achieve in a distributed system, so we describe and assess a way to do so.
Co-administration of Carbamazepine with Eslicarbazepine Acetate Decreases Eslicarbazepine Exposure: A Population Pharmacokinetic Analysis (P3.243) (2014)

OBJECTIVE: Investigate the effects of co-administered carbamazepine (CBZ) on the pharmacokinetics of eslicarbazepine, the major active metabolite of eslicarbazepine acetate (ESL). BACKGROUND: ESL is a novel once-daily (QD) anticonvulsant, extensively converted after oral administration to eslicarbazepine, which blocks voltage-gated sodium- and calcium-channels. DESIGN/METHODS: A population pharmacokinetic model was developed using 24h sampling data from 11 Phase I and 3 Phase III studies in which ESL was dosed QD at 400-1200mg. Exponential error models described inter-individual variability (IIV) in absorption rate constant (ka), apparent oral clearance (CL/F) and apparent volume of distribution (V/F). Two additive plus proportional error models corrected for differences in residual variability between Phase I and III data. Effects of concomitant CBZ were assessed by presence/absence, and then by dose. RESULTS: Eslicarbazepine pharmacokinetics were described by a one-compartment model with first-order absorption and elimination. Estimates had good precision, IIV was large (ka) or moderate (CL/F, V/F), and residual variability was moderate (Phase III) or low (Phase I). Estimated base eslicarbazepine CL/F, V/F, and first-order absorption half-life (t1/2) were 2.43L/h, 61.3L, and 0.296h, respectively. Compared with no concomitant antiepileptic drugs, CBZ increased eslicarbazepine CL/F (by 33.4-52.5% for CBZ doses between 200mg BID and 400mg TID) and decreased eslicarbazepine area-under-the-concentration-time-curve at steady-state (AUCss; by 25.1-34.4% for CBZ doses between 200mg BID and 400mg TID [median decrease=30.8% with CBZ 400mg BID]). CONCLUSIONS: Co-administration of CBZ with ESL decreases eslicarbazepine exposure. Adjustment of ESL dose may be necessary when CBZ is co-administered, based on the need for additional seizure control. Study Supported by: Sunovion Pharmaceuticals Inc.
Therapeutic strategies to remodel immunologically cold tumors (2020)

Immune checkpoint inhibitors (ICIs) induce a durable response in a wide range of tumor types, but only a minority of patients outside these 'responsive' tumor types respond, with some totally resistant. The primary predictor of intrinsic immune resistance to ICIs is the complete or near-complete absence of lymphocytes from the tumor, so-called immunologically cold tumors. Here, we propose two broad approaches to convert 'cold' tumors into 'hot' tumors. The first is to induce immunogenic tumor cell death, through the use of oncolytic viruses or bacteria, conventional cancer therapies (e.g. chemotherapy or radiation therapy) or small molecule drugs. The second approach is to target the tumor microenvironment, and covers diverse options such as depleting immune suppressive cells; inhibiting transforming growth factor-beta; remodelling the tumor vasculature or hypoxic environment; strengthening the infiltration and activation of antigen-presenting cells and/or effector T cells in the tumor microenvironment with immune modulators; and enhancing immunogenicity through personalised cancer vaccines. Strategies that successfully modify cold tumors to overcome their resistance to ICIs represent mechanistically driven approaches that will ultimately result in rational combination therapies to extend the clinical benefits of immunotherapy to a broader cancer cohort.
Musical Biography and the Myth of the Muse (2016)

Recent scholarship by Marcia Citron and others has explored various agents responsible for enforcing the historical effacement of women as composers,2 but the specific role played by biographical writings has less frequently been the focus of detailed critique, perhaps because the broader investigation of musical biography for its historiographical significance remains itself a largely untapped area of musicological enquiry. Yet the genre flourished in the hagiographical environment of the nineteenth century so crucial to canon formation: since it fundamentally embodied a form of hero-worship in which the whitewashed lives of select individuals were placed on lofty pedestals, it was ideally suited to reinforcing music history’s top-down predication upon an elite set of idolised Great Men. Jim Samson has explored the cultivation of notions of greatness and creative genius as a hallmark of nineteenth-century music history; William Weber has comprehensively traced the multi-faceted trends that led, inter alia, to the century’s establishing a historical repertory of great works by (often deceased) classical composers.3 Musical biography likewise became complicit in the processes of construction and subsequent perpetuation of male-dominated musical canons of wider conceptual importance; as Ruth Solie has remarked of the genre, ‘whatever spin is put upon the story, on the level of cultural myth it remains irremediably a male story’.4