gebhart/patrepeval huggingface dataset:
Tuning the weights in WFQ schedulers for the maximization of carried best effort traffic (2003)

A configuration scheme for networks with weighted fair queuing (WFQ) schedulers that maximizes the amount of best effort traffic carried is presented. The cases where traffic flows would congest critical links and lower network performance are considered. The proposal is based on a linear programming formulation. The solution provides the weights that will make the best effort flows controllable and reach optimal situation. A formulation that reaches a trade-off between network utilization, fairness, and user satisfaction is offered.
IMMUNOGLOBULIN CLASS AND SPECIFICITY OF ANTIBODIES CAUSING POSITIVE T CELL CROSSMATCHES (1986)

A group of 42 renal transplants performed in the presence of a T-cell-positive crossmatch were analyzed to determine the class and specificity of the donor-reactive cytotoxic antibodies. Dithiothreitol (DTT) was used to reduce IgM antibodies and a monoclonal antibody directed at a monomorphic determinant present on all HLA class I antigens (PA2.6) was used to inhibit cytotoxicity of anti-HLA class I antibodies. Sera from 26 of the positive crossmatches were considered to be autoreactive, and the positive crossmatch proved to be due to IgM and not directed at HLA class I in each case. One year graft survival was 100% in the 5 living-related and 60% in the 21 cadaver donor transplants, of which 10 were regrafts. Of the 42 positive crossmatches, 16 were not due to autoantibody. One was positive in the current serum taken at the time of transplantation, and this graft was rejected hyperacutely, while 15 were positive with peak but not current serum samples. Of the positive crossmatches, 12 were inhibited by PA2.6 demonstrating that they were directed at HLA class I antigens. PA2.6 inhibition could not be shown in 3 and in 1 DTT reduction was technically unsatisfactory. While 4 of the 7 positive crossmatches due to IgM antibodies were successful, the 7 transplants performed with positive crossmatches due to IgG antibodies all failed. DTT reduction and inhibition of cytotoxicity by PA2.6 helps to define positive crossmatches with donor T cells that are not associated with graft failure. Transplantation in the presence of a peak positive T cell crossmatch due to an anti-HLA antibody might only be successful if the antibody in the peak serum is of the IgM class.
Measurement of pulse wave velocity: site matters (2007)

Carotid-femoral PWV is a better indicator of atherosclerosis than either carotid-radial or femoral-posterior tibial PWV, and should be used preferentially in studies of atherosclerosis and in stratifying risk in clinical settings.
Application of single phase sectionalizers with three-phase reclosers to increase reliability (2004)

Until recently, one of the only viable rural or suburban feeder protection schemes beyond the loading limits of the 70-amp hydraulic Automatic Circuit Recloser (recloser) involved the use of a three phase electronic recloser with phase and ground curve settings. The three phase reclosers could only operate as three phase or single phase reclose and three phase lockout. On feeders that connected many single phase customers, this three phase operating characteristic proved to be costly with respect to reliability and, more specifically, to the number of customers experiencing an outage. The fault on one conductor of the three phase line from a substation would affect the other two phases until a crew could isolate the fault and reenergize the recloser. This report summarizes the investigation of using single phase sectionalizers on the load side of the three phase reclosers to provide sectionalizing of the faulted phase while leaving the other two phases energized.
Immunoreactivity for cadherins, HGF/SF, met, and erbB‐2 in pleural malignant mesotheliomas (2000)

Expression of N-cadherin supports the diagnosis of malignant mesothelioma and use of appropriate antibodies would be a useful addition to a diagnostic antibody panel. Focal staining for E-cadherin does not exclude mesothelioma. Signalling pathways mediated via met and erbB-2 may play a role in the growth and spread of malignant mesotheliomas.
Process Scale Liquid Chromatography (1994)

Chromatography systems, design and control the practical application of theory in preparative liquid chromatography alternative modes of operation of chromatography columns in the process situation process scale size exclusion chromatography polymers and their application in liquid chromatography biochemcial application of process scale ion-exchange liquid chromatography instrumental design and separation in large-scale industrial supercritical fluid chromatography scaling-up of supercritical fluid chromatography to large-scale separation affinity chromatography and its applications in large-scale separations.
Mood stabilizers in hospitalized children with bipolar disorder: A retrospective review (2003)

A paucity of naturalistic data supported a rationale for the present retrospective review of clinical changes during hospitalization in 44 bipolar pre-adolescents, treated with monotherapy lithium, carbamazepine (CBZ) or divalproex sodium (DVP). Daily staff progress notes and discharge summaries on each patient were read by four trained clinicians blind to treatment group, and rated according to the Clinical Global Impression Improvement (CGI-I) scale. Consensus rating was measured by kappa reliability. Data were analyzed using a general linear model (sas mixed) analysis of variance (anova) with repeated measures. The medication groups did not differ in length of hospitalization, overall severity of illness at the time of admission, or comorbidity. Prior treatment was considered as a covariate. Each group approached serum therapeutic levels at day 7 of the medication period. The estimated mean CGI-I scores for CBZ were systematically higher (i.e. worse) than those for lithium and DVP, which overlapped and crossed over time. The difference became increasingly apparent and was statistically significant by week 2 (P = 0.036). The present study was limited in that the sample sizes, particularly in the case of CBZ, were small, commensurate with the low prevalence of the disorder. Lack of structured interviews, as an independent assessment of diagnoses was an intrinsic limitation of the study. Although constrained by its retrospective nature, our findings suggest that by week 2 of hospitalization both lithium and DVP may be more efficacious than CBZ in bipolar pre-adolescents. Any significant finding must be viewed as tentative and subject to confirmation in other studies.
Flue Gas CO2 Mineralization Using Thermally Activated Serpentine: From Single- to Double-step Carbonation (2014)

This communication explores the carbonation potential of activated serpentine at flue gas conditions. A first series of single-step batch experiments was performed varying the temperature and the slurry density to systematically assess the precipitation regime of the relevant Mg-carbonates and the fate of the Si species in solution. The results suggested that the reaction progress was hindered by a passivating layer of re-precipitated silica, quartz, or carbonates, as well as by equilibrium limitations. Among several strategies that were tested to overcome these limitations, a simple double-step process that is driven by a temperature swing in combination with a low-level CO2 pressure swing is presented. Exploratory experiments are shown that prove the viability of our process, first by applying a discontinuous method, and secondly by implementing a methodology to cycle the liquid phase continuously between a dissolution reactor and a precipitator. In this way, it was possible to produce highly pure Mg-carbonates that may serve various industries.
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1–mediated vascular endothelial barrier enhancement (2009)

Activated protein C (APC) has both anticoagulant activity and direct cell-signaling properties. APC has been reported to promote cancer cell migration/invasion and to inhibit apoptosis and therefore may exacerbate metastasis. Opposing these activities, APC signaling protects the vascular endothelial barrier through sphingosine-1-phosphate receptor-1 (S(1)P(1))activation, which may counteract cancer cell extravasation. Here, we provide evidence that endogenous APC limits cancer cell extravasation, with in vivo use of monoclonal antibodies against APC. The protective effect of endogenous APC depends on its signaling properties. The MAPC1591 antibody that only blocks anticoagulant activity of APC does not affect cancer cell extravasation as opposed to MPC1609 that blocks anticoagulant and signaling properties of APC. Combined administration of anti-APC antibodies and S(1)P(1) agonist (SEW2871) resulted in a similar number of pulmonary foci in mice in presence and absence of APC, indicating that the protective effect of APC depends on the S(1)P(1) pathway. Moreover, endogenous APC prevents cancer cell-induced vascular leakage as assessed by the Evans Blue Dye assay, and SEW2871 treatment reversed MPC1609-dependent vascular leakage. Finally, we show that cancer cells combined with MPC1609 treatment diminished endothelial VE-cadherin expression. In conclusion, endogenous APC limits cancer cell extravasation because of S(1)P(1)-mediated VE-cadherin-dependent vascular barrier enhancement.
Noninvasive Measurement of Absolute Renal Perfusion by Contrast Medium-Enhanced Magnetic Resonance Imaging (2003)

Using a flow-sensitive calibration, an accurate arterial input function can be measured from the blood MR signal and used in a realistic model to assess the RP. There was a good correlation between the MR-derived RP and the renal artery blood flow measured by the flow-meter. This experimental study validates absolute RP quantification by MRI and contrast media injection and justifies further clinical studies.
A Precise Bandwidth Control Arbitration Algorithm for Hard Real-Time SoC Buses (2007)

On an SoC bus, contentions occur while different IP cores request the bus access at the same time. Hence an arbiter is mandatory to deal with the contention issue on a shared bus system. In different applications, IPs may have real-time and/or bandwidth requirements. It is very difficult to design an arbitration algorithm to simultaneously meet these two requirements. In this paper, we propose an innovative arbitration algorithm, RB_lottery, to meet both of the requirements. It can provide not only the hard real-time guarantee but also the precise bandwidth controllability. The experimental results show that RBJottery outperforms several well-known existing arbitration algorithms.
Identification of a Ubiquitous Family of Membrane Proteins and Their Expression in Mouse Brain (2000)

A family of genes encoding membrane proteins with a unique structure has been identified in DNA and cDNA clones of various eukaryotes ranging from yeast to human. The nucleotide sequences of three novel cDNAs from Drosophila melanogaster and mouse were determined. The amino acid sequences of the two mouse proteins have human homologs. The gene (TMS1) encoding the yeast member of this family was disrupted, and the resulting mutant showed no significant phenotype under several stress conditions. The expression of the mouse genes TMS-1 and TMS-2 was examined by in situ hybridization of sections from brain, liver, kidney, heart and testis of an adult mouse as well as in a 1-day-old whole mouse. While the expression of TMS-2 was found to be restricted to the central nervous system, TMS-1 was also expressed in kidney and testis. The expression of TMS-1 and TMS-2 in the brain overlapped and was localized to areas associated with glutamatergic excitatory neurons, such as the hippocampus and cerebral cortex. High-magnification analysis indicated that both mRNAs are expressed in neurons. Semiquantitative analysis of mRNA expression was performed in various parts of the brain. The conservation, unique structure and localization in the mammalian brain of this novel protein family suggest an important biological role.
Prime numbers and output codes (2002)

In this paper, the prime number encoding scheme is proposed for representing the supervisory class signals at the output layer of multilayered feedforward networks. The notion of prime number encoding stems from the idea that the module representations with respect to two appropriately chosen primes can uniquely represent any bounded integer value. In particular, the derived prime number encoding scheme is a viable replacement for the conventional 1-per-class coding scheme used for indexing tasks. Face recognition experiments performed using a 24-face database, and word-spotting experiments performed with the TIMIT speech database, suggest that the prime number encoding scheme is beneficial for indexing purposes, not only from the point of parameter reduction, but also in terms of recognition performance.
Influence of Various Antimicrobial Agents on the Chemiluminescence of Phagocytosing Human Granulocytes (1986)

In a standardized experimental model 51 antimicrobial agents were coincubated with polymorphonuclear granulocytes (PNG) of healthy human donors and then screened for a modulation of chemiluminescence (CL) reaction during zymosan phagocytosis. Initial studies with low, therapeutic and high, nontherapeutic conentrations showed CL suppression by amoxicillin, tetracycline, doxycycline, trimethoprim, sulfamethoxazol, clindamycin, fusidic acid, rifampicin, isoniazid and amphotericin B, yet stimulation of CL reaction by ceftriaxone, enoxacin, and norfloxacin. Dose-effect relationships for most of these substances showed a sigmoid-like graph with little influence upon most of the therapeutic range, but markedly increasing suppression (or stimulation) from a certain ‘threshold’ concentration. For certain substances this curve might indicate a narrowed therapeutic range of antimicrobial chemotherapy due to impairment of phagocytic functions.
[Stanniocalcin-1 (STC-1) as a molecular marker for human cancer]. (2006)

Stanniocalcin (STC) is a glycoprotein hormone that regulates calcium levels in fish. The related human protein stanniocalcin-1 (STC-1) is expressed in multiple organs including the ovary, prostate, kidney, and thyroid. Human STC-1 expression is enhanced by neural cell differentiation, bone formation, and cell proliferation. Recently, quantitative RT-PCR analysis showed high levels of STC-1 mRNA in the blood of patients with cancer as compared with those in the blood of volunteers without cancer. The STC-1 mRNA expression in blood is closely related to tumor size in breast cancer, micrometastases of hepatocellular carcinoma, and minimal residual disease in leukemia. This brief review describes the diagnostic significance of STC-1 as a molecular marker for human cancer.
Candida Urinary Tract Infections—Treatment (2011)

In many instances a report from the clinical laboratory indicating candiduria represents colonization or procurement contamination of the specimen and not invasive candidiasis. Even if infection of the urinary tract by Candida species can be confirmed, antifungal therapy is not always warranted. Further investigation may reveal predisposing factors, which if corrected or treated, result in the resolution of the infection. For those with symptomatic urinary tract infections (UTIs), the choice of antifungal agent will depend upon the clinical status of the patient, the site of infection, and the pharmacokinetics and pharmacodynamics of the agent. Because of its safety, achievement of high concentrations in the urine, and availability in both an oral and intravenous formulation, fluconazole is preferred for the treatment of Candida UTIs. Flucytosine is concentrated in urine and has broad activity against Candida spp, but its use requires caution because of toxicity. Low-dose amphotericin B may be useful for Candida UTIs in selected patients. The role of echinocandins and azoles that do not achieve measurable concentrations in the urine is not clear. Small case series note some success, but failures have also occurred. Irrigation of the bladder with antifungal agents has limited utility. However, with fungus balls, irrigation of the renal pelvis through a nephrostomy tube can be useful in combination with systemic antifungal agents.
A three-parameters-only MOSFET subthreshold current CAD model considering back-gate bias and process variation (1997)

In this paper we introduce a new subthreshold conduction CAD model for simulation of VLSI subthreshold CMOS analog circuits and systems. This model explicitly formulates the back-gate bias effect and preserves the original advantages of the existing four-parameter model while reducing the fitting parameter number down to three. A transparent relationship between the fitting parameters and the process parameters has been derived, and its correlation with a recently widely used CAD model as well as with a well-known two-parameter model has been established. Our extensive measurement work on n-channel MOSFET's has highlighted the potential of the model in handling the variations in the subthreshold I-V characteristics at different back-gate biases arising from process variations. The mismatch analysis has further been successfully performed with emphasis on the reverse back-gate bias effect. In summary, the proposed model can serve as a promising alternative in the area of VLSI subthreshold CMOS analog circuit simulation.
Complete Genome Sequence of Mayaro Virus ( <i>Togaviridae, Alphavirus</i> ) Strain BeAr 20290 from Brazil (2015)

We report here the complete genome sequence of Mayaro virus strain BeAr 20290 isolated from Haemagogus mosquitoes in 1960. The sequence presented here includes all nonstructural and structural proteins and the 5'- and 3'-untranslated (UTR) regions.
Microfluidic Long-Term Gradient Generator with Axon Separation Prototyped by 185 nm Diffused Light Photolithography of SU-8 Photoresist (2018)

We have developed a cast microfluidic chip for concentration gradient generation that contains a thin (~5 µm² cross-sectional area) microchannel. The diffusion of diffused 185 nm ultraviolet (UV) light from an inexpensive low-pressure mercury lamp exposed a layer of the SU-8 photoresist from the backside and successfully patterned durable 2 µm-high microchannel mold features with smooth bell-shaped sidewalls. The thin channel had appropriate flow resistance and simultaneously satisfied both the rapid introduction of test substance and long-term maintenance of gradients. The average height and width at the half height of the channel, defined by a 2 µm-wide line mask pattern, were 2.00 ± 0.19 µm, and 2.14 ± 0.89 µm, respectively. We were able to maintain the concentration gradient of Alexa Fluor 488 fluorescent dye inside or at the exit of the thin microchannel in an H-shaped microfluidic configuration for at least 48 h. We also demonstrated the cultivation of chick embryo dorsal root ganglion neuronal cells for 96 h, and the directional elongation of axons under a nerve growth factor concentration gradient.
Advances in the selection of transgenic plants using non‐antibiotic marker genes (2001)

Production of transgenic plants started more than a decade ago, but it is still a time-consuming operation. One of the critical points is the selection procedure used for the recovery of transgenic shoots after transformation. Moreover, as more transgenic traits are to be incorporated into crops that already have been transformed, it is clear that there is a need for new methods with higher efficiencies. In this article, recently developed selection systems are reviewed. They differ from conventional selection techniques as they are based on supplementing the transgenic cells with a metabolic advantage rather than killing the non-transgenic cells. In many cases, these new selection systems have been found to be superior to conventional methods.
Layer-Transfer Process Modifications for Fabricating Hybrid Crystal Orientation Engineered Substrates (2006)

Successful integration of hybrid-orientation substrates into high-volume production requires a layer-transfer process to prepare the substrates. Modifications of SiGen's NanoCleave/spl trade/ layer-transfer process were tested for compatibility to cleave and smooth [110] films, produce multi-stack composites and prepare direct bonded film structures. The technology has the promise to be a viable manufacturing process for strained and unstrained hybrid-orientation substrates used for deep submicron mobility enhancement.
Towards roll-to-roll manufacturing of polymer photonic devices (2014)

Traditionally, polymer photonic devices are fabricated using clean-room processes such as photolithography, e-beam lithography, reactive ion etching (RIE) and lift-off methods etc, which leads to long fabrication time, low throughput and high cost. We have utilized a novel process for fabricating polymer photonic devices using a combination of imprinting and ink jet printing methods, which provides high throughput on a variety of rigid and flexible substrates with low cost. We discuss the manufacturing challenges that need to be overcome in order to realize true implementation of roll-to-roll manufacturing of flexible polymer photonic systems. Several metrology and instrumentation challenges involved such as availability of particulate-free high quality substrate, development and implementation of high-speed in-line and off-line inspection and diagnostic tools with adaptive control for patterned and unpatterned material films, development of reliable hardware, etc need to be addressed and overcome in order to realize a successful manufacturing process. Due to extreme resolution requirements compared to print media, the burden of software and hardware tools on the throughput also needs to be carefully determined. Moreover, the effect of web wander and variations in web speed need to accurately be determined in the design of the system hardware and software. In this paper, we show the realization of solutions for few challenges, and utilizing these solutions for developing a high-rate R2R dual stage ink-jet printer that can provide alignment accuracy of <10m at a web speed of 5m/min. The development of a roll-to-roll manufacturing system for polymer photonic systems opens limitless possibilities for the deployment of high performance components in a variety of applications including communication, sensing, medicine, agriculture, energy, lighting etc.
Vitamin E deficiency does not induce compensatory antioxidant increases in central nervous system tissue of apolipoprotein E-deficient mice (2003)

Compensatory upregulation in endogenous antioxidants has been shown to accompany certain genetic and dietary deficiencies that promote oxidative stress, including that related to Alzheimer's disease. We compared antioxidant levels in brain tissue of normal and transgenic mice lacking apolipoprotein E following dietary deprivation of vitamin E or folate. As described previously, ApoE-deficient mice displayed increased levels of the endogenous antioxidant glutathione as compared to normal mice, and increased these levels further following folate deprivation. By contrast, glutathione was depleted following vitamin E deprivation in brain tissue of normal and ApoE-deficient mice. TBAR analyses confirmed increased oxidative damage following vitamin E deprivation. However, combined deprivation of folate and vitamin E resulted in levels of glutathione intermediate between those observed following deprivation of either agent, indicating that the lack of compensatory increase in glutathione following vitamin E deprivation was not due to overt neurotoxicity. Similar results were observed for total antioxidant levels in brain tissue. The differential response to vitamin E and folate deprivation is consistent with the possibility that specific differences in oxidative damage may result from deficiencies in either of these agents. The lack of a compensatory response to vitamin E deprivation highlights the importance of dietary vitamin E in prevention of chronic neurodegeneration.