gebhart/patrepeval huggingface dataset:
Strain rate effects on the behavior of shape memory alloys (2013)

Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2013.
Experimental study of group thermal comfort model (2014)

Heating, Ventilating and Air Conditioning (HVAC) systems are used to provide adequate thermal comfort to occupants of spaces within buildings. The well-recognized PMV model which represents the `predicted mean vote' (on the thermal sensation scale) of a large population of people exposed to a certain environment is often used by design engineers to determine the size and capacity of HVAC system. In terms of operation, however, due to the differences in personal thermal comfort preferences, it might not be good to determine the room set points based on the general PMV model. In this paper, we extend our previous efforts in modeling the single occupant thermal comfort zone to determining the group occupant thermal comfort zone in an ordinary office environment. Experimental results show that thermal comfort zone for a group of occupants is different from the PMV model.
<i>In Situ</i> Vaccination for the Treatment of Cancer (2016)

Vaccination has had a tremendous impact on human health by harnessing the immune system to prevent and eradicate infectious diseases and this same approach might be used in cancer therapy. Cancer vaccine development has been slowed hindered by the paucity of universal tumor-associated antigens and the difficulty in isolating and preparing individualized vaccines ex vivo. Another approach has been to initiate or stimulate an immune response in situ (at the tumor site) and thus exploit the potentially numerous tumor-associated antigens there. Here, we review the many approaches that have attempted to accomplish effective in situ vaccination, using intratumoral administration of immunomodulators to increase the numbers or activation state of either antigen present cells or T cells within the tumor.
Oil crops of the world: their breeding and utilization (1989)

Oil crops of the world: their breeding and utilization , Oil crops of the world: their breeding and utilization , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Comparative biological and biochemical effects of nogalamycin and its analogs on L1210 leukemia. (1979)

Abstract Nogalamycin, an anthracycline antibiotic, was active against L1210 leukemia in vitro and in vivo . Several new analogs synthesized recently were more active against P388 leukemia, L1210 leukemia, and/or B16 melanoma than was nogalamycin. This study compares the biological and biochemical effects of these compounds on L1210 leukemic cells. Compounds containing the nogalose moiety inhibited RNA synthesis more than DNA synthesis. Nogalamycin (50% inhibitory dose, 0.4 nmol/ml) and dis -nogamycin (50% inhibitory dose, 0.5 nmol/ml) were much more inhibitory towards RNA synthesis than was dis -nogalamycinic acid (50% inhibitory dose, 3.6 nmol/ml). These results paralleled those of cell growth inhibition as well as drug-DNA interaction as measured by circular dichroism and thermal melting of DNA, suggesting that the inhibition of RNA synthesis by these compounds was the result of a major biochemical lesion, probably mediated through the interaction with DNA. With the 7-alkyl analogs, RNA synthesis again was generally inhibited more than DNA synthesis. The dis isomers, i.e. , 7- dis-O -methylnogalarol, 7- dis-O -methylnogarol, and 7- dis-O -ethylnogarol, inhibited RNA synthesis more than did the corresponding con isomers. This phenomenon correlated well with stronger interaction between the dis isomers and DNA. However, the con isomers were generally more inhibitory towards L1210 cell growth. By and large, the biochemical effects observed with the con isomers, particularly 7- con-O -methylnogarol, could not account for their biological activities which appear to be mediated through some mechanism other than their interaction with DNA. The significance of these findings is discussed in terms of drug development.
A development of a permanent magnet assembly for MRI devices using Nd-Fe-B material (1989)

A permanent-magnet assembly for whole-body magnetic resonance imaging (MRI) has been developed, using a high-energy Nd-Fe-B magnet material. The developed assemblies have the following features: (1) by using shimmed pole pieces in addition to the new material, a compact assembly is realized compared with currently used magnets. (2) The signal/noise ratio can be improved about 40% because the field is oriented vertically with respect to the patient. (3) Since the assembly has a four-column configuration, patients feel comfortable during examination. (4) Small leakage flux makes possible installation in a small room. (5) Operating cost is drastically reduced by using a permanent magnet. A typical assembly and its characteristics are shown. It is confirmed that the quality is almost at the same level as that of a mid-field superconducting magnet.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Vehicle positioning method with car-to-car communications in consideration of communication delay (2008)

In this article, the authors propose a car positioning method that can estimate the positions of cars even in areas where the GPS is not available. For the estimation, each car measures the relative distance to a car running in front, communicates the measurements with other cars, and uses the received measurements for estimating its position. In order to estimate the position even if the measurements are received with time-delay, the authors employed the time-delay tolerant Kalman filtering. For sharing the measurements, it is assumed that a car-to-car communication system is used. Then, the measurements sent from farther cars are received with larger time-delay. It follows that the accuracy of the estimates of farther cars become worse. Hence, the proposed method manages only the states of nearby cars to reduce computing effort. The authors simulated the proposed filtering method and found that the proposed method estimates the positions of nearby cars as accurate as the distributed Kalman filtering.
Reduction of Negative Bias and Light Instability of a-IGZO TFTs by Dual-Gate Driving (2014)

Stability under negative-bias-illumination-stress (NBIS) of dual-gate (top- and bottom-gate) amorphous-indium-gallium-zinc-oxide (a-IGZO) thin-film transistors is investigated. It is found that the negative threshold-voltage shift (ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> ) induced by NBIS is much smaller under dual-gate driving (when the two gates are electrically tied together) compared with single-gate driving. For a 20 nm-thick a-IGZO active layer, this is attributed to bulk accumulation, where electrons are accumulated across the entire depth of the active layer, which is responsible for the small negative ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> after NBIS. Due to bulk accumulation, the Fermi level can be easily shifted by dual-gate driving as compared with the conventional single-gate driving, even after NBIS.
Zero-resistance state of two-dimensional electrons in a quantizing magnetic field (1982)

When the Fermi level is pinned in the energy gap between two Landau levels of two-dimensional electrons, the response of electrons in the completely filled levels to an electric field is a dissipation-free Hall current perpendicular to the field. Our low-temperature measurements on GaAs-${\mathrm{Al}}_{x}{\mathrm{Ga}}_{1\ensuremath{-}x}\mathrm{As}$ heterojunctions give an upper limit for the resistance along the current path of ${\ensuremath{\rho}}_{\mathrm{xx}}\ensuremath{\lesssim}5\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}7}$ \ensuremath{\Omega}/\ensuremath{\square} which corresponds to a three-dimensional resistivity of $\ensuremath{\rho}<~5\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}13}$ \ensuremath{\Omega} cm. This resistivity is more than one order of magnitude lower than the resistivity of any nonsuperconducting material.
A Privacy-Preserving Remote Data Integrity Checking Protocol with Data Dynamics and Public Verifiability (2011)

Remote data integrity checking is a crucial technology in cloud computing. Recently, many works focus on providing data dynamics and/or public verifiability to this type of protocols. Existing protocols can support both features with the help of a third-party auditor. In a previous work, Sebé et al. propose a remote data integrity checking protocol that supports data dynamics. In this paper, we adapt Sebé et al.'s protocol to support public verifiability. The proposed protocol supports public verifiability without help of a third-party auditor. In addition, the proposed protocol does not leak any private information to third-party verifiers. Through a formal analysis, we show the correctness and security of the protocol. After that, through theoretical analysis and experimental results, we demonstrate that the proposed protocol has a good performance.
The Nature of Mood: Development of a Conceptual Model with a Focus on Depression (2000)

Abstract The present paper provides a conceptual basis for the examination of mood in sport. The nature of the mood construct is discussed with reference to related constructs. A conceptual model is presented which proposes that certain mood dimensions interact to influence behavior. Depression is proposed to be the most important mood dimension, influencing the intensity of mood responses, the interrelationships among other mood dimensions, and moderating mood and performance relationships for anger and tension. It is hoped that the conceptual model will help guide applied interventions and will act as a catalyst for future research.
Trimethylsilyl reporter groups for <scp>NMR</scp> studies of conformational changes in G protein‐coupled receptors (2019)

Large membrane proteins such as G protein-coupled receptors (GPCRs) are difficult for NMR study due to severe signal overlaps and unfavorable relaxation properties. We used a trimethylsilyl (TMS) group as a reporter group for <sup>1</sup> H NMR study of conformational changes in proteins, utilizing high-intensity <sup>1</sup> H NMR signals near 0 p.p.m. The β<sub>2</sub> -adrenergic receptor was labeled with TMS groups at two cysteines located at the cytoplasmic ends of helices VI and VII. Binding of various ligands led to changes in <sup>1</sup> H NMR signals, which manifested that helix VI is sensitive to G protein-specific activation, whereas helix VII is sensitive to β-arrestin-specific activation. Thus, the TMS group is a useful reporter group in NMR for studying conformational changes in membrane proteins such as GPCRs.
Manganese(III) Acetate: A Versatile Reagent in Organic Chemistry (2007)

Free radical reactions have become increasingly important, as well as a very attractive tool, in organic synthesis within the last two decades, due to their powerful, selective, specific, and mild reaction abilities. Mn(OAc)3 mediated oxidative free radical reactions have been extensively developed in the last twenty years. Numerous regio-, chemo-, and stereoselective synthetic methods have been developed in both inter- and intramolecular reactions, and have detailed the progress of Mn(OAc)3 mediated oxidative free radical reactions since the end of the 19th century. The new literature about the new synthetic methods on Mn(OAc)3 mediated carbon-carbon bond formation and carbon-oxygen bond formation reactions has not been extensively reviewed. The present paper summarizes the recent developments in oxidative free radical reactions mediated by Mn(OAc)3. Mn(OAc)3 mediated reactions of conjugated systems (e.g., alkenes, alkynes, 1,3-alkadienes, l,3-alkadiynes, 1-alken-3-ynes) with β-dicarbonyl compounds, Mn(OAc)3 mediated alkylation, such as the oxidative addition of an aldehyde or ketone to alkenes, Mn(OAc)3 mediated free-radical cyclization of alkenes with active methylene compounds in the presence of oxygen to afford the cyclic peroxides; lactone synthesis by the Mn(OAc)3 mediated oxidative addition of carboxylic acids to alkenes, Mn(OAc)3 mediated cyclization of α- (methylthio)acetamides, enamides, and β-keto carboxamides to afford cyclic products. Mn(OAc)3 oxidative free-radical cyclizations of allylic β-dicarbonyl compounds, for example, the cyclization of allylic β-ketoesters to afford the corresponding γ-lactone. The reaction of alkenes with sodium azide in the presence of acetic acid was investigated to Keywords: Free radical reactions, Lactone synthesis, Cycloperoxidation, Oxidative Cyclization, Carbon-Oxygen Bond Formation
Evaluation of engineering measures on the Danube based on numerical analysis (2017)

Shallow water depths in the southern arm of a widely intact bifurcation zone in the Lower Danube lead to a detour for navigation of ∼110 km on the way to the Black Sea at low discharges. In this study, different conceptual hydraulic engineering measures have been assessed with the goal of increasing the water depths in the southern arm, thereby also considering a minimized impact on fish migration (in particular sturgeons). The effects of the different measures were analysed based on a 3D hydrodynamic numerical model (RSim-3D) and a sediment transport model (iSed). The results show that transverse structures in the northern arm, dredging operations in the southern arm as well as a spur dike at the bifurcation might not lead to the desired success. The most promising alternative considering water depths for navigation and fish migration might be a modification of the river course.
Epigenetic alteration of the NF‐κB‐inducing kinase (<i>NIK</i>) gene is involved in enhanced NIK expression in basal‐like breast cancer (2010)

Basal-like breast cancers are triple-negative (estrogen receptor negative, progesterone receptor negative, erythroblastic leukemia viral oncogene homolog 2 (ERBB2) negative) tumors with an aggressive clinical behavior that lacks effective molecular targets for therapy. We reported previously that the basal-like subtype cell lines display high constitutive nuclear factor (NF)-κB activation, whose inhibition in the basal-like subtypes suppressed their proliferation. Moreover, NF-κB-inducing kinase (NIK) is involved in the constitutive NF-κB activation. Here, we report that enhanced NIK expression, which is exclusively observed in the basal-like subtype rather than the luminal-like subtype or non-tumorigenic mammary epithelial cells, is caused by epigenetic alteration of the NIK gene. The stability of NIK mRNA and transcriptional activity driven by the NIK promoter are similar in the basal-like and luminal-like subtypes. However, histone H3 acetylation levels were up-regulated in the basal-like subtype. Furthermore, treatment of the luminal-like subtype with a histone deacetylase inhibitor, valproic acid, significantly increased NIK expression. Although DNA methylation of the NIK locus was not detected, NIK expression also increased when the luminal-like subtype was treated with 5-azacytidine, which inhibits histone H3-Lys-9 dimethylation in addition to DNA methylation. Taken together, these results suggest that the closed chromatin structure mediated by histone H3 methylation and deacetylation suppresses NIK expression in the luminal-like subtype, whereas disruption of these suppression mechanisms leads to enhanced NIK expression and the constitutive NF-κB activation in the basal-like subtype. Thus, NIK and genes induced by the NIK-mediated constitutive NF-κB activation could be therapeutic targets of basal-like breast cancer.
Letters to the Editor: 1 (2002)

To the Editor: We read the article by Gentsch et al. (1) describing the influence of fenfluramine and paroxetine on the epileptic activity of rat entorhinal cortex with great interest. After the publication of Aicardi and Gastaut (2), we used fenfluramine in a group of 11 children with intractable epilepsy resistant to other anti-epileptic drugs available at that time (3). We now report our further experience with fenfluramine in 22 patients. All patients had severe tonic–clonic seizures before the add-on therapy. Since 1988, fenfluramine has been used as add-on therapy in patients with self-induced seizures (22 of 22). Most of the patients were photosensitive at the time of the diagnosis (13 of 22). So far, 22 patients (11 girls, 11 boys) have been treated (Table 1). In six patients (group A), fenfluramine did not improve seizure control, and the drug was discontinued. Ten patients (group B) continued to use fenfluramine because of a 90% improvement rate. Only sporadic, minor ocular seizures still occur. Six patients (group C) continued to use fenfluramine because seizures were completely controlled. In groups B and C, side effects were limited to transient loss of appetite (one of 16 children) and fatigue after work or physical exercise (one of 16 patients). One of the six patients with complete seizure control (group C), who was taking sodium-valproate and fenfluramine, was seizure free for 10 years. EEGs did not reveal any epileptiform activity at age 24 years. Stopping fenfluramine resulted in a generalized tonic–clonic seizure, during which she broke a leg. Restarting fenfluramine, again resulted in complete seizure control. Apart of this single seizure, the six patients (in group C) had seizure-free periods ranging from 1 to 12 years. In 16 patients (group B and C) still taking fenfluramine, the duration of add-on therapy varied between 1 and 12 years, and the dose of fenfluramine varied between 0.25 and 1 mg/kg/day. We conclude that in young patients with intractable epilepsy and self-induced seizures, fenfluramine should be considered as add-on therapy.
Necrosectomy with an Ultrasonic Dissector in the Treatment of Necrotizing Pancreatitis (2006)

Necrosectomy with an ultrasonic dissector and gentamicin-containing sponge inserted into the post-necrotic bed are effective and well tolerated in the open packing treatment of NP.
Synthesis of (-)-(6R,10R)-matsuone. Assignment of relative stereochemistry to a pheromone of Matsucoccus pine bast scales (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (-)-(6R,10R)-matsuone. Assignment of relative stereochemistry to a pheromone of Matsucoccus pine bast scalesCharles L. Cywin, Francis X. Webster, and James KallmertenCite this: J. Org. Chem. 1991, 56, 9, 2953–2955Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/jo00009a004https://doi.org/10.1021/jo00009a004research-articleACS PublicationsRequest reuse permissionsArticle Views370Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Hardware-in-the-loop control of additive manufacturing processes using temperature feedback (2016)

Laser-based additive manufacturing is a technology for the production of freeform metallic parts. In order to produce parts with high quality, it is important for the manufacturing processes to be controllable with a high degree of precision. Current additive manufacturing systems attempt to reach this goal by carefully tuning the operational parameters, often in combination with a feedback control system. These systems are based on low order, empirical models of the process, which may limit the performance that can be achieved. This paper introduces a control system based on a high order physical heat conduction model of the melt pool dynamics. The control system serves as a framework which can be applied to many laser material processes in which high precision is required such as laser cladding and selective laser melting. The controller is able to regulate the melt pool size by modulating the laser power using a number of surface temperature measurements as the feedback signal. A hardware-in-the-loop (HIL) system was built to enable safe and cost-effective testing of the controller hardware in different simulation environments. The HIL setup includes a real-time image processing module for extracting the required temperature information from hyperspectral data generated by detailed numerical simulations of the melt pool dynamics. Hyperspectral measurements are performed on a laser cladding system to validate the simulation results.
Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production (2002)

Under steady-state conditions, internalization of self-antigens embodied in apoptotic cells by dendritic cells (DCs) resident in peripheral tissue followed by DC migration and presentation of self-peptides to T cells in secondary lymphoid organs are key steps for induction and maintenance of peripheral T-cell tolerance. We show here that, besides this traffic of apoptotic cells mediated by peripheral tissue-resident DCs, splenic marginal zone DCs rapidly ingest circulating apoptotic leukocytes, process apoptotic cell-derived peptides into major histocompatibility complex class II (MHC-II) molecules, and acquire CD8alpha during their mobilization to T-cell areas of splenic follicles. Because apoptotic cells activate complement and some complement factors are opsonins for phagocytosis and play roles in the maintenance of peripheral tolerance, we investigated the role of complement receptors (CRs) in relation to phagocytosis of apoptotic cells by DCs. Apoptotic cell uptake by marginal zone DCs was mediated in part via CR3 (CD11b/CD18) and, to a lesser extent, CR4 (CD11c/CD18) and was reduced significantly in vivo in hypocomplementemic animals. Following phagocytosis of apoptotic cells, DCs exhibited decreased levels of mRNA and secretion of the proinflammatory cytokines interleukin 1alpha (IL-1alpha), IL-1beta, IL-6, IL-12p70, and tumor necrosis factor alpha (TNF-alpha), without effect on the anti-inflammatory mediator transforming growth factor beta1 (TGF-beta1). This selective inhibitory effect was at least partially mediated through C3bi-CD11b/CD18 interaction. Characterization of apoptotic cell/DC interaction and its outcome provides insight into the mechanisms by which apoptotic cells affect DC function without disrupting peripheral tolerance.