gebhart/patrepeval huggingface dataset:
CMP-SiL: Confidential Multi Party Software-in-the-Loop Simulation Frameworks (2023)

Increasing complexity of systems and software in the automotive industry, coupled with distributed development environments has intensified adoption of Software in the Loop (SIL) systems, i.e. setup where traditional hardware components are designed and tested in pure virtual PC/IT environment consisting of virtualized hardware and networks. Cloud-based SiL simulation systems involving multiple contributors and orchestrators create huge risks for organizations due to potential for leakage of confidential model-IP to adversaries within the distributed infrastructure. This can create a bottleneck for wide-scale adoption of SiL-systems. We propose a data-flow architecture using trusted-computing technologies (e.g. Intel-SGX) to protect models and IP in cloud-based SiL environments. We illustrate that these protections can be designed to be compatible with existing SiL tools and workflows with minimal modifications. Further, we highlight the need for future standardization efforts of such security architectures in the SiL domain.
Design and Optimization of an Innovative Solid Oxide Fuel Cell–Gas Turbine Hybrid Cycle for Small Scale Distributed Generation (2014)

Abstract Distributed power generation and cogeneration is an attractive way toward a more rational conversion of fuel and biofuel. The fuel cell‐gas turbine hybrid cycles are emerging as the most promising candidates to achieve distributed generation with comparable or higher efficiency than large‐scale power plants. The present contribution is devoted to the design and optimization of an innovative solid oxide fuel cell–gas turbine hybrid cycle for distributed generation at small power scale, typical of residential building applications. A 5 kW planar SOFC module, operating at atmospheric pressure, is integrated with a micro gas turbine unit, including two radial turbines and one radial compressor, based on an inverted Brayton cycle. A thermodynamic optimization approach, coupled with system energy integration, is applied to evaluate several design options. The optimization results indicate the existence of optimal designs achieving exergy efficiency higher than 65%. Sensitivity analyses on the more influential parameters are carried out. The heat exchanger network design is performed for an optimal configuration and a complete system layout is proposed. An example of hybrid system integration in a common residential building is discussed.
Nitro-oleic acid and epoxyoleic acid are not altered in obesity and Type 2 diabetes: reply (2014)

We appreciate the interest in our recent study of the in vivo signalling actions of electrophilic fatty acid nitroalkenes,1 including the commentary from Tsikas et al. This study is based on a high-fat diet (HFD)-induced obesity murine model that displays the canonical features of metabolic syndrome, including glucose tolerance, vascular dysfunction, increased inflammation, adipokine dysfunction, and most notably development of pulmonary hypertension. We tested the pharmacological actions of synthetic 10-nitro-octadec-9-enoic acid (OA-NO2) and reported potent protective actions of OA-NO2 in this murine model of HFD-induced obesity and pulmonary hypertension. First and foremost, we stress that under no circumstance did we state or imply the existence of any link between obesity and decreased OA-NO2 biosynthesis. This is an incorrect and misleading interpretation of the data presented in our manuscript.

The …
Volume holographic imaging (2003)

We overview the properties of volume holographic imaging properties and design framework for depth-selective and hyperspectral imaging. The Bragg selectivity and degeneracy properties of volume holograms are used for optical slicing and space-selective dispersion.
Modeling of Oxidized PTH (oxPTH) and Non-oxidized PTH (n-oxPTH) Receptor Binding and Relationship of Oxidized to Non-Oxidized PTH in Children with Chronic Renal Failure, Adult Patients on Hemodialysis and Kidney Transplant Recipients (2013)

A huge proportion of circulating PTH measured by current state-of-the-art assay systems is oxidized and thus not biologically active. The relationship between oxPTH and n-oxPTH of individual patients varied substantially. Non-oxidized PTH concentrations are 1.5 - 2.25 fold higher in patients with renal failure as compared to health controls. Measurements of n-oxPTH may reflect the hormone status more precise. The iPTH measures describes most likely oxidative stress in patients with renal failure rather than the PTH hormone status. This, however, needs to be demonstrated in further clinical studies. © 2013 S. Karger AG, Basel.
Biocatalytically Initiated Precipitation Atom Transfer Radical Polymerization (ATRP) as a Quantitative Method for Hemoglobin Detection in Biological Fluids (2019)

The hemoglobin content of blood is an important health indicator, and the presence of microscopic amounts of hemoglobin in places where it normally does not occur, e.g. in blood plasma or in urine, is a sign of diseases such as hemolytic anemia or urinary tract infections. Thus, methods to detect and quantify hemoglobin are important for clinical laboratories, blood banks, and for point-of-care diagnostics. The precipitation polymerization of <i>N</i>-isopropylacrylamide by hemoglobin-catalyzed atom transfer radical polymerization (ATRP) is used as an assay for hemoglobin quantification relying on the formation of turbidity as a simple optical read-out. Dose-response curves for pure hemoglobin and for hemoglobin in blood plasma, in urine, in erythrocytes, and in full blood are obtained. Turbidity formation increases with the concentration of hemoglobin. Concentrations of hemoglobin as low as 6.45 × 10<sup>-3</sup> mg mL<sup>-1</sup> in solution, 4.88 × 10<sup>-1</sup> mg mL<sup>-1</sup> in plasma, and 1.65 × 10<sup>-1</sup> mg mL<sup>-1</sup> in urine could be detected, which is below the clinically relevant concentrations in the respective body fluids. Total hemoglobin in full blood is also accurately determined. The reaction can be regarded as a polymerization-based signal amplification for the sensing of hemoglobin, as the analyte catalyzes the formation of radicals which add many monomer units into detectable polymer chains. While most established hemoglobin tests involve the use of highly toxic reagents such as potassium cyanide, the polymerization-based test uses simple and stable organic reagents. Thus, it is an environmentally friendlier alternative to established chemical assays for hemoglobin.
Identification of QTLs for Botrytis cinerea Resistance in S. Habrochaites LYC4 (2006)

BOTRYTIS cinerea Pers:Fr (teleomorph: Botryotina fuckeliana (de Bary) Whetzel) is a necrotrophic pathogenic fungus with an exceptionally wide host range of at least 235 species. Modern hybrid tomato (Solanum lycopersicum) cultivars are susceptible to B. cinerea although there are cultivars with some quantitative resistance. In a screening Solanum habrochaites LYC4 showed a good level of resistance. To study the genetics behind this resistance, an F2 population (n=174) of the cross between a susceptible genotype S. lycopersicum cv. Moneymaker and S. habrochaites LYC4 was developed. Initially, two QTLs for resistance to B. cinerea were identified (QTL1 and QTL2). During the confirmation of these two QTLs in segregating BC2S1 families, a third QTL (QTL3) was identified from which the effect could only be observed in absence of QTL2. A set of QTL specific CAPS makers was developed as a tool for marker assisted selection (MAS). Using this set of markers, one BC2S1 line was selected which was homozygous for both QTL 1 and QTL3. BC2S2 offspring of this line was tested for resistance to B. cinerea in a greenhouse trail. In the selected BC2S2 offspring only 15% of the infections were successfully established (disease incidence). This is significantly less than the susceptible control S. lycopersicum (disease incidence 70%); a commercial cultivar known as fairly resistant still had a disease incidence of 50%. This result shows that the QTLs from S. habrochaites LYC4 offer good perspectives for breeding B. cinerea resistant tomato cultivars.
The alpha-L-(1----2)-trirhamnopyranoside epitope on the group-specific polysaccharide of group B streptococci (1991)

A number of epitope specificities associated with the group antigen (group B polysaccharide) of group B streptococci have been identified in a polyclonal antiserum induced in rabbits by a nonencapsulated variant strain of group B streptococci. This was achieved by using a series of oligosaccharide inhibitors, obtained by both synthetic and degradative procedures, to inhibit the binding of the group B polysaccharide to the polyclonal antiserum. While the dominant epitope expressed in the antiserum was alpha-L-Rhap(1----2)alpha-L-Rhap(1----2)alpha-L-Rhap, specificities associated with alpha-L-Rhap and alpha-L-Rhap(1----3)alpha-D-Galp(1----3)beta-D-Glcp-NAc(1----4)alp ha-L-Rhap were also identified. The dominant expression of the former epitope is consistent with its terminal location on the group antigen and also with highly branched multiantennary structure of this antigen. Antibodies specific for the alpha-L-trirhamnopyranoside epitope were purified by affinity chromatography, using the synthetic trisaccharide glucitol as the hapten. Oligosaccharide inhibition studies indicate that the specificity of these antibodies is identical to that of a murine monoclonal antibody induced by the same nonencapsulated strain of group B streptococci.
Polarimetric SAR image signatures of the ocean and Gulf Stream features (1993)

Polarimetric signatures and related polarimetric properties of microwave ocean backscatter are analyzed for both the ambient ocean and for ocean features such as those associated with the Gulf Stream. Interpretation of the polarimetric signatures for the ocean surface is accomplished using a tilted-Bragg theoretical model. This model is used to calculate the EM fields, to second order, which is necessary to compute the full Stokes matrix and, ultimately, the polarimetric signature. The polarimetric studies lead to a technique for potentially improving the visibility of all azimuthally traveling waves in real-aperture radar (RAR) images and very long waves in synthetic-aperture radar (SAR) images. This technique utilizes linear polarization signatures to maximize the instrument sensitivity to azimuthally traveling waves. Wave tilts create a modulation of the cell polarization orientation which, in turn, modulates the backscatter. Critical to the success of this technique is that the ocean polarimetric signatures be sharply peaked (i.e., returns be highly polarized). The polarimetric contribution to the overall modulation transfer function is evaluated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Investigation of Technical Problems in Gallium Arsenide (1974)

Abstract : A broad area of technolgical problems of GaAs is covered in this progress report. The goal is to make contributions that will improve the current technology of microwave devices. The devices considered here are the Schottky barrier FET (MESFET) and the IMPATT diode. The work reported here covers problems of growth and characterization of very thin high-conductivity epitaxial films and high-resistivity epitaxial films; some aspects of processing of MESFET devices; study of the RF performance of IMPATT diodes and its relationship with the material parameters; problems of growth and characterization of semi-insulating GaAs; use of proton bombardment to convert conductive layers into high-resistivity layers, and, finally, study of n-type doping of GaAs by ion implantation with particular emphasis on the annealing problems. (Modified author abstract)
A Formylated Hexapeptide Ligand Mimics the Ability of Wnt-5a to Impair Migration of Human Breast Epithelial Cells (2005)

Loss of Wnt-5a protein expression is associated with shorter recurrence-free survival in breast carcinoma patients and increased motility in mammary cell lines. Based on sequence analysis of Wnt-5a, we identified 14 peptide fragments and investigated their ability to mimic the effects of Wnt-5a on mammary cell adhesion and migration. Two of these peptides significantly increased adhesion and impaired migration in the non-tumorigenic HB2 breast epithelial cell line and in the MDA-MB-468 breast cancer cell line, both of which show little endogenous expression of the Wnt-5a protein. We removed two amino acids at a time from the N terminus of the shorter of these two peptides to identify the shortest peptide that still inhibited migration. The influence on tumor cell adhesion was gradually lost and was no longer detectable when only six amino acids remained. However, formylation of the N-terminal methionine of this hexapeptide restored its effect on adhesion and reduced tumor cell motility via a Frizzled-5 receptor-dependent mechanism, even at a low pH such as encountered in breast tumor tissue. This formylated hexapeptide ligand induced a rapid cytosolic calcium signal, whereas it did not affect the cellular levels of unphosphorylated beta-catenin or active JNK. The novel formyl-Met-Asp-Gly-Cys-Glu-Leu peptide ligand is not only a valuable experimental tool but has also a potential role in antimetastatic treatment of the 50% of human breast cancer patients that have reduced endogenous Wnt-5a protein expression.
Frequency Selective Surface Effects on a Coplanar Waveguide Feedline in Fabry–Perot Cavity Antenna Systems (2018)

Planar array designs and three-dimensional (3-D) high-density integration can degrade antenna performance due to feedline interference and coupling. To minimize this effect, a single source element with feedline is combined with a frequency selective surface (FSS) to form a Fabry-Perot Cavity antenna (FPCA) system. The FSS focusing of the antenna radiation also focuses the feedline energy, which can degrade the overall FPCA system radiation pattern. This letter presents a technique to reduce undesired feedline radiation enhanced by an FSS. Orientation-sensitive FSS designs are studied to minimize feedline electric field concentration above the FSS. Feedline radiation focusing above the FSS can be minimized from 4.95 to -2.4 dBi in the far field.
Influence of novel KGFR tyrosine kinase inhibitors on KGF-mediated proliferation of breast cancer. (2010)

The compounds examined appear to be selective KGFR inhibitors which inhibit KGF-mediated activity and reduce the expression of KGFR on cancer cells. These results may lead to the development of a novel class of anticancer agents for the prevention of metastatic cancer progression.
Cyclic Poly(phthalaldehyde): Thermoforming a Bulk Transient Material (2017)

Cyclic poly(phthalaldehyde) (cPPA) is a metastable and stimuli responsive polymer that undergoes rapid solid state depolymerization and has been utilized as a packaging and encapsulating material for transient applications. However, the early onset thermal depolymerization of cPPA severely hinders the fabrication and processing of plastic parts. Herein, the thermally triggered depolymerization of cPPA was investigated and tailored to enable thermal processing and molding of cPPA at moderate temperatures below the thermal depolymerization temperature. Stabilization of cPPA at elevated temperature was accomplished by removal of the latent Lewis acid catalyst BF<sub>3</sub> and by addition of radical inhibitors and a Lewis base. Addition of a plasticizer to the stabilized cPPA enabled the fabrication of a monolithic solid polymer via hot press molding. Importantly, it is shown that the thermally processed cPPA retains its stimuli responsive depolymerization capability and will enable future work in the fabrication of bulk plastic parts that depolymerize and disintegrate on demand.
Error diffusion algorithm with output position constraints for homogeneous highlight and shadow dot distribution (2000)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Glass‐Bead‐Based Parallel Detection of DNA Using Composite Raman Labels (2006)

Gold nanoparticles are co-functionalized with multiple types of Raman-dye-labeled oligonucleotides (see picture) to prepare composite Raman labels for DNA targets that are used in a glass-microbead-based multiplexed DNA detection system in conjunction with surface-enhanced Raman scattering (SERS) spectroscopy. The narrow bands of the Raman spectra of the dye-labeled nanoparticles allow for greater degrees of multiplexing when compared to the broad absorption and emission bands of molecular fluorophores. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2296/2006/z500322_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A New Strategy for Immunotherapy of Cancer (2009)

The best way to prevent and remove infections is through the natural 'sterilising' action of the immune response that combines elements of both innate and adaptive immunity to ward off foreign pathogens without medical intervention. The immune system 'remembers' the cleared foreign antigens to speed up its response to re-infection. The immune system in most cancer patients can still completely destroy viruses and bacteria. The ferocity and specificity of this response can be witnessed in the way an inadequately suppressed immune system can completely destroy a large transplanted organ, while sparing one’s own (self) tissues. This destructive effect would be beneficial for cancer therapy if it could be directed at tumours. The field of immunotherapy seeks methods to harness, direct and control this immunity especially against cancer. Therapeutic cancer vaccines are a form of immunotherapy designed to educate the immune system of patients with existing cancers to recognise their tumour cells as foreign rather than self. If successful, an immune response could theoretically stimulate immune cells to destroy large tumours, and
A membrane protein encoded by Epstein-Barr virus in latent growth-transforming infection. (1984)

The nucleotide sequence of an Epstein-Barr virus gene expressed in latently infected growth-transformed cells is known to include a long open reading frame containing a 33-base-pair repeat element. A bacterial fusion protein constructed from a portion of the reading frame and Escherichia coli beta-galactosidase was used to produce sera in rabbits against the previously unidentified gene product. The viral protein detected with these sera in latently infected cells varies in size with the number of copies of the DNA repeat element. Translation of the RNA in vitro yields a protein of similar size. As expected from its primary sequence, the protein is a membrane protein. Immunofluorescence studies with the rabbit antisera suggest that the protein is in the plasma membrane. Thus, this protein could be the lymphocyte-determined membrane antigen (LYDMA) responsible for the generation of T-cell immunity to latently infected cells.
A Persona-based Multi-turn Conversation Model in an Adversarial Learning\n Framework (2019)

In this paper, we extend the persona-based sequence-to-sequence (Seq2Seq)\nneural network conversation model to multi-turn dialogue by modifying the\nstate-of-the-art hredGAN architecture. To achieve this, we introduce an\nadditional input modality into the encoder and decoder of hredGAN to capture\nother attributes such as speaker identity, location, sub-topics, and other\nexternal attributes that might be available from the corpus of human-to-human\ninteractions. The resulting persona hredGAN ($phredGAN$) shows better\nperformance than both the existing persona-based Seq2Seq and hredGAN models\nwhen those external attributes are available in a multi-turn dialogue corpus.\nThis superiority is demonstrated on TV drama series with character consistency\n(such as Big Bang Theory and Friends) and customer service interaction datasets\nsuch as Ubuntu dialogue corpus in terms of perplexity, BLEU, ROUGE, and\nDistinct n-gram scores.\n
Double-Blind Consent-Driven Data Sharing on Blockchain (2018)

Blockchains are designed for trustworthy and transparent execution of transactions involving multiple parties. An important class of applications requires data to be shared selectively among mutually anonymous transacting peers while retaining the tamper-resistant evidentiary and validation features of a blockchain. KYC validations of corporate customers by banks is one example, where both banks and customers benefit from sharing process and data on a blockchain network. However, sharing of confidential KYC data must be authorized by customers, and a bank-customer relationship must be kept secret from other banks in the network. In this paper, we describe the design and implementation of a smart contract for consent-driven and double-blind data sharing on the Hyperledger Fabric blockchain platform. We show how a KYC application was built around this model to address the needs of the banks while meeting regulatory requirements.
Combining lexicon-based and learning-based methods for twitter sentiment analysis (2011)

With the booming of microblogs on the Web, people have begun to express their opinions on a wide variety of topics on Twitter and other similar services. Sentiment analysis on entities (e.g., products, organizations, people, etc.) in tweets (posts on Twitter) thus becomes a rapid and effective way of gauging public opinion for business marketing or social studies. However, Twitter's unique characteristics give rise to new problems for current sentiment analysis methods, which originally focused on large opinionated corpora such as product reviews. In this paper, we propose a new entity-level sentiment analysis method for Twitter. The method first adopts a lexiconbased approach to perform entity-level sentiment analysis. This method can give high precision, but low recall. To improve recall, additional tweets that are likely to be opinionated are identified automatically by exploiting the information in the result of the lexicon-based method. A classifier is then trained to assign polarities to the entities in the newly identified tweets. Instead of being labeled manually, the training examples are given by the lexicon-based approach. Experimental results show that the proposed method dramatically improves the recall and the F-score, and outperforms the state-of-the-art baselines. External Posting Date: June 21, 2011 [Fulltext] Approved for External Publication Internal Posting Date: June 21, 2011 [Fulltext]  Copyright 2011 Hewlett-Packard Development Company, L.P. Combining Lexicon-based and Learning-based Methods for Twitter Sentiment Analysis Lei Zhang, Riddhiman Ghosh, Mohamed Dekhil, Meichun Hsu, Bing Liu Hewlett-Packard Laboratories University of Illinois at Chicago 1501 Page Mill Rd., Palo Alto, CA 851 S. Morgan St., Chicago, IL {riddhiman.ghosh, mohamed.dekhil, {lzhang3, liub}@cs.uic.edu meichun.hsu}@hp.com
Circulating Tumor Cell Enumeration with a Combination of Epithelial Cell Adhesion Molecule– and Cell-Surface Vimentin–Based Methods for Monitoring Breast Cancer Therapeutic Response (2014)

The sum of CTC counts from the CellSearch and CSV methods appears to provide new insights for assessment of therapeutic response and thus provides a new approach to personalized medicine in breast cancer patients.