gebhart/patrepeval huggingface dataset:
Human Histologic Verification of Gingival Uniformity Pinkening via Selective Radiofrequency Ablative Deepithelization (2023)

Various gingival depigmentation techniques have been introduced to realize esthetic gingival color enhancement. Unfortunately, many of these procedures have nonesthetic outcomes, have the potential to damage the gingiva and connective tissues, subject the patient to postoperative pain, and do not offer long-term efficacy. The proper combined application of a 4.0-MHz radiofrequency and specialized electrode brush may result in the selective and complete removal of melanocytes from the gingival epithelium down to and including the basal layer, with minimal to no effect on the connective tissue. This article presents a case report and histopathologic examination to demonstrate the effectiveness and safety of this technique for achieving uniform pink gingival appearance.
Preclinical development of a potent VEGFR-2 antagonist based on a novel protein scaffold (AdNectin) (2005)

3037 Shortcomings of traditional antibody technology have prompted the development of antagonists using addressable fibronectin proteins (AdNectins). These novel antagonists are based on the 10th Type III domain of human fibronectin (∼10 kDa). The benefits of AdNectins include the ability to rapidly identify high affinity binders with tailored binding kinetics, as well as the ability to produce these proteins by economic E. coli -based production methods. Using this technology an AdNectin antagonist to VEGFR-2 was developed. VEGFR-2 was chosen as a target because of its well validated role in angiogenesis. Activation of VEGFR-2 stimulates multiple endothelial cell functions (e.g., migration, proliferation, and survival) and induces angiogenesis and blood vessel permeability. The anti-VEGFR-2 AdNectin, CT322, is a 10 kDa monomeric protein that is highly stable at 37°C. CT322 binds human and mouse VEGFR-2-Fc with affinities of 0.2 nM and 4 nM, respectively. Low levels of CT322 (130 pM) were sufficient to completely block VEGF-A induced VEGFR-2 phosphorylation and ERK1/2 activation in human primary endothelial cells. CT322 efficiently blocked VEGF-induced human primary endothelial cell proliferation, migration and tube formation. Moreover, CT322 blocked both VEGF-C and VEGF-D induced activation of VEGFR-2. Together these data indicate that CT322 is a potent antagonist of VEGFR-2 in endothelial cells. The pharmacokinetic profile for CT322 was determined in rats using 125 I-labelled CT322. CT322 was rapidly cleared (70 ml/hr/kg) via the kidneys. Addition of a single, branched 40 kDa polyethylene glycol (PEG40) reduced the clearance rate to 5.2 ml/hr/kg leading to 10 fold increase in bioavailability as calculated by AUC of 14.6 and 193 hr*μg/ml for CT322 and CT322-PEG40, respectively. No accumulation of CT322-PEG40 in normal tissues was observed. A classical Miles assay for microvessel permeability was used to determine whether CT322 can also block VEGFR-2 in vivo . Mice were pre-treated by a single i.p. injection of CT322-PEG40 4 hours prior to the experiment. CT322-PEG40 inhibited VEGF-induced vessel permeability at 5 mg/kg dose indicating an effective blockage of VEGFR-2 activity in vivo . The effect of CT322-PEG40 in various mouse and human xenografts tumor models was subsequently evaluated. CT322-PEG40 significantly inhibited tumor growth in the various models at dose range of 10 - 40 mg/kg suggesting a potential therapeutic use. In summary: We have developed a receptor antagonist based on a novel alternative protein scaffold that can be produced in E. coli and has high target specificity and affinity as well as favorable biophysical properties. Although CT322 is intended to block human VEGFR-2 (KDR), it was designed to also be effective in blocking murine VEGFR-2 (Flk1). Consequently, CT322 has been shown to be very effective in inhibiting tumor growth in multiple pre-clinical models.
Review of pharmacological therapy for tinnitus. (2006)

This article provides a review of studies investigating the pharmacological treatment of tinnitus. Tinnitus continues to be a significant and costly health problem without a uniformly accepted treatment. A wide variety of studies exploring prescription, supplement, and vitamin therapies are assessed for efficacy of treatment and for establishing consistencies in symptom definition, assessment, and outcome measures. This review reveals no compelling evidence suggesting the efficacy of any pharmacological agent in the treatment of tinnitus. Analysis of prior investigations provides insight to appropriate methods for future work, which are outlined.
Effect of a cigarette smoke extract on the metabolism of the proinflammatory autacoid, platelet-activating factor. (1992)

Cigarette smoking is associated with an increased incidence of a number of diseases. Minimal information is available at the molecular level concerning the mechanism of action of cigarette smoke. Platelet-activating factor (PAF) is one of the most potent proinflammatory agents described. PAF concentration may be regulated by the degradation of PAF as catalyzed by the plasma enzyme, PAF acetylhydrolase (PAF-AH). This enzyme is associated with the lipoprotein fraction. The exposure of low density lipoprotein to a cigarette smoke extract (CSE) has been shown to alter the charge of low density lipoprotein and its uptake by macrophages. The activity of PAF-AH in the lipoprotein fraction has been assayed after exposure to CSE. The activity of PAF-AH was inhibited by the CSE in a dose-dependent manner. The inhibition of PAF-AH by the CSE was not altered by superoxide dismutase or catalase addition. Sulfhydryl compounds prevented and reversed the inhibition of PAF-AH caused by CSE. The inhibitor present in CSE was not nicotine, its major metabolic product, (-)-cotinine, or several compounds known to be present in the extract. The charge alteration reaction(s) and PAF-AH inhibition appear to be localized at different sites of the lipoprotein molecule. The observed inhibition may account for the increase in the plasma PAF concentration that is known to occur in smokers. The increase of PAF may contribute to the increased incidence of cardiovascular and lung diseases known to be present in smokers.
Analysis of advanced circuits for SET measurement (2015)

Single Event Transients (SETs) are a growing concern in advanced integrated circuits yet techniques to accurately characterize the cross-section and pulse width of SETs are less mature than those for measuring SEUs. We present four circuits for measuring SETs, an analysis of their capabilities and the subtleties in their implementation. Post-layout circuit simulation results are presented for a test-chip implemented in 28 nm FSDOI technology and integrating these detectors.
Switched-capacitor filters: precise, compact, inexpensive (1988)

Switched-capacitor filters-silicon ICs that combine features of analog and digital filters-are penetrating markets far beyond the telephone networks for which they were first developed. They are now found in audio equipment, speech analyzers and recognizers, test instruments, and electronic musical instruments. Their precision, compactness, and low cost make them preferable to discrete and hybrid filters, as well as to digital filters. Design engineers needing quantities of inexpensive, precise, self-contained filters make switched-capacitor filters (SCFs) their first choice. The author discusses the construction, operation, building blocks, and problems of SCFs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Deep-Rough Mutant of <i>Campylobacter jejuni</i> 81-176 Is Noninvasive for Intestinal Epithelial Cells (2004)

A waaF mutant of Campylobacter jejuni 81-176 showed decreased invasion of INT407 cells in vitro and increased sensitivity to some antibiotics compared to what was seen with the wild-type strain.
Effects of Bottom Electrode Topography in AlN Nano Plate Resonators on Quality Factor (2018)

This paper reports on the experimental study of the effects of bottom electrode topography in AlN nano plate resonators (NPRs) on quality factor. We show that efficient piezoelectric transduction of a high frequency (~744 MHz) lateral-extensional mode of vibration and a quality factor as high as ~1300 can be achieved when a 70 nm thick platinum layer is employed as the interdigitated electrode underneath of a 200 nm thick AlN nano plate. Such a high value of quality factor is comparable to that achieved in reference devices with inversed electrode design (employing an unpatterned floating plate as the bottom electrode). The smoothly-transitioned topography of the bottom electrode, more specifically, the tapered edge of the patterned interdigitated electrode is identified as the key contributing factor to the achievement of high quality factors.
Hydrogen abstraction from a diamond surface. Ab initio quantum chemical study with constrained isobutane as a model (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogen abstraction from a diamond surface. Ab initio quantum chemical study with constrained isobutane as a modelMichael Page and Donald W. BrennerCite this: J. Am. Chem. Soc. 1991, 113, 9, 3270–3274Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ja00009a008https://doi.org/10.1021/ja00009a008research-articleACS PublicationsRequest reuse permissionsArticle Views120Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expanded Climate Risk Disclosure Requirements by the Security and Exchange Commission (2021)

Due principally to the growing awareness of the impacts of climate change and related investor diligence regarding potential financial risks, the regulatory compliance and reporting framework surrounding climate change risk disclosure is expanding.
Source Cell-Phone Identification in the Presence of Additive Noise from CQT Domain (2018)

With the widespread availability of cell-phone recording devices, source cell-phone identification has become a hot topic in multimedia forensics. At present, the research on the source cell-phone identification in clean conditions has achieved good results, but that in noisy environments is not ideal. This paper proposes a novel source cell-phone identification system suitable for both clean and noisy environments using spectral distribution features of constant Q transform (CQT) domain and multi-scene training method. Based on the analysis, it is found that the identification difficulty lies in different models of cell-phones of the same brand, and their tiny differences are mainly in the middle and low frequency bands. Therefore, this paper extracts spectral distribution features from the CQT domain, which has a higher frequency resolution in the mid-low frequency. To evaluate the effectiveness of the proposed feature, four classification techniques of Support Vector Machine (SVM), Random Forest (RF), Convolutional Neural Network (CNN) and Recurrent Neuron Network-Long Short-Term Memory Neural Network (RNN-BLSTM) are used to identify the source recording device. Experimental results show that the features proposed in this paper have superior performance. Compared with Mel frequency cepstral coefficient (MFCC) and linear frequency cepstral coefficient (LFCC), it enhances the accuracy of cell-phones within the same brand, whether the speech to be tested comprises clean speech files or noisy speech files. In addition, the CNN classification effect is outstanding. In terms of models, the model is established by the multi-scene training method, which improves the distinguishing ability of the model in the noisy environment than single-scenario training method. The average accuracy rate in CNN for clean speech files on the CKC speech database (CKC-SD) and TIMIT Recaptured Database (TIMIT-RD) databases increased from 95.47% and 97.89% to 97.08% and 99.29%, respectively. For noisy speech files with seen noisy types and unseen noisy types, the performance was greatly improved, and most of the recognition rates exceeded 90%. Therefore, the source identification system in this paper is robust to noise.
Soiling test methods and their use in predicting performance of photovoltaic modules in soiling environments (2012)

Photovoltaic modules installed in most outdoor locations accumulate soil which reduces power output. To better understand and model this problem, and to evaluate surface treatments that might help to alleviate the problem, we developed soiling test methods to mimic specific environments. Many factors that affect accurate measurements and the extrapolation of laboratory measurements to outdoor performance are discussed. Examples of various materials, including some that have anti-soiling properties, are included to illustrate the importance of accurate testing and the care that must be exercised when using laboratory data to predict real-world performance.
Multiple Bit Upset Tolerant Memory Using a Selective Cycle Avoidance Based SEC-DED-DAEC Code (2007)

Conventional error correcting code (ECC) schemes used in memories and caches cannot correct double bit errors caused by a single event upset (SEU). As memory density increases, multiple bit upsets in nearby cells become more frequent. A methodology is proposed here for deriving an error correcting code through heuristic search that can detect and correct the most likely double bit errors in a memory while minimizing the miscorrection probability of the unlikely double bit errors. A key feature of the proposed ECC is that it uses the same number of check bits as the conventional single error correcting/double error detecting (SEC-DED) codes commonly used, and has nearly identical syndrome generator/encoder area and timing overhead. Hence, there is very little additional cost to using the proposed ECC. The proposed ECC can be used instead of or in addition to bit interleaving to provide greater flexibility for optimizing a memory layout and/or provide better protection from multiple bit upsets. It is also useful for small memories, e.g., content addressable memory or register files, where interleaving is not possible
High-gain, Nd-doped-glass preamplifier for the National Ignition Facility (NIF) laser system (2002)

The large Nd-doped glass laser preamplifier system for the National Ignition Facility (NIF) is comprised of 192 separate beam lines that each produce about 20 kJ of 1.05 micron light. The architecture consists of a central, all-fiber master oscillator system, where the light is generated, shaped, modulated, and distributed to 192 beam lines. Next, 192 preamplifier modules amplifier the tailored pulses from 1 nJ up to 10 J, whereupon they are transported to the large amplifier chains where the laser energy is increased to the 20 kJ level. The preamplifier modules contain a diode-pumped regenerative amplifier (regen), two optical subsystems for spatial beam shaping and smoothing by spectral dispersion (SSD), and a larger four-pass amplifier. In this paper we describe the current design and performance of this high gain preamplifier.
Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian population (2006)

An association between mutations in the glucocerebrosidase (GBA) gene and Parkinson disease (PD) was recently reported in Ashkenazi Jews. The authors screened a series of 311 Norwegian patients with PD and 474 controls for 2 common functional mutations of the GBA protein, N370S and L444P. Seven patients (2.3%) and 8 controls (1.7%) carried a mutant GBA allele (p = 0.58). This study does not indicate increased susceptibility to PD in GBA mutations carriers in Norway.
Adaptive thresholding and dynamic windowing method for automatic centroid detection of digital Shack-Hartmann wavefront sensor (2009)

A Shack-Hartmann wavefront sensor (SWHS) splits the incident wavefront into many subsections and transfers the distorted wavefront detection into the centroid measurement. The accuracy of the centroid measurement determines the accuracy of the SWHS. Many methods have been presented to improve the accuracy of the wavefront centroid measurement. However, most of these methods are discussed from the point of view of optics, based on the assumption that the spot intensity of the SHWS has a Gaussian distribution, which is not applicable to the digital SHWS. In this paper, we present a centroid measurement algorithm based on the adaptive thresholding and dynamic windowing method by utilizing image processing techniques for practical application of the digital SHWS in surface profile measurement. The method can detect the centroid of each focal spot precisely and robustly by eliminating the influence of various noises, such as diffraction of the digital SHWS, unevenness and instability of the light source, as well as deviation between the centroid of the focal spot and the center of the detection area. The experimental results demonstrate that the algorithm has better precision, repeatability, and stability compared with other commonly used centroid methods, such as the statistical averaging, thresholding, and windowing algorithms.
Calcium Electroporation: Evidence for Differential Effects in Normal and Malignant Cell Lines, Evaluated in a 3D Spheroid Model (2015)

In conclusion, calcium electroporation seems to be more effective in inducing cell death in cancer cell spheroids than in a normal fibroblast spheroid, even though intracellular ATP level is depleted in all spheroid types after treatment. These results may indicate an important therapeutic window for this therapy; although further studies are needed in vivo and in patients to investigate the effect of calcium electroporation on surrounding normal tissue when treating tumors.
Multi-Azimuth and Wide-Azimuth lessons for better seismic imaging in complex settings (2006)

In practice, acquisition and processing solutions to poor seismic illumination begin with an effort to compensate for gross holes in the density of target illumination using conventional Narrow-Azimuth streamer acquisition.As the complexity of the problem increases the case for Multi-Azimuth acquisition builds.Wide-Azimuth acquisition is required in the most challenging scenarios.Correspondingly, the processing and imaging technologies deployed must also improve in sophistication.Recent and ongoing global R&D efforts, complementing several large innovative projects, demonstrate that each of the target illumination concepts and challenges discussed here can be evaluated and contrasted in clear and unambiguous terms.
Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption (2009)

In 1991, a group of 21 scientists gathered at the Wingspread Conference Center to discuss evidence of developmental alterations observed in wildlife populations after chemical exposures. There, the term "endocrine disruptor" was agreed upon to describe a class of chemicals including those that act as agonists and antagonists of the estrogen receptors (ERs), androgen receptor, thyroid hormone receptor, and others. This definition has since evolved, and the field has grown to encompass hundreds of chemicals. Despite significant advances in the study of endocrine disruptors, several controversies have sprung up and continue, including the debate over the existence of nonmonotonic dose response curves, the mechanisms of low-dose effects, and the importance of considering critical periods of exposure in experimental design. One chemical found ubiquitously in our environment, bisphenol-A (BPA), has received a tremendous amount of attention from research scientists, government panels, and the popular press. In this review, we have covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: 1) mechanisms of BPA action; 2) levels of human exposure; 3) routes of human exposure; 4) pharmacokinetic models of BPA metabolism; 5) effects of BPA on exposed animals; and 6) links between BPA and cancer. Understanding these topics is essential for educating the public and medical professionals about potential risks associated with developmental exposure to BPA and other endocrine disruptors, the design of rigorously researched programs using both epidemiological and animal studies, and ultimately the development of a sound public health policy.
Tissue Characteristics at Microthreaded Implants: An Experimental Study in Dogs (2006)

It was suggested that the microthread configuration offered improved conditions for osseointegration.
FastPros: screening of reaction knockout strategies for metabolic engineering (2013)

Source code is freely available at http://www-shimizu.ist.osaka-u.ac.jp/shimizu_lab/FastPros/, implemented in MATLAB and COBRA toolbox.
Predicting Foot Positions for Manual Materials Handling Tasks (2005)

<div class="htmlview paragraph">For many industrial tasks (push, pull, lift, carry, etc.), restrictions on grip locations and visibility constrain the hand and head positions and help to define feasible postures. In contrast, foot locations are often minimally constrained and an ergonomics analyst can choose several different stances in selecting a posture to analyze. Also, because stance can be a critical determinant of a biomechanical assessment of the work posture, the lack of a valid method for placing the feet of a manikin with respect to the task compromises the accuracy of the analysis. To address this issue, foot locations and orientations were captured in a laboratory study of sagittal plane and asymmetric manual load transfers. A pilot study with four volunteers of varying anthropometry approached a load located on one of three shelves and transferred the load to one of six shelves. The data illustrate foot placements and behaviors that depend on pickup heights, the use of one or two hands to grasp the object, and the participants' body dimensions. Two distinct pickup and delivery strategies were observed. Split stance, with one foot in front of the other, was markedly more frequent than parallel stance with the feet side by side. A statistical model was developed to predict foot placements at load pickup. This study confirms the importance of this topic and provides the basis for the much more comprehensive study that is now underway.</div>