gebhart/patrepeval huggingface dataset:
前白血病状態に関する臨床的研究 第三編 再生不良性貧血様前白血病状態と急性白血病との関連 (1975)

Recently some cases of atypical leukemia have been reported. The term of atypical leukemia is usually applied to cases with aleukemic findings, hypoplastic or hypocellular marrow and a low percentage of leukemic cells. On the other hand, some cases with a benign course were reported as smoldering acute lenkemia, It has been already ascertained that hypoplastic preleukemic stage is different from so-called hypoplastic anemia and the leukemic process is progressing latently at that time. However, whether this stage can be seen in all leukemic cases or in only some limitted types is still unknown. In this paper, this problem was studied through clical and hematological examinations of 7 cases with hypoplastic preleukemic stage, 22 cases of atypical leukemia and 80 cases of typical acute myelocytic leukemia. 1. Hypoplastic preleukemic stage and atypical leukemia tended to be more frequently seen in elderly males. In these 2 groups the absence of splenomegaly was thought to be a characteristic finding compared with typical leukemia. 2. Ten of 22 cases of atypical leukemia were treated under the clinical diagnosis of hypoplastic anemia untill the diagnosis of leukemia was made in our clinic. Retrospective examinations of bone marrow smear were done in 5 of these 10 cases. One of these cases was diagnosed to be leukemia at that time. Four cases denied to be leukemia, however, they were thought to have hypoplastic preleukemic stage at that time because of the presence of a slight increase of myeloblasts or a left shift of granulocyte series and a relative erythroid hyperplasia. On the other hand, these preleukemic changes were not observed in cases of typical leukemia. 4. Most of hypoplastic preleukemic cases and atypical leukemia showed atypical hematological findings during all their clinical courses. 5. Median survival times from the presumptive onset of leukemia and from the diagnosis of leukemia were 13.5 months and 3.3 months in 7 cases with hypoplastic preleukemic stage (excluding one unknown case). In 22 cases of atypical leukemia (excluding 3 unknown cases) they were 10.0 months and 4.5 months, respectively. On the other hand, most patients with typical leukemia treated with the same agents as those used for the above 2 groups died within 3 months. These results suggest that not all leukemia is not preceded by hypoplastic preleukemic stage and also suggest that there may be a close relationship between this stage and atypical leukemia described as "hypoplastic leukemia" and "low percentage leukemia". Furtheremore, these cases included hypoplastic preleukemia and atypical leukemia may correspond clinically to the so- "called smoldering acute leukemia."
Chinese Medicinal Herbs Inhibit Growth of Murine Renal Cell Carcinoma (1994)

Tumors are known to produce factors suppressing immune functions. We previously showed that a murine renal cell carcinoma (Renca) suppressed macrophage function in vitro and that this suppression was abolished by co-incubation with extracts of two Chinese medicinal herbs. We now report that these phytochemicals are capable of inhibiting growth of Renca in vivo. BALB/c mice were transplanted intraperitoneally (IP) with 1-2 x 10(5) Renca cells. One day after tumor transplant, mice were randomized into two groups. One group was treated IP, daily for 10 days, with 100 microliters of phytochemicals containing 500 micrograms each of Astragalus membranaceus and Ligustrum lucidum, while the other group received saline as controls. A cure rate of 57% was obtained with these phytochemicals when the initial tumor load was 2 x 10(5), and 100% when the initial tumor load was 1 x 10(5). Additional experiments were performed to investigate the mechanisms involved in this protection. Splenic macrophages from tumor-bearing mice were shown to have depressed chemiluminescent oxidative burst activity, and this depression was restored with phytochemical treatment. Splenocytes from mice transplanted with Renca responded less favorably to interleukin-2 (IL-2) in generating lymphokine-activated killer (LAK) cells; again this depression was restored with phytochemical treatment. Our data suggest that these phytochemicals may have exerted their antitumor effects via augmentation of phagocyte and LAK cell activities.
Histogram-Equalization based Adaptive Image Sensor for real-time Vision (1996)

This paper presents an adaptive random access image sensor by using in situ histogram equalization. With this histogram equalization based adaptation, this retina can adapt automatically to different lighting conditions without any opto-mechanical adjustment. Besides its analogue output remains in a constant dynamic range and this improves the post image coding and processing efficiency. A 64×64-pixel prototype chip has been designed and fabricated in a classic 1um Single-Poly Double-Metal CMOS technology. This prototype chip works correctly and demonstrated all the expected adaptive behavior.
Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs (2008)

Tregs are important mediators of immune tolerance to self antigens, and it has been suggested that Treg inactivation may cause autoimmune disease. Therefore, immunotherapy approaches that aim to restore or expand autoantigen-specific Treg activity might be beneficial for the treatment of autoimmune disease. Here we report that Treg-mediated suppression of autoimmune disease can be achieved in vivo by taking advantage of the ability of the liver to promote immune tolerance. Expression of the neural autoantigen myelin basic protein (MBP) in the liver was accomplished stably in liver-specific MBP transgenic mice and transiently using gene transfer to liver cells in vivo. Such ectopic MBP expression induced protection from autoimmune neuroinflammation in a mouse model of multiple sclerosis. Protection from autoimmunity was mediated by MBP-specific CD4+CD25+Foxp3+ Tregs, as demonstrated by the ability of these cells to prevent disease when adoptively transferred into nontransgenic mice and to suppress conventional CD4+CD25- T cell proliferation after antigen-specific stimulation with MBP in vitro. The generation of MBP-specific CD4+CD25+Foxp3+ Tregs in vivo depended on expression of MBP in the liver, but not in skin, and occurred by TGF-beta-dependent peripheral conversion from conventional non-Tregs. Our findings indicate that autoantigen expression in the liver may generate autoantigen-specific Tregs. Thus, targeting of autoantigens to hepatocytes may be a novel approach to prevention or treatment of autoimmune diseases.
Standardized Protocols for Quality Control of MRM-based Plasma Proteomic Workflows (2012)

Mass spectrometry (MS)-based proteomics is rapidly emerging as a viable technology for the identification and quantitation of biological samples, such as human plasma--the most complex yet commonly employed biofluid in clinical analyses. The transition from a qualitative to quantitative science is required if proteomics is going to successfully make the transition to a clinically useful technique. MS, however, has been criticized for a lack of reproducibility and interlaboratory transferability. Currently, the MS and plasma proteomics communities lack standardized protocols and reagents to ensure that high-quality quantitative data can be accurately and precisely reproduced by laboratories across the world using different MS technologies. Toward addressing this issue, we have developed standard protocols for multiple reaction monitoring (MRM)-based assays with customized isotopically labeled internal standards for quality control of the sample preparation workflow and the MS platform in quantitative plasma proteomic analyses. The development of reference standards and their application to a single MS platform is discussed herein, along with the results from intralaboratory tests. The tests highlighted the importance of the reference standards in assessing the efficiency and reproducibility of the entire bottom-up proteomic workflow and revealed errors related to the sample preparation and performance quality and deficits of the MS and LC systems. Such evaluations are necessary if MRM-based quantitative plasma proteomics is to be used in verifying and validating putative disease biomarkers across different research laboratories and eventually in clinical laboratories.
Characterization of the genome and silk-gland transcriptomes of Darwin’s bark spider (Caerostris darwini) (2022)

Natural silks crafted by spiders comprise some of the most versatile materials known. Artificial silks-based on the sequences of their natural brethren-replicate some desirable biophysical properties and are increasingly utilized in commercial and medical applications today. To characterize the repertoire of protein sequences giving silks their biophysical properties and to determine the set of expressed genes across each unique silk gland contributing to the formation of natural silks, we report here draft genomic and transcriptomic assemblies of Darwin's bark spider, Caerostris darwini, an orb-weaving spider whose dragline is one of the toughest known biomaterials on Earth. We identify at least 31 putative spidroin genes, with expansion of multiple spidroin gene classes relative to the golden orb-weaver, Trichonephila clavipes. We observed substantial sharing of spidroin repetitive sequence motifs between species as well as new motifs unique to C. darwini. Comparative gene expression analyses across six silk gland isolates in females plus a composite isolate of all silk glands in males demonstrated gland and sex-specific expression of spidroins, facilitating putative assignment of novel spidroin genes to classes. Broad expression of spidroins across silk gland types suggests that silks emanating from a given gland represent composite materials to a greater extent than previously appreciated. We hypothesize that the extraordinary toughness of C. darwini major ampullate dragline silk may relate to the unique protein composition of major ampullate spidroins, combined with the relatively high expression of stretchy flagelliform spidroins whose union into a single fiber may be aided by novel motifs and cassettes that act as molecule-binding helices. Our assemblies extend the catalog of sequences and sets of expressed genes that confer the unique biophysical properties observed in natural silks.
Performance Analysis for Blob Tracking Based on Mean Shift Algorithm (2009)

A bottom-up moving object tracking method through target feature extraction and location is introduced,the performance is analysed and studied by experiment.The feature histogram based target representations are regularized by spatial masking with an isotropic kernel.Then the target location problem can be formulated using the basin of attraction of the local maxima.Using the mean shift procedure to perform the optimization,and find the one from search object modes which is most similar to target object mode.Simulation experiment is used to analyse and study the applicability,robustness and real-time performance of Mean Shift algorithm equipped in non-rigid target tracking application.Finally,some methods to improve the algorithm are proposed.
Knives are picked before slices are cut (2013)

In this paper, we introduce a model to classify cooking activities using their visual and temporal coherence information. We fuse multiple feature descriptors for fine-grained activity recognition as we would need every single detail to catch even subtle differences between classes with low inter-class variance. Considering the observation that daily activities such as cooking are likely to be performed in sequential patterns of activities, we also model temporal coherence of activities. By combining both aspects, we show that we can improve the overall accuracy of cooking recognition tasks.
Switchgrass Biomass Production in the Midwest USA (2002)

Information on optimal harvest periods and N fertilization rates for switchgrass ( Panicum virgatum L.) grown as a biomass or bioenergy crop in the Midwest USA is limited. Our objectives were to determine optimum harvest periods and N rates for biomass production in the region. Established stands of ‘Cave‐in‐Rock’ switchgrass at Ames, IA, and Mead, NE, were fertilized 0, 60, 120, 180, 240, or 300 kg N ha −1 . Harvest treatments were two‐ or one‐cut treatments per year, with initial harvest starting in late June or early July (Harvest 1) and continuing at approximately 7‐d intervals until the latter part of August (Harvest 7). A final eighth harvest was completed after a killing frost. Regrowth was harvested on previously harvested plots at that time. Soil samples were taken before fertilizer was applied in the spring of 1994 and again in the spring of 1996. Averaged over years, optimum biomass yields were obtained when switchgrass was harvested at the maturity stages R3 to R5 (panicle fully emerged from boot to postanthesis) and fertilized with 120 kg N ha −1 . Biomass yields with these treatments averaged 10.5 to 11.2 Mg ha −1 at Mead and 11.6 to 12.6 Mg ha −1 at Ames. At this fertility level, the amount of N removed was approximately the same as the amount applied. At rates above this level, soil NO 3 –N concentrations increased.
Proposal for automation of humanitarian demining with buggy robots (2004)

Landmines represent a clear threat to the civilian population in war-ravaged countries, and hamper peacekeeping and reconstruction efforts. The seriousness of this issue demands immediate automation of the mine detection and removal tasks, but until now only partial mechanization has been available. This paper proposes a versatile and feasible automated system based on mobile platforms to improve humanitarian demining, taking into account field requirements. Details of the development of the mobile platforms are presented, as well as experimental results. Special tools and components, also briefly described, are under development in order to maximize the range of applications of this system.
A Twist-like bHLH gene is a downstream factor of an endogenous FGF and determines mesenchymal fate in the ascidian embryos (2003)

Ascidian larvae develop mesenchyme cells in their trunk. A fibroblast growth factor (FGF9/16/20) is essential and sufficient for induction of the mesenchyme in Ciona savignyi. We have identified two basic helix-loop-helix (bHLH) genes named Twist-like1 and Twist-like2 as downstream factors of this FGF. These two genes are phylogenetically closely related to each other, and were expressed specifically in the mesenchymal cells after the 110-cell stage. Gene-knockdown experiments using a specific morpholino oligonucleotide demonstrated that Twist-like1 plays an essential role in determination of the mesenchyme and that Twist-like2 is a downstream factor of Twist-like1. In addition, both overexpression and misexpression of Twist-like1 converts non-mesenchymal cells to mesenchymal cells. We also demonstrate that the upstream regulatory mechanisms of Twist-like1 are different between B-line mesenchymal cells and the A-line mesenchymal cells called 'trunk lateral cells'. FGF9/16/20 is required for the expression of Twist-like1 in B-line mesenchymal precursor cells, whereas FGF, FoxD and another novel bHLH factor called NoTrlc are required for Twist-like1 to be expressed in the A-line mesenchymal precursor cells. Therefore, two different but partially overlapping mechanisms are required for the expression of Twist-like1 in the mesenchymal precursors, which triggers the differentiation of the mesenchyme in Ciona embryos.
BNT162b2-Elicited Neutralization against New SARS-CoV-2 Spike Variants (2021)

BNT162b2 Vaccine and Emerging SARS-CoV-2 Variants A total of 20 serum samples from 15 persons who received the BNT162b2 vaccine showed strong neutralization activity against recombinant viruses eng...
The Potential of Use Basil and Rosemary Essential Oils as Effective Antibacterial Agents (2013)

The considerable therapeutical problems of persistent infections caused by multidrug-resistant bacterial strains constitute a continuing need to find effective antimicrobial agents. The aim of this study was to demonstrate the activities of basil (Ocimum basilicum L.) and rosemary (Rosmarinus officinalis L.) essential oils against multidrug- resistant clinical strains of Escherichia coli. A detailed analysis was performed of the resistance of the drug to the strains and their sensitivity to the tested oils. The antibacterial activity of the oils was tested against standard strain Escherichia coli ATCC 25922 as well as 60 other clinical strains of Escherichia coli. The clinical strains were obtained from patients with infections of the respiratory tract, abdominal cavity, urinary tract, skin and from hospital equipment. The inhibition of microbial growth by both essential oils, presented as MIC values, were determined by agar dilution. Susceptibility testing to antibiotics was carried out using disc diffusion. The results showed that both tested essential oils are active against all of the clinical strains from Escherichia coli including extended-spectrum β-lactamase positive bacteria, but basil oil possesses a higher ability to inhibit growth. These studies may hasten the application of essential oils in the treatment and prevention of emergent resistant strains in nosocomial infections.
Genetic link between Ouachita foldbelt tectonism and the Mississippi Valley–type lead-zinc deposits of the Ozarks (1986)

Research Article| November 01, 1986 Genetic link between Ouachita foldbelt tectonism and the Mississippi Valley–type lead-zinc deposits of the Ozarks David L. Leach; David L. Leach 1U.S. Geological Survey, P.O. Box 25046, M.S. 912, Denver, Colorado 80225 Search for other works by this author on: GSW Google Scholar E. Lanier Rowan E. Lanier Rowan 1U.S. Geological Survey, P.O. Box 25046, M.S. 912, Denver, Colorado 80225 Search for other works by this author on: GSW Google Scholar Author and Article Information David L. Leach 1U.S. Geological Survey, P.O. Box 25046, M.S. 912, Denver, Colorado 80225 E. Lanier Rowan 1U.S. Geological Survey, P.O. Box 25046, M.S. 912, Denver, Colorado 80225 Publisher: Geological Society of America First Online: 01 Jun 2017 Online ISSN: 1943-2682 Print ISSN: 0091-7613 Geological Society of America Geology (1986) 14 (11): 931–935. https://doi.org/10.1130/0091-7613(1986)14<931:GLBOFT>2.0.CO;2 Article history First Online: 01 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation David L. Leach, E. Lanier Rowan; Genetic link between Ouachita foldbelt tectonism and the Mississippi Valley–type lead-zinc deposits of the Ozarks. Geology 1986;; 14 (11): 931–935. doi: https://doi.org/10.1130/0091-7613(1986)14<931:GLBOFT>2.0.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGeology Search Advanced Search Abstract Fluids expelled from the Arkoma basin in response to Late Pennsylvanian–Early Permian orogenesis in the Ouachita foldbelt may have been ultimately responsible for formation of the Mississippi Valley–type lead-zinc deposits in the Ozark region of Missouri, Arkansas, Kansas, and Oklahoma. Fluid inclusions in both mineralized and barren rock record the passage of hot, saline fluids regionally throughout most of the Paleozoic section in the Ozarks. Dating studies in addition to structural and geologic observations provide further evidence for fluid migration and mineralization approximately coincident with the Ouachita orogeny.Formation of foreland basins, such as the Arkoma, during convergent tectonism creates conditions exceptionally favorable to the migration of fluids from deep sedimentary basins. Proximity to a basin whose margin has undergone some form of tectonic deformation or uplift may be the unifying factor in the genesis of Mississippi Valley–type deposits in geologically diverse settings. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Highly Rechargeable Lithium‐CO<sub>2</sub> Batteries with a Boron‐ and Nitrogen‐Codoped Holey‐Graphene Cathode (2017)

Metal-air batteries, especially Li-air batteries, have attracted significant research attention in the past decade. However, the electrochemical reactions between CO<sub>2</sub> (0.04 % in ambient air) with Li anode may lead to the irreversible formation of insulating Li<sub>2</sub> CO<sub>3</sub> , making the battery less rechargeable. To make the Li-CO<sub>2</sub> batteries usable under ambient conditions, it is critical to develop highly efficient catalysts for the CO<sub>2</sub> reduction and evolution reactions and investigate the electrochemical behavior of Li-CO<sub>2</sub> batteries. Here, we demonstrate a rechargeable Li-CO<sub>2</sub> battery with a high reversibility by using B,N-codoped holey graphene as a highly efficient catalyst for CO<sub>2</sub> reduction and evolution reactions. Benefiting from the unique porous holey nanostructure and high catalytic activity of the cathode, the as-prepared Li-CO<sub>2</sub> batteries exhibit high reversibility, low polarization, excellent rate performance, and superior long-term cycling stability over 200 cycles at a high current density of 1.0 A g<sup>-1</sup> . Our results open up new possibilities for the development of long-term Li-air batteries reusable under ambient conditions, and the utilization and storage of CO<sub>2</sub> .
Akdeniz Mineral Resources (2014)

It also has a pre-heater, a rotary kiln and an integrated cooler. In 2011 it increased CCM production and processing capacity from 14,000 tpa to 36,000 tpa. The rotary kiln has the capacity to produce over 50 tpd CCM.

The company is only targeting the CCM market. Commercial production from the new kiln started in January 2012 being achieved with extremely positive results both from a technical/operational and product quality point of view, AMK's CEO Muzaffer Bayazit told IM at the time.

The new investment will make it possible for us to further develop and produce new, more sophisticated CCM high purity grades with enhanced physical properties - such as increased specific surface areas up to 90m[superscript]2 /g - which will widen our current product portfolio, he added.
Arrayed miniature electron beam columns for high throughput sub-100 nm lithography (1992)

In recent years, considerable progress has been made on an approach based on a novel concept which combines scanning tunneling microscope, microfabricated lenses, and field emission technologies to achieve microminiaturized low-voltage electron beam columns with performance surpassing the conventional column. High throughput lithography is a potentially very important application for these microfabricated columns which measure only millimeters in dimensions. This is to be achieved using an array of these minicolumns in parallel in a multibeam mode with one or more columns per chip. The low-voltage operation is attractive because proximity effect corrections may not need to be applied. In addition, an arrayed microcolumn system also has the potential of reducing the cost of the overall system through the compaction of the mechanical system. The throughout advantages for such an arrayed system based on different beam forming optics and pattern generation approaches will be discussed. In addition to lithography, a wide range of other applications for such an arrayed system such as testing, metrology, storage, etc., can also be considered.