gebhart/patrepeval huggingface dataset:
Study of road surface profile based on maximum entropy methods (2009)

The classical road spectrum estimation (FFT) is often used to deal with the data in traditional road spectum testing. The test datum after windowed often leads to side-lob, false peaks and low precise analyse result. This paper uses the maximum entropy method to cope with the road response spectum signal, analyzes the effects of the AR modeling order choosing to the road spectum estimation, gets the reasonable order, studies the energy distribution of measured grade-C road spectum and compares the difference between the classical FFT spectrum estimation and the maximum entropy estimation. The research result shows that the maxinum entropy estimation has special advantages of high resolution and little peak deviation. Using the method to deal with short records road spectum signal not only overcomes the defects of classical road spectum estimation, but also be easy to realize in projects.
B-RAF Mutant Alleles Associated with Langerhans Cell Histiocytosis, a Granulomatous Pediatric Disease (2012)

Our data confirmed presence of the (V600E)B-RAF mutation in LCH granuloma of some patients, and identify two novel B-RAF mutations. They indicate that (V600E)B-RAF and (600DLAT)B-RAF mutations are somatic mutants enriched in LCH CD1a(+) cells and absent from the patient blood. Further studies are needed to assess the functional consequences of the germ-line (T599A)B-RAF allele.
The Role of RNA Editing in Cancer Development and Metabolic Disorders (2018)

Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago. RNA editing alters RNA sequence without altering the sequence or integrity of genomic DNA. The most common RNA editing events are A-to-I changes mediated by adenosine deaminase acting on RNA (ADAR), and C-to-U editing mediated by apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1). Both A-to-I and C-to-U editing were first identified in the context of embryonic development and physiological homeostasis. The role of RNA editing in human disease has only recently started to be understood. In this review, the impact of RNA editing on the development of cancer and metabolic disorders will be examined. Distinctive functions of each RNA editase that regulate either A-to-I or C-to-U editing will be highlighted in addition to pointing out important regulatory mechanisms governing these processes. The potential of developing novel therapeutic approaches through intervention of RNA editing will be explored. As the role of RNA editing in human disease is elucidated, the clinical utility of RNA editing targeted therapies will be needed. This review aims to serve as a bridge of information between past findings and future directions of RNA editing in the context of cancer and metabolic disease.
Prediction of aggregation rate and aggregation‐prone segments in polypeptide sequences (2005)

The reliable identification of beta-aggregating stretches in protein sequences is essential for the development of therapeutic agents for Alzheimer's and Parkinson's diseases, as well as other pathological conditions associated with protein deposition. Here, a model based on physicochemical properties and computational design of beta-aggregating peptide sequences is shown to be able to predict the aggregation rate over a large set of natural polypeptide sequences. Furthermore, the model identifies aggregation-prone fragments within proteins and predicts the parallel or anti-parallel beta-sheet organization in fibrils. The model recognizes different beta-aggregating segments in mammalian and nonmammalian prion proteins, providing insights into the species barrier for the transmission of the prion disease.
Water‐soluble fluorescent polymers that respond to singlet oxygen (2016)

ABSTRACT Although acenes with more than three fused rings can both fluoresce efficiently and react with singlet oxygen ( 1 O 2 ) rapidly, their hydrophobic nature presents a challenge to their use in aqueous environments. Herein we report a series of fluorescent, water‐soluble random copolymers that each comprise (oligoethylene glycol) methacrylate (OEGMA) and one of several diarylacene methacrylates, including a tetracene methacrylate and a tetraceneothiophene methacrylate. Exposure to 1 O 2 in water oxidizes the pendant acenes, resulting in diminution of their fluorescence intensities. The observed rate of oxidation of the tetracene‐containing polymers compares favorably with a commercial 1 O 2 ‐sensitive dye. Polymers that also include energy‐donating coumarin side chains show ratiometric fluorescence changes in response to 1 O 2 . © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54 , 2526–2535
Crystal structure of catena-(hexakis(.2-3,5-dinitrobenzoate-O,O')- tetrakis(dimethylsulfoxide-O)dilanthanum(III), La2[(C7H3N2O6)6(C2H6SO)4] (2011)

Article Crystal structure of catena-(hexakis(.2-3,5-dinitrobenzoate-O,O')- tetrakis(dimethylsulfoxide-O)dilanthanum(III), La2[(C7H3N2O6)6(C2H6SO)4] was published on December 1, 2011 in the journal Zeitschrift für Kristallographie - New Crystal Structures (volume 226, issue 4).
Akt Signaling Mediates Postnatal Heart Growth in Response to Insulin and Nutritional Status (2002)

Akt is a serine-threonine kinase that mediates a variety of cellular responses to external stimuli. During postnatal development, Akt signaling in the heart was up-regulated when the heart was rapidly growing and was down-regulated by caloric restriction, suggesting a role of Akt in nutrient-dependent regulation of cardiac growth. Consistent with this notion, reductions in Akt, 70-kDa S6 kinase 1, and eukaryotic initiation factor 4E-binding protein 1 phosphorylation were observed in mice with cardiac-specific deletion of insulin receptor gene, which exhibit a small heart phenotype. In contrast to wild type animals, caloric restriction in these mice had little effect on Akt phosphorylation in the heart. Furthermore, forced expression of Akt1 in these hearts restored 70-kDa S6 kinase 1 and eukaryotic initiation factor 4E-binding protein 1 phosphorylation to normal levels and rescued the small heart phenotype. Collectively, these results indicate that Akt signaling mediates insulin-dependent physiological heart growth during postnatal development and suggest a mechanism by which heart size is coordinated with overall body size as the nutritional status of the organism is varied.
Measurement of the absolute CF<sub>2</sub>concentration in a dielectric barrier discharge running in argon/fluorocarbon mixtures (2004)

The role of different CFx-radicals in plasma polymerization in fluorocarbon mixtures has not been determined yet. Therefore spectroscopic investigations of dielectric barrier discharges (DBDs) in argon/fluorocarbon mixtures at atmospheric pressure were conducted with the focus on measurement of the concentration of CFx-radicals. The following diagnostic procedures were applied: FTIR absorption spectroscopy to diagnose stable compounds in the discharge, optical emission spectroscopy of the DBD in the UV and visible range and measurement of the CF2 concentration by UV absorption spectroscopy. The DBD was running in argon with the following admixtures: CF4, C2F6, C2H2F4, C3F8, C3HF7, c-C4F8. The relative concentration of the CF3-radical and the absolute concentration of CF2 in Ar/fluorocarbon mixtures were measured by emission spectroscopy and by absorption and emission spectroscopy, respectively. Emission and absorption spectroscopy were performed simultaneously in combination with electrical measurements of the discharge characteristics. The influence of small amounts of hydrogen or oxygen added to the argon/fluorocarbon mixtures was investigated.
Towards Exploiting Background Knowledge for Building Conversation Systems (2018)

Existing dialog datasets contain a sequence of utterances and responses without any explicit background knowledge associated with them. This has resulted in the development of models which treat conversation as a sequenceto-sequence generation task (i.e., given a sequence of utterances generate the response sequence). This is not only an overly simplistic view of conversation but it is also emphatically different from the way humans converse by heavily relying on their background knowledge about the topic (as opposed to simply relying on the previous sequence of utterances). For example, it is common for humans to (involuntarily) produce utterances which are copied or suitably modified from background articles they have read about the topic. To facilitate the development of such natural conversation models which mimic the human process of conversing, we create a new dataset containing movie chats wherein each response is explicitly generated by copying and/or modifying sentences from unstructured background knowledge such as plots, comments and reviews about the movie. We establish baseline results on this dataset (90K utterances from 9K conversations) using three different models: (i) pure generation based models which ignore the background knowledge (ii) generation based models which learn to copy information from the background knowledge when required and (iii) span prediction based models which predict the appropriate response span in the background knowledge.
Screen-Printable and Flexible RuO<sub>2</sub> Nanoparticle-Decorated PEDOT:PSS/Graphene Nanocomposite with Enhanced Electrical and Electrochemical Performances for High-Capacity Supercapacitor (2015)

PSS/graphene surfaces facilitated redox reactions with the surrounding electrolyte, and significantly enhanced the specific capacitance of the electrode materials. The resulting RuO2/PEDOT:PSS/graphene electrode with a thickness of ∼5 μm exhibited high conductivity (1570 S cm(-1)), a large specific capacitance (820 F g(-1)), and good cycling stability (81.5% after 1000 cycles).
HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP) (2006)

The HTLV-1 transactivator protein Tax is essential for malignant transformation of CD4 T cells, ultimately leading to adult T-cell leukemia/lymphoma (ATL). Malignant transformation may involve development of apoptosis resistance. In this study we investigated the molecular mechanisms by which HTLV-1 Tax confers resistance toward CD95-mediated apoptosis. We show that Tax-expressing T-cell lines derived from HTLV-1-infected patients express elevated levels of c-FLIP(L) and c-FLIP(S). The levels of c-FLIP correlated with resistance toward CD95-mediated apoptosis. Using an inducible system we demonstrated that both resistance toward CD95-mediated apoptosis and induction of c-FLIP are dependent on Tax. In addition, analysis of early cleavage of the BH3-only Bcl-2 family member Bid, a direct caspase-8 substrate, revealed that apoptosis is inhibited at a CD95 death receptor proximal level in Tax-expressing cells. Finally, using siRNA we directly showed that c-FLIP confers Tax-mediated resistance toward CD95-mediated apoptosis. In conclusion, our data suggest an important mechanism by which expression of HTLV-1 Tax may lead to immune escape of infected T cells and, thus, to persistent infection and transformation.
Angiotensin I converting enzyme and the changes in our concepts through the years. Lewis K. Dahl memorial lecture. (1990)

Changes in our concepts of angiotensin I converting enzyme are reviewed briefly. The actions of this enzyme go beyond liberating angiotensin II from angiotensin I or inactivating bradykinin. Its very wide distribution in the body and its activity in vitro indicate involvement in the metabolism of other biologically active peptides. The recent molecular cloning of the human enzyme confirmed the existence of a hydrophobic C-terminal peptide that forms the short transmembrane domain of this plasma membrane-bound enzyme. The much longer external portion contains two homologous active site domains but probably only one functional active center. Finally, in spite of the great progress made in studying angiotensin converting enzyme, there are many challenging problems waiting to be solved.
Design choices for the TOP-1 multiprocessor workstation (1991)

A snoopy-cache-based multiprocessor workstation called TOP-1 (TOkyo research Parallel processor-1) was developed to evaluate multiprocessor architecture design choices as well as to conduct research on operating systems, compilers, and applications for multiprocessor workstations. TOP-1 is a ten-way multiprocessor using the Intel 80386™ microprocessor chip and the Weitek WTL 1167™ floating-point coprocessor chip. It is currently running under a multiprocessor version of AIX® , which was also developed at the IBM Tokyo Research Laboratory. Our research interest was focused on the design of an effective snoopy cache (all caches monitor all memory-cache traffic) system and the quantitative evaluation of its performance. One of the unique aspects of the TOP-1 design is that the cache supports four different, original snoopy protocols, which may coexist in the system. To evaluate the performance, we implemented a hardware statistics monitor that gathers statistical data. This paper focuses mainly on the TOP-1 cache design—its protocol, and its evaluation by means of the statistics monitor. Besides its cache design, TOP-1 has three other unique architectural features: two independently arbitrated 64-bit buses supported by two snoopy-cache controllers per processor, a communication and interruption mechanism for notifying other processors of asynchronous events, and an efficient arbitration mechanism to allow prioritized quasi-round-robin service with distributed control. These features are also described in detail.
The Mannose-Sensitive Hemagglutinin of<i>Vibrio cholerae</i>Promotes Adherence to Zooplankton (2001)

The bacterium Vibrio cholerae, the etiological agent of cholera, is often found attached to plankton, a property that is thought to contribute to its environmental persistence in aquatic habitats. The V. cholerae O1 El Tor biotype and V. cholerae O139 strains produce a surface pilus termed the mannose-sensitive hemagglutinin (MSHA), whereas V. cholerae O1 classical biotype strains do not. Although V. cholerae O1 classical does not elaborate MSHA, the gene is present and expressed at a level comparable to that of the other strains. Since V. cholerae O1 El Tor and V. cholerae O139 have displaced V. cholerae O1 classical as the major epidemic strains over the last fifteen years, we investigated the potential role of MSHA in mediating adherence to plankton. We found that mutation of mshA in V. cholerae O1 El Tor significantly diminished, but did not eliminate, adherence to exoskeletons of the planktonic crustacean Daphnia pulex. The effect of the mutation was more pronounced for V. cholerae O139, essentially eliminating adherence. Adherence of the V. cholerae O1 classical mshA mutant was unaffected. The results suggest that MSHA is a factor contributing to the ability of V. cholerae to adhere to plankton. The results also showed that both biotypes of V. cholerae O1 utilize factors in addition to MSHA for zooplankton adherence. The expression of MSHA and these additional, yet to be defined, adherence factors differ in a serogroup- and biotype-specific manner.
Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies (2011)

Protein microarrays offer a global perspective on the function of expressed gene products. However, technical issues related to the stability and dynamic range of microarrays printed with purified protein have hampered their widespread adoption. Taking an alternate approach, the Nucleic Acid Programmable Protein Array (NAPPA) is constructed by spotting protein-encoding plasmid DNA at high density, in addressable fashion, on an array surface. Proteins are subsequently generated in situ just prior to experimentation using cell-free expression systems. As such, the NAPPA platform offers a unique and viable alternative that circumvents many of the inherent limitations of spotted protein arrays, enabling diverse functional protein studies including protein-small molecule, protein-protein, antigen-antibody, and protein-nucleic acid interactions. It further offers a versatile and adaptable platform amenable to a variety of capture modalities and expression systems, and, most importantly, construction of the array is accessible to any lab with an array printer and laser slide scanner. This unit is intended to provide a reference for investigators wishing to generate arrays based on this platform, and details (1) the basic construction of cDNA-based protein microarrays from DNA isolation to printing and development, (2) quality-control efforts taken to ensure the usefulness and integrity of microarray data, and (3) a particular example of the application of self-assembling protein arrays to screen for blood-borne antibody biomarkers.
Big Data and Visuality (2017)

Internet and telecommunications, ubiquitous sensing devices, and advances in data storage and analytic capacities have heralded the age of <italic>Big Data</italic>, where the volume, velocity, and variety of data not only promise new opportunities for the harvesting of information, but also threaten to overload existing resources for making sense of this information. The use of Big Data technology for criminal justice and crime control is a relatively new development. Big Data technology has overlapped with criminology in two main areas: (a) Big Data is used as a type of <italic>data</italic> in criminological research, and (b) Big Data analytics is employed as a predictive tool to guide criminal justice decisions and strategies. Much of the debate about Big Data in criminology is concerned with legitimacy, including privacy, accountability, transparency, and fairness. Big Data is often made accessible through data visualization. Big Data visualization is a performance that simultaneously masks the power of commercial and governmental surveillance and renders information political. The production of visuality operates in an economy of attention. In crime control enterprises, future uncertainties can be masked by affective triggers that create an atmosphere of risk and suspicion. There have also been efforts to mobilize data to expose harms and injustices and garner support for resistance. While Big Data and visuality can perform affective modulation in the race for attention, the impact of data visualization is not always predictable. By removing the visibility of real people or events and by aestheticizing representations of tragedies, data visualization may achieve further distancing and deadening of conscience in situations where graphic photographic images might at least garner initial emotional impact.
A zero voltage switching flyback converter topology (2002)

A zero voltage switching flyback power converter topology employing an auxiliary circuit is presented in this paper. The proposed power converter has lossless switching (whatever the line and load conditions), few components and can be operated either in voltage or current mode control. A detailed analysis of the circuit is presented and the design procedure is illustrated. A 50 W 200 kHz prototype zero voltage switching flyback power converter is built which shows an efficiency improvement of approximately 7% as compared to a conventional hard switching flyback power converter.
ASPECTOS BÁSICOS PARA UNA ENSEÑANZA E-LEARNING DE CALIDAD EN LA EDUCACIÓN SUPERIOR (2016)

En el presente artículo vamos a tratar la importancia de los diferentes aspectos que contribuyen en una enseñanza e-learning en el ámbito educativo superior. Para ello, trataremos diferentes conceptos esenciales para que una enseñanza de este tipo sea de una calidad óptima.
Active-passive detection of multipixel targets (1990)

Multifunction laser radar systems can collect two-dimensional target images of intensity, range, or velocity, and many such systems augment their active-sensor channel with a FLIR channel. This paper addresses the problem of optimal target detection using such an active-passive sensor, focusing on the performance benefits that accrue when multidimensional data-active-sensor range, velocity, and intensity, plus passive-sensor intensity - are combined in the detection processor. Generalized likelihood ratio tests are derived for active-passive detection processing, and quantitative performance results - receiver operating characteristics - are obtained through computer simulation of pixel-level statistics. The performance predictions for the gamut of multidimensional, multipixel detection processors are confirmed via experiments performed using a multidimensional laser radar test bed.
Properties of Carbide-Metal Cermets Prepared from Composite Powders by Direct Reduction and Carburization Process (2008)

The transition-metal carbide cemented by metal has excellent combined properties. In this study, cermets were prepared by vacuum sintering from carbide-metal composite powders. The transition- metal oxides (Cr2O3, MoO3, V2O5, Nb2O5 and TiO2), cementing-metal oxides (Co3O4 and NiO), and carbon black were used as raw materials to pre-synthesize composite powders such as Cr3C2-Co, Mo2C-Co, VC-Co, NbC-Co and TiC-Ni, by a direct reduction and carburization process in vacuum. Results show that the participation of Co3O4 and NiO as well as the vacuum circumstance were greatly propitious to the carburization of transition-metal oxides into carbides. The carbothermal condition was greatly improved by the direct reduction and carburization process.
Different Methods for Assessing the Features of Eating Disorders in Patients with Binge Eating Disorder: A Replication (2001)

In patients with BED, the three assessment methods showed some areas of acceptable convergence.
Energy Transfer from Nucleic Acids to Tb(III):  Selective Emission Enhancement by Single DNA Mismatches (1998)

Enhanced luminescence resulting from energy transfer (EnT) from nucleic acids to Tb3+ has been utilized to investigate the binding of the ions to the bases and nucleotides, as well as in the detection of single mismatches in duplexes. Cytosine enhances the Tb3+ emission, but dCMP does not, indicating that the lanthanide bound to the phosphate group is too far away from the base for efficient energy transfer. Conversely, the enhancement of the Tb3+ luminescence by dGMP is greater than that of G, where the phosphate appears to aid in the binding of the ion to the base. We propose that the phosphate group in dGMP is able to fold over and permit coordination of the ion to the O6 and N7 atoms of the base while still bound to the anionic phosphate oxygens, thus increasing the binding affinity and promoting efficient EnT. Single-stranded oligonucleotides greatly enhance the Tb3+ emission, but duplexes do not. Single mismatches in the sequence of a duplex lead to selective luminescence enhancement in the presence of Tb3+. The largest enhancement was observed for the GG mismatch, followed by CA, GA, and CC, and the smallest emission intensity was measured for TT and TG mismatches. The unexpected role of adenine in the emission enhancement has been explained through preassociation of the Tb3+, thus permitting A to be in the coordination sphere of the ion. It was concluded that A is able to transfer energy to Tb3+ when bound to the ion, but in the absence of the supramolecular assembly, it cannot coordinate strongly enough to the lanthanide to effect EnT. The low emission enhancement by the TG mismatch has been explained in terms wobble pair formation. These findings show that the enhanced emission of lanthanides can be successfully utilized to selectively detect single mismatches in duplexes.