gebhart/patrepeval huggingface dataset:
Energy Harvesting Performance of Printed Barium Titanate Nanocomposites (2018)

Development of nanostructured devices for sensing, energy storage, actuating, and energy harvesting has attracted many researchers. The most common type of functional nanostructures is piezoelectric nanomaterials. Regardless of numerous studies in this area, there is a need for rapid fabrication of nanostructured devices, or simply functional nanocomposites. Here we present a simple, scalable fabrication technique for additive manufacturing of nanocomposite energy harvesting devices composed of barium titanate nanowires. Details on hydrothermal synthesis of barium titanate (BaTiO3) nanowires and printable inks, manufacturing process, and energy harvesting performance of the printed devices are presented here. The experimental results suggest that additive manufacturing of functional nanocomposites allows controlling the microstructures and enhancing device performance.
Disturbance Extraction for Burst Detection in Water Distribution Networks Using Pressure Measurements (2020)

Abstract Pipe bursts in water distribution networks cause considerable water losses and lead to potential environmental hazards. Effective burst detection methods enable water companies to repair broken pipes in a timely manner and minimize damage and disruption. A data‐driven detection method is developed and proven for real‐time leak and burst detection in water distribution networks. The method uses a unique integration of disturbance extraction and isolation forest techniques to enable detection of subtle burst signals from normally noisy pressure data. Verification and validation progress from synthetic data to the application to real‐life data from large‐scale open networks. The method is shown to generate comparable levels of detection, with low false positive rates, to other published techniques but without the need to introduce closed valves and expensive flow meters of district meter area structures and the loss of resilience these cause. The method offers the potential to effectively detect bursts from pressure data alone, helping to better manage the distribution of increasingly stressed water resources through aging pipe networks.
A new telogen for telechelic oligomers of chlorotrifluoroethylene (1991)

R. D. Chambers, M. P. Greenhall, A. P. Wright and G. Caporiccio, J. Chem. Soc., Chem. Commun., 1991, 1323 DOI: 10.1039/C39910001323
<i>miR-146a</i> controls the resolution of T cell responses in mice (2012)

T cell responses in mammals must be tightly regulated to both provide effective immune protection and avoid inflammation-induced pathology. NF-κB activation is a key signaling event induced by T cell receptor (TCR) stimulation. Dysregulation of NF-κB is associated with T cell-mediated inflammatory diseases and malignancies, highlighting the importance of negative feedback control of TCR-induced NF-κB activity. In this study we show that in mice, T cells lacking miR-146a are hyperactive in both acute antigenic responses and chronic inflammatory autoimmune responses. TCR-driven NF-κB activation up-regulates the expression of miR-146a, which in turn down-regulates NF-κB activity, at least partly through repressing the NF-κB signaling transducers TRAF6 and IRAK1. Thus, our results identify miR-146a as an important new member of the negative feedback loop that controls TCR signaling to NF-κB. Our findings also add microRNA to the list of regulators that control the resolution of T cell responses.
Miniaturization of holographic Fourier-transform spectrometers (2004)

Wave propagation equations in the stationary-phase approximation have been used to identify the theoretical bounds of a miniature holographic Fourier-transform spectrometer (HFTS). It is demonstrated that the HFTS throughput can be larger than for a scanning Fourier-transform spectrometer. Given room- or a higher-temperature constraint, a small HFTS has the potential to outperform a small multichannel dispersive spectrograph with the same resolving power because of the size dependence of the signal-to-noise ratio. These predictions are used to analyze the performance of a miniature HFTS made from simple optical components covering a broad spectral range from the UV to the near IR. The importance of specific primary aberrations in limiting the HFTS performance has been both identified and verified.
Orthogonal Time Frequency Space Multiple Access Using Index Modulation (2023)

Orthogonal time frequency space (OTFS) is a recent two-dimensional modulation technique utilizing delay-Doppler domain and nominated as a promising candidate waveform for beyond 5G communication systems. By leveraging both time and frequency selectivity of doubly-dispersive radio channels, it has shown a better performance compared to traditional schemes. OTFS offers different options for accommodating multiple users on a given resource block. This article introduces a novel OTFS based uplink multiple access scheme by means of index modulation (IM) in delay-Doppler domain. IM based OTFS multiple access (OTFS-IMMA) proposes the coexistence of multiple users over the same delay-Doppler resources. Unlike conventional OTFS multiple access schemes, OTFS-IMMA allows users to employ IM to activate a subset of the available delay-Doppler resources without a coordination by the base station. Although data collision may occur between the users, our analysis shows that the achievable performance is still better than other schemes. Moreover, the proposed OTFS-IMMA scheme paves the way for flexible resource utilization in OTFS-MA to satisfy various users' demands in beyond 5G systems. It has been shown via both mathematical analysis and simulations that the proposed OTFS-IMMA scheme offers significant enhancement not only on bit error rate performance but also on the overall system efficiency. In addition, the achieved performance gain through OTFS-IMMA further increases as the number of channel taps and/or the number of delay-Doppler bins increase.
Transient Room Lighting for Ambient Light Multiphoton Microscopy (2020)

Abstract Laser scanning microscopy techniques such as confocal and multiphoton fluorescence microscopy have been widely adopted by the biological research community due to their ability to monitor intact specimens at high spatial and temporal resolution. However, they have been limited for many biomedical, clinical and industrial applications by their fundamental need to operate in near absolute darkness. We present a lighting system that allows the use of light-sensitive imaging techniques in a fully-lit room by interleaving capture and illumination at a high frequency and exploiting the light averaging properties of the human eye. We use this system with a multiphoton fluorescence microscope to illustrate that this method is capable of image capture in a well-lit room on par with capture in absolute darkness. This comparison is quantified through noise analysis of the images. This system has been implemented for laser scanning microscopy but has potential for widefield fluorescence imaging suitable for open-field surgery.
De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells. (1995)

The rapid progress in the cloning of proteoglycan genes has enabled investigators to examine in depth the functional roles these polyhedric molecules play in the control of cell proliferation. Decorin, a leucine-rich proteoglycan expressed by most connective tissues, is a prototype molecule that regulates cellular growth via two mechanisms: modulation of growth factor activity and matrix assembly. We now provide direct evidence that human colon cancer cells stably transfected with decorin cDNA exhibit a marked suppression of the transformed phenotype: the cells have a reduced growth rate in vitro, form small colonies in soft agar, and do not generate tumors in scid/scid mice. Several independent clones are arrested in the G1 phase of the cell cycle, and their growth suppression can be restored by treatment with decorin antisense oligodeoxynucleotides. These effects are independent of growth factors and are not due to either clonal selection or integration site of the decorin gene. These findings correlate well with the observation that decorin gene expression is markedly up-regulated during quiescence. Decorin thus appears to be one component of a negative loop that controls cell growth.
Oxidative Decontamination of Tritiated Materials Employing Ozone Gas (2001)

The Princeton Plasma Physics Laboratory has developed a process by which to significantly reduce surface and near surface tritium contamination from various materials. The Oxidative Tritium Decontamination System (OTDS) reacts gaseous state ozone (accelerated by presence of catalyst), with tritium entrained/deposited on the surface of components (stainless steel, copper, plastics, ceramics, etc.), for the purpose of activity reduction by means of oxidation-reduction chemistry. In addition to removing surface and near surface tritium contamination from (high monetary value) components for reuse in non-tritium environments, the OTDS has the capability of removing tritium from the surfaces of expendable items, which can then be disposed of in a less expensive fashion. The OTDS can be operated in a batch mode by which up to approximately 40 pounds of tritium contaminated (expendable) items can be processed and decontaminated to levels permissible for free release (less than1,000 dpm/100 cm 2). This paper will discuss the OTDS process, the level of tritium surface contamination removed from various materials, and a technique for ''deep scrubbing'' tritium from subsurface layers.
Speckle-based measurement of the light scattering by red blood cells in vivo (2011)

Optical spectroscopy approach, using non-coherent light sources, has become an important tool for non-invasive analysis in vivo. It is based on the assumption that biochemical characteristics of biological system can be determined through the optical coefficients of blood and tissue particles. Thus, in the framework of this approach, the major concern is to express the obtained optical signals in terms the optical coefficients of the single particle of blood or tissue. However, since the light propagation in tissue is dominated by the multiple-scattering component, a direct measurement of single scattering characteristics turns to be a very difficult task. Practically, only the relative changes of absorption and scattering coefficients are measured. We suggested to adopt the dynamic light scattering (DLS) or speckle technique for the determination of the light scattering coefficients of the red blood cells under stasis conditions in vivo. We assumed that under zero flow conditions the RBC movement is driven mostly by the Brownian motion. It was shown, that under appropriate measurement geometry, the measured optical signal can be decomposed into a few major components. The most dominant components are ascribed to the single backscattering and forward scattering coefficients of the red blood cells. In-vitro and in vivo experimental tests have shown a good correspondence between the theoretically estimated and experientially measured results. The obtained results indicate that the DLS technique can be adopted for the determination of blood particles scattering characteristics in addition to the movement and effective viscosity parameters measurement in vivo.
Design and Modeling Methodology of Vertical Interconnects for 3DI Applications (2011)

This paper presents a design and modeling methodology of vertical interconnects for three-dimensional integration (3DI) applications. Compact semi-analytical wideband circuit level models have been developed based on explicit expressions. The pronounced frequency dependent silicon substrate induced dispersion and loss effects are considered, as well as skin and proximity effects. The models have been verified against numerical computations (full wave HFSS and quasi-static Q3D solvers). A dedicated test site has been designed for broadband characterization (from 1 MHz up to 110 GHz) of TSVs within a dense farm.
Some Observations on the Sense and Magnitude of Spontaneous Polarization and Twisting Power of a Number of Ferroelectric Liquid Crystal Types (1986)

Abstract The sense and magnitude of spontaneous polarization of a number of ferroelectric liquid crystal types were measured. Compounds with a polar group close to the chiral center showed large Ps values, amounting to 150 nC/cm2 in the highest case. The alteration of signs of Ps as the chiral center is moved stepwise from the central core in the series of compounds having an alkyl or alkoxy wing chain was examined. Compounds in which the chiral center is connected to the core by an ether linkage showed singularity. The well-known SED-ROD and SOL-REL rule for cholesterics applied to almost all the diverse types of compounds of the present study also in the S*c phase.
Evaluating distances using a coded lens camera and a blur metric (2011)

We propose a method and a system to measure distances to a target and at the same time obtaining an image of the target. The system is based on a wavefront coded lens and an image processing unit. The method requires a calibration phase where a blur metric is related to the distance of the target. The distance to the target for any position is then obtained by computing the blur metric of the target and using the calibration data. The method and system are easy to manufacture and provide an alternative to other distance measuring methods and devices, while also producing an image of the scene. The target is a printed image of pseudo random black and white elements which can be stick or placed nearby objects of which distance is to be evaluated.
Automatic Detection of Seizures with Applications (1993)

There are an estimated two million people with epilepsy in the United States. Many of these people do not respond to anti-epileptic drug therapy. Two devices can be developed to assist in the treatment of epilepsy. The first is a microcomputer-based system designed to process massive amounts of electroencephalogram (EEG) data collected during long-term monitoring of patients for the purpose of diagnosing seizures, assessing the effectiveness of medical therapy, or selecting patients for epilepsy surgery. Such a device would select and display important EEG events. Currently many such events are missed. A second device could be implanted and would detect seizures and initiate therapy. Both of these devices require a reliable seizure detection algorithm. A new algorithm is described. It is believed to represent an improvement over existing seizure detection algorithms because better signal features were selected and better standardization methods were used.
Endotoxin Reduction in Cotton: Preparation of Yarn and Fabric from Detoxified Cotton (1988)

Endotoxins, which are found in the cell walls of gram-negative bacteria, are suspected of being a causative agent of byssinosis, a pulmonary dysfunction found in some textile mill workers exposed to cotton dust. Cotton sliver and lint were treated with solvent systems previously shown to reduce the endotoxin content of cotton dust as measured by Limulus amebocyte lysate assay. Endotoxins in sliver or lint were reduced by several of the solvent systems. Yarns were spun from sliver treated with 95% ethanol containing either sodium hydroxide or hydrochloric acid. Single-knit fabric was successfully prepared from a badly weathered cotton lint treated with 95% ethanol/sodium hydroxide.
The concept of time-average-frequency and mathematical analysis of flying-adder frequency synthesis architecture (2008)

Flying-adder frequency synthesis architecture is a novel technique of generating frequency on chip. Since its invention, it has been utilized in many commercial products to cope with various difficult challenges. During the evolution of this architecture, the issues related to circuit- and system-level implementation have been studied in prior publications. However, rigorous mathematical treatment on this architecture has not been established. In this paper, we attempt to explore and understand the signal characteristics and frequency domain behavior of this architecture through mathematical analysis. In the meantime, the underlying concept associated with this architecture, time-average-frequency, is formally introduced.
Phylogenetic inference in protein superfamilies: analysis of SH2 domains. (1998)

This work focuses on the inference of evolutionary relationships in protein superfamilies, and the uses of these relationships to identify key positions in the structure, to infer attributes on the basis of evolutionary distance, and to identify potential errors in sequence annotations. Relative entropy, a distance metric from information theory, is used in combination with Dirichlet mixture priors to estimate a phylogenetic tree for a set of proteins. This method infers key structural or functional positions in the molecule, and guides the tree topology to preserve these important positions within subtrees. Minimum-description-length principles are used to determine a cut of the tree into subtrees, to identify the subfamilies in the data. This method is demonstrated on SH2-domain containing proteins, resulting in a new subfamily assignment for Src2-drome and a suggested evolutionary relationship between Nck_human and Drk_drome, Sem5_caeel, Grb2_human and Grb2_chick.
Replacement of residues 8-22 of angiogenin with 7-21 of RNase A selectively affects protein synthesis inhibition and angiogenesis (1990)

The region of human angiogenin containing residues 8-21 is highly conserved in angiogenins from four mammalian species but differs substantially from the corresponding region of the homologous protein ribonuclease A (RNase A). Regional mutagenesis has been employed to replace this segment of angiogenin with the corresponding RNase A sequence, and the activities of the resulting covalent angiogenin/RNase hybrid, designated ARH-III, have been examined. The ribonucleolytic activity of ARH-III is unchanged toward most substrates, including tRNA, naked 18S and 28S rRNA, CpA, CpG, UpA, and UpG. In contrast, the capacity of ARH-III to inhibit cell-free protein synthesis is decreased 20-30-fold compared to that of angiogenin. The angiogenic activity of ARH-III is also different; it is actually more potent. It induces a maximal response in the chick chorioallantoic membrane assay at 0.1 ng per egg, a 10-fold lower dose than required for angiogenin. In addition, binding of ARH-III to the placental ribonuclease inhibitor is increased by at least 1 order of magnitude (Ki less than or equal to 7 x 10(-17) M) compared to angiogenin. Thus, mutation of a highly conserved region of angiogenin markedly affects those properties likely involved in its biological function(s); it does not, however, alter ribonucleolytic activity toward most substrates.
TCAM Razor: A Systematic Approach Towards Minimizing Packet Classifiers in TCAMs (2007)

Packet classification is the core mechanism that enables many networking services on the Internet such as firewall packet filtering and traffic accounting. Using ternary content addressable memories (TCAMs) to perform high-speed packet classification has become the de facto standard in industry. TCAMs classify packets in constant time by comparing a packet with all classification rules of ternary encoding in parallel. Despite their high speed, TCAMs suffer from the well-known range expansion problem. As packet classification rules usually have fields specified as ranges, converting such rules to TCAM-compatible rules may result in an explosive increase in the number of rules. This is not a problem if TCAMs have large capacities. Unfortunately, TCAMs have very limited capacity, and more rules means more power consumption and more heat generation for TCAMs. Even worse, the number of rules in packet classifiers have been increasing rapidly with the growing number of services deployed on the internet. To address the range expansion problem of TCAMs, we consider the following problem: given a packet classifier, how can we generate another semantically equivalent packet classifier that requires the least number of TCAM entries? In this paper, we propose a systematic approach, the TCAM Razor, that is effective, efficient, and practical. In terms of effectiveness, our TCAM Razor prototype achieves a total compression ratio of 3.9%, which is significantly better than the previously published best result of 54%. In terms of efficiency, our TCAM Razor prototype runs in seconds, even for large packet classifiers. Finally, in terms of practicality, our TCAM Razor approach can be easily deployed as it does not require any modification to existing packet classification systems, unlike many previous range expansion solutions.
Differences between binding of one-chain and two-chain tissue plasminogen activators to non-cross-linked and cross-linked fibrin clots (1989)

Interaction of tissue plasminogen activator (t-PA) with fibrin plays a key role in regulation of plasminogen activation and clot dissolution. Previous investigations of t-PA-fibrin interaction, using incorporation of t-PA into polymerizing fibrin clots, have suggested that no significant differences exist in the binding of one-chain or two-chain t-PA to non-cross-linked or cross-linked fibrin. In the present study, binding of 125I-labeled and affinity-purified one-chain and two-chain forms of t-PA to preformed non-cross-linked or cross-linked, sonicated suspension of fibrin was investigated. Interaction of one-chain t-PA with cross-linked fibrin involved a single type of binding site with dissociation constant (kd) of 0.58 mumol/L and a stoichiometry (n) of 1.5. Interaction of one-chain t-PA with non-cross-linked fibrin, however, involved two classes of binding sites with dissociation constants of 0.32 and 1.5 mumol/L and corresponding number of binding sites equal to 0.57 and 2.0, respectively. In contrast to the binding of one-chain t-PA to cross-linked fibrin by a limited number of sites, two-chain t-PA appeared to involve a considerably greater number of sites (minimum six) whose dissociation constant was 3.2 mumol/L. Interaction of two-chain t-PA with non-cross-linked fibrin also showed the presence of many binding sites (minimum seven) with approximate dissociation constant of 6.4 mumol/L, as well as a few (n = 0.012) high-affinity sites with a kd of 0.011 mumol/L epsilon-Aminocaproic acid did not completely reverse the binding of either one-chain t-PA or two-chain t-PA to fibrin. The present findings suggest that the fibrin-binding properties of t-PA undergo considerable changes on proteolytic conversion from one-chain to two-chain t-PA, catalyzed under physiologic conditions by plasmin. The cleavage of one-chain t-PA to two-chain t-PA allows to bind to a large number of low-affinity binding sites on fibrin. Cross-linking of fibrin by factor XIIIa results in masking of high-affinity binding sites that are present in non-cross-linked fibrin. We propose that both plasmin and factor XIIIa play an important regulatory role in dissolution of blood clots by modulating t-PA-fibrin interaction.