gebhart/patrepeval huggingface dataset:
Novel Spiro Substituted Cyclotriphosphazenes Incorporating Ethylenedinitramine Units (1994)

Abstract A new initiative directed toward understanding the chemistry, synthesis, and properties of non or low carbon-based energetic compositions was undertaken. Initial synthesis work focused on reactions of hexachlorocyclotriphosphazene 1, with ethylenediamino and azido functional groups. The reaction of 1 with ethylenediamine, N,N'-dinitroethylenediamine, and N,N'-bis(trimethylsilyl)ethylenediamine yielded novel bis- and tris-spiro(ethylenediamino)cyclotriphosphazenes. Subsequent nitration with either nitronium tetrafluoroborate or nitric acid (100%) acetic anhydride gave various mono-, bis- and trisspiro(N,N'-dinitroethylenediamino)cyclotriphosphazenes. Key Words: Cyclotriphosphazenesnitraminesnitrationenergetic compounds
Tailoring of Low Chromatic Dispersion over a Broadband in Silicon Waveguides using a Double-Slot Design (2013)

We propose horizontal double-slot silicon waveguide to tailor the dispersion and achieve flattened and low dispersion with a bandwidth of 878 nm from −17 to 23 ps/(km·nm). Supercontinuum in all-normal dispersion with 3 dB bandwidth of 188 nm is generated in double-slot waveguide.
Dispersion Compensated Fiber Raman Oscillator (1986)

We have generated subpicosecond pulses from a synchronously pumped fiber Raman ring laser with a dispersion compensating delay line. The ring oscillator consists of 100 M of single mode fiber, a grating pair dispersive delay line, and an interference filter as a tuning element.(Fig. 1) The pump source is a CW modelocked Nd:YAG laser emitting 80 psec pulses at 1064 nm. We observe pulses at the the first Raman stokes band (1100 nm) with pulsewidths as short as 0.8 psec. (Fig. 2)
Monitoring ligand-dependent assembly of receptor ternary complexes in live cells by BRETFect (2018)

There is currently an unmet need for versatile techniques to monitor the assembly and dynamics of ternary complexes in live cells. Here we describe bioluminescence resonance energy transfer with fluorescence enhancement by combined transfer (BRETFect), a high-throughput technique that enables robust spectrometric detection of ternary protein complexes based on increased energy transfer from a luciferase to a fluorescent acceptor in the presence of a fluorescent intermediate. Its unique donor-intermediate-acceptor relay system is designed so that the acceptor can receive energy either directly from the donor or indirectly via the intermediate in a combined transfer, taking advantage of the entire luciferase emission spectrum. BRETFect was used to study the ligand-dependent cofactor interaction properties of the estrogen receptors ERα and ERβ, which form homo- or heterodimers whose distinctive regulatory properties are difficult to dissect using traditional methods. BRETFect uncovered the relative capacities of hetero- vs. homodimers to recruit receptor-specific cofactors and regulatory proteins, and to interact with common cofactors in the presence of receptor-specific ligands. BRETFect was also used to follow the assembly of ternary complexes between the V2R vasopressin receptor and two different intracellular effectors, illustrating its use for dissection of ternary protein-protein interactions engaged by G protein-coupled receptors. Our results indicate that BRETFect represents a powerful and versatile technique to monitor the dynamics of ternary interactions within multimeric complexes in live cells.
Cooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis (2014)

GammaPNA oligomers having one or two repeats of the sequence AATCCC were designed to hybridize to DNA having one or more repeats of the complementary TTAGGG sequence found in the human telomere. UV melting curves and surface plasmon resonance experiments demonstrate high affinity and cooperativity for hybridization of these miniprobes to DNA having multiple complementary repeats. Fluorescence spectroscopy for Cy3-labeled miniprobes demonstrate increases in fluorescence intensity for assembling multiple short probes on a DNA target compared with fewer longer probes. The fluorescent γPNA miniprobes were then used to stain telomeres in metaphase chromosomes derived from U2OS cells possessing heterogeneous long telomeres and Jurkat cells harboring homogenous short telomeres. The miniprobes yielded comparable fluorescence intensity to a commercially available PNA 18mer probe in U2OS cells, but significantly brighter fluorescence was observed for telomeres in Jurkat cells. These results suggest that γPNA miniprobes can be effective telomere-staining reagents with applications toward analysis of critically short telomeres, which have been implicated in a range of human diseases.
Evaluation of an immunofluorescent-antibody test for rapid identification of Pseudomonas aeruginosa in blood cultures (1988)

An immunofluorescent-antibody test was developed for rapid detection of Pseudomonas aeruginosa in blood cultures. The test uses a murine monoclonal antibody specific for all strains of P. aeruginosa. In initial tests, bright uniform immunofluorescence signals were seen when each of the 17 international serotypes, as well as 14 additional isolates of P. aeruginosa, were examined. No immunofluorescent staining was observed when 37 other gram-negative and 15 gram-positive species were studied. In a clinical study, the assay was applied to broth smears of 86 gram-negative bacilli isolated from 74 bacteremic patients and 28 additional clinical isolates of Pseudomonas sp. and other oxidase-positive gram-negative bacilli recovered from various body sites. Smears were made directly from blood cultures which were positive for gram-negative bacilli by Gram staining. Eleven (15%) of 74 patients with gram-negative bacteremia had a positive test for P. aeruginosa. Including the results of these 11 isolates recovered in a prospective study and an additional 10 isolates from a retrospective study, we obtained a sensitivity and specificity of 100% (21 positive specimens and 103 negative specimens, respectively). These preliminary results suggest that this is a useful reagent for rapid presumptive identification of P. aeruginosa in blood cultures. With the immunofluorescent-antibody test, P. aeruginosa could be identified within 1 h of Gram stain evidence of gram-negative bacteremia.
A full-duplex ultrasonic through-wall communication and power delivery system (2013)

This paper presents a method for two-way ultrasonic communication and power delivery through thick metallic enclosures without physical penetration. Acoustic-electric channels are implemented using a pair of coaxially aligned piezoelectric transducers having 25.4 mm diameters and 1 MHz nominal resonant frequencies, mounted on steel walls having lengths in the range of 57.15 to 304.8 mm. A protocol is described which uses ultrasonic waves to achieve simultaneous bidirectional communication through the metallic enclosures. It is shown that such channels are very frequency selective, and a carrier frequency selection and tracking algorithm is presented to choose a frequency of operation at which both adequate power delivery and reliable full-duplex communication are achieved. Using this algorithm, sufficient power is harvested to allow for the continuous operation of internal electronics which require an aggregate of less than 100 mW. Reliable communication of sensor data is achieved at rates in excess of 30 kbps.
Susceptibility of <i>Streptococcus mutans </i>and <i>Streptococcus sobrinus</i> to Cell Wall Inhibitors and Development of a Novel Selective Medium for <i>S. sobrinus</i> (2002)

Representative strains of Streptococcus mutans and Streptococcus sobrinus showed differences in susceptibility to members of the monobactam group of beta-lactam antibiotics: S. sobrinus was less sensitive than S. mutans. The minimum inhibitory concentrations of aztreonam (AZT) and carumonam, both of which belong to this group, were 2,000 microg/ml for S. sobrinus and 125 microg/ml for S. mutans. Further addition of fosfomycin, bacitracin and sodium chloride to Mitis Salivarius agar (MS) supplemented with AZT resulted in growth inhibition of S. mutans and oral streptococci other than S. sobrinus, and was therefore used as a selective medium for S. sobrinus (MS-SOB medium). The average growth recovery of laboratory and clinically isolated strains of S. sobrinus on MS-SOB medium was 74.1% compared to that on MS medium. Seventy-eight percent of clinical samples in which S. sobrinus was detected yielded pure growth of S. sobrinus on MS-SOB medium.
Cable applications in robot compliant devices (1987)

Robotic systems need compliance to connect the robot to the work object. The cable system illustrated offers compliance for mating but can be changed in space to become quite stiff. Thus the same system can do both tasks, even in environments where the work object or robot are moving at different frequencies and different amplitudes. The adjustment can be made in all six degrees of freedom, translated in or rotated in any plane and still make a good contact and control.
Lineage-specific SNPs for genotyping of Mycobacterium tuberculosis clinical isolates (2017)

Tuberculosis (TB) is a severe infectious disease worldwide. Genetic variation of the causative agent, Mycobacterium tuberculosis (MTB), determines the outcomes of infection and anti-TB treatment. Until recently, there has been no effective and convenient way for classifying clinical isolates based on the DNA sequences of the divergent lineages of MTB infecting human populations. Here, we identified single nucleotide polymorphisms (SNPs) of six representative strains from Taiwan by whole-genome sequencing and comparing the results to the sequence of the H37Rv reference strain. One hundred and ten SNPs, each unique to one of the six strains, were used to genotype 150 additional isolates by applying DNA mass spectrometry. Lineage-specific SNPs were identified that could distinguish the major lineages of the clinical isolates. A subset including 32 SNPs was found to be sufficient to type four major groups of MTB isolates in Taiwan (ancient Beijing, modern Beijing, East African-Indian, and Latin-American Mediterranean). However, there was high genetic homozygosity within the Euro-American lineage, which included spoligotype-classified Haarlem and T strains. By whole-genome sequencing of 12 representative Euro-American isolates, we identified multiple subtype-specific SNPs which allowed us to distinguish two major branches within the Euro-American lineage.
Benchmark of a large scale database for facial beauty prediction (2016)

Due to its indefinite evaluation criterion, facial beauty analysis has shown its challenges in pattern recognition and biometric recognition. Plenty of methods have been designed for solving this problem, but there are still various limitations. Most of the available research results in this field are achieved on a small-scale facial beauty database which is difficult in modeling the structure information for facial beauty. And majority of the presented facial beauty prediction algorithm requires burden landmark or expensive optimization procedure. In this paper, we have established a large scale facial beauty database named LSFBD, which is a new database for facial beauty analysis. The LSFBD database contains 20000 labeled images, which has 10000 unconstrained male subjects and 10000 unconstrained female subjects separately, and all images are verified with well-designed rating with average scores and standard deviation. In this database, manually adding the extreme beauty images make the distribution more reasonable and the result more accurate. CRBM or Eigenfaces results are presented in the paper as benchmark for evaluating the task of facial beauty prediction.
Superlattice barrier infrared detector development at the Jet Propulsion Laboratory (2011)

We report recent efforts in achieving state-of-the-art performance in type-II superlattice based infrared photodetectors using the barrier infrared detector architecture. We used photoluminescence measurements for evaluating detector material and studied the influence of the material quality on the intensity of the photoluminescence. We performed direct noise measurements of the superlattice detectors and demonstrated that while intrinsic 1/<i>f</i> noise is absent in superlattice heterodiode, side-wall leakage current can become a source of strong frequency-dependent noise. We developed an effective dry etching process for these complex antimonide-based superlattices that enabled us to fabricate single pixel devices as well as large format focal plane arrays. We describe the demonstration of a 1024×1024 pixel long-wavelength infrared focal plane array based the complementary barrier infrared detector (CBIRD) design. An 11.5 μm cutoff focal plane without anti-reflection coating has yielded noise equivalent differential temperature of 53 mK at operating temperature of 80 K, with 300 K background and cold-stop. Imaging results from a recent 10 μm cutoff focal plane array are also presented.
Identification of a Novel SNF2/SWI2 Protein Family Member, SRCAP, Which Interacts with CREB-binding Protein (1999)

The ability of cAMP response-element binding protein (CREB)-binding protein (CBP) to function as a co-activator for a number of transcription factors appears to be mediated by its ability to act as a histone acetyltransferase and through its interaction with a number of other proteins (general transcription factors, histone acetyltransferases, and other co-activators). Here we report that CBP also interacts with a novel ATPase termed Snf2-Related CBP Activator Protein (SRCAP). Consistent with this activity, SRCAP contains the conserved ATPase domain found within members of the Snf2 family. Transfection experiments demonstrate that SRCAP is able to activate transcription when expressed as a Gal-SRCAP chimera and that SRCAP also enhances the ability of CBP to activate transcription. The adenoviral protein E1A was found to disrupt interaction between SRCAP and CBP possibly representing a mechanism for E1A-mediated transcriptional repression.
Abstract 3976: Targeted delivery of a synthetic microRNA-based mimic as an approach to cancer therapy (2015)

Abstract MicroRNA expression is commonly suppressed in cancer, contributing to tumor cell biology. Recently we demonstrated that multiple members of the miR-15/16 family are downregulated and have tumor suppressor functions in malignant pleural mesothelioma (MPM), an asbestos-related cancer for which few treatments are available. These results are similar to previous findings in prostate and non-small cell lung cancer (NSCLC). Using mimics to restore levels of miR 15a, miR-15b or miR-16 led to growth inhibition and induction of apoptosis of MPM cells in vitro. The miR-16 mimic, packaged in bacterially-derived, EGFR antibody-targeted, EDV(TM)nanocells, inhibited xenograft tumor growth in vivo. As multiple microRNAs from the same family are downregulated in MPM, we investigated whether a single synthetic mimic based on the consensus sequence of all family members could restore activity of the entire family. To this end we generated four novel mimics derived from the consensus sequence of the miR-15/16 family and tested them in a range of tumor cell lines. Compared with a mimic corresponding in sequence to native miR-16, the consensus mimics had enhanced growth inhibitory activity in MPM, NSCLC and prostate cancer lines, three tumor types in which miR-15/16 expression is suppressed. They were also active in cell lines derived from breast and colon cancer. When packaged in minicells, the synthetic mimics inhibited growth of MPM xenograft tumors in vivo. Based on these preclinical studies a Phase I clinical trial has been initiated for patients with MPM or NSCLC failing standard therapy. This represents only the second trial of microRNA replacement as a cancer therapy, and the first for thoracic cancer. Citation Format: Glen Reid, Marissa Williams, Michaela B. Kirschner, Nancy Mugridge, Jocelyn Weiss, Himanshu Brahmbhatt, Jennifer MacDiarmid, Nico van Zandwijk. Targeted delivery of a synthetic microRNA-based mimic as an approach to cancer therapy. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3976. doi:10.1158/1538-7445.AM2015-3976
Vertical Enhancement-Mode InAs Nanowire Field-Effect Transistor With 50-nm Wrap Gate (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We present results on fabrication and dc characterization of vertical InAs nanowire wrap-gate field-effect transistor arrays with a gate length of 50 nm. The wrap gate is defined by evaporation of 50-nm Cr onto a 10-nm-thick <formula formulatype="inline"><tex>$\hbox{HfO}_{2}$</tex></formula> gate dielectric, where the gate is also separated from the source contact with a 100-nm <formula formulatype="inline"><tex>$\hbox{SiO}_{x}$</tex> </formula> spacer layer. For a drain voltage of 0.5 V, we observe a normalized transconductance of 0.5 S/mm, a subthreshold slope around 90 mV/dec, and a threshold voltage just above 0 V. The highest observed normalized on current is 0.2 A/mm, with an off current of 0.2 mA/mm. These devices show a considerable improvement compared to previously reported vertical InAs devices with <formula formulatype="inline"><tex>$\hbox{SiN}_{x}$</tex></formula> gate dielectrics. </para>
A Low-Profile Third-Order Bandpass Frequency Selective Surface (2009)

We demonstrate a new class of low-profile frequency selective surfaces (FSS) with an overall thickness of lambda/24 and a third-order bandpass frequency response. The proposed FSS is a three layer structure composed of three metal layers, separated by two electrically thin dielectric substrates. Each layer is a two-dimensional periodic structure with sub-wavelength unit cell dimensions and periodicity. The unit cell of the proposed FSS is composed of a combination of resonant and non-resonant elements. It is shown that this arrangement acts as a spatial bandpass filter with a third-order bandpass response. However, unlike traditional third-order bandpass FSSs, which are usually obtained by cascading three identical first-order bandpass FSSs a quarter wavelength apart from one another and have thicknesses in the order of lambda/2 , the proposed structure has an extremely low profile and an overall thickness of about lambda/24 , making it an attractive choice for conformal FSS applications. As a result of the miniaturized unit cells and the extremely small overall thickness of the structure, the proposed FSS has a reduced sensitivity to the angle of incidence of the EM wave compared to traditional third-order frequency selective surfaces. The principles of operation along with guidelines for the design of the proposed FSS are presented in this paper. A prototype of the proposed third-order bandpass FSS is also fabricated and tested using a free space measurement system at C band.
Evaluation of the flatness effects of mask backing and orientation during photomask pellicle mount (2009)

As technology advances, the demand for tighter photomask final flatness specifications becomes greater. Studies have shown that the process of mounting a pellicle induces the largest change in flatness in photomask fabrication. Photomask pellicles play an important role in flatness due to the many components in the mounting process. For example, pellicle frame flatness, pellicle adhesive, mounting force, mounting time, mounting orientation and mask backing shape during mount all can play a role in changing the mask shape during pellicle mount. Many of these factors have been investigated over the last several years [1][2][3][4]. Recent studies have demonstrated that the height of the pellicle frame also has a significant impact on the final flatness with lower stand off frames resulting in reduced pellicle influence on mask distortion [5]. This paper will examine the flatness influence factor as a function of mounting direction and mask backing variations. For these experiments, the same pellicle frame was remounted for each set of experiments to eliminate external pellicle frame flatness factors and to minimize the amount of data deviations. Four different types of mask backing types were selected that differed in the contact area with the mask in particular pressure points. The mask backing types consist of a border frame, 4 point pressure points, a full backing plate (quartz substrate), and a pellicle frame. In addition to using the four different types of mask backings, the pellicles were also mounted both in the vertical and horizontal directions in determining final photomask flatness. This work demonstrates that frame flatness and shape play the largest roles and mounting force, backing plate and mounting orientation have less of an effect.
Bidirectional relaying protocol & power allocation scheme for cognitive buffer-aided DF relay networks (2017)

In this paper, we consider bidirectional decode-and-forward (DF) buffer-aided relay selection and transmission power allocation schemes for underlay cognitive radio (CR) relay networks. First, a low complexity delay-constrained bidirectional relaying protocol is proposed. The proposed protocol maximizes the single-hop normalized sum of the primary network (PN) and secondary network (SN) rates and controls the maximum packet delay caused by physical layer buffering at relays. Second, optimal transmission power expressions that maximize the single-hop normalized sum rate are derived for each possible transmission mode. Additionally, the impacts of several system parameters including maximum buffer size, interference threshold, maximum packet delay and number of relays on the network performance are also investigated. The results reveal that the proposed bidirectional relaying protocol and antenna transmission power allocation schemes introduce a satisfactory performance with much lower complexity compared to the optimal relay selection and power allocation schemes and provide an application dependent delay-controlling mechanism. It is also found that the network performance degrades as the delay constraint is more restricted until it matches the performance of conventional unbuffered relaying with delay constraints of three. Additionally, findings show that using buffer-aided relaying significantly enhances the SN performance while slightly weakens the performance of the PN.
Narrow-band, band-pass filters with zig-zag, hairpin-comb resonators (2003)

"Hairpin-comb" filters have been previously shown to have special properties which are advantageous for the design of compact, narrow-band, band-pass microstrip filters. Herein, a new "zig-zag" form of hairpin-comb filter is introduced which is shown to have additional important advantages for designing compact narrow-band filters. Examples with computed and measured results are presented.