gebhart/patrepeval huggingface dataset:
Distributed Turbo Coding With Soft Information Relaying in Multihop Relay Networks (2006)

It has been shown that distributed turbo coding (DTC) can approach the capacity of a wireless relay network. In the existing DTC schemes, it is usually assumed that error-free decoding is performed at a relay. We refer to this type of DTC schemes as perfect DTC. In this paper, we propose a novel DTC scheme. For the proposed scheme, instead of making a decision on the transmitted information symbols at the relay as in perfect DTC, we calculate and forward the corresponding soft information. We derive parity symbol soft estimates for the interleaved source information when only the a posteriori probabilities of the information symbols are known. The results show that the proposed scheme can effectively mitigate error propagation due to erroneous decoding at the relay. Simulation results also confirm that the proposed scheme approaches the outage probability bound of a distributed two-hop relay network at high signal-to-noise ratios
Practical approaches to channel estimation and interference suppression for OFDM based UWB communications (2004)

Ultra-wideband (UWB) communication is a potential technique for future high-speed networks. In this paper, we investigate low complexity signal detection approaches for OFDM based UWB systems. In particular, we develop practical approaches for channel estimation and interference suppression. Computer simulation results show that these techniques can be effectively used in OFDM based UWB systems for performance improvement.
Complex Formation between Magnesocene (MgCp<sub>2</sub>) and NH<sub>3</sub>:  Implications for p-Type Doping of Group III Nitrides and the Mg Memory Effect (2004)

Magnesocene (biscyclopentadienylmagnesium) is a common precursor used for the p-type doping of GaN and other group III nitride materials. Unfortunately, difficulties remain with predictably controlling the incorporation of Mg during metal organic chemical vapor deposition (MOCVD) film growth, which often exhibits poorly understood “memory effects.” Although the formation of a reaction product between magnesocene and ammonia has been previously speculated, one has never been experimentally isolated or identified. We have spectroscopically observed and identified, for the first time, the adducts formed between magnesocene and ammonia. Density functional theory (DFT) quantum chemistry calculations have also been performed on the system to determine the structures and energetics of the reaction products. It was found that ammonia can form condensable Lewis acid−base complexes with magnesocene in both 1:1 and 2:1 ratios (i.e., NH3−MgCp2 and (NH3)2−MgCp2) via nucleophilic attack of NH3 at the positively charged Mg center of MgCp2. Adduct formation is reversible, and the 1:1 and 2:1 products can be converted to one another by controlling the NH3 partial pressure. The formation and condensation of both adducts at room temperature is the probable parasitic source that leads to many of the observed Mg incorporation difficulties during the p-type doping of group III nitride materials.
Associating structured records to text documents (2012)

Postulate two independently created data sources. The first contains text documents, each discussing one or a small number of objects. The second is a collection of structured records, each containing information about the characteristics of some objects. We present techniques for associating structured records to corresponding text documents and empirical results supporting the proposed techniques.
Non-Premixed and Premixed Colorless Distributed Combustion for Gas Turbine Application (2010)

Non-premixed and premixed modes of Colorless Distributed Combustion (CDC) are investigated for application to gas turbine combustors. The CDC provides significant improvement in pattern factor, reduced NOx emission uniform thermal field in the entire combustion zone for it to be called as a isothermal reactor, and lower sound levels. Basic requirement for CDC is mixture preparation through good mixing between the combustion air and product gases so that the reactants are at much higher temperature to result in hot and diluted oxidant stream at temperatures that are high enough to auto-ignite the fuel and oxidant mixture. With desirable conditions one can achieve spontaneous ignition of the fuel with distributed combustion reactions. Distributed reactions can also be achieved in premixed mode of operation with sufficient entrainment of burned gases and faster turbulent mixing between the reactants. In the present investigation two non-premixed combustion modes and one premixed combustion mode that provide potential for CDC is examined. In all the configurations the air injection port is positioned at the opposite end of the combustor exit, whereas the location of fuel injection ports is changed to give different configurations. The results are compared for global flame signatures, exhaust emissions, acoustic signatures, and radical emissions using experiments and flow field, gas recirculation and mixing using numerical simulations. Ultra low NOx emissions are observed for both the premixed and non-premixed combustion modes, and almost colorless flames (no visible flame color) have been observed for the premixed combustion mode. The non-premixed mode was also provided near colorless distributed combustion. The reaction zone is observed to be significantly different in the two non-premixed modes.
MgO /p- GaN enhancement mode metal-oxide semiconductor field-effect transistors (2004)

We report the initial demonstration of an enhancement mode MgO/p-GaN metal-oxide-semiconductor field-effect transistor (MOSFET) utilizing Si+ ion-implanted regions under the source and drain to provide a source of minority carriers for inversion. The breakdown voltage for an 80-nm-thick MgO gate dielectric was ∼14 V, corresponding to a breakdown field strength of 1.75 MV cm−1 and the p-n junction formed between the p-epi and the source had a reverse breakdown voltage &gt;15 V. Inversion of the channel was achieved for gate voltages above 6 V. The maximum transconductance was 5.4 μS mm−1 at a drain-source voltage of 5 V, comparable to the initial values reported for GaAs MOSFETs.
Baseline hepatitis B core antibody predicts treatment response in chronic hepatitis B patients receiving long‐term entecavir (2016)

Studies regarding the clinical significance of quantitative hepatitis B core antibody (anti-HBc) in patients with chronic hepatitis B receiving first-line nucleos(t)ide analogues is limited. The aim of this study was to determine the performance of anti-HBc as a predictor for hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive CHB patients treated with entecavir. This was a retrospective cohort study consisting of 139 Chinese patients enrolled in a multicenter clinical trial treated with entecavir or entecavir maleate for up to 240 weeks. Anti-HBc evaluation was conducted for all the available samples using a newly developed double-sandwich anti-HBc immunoassay. At week 240, 35 (25.2%) patients achieved a serological response (HBeAg seroconversion) and these patients at week 240 had significantly higher levels of anti-HBc (P<.01). We defined 4.65 log<sub>10</sub> IU·mL<sup>-1</sup> , with a maximum sum of sensitivity and specificity, as the optimal cut-off value of baseline anti-HBc level to predict seroconversion. Patients with baseline anti-HBc ≥4.65 log<sub>10</sub> IU·mL<sup>-1</sup> had 28.0% (26/93) and 35.5% (33/93) chance of seroconversion at weeks 144 and 240, respectively. The baseline anti-HBc level was the strongest predictor for seroconversion at week 144 (OR: 5.78, 95% confidence interval [CI]: 2.05-16.34, P=.001). The baseline anti-HBc level was a strong predictor for seroconversion at week 240 (OR: 5.36, 95% CI: 2.17-13.25, P<.001). Hence, baseline anti-HBc titre is a useful predictor of long-term entecavir therapy efficacy in HBeAg-positive CHB patients, which could be used to optimize antiviral therapy.
<title>Fully self-consistent nonlinear theory of energy and current modulation in relativistic klystron amplifiers</title> (1992)

A self-consistent nonlinear theory of the energy and current modulation in a relativistic electron beam propagating through a klystron amplifier is developed. A closed integro- differential equation for the beam current is obtained, assuming that the beam current is a function of time t and propagation distance z. Properties of the current and energy modulation are investigated from this integro- differential equation for a broad range of system parameters. Magnitudes of the energy and current modulation are determined in terms of the gap voltage, the microwave frequency, geometrical configuration, the beam intensity and initial kinetic energy of the beam. The modulation amplitude increases, reaches peak and decreases slowly, as the beam propagates through the amplifier. The theory is extended to a two-cavity klystron and it is shown that the theoretical results agree remarkably well with previous simulation data.
Fabry-Perot diaphragm fiber-optic sensor (2007)

The general theory of a diaphragm fiber-optic sensor (DFOS) is proposed. We use a critical test to determine if a DFOS is based on Fabry-Perot interference or intensity modulation. By use of the critical test, this is the first design, to the best of our knowledge, of a purely Fabry-Perot DFOS, fabricated with microelectromechanical system technology, and characterized as an audible microphone and ultrasonic hydrophone with orders of improvement in signal-to-noise ratio.
Dynamic auctions in procurement (2006)

Procurements for many related items are commonplace. Dynamic auctions have many advantages in such environments. We consider both the purchase of many related items and the purchase of many divisible goods, such as energy products or environmental allowances, or other procurement contracts. In such auctions, the bids specify quantities of each of the items: the megawatt-hours of electricity or the tons of emissions. Often, related goods are – or could be – auctioned at the same time. In electricity markets, products with several durations or locations may be auctioned together. In environmental auctions, emission reductions for each of several different pollutants or time periods may be bought at the same time. This chapter explores how procurement auctions for many divisible or indivisible goods should be conducted. Of course, the answer depends on the objective of the buyer and the bidding environment. Here we focus on a few of the important issues of auction design in a setting where the buyer cares about some combination of efficiency (procuring the goods from the lowest-cost suppliers) and minimization of the payment for purchasing the goods. Our purpose is to motivate a sensible design in a realistic environment, rather than to prove the optimality of a particular design, which would require more restrictive assumptions than we care to make.
Waveguide-Integrated Ge p-i-n Photodetectors on SOI Platform (2006)

We demonstrate a fully CMOS processed Ge p-i-n photodetector integrated with a Si waveguide on a SOI platform with a high responsivity of 1.0 A/W at lambda=1520 nm, and a 3 dB bandwidth of >4.5 GHz measured at lambda=1550 nm
Single-molecule electronic detection using nanoscale field-effect devices (2011)

Traditionally, biomolecular systems have been studied in ensemble. While much can be determined with ensemble measurements, scientific and technological interest is rapidly moving to single-molecule techniques, which rely primarily on fluorescent markers and advanced microscopy techniques. In this paper, we describe recent work using nanoscale transistors based on carbon nanotubes as charge-sensitive detectors. We show carbon nanotubes can be used for ensemble studies through sidewall adsorption. Sensitivity can be greatly enhanced though an engineered defect in the nanotube. Biomolecular interactions are characterized by random-telegraph-noise response, which can be analyzed to study single-molecule kinetics and thermodynamics.
Current Advances in the Application of Raman Spectroscopy for Molecular Diagnosis of Cervical Cancer (2015)

Raman spectroscopy provides a unique biochemical fingerprint capable of identifying and characterizing the structure of molecules, cells, and tissues. In cervical cancer, it is acknowledged as a promising biochemical tool due to its ability to detect premalignancy and early malignancy stages. This review summarizes the key research in the area and the evidence compiled is very encouraging for ongoing and further research. In addition to the diagnostic potential, promising results for HPV detection and monitoring treatment response suggest more than just a diagnosis prospective. A greater body of evidence is however necessary before Raman spectroscopy is fully validated for clinical use and larger comprehensive studies are required to fully establish the role of Raman spectroscopy in the molecular diagnostics of cervical cancer.
Reverse transcriptases from bacterial retrons require specific secondary structures at the 5'-end of the template for the cDNA priming reaction. (1993)

Multicopy single-stranded DNA (msDNA) is a peculiar molecule consisting of a single-stranded DNA that is branched out from an internal G residue of an RNA molecule (msdRNA) via a 2',5'-phosphodiester linkage. The genetic unit required for msDNA synthesis is designated "retron" and consists of msr (a gene for msdRNA), msd (a gene for msDNA), and a gene for reverse transcriptase (RT) in a single operon. To date, four different msDNAs have been isolated from Escherichia coli. They do not share any primary sequences in either RNA or DNA. To elucidate the specificity of bacterial RT for msDNA synthesis, the msr-msd region from retron-Ec67 was introduced into E. coli cells producing RT-Ec73, or the msr-msd region from retron-Ec73 into E. coli cells producing RT-Ec67. In both cases, msDNA was not synthesized. However, when the msdRNA coding regions (msr) for retron-Ec67 and -Ec73 were mutually exchanged and the chimeric genes were introduced into E. coli cells producing either RT-Ec67 or RT-Ec73, it was thus found that msDNA was produced only when msr and RT were from the same retron. Requirement of the msr region for msDNA synthesis by RT was further investigated by mutations in the msr region for retron-Ec67. These analyses revealed that there is a strict requirement for specific primary sequences as well as the secondary structure in msdRNA. This finding is discussed in relationship to the mechanism of the priming reaction of cDNA synthesis by eukaryotic retroviral RTs using tRNAs.
Detection of C, H, N, and O in capillary gas chromatography by atomic emission (1989)

Abstract Using a new atomic emission detector for gas chromatography, the quantitative and qualitative aspects of selective elemental detection of carbon, hydrogen, nitrogen, and oxygen were investigated. Sensitivity, precision, degree of tailing, and response variation between compounds are reported for capillary applications. Earlier atomic emission detectors reported poor sensitivity and selectivity for the analysis of oxygen. These problems have been greatly reduced due to lower interactions between elements in the sample and the silica wall of the water‐cooled discharge tube. Using near‐optimal sample amounts and chromatographic conditions, area precision was found to be very good with little variation in response factors among different compounds. For the compounds tested, response factors varied over a span of 2% to 3% for carbon, hydrogen, and nitrogen, and over 7% for oxygen. For quantitative analysis, area ratios were calibrated directly from the area ratios of two elements of an internal standard, and yielded better precision and compound independence than the individual calibrated response of each element. Empirical formulas were calcualted using one peak as a qualitative internal standard. Unambiguous formulas were determined for some, but not all, of the compounds tested. Further increases in precision and/or compound independence is needed before empirical formula determination can be used as a routine tool.
Synthesis of High Quality Phosphorothioate Oligonucleotides as Antisense Drugs. Use of I‐Linker in the Elimination of 3′‐Terminal Phosphorothioate Monoesters (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Discovery Proteomics and Nonparametric Modeling Pipeline in the Development of a Candidate Biomarker Panel for Dengue Hemorrhagic Fever (2012)

Secondary dengue viral infection can produce capillary leakage associated with increased mortality known as dengue hemorrhagic fever (DHF). Because the mortality of DHF can be reduced by early detection and intensive support, improved methods for its detection are needed. We applied multidimensional protein profiling to predict outcomes in a prospective dengue surveillance study in South America. Plasma samples taken from initial clinical presentation of acute dengue infection were subjected to proteomics analyses using ELISA and a recently developed biofluid analysis platform. Demographics, clinical laboratory measurements, nine cytokines, and 419 plasma proteins collected at the time of initial presentation were compared between the DF and DHF outcomes. Here, the subject's gender, clinical parameters, two cytokines, and 42 proteins discriminated between the outcomes. These factors were reduced by multivariate adaptive regression splines (MARS) that a highly accurate classification model based on eight discriminant features with an area under the receiver operator curve (AUC) of 0.999. Model analysis indicated that the feature-outcome relationship were nonlinear. Although this DHF risk model will need validation in a larger cohort, we conclude that approaches to develop predictive biomarker models for disease outcome will need to incorporate nonparametric modeling approaches.
Optimizing close-down processes of single-robot cluster tools via linear programing (2016)

In a cluster tool, periodical maintenance and lot switching operations require that the tool should be emptied from time to time. Thus, it is very important to optimize a normal close-down process from the steady state to the idle state. Besides, process modules (PMs) are prone to failure. When a PM at a step without any other parallel PMs fails, the tool cannot complete the entire process of any new wafer and some already in the tool. We need to close down the tool to empty it as well. Optimal scheduling of a close-down process is important yet challenging. Wafer residency time constraints make it even more challenging. By assuming no parallel PM at a step, this work focuses on time-constrained single-arm cluster tools in order to optimize their close-down process with and without PM failure. It first develops a linear program to optimize a normal close-down process. It then presents PM failure control rules to deal with the wafer in a failed PM and develops one more linear program to find an optimal schedule for the close-down process with PM failure. This work finally gives a real industrial case to show the new research results.
Surface-Charge-Dependent Cell Localization and Cytotoxicity of Cerium Oxide Nanoparticles (2010)

Cerium oxide nanoparticles (nanoceria) have shown great potential as antioxidant and radioprotective agents for applications in cancer therapy. Recently, various polymer-coated nanoceria preparations have been developed to improve their aqueous solubility and allow for surface functionalization of these nanoparticles. However, the interaction of polymer-coated nanoceria with cells, their uptake mechanism, and subcellular localization are poorly understood. Herein, we engineered polymer-coated cerium oxide nanoparticles with different surface charges (positive, negative, and neutral) and studied their internalization and toxicity in normal and cancer cell lines. The results showed that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g., cytoplasm and lysosomes) depending on the nanoparticle's surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticles' cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cells. In contrast, minimal toxicity is observed when they localize into the cytoplasm or do not enter the cells. Taken together, these results indicate that the differential surface-charge-dependent localization of nanoceria in normal and cancer cells plays a critical role in the nanoparticles' toxicity profile.
Binding characteristics of antibodies to the TSH receptor (1998)

We have used fragments of the TSH receptor (TSHR) expressed in E. coli as glutathione S-transferase fusion proteins to produce rabbit polyclonal antibodies and a panel (n=5) of monoclonal antibodies to the extracellular fragment of the TSHR. The binding characteristics of the antibodies to linear, conformational, glycosylated and unglycosylated forms of the receptor in different assay systems have been investigated. The reactivity of these antibodies with the TSHR was assessed by Western blotting with both native and recombinant human TSHR expressed in CHO cells, immunoprecipitation of 35S-labelled full-length TSHR produced in an in vitro transcription/ translation system, immunoprecipitation of 125I-TSH/TSHR complexes, inhibition of 125I-TSH binding to the TSHR and fluorescence activated cell sorter (FACS) analysis of binding to CHO-K1 cells expressing the TSHR on their cell surface. Fab fragments of monoclonal antibodies were isolated, labelled with 125I and used to determine the affinity constants of these antibodies with receptor, bound and free Fab being separated by polyethylene glycol (PEG) precipitation. Rabbit polyclonal and mouse monoclonal antibodies reacted with the TSHR in Western blotting and one monoclonal antibody (3C7) was able to inhibit 125I-TSH binding to native human TSHR (74% inhibition), recombinant human TSHR (84% inhibition) and porcine TSHR (65% inhibition). Affinity constant values for TSHR monoclonal antibody Fab fragments calculated using Scatchard analysis were about 10(7) M(-1). Four out of five monoclonal antibodies reacted in FACS analysis with TSHR expressed on the surface of CHO-K1 cells. The FACS unreactive monoclonal (3C7) bound well to detergent solubilised TSH receptors and this emphasised the importance of using a combination of FACS analysis and radioactively-labelled probes in analysis of the TSH receptor. The monoclonal antibodies produced in this study were found to be of relatively low affinity but proved useful for detection of the receptor by Western blotting and by FACS analysis.