gebhart/patrepeval huggingface dataset:
Alterations in polyamine metabolism during continuous intravenous infusion of alpha-difluoromethylornithine showing correlation of thrombocytopenia with alpha-difluoromethylornithine plasma levels. (1989)

Polyamine biosynthesis is important for cell proliferation and growth. The purpose of this study was to determine the biochemical and pharmacological parameters associated with host toxicity from a continuous infusion of alpha-difluoromethylornithine (DFMO). Twenty-five patients with metastatic carcinoma of the colon or rectum received continuous infusion of DFMO at a median dose of 8 g/m2/day (range, 6-14) for 28 days. DFMO plasma levels, RBC, plasma putrescine, spermidine, and spermine levels, and patient toxicities were evaluated. There was a significant decrease in RBC and plasma levels of putrescine, spermidine, and spermine following DFMO administration compared with the baseline RBC and plasma levels. Pearson correlation coefficient comparing nadir platelet count and steady-state DFMO level was statistically significant (n = 37; P less than 0.01; r = -0.53). Sustained suppression of circulating polyamine levels was also achieved with continuous DFMO infusion. The correlation between steady-state plasma DFMO levels and lowering of platelet count warrants prospective evaluation to determine its clinical usefulness.
Optically Active α‐Chloro‐(<i>E</i>)‐crotylboronate Esters by Allyl Rearrangement (1986)

Good chirality transfer to anti-homoallyl alcohol 3 is observed in the addition of the chiral α-chlorocrotylboronate 2 to aldehydes. The title reaction 1 → 2 is effected by SOCl2.
Topographical Distribution of Spindles and K-complexes in Normal Subjects (1997)

To assess the topographical distribution of sleep spindles and K-complexes, four 15-minute samples of stage 2 sleep in a group of eight healthy young adults were analyzed. Results show that a majority of spindles generated are detected over central regions, and that K-complexes are markedly predominant over prefrontal and frontal regions. These findings are consistent with the single-spindle generator hypothesis and raise questions concerning the Rechtschaffen and Kales rules for scoring K-complexes.
Intelligent Job Matching with Self-learning Recommendation Engine (2015)

Most of the job matching engine today only takes into consideration with the information directly extracted from the resumes and vacancies. The two set of information match against each other based on some predefined rules. This paper presents the methodologies to perform job matching with user provided information, from now on referred to as parameters. A few common parameters for job matching includes domain of job, job title, position, knowledge, experience, location, salary and etc. Predefined rules assigning weighting factor to each parameter and defining how matching results could be filter and rank to produce job matching result. Besides, this paper also explained the methodologies used to auto-filling in places where a candidate has missed out certain important information in their resume. The auto-filing utilized the self-learning engine to collect information, analysis the data and auto generates standard template for different categories group. The standard template is categorized based on some parameters such as qualification, education background and job experience. The self-learning engine uses the advantage of ontology to make inference from data in order to discover missing parameters as well as new relationship among the parameters. The inference techniques also improve the possible inconsistencies of various parameters. The system then performs a final job matching based on direct parameters extracted from user input and dynamically populated parameters from matched standard template.
Radiation Theory and the Quantum Revolution (1993)

Radiation theory the background top radiation theory the rise of spectroscopy the changing scenery Kirchhoff's law the background to quantum theory. Appendices: The Kirchhoff-Planck radiation law the structure of the quantum revolution quantum duality.
Blue phase liquid crystal: strategies for phase stabilization and device development (2015)

The blue phase liquid crystal (BPLC) is a highly ordered liquid crystal (LC) phase found very close to the LC-isotropic transition. The BPLC has demonstrated potential in next-generation display and photonic technology due to its exceptional properties such as sub-millisecond response time and wide viewing angle. However, BPLC is stable in a very small temperature range (0.5-1 °C) and its driving voltage is very high (∼100 V). To overcome these challenges recent research has focused on solutions which incorporate polymers or nanoparticles into the blue phase to widen the temperature range from around few °C to potentially more than 60 °C. In order to reduce the driving voltage, strategies have been attempted by modifying the device structure by introducing protrusion or corrugated electrodes and vertical field switching mechanism has been proposed. In this paper the effectiveness of the proposed solution will be discussed, in order to assess the potential of BPLC in display technology and beyond.
Detection of periodic signals in brain echo-planar functional images (2002)

In this paper, we propose to use signal autocorrelation values at specially selected delays in order to construct brain periodic activity images. In comparison to the usual approaches, our method requires very little a priori information about the real signal. We applied this method to a well-known vision paradigm. The images thus obtained revealed that the autocorrelation peak method discriminates better expected activated areas from background than the classical method based on correlation with an artificial waveform which may induce false detection.
Multifunctional coupling agents for living cationic polymerization. IV. Synthesis of end‐functionalized multiarmed poly(vinyl ethers) with multifunctional silyl enol ethers (1994)

Abstract Telechelic ( 8 ) and end‐functionalized four‐arm star polymers ( 9 ) were synthesized through the coupling reactions of end‐functionalized living poly(isobutyl vinyl ether) ( 5; DP n ∼ 10) with the bi‐and tetrafunctional silyl enol ethers, H 4‐ n C[CH 2 OC 6 H 4 C(OSiMe 3 ) = CH 2 ] n ( 3: n = 2; 4: n = 4). The precursor polymers 5 were prepared by living cationic polymerization with functionalized initiators, CH 3 CH(Cl)OCH 2 CH 2 X(6), in conjunction with zinc chloride in methylene chloride at −15°C. The initiators 6 were obtained by the addition of hydrogen chloride gas to vinyl ethers bearing pendant functional groups X , including acetoxy [OC(O)CH 3 ], styryl (OCH 2 C 6 H 4 ‐ p ‐CH = CH 2 ), and methacryloyl [OC(O)C(CH 3 ) = CH 2 ]. The coupling reactions with 3 and 4 in methylene chloride at −15°C for 24 h afforded the end‐functionalized multiarmed polymers ( 8 and 9 ) in high yield (>91%), where those with styryl or methacryloyl groups are new multifunctional macromonomers. © 1994 John Wiley & Sons, Inc.
Modeling the SARS Epidemic (2003)

Analyzing the transmission of SVCV among zebrafish populations by compartment mathematical modeling,
화학분석 : DNA '' Comet Assay '' 를 이용한 곡류의 방사선 조사 여부 확인 (1999)

저선량으로 조사된 곡류의 방사선 조사 여부를 판별 하는데 DNA `Comet Assay`의 활용이 가능한지를 검토하였다. 참깨, 들깨, 밀, 보리 및 쌀을 0, 0.1, 0.3, 0.5, 0.7, 1.0 kGy로 조사하여 시료로 사용하였다. 시료에 PBS 용액을 가하여 세포 현탁액을 조제하고 agarosegel과 혼합하여 microscope slide 상에서 lysis한 후 전기영동하여 염색한 다음 DNA 절편의 이동에 의해 형성된 ‘comet’의 tail length를 측정하여 분석하였다. 0.3 kGy 이상으로 조사한 모든 시료에서 tail length가 비조사한 시료와 차이를 나타내어 조사 여부를 확실히 판별할 수 있었다. 또한 비조사된 시료에서는 tail이 없거나 아주 짧은 tail을 가진 세포들이 관찰되었으며, 조사된 시료에서는 조사선량의 증가에 따라 DNA의 손상정도가 증가함으로서 tail length가 길어지는 것이 관찰되었다. 특히 참깨, 들깨 및 밀의 경우는 0.1 kGy의 낮은 조사선량에서도 현미경을 통하여 육안으로 비조사한 시료와의 구별이 가능하였다. 따라서 DNA `Comet Assay`는 간단하고 신속하며 비교적 저렴하게 실시할 수 있는 곡류의 방사선 조사 여부를 판별하는 데 활용할 수 있음을 확인하였다.
Visualization and enrichment of live putative cancer stem cell populations following p53 inactivation or Bax deletion using non-toxic fluorescent dyes (2009)

Putative cancer stem cell (CSC) populations efflux dyes such as Hoechst 33342 giving rise to side populations (SP) that can be analyzed or isolated by flow cytometry. However, Hoechst 33342 is highly toxic, more so to non-SP cells, and thus presents difficulties in interpreting in vivo studies where non-SP cells appear less tumorigenic than SP cells in immunodeficient mice. We searched for non-toxic dyes to circumvent this problem as well as to image these putative CSCs. We found that the fluorescent dye calcein, a product of intracellular Calcein AM cleavage, is effluxed by a small subpopulation, calcein low population (C(lo)P). This population overlaps with SP and demonstrated long term cell viability, lack of cell stress and proliferation in several cancer cell lines when stained whereas Hoechst 33342 staining caused substantial apoptosis and ablated proliferation. We also found that the effluxed dye D-luciferin exhibits strong UV-fluorescence that can be imaged at cellular resolution and spatially overlaps with Calcein AM. In order to evaluate the hypothesis that p53 loss promotes enrichment of putative CSC populations we used Calcein AM, D-luciferin and Mitotracker Red FM as a counterstain to visualize dye-effluxing cells. Using fluorescence microscopy and flow cytometry we observed increased dye-effluxing populations in DLD-1 colon tumor cells with mutant p53 versus wild-type (WT) p53-expressing HCT116 cells. Deletion of the wild-type p53 or pro-apoptotic Bax genes induced the putative CSC populations in the HCT116 background to significant levels. Restoration of WT p53 in HCT116 p53(-/-) cells by an adenovirus vector eliminated the putative CSC populations whereas a control adenovirus vector, Ad-LacZ, maintained the putative CSC population. Our results suggest it is possible to image and quantitatively analyze putative CSC populations within the tumor microenvironment and that loss of pro-apoptotic and tumor suppressing genes such as Bax or p53 enrich such tumor-prone populations.
Synthesis and biological activity of new potential antimalarial: 1H-pyrazolo[3,4-b]pyridine derivatives. (2000)

The appearance of drug resistant Plasmodium falciparum malaria necessitates the search for novel antimalarial agents. Using the classical ring-bioisosterism concept as a strategy to develop new potential drugs, 1H-pyrazolo[3,4-b]pyridine 4-aminomethanol compounds were designed and synthesized as isosteres of the classical quinoline antimalarial mefloquine. The hydrochloride form of these compounds were tested for in vitro antimalarial activity against chloroquine-sensitive (Sierra Leone D-6) and resistant (Indochina W-2) clones of P. falciparum. The results described herein indicated that 1-H-pyrazolo[3,4-b]pyridine system represents a bioisosteric framework to quinoline system in the antimalarial activity.
Metal-Based Compounds in Antiviral Therapy (2022)

In recent years, the study of metal complexes and metal-based nanomaterials has aroused particular interest, leading to the promotion of new effective systems for the abatement of various viral diseases. Starting from the analysis of chemical properties, this review focuses on the employment of metal-based nanoparticles as antiviral drugs and how this interaction leads to a substantial enhancement in antiviral activity. The use of metal-based antiviral drugs has also spread for the formulation of antiviral vaccines, thanks especially to the remarkable adjuvant activities of some of the metal complexes. In particular, the small size and inert nature of Au- and Ag-based nanoparticles have been exploited for the design of systems for antiviral drug delivery, leading to the development of specific and safe therapies that lead to a decrease in side effects.
A ridesharing simulation platform that considers dynamic supply-demand interactions (2021)

This paper presents a new ridesharing simulation platform that accounts for dynamic driver supply and passenger demand, and complex interactions between drivers and passengers. The proposed simulation platform explicitly considers driver and passenger acceptance/rejection on the matching options, and cancellation before/after being matched. New simulation events, procedures and modules have been developed to handle these realistic interactions. The capabilities of the simulation platform are illustrated using numerical experiments. The experiments confirm the importance of considering supply and demand interactions and provide new insights to ridesharing operations. Results show that increase of driver supply does not always increase matching option accept rate, and larger matching window could have negative impacts on overall ridesharing success rate. These results emphasize the importance of a careful planning of a ridesharing system.
A scatter and randoms weighted (SRW) iterative PET reconstruction (2011)

The authors have developed a practical scatter and randoms weighting scheme in the sensitivity image for iterative PET reconstructions. Our proposed SRW method has a number of advantages over the conventional methods, and it has shown promising results with additional optimization for various applications to be further investigated.
A Division-Linked Mechanism for the Rapid Generation of Ig-Secreting Cells from Human Memory B Cells (2003)

Memory B cells, when re-exposed to Ag and T cell help, differentiate into Ig-secreting cells (ISC) at the same time as maintaining a residual pool of non-Ig-secreting cells with memory capabilities. To investigate the mechanism underlying this dual process, we followed the fate of human B cells activated in vitro with the T cell-derived signals CD40 ligand (CD40L), IL-2, and IL-10 using CFSE to monitor cell division. A substantial number of ISCs detected by ELISPOT, intracellular Ig staining, and Ig secretion could be generated from memory but not naive B cells. The proportion of ISCs increased with successive cell divisions and was markedly enhanced by IL-10 at each division. Within ISCs, two distinct populations were detected after withdrawal of CD40L. The first had acquired the plasma cell marker CD38 and continued to proliferate despite the absence of CD40L. In contrast, the second population remained CD38(-), ceased dividing, and underwent rapid apoptosis. The former most likely represent the immediate precursors of long-lived plasma cells, which preferentially home to the bone marrow in vivo, whereas the latter contain short-lived ISCs responsible for the initial Ab response to stimulation with Ag and T cell help. Taken together, the results point to a division-based mechanism responsible not only for regulating differentiation of short- and long-lived ISCs from memory B cells, but for preserving the memory B cell pool for reactivation upon subsequent Ag exposure.
Repetitive Sinus-Related Symptoms May Accelerate the Progression of Chronic Maxillary Atelectasis (2017)

Chronic maxillary atelectasis (CMA) is characterized by a progressive decrease in maxillary sinus volume. The factors that promote the stage progression of CMA remain poorly understood. Here, we describe the time course of anatomical changes in a 40-year-old woman with stage II CMA that progressed to stage III disease. She did not show stage progression until she started to develop repetitive sinus-related symptoms. The stage progression was characterized by ocular symptoms. The repetitive inflammatory episodes may have increased the negative pressure in the affected sinus and weakened the bone walls, thereby promoting stage progression. Thus, a history of repetitive sinus-related symptoms may be a risk factor for stage progression in CMA.
A most user-friendly protocol for ring closing metathesis reactions (1999)

Ring closing metathesis reactions (RCM) can be conveniently achieved in a photo-assisted manner simply by heating a solution of the diene substrate, catalytic amounts of commercially available [(p-cymene)RuCl2]2 4 and PCy3 in CH2Cl2 under neon light.
High-temperature gas sensor using perovskite thin films on a suspended microheater (2002)

Suspended microstructures consisting of a thin oxide/nitride diaphragm with embedded polysilicon heaters were designed and fabricated using a standard complementary metal–oxide–semiconductor process and simple postprocessing. Thin films of gas sensitive materials based on the SrFeO2.5+x nonstoichiometric perovskite family were deposited onto the diaphragms by room-temperature pulsed excimer laser deposition. Successful chemical sensor functionality was demonstrated. With applied power up to 30 mW, estimated temperatures of the gas sensor film up to 900 °C were reached. When the device was exposed to volatile organic compounds (VOCs) such as acetone and methanol, a reversible ten to 100-fold increase in sensor film resistance was observed, with response times from less than 1 s to a few minutes. Sensor response sensitivity depended on applied power and on the nature of the VOC analyte. This sensor device has the potential for use in multiarray configurations such as in an electronic nose.
Optimal bandwidth allocation of multiple VBR video sources with priorities (2002)

Transmitting video over ATM networks with a variable-bit-rate coding technique aims to optimize performance and to improve channel efficiency. Particularly the two-layer coding schemes that separate the coded bits into two priority streams are well suited for the ATM standard. This is achieved by giving different access priorities of the shared buffer to the two streams. In the paper, the authors derive a formula to determine the cell loss rates of the two priority streams for multiple VBR video sources under a simple access scheme. They also consider the problem of determining the optimal capacity and buffer allocation to satisfy the QoS requirement of the traffic.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A low-power, small area quadrature LC-VCO using miniature 3D solenoid shaped inductor (2009)

A low-power, small area quadrature 5 GHz LC-VCO includes 20 GHz oscillator and 1/4 divider has been fabricated using a miniature 3D solenoid shaped inductor in 90 nm CMOS. Owing to a small area and a small magnetic energy of the 3D inductor, a chip area of 2597 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> which is 1/10 of the reported smallest LC-VCOs and 2.8 mW power consumption including the divider have been achieved without degrading a figure of merit (FOM). The phase noise was -103 dBc/Hz (@1 MHz offset) and the phase error was <1.3deg. The PLL using this LC-VCO achieved 1.2 ps rms jitter with the chip area as small as that of ring oscillators. This small area LC-VCO is suitable for low-power, low-cost wireless transceivers and high speed communication systems.
The First Decade of the Victorian Court of Appeal (2008)

Before 1995, appeals in the superior courts in Victoria were based on the Full Court model whereby trial judges of the Supreme Court of Victoria were appointed on an ad hoc basis to sit as appeal judges to hear and determine civil and criminal appeals. A similar model was used in most other jurisdictions in Australia. In 1995 a permanent Court of Appeal was created in Victoria. This article discusses the reasons behind the establishment of the Victorian Court of Appeal, and examines the extent to which empirical data can be used to assess the operation of courts of appeal.
Gelation by Acrylamide, a Quasi-Universal Medium for the Synthesis of Fine Oxide Powders for Electroceramic Applications (2000)

The synthesis of fine powders of electroceramic oxides (e.g., superconductors, dielectrics, and materials exhibiting colossal magnetoresistance) is most commonly carried out by solid-state reaction. Wet chemical methods, which overcome some disadvantages of the solid-state route, are often difficult to scale up. The improved acrylamide sol-gel process presented here is shown to be a fast, cheap, reproducible, and easily scaled-up route to fine oxide powders. The synthesis of La2CuNiO6, which cannot be obtained by solid-state reaction at ambient pressure, demonstrates the potential of this method in the search for new materials.
Multi-sensor obstacle tracking for safe human-robot interaction (2022)

For human-robot interaction in industrial applications, monitoring the robot surroundings is essential in order to guarantee the safety of humans sharing the workspace with robots. This contribution presents an approach for obstacle detection and tracking based on the fusion of multiple heterogeneous depth sensors which are mounted on board a mobile manipulator. The proposed methods can track arbitrary obstacles all around the robot. Furthermore, a novel method for extrinsic calibration of the sensors is proposed, using the manipulator as a sensor calibration target. This approach enables a robust and accurate calibration without the need for a dedicated calibration object. Experimental results validate the real-time performance of the proposed obstacle tracking method.
Computer-aided parallelization of continuous media applications (1999)

Parallel servers for I/O and compute intensive continuous media applications are difficult to develop. A server application comprises many threads located in different address spaces as well as files striped over multiple disks located on different computers. The present contribution describes the construction of a continuous media server, the 4D beating heart slice server, based on a computer-aided parallelization tool (CAP) and on a library of parallel file system components enabling the combination of pipelined parallel disk access and processing operations. Thanks to CAP, the presented architecture is concisely described as a set of threads, operations located within the threads and flow of data and parameters (tokens) between operations. Continuous media applications are supported by allowing tokens to be suspended during a period of time specified by a user-defined function. Our target application, the 4D beating heart server supports the extraction of freely oriented slices from a 4D beating heart volume (one 3D volume per time sample). This server application requires both a high I/O throughput for accessing from disks the set of 4D sub-volumes (extents) intersecting the desired slices and a large amount of processing power to extract these slices and to resample them into the display grid. With a server configuration of 3 PCs and 24 disks, up to 7.3 slices can be delivered per second, i.e. 43 MB/s are continuously read from disks and 4.1 MB/s of slice parts are extracted, transfered to the client, merged, buffered and displayed. This performance is close to the maximal performance deliverable by the underlying hardware. The observed single stream server delay jitter varies between 0.6s (52% of maximal display rate) and 1.4s (92% of the maximal display rate). For the same resource utilization, the jitter is proportional to the number of streams that are accessed synchronously.