gebhart/patrepeval huggingface dataset:
Clinical outcomes following real-world computed tomography angiography-derived fractional flow reserve testing in chronic coronary syndrome patients with calcification (2020)

FFRCT shows promise in identifying patients with stenosis and calcification who can be managed without further downstream testing. Moreover, an inverse relationship between CAC levels and FFRCT was demonstrated. Studies are needed to further assess the clinical utility of FFRCT in patients with extensive coronary calcification.
Development of the Flameless Ration Heater for the Meal, Ready-to-Eat (1993)

Abstract : The Flameless Ration Heater (FRH) was developed to provide an alternative method for heating the Meal, Ready-to-Eat (MRE) entree in the field. A survey of flameless heating mechanisms revealed that a water activated electrochemical pad, composed of magnesium-iron alloy dispersed in plastic powders, would most effectively heat an 8 ounce entree. A packaging system was designed to protect the heating device and function as a heater bag for the entree. The resulting system, the FRH, consists of a heater pad enclosed in a paperboard cover and sealed in a high-density, polyethylene bag with preprinted operational instructions. The FRH was tested and evaluated extensively to determine its technical and operational capabilities. The FRH is capable of raising the temperature of an entree from 40 degrees F to 140 degrees F in 12 minutes or less; is operable in ambient temperatures from -25 degrees F to 110 degrees F; may be used by a soldier while on-the-move or in a vehicle or shelter; requires 2 ounces of water to activate; is a lightweight, cost effective and flameless alternative to the fuel bar/canteen cup method of heating; meets military requirements for safety and human factors and is logistically supportable. The Service adopted the FRH for bulk issue in May 1990, and as an MRE component in September 1991.
Novel VEGF Decoy Receptor Fusion Protein Conbercept Targeting Multiple VEGF Isoforms Provide Remarkable Anti-Angiogenesis Effect In Vivo (2013)

VEGF family factors are known to be the principal stimulators of abnormal angiogenesis, which play a fundamental role in tumor and various ocular diseases. Inhibition of VEGF is widely applied in antiangiogenic therapy. Conbercept is a novel decoy receptor protein constructed by fusing VEGF receptor 1 and VEGF receptor 2 extracellular domains with the Fc region of human immunoglobulin. In this study, we systematically evaluated the binding affinity of conbercept with VEGF isoforms and PlGF by using anti-VEGF antibody (Avastin) as reference. BIACORE and ELISA assay results indicated that conbercept could bind different VEGF-A isoforms with higher affinity than reference. Furthermore, conbercept could also bind VEGF-B and PlGF, whereas Avastin showed no binding. Oxygen-induced retinopathy model showed that conbercept could inhibit the formation of neovasularizations. In tumor-bearing nude mice, conbercept could also suppress tumor growth very effectively in vivo. Overall, our study have demonstrated that conbercept could bind with high affinity to multiple VEGF isoforms and consequently provide remarkable anti-angiogenic effect, suggesting the possibility to treat angiogenesis-related diseases such as cancer and wet AMD etc.
Charge Carrier Transport and Photogeneration in P3HT:PCBM Photovoltaic Blends (2015)

This article reviews the charge transport and photogeneration in bulk-heterojunction solar cells made from blend films of regioregular poly(3-hexylthiophene) (RR-P3HT) and methano-fullerene (PCBM). The charge transport, specifically the hole mobility in the RR-P3HT phase of the polymer:fullerene photovoltaic blend, is dramatically affected by thermal annealing. The hole mobility increases more than three orders of magnitude and reaches a value of up to 2 × 10(-4) cm(2) V(-1) s(-1) after the thermal annealing process as a result of an improved semi-crystallinity of the film. This significant increase of the hole mobility balances the electron and hole mobilities in a photovoltaic blend in turn reducing space-charge formation, and this is the most important factor for the strong enhancement of the photovoltaic efficiency compared to an as cast, that is, non-annealed device. In fact, the balanced charge carrier mobility in RR-P3HT:PCBM blends in combination with a field- and temperature-independent charge carrier generation and greatly reduced non-geminate recombination explains the large quantum efficiencies mea-sured in P3HT:PCBM photovoltaic devices.
Design of USB dongle antenna for WLAN applications using theory of characteristic modes (2014)

A compact universal serial bus (USB) antenna design for wireless USB dongle application is presented. The use of the theory of characteristic modes (CMs) to design such an antenna is novel and leads to a systematic antenna design scheme. The physical insight that the CM offers is of great importance for designing such an antenna. The systematic placing of reactive loads on the antenna body plays a key role in matching the antenna at the desired frequency bands. The proposed antenna's overall size is (48 × 10 mm) and it can serve the WLAN IEEE 802.11 a/b/g/n bands (2.4/5.5 GHz). It could also be used for the Bluetooth and LTE applications.
Low Complexity Carrier Frequency Offset Estimation Scheme Based on Zoom-FFT for M-QAM (2019)

We propose a novel low complexity two-stage carrier frequency offset estimation scheme based on Zoom-FFT for M-QAM Numerical simulations and experimental results verify its effectiveness and comparable performance to the single stage FFT and FFT+CZT.
Adult antiretroviral therapy at a glance (2014)

Dealing with the challenges of human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) continues to be a major global and regional health priority. According to estimates by the World Health Organization and the Joint United Nations Programme on HIV/AIDS, 35.3-million people were living with HIV at the end of 2012. That same year, 2.3-million people became newly infected, and 1.6 million died of AIDS-related causes. South Africa has the highest number of people living with HIV and AIDS in the world, with approximately 5.4-million affected individuals. It is important to get tested for HIV regularly, and to recognise the symptoms of HIV as soon as possible since early diagnosis and treatment may help to prevent serious illness. Early treatment also reduces the chances of transmitting the virus to others.
Aprovechamiento del cascote cerámico como material puzolánico (2008)

Las mejoras en los procesos de fabricacion en el sector de la construccion, han minimizado en las industrias el rechazo de materiales considerados no aptos para su comercializacion o materiales de desecho, aunque sigue siendo elevada la cantidad de residuos industriales generados, lo que se traduce en un aumento de la necesidad de vertederos controlados. En un principio, este tipo de materiales puede ser considerado inerte, por tener un poder de contaminacion relativamente bajo. Sin embargo, su impacto visual es elevado, por el gran volumen que ocupan y por el escaso control ambiental ejercido sobre los terrenos que los contienen.

El objetivo de este estudio es mostrar la posibilidad de utilizar materiales de desecho procedentes de arcilla cocida, cascote ceramico, una vez triturados y molidos, como puzolana.
Structural and dielectric properties of Nd3+-doped Ba0.77Ca0.23TiO3 ceramics (2005)

The structural and dielectric properties of both pure and Nd3+-doped Ba0.77Ca0.23TiO3 (BCT23) ceramics obtained from solid-state reaction were investigated. The BCT23 ceramics sintered at 1300 °C for 3 h showed a dense microstructure without the presence of secondary phases. The use of Nd3+ as a dopant affected the microstructure of these ceramics. Samples prepared with Nd3+ exhibit a more homogeneous microstructure without a liquid phase on the grain boundaries. The dielectric constant and Raman scattering measurements indicate that the Curie temperature of the ferroelectric phase transition depends on Nd3+ content. It shifts toward lower temperatures with Nd3+ addition.
EVALUATION OF A FEMORAL STEM WITH REDUCED STIFFNESS (2002)

Contrary to previous studies of other designs with reduced stiffness, the Epoch stem achieved excellent primary fixation. Despite this rigid fixation, the proximal loss of bone-mineral density was less than that associated with the stem with a stiffer design. These results should encourage additional long-term studies with a larger patient population.
Integrating Multiple Data Views for Improved Malware Analysis [Slides] (2013)

Malicious programs continue to be a serious threat within the internet landscape. In 2011, 403 million variants of malware were detected, a 41% increase from 2010. Malware cost consumers $\$$2.3 billion in 2011. Cybercrime cost companies $\$$338 billion in 2011. Given recent trends, and how lucrative the cybercrime industry has become, we can expect malware to be an ongoing threat.
Architecture of a PVR Appliance with 'Long-Tail' Internet-TV Capabilities (2006)

The design and implementation of a networked PVR appliance incorporating support for Internet-TV is described. The appliance incorporates support for the bittorrent protocol and employs user tools for content location, management and scheduling which encourage background downloading of content and it is particularly suited for "long-tail" content distribution applications. The standard bittorrent algorithm has been modified to allow client bandwidth and content storage to be managed from a central content server. With this modified protocol each PVR can function as a combined broadcast and storage node in an Internet-wide distribution system.
Identification of the Major Cysteine Protease of Giardia and Its Role in Encystation (2008)

Giardia lamblia is a protozoan parasite and the earliest branching clade of eukaryota. The Giardia life cycle alternates between an asexually replicating vegetative form and an infectious cyst form. Encystation and excystation are crucial processes for the survival and transmission of Giardia. Cysteine proteases in Giardia have been implicated in proteolytic processing events that enable the continuance of the life cycle throughout encystation and excystation. Using quantitative real-time PCR, the expression of twenty-seven clan CA cysteine protease genes in the Giardia genome was measured during both vegetative growth and encystation. Giardia cysteine protease 2 was the most highly expressed cysteine protease during both life cycle stages measured, with a dramatic expression increase during encystation. The mRNA transcript for Giardia cysteine protease 2 was 7-fold up-regulated during encystation and was greater than 3-fold higher than any other Giardia protease gene product. Recombinant Giardia cysteine protease 2 was expressed, purified, and biochemically characterized. The activity of the recombinant cysteine protease 2 protein was confirmed to be identical to the dominant cysteine protease activity found in G. lamblia lysates. Giardia cysteine protease 2 was co-localized with cyst wall protein in encystation-specific vesicles during encystation and processed cyst wall protein 2 to the size found in Giardia cyst walls. These data suggest that Giardia cysteine protease 2 is not only the major cysteine endoprotease expressed in Giardia, but is also central to the encystation process.
A defective Intramolecular Autoactivation Cascade May Cause the Reduced Kinase Activity of the Skeletal Muscle Insulin Receptor from Patients with Non-insulin-dependent Diabetes Mellitus (1989)

The insulin receptor purified from skeletal muscle of patients with non-insulin-dependent diabetes mellitus (NIDDM) displayed a 25-55% reduction in insulin-stimulated autophosphorylation and tyrosyl-specific phosphotransferase activity relative to controls. This decrease was not explained by alterations of muscle fiber composition, insulin binding affinity or capacity, or the Km values for ATP; the lower kinase activity was entirely attributed to a decrease in the Vmax of the enzyme. Phosphorylation sites in the beta-subunit of the control and diabetic receptor were identified by tryptic digestion and reverse-phase high performance liquid chromatography. Autophosphorylation occurred primarily in two regions of the beta-subunit: the regulatory region containing Tyr-1146, Tyr-1150, and Tyr-1151, and the C terminus containing Tyr-1316 and 1322. Autophosphorylation of the regulatory region at all three tyrosyl residues (tris-phosphorylation) appears to be necessary to activate the receptor kinase (White, M. F., Shoelson, S. E., Stepman, E. W., Keutmann, H. & Kahn, C. R. (1988) J. Biol. Chem. 263, 2969-2980). The receptor from NIDDM patients showed a decreased level of tris-phosphorylation of the regulatory region which was closely associated (r2 = 0.97) with the decreased kinase activity. In contrast, weak associations were found between kinase activity and the bis-phosphorylated forms of the regulatory region (r2 = 0.51) and the C terminus (r2 = 0.35). Therefore, the reduced formation of the tris-phosphorylated regulatory region in the diabetic receptors suggests that a defective autophosphorylation cascade leading to tris-phosphorylation of the regulatory region may cause, in part, the reduced insulin-stimulated kinase activity of the insulin receptor in muscle of NIDDM patients.
Molecular regulation of human interleukin 2 and T-cell function by interleukin 4. (1993)

Distinct functional T-cell subsets, differing in the patterns of lymphokines produced, regulate cell-mediated and humoral immune responses. The two major types and their principal products, interleukin 4 and interferon gamma (IL-4 and IFN-gamma), are reciprocally negatively interactive. To analyze the molecular mechanism of IL-4-mediated suppression of cell-mediated immunity we studied its effects on expression of interleukin 2 (IL-2) and IFN-gamma. IL-4 pretreatment of Jurkat cells prior to stimulation resulted in a decrease in transcription of the IL2 gene. IL-4 suppressed IL-2 and IFN-gamma mRNA levels in primary human T cells, and addition of anti-CD28 antibodies relieved this suppression. Using enhancer-reporter constructs, IL-4 specifically down-regulated the NFIL-2B element. Electrophoretic mobility shift assays using a DNA oligomer containing the NFIL-2B binding site indicated that IL-4 inhibited the NFIL-2B complex and that the NFIL-2B DNA binding factor is distinct from AP-1. These results suggest that IL-4 may regulate development and function of T-cell subsets involved in cell-mediated immunity in part by inhibiting factors required for transcription of the IL2 gene.
A low-noise transimpedance amplifier for the detection of “Violin-Mode” resonances in advanced Laser Interferometer Gravitational wave Observatory suspensions (2014)

This paper describes the design and performance of an extremely low-noise differential transimpedance amplifier, which takes its two inputs from separate photodiodes. The amplifier was planned to serve as the front-end electronics for a highly sensitive shadow-displacement sensing system, aimed at detecting very low-level "Violin-Mode" (VM) oscillations in 0.4 mm diameter by 600 mm long fused-silica suspension fibres. Four such highly tensioned fibres support the 40 kg test-masses/mirrors of the Advanced Laser Interferometer Gravitational wave Observatory interferometers. This novel design of amplifier incorporates features which prevent "noise-gain peaking" arising from large area photodiode (and cable) capacitances, and which also usefully separate the DC and AC photocurrents coming from the photodiodes. In consequence, the differential amplifier was able to generate straightforwardly two DC outputs, one per photodiode, as well as a single high-gain output for monitoring the VM oscillations-this output being derived from the difference of the photodiodes' two, naturally anti-phase, AC photocurrents. Following a displacement calibration, the amplifier's final VM signal output was found to have an AC displacement responsivity at 500 Hz of (9.43 ± 1.20) MV(rms) m(-1)(rms), and, therefore, a shot-noise limited sensitivity to such AC shadow- (i.e., fibre-) displacements of (69 ± 13) picometres/√Hz at this frequency, over a measuring span of ±0.1 mm.
Direct Synthesis of Perylene‐Fused Cyclic Ketones from Perylene and 2‐Alkenoic Acids (2016)

An efficient, one‐pot methodology of direct synthesis of perylene‐fused cyclic ketones from perylene and 2‐alkenoic acids under acidic catalytic conditions has been developed. The reaction of perylene with 2,3‐disubstituted 2‐alkenoic acid leads, via Friedel–Crafts acylation followed by Nazarov cyclization, to the formation of disubstituted 5,6‐dihydro‐4 H ‐cyclopenta[ b ]perylen‐4‐ones in high yield (up to 97 %) and high diastereoselectivity, whereas the reaction with acrylic acid leads, via alkylation followed by intramolecular Friedel–Crafts acylation, to 2,3‐dihydro‐1 H ‐benzo[ cd ]perylen‐1‐one.
Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system (2004)

We describe a murine model of early pregnancy failure induced by systemic activation of the CD40 immune costimulatory pathway. Although fetal loss involved an NK cell intermediate, it was not due to lymphocyte-mediated destruction of the fetus and placenta. Rather, pregnancy failure resulted from impaired progesterone synthesis by the corpus luteum of the ovary, an endocrine defect in turn associated with ovarian resistance to the gonadotropic effects of prolactin. Pregnancy failure also required the proinflammatory cytokine TNF-alpha and correlated with the luteal induction of the prolactin receptor signaling inhibitors suppressor of cytokine signaling 1 (Socs1) and Socs3. Such links between immune activation and reproductive endocrine dysfunction may be relevant to pregnancy loss and other clinical disorders of reproduction.
On the teaching reform and countermeasures in the local college (2015)

This paper mainly interprets the exploration and practice of teaching reform for English majors in Handan College from English talents’ goals and model of cultivation, teachers construction, teaching materials construction, curriculum design and construction, teaching methods and means, practice teaching and evaluation system. At the end of the paper, some problems in the current teaching reform and countermeasures are put forward
Extension of a transformation system for maintenance: dealing with data-intensive programs (1994)

The paper, following the theme set out in a previous paper by K.H. Bennett et al. (see ibid., 1992) provides more results of the research programme on reverse engineering. It concentrates on dealing with data-intensive programs such as those written in COBOL. The problems with data-intensive programs are addressed, our solutions to these problems are discussed, a prototype built on our approach is described and the results of the experiments are presented. It is concluded that formal transformations provide a way of combining design decisions which have become instantiated in both the code and the data structures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
<i>At</i>RabF2b (Ara7) acts on the vacuolar trafficking pathway in tobacco leaf epidermal cells (2004)

Rab GTPases are universal key regulators of intracellular secretory trafficking events. In particular, Rab 5 homologues have been implicated in endocytic events and in the vacuolar pathway. In this study, we investigate the location and function of a member of this family, AtRabF2b (Ara7) in tobacco (Nicotiana tabacum) leaf epidermal cells using a live cell imaging approach. Fluorescent-tagged AtRabF2b[wt] localized to the prevacuolar compartment and Golgi apparatus, as determined by coexpression studies with fluorescent markers for these compartments. Mutations that impair AtRabF2b function also alter the subcellular location of the GTPase. In addition, coexpression studies of the protein with the vacuole-targeted aleurain-green fluorescent protein (GFP) and rescue experiments with wild-type AtRabF2b indicate that the dominant-negative mutant of AtRabF2b causes the vacuolar marker to be secreted to the apoplast. Our results indicate a clear role of AtRabF2b in the vacuolar trafficking pathway.
<title>Flat-panel autostereoscopic display</title> (2001)

In the design of an autostereoscopic display system we usually deal with trade-offs among resolution, number of viewing- zones, and brightness. A viewer-tracking-based autostereoscopic display, with a micro-retardation array for image splitting, can achieve reasonable balance among these properties simultaneously. However, the bulkiness due to the hard-to-decrease f-number of the field lens used to direct light to the viewer presents a problem. In this paper, we introduce a newly-developed flat-panel autostereoscopic display system. Instead of using a large format field lens, a precise lenticular plate, with an LCD tracking panel on its back focal plane, is attached to the LCD image panel and acts as both the backlight and the tracking device. The total depth of the system is condensed to the order of several centimeters under such a configuration. Both micro-retardation array and micro-prism can be used as the images splitter of such a system. In order to avoid the crosstalk caused by the optical leakage between adjacent columns, a vertically interlaced blazed grating should be used in place of the striped-wise micro-prism fabricated by mechanical machining. A display with 6' screen in diagonal is constructed for feasibility study, in which a micro-retardation array is used as the image splitter and combination of micro-retardation array and a polarizer is used to stimulate the tracking LCD. Detailed performance evaluation of the system is addressed.
Streamflow—Water year 2020 (2021)

First posted September 7, 2021 For additional information, contact: U.S. Geological Survey 415 National Center Reston, Virginia 20192Contact Pubs Warehouse The maps and graphs in this summary describe national streamflow conditions for water year 2020 (October 1, 2019, to September 30, 2020) in the context of streamflow ranks relative to the 91-year period of water years 1930–2020. Annual runoff in the Nation’s rivers and streams during water year 2020 (11.10 inches) was higher than the long-term (1930–2020) mean annual runoff of 9.40 inches for the contiguous United States. Nationwide, the 2020 streamflow ranked the 10th highest out of the 91 years.
Muscular strength at 5 years of children with a birthweight under 1500g (1988)

The hand-grip strength was measured as part of the 5-year neurodevelopmental assessment of 24 very low birthweight (VLBW) and 18 normal birthweight (NBW) children. Hand-grip strength was significantly lower in the VLBW children for left and right hands tested individually and for both hands used concurrently. Increasing hand-grip strength was significantly related to 5-year weight percentiles and to being in the NBW group. More of the VLBW children weighed less than the 10th percentile. After adjusting for the 5-year weight percentile, the hand-grip strength of VLBW children was still significantly lower than that for NBW children. This is another aspect of development in which VLBW children are disadvantaged.