gebhart/patrepeval huggingface dataset:
Synchronously Deployable Truss Structures (1986)

Structure lightweight, readily deployed, and has reliable joints. New truss concept, designated as pac truss, developed. Features easy deployment without need for complex mechanisms. Structures of this type deployed in free flight by controlled release of stored energy in torsional springs at selected hinges located throughout structure. Double-folding technique used in beam model applicable to flat planar trusses, allowing structures of large expanse to fold into compact packages and be deployed for space-platform applications.
Knowledge Graph-Based Query Rewriting in a Relational Data Harmonization Framework (2016)

There are diverse data providers, storage formats and data schemas in many modern application domains from sales and marketing to health care. This leads to a high demand for a harmonized data management platform that hides the heterogeneity of the system from the end user. Using an abstraction layer that provides a single logical view of all data located in disparate data sources, makes the implementation of a harmonized data management platform effortless. This abstraction layer is called Data Virtualization and it can query the data sources via a single query which is usually in the common SQL format. However, the user needs to know where the desired data is located before submitting the SQL query to the virtualization middleware. In this paper, we present how to capture inter-database associations of relational data stores as a Resource Description Framework (RDF) graph for the purpose of automation in Data Virtualization. Furthermore, we propose an approach to enrich a naïve input SPARQL which can query the RDF graph and translate it to a SQL query that will be fed into the virtualization layer. Combining these two approaches results in the transparency of the data harmonization framework.
Demonstrating The Incremental Interaction Manager In An End-To-End "Lets Go!" Dialogue System (2012)

The Incremental Interaction Manager supports the use of incremental speech recognition with conventional turn-based dialogue managers. We demonstrate its use in a complete statistical dialogue system in the “Lets Go” bus information domain. Our demonstration is two-fold. First, the user is able to call the system and have a complete dialogue. They are then able to inspect their own call using a visualizer or load logs of previous calls for a fuller picture of the system’s capabilities.
Fiber‐optic Raman spectroscopy probes gastric carcinogenesis <i>in vivo</i> at endoscopy (2012)

Intestinal-type gastric carcinogenesis is a complex multi-step disease, and early precursors (e.g. intestinal metaplasia (IM), dysplasia) can be very challenging to identify using conventional white-light endoscopic imaging. This study aims to assess the capability of Raman spectroscopy for multi-class elucidation of intestinal-type gastric carcinogenesis sequence in vivo for improving precancer detection at endoscopy. We employ a novel image-guided Raman endoscopy technique developed for in vivo gastric tissue Raman measurement within 0.5 s during clinical endoscopic examination. We have acquired a total of 1277 in vivo Raman spectra from 83 gastric patients associated with intestinal-type carcinogenesis. In vivo Raman spectroscopy integrated with semi-quantitative spectral modelling (e.g. DNA, lipids, glycoprotein, proteins and blood) reveals the progressive changes of biochemical constituents in gastric tissue associated with preneoplastic and neoplastic transformation (i.e., IM, dysplasia and adenocarcinoma). Multi-class probabilistic partial least squares-discriminant analysis (PLS-DA) diagnostic algorithms based on in vivo Raman spectra are able to identify normal mucosa with sensitivity of 75.88% and specificity of 87.21%; IM with sensitivity of 46.67% and specificity of 87.55%; dysplasia with sensitivity of 83.33%; specificity of 95.80%, and adenocarcinoma with sensitivity of 84.91% and specificity 95.57%, respectively. This work demonstrates that Raman spectroscopy is a sensitive biomolecular probe for monitoring intestinal-type gastric carcinogenesis to realize early diagnosis and detection of precancer and early gastric cancer in vivo during clinical endoscopic examination.
Anti-Interference Deep Visual Identification Method for Fault Localization of Transformer Using a Winding Model (2019)

The idea of Ubiquitous Power Internet of Things (UPIoTs) accelerates the development of intelligent monitoring and diagnostic technologies. In this paper, a diagnostic method suitable for power equipment in an interference environment was proposed based on the deep Convolutional Neural Network (CNN): MobileNet-V2 and Digital Image Processing (DIP) methods to conduct fault identification process: including fault type classification and fault localization. A data visualization theory was put forward in this paper, which was applied in frequency response (FR) curves of transformer to obtain dataset. After the image augmentation process, the dataset was input into the deep CNN: MobileNet-V2 for training procedures. Then a spatial-probabilistic mapping relationship was established based on traditional Frequency Response Analysis (FRA) fault diagnostic method. Each image in the dataset was compared with the fingerprint values to get traditional diagnosing results. Next, the anti-interference abilities of the proposed CNN-DIP method were compared with that of the traditional one while the magnitude of the interference gradually increased. Finally, the fault tolerance of the proposed method was verified by further analyzing the deviations between the wrong diagnosing results with the corresponding actual labels. Experimental results showed that the proposed deep visual identification (CNN-DIP) method has a higher diagnosing accuracy, a stronger anti-interference ability and a better fault tolerance.
Specific Immune Adherence Assay for Human Hepatitis A Antibody. Application to Diagnostic and Epidemiologic Investigations (1975)

A specific immune adherence (IA) test for hepatitis A antibody in human serum was described employing liver extract of marmosets infected with CR326 strain human hepatitis A virus. Persons with hepatitis A, but not hepatitis B, developed hepatitis A IA antibody soon after onset of the acute illness and this persisted thereafter. There was very close agreement in the tests for human hepatitis A immune adherence, complement fixing (CF) and neutralizing antibodies. IA antibodies appeared to develop somewhat later than CF or neutralizing antibody. A limited epidemiologic study of a family outbreak of hepatitis A and B in Costa Rica showed simultaneous occurrence of the two diseases and was supportive of the concept that susceptible persons in a country with high hepatitis A prevalence generally acquire their infections at an early age and are immune thereafter. Most persons of high socioeconomic level in an area of low hepatitis A incidence may proceed to adulthood without experience with hepatitis A. Person of low socioeconomic level, however, such as commercial blood bank donors and prisoners, show high incidence of hepatitis A antibody. Hepatitis IA and CF antibodies persisted in human subjects for at least 7 hr after hepatitis A virus infection. Captive chimpanzees and grivet and rhesus monkeys, not given hepatitis A virus, showed evidence of previous experience with human hepatitis A or an antigenically related virus based on tests for hepatitis A antibody. Other subhuman primates, rodents, and swine, not given hepatitis A virus, were without hepatitis A antibody. The IA test provides an excellent tool for diagnostic and epidemiologic investigations of hepatitis A and should be of considerable value to detect hepatitis A virus in attempts to propagate the virus in cell culture. There was considerable difference in hepatitis A IA antibody content of different lots of commercial human immune globulin, though the majority titered 1:4000 or 1:8000.
Enzymatically Active ADAMTS13 Variants Are Not Inhibited by Anti-ADAMTS13 Autoantibodies (2005)

ADAMTS13 (a disintegrin and metalloprotease with thrombospondin motifs), a circulating multidomain zinc metalloprotease of the reprolysin subfamily, is critical for preventing von Willebrand factor-platelet interaction under high shear stress conditions. A deficiency of the protease, due to mutations in the ADAMTS13 gene or the presence of antibodies that inhibit the activity of the protease, causes thrombotic thrombocytopenic purpura (TTP). Plasma therapy, the conventional therapy for TTP, may cause serious adverse reactions and is ineffective in some patients. In order to develop new strategies for improving the diagnosis and treatment of TTP, we produced a series of truncated ADAMTS13 proteins in mammalian cells and analyzed their binding with and suppression by the IgG derived from the TTP patients. The results revealed that truncation of the ADAMTS13 protein at its cysteine-rich region eliminated its recognition by the antibodies without abolishing its von Willebrand factor-cleaving activity. This raises the possibility that resistant ADAMTS13 variants may be exploited to circumvent inhibitory antibodies that cause TTP.
A folding variant of α‐lactalbumin with bactericidal activity against <i>Streptococcus pneumoniae</i> (2000)

This study describes an alpha-lactalbumin folding variant from human milk with bactericidal activity against antibiotic-resistant and -susceptible strains of Streptococcus pneumoniae. The active complex precipitated with the casein fraction at pH 4.6 and was purified from casein by a combination of anion exchange and gel chromatography. Unlike other casein components, the active complex was retained on the ion-exchange matrix and eluted only with high salt. The eluted fraction showed N-terminal and mass spectrometric identity with human milk alpha-lactalbumin, but native alpha-lactalbumin had no bactericidal effect. Spectroscopic analysis demonstrated that the active form of the molecule was in a different folding state, with secondary structure identical to alpha-lactalbumin from human milk whey, but fluctuating tertiary structure. Native alpha-lactalbumin could be converted to the active bactericidal form by ion-exchange chromatography in the presence of a cofactor from human milk casein, characterized as a C18:1 fatty acid. Analysis of the antibacterial spectrum showed selectivity for streptococci; Gram-negative and other Gram-positive bacteria were resistant. The folding variant of alpha-lactalbumin is a new example of naturally occurring molecules with antimicrobial activity.
To mine capture intention of camcorder users (2005)

In this paper, we present a learning-based approach to mining the capture intention of camcorder users, aiming at providing a novel viewpoint in terms of home video content analysis. In contrast to existing approaches to video analysis designed from the viewers' standpoint, this approach models the capture intention from a camcorder user's point of view, by investigating a set of effective intention oriented features. With this approach, not only the capture intention is effectively mined, but also a set of intention probability curves are produced for efficient browsing of home video content. The experimental evaluations indicate that the intention based approach is an effective complement to existing home video content analysis schemes.
Purified beta-chain of MHC class II binds to CD4 molecules on transfected HeLa cells (1993)

The initial event triggering the activation of Th cells occurs when the TCR interacts with antigenic peptide in the context of the MHC II on APC. Various T cell accessory molecules including CD4, CD28, and LFA-1 participate and facilitate the activation event. Although some evidence for the interaction of MHC II and CD4 is available, the site of MHC class II (alpha-chain, beta-chain, or both chains) for CD4 interaction has not yet been clearly defined. Results from different laboratories had indicated the involvement of alpha 1, beta 1, and beta 2 domains of MHC class II molecules in CD4 interaction. Recently, a conserved site of DR beta 2 domain has been identified that involves CD4 interaction that is analogous to MHC class I binding site for CD8 molecule. In this report, direct binding of affinity-purified HLA-DR2 dimer and its isolated alpha- and beta-chains to CD4 was studied using a CD4-transfected HeLa cell line. Preferential binding of the beta-chain and intact MHC II dimer to the CD4-transfected cells was observed and found to be specifically inhibited by anti-CD4 mAb. In contrast, the isolated alpha-chain of HLA DR2 did not show significant binding to CD4-transfected cells. Complexes of radiolabeled DR2 dimer or beta-chain alone with an immunodominant epitope from myelin basic protein (83-102) did not show any further increase in binding of these molecules. Binding of the beta-chain to CD4+ cells was markedly inhibited by a DR beta 1 peptide (35-46) and was partially inhibited by a DR beta 2 peptide (134-148) of MHC class II molecule. These results suggest the involvement of at least two conserved regions of the beta polypeptide chain of MHC class II in CD4 interaction. Because in our experiments transfected cells lack TCR molecules and the binding of DR2 to the CD4-transfected cells was unaffected by added antigenic peptide, it is possible that the interaction of MHC class II to CD4 is independent of TCR occupancy.
Selection Strategy for Site-Directed Mutagenesis Based on Altered β-Lactamase Specificity (1998)

Conventional approaches to oligonucleotide-directed mutagenesis rely upon the application of a selection strategy to maximize mutagenesis efficiencies. We have developed a mutagenesis procedure that incorporates a novel antibiotic resistance for selection. The selection involves altering the substrate specificity of TEM-1 beta-lactamase, the enzyme responsible for bacterial resistance to beta-lactam antibiotics such as ampicillin. The gene encoding beta-lactamase is commonly found on cloning and shuttle vectors used in molecular biology. Amino acid substitutions in several active site residues of beta-lactamase result in increased hydrolytic activity against extended-spectrum penicillins and cephalosporins. This increased activity confers a novel resistance specific to the mutant and thus provides the basis of the selection strategy. We describe a simple and efficient mutagenesis procedure and its application to creating a range of oligonucleotide-directed mutants.
Discrete Fourier Transform Radar in the Terahertz-Wave Range Based on a Resonant-Tunneling-Diode Oscillator (2021)

We used a resonant-tunneling-diode (RTD) oscillator as the source of a terahertz-wave radar based on the principle of the swept-source optical coherence tomography (SS-OCT). Unlike similar reports in the terahertz range, we apply the stepwise frequency modulation to a subcarrier obtained by amplitude modulation instead of tuning the terahertz carrier frequency. Additionally, we replace the usual optical interference with electrical mixing and, by using a quadrature mixer, we can discriminate between negative and positive optical path differences, which doubles the measurement range without increasing the measurement time. To measure the distance to multiple targets simultaneously, the terahertz wave is modulated in amplitude at a series of frequencies; the signal returning from the target is detected and homodyne mixed with the original modulation signal. A series of voltages is obtained; by Fourier transformation the distance to each target is retrieved. Experimental results on one and two targets are shown.
OPTICAL ACTIVITIES IN INDUSTRY Miniature aspheric lenses with spherical index gradients (1994)

Miniature aspheric and anamorphic plastic lenses are built from liquid droplets suspended on circular or elliptical-shaped pedestals. Refractive-index gradients are formed by the flow of premixed monomer volumes through a central conduit by the use of computer-controlled syringe pumps.
Status of the Development of Superconducting Undulators at the Advanced Photon Source (2018)

Superconducting undulators (SCUs) are electromagnetic undulators that employ superconducting coils for generating magnetic field. Magnetic simulations suggest that superconducting undulator technol...
Online Grid-Based Dynamic Arrival Time Prediction Using GPS Locations (2013)

Transportation modes are aplenty in today's urban environment.Commuters use public transport such as buses, trains, taxis, personal motor vehicles, walking, bicycles, etc. to travel between places.One of the major concerns for the people who rely on public transportation is the unavailability or inaccuracy of systems that predict the estimated arrival time or the schedule based on the current location of vehicles and the traffic situation.With the advent of technology, a large set of urban transportation operators have begun to use location reporting systems such as GPS devices on-board their fleet, with the primary purpose of monitoring and managing their fleet.This paper describes methods for predicting the arrival time taking advantage of the location reports from such devices.The system pipeline developed is based on a complex event processing engine within which an algorithm is implemented to continuously predict in real-time the estimated arrival time in an online fashion.The developed system in first phase is evaluated using a vehicle simulator that generates vehicle trajectories along real public transportation routes.
Fertility of range beef bulls grouped according to presence or absence of heparin-binding proteins in sperm membranes and seminal fluid2 (1994)

Trials were performed to determine the relationship of heparin-binding proteins (HBP) to fertility of bulls. Red Angus (142), Santa Gertrudis (59), Gelbvieh (59), and Santa Gertrudis x Gelbvieh (40) bulls were identified according to the presence or absence of the greatest affinity HBP (HBP-B5) on sperm membranes and in seminal fluid. Nine to 20 bulls with the same HBP-B5 profiles were assigned to pastures with Santa Gertrudis cows at a ratio of 1 bull:25 cows. Fertility for Group 1 (80 bulls with HBP-B5 in sperm membranes but undetectable HBP-B5 in seminal fluid, in six pastures) was 82% pregnant of 1,692 cows. Group 2 bulls (48 bulls with HBP-B5 detectable in seminal fluid and in sperm membranes, in four pastures) impregnated 67% of 919 cows. Fertility for Group 3 (37 bulls with HBP-B5 in seminal fluid but undetectable HBP-B5 in the sperm membranes, in three pastures) and Group 4 (56 bulls with undetectable HBP-B5 in seminal fluid and sperm, in four pastures) was 63% pregnant of 747 and 1,208 cows, respectively. Group 1 had an average of 17% greater fertility compared with Groups 2, 3, and 4 (P < .05). In conclusion, groups with the greatest affinity HBP-B5 in sperm membranes but not in seminal fluid had greater fertility than did groups with other HBP-B5 profiles.
In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B2 receptor antagonist in clinical development (2022)

PHA-022121 is a novel small molecule bradykinin B<sub>2</sub> receptor antagonist, in clinical development for the treatment and prevention of hereditary angioedema attacks. The present study describes the in vitro pharmacological characteristics of PHA-022121 and its active metabolite, PHA-022484 (M2-D). In mammalian cell lines, PHA-022121 and PHA-022484 show high affinity for the recombinant human bradykinin B<sub>2</sub> receptor with K<sub>i</sub> values of 0.47 and 0.70 nM, respectively, and potent antagonism of the human bradykinin B<sub>2</sub> receptor with K<sub>b</sub> values of 0.15 and 0.26 nM, respectively (calcium mobilization assay). Antagonist potency at the recombinant cynomolgus monkey bradykinin B<sub>2</sub> receptor is similarly high (K<sub>b</sub> values of 1.42 and 1.12 nM for PHA-022121 and PHA-022484, respectively), however, potency at rat, mouse, rabbit and dog bradykinin B<sub>2</sub> receptors is at least 100-fold lower than the potency at the human receptor for both compounds. In the human umbilical vein contractility assay, both PHA-022121 and PHA-022484 show a potent, surmountable and reversible B<sub>2</sub> antagonist activity with pA<sub>2</sub> values of 0.35 and 0.47 nM, respectively. The in vitro off-target profile of PHA-022121 and PHA-022484 demonstrates a high degree of selectivity over a wide range of molecular targets, including the bradykinin B<sub>1</sub> receptor. It is concluded that PHA-022121 is a novel, low-molecular weight, competitive antagonist of the human bradykinin B<sub>2</sub> receptor with high affinity, high antagonist potency, and high selectivity. It is about 20-fold more potent than icatibant at the human bradykinin B<sub>2</sub> receptor as assessed using recombinant or endogenously expressed receptors.
Unsupervised Document Embedding With CNNs (2017)

We propose a new model for unsupervised document embedding. Leading existing approaches either require complex inference or use recurrent neural networks (RNN) that are difficult to parallelize. We take a different route and develop a convolutional neural network (CNN) embedding model. Our CNN architecture is fully parallelizable resulting in over 10x speedup in inference time over RNN models. Parallelizable architecture enables to train deeper models where each successive layer has increasingly larger receptive field and models longer range semantic structure within the document. We additionally propose a fully unsupervised learning algorithm to train this model based on stochastic forward prediction. Empirical results on two public benchmarks show that our approach produces comparable to state-of-the-art accuracy at a fraction of computational cost.
1-[4-[(Trimethylsilyl)ethynyl]phenyl]-2,6,7-trioxabicyclo[2.2.2]octanes: a novel type of selective proinsecticide (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-[4-[(Trimethylsilyl)ethynyl]phenyl]-2,6,7-trioxabicyclo[2.2.2]octanes: a novel type of selective proinsecticideChristopher J. Palmer, Ian H. Smith, Matthew D. V. Moss, and John E. CasidaCite this: J. Agric. Food Chem. 1990, 38, 4, 1091–1093Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://doi.org/10.1021/jf00094a040RIGHTS & PERMISSIONSArticle Views55Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (384 KB) Get e-Alerts Get e-Alerts