gebhart/patrepeval huggingface dataset:
Centimeter‐Scale High‐Resolution Metrology of Entire CVD‐Grown Graphene Sheets (2011)

A high-throughput metrology method for measuring the thickness and uniformity of entire large-area chemical vapor deposition-grown graphene sheets on arbitrary substrates is demonstrated. This method utilizes the quenching of fluorescence by graphene via resonant energy transfer to increase the visibility of graphene on a glass substrate. Fluorescence quenching is visualized by spin-coating a solution of polymer mixed with fluorescent dye onto the graphene then viewing the sample under a fluorescence microscope. A large-area fluorescence montage image of the dyed graphene sample is collected and processed to identify the graphene and indicate the graphene layer thickness throughout the entire graphene sample. Using this metrology method, the effect of different transfer techniques on the quality of the graphene sheet is studied. It is shown that small-area characterization is insufficient to truly evaluate the effect of the transfer technique on the graphene sample. The results indicate that introducing a drop of acetone or liquid poly(methyl methacrylate) (PMMA) on top of the transfer PMMA layer before soaking the graphene sample in acetone improves the quality of the graphene dramatically over immediately soaking the graphene in acetone. This work introduces a new method for graphene quantification that can quickly and easily identify graphene layers in a large area on arbitrary substrates. This metrology technique is well suited for many industrial applications due to its repeatability and flexibility.
High-level expression of the human-.ALPHA.-interferon gene through the use of an improved baculovirus vector in the silkworm, Bombyx mori. (1987)

During research on the production of human α-interferon (α-IFN) in silkworms using a baculovirus, Bombyx mori nuclear polyhedrosis virus (BmNPV), as a vector, the expression of approximately 5.0×107 U/ml of α-IFN in the haemolymph was attained. In order to obtain a much higher level of expression, we paid special attention to the role of the sequence between the promoter and the translation start site of the polyhedrin gene, and found that deletion of the sequence led to depression of the expression. We therefore tried to improve the cloning vector. By means of the in vitro mutagenesis technique, a cloning vector retaining this sequence and having various restriction enzyme sites between the promoter and the terminator of the polyhedrin gene was constructed. Using this vector, a transfer vector was constructed in which the polyhedrin structural gene was replaced by human α-IFN, and recombinant viruses were prepared. When silkworms were infected with the recombinant viruses, about 1.9×108 U/ml of IFN was produced in the haemolymph of fifth instar larvae. The improvement of the vector raised the productivity of IFN approximately four-fold.
Black silicon photovoltaics (2014)

An overview and comparison of different fabrication methods of black silicon is presented. Guidelines to optimize relevant parameters such as spatial frequencies and surface defect densities for optoelectronic applications such as photovoltaics will be given.
Imaging properties of pixellated scintillators with deep pixels (2014)

We have investigated the light-transport properties of scintillator arrays with long, thin pixels (deep pixels) for use in high-energy gamma-ray imaging. We compared 10×10 pixel arrays of YSO:Ce, LYSO:Ce and BGO (1mm × 1mm × 20 mm pixels) made by Proteus, Inc. with similar 10×10 arrays of LSO:Ce and BGO (1mm × 1mm × 15mm pixels) loaned to us by Saint-Gobain. The imaging and spectroscopic behaviors of these scintillator arrays are strongly affected by the choice of a reflector used as an inter-pixel spacer (3M ESR in the case of the Proteus arrays and white, diffuse-reflector for the Saint-Gobain arrays). We have constructed a 3700-pixel LYSO:Ce Prototype NIF Gamma-Ray Imager for use in diagnosing target compression in inertial confinement fusion. This system was tested at the OMEGA Laser and exhibited significant optical, inter-pixel cross-talk that was traced to the use of a single-layer of ESR film as an inter-pixel spacer. We show how the optical cross-talk can be mapped, and discuss correction procedures. We demonstrate a 10×10 YSO:Ce array as part of an iQID (formerly BazookaSPECT) imager and discuss issues related to the internal activity of <sup>176</sup>Lu in LSO:Ce and LYSO:Ce detectors.
Iron-core superconducting magnet design and test results for Maglev application (1995)

Design and test results are presented for a superconducting electromagnet for levitating and propelling Maglev vehicles at high velocities. A U-shaped iron core carries a superconducting magnet around its back leg and a normal control coil around each leg of the U-core. The open side of the U-core is bridged by an iron rail through a large airgap between the poles of the U-core and the iron rail. The superconducting magnet is nominally designed to operate in a steady-state DC mode with current variations limited to rates less than 1 Hz. Faster flux variations due to gap changes are accommodated by current changes in the normal control coils. A feedback controller using the airgap and acceleration inputs controls current variations in the superconducting coil. Grumman has designed, fabricated and tested such an electromagnet. This test magnet is 2/3 of the full-size magnet that Grumman specified in their 1992 Concept Definition Study for the National Maglev Initiative. The purpose of these tests is to demonstrate the feasibility of operating and controlling a superconducting electromagnet in the specified environment. This paper discusses static magnet levitation characteristics as functions of airgap length and superconducting magnet excitation. Good correlation is observed between the calculated and measured performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Segmented-plasma-excitation recombination lasers (1981)

A high-voltage, high current pulse is applied to a series of two or more conducting strips (101-110) installed in series in a laser cavity (150-151) containing either a buffer gas or a vacuum. The strips are separated by small gaps. When the high-voltage, high-current pulse is applied to the strips, plasmas (141-149) are formed in the gap regions. The plasmas are comprised of ions from the strip material. Once formed, these plasmas expand hemispherically, cool and recombine to provide laser action. The composition of the plasmas depends on the strip material, the electric field in the gaps, the gap size and the background gas type and pressure.
Measuring sickle cell morphology during blood flow (2017)

During a sickle cell crisis in sickle cell anemia patients, deoxygenated red blood cells may change their mechanical properties and block small blood vessels, causing pain, local tissue damage, and possibly organ failure. Measuring the structural and morphological changes in sickle cells is important for understanding the factors contributing to vessel blockage and for developing an effective treatment. In this work, we image blood cells from sickle cell anemia patients using spectrally encoded flow cytometry, and analyze the interference patterns between reflections from the cell membranes. Using a numerical simulation for calculating the interference pattern obtained from a model of a red blood cell, we propose an analytical expression for the three-dimensional shape of characteristic sickle cells and compare our results to a previously suggested model. Our imaging approach offers new means for analyzing the morphology of sickle cells, and could be useful for studying their unique physiological and biomechanical properties.
Imaging heart motion using harmonic phase MRI (2000)

This paper describes a new image processing technique for rapid analysis and visualization of tagged cardiac magnetic resonance (MR) images. The method is based on the use of isolated spectral peaks in spatial modulation of magnetization (SPAMM)-tagged magnetic resonance images. We call the calculated angle of the complex image corresponding to one of these peaks a harmonic phase (HARP) image and show that HARP images can be used to synthesize conventional tag lines, reconstruct displacement fields for small motions, and calculate two-dimensional (2-D) strain. The performance of this new approach is demonstrated using both real and simulated tagged MR images. Potential for use of HARP images in fast imaging techniques and three-dimensional (3-D) analyses are discussed.
All-digital low-power CMOS pulse generator for UWB system (2004)

An all-digital CMOS ultra-wideband (UWB) pulse generator which complies with FCC regulations is presented. The proposed pulse generator generates a single UWB pulse satisfying FCC regulations without any filtering. The average power consumption of the whole circuit is 15.4 mW and 675 µW at the pulse repetition frequency of 500 and 1 MHz, respectively.
Water Extract of <i>Dolichos lablab</i> Attenuates Hepatic Lipid Accumulation in a Cellular Nonalcoholic Fatty Liver Disease Model (2016)

Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is rising in prevalence worldwide. Therapeutic strategies for patients with NAFLD are limited by a lack of effective drugs. In this report, we show that Dolichos lablab water extract (DLL-Ex) protects against free fatty acid (FFA)-induced lipid accumulation and attenuates expression of genes involved in lipid droplet accumulation in cellular NAFLD models. The hepatoprotective effects and underlying mechanism of DLL-Ex were assessed using an in vitro cellular model in which NAFLD was simulated by inducing excessive FFA influx into hepatocytes. HepG2 cells were treated with DLL-Ex and FFAs for 24 h, after which intracellular lipid content was observed by using Nile Red and Oil Red O staining. Quantitative real-time polymerase chain reaction was used to measure expression levels of genes related to FFA-mediated cellular energy depletion. Western blotting was used to measure protein levels of phosphorylated c-Jun N-terminal kinase, AMP-activated protein kinase alpha (AMPKα), and peroxisome proliferator-activated receptor γ coactivator 1 alpha. In HepG2 cells, DLL-Ex inhibited expression of CD36, which regulates fatty acid uptake, as well as BODIPY-labeled fatty acid uptake. Additionally, DLL-Ex significantly attenuated FFA-mediated cellular energy depletion and mitochondrial membrane depolarization. Furthermore, DLL-Ex enhanced phosphorylation of AMPK, indicating that AMPK is a critical regulator of DLL-Ex-mediated inhibition of hepatic lipid accumulation, possibly through its antioxidative effect. These results demonstrate that DLL-Ex exerts potent anti-NAFLD activity, suggesting that it could be a potential adjuvant treatment for patients with NAFLD.
A short-wave infrared otoscope for middle ear disease diagnostics (Conference Presentation) (2016)

Otitis media, a range of inflammatory conditions of the middle ear, is the second most common illness diagnosed in children. However, the diagnosis can be challenging, particularly in pediatric patients. Otitis media is commonly over-diagnosed and over-treated and has been identified as one of the primary factors in increased antibiotic resistance. We describe the development of a short-wave infrared (SWIR) otoscope for objective middle ear effusion diagnosis. The SWIR otoscope can unambiguously detect the presence of middle ear fluid based on its strong light absorption in the SWIR. This absorption causes a stark, visual contrast between the presence and absence of fluid behind the tympanic membrane. Additionally, when there is no middle ear fluid, the deeper tissue penetration of SWIR light allows the SWIR otoscope to better visualize middle ear anatomy through the tympanic membrane than is possible with visible light. We demonstrate that in healthy, adult human ears, SWIR otoscopy can image a range of middle ear anatomy, including landmarks of the entire ossicular chain, the promontory, the round window niche, and the chorda tympani. We suggest that SWIR otoscopy can provide valuable diagnostic information complementary to that provided by visible pneumotoscopy in the diagnosis of middle ear effusions, otitis media, and other maladies of the middle ear.
Towards automatic generation of natural language generation systems (2002)

Systems that interact with the user via natural language are in their infancy. As these systems mature and become more complex, it would be desirable for a system developer if there were an automatic method for creating natural language generation components that can produce quality output efficiently. We conduct experiments that show that this goal appears to be realizable. In particular we discuss a natural language generation system that is composed of SPoT, a trainable sentence planner, and FER-GUS, a stochastic surface, realizer. We show how these stochastic NLG components can be made to work together, that they can be ported to new domains with apparent ease, and that such NLG components can be integrated in a real-time dialog system.
134 Long-Term Deutetrabenazine Treatment Is Associated with Sustained Treatment Response in Tardive Dyskinesia: Results from an Open-Label Extension Study (2020)

Abstract: Background: In the 12-week ARM-TD and AIM-TD studies evaluating deutetrabenazine for the treatment of tardive dyskinesia (TD), the percentage of patients achieving ≥50% response was higher in the deutetrabenazine-treated group than in the placebo group. These studies also showed low rates of overall adverse events (AEs) and discontinuations associated with deutetrabenazine. The current open-label study evaluated the long-term efficacy and safety of deutetrabenazine in patients with TD. Methods: Patients with TD who completed ARM-TD or AIM-TD could enroll in this open-label, single-arm extension study, titrating up over 6 weeks to a maximum total daily dose of deutetrabenazine 48 mg/day on the basis of dyskinesia control and tolerability. The proportion of Abnormal Involuntary Movement Scale (AIMS; items 1-7) responders was assessed based on response rates for achieving ≥50% improvement from baseline in the open-label extension study. AlMS score was assessed by local site raters for this analysis. Results: 343 patients enrolled in the extension study. At Week 54 (n=249; total daily dose [mean ± standard error]: 38.6±0.66 mg), the mean percentage change from baseline in AIMS score was –40%; 48% of patients achieved a ≥50% response and 59% of those had already achieved a ≥50% response at Week 15. Further, 34% of those who had not achieved a ≥50% response at Week 15 achieved a ≥50% response at Week 54. At Week 106 (n=169; total daily dose: 39.6±0.77 mg), the mean percentage change from baseline in AIMS score was –45%; 55% of patients achieved a ≥50% response, 59% of those patients had already achieved a ≥50% response at Week 15, and 41% of those who had not achieved a ≥50% response at Week 15 but who reached Week 106 achieved a ≥50% response. At Week 132 (n=109; total daily dose: 39.7±0.97 mg), the mean percentage change from baseline in AIMS score was –61%; 55% of patients achieved a ≥50% response, 61% of those patients had already achieved a ≥50% response at Week 15, and 43% of those who had not achieved a ≥50% response at Week 15 but who reached Week 132 achieved a ≥50% response. Completer analysis suggests that long-term efficacy was not due to dose increases over time. Treatment with deutetrabenazine was generally well tolerated. There were 623 patient-years of exposure through Week 158, and exposure-adjusted incidence rates (incidence/patient-years) of adverse events of special interest were 0.01 for akathisia and restlessness, 0.07 for somnolence and sedation, 0.04 for parkinsonism, and 0.05 for depression. Conclusions: Patients who received long-term treatment with deutetrabenazine achieved response rates that were indicative of clinically meaningful long-term benefit. Results from this open-label trial suggest the possibility of increasing benefit over time with individual dose titration of deutetrabenazine. Funding Acknowledgements: This study was funded by Teva Pharmaceuticals, Petach Tikva, Israel.
Lightweight automatic face annotation in media pages (2012)

Labeling human faces in images contained in Web media stories enables enriching the user experience offered by media sites. We propose a lightweight framework for automatic image annotation that exploits named entities mentioned in the article to significantly boost the accuracy of face recognition. While previous works in the area labor to train comprehensive offline visual models for a pre-defined universe of candidates, our approach models the people mentioned in a given story on the y, using a standard Web image search engine as an image sampling mechanism. We overcome multiple sources of noise introduced by this ad-hoc process, to build a fast and robust end-to-end system from off-the-shelf error-prone text analysis and machine vision components. In experiments conducted on approximately 900 faces depicted in 500 stories from a major celebrity news website, we were able to correctly label 81.5% of the faces while mislabeling 14.8% of them.
Microelectromechanical tunable long wavelength vertical-cavity semiconductor optical amplifiers (2005)

We present the first demonstration of a microelectromechanical tunable vertical-cavity semiconductor optical amplifier. Electrostatic deflection of the membrane DBR structure has resulted in tunable amplification over an 11-nm wavelength range (1580-1569 nm), with a peak device gain of 17 dB.
Development of a Low Noise Pulse Combustor (1987)

Abstract A low noise pulse combustor has been developed based on experiments. Combustion noise has been reduced by dividing the heat input into two equal quantities and burning them with two small burners. When the two pulse burners whose combustion frequencies were slightly different were operated side by side, an annoying beating occurred. The beat was suppressed by bringing two burners into synchronized combustion. This was achieved by a new construction which included a communicating passage between two exhaust decouplers to allow the pressures in them to interact on each other. The construction was simple, but it was confirmed by experiments that the means offered a reliable way to synchronize multiple pulse combustions. It was found that the pulse combustion noise as a noise source could be reduced by 6.5 dB applying this construction to a two-burner combustor.
Sonar detection performance improvement using embedded watermark (2011)

Embedding of a digital watermark in a sonar waveform has been recently proposed. The detection of the watermark is subsequently used for identification and authentication. Generally, a matched filter receiver is used for the detection of unmarked pulses. However, if the pulse carries a watermark we can exploit the knowledge of the watermark to improve the detection rate of the sonar pulse itself. This operation takes place in the proposed joint detector. If the received pulse is unmarked, we show that the detection rate is virtually identical to the matched filter receiver.
Direct Analysis of Aerosolized Chemical Warfare Simulants Captured on a Modified Glass-Based Substrate by “Paper-Spray” Ionization (2017)

Paper spray ionization mass spectrometry offers a rapid alternative platform requiring no sample preparation. Aerosolized chemical warfare agent (CWA) simulants trimethyl phosphate, dimethyl methylphosphonate, and diisopropyl methylphosphonate were captured by passing air through a glass fiber filter disk within a disposable paper spray cartridge. CWA simulants were aerosolized at varying concentrations using an in-house built aerosol chamber. A custom 3D-printed holder was designed and built to facilitate the aerosol capture onto the paper spray cartridges. The air flow through each of the collection devices was maintained equally to ensure the same volume of air sampled across methods. Each approach yielded linear calibration curves with R<sup>2</sup> values between 0.98-0.99 for each compound and similar limits of detection in terms of disbursed aerosol concentration. While the glass fiber filter disk has a higher capture efficiency (≈40%), the paper spray method produces analogous results even with a lower capture efficiency (≈1%). Improvements were made to include glass fiber filters as the substrate within the paper spray cartridge consumable. Glass fiber filters were then treated with ammonium sulfate to decrease chemical interaction with the simulants. This allowed for improved direct aerosol capture efficiency (>40%). Ultimately, the limits of detection were reduced to levels comparable to current worker population limits of 1 × 10<sup>-6</sup> mg/m<sup>3</sup>.
Four Intuitive Messages for LDPC Codes (2007)

Four new messages for decoding of low-density parity-check (LDPC) codes are proposed. An a posteriori probability ratio (APPR) message, an a posteriori probability (APP) message, and an a posteriori probability difference (APPD) message for variable and check nodes are derived for sum-product decoding of LDPC codes. Also, we propose a hybrid APPD-APPR message, which denotes a hybrid message with an APPD variable node message and APPR check node message. All the proposed messages require only addition, subtraction, multiplication, and division operations for decoding of LDPC codes. We show that the hybrid APPD-APPR message-passing has the lowest complexity among the proposed messages.
A method of generating atmospheric turbulence with a liquid crystal spatial light modulator (2010)

The Naval Research Laboratory has developed a new method for generating atmospheric turbulence and a testbed that simulates its aberrations far more inexpensively and with greater fidelity using a Liquid Crystal (LC) Spatial Light Modulator (SLM) than many other methods. This system allows the simulation of atmospheric seeing conditions ranging from very poor to very good and different algorithms may be easily employed on the device for comparison. These simulations can be dynamically generated and modified very quickly and easily. In addition, many models for simulating turbulence often neglect temporal transitions along with different seeing conditions. Using the statistically independent set of Karhunen-Loeve polynomials in conjunction with Kolmogorov statistics in this model provides an accurate spatial and temporal model for simulating turbulence. An added benefit to using a LC SLM is its low cost; and multiple devices can be used to simulate multiple layers of turbulence in a laboratory environment. Current testing with using multiple LC SLMs is under investigation at the Naval Research Laboratory and the Naval Postgraduate School.