gebhart/patrepeval huggingface dataset:
LNGFR+THY-1+VCAM-1hi+ Cells Reveal Functionally Distinct Subpopulations in Mesenchymal Stem Cells (2013)

Human mesenchymal stem cells (hMSCs), which conventionally are isolated based on their adherence to plastic, are heterogeneous and have poor growth and differentiation, limiting our ability to investigate their intrinsic characteristics. We report an improved prospective clonal isolation technique and reveal that the combination of three cell-surface markers (LNGFR, THY-1, and VCAM-1) allows for the selection of highly enriched clonogenic cells (one out of three isolated cells). Clonal characterization of LNGFR(+)THY-1(+) cells demonstrated cellular heterogeneity among the clones. Rapidly expanding clones (RECs) exhibited robust multilineage differentiation and self-renewal potency, whereas the other clones tended to acquire cellular senescence via P16INK4a and exhibited frequent genomic errors. Furthermore, RECs exhibited unique expression of VCAM-1 and higher cellular motility compared with the other clones. The combination marker LNGFR(+)THY-1(+)VCAM-1(hi+) (LTV) can be used selectively to isolate the most potent and genetically stable MSCs.
Liver Tumors: MR Imaging of Radioactive Holmium Microspheres—Phantom and Rabbit Study (2004)

Ho-PLLA-MS used for internal radionuclide therapy can be imaged clearly in vivo with MR imaging.
Automated Middleware QoS Configuration Techniques for Distributed Real-time and Embedded Systems (2008)

Quite often the modeling tools used in the development lifecycle of distributed real-time and embedded (DRE) systems are middleware-specific, where they elevate middleware artifacts, such as configuration options, to first class modeling entities. Unfortunately, this level of abstraction does not resolve the complex issues in middleware configuration process for QoS assurance. This paper describes GT-QMAP (graph transformation for QoS mapping) model-driven engineering toolchain that combines (1) domain-specific modeling, to simplify specifying the QoS requirements of DRE systems intuitively, and (2) model transformations, to automate the mapping of domain-specific QoS requirements to middleware-specific QoS configuration options. The paper evaluates the automation capabilities of GT-QMAP in the context of three DRE system case studies. The results indicate that on an average the modeling effort is reduced by over 75%. Further, the results also indicate that GT-QMAP provides significant benefits in terms of scalability and automation as DRE system QoS requirements evolve during its entire development lifecycle.
Effects of Meandering on Dipole Antenna Resonant Frequency (2012)

In low-frequency applications, antenna designers find that it is beneficial to adjust the resonant frequency while preferably maintaining the physical size as a means of improving the antenna's radiation resistance, which in turn improves the radiation efficiency. The closer the resonant frequency is to the frequency of operation, the more efficient the antenna is. Addition of bends is one such technique for increasing the electrical size of a dipole antenna while maintaining the same overall physical length. This letter presents a study of the effects of bends on the resonant frequency of a dipole antenna in the VHF frequency range. A broadband equivalent circuit model for a straight dipole from previous work is adapted to a three-bend meander dipole antenna, and its performance is compared to that of a straight dipole having the same overall physical length. The predicted frequency response of the broadband model is calculated using circuit simulation software and compared to results from computational electromagnetic modeling and network-analyzer measurement of prototype straight and meandered dipole antennas.
Stem Cell Marker OCT3/4 in Tumor Biology and Germ Cell Tumor Diagnostics: History and Future (2006)

The transcription factor OCT3/4 (also known as POU5F1 and Oct4) is regarded as one of the key regulators of pluripotency. Expression in nonmalignant cells is restricted to the pluripotent cells in the embryo and the primordial germ cells that will pass pluripotency to future generations via the gametes. Although major progress has been made in successfully identifying other players in the pluripotency network by using high-throughput screening methods, the exact mechanisms involved in regulation of OCT3/4 in vivo remain largely to be elucidated. In human tumors, OCT3/4 is the most informative marker in germ cell tumors diagnostics and is expressed in the precursor lesions gonadoblastoma and carcinoma in situ, as well as in invasive embryonal carcinoma and seminomatous tumors. Currently, the application of OCT3/4 for screening in high-risk patient populations is the novel focus of study. This article reviews OCT3/4 expression in normal development and germ cell tumors. In addition, expression in adult tissues and nongerm cell tumor malignancies in relation to splice variants and pseudogenes is discussed. An overview of the upstream and downstream factors in the OCT3/4 pathway as well as the epigenetic regulation of the gene is summarized and the possible role in oncogenesis considered.
Bence Jones proteins bind to a common peptide segment of Tamm-Horsfall glycoprotein to promote heterotypic aggregation. (1993)

Bence Jones proteins (BJPs) are the major pathogenic factor causing cast nephropathy ("myeloma kidney") by coaggregation with Tamm-Horsfall glycoprotein (THP). Understanding the interaction between these proteins is therefore important in developing treatment strategies to prevent renal failure from cast formation in multiple myeloma. We developed an enzyme-linked immunoassay to examine this phenomenon. Five different human BJPs (four kappa and one lambda immunoglobulin light chains) were used in this assay that demonstrated these proteins bound THP with different affinity. BJPs competed among themselves for binding to THP. The binding site was a peptide portion of THP since these proteins also bound deglycosylated THP. Also, one monoclonal antibody directed against a peptide segment of human THP prevented binding of THP to BJPs. By altering the conformation of THP, reducing agents decreased binding between these two proteins in concentration-dependent fashion. In turbidity studies, the monoclonal antibody that prevented binding and a reducing agent, dithiothreitol, decreased coaggregation. Deglycosylated THP did not coaggregate with BJPs. We concluded that ionic interaction between BJPs and a specific peptide binding site on THP promoted heterotypic coaggregation. The carbohydrate moiety of THP was also essential for coaggregation, perhaps by facilitating homotypic aggregation of THP.
Design, fabrication, and performance of spin-valve read heads for magnetic recording applications (1998)

Since the early 1990s, the introduction of dual-element recording heads with inductive write elements and magnetoresistive (MR) read elements has almost doubled the rate of areal density improvements for hard-disk-drive data storage products. In the past several years, prospects of even more rapid performance improvements have been made possible by the discovery and development of sensors based on the giant magnetoresistance (GMR) effect, also known as the spin-valve effect, for a particular class of sensor configurations. In this paper, we explore the potentials as well as challenges of spin-valve sensors as magnetic recording read heads. We first examine the data rate and areal density potentials of large read-back signals resulting from increases in the MR coefficient. We then discuss associated magnetic sensor performance, including linearity and noise suppression. Finally, we study in detail the magnetic and recording performance of a spin-valve read head designed for 1-Gb/in. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> density performance.
Photoablation of Human Vitreous Opacities by Light-Induced Vapor Nanobubbles (2019)

Myopia, diabetes, and aging are the main causes of progressive vitreous collagen aggregation, resulting in vitreous opacities, which can significantly disturb vision. As vitreous opacities, which induce the visual phenomenon of "floaters", are accessible with nanomaterials and light, we propose a nanotechnology-based approach to locally ablate them with highly reduced light energy compared to the more traditional YAG laser therapy. Our strategy relies on the plasmon properties of gold nanoparticles that generate vapor nanobubbles upon pulsed-laser illumination whose mechanical force can ablate vitreous opacities. We designed gold nanoparticles coated with hyaluronic acid (HA), which have excellent diffusional mobility in human vitreous, an essential requirement to reach the vitreous opacities. In addition, we found that HA-coated gold nanoparticles can accumulate extensively on human vitreous opacities that were obtained by vitrectomy from patients with vision-degrading myodesopsia. When subsequently applying nanosecond laser pulses, the collagen aggregates were efficiently destroyed with ∼1000 times less light energy than typically used in YAG laser therapy. This low-energy "floater-specific destruction", which is due to the accumulation of the small gold nanoparticles on the opacities, is attractive, as it may be safer to the surrounding ocular tissues while at the same time being easier and faster to apply compared to YAG laser therapy, where the opacities need to be ablated piece by piece by a tightly focused laser beam. Gold nanoparticle-assisted photoablation may therefore provide a safer, faster, and more reliable destruction of vitreous opacities in the treatment of ophthalmologic diseases.
Communication—Effect of Lithium Polysulfide Solubility on Capacity of Lithium-Sulfur Cells (2017)

Understanding the behavior of lithium (Li)-sulfur (S) cells under lithium polysulfide (LiPS)-saturated condition, especially determining whether LiPS solubility is an intrinsic limit for cell capacity, is of great interest for the development of high energy density Li-S batteries. In this work, sets of Li-S cells were tested under designed scenarios to demonstrate the effect of LiPS solubility on cell capacity. It revealed that when LiPS solubility limit is reached, though sulfur can be reduced to solid state LiPS, it cannot further convert to subsequent discharge products and contribute to cell capacity.
Recent Discovery of PARP7 Inhibitors as Anticancer Agents (2022)

The 5-year survival rate for advanced ovarian cancer remains less than 30% and has not improved in recent years. Disclosures in this patent highlight provides PARP7 inhibitors and methods for treating cancers such as ovarian cancer and pancreatic cancers.
Screening Large‐Insert Libraries by Hybridization (1999)

Abstract Three types of hybridization screening are discussed in this unit colony hybridization, DNA hybridization, and YAC Alu‐PCR‐product hybridization. The first protocol describes methods for arraying large‐insert clones. Subsequent protocols discuss hybridizing YAC and BAC/PAC colony blots. An alternate protocol provides a guide for preparing and hybridizing with, high‐specific‐activity oligonucleotide probes called “overgo” probes. Support protocols indicate the procedures for identifying the plate and well address of positive clones by manual and software‐assisted methods. Hybridization of Alu‐PCR‐product probes to Alu‐PCR products of YAC clones are provided. An alternate protocol describes a method for preparing DNA from individual YACs and for producing and using Alu‐PCR product blots from individual YACs. Additional support protocols provide guidelines for preparing Alu‐PCR probes from cosmids, YACs, BACs/PACs, and somatic cell hybrids, and describe the use of 96‐well plates to radiolabel and spin‐column‐purify large numbers of probes. A method for YAC walking is also provided.Three types of hybridization screening are discussed in this unit colony hybridization, DNA hybridization, and YAC Alu‐PCR.
Immunity to Reinfection and Immunization of Male Guinea Pigs Against Urethral Infection With the Agent of Guinea Pig Inclusion Conjunctivitis (1996)

Male guinea pigs possess protective mechanisms that make them more resistant to repeat chlamydial genital infection for a longer period of time than is seen in female guinea pigs. In addition, immunization of males with inactivated chlamydial antigen by a parenteral route is able to elicit a protective response to urethral infection with chlamydiae.
Miguel Ángel Silvestre. (2006)

Tras su paso por la serie de television Motivos personales y una colaboracion en Vida y color, de Santiago Tabernero, el actor castellonense de 24 anos afronta su primer papel protagonista en LA DISTANCIA, del realizador Inaki Dorronsoro. Silvestre, a quien el vacio que le dejo su sueno frustrado de ser tenista profesional le acerco a la interpretacion, da vida a Daniel, un boxeador con anhelos de redencion que se ve inmerso en su trama de corrupcion policial.
The genetics of diabetes susceptibility in mice (1989)

The factors associated with a diabetes-susceptible genotype in mice exhibiting various forms of heritable glucose intolerance syndromes are discussed. Genetic models of insulin-dependent and non-insulin-dependent diabetes in mice are described. Although single gene mutations can be defined for each model that are major contributors to diabetogenic stress, polygenic interactions are required for the expression of a diabetic phenotype, and environmental factors are also contributory. Several strongly penetrant single gene mutations are capable of affecting obesity and insulin-resistant states. Analysis of inbred strain genomic interactions with one of these recessive obesity-producing genes, diabetes (db), suggests that development of a diabetic phenotype is dependent on the strength of an interaction between the db gene and sulfotransferase enzymes. Specifically, diabetes-susceptible vs. resistant inbred strain backgrounds can be distinguished by the extent to which the db mutation elicits an accelerated sequestration by sulfoconjugation of tissue estrogens while androgens remain free. In a male gender- (and Y chromosome-)associated model of transient glucose intolerance, stress as well as a requirement for both adrenal and testicular secretions are each components of the susceptibility background. In the obesity-associated diabetes models, autoimmunity, when it occurs, is a secondary reflection of pancreatic beta cell destruction. The nonobese diabetic (NOD) mouse, in contrast, represents a model in which autoimmunity against beta cells is a primary event in the development of insulin-dependent diabetes. In NOD mice, a gene that is either the unique class II gene in the major histocompatibility complex or is in linkage disequilibrium with this complex makes a major (recessivelike) contribution to diabetes susceptibility. However, diabetogenesis can be mediated only through a multifactorial interaction among this susceptibility locus and multiple unlinked genetic loci regulating immune responsiveness. In addition, the NOD mouse represents one of the best models of diabetes available for demonstrating a critical interaction between heredity and environmental factors. The polygenic nature of the various heritable forms of glucose intolerance syndromes in mice points to a comparable or even greater genetic heterogeneity underlying the major types of diabetes in humans.
Distance-based Confidence Score for Neural Network Classifiers (2017)

The reliable measurement of confidence in classifiers' predictions is very important for many applications and is, therefore, an important part of classifier design. Yet, although deep learning has received tremendous attention in recent years, not much progress has been made in quantifying the prediction confidence of neural network classifiers. Bayesian models offer a mathematically grounded framework to reason about model uncertainty, but usually come with prohibitive computational costs. In this paper we propose a simple, scalable method to achieve a reliable confidence score, based on the data embedding derived from the penultimate layer of the network. We investigate two ways to achieve desirable embeddings, by using either a distance-based loss or Adversarial Training. We then test the benefits of our method when used for classification error prediction, weighting an ensemble of classifiers, and novelty detection. In all tasks we show significant improvement over traditional, commonly used confidence scores.
Analysis of homonuclear RF gradient NMR spectroscopy (1995)

Abstract A formalism for describing the spin dynamics of radio frequency (RF) gradient experiments is introduced. It has the advantage over the most straight-forward applications of product operator methods of cleanly separating the steps of coherence transformation and gradient evolution which become confused in many RF gradient methods. The analysis is used to explore the dynamics of RF gradient homonuclear multiple quantum filtering experiments. Experimental results of these new sequences are included.
Challenges for ion implantation (2002)

We review the many challenges that lie ahead for ion implantation. Continued device scaling requires the formation of ever-shallower, low-resistivity junctions. Recent trends in conventional implant and RTA processing, such as the use of ultra-low energy implants and spike anneals, allow these technologies to continue to be used for the formation of ultra-shallow junctions that meet the ITRS requirements for at least the 70 nm node. Successful fabrication of sub-100 nm devices will also require an understanding of the use of species such as indium and antimony for ultra-precise dopant placement. There will be an expanded use of high energy implantation. Applications here include triple well isolation for memory structures, and buried layer implants for W gettering. We discuss non-traditional applications of ion implantation. These include implants for the fabrication of SOI materials and implants into vertical device structures. We conclude with a discussion of the implications of these technologies on the future of the ion implantation business.
Three-Dimensional Observation of the Conductive Filament in Nanoscaled Resistive Memory Devices (2014)

The basic unit of information in filamentary-based resistive switching memories is physically stored in a conductive filament. Therefore, the overall performance of the device is indissolubly related to the properties of such filament. In this Letter, we report for the first time on the three-dimensional (3D) observation of the shape of the conductive filament. The observation of the filament is done in a nanoscale conductive-bridging device, which is programmed under real operative conditions. To obtain the 3D-information we developed a dedicated tomography technique based on conductive atomic force microscopy. The shape and size of the conductive filament are obtained in three-dimensions with nanometric resolution. The observed filament presents a conical shape with the narrow part close to the inert-electrode. On the basis of this shape, we conclude that the dynamic filament-growth is limited by the cation transport. In addition, we demonstrate the role of the programming current, which clearly influences the physical-volume of the induced conductive filaments.
Normalization and Matching in the DORO System (1999)

This paper is concerned with the use of linguistically motivated phrases as indexing terms in Information Retrieval applications. Apart from the conventional noun phrases, we propose to use verb phrases as index terms for text classification. Techniques for phrase matching through syntactic normalization and semantical matching are described. We discuss the realization of the syntactic normalization of phrases by transduction to frames. Semantical normalization is based on lexico-semantical relations, taking into account certain properties of the classification algorithms used. The ideas described here are being implemented in the Document Routing system DORO, in which statistical learning algorithms are applied to document profiles consisting of phrases. This paper describes the rationale behind work in progress, rather than presenting final results.
A new p-channel MOSFET structure with Schottky-clamped source and drain (1984)

New p-channel Schottky-Clamped MOSFET'S (SCMOSFET'S) whose source and drain junctions are composed of PtSi Schottky diodes shunted with very small p-n diodes are proposed. The proposed transistors can be fabricated either by silicon V-groove etching or by using boron-doped sidewall oxides. The proposed devices take full advantages of the p-channel Schottky MOSFET while eliminating the problems associated with the Schottky source/drain region, such as low breakdown voltages, high leakage current and a significant reduction of drain current. Moreover, SCMOSFET's reduce the latchup sensitivity in CMOS circuits without any significant increase in technological complexity.
<title>Telemanufacturing workcell over the Internet</title> (1998)

A workcell environment consisting of a robot and image acquisition system is et up for control over the Internet. The first phase of the project explores supervisory control of the workcell through the use of CGI, a standard for external gateway programs to interface with HTTP servers. Robot motion consists of movement to preprogrammed points and limited fine motion in 3 axes. Supervisory control is also extended to programming a series of motions for a robot to follow through. The current phase of the project abandons the use of CGI and the batch oriented regime of workcell control. A protocol is developed for the end-user interface program to communicate with a workcell server directly. Commands are sent to the server which in turn directs the robot to perform the associated motion.The workcell server also provides information for end-user interface programs to generate a 3D model of the robot setup. A separate HTTP- based video feedback system dispatches images to workcell supervisors. The work here provides basis on which to build a more general protocol for Internet control of not only robots but also other devices. A component approach towards building the workcell allows for hardware independence and the ease of integration of other elements of feedback.
Bio-nanocomposite Materials for Food Packaging Applications: Types of Biopolymer and Nano-sized Filler (2014)

Majority of materials employed for food packaging are non-biodegradable materials which do not meet increasing demands in society for sustainability and environmental safety. Thus, numerous biopolymers have been exploited to develop biodegradable food packaging materials. Nonetheless, the usage of biopolymers has been limited due to the poor mechanical and barrier properties. These properties can be enhanced by adding reinforcing nano-sized compounds or fillers to form composites. This article reviews variety types of biopolymer and nano-sized filler used to form bio-nanocomposite materials.