gebhart/patrepeval huggingface dataset:
Bioelectrical Stimulation for the Reduction of Inflammation in Inflammatory Bowel Disease (2015)

Crohn's disease and ulcerative colitis are the primary inflammatory bowel diseases (IBDs) affecting the gastrointestinal tract. The current therapy aims at decreasing inflammation and reducing symptoms. This typically requires immune suppression by steroids, thiopurines, methotrexate, or tumor necrosis factor inhibitors. Patients may be unreceptive to medical therapy, and some may discontinue the treatment due to adverse effects. Noninvasive, transcutaneous vagus nerve stimulation (VNS) is currently used as a treatment for depression and epilepsy, and it is being investigated for the treatment of conditions such as multiple sclerosis, migraines, and Alzheimer's disease. Recent studies have demonstrated the importance of splenic and vagus nerve functions in the inflammatory process through the production of certain cytokines. We hypothesize that using transcutaneous VNS via the auricular afferent branch could achieve a selective anti-inflammatory effect on the intestinal wall. This review examines the possibility of using vagal stimulators as a therapy for IBD. This could open the door to novel treatments for numerous vagally mediated diseases characterized by poor responses to current therapies.
Determination of interbar current effects in the detection of broken rotor bars in squirrel cage induction motors (1994)

In present monitoring techniques for the detection of broken rotor bars in squirrel cage induction motors, the assumption is made that a broken bar conducts no current. This causes a magnetic imbalance, which can then be detected to indicate a broken bar. In certain motors, however, large currents are still able to flow in the broken bar by means of interbar currents. This paper deals with the effects these currents have on broken bar monitoring. The work shows theoretically and experimentally that interbar currents reduce any magnetic imbalance brought about by the broken bar.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Differential DNA methylation of the <i>D4Z4</i> repeat in patients with FSHD and asymptomatic carriers (2014)

This study provides Class III evidence that assays for hypomethylation within the D4Z4 region accurately distinguish patients with FSHD from individuals with D4Z4 contraction without FSHD.
Interference of coumarin therapy with the "Heptest" owing to declining prothrombin concentrations. (1989)

The Heptest kit (Haemachem, Inc., St. Louis, MO) for quantifying heparin in plasma is based on heparin-mediated inhibition of factor Xa, resulting in prolongation of clotting time. In 19 of 55 plasma samples obtained from 32 patients concurrently receiving coumarin and heparin, Heptest results exceeded true heparin values by more than 0.2 int. unit/mL; four samples showed a deviation exceeding 0.4 int. unit/mL. We show here that these deviations are caused by coumarin-induced decreases of plasma prothrombin. This problem can be circumvented by adding purified prothrombin or normal plasma to the assay mixture.
Cold electron and ion beams generated from trapped atoms (2007)

A novel way of creating low-temperature electron and ion beams is demonstrated. The beams are generated by converting a laser-cooled atom cloud to a highly excited Rydberg gas, which subsequently develops into an ultracold plasma. Charged particles are extracted from the Rydberg gas and the plasma by a pulsed electric field. The properties of the resulting electron and ion pulses are experimentally studied. Pulses of a few hundred ns duration containing a few pC of charge were observed. Upper limits for the temperature of such beams (60K for ions and 500K for electrons) are obtained, and the beams are shown to have low emittance. Further development of the method may lead to the generation of high-brightness charged-particle beams from ultracold plasmas.
Redundant and on-line CORDIC: application to matrix triangularization and SVD (1990)

Several modifications to the CORDIC method of computing angles and performing rotations are presented: (1) the use of redundant (carry-free) addition instead of a conventional (carry-propagate) one; (2) a representation of angles in a decomposed form to reduce area and communication bandwidth; (3) the use of on-line addition (left-to-right, digit-serial addition) to replace shifters by delays; and (4) the use of online multiplication, square root, and division to compute scaling factors and perform the scaling operations. The modifications improve the speed and the area of CORDIC implementations. The proposed scheme uses efficiently floating-point representations. The application of the modified CORDIC method to matrix triangularization by Givens' rotations and to the computation of the singular value decomposition (SVD) are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Technology and Standardization Gaps for High Accuracy Positioning in 5g (2017)

The next generation mobile networks (5G) is about to introduce many new functionalities that will enable a portfolio of new services and applications to the benefit of the end user. One such functionality is positioning, which is a sought-after service especially for mobile network operators as location-based services is a massive market opportunity. To reach the goal of having the infrastructure ready for positioning services by 2020, this article tries to raise the awareness of the main technology and standardization gaps. One such gap concerns accurate and precise time synchronization, as one of the best telecom-based positioning technologies requires the mobile base stations to be synchronized to nanoseconds relative to each other. On top of that, the evolution of LTE and 5G will introduce a broad portfolio of new technology trends and concepts that will have a significant impact on the overall mobile network architecture and therefore will affect the traditional positioning concepts as well. Hence, the focus of this article is further extended to new technology trends that are directly related to the positioning functionality and are planned for broad deployment in the near future, or widely recognized to be essential for 5G, such as massive MIMO (mMIMO), mmWave, and dense small cell deployment.
Assessing stability and assembly of the hepatitis B surface antigen into virus-like particles during down-stream processing (2015)

The hepatitis B surface antigen (HBsAg) is a recombinant protein-based vaccine being able to form virus-like particles (VLPs). HBsAg is mainly produced using yeast-based expression systems, however, recent results strongly suggest that VLPs are not formed within the yeast cells during the cultivation but are formed in a gradual manner during the following down-stream procedures. VLPs are also not detectable during the first down-stream steps including mechanical and EDTA/detergent-assisted cell destruction. Moreover, VLPs are not detectable in the cell lysate treated with polyethylene glycol and colloidal silica. The first VLP resembling structures appear after elution of HBsAg from colloidal silica to which it binds through hydrophobic interaction. These first VLP resembling structures are non-symmetrical as well as heterodisperse and exhibit a high tendency toward cluster formation presumably because of surface exposed hydrophobic patches. More symmetrical and monodisperse VLPs appear after the following ion-exchange and size-exclusion chromatography most likely as the result of buffer changes during these purification steps (toward more neutral pH and less salt). Final treatment of the VLPs with the denaturant KSCN at moderate concentrations with following KSCN removal by dialysis does not cause unfolding and VLP disassembly but results in a re- and fine-structuring of the VLP surface topology.
Microcontroller managed module for automatic ventilation of vehicle interior (2014)

In order to mitigate overheated interior of a vehicle parked in the hot summer sun and thereby to make the entering into the vehicle more comfortable, microcontroller managed module for automatic ventilation of vehicle interior is made. The module is implemented using a microcontroller as a central logical unit and a series of sensors which provide sufficient data to ensure functional, but also efficient, reliable and safe ventilation. The ventilation process is performed by opening vehicle windows slightly, which enables air to circulate. Microcontroller controls the position of the windows autonomously and independently of the driver's presence, following predefined algorithm that uses sensors data obtained from the vehicle's surroundings. Besides temperature, the most important factors to ensure quality implementation of ventilation are detected movements around the vehicle, the presence of precipitation and other. This paper shows the components, their purpose and capabilities, advantages and disadvantages, as well as potential implementations and upgrades. The test results give insight into utilization options of this module and its usefulness.
Homology of lipoprotein lipase to pancreatic lipase. (1986)

Bovine milk lipoprotein lipase was subjected to amino acid sequence analysis. The first 19 amino-terminal residues were Asp-Arg-Ile-Thr-Gly-Gly-Lys-Asp-Phe-Arg-Asp-Ile-Glu-Ser-Lys-Phe-Ala-Leu- Arg. In addition, reversed-phase high-performance liquid chromatography of a tryptic digest of reduced and alkylated lipase resolved a number of peptides, five of which contained cysteine. Sequence analysis of the tryptic peptides revealed in most instances a close homology to porcine pancreatic lipase. Based on this homology, the relative alignment of the sequenced lipoprotein lipase peptides can be made. In addition, a potential binding site for the triacylglycerol substrate and a carbohydrate-binding domain for lipoprotein lipase are postulated.
Microneurography in relation to intraneural topography: somatotopic organisation of median nerve fascicles in humans. (1990)

Microneurography was performed in median nerve sensory fascicles with concentric needle electrodes and with conventional tungsten microneedles. The latter electrodes preferentially recorded activity from the myelinated fibres in the whole fascicle. By contrast, due to its special design, a concentric needle can record activity selectively from even a small part of a fascicle. High amplitude signals in C fibres can be discriminated close to Schwann cells that envelope unmyelinated axons. Apart from being biased for activity in thin fibres, the concentric needles can also record signals from nearby myelinated fibres. The palmar receptive fields of such fibre groups were not congruent with the areas traditionally attributed to multiunit skin afferents in humans, namely the innervation zone(s) of one or two adjacent digital nerve(s). Instead, the multiunit fields often comprised small parts of a digital nerve innervation area, frequently only the pulp of a finger. Single units were always localised within previously screened multiunit areas. Contrary to some previously accepted tenets it is probable that single unit activity in myelinated fibres in these studies is recorded extra-axonally near to a node of Ranvier. The findings also suggest the presence of a somatotopy in human limb nerve fascicles, comparable to that previously established in the spinal cord and the somatosensory cortex.
Laboratory studies on enhancement of granulation in the anaerobic sequencing batch reactor (1997)

The phenomenon of granulation was studied in anaerobic sequencing batch reactors (ASBRs) treating a synthetic sucrose wastewater. The objective was to study methods of minimizing the time typically required for start-up of high rate anaerobic processes, such as the ASBR, when utilizing biomass from typical anaerobic digesters. More specifically, the goal was to develop granular biomass soon after initial start-up of the ASBR in order to decrease the overall time required to achieve high rate anaerobic treatment. Laboratory-scale ASBRs were seeded with anaerobically digested municipal biosolids and operated until granulation was observed. Granule development was measured by determination of the average particle diameter of a representative sample of biosolids from the ASBRs. Cationic polymer was added to the test ASBR to enhance rapid granule development and to aid in start-up. Cationic polymer addition reduced the time required to form granules by approximately 75 % compared to an un-enhanced control ASBR.
Reactive Oxygen Species (ROS) mediated degradation of organophosphate pesticides by the green microalgae Coccomyxa subellipsoidea (2020)

The aim of this study was to define the mechanism allowing the green alga Coccomyxa subellipsoidea to break down organophosphates from agricultural run-off. This study found that metabolically active cultures of the microalga C. subellipsoidea breakdown organophosphates (paraoxon, malathion and diazinon) with differing structural conformations in freshwater through a mechanism that requires the formation of reactive oxygen species (ROS) with little to no toxic effects on the algae. Under these conditions, organophosphate levels were reduced to 0.1 mg/mL or less over the 8–10 day experimental period. These findings demonstrate a biological-based system can be tailored for the remediation of organophosphates from agricultural run-off in waterways for long-term sustainability that also includes bioproduct development from the algal biomass. These finding are expected to have significant impacts using this biological based technology for the remediation of organophosphates in water for downstream applications.
Asymmetric Aldol Type Reactions of Acetate Imide Enolates (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric Aldol Type Reactions of Acetate Imide EnolatesTu-Hsin Yan, An-Wei Hung, Hui-Chun Lee, Chii-Shin Chang, and Wen-Hung LiuCite this: J. Org. Chem. 1995, 60, 11, 3301–3306Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/jo00116a011https://doi.org/10.1021/jo00116a011research-articleACS PublicationsRequest reuse permissionsArticle Views532Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
The Organelle Genome Database Project (GOBASE) (1998)

The taxonomically broad organelle genome database (GOBASE) organizes and integrates diverse data related to organelles (mitochondria and chloroplasts). The current version of GOBASE focuses on the mitochondrial subset of data and contains molecular sequences, RNA secondary structures and genetic maps, as well as taxonomic information for all eukaryotic species represented. The database has been designed so that complex biological queries, especially ones posed in a comparative genomics context, are supported. GOBASE has been implemented as a relational database with a web-based user interface (http://megasun.bch.umontreal.ca/gobase/gobas e.html ). Custom software tools have been written in house to assist in the population of the database, data validation, nomenclature standardization and front-end design. The database is fully operational and publicly accessible via the World Wide Web, allowing interactive browsing, sophisticated searching and easy downloading of data.
Coaxial-fed dual-layer SIW horn antenna with improved E-plane radiation pattern (2017)

A novel technique is introduced to improve the directivity of the E-plane pattern of substrate integrated waveguide (SIW) horn antennas. While the H-plane directivity of a SIW horn antenna is good, SIW horns have a wide E-plane radiation pattern due to the thin substrates of SIW circuits. Increasing the substrate height to improve the E-plane half power beam width (HPBW) makes it difficult to fabricate vias by current technologies. As a solution, two identical SIW horns are stacked to increase the E-plane profile of the antenna. A hole with diameter of 0.35 mm is incorporated in the substrate to accommodate a coaxial feeding port. The designed antenna has a 10-dB bandwidth of 5.37 percent and a gain of 10.33 dB at 21.5 GHz. The robustness of the design approach is validated by measurements which are in good agreement with simulations.
Atomic force microscopy under liquid: A comparative study of three different AC mode operations (1995)

Summary The image contrast mechanism of three newly proposed AC mode operations under liquid in three different frequency ranges is presented. They all rely on a strong repulsive force to damp the cantilever and the tip still ‘touches’ the sample surface. A direct comparison of the three different modes of operation with the conventional DC mode technique using the same gold sample under isopropanol was conducted. It was found that all the three AC modes exerted a much smaller lateral force than the DC mode although the normal loads were of the same order of magnitude. The suitability of such techniques in imaging physisorbed systems on hard substrates (such as soft biological samples) and the prospect of a true non‐contact repulsive mode operation are discussed.
A Brain–Computer Interface-Based Vehicle Destination Selection System Using P300 and SSVEP Signals (2014)

In this paper, we propose a novel driver-vehicle interface for individuals with severe neuromuscular disabilities to use intelligent vehicles by using P300 and steady-state visual evoked potential (SSVEP) brain-computer interfaces (BCIs) to select a destination and test its performance in the laboratory and real driving conditions. The proposed interface consists of two components: the selection component based on a P300 BCI and the confirmation component based on an SSVEP BCI. Furthermore, the accuracy and selection time models of the interface are built to help analyze the performance of the entire system. Experimental results from 16 participants collected in the laboratory and real driving scenarios show that the average accuracy of the system in the real driving conditions is about 99% with an average selection time of about 26 s. More importantly, the proposed system improves the accuracy of destination selection compared with a single P300 BCI-based selection system, particularly for those participants with relatively low level of accuracy in using the P300 BCI. This study not only provides individuals with severe motor disabilities with an interface to use intelligent vehicles and thus improve their mobility, but also facilitates the research on driver-vehicle interface, multimodal interaction, and intelligent vehicles. Furthermore, it opens an avenue on how cognitive neuroscience may be applied to intelligent vehicles.
A multicenter trial of the efficacy of nimodipine on outcome after severe head injury (1994)

Between January 1, 1989, and June 30, 1991, 852 severely head-injured patients were entered into a prospective placebo-controlled trial of the efficacy of nimodipine administration. The patients could not obey commands at the time of entry into the trial, which was within 12 hours after the start of the inability to obey commands and within 24 hours of injury. The main hypothesis that nimodipine would increase the percentage of patients with a favorable outcome (moderate disability or good recovery) from 50% to 60% was rejected. A trend toward a favorable effect was seen in patients who exhibited traumatic subarachnoid hemorrhage (SAH) on the computerized tomography (CT) scan obtained prior to entry into the study. The effect was statistically significant in those patients who complied with all protocol requirements. This finding is consistent with the effect of nimodipine on secondary ischemia following spontaneous SAH. The results of the study warrant a clinical trial of the efficacy of nimodipine in severely head-injured patients who show traumatic SAH on the initial CT scan.
OfCourse (2009)

In this paper we present OfCourse, a vertical search engine for online course materials. These materials have the following characteristics: they are scattered very sparsely in the university Web sites; and are generated by the teachers with totally different HMTL templates and layouts. These characteristics impose some challenges for Web Classification (to identify the course materials) and Web Information Extraction (to extract course metadata, such as course title, time and ID) from the identified course homepages. Here, we describe our proposed method to tackle these challenges, and the features of this system. OfCourse, containing over 60,000 courses from the top 50 universities in the US, is currently available for public access at http://fusion.hpl.hp.com/OfCourse/.
The Hamiltonian Canonical Form for Euler-Lagrange Equations (2002)

Based on the theory of calculus of variation, some suffcient conditions are given for some Euler-Lagrangcequations to be equivalently represented by finite or even infinite many Hamiltonian canonical equations. Meanwhile,some further applications for equations such as the KdV equation, MKdV equation, the general linear Euler Lagrangeequation and the cylindric shell equations are given.