gebhart/patrepeval huggingface dataset:
Noncanonical Regulation of the Hedgehog Mediator <i>GLI1</i> by c-MYC in Burkitt Lymphoma (2013)

Although Hedgehog signaling plays a major role in GLI1 transcription, there is now evidence suggesting that other pathways/genes, such as c-MYC, may also regulate GLI1 expression. We initiated studies in Burkitt lymphoma cells, which constitutively express c-MYC due to a chromosomal translocation, to determine whether Hedgehog or c-MYC regulates GLI1 expression. We show that all Burkitt lymphoma cell lines tested express GLI1, PTCH1, and SMO and that five of six Burkitt lymphomas express GLI1. Exposure to Sonic or Indian Hedgehog or cyclopamine (SMO inhibitor) does not modulate GLI1 expression, cell proliferation, or apoptosis in most Burkitt lymphoma cell lines. Sequence analysis of PTCH1, SMO, and SuFu failed to show mutations that might explain the lack of Hedgehog responsiveness, and we did not detect primary cilia, which may contribute to it. We show that c-MYC interacts with the 5'-regulatory region of GLI1, using chromatin immunoprecipitation (ChIP) assay, and E-box-dependent transcriptional activation of GLI1 by c-MYC in NIH3T3 and HeLa cells. The c-MYC small-molecule inhibitor 10058-F4 downregulates GLI1 mRNA and protein and reduces the viability of Burkitt lymphoma cells. Inhibition of GLI1 by GANT61 increases apoptosis and reduces viability of some Burkitt lymphoma cells. Collectively, our data provide evidence that c-MYC directly regulates GLI1 and support an antiapoptotic role for GLI1 in Burkitt lymphoma. Burkitt lymphoma cells do not seem to be Hedgehog responsive. These findings suggest a mechanism for resistance to SMO inhibitors and have implications for using SMO inhibitors to treat human cancers.
Practical predicate placement (1994)

Recent work in query optimization has addressed the issue of placing expensive predicates in a query plan. In this paper we explore the predicate placement options considered in the Montage DBMS, presenting a family of algorithms that form successively more complex and effective optimization solutions. Through analysis and performance measurements of Montage SQL queries, we classify queries and highlight the simplest solution that will optimize each class correctly. We demonstrate limitations of previously published algorithms, and discuss the challenges and feasibility of implementing the various algorithms in a commercial-grade system.
Getting Started in Technical Analysis (1999)

BASIC ANALYSIS TOOLS. Charts: Forecasting Tool or Folklore? Types of Charts. Trends. Trading Ranges and Support and Resistance. Chart Patterns. Oscillators. Is Chart Analysis Still Valid? TRADING ISSUES. Midtrend Entry and Pyramiding. Choosing Stop-Loss Points. Setting Objectives and Other Position Exit Criteria. The Most Important Rule in Chart Analysis. Real-World Chart Analysis. TRADING SYSTEMS. Charting and Analysis Software. Technical Trading Systems: Structure and Design. Testing and Optimizing Trading Systems. PRACTICAL TRADING GUIDELINES. The Planned Trading Approach. Eighty-Two Trading Rules and Market Observations. Market Wiz(ar)dom. Appendix. Glossary. Index.
A Radical Double Agent (1992)

(1992). A Radical Double Agent. The Black Scholar: Vol. 22, The Clarence Thomas Confirmation, pp. 24-25.
A Framework for Fingerprint-Based Detection of Repeating Objects in Multimedia Streams (2012)

We present an original framework for the detection of repeating objects in multimedia streams. This framework is designed so that it can work with any fingerprint model. A fingerprint is extracted for each incoming frame of the multimedia stream. The framework then manages this fingerprintso that if one similar frame comes later in the stream, it will be identified as a repetition. The framework has been tested with two distinct fingerprint models on simulated and ’realworld’ data. The results show that the framework performs well with both presented models and that it is suitable for industrial use-cases.
Evaluating PFAS cross contamination issues (2018)

Abstract Avoiding cross contamination from per‐ and polyfluoroalkyl substances (PFAS) that may occur during sampling of environmental media is the key to ensure reliable analytical results during a PFAS sampling program. Due to the ubiquitous nature of PFAS in commonly used sampling materials and personal protective equipment, mitigating the risk of cross contamination is a challenge that requires a conservative approach when planning and executing a PFAS sampling program. This article describes a conservative approach to PFAS sampling and includes a case study that evaluated three insect repellent products to determine their suitability for use during PFAS investigation. The three products were verified to be PFAS‐free for the 17 PFAS included in the analysis and, therefore, these products are suitable for use during PFAS sampling activities without concern for cross contamination.
Determination of gold and silver in dross using EDXRF technique (2014)

Gold and silver in dross were determined by energy‐dispersive X‐ray fluorescence technique. Sample was prepared by pressed pellet method using microcrystalline cellulose powder as binder, and a method of standard additions was used for quantification. L β X‐ray of gold (11.4 keV) and K β X‐ray of silver (24.9 keV) were used for analysis. The measured concentrations of gold and silver were 132 ± 8 and 1181 ± 84 mg kg −1 , respectively. The results were validated by instrumental neutron activation analysis technique. The t ‐test indicated that there was no significant difference between results obtained by the two techniques. Energy‐dispersive X‐ray fluorescence is a simple, precise and accurate technique for the determination of gold and silver in dross. Copyright © 2014 John Wiley & Sons, Ltd.
[Pathogenesis of atopic dermatitis]. (1991)

Atopic dermatitis shows a familial disposition and is characterised clinically by extreme pruritus, typical eczematoid pathology and distribution on the integument, a chronic relapsing course, and a personal or familial history of atopic diseases (allergic bronchial asthma, rhinitis and allergic conjunctivitis, atopic dermatitis), as well as numerous other stigmata and microsymptoms. Although numerous exogenous factors help trigger the disease, more recent findings point to an immunological basis. In recent years, numerous cellular malfunctions of immune cells have been reported, with disturbances in T-lymphocyte predominating. The latest investigations now suggest that the reported changes in the immune response are due to an imbalance in the cytokine network. Thus, it has been observed that disturbances of cytokine production depend upon the severity of the disease, and show an AD-characteristic pattern. The pathogenesis of atopic dermatitis however, is not yet fully understood.
The Laminins: Role in Intestinal Morphogenesis and Differentiation (1998)

Dynamic and reciprocal heterotypic cell interactions are crucial for intestinal morphogenesis and differentiation. This paper emphasizes the role of basement membrane molecules and in particular of laminins as potent mediators in this intercellular cross talk. Changes in the expression or localization of laminin isoforms or of integrins during development and cell migration strengthen the concept that heterogeneity in cell-matrix interactions could mediate distinct cell responses. A combination of genetic or biochemical approaches associated with in vitro models allows us to study the potential role of each laminin isoform in basement membrane assembly, cell migration, or cell differentiation.
Automatic semblance velocity analysis using Convolutional Neural Networks (2019)

Velocity analysis can be a time-consuming task when it is performed manually. Methods have been proposed to automate the process of velocity analysis, which, however, typically requires significant manual effort. We propose using the Convolutional Neural Network (CNN) to estimate stacking velocities directly from the semblance. Our CNN model uses two images as one input data for training. One is the entire semblance (guide image), and the other is a small patch (target image) extracted from the semblance at a specific time step. Labels for each input dataset are the root mean square (RMS) velocities. We generate the training dataset using synthetic data. After training the CNN model with synthetic data, we test the trained model with other synthetic data that was not used in the training step. The result shows that the model can predict a consistent velocity model. One also notices that when the input data is extremely different from the one used for the training, the CNN model will hardly pick the correct velocities. In this case, I propose to adopt transfer learning to update the trained model (base model) with a small portion of the target data. The latter improves the accuracy of the predicted velocity model. The Marmousi dataset and a marine dataset from the Gulf of Mexico are used for validating the proposed automatic velocity analysis algorithm.
Botulinum toxin antibody type A titres after cessation of botulinum toxin therapy (2002)

In some patients, therapy with botulinum toxin type A (BT-A) becomes ineffective due to formation of antibodies (BT-A-AB). The time course of BT-A-AB titres after cessation of BT-A therapy was quantitatively studied to determine whether and when they might drop. Thirteen patients (eight women, five men) with various dystonic syndromes and complete secondary therapy failure (CSTF) were included in this study (age at initiation of BT-A therapy, 48.2 +/- 11.3 years; number of injection series, 7.7 +/- 2.9; treatment time, 678.8 +/- 385.6 days; mean interinjection interval, 90.4 +/- 35.5 days; mean single dose, 546.7 +/- 336.9 EMU; cumulative dose, 4185.1 +/- 3375.7 EMU [1 EMU = 1 botox MU = 3 dysport MU]). During a monitoring period of at least 750 days after occurrence of CSTF, two or more BT-A-AB tests using the quantitative mouse diaphragm assay were performed. Eight of 13 BT-A-AB titres decreased. The onset of decrease could be detected after between approximately 500 and 1,750 days. After 1,250 to 2,250 days they had dropped below a level of 0.002 U/ml, where CSTF is unlikely. Five of 13 BT-A-AB titres did not decrease. For three of these five, the monitoring period was less than 1,500 days; a chance to drop remained. The other two were monitored for up to 2,400 days. Patients with decreasing and nondecreasing BT-A-AB titres did not exhibit statistically significant differences in either clinical characteristics or treatment parameters. When BT-A therapy was stopped the majority of BT-A-AB titres eventually decreased, allowing reinitiation of BT-A therapy. Application of new BT-A preparations with low antigenic potency might then become an interesting treatment option.
Efficiency Reduction in Stirling Engines Resulting from Sinusoidal Motion (2018)

Stirling engines have a high potential to produce renewable energy due to their ability to use a wide range of sustainable heat sources, such as concentrated solar thermal power and biomass, and also due to their high theoretical efficiencies. They have not yet achieved widespread use and commercial Stirling engines have had reduced efficiencies compared to their ideal values. In this work we show that a substantial amount of the reduction in efficiency is due to the operation of Stirling engines using sinusoidal motion and quantify this reduction. A discrete model was developed to perform an isothermal analysis of a 100cc alpha-type Stirling engine with a 90 ∘ phase angle offset, to demonstrate the impact of sinusoidal motion on the net work and thermal efficiency in comparison to the ideal cycle. For the specific engine analyzed, the maximum thermal efficiency of the sinusoidal cycle was found to have a limit of 34.4%, which is a reduction of 27.1% from Carnot efficiency. The net work of the sinusoidal cycle was found to be 65.9% of the net work from the ideal cycle. The model was adapted to analyze beta and gamma-type Stirling configurations, and the analysis revealed similar reductions due to sinusoidal motion.
Development of piezoelectric and electrodynamic flexural transducers for air-coupled ultrasonics (2016)

Phased array ultrasound transducers could offer significant benefits over single element transducers in flow metering technology. By steering the ultrasonic beam transmitted through the flow, a single pair of phased array transducers have the potential to replace several pairs of traditional single element transducers. A first step in researching the potential for phased array transducers in flow meters is to investigate a suitable array element.\n\nFlexural ultrasound transducers use the bending modes in a thin plate to generate ultrasound waves in low impedance media, such as liquids and gases. The behaviour of piezoelectric flexural transducers was studied using theoretical modelling, finite element (FE) modelling and experimental techniques. Some focus was put on characterising the passive layer of the transducer, which was shown to be largely responsible for the flexural behaviour. That is, the dimensions of the passive layer largely determined the resonance frequencies of the flexural vibration modes of the transducer. Also, the viability of flexural transducers for flow applications was assessed.\n\nA new method of constructing air-coupled ultrasound phased array transducers was suggested. A 3 x 3 array was constructed and tested. The individual elements of the array behaved as single element flexural transducers, but the system as a whole could be improved to allow for better beam shaping.\n\nA novel electrodynamic flexural transducer (EDFT) for air-coupled ultrasonic transduction without use of piezoelectric materials was proposed, developed and experimentally tested. The transducer combines the contactless coupling method used by electromagnetic acoustic transducers (EMATs) with the flexural vibration modes of a thin plate to transmit and receive ultrasound waves in air. The output pressure of the transducers was high, with SPLs over 100 dB, but the sensitivity was low compared to piezoelectric transducers.
Long-Stroke Rod Pumping Systems LSPS in High-Volume Unconventional Applications (2018)

Abstract With drilling/completion developments and changes in well production rates creating greater challenges for reciprocating pump systems, there is currently a much larger "need" for the benefits provided by long-stroke pumping systems (LSPS). This need includes the ability to economically produce the required (often higher) volume of oil and gas while providing acceptable life-cycle costs/runtimes, which are frequently impacted by deviation, gas, debris, and increased loads. Additionally, lower oil prices in the past 3-4 years have also emphasized the importance of the LSPS's ability to minimize operating costs and maximize mean time between failures (MTBF). This paper will demonstrate how an effectively designed and operated LSPS can improve rod pump efficiency, and achieve higher production rates while reducing failures and operating costs within high production/deviated applications.
Three-Dimensional Image Reconstruction for jPET-D4 Using Suitable Histogramming Method to DOI Detector (2005)

The next generation PET scanner named JPET-D4 has been developed at the National Institute of Radiological Sciences (NIRS) in Japan. The JPET-D4 has 4 layers DOI detectors and its data size becomes huge to handling. Then at first stage, we plan to apply the reconstruction techniques after the histogramming of list-mode data because it is easy to implement and effective to decrease computational cost The conventional histogramming technique is inapplicable to 4 layers DOI detectors, so we proposed the new histogramming method which is suitable for the multi-layer DOI detector. In this method, DOI-PET list-mode data is transformed into sinogram with an accurate system model of the crystal block. In this paper, we implemented this method with a full three dimensional system model. And we also applied the method to experimental data with prototype system for the JPET-D4 scanner. Experimental results show that the proposed method keeping the advantage of DOI information, and the image quality of the JPET-D4 is superior to a conventional NonDOI PET scanner.
Molybdenum‐Catalyzed Deoxydehydration of Vicinal Diols (2014)

The commercially available (NH4 )6 Mo7 O24 and other molybdenum compounds are shown to be viable substitutes for the typically employed rhenium compounds in the catalytic deoxydehydration of aliphatic diols into the corresponding alkenes. The transformation, which represents a model system for the various hydroxyl groups found in biomass-derived carbohydrates, can be conducted in an inert solvent (dodecane), under solvent-free conditions, and in a solvent capable of dissolving biomass-derived polyols (1,5-pentanediol). The reaction is driven by the simultaneous oxidative deformylation of the diol resulting in an overall disproportionation of the substrate.
Optical packet switching and buffering by using all-optical signal processing methods (2003)

We present a 1 × 2 all-optical packet switch. All the processing of the header information is carried out in the optical domain. The optical headers are recognized by employing the two-pulse correlation principle in a semiconductor laser amplifier in loop optical mirror (SLALOM) configuration. The processed header information is stored in an optical flip-flop memory that is based on a symmetric configuration of two coupled lasers. The optical flip-flop memory drives a wavelength routing switch that is based on cross-gain modulation in a semiconductor optical amplifier. We also present an alternative optical packet routing concept that can be used for all-optical buffering of data packets. In this case, an optical threshold function that is based on a asymmetric configuration of two coupled lasers is used to drive a wavelength routing switch. Experimental results are presented for both the 1 × 2 optical packet switch and the optical buffer switch.
Object-oriented repository services (2002)

SoftAnal and SoftRepo are tools developed to provide repository services to a Viennese software house-Software Data Service-that has developed a series of financial service software systems now in the evolution phase. Repository services include automated software measurement, automated code inspection, automated post-documentation, automated generation of test cases, impact analysis, evolution project estimation and software structure visualization.
Receptors Involved in the Oxidized 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated Synthesis of Interleukin-8 (2003)

We demonstrated previously that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC) and, specifically, the component lipid 1-palmitoyl-2-(5,6-epoxyisoprostane E2)-sn-glycero-3-phosphorylcholine increase interleukin-8 (IL-8) synthesis in aortic endothelial cells. The goal of the current studies was to characterize the receptor complex mediating the increased transcription of IL-8. We demonstrate that scavenger receptor class A, types I and II, lectin-like ox-LDL receptor-1, macrophage receptor with collagenous structure, and CD36 are not responsible for the increase in IL-8. Using dominant-negative constructs and antisense oligonucleotides, we demonstrate a role for Toll-like receptor 4 (TLR4) as the ox-PAPC receptor mediating IL-8 transcription. We demonstrate that a glycosylphosphatidylinositol (GPI)-anchored protein is also necessary because phosphatidylinositol-specific phospholipase C pretreatment inhibited the effect of ox-PAPC. CD14, a GPI-anchored protein that associates with TLR4 in mediating lipopolysaccharide action, did not appear to mediate ox-PAPC action because ox-PAPC-induced IL-8 transcription was not blocked by anti-CD14 neutralizing antibodies nor was it augmented by the addition of soluble CD14 or overexpression of membrane CD14. Instead, anti-TLR4 antibodies immunoprecipitated a 37-kDa protein that also bound ox-PAPC. A protein of this same size was found in aerolysin overlays used to detect GPI-anchored proteins. Therefore, these studies suggest that ox-PAPC may initially bind to a 37-kDa GPI-anchored protein, which interacts with TLR4 to induce IL-8 transcription.
Integrated bulk-micromachined gyroscope using deep trench isolation technology (2004)

A novel single-chip bulk-micromachined integrated gyroscope was designed and fabricated in a compatible CMOS process. Using high aspect ratio (30:1) trench etching technology, deep trench electrical isolation materials refilling, and backside etching technologies, bulk MEMS structures and circuits (a part of preamplifier and temperature sensor) were integrated into a single-crystal silicon wafer. A Z-axis integrated gyroscope has been fabricated using this technology, which is compatible with the standard CMOS process. The integrated gyroscope device is 3.5 mm by 3.5 mm in size and has a 100 /spl mu/m thick single-crystal silicon proof mass. At atmosphere pressure, the packaged gyroscope exhibited a low noise floor (0.008/spl deg//sec//spl radic/Hz), large scale factor (3.7 mV//spl deg//sec), small nonlinearity (0.08%), and good excursion stability (40/spl deg//hr//spl radic/Hz).
Acetylenic-terminated fluorinated polyimide, properties and applications (1987)

A new line of acetylene-terminated, oligomeric polyimides has been introduced for aerospace and electronic applications. The oligomers are derived from the monomers 4,4'-hexafluoroisopropylidinebis(phthalic anhydride), 1,3'-bis(3-aminophenoxy)benzene, and 3-ethynylaniline. They are fully imidized and cure by reactions of the terminal ethynyl groups. These products have unique properties when compared with similar systems containing nonfluorinated dianhydrides. Studies have shown improved solubility in a variety of solvents and stable solutions at high concentrations. The glass transition temperature is in the 300-350 C range. Decomposition by thermal gravimetric analysis (TCA), occurs at about 550 C. The weight loss by isothermal TGA is less than 1.0 percent per hour at 400 C in air. The dielectric constants are less than 3.0 over a wide range of frequencies. 9 references.
A hydrophilic covalent organic framework for photocatalytic oxidation of benzylamine in water (2019)

The highly hydrophilic COF material (TFPT-BMTH) was constructed by pore surface functionalizing strategy, and exhibited excellent porosity, high crystallinity, and good thermal and chemical stability. The resulting COF exhibits significant catalytic activity and recyclability together with environmental benignity in photocatalytic oxidation of benzylamine in water under ambient conditions.
Fractal based image compression with affine transformations (2002)

As the needs for information transfer and storage increase, data coding and compression become increasingly important in applications such as digital HDTV, telefax, ISDN and image data bases. The authors have developed a fractal image compression method and tested it with binary (black and white) images. The decoded results are similar to the original images. The compression ratios are found to be extremely high.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>