gebhart/patrepeval huggingface dataset:
Differential biologic effects resulting from bimodal binding of recombinant human tumor necrosis factor to myeloid leukemia cells (1989)

Human recombinant tumor necrosis factor (rTNF) bound to ML-1 and HL-60 human myeloid leukemia cells in a bimodal manner. Saturable high- affinity binding was maximal at approximately 3 nmol/L rTNF, whereas saturable low-affinity binding reached its maximum at approximately 30 nmol/L. As analyzed by computer program, the observed data fit a two- receptor site model, with p less than .05. High-affinity binding concentrations of rTNF caused the differentiation of both cell lines, whereas low-affinity binding concentrations abolished this effect in a concentration-dependent manner. Thus, the type of biologic response elicited with rTNF in these cells is a function of the concentration at which the factor is applied. If generally applicable, this bimodal effect may require consideration when rTNF is to be used therapeutically.
Preparing hPSC-derived neurons for single-cell RNA sequencing v1 (2020)

This protocol is about Preparing hPSC-derived neurons for single-cell RNA sequencing.
Surfactant‐Free Scalable Synthesis of Bi<sub>2</sub>Te<sub>3</sub> and Bi<sub>2</sub>Se<sub>3</sub> Nanoflakes and Enhanced Thermoelectric Properties of Their Nanocomposites (2012)

Surfactant-free nanoflakes of n-type Bi2 Te3 and Bi2 Se3 are synthesized in high yields. Their suspensions are mixed to create nanocomposites with heterostructured nanograins. A maximum ZT (0.7 at 400 K) is achieved with a broad content of 10-15% Bi2 Se3 in the nanocomposites.
Comparative metagenomics of three Dehalococcoides-containing enrichment cultures: the role of the non-dechlorinating community (2012)

Comparative metagenomics of the three Dehalococcoides-containing consortia identified that similarities across the three consortia are more apparent at the functional level than at the taxonomic level, indicating the non-dechlorinating organisms' identities can vary provided they fill the same niche within a consortium. Functional redundancy was identified in each metabolic pathway of interest, with key processes encoded by multiple taxonomic groups. This redundancy likely contributes to the robust growth and dechlorination rates in dechlorinating enrichment cultures.
The Cytochrome P450 Superfamily: Biochemistry, Evolution and Drug Metabolism in Humans (2002)

Cytochrome p450s comprise a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, cytochrome p450s are best know for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism. Recent advances in our understanding of cytochrome p450-mediated drug metabolism have been accelerated as a result of an increasing emphasis on functional genomic approaches to p450 research. While human cytochrome p450 databases have swelled with a flood of new human sequence variants, however, the functional characterization of the corresponding gene products has not kept pace. In response researchers have begun to apply the tools of proteomics as well as homology-based and ab initio modeling to salient questions of cytochrome p450 structure/function. This review examines the latest advances in our understanding of human cytochrome p450s.
Long Term Follow Up: Phase I Trial of “bi-shRNA furin/GMCSF DNA/Autologous Tumor Cell” Immunotherapy (FANG™) in Advanced Cancer (2013)

Study Background: Previously, we demonstrated safety and correlated induced immune response with survival in a Phase I study of FANG immunotherapy in advanced cancer patients. We now report long term follow-up (FU) of Phase I treated patients including assessment of relationships of dose, γIFN-ELISPOT response, and patient demographics to safety and survival. Methods: Safety, γIFN-ELISPOT response, and survival have been followed through 3+ years in advanced cancer patients who received ≥ 2-12 intradermal monthly injections of 1×107 or 2.5×107 cells/injection. Clinical and serological assessments were performed monthly, radiographic evaluations bimonthly, and γ-IFN-ELISPOT at baseline, and start of Cycle 2, 4, 6, 9, 12 then sequentially at FU. Results: Previously, we reported results on 45 patients with successful FANG construction followed for 1 year (28 treated (designated FANG); 17 not treated based on availability of other alternative treatments or failed manufacturing (designated No FANG)). We now report FU results through year 3 on those patients and an additional 29 patients (7 FANG, 22 No FANG) subsequently entered into Phase I study (total N=35 FANG; total N=39 No FANG). The median survival of the current expanded Phase I trial population is 562 days vs. 122 days (p=0.00001). This is similar to the originally published data from two years earlier. The γ-IFN-ELISPOT reaction was positive in 14 of the current FANG treated patients and negative in 12 FANG treated patients at Month 3 or less post first injection. Survival correlated with γ-IFN-ELISPOT reaction; median 836 days vs. 440 days with positive and negative ELISPOT respectively, (p=0.04). No long term adverse toxicity has been seen and there was no significant correlation of immune response or survival with either dose or demographics. Conclusions: Treatment with FANG vaccine continues to show long term safety and evidence of benefit in patients with many types of advanced cancer thereby justifying further efficacy testing.
xiao xue yu wen jiao xue zhong shen tou de yu de fang fa (2019)

小学生的心灵就像一张白纸,老师的德育教育将为他们勾勒出成长的底色。小学语文蕴含着丰富的人文内涵,在教学中教师结合学科特点和教材的编辑顺序,在每一个环节中渗透德育,可以润物无声,滋养学生美好的心灵,提升德育的有效性。在此,结合自己的教学体会,对在小学语文教学中渗透德育作如下几方面探究。
ECO-friendly distributed routing protocol for reducing network energy consumption (2010)

The growth of Internet traffic has led to an increase in energy consumption by network equipment such as routers and switches. Consequently, energy consumption is becoming a key environmental, social, political and cost issue. Focusing on energy consumption by Internet Service Provider networks, the energy bottleneck is routers. Thus, it is imperative for us to reduce the energy consumption of routers. In this paper, we propose a new ECO-friendly distributed routing protocol (ECO-RP) based on OSPF. In our proposal, an ECO-RP entity periodically checks the amount of traffic forwarded by the ECO-RP entity. Moreover, an ECO-RP entity floods information on the amount of traffic to other entities such as the OSPF Link State Advertisement. This allows each ECO-RP entity to obtain information on traffic in the network, and to dynamically change OSPF link weights based on the information. For example, when the amount of overall network traffic is small, the entity changes link weights so that the traffic can be routed only through a subset of routers, and unneeded routers can shift into sleep mode. Several simulation studies, which assume two ECO-RP enabled networks, are conducted. The result shows that the proposed protocol is able to reduce energy consumption by about 18.5% at maximum without network congestion.
Generation of three-dimensional content from stereo-panoramic view (2013)

It states that three-dimensional content can be generated from two slightly different panoramic view of a scene. The strength of this thought lies in both the intrinsic movement parallax and single effective viewpoint that is associated with the panoramic view of a scene. These factors when effectively put together have the potential to provide pure perspective image. Three-dimensional effect in a single panoramic image is realized by superimposing a pair of panoramic view images. A special fascination of the resultant image is that depending on how the initial panoramic views are generated, the natural scenery and three-dimensional effect in the composed anaglyph panorama differs. A pair of anaglyph glasses would be used by a group of people to view the depth effect in the stereoscopic panorama.
On/Off TLR Signaling Decides Proinflammatory or Tolerogenic Dendritic Cell Maturation upon CD1d-Mediated Interaction with Invariant NKT Cells (2010)

Invariant NKT (iNKT) cells play an effector/adjuvant function during antimicrobial and antitumoral immunity and a regulatory role to induce immune tolerance and prevent autoimmunity. iNKT cells that differentially modulate adaptive immunity do not bear a unique phenotype and/or specific cytokine secretion profile, thus opening questions on how a single T cell subset can exert opposite immunological tasks. In this study, we show that iNKT cells perform their dual roles through a single mechanism of action relying on the cognate interaction with myeloid dendritic cells (DCs) and leading to opposite effects depending on the presence of other maturation stimuli simultaneously acting on DCs. The contact of murine purified iNKT cells with immature autologous DCs directly triggers the tolerogenic maturation of DCs, rendering them able to induce regulatory T cell differentiation and prevent autoimmune diabetes in vivo. Conversely, the interaction of the same purified iNKT cells with DCs, in the presence of simultaneous TLR4 stimulation, significantly enhances proinflammatory DC maturation and IL-12 secretion. The different iNKT cell effects are mediated through distinct mechanisms and activation of different molecular pathways within the DC: CD1d signaling and activation of the ERK1/2 pathway for the tolerogenic action, and CD40-CD40L interaction and NF-κB activation for the adjuvant effect. Our data suggest that the DC decision to undergo proinflammatory or tolerogenic maturation results from the integration of different signals received at the time of iNKT cell contact and could have important therapeutic implications for exploiting iNKT cell adjuvant/regulatory properties in autoimmune diseases, infections, and cancer.
Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases. (1994)

As an initial step toward understanding its role in steroidogenesis, we studied the developmental profile of steroidogenic factor-1 (SF-1), a nuclear receptor that regulates the steroid hydroxylases. SF-1 transcripts first appear on embryonic day 9 (E9) in the urogenital ridge, the probable source of steroidogenic cells of both adrenals and gonads. By E11, after the adrenals and gonads are clearly separate, SF-1 transcripts are detected throughout the adrenal primordium. Thereafter, adrenal expression of SF-1 localizes to the cortex. Consistent with its proposed role in regulating cholesterol side-chain cleavage enzyme (SCC), SF-1 is expressed before SCC. During the sexually undifferentiated stage of gonadal development (E9-E12), all embryos express SF-1 in the genital ridge. As testicular cords form in males, SF-1 transcripts are diffusely expressed throughout the testis, whereas SCC mRNA is limited to the interstitium. These differences between SF-1 and SCC reflect SF-1 expression by Sertoli cells, as shown by Northern blotting and in situ hybridization. In contrast to its persistent expression in the embryonic testis, SF-1 transcripts disappear from the ovary between E13.5-E16.5, reappearing only during late gestation (E18.5). Thus, expression of SF-1 in the embryonic gonad is sexually dimorphic. Coupled with the demonstration of SF-1 mRNA in Sertoli cells, these data suggest that SF-1 plays a role in gonadal development distinct from regulating the steroidogenic enzymes. Additionally, SF-1 is expressed in the embryonic forebrain, implying a role in neural development.
Laboratory Investigation of Selective Catalytic Reduction Catalysts:  Deactivation by Potassium Compounds and Catalyst Regeneration (2004)

The deactivation and regeneration of selective catalytic reduction (SCR) catalysts poisoned by potassium by a wet-impregnation method was investigated experimentally. Potassium in the form of both chloride and sulfate is a strong poison for the catalyst. The results indicate that potassium titrates the active sites for NH3 adsorption. Simply increasing the operating temperature or the vanadium content in the catalyst cannot compensate the loss of catalyst activity: Increasing the temperature hardly increases the conversion of NO for the strongly poisoned catalysts, and catalysts with high vanadium content become active for oxidizing NH3 to NO, causing a net NO formation. Deactivated catalysts can be regenerated by different methods. Sulfation by gaseous SO2 is efficient provided the poison is first removed by washing. When regenerating by 0.5 M H2SO4, the catalyst regains a higher activity than that of the fresh catalyst at temperatures higher than 300 °C. Heat treatment of the catalyst at 400 °C for 2 h after poisoning to simulate actual operation has no influence on the regeneration by 0.5 M H2SO4. Deactivated catalysts without the heat treatment step regain higher activities than that of the fresh catalyst at all temperatures when regenerated by 1 M NH4Cl. However, the heat treatment step has a negative effect on the regeneration by NH4Cl.
Comparisons of interpolation methods in the presence of aliased events (2003)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2003Comparisons of interpolation methods in the presence of aliased eventsAuthors: Ray AbmaNurul KabirRay AbmaBP‐EPTG and Nurul KabirBP‐EPTGhttps://doi.org/10.1190/1.1817693 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1817693FiguresReferencesRelatedDetailsCited ByAccurate data reconstruction through simultaneous application of statistical and physics-based constraints to multiple geophysical data setsAnatoly Baumstein and Ramesh Neelamani22 December 2010 | GEOPHYSICS, Vol. 75, No. 620. Signal Processing21 March 2010Fourier reconstruction of nonuniformly sampled, aliased seismic dataGEOPHYSICS, Vol. 72, No. 13D surface-related multiple elimination: Data reconstruction and application to field dataGEOPHYSICS, Vol. 71, No. 33D inverse shot record DMO: A tool for shot‐domain data regularizationAnatoly Baumstein3 January 2005 SEG Technical Program Expanded Abstracts 2003ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2003 Pages: 2452 publication data© 2003 Copyright © 2003 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 03 Jan 2005 CITATION INFORMATION Ray Abma and Nurul Kabir, (2003), "Comparisons of interpolation methods in the presence of aliased events," SEG Technical Program Expanded Abstracts : 1909-1912. https://doi.org/10.1190/1.1817693 Plain-Language Summary PDF DownloadLoading ...
Material issues for nanoporous ultra low-k dielectrics (2004)

Using the molecularly designed porogen (pore generating agent) approach, novel nanoporous low-k materials with improved mechanical properties have been achieved based on poly(methylsilsesquioxane), PMSSQ, structure. Two different methods, microphase separation system and grafted porogen system, were adopted to realize nonporous ultra low-k dielectrics with superior mechanical properties. We found that the behavior of dielectric constant as well as thin film modulus depends on the molecular structure of a porogen. Within the decomposition temperature windows of grafted porogens, a low-k material with k < 2.2 and Young's modulus > 6 Gpa was achieved. These results indicate that it is possible to design and fabricate nanoporous thin films with balanced low dielectric constant and robust mechanical properties, which are highly desired for microelectronic industry.
12 Developing Partnership Approaches to Tourism in Central and Eastern Europe (2000)

In m any of the form er socialist countries of Central and Eastern Europe (CEE), the concept of developing wider involvement w ithin decision making-processes remains inherently problem atic.Prior to 1989, public participation was a limited and often ignored aspect of policy making.However, m ore recently throughout the region, tourist agencies, new regional organisations, a range of non-governmental organisations, and community groups have em erged in response to potential growth in new tourism industries, thus expanding the number of stakeholders involved.This paper investigates collaboration and partnership working in two rural regions of Bulgaria and Romania, countries unable to m atch the perform ance of their CEE counterparts w here tourism development is concerned.It provides a reflective analysis of achievem ents within a fram ew ork of prerequisites to successful partnership working.A lthough both examples illustrate the emergence of new development practices, the paper questions their sustainability.The analysis identifies a num ber of elements, comm on to both cases, that illustrate the need to focus the evaluation of partnership w orking on long-term processes rather than short-term , m ore m easurable outcom es.
A Seamless Network Database Migration Tool for Insititutions in Zambia (2018)

The objective of the research was to efficiently manage migration process between different Database Management Systems (DBMS) by automating the database migration process. The automation of the database migration process involved database cloning between different platforms, exchange of data between data center and different clients running non-identical DBMS and backing up the database in flexible format, such as eXtensible Markup Language (XML). This approach involved development of a “Database Migration Tool”. The tool was developed on a windows platform using Java Eclipse™ with four non-identical dummy Relational Databases (Microsoft Access, MySQL, SQL Server and Oracle). The tool was run in a controlled environment over the network and databases were successfully migrated from source to targeted destination option specified. The developed tool is more efficient, timely, as well as highly cost effective.
Origin of the Isomer Stability of Polymethylated DOTA Chelates Complexed with Ln<sup>3+</sup> Ions (2021)

DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-based chelates that give only a single isomer in solution when complexed with lanthanide (Ln<sup>3+</sup>) ions is of value for studying protein dynamics and interactions via NMR. Herein, we have investigated the geometries, energetics, and electrostatic potentials of Lu complexed with DOTA (<b>1</b>), ring methylated M4DOTA (<b>2</b>), and arm methylated <i>R</i>-DOTMA (<b>3</b>) and <i>S</i>-DOTMA (<b>4</b>), as well as, both ring and arm methylated 4<i>S</i>-4<i>S</i>-M4DOTMA (<b>5)</b> and 4<i>S</i>-4<i>R</i>-M4DOTMA (<b>6</b>) at the level of M06-L/6-31+G(d)-SDD, to elucidate the origin of the isomer stability. These analyses indicate that the electrostatic repulsion between the arm methyl and the neighboring carboxylate significantly destabilizes the square antiprism (SAP) isomer of Lu-<b>5</b> and the twisted square antiprism (TSAP) isomer of Lu-<b>6</b>, while the steric repulsion between the ring and arm methyl groups attenuates the stability of both TSAP of Lu-<b>5</b> and SAP of Lu-<b>6</b>. To rationalize the variable temperature proton NMR spectra, the energy barriers for the inter-conversion in Lu-<b>5</b> and Lu-<b>6</b> via arm rotation were also calculated. The modulation of the stability and rigidity of Ln complexes via a modification of DOTA is also discussed. Our investigation will aid to design better chelates for the Ln<sup>3+</sup> ions for its use in molecular medicine.
A Hybrid Sound Model for 3D Audio Games with Real Walking (2016)

Spatialized audio is the only output that players receive in audio games. In order to provide a realistic view of the environment, it has to be of superior quality in terms of immersion and realism. Complex sound models can be used to generate realistic sound effects, including reflections and reverb. An implementation of a hybrid sound model based on the ODEON approach is introduced and adapted for real-time sound calculations. This model is evaluated and compared to a baseline model usually used in audio games in a user study in a virtual reality environment. The results show that the implemented hybrid model allows players to adjust to the game faster and provides them more support in avoiding virtual obstacles in simple room geometries than the baseline model.
Growth Of Indian Higher Education: An Analysis (2016)

In this research paper an attempt has been made to highlight increased institutional capacity in terms of diverse levels of Universities and colleges in the country. India has one of the largest higher Education systems which saw a remarkable increase since independence. In terms of enrolment, India has the third largest higher education system in the world after China and USA.  It is expected that India will top the USA in next five years and China in next fifteen years to be the largest system of higher education in the world.
Self Organized Physical Cell ID Assignment in Multi-Operator Heterogeneous Networks (2015)

We discuss Physical Cell ID (PCI) assignment for densely deployed heterogeneous networks (HetNets), in a multioperator spectrum sharing scenario. The aim is to achieve PCI assignment that is conflict-free and confusion-free, jointly for multiple operators, in a self-organized way. A graph coloring formulation is used to model the problem where the PCIs represent the colors used to color the interference graph. The graph is created using the interference couplings determined by handover measurements of the user equipments served by the HetNet. The PCI assignment algorithms considered are based on local search methods used in conjunction with the focused search principle, which allows PCI reconfigurations only to the cells with unsatisfied constraints related to conflicts and confusions. The algorithms considered are fully distributed and do not involve message-passing between the operators. Each cell decides its PCI by observing the PCIs of its neighbors which include its own network cells as well as the cells that belong to the other operators but share the same spectrum. Simulations results show that the proposed algorithms have good convergence properties and are effective for self-organized PCI assignment in dense multioperator networks with shared spectrum.