gebhart/patrepeval huggingface dataset:
Detection of microtexture regions in titanium turbine engine disks using process compensated resonance testing: A modeling study (2019)

Titanium alloys used by the aerospace industry, like Ti-64 or Ti-6242, with Microtexture Regions (MTR’s) have been shown to exhibit significantly reduced dwell fatigue lifetimes. Over the last several decades, these titanium alloys have been used for critical components such as turbine engine disks, which are then susceptible to failure well below their expected service life. Current Nondestructive Inspection (NDE) methods are time consuming and can miss MTR’s. Process Compensated Resonance Testing (PCRT) is a fast and accurate full-body NDE method that has been proposed for the detection of MTR’s in titanium turbine engine disks. PCRT excites a part’s resonance frequencies and correlates the resonance spectrum to the part’s material and/or damage state. Turbine engine disks with MTR’s will have different resonance spectra than fully isotropic disks. Both the MTR’s geometric parameters (i.e. size, location, and orientation) and the microstructural parameters (i.e. degree of crystal alignment and orientation) will influence the magnitude and pattern of changes in the resonance spectrum. Using a Monte-Carlo approach, this work developed Finite Element Method (FEM) model population of disks with and without MTR’s. These populations were analyzed to predict the effects of MTR parameter variation on resonance spectra and evaluate PCRT sensitivity to MTR’s in the presence of normal geometric and material property variation. The feasibility of detecting MTR’s in titanium turbine engine disks using PCRT methods is presented and discussed.
Naringin and Neohesperidin Levels during Development of Leaves, Flower Buds, and Fruits of Citrus aurantium (1992)

The distribution of the flavanones naringin and neohesperidin has been analyzed during the development of the leaves, flower buds, and fruits of Citrus aurantium. These flavonoids are at maximum concentration in the organs studied during the logarithmic phase of growth, gradually decreasing until the organs reach maximum development. However, this decrease in the naringin and neohesperidin concentration in leaves, flower buds, and fruits is due to a dilution of the flavonoids caused by cell growth, because total content per organ continues to increase. The levels of neohesperidin are always greater than those of naringin, although the ratio between the relative concentrations is different in the three organs studied. Leaves have the highest ratios, varying between 8.83 and 5.18, followed by flowers (3.15-1.85), and fruits (2.23-1.02). These observations suggest different relationships between the respective enzymic activities in their biosynthetic pathway.
Creating automatically aligned consensus realities for AR videoconferencing (2014)

This paper presents an AR videoconferencing approach merging two remote rooms into a shared workspace. Such bilateral AR telepresence inherently suffers from breaks in immersion stemming from the different physical layouts of participating spaces. As a remedy, we develop an automatic alignment scheme which ensures that participants share a maximum of common features in their physical surroundings. The system optimizes alignment with regard to initial user position, free shared floor space, camera positioning and other factors. Thus we can reduce discrepancies between different room and furniture layouts without actually modifying the rooms themselves. A description and discussion of our alignment scheme is given along with an exemplary implementation on real-world datasets.
I have never made a career decision in my life : talking to... Dick Stacey (2009)

Stacey explains that he is actually a mechanical engineer by training but that he had never worked in that field. He was born in Durban in 1943 but his family lived in King Williams Town. ''That is where I started my schooling. But my family relocated to Zimbabwe, then known as Rhodesia, where I completed what is equivalent to A levels. I knew that I wanted to become an engineer, so in 1962 I enrolled for a course in mechanical engineering at the University of Natal.' Stacey may have been pre-disposed to become an engineer. Two great grandfathers were mine managers in gold mines in Bendigo and Coolgardie, Australia. His grandfather eventually emigrated to South Africa.
sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Nucleotide sequence of the EPT1 gene and comparison of the CPT1 and EPT1 gene products. (1991)

The complete nucleotide sequence of the Saccharomyces cerevisiae EPT1 gene, a structural gene encoding an sn-1,2-diacylglycerol ethanolamine- and cholinephosphotransferase (Hjelmstad, R. H., and Bell, R. M. (1988) J. Biol. Chem. 263, 19748-19757), was determined. The 2123-nucleotide extent of DNA sequenced contained an open reading frame encoding 391 amino acids interrupted by an intron near its 5' end. Northern hybridization analysis detected a single 1.4-kilobase transcript. The inferred 44,525-dalton EPT1 gene product exhibited 54% amino acid sequence homology to the cholinephosphotransferase product of the yeast CPT1 gene. Predictive structural analysis of the EPT1 gene product revealed close structural similarity to the CPT1 gene product with respect to membrane topography, features of secondary structure, and transmembrane asymmetry. Regional protein homologies were identified between the EPT1 gene product and several enzymes as well as the nicotinic acetylcholine receptor. Comparative analysis of this set of protein homologies and the related set of protein homologies to the CPT1 gene product permitted identification of a presumptive active site region which contains highly conserved and divergent subregions and a common mononucleotide binding site.
Enantioselective Sulfide Oxidation with H2O2: A Solid Phase and Array Approach for the Optimisation of Chiral Schiff Base-Vanadium Catalysts (2002)

Two libraries of chiral Schiff base ligands were synthesised and screened in the vanadium-catalysed oxidation of alkyl aryl sulfides with hydrogen peroxide as terminal oxidant. The vanadium-chiral Schiff base complex 10, readily prepared from 3,5-diiodo-salicylaldehyde and (S)-tert-leucinol, was found to be highly enantioselective. Optically active sulfoxides could thus be obtained in good yields with up to 97% ee.
Consonant and vowel confusions in speech-weighted noise (2006)

This paper presents the results of a closed-set recognition task for 64 consonant-vowel sounds (16 C X 4 V, spoken by 18 talkers) in speech-weighted noise (-22,-20,-16,-10,-2 [dB]) and in quiet. The confusion matrices were generated using responses of a homogeneous set of ten listeners and the confusions were analyzed using a graphical method. In speech-weighted noise the consonants separate into three sets: a low-scoring set C1 (/f/, /theta/, /v/, /d/, /b/, /m/), a high-scoring set C2 (/t/, /s/, /z/, /S/, /Z/) and set C3 (/n/, /p/, /g/, /k/, /d/) with intermediate scores. The perceptual consonant groups are C1: {/f/-/theta/, /b/-/v/-/d/, /theta/-/d/}, C2: {/s/-/z/, /S/-/Z/}, and C3: /m/-/n/, while the perceptual vowel groups are /a/-/ae/ and /epsilon/-/iota/. The exponential articulation index (AI) model for consonant score works for 12 of the 16 consonants, using a refined expression of the AI. Finally, a comparison with past work shows that white noise masks the consonants more uniformly than speech-weighted noise, and shows that the AI, because it can account for the differences in noise spectra, is a better measure than the wideband signal-to-noise ratio for modeling and comparing the scores with different noise maskers.
Use of the <i>Rhodopseudomonas palustris</i> genome sequence to identify a single amino acid that contributes to the activity of a coenzyme A ligase with chlorinated substrates (2005)

Rhodopseudomonas palustris strain RCB100 degrades 3-chlorobenzoate (3-CBA) anaerobically. We purified from this strain a coenzyme A ligase that is active with 3-CBA and determined its N-terminal amino acid sequence to be identical to that of a cyclohexanecarboxylate-CoA ligase encoded by aliA from the R. palustris strain (CGA009) that has been sequenced. Strain CGA009 differs from strain RCB100 in that it does not use 3-CBA as a sole carbon source. The aliA gene from the 3-CBA degrading strain differed by a single nucleotide from the aliA gene from strain CGA009, causing the substitution of a serine for a threonine at position 208. Both AliA enzymes, purified as His-tagged fusion proteins, had comparable activities with cyclohexanecarboxylate. However, AliA from the 3-CBA degrading strain was 10-fold more active with 3-CBA (kcat/Km of 4.3 x 10(4) M(-1) s(-1)) than the enzyme from the sequenced strain (kcat/Km 0.32 x 10(4) M(-1) s(-1)). The CGA009 enzyme was not sufficiently active with 3-CBA to complement an RCB100 aliA mutant for growth on this compound. Here, whole genome sequence information enabled us to identify a single nucleotide among 5.4 million nucleotides that contributes to the substrate preference of a coenzyme A ligase.
Rank Pooling for Action Recognition (2016)

We propose a function-based temporal pooling method that captures the latent structure of the video sequence data - e.g., how frame-level features evolve over time in a video. We show how the parameters of a function that has been fit to the video data can serve as a robust new video representation. As a specific example, we learn a pooling function via ranking machines. By learning to rank the frame-level features of a video in chronological order, we obtain a new representation that captures the video-wide temporal dynamics of a video, suitable for action recognition. Other than ranking functions, we explore different parametric models that could also explain the temporal changes in videos. The proposed functional pooling methods, and rank pooling in particular, is easy to interpret and implement, fast to compute and effective in recognizing a wide variety of actions. We evaluate our method on various benchmarks for generic action, fine-grained action and gesture recognition. Results show that rank pooling brings an absolute improvement of 7-10 average pooling baseline. At the same time, rank pooling is compatible with and complementary to several appearance and local motion based methods and features, such as improved trajectories and deep learning features.
A conservative perspective: A critical assessment of Michael Oakeshott's concept of education (1983)

(1983). A conservative perspective: A critical assessment of Michael Oakeshott's concept of education. Irish Educational Studies: Vol. 3, No. 1, pp. 33-46.
A Study on Virtual Local Area Network (VLAN) and Inter-VLAN Routing (2017)

In this paper, we have taken a configuration with 4 L2 switches and 2 L3 switches along with a router to explain the concept of Virtual Local Area Networks and Inter VLAN routing. We have also explained the technology associated with creating VLAN and maintaining VLAN. Static routing is done to provide routing of traffic among different VLAN’s.
Conformationally Constrained Dipeptide Surrogates with Aromatic Side-Chains:  Synthesis of 4-Aryl Indolizidin-9-one Amino Acids by Conjugate Addition to a Common α,ω-Diaminoazelate Enone Intermediate (2004)

Four methyl 9-oxo-8-(N-(Boc)-amino)-4-phenyl-1-azabicyclo[4.3.0]nonane carboxylates (11, 4-Ph-I(9)aa-OMe) were synthesized from (2S,8S,5E)-di-tert-butyl-4-oxo-5-ene-2,8-bis[N-(PhF)amino]azelate [(5E)-7, PhF = 9-(9-phenylfluorenyl)] via a seven-step process featuring a conjugate addition/reductive amination/lactam cyclization sequence. Various nucleophiles were used in the conjugate addition reactions on enone (5E)-7 as a general route for making alpha,omega-diaminoazelates possessing different substituents in good yield albeit low diastereoselectivity except in the case of aryl Grignard reagents (9/1 to 15/1 drs). 6-Phenylazelates (6S)-8d and (6R)-8d were separated by chromatography and diastereoselective precipitation and independently transformed into 4-Ph-I(9)aa-OMe. From (6S)-8d, (2S,4R,6R,8S)-4-Ph-I(9)aa-OMe 11 was prepared selectively in 51% yield. Reductive amination of (6R)-8d provided the desired pipecolates 9 along with desamino compound 10, which was minimized by performing the hydrogenation in the presence of ammonium acetate. Subsequent ester exchange, lactam cyclization, and amine protection provided three products (2R,4S,6S,8R)-, (2R,4S,6S,8S)-, and (2S,4S,6R,8S)-4-Ph-I(9)aa-OMe 11 in 10, 6, and 6% yields, respectively, from (6R)-8d. Ester hydrolysis of (2S,4R,6R,8S)-11 furnished 4-phenyl indolizidin-9-one N-(Boc)amino acid 3 as a novel constrained Ala-Phe dipeptide surrogate for studying conformation-activity relationships of biologically active peptides.
Ryanodine Receptor Expression in the Kidney and a Non-excitable Kidney Epithelial Cell (1996)

An oligonucleotide probe to a conserved 3' region within the three identified ryanodine receptor-calcium release channel isoforms hybridized to a single clone from a rabbit kidney cDNA library. The kidney clone encoded the carboxyl-terminal 338 amino acids within the putative transmembrane domain of the type 2 ryanodine receptor sequence. Reverse transcriptase-polymerase chain reaction with isoform-specific oligonucleotide primers demonstrated the presence of the type 2 ryanodine receptor transcript in rabbit kidney, as well as in a non-excitable cell line, LLC-RK1, derived from rabbit kidney epithelial cells. Amplification by rapid amplification of 5' cDNA ends indicated the kidney type 2 ryanodine receptor transcript extended >7000 base pairs from the stop codon and is therefore not homologous to the short RyR-1 transcript of approximately 2500 base pairs previously observed in rabbit brain. [3H]Ryanodine binding and immunoblot analysis with a type 2 ryanodine receptor-specific antibody demonstrated that the native type 2 ryanodine receptor protein is expressed in the kidney. These observations suggest that the type 2 ryanodine receptor isoform may play a functional role in regulating intracellular calcium homeostasis in non-excitable cells.
White-light imaging by use of a multiple passband acousto-optic tunable filter (1996)

White-light imaging was accomplished by operation of a TeO(2) acousto-optic tunable filter (AOTF) with 40 simultaneous overlapping passbands from 400 to 700 nm. The AOTF was chromatically compensated by a wedge applied to the output surface of the AOTF, and the measured spatial resolution correlated well with predictions. Switching off specific rf's applied to the AOTF produced optical rejection corresponding to the inactive passbands. A rejection ratio of 30 dB was demonstrated, and the rejection level was found to be controlled by leakage through the sidelobes of adjacent passbands.
Concurrent systolic architecture for high-throughput implementation of 3-dimensional discrete wavelet transform (2008)

In this paper, we present a novel systolic architecture for high-throughput computation of 3-dimensional (3-D) discrete wavelet transform (DWT). The entire 3-D DWT computation is decomposed into three distinct stages and implemented concurrently in a linear array of fully pipelined processing elements (PE). The proposed structure for 3-D DWT provides higher throughput than the existing architecture; and involves nearly half or less the number of multipliers and adders; and less on-chip memory (when normalized for unit throughput rate) than the other. Most importantly, the proposed one does not require any frame buffer unlike the other to perform inter-frame DWT computation. The proposed structure has a small latency and can perform 3-D DWT computation with 100% hardware unitization efficiency.
Optimization of operating temperature for continuous glucose isomerase reactor system (1981)

Abstract The Optimal temperature control policy for an immobilized glucose isomerase reactor system was studied. This optimization study takes into consideration the enzyme deactivation during the continuous reactor operation. The Kinetic parameters including reduced Michaelis–Menten constant ( K̄ m ), reduced maximum reaction rate ( V̄ m ), equilibrium constant ( K e ), and enzyme deactivation constant ( k d ) and their functional relationships to temperature were determined experimentally. The optimization problem was formulated in terms of maximization of fructose productivity as the objective function. The optimization problem was solved by making use of a maximum principle and the control vector iteration method. Approximately optimal temperature control policy was employed as compared with the reactor operation at an optimum constant temperature.
Dimensions of P2P and digital piracy in a university campus (2018)

This article presents findings from the first large-scale quantitative assessment of Peer-to-Peer (P2P) exchanges of copyrighted material on a college campus based on actual observation. Through passive monitoring and deep packet inspection (DPI), we assess the extent to which P2P is used to transfer copyrighted material. We also characterize the demographics of P2P users, the relative popularity of the material, and how the burden on the campus network varies over time. We found that at least 51% of students living on campus engaged in P2P, at least 42% attempted to transfer copyrighted material, and the mean number of copyrighted media titles whose transfer is attempted per week was at least 6 per monitored student. Some students use P2P legally, e.g. to transfer Linux software or non-copyrighted adult material, but we found no evidence that large numbers of students use P2P for these legal purposes and not to transfer copyrighted material. Students of all genders, ages, classes and majors engaged in file sharing, to the extent that demographics were not helpful in identifying likely file-sharers so as to target interventions. This study also provides lessons for those who would use DPI technology to reduce illegal use of P2P. If given enough weeks to observe, current technology is effective at identifying users who attempt to transfer copyrighted material, provided that their traffic is identifiable as P2P. Thus, DPI can be used to estimate the extent of piracy, and to notify individuals who may be violating copyright law. However, encryption is available and can be easily activated in most P2P clients. Once turned on, encryption prevents DPI from detecting whether transferred material is copyrighted, rendering it ineffective. If DPI is used for copyright enforcement that includes imposition of penalties, then P2P users or P2P developers may have the incentive to use encryption as a way of evading detection.
Proinflammatory Cytokine Tumor Necrosis Factor (TNF)-like Weak Inducer of Apoptosis (TWEAK) Suppresses Satellite Cell Self-renewal through Inversely Modulating Notch and NF-κB Signaling Pathways (2013)

Satellite cell self-renewal is an essential process to maintaining the robustness of skeletal muscle regenerative capacity. However, extrinsic factors that regulate self-renewal of satellite cells are not well understood. Here, we demonstrate that TWEAK cytokine reduces the proportion of Pax7(+)/MyoD(-) cells (an index of self-renewal) on myofiber explants and represses multiple components of Notch signaling in satellite cell cultures. The number of Pax7(+) cells is significantly increased in skeletal muscle of TWEAK knock-out (KO) mice compared with wild-type in response to injury. Furthermore, Notch signaling is significantly elevated in cultured satellite cells and in regenerating myofibers of TWEAK-KO mice. Forced activation of Notch signaling through overexpression of the Notch1 intracellular domain (N1ICD) rescued the TWEAK-mediated inhibition of satellite cell self-renewal. TWEAK also activates the NF-κB transcription factor in satellite cells and inhibition of NF-κB significantly improved the number of Pax7(+) cells in TWEAK-treated cultures. Furthermore, our results demonstrate that a reciprocal interaction between NF-κB and Notch signaling governs the inhibitory effect of TWEAK on satellite cell self-renewal. Collectively, our study demonstrates that TWEAK suppresses satellite cell self-renewal through activating NF-κB and repressing Notch signaling.
Diabetes and Cardiovascular Disease Executive Summary Conference Proceeding for Healthcare Professionals From a Special Writing Group of the American Heart Association (2002)

Prevention VI: Diabetes and Cardiovascular Disease" on
μ-Conotoxin SmIIIA, a Potent Inhibitor of Tetrodotoxin-Resistant Sodium Channels in Amphibian Sympathetic and Sensory Neurons (2002)

Mu-conotoxins are a family of peptides from the venoms of predatory cone snails. Previously characterized mu-conotoxins preferentially block skeletal muscle voltage-gated sodium channels. We report here the discovery (via cloning), synthesis, and electrophysiological characterization of a new peptide in this family, mu-conotoxin SmIIIA from Conus stercusmuscarum. Although mu-conotoxin SmIIIA shares several biochemical characteristics with other mu-conotoxins (the arrangement of cysteine residues and a conserved arginine believed to interact with residues near the channel pore), it has distinctive features such as the absence of hydroxyproline. In voltage-clamped dissociated neurons from frog sympathetic and dorsal root ganglia, the peptide inhibited the majority of tetrodotoxin-resistant sodium currents irreversibly; in contrast, tetrodotoxin-sensitive sodium currents were largely unaffected by the peptide. We believe that mu-conotoxin SmIIIA is the first specific antagonist of tetrodotoxin-resistant voltage-gated sodium channels to be discovered. Thus, the peptide provides a new and potentially useful tool to investigate the functional roles of tetrodotoxin-resistant voltage-gated sodium channels, including those that are found in sensory nerves that convey nociceptive information.
Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS (2020)

Type I interferon receptor (IFNAR) signaling is a hallmark of viral control and host protection. Here, we show that, in the hippocampus of healthy IFNAR-deficient mice, synapse number and synaptic plasticity, as well as spatial learning, are impaired. This is also the case for IFN-β-deficient animals. Moreover, antibody-mediated IFNAR blocking acutely interferes with neuronal plasticity, whereas a low-dose application of IFN-β has a positive effect on dendritic spine structure. Interfering with IFNAR signaling in different cell types shows a role for cognitive function and synaptic plasticity specifically mediated by astrocytes. Intriguingly, levels of the astrocytic glutamate-aspartate transporter (GLAST) are reduced significantly upon IFN-β treatment and increase following inhibition of IFNAR signaling. These results indicate that, besides the prominent role for host defense, IFNAR is important for synaptic plasticity as well as cognitive function. Astrocytes are at the center stage of this so-far-unknown signaling cascade.