gebhart/patrepeval huggingface dataset:
Current conveyor based EMG amplifier with shutdown control (1991)

A current conveyor implementation of an EMG amplifier with shutdown control is described. The shutdown control allows for measurements on electrically stimulated muscles because the amplifier can be turned off during the stimulation. The implementation using current conveyors makes it possible to perform the shutdown switching at a low impedance node, reducing switching transients to a level which does not cause saturation of the EMG amplifier. Experimental results indicate that the recovery period, required in a traditional EMG amplifier after the stimulation pulse, has been eliminated. The conveyor based amplifier is able to measure the EMG signals accurately immediately after the stimulation pulse.
Generating test cases for GUI responsibilities using complete interaction sequences (2002)

Testing graphical user interfaces (GUI) is a difficult problem due to the fact that the GUI possesses a large number of states to be tested, the input space is extremely large due to different permutations of inputs and events which affect the GUI, and complex GUI dependencies which may exist. There has been little systematic study of this problem yielding a resulting strategy which is effective and scalable. The proposed method concentrates upon user sequences of GUI objects and selections which collaborate, called complete interaction sequences (CIS), that produce a desired response for the user. A systematic method to test these CIS utilizes a finite-state model to generate tests. The required tests can be substantially reduced by identifying components of the CIS that can be tested separately. Since consideration is given to defects totally within each CIS, and the components reduce required testing further, this approach is scalable. An empirical investigation of this method shows that substantial reduction in tests can still detect the defects in the GUI. Future research will prioritize testing related to the CIS testing for maximum benefit if testing time is limited.
3D Sketching using Multi-View Deep Volumetric Prediction (2018)

Sketch-based modeling strives to bring the ease and immediacy of drawing to the 3D world. However, while drawings are easy for humans to create, they are very challenging for computers to interpret due to their sparsity and ambiguity. We propose a data-driven approach that tackles this challenge by learning to reconstruct 3D shapes from one or more drawings. At the core of our approach is a deep convolutional neural network (CNN) that predicts occupancy of a voxel grid from a line drawing. This CNN provides an initial 3D reconstruction as soon as the user completes a single drawing of the desired shape. We complement this single-view network with an updater CNN that refines an existing prediction given a new drawing of the shape created from a novel viewpoint. A key advantage of our approach is that we can apply the updater iteratively to fuse information from an arbitrary number of viewpoints, without requiring explicit stroke correspondences between the drawings. We train both CNNs by rendering synthetic contour drawings from hand-modeled shape collections as well as from procedurally-generated abstract shapes. Finally, we integrate our CNNs in an interactive modeling system that allows users to seamlessly draw an object, rotate it to see its 3D reconstruction, and refine it by re-drawing from another vantage point using the 3D reconstruction as guidance.
A dynamic model for quantifying rail–highway grade crossing roughness (2015)

Annually, more than 2,000 rail–highway crossing crashes in the United States result in nearly 300 fatalities. Crossing roughness is a concern for the motoring public from a comfort and vehicle maintenance perspective, and to highway authorities from a maintenance perspective. Roughness may even increase the risk of crossing crashes. However, with 216,000 rail–highway grade crossings in the United States, maintenance management is a large undertaking. Crossings deteriorate over time, sometimes rapidly, and life-cycle costs increase without preventive maintenance. However, though methods are available to quantify highway roughness, no method exists to quantitatively assess the condition of rail crossings. Because conventional inspection relies on qualitative judgment based on an inspector's perception of the crossing, effect on different vehicles and perception by other drivers are unknown. Further, roughness may be due to as-built geometry, deterioration, or a combination of both. A quantifiable and extensible procedure is thus desired. The article details the use of 3D surface models and a customized vehicle dynamic model to predict accelerations experienced by highway vehicles using the crossing. The model is validated with field-measured accelerations. Results indicate good agreement between modeled and measured accelerations for a test vehicle at several speed ranges at two different locations.
Incorporating biological information in sparse principal component analysis with application to genomic data (2017)

The proposed sparse PCA methods Fused and Grouped sparse PCA can effectively incorporate prior biological information in variable selection, leading to improved feature selection and more interpretable principal component loadings and potentially providing insights on molecular underpinnings of complex diseases.
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles (2017)

Lysosomes serve dual roles in cancer metabolism, executing catabolic programs (i.e., autophagy and macropinocytosis) while promoting mTORC1-dependent anabolism. Antimalarial compounds such as chloroquine or quinacrine have been used as lysosomal inhibitors, but fail to inhibit mTOR signaling. Further, the molecular target of these agents has not been identified. We report a screen of novel dimeric antimalarials that identifies dimeric quinacrines (DQ) as potent anticancer compounds, which concurrently inhibit mTOR and autophagy. Central nitrogen methylation of the DQ linker enhances lysosomal localization and potency. An <i>in situ</i> photoaffinity pulldown identified palmitoyl-protein thioesterase 1 (PPT1) as the molecular target of DQ661. PPT1 inhibition concurrently impairs mTOR and lysosomal catabolism through the rapid accumulation of palmitoylated proteins. DQ661 inhibits the <i>in vivo</i> tumor growth of melanoma, pancreatic cancer, and colorectal cancer mouse models and can be safely combined with chemotherapy. Thus, lysosome-directed PPT1 inhibitors represent a new approach to concurrently targeting mTORC1 and lysosomal catabolism in cancer.<b>Significance:</b> This study identifies chemical features of dimeric compounds that increase their lysosomal specificity, and a new molecular target for these compounds, reclassifying these compounds as targeted therapies. Targeting PPT1 blocks mTOR signaling in a manner distinct from catalytic inhibitors, while concurrently inhibiting autophagy, thereby providing a new strategy for cancer therapy. <i>Cancer Discov; 7(11); 1266-83. ©2017 AACR.</i><i>See related commentary by Towers and Thorburn, p. 1218</i><i>This article is highlighted in the In This Issue feature, p. 1201</i>.
Inhibition of aflatoxin B<sub>1</sub> -hepatocarcinogenesis in rats by β-naphthoflavone (1985)

Effects of beta-naphthoflavone (beta NF) on the activity of hepatic microsomal aflatoxin B1 (AFB1)-4-hydroxylase - the cytochrome P-450-dependent enzyme system which catalyzes the metabolism of AFB1 to AFM1 - and on AFB1-induced in vivo hepatocarcinogenesis were investigated in weanling male Fischer rats. A single i.p. injection of beta NF in doses of 20 mg/kg and 150 mg/kg induced AFB1-4-hydroxylase 3- and 4-fold, respectively, 48 h post injection. Feeding of diet containing 0.01% beta NF for a period of 9-weeks induced AFB1-4-hydroxylase approximately 2-fold. AFB1, given by intubation in a dose of 25 micrograms five times/week for 8 weeks, produced 42 weeks later a 100% incidence of liver lesions (neoplastic foci, nodules or tumors), but feeding beta-NF in diet at a concentration of 0.015% for one week prior to and during the 8 weeks of AFB1 treatment inhibited AFB1 hepatocarcinogenesis by approximately 75%. These results are in accord with the suggestion that AFB1-4-hydroxylase induction may be associated with the inhibition of AFB1 carcinogenesis, possibly occurring as a consequence of accelerated detoxification of AFB1 via its conversion to AFM1.
Increase in Central Retinal Edema after Subthreshold Diode Micropulse Laser Treatment of Chronic Central Serous Chorioretinopathy (2015)

Results. A patient with chronic central serous chorioretinopathy (CSCR) was treated with SDM Yellow multispot laser. Procedure had been preceded by careful titration of the laser power, which after achieving of the threshold parameter was decreased by 50%. The follow-up visit two days after treatment revealed significant central retinal edema and subretinal fluid. Fundus autofluorescence image showed thermal reaction from the RPE in the form of small spots of hyperfluorescence corresponding to the laser multispot pattern used for treatment. Retinal edema resolved after topical bromfenac and single intravitreal bevacizumab injection. Slight pigmentary reaction from the RPE persisted. Conclusion. In the treatment of CSCR, there is a need to significantly reduce threshold SDM power parameters or simply use very low power without titration.
PENERAPAN METODE HYBRID LEARNING PADA MATA PELAJARAN PPKN KELAS II SDN 060921 MEDAN SUNGGAL (2023)

Penelitian ini bertujuan sebagai berikut: (1) untuk mengetahui cara memanfaatkan teknologi yang dapat menunjang proses pembelajaran pada mata pelajaran PPKn, (2) untuk mengetahui penerapan metode hybrid learning pada siswa kelas II SDN 060921 Medan Sunggal, (3) untuk mengetahui cara meningkatkan pemahaman peserta didik dalam memanfaatkan teknologi sebagai fasilitas dan sumber belajar siswa kelas II SDN 060921 Medan Sunggal. Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan kualitatif. Untuk menganalisis penelitian tersebut, peneliti menggunakan pendekatan penelitian kualitatif yang bersifat deskriptif memperoleh data tentang bagaimana penerapan hybrid learning dalam pembelajaran PPKn yang ada di SDN 060921 Medan Sunggal. Adapun teknik pengumpulan data dalam penelitian ini menggunakan teknik observasi, wawancara, dan dokumentasi. Penelitian ini memperoleh hasil kesimpulan: (1) proses penerapan hybrid learning pada mata pelajaran PPKn di SDN 060921 Medan Sunggal menggunakan strategi yang memanfaatkan audio visual learning dan saintifik learning , (2) faktor pendukung penerapan hybrid learning fasilitas sekolah yang sudah memadai, menambah pengetahuan dan kompetensi guru, siswa belajar mandiri, (3) sedangkan faktor penghambatnya adalah terbatasnya waktu, siswa kurang disiplin dalam belajar, fasilitas teknologi yang tidak memadi di rumah.
<i>Hoxa1</i> and <i>Hoxb1</i> synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch (1998)

The analysis of Hoxa1 and Hoxb1 null mutants suggested that these genes are involved in distinct aspects of hindbrain segmentation and specification. Here we investigate the possible functional synergy of the two genes. The generation of Hoxa1(3'RARE)/Hoxb1(3'RARE) compound mutants resulted in mild facial motor nerve defects reminiscent of those present in the Hoxb1 null mutants. Strong genetic interactions between Hoxa1 and Hoxb1 were uncovered by introducing the Hoxb1(3'RARE) and Hoxb1 null mutations into the Hoxa1 null genetic background. Hoxa1(null)/Hoxb1(3'RARE) and Hoxa1(null)/Hoxb1(null )double homozygous embryos showed additional patterning defects in the r4-r6 region but maintained a molecularly distinct r4-like territory. Neurofilament staining and retrograde labelling of motor neurons indicated that Hoxa1 and Hoxb1 synergise in patterning the VIIth through XIth cranial nerves. The second arch expression of neural crest cell markers was abolished or dramatically reduced, suggesting a defect in this cell population. Strikingly, the second arch of the double mutant embryos involuted by 10.5 dpc and this resulted in loss of all second arch-derived elements and complete disruption of external and middle ear development. Additional defects, most notably the lack of tympanic ring, were found in first arch-derived elements, suggesting that interactions between first and second arch take place during development. Taken together, our results unveil an extensive functional synergy between Hoxa1 and Hoxb1 that was not anticipated from the phenotypes of the simple null mutants.
Activation and reaction volumes in solution (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleActivation and reaction volumes in solutionT. Asano and W. J. Le NobleCite this: Chem. Rev. 1978, 78, 4, 407–489Publication Date (Print):August 1, 1978Publication History Published online1 May 2002Published inissue 1 August 1978https://doi.org/10.1021/cr60314a004Request reuse permissionsArticle Views1439Altmetric-Citations475LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (5 MB) Get e-Alertsclose Get e-Alerts
Bio-Inspired Motion Detection for a Blind Spot Overtaking Monitor (2004)

The rear-view mirror is unhelpful when an overtaking car is in the blind quadrants (blind spot). In this contribution we describe the software implementation of an algorithm to monitor vehicle overtaking processes. This algorithm detects the vehicle to the rear, and discriminates whether it is approaching or not, and if approaching, it alerts us of its presence. The proposed system is based on the Reichardt correlator model [1]. The approach presented uses the saliency of motion features in a competition scheme to filter noise patterns. In this way features corresponding to rigid body motion self-emerge from the background. Real overtaking sequences have been to develop this monitoring system.
Extremely deep photopolymerization using upconversion particles as internal lamps (2016)

More than 10 centimeters of photopolymerization depth is obtained using upconversion nanoparticles as internal lamps.
Fifth International Symposium on Domain Decomposition Methods for Partial Differential Equations (1992)

Papers presented at the May 1991 symposium reflect continuing interest in the role of domain decomposition in the effective utilization of parallel systems; applications in fluid mechanics, structures, biology, and design optimization; and maturation of analysis of elliptic equations, with theoretic
The Mediation Effect of Life Satisfaction Between Aggression and Loneliness in Children and Adolescents (2012)

This study examined the mediation effect of life satisfaction between aggression and loneliness. The subjects were two hundred and eighty fifth-year elementary school and second-year middle school adolescents in Seoul. Data were analyzed by using the t-test, Pearson's correlation and regression. Major findings were as follows: First, when it comes to aggressiveness, the fifth graders showed a significantly higher degree of personal attack, whereas the eighth graders were found to show more expression of anger. The fifth graders scored higher than the eighth graders in each subcategory of life satisfaction. No significant difference was found in the category of loneliness. Second, the fifth graders showed a positive relationship among verbal attack, personal attach, expression of anger and loneliness, whereas the eighth graders showed a positive relationship between expression of anger and loneliness. The two age groups, in turn, also exhibited some differences in the relationship between loneliness and life satisfaction. Third, we found that life satisfaction is a complete parameter between aggressiveness and loneliness in the fifth graders. In the case of the eighth graders, life satisfaction turned out to be a partial parameter between aggressiveness and loneliness. This perhaps indicates that adolescents with similar levels of aggressiveness might show different degrees of loneliness, depending on whether they have positive attitudes toward their lives and whether they feel satisfied with their lives.
Densities and Viscosities of 1-Butyl-3-methylimidazolium Trifluoromethanesulfonate + H<sub>2</sub>O Binary Mixtures at <i>T</i> = (303.15 to 343.15) K (2008)

Densities and viscosities for the binary mixtures of H2O (1) + 1-butyl-3-methylimidazolium trifluoromethanesulfonate ([BMIM][CF3SO3]) (2) were measured over the entire mole fraction range from (303.15 to 343.15) K at atmospheric pressure. Excess molar volumes and viscosity deviations as a function of mole fraction average were derived, and the results were fitted to the Redlich−Kister equation using a multiparametric nonlinear regression method. Estimated coefficients of the Redlich−Kister equation and standard error calculated from the Redlich−Kister equation to the experimental data are also presented. The results show that the densities and viscosities are dependent on water content and temperature.
Shoulder Pain in Hemiplegia (1985)

Development of a painful shoulder in the hemiplegic patient is a significant and serious problem, because it can limit the patient's ability to reach his or her maximum functional potential. Several etiologies of shoulder pain have been identified, such as immobilization of the upper extremity, trauma to the joint structures, including brachial plexus injuries, and subluxation of the gleno-humeral joint. A review of the literature explains the basic anatomy and kinesiology of the shoulder complex, the various etiologies of hemiplegic shoulder pain, and the pros and cons of specific treatment techniques. This knowledge is essential for the occupational therapist to evaluate effectively techniques used to treat the patient with hemiplegic shoulder pain. More effective management of this problem will facilitate the patient's ability to reach his or her maximum functional potential.
New Pyridone Approach:  Total Synthesis of Mappicine Ketone (Nothapodytine B) (2000)

A novel synthesis of mappicine ketone, which possesses strong selective activity against the herpes viruses HSV-1 and HSV-2, including those Acyclovir-resistant, and human cytomegalovirus (HCMV) has been efficiently accomplished. The synthesis highlights a new pyridone approach that effectively combines a double, intramolecular Michael addition in a conjugated ester-conjugated amide with oxidation-decarboxylation of the resulting piperidone.
Timing molecular motion and production with a synthetic transcriptional clock (2011)

The realization of artificial biochemical reaction networks with unique functionality is one of the main challenges for the development of synthetic biology. Due to the reduced number of components, biochemical circuits constructed in vitro promise to be more amenable to systematic design and quantitative assessment than circuits embedded within living organisms. To make good on that promise, effective methods for composing subsystems into larger systems are needed. Here we used an artificial biochemical oscillator based on in vitro transcription and RNA degradation reactions to drive a variety of "load" processes such as the operation of a DNA-based nanomechanical device ("DNA tweezers") or the production of a functional RNA molecule (an aptamer for malachite green). We implemented several mechanisms for coupling the load processes to the oscillator circuit and compared them based on how much the load affected the frequency and amplitude of the core oscillator, and how much of the load was effectively driven. Based on heuristic insights and computational modeling, an "insulator circuit" was developed, which strongly reduced the detrimental influence of the load on the oscillator circuit. Understanding how to design effective insulation between biochemical subsystems will be critical for the synthesis of larger and more complex systems.
Soft Robotics in Minimally Invasive Surgery (2019)

Soft robotic devices have desirable traits for applications in minimally invasive surgery (MIS), but many interdisciplinary challenges remain unsolved. To understand current technologies, we carried out a keyword search using the Web of Science and Scopus databases, applied inclusion and exclusion criteria, and compared several characteristics of the soft robotic devices for MIS in the resulting articles. There was low diversity in the device designs and a wide-ranging level of detail regarding their capabilities. We propose a standardized comparison methodology to characterize soft robotics for various MIS applications, which will aid designers producing the next generation of devices.
Simulation of magnetic field distribution of excitation coil for EM flow meter and its validation using magnetic camera (2008)

Distribution of magnetic flux density in electromagnetic (EM) flow meter is significantly important for obtaining accurate flow rate. Analysis of Helmholtz coils used to generate homogeneous magnetic flux density in the cross section of flow pipe of electromagnetic (EM) flow meter is presented in this paper. In this work a simulation model with the EM module of finite element analysis software, COMSOL, is built and experimental testing of the distribution of magnetic flux density is applied to verify its uniformity. A 2D magnetic camera system with 64 Hall sensors is prototyped. The magnetic field data are picked up by the National Instruments PCI 6255 data acquisition card.The results from the simulation and measurements are presented and compared in the paper. The study helps to design the electrode sensor arrays of EM flow meter. In addition to this, the distribution data of magnetic flux density are useful for the improvement of accurate flow rate measurement of EM flow meter.
Oxygen-atom transfer to a nucleophilic molybdenum complex (2010)

The reactivity of the imido-Mo(IV) species [(eta(5)-Cp)(2)Mo(N(t)Bu)], 1, towards the iodine-based oxidant PhIO was investigated and yielded the micro-oxodimolybdenum(V) dimer [{(eta(5)-Cp)(eta(1)-Cp)Mo(N(t)Bu)}(2)O], 2. X-Ray crystallography and (1)H-NMR of 2 indicate slipping of one of the eta(5)-Cp ring on each Mo center to eta(1)-Cp as the result of the coordination of the oxygen atom. DFT investigation of the OAT reaction to complex 1 revealed a transient Mo(IV)-oxo species as the most likely intermediate.