gebhart/patrepeval huggingface dataset:
Identification of <i>N</i>‐acetylgalactosamine‐containing glycoproteins PEB3 and CgpA in <i>Campylobacter jejuni</i> (2002)

It was demonstrated recently that there is a system of general protein glycosylation in the human enteropathogen Campylobacter jejuni. To characterize such glycoproteins, we identified a lectin, Soybean agglutinin (SBA), which binds to multiple C. jejuni proteins on Western blots. Binding of lectin SBA was disrupted by mutagenesis of genes within the previously identified protein glycosylation locus. This lectin was used to purify putative glycoproteins selectively and, after sodium dodecyl sulphatepolyacrylamide gel electrophoresis (SDS-PAGE), Coomassie-stained bands were cut from the gels. The bands were digested with trypsin, and peptides were identified by mass spectrometry and database searching. A 28kDa band was identified as PEB3, a previously characterized immunogenic cell surface protein. Bands of 32 and 34kDa were both identified as a putative periplasmic protein encoded by the C. jejuni NCTC 11168 coding sequence Cj1670c. We have named this putative glycoprotein CgpA. We constructed insertional knockout mutants of both the peb3 and cgpA genes, and surface protein extracts from mutant and wild-type strains were analysed by one- and two-dimensional polyacrylamide gel electrophoresis (PAGE). In this way, we were able to identify the PEB3 protein as a 28 kDa SBA-reactive and immunoreactive glycoprotein. The cgpA gene encoded SBA-reactive and immunoreactive proteins of 32 and 34 kDa. By using specific exoglycosidases, we demonstrated that the SBA binding property of acid-glycine extractable C. jejuni glycoproteins, including PEB3 and CgpA, is a result of the presence of alpha-linked N-acetylgalactosamine residues. These data confirm the existence, and extend the boundaries, of the previously identified protein glycosylation locus of C. jejuni. Furthermore, we have identified two such glycoproteins, the first non-flagellin campylobacter glycoproteins to be identified, and demonstrated that their glycan components contain alpha-linked N-acetylgalactosamine residues.
Successful interrupted feeding of adult <i>Rhipicephalus appendiculatus</i> (Ixodidae) is accompanied by re-programming of salivary gland protein expression (1999)

Ixodid female ticks take one comparatively large bloodmeal which they convert to a single large egg mass and then they die. To examine the outcome of interrupted feeding, equal numbers of male and female Rhipicephalus appendiculatus adult ticks were fed on guinea pigs (host 1) for either 2, 4, or 6 days, or to engorgement (8 days). All of the fully engorged (D8) females laid a single large egg mass (80-160 mg/tick), while 85% of the day 6-fed (D6) female ticks (n = 20) each laid a small egg mass (6.1 mg/tick). None of the females that had fed for 2 or 4 days oviposited. Ninety percent (n = 20) of the day 2-fed (D2) females survived for 4 weeks after their feeding was interrupted, whereas 65% (n = 20) of the day 4-fed (D4) females survived. All of the surviving partially fed female ticks (D2 and D4) attached to a second guinea pig (host 2) and attained engorged body weights that were not significantly different from those of the control females (P < 0.05). Female ticks that engorged following interrupted feeding layed egg masses comparable to the controls, indicating that engorgement on host 2 was successful. The salivary gland protein profile of female ticks changed constantly during feeding. However, when feeding was interrupted, the protein expression pattern switched back to that of the non-parasitic state, presumably to enable the partially fed ticks to survive and reattach on the new host. This observation indicates that female ixodid ticks have a natural ability to survive and re-establish successful feeding on a new host if the first attempt at feeding is unsuccessful. Such an interrupted feeding mechanism supports the hypothesis that partially engorged ticks may play a role in tick-borne pathogen transmission.
Period-Doubling and Quadrupling Bifurcation of Vector Soliton Bunches in a Graphene Mode Locked Fiber Laser (2017)

Period-doubling bifurcation and period-quadrupling bifurcation of vector soliton pulses in a graphene mode locked fiber laser is experimentally observed and investigated. Not only single vector soliton but also vector soliton bunches as a unity are found to exhibit period-doubling and period-quadrupling bifurcation. The experimental results suggest that period-doubling and quadrupling bifurcation are intrinsic features of the pulses circulating in a nonlinear ring cavity, which are independent of the properties of the mode-locker in the fiber lasers.
Synergy between Ceria Oxygen Vacancies and Cu Nanoparticles Facilitates the Catalytic Conversion of CO<sub>2</sub> to CO under Mild Conditions (2018)

The performance of supported metal catalysts can depend on many factors, including metal particle size and dispersion and metal–support interactions, and differentiation of these effects is challenging because of their interwoven relationship. Copper/ceria catalysts are well-known redox catalysts studied in the conversion of CO and CO2 via oxidation and/or reduction pathways. The redox behaviors of each species, Cu-CuO and CeOx-CeO2, are often suggested to be interlinked, allowing ceria-supported copper domains to outperform copper species on other, nonredox active supports. In this work, the catalytic activity of nanosized Cu supported on either cerium oxide or mesoporous silica is explored using samples where the Cu weight loading, particle size, and dispersion of Cu are held constant to highlight the impact of the two supports on catalytic performance without additional influencing factors. The Cu/CeO2 catalysts are synthesized via a space-confined method to limit the growth of CeO2 particles and to achieve a high dispersion of Cu. Through in situ XRD and XAS, it is shown that the presence of Cu nanoparticles on the CeO2 support lowers the reduction temperature of CeO2, allowing formation of oxygen vacancies at low temperatures <300 °C. The Cu/CeOx catalyst demonstrates 100% CO selectivity in the low temperature (300 °C) and ambient pressure conversion of CO2 to CO, even when approaching equilibrium conversion. Moreover, this catalyst is approximately 4 times more active than the corresponding Cu/SiO2 catalyst with otherwise similar structural attributes. The potential reaction pathways are probed by in situ FTIR and in situ XAS at various temperatures, identifying Cu+-CO species and oxygen vacancies forming under some conditions. The collected experimental evidence also suggests a reaction sequence for CO2 hydrogenation over Cu/CeOx catalysts, consistent with DFT reports in the literature.
A new translocation, t(10;14)(q24;q11), in T cell neoplasia (1986)

Four cases of T cell neoplasia are reported: three presenting as T cell acute lymphoblastic leukemia and one presenting in the leukemic phase of a T cell lymphoma. In all cases, the cells of the leukemic clone were characterized by an identical cytogenetic abnormality. This abnormality was a unique reciprocal translocation involving chromosomes 10 and 14. The breakpoint in chromosome 14 was in band q11, coincident with the assigned locus of the alpha-chain gene of the T cell antigen receptor. The breakpoint in chromosome 10 was in band q24, a region reported to include the locus of the terminal deoxynucleotidyltransferase (TdT) gene. Our observations suggest that translocation t(10;14)(q24;q11) is specific for T cell neoplasia and that a gene in chromosomal band 10q24, possibly the TdT gene, plays an important role in T cell neoplasia when its expression or coding sequence is altered by aberrant recombination involving a T cell antigen receptor gene.
New Small-Molecule Glycoconjugates of Docetaxel and GalNAc for Targeted Delivery to Hepatocellular Carcinoma (2020)

In this work, we have developed covalent and low molecular weight docetaxel delivery systems based on conjugation with <i>N</i>-acetyl-d-galactosamine and studied their properties related to hepatocellular carcinoma cells. The resulting glycoconjugates have an excellent affinity to the asialoglycoprotein receptor (ASGPR) in the nanomolar range of concentrations and a high cytotoxicity level comparable to docetaxel. Likewise, we observed the 21-75-fold increase in water solubility in comparison with parent docetaxel and prodrug lability to intracellular conditions with half-life values from 25.5 to 42 h. We also found that the trivalent conjugate possessed selective toxicity against hepatoma cells vs control cell lines (20-35 times). The absence of such selectivity in the case of monovalent conjugates indicates the effect of ligand valency. Specific ASGPR-mediated cellular uptake of conjugates was proved in vitro using fluorescent-labeled analogues. In addition, we showed an enhanced generation of reactive oxygen species in the HepG2 cells, which could be inhibited by the natural ligand of ASGPR. Overall, the obtained results highlight the potential of ASGPR-directed cytostatic taxane drugs for selective therapy of hepatocellular carcinoma.
Thermal Stability of Portable Microtubular SOFCs and Stacks (2008)

Rapid start-up times are a big challenge for high-temperature fuel cells such as solid oxide fuel cells (SOFCs), especially large-sized stacks with high power outputs. This paper presents the development of tubular and microtubular anode-supported SOFCs and the design and testing of the thermal stability of such single cells and stacks. It was demonstrated that single cells with various sizes have very good thermal shock resistance. Preliminary results also showed that stacks can be started up within minutes and withstand more than 50 thermal cycles and that single cells can withstand temperature changes of . Several factors that affect the thermal stability are discussed.
Efficacy assessment of Quwenling, a mosquito repellent from China. (1991)

Quwenling, an insect repellent product of China derived from extracts of the lemon eucalyptus plant (Eucalyptus maculata citriodon), was evaluated. Laboratory tests compared Quwenling with deet against Anopheles albimanus, An. quadrimaculatus, Aedes aegypti, Ae. albopictus and field tests with Ae. taeniorhynchus. Cloth treated with Quwenling at greater than 2x the dosage of deet was effective against 2 of 4 species tested (Ae. albopictus 29 days, An. quadrimaculatus 28 days). On the skin of volunteers at 2x the dosage of deet, the duration of protection for Quwenling was significantly less than deet with Ae. aegypti and Ae. taeniorhynchus, and was not significantly different with Ae. albopictus. Both repellents were ineffective against the anopheline species. As a topically applied mosquito repellent, Quwenling has a shorter duration of effectiveness than deet.
A Reasoning Method Of Cyber-Attack Attribution Based On Threat Intelligence (2016)

With the increasing complexity of cyberspace security, the cyber-attack attribution has become an important challenge of the security protection systems. The difficult points of cyber-attack attribution were forced on the problems of huge data handling and key data missing. According to this situation, this paper presented a reasoning method of cyber-attack attribution based on threat intelligence. The method utilizes the intrusion kill chain model and Bayesian network to build attack chain and evidence chain of cyber-attack on threat intelligence platform through data calculation, analysis and reasoning. Then, we used a number of cyber-attack events which we have observed and analyzed to test the reasoning method and demo system, the result of testing indicates that the reasoning method can provide certain help in cyber-attack attribution.
High performance and reliable strained SiGe PMOS FinFETs enabled by advanced gate stack engineering (2017)

Strained-SiGe, with high-Ge-content, has recently drawn significant attention as an alternate p-channel option for advance FinFETs. Among various technological challenges, gate stack is so critical to enable high-performance FETs. In this paper, key process details of the optimized gate stacks in high-Ge SiGe, such as IL formation and passivation, are disclosed and feasibility of Vth tuning by an ultra-thin replacement metal-gate scheme down to 15nm LG is demonstrated, for the first time. Moreover, near ideal SS, excellent reliability and mobility at scaled EOTs are achieved, which has led to high transconductance devices with proper junction engineering. In addition, we demonstrate the most aggressively-scaled SiGe fins reported to date formed by 3D-Ge-condensation, exhibiting excellent short-channel characteristics.
Ionothermal Synthesis of Triazine–Heptazine‐Based Copolymers with Apparent Quantum Yields of 60 % at 420 nm for Solar Hydrogen Production from “Sea Water” (2018)

Polymeric carbon nitride (PCN), in either triazine or heptazine form, has been regarded as a promising metal-free, environmentally benign, and sustainable photocatalyst for solar hydrogen production. However, PCN in most cases only exhibits moderate activity owing to its inherent properties, such as rapid charge carrier recombination. Herein we present a triazine-heptazine copolymer synthesized by simple post-calcination of PCN in eutectic salts, that is, NaCl/KCl, to modulate the polymerization process and optimize the structure. The construction of an internal triazine-heptazine donor-acceptor (D-A) heterostructure was affirmed to significantly accelerate interface charge transfer (CT) and thus boost the photocatalytic activity (AQY=60 % at 420 nm). This study highlights the construction of intermolecular D-A copolymers in NaCl/KCl molten salts with higher melting points but in the absence of lithium to modulate the chemical structure and properties of PCN.
An extended genetic rule induction algorithm (2002)

Describes an extension of a genetic algorithm (GA) based separate-and-conquer propositional rule induction algorithm called SIA (Supervised Inductive Algorithm). While the original algorithm is computationally attractive and is also able to handle both nominal and continuous attributes efficiently, our algorithm further improves it by taking into account recent advances in the rule induction and evolutionary computation communities. The refined system has been compared to other GA-based and non-GA-based rule learning algorithms on a number of benchmark data sets from the UCI (University of California, Irvine) machine learning repository. The results show that the proposed system can achieve higher performance while still producing a smaller number of rules.
Dye cell design for high-power low-divergence excimer-pumped dye lasers (1981)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text D. S. Bethune, "Dye cell design for high-power low-divergence excimer-pumped dye lasers," Appl. Opt. 20, 1897-1899 (1981) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Activation of Clotting Factor XI Without Detectable Contact Activation in Experimental Human Endotoxemia (1998)

Abstract Evidence of factor XI (FXI) activation in vivo is scarce. In addition, it remains uncertain whether thrombin, factor XIIa (FXIIa), or perhaps another protease is responsible for FXI conversion. We investigated the activation of FXI in eight healthy volunteers after infusion of a low dose of endotoxin (4 ng/kg of body weight). Activation of prekallikrein FXII, FXI, and prothrombin was measured with sensitive enzyme-linked immunosorbent assays (ELISAs), and FXI activation was measured with a novel enzyme capture assay that detects noncomplexed FXIa. Activation of FXI was apparent with a significant plasma peak level of noncomplexed FXIa of 10 to 11 pmol/L at 1 and 2 hours after endotoxin infusion, followed by a gradual increase in FXIa-FXIa inhibitor complexes, measured in the ELISAs, with a summit of 11 to 15 pmol/L at 6 and 24 hours, respectively. In accordance with previous studies, thrombin generation was detected 1 hour after endotoxin infusion to become maximal after 3 to 4 hours. In contrast, we did not find any evidence of contact activation, because markers of activation of prekallikrein and FXII remained undetectable. From the FXIa data a theoretical model was constructed which suggested that inhibition of FXIa does not take place in the plasma compartment, but is localized on a surface. These data provide the first evidence for FXI activation in low-grade endotoxemia and suggest that FXI is activated independently of FXII. © 1998 by The American Society of Hematology.
In the News (2021)

Welcome to the April 2021 issue of C&RL News. In the latest installment of our International Insights column, “Learning from each other,” Diljit Singh of the University of Malaysia reflects on the role of academic libraries in the promotion of international understanding, especially in the time of COVID-19.
Health-related quality of life and concerns in patients attending an oral and maxillofacial oncology review clinic: late effects 5- and 10-year following cancer diagnosis (2022)

Background: An increasing number of head and neck cancer (HNC) patients survive many years after treatment. They are at risk of developing late effects and these could be associated with worse health-related quality of life (HRQOL) and influence the nature of any concerns they want to discuss in consultations. The aim of this study was to report their HRQOL and concerns at oral and maxillofacial oncology review clinics, from 5-and 10-year after primary cancer diagnosis. Methods: The University of Washington quality of life questionnaire (UW-QOL v4) and Patient Concerns Inventory (PCI) were completed by patients attending review clinics from 4th June 2008 to 11th March 2020.
Architecture of on integrated GSM‐satellite system (1994)

Abstract The integration of satellite systems with cellular networks permits to provide wider and more efficient area coverage. This paper deals with the network aspects related to a full integration between the Global System for Mobile communications (GSM) pan‐European cellular network and a spot‐beam geostationary satellite. The basic requirements of full integration are that the insertion of the satellite system does not entail any modification on the already existing GSM network and that the satellite system reuses, as far as possible, the same equipment and protocols, i.e. the same hardware and software, as the GSM network. In the fully integrated system the user need not be aware whether the actual connection goes through the satellite or the cellular network. In particular, this paper identifies the satellite system counterpart of the GSM functional areas (cell, location area, MSC area, PLMN area) and deals with the problems and the relevant solutions related to the extension of the GSM procedures (e.g. call set‐up, cell selection/reselection, handover, initial acquisition, tracking) to the integrated network. This paper is partly based upon the work performed by the author in the framework of an European Space Agency (ESA) study on the compatibility between satellite systems and the GSM cellular network (Telespazio is the prime contractor of this study) and partly results from the cooperation of the author with the INFOCOM department of the University of Rome “La Sapienza”. The opinions herewith reported are not necessarily those of ESA.
Role of ciclosporin in steroid-responsive sudden sensorineural hearing loss (2005)

Steroid-dependent SNHL was confirmed on audiological evaluation. Ciclosporin was administered, allowing corticosteroid therapy to be discontinued. Ciclosporin was effective at controlling all symptoms of SNHL. Remission was confirmed objectively with pure-tone audiometry.
Toxic vessel reaction to an absorbable polymer-based paclitaxel-eluting stent in pig coronary arteries. (2006)

Despite in vitro data showing slow, sustained release of paclitaxel from a bioabsorbable polymer, the porcine coronary artery model demonstrated a sequence of medial necrosis, stent malapposition and late neointimal thickening. Since the therapeutic window for paclitaxel may be narrower than currently inferred, thorough preclinical testing coupled with the polymer development process for stents eluting paclitaxel is needed.
Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species (2015)

Tat-NR2B9c, a clinical-stage stroke neuroprotectant validated in rats and primates, was recently deemed ineffective in mice. To evaluate this discrepancy, we conducted studies in mice subjected to temporary middle cerebral artery occlusion (tMCAO) for either 30 or 60 min according to the established principles for dose-translation between species. Tat-NR2B9c treatment reduced infarct volume by by 24.5% (p = 0.49) and 26.0% (p = 0.03) for 30 and 60 min tMCAO, respectively, at the rat-equivalent dose of 10 nMole/g, but not at the previously reported 3 nMole/g in mice. Dose translation is thus critical when preclinical experiments are conducted in new species.
Criteria for defining a complete remission in acute myeloid leukaemia revisited. An analysis of patients treated in HOVON‐SAKK co‐operative group studies (2004)

Complete remission (CR) in patients with acute myeloid leukaemia (AML) is the primary endpoint for the evaluation of induction treatment and treatment strategies. However, the choice and application of the criteria for a haematological CR can often become a subject of debate because of regeneration more than 5% blasts may be present at the time of response evaluation; platelet and neutrophil recovery may be incomplete and marrow cellularity can vary. This study examined the individual parameters for CR in 1250 adult patients with de novo AML treated according to three successive study protocols. Patients with < or =5% blasts showed the best overall survival (OS) and the lowest relapse risk (RR). This was independent of blast cells present in the peripheral blood or bone marrow (BM) cellularity. In the same patient group, the presence of extramedullary leukaemia, incomplete platelet (<100 x 10(9)/l) or neutrophil (<1.0 x 10(9)/l) recovery caused a reduced OS and increased RR. In conclusion, < or =5% blasts in the BM, recovery of neutrophils and platelets, and the absence of extramedullary disease constitute the cornerstones for the definition of a haematological CR in patients with AML.
Carboranylporphyrins and uses thereof (2023)

The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing 5, 10, 15, 20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head, neck, and surrounding tissue. The invention is also directed to using these carborane-containing tetraphenyl porphyrin compounds to methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.