gebhart/patrepeval huggingface dataset:
Noninvasive detection of macular pigments in the human eye (2004)

There is currently strong interest in developing noninvasive technologies for the detection of macular carotenoid pigments in the human eye. These pigments, consisting of lutein and zeaxanthin, are taken up from the diet and are thought to play an important role in the prevention of age-related macular degeneration, the leading cause of blindness in the elderly in the Western world. It may be possible to prevent or delay the onset of this debilitating disease with suitable dietary intervention strategies. We review the most commonly used detection techniques based on heterochromatic flicker photometry, fundus reflectometry, and autofluorescense techniques and put them in perspective with recently developed more molecule-specific Raman detection methods.
Filters and Components With Inductance Cancellation (2004)

Electrical filters are important for attenuating electrical ripple, eliminating electromagnetic interference (EMI) and susceptibility, improving power quality, and minimizing electromagnetic signature. Capacitors are critical elements in such filters, and filter performance is strongly influenced by the capacitor parasitics. This paper introduces a new design technique that overcomes the capacitor parasitic inductance that limits filter performance at high frequencies. Coupled magnetic windings are employed to effectively cancel the parasitic inductance of capacitors, and to add inductance in filter branches where it is desired. The underlying basis of the new technique is treated in detail, and its application to the design of both discrete filters and integrated LC filter components is described. Numerous experimental results demonstrating the high performance of the approach in both discrete filters and integrated filter elements are provided.
Biomimetic Production of Silk-Like Recombinant Squid Sucker Ring Teeth Proteins (2014)

The sucker ring teeth (SRT) of Humboldt squid exhibit mechanical properties that rival those of robust engineered synthetic polymers. Remarkably, these properties are achieved without a mineral phase or covalent cross-links. Instead, SRT are exclusively made of silk-like proteins called "suckerins", which assemble into nanoconfined β-sheet reinforced supramolecular networks. In this study, three streamlined strategies for full-length recombinant suckerin protein production and purification were developed. Recombinant suckerin exhibited high solubility and colloidal stability in aqueous-based solvents. In addition, the colloidal suspensions exhibited a concentration-dependent conformational switch, from random coil to β-sheet enriched structures. Our results demonstrate that recombinant suckerin can be produced in a facile manner in E. coli and processed from mild aqueous solutions into materials enriched in β-sheets. We suggest that recombinant suckerin-based materials offer potential for a range of biomedical and engineering applications.
Formation of Endogenous “Antiinflammatory” Lipid Mediators by Transcellular Biosynthesis: Lipoxins and Aspirin-triggered Lipoxins Inhibit Neutrophil Recruitment and Vascular Permeability (2000)

Neutrophil-dependent vascular injury gives rise to increased vascular permeability, edema, and further release of chemoattractants. Leukotriene B 4 (LTB 4 ) is among the most potent neutrophil stimuli and thus participates in tissue injury via recruiting neutrophils (PMNs, polymorphonuclear leukocytes) in pathophysiologic scenarios (1). Lipoxins are trihydroxytetraene-containing eicosanoids that are, among other in vivo sites, also generated within vascular lumen primarily by platelet-leukocyte interactions by pathways (Figure 1) that are activated during multicellular responses such as inflammation, atherosclerosis, and thrombosis (for a review, see Reference 2). In addition, aspirin has been found to trigger the transcellular biosynthesis of a new group of compounds termed 15-epi-lipoxins (15-epi-LXs) or aspirin-triggered lipoxins, which are likely to contribute to some of the beneficial actions ascribed to aspirin by serving as local endogenous antiinflammatory lipid mediators (2). Thus, these LX branches illustrated in Figure 1 involve cell-cell interactions that appear to produce endogenous stop signals or antiinflammatory compounds, while the 5-lipoxygenase pathway generates leukotrienes that evoke cellular events that are considered to be proinflammatory.
Detection of Bax Microsatellite Mutations and BaxÃÂ2 Isoform in Human Buccal Cells (2015)

Loss of the pro-apoptotic Bcl-2 family protein Bax occurs in ~50% of hereditary nonpolyposis colorectal cancer (HNPCC) due to microsatellite instability (MSI). Recently, we found that some of the "Bax-negative" MSI tumor cells contain a functional Bax isoform, BaxΔ2, which sensitizes cells to selective chemotherapeutics. Here we show the detection of Bax microsatellite mutations and expression of BaxΔ2 proteins in human buccal cells. Our study provides a sensitive and non-invasive approach and a potential clinical application in diagnosis and treatment of MSI colon cancer patients.
Safety, feasibility and functionality of activated autologous dendritic cells for intratumoral injection in solid tumors: a Phase I clinical trial (2015)

Meeting abstracts Dendritic cells (DC) are proficient in initiating adaptive immune responses, through the uptake and subsequent presentation to the immune system of antigenic compounds. In preclinical studies, activated DC (aDC; DCVax®-Direct) were shown to be superior to immature DC in clearing
Lithium Potassium Manganese Mixed Metal Oxide Material for Rechargeable Electrochemical Cells (2010)

Abstract : A family of potassium-doped manganese oxide materials were synthesized with the stoichiometric formula Li0.9-xKxMn2O4, where X = 0.0 to 0.25, and evaluated for their viability as a cathode material for a rechargeable lithium battery. A performance maximum was found at X = 0.1 where the initial specific capacity for the lithium - potassium doped manganese dioxide electrochemical couple was 130 mAhrs/g of active cathode material.
An all-subthreshold, 0.75V supply, 2ppm/&#x00B0;C, CMOS Voltage Reference (2013)

An all-subthreshold CMOS Voltage Reference architecture is presented, which achieves 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> order curvature compensation over a wide temperature range. The simulated performance of the proposed architecture with a supply voltage of 0.75V is 2 ppm/°C, over a temperature range of 190 °C (-45 °C to 145 °C). The high order curvature compensation is performed using the non-linearities of an NMOS device, operated in subthreshold, combined with the non-linearities of low-temperature-coefficient poly resistors and high-resistivity poly resistors. The topology achieves a power consumption of 2μW. The design does not require any external components.
New high-potency L-aspartyl-3-bicycloalkyl-L-alanine methyl ester sweeteners (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew high-potency L-aspartyl-3-bicycloalkyl-L-alanine methyl ester sweetenersGeorge A. King III, James G. Sweeny, and Guillermo A. IacobucciCite this: J. Agric. Food Chem. 1991, 39, 1, 52–56Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/jf00001a009https://doi.org/10.1021/jf00001a009research-articleACS PublicationsRequest reuse permissionsArticle Views88Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Recent progress in SOFC anodes for direct utilization of hydrocarbons (2007)

There would be significant advantages to having anodes for solid oxide fuel cells (SOFCs) that were capable of directly utilizing hydrocarbon fuels. Because conventional Ni-based anodes catalyze the formation of carbon fibers, new anode compositions are required for this application, but most of the materials that have been proposed exhibit either limited thermal stability or poor electrochemical activity. In this paper, we will describe two strategies for the development of new anodes with improved performance. The first strategy involves the use of bimetallic compositions with layered microstructures. In the bimetallic anodes, one metal is used for thermal stability while the other provides the required carbon tolerance. The second strategy involves separating the anode into two layers: a thin functional layer for electrocatalysis and a thicker conduction layer for current collection. With this approach, the functional layer can be optimized for catalytic activity and, if it is thin enough, requires minimal conductivity. Examples are shown for each of these approaches and possible future directions are outlined.
Seismic Isolation with a new Friction-Viscoelastic Damping System (2004)

This work presents a study on the parameters that govern the performance of a friction-viscoelastic damping system for base isolation of structures. This system is based on a friction-viscoelastic damper made of a friction damper extended with a viscoelastic unit. The device is designed to dissipate seismic input energy and protect buildings from structural and nonstructural damage during moderate and severe earthquakes.
Evaluating Receiver Architectures for Inertial Aiding and Coasting (2007)

In addition to Galileo core services, a set of end-user combined services using different technologies, such as GBAS, SBAS and Inertial Systems, will allow the deployment of added value services resulting in an overall enhanced navigation performance. The use of inertial aiding and coasting of the Galileo or Galileo/GPS receivers using low cost MEMS miniature Inertial Measurement Units (IMU), which can be seamlessly and transparently integrated into GNSS receiver antennas, will significantly contribute to reach improved performances. Hence, new perspectives for future generation of receivers will be open. In this paper we present the results achieved using tightly coupled architecture, also termed deeply coupled, under different scenarios, using aiding and coasting techniques for Galileo signals. Aiding refers to the use of inertialderived position and velocity to aid the receiver tracking loops. Coasting refers to the use of inertial-derived position and velocity for short periods of time due to signal outages. The superior performance of such architecture is specially suited for receivers operating in demanding environments; for instance, urban scenarios, where signal blockage is frequent, and high dynamics, such as accelerating trains. Also important is the contribution in the reduction of the total error budget and increased robustness of satellite signal tracking, ultimately allowing to explore new applications and new possibilities of GNSS. The work is a follow-up of the IADIRA study for the Galileo Joint Undertaking 2nd Call, conducted by DEIMOS Engenharia and the Institute of Geomatics. The hybrid receiver has been implemented in the GRANADA software receiver, and further testing activities have been performed with new data and longer simulations, allowing to quantify how a higher level of integration can lead to better results, including increasing the GNSS output frequency to reduce both filter stabilisation period and navigation solution divergence.
A RETURN MAP REGRESSION APPROACH FOR NONCOHERENT DETECTION IN CHAOTIC DIGITAL COMMUNICATIONS (2003)

Chaos-based communications can be applied advantageously if the property of chaotic systems is suitably exploited. In this Letter a simple noncoherent detection method for chaos-shift-keying (CSK) modulation is proposed, exploiting some distinguishable property of chaotic maps for recovering the digital message. Specifically, the proposed method exploits the difference in the return maps of the signals representing the digital symbols. The determining parameter of the return maps is estimated using a simple regression algorithm. If the parameter strongly characterizes the chaotic map, the detection can achieve very good accuracy. This strong parametric characterization can be achieved by defining the regression model with only one parameter. Using the tent maps as chaos generators, the bit-error-rate under additive white Gaussian noise is studied by computer simulations.
Method for measuring the refractive index and the thickness of transparent plates with a lateral-shear, wavelength-scanning interferometer (2003)

A new method for measuring simultaneously the thickness and the refractive index of a transparent plate is proposed. The method is based on a simple, variable lateral-shear, wavelength-scanning interferometer. To achieve highly accurate measurements of both refractive index n and thickness d we use several means to determine these two quantities. We finely tune a distributed-feedback diode laser light source to introduce a phase shift into the detected signal, whereas we make the sample rotate to produce variable lateral shearing. Phase shifting permits precise determination of the optical thickness, nd, whereas refractive index n is obtained from the retrieved phase of the overall interference signal for all incidence angles.
Nonparametric Generic Substrate ICC Profile (2008)

Digital printing has begun to play a more significant role in the current commercial printing market, and the demand for accurate color reproduction has also increased. Nonetheless, achieving wide selection of printable substrates imposes a limiting factor on color accuracy for a printing press manufacturer. The compromised solution is to only provide and maintain certain generic substrate ICC profiles based on the physical features of substrates. The main concern for this approach is that it is very difficult to establish a correlation between each substrate characteristics and the chosen imaging process. We propose a nonparametric approach by first sifting through a representative set of substrate-specific ICC profiles. Design a feature dimension reduction algorithm based on the independent component analysis, and we will be able to identify a small set of substrates achieving the optimal generic ICC profile performance against investigated substrates. At last, we will identify the important physical characteristics of a substrate affecting the performance of the ICC profile with respect to the selected imaging process.
Noise insensitive high resolution color interpolation scheme considering cross-channel correlation (2005)

The problem of recovering full-color images from a noisy and color-sampled observation is considered. The noise in imaging sensors corrupts the color filter array (CFA) and introduces artifacts during the color interpolation step. Instead of filtering the noise before or after the color interpolation step, we remove the noise during the color interpolation step. This allows us to obtain a color interpolated image without noise and artifacts, especially along the edges and in the detail of the image. Color interpolation is carried out on the weighted color difference domain to consider cross-channel correlation. To avoid artifacts in high frequency regions and improve the performance, an edge indicator function is used and directions of edges are considered in the proposed interpolation method, while noise is simultaneously removed by adaptive noise filtering. As postprocessing, modified filtering on the color difference domain is adopted to improve the quality of the image. Experimental results illustrate the benefits of the proposed method. When compared to conventional methods, the proposed method outperforms them on quantitative and qualitative criteria.
Performance enhancement of a spline-based method for extreme compression of weather radar reflectivity data (2006)

Enhancements are carried out to a contour-based method for extreme compression of weather radar reflectivity data for efficient storage and transmission over low-bandwidth data links. In particular, a new method of systematically adjusting the control points to obtain better reconstruction of the contours using B-spline interpolation is presented. Further, bit-level manipulations to achieve higher compression ratios are investigated. The efficacy of these enhancements is quantitatively evaluated with respect to achievable compression ratios and the root-mean-square error of the retrieved contours, and qualitatively assessed from the visual fidelity of the reconstructed contours. Results are presented for actual Doppler weather radar data sets
Structure and Genetic Variation of Cranberry Proanthocyanidins That Inhibit Adherence of Uropathogenic P-Fimbriated <i>E. coli</i> (2003)

Fruit of the American cranberry (Vaccinium macrocarpon Ait.) has long been considered to be beneficial for urinary tract health, and many considered the mechanism of action to be the acidification of urine due to the significant levels of benzoic acid found in the fruit. Morerecent studies found cranberry juice to have anti-adherence bioactivity against uropathogenic P-fimbriated E. coli., suggesting an alternative mechanism. Proanthocyanidins with A-type linkage were identified to be the component in cranberry fruit responsible for inhibiting adhesion of P fimbriated E. coli to cellular surfaces having disaccharide α-Gal(l→4)β-Gal receptor sequences. Bioactivity was associated with proanthocyanidin polymers, mostly consisting of epicatechin units, having DP 3 to 5 with at least one A-type linkage. Both environmental and genetic variation is observed for overall proanthocyanidin levels in cranberry fruit. Fruit proanthocyanidin levels in cranberry germplasm (collection of domesticated and undomesticated varieties) varied 6-fold. Although significant environmental, e.g. year-to-year, effects are observed, heritability estimates for cranberry fruit proanthocyanidin levels are moderate (h2 = 0.43), suggesting additive genetic variance exists, and genetic gain for enhanced proanthocyanidin levels is possible.
Combination Immunotherapy for Tumors via Sequential Intratumoral Injections of Oncolytic Herpes Simplex Virus 1 and Immature Dendritic Cells (2008)

Combination treatment of murine tumors with oHSV and iDCs reduces the volume of established tumors and prolongs survival via enhancement of antitumor immunity.
Sinusoidally phase-modulated interference microscope for high-speed high-resolution topographic imagery (2001)

We describe an interference microscope that produces topographic images with a minimum acquisition time of 20 ms. The system is based on phase-shifting interferometry with sinusoidal phase modulation induced by the oscillation of an interferometric objective (Michelson or Mirau). A CCD camera captures four images per oscillation period to produce a phase map in real time. The system is installed on a commercial microscope.
Glucose-Responsive Microneedle Patches for Diabetes Treatment (2018)

Antidiabetic therapeutics, including insulin as well as glucagon-like peptide 1 (GLP-1) and its analogs, are essential for people with diabetes to regulate their blood glucose levels. Nevertheless, conventional treatments based on hypodermic administration is commonly associated with poor blood glucose control, a lack of patient compliance, and a high risk of hypoglycemia. Closed-loop drug delivery strategies, also known as self-regulated administration, which can intelligently govern the drug release kinetics in response to the fluctuation in blood glucose levels, show tremendous promise in diabetes therapy. In the meantime, the advances in the development and use of microneedle (MN)-array patches for transdermal drug delivery offer an alternative method to conventional hypodermic administration. Hence, glucose-responsive MN-array patches for the treatment of diabetes have attracted increasing attentions in recent years. This review summarizes recent advances in glucose-responsive MN-array patch systems. Their opportunities and challenges for clinical translation are also discussed.
pH Induced Aggregation and Weak Gel Formation of Whey Protein Polymers (2000)

ABSTRACT: Whey protein polymers were formed by heating (80 °C) a 4% (w/v) whey protein (WP) isolate dispersion at pH 8.0 for 15, 25, 35, 45, or 53 min. Dispersions were adjusted to pH 6.0, 6.5, 7.0, 7.5, or 8.0 after heating and the rheological properties were determined. Viscosity increased with increased heating time and decreased pH. At pH 7.0 and 7.5, high‐viscosity dispersions with pseudoplastic and thixotropic flow behavior were formed, while weak gels were formed at pH 6.0 and 6.5. The storage (elastic) and loss (viscous) moduli of pH‐induced gels increased when temperature was increased from 7 °C to 25 °C, suggesting that hydrophobic forces are responsible for gelation. Key Words: weak‐gels, whey proteins, polymers, gelation, functionality
Automatic Feature Extraction from Planetary Images (2010)

With the launch of several planetary missions in the last decade, a large amount of planetary images has already been acquired and much more will be available for analysis in the coming years. The image data need to be analyzed, preferably by automatic processing techniques because of the huge amount of data. Although many automatic feature extraction methods have been proposed and utilized for Earth remote sensing images, these methods are not always applicable to planetary data that often present low contrast and uneven illumination characteristics. Different methods have already been presented for crater extraction from planetary images, but the detection of other types of planetary features has not been addressed yet. Here, we propose a new unsupervised method for the extraction of different features from the surface of the analyzed planet, based on the combination of several image processing techniques, including a watershed segmentation and the generalized Hough Transform. The method has many applications, among which image registration and can be applied to arbitrary planetary images.
Detection of<i>Bifidobacterium</i>Strains that Induce Large Quantities of IgA (1992)

An in vitro screening test using the murine Peyer's patch cell culture method was developed for detection of bifidobacteria which induce large quantities of IgA. Bifidobacteria grown for 48 h were added at a dose corresponding to an absorbance value of 0.275 at 660 nm to BALB/c mouse Peyer's patch cells, and 7 days later the quantities of IgA antibody in the culture supernatants were measured by an ELISA method. With this screening test, three strains of bifidobacteria capable of inducing large quantities of IgA were selected from 120 strains isolated from human faeces and identified as Bifidobacterium breve (two strains) and B. longum (one strain). When one of the three strains ( B. breve YIT 4064) was administered orally along with cholera toxin (CT) into mice, the amount of anti-CT IgA antibody in faeces and anti-CT IgA antibody production and proliferation in Peyer's patch cells tended to be greater and were significantly greater, respectively, than after administration of only CT or CT and B. breve Ka-6, which did not induce IgA. Keywords: Bifidobacterium ; Andjuvant activity; Peyer's patch; IgA; Cholera toxin.