gebhart/patrepeval huggingface dataset:
Network Intrusion Detection And Countermeasure Selection In Virtual Network (NIDCS) (2016)

Intrusion in a network or a system is a problem today as the trend of successful network attacks continue to rise. Intruders can explore vulnerabilities of a network system to gain access in order to deploy some virus or malware such as Denial of Service (DOS) attack. In this work, a frequency-based Intrusion Detection System (IDS) is proposed to detect DOS attack. The frequency data is extracted from the time-series data created by the traffic flow using Discrete Fourier Transform (DFT). An algorithm is developed for anomaly-based intrusion detection with fewer false alarms which further detect known and unknown attack signature in a network. The frequency of the traffic data of the virus or malware would be inconsistent with the frequency of the legitimate traffic data. A Centralized Traffic Analyzer Intrusion Detection System called CTA-IDS is introduced to further detect inside attackers in a network. The strategy is effective in detecting abnormal content in the traffic data during information passing from one node to another and also detects known attack signature and unknown attack. This approach is tested by running the artificial network intrusion data in simulated networks using the Network Simulator2 (NS2) software.
Spontaneous Type 2 Diabetic Rodent Models (2013)

Diabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress of T2DM and find effective treatments for its complications. On the basis of their strains, features, advantages, and disadvantages, various types of animal models of T2DM can be divided into spontaneously diabetic models, artificially induced diabetic models, and transgenic/knockout diabetic models. Among these models, the spontaneous rodent models are used more frequently because many of them can closely describe the characteristic features of T2DM, especially obesity and insulin resistance. In this paper, we aim to investigate the current available spontaneous rodent models for T2DM with regard to their characteristic features, advantages, and disadvantages, and especially to describe appropriate selection and usefulness of different spontaneous rodent models in testing of various new antidiabetic drugs for the treatment of type 2 diabetes.
Sonographic Pearls for Imaging the Brachial Plexus and Its Pathologies (2020)

The brachial plexus (BP) is a complicated neural network, which may be affected by trauma, irradiation, neoplasm, infection, and autoimmune inflammatory diseases. Magnetic Resonance Imaging is the preferred diagnostic modality; however, it has the limitations of high cost and lack of portability. High-resolution ultrasound has recently emerged as an unparalleled diagnostic tool for diagnosing postganglionic lesions of the BP. Existing literature describes the technical skills needed for prompt ultrasound imaging and guided injections for the BP. However, it remains particularly challenging for beginners to navigate easily while scanning its different parts. To address this, we share several "clinical pearls" for the sonographic examination of the BP as well as its common pathologies.
Automatic detection algorithm for physiologic pressure signal components (2003)

Describes an offline detection algorithm for pressure signals that incorporates heart rate, amplitude, and interbeat intervals to identify the time location of four signal components. The algorithm performance was assessed based on the statistics of the interbeat intervals of the detected components. The algorithm performed well when applied to arterial blood pressure and intracranial pressure signals acquired from patients in a pediatric intensive care unit.
Designing of the fixed-dose gastroretentive bilayer tablet for sustained release of metformin and immediate release of atorvastatin (2015)

Patients with type 2 diabetes mellitus have a high risk of cardiovascular disease mainly caused by dyslipidemia. Metformin and atorvastatin are preferentially used to treat type 2 diabetes mellitus and dyslipidemia, respectively. The aim of this study was to develop a once-a-day fixed-dose combination tablet containing metformin and atorvastatin. For this purpose, we designed gastroretentive bilayer tablets consisting of 500 mg metformin in a sustained release layer and 10 mg atorvastatin in an immediate release layer. In addition, we modified the formulation to maintain a dual release pattern for the kinetically different layers for once-daily dosing. The gastroretentive bilayer tablet was developed using polyethylene oxide as a swellable polymer and ammonium methacrylate copolymer as a granule-coating polymer with minimal use of excipients. In vitro release patterns of metformin and atorvastatin from the developed formulation were similar to those of the reference drugs, Glucophage XR for metformin and Lipitor for atorvastatin, with satisfactory dissolution similarity factor (f2) values. The pharmacokinetic study showed the sustained and immediate absorptions of metformin and atorvastatin, respectively, in beagle dogs. The 90% confidence intervals of the ratios of ln values of AUCs of test formulation F3 and respective reference formulations of metformin and atorvastatin were 0.93-1.12 and 0.89-1.17, respectively, compared with their respective reference drugs. This formulation could contribute to improving the compliance and therapeutic outcome of patients with metabolic diseases.
Pharmacodynamics of Mycophenolic Acid in CD4+ Cells: A Single-Dose Study of IMPDH and Purine Nucleotide Responses in Healthy Individuals (2008)

Mycophenolate mofetil is used in rejection prophylaxis after allograft transplantation. The highly variable pharmacokinetics and pharmacodynamics (PD) of the active moiety mycophenolic acid (MPA) render this drug attractive for therapeutic monitoring. The aim of this study was to characterize the exposure-response relationship for MPA to guide future strategies for individualized therapy based on PD monitoring. A single-dose (100, 250, 500, and 1000 mg mycophenolate mofetil) crossover exposure-response study of MPA PD in CD4 cells was performed in 5 healthy individuals. The activity of inosine 5'-monophosphate dehydrogenase (IMPDH) at time 0 ranged from 1.2 to 7.2 pmol per 10 cells/min. IMPDH was strongly inhibited by MPA; MPA EC50 (concentration required for 50% inhibition) of 2.3 mg/L was determined by a pooled data analysis. Decreased IMPDH gene expression was associated with the exposure to MPA. There were no immediate reductions of guanine nucleotides. On the contrary, a trend toward increased guanosine triphosphate was observed. IMPDH activity AUC0-12h approached maximum reduction at MPA AUC0-12h 22 mg x h/L (corresponding to the 500 mg dose), whereas plasma concentrations exceeding approximately 6 mg/L did not further increase the IMPDH inhibition. The results suggest that guanine nucleotides in circulating lymphocytes may not serve as immediate response biomarkers to MPA. Strategies for preventing over- or underexposure to MPA may be developed by means of IMPDH activity combined with MPA concentration measurement.
Detection of Optic Disc in Retinal Images by Means of a Geometrical Model of Vessel Structure (2004)

We present here a new method to identify the position of the optic disc (OD) in retinal fundus images. The method is based on the preliminary detection of the main retinal vessels. All retinal vessels originate from the OD and their path follows a similar directional pattern (parabolic course) in all images. To describe the general direction of retinal vessels at any given position in the image, a geometrical parametric model was proposed, where two of the model parameters are the coordinates of the OD center. Using as experimental data samples of vessel centerline points and corresponding vessel directions, provided by any vessel identification procedure, model parameters were identified by means of a simulated annealing optimization technique. These estimated values provide the coordinates of the center of OD. A Matlab prototype implementing this method was developed. An evaluation of the proposed procedure was performed using the set of 81 images from the STARE project, containing images from both normal and pathological subjects. The OD position was correctly identified in 79 out of 81 images (98%), even in rather difficult pathological situations.
Plasma‐Assisted Atomic Layer Deposition of Al<sub>2</sub>O<sub>3</sub> at Room Temperature (2009)

Abstract A new design of plasma source has been used for the plasma‐assisted atomic layer deposition (PA‐ALD) of Al 2 O 3 films at room temperature. In this PA‐ALD reactor the plasma is generated by capacitive coupling directly in the deposition chamber adjacent to the substrate but can be separated from it by a grid to reduce the ion bombardment while maintaining the flow of radicals directly to the substrate surface. During the ALD cycle a mixture of nitrogen and argon was introduced into the reactor to act as a purge gas between precursor pulses and to facilitate the generation of a plasma during the plasma cycle. Sequential exposures of TMA and excited O 2 precursors were used to deposit Al 2 O 3 films on Si(100) substrates. A plasma discharge was activated during the oxygen gas pulse to form radicals in the reactor space. The experiments showed that the growth rate of the film increased with increasing plasma power and with increasing O 2 pulse length before saturating at higher power and longer O 2 pulse length. The growth rate saturated at the level of 1.78 Å·cycle −1 . EDS analysis showed that the films were oxygen rich and had carbon as an impurity. This can be explained by the presence of bonds between hydrocarbons from the unreacted TMA precursor and excess oxygen in the film. ATR‐FTIR spectroscopy measurements indicated a change in growth mechanism when the distance between the location of the radical generation and the substrate was varied. A similar effect was observed with the use of different plasma power levels.
REQUEST ANALYSIS OF DGPS/IMU ON THE AIR-BORNE INSAR SYSTEM (2012)

Abstract. The DGPS/IMU can measure position and velocity extremely high, and it is widely used in air-borne InSAR system. The passage based on the DGPS/IMU's action in the airborne InSAR system, makes sure the interference phase accuracy, from the analysis of the interference phase accuracy influence by InSAR imaging motivation compensation makes sure the interference phase accuracy, and analyzes the system's request of DGPS/IMU from the DEM accuracy's influence by DGPS/IMU's surveying error. At last the paper advances the accuracy request of the DGPS/IMU system, and provides basis for the InSAR system's selection of DGPS/IMU system.
Theoretical study of subwavelength imaging by acoustic metamaterial slabs (2009)

We investigate theoretically subwavelength imaging by acoustic metamaterial slabs immersed in the liquid matrix. A near-field subwavelength image formed by evanescent waves is achieved by a designed metamaterial slab with negative mass density and positive modulus. A subwavelength real image is achieved by a designed metamaterial slab with simultaneously negative mass density and modulus. These results are expected to shed some light on designing novel devices of acoustic metamaterials.
Design verification using formal techniques (2002)

Functional verification is often the bottleneck in a hardware design flow. While simulation and coverage analysis still represent the main stream verification methodology, formal verification shows a lot of promise in its ability to exhaustively search the design space. This tutorial introduces some basic concepts for applying formal verification and presents a methodology that combines formal techniques and simulation. We use a concrete hardware design (UART) as an illustration throughout our discussion.
Muscle Stem Cells and Exercise Training (2005)

Adult skeletal muscle fibers are terminally differentiated such that hypertrophy and regeneration require resident stem cell populations. This review examines the current understanding of the factors regulating muscle stem cells in response to exercise and identify the role of these cells in the adaptive response of skeletal muscle to endurance and resistance exercise training.
The C‐terminal domain of plant catalases Implications for a glyoxysomal targeting sequence (1991)

A castor bean (Ricinus communis cv. Hale) cDNA encoding catalase was cloned and sequenced. The cDNA encoding the carboxy-terminal domain of catalase was compared to the corresponding sequences of six other plant catalases. The deduced amino acid sequences were compared according to the chemical attributes of each amino acid within each carboxy-terminal domain. A tripeptide sequence having the chemical attributes of the peroxisomal targeting sequence [Gould, S.J., Keller, G.-A., Hosken, N., Wilkinson, J. & Subramani, S. (1989) J. Cell Biol. 108, 1657-1664] was common to all the glyoxysomal/peroxisomal plant catalases. This sequence motif was located six amino acids from the carboxy terminus of each of the plant catalases. An identical motif was also found within the carboxy-terminal domain of three mammalian catalases previously sequenced. We hypothesize that these motifs are at least part of the targeting mechanism for catalase entry into plant glyoxysomes/peroxisomes.
Maximal Wind Energy Tracing of Brushless Doubly-Fed Generator under Flux Oriented Vector Control (2012)

The aim of this paper is to present the complete modeling and simulation of a grid-connected brushless doubly fed induction generator (BDFG) for variable wind energy conversion is used to assess a maximum power point tracking MPPT strategy for different velocities. The decoupling control of active and reactive powers for BDFG has been developed using PI controllers. The performance of proposed stator power winding flux oriented vector control is examined. The complete system is simulated in the Matlab/Simulink environment and the computer simulation results obtained confirm the effectiveness and validity of MPPT strategy.
Variable latent semantic indexing (2005)

Latent Semantic Indexing is a classical method to produce optimal low-rank approximations of a term-document matrix. However, in the context of a particular query distribution, the approximation thus produced need not be optimal. We propose VLSI, a new query-dependent (or "variable") low-rank approximation that minimizes approximation error for any specified query distribution. With this tool, it is possible to tailor the LSI technique to particular settings, often resulting in vastly improved approximations at much lower dimensionality. We validate this method via a series of experiments on classical corpora, showing that VLSI typically performs similarly to LSI with an order of magnitude fewer dimensions.
Towards Identifying Factors Underlying Readiness for Online Learning: An Exploratory Study (2003)

To test the potential value of McVay's (2000) Readiness for Online Learning questionnaire for research and practice, the instrument was administered to 107 undergraduate university students drawn from a range of courses in the United States and Australia. The questionnaire was subjected to a reliability analysis and a factor analysis. The instrument fared well in the reliability analysis, and yielded a two-factor structure that was readily interpretable in a framework of existing theory and research. Factors identified were "Comfort with e-learning" and "Self-management of learning." It is suggested that the instrument is useful for both research and practice, but would be enhanced through further work on 5 of the 13 items. Additionally, further work is required to establish predictive validity.
Effect of spermidine on the <i>in vivo</i> degradation of ornithine decarboxylase in <i>Saccharomyces cerevisiae</i> (2001)

As part of our studies on the regulation of polyamine biosynthesis in Saccharomyces cerevisiae, we have investigated the effect of spermidine on the degradation of ornithine decarboxylase in this organism. We have found that in S. cerevisiae, as in other eukaryotic cells, the rate of degradation of ornithine decarboxylase, measured either enzymatically or immunologically, is increased by the addition of spermidine to a yeast culture. It is noteworthy that this effect of added spermidine is found even when the experiments are conducted with strains in which the ornithine decarboxylase is overexpressed several hundred-fold more than the wild-type level. The effect of added spermidine in the overexpressed SPE1 strains is best seen in spe2 mutants in which the initial intracellular spermidine is very low or absent. Experiments with cycloheximide show that new protein synthesis is required to effect the breakdown of the ornithine decarboxylase. These results indicate that S. cerevisiae contains an antizyme-like mechanism for the control of the level of ornithine decarboxylase by spermidine, even though, as contrasted with other eukaryotic cells, no specific antizyme homologue has been detected either in in vitro experiments or in the S. cerevisiae genome.
A convenient synthesis of N-benzyloxy-.BETA.-lactams via N-benzyloxyimines. (1989)

N-Benzyloxy-β-lactams were prepared from N-benzyloxyimines by reaction with ketene trimethylsilyl acetals in the presence of trimethylsilyl triflate followed by cyclization, or with lithium ester enolates in one step.
Requirements for policy languages for trust negotiation (2003)

In open systems like the Internet, traditional approaches to security based on identity do not provide a solution to the problem of establishing trust between strangers, because strangers do not share the same security domain. A new approach to establishing trust between strangers is trust negotiation, the bilateral exchange of digital credentials describing attributes of the negotiation participants. This approach relies on access control policies that govern access to protected resources by specifying credential combinations that must be submitted to obtain authorization. We describe a model for trust negotiation, focusing on the central role of policies. We delineate requirements for policy languages and runtime systems for trust negotiation, and evaluate four existing policy languages for trust management with respect to those requirements. We conclude with recommendations for extending existing policy languages or developing new policy languages to make them suitable for use in future trust negotiation systems.
Effect of the presence of initial ethanol on ethanol production in sugar cane juice fermented by Zymomonas mobilis (2003)

Ethanol production in sugar cane juice in high initial sugar concentration, fermented by Z. mobilis in the presence and absence of ethanol, was evaluated. Ethanol production was low in both media. The presence of initial ethanol in the sugar cane juice reduced ethanol production by 48.8%, biomass production by 25.0% and the total sugar consumption by 28.3%. The presence of initial ethanol in the medium did not affect significantly levan production and biomass yield coefficient (g biomass/g sugar consumed).
Microfluidic passive permeability assay using nanoliter droplet interface lipid bilayers (2013)

Membrane permeability assays play an important role in assessing drug transport activities across biological membranes. However, in conventional parallel artificial membrane permeability assays (PAMPA), the membrane model used is dissimilar to biological membranes physically and chemically. Here, we describe a microfluidic passive permeability assay using droplet interface bilayers (DIBs). In a microfluidic network, nanoliter-sized donor and acceptor aqueous droplets are alternately formed in cross-flowing oil containing phospholipids. Subsequently, selective removal of oil through hydrophobic pseudo-porous sidewalls induces the contact of the lipid monolayers, creating arrayed planar DIBs between the donor and acceptor droplets. Permeation of fluorescein from the donor to the acceptor droplets was fluorometrically measured. From the measured data and a simple diffusion model we calculated the effective permeabilities of 5.1 × 10(-6) cm s(-1), 60.0 × 10(-6) cm s(-1), and 87.6 × 10(-6) cm s(-1) with donor droplets at pH values of 7.5, 6.4 and 5.4, respectively. The intrinsic permeabilities of specific monoanionic and neutral fluorescein species were obtained similarly. We also measured the permeation of caffeine in 10 min using UV microspectroscopy, obtaining a permeability of 20.8 × 10(-6) cm s(-1). With the small solution volumes, short measurement time, and ability to measure a wide range of compounds, this device has considerable potential as a platform for high-throughput drug permeability assays.
Description of focal liver lesions with using Gd-EOB-DTPA enhanced MRI (2015)

Imaging procedures play a fundamental role in the therapeutic management of focal liver lesions. The goals of imaging are to detect and correctly characterize focal liver lesions. This review highlights the performances of newer, liver-specific, contrast media in the diagnosis of focal liver lesions, particularly Gd-EOB-DTPA (Primovist), the most frequently used liver specific contrast media. It has been shown, in different papers, that Gd-EOB-DTPA has better performances compared to either triphasic contrast enhanced computed tomography or dynamic MRI in both detection and characterization of hepatocellular carcinoma on the cirrhotic liver. Therefore liver MRI with Primovist is considered, in many centers, the "state-of-the-art" imaging examination of the liver before surgery or liver transplantation. Gd-EOB-DTPA is also useful in the differential diagnosis of benign hypervascular focal liver lesions such as adenomas or focal nodular hyperplasias.
Chitosan microspheres containing Bordetella bronchiseptica antigens as novel vaccine against atrophic rhinitis in pigs. (2008)

The immune-stimulating activities of Bordetella bronchiseptica antigens containing dermonecrotoxin (BBD) loaded in chitosan microspheres (CMs) have already been reported in vitro and in vivo with a mouse alveolar macrophage cell line (RAW264.7) and mice. Therefore, this study attempted to demonstrate the successful induction of mucosal immune responses after the intranasal administration of BBD loaded in CMs (BBD-CMs) in colostrum-deprived pigs. The BBD was introduced to the CMs using an ionic gelation process involving tripolyphosphate (TPP). Colostrum-deprived pigs were then directly immunized through intranasal administration of the BBD-CMs. A challenge with a field isolate of B. bronchiseptica was performed ten days following the final immunization. The BBD-specific IgG and IgA titers, evident in the nasal wash and serum from the vaccinated pigs, increased with time (p<0.05). Following the challenge, the clinical signs of infection were about 6-fold lower in the vaccinated pigs compared with the nonvaccinated pigs. The grades for gross morphological changes in the turbinate bones from the vaccinated pigs were also significantly lower than the grades recorded for the nonvaccinated pigs (p<0.001). Therefore, the mucosal and systemic immune responses induced in the current study would seem to indicate that the intranasal administration of BBD-CMs may be an effective vaccine against atrophic rhinitis in pigs.