gebhart/patrepeval huggingface dataset:
Probability-Based Address Translationfor Flash SSDs (2020)

Thanks to the advance of NAND scaling technologies, an ultra-scale SSD (e.g., <inline-formula><tex-math notation="LaTeX">$>$</tex-math></inline-formula> 100 TB) is introduced to markets. This rapid increase of SSD capacity, however, comes at the cost of more DRAM which resides in an SSD controller for logical-to-physical (L2P) address translation. Many have proposed various address translation algorithms to reduce DRAM, but they fail to provide short read latency, in particular when a workload has weak locality. This letter proposes a novel probability-based address translation algorithm, called <i>ProbFTL</i> . In contrast to existing translation techniques that maintain exact L2P mapping, ProbFTL employs a probability-based data structure, a bloom filter, for address translation. By leveraging a space-efficient nature of a bloom filter, ProbFTL reduces the amount of DRAM for address translation to 20 percent of the existing techniques. The read latency of ProbFTL is not affected from locality of a workload; ProbFTL guarantees a read amplification factor of 1.1 even under a random read workload. ProbFTL exhibits slightly worse garbage collection efficiency, but its write amplification factor is maintained sufficiently low.
Nontransgenic Marker-Free Gene Disruption by an Episomal CRISPR System in the Oleaginous Microalga, <i>Nannochloropsis oceanica</i> CCMP1779 (2018)

Utilization of microalgae has been hampered by limited tools for creating loss-of-function mutants. Furthermore, modified strains for deployment into the field must be free of antibiotic resistance genes and face fewer regulatory hurdles if they are transgene free. The oleaginous microalga, Nannochloropsis oceanica CCMP1779, is an emerging model for microalgal lipid metabolism. We present a one-vector episomal CRISPR/Cas9 system for N. oceanica that enables the generation of marker-free mutant lines. The CEN/ARS6 region from Saccharomyces cerevisiae was included in the vector to facilitate its maintenance as circular extrachromosal DNA. The vector utilizes a bidirectional promoter to produce both Cas9 and a ribozyme flanked sgRNA. This system efficiently generates targeted mutations, and allows the loss of episomal DNA after the removal of selection pressure, resulting in marker-free non-transgenic engineered lines. To test this system, we disrupted the nitrate reductase gene (NR) and subsequently removed the CRISPR episome to generate non-transgenic marker-free nitrate reductase knockout lines (NR-KO).
A laser scanning camera for range data acquisition (1988)

Describes a high-speed scanning triangulation system which captures and displays range data and which operates over a wide field of view. This is facilitated by reflecting both a projected stripe and an offset imaging path from the same scanning mirror so that the stripe image position is directly related to range. Electronic hardware enables the stripe image to be analysed in real time. Three-dimensional measurement is then achieved by mechanical scanning which moves the light stripe across the scene. The use of the system to produce dense range data is described. Some limitations of system performance are discussed.
Ein neues Zielgerät und zwei neue Kreuzbandanker zur Befestigung von prothetischem Kreuzbandersatz am Femur - A New Drilling Device and New Anchors for the Fixation of Prosthetic Cruciate Ligaments to the Femur (1991)

Article Ein neues Zielgerät und zwei neue Kreuzbandanker zur Befestigung von prothetischem Kreuzbandersatz am Femur - A New Drilling Device and New Anchors for the Fixation of Prosthetic Cruciate Ligaments to the Femur was published on January 1, 1991 in the journal Biomedical Engineering / Biomedizinische Technik (volume 36, issue 1-2).
Immunomodulatory effects of OX40Ig gene-modified adipose tissue-derived mesenchymal stem cells on rat kidney transplantation (2016)

Recent studies have suggested that adipose tissue-derived mesenchymal stem cell (ADSC) therapy and OX40 costimulation blockade are two immunomodulatory strategies used to suppress the immune response to alloantigens. However, relatively little has been reported regarding the immunomodulatory potential of the abilityof these two strategies to synergize. Thus, in the present study, we aimed to investigate OX40-Ig fusion protein (OX40Ig) expression in ADSCs and to validate their more potent immunosuppressive activity in preventing renal allograft rejection. For this purpose, ADSCs from Lewis rats were transfected with the recombinant plasmid, pcDNA3.1(-)OX40Ig, by nucleofection. The ADSCs transduced with the plasmid (termed ADSCsOX40Ig) or untransduced ADSCs (termed ADSCsnative) were added to allostimulated mixed lymphocyte reaction (MLR) in vitro. In vivo, ADSCsOX40Ig, ADSCsnative, or PBS were administered to an allogeneic renal transplantation model, and the therapeutic effects, as well as the underlying mechanisms were examined. The results revealed that both the ADSCsnative and ADSCsOX40Ig significantly suppressed T cell proliferation and increased the percentage of CD4+CD25+ regulatory T cells in allogeneic MLR assays, with the ADSCsOX40Ig being more effective. Furthermore, the results from our in vivo experiments revealed that compared with the ADSCsnative or PBS group, the administration of autologous ADSCsOX40Ig markedly prolonged the mean survival time of renal grafts, reduced allograft rejection, and significantly downregulated the mRNA expression of intragraft interferon-γ (IFN-γ) , and upregulated the mRNA expression of interleukin (IL)‑10, transforming growth factor-β (TGF-β) and forkhead box protein 3 (Foxp3). The findings of our study indicate that the use of ADSCsOX40Ig is a promising strategy for preventing renal allograft rejection. This strategy provides the synergistic benefits of ADSC immune modulation and OX40-OX40L pathway blockade, and may therefore have therapeutic potential in clinical renal transplantation.
Osteomyelitis of the diabetic foot: MR imaging-pathologic correlation. (1997)

Marrow edema cannot be reliably distinguished from osteomyelitis with MR imaging. Gadopentetate dimeglumine is of limited use. Some previously published false-positive reports of osteomyelitis were most likely due to edema of the marrow. MR imaging is useful in planning surgery of the infected diabetic foot, as it enables reliable distinction between normal and abnormal areas.
Response initiated multiple access (RIMA), a medium access control protocol for satellite channels (2002)

The means of achieving full duplex broadband access to either the home or office has been the focus of much research and entrepreneurial development in the past 5 years. This is the so-called "last mile" problem. One approach is duplex access to either a geostationary Earth orbit (GEO) or non-GSO satellite, through a relatively small satellite dish located at each home or office. This scenario gives rise to a multiple access problem in the uplink (i.e. terrestrial Earth terminal to satellite) channel. We present response initiated multiple access, RIMA, a medium access protocol which seeks to maximize the uplink system capacity while providing a suitable quality of service (QoS) for those terrestrial users accessing the satellite system. We assume an underlying TDMA physical layer and present simulation results which detail the performance of RIMA an environment where the dominant source of user traffic comes from the Hyper Text Transfer Protocol.
Gene therapy for obesity (2005)

A sedentary life-style and an environment of caloric abundance have contributed to the recent rise in the incidence of obesity. Treating such a complex disease requires an understanding of its underlying molecular mechanisms that has only recently become possible with the sequencing of the human genome and the mapping of hundreds of genes associated with increased risk of obesity. With few safe and efficacious weight-maintenance drugs available on the market, gene therapy offers an alternative long-term treatment modality. Still in its infancy, gene therapy for obesity is poised for significant progress, due in large part to a wide variety of available gene targets and the development of novel systems to control gene expression. Coincidently, novel vectors are being developed based on adeno-associated virus providing efficient and sustained expression of a transgene in metabolically important tissues. These advances are driving the development of gene therapy as a viable therapeutic option in treating obesity and its associated disorders.
Human Mesenchymal Stromal Cells Regulate Initial Self-Renewing Divisions of Hematopoietic Progenitor Cells by a β1-Integrin-Dependent Mechanism (2006)

In previous reports, we have demonstrated that only direct cell-cell contact with stromal cells, such as the murine stromal cell line AFT024, was able to alter the cell division kinetics and self-renewing capacity of hematopoietic progenitor cells (HPC). Because beta(1)-integrins were shown to be crucial for the interaction of HPC with the bone marrow microenvironment, we have studied the role of beta(1)-integrins in the regulation of self-renewing cell divisions. For this purpose, we used primary human mesenchymal stromal (MS) cells as in vitro surrogate niche and monitored the division history and subsequent functional fate of individually plated CD34(+)133(+) cells in the absence or presence of an anti-beta(1)-integrin blocking antibody by time-lapse microscopy and subsequent long-term culture-initiating cell (LTC-IC) assays. beta(1)-Integrin-mediated contact with MS cells significantly increased the proportion of asymmetrically dividing cells and led to a substantial increase of LTC-IC. Provided that beta(1)-integrin-mediated contact was available within the first 72 hours, human MS cells were able to recruit HPC into cell cycle and accelerate their division kinetics without loss of stem cell function. Activation of beta(1)-integrins by ligands alone (e.g., fibronectin and vascular cell adhesion molecule-1) was not sufficient to alter the cell division symmetry and promote self-renewal of HPC, thus indicating an indirect effect. These results have provided evidence that primary human MS cells are able to induce self-renewing divisions of HPC by a beta(1)-integrin-dependent mechanism.
Optimization and Initial Evaluation of 1,2-Indandione as a Reagent for Fingerprint Detection (2003)

1,2-Indandione has been used to develop fluorescent fingerprints on porous materials such as paper. The compound reacts with amino acid residues to produce highly fluorescent fingerprint ridges. An optimized formulation and treatment protocol for using the reagent is presented here. The reagent is applied as a solution in HFE7100 containing acetic acid and ethyl acetate. Treated articles are heated at 100 degrees C for 10 min at ambient humidity and stored in the dark before recording the fingerprints using fluorescence photography or digital imaging. Photodecomposition of the fluorescent fingerprints has been observed. Storage in the dark reduces degradation, extending the lifetime of the fingerprints. Other chemical methods to stabilize the fingerprints proved unsuccessful. Comparisons of the performance of 1,2-indandione with DFO in CFC113 performed on a limited range of substrates indicated that the reagent might be an effective method for the development of latent fingerprints despite the new reagent producing less intense fluorescence.
Orthogonalized Equity Risk Premia and Systematic Risk Decomposition (2010)

To solve the dependency problem between factors, in the context of linear multi-factor models, this study proposes an optimal procedure to find orthogonalized risk premia, which also facilitates the decomposition of the coefficient of determination. Importantly, the new risk premia may diverge significantly from the original ones. The decomposition of risk allows one to explicitly examine the impact of individual factors on the return variation of risky assets, which provides discriminative power for factor selection. The procedure is experimentally robust even for small samples. Empirically we find that even though on average, approximately eighty (sixtyfive) percent of style (industry) portfolios’ volatility is explained by the market and size factors, other factors such as value, momentum and contrarian still play an important role for certain portfolios. The components of systematic risk, while dynamic over time, generally exhibit negative correlation between market, on one side, and size, value, momentum and contrarian, on the other side.
Gosteli−Claisen Rearrangement: Substrate Synthesis, Simple Diastereoselectivity, and Kinetic Studies (2009)

The results of kinetic studies on the uncatalyzed [3,3]-sigmatropic rearrangement of 2-alkoxycarbonyl-substituted allyl vinyl ethers are reported. Apparently first reported by Gosteli in 1972, this variation of a Claisen rearrangement enjoyed a shadowy existence for three decades until its potential for the development of a catalytic asymmetric Claisen rearrangement was discovered. Inspired by this development, we have studied substituent and solvent rate effects, and we provide evidence that a chairlike transition state is highly favorable for the uncatalyzed Gosteli-Claisen rearrangement.
Valence focus and arousal focus: Individual differences in the structure of affective experience. (1995)

The structure of affect is well represented as a circumplex. The results of a within-subject longitudinal study of self-reported mood indicate individual differences in the circumplex structure of affective experience. These differences can be captured by two constructs: valence focus and arousal focus. Valence focus is the degree to which individuals attend the hedonic component of their affective experience; arousal focus is the degree to which individuals attend the arousal component of their affective experience. In this study, differences in individuals' attention to the hedonic and arousal components of affective experience were related to observed correlations between specific affective elements, such as ( a) ratings of anxious and depressed mood and (b)Negative Affect and Positive Affect.
Characterization of a Ho^3+-doped fluoride fiber laser with a 39-μm emission wavelength (1997)

The fluoride fiber laser with the longest emission wavelength, the Ho(3+)-transition at 3.9 mum in the attenuation minimum of the 3-5-mum atmospheric window, is characterized. After reviewing the importance of fluoride fibers due to their low phonon energies, we describe room-temperature fluorescence and laser action with liquid-nitrogen cooling. Continuous-wave laser action at 3.9 mum is presented for the 640- and the 890-nm pump ranges. A shift of the emission wavelength is achieved by varying the resonator mirrors. Laser characteristics and temperature dependence are discussed.
Adrenergic nerves activate an angio-metabolic switch in prostate cancer (2017)

Nerves closely associate with blood vessels and help to pattern the vasculature during development. Recent work suggests that newly formed nerve fibers may regulate the tumor microenvironment, but their exact functions are unclear. Studying mouse models of prostate cancer, we show that endothelial β-adrenergic receptor signaling via adrenergic nerve-derived noradrenaline in the prostate stroma is critical for activation of an angiogenic switch that fuels exponential tumor growth. Mechanistically, this occurs through alteration of endothelial cell metabolism. Endothelial cells typically rely on aerobic glycolysis for angiogenesis. We found that the loss of endothelial <i>Adrb2</i>, the gene encoding the β<sub>2</sub>-adrenergic receptor, leads to inhibition of angiogenesis through enhancement of endothelial oxidative phosphorylation. Codeletion of <i>Adrb2</i> and <i>Cox10</i>, a gene encoding a cytochrome IV oxidase assembly factor, prevented the metabolic shift induced by <i>Adrb2</i> deletion and rescued prostate cancer progression. This cross-talk between nerves and endothelial metabolism could potentially be targeted as an anticancer therapy.
CellSense: An Accurate Energy-Efficient GSM Positioning System (2011)

Context-aware applications have been gaining huge interest in the last few years. With cell phones becoming ubiquitous computing devices, cell phone localization has become an important research problem. In this paper, we present CellSense, which is a probabilistic received signal strength indicator (RSSI)-based fingerprinting location determination system for Global System for Mobile Communications (GSM) phones. We discuss the challenges of implementing a probabilistic fingerprinting localization technique in GSM networks and present the details of the CellSense system and how it addresses these challenges. We then extend the proposed system using a hybrid technique that combines probabilistic and deterministic estimations to achieve both high accuracy and low computational overhead. Moreover, the accuracy of the hybrid technique is robust to changes in its parameter values. To evaluate our proposed system, we implemented CellSense on Android-based phones. Results from two different testbeds, representing urban and rural environments, for three different cellular providers show that CellSense provides at least 108.57% enhancement in accuracy in rural areas and at least 89.03% in urban areas compared with current state-of-the-art RSSI-based GSM localization systems. In additional, the proposed hybrid technique provides more than 6 and 5.4 times reduction in computational requirements compared with state-of-the-art RSSI-based GSM localization systems for rural and urban testbeds, respectively. We also evaluate the effect of changing the different system parameters on the accuracy-complexity tradeoff and how the cell tower and fingerprint densities affect system performance.
Neural Network Approaches to Dialog Response Retrieval and Generation (2016)

In this work, we propose a new statistical model for building robust dialog systems using neural networks to either retrieve or generate dialog response based on an existing data sources. In the retrieval task, we propose an approach that uses paraphrase identification during the retrieval process. This is done by employing recursive autoencoders and dynamic pooling to determine whether two sentences with arbitrary length have the same meaning. For both the generation and retrieval tasks, we propose a model using long short term memory (LSTM) neural networks that works by first using an LSTM encoder to read in the user's utterance into a continuous vector-space representation, then using an LSTM decoder to generate the most probable word sequence. An evaluation based on objective and subjective metrics shows that the new proposed approaches have the ability to deal with user inputs that are not well covered in the database compared to standard example-based dialog baselines.
Direct performance-driven placement of mismatch-sensitive analog circuits (1995)

Article Free Access Share on Direct performance-driven placement of mismatch-sensitive analog circuits Authors: K. Lampaert Katholieke Universiteit Leuven, Dep. Elektrotechniek, ESAT-MICAS, Kardinaal Mercierlaan 94, B-3001 Heverlee, Belgium Katholieke Universiteit Leuven, Dep. Elektrotechniek, ESAT-MICAS, Kardinaal Mercierlaan 94, B-3001 Heverlee, BelgiumView Profile , G. Gielen National Fund of Scientific Research and Katholieke Universiteit Leuven, Dep. Elektrotechniek, ESAT-MICAS, Kardinaal Mercierlaan 94, B-3001 Heverlee, Belgium National Fund of Scientific Research and Katholieke Universiteit Leuven, Dep. Elektrotechniek, ESAT-MICAS, Kardinaal Mercierlaan 94, B-3001 Heverlee, BelgiumView Profile , W. Sansen Katholieke Universiteit Leuven, Dep. Elektrotechniek, ESAT-MICAS, Kardinaal Mercierlaan 94, B-3001 Heverlee, Belgium Katholieke Universiteit Leuven, Dep. Elektrotechniek, ESAT-MICAS, Kardinaal Mercierlaan 94, B-3001 Heverlee, BelgiumView Profile Authors Info & Claims DAC '95: Proceedings of the 32nd annual ACM/IEEE Design Automation ConferenceJanuary 1995 Pages 445–449https://doi.org/10.1145/217474.217568Published:01 January 1995Publication History 4citation193DownloadsMetricsTotal Citations4Total Downloads193Last 12 Months12Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
High sulphidity kraft pulping (2009)

The object of this project was to evaluate the effect of high sulphidity on the performance of the kraft cooking process. Softwood (SW) mix (50/50 of spruce, Picea abies, and pine, Pinus sylvestris ...
Modulation of sexual behaviour in the rat by a potent and selective α<sub>2</sub>‐adrenoceptor antagonist, delequamine (RS‐15385‐197) (1996)

1. The contributions of alpha 2-adrenoceptors and 5-HT1A receptors to sexual behaviour in the rat have been re-evaluated by use of a highly potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197), yohimbine, idazoxan and the partial agonist at 5-HT1A receptors, 8-hydroxy-2(di-n-propylamino)-tetralin (8-OH-DPAT). 2. In a model where naive male rats were introduced to oestrogen-progesterone primed, sexually receptive female rats, delequamine (0.4-6.4 mg kg-1, p.o.) dose-relatedly increased the sexual behaviour score over the entire dose-range whereas yohimbine was effective at only one dose, 2 mg kg-1, p.o.. Idazoxan was active only at 2.5 and 5 mg kg-1, p.o. Yohimbine, but neither delequamine nor idazoxan, decreased ejaculation latency. 8-OH-DPAT (0.1 and 0.25 mg kg-1, s.c.) reduced the time, and the number of intromissions to ejaculation without affecting other parameters. A combination of delequamine (0.4 mg kg-1, p.o.) and 8-OH-DPAT (0.1 mg kg-1 s.c.) increased the percentage of rats mounting, intromitting and ejaculating, and reduced ejaculation latency and the number of intromissions. 3. In orchidectomized, sexually experienced rats exposed to sexually receptive females, delequamine, idazoxan and yohimbine increased the number of rats mounting, and there was a tendency to increase the number of animals intromitting, but no effect on ejaculatory behaviour. 4. In ovariectomized female rats brought to low level receptivity by priming with low dose injections of oestradiol benzoate and progesterone, delequamine, at 1.6 and 6.4 mg kg-1 p.o., increased lordosis, while yohimbine, at 2, 4 and 8 mg kg-1 p.o., reduced lordotic responses to sexually experienced males in a dose-dependent manner. 8-OH-DPAT at 0.1, 0.25 mg kg-1, s.c. reduced lordosis in a dose-dependent manner. 5. These findings may be explained on the basis that yohimbine is an alpha 2-adrenoceptor antagonist with affinity for 5-HT1A receptors and that the effects of 5-HT1A receptors may modulate the sexual behaviour responses to alpha 2-receptor antagonism in some models. Thus, in contrast to yohimbine, the highly-selective alpha 2-adrenoceptor antagonist, delequamine, was very effective in increasing the behavioural score in male and female rats over a wide dose-range.