gebhart/patrepeval huggingface dataset:
Synthetic Surfaces for Ribonuclease Adsorption (2004)

Intact RNA and DNA are of central importance to biochemical research and biotechnology. The preservation of these nucleic acids requires the absence of nuclease activity. Here, radical-mediated polymerization of vinylsulfonate on resin and glass surfaces is shown to produce a high-density poly(vinylsulfonate) coating that sequesters ribonucleases from aqueous solutions quickly and completely. The adsorptive efficacy of this coating exceeds that of other known coatings by > or =10(7)-fold. Surfaces coated with poly(vinylsulfonate) could be used to maintain the integrity of ribonucleic acids in a variety of contexts.
과학영재학교의 가치평가 -영재학교 대구과학고등학교의 사례를 중심으로- (2012)

본 연구는 대구과학고등학교 사례를 중심으로 과학영재학교의 가치를 측정하고자 한다. 분석방법으로서 조건부가치평가법을 적용하였다. 분석에 사용된 자료는 대구광역시 소재 일반 고등학교 학부모 280명을 대상으로 하는 설문조사를 통해 수집되었으며, 계량경제학적 추정방법으로 로짓모형의 최우추정법이 적용되었다. 분석 결과, 첫째 대구과학고등학교의 지속적인 운영과 시설보강 및 우수 인력 양성 등에 대한 응답자의 지불의사액 추정모형에서 응답자의 교육년수와 가구 소득이 통계적으로 유의미한 설명력을 갖는 것으로 나타났으며, 둘째 대구과학고등학교를 통한 과학영재 양성에 대해 가구당 연간 46,164원을 지불할 의사가 있는 것으로 나타났다.
The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors (2008)

Palmitoylethanolamide (PEA) is an endogenous lipid that is thought to be involved in endogenous protective mechanisms activated as a result of stimulation of inflammatory response. In spite of the well demonstrated anti-inflammatory properties of PEA, its involvement in controlling pain pathways still remains poorly characterized. On this basis, we tested the efficacy of PEA in vivo against a peculiar persistent pain, such as neuropathic one. PEA was administered i.p. to mice with chronic constriction injury of sciatic nerve (CCI) once a day for one week starting the day after the lesion. This therapeutic regimen evoked a relief of both thermal hyperalgesia and mechanical allodynia in neuropathic mice. Various selective receptor antagonists were used in order to clarify the relative contribution of cannabinoid, vanilloid and peroxisome proliferator-activated receptor to PEA-induced effects. The results indicated that CB(1), PPARgamma and TRPV1 receptors mediated the antinociception induced by PEA, suggesting that the most likely mechanism might be the so-called "entourage effect" due to the PEA-induced inhibition of the enzyme catalyzing the endocannabinoid anandamide (AEA) degradation that leads to an enhancement of its tissue levels thus increasing its analgesic action. In addition, the hypothesis that PEA might act through the modulation of local mast cells degranulation is sustained by our findings showing that PEA significantly reduced the production of many mediators such as TNFalpha and neurotrophic factors, like NGF. The findings presented here, in addition to prove the beneficial effects of PEA in chronic pain, identify new potential targets for analgesic medicine.
Normal Variations of Sphenoid Sinus and the Adjacent Structures Detected in Cone Beam Computed Tomography. (2016)

The anatomical variations of the sphenoid sinus tend to give rise to a complexity of symptoms and potentially serious complications. This variability necessitates a comprehensive understanding of the regional sphenoid sinus anatomy by a detailed CBCT sinus examination.
Separation of mutant and wild-type ribosomes based on differences in their anti Shine - Dalgarno sequence (1993)

We describe a system to isolate 30S ribosomal subunits which contain targeted mutations in their 16S rRNA. The mutations of interest should be present in so-called specialized 30S subunits which have an anti-Shine-Dalgarno sequence that is altered from 5' ACCUCC to 5' ACACAC. These plasmid-encoded specialized 30S subunits are separated from their chromosomally encoded wild-type counterparts by affinity chromatography that exploits the different Shine-Dalgarno complementarity. An oligonucleotide complementary to the 3' end of wild-type 16S rRNA and attached to a solid phase matrix retains the wild-type 30S subunits. The flow-through of the column contains close to 100% mutant 30S subunits. Toeprinting assays demonstrate that affinity column treatment does not cause significant loss of activity of the specialized particles in initiation complex formation, whereas elongation capacity as determined by poly(Phe) synthesis is only slightly decreased. The method described offers an advantage over total reconstitution from in vitro transcribed mutant 16S rRNA since our 30S subunits contain the naturally occurring base modifications in their 16S rRNA.
Tungsten bridge for the low energy ignition of explosive and energetic materials (2023)

A tungsten bridge device for the low energy ignition of explosive and energetic materials is disclosed. The device is fabricated on a silicon-on-sapphire substrate which has an insulating bridge element defined therein using standard integrated circuit fabrication techniques. Then, a thin layer of tungsten is selectively deposited on the silicon bridge layer using chemical vapor deposition techniques. Finally, conductive lands are deposited on each end of the tungsten bridge layer to form the device. It has been found that this device exhibits substantially shorter ignition times than standard metal bridges and foil igniting devices. In addition, substantially less energy is required to cause ignition of the tungsten bridge device of the present invention than is required for common metal bridges and foil devices used for the same purpose.
SOI for asynchronous dynamic circuits (2001)

Article Share on SOI for asynchronous dynamic circuits Authors: R. V. Joshi IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NY IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NYView Profile , W. Huang IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NY IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NYView Profile , C. T. Chuang IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NY IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NYView Profile Authors Info & Claims GLSVLSI '01: Proceedings of the 11th Great Lakes symposium on VLSIMarch 2001 Pages 37–42https://doi.org/10.1145/368122.368734Online:01 March 2001Publication History 0citation158DownloadsMetricsTotal Citations0Total Downloads158Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Massive MIMO full-duplex for high-efficiency next generation WLAN systems (2016)

In this paper, massive multiple-input multiple-output (massive MIMO) and full-duplex communications (FDC) are considered together for high efficiency next generation wireless LAN (WLAN) systems such as IEEE 802.11ax or beyond. The proposed scheme allocates different carrier sensing thresholds by applying the joint spatial division and reuse (JSDR) scheme and is able to enhance the efficiency of multi-user MIMO (MU-MIMO) protocols by reducing the protocol overhead. Finally, FDC is applied to improve the spectral efficiency of the WLAN systems.
Detection of Genuine and Posed Facial Expressions of Emotion: Databases and Methods (2021)

Facial expressions of emotion play an important role in human social interactions. However, posed expressions of emotion are not always the same as genuine feelings. Recent research has found that facial expressions are increasingly used as a tool for understanding social interactions instead of personal emotions. Therefore, the credibility assessment of facial expressions, namely, the discrimination of genuine (spontaneous) expressions from posed (deliberate/volitional/deceptive) ones, is a crucial yet challenging task in facial expression understanding. With recent advances in computer vision and machine learning techniques, rapid progress has been made in recent years for automatic detection of genuine and posed facial expressions. This paper presents a general review of the relevant research, including several spontaneous vs. posed (SVP) facial expression databases and various computer vision based detection methods. In addition, a variety of factors that will influence the performance of SVP detection methods are discussed along with open issues and technical challenges in this nascent field.
Difference-metric Viterbi decoding of multilevel class-IV partial-response signals (1994)

The paper describes the decoding of unconstrained L-ary signals (L/spl ges/2) transmitted over a noisy partial-response channel with transfer function 1-D/sup 2/. Signals received at even and odd sampling times are independently decoded in a pipeline fashion. After stating the known results for full-state maximum-likelihood sequence decoding, a 2-state decoding algorithm is introduced in which the difference between the metrics of the retained two most-likely states is iteratively computed. An analysis of its error-event probability shows that two types of error events are most likely, regular free-distance events and induced free-distance events. The latter cause only a rather small degradation of error performance compared to full-state decoding. In addition, the symbol-error probability for modulo-L encoded user symbols and decoding with finite decoding delay is computed. The 2-state decoder can be realized for arbitrary values of L with low hardware complexity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Editorial (2000)

JEEMS Journal of East European Management Studies , Seite 101 - 102
Dissecting tunicamycin biosynthesis by genome mining: cloning and heterologous expression of a minimal gene cluster (2010)

Tunicamycin nucleoside antibiotics were the first known to target the formation of peptidoglycan precursor lipid I in bacterial cell wall biosynthesis. They have also been used extensively as inhibitors of protein N-glycosylation in eukaryotes, blocking the biogenesis of early intermediate dolichyl-pyrophosphoryl-N-acetylglucosamine. Despite their unusual structures and useful activities, little is known about their biosynthesis. Here we report identification of the tunicamycin biosynthetic genes in Streptomyces chartreusis following genome sequencing and a chemically-guided strategy for in silico genome mining that allowed rapid identification and unification of an operon fractured across contigs. Heterologous expression established a likely minimal gene set necessary for antibiotic production, from which a detailed metabolic pathway for tunicamycin biosynthesis is proposed. These studies unlock a comprehensive and unusual toolbox of biosynthetic machinery with which to create variants of this important natural product, allowing possible improved understanding of the mode of action and facilitating future redesign. We anticipate that these results will enable the generation of altered specific inhibitors of diverse carbohydrate-processing enzymes, including improved targeting of lipid I biosynthesis.
A multiple domain environment for efficient simulation (2002)

The paper presents a concurrent simulation methodology for digital logic experimentation, which supports a multiple experiment environment for creating and maintaining scenarios of independent experiments without being exhaustive. It efficiently compresses multiple experiments in a single simulation and requires no pre-analysis of the circuit. In addition, scenarios can be created which allow experiments to interact with each other and spawn offspring experiments should new behaviors arise. The user initializes the simulation with independent experiments and the interactions are dynamically created if necessary. By utilizing the similarity among experiments, we gain efficiency in storage and CPU time without resorting to parallel hardware. Providing this capability in digital logic simulators, allows more test cases to be run in less time, provides the exact location and causes of every behavior and can be used to track the signature paths of test patterns for coverage analysis. We describe the multiple experiment algorithms, discuss the function list that makes dynamic interactions possible and report on its effectiveness for attacking an exhaustive simulation problem such as Multiple Stuck-at Fault simulations for digital logic. New directions for this type of testing methodology and applicability to other model types for creating experiment scenarios are also discussed based on our results.
Navigation of the Twin GRAIL Spacecraft into Science Formation at the Moon (2012)

On February 29, 2012 the twin NASA Gravity Recovery And Interior Laboratory (GRAIL) spacecraft, Ebb and flow, achieved precise synchronized formation for collecting highly sensitive lunar gravity data. This was accomplished after performing a total of 27 propulsive maneuvers between the two spacecraft (13 on Ebb, 14 on Flow) over six months. Each 300 kg GRAIL spacecraft independently flew a 3.8-month, low-energy trajectory to reach the Moon after separation from the launch vehicle on September 10, 2011. The space craft were captured into 11.5 hr co- planar polar orbits after performing Lunar Orbit Insertion (LOI) maneuvers on New Years Eve (Dec 31, 2011) and New Years Day (Jan 1, 2012), respectively for Ebb, and Flow. Once captured, each spacecraft performed clusters of period reduction maneuvers to bring their orbit periods down to just less than 2 hrs. Finally, the orbiters we replaced into science formation by performing five strategic maneuvers (2 on Ebb, 3 on Flow). These maneuvers ensured 3 months of orbit life time with mean altitudes of 55 km and separations of 82-217 km by targeting the orbits' eccentricity vectors to specific locations. This paper will discuss the navigation strategy and performance of the twin GRAIL spacecraft from the September 10, 2011 launch through the end of the Prime Mission Science Phase in June 2012.
Dependence of Magnetic Anisotropy in Co$_{20}$Fe$_{60}$B$_{20}$ Free Layers on Capping Layers in MgO-Based Magnetic Tunnel Junctions with In-Plane Easy Axis (2012)

Perpendicular magnetic anisotropy (PMA) in Co20Fe60B20 films depending on the adjacent layers of Ta, Ru, and MgO was studied for reduction of switching current density Jc0 in in-plane magnetic tunnel junctions (MTJs). A MgO layer reduces the out-of-plane saturation field (Hs) of in-plane easy axis Co20Fe60B20 films by inducing a strong PMA at the Co20Fe60B20/MgO interface. The PMA is not affected much by the crystallinity in Co20Fe60B20 films with different capping layers. MTJ with a MgO capping layer shows a lower Jc0 than that with a Ru capping layer, in accordance with the reduction of Hs.
Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer. (2000)

Hypoxia limits tumor growth but selects for higher metastatic potential. We tested the functional activity of hypoxia-inducible factor-1 (HIF-1) in prostate cell lines ranging from normal epithelial cells (PrEC), hormone-dependent LNCaP, hormone-independent DU145, PC-3 to highly metastatic PC-3M cancer cell lines. We found that HIF-1-stimulated transcription was the lowest in PrEC and LNCaP cells and the highest in PC-3M cells. The induction by hypoxia of the HIF-1 dependent genes Cap43 and GAPDH was the highest in the most aggressive PC-3M cancer cells. Because these advanced prostate cancer cell lines have lost p53 function, this further shifts a balance from p53 to HIF-1 transcriptional regulation, and a high ratio of HIF-1-dependent:p53-dependent transcription was a marker of the advanced malignant phenotype. Transient transfection of HIF-1alpha expression vector induced transcription from p21 promoter construct in prostate cancer cell lines. Furthermore, hypoxia slightly induced p21 mRNA in these cells. However, neither expression of p21 nor hypoxia caused growth arrest in PC-3M cells. Therefore, high inducibility of HIF-1-dependent genes, loss of p53 functions with high ratio of HIF-1-dependent:p53-dependent transcription, and loss of sensitivity to p21 inhibition is a part of hypoxic phenotype associated with aggressive cancer behavior.
Acute and Chronic Administrations of<i>Rheum palmatum</i>Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction (2012)

The rhizome of Rheum palmatum (RP) is a commonly used herb in clinical Chinese medicine. Phenytoin (PHT) is an antiepileptic with narrow therapeutic window. This study investigated the acute and chronic effects of RP on the pharmacokinetics of PHT in rat. Rats were orally administered with PHT (200 mg/kg) with and without RP decoction (single dose and seven doses of 2 g/kg) in a crossover design. The serum concentrations of PHT, PHT glucuronide (PHT-G), 4-hydroxyphenytoin (HPPH), and HPPH glucuronide (HPPH-G) were determined by HPLC method. Cell line models were used to identify the underlying mechanisms. The results showed that coadministration of single dose or multiple doses of RP significantly decreased the C(max) and AUC(0-t) as well as the K(10) of PHT, PHT-G, HPPH, and HPPH-G. Cell line studies revealed that RP significantly induced the P-gp-mediated efflux of PHT and inhibited the MRP-2-medicated transport of PHT and HPPH. In conclusion, acute and chronic coadministrations of RP markedly decreased the oral bioavailability of PHT via activation of P-gp, although the MRP-2-mediated excretion of PHT was inhibited. It is recommended that caution should be exercised during concurrent use of RP and PHT.
Prediction Modeling Using EHR Data (2010)

Heart failure was predicted more than 6 months before clinical diagnosis, with AUC of about 0.76, using logistic regression and Boosting. These results were achieved even with strict model selection criteria. SVM had the poorest performance, possibly because of imbalanced data.
Induction of chirality: experimental evidence of atropisomerism in azapeptides (2012)

Methylation of the peptide bond in model azadipeptides leads to the E configuration and hence to atropisomerism due to a restricted rotation around the N-N axis.
Abstracts of lectures (2001)

Beregninger av forinntaket til frittgende reinsdyr om vinteren
The accuracy of 'power' maps to display curvature data in corneal topography systems. (1994)

The direct correlation between corneal curvature and power with which clinicians are familiar is not valid in the peripheral regions measured by videokeratographic devices. Topographic devices measure curvature, which should not be interpreted as corneal power except in the central region. A recommendation to device manufacturers is to display "color curvature maps" instead of color dioptric maps, and to label the color bar with curvature values instead of power.
The use of <i>in vitro</i> model systems to study dental biofilms associated with caries: a short review (2015)

A dental biofilm forms a distinct environment where microorganisms live in a matrix of extracellular polysaccharides. The biofilm favors certain bacteria and creates a habitat that functions differently compared to planktonic bacteria. Reproducible model systems which help to address various questions related to biofilm formation, the process of caries development, and its prevention are needed and are continuously developed. Recent research using both batch culture, continuous culture and flow cells in caries biofilm formation is presented. The development of new techniques and equipment has led to a deeper understanding of how caries biofilms function. Biofilm models have also been used in the development of materials inhibiting secondary caries. This short review summarizes available models to study these questions.
Prognostic impact of <i>DNMT3A</i> mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemia (2011)

We have confirmed the high incidence of DNMT3A mutations in patients with AML with IR cytogenetics. Patients with DNMT3A mutations relapse more often and have inferior OS when only patients achieving CR are analyzed. 'Double-mutated' patients have a very poor prognosis.
Hemostats, sealants, and adhesives III: a new update as well as cost and regulatory considerations for components of the surgical toolbox (2012)

The hemostat, sealant, and adhesive components of the surgical toolbox continue to evolve and enter clinical practice at a rapid rate. The goal of this comprehensive, sequential review is to update these components to include those now available (February 2012) as well as to explore cost and regulatory factors that impact the development and use of these materials. A unique system of definitions for organizing these components based on group, category, and class is used as a means of improving the understanding and appropriate use of these materials. The system will be used here to present the most recent additions to the toolbox, which are evaluated based on safety, efficacy, usability, and cost. These new additions include pooled human plasma fibrinogen and thrombin embedded in an equine collagen patch for cardiac surgical hemostasis, polyethylene glycol (PEG) and human serum albumin for lung surgical pneumostasis, modified PEG and trilysine amine for spinal sealing, octyl and butyl lactoyl cyanoacrylate for vascular sealing, and a variety of octyl and butyl cyanoacrylates with or without dyes and/or polyester mesh for skin closure with the creation of a bacterial barrier. The system of definitions will also be used to clarify key strategies in the current health care environment for reducing costs and for increasing understanding of Food and Drug Administration regulatory decisions for these materials.
Self‐Healing Polymer Electrolytes Formed via Dual‐Networks: A New Strategy for Flexible Lithium Metal Batteries (2018)

A novel polymer electrolyte with mechanically robust and self-healing properties was fabricated through a dual-network structure, crosslinked by quadruple hydrogen bonding and chemical bonding. The dynamic ureido-pyrimidinone (UPy) dimers were the first network in the polymer matrix. This group endows the polymer electrolyte with good self-healing capacity and improves the reliability and lifetime of the polymer lithium batteries. The crosslinked polyethylene glycol-bis-carbamate dimethacrylate (PEGBCDMA) is the second network and guarantees dimensional stability and good mechanical properties of the polymer electrolyte. The dual-network self-healing polymer electrolyte (DN-SHPE) exhibits improved ionic conductivity versus the polymer electrolyte fabricated by poly(ethylene glycol) diacrylate (PEGDA). It has high thermal stability (up to 350 °C) and excellent interfacial stability with the electrodes. When the DN-SHPE-based cells were fabricated with LiFePO<sub>4</sub> and Li metal, the resulting cells show good reversible specific capacity and considerable rate capability. Moreover, the pouch cell could maintain electrochemical function even under deformation or folding conditions.