gebhart/patrepeval huggingface dataset:
Differential distribution in rat brain of mu opioid receptor carboxy terminal splice variants MOR-1C-like and MOR-1-like immunoreactivity: Evidence for region-specific processing (2000)

The present study examined immunohistochemically the regional distribution of the mu opioid receptor splice variant MOR-1C by using a rabbit antisera generated against the C-terminal peptide sequences and compared it with MOR-1. Overall, the distribution of MOR-1C-like immunoreactivity (-LI) differed from MOR-1-LI. Both MOR-1C-LI and MOR-1-LI were prominent in a few central nervous system regions, including the lateral parabrachial nucleus, the periaqueductal gray, and laminae I-II of the spinal trigeminal nuclei and the spinal cord. In the striatum, hippocampal formation, presubiculum and parasubiculum, amygdaloid nuclei, thalamic nuclei, locus coeruleus, and nucleus ambiguous MOR-1-LI predominated, whereas MOR-1C-LI was absent or sparse. Conversely, MOR-1C-LI exceeded MOR-1-LI in the lateral septum, the deep laminae of the spinal cord, and most hypothalamic nuclei such as the median eminence, periventricular, suprachiasmatic, supraoptic, arcuate, paraventricular, ventromedial, and dorsomedial nuclei. Double-labeling studies showed colocalization of the two receptors in neurons of the lateral septum, but not in the median eminence or in the arcuate nucleus, even though both MOR-1 isoforms were expressed. Because both MOR-1 and MOR-1C are derived from the same gene, these differences in regional distribution represent region-specific mRNA processing. The regional distributions reported in this study involve the epitope seen by the combinations of exons 7, 8, and 9. However, if other MOR-1 variants containing exons 7, 8, and 9 exist, the antisera would not distinguish between them and MOR-1C.
Adapting content to client resources in the Internet (2003)

We address the delivery of composite multimedia documents, namely Web pages, over the Internet to clients with diverse resources and capabilities. We do so by adapting the multimedia content to meet the client device characteristics. We model the adaptation process as a resource allocation problem in a generalized rate-distortion framework. In this framework, we address the issue of both multiple media types in a Web document and multiple resource types at the client. We extend this framework to allow prioritization on the content items in a Web document. We illustrate our content adaptation technique with a Web server that adapts multimedia news stories to clients as diverse as workstations, PDAs and cellular phones.
Uncoupling Protein-3 Expression in Rodent Skeletal Muscle Is Modulated by Food Intake but Not by Changes in Environmental Temperature (1998)

A new member of the uncoupling protein (UCP) family called UCP3 has recently been cloned and shown to be highly expressed in skeletal muscle of rodents and humans. In the present study, UCP3 was overexpressed in C2C12 myoblasts where it acts as an uncoupling protein. Changes in UCP3 mRNA expression were examined in rodent muscles under conditions known to modulate thermogenesis in brown adipose tissue. In skeletal muscle, UCP3 expression did not change in response to 48 h of cold exposure (6 degrees C), whereas it was decreased by 81% or increased 5.6-fold by 1 week of 50% food restriction or fasting, respectively. It was also decreased by 36% in soleus muscle of obese (fa/fa) as compared with lean Zucker rats. The unexpected rise of UCP3 mRNA level induced by fasting did not change in vitro muscle basal heat production rate but decreased by 31% the capacity to produce heat in response to the uncoupler carbonylcyanide p-trifluoromethoxyphenylhydrazone. This decrease may reflect underlying uncoupling by UCP3. Up-regulation of UCP3 mRNA after a 24-h fast was still observed in mice exposed at thermoneutrality. These results show that the increase in UCP3 expression induced by fasting is associated with the maintenance of thermogenesis measured in muscle in vitro and is not modulated by environmental temperature. The notion that UCP3 expression is modulated by food intake is of importance to better understand the pathophysiology of obesity in humans.
Hydrocracing catalyst composition and method of making same (1985)

A hydrocracking catalyst composition comprising metals of Group VIb and Group VIII deposited on a carrier material consisting of Y-zeolite and one or more members of the group consisting of alumina/zinc oxide, alumina/boria and alumina/silica/magnesia, the greater part of the pores of said composition having a diameter of 70-110 A even when measured by nitrogen adsorption method or by means of a porosimeter under pressure. The catalyst composition having the pores as mentioned above is made by using, as an alumina component of the carrier material, an alumina cake obtained from an amorphous alumina hydrate slurry containing a pseudoboehmite having a crystal size grown in the range of 40 to 80 A.
Perceived Intensity and Discrimination Ability for Lingual Electrotactile Stimulation Depends on Location and Orientation of Electrodes (2017)

Malfunctioning sensory systems can severely impact quality of life and repair is not always possible. One solution, called sensory substitution, is to use another sensory system to bring lost information to the brain. This approach often involves the use of bioengineered devices that electrically stimulate somatosensory fibers. Interestingly, the tongue is an ideal location for electrotactile stimulation due to its dense innervation, moisture, and protected environment. Success with transmitting visual and vestibular information through the tongue indicates promise for future applications. However, sensitivity and discrimination ability varies between individuals and across the tongue surface complicating efforts to produce reliable and consistent sensations. The goals of the present study were to investigate these differences more precisely to better understand the mechanosensory innervation of the tongue so that future electrotactile devices can be designed more effectively. Specifically, we tested whether stimulation of certain regions of the tongue consistently result in better perception, whether the spacing of stimulating electrodes affects perceived intensity, and whether the orientation of electrodes affects perceived intensity and discrimination. To test these hypotheses, we built a custom tongue stimulation device, recruited 25 participants, and collected perceived intensity and discrimination data. We then subjected the data to thorough statistical analyses. Consistent with previous studies, we found that stimulation of the anterior medial tongue region was perceived as more intense than stimulation of lateral and posterior regions. This region also had the best discrimination ability for electrodes. Dividing the stimulated tongue area into 16 distinct regions allowed us to compare perception ability between anterior and posterior regions, medial and lateral regions, and the left and right sides of the tongue. Stimulation of the most anterior and medial tongue resulted in the highest perceived intensity and the best discrimination ability. Most individuals were able to perceive and discriminate electrotactile stimulation better on one side of the tongue, and orientation of stimulating electrodes affected perception. In conclusion, the present studies reveal new information about the somatosensory innervation of the tongue and will assist the design of future electrotactile tongue stimulation devices that will help provide sensory information to people with damaged sensory systems.
Elemental fluorine. Part 1. Synthesis of fluoroaromatic compounds (1996)

Direct fluorination of 4-fluorobenzoic acid, as a model substrate in a variety of reaction media, shows that 98% formic acid and concentrated sulfuric acid are excellent for promoting electrophilic fluorination. A high degree of fluorination may be achieved using concentrated sulfuric acid, showing that in this medium fluorine will act as a powerful electrophile.
The MarCon algorithm: A systematic market approach to distributed constraint problems (1999)

MarCon (Market-based Constraints) applies market-based control to distributed constraint problems. It offers a new approach to distributing constraint problems that avoids challenges faced by current approaches in some problem domains, and it provides a systematic method for applying markets to a wide array of problems. Constraint agents interact with one another via the variable agents in which they have a common interest, using expressions of their preferences over sets of assignments. Each variable integrates this information from the constraints interested in it and provides feedback that enables the constraints to shrink their sets of assignments until they converge on a solution. MarCon originated in a system for supporting human product designers, and its mechanisms are particularly useful for applications integrating human and machine intelligence to explore implicit constraints. MarCon has been tested in the domain of mechanical design, in which its set-narrowing process is particularly useful.
Enhancement of critical current densities of powder-in-tube processed MgB<sub>2</sub>tapes by using MgH<sub>2</sub>as a precursor powder (2002)

We investigated the effect of starting powder on the microstructure and superconducting properties of MgB2 tapes prepared by a powder-in-tube technique. Two kinds of powder mixtures, Mg + B and MgH2 + B, were used as precursors. When using the mixture of Mg + B, carbon-steel (CS) sheaths reacted with B, and FexB (x = 1 and 2) was formed. This brought about a decrease in the density of the MgB2 core and, hence, a low critical current density (Jc). On the other hand, we found that the mixture of MgH2 + B was effective in suppressing the formation of FexB and obtaining a high density of the core layer. The Jc values of the tapes prepared using the mixture of MgH2 + B were about twice as large as those prepared using the mixture of Mg + B and reached 1600 A cm−2 at 4.2 K and 10 T. This is higher than that of the CS-sheathed MgB2 tapes prepared with MgB2 powder.
Productive Generation of Compound Words in Statistical Machine Translation (2011)

In many languages the use of compound words is very productive. A common practice to reduce sparsity consists in splitting compounds in the training data. When this is done, the system incurs the risk of translating components in non-consecutive positions, or in the wrong order. Furthermore, a post-processing step of compound merging is required to reconstruct compound words in the output. We present a method for increasing the chances that components that should be merged are translated into contiguous positions and in the right order. We also propose new heuristic methods for merging components that outperform all known methods, and a learning-based method that has similar accuracy as the heuristic method, is better at producing novel compounds, and can operate with no background linguistic resources. 1
Improved quantitative mobility spectrum analysis for Hall characterization (1998)

We present an improved quantitative mobility spectrum analysis (i-QMSA) procedure for determining free electron and hole densities and mobilities from magnetic-field-dependent Hall and resistivity measurements on bulk or layered semiconductor samples. The i-QMSA technique is based on a fundamentally new approach, which optimizes the fit to the conductivity tensor components and their slopes by making those adjustments in the mobility spectra that result in the greatest error reduction. Empirical procedures for manipulating the mobility spectra are also introduced, with the dual purpose of reducing the error of the fit and simplifying the shape of the spectra to minimize the presence of unphysical artifacts. A fully automated computer implementation of the improved QMSA is applied to representative synthetic and real data sets involving various semiconductor material systems. These results show that, as compared with previous approaches, the presented algorithm maximizes the information that may be extracted from a given data set, and is suitable for use as a standard tool in the characterization of semiconductor material and device transport properties.
Synthesis, Electrochemical and Optical Properties of Stable Yellow Fluorescent Fluoranthenes (2010)

A novel series of thermally stable yellow light emitting fluoranthenes with an amine donor and a nitrile acceptor was prepared from a ketene-S,S-acetal under mild conditions without using an organometal catalyst. The organic light emitting device of yellow fluoranthene 10b exhibited substantially low turn-on voltage (2.6 V) and maximum brightness of 470 Cd/m(2) with luminance efficiency of 2.0 Cd/A without using any dopant.
Synthesis and physical properties of liquid-crystalline polyesters derived from 4,4'-dihydroxybicyclohexyl (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and physical properties of liquid-crystalline polyesters derived from 4,4'-dihydroxybicyclohexylA. Coassolo, M. Foa, D. Dainelli, R. Scordamaglia, L. Barino, L. L. Chapoy, F. Rustichelli, B. Yang, and G. TorquatiCite this: Macromolecules 1991, 24, 8, 1701–1709Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ma00008a001https://doi.org/10.1021/ma00008a001research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sonar: Detecting SS7 Redirection Attacks with Audio-Based Distance Bounding (2018)

The global telephone network is relied upon by billions every day. Central to its operation is the Signaling System 7 (SS7) protocol, which is used for setting up calls, managing mobility, and facilitating many other network services. This protocol was originally built on the assumption that only a small number of trusted parties would be able to directly communicate with its core infrastructure. As a result, SS7 - as a feature - allows all parties with core access to redirect and intercept calls for any subscriber anywhere in the world. Unfortunately, increased interconnectivity with the SS7 network has led to a growing number of illicit call redirection attacks. We address such attacks with Sonar, a system that detects the presence of SS7 redirection attacks by securely measuring call audio round-trip times between telephony devices. This approach works because redirection attacks force calls to travel longer physical distances than usual, thereby creating longer end-to-end delay. We design and implement a distance bounding-inspired protocol that allows us to securely characterize the round-trip time between the two endpoints. We then use custom hardware deployed in 10 locations across the United States and a redirection testbed to characterize how distance affects round trip time in phone networks. We develop a model using this testbed and show Sonar is able to detect 70.9% of redirected calls between call endpoints of varying attacker proximity (300-7100 miles) with low false positive rates (0.3%). Finally, we ethically perform actual SS7 redirection attacks on our own devices with the help of an industry partner to demonstrate that Sonar detects 100% of such redirections in a real network (with no false positives). As such, we demonstrate that telephone users can reliably detect SS7 redirection attacks and protect the integrity of their calls.
Real-Time Data Center Transient Analysis (2011)

A software tool was developed to predict the transient cooling performance of data centers and to explore various alternatives in real-time for data center design and management purposes. Cooling performance can be affected by factors such as room architecture, rack population and layout, connections between cooler fans and UPSs, chilled water pumps and UPSs, the size of the chilled water storage tank, etc. The available transient cooling runtime is mainly dictated by the system stored cooling capacity and the total load in the data center. This paper discusses the transient response of data centers to different design and failure scenarios and details a comprehensive and efficient approach for simulating this performance.
Temperature-Sensitive Mutants of Influenza A Virus: Transfer of the Two Temperature-Sensitive Lesions in the Udorn/72- <i>ts</i> -1A2 Virus to the A/Hong Kong/123/77 (H1N1) Wild-Type Virus (1980)

The influenza A/Udorn/72-ts-1A2 virus possesses temperature-sensitive mutations in the genes coding for the P1 and P3 polymerase proteins. It is being evaluated as a donor of its attenuating temperature-sensitive genes to produce recombinant live vaccine strains of epidemic variants of influenza A virus. Transfer of the P1 and P3 genes to two viruses within the H3N2 subtype of influenza A virus (i.e., the A/Victoria/3/75 and A/Alaska/6/77 viruses) conferred on each variant the following properties: (i) 37 degrees C shutoff temperature for plaque formation, (ii) almost complete restriction of viral replication in the lungs, (iii) a 100-fold restriction of viral replication in the nasal turbinates, and (iv) genetic stability after replication in hamsters. This study was undertaken to determine whether the transfer of the two ts-1A2 temperature-sensitive genes into a virus belonging to the H1N1 subtype (i.e., the A/Hong Kong/123/77 virus) would result in a restriction of replication in vitro and in vivo comparable to that observed with the previously studied H3N2 recombinant viruses in hamsters. This was found to be the case. In addition, infection of hamsters with the A/Hong Kong/77-ts-1A2 virus induced significant resistance to infection with wild-type A/Hong Kong/77 virus. Thus, the two ts-1A2 temperature-sensitive genes attenuated influenza A viruses belonging to two distinct subtypes to a specific and predictable level. An unexpected genetic interaction was observed between several A/Hong Kong/77-ts-1A2 segregants bearing the group 5 (P1) temperature-sensitive lesion. One interpretation of these results is that intracistronic complementation occurred between these segregants.
Vertical multi-bit resonant tunneling diode memory cell (2002)

We propose and demonstrate a new resonant-tunneling diode (RTD) based memory cell in which bits are stacked vertically while their addressing requires only two physical contacts to the vertically integrated RTDs (VIRTDs). Toward meeting the ultra low static power requirements we have developed record low current density (down to 0.16 A/cm2) InP based RTDs with 300 K peak-to-valley current ratios (PVCRs) ranging from 2.9 to 18.
Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype (2002)

Histamine is an aminergic neurotransmitter that is localized in the CNS and in peripheral tissues. To date, four histamine receptors have been identified, and the H3 receptor, which was recently cloned, is predominantly expressed in the CNS. The peripheral functions of histamine have been investigated intensively using available molecular and pharmacological tools, and the molecular identification of the H3 receptor opens up new possibilities for investigating the role of histamine in central tissues. To understand the biological function of the histamine presynaptic autoreceptor H3, we inactivated the receptor through homologous recombination. H3(–/–) mice manifest mild obese phenotypes that are characterized by increases in body weight, food intake, and adiposity and by reductions in energy expenditure. Consistent with these observations, homozygous null mice have insulin and leptin resistance, increased levels of plasma leptin and insulin, and decreased levels of histamine in the hypothalamic/thalamic region of their brains coupled with increased histamine turnover. The expression of UCP1 in brown adipose tissue and of UCP3 in brown adipose tissue, white adipose tissue, and skeletal muscle is decreased in H3(–/–) mutants, and the anorexigenic activity of thioperamide is not observed. These results suggest that neuronal histamine is a mediator of body-weight homeostasis and that neuronal histamine functions through H3 receptors in mice.
Nonlocal based Super Resolution with rotation invariance and search window relocation (2012)

In this paper, we present a novel method for Super Resolution (SR) reconstruction with rotation invariance and search window relocation. To combine complementary information in observed images to generate a higher resolution image, we first relocate search window to involve potential similar patches and then use rotation invariance similarity measure to find accurate similar patches. Comparing with Nonlocal Means SR, our algorithm can find more similar patches for weighted average. Experimental results demonstrate superior performance of the proposed method in terms of both objective measurements and subjective evaluation.
Micro Neutralization (MN) Assay of Influenza Viruses with Monoclonal Antibodies (2016)

The human monoclonal antibodies generated from single human B cells were tested to characterize their ability to neutralize virus infectivity. The microneutralization assay is a highly sensitive and specific assay for detecting virus-specific neutralizing antibodies to influenza viruses. This protocol is to measure the ability of human monoclonal antibody to neutralize influenza virus by microneutralization assay.
ChemInform Abstract: Unusual Rapid Hydroboration of Alkenes Using Diborane in Chlorohydrocarbon Solvents. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Controlling Toroidal Moment by Means of an Inhomogeneous Static Field: An<i>Ab Initio</i>Study (2006)

A first-principles-based approach is used to show (i) that stress-free ferroelectric nanodots under open-circuit-like electrical boundary conditions maintain a vortex structure for their local dipoles when subject to a transverse inhomogeneous static electric field, and, more importantly, (ii) that such a field leads to the solution of a fundamental and technological challenge: namely, the efficient control of the direction of the macroscopic toroidal moment. The effects responsible for such striking features are revealed and discussed.