gebhart/patrepeval huggingface dataset:
FTIR Study on the Formation of TiO<sub>2</sub> Nanostructures in Supercritical CO<sub>2</sub> (2006)

TiO(2) nanospherical and fibered structures were obtained via a one-step sol-gel method in supercritical carbon dioxide (scCO(2)) involving polycondensation of the alkoxide monomers titanium isopropoxide (TIP) and titanium butoxide (TBO) with acetic acid (HAc). The resulting materials were characterized by means of electron microscopy (SEM and TEM), X-ray diffraction (XRD), thermal analysis (TGA), and attenuated total reflection Fourier transmission infrared (ATR-FTIR) analysis. Depending on the experimental conditions, TiO(2) anatase nanospheres with a diameter of 20 nm or TiO(2) anatase/rutile nanofibers with a diameter of 10-100 nm were obtained. Fiber formation was enhanced by a higher HAc/Ti ratio and the use of the titanium isopropoxide (TIP) monomer. The mechanism of the microstructure formation was studied using in situ FTIR analysis in scCO(2). The FTIR results indicated that the formation of nanofibers was favored by a titanium hexamer that leads to one-dimensional condensation, while nanospheres were favored by a hexamer that permits three-dimensional condensation.
Development of a computer‐aided diagnostic scheme for detection of interval changes in successive whole‐body bone scans (2006)

Bone scintigraphy is the most frequent examination among various diagnostic nuclear medicine procedures. It is a well-established imaging modality for the diagnosis of osseous metastasis and for monitoring osseous tumor response to chemotherapy and radiation therapy. Although the sensitivity of bone scan examinations for detection of bone abnormalities has been considered to be relatively high, it is time consuming to identify multiple lesions such as bone metastases of prostate and breast cancers. In addition, it is very difficult to detect subtle interval changes between two successive abnormal bone scans, because of variations in patient conditions, the accumulation of radioisotopes during each examination, and the image quality of gamma cameras. Therefore, we developed a new computer-aided diagnostic (CAD) scheme for the detection of interval changes in successive whole-body bone scans by use of a temporal subtraction image which was obtained with a nonlinear image-warping technique. We carried out 58 pairs of successive bone scans in which each scan included both posterior and anterior views. We determined 107 "gold-standard" interval changes among the 58 pairs based on the consensus of three radiologists. Our computerized scheme consisted of seven steps, i.e., initial image density normalization on each image, image matching for the paired images, temporal subtraction by use of the nonlinear image-warping technique, initial detection of interval changes by use of temporal-subtraction images, image feature extraction of candidates of interval changes, rule-based tests by use of 16 image features for removing some false positives, and display of the computer output for identified interval changes. One hundred seven gold standard interval changes included 71 hot lesions (uptake was increased compared with the previous scan, or there was new uptake in the current scan) and 36 cold lesions (uptake was decreased or disappeared) for anterior and posterior views. The overall sensitivity in the detection of interval changes, including both hot and cold lesions evaluated by use of the resubstitution and the leave-one-case-out methods, were 95.3%, with 5.97 false positives per view, and 83.2% with 6.02, respectively. The temporal subtraction image for successive whole-body bone scans has the potential to enhance the interval changes between two images, which also can be quantified. Furthermore, the CAD scheme for the detection of interval changes by use of temporal subtraction images would be useful in assisting radiologists' interpretation on successive bone scan images.
Business process verification with constraint temporal answer set programming (2013)

Abstract The paper provides a framework for the verification of business processes, based on an extension of answer set programming (ASP) with temporal logic and constraints. The framework allows to capture expressive fluent annotations as well as data awareness in a uniform way. It allows for a declarative specification of a business process but also for encoding processes specified in conventional workflow languages. Verification of temporal properties of a business process, including verification of compliance to business rules, is performed by bounded model checking techniques in Answer Set Programming, extended with constraint solving for dealing with conditions on numeric data.
Hyperpolarized <sup>3</sup>He diffusion MRI and histology in pulmonary emphysema (2006)

Diffusion MRI of hyperpolarized (3)He shows that the apparent diffusion coefficient (ADC) of (3)He gas is highly restricted in the normal lung and becomes nearly unrestricted in severe emphysema. The nature of this restricted diffusion provides information about lung structure; however, no direct comparison with histology in human lungs has been reported. The purpose of this study is to provide information about (3)He gas diffusivity in explanted human lungs, and describe the relationship between (3)He diffusivity and the surface area to lung volume ratio (SA/V) and mean linear intercept (L(m)) measurements--the gold standard for diagnosis of emphysema. Explanted lungs from patients who were undergoing lung transplantation for advanced COPD, and donor lungs that were not used for transplantation were imaged via (3)He diffusion MRI. Histological measurements were made on the same specimens after they were frozen in the position of study. There is an inverse correlation between diffusivity and SA/V (and a positive correlation between diffusivity and L(m)). An important result is that restricted (3)He diffusivity separated normal from emphysematous lung tissue more clearly than the morphometric analyses. This effect may be due to the smaller histologic sampling size compared to the MRI voxel sizes.
Dimerization Is Essential for DNA Binding and Repression by the ArsR Metalloregulatory Protein of Escherichia coli (1997)

Arsenical resistance (ars) operons produce resistance to trivalent and pentavalent salts of the metalloids arsenic and antimony in cells of Escherichia coli. The first gene in the operon, arsR, was previously shown to encode a homodimeric trans-acting metalloregulatory repressor protein. Dimerization of ArsR was investigated using the yeast two-hybrid system in which the ArsR protein was fused to the Saccharomyces cerevisiae GAL4 DNA-binding domain and GAL4 activation domain to produce chimeric proteins. Transcriptional activation of lacZ reporter indicated that dimerization of the ArsR is stable in yeast. The results indicated that residues 1-8 and 90-117 are not required for ArsR dimerization. The genes for a series of truncated ArsR proteins containing six histidine tags were constructed and the proteins purified. The mass of each recombinant protein, as determined by size exclusion chromatography, was consistent with the results from two-hybrid analysis. The results of beta-galactosidase assays in vivo and gel mobility shift assays in vitro showed that dimers retained the ability to bind to the ars promoter and to respond to inducer, whereas monomeric ArsRs did neither. These results suggest that a core sequence of about 80 residues has all of the information necessary for dimerization, repression, and metal recognition.
The application of Web-based technologies on integrated network management (2002)

The emerging Web-based technologies will change the way networks are managed. Currently, network managers have to use expensive, and sometimes, vendor-specific management consoles to view and manipulate network data. What is required now is universal access of management information that is cost-effective, easy-to-use, and allows better interoperability. This paper investigates the requirements for Web-based network management, and examines the major emerging technologies and proposals in this area. It provides a set of guidelines for developing a Web-based network management system. Based on these guidelines, a framework is presented that combines the strengths of a variety of Web-based technologies and proposals.
Molecular and cellular mechanism of angiotensin II-mediated apoptosis (1998)

It is well known that angiotensin II exerts growth promoting effects via the angiotensin II type 1 (AT1) receptor. We have cloned a second type of angiotensin II receptor (AT2 receptor) and demonstrated that this receptor acts as an antagonistic receptor against the AT1 receptor. Moreover, we have demonstrated that the AT2 receptor exerts growth inhibitory and proapoptotic effects by antagonizing the effects of the AT1 receptor and growth factors in several cell lines including vascular smooth muscle cells, cardiomyocytes, neuronal cell (PC12W) and fibroblasts (R3T3). We observed that the AT2 receptor activates tyrosine phosphatase(s) such as mitogen-activated protein (MAP) kinase-phosphatase-1 (MKP-1) and inactivates MAP kinase (extracellular signal-regulated kinase (ERK1 and ERK2)), resulting in Bcl-2 dephosphorylation and up-regulation of Bax. This inactivation of ERK is mediated via Gi protein coupling through its unique intracellular third loop. Moreover, we have demonstrated that interferon regulatory factor (IRF)-1 also up-regulates the AT2 receptor in apoptotic cells, suggesting that the cytokines may play an important role in angiotensin-regulated apoptosis.
Developmental profiles and mentality in preschool children with Prader-Willi syndrome: a preliminary study. (2010)

These findings suggest that the children with PWS show an uneven global developmental delay together with an uneven mental delay. The results of this study should allow clinicians to better understand the developmental functioning of children with PWS and this will help with the planning of treatment strategies.
Calpain‐Dependent Cleavage of Junctophilin‐2 and T‐Tubule Remodeling in a Mouse Model of Reversible Heart Failure (2014)

Disruption of the T-tubule network in heart failure is a reversible process. Gαq-dependent activation of calpain and subsequent proteolysis of JP-2 appear to be the molecular mechanism that leads to T-tubule remodeling, Ca(2+) handling dysfunction, and progression to heart failure in this mouse model.
Multispectral imaging via luminescent down-shifting with colloidal quantum dots (2013)

The high infrared quantum yield, continuous absorption spectrum, and band edge tunability of colloidal quantum dots (QD) has opened up new opportunities to use luminescent down shifting for multispectral imaging in the infrared. We demonstrate a QD sensitized short wavelength infrared (SWIR) camera which is capable of UV-SWIR multispectral imaging. The application of multispectral cameras for UV tagging applications is demonstrated and the extension of this technology to the mid infrared spectral region is discussed.
Department of Defense Dictionary of Military and Associated Terms (2007)

The Department of Defense (DOD) Dictionary of Military and Associated Terms is prepared under the direction of the Joint Chiefs of Staff, in coordination with the Office of the Secretary of Defense, the military Services, and the Defense agencies, for planning and operational usage. The Secretary of Defense has directed its use throughout DOD. Terms defined which are designated by 'DOD' will not be defined othewise within DOD. When a term has been included in the DOD Dictionary, DOD issuances will use the definitions established. The appendix format, as used in the 1968 edition, was modified and all terms and titles, with their meaning, are entered in alphabetical sequence in the main body of the DOD Dictionary.
Systolic architectures for radar CFAR detectors (1991)

The authors discuss several advances in the evolution of radar CFAR (constant false alarm rate) detectors, from the classical mean-level detector to more recent designs using order statistics, or sorted data values. These algorithms can be implemented by modifying the existing running window order statistic filtering techniques used in signal/image processing. Although the signal processing theory of CFAR detection is well advanced, practical applications lag because of the high throughput required in radar. This intensive computational requirement is unlikely to be met by further advances in VLSI technology alone; it must result from parallel processing techniques. Systolic array architectures are proposed for several important CFAR detectors. Techniques for improving the processor utilization efficiency of the proposed array architectures are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes (2017)

The ability to reliably and safely communicate chronically with small diameter (100-300 µm) autonomic nerves could have a significant impact in fundamental biomedical research and clinical applications. However, this ability has remained elusive with existing neural interface technologies. Here we show a new chronic nerve interface using highly flexible materials with axon-like dimensions. The interface was implemented with carbon nanotube (CNT) yarn electrodes to chronically record neural activity from two separate autonomic nerves: the glossopharyngeal and vagus nerves. The recorded neural signals maintain a high signal-to-noise ratio (>10 dB) in chronic implant models. We further demonstrate the ability to process the neural activity to detect hypoxic and gastric extension events from the glossopharyngeal and vagus nerves, respectively. These results establish a novel, chronic platform neural interfacing technique with the autonomic nervous system and demonstrate the possibility of regulating internal organ function, leading to new bioelectronic therapies and patient health monitoring.
Inhibition of Monocyte Chemotaxis to C-C Chemokines by Antisense Oligonucleotide for Cytosolic Phospholipase A2 (1996)

Monocyte chemotactic protein (MCP)-1, a member of the C-C (or beta) branch of the chemokine superfamily, at chemotactic concentrations, induced a rapid release of [3H]arachidonic acid but not of [14C]oleic acid from prelabeled human monocytes. This effect was associated with an increase in the intensity of the immunoreactive band corresponding to the phosphorylated form of cytosolic phospholipase A2, (cPLA2). To address the role of cPLA2 in the induction of monocyte chemotaxis, cells were treated with a specific antisense oligonucleotide. Monocytes cultured in the presence of 10 microM antisense oligonucleotide for 48 h showed a marked decrease (57 +/- 5%; n = 4) of cPLA2 expression, as evaluated by Western blot analysis and a nearly complete inhibition (81.8 +/- 4.2%; n = 3) of [3H]arachidonic acid release in MCP-1-stimulated cells. Monocyte chemotaxis in response to MCP-l also was inhibited in a concentration-dependent manner by cPLA2 antisense oligonucleotide (IC50 = 1.9 +/- 1.1 microM; n = 3), with complete inhibition observed between 3 and 10 microM. No inhibition of chemotactic response was observed in monocytes treated with a control oligonucleotide. Monocyte migration in response to MCP-3, RANTES (regulated on activation normal T cells expressed and secreted), and MIP-1 alpha/LD78 also was inhibited (>70%) in antisense oligonucleotide-treated cells. On the contrary, the chemotactic response elicited by formyl-methionyl-leucyl-phenylalanine and C5a, two "classical" chemotactic agonists, was minimally affected (<20%) by antisense oligonucleotide treatment. These data show that cPLA2 plays a major role in [3H]arachidonic acid release by MCP-1 in human monocytes and provide direct evidence for the involvement of cPLA2 in C-C chemokine-induced monocyte chemotaxis.
New Revelations about the Long-QT Syndrome (1995)

Sudden death, a devastating event for any family, strikes more than 300,000 Americans each year. Cardiac arrhythmias, particularly ventricular arrhythmias, are thought to account for about 11 percent of all sudden deaths. In some cases there appears to be a familial propensity for sudden death. One inherited condition, the Romano–Ward long-QT syndrome, is an autosomal dominant disorder of cardiac repolarization that results in ventricular arrhythmias and sudden death. The long-QT syndrome has been thought to arise from either an abnormality of ion-channel regulation (the myocellular hypothesis) or altered activity of the autonomic nervous system, but definitive proof of either hypothesis . . .
Using variable length 13-ary, radix-4 CSD coefficients to achieve low-area implementations of FIR filters (2003)

Coefficient representations in the Canonical-Signed-Digit (CSD) number system are widely used, because they lead directly to efficient addition/subtraction networks for implementation of weighted sums of 2's-complement input signals in FIR filters. A recent radix-4 generalization of CSD can dramatically reduce network sizes. By combining radix-4 representations of coefficients with techniques for assigning different numbers of bits to different coefficients, we further reduce the area required for implementation. We draw the conclusion from our data that this process can reduce the space required for implementing these kinds of filters; however, a better approach might be to design filters with coefficients that are readily represented in the number representation scheme before implementation.
A comparative study of speech detection methods (1997)

This paper adresses the important problem of speech detection. It describes the implementation of 3 speech detection methods and compares their performance under different signal-to-noise ratio (SNR) and stationarity conditions. The method that dynamically adjusts its thresholds is found to be the most reliable, even under very adverse recording conditions. Yet it is of low complexity and has a very moderate processing delay.
Preparation and Characterization of Cellulose Acetate Film Reinforced with Cellulose Nanofibril (2021)

In this study, cellulose acetate (CA)/cellulose nanofibril (CNF) film was prepared via solvent casting. CNF was used as reinforcement to increase tensile properties of CA film. CNF ratio was varied into 3, 5, and 10 phr (parts per hundred rubbers). Triacetin (TA) and triethyl citrate (TC) were used as two different eco-friendly plasticizers. Two different types of solvent, which are acetone and N-methyl-2-pyrrolidone (NMP), were also used. CA/CNF film was prepared by mixing CA and CNF in acetone or NMP with 10% concentration and stirred for 24 h. Then, the solution was cast in a polytetrafluoroethylene (PTFE) dish followed by solvent evaporation for 12 h at room temperature for acetone and 24 h at 80 °C in an oven dryer for NMP. The effect of solvent type, plasticizers type, and CNF amount on film properties was studied. Good dispersion in NMP was evident from the morphological study of fractured surface and visible light transmittance. The results showed that CNF has a better dispersion in NMP which leads to a significant increase in tensile strength and elastic modulus up to 38% and 65%, respectively, compared with those of neat CA. CNF addition up to 5 phr loading increased the mechanical properties of the film composites.
Real-Time Self-Learning Optimization of Diesel Engine Calibration (2008)

Compression ignition engine technologies have been advanced in the past decade to provide superior fuel economy and high performance. These technologies offer increased opportunities for optimizing engine calibration. Current engine calibration methods rely on deriving static tabular relationships between a set of steady-state operating points and the corresponding values of the controllable variables. While the engine is running, these values are being interpolated for each engine operating point to coordinate optimal performance criteria, e.g., fuel economy, emissions, and acceleration. These methods, however, are not efficient in capturing transient engine operation designated by common driving habits, e.g., stop-and-go driving, rapid acceleration, and braking. An alternative approach was developed recently, which makes the engine an autonomous intelligent system, namely, one capable of learning its optimal calibration for both steady-state and transient operating points in real time. Through this approach, while the engine is running the vehicle, it progressively perceives the driver’s driving style and eventually learns to operate in a manner that optimizes specified performance criteria. The major challenge to this approach is problem dimensionality when more than one controllable variable is considered. In this paper, we address this problem by proposing a decentralized learning control scheme. The scheme is evaluated through simulation of a diesel engine model, which learns the values of injection timing and variable geometry turbocharging vane position that optimize fuel economy and pollutant emissions over a segment of the FTP-75 driving cycle.
The causes and prevention of cancer. (1995)

Epidemiological evidence indicates that avoidance of smoking, increased consumption of fruits and vegetables, and control of infections will have a major effect on reducing rates of cancer. Other factors include avoidance of intense sun exposure, increases in physical activity, and reduction of alcohol consumption and possibly red meat. A substantial reduction in breast cancer is likely to require modification of sex hormone levels, and development of practical methods for doing so is a high research priority. Resolution of the potential protective roles of specific antioxidants and other constituents of fruits and vegetables deserves major attention. Mechanistic studies of carcinogenesis indicate an important role of endogenous oxidative damage to DNA that is balanced by elaborate defense and repair processes. Also key is the rate of cell division, which is influenced by hormones, growth, cytotoxicity, and inflammation, as this determines the probability of converting DNA lesions to mutations. These mechanisms may underlie many epidemiologic observations.
Roadmap for Accelerated Domestication of an Emerging Perennial Grain Crop (2020)

Shifting the life cycle of grain crops from annual to perennial would usher in a new era of agriculture that is more environmentally friendly, resilient to climate change, and capable of soil carbon sequestration. Despite decades of work, transforming the annual grain crop wheat (Triticum aestivum) into a perennial has yet to be realized. Direct domestication of wild perennial grass relatives of wheat, such as Thinopyrum intermedium, is an alternative approach. Here we highlight protein coding sequences in the recently released T. intermedium genome sequence that may be orthologous to domestication genes identified in annual grain crops. Their presence suggests a roadmap for the accelerated domestication of this plant using new breeding technologies.