gebhart/patrepeval huggingface dataset:
Wide-band analog frequency modulation of optic signals using indirect techniques (1991)

The wideband frequency modulation (FM) of an optical carrier by a radio frequency (RF) or microwave signal can be accomplished independent of laser type when indirect modulation is employed. Indirect modulators exploit the integral relation of phase to frequency so that phase modulators can be used to impress frequency modulation on an optical carrier. The use of integrated optics phase modulators, which are highly linear, enables the generation of optical wideband FM signals with very low intermodulation distortion. This modulator can be used as part of an optical wideband FM link for RF and microwave signals. Experimental results from the test of an indirect frequency modulator for an optical carrier are discussed.
Capacitively‐loaded CPW shunt stub notch filters (2003)

Abstract This paper describes optimal coplanar waveguide (CPW) 2 nd harmonic notch filters that utilize metal‐insulator‐metal (MIM) capacitors at each discontinuity, eliminating the need for conventional air‐bridges and significantly reducing the filter footprint. The circuits were fabricated on a high resistivity, 400 μm‐thick silicon substrate. Theoretical and experimental data for 42 GHz notch filters employing straight and bent shunt stubs are presented. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 36: 292–295, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10745
Gibberellins Are Not Required for Normal Stem Growth in <i>Arabidopsis thaliana</i> in the Absence of GAI and RGA (2001)

The growth of Arabidopsis thaliana is quantitatively regulated by the phytohormone gibberellin (GA) via two closely related nuclear GA-signaling components, GAI and RGA. Here we test the hypothesis that GAI and RGA function as "GA-derepressible repressors" of plant growth. One prediction of this hypothesis is that plants lacking GAI and RGA do not require GA for normal stem growth. Analysis of GA-deficient mutants lacking GAI and RGA confirms this prediction and suggests that in the absence of GAI and RGA, "growth" rather than "no growth" is the default state of plant stems. The function of the GA-signaling system is thus to act as a control system regulating the amount of this growth. We also demonstrate that the GA dose dependency of hypocotyl elongation is altered in mutants lacking GAI and RGA and propose that increments in GAI/RGA repressor function can explain the quantitative nature of GA responses.
Catalytic multi-stage liquefaction of coal. Tenth quarterly report, January 1--March 31, 1995 (1995)

The overall objective of this program is to produce liquid fuels from coal by direct liquefaction at a cost that is competitive with conventional fuels. Specifically, this continuous bench-scale program contains provisions to examine new ideas in areas such as: low temperature pretreatments, more effective catalysts, on-line hydrotreating, new coal feedstocks, other hydrogen sources, more concentrated coal feeds and other highly responsive process improvements while assessing the design and economics of the bench-scale results. This report describes the following: (1) laboratory support for bench run CMSL-09, (2) the laboratory-scale efforts for development of suitable catalysts for hydrocracking/depolymerization of waste plastics, (3) analysis of TBP (true boiling point) fractions of distillates from CMSL-08, and (4) objectives and run-plan for bench run CMSL-09.
Electroacoustic transducer with active dome (1984)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Hugues Facoetti, Phillippe Menoret, François Micheron, Patrick Petit, Pierre Ravinet; Electroacoustic transducer with active dome. J. Acoust. Soc. Am. 1 October 1984; 76 (4): 1287. https://doi.org/10.1121/1.391333 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Three-dimensional structural and angiographic evaluation of foveal ischemia in diabetic retinopathy: method and validation (2019)

Optical coherence tomography angiography (OCTA) allows us to noninvasively investigate foveal ischemia, a key feature of diabetic retinopathy (DR). However, the sizes of the foveal avascular zone (FAZ) have a significant variation in normal population, preventing the objective assessment of pathological enlargement of FAZ due to capillary dropout. Based on the relationship between FAZ and ganglion cell complex (GCC) thickness in normal eyes, we defined a theoretical baseline FAZ (tbFAZ) on structural OCT and measured 2D and 3D vessel density in its vicinity on the simultaneously acquired OCTA in normal and diabetic eyes. We found that the structure-based tbFAZ was a reliable reference to identify foveal ischemia and that the 3D vessel density demonstrated ischemia more effectively than the 2D method. The proposed 3D para-FAZ vessel density correlates well with DR severity and potentially is a useful diagnostic biomarker, especially in the early stages of DR.
Enhanced Safety Profiles of the Telomerase-Specific Replication-Competent Adenovirus by Incorporation of Normal Cell-Specific microRNA-Targeted Sequences (2011)

This study showed that oncolytic Ads containing the sequences complementary to normal cell-specific miRNAs showed significantly improved safety profiles without altering tumor cell lysis activity.
2-<i>μ</i>m fiber laser sources for sensing (2013)

2-μm fiber lasers have become a research topic with an increased emphasis due to a variety of applications including eye-safe LIDAR, spectroscopy, remote sensing, and mid-infrared (mid-IR) frequency generation. We review our latest development on various 2-μm fiber laser sources, including single-frequency fiber lasers, Q-switched fiber lasers, mode-locked fiber lasers, and mid-IR supercontinuum fiber sources. All these fiber laser sources are based on thulium and holmium ions using our proprietary glass fiber technology. Potential applications of these fiber laser sources for sensing are also briefly discussed.
HierarchyScan: a hierarchical similarity search algorithm for databases of long sequences (2002)

We present a hierarchical algorithm, HierarchyScan, that efficiently locates one-dimensional subsequences within a collection of sequences of arbitrary length. The subsequences identified by HierarchyScan match a given template pattern in a scale- and phase-independent fashion. The idea is to perform correlation between the stored sequences and the template in the transformed domain hierarchically. Only those subsequences whose maximum correlation value is higher than a predefined threshold will be selected. The performance of this approach is compared to the sequential scanning and an order-of-magnitude speedup is observed.
Analysis of controlled Rabi flopping in a double rephasing photon echo scheme for quantum memories (2016)

A double rephasing photon echo is analyzed for inversion-free photon echo-based quantum memories using controlled Rabi flopping, where the Rabi flopping is used for phase control of atom coherence. Unlike the rephasing-caused pi-phase shift in a single rephasing scheme, the control Rabi flopping between the excited state and an auxiliary third state induces coherence inversion. Thus, the absorptive photon echo in a double rephasing scheme can be manipulated to be emissive via the controlled Rabi flopping. Here we present a quantum coherence control of atom phases in a double rephasing photon echo scheme for emissive photon echoes for quantum memory applications.
O4‐04‐03: Molecular Mechanism of Tau Spread and Tau Sites to Target for Immunotherapy (2016)

Neurofibrillary pathology composed of abnormally hyperphosphorylated tau (P-tau) is a hallmark of Alzheimer disease (AD) and other tauopathies. Density of tau pathology directly correlates with the degree of dementia and is thus a major therapeutic target for diseases characterized by this lesion. Oligomeric P-tau isolated from AD brains was found to sequester normal tau in a prion-like fashion. Mouse monoclonal antibodies 43D to tau6-18 and 77E9 to tau184-195 were employed to immunize adult 3xTg-AD mice that overexpress human APPSWE and P301L tau along with human presenilin M146V knock-in, and both tau and Aβ pathologies and cognitive performance were studied in these animals. Each animal received intravenously through the tail vein 15 μg IgG (43D, 77E9 or as a control, normal mouse IgG) per injection per week for six weeks. AD P-tau was found to sequester normal tau in a prion-like, non-saturable manner and result in bundles of filaments. While both 43D and 77E9 markedly reduced tau pathology and showed a trend to reduce Aβ pathology, the former antibody was found to be far more effective in rescuing cognitive impairment as determined by Morris water maze, novel object recognition and novel object location tasks. (1) Spread of tau pathology involves the templating of normal tau by AD P-tau in a prion like manner; and (2) the success of tau immunotherapy could depend on the site targeted which does not have to be any phosphorylation site.
Temporal Dissipative Solitons in a Microresonator Driven by Optical Pulses (2017)

A nonlinear optical microresonator is driven by picosecond laser pulses resulting in formation of temporal dissipative solitons. These femtosecond solitons are stable and generated at a fraction of the power required in continuous-wave driven system.
A soft computing approach to fuzzy sky-hook control of semiactive suspension (2003)

This paper describes a soft computing approach to control a semiactive sky-hook suspension system. The fuzzy controller has been optimized by means of a genetic algorithm and implemented using a dedicated hardware device. After a preliminary study on a quarter car, a seven degree-of-freedom (7-DOF) model was implemented and used for controller simulation and optimization. The proposed control system takes the vehicle heave into account, improving the opposing requirements of comfort and drivability. The following conditions were optimized: drivability over random test roads, sine-wave holes, and sleeper-plates at different speeds. Fuzzy control makes it possible to change the characteristic parameters of the sky-hook suspension in an optimal way according to the different road conditions. The number of fuzzy controller inputs is kept as small as possible, avoiding the use of expensive sensors that increase the overall cost of the system. The proposed system is also easily applicable to existing commercial suspension systems. In addition to the comfort features, the fuzzy controller allows a reduction in load fluctuation, abnormal behavior and tire consumption.
An endogenous peptide signal in <i>Arabidopsis</i> activates components of the innate immune response (2006)

Innate immunity is initiated in animals and plants through the recognition of a variety of pathogen-associated molecules that in animals are called pathogen-associated molecular patterns and in plants are called elicitors. Some plant pathogen-derived elicitors have been identified as peptides, but peptide elicitors derived from the plant itself that activate defensive genes against pathogens have not been previously identified. Here, we report the isolation and characterization of a 23-aa peptide from Arabidopsis, called AtPep1, which activates transcription of the defensive gene defensin (PDF1.2) and activates the synthesis of H(2)O(2), both being components of the innate immune response. The peptide is derived from a 92-aa precursor encoded within a small gene that is inducible by wounding, methyl jasmonate, and ethylene. Constitutive expression of the AtPep1 precursor gene PROPEP1 in transgenic Arabidopsis plants causes a constitutive transcription of PDF1.2. When grown in soil, the transgenic plants exhibited an increased root development compared with WT plants and an enhanced resistance toward the root pathogen Pythium irregulare. Six paralogs of PROPEP1 are present in Arabidopsis, and orthologs have been identified in species of several agriculturally important plant families, where they are of interest for their possible use in crop improvement.
Locality-aware fountain codes for massive distributed storage systems (2015)

Low repair locality of a distributed storage code has been shown to reduce strain on storage node input-output (I/O) resources during node repair operations after a failure. In this paper, we consider the use of Fountain codes for distributed storage systems and aim to understand the relationship between repair locality and code parameters for a systematic Fountain code. While the information-theoretic trade-off between repair locality and storage overhead has been understood and characterized, the challenge of choosing a locality value that satisfies multiple storage system design metrics is yet to be resolved. We approach this problem by deriving an expression for the probability distribution of repair locality in terms of the rateless code degree distribution coefficients and suggest that factoring this relationship into the code design process enables the design of rateless codes better adjusted to the needs of a massive distributed storage system.
To waffinity and beyond: a scalable architecture for incremental parallelization of file system code (2016)

In order to achieve higher I/O throughput and better overall system performance, it is necessary for commercial storage systems to fully exploit the increasing core counts on modern systems. At the same time, legacy systems with millions of lines of code cannot simply be rewritten for improved scalability. In this paper, we describe the evolution of the multiprocessor software architecture (MP model) employed by the Netapp® Data ONTAP® WAFL® file system as a case study in incrementally scaling a production storage system.The initial model is based on small-scale data partitioning, whereby user-file reads and writes to disjoint file regions are parallelized. This model is then extended with hierarchical data partitioning to manage concurrent accesses to important file system objects, thus benefiting additional workloads. Finally, we discuss a fine-grained lock-based MP model within the existing data-partitioned architecture to support workloads where data accesses do not map neatly to the predefined partitions. In these data partitioning and lock-based MP models, we have facilitated incremental advances in parallelism without a large-scale code rewrite, a major advantage in the multi-million line WAFL codebase. Our results show that we are able to increase CPU utilization by as much as 104% on a 20-core system, resulting in throughput gains of up to 130%. These results demonstrate the success of the proposed MP models in delivering scalable performance while balancing time-to-market requirements. The models presented can also inform scalable system redesign in other domains.
Real‐time color B‐scan ultrasonography (1975)

The development and early clinical results of a real-time color B-scan ultrasonoscope are described. This instrument uses color to display detailed echo amplitude information more quantitatively than is possible with gray scale. With real time, dynamic changes are seen during the examination. Conversion of the amplitude information into binary coded decimal code permits separation into ten color steps and also eliminates "blooming" of the cathode ray tube, as seen in black and white. Integrated circuitry is used, providing a portable, relatively inexpensive unit. Early clinical work in ophthalmology is illustrated.
Patient decision-making of CGM sensor driven insulin therapies in type 1 diabetes: In silico assessment (2015)

In type 1 diabetes (T1D) therapy, continuous glucose monitoring (CGM) sensors, which provide glucose concentration in the subcutis every 1-5 min for 7 consecutive days, should allow in principle a more efficient insulin dosing than that based on the conventional 3-4 self-monitoring of blood glucose (SMBG) measurements per day. However, CGM, at variance with SMBG, is still not approved for insulin dosing in T1D management because regulatory agencies, e.g. FDA, are looking for more factual evidence on its safety. An in silico assessment of SMBG- vs CGM-driven insulin therapy can be a first step. Here we present a simulation model of T1D patient decision-making obtained by interconnecting models of glucose-insulin dynamics, SMBG and CGM measurement errors, carbohydrates-counting errors, insulin boluses time variability and forgetfulness, and subcutaneous insulin pump delivery. Inter- and intra- patient variability of model parameters are considered. The T1D patient decision-making model allows to run realistic multi-day simulations scenarios in a population of virtual subjects. We present the first results of simulations run in 20 virtual subjects over a 7-day period, which demonstrates that additional information brought by CGM (trend and hypo/hyperglycemic warnings) with respect to SMBG produces a statistically significant increment (about of 9%) of time spent by the patient in the euglycemic range (70-180 mg/dl).
Implementation of electrochemical sensors in arsenic-contaminated areas of West Bengal in India toward rapid and point-of-use detection of arsenic in drinking water (2014)

The difficulty of detecting small quantities of arsenic in water currently threatens the health of millions of people worldwide, as long-term exposure to arsenic has been associated with both cancerous and noncancerous health risks. Existing technologies make it possible to very accurately quantify arsenic levels in water; however the expense, extensive training, and off-site analysis required by these methods impede wide scale-use. Electrochemical detection offers many advantages, such as portability, minimal use of instrumentation, and ready integration with electronics. Toward a solution to water quality interventions, we have demonstrated an affordable and point-of-use platform capable of detecting trace amounts of arsenic in groundwater samples. Our electrochemical sensor utilizes a three-electrode system with carbon, silver, and silver/silver electrodes integrated with a handheld electrochemical analyzer. We employed our sensor to investigate arsenic concentration in drinking water on-site in the arsenic affected areas of the North 24 Parganas district in West Bengal, India. 38 samples were collected from shallow, midrange, and deep wells. A small water sample from each well was applied to the electrodes and the current response was quickly captured, returning quantitative results to the user, which alleviates the lag times and imprecise colorimetric assays that encumber current arsenic detection systems.
Reduction of residual stress in extreme ultraviolet Mo/Si multilayer mirrors with postdeposition thermal treatments (2001)

The as-deposited stress of typical high-reflectance extreme ultraviolet (EUV) Mo/Si multilayer mirrors is measured to be approximately ?410±10 MPa (compressive). These multilayers are deposited with dc magnetron sputtering and have near-normal incidence (5 deg) reflectances of 67.2±0.1% around 13.2 nm. The effect of both slow and rapid thermal treatments on multilayer stress and reflectance is measured. For both approaches, the stress of these multilayers is reduced quasi-linearly with the annealing temperature. Using the slow thermal anneal approach, it is possible to reduce the stress from ?410 MPa to zero by heating the sample to ~275°C with a corresponding reflectance loss of ~3.5% (absolute). If preserving the reflectance is critical, we show that heating the sample to ~220°C reduces the stress by 85% from ?407 to -63 MPa with a reflectance loss of only ~1.5% (absolute). It therefore appears possible to ‘‘tune’’ the stress of EUV Mo/Si multilayer mirrors with this postdeposition annealing technique and predict the loss in reflectance for any given desired final stress. Moreover, it seems that the relationship between the reflectance loss and the stress change does not depend on the type of thermal treatment, i.e., it is the same for both the slow and rapid thermal annealing techniques.
Synthetic genes for glycoprotein design and the elucidation of hydroxyproline- <i>O</i> -glycosylation codes (1999)

Design of hydroxyproline (Hyp)-rich glycoproteins (HRGPs) offers an approach for the structural and functional analysis of these wall components, which are broadly implicated in plant growth and development. HRGPs consist of multiple small repetitive "glycomodules" extensively O-glycosylated through the Hyp residues. The patterns of Hyp-O-glycosylation are putatively coded by the primary sequence as described by the Hyp contiguity hypothesis, which predicts contiguous Hyp residues to be attachment sites of small arabinooligosaccharides (1-5 Ara residues/Hyp); while clustered, noncontiguous Hyp residues are sites of arabinogalactan polysaccharide attachment. As a test, we designed two simple HRGPs as fusion proteins with green fluorescent protein. The first was a repetitive Ser-Hyp motif that encoded only clustered noncontiguous Hyp residues, predicted polysaccharide addition sites. The resulting glycoprotein had arabinogalactan polysaccharide O-linked to all Hyp residues. The second construct, based on the consensus sequence of a gum arabic HRGP, contained both arabinogalactan and arabinooligosaccharide addition sites and, as predicted, gave a product that contained both saccharide types. These results identify an O-glycosylation code of plants.
<title>Developments In Fabrication Of Binary Optical Elements</title> (1983)

We have produced highly efficient binary diffraction gratings -- 94% first order diffraction efficiency measured in the infrared (10.6 μm) on straight binary gratings and on binary holographic off-axis lenses. The observed point-spread functions of these lenses (F/10, f = 25 cm) were limited only by diffraction. To fabricate gratings we adapted IC production techniques. Our work brings together three independent developments: (1) theories on binary diffraction gratings operating in the EM domain, (2) large-scale integration (LSI) advances in pattern generation and substrate depositions, and (3) improvements in reactive ion-beam etching techniques.
Chemical Mass Production of Graphene Nanoplatelets in ∼100% Yield (2015)

Successful application of graphene is hampered by the lack of cost-effective methods for its production. Here, we demonstrate a method of mass production of graphene nanoplatelets (GNPs) by exfoliation of flake graphite in the tricomponent system made by a combination of ammonium persulfate ((NH4)2S2O8), concentrated sulfuric acid, and fuming sulfuric acid. The resulting GNPs are tens of microns in diameter and 10-35 nm in thickness. When in the liquid phase of the tricomponent media, graphite completely loses its interlayer registry. This provides a ∼100% yield of GNPs from graphite in 3-4 h at room temperature or in 10 min at 120 °C.
Scattered PET data for attenuation‐map reconstruction in PET/MRI (2014)

Scattered coincidences provide information to complement existing PET attenuation-correction approaches such as MLAA. The proposed scatter-to-attenuation back-projection and reconstruction may constitute a missing piece for resolving ambiguities in the simultaneous reconstruction of activity and attenuation, and improving the quality of μ-maps reconstructed from PET emission data.