gebhart/patrepeval huggingface dataset:
Physical dissociation of the TCR-CD3 complex accompanies receptor ligation. (1995)

Recent studies indicate that there may be functional uncoupling of the TCR-CD3 complex and suggest that the TCR-CD3 complex is composed of two parallel signal-transducing units, one made of gamma delta epsilon chains and the other of zeta chains. To elucidate the molecular mechanisms that may explain the functional uncoupling of TCR and CD3, we have analyzed their expression by using flow cytometry as well as immunochemical means both before and after stimulation with anti-TCR-beta, anti-CD3 epsilon, anti-CD2, staphylococcal enterotoxin B, and ionomycin. We present evidence that TCR physically dissociates from CD3 after stimulation of the TCR-CD3 complex. Stimulation with anti-CD3 resulted in down-modulation of TCR within 45 min whereas CD3 epsilon was still expressed on the cell surface as detected by flow cytometry. However, the cell surface expression of TCR and CD3 was not affected when cells were stimulated with anti-TCR-beta under the same conditions. In the case of anti-CD3 treatment of T cells, the TCR down-modulation appeared to be due to the internalization of TCR, as determined by immunoelectron microscopy. Immunochemical analysis of cells after stimulation with either anti-TCR or anti-CD3 mAbs revealed that the overall protein levels of TCR and CD3 were similar. More interestingly, the dissociation of the TCR-CD3 complex was observed with both treatments and occurred in a manner that the TCR and the associated TCR-zeta chain dissociated as a unit from CD3. These results provide the first report of physical dissociation of TCR and CD3 after stimulation through the TCR-CD3 complex. The results also suggest that the signal transduction pathway triggered by TCR may differ from that induced by CD3.
CRANIUM: Device for Improving Crane Productivity and Safety (1993)

Cranes are the most important pieces of equipment on many construction sites. While technological advances have been made in crane hardware, the communication system used to coordinate the crane operator's actions with other craftsmen has not changed in decades. Crane operators frequently cannot see the loads they are moving, so they rely on hand signals relayed among craftsmen. This paper introduces the CRANIUM, a video system designed to improve productivity and safety of crane operations by improving communications. A video camera mounted on the crane boom transmits an image to a television monitor in the crane cab. The operator has a real‐time picture of the loads and craftsmen which might otherwise be out of direct line of sight. A full‐scale fully‐operational prototype CRANIUM was designed, fabricated, and extensively tested in the field. Experimental results show that for moderate and high precision lifts, productivity can be increased 16–21%. Crane safety is also improved.
Brexit: : Mineral companies in "wait and see" mode (2016)

We've no idea [what is going to happen], one major UK-based mineral importer told IM, noting that whatever happens [it] will take two and a half years to be determined; that's a lot of water to flow under the bridge.

The main effect we see so far is on sterling, said [Hunter Hillcoat]. The weaker pound could make some UK-based companies look more attractive as US dollar-based valuations are translated into sterling-based valuations.

We are concerned because UK authorities haven't been supportive of manufacturing in the country, a UK-based market observer told IM. When future trade agreements are signed, they will be designed to benefit the more important sectors first, such as services and finance. These are [considered] more important than manufacturing. Ceramics will have a low priority.
Netarsudil Ophthalmic Solution (2021)

Netarsudil is a medication used in the treatment and management of glaucoma and ocular hypertension. Netarsudil is classified as a rho-kinase inhibitor. Primary open-angle glaucoma is characterized by progressive and irreversible optic neuropathy with a loss of optic nerve fibers. In patients with glaucoma, visual field loss can be minimized with accurate treatment regimens, regular follow-up, and enhanced patient compliance. This activity reviews the indications, contraindications, adverse events, and other key elements of netarsudil therapy for clinical management of glaucoma and ocular hypertension pertinent to interprofessional team members.
Runt-Related Transcription Factor 1 Regulates LPS-Induced Acute Lung Injury via NF-κB Signaling (2017)

Runt-related transcription factor 1 (RUNX1), a transcription factor expressed in multiple organs, plays important roles in embryonic development and hematopoiesis. Although RUNX1 is highly expressed in pulmonary tissues, its roles in lung function and homeostasis are unknown. We sought to assess the role of RUNX1 in lung development and inflammation after LPS challenge. Expression of RUNX1 was assessed in the developing and postnatal lung. RUNX1 was conditionally deleted in pulmonary epithelial cells. Pulmonary maturation was evaluated in the developing and postnatal lung, and lung inflammation was investigated in adult mice after LPS challenge. Interactions between RUNX1 and inflammatory signaling via NF-κB-IkB kinase β were assessed in vitro. RUNX1 was expressed in both mesenchymal and epithelial compartments of the developing and postnatal lung. The RUNX1 gene was efficiently deleted from respiratory epithelial cells producing Runx1<sup>∆/∆</sup> mice. Although lung maturation was delayed, Runx1<sup>∆/∆</sup> mice survived postnatally and subsequent growth and maturation of the lung proceeded normally. Increased respiratory distress, inflammation, and proinflammatory cytokines were observed in the Runx1-deleted mice after pulmonary LPS exposure. RUNX1 deletion was associated with the activation of NF-κB in respiratory epithelial cells. RUNX1 was required for the suppression of NF-κB signaling pathway via inhibition of IkB kinase β in in vitro studies. RUNX1 plays a critical role in the lung inflammation after LPS-induced injury.
Corrosion Inhibition of Mild Steel by Cationic and Anionic Polymers in Cooling Water System (1992)

The behavior of corrosion inhibition of mild steel by various cationic and anionic polymers, that is, polyethyleneimine (PEI), its derivative (PEID), polyarylamine (PAAm) and polydicyanodiamide derivative (PDCDA) as cationic polymers and polymaleic acid derivative (PMAD), polyacrylic acid derivative (PAAD) and polyacrylic acid (PAA) as anionic polymers, was investigated by corrosion tests and physicochemical measurements. Testing was done in two pseudoconcentrated solutions with low (LC) and high (HC) concentrations of ionic species like Ca2+ and Cl−. The cationic polymers lacked inhibition ability, while the anionic polymers had a more effective inhibition ability. The anionic polymers had a potential to act as corrosion inhibitors of an adsorption‐type in LC solution and as both corrosion inhibitors and scale inhibitors of calcium carbonate . In LC solution, the inhibition efficiency (η) value of anionic polymers was dependent on number‐average molecular weight , content of carboxylic group (‒COOH), and concentration of ‒COOH. In particular, the anionic polymers as inhibitors had an effective range of (103 order). In HC solution, the degree of corrosion of steel was influenced by concentrations of both anionic polymers and solution components such as Ca ion ; the anionic polymers were competitively adsorbed with Ca ion on the steel.
Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy. (1999)

HGFR is expressed in cultured RPE cells, in the RPE monolayer in human donor eyes, and in epiretinal membranes obtained from patients with PVR. Furthermore, HGF is a potent chemoattractant for cultured human RPE cells. These observations suggest a role for HGF and HGFR in normal function of RPE cells and in RPE-related disease such as PVR.
A Randomized Dose-Escalation Study of the Safety and Anti-Inflammatory Activity of the p38 Mitogen-Activated Protein Kinase Inhibitor Dilmapimod in Severe Trauma Subjects at Risk for Acute Respiratory Distress Syndrome (2015)

The novel p38 mitogen-activated protein kinase inhibitor dilmapimod appears well tolerated and may merit further evaluation for prevention of acute respiratory distress syndrome and other organ injury in larger clinical trials. Furthermore, results of this early-phase trial may aid in design of future studies aimed at prevention of acute respiratory distress syndrome and other organ injury.
Optically driven fluid flow along arbitrary microscale patterns using thermoviscous expansion (2008)

We show how fluid can be moved by a laser scanning microscope. Selected parts of a fluid film are pumped along the path of a moving warm spot which is generated by the repetitive motion of an infrared laser focus. With this technique, we remotely drive arbitrary two-dimensional fluid flow patterns with a resolution of 2μm. Pump speeds of 150μm∕s are reached in water with a maximal temperature increase in the local spot of 10K. Various experiments confirm that the fluid motion results from the dynamic thermal expansion in a gradient of viscosity. The viscosity in the spot is reduced by its enhanced temperature. This leads to a broken symmetry between thermal expansion and thermal contraction in the front and the wake of the spot. As result the fluid moves opposite to the spot direction due to both the asymmetric thermal expansion in the spot front and the asymmetric thermal contraction in its wake. We derive an analytical expression for the fluid speed from the Navier–Stokes equations. Its predictions are experimentally confirmed without fitting parameters under a number of different conditions. In water, this nonlinearity leads to a fluid step of &lt;100nm for each passage of the spot. Since the spot movement can be repeated in the kilohertz regime, fluid speeds can exceed 100μm∕s. Using this technique, we pump nanoparticles over millimeters through a gel. An all-optical creation of a dilution series of DNA and biomolecules by aliquotation and mixing is demonstrated for fluids sandwiched between untreated and unstructured, disposable microscope cover slips. The shown optical remote control of fluid flow expands the microfluidic paradigm into previously inaccessible regimes of tiny volumes, closed flow paths, fast switching between flow patterns, and remote fluid control under extreme fluid conditions.
Lipolytic activity of Campylobacter pylori: effect of colloidal bismuth subcitrate (De-Nol) (1989)

Infection by Campylobacter pylori appears to play a major role in the etiology of gastric disease, but the nature of impairment evoked by this pathogen in gastric mucosal defense is not well understood. We present here evidence that the extracellular material elaborated by this microorganism exhibits lipolytic activity capable of gastric mucosal lipid degradation. The colonies of bacteria, cultured from antral mucosal biopsy specimens of patients undergoing endoscopy, were washed with saline, passed through a sterilization filter, and the filtrate was examined for lipase and phospholipase activities. By following the degradation of glycerol trioleate and dipalmitoyl phosphatidylcholine, we established the presence of lipase and phospholipase A enzymes. The major product of the triglyceride degradation was glycerol monooleate, while lysophosphatidylcholine resulted from the degradation of phosphatidylcholine. The lipolytic activity of C. pylori filtrate was inhibited by an antiulcer drug, De-Nol, which at 150 micrograms/ml caused a 21% reduction in lipase activity and a 60% reduction in the activity of phospholipase A. The results suggest that De-Nol is capable of preventing degradation of mucosal lipids by C. pylori lipases and, hence, helps to preserve the mucosal integrity.
Communication with Dynamically Fluctuating States of Light Polarization (2002)

The fast, irregular, fluctuations of the state of polarization of light output from an erbium doper fiber ring laser are used to communicate digital information. The experiments illustrate the application of a dynamical encoding and information recovery scheme that is robust to perturbations of the communication channel, a standard single mode fiber. A fiber-optic polarization analyzer was used to measure and visualize the polarization dynamics at nanosecond time scales on the Poincaré sphere.
Ineffective ventilation during conscious sedation due to chest wall rigidity after intravenous midazolam and fentanyl. (1991)

Chest wall rigidity has been reported after the administration of high-dose intravenous fentanyl. This case report supports the observation that low-dose intravenous fentanyl may also cause chest wall rigidity. The treatment of chest wall rigidity with naloxone or neuromuscular blocking agents is controversial. A discussion of the management of fentanyl-induced chest wall rigidity is presented.
Outage Constrained Robust Multigroup Multicast Beamforming for Multi-Beam Satellite Communication Systems (2019)

We investigate outage constrained robust multigroup multicast beamforming for multi-beam satellite communication systems with full frequency reuse. Based on a satellite downlink beam domain channel model with channel phase uncertainty taken into account, we first investigate robust multigroup multicast beamforming with the aim to maximize the worst-case outage signal-to-interference-plus-noise ratio under the outage and the per-beam power constraints. We then cast the outage constrained robust beamforming design into the convex optimization framework with some approximation techniques. Simulation results show that the proposed robust multigroup multicast beamformer can provide significant performance gains in terms of multicast rate and outage probability over the conventional approach.
Hafnium Trifluoromethanesulfonate (Hafnium Triflate) as a Highly Efficient Catalyst for Chemoselective Thioacetalization and Transthioacetalization of Carbonyl Compounds (2008)

A range of carbonyl compounds including aliphatic and aromatic aldehydes and ketones were converted to the corresponding thioacetals in high yields in the presence of a catalytic amount of hafnium trifluoromethanesulfonate (0.1 mol %, room temperature). The mild conditions tolerated various sensitive functional and protecting groups and were racemization-free when applied to alpha-aminoaldehydes. Transacetalization and chemoselective thioacetalization of aromatic aldehydes in the presence of aliphatic aldehydes and ketones were also documented.
A comprehensive experimental study and numerical modeling of parison formation in extrusion blow molding (2006)

Abstract Parison dimensions in extrusion blow molding are affected by two phenomena, swell due to stress relaxation and sag drawdown due to gravity. It is well established that the parison swell and sag are strongly dependent on the die geometry and the operating conditions. The availability of a modeling technique ensures a more accurate prediction of the entire blow molding process, as the proper prediction of the parison formation is the input for the remaining process phases. This study considers both the simulated and the experimental effects of the die geometry, the operating conditions, and the resin properties on the parison dimensions using high density polyethylene. Parison programming with a moving mandrel and the flow rate evolution in intermittent extrusion are also considered. The parison dimensions are measured experimentally by using the pinch‐off mold technique on two industrial scale machines. The finite element software BlowParison® developed at IMI is used to predict the parison formation, taking into account the swell, sag, and nonisothermal effects. The comparison between the predicted parison/part dimensions and the corresponding experimental data demonstrates the efficiency of numerical tools in the prediction of the final part thickness and weight distributions. POLYM. ENG. SCI., 47:1–13, 2007. © 2006 Society of Plastics Engineers
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector (2010)

Aberrant Hedgehog (Hh) pathway activation has been implicated in cancers of diverse tissues and organs, and the tumor growth-inhibiting effects of pathway antagonists in animal models have stimulated efforts to develop pathway antagonists for human therapeutic purposes. These efforts have focused largely on cyclopamine derivatives or other compounds that mimic cyclopamine action in binding to and antagonizing Smoothened, a membrane transductory component. We report here that arsenicals, in contrast, antagonize the Hh pathway by targeting Gli transcriptional effectors; in the short term, arsenic blocks Hh-induced ciliary accumulation of Gli2, the primary activator of Hh-dependent transcription, and with prolonged incubation arsenic reduces steady-state levels of Gli2. Arsenicals active in Hh pathway antagonism include arsenic trioxide (ATO), a curative agent in clinical use for acute promyelocytic leukemia (APL); in our studies, ATO inhibited growth of Hh pathway-driven medulloblastoma allografts derived from Ptch+/-p53-/- mice within a range of serum levels comparable to those achieved in treatment of human APL. Arsenic thus could be tested rapidly as a therapeutic agent in malignant diseases associated with Hh pathway activation and could be particularly useful in such diseases that are inherently resistant or have acquired resistance to cyclopamine mimics.
Detection of numerical chromosomal aberrations in paraffin‐embedded malignant pleural mesothelioma by non‐isotopic <i>in situ</i> hybridization (1995)

An in situ hybridization (ISH) study on paraffin sections of 13 malignant mesotheliomas was performed to detect numerical chromosomal aberrations with biotin-labelled DNA probes specific for the centromeric regions of chromosomes 1, 3, 6, 7, 11, and 17. All chromosomes contributed to numerical changes, which can be summarized as follows: first, a monosomy for chromosome 6 was found in one case; second, in five cases a trisomy for at least one chromosome was detected; and third, in seven cases a pentasomy or a higher polysomy was found for at least one chromosome. Although these data have to be confirmed on a larger group of patients, survival analysis of this group showed no significant difference between the first and second groups taken together and the third group. In this study no specific numerical chromosomal aberrations were identified. Nevertheless, numerical gains appear to be more frequent than has previously been shown by karyotype analysis.
가정간편식(HMR) 선택속성에 대한 소비자 신념과 구매편향 연구 (2017)

본 연구는 주관적 확률모형과 공분산모델을 통해 가정간편식(Home Meal Replacement; HMR) 제품 중에서 최근 급성장하고 있는 편의점도시락 시장을 대상으로 20대 소비자들의 도시락 제품 선택속성에 대한 신념과 구매의도 수준을 조사했다. 더불어 사전에 소비자가 가지고 있는 제품 선택속성에 대한 신념을 유지할 수 있는 방향으로 도시락 제품에 대한...
Newly Identified Mechanisms of Total Parenteral Nutrition Related Liver Injury (2014)

Total parenteral nutrition (TPN), a lifesaving therapy, involves providing nutrition by bypassing the gut. Unfortunately it is associated with significant complications including gut atrophy and parenteral nutrition associated liver disease (PNALD). PNALD includes steatosis, cholestasis, disrupted glucose metabolism, disrupted lipid metabolism, cirrhosis, and liver failure. The etiopathogenesis remains poorly defined; however, an altered enterohepatic circulation, disrupting nuclear receptor signaling, is emerging as a promising mechanism. Rodent models and our piglet TPN model have shown that, during regular feeding, bile acids activate farnesoid X receptor (FXR) in the gut and enhance fibroblast growth factor 19 (FGF19) level. FGF19 regulates bile acid, lipid, and glucose metabolism. We noted reduced FGF19 with TPN use and substantial improvement in FGF19, bilirubin, and metabolic profiles with the FXR agonist chenodeoxycholic acid (CDCA). Additionally, CDCA caused gut growth and enhanced expression of glucagon like peptides (GLPs). GLPs regulate gut trophic effects, insulin, glucose homeostasis, and hepatic steatosis. GLP secretion is regulated by the CDCA activated receptor TGR5. This leads to an important conclusion that, in addition to a disrupted FXR-FGF19 axis, a disrupted TGR5-GLP axis may contribute to TPN related pathologies. Thus modulators of FXR-FGF19 and the TGR5-GLP axis could help bring forward novel treatment strategies.
Evaluation of the Corrosion Caused by Elevator and Spider Marks on C.R.A.-Pipe Comparing Conventional Inserts and a New Gripping System (1996)

Abstract Under a corrosive downhole environment, the completion of a well might be damaged if no precautions are taken. Pipe made of corrosion resistant alloys (C.R.A.) is used to minimize corrosion. An analysis of various corrosion mechanisms shows that the surface integrity is an important factor for corrosion prevention. Conventional spider and elevator inserts cause die marks that support corrosion. A new developed gripping system distributes the required load equally onto a large number of small peaks, minimizing the indentation of each single peak. Electrochemical investigations, the measurement of the surface indentations and microscopic analysis compare the effect of conventional dies and the new gripping system on C.R.A.-pipe. Using the new gripping system, the surface integrity is not damaged and the corrosion potential is virtually eliminated.
Efectos de la Violencia sobre el desarrollo psicosocial: Una reflexión para la práctica docente... (2022)

La violencia es una problemática presente en los diversos estamentos de la sociedad. En muchos casos, los actores sociales normalizan el uso de la violencia. Ante esta situación es importante identificar los efectos de esta problemática en el desarrollo psicosocial de niños y jóvenes. Y partiendo de estos hallazgos, reflexionar sobre la respuesta que está llamada a dar la escuela como agente socializador, promotor de una cultura de paz y de cooperación. Para esto, mediante una investigación de enfoque cualitativo de tipo documental, se identifican programas que contribuyan a dar una respuesta desde la prevención. Contar con programas basados en evidencias y que a su vez, han sido validados, contribuye al fomento de una práctica docente cimentada en los aportes de la ciencia y permite una solución eficaz a la problemática de la violencia.
Interactions between surfactants and polymers. I: HPMC (2007)

We have studied the interactions between hydroxypropylmethyl cellulose (HMPC) and the surface active substances sodium dodecylsulfate (SDS), cetyltrimethylammonium bromide (C16TAB), sodium cholate (SC0 and sodium taurocholate (STC) in solution. Cloud point (CP) measurements showed that the CP was lowered when surfactant was added at concentrations below the normal CMC, the effect being most pronounced for SDS and least for the bile salts. The effect could be enhanced with low concentrations of added salt. Experiments with ion-selective electrodes and conductdivity showed that the process was cooperative, and that small aggregates with low surface charge density were formed. The aggregates were highly hydrophobic as determined with fluorescence probe studies. The aggregation number of the SDS/HPMC aggregate was determined to be 30 with fluorescence quenching. The importance of the results from a pharmaceutical formulation point of view was emphasized.