gebhart/patrepeval huggingface dataset:
A phase I/II clinical trial of E6 T-cell receptor gene therapy for human papillomavirus (HPV)-associated epithelial cancers. (2017)

3009 Background: Engineered T-cell therapy has shown promise in B-cell malignancies and melanoma, but clinical investigation in epithelial cancers has been limited. Methods: We conducted a phase I/II clinical trial of T cells genetically engineered to express a T-cell receptor that targets an HLA-A*02:01-restricted epitope of E6 (E6 TCR T Cells) for patients with metastatic HPV-16+ carcinoma. The cell dose was escalated in cohorts of single patients (1 x 10 9 , 1 x 10 10 , and 1-2 x 10 11 cells). Patients received a nonmyeloablative conditioning regimen of cyclophosphamide and fludarabine, a single infusion of E6 TCR T Cells, and systemic high-dose aldesleukin. Results: Twelve patients were treated, 9 at the highest cell dose, plus one retreatment. The cancer types were 6 cervical, 4 anal, 1 oropharyngeal, and 1 vaginal. No dose-limiting toxicity, autoimmune adverse events, or cytokine storm were observed. Two patients with anal cancer treated at the highest cell dose experienced partial tumor responses lasting 6 and 3 months after treatment. The patient with a 6-month response had complete regression of one tumor and partial regression of two tumors that were resected upon progression; she has no evidence of disease 22 months after treatment. T-cell receptor gene transfer efficiency was 45 and 51% in the responding patients, and 47-76% (median 61%) in the non-responding patients. Responding patients showed robust levels of E6 TCR T cell memory (30 and 46% of circulating T cells 1-month after treatment). Non-responding patients showed wide-ranging levels of E6 TCR T cell memory (range 4-53%, median 29%). Expression of programmed cell death protein 1 (PD-1) by circulating E6 TCR T Cells 1-month after treatment was low in all patients ( < 5%). The patient with a 6-month response had 7% E6 TCR T Cells in a resected tumor 10 months after treatment, 25% of which expressed PD-1. A patient with no response had no detectable E6 TCR T Cells in a resected tumor 3 months after treatment. Conclusions: E6 TCR T-cell therapy was safe at doses up to 2 x 10 11 cells. Regression of metastatic HPV+ carcinoma occurred in two patients following treatment, suggesting that TCR T-cell therapy can mediate epithelial cancer regression. Clinical trial information: NCT02280811.
Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-Imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents (1986)

A series of N-[(1H-heteroaryl)alkyl]-1H-isoindole-1,3(2H)-diones were prepared as part of a continuing investigation into the biological properties of compounds that were both thromboxane synthetase inhibitors and potential antihypertensive agents. The most active thromboxane synthetase inhibition was found for the title imidazole derivatives wherein a hexyl or octyl chain separated the heterocyclic ends of the molecule (5,6) or with substitution on the isoindole portion of the molecule (18, 19, 21, 22, 25, 26). Compounds with shorter alkyl chain separations had good antihypertensive effects (1-5, 8-10, 19-22, 27-30). Butyl derivative 3 was chosen for further evaluation as a potential antihypertensive agent with thromboxane synthetase inhibitory properties.
Analysis of High-Frequency Modulation Response of Strongly Injection-Locked Cascaded Semiconductor Ring Lasers (2012)

A novel scheme for modulation bandwidth enhancement and tailoring is presented. This scheme involves a distributed Bragg reflector master laser monolithically integrated with two cascaded strongly injection-locked whistle-geometry semiconductor microring lasers. Enhanced high-speed performance of the novel scheme is confirmed through numerical modeling.
ChemInform Abstract: Syntheses of 22,23‐Dihydro‐1α,25‐dihydroxyvitamin D2 and Its 24R‐Epimer, New Vitamin D2 Derivatives. (1990)

ChemInformVolume 21, Issue 50 Natural Products ChemInform Abstract: Syntheses of 22,23-Dihydro-1α,25-dihydroxyvitamin D2 and Its 24R-Epimer, New Vitamin D2 Derivatives. M. TSUJI, M. TSUJI Res. Cent., Nisshin Flour Milling Co., Ltd., Iruma, Saitama 354Search for more papers by this authorS. YOKOYAMA, S. YOKOYAMA Res. Cent., Nisshin Flour Milling Co., Ltd., Iruma, Saitama 354Search for more papers by this authorY. TACHIBANA, Y. TACHIBANA Res. Cent., Nisshin Flour Milling Co., Ltd., Iruma, Saitama 354Search for more papers by this authorN. IKEKAWA, N. IKEKAWA Res. Cent., Nisshin Flour Milling Co., Ltd., Iruma, Saitama 354Search for more papers by this author M. TSUJI, M. TSUJI Res. Cent., Nisshin Flour Milling Co., Ltd., Iruma, Saitama 354Search for more papers by this authorS. YOKOYAMA, S. YOKOYAMA Res. Cent., Nisshin Flour Milling Co., Ltd., Iruma, Saitama 354Search for more papers by this authorY. TACHIBANA, Y. TACHIBANA Res. Cent., Nisshin Flour Milling Co., Ltd., Iruma, Saitama 354Search for more papers by this authorN. IKEKAWA, N. IKEKAWA Res. Cent., Nisshin Flour Milling Co., Ltd., Iruma, Saitama 354Search for more papers by this author First published: December 11, 1990 https://doi.org/10.1002/chin.199050332Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume21, Issue50December 11, 1990 RelatedInformation
OFDM Systems in the Presence of Phase Noise: Consequences and Solutions (2004)

We provide an exact analysis of orthogonal frequency-division multiplexing (OFDM) performance in the presence of phase noise. Unlike most methods which assume small phase noise, we examine the general case for any phase noise levels. After deriving a closed-form expression for the signal-to-noise-plus-interference ratio (SINR), we exhibit the effects of phase noise by precisely expressing the OFDM system performance as a function of its critical parameters. This helps in understanding the meaning of small phase noise and how it reflects on the proper parameters selection of a specific OFDM system. In order to combat phase noise, we also provide in this paper a general phase-noise suppression scheme, which, by analytical and numerical results, proves to be quite effective in practice.
Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and Pathways (2015)

Several studies have identified genes that are differentially expressed in atopic dermatitis (AD) compared to normal skin. However, there is also considerable variation in the list of differentially expressed genes (DEGs) reported by different groups and the exact cause of AD is still not fully understood. Using a rank-based approach, we analyzed gene expression data from five different microarray studies, comprising a total of 127 samples and more than 250,000 transcripts. A total of 89 AD gene expression signatures '89ADGES', including FLG gene, were identified to show dysregulation consistently across these studies. Using a Support Vector Machine, we showed that the '89ADGES' discriminates AD from normal skin with 98% predictive accuracy. Functional annotation of these genes implicated their roles in immune responses (e.g., betadefensin, microseminoprotein), keratinocyte differentiation/epidermal development (e.g., FLG, CORIN, AQP, LOR, KRT16), inflammation (e.g., IL37, IL27RA, CCL18) and lipid metabolism (e.g., AKR1B10, FAD7, FAR2). Subsequently, we validated a subset of signature genes using quantitative PCR in a mouse model. Using a bioinformatic approach, we identified keratinocyte pathway over-represented (P = <0.0006) among the 89 signature genes. Keratinocytes are known to play a major role in barrier function due to their location in the epidermis. Our result suggests that besides immune- mediated pathway, skin barrier pathways such as the keratinocyte differentiation pathway play a key role in AD pathogenesis. A better understanding of the role of keratinocytes in AD will be important for developing novel "barrier therapy" for this disease.
Adversarial Teacher-Student Learning for Unsupervised Domain Adaptation (2018)

The teacher-student (T/S) learning has been shown effective in unsupervised domain adaptation [1]. It is a form of transfer learning, not in terms of the transfer of recognition decisions, but the knowledge of posteriori probabilities in the source domain as evaluated by the teacher model. It learns to handle the speaker and environment variability inherent in and restricted to the speech signal in the target domain without proactively addressing the robustness to other likely conditions. Performance degradation may thus ensue. In this work, we advance T/S learning by proposing adversarial T/S learning to explicitly achieve condition-robust unsupervised domain adaptation. In this method, a student acoustic model and a condition classifier are jointly optimized to minimize the Kullback-Leibler divergence between the output distributions of the teacher and student models, and simultaneously, to min-maximize the condition classification loss. A condition-invariant deep feature is learned in the adapted student model through this procedure. We further propose multi-factorial adversarial T/S learning which suppresses condition variabilities caused by multiple factors simultaneously. Evaluated with the noisy CHiME-3 test set, the proposed methods achieve relative word error rate improvements of 44.60% and 5.38%, respectively, over a clean source model and a strong T/S learning baseline model.
Passively Q-switched Er^3+-doped fiber lasers using colloidal PbS quantum dot saturable absorber (2016)

We report on the demonstration of a passively Q-switched 1.55 µm fiber laser utilizing a colloidal PbS quantum dot (QD) thin film as a saturable absorber. Colloidal PbS QD films have several features that are advantageous in passively Q-switched fiber laser operation, including a large operation wavelength range, cost-effectiveness, and a low saturable absorption intensity. We conducted thorough material and optical studies to verify the advantages of PbS QDs in Q-switched laser operation and successfully generated 801 nJ pulses with a 24.2 kHz repetition rate. To the best of our knowledge, the developed Q-switched fiber laser is the first based on colloidal PbS QDs.
High-speed InP/InGaAsP/InGaAs avalanche photodiodes grown by chemical beam epitaxy (1988)

High-performance InP/InGaAsP/InGaAs avalanche photodiodes (APDs) grown by chemical beam epitaxy are described. These APDs exhibit low dark current (less than 50 nA at 90% of breakdown), good external quantum efficiency (greater than 90% at a wavelength of 1.3 mu m), and high avalanche gain ( approximately=40). In the low-gain regime, bandwidths as high as 8 GHz have been achieved. At higher gains, a gain-bandwidth-limited response is observed; the gain-bandwidth product is 70 GHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Tilted Interferometry Realizes Universal Quantum Computation in the Ising TQFT without Overpasses (2005)

We show how a universal gate set for topological quantum computation in the Ising TQFT, the non-Abelian sector of the putative effective field theory of the $ν=5/2$ fractional quantum Hall state, can be implemented. This implementation does not require overpasses or surgery, unlike the construction of Bravyi and Kitaev, which we take as a starting point. However, it requires measurements of the topological charge around time-like loops encircling moving quasiaparticles, which require the ability to perform `tilted' interferometry measurements.
Rapid Assay for Simultaneous Detection and Differentiation of Immunoglobulin G Antibodies to Human Immunodeficiency Virus Type 1 (HIV-1) Group M, HIV-1 Group O, and HIV-2 (1998)

A rapid immunodiagnostic test that detects and discriminates human immunodeficiency virus (HIV) infections on the basis of viral type, HIV type 1 (HIV-1) group M, HIV-1 group O, or HIV-2, was developed. The rapid assay for the detection of HIV (HIV rapid assay) was designed as an instrument-free chromatographic immunoassay that detects immunoglobulin G (IgG) antibodies to HIV. To assess the performance of the HIV rapid assay, 470 HIV-positive plasma samples were tested by PCR and/or Western blotting to confirm the genotype of the infecting virus. These samples were infected with strains that represented a wide variety of HIV strains including HIV-1 group M (subtypes A through G), HIV-1 group O, and HIV-2 (subtypes A and B). The results showed that the HIV genotype identity established by the rapid assay reliably (469 of 470 samples) correlates with the HIV genotype identity established by PCR or Western blotting. A total of 879 plasma samples were tested for IgG to HIV by a licensed enzyme immunoassay (EIA) (470 HIV-positive samples and 409 HIV-negative samples). When they were tested by the rapid assay, 469 samples were positive and 410 were negative (99.88% agreement). Twelve seroconversion panels were tested by both the rapid assay and a licensed EIA. For nine panels identical results were obtained by the two assays. For the remaining three panels, the rapid assay was positive one bleed later in comparison to the bleed at which the EIA was positive. One hundred three urine samples, including 93 urine samples from HIV-seropositive individuals and 10 urine samples from seronegative individuals, were tested by the rapid assay. Ninety-one of the ninety-three urine samples from HIV-seropositive individuals were found to be positive by the rapid assay. There were no false-positive results (98.05% agreement). Virus in all urine samples tested were typed as HIV-1 group M. These results suggest that a rapid assay based on the detection of IgG specific for selected transmembrane HIV antigens provides a simple and reliable test that is capable of distinguishing HIV infections on the basis of viral type.
A Height Constrained Adaptive Kalman Filtering Based on Climbing Motion Model for GNSS Positioning (2017)

In the past decades, short multipath effect is one of the most important error sources in global navigation satellite systems (GNSS) navigation, and seriously affects the positioning precision. Therefore, some algorithms based on traditional Kalman filtering (KF) have been proposed to overcome the short multipath effect, for example extended KF (EKF), adaptive KF (AKF) and constrained KF (CKF). However, height positioning accuracy of EKF and AKF is lower than that of horizontal. On the other hand, CKF requires additional height information from a barometer or location service system. To overcome the limitations of current algorithms, this paper first proposes an empirical multipath residual model after GNSS baseband processing, which shows that pseudo range error exhibits “rectangular” distribution or “shock” distribution. This paper also demonstrates that GNSS positioning error has the same distribution as the pseudo range error, and the height positioning error is higher than the horizontal positioning error in influence of short multipath effect. To improve the height positioning accuracy and suppress the short multipath effect, we propose a practical climbing motion model to constrain the height estimation in the AKF, which can effectively suppress short multipath effect and achieve an improved positioning result. Field tests illustrate that the proposed height constrained AKF (HCAKF) improves the height positioning accuracy by 85.1% over traditional EKF, 85.4% over AKF, and improves the total positioning accuracy by 56.9% over traditional EKF, 37.8% over AKF. Furthermore, the height estimate from HCAKF is smoother than those from traditional EKF and AKF.
Synthesis and characterization of new soluble polyimides derived from 2,2-bis[3,5-dimethyl-4-(4-aminophenoxy)phenyl]propane (1998)

A diamine monomer containing isopropylidene and methyl substituted arylene ether, 2,2-bis[3,5-dimethyl-4-(4-aminophenoxy)phenyl]propane (TBAPP), was prepared in two steps. The monomer was reacted with six different aromatic tetracarboxylic dianhydrides in N,N-dimethylacetamide (DMAc) to obtain the corresponding new polyimides via the poly(amic acid) precursors and thermal or chemical imidization. The poly(amic acid)s obtained had inherent viscosities ranging from 1.38–2.10 dL · g−1. All the poly(amic acid)s could be cast from DMAc solutions and thermally converted into transparent, flexible, and tough polyimide films. The polyimide films had a tensile strength in the range from 52–95 MPa, an elongation at break within a range of 4–8%, and a tensile modulus in the range from 1.60–2.09 GPa. All polyimides were amorphous. The polyimides derived from diamine TBAPP had excellent solubility in various solvents except for those derived from rigid dianhydrides such as pyromellitic dianhydride and 3,3′,4,4′-biphenyltetracarboxylic dianhydride. These polyimides showed glass transition temperatures between 249–293°C and decomposition temperature at 10% mass loss temperatures ranging from 460–485°C in nitrogen.
Automatic extraction of the pulmonary artery tree from multi-slice CT data (2005)

The purpose of this paper is to present an automated method for the extraction of the pulmonary vessel tree from multi-slice CT data. Furthermore we investigate a method for the separation of pulmonary arteries from veins. The vessel tree extraction is performed by a seed-point based front-propagation algorithm. This algorithm is based on a similar methodology as the bronchial tree segmentation and coronary artery tree extraction methods presented at earlier SPIE conferences. Our method for artery/vein separation is based upon the fact that the pulmonary artery tree accompanies the bronchial tree. For each extracted vessel segment, we evaluate a measure of "arterialness". This measure combines two components: a method for identifying candidate positions for a bronchus running in the vicinity of a given vessel on the one hand and a co-orientation measure for the vessel segment and bronchus candidates. The latter component rewards vessels running parallel to a nearby bronchus. The spatial orientation of vessel segments and bronchi is estimated by applying the structure tensor to the local gray-value neighbourhood. In our experiments we used multi slice CT datasets of the lung acquired by Philips IDT 16-slice, and Philips Brilliance 40-slice scanners. It can be shown that the proposed measure reduces the number of pulmonary veins falsely included into the arterial tree.
GestARLite: An On-Device Pointing Finger Based Gestural Interface for Smartphones and Video See-Through Head-Mounts (2019)

Hand gestures form an intuitive means of interaction in Mixed Reality (MR) applications. However, accurate gesture recognition can be achieved only through state-of-the-art deep learning models or with the use of expensive sensors. Despite the robustness of these deep learning models, they are generally computationally expensive and obtaining real-time performance on-device is still a challenge. To this end, we propose a novel lightweight hand gesture recognition framework that works in First Person View for wearable devices. The models are trained on a GPU machine and ported on an Android smartphone for its use with frugal wearable devices such as the Google Cardboard and VR Box. The proposed hand gesture recognition framework is driven by a cascade of state-of-the-art deep learning models: MobileNetV2 for hand localisation, our custom fingertip regression architecture followed by a Bi-LSTM model for gesture classification. We extensively evaluate the framework on our EgoGestAR dataset. The overall framework works in real-time on mobile devices and achieves a classification accuracy of 80% on EgoGestAR video dataset with an average latency of only 0.12 s.
Constrained feed technique for subarrays of largephased arrays (1998)

A technique is presented which combines the subarraying qualities of constrained dual transform beamforming sections and partial overlapping networks to produce arrays of contiguous subarrays. This approach is shown to facilitate wideband scanning or limited field of view coverage with a minimum number of controls and low sidelobes.
Antibody-Targeted Chemotherapy for the Treatment of Melanoma (2016)

Antibody-directed chemotherapy (ADC) offers an advantage over conventional chemotherapy because it provides antibody-directed targeting, with resultant improvement in therapeutic efficacy and reduced toxicity. Despite extensive research, with notable exceptions, broad clinical application of ADC remains elusive; major hurdles include the instability of antibody-chemotherapy linkers and reduced tumor toxicity of the chemotherapy when bound to the antibody. To address these challenges, we have developed a platform technology that utilizes the nab-paclitaxel formulation of paclitaxel, Abraxane, in which hydrophobic paclitaxel is suspended in 130-nm albumin nanoparticles and thus made water-soluble. We have developed a method to noncovalently coat the Abraxane nanoparticle with recombinant mAbs (anti-VEGF, bevacizumab) and guide Abraxane delivery into tumors in a preclinical model of human A375 melanoma. Here, we define the binding characteristics of bevacizumab and Abraxane, demonstrate that the chemotherapy agent retains its cytotoxic effect, while the antibody maintains the ability to bind its ligand when the two are present in a single nanoparticle (AB160), and show that the nanoparticle yields improved antitumor efficacy in a preclinical human melanoma xenograft model. Further data suggest that numerous therapeutic monoclonal IgG1 antibodies may be utilized in this platform, which has implications for many solid and hematologic malignancies. Cancer Res; 76(13); 3954-64. ©2016 AACR.
Structural Characterization of Novel Styrene−Butadiene Block Copolymers Containing Syndiotactic Styrene Homosequences (2002)

Samples of poly(syndiotactic styrene-co-butadiene) (sPS−B) have been prepared using methylalumoxane (MAO) activated CpTiCl3 under a range of experimental conditions. Copolymerization activities were low (24−36 kg mol-1 of cat. h-1) and nearly constant over the range of polymerization temperatures investigated (25−70 °C). Eight sPS−B samples were synthesized at 25 °C with styrene molar fractions (xs) covering a full range of compositions (xs = 0.15−0.92). The copolymer samples were characterized by solution and solid state 13C NMR spectroscopy, X-ray powder diffraction analysis, and thermal (DSC) analysis. The 13C NMR analysis of the copolymer microstructure suggests that the butadiene homosequences are primarily cis-1,4 and the styrene segments are syndiotactic. However, some 1,2- and trans-1,4-butadiene units are occasionally formed during the polymerization process. The 13C NMR resonances diagnostic of the monomer triads comprising styrene units (SSB, SBS, BBS, BSB, and SSS) were assigned and the average styrene block lengths (nS) calculated. Copolymer samples in which nS > 9 are crystalline due to the syndiotactic polystyrene segments detected in the δ-toluene clathrate form with melting points in the range 205−230 °C. Syndiotactic polystyrene segments with shorter styrene block lengths are amorphous and partially included in the poly(butadiene) rubber domains. TEM images of sample 13 (xS = 0.37, nS = 8.8) show the presence of small sPS fibers.