gebhart/patrepeval huggingface dataset:
Structural diversity in binary superlattices self-assembled from polymer-grafted nanocrystals (2015)

Multicomponent nanocrystal superlattices represent an interesting class of material that derives emergent properties from mesoscale structure, yet their programmability can be limited by the alkyl-chain-based ligands decorating the surfaces of the constituent nanocrystals. Polymeric ligands offer distinct advantages, as they allow for more precise tuning of the effective size and 'interaction softness' through changes to the polymer's molecular weight, chemical nature, architecture, persistence length and surrounding solvent. Here we show the formation of 10 different binary nanocrystal superlattices (BNSLs) with both two- and three-dimensional order through independent adjustment of the core size of spherical nanocrystals and the molecular weight of densely grafted polystyrene ligands. These polymer-brush-based ligands introduce new energetic contributions to the interparticle potential that stabilizes various BNSL phases across a range of length scales and interparticle spacings. Our study opens the door for nanocrystals to become modular elements in the design of functional particle brush solids with controlled nanoscale interfaces and mesostructures.
Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion. (1995)

Vinculin, a major constituent of focal adhesions and zonula adherens junctions, is thought to be involved in linking the microfilaments to areas of cell-substrate and cell-cell contacts. To test the role of vinculin in cell adhesion and motility, we used homologous recombination to generate F9 embryonal carcinoma and embryonic stem cell clones homozygous for a disrupted vinculin gene. When compared to wild-type cells, vinculin-mutant cells displayed a rounder morphology and a reduced ability to adhere and spread on plastic or fibronectin. Decreased adhesion of the mutant cells was associated with a reduction in lamellipodial extensions, as observed by time-lapse video microscopy. The locomotive activities of control F9 and the vinculin-null cells were compared in two assays. Loss of vinculin resulted in a 2.4-fold increase in cell motility. These results demonstrate an important role for vinculin in determining cell shape, adhesion, surface protrusive activity, and cell locomotion.
A New Transformer-Based Non-Isolated Topology Optimized for VRM Application (2006)

The duty cycle of conventional multi-phase buck converters becomes extremely small as the output voltage becomes lower and lower. This is a severe challenge with the switching frequency goes up. This paper introduces a non-isolated half bridge converter which can extend the duty cycle to a favorable range. Thus, the converter will have symmetrical dynamic response ability. The switching loss will reduce dramatically. The primary current is directly transferred to the output. The energy transferring is more effectively then that of conventional isolated half bridge converter. In addition, the voltage stress of the primary MOSFETs equals to the input voltage, which is much lower than that of non-isolated forward or push-pull topologies. A 12 V input, 0.8 V/30 A output, 500 kHz prototype was built to demonstrate the advantages
Conformational Dynamics of Calmodulin in Complex with the Calmodulin-Dependent Kinase Kinase α Calmodulin-Binding Domain (2006)

As the primary intracellular calcium sensor, calcium-saturated calmodulin (CaM) regulates numerous and diverse proteins. Several mechanisms, including tissue-specific expression, localization, and sequestration, work in concert to limit the total number of available targets of calmodulin within a cell. While the free energies of binding of calmodulin-binding domains of regulated proteins by CaM have been shown to be highly similar, they result from vastly different enthalpic and entropic contributions. Here, we report the backbone and side-chain methyl dynamics of calcium-activated calmodulin in complex with a peptide corresponding to the CaM-binding domain of calmodulin kinase kinase, along with the thermodynamic underpinnings of complex formation. The results show a considerable reduction in side-chain mobility throughout CaM upon binding the CaMKKalpha peptide, which is consistent with the enthalpically driven nature of the binding. Site-specific comparison to another kinase-derived peptide complex with similar thermodynamic values reveals significant differences in dynamics largely localized to the hydrophobic binding sites.
Rebaudiosides R and S, Minor Diterpene Glycosides from the Leaves of <i>Stevia rebaudiana</i> (2016)

Two new diterpene glycosides have been isolated from a commercial extract of the leaves of Stevia rebaudiana. Compound 1 was shown to be 13-[(2-O-β-d-glucopyranosyl-3-O-β-d-glucopyranosyl-β-d-xylopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-d-glucopyranosyl ester (rebaudioside R), while compound 2 was determined to be 13-[(2-O-α-d-glucopyranosyl-β-d-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid 2-O-α-l-rhamnopyranosyl-β-d-glucopyranosyl ester (rebaudioside S). Six additional known compounds were identified, dulcoside B, 13-[(2-O-β-d-xylopyranosyl-β-d-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-d-glucopyranosyl ester, eugenol diglucoside, rebaudioside G, 13-[(2-O-6-deoxy-β-d-glucopyranosyl-3-O-β-d-glucopyranosyl-β-d-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-d-glucopyranosyl ester, and rebaudioside D (3), respectively. The structures of 1 and 2 were determined based on comprehensive 1D and 2D NMR (COSY, HSQC, and HMBC) studies. A high-quality crystal of compound 3 allowed confirmation of its structure by X-ray diffraction.
Recent Progress in Modeling the Operation of Resistive Switching Memory Devices (2012)

Abstract not Available.
NMOS IC's for clock and data regeneration in gigabit-per-second optical-fiber receivers (1992)

The design and performance of two essential analog circuits in optical-fiber receivers is described. A time-interleaved decision circuit is capable of regenerating 35-mV nonreturn-to-zero (NRZ) data inputs to full logic levels at 1.1 Gb/s with 10/sup -11/ bit error rate (BER), and a phase-locked loop (PLL) extracts the clock from a 2/sup 23/ long pseudorandom sequence at 1.5 Gb/s with 13-ps r.m.s. jitter. The two circuits have been implemented as 1- mu m NMOS ICs, and in their core area dissipate 200 and 350 mW, respectively.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Desmond Egan : Universal Midlander (1988)

Egan's range — both in subject-matter and emotionally — is wide and he has developed a technique which perfectly complements it. He has refined that poetic fluidity of expression and that breadth of reference over a career which began with the publication in 1972 of Midland and which has continued through seven subsequent books of poetry to date. Egan's earlier poetry exhibits a strong sense of place, a feeling for the landscape of the Irish midlands where he grew-up. His lyricism gradually acquired a cutting, contemporary edge and his poetry became more directly engagé after Siege ! was published in 1976. Egan is very much a modernist in the Pound/William Carlos Williams tradition - though the example of modern American (and indeed European) writing is one which he has assimilated and integrated well into his own unique voice. His readiness to experiment with new forms, to invent new techniques, may partly derive from his interest in modern painting and music ; it certainly gives him a special place among Irish poets.
Learning to Rank with Query-level Semi-supervised Autoencoders (2017)

Learning to rank utilizes machine learning methods to solve ranking problems by constructing ranking models in a supervised way, which needs fixed-length feature vectors of documents as inputs, and outputs the ranking models learned by iteratively reducing the pre-defined ranking loss. The document features are always extracted based on classic textual statistics, and different features contribute differently to ranking performance. Given that well-defined features would contribute more to the retrieval performance, we investigate the usage of autoencoders to enrich the feature representations of documents. Autoencoders, as basic building blocks of deep neural networks, have been successfully used in many text mining tasks for generating effective features. To enrich the feature space for learning to rank, we introduce supervision into the loss functions of autoencoders. Specifically, we first train a linear ranking model on the training data, and then incorporate the learned weights into the reconstruction costs of an autoencoder. Meanwhile, we accumulate the costs of documents for a given query with query-level constraints for producing more useful features. We evaluate the effectiveness of our model on three LETOR datasets, and show that our model can generate effective document features to improve the retrieval performance.
Projeto de um Gateway para Automação Residencial (2016)

A Internet, e mais recentemente a Internet das Coisas (Internet of Things – IoT), tem mudado a forma com que as pessoas interagem com os dispositivos. Embora tenha havido muito avanço na conectividade de dispositivos eletrônicos de consumo, ainda se encontram em fase de transição para uma arquitetura completamente conectada. Aparelhos antigos sem qualquer forma de conexão ainda contam com uma sobrevida de alguns anos até que sejam completamente substituídos pelos aparelhos conectados. É possível encontrar hoje no mercado aparelhos muitas vezes denominados gateways para automação residencial, que se propõem a atuarem como controles universais. Para o presente trabalho foi desenvolvida uma versão preliminar de um dispositivo (gateway) que possa concentrar as tecnologias de transmissão de dados e controle de dispositivos domésticos e agir como uma ponte entre um smartphone e dispositivos eletroeletrônicos através de uma rede sem fio IEEE 802.11, podendo ser acessado de qualquer lugar por meio da conexão dessa rede à Internet. Através de interfaces de transmissão e recepção de sinais infravermelhos (infrared – IR) e em radiofrequência (RF) de 433 MHz é possível controlar aparelhos de entretenimento (TVs, Home Theaters, DVDs, etc.) e automação residencial (abridores de portão de garagem, interruptores e tomadas inteligentes).O dispositivo desenvolvido servirá como base para facilmente expandir suas capacidades e será uma plataforma sobre a qual podem ser testadas soluções para a Internet das Coisas.
Precipitation of amorphous SiO2 particles and their properties (2011)

The experimental conditions were optimized for the synthesis of amorphous SiO2 particles by the reaction of neutralization of sodium silicate solution with H2SO4 solution. Amorphous SiO2 particles were characterized by XRD, FT-IR, FE-SEM, EDS and microelectrophoresis. The amorphous peak was located at 2θ = 21.8º in the XRD pattern. Primary SiO2 particles were ~ 15 to ~ 30 nm in size and they aggregated into bigger particles. Amorphous SiO2 particles showed a specific surface area up to 130 m²g-1, dependent on the parameters of the precipitation process. The EDS spectrum of amorphous SiO2 particles did not show contamination with sulfate or other ions, which cannot be excluded in traces. pHzpc =1.7 was obtained by microelectrophoresis.
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells (2016)

(Cancer Cell 29, 214–228; February 8, 2016) During figure preparation for this article, the authors inadvertently duplicated representative flow plots within Figure 3A (gated plot on left and lower right plot) and within Figures 4A and 4B (CTRL, AML17 and 126OE, AML17). The authors regret this error and apologize for any confusion that it may have caused. These errors have now been corrected in the figures here and in the article online.Figure 3Enforced Expression and Knockdown of miR-126 Alters the Proliferation and Differentiation Status of Primitive 8227 AML Cells (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 4Enforced Expression of miR-126 Expands Primary AML LSC (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 4Enforced Expression of miR-126 Expands Primary AML LSC (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem CellsLechman et al.Cancer CellJanuary 28, 2016In BriefLechman et al. show that miR-126 targets the PI3K/AKT/MTOR signaling pathway to preserve quiescence, increase self-renewal, and promote chemotherapy resistance of acute myeloid leukemia stem cells (LSC). Reducing the miR-126 level impairs LSC maintenance in contrast to expanding normal hematopoietic stem cells. Full-Text PDF Open Access
New xenografts of human megakaryoblastic cell line (MEG-01) for evaluating anti-tumor agents. (1993)

A human megakaryoblastic cell line (MEG-01) was successfully transplanted into athymic nude mice. MEG-01 cells (5 x 10(7)) were inoculated subcutaneously in KSN-nu/nu mice, none of which were pretreated with irradiation or chemotherapeutic agents. All mice developed solid tumors at the site of injection after incubation for 10-14 days reaching a size of 200-400 mm2 (product of cross-sectional diameters) after 30 days. These tumors, designated as MEG-01/nu, were transplanted into other nude mice. The transplanted tumors infiltrated the liver and spleen, and leukemic megakaryoblastic cells appeared in the blood of some transplanted mice. Cells resuspended from MEG-01/nu tumors exhibited almost the same megakaryocytic characteristics as the original MEG-01 cells, and underwent in vitro differentiation to a mature form of megakaryocyte upon addition of phorbol diesters. MEG-01/nu was evaluated for sensitivity to cytosine arabinoside, vincristine, and daunorubicin in vitro and in vivo. Daunorubicin exhibited significant anti-tumor activity against MEG-01/nu in vivo, while cytosine arabinoside did so in vitro. Vincristine showed no activity against these cells. This cell line may provide a useful model for testing the in vivo efficacy of anti-tumor agents and immunotoxins, and for studying the pathophysiological mechanisms of human megakaryoblastic leukemia.
Alzheimer's disease in Down syndrome: Neurobiology and risk (2007)

Down syndrome (DS) is characterized by increased mortality rates, both during early and later stages of life, and age-specific mortality risk remains higher in adults with DS compared with the overall population of people with mental retardation and with typically developing populations. Causes of increased mortality rates early in life are primarily due to the increased incidence of congenital heart disease and leukemia, while causes of higher mortality rates later in life may be due to a number of factors, two of which are an increased risk for Alzheimer's disease (AD) and an apparent tendency toward premature aging. In this article, we describe the increase in lifespan for people with DS that has occurred over the past 100 years, as well as advances in the understanding of the occurrence of AD in adults with DS. Aspects of the neurobiology of AD, including the role of amyloid, oxidative stress, Cu/ZN dismutase (SOD-1), as well as advances in neuroimaging are presented. The function of risk factors in the observed heterogeneity in the expression of AD dementia in adults with DS, as well as the need for sensitive and specific biomarkers of the clinical and pathological progressing of AD in adults with DS is considered.
The research on Internet of things application architecture based on web (2014)

With the deepening of the research and development of embedded devices and the Internet of things technology widespread application, intelligent objects and types, increasing the number of the Internet of things devices constantly gained popularity in the People's Daily life. The development of digital and network technology makes the controller node, sensor node, radio frequency identification, and home appliances such as TV, air conditioning equipment can make use of the Internet protocol, wireless communication protocol to achieve information transmission and exchange. The Internet of things technology triggered a new wave of information industry, and with infinite commercial value. Internet of things based on Web application architecture and key technology research is of great practical significance.
Elevated amniotic fluid ferritin levels are associated with inflammation-related pregnancy loss following mid-trimester amniocentesis (2002)

The strong correlation of AF ferritin with IL-6 levels, along with the high ferritin values in cases with high AF IL-6, indicates that ferritin is a marker of inflammation in asymptomatic women destined to have an early pregnancy loss.
Androgen receptor expression in androgen‐independent prostate cancer cell lines (2001)

BACKGROUND Almost all attempts at establishing prostate carcinoma cell lines have resulted in generation of cells that are androgen-independent, including commonly used LNCaP which expresses androgen receptor (AR) and AR-negative Du145 and PC-3. We attempted to clarify the mechanism(s) responsible for the failure to respond to androgen. METHODS Cell lines LNCaP, CWR22R, PC-3, Du145, and CA7T2CL were used to examine the AR promoter function with a reporter gene assay and its methylation status by Southern blot, PCR of bisulfite-converted DNA, and 5-aza-2′-deoxycytidine treatment. Structural abnormalities of the AR were identified by sequencing of reverse-transcribed mRNA. RESULTS All tested AR-positive prostate carcinoma cells were capable of AR transcription at a significantly higher level than PC-3 and Du145, thus suggesting relative deficiency of the transcription factors in the AR-negative cells, further associated with methylation. Examination of CWR22R cells, which express the AR but are androgen-independent, identified an in-frame duplication of exon 3, which resulted in insertion of 39 amino acids in the DNA-binding domain. CONCLUSIONS Relative deficiency of transcription factors associated with methylation is responsible for the lack of AR promoter function in most of AR-negative cell lines. Mutations in the AR gene are present in the cells that express the AR but are androgen-independent. Prostate 47:66–75, 2001. © 2001 Wiley-Liss, Inc.
Heat‐solubilized curry spice curcumin inhibits antibody–antigen interaction in <i>in vitro</i> studies: A possible therapy to alleviate autoimmune disorders (2010)

Chronic and complex autoimmune diseases, currently treated palliatively with immunosuppressives, require multi-targeted therapy for greater effectiveness. The naturally occurring polyphenol curcumin has emerged as a powerful "nutraceutical" that interacts with multiple targets to regress diseases safely and inexpensively. Up to 8 g/day of curcumin for 18 months was non-toxic to humans. However, curcumin's utility is limited by its aqueous insolubility. We have demonstrated a heat-mediated 12-fold increase in curcumin's aqueous solubility. Here, we show by SDS-PAGE and surface plasmon resonance that heat-solubilized curcumin binds to proteins. Based on this binding we hypothesized that heat-solubilized curcumin or turmeric would prevent autoantibody targeting of cognate autoantigens. Heat-solubilized curcumin/turmeric significantly decreased binding of autoantibodies from Sjögren's syndrome (up to 43/70%, respectively) and systemic lupus erythematosus (up to 52/70%, respectively) patients as well as an animal model of Sjögren's syndrome (up to 50/60%, respectively) to their cognate antigens. However, inhibition was not specific to autoimmunity. Heat-solubilized curcumin/turmeric also inhibited binding of commercial polyclonal anti-spectrin to spectrin (50/56%, respectively). Thus, we suggest that the multifaceted heat-solubilized curcumin can ameliorate autoimmune disorders. In addition, the non-toxic curcumin could serve as a new protein stain in SDS-PAGE even though it is less sensitive than the Coomassie system which involves toxic chemicals.
Carnitine in Valproate-Induced Hyperammonemia (1996)

The effect of carnitine supplementation in valproic acid (VPA) treated patients presenting with hyperammonemia was investigated in 69 children and young adults seen at the Zentrum der Kinderheilkunde, Goethe-Universitat Frankfurt, and Universitat Erlanger, FRG.
Capacity of BICM Using (Bi-)Orthogonal Signal Constellations in Impulse-Radio Ultra-Wideband Systems (2011)

Bit-interleaved coded modulation (BICM) using (bi-)orthogonal signals is especially well suited for the application in impulse-radio ultra-wideband transmission systems, which typically operate in the power-limited regime and require a very low-complexity transmitter and receiver design. In this paper we analyze the capacity of BICM using (bi-)orthogonal signals with coherent and noncoherent detection and put particular focus on the power-limited or wideband regime. We give analytical expressions for the ratio energy per bit vs. noise power spectral density in the limit of infinite bandwidth and the respective wideband slope, and thus, are able to quantify the loss incurred by the restriction to BICM in contrast to coded modulation. The gained theoretical insights allow to derive design rules for impulse-radio ultra-wideband transmission systems.
Tiger Nation: Empowering citizen scientists (2012)

The ever-increasing availability of online data and the advances of today's Web have enabled large-scale experimentation on data crowdsourcing and the effect of the individual on information extraction and knowledge generation. Tiger Nation, a project to promote preservation of the last remaining wild tigers in the world, utilises advanced technologies to unobtrusively track tigers and raise awareness as a participatory sensing exemplar. Through a tiger stripe recognition algorithm and gamification elements that complement the identification process, we have achieved higher levels of accuracy compared to the conventional means, as well as high levels of engagement from the community of users.
REVIEWS (1985)

REVIEWS WESTERN SYSTEMS OF JUVENILE JUSTICE. Edited by M. KLEIN. [Beverly Hills: Sage Publications. 1984. 240 pp. $22·00.] JUVENILE JUSTICE POLICY. Edited by S. DECKER. [Beverly Hills: Sage Publications. 1984. 168 pp. $17·95 (hardback) and $7·95 (softback).] Allison Morris Allison Morris Search for other works by this author on: Oxford Academic Google Scholar The British Journal of Criminology, Volume 25, Issue 3, July 1985, Pages 305–307, https://doi.org/10.1093/oxfordjournals.bjc.a047544 Published: 01 July 1985