gebhart/patrepeval huggingface dataset:
Uplink Interference Management for HSPA+ and 1xEVDO Femtocells (2009)

Femtocells are low power cellular base stations typically deployed indoors in residential and enterprise environments as well as hotspots in order to improve voice and high rate data coverage and provide excellent user experience. The cellular operator benefits from reduced infrastructure deployment costs for capacity upgrades and coverage improvements. While improving performance, femtocells may cause some interference to other users in the network. However, with the use of proper interference management techniques, this interference may be well controlled. This paper focuses on uplink (UL) interference management techniques for 3G femtocell deployments. On the UL, the challenge is the presence of large uncontrolled interference from nearby users not associated by the femtocell that result in high noise rise (rise-over-thermal, RoT), that may lead to poor femto user experience. Femtocell users that can not be power controlled due to their very close proximity to femtocells may also cause high noise rise levels. An algorithm is proposed for both HSPA+ and 1xEVDO femtocells to desensitize the receiver when uncontrolled interference is detected, ensuring robust UL performance with minimal impact on the macro network. It is demonstrated through system level simulations that in addition to superior performance experienced by femtocell users, the macro users also benefit significantly from offloading traffic load to the femto network.
Memristors as radiofrequency switches (2016)

In this paper, we introduce a novel application of memristor as a radiofrequency (RF) switch. We design and build a nanoscale memristor by placing gold and silver electrodes on silicon oxide with a 35 nm airgap in between. We program the device with a voltage as low as -0.4 V and achieve an ON/OFF conductance ratio of 1012. We test the RF performance of the device up to 110 GHz and report 0.3 dB insertion loss, 30 dB isolation (both at 40 GHz) and an average 35 THz cutoff frequency.
Computational study of clot formation in aneurysms treated with shape memory polymer foam (2019)

To prevent aneurysmal rupture, intracranial aneurysms are often treated with endovascular metal coils that fill the aneurysm sac and stimulate thrombus formation, thereby isolating the aneurysm from the arterial flow. Despite its widespread use, this method can result in suboptimal outcomes leading to aneurysm recurrence. Recently, shape memory polymer foam has been proposed as an alternative aneurysm filler. In this work, a computational thrombus model is used to predict the clotting response within idealized 2D aneurysms virtually treated with foam. The results are compared to previously reported clot formation predictions in identical 2D aneurysm geometries filled with simplified endovascular metal coil shapes. Each of the foam-filled aneurysms reached at least 94% thrombus occlusion regardless of foam pore size or orientation, whereas the final thrombus occlusion within the coil-filled aneurysms varied from 80.8 to 92.2% with many of the cases leaving large areas in the aneurysm neck unfilled. Based on the simulations presented here, shape memory polymer foams may be able to produce more predictable, uniform, and complete clotting results than bare metal coils, independent of foam geometry or orientation.
Yarn-Level Cloth Simulation with Sliding Persistent Contacts (2016)

Cloth is made of yarns that are stitched together forming semi-regular patterns. Due to the complexity of stitches and patterns, the macroscopic behavior of cloth is dictated by the contact interactions between yarns, not by the mechanical properties of yarns alone. The computation of cloth mechanics at the yarn level appears as a computationally complex and costly process at first sight, due to the need to resolve many fine-scale contact interactions. We propose instead an efficient representation of cloth at the yarn level that treats yarn-yarn contacts as persistent, but with the possibility to slide, thereby avoiding expensive contact handling altogether. We introduce a compact representation of yarn geometry and kinematics, capturing the essential deformation modes of yarn crossings, loops, stitches, and stacks, with a minimum cost. Based on this representation, we design force models that reproduce the characteristic macroscopic behavior of yarn-based fabrics. Our approach is suited for both woven and knitted fabrics. We demonstrate the efficiency of our method on simulations with millions of degrees of freedom (hundreds of thousands of yarn loops), almost one order of magnitude faster than previous techniques. We also compare the different macroscopic behavior under woven and knitted patterns with the same yarn density.
Small long-range alpha detector (LRAD) with computer readout (1991)

The small long-range alpha detector developed by N-2 was described in detail in the Los Alamos publication LA-12073-MS, Long-Range Alpha Detector,'' published in 1991. Since publication of that report, a computerized data acquisition system has been added to the LRAD detector. In addition to detailing the new data acquisition system, we discuss new data generated with the enhanced system, including measurements of (1) ultimate sensitivity; (2) detector linearity; (3) ion lifetime; and (4) characteristics. Furthermore, we have expanded our understanding of ion recombination and statistical noise effects in the LRAD and have addressed them here as well as several proposed applications. 6 refs., 30 figs.
Topical Aminocaproic Acid Significantly Reduces the Incidence of Secondary Hemorrhage in Traumatic Hyphema in the Rabbit Model (1988)

• Systemically administered aminocaproic acid has been shown to reduce the incidence of secondary hemorrhage after traumatic hyphema. To date, no topical treatment has been shown to be effective in reducing the incidence of rebleeding in a double-masked study. Experimentally induced traumatic hyphemas in the rabbit model were treated with topical placebo gel (4% carboxypolymethylene gel only) or carboxypolymethylene gel with aminocaproic acid (treated group) in a double-masked fashion and were compared with untreated controls (control group). In both the control and placebo groups, there was a 33% rebleed rate. The treated eyes had a 10% rebleed rate that is statistically significant. The topically applied aminocaproic acid gel appears to be well tolerated locally without evidence of systemic toxicity. This study indicates that topical aminocaproic acid may be an effective alternative to systemic treatment to reduce the incidence of secondary hemorrhage in traumatic hyphema.
Early Clinical Assessment of the Antimicrobial Activity of Finafloxacin Compared to Ciprofloxacin in Subsets of Microbiologically Characterized Isolates (2018)

Two phase II studies were performed with patients with uncomplicated urinary tract infections (uUTIs) and complicated urinary tract infections (cUTIs) or acute pyelonephritis (PN) to compare finafloxacin (300 mg twice a day [b.i.d.] orally for uUTI and 800 mg once a day [q.d.] intravenously [i.v.] for cUTI/PN) and ciprofloxacin (250 mg b.i.d. orally for uUTI and 400 mg b.i.d. i.v. for cUTI/PN). The early response to the study medications was evaluated in the microbiological intent-to-treat population (mITT) at day 3. A total of 21% of the isolates were ciprofloxacin resistant, 13.7% were primed pathogens carrying a mutation(s) potentially fostering fluoroquinolone resistance development, and 7.1% produced extended-spectrum β-lactamases (ESBLs). Finafloxacin demonstrated very good early clinical activity, with microbiological eradication rates of 88.6% (<i>n</i> = 132), compared to 78.7% (<i>n</i> = 61) for ciprofloxacin, and 69.6% (<i>n</i> = 23), compared to 35.7% (<i>n</i> = 14) for ciprofloxacin, in patients with ciprofloxacin-resistant uropathogens; 94.1% (<i>n</i> = 17), compared to 80.0% (<i>n</i> = 10) for ciprofloxacin, in patients infected with uropathogens primed for fluoroquinolone resistance uropathogens; and 91.7% (<i>n</i> = 11), compared to 0% for ciprofloxacin, in patients infected with ESBL producers. Finafloxacin demonstrated early and rapid activity against uropathogens, including fluoroquinolone-resistant and/or multiresistant pathogens or ESBL producers, while ciprofloxacin was less active against this subset of resistant pathogens. Susceptibilities of pathogens were quantitated by broth microdilution. Isolates were subgrouped according to their susceptibility patterns, in particular first-step quinolone resistance, quinolone resistance, and ESBL production. Eradication was defined as the elimination or reduction of study entry pathogens to <10<sup>3</sup> CFU/ml in urine culture. (The studies described in this paper have been registered at ClinicalTrials.gov under identifiers NCT00722735 and NCT01928433.).
Design of a wide dynamic range rectifier array with an adaptive power distribution technique (2016)

This paper presents the design of a wide dynamic range rectifier array using a novel adaptive power distribution method. In such a rectifier array, the RF input power is distributed among multiple rectifier devices adaptively, according to their impedances as a function of input power level. Such a rectifier array can achieve high rectification efficiency and low reflection coefficient over a wide range of power levels. The method is experimentally verified with a 900 MHz two-device rectifier array, and demonstrated an efficiency higher than 50% over 17 dB dynamic range (10 dB wider than a conventional rectifier design using the same devices) with a peak efficiency of 66%.
Improved predictions of alarm and safety system performance through process and operator response‐time modeling (2016)

Dynamic risk analysis (DRA) has been used widely to analyze the performance of alarm and safety interlock systems of manufacturing processes. Because the most critical alarm and safety interlock systems are rarely activated, little or no data from these systems are often available to apply purely‐statistical DRA methods. Moskowitz et al. (2015) 1 introduced a repeated‐simulation, process‐model‐based technique for constructing informed prior distributions, generating low‐variance posterior distributions for Bayesian analysis, 1 and making alarm‐performance predictions. This article presents a method of quantifying process model quality, which impacts prior and posterior distributions used in Bayesian Analysis. The method uses higher‐frequency alarm and process data to select the most relevant constitutive equations and assumptions. New data‐based probabilistic models that describe important special‐cause event occurrences and operators’ response‐times are proposed and validated with industrial plant data. These models can be used to improve estimates of failure probabilities for alarm and safety interlock systems. © 2016 American Institute of Chemical Engineers AIChE J , 62: 3461–3472, 2016
Automated Ticketing of Email for ISP Customer Care (2001)

Email is emerging as an important channel for ISP customer care, and manual processing is labor intensive. A new system for automating the processing of large volumes of email received by an ISP customer care center is described. The system automatically determines the embedded email structure, extracts key email fields needed for aggregation and ticketing, performs keyword analysis, and invokes system utilities as needed. The production system processes up to 30,000 email requests per month, and has processed over 300,000 complaints to date.
Low-Power TCAMs for Very Large Forwarding Tables (2009)

Ternary content-addressable memories (TCAMs) may be used to obtain a simple and very fast implementation of a router's forwarding engine. The applicability of TCAMs is, however, limited by their size and high power requirement. Zane et al. proposed a method and associated algorithms to reduce the power needed to search a forwarding table using a TCAM. We improve on both the algorithms proposed by them. Additionally, we show how to couple TCAMs and high-bandwidth SRAMs so as to overcome both the power and size limitations of a pure TCAM forwarding engine. By using one of our novel TCAM-SRAM coupling schemes (M-12 Wb), we are able to reduce TCAM memory by a factor of about 5 on IPv4 data sets and by a factor of about 2.5 on IPv6 data sets; TCAM power requirement is reduced by a factor of about 10 on IPv4 data sets and by a factor of about 6 on IPv6 data sets. These comparisons are with respect to the improved TCAM algorithms we have developed for the strategies of Zane et al. The stated improvements come at the cost of increasing SRAM requirement by a factor 2.5 for IPv4 data and a factor of 5 for IPv6 data. This cost is unimportant given that SRAMs are relatively quite cheap and have much less power requirement. For another of our novel TCAM-SRAM coupling schemes (1-12Wc), the TCAM memory and power reduced by factors of about 4 and 12 for IPv4 data sets, respectively, and by factors of about 2 and 10 for IPv6 data sets. The SRAM required, however, increased by factors of 3 and 7, respectively. These improvements come with no loss in the time (as measured by the number of TCAM searches and SRAM accesses) to do a lookup.
An Infant Formula with Large, Milk Phospholipid-Coated Lipid Droplets Supports Adequate Growth and Is Well-Tolerated in Healthy, Term Asian Infants: A Randomized, Controlled Double-Blind Clinical Trial (2022)

Lipids are essential for healthy infant growth and development. The structural complexity of lipids in human milk is not present in infant milk formula (IF). A concept IF was developed mimicking more closely the structure and composition of human milk fat globules. The current study evaluates whether a concept IF with large, milk phospholipid-coated lipid droplets (mode diameter 3 to 5 μm) is equivalent to standard IF with regard to growth adequacy and safety in healthy, term Asian infants. In this randomized, double-blind, controlled trial, infants were randomized after parents decided to introduce formula. Infants received a standard IF with (Control) or without the specific prebiotic mixture scGOS/lcFOS (9:1 ratio; Control w/o prebiotics), or a Concept IF with large, milk phospholipid-coated lipid droplets and the prebiotic mixture. A group of 67 breastfed infants served as a reference. As a priori defined, only those infants who were fully intervention formula-fed ≤28 days of age were included in the equivalence analysis (Control n = 29; Control w/o prebiotics n = 28; Concept n = 35, per-protocol population). Primary outcome was daily weight gain during the first four months of life, with the difference between the Concept and Control as the key comparison of interest. Additionally, adverse events, growth and tolerance parameters were evaluated. Equivalence of daily weight gain was demonstrated between the Concept and Control group after additional correction for ethnicity and birthweight (difference in estimated means of 0.1 g/d, 90%CI [-2.30, 2.47]; equivalence margin +/- 3 g/d). No clinically relevant group differences were observed in secondary growth outcomes, tolerance outcomes or number, severity or relatedness of adverse events. This study corroborates that an infant formula with large, milk phospholipid-coated lipid droplets supports adequate growth and is well tolerated and safe for use in healthy infants.
Simulation Study of Reduced Self-Heating in Novel Thin-SOI Vertical Bipolar Transistors (2005)

Simulations have been performed to study the self-heating in thin-SOI, vertical bipolar transistors for the first time. Two new device structures are proposed and the simulations show that they can improve the heat dissipation significantly. By adding a heat sink connecting the collector and the substrate and/or having a thin localized BOX underneath the SOI collector, self-heating can be reduced substantially without increasing device area or degrading device performance.
Purification of Mutacin III from Group III <i>Streptococcus mutans</i> UA787 and Genetic Analyses of Mutacin III Biosynthesis Genes (1999)

Previously, members of our group reported the isolation and characterization of mutacin II from Streptococcus mutans T8 and the genetic analyses of the mutacin II biosynthesis genes (J. Novak, P. W. Caufield, and E. J. Miller, J. Bacteriol. 176:4316-4320, 1994; F. Qi, P. Chen, and P. W. Caufield, Appl. Environ. Microbiol. 65:652-658, 1999; P. Chen, F. Qi, J. Novak, and P. W. Caufield, Appl. Environ. Microbiol. 65:1356-1360, 1999). In this study, we cloned and sequenced the mutacin III biosynthesis gene locus from a group III strain of S. mutans, UA787. DNA sequence analysis revealed eight open reading frames, which we designated mutR, -A, -A', -B, -C, -D, -P, and -T. MutR bears strong homology with MutR of mutacin II, while MutA, -B, -C, -D, -P, and -T are counterparts of proteins in the lantibiotic epidermin group. MutA' has 60% amino acid identity with MutA and therefore appears to be a duplicate of MutA. Insertional inactivation demonstrated that mutA is an essential gene for mutacin III production, while mutA' is not required. Mutacin III was purified to homogeneity by using reverse-phase high-pressure liquid chromatography. N-terminal peptide sequencing of the purified mutacin III determined mutA to be the structural gene for prepromutacin III. The molecular mass of the purified peptide was measured by laser disorption mass spectrophotometry and found to be 2,266.43 Da, consistent with our supposition that mutacin III has posttranslational modifications similar to those of the lantibiotic epidermin.
Antigen-Specific Blockade of T Cells In Vivo Using Dimeric MHC Peptide (2001)

Ag-specific immune tolerance in clinical organ transplantation is currently an unrealized but critical goal of transplant biology. The specificity and avidity of multimerized MHC-peptide complexes suggests their potential ability to modulate T cell sensitization and effector functions. In this study, we examined the ability of MHC-peptide dimers to modulate T cell function both in vitro and in vivo. Soluble MHC dimers induced modulation of surface TCR expression and inhibited T cell cytolytic activity at nanomolar concentrations in vitro. Furthermore, engagement of TCR by soluble dimers resulted in phosphorylation of the TCR zeta-chain and recruitment and phosphorylation of zeta-associated protein-70 to the signaling complex, the latter of which increased upon dimer cross-linking. Significantly, Ag-specific inhibition of an alloreactive TCR-transgenic T cell population in vivo resulted in consequent outgrowth of an allogeneic tumor. The prolonged Ag-specific suppression of expansion and/or effector function of cognate T cells in vivo suggests that soluble MHC dimers may be a means of inducing sustained Ag-specific T cell unresponsiveness in vivo.
New trends in combined use of gonadotropin-releasing hormone antagonists with gonadotropins or pulsatile gonadotropin-releasing hormone in ovulation induction and assisted reproductive technologies (1992)

The use of gonadotropin-releasing hormone agonists as adjunctive therapy with gonadotropins for ovulation induction in in vitro fertilization and other assisted reproductive technologies has become common clinical practice. With the recent advent of potent gonadotropin-releasing hormone antagonists free from the marked histamine-release effects that stymied earlier compounds, an attractive alternative method may be available. We have established the feasibility of combining gonadotropin-releasing hormone antagonist-induced inhibition of endogenous gonadotropins with exogenous gonadotropin therapy for ovulation induction in a nonhuman primate model. Here, the principal benefits to be gained from using the gonadotropin-releasing hormone antagonist rather than the gonadotropin-releasing hormone agonist are the immediate inhibition of pituitary gonadotropin secretion without the "flare effect," which brings greater safety and convenience for patients and the medical team and saves time and money. We have also recently demonstrated the feasibility of combining gonadotropin-releasing hormone antagonist with pulsatile gonadotropin-releasing hormone therapy for the controlled restoration of gonadotropin secretion and gonadal steroidogenesis culminating in apparently normal (singleton) ovulatory cycles. This is feasible only with gonadotropin-releasing hormone antagonists because, unlike gonadotropin-releasing hormone agonists, they achieve control of the pituitary-ovarian axis without down regulation of the gonadotropin-releasing hormone receptor system. This capacity to override gonadotropin-releasing hormone antagonist-induced suppression of pituitary-ovarian function may allow new treatment modalities to be employed for women who suffer from chronic hyperandrogenemia with polycystic ovarian disease.
Biometric-rich gestures (2012)

In this paper, we present a novel multi-touch gesture-based authentication technique. We take advantage of the multi-touch surface to combine biometric techniques with gestural input. We defined a comprehensive set of five-finger touch gestures, based upon classifying movement characteristics of the center of the palm and fingertips, and tested them in a user study combining biometric data collection with usability questions. Using pattern recognition techniques, we built a classifier to recognize unique biometric gesture characteristics of an individual. We achieved a 90% accuracy rate with single gestures, and saw significant improvement when multiple gestures were performed in sequence. We found user ratings of a gestures desirable characteristics (ease, pleasure, excitement) correlated with a gestures actual biometric recognition rate - that is to say, user ratings aligned well with gestural security, in contrast to typical text-based passwords. Based on these results, we conclude that multi-touch gestures show great promise as an authentication mechanism.
Explicit construction of optimal exact regenerating codes for distributed storage (2009)

Erasure coding techniques are used to increase the reliability of distributed storage systems while minimizing storage overhead. Also of interest is minimization of the bandwidth required to repair the system following a node failure. In a recent paper, Wu et al. characterize the tradeoff between the repair bandwidth and the amount of data stored per node. They also prove the existence of regenerating codes that achieve this tradeoff. In this paper, we introduce Exact Regenerating Codes, which are regenerating codes possessing the additional property of being able to duplicate the data stored at a failed node. Such codes require low processing and communication overheads, making the system practical and easy to maintain. Explicit construction of exact regenerating codes is provided for the minimum bandwidth point on the storage-repair bandwidth tradeoff, relevant to distributed-mail-server applications. A subspace based approach is provided and shown to yield necessary and sufficient conditions on a linear code to possess the exact regeneration property as well as prove the uniqueness of our construction. Also included in the paper, is an explicit construction of regenerating codes for the minimum storage point for parameters relevant to storage in peer-to-peer systems. This construction supports a variable number of nodes and can handle multiple, simultaneous node failures. All constructions given in the paper are of low complexity, requiring low field size in particular.