gebhart/patrepeval huggingface dataset:
Shake'n'sense (2012)

We present a novel yet simple technique that mitigates the interference caused when multiple structured light depth cameras point at the same part of a scene. The technique is particularly useful for Kinect, where the structured light source is not modulated. Our technique requires only mechanical augmentation of the Kinect, without any need to modify the internal electronics, firmware or associated host software. It is therefore simple to replicate. We show qualitative and quantitative results highlighting the improvements made to interfering Kinect depth signals. The camera frame rate is not compromised, which is a problem in approaches that modulate the structured light source. Our technique is non-destructive and does not impact depth values or geometry. We discuss uses for our technique, in particular within instrumented rooms that require simultaneous use of multiple overlapping fixed Kinect cameras to support whole room interactions.
Permanent magnet properties of rapidly quenched rare earth-iron alloys (1982)

Recent studies have demonstrated the potential of producing rare earth-iron permanent magnets by rapid quench processing. High coercivity, unachievable by traditional powder-metallurgy methods, has been obtained either by crystallization of an amorphous or rapidly quenched precursor or by direct-quenching. Results obtained by both techniques on a variety of rare earth-iron alloys are discussed. In particular, melt-spun Nd-Fe and Pr-Fe alloys develop an appreciable maximum (7-9 kOe) in room temperature coercivity (H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ci</inf> ) as a function of quench rate, which is controlled by varying the surface velocity of the melt-spinner substrate. Even higher H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ci</inf> (>20 kOe) has been observed in Sm-Fe. Magnetic and crystallization properties suggest that the coercive force of these materials is related to the formation of one or more metastable rare earth-iron phases.
Effects of dietary potassium citrate supplementation on urine pH and urinary relative supersaturation of calcium oxalate and struvite in healthy dogs (2000)

Dietary potassium citrate supplementation has limited effects on urinary variables in most healthy dogs, although supplementation results in maintenance of a higher urine pH later in the day. Consequently, if supplementation is introduced, dogs should be fed twice daily and potassium citrate should be given with both meals or with the evening meal only.
Self-Aligning, Spline-Locking Fastener (1992)

Self-aligning, spline-locking fastener is two-part mechanism operated by robot, using one tool and simple movements. Spline nut on springloaded screw passes through mating spline fitting. Operator turns screw until vertical driving surfaces on spline nut rest against corresponding surfaces of spline fitting. Nut rides upward, drawing pieces together. Used to join two parts of structure, to couple vehicles, or to mount payload in vehicle.
Thiophene systems. 5. Thieno[3,4-b][1,5]benzoxazepines, thieno[3,4-b][1,5]benzothiazepines, and thieno[3,4-b][1,4]benzodiazepines as potential central nervous system agents (1981)

10-(Alkylamino)thieno[3,4-b][1,5]benzoxazepines (3) and 10-(alkylamino)thieno[3,4-b][1,5]benzothiazepines (4) were prepared by derivatization of the respective lactams (7 and 8) via phosphorus pentachloride and subsequent condensation with the appropriate alkylamines. 9-(Alkylamino)-4H-thieno[3,4-b][1,4]benzodiazepines (5) were prepared by titanium tetrachloride catalyzed condensation of the lactam 11 with alkylamines. 9-(Alkylamino)-4-methylthieno[3,4-b][1,4]benzodiazepines (6) were prepared by reductive alkylation of 5. The compounds were tested for potential neuroleptic activity by means of the blockade of d-amphetamine lethality in aggregated mice and/or effects on locomotor activity in rats. Antidepressant activity was examined using inhibition of tetrabenazine-induced depression in mice. Most of the title compounds 3-6 were found to have neuroleptic activity. In addition, introduction of a 3-chloro substituent in the oxygen and sulfur systems (3p and 4c), as well as introduction of an N-alkyl in the dinitrogen system (6), was found to produce antidepressant effects. Structure-activity relationships are discussed.
Abstract 683: Evaluating the therapeutic potential of a peptide derivative of cancer-associated PCNA in DNA repair deficient breast cancers (2010)

Abstract Our laboratory was the first to isolate and purify an intact mammalian cell multiprotein DNA replication complex, termed the synthesome, from a variety of human cell types that was both stable and fully functional. Subsequent work revealed that the synthesome of malignant breast epithelial cells exhibits a more error-prone synthesis process than that of nonmalignant breast epithelial cells. We recently correlated the low replication fidelity of malignant cells was due at least in part to a post-translational modification of a specific protein component of the synthesome: proliferating cell nuclear antigen, or PCNA. Our laboratory developed an antibody (cancer-associated or caPCNAab) specific to the cancer-associated PCNA isoform (cancer-associated or caPCNA), providing hope of an effective diagnostic marker of malignancy. Additionally, peptides were derived from the caPCNA sequence (caPeptides) and these peptides were shown to augment the action of doxorubicin (DOX) in leukemia cells while leaving nonmalignant cells intact. caPeptides may possess anti-cancer therapeutic potential through blocking the association of caPCNA with its binding partners involved in DNA replication and repair. The objective of this study was to determine the mechanism by which caPeptides directed against caPCNA induced cancer cell cytotoxicity. Breast cancer cells from a patient harboring a hereditary mutation in BRCA1, a major component of DNA double strand break repair (HCC1937 cells), were used in this study. As a genetically matched control, the wild-type breast cancer 1 early onset gene (BRCA1) was transduced into HCC1937 cells (referred to as HCC1937 + wild-type BRCA1). MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays were conducted with caPeptides at a variety of timepoints both alone and in combination with DNA damaging agent cisplatin in HCC1937 and HCC1937 + wild-type BRCA1 cells. The data suggests cells lacking wild-type BRCA1 show increased sensitivity to caPeptides in comparison to isogenic controls transduced with wild-type BRCA1. We show that caPeptides augment the action of DNA damaging agent cisplatin. Furthermore, caPeptides containing amino acid substitutions in specific sites within the peptide show enhanced cytotoxicity over wild-type caPeptides. This work may provide information useful in a clinical setting as caPeptides could benefit a particular subset of breast cancer patients. Additionally, caPeptide studies may shed light on the deregulated replication and repair processes common in cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 683.
Peptide-Mediated Targeting to Tumor Blood Vessels of Lung Cancer for Drug Delivery (2007)

Antiangiogenesis therapies for the treatment of cancers hold the promise of high efficacy and low toxicity. In vivo phage display was used to identify peptides specifically targeting tumor blood vessels. The peptide SP5-52 recognized tumor neovasculature but not normal blood vessels in severe combined immunodeficiency mice bearing human tumors. Synthetic peptide was shown to inhibit the binding of PC5-52 phage particles to the tumor mass in the competitive inhibition assay. Several selected phage clones displayed the consensus motif, proline-serine-proline, and this motif was crucial for peptide binding to the tumor neovasculature. SP5-52 peptides also bound vascular endothelial growth factor-stimulated human umbilical vein endothelial cells and blood vessels of human lung cancer surgical specimens. Furthermore, this targeting phage was shown to home to tumor tissues from eight different types of human tumor xenografts following in vivo phage display experiments. An SP5-52 peptide-linked liposome carrying doxorubicin enhanced the therapeutic efficacy of the drug, markedly decreased tumor blood vessels, and resulted in higher survival rates of human lung and oral cancer-bearing xenograft mice. The current study indicates that ligand-targeted therapy offers improved therapeutic effects over conventional anticancer drug therapy, and that the peptide SP5-52 specifically targets tumor neovasculature and is a good candidate for targeted drug delivery to solid tumors.
Characterization of liquid absorption and emission spectra using linear variable filters integrated with a CMOS camera (2016)

A compact analysis platform for detecting liquid absorption and emission spectra using a set of linear variable filters atop a CMOS image sensor is presented to cover wide spectral ranges and provide low detection limits.
The Rutgers Master II-new design force-feedback glove (2002)

The Rutgers Master II-ND glove is a haptic interface designed for dextrous interactions with virtual environments. The glove provides force feedback up to 16 N each to the thumb, index, middle, and ring fingertips. It uses custom pneumatic actuators arranged in a direct-drive configuration in the palm. Unlike commercial haptic gloves, the direct-drive actuators make unnecessary cables and pulleys, resulting in a more compact and lighter structure. The force-feedback structure also serves as position measuring exoskeleton, by integrating noncontact Hall-effect and infrared sensors. The glove is connected to a haptic-control interface that reads its sensors and servos its actuators. The interface has pneumatic servovalves, signal conditioning electronics, A/D/A boards, power supply and an imbedded Pentium PC. This distributed computing assures much faster control bandwidth than would otherwise be possible. Communication with the host PC is done over an RS232 line. Comparative data with the CyberGrasp commercial haptic glove is presented.
Enhanced ship detection from overhead imagery (2008)

In the authors' previous work, a sequence of image-processing algorithms was developed that was suitable for detecting and classifying ships from panchromatic Quickbird electro-optical satellite imagery. Presented in this paper are several new algorithms, which improve the performance and enhance the capabilities of the ship detection software, as well as an overview on how land masking is performed. Specifically, this paper describes the new algorithms for enhanced detection including for the reduction of false detects such as glint and clouds. Improved cloud detection and filtering algorithms are described as well as several texture classification algorithms are used to characterize the background statistics of the ocean texture. These detection algorithms employ both cloud and glint removal techniques, which we describe. Results comparing ship detection with and without these false detect reduction algorithms are provided. These are components of a larger effort to develop a low-cost solution for detecting the presence of ships from readily-available overhead commercial imagery and comparing this information against various open-source ship-registry databases to categorize contacts for follow-on analysis.
A study of mobile proxy for privacy enhancement (2010)

Radio frequency identification (RFID) is a promising technology for identifying physical objects in an automated manner, but raises privacy infringement problems significantly in the real world. The low-cost RFID tags are much more vulnerable, meaning traceable, than active tags due to their restricted (poor) capabilities. In this paper, we present a practical method for enhancing the privacy of consumers, who may hold low-cost tags in everyday life, through a mobile phone. We set the mobile phone as a mobile proxy, which registers and renames RFID tags, monitors radio communications, and simulates the low-cost tags for privacy enhancement, along with providing a user setting mechanism for privacy levels.
Assessment of Preterm Birth Risk by Collagen Scoring with Polarized Light in Mice Model of Pregnancy (2022)

Polarimetric images of thin histological sections of uterine cervices from non-pregnant and pregnant mice were recorded with Mueller matrix microscope. The results of two-Gaussian fit of the distributions of linear scalar retardance of cervical tissue demonstrated that imaging Mueller polarimetry may quantify the evolution of cervical collagen with pregnancy. It opens the avenue for a fast and non-contact polarimetric assessment of the preterm birth risk.
Clinical and genomic insights into circulating tumor DNA-based alterations across the spectrum of metastatic hormone-sensitive and castrate-resistant prostate cancer (2020)

Several funding sources have supported this study. A full list is provided in the Acknowledgments. No funding was received from Predicine, Inc. during the conduct of the study.
A better understanding and an improved solution to the problems of stereophonic acoustic echo cancellation (2002)

Teleconferencing systems employ acoustic echo cancelers (AECs) to reduce echos that result from coupling between the loudspeaker and microphone. To enhance the sound realism, two-channel audio is necessary. However, in this case (stereophonic sound) the acoustic echo cancellation problem is more difficult to solve because of the necessity to uniquely identify two acoustic paths. We explain these problems in detail and give an interesting solution which is much better than previously known solutions. The basic idea is to introduce a small nonlinearity into each channel that has the effect of reducing the interchannel coherence while not being noticeable for speech due to self masking.
A Randomized Trial of Inhaled Cyclosporine in Lung-Transplant Recipients (2006)

Inhaled cyclosporine did not improve the rate of acute rejection, but it did improve survival and extend periods of chronic rejection-free survival. (ClinicalTrials.gov number, NCT00268515.).
User-centered methods for rapid creation and validation of Bayesian belief networks (2007)

Bayesian networks (BN) are particularly well suited to capturing vague and uncertain knowledge. However, the capture of this knowledge and associated reasoning from human domain experts often requires specialized knowledge engineers and computational modelers responsible for creating BN-based models. Through our experiences in applying BN modeling techniques across application domains, we have analyzed how these models are constructed, refined, and validated with domain experts. From this analysis, we have identified potential simplifying assumptions and used these to guide the design of computational and user interface methods that support the rapid creation and validation of BN models.
Detection of Mycobacterium tuberculosis Peptides in the Exosomes of Patients with Active and Latent M. tuberculosis Infection Using MRM-MS (2014)

The identification of easily measured, accurate diagnostic biomarkers for active tuberculosis (TB) will have a significant impact on global TB control efforts. Because of the host and pathogen complexities involved in TB pathogenesis, identifying a single biomarker that is adequately sensitive and specific continues to be a major hurdle. Our previous studies in models of TB demonstrated that exosomes, such as those released from infected macrophages, contain mycobacterial products, including many Mtb proteins. In this report, we describe the development of targeted proteomics assays employing multiplexed multiple reaction monitoring mass spectrometry (MRM-MS) in order to allow us to follow those proteins previously identified by western blot or shotgun mass spectrometry, and enhance biomarker discovery to include detection of Mtb proteins in human serum exosomes. Targeted MRM-MS assays were applied to exosomes isolated from human serum samples obtained from culture-confirmed active TB patients to detect 76 peptides representing 33 unique Mtb proteins. Our studies revealed the first identification of bacteria-derived biomarker candidates of active TB in exosomes from human serum. Twenty of the 33 proteins targeted for detection were found in the exosomes of TB patients, and included multiple peptides from 8 proteins (Antigen 85B, Antigen 85C, Apa, BfrB, GlcB, HspX, KatG, and Mpt64). Interestingly, all of these proteins are known mycobacterial adhesins and/or proteins that contribute to the intracellular survival of Mtb. These proteins will be included as target analytes in future validation studies as they may serve as markers for persistent active and latent Mtb infection. In summary, this work is the first step in identifying a unique and specific panel of Mtb peptide biomarkers encapsulated in exosomes and reveals complex biomarker patterns across a spectrum of TB disease states.
View synthesis optimization based on texture smoothness for 3D-HEVC (2015)

This paper presents view synthesis optimization for 3D-HEVC based on a new texture smoothness process. In the original method, all pixels are exhaustively rendered to get distortions from synthesized views. Since not all pixels from the distorted depth map may cause distortions in the synthesized view, it brings unnecessary coding complexity. In this paper, lines of pixels are skipped based on the analysis of pixel regularity from smooth texture regions. It is due to the fact that the distorted disparity may not have much effect on the synthesized view in smooth texture regions. The proposed method can reduce the coding complexity of view synthesis optimization without significant performance loss.
Resistance gene <i>N</i> -mediated <i>de novo</i> synthesis and activation of a tobacco mitogen-activated protein kinase by tobacco mosaic virus infection (1998)

Salicylic acid-induced protein kinase (SIPK) and wounding-induced protein kinase (WIPK), two distinct members of the mitogen-activated protein (MAP) kinase family, are activated in tobacco resisting infection by tobacco mosaic virus (TMV). WIPK activation by TMV depends on the disease-resistance gene N because infection of susceptible tobacco not carrying the N gene failed to activate WIPK. Activation of WIPK required not only posttranslational phosphorylation but also a preceding rise in its mRNA and de novo synthesis of WIPK protein. The induction by TMV of WIPK mRNA and protein also occurred systemically. Its activation at the mRNA, protein, and enzyme levels was independent of salicylic acid. The regulation of WIPK at multiple levels by an N gene-mediated signal(s) suggests that this MAP kinase may be an important component upstream of salicylic acid in the signal-transduction pathway(s) leading to local and systemic resistance to TMV.
Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix) (2020)

Raman Chemometric Urinalysis (RametrixTM) was used to discern differences in Raman spectra from (i) 362 urine specimens from patients receiving peritoneal dialysis (PD) therapy for end-stage kidney disease (ESKD), (ii) 395 spent dialysate specimens from those PD therapies, and (iii) 235 urine specimens from healthy human volunteers. RametrixTM analysis includes spectral processing (e.g., truncation, baselining, and vector normalization); principal component analysis (PCA); statistical analyses (ANOVA and pairwise comparisons); discriminant analysis of principal components (DAPC); and testing DAPC models using a leave-one-out build/test validation procedure. Results showed distinct and statistically significant differences between the three types of specimens mentioned above. Further, when introducing "unknown" specimens, RametrixTM was able to identify the type of specimen (as PD patient urine or spent dialysate) with better than 98% accuracy, sensitivity, and specificity. RametrixTM was able to identify "unknown" urine specimens as from PD patients or healthy human volunteers with better than 96% accuracy (with better than 97% sensitivity and 94% specificity). This demonstrates that an entire Raman spectrum of a urine or spent dialysate specimen can be used to determine its identity or the presence of ESKD by the donor.
Identification and Characterization of a Well-Defined Series of Coronatine Biosynthetic Mutants of <i>Pseudomonas syringae</i> pv. <i>tomato</i> DC3000 (2004)

To identify Pseudomonas syringae pv. tomato genes involved in pathogenesis, we carried out a screen for Tn5 mutants of P. syringae pv. tomato DC3000 with reduced virulence on Arabidopsis thaliana. Several mutants defining both known and novel virulence loci were identified. Six mutants contained insertions in biosynthetic genes for the phytotoxin coronatine (COR). The P. syringae pv. tomato DC3000 COR genes are chromosomally encoded and are arranged in two separate clusters, which encode enzymes responsible for the synthesis of coronafacic acid (CFA) or coronamic acid (CMA), the two defined intermediates in COR biosynthesis. High-performance liquid chromatography fractionation and exogenous feeding studies confirmed that Tn5 insertions in the cfa and cma genes disrupt CFA and CMA biosynthesis, respectively. All six COR biosynthetic mutants were significantly impaired in their ability to multiply to high levels and to elicit disease symptoms on A. thaliana plants. To assess the relative contributions of CFA, CMA, and COR in virulence, we constructed and characterized cfa6 cmaA double mutant strains. These exhibited virulence phenotypes on A. thalliana identical to those observed for the cmaA or cfa6 single mutants, suggesting that reduced virulence of these mutants on A. thaliana is caused by the absence of the intact COR toxin. This is the first study to use biochemically and genetically defined COR mutants to address the role of COR in pathogenesis.
Superconducting Single-Photon Detectors for Integrated Nanophotonics Circuits (2017)

We present an overview of our recent achievements in integration of superconducting nanowire single-photon detectors SNSPD with dielectric optical waveguides. We are able to produce complex nanophotonics integrated circuits containing optical elements and photon detector on single chip thus producing a compact integrated platform for quantum optics applications.
Calibration of very fast TLP transients (2009)

A calibration methodology for transient analysis of voltage and current waveforms during VFTLP testing is presented. An OPEN, SHORT and LOAD calibration are required to de-embed the probe needles and system parasitics. This enables the use of non-RF probes for VFTLP measurements, resulting in a lower cost and higher measurement flexibility for VFTLP testing.
Chronic Manifestation of Postreperfusion Intramyocardial Hemorrhage as Regional Iron Deposition (2013)

Hemorrhagic myocardial infarction can lead to iron depositions within the infarct zones, which can be a source of prolonged inflammatory burden in the chronic phase of myocardial infarction.