gebhart/patrepeval huggingface dataset:
Identification and validation of expressed HLA-binding breast cancer neoepitopes for potential use in individualized cancer therapy (2021)

We demonstrate our neoepitope prediction program allows for the successful identification of neoepitopes targeted by TILs in patients with BC, providing a means to identify tumor-specific immunogenic targets for individualized treatment, including vaccines or adoptively transferred cellular therapies.
ChemInform Abstract: SYNTHESIS AND ANTITUMOR ACTIVITY OF NEW PLATINUM COMPLEXES (1983)

Abstract Aus verschiedenen Aminen, z.B. (I)‐(IV), werden mit dem Tetrachloroplatinat (V) Platinkomplexe hergestellt, die gute Wirkung gegen L1210‐Leukämie besitzen.
Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes (2011)

Adolescent idiopathic scoliosis (AIS) is an unexplained and common spinal deformity seen in otherwise healthy children. Its pathophysiology is poorly understood despite intensive investigation. Although genetic underpinnings are clear, replicated susceptibility loci that could provide insight into etiology have not been forthcoming. To address these issues, we performed genome-wide association studies (GWAS) of ∼327 000 single nucleotide polymorphisms (SNPs) in 419 AIS families. We found strongest evidence of association with chromosome 3p26.3 SNPs in the proximity of the CHL1 gene (P < 8 × 10(-8) for rs1400180). We genotyped additional chromosome 3p26.3 SNPs and tested replication in two follow-up case-control cohorts, obtaining strongest results when all three cohorts were combined (rs10510181 odds ratio = 1.49, 95% confidence interval = 1.29-1.73, P = 2.58 × 10(-8)), but these were not confirmed in a separate GWAS. CHL1 is of interest, as it encodes an axon guidance protein related to Robo3. Mutations in the Robo3 protein cause horizontal gaze palsy with progressive scoliosis (HGPPS), a rare disease marked by severe scoliosis. Other top associations in our GWAS were with SNPs in the DSCAM gene encoding an axon guidance protein in the same structural class with Chl1 and Robo3. We additionally found AIS associations with loci in CNTNAP2, supporting a previous study linking this gene with AIS. Cntnap2 is also of functional interest, as it interacts directly with L1 and Robo class proteins and participates in axon pathfinding. Our results suggest the relevance of axon guidance pathways in AIS susceptibility, although these findings require further study, particularly given the apparent genetic heterogeneity in this disease.
Handover for a portable communication device between local and wide area wireless networks (2010)

The present invention relates to a method, call handling server (18), local wireless network (10) and computer program product for performing vertical handover of a wireless voice connection, which ...
Fast Correction of Network Parameter Errors (2017)

In this letter, a fast network parameter error correction scheme is proposed based on recent findings on parameter error identification. Compared to the widely applied augmented state estimation approach, it is computationally very efficient and numerically stable, and requires very modest coding effort. Simulation results in the New England power system show that it produces reliable results in the presence of both strongly correlated errors and Gaussian measurement noise.
Rapid Uptake and Photodynamic Inactivation of Staphylococci by Ga(III)-Protoporphyrin IX (2018)

Antimicrobial photodynamic therapy (aPDT) is a promising method for the topical treatment of drug-resistant staphylococcal infections and can be further improved by identifying mechanisms that increase the specificity of photosensitizer uptake by bacteria. Here we show that Ga(III)-protoporphyrin IX chloride (Ga-PpIX), a fluorescent hemin analog with previously undisclosed photosensitizing properties, can be taken up within seconds by Staphylococcus aureus including multidrug-resistant strains such as MRSA. The uptake of Ga-PpIX by staphylococci is likely diffusion-limited and is attributed to the expression of high-affinity cell-surface hemin receptors (CSHRs), namely iron-regulated surface determinant (Isd) proteins. A structure-activity study reveals the ionic character of both the heme center and propionyl groups to be important for uptake specificity. Ga-PpIX was evaluated as a photosensitizer against S. aureus and several clinical isolates of MRSA using a visible light source, with antimicrobial activity at 0.03 μM with 10 s of irradiation by a 405 nm diode array (1.4 J/cm<sup>2</sup>); antimicrobial activity could also be achieved within minutes using a compact fluorescent lightbulb. GaPpIX was not only many times more potent than PpIX, a standard photosensitizer featured in clinical aPDI, but also demonstrated low cytotoxicity against HEK293 cells and human keratinocytes. Ga-PpIX uptake was screened against a diverse panel of bacterial pathogens using a fluorescence-based imaging assay, which revealed rapid uptake by several Gram-positive species known to express CSHRs, suggesting future candidates for targeted aPDT.
Design and applications of silicon waveguide grating couplers (2012)

We review our recent work on waveguide grating couplers, including an apodized grating coupler with engineered coupling strength to achieve Gaussian-like output profile, which greatly improves the fiber-chip coupling efficiency. We will also discuss a new class of grating couplers involving the use of sub-wavelength nanostructures to engineer the optical properties. Effective medium theory can be used in the design of sub-wavelength structures, which, when properly engineered, can offer broadband coupling and polarization independence. Other applications of waveguide gratings, for example bi-wavelength two dimensional gratings coupler for (de-)multiplexing two different wavelengths, fiber-waveguide hybrid lasers and mid-infrared grating couplers on silicon-on-sapphire wafer will also be briefly discussed.
On-Package Continuous-Time Linear Equalizer using Embedded Passive Components (2007)

Multi-gigabit input/output (I/O) links on printed circuit boards (PCBs) suffer from high-frequency signal attenuation, necessitating equalization to restore the transmitted waveforms. Whereas active transmitter or receiver equalization circuits consume significant power, equalizers composed exclusively of passive devices can achieve good signal integrity with no active power dissipation. Recent advances in packaging technology allow passive devices to be integrated directly into the substrate, thereby freeing area in the die or on the motherboard that would otherwise have been needed for the equalizer. In this paper, we are reporting the first, experimental demonstration of continuous-time linear equalizers (CTLEs) using embedded passive components up to 10 gigabit per second (Gbps). We have designed, optimized and fabricated three different equalizers using embedded passives technology. These devices were employed to a equalize board-level interconnect suffering from frequency-dependent loss. We have then validated the performance of the CTLEs in the frequency and time domains.
DTEF-1, a Novel Member of the Transcription Enhancer Factor-1 (TEF-1) Multigene Family (1996)

M-CAT motifs mediate muscle-specific transcriptional activity via interaction with binding factors that are antigenically and biochemically related to vertebrate transcription enhancer factor-1 (TEF-1), a member of the TEA/ATTS domain family of transcription factors. M-CAT binding activities present in cardiac and skeletal muscle tissues cannot be fully accounted for by existing cloned isoforms of TEF-1. TEF-1-related cDNAs isolated from heart libraries indicate that at least three classes of TEF-1-related cDNAs are expressed in these and other tissues. One class are homologues of the human TEF-1 originally cloned from HeLa cells (Xiao, J. H., Davidson, I., Matthes, H., Garnier, J. M., and Chambon, P. (1991) Cell 65, 551-568). A second class represents homologues of the avian TEF-1-related gene previously isolated (Stewart, A. F., Larkin, S. B., Farrance, I. K., Mar, J. H., Hall, D. E., and Ordahl, C. P. (1994) J. Biol. Chem. 269, 3147-3150). The third class consists of a novel, divergent TEF-1 cDNA, named DTEF-1, and its preliminary characterization is described here. Two isoforms of DTEF-1 (DTEF-1A and DTEF-1B) were isolated as 1.9-kilobase pair clones with putative open reading frames of 433 and 432 amino acids whose differences are attributable to alternative splicing at the C terminus of the TEA DNA binding domain. Cardiac muscle contains high levels of DTEF-1 transcripts, but unexpectedly low levels are detected in skeletal muscle. DTEF-1 transcripts are present at intermediate levels in gizzard and lung, and at low levels in kidney. DTEF-1A is a sequence-specific M-CAT-binding factor. The distinct spatial pattern of expression, and unusual amino acid sequence in its DNA binding domain, may indicate a particular role for DTEF-1 in cell-specific gene regulation. Recent work also suggests that at least one more TEF-1-related gene exists in vertebrates. We propose a naming system for the four TEF-1 gene family members identified to date that preserves existing nomenclature and provides a means for extending that nomenclature as additional family members may be identified.
Waveform Optimization for Improving Inkjet Printing Speed (2023)

Abstract Inkjet has been widely used in different industrial applications for its high resolution and capability to print with multiple materials, but its printing speed has limited its use for high volume production. This paper presents a new approach to improve the speed of piezo inkjet printing through waveform optimization. We previously developed a model that can predict the effects of driving signal parameters on printing speed, and in this paper, we use optimization techniques to find the optimal signal parameters for maximum speed. We then validate these optimal parameters using a custom-designed experimental setup with a high-speed camera capable of capturing the dynamics of droplet formation. Our results show that our optimized signal achieves successful jetting with a five-time increase in equivalent printing speed compared to a benchmark commercial printhead (Xaar 128/80W).
A frequency tunable embedded normal-mode helix antenna for portable wireless devices (2011)

A frequency tunable normal mode helical antenna is presented for wireless mobile handsets. This antenna is placed across the width of the handset chassis, which is considered as part of the radiating structure. It is shown that by keeping the length of the helix antenna constant and varying the pitch angle (height) of the antenna, the frequency of operation can be tuned to switch between various frequency bands to cover all standard 3G and 4G bands required for the next generation of mobile handsets. Variation of the helix pitch angle is implemented using a shape memory alloy (SMA) spring placed in parallel with the antenna. Extraction and contraction of this spring and therefore the antenna is controlled by passing a DC current through it. FIT simulation results (CST™) are presented for the tunable helix antenna with the SMA spring effect included in the model. Antenna design criteria are also discussed.
Formation of formic acid from glycerine using a hydrothermal reaction (2012)

Abstract BACKGROUND: Glycerine, a main by‐product of the biodiesel manufacturing process, has potential to be an important biorefinery feedstock with the rapid increase in biodiesel production all over the world. Hydrothermal experiments with glycerine were carried out at 250 °C using H 2 O 2 as an oxidant. RESULTS: Glycerine was converted into formic acid with a yield of 31.0% based on the starting mass of carbon in glycerine. A possible oxidation pathway for the formation of formic acid from glycerine is proposed. In the proposed pathway, glycerine may first be oxidised and then decomposed into formic acid and oxalic acid. Oxalic acid was indirectly attributed to the increase of formic acid production from glycerine, but it instead acts as a retardant to prevent further oxidation of formic acid. However, when an alkali was added to the experimental conditions, the yield of formic acid was not greatly improved, reaching only 34.7%. CONCLUSION: The present work should help to facilitate further studies to develop a new green process for the production of formic acid from renewable biomass. © 2012 Society of Chemical Industry
A Real-Time Automated Visual Inspection System for Hot Steel Slabs (1983)

This paper describes an inspection system designed to automatically detect and classify surface imperfections occurring on continuously cast hot steel slabs in a steel mill. The need to perform inspection at real-time throughput rates of 546 Kpixels/s using off-the-shelf components has led to the development of a unique architecture and algorithm set. The segmentation operations are done in a high-speed array processor front end. The imperfection classification is done in a mini-computer which uses statistical as well as syntactic/semantic classification techniques. The inspection system is currently undergoing evaluation in a steel mill.
Characterizing PV Arcing Conditions with Impedance Spectroscopy and Frequency Response Analysis (2011)

Photovoltaic arc faults have led to a number of rooftop fires that have caused significant property damage and threatened the safety of building occupants. In response, Article 690.11 was added to the United States 2011 National Electrical Code, requiring new PV systems on or penetrating a building to include a listed arc fault protection device. Many proposed arc fault detectors utilize frequency content on the PV string to remotely determine if an arc fault is occurring. A frequency response analyzer was used to measure the AC frequency and impedance response of an 80 W polycrystalline module with degradation similar to those which have caused arc fault. The module had intermittent electrical connectivity in the junction box because of a failed solder bond, and the quality of the connection could be manipulated by adjusting the external wire orientation. By reorienting the wire, the impedance profile changed and the frequency response transitioned between high-pass, low-pass, and no filtering behavior. This indicated (1) certain module conditions can filter arc fault noise frequencies, and (2) the frequency response or impedance spectroscopy of PV components could be used to identify conditions that cause arc faults in PV systems. The implications for the former are serious because if the detection frequencies used by the fault circuit interrupter (AFCI) are sufficiently filtered, the device will not trip and the arc will not be extinguished. Finally, infrared images were taken of the intermittent module to identify the area of damage and corroborate the impedance spectroscopy results.
A monolithic fully-integrated vacuum-sealed CMOS pressure sensor (2002)

This paper presents an integrated multitransducer capacitive barometric pressure sensor that is vacuum-sealed at wafer level. The interface circuitry is integrated directly within the sealed reference cavity, making the device immune to parasitic environmental effects. The overall device process merges BiCMOS circuitry with a dissolved wafer transducer process, is compatible with bulk- and surface-micromachining, and employs chemical mechanical polishing (CMP), anodic bonding, and hermetic lead transfers. The sensor achieves 15b resolution and is suitable for low-cost packaging. The device is composed of a programmable switched capacitor readout circuit, five segmented-range pressure transducers, and a reference capacitor, all integrated on a 7.5/spl times/6.5 mm/sup 2/ die using 3 /spl mu/m features.
Three-phase active power filters with unified constant-frequency integration control (2002)

In this paper, a unified constant-frequency integration (UCI) control method for a three-phase active power filter (APF) is proposed. The proposed control method eliminates the need of sensing the three-phase load current, the nontrivial task of calculating the harmonics and reactive current components, as well as the use of any multipliers, as required by previously reported control methods. By applying one-cycle control and sensing the mains line current, unity power factor and low input current distortion can be realized by one integrator with reset along with a few linear components such as flip-flops, comparators and clock. The proposed controller is simple, robust, and reliable. All findings are supported by simulation and experiments.
Distributed and collaborative Web Change Detection system (2014)

Search engines use crawlers to traverse the Web in order to download web pages and build their indexes. Maintaining these indexes up-to-date is an essential task to ensure the quality of search results. However, changes in web pages are unpredictable. Identifying the moment when a web page changes as soon as possible and with minimal computational cost is a major challenge. In this article we present the Web Change Detection system that, in a best case scenario, is capable to detect, almost in real time, when a web page changes. In a worst case scenario, it will require, on average, 12 minutes to detect a change on a low PageRank web site and about one minute on a web site with high PageRank. Meanwhile, current search engines require more than a day, on average, to detect a modification in a web page (in both cases).
Electrophoretic karyotyping of yeasts, and southern blotting using whole chromosomes as templates for the probe preparation. (1992)

The technique of Contour-clamped Homogenous Electric Field (CHEF) gel electrophoresis has been used to separate intact chromosomal DNA of different species of the yeast genera Saccharomyces and Zygosaccharomyces. Various strains of the same species had similar chromosomal band patterns. However, differences between individual bands indicated that strain-specific chromosome length polymorphism is common in these organisms.To test conspecificity, a new, DNA-DNA hybridization technique was developed using individual whole chromosomes as templates to prepare randomly primed, radioactive probes. Under our conditions of stringency, species-specific hybridization reactions were achieved with these probes. The method is an efficient tool to study the genetic diversity of a given yeast species. Also, it can assist yeast species identification.
Robust Low-Loss Multimaterial Chalcogenide Fiber for Infrared Applications fabricated by a Hybridized approach (2016)

A two-step approach to produce robust chalcogenide fibers with < 1 dB/m loss across the infrared is introduced. The new approach consists of double-crucible cane fabrication of highly purified chalcogenide-glass combined with multimaterial thermal fiber drawing.
Graphene oxide/metal nanocrystal multilaminates as the atomic limit for safe and selective hydrogen storage (2016)

Abstract Interest in hydrogen fuel is growing for automotive applications; however, safe, dense, solid-state hydrogen storage remains a formidable scientific challenge. Metal hydrides offer ample storage capacity and do not require cryogens or exceedingly high pressures for operation. However, hydrides have largely been abandoned because of oxidative instability and sluggish kinetics. We report a new, environmentally stable hydrogen storage material constructed of Mg nanocrystals encapsulated by atomically thin and gas-selective reduced graphene oxide (rGO) sheets. This material, protected from oxygen and moisture by the rGO layers, exhibits exceptionally dense hydrogen storage (6.5 wt% and 0.105 kg H 2 per litre in the total composite). As rGO is atomically thin, this approach minimizes inactive mass in the composite, while also providing a kinetic enhancement to hydrogen sorption performance. These multilaminates of rGO-Mg are able to deliver exceptionally dense hydrogen storage and provide a material platform for harnessing the attributes of sensitive nanomaterials in demanding environments.
Structure-antitumor Activity Relationship of Semi-synthetic Spicamycin Derivatives. (1995)

New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.
Antibody-based therapeutics against components of the IGF system (2012)

The insulin-like growth factor I (IGF-I) receptor (IGF-1R) is overexpressed in most human neoplasms tested so far. Many tumors in young patients produce high levels of the IGF-1R ligands, IGF-I and IGF-II. Given the complexity of the IGF signaling pathway, its complete inhibition may require combination therapies with antibodies targeting both IGF-1R and IGF-II.
Ontology-based user requirements decomposition for component selection for highly available systems (2014)

To meet user requirements, Commercial-off-the-Shelf (COTS) component based systems are built by integrating different components potentially provided by different vendors. The gap between the user requirements, related to the overall system, and the available components could be very large. Thus the selection of appropriate components for building the system becomes a difficult task. In this paper, we propose an approach to close this gap in the context of highly available systems to be deployed on a Service Availability Forum (SAForum) compliant middleware. Our approach decomposes the user requirements into lower level requirements, referred to as configuration requirements with the help of an ontology. It is a model based approach, which consists of three metamodels and the necessary transformations including traceability links between user requirements and a solution to facilitate system evolution and maintainability.
Low-temperature chemical vapor deposition of SiO2 at 2–10 Torr (1987)

We discuss a new low-pressure and low-temperature process for the chemical vapor deposition (CVD) of silicon dioxide. The process differs from conventional low-pressure CVD in that lower temperatures (150–300 °C) and a unique pressure window (2–10 Torr) provide the conditions for the reaction of silane (SiH4) and oxygen. In this thermal process, activation energies of 0.15–0.18 eV and deposition rates of 100 Å/min at 250 °C are achieved. This technique is approximately 15 times less sensitive to the O2:SiH4 ratio than atmospheric pressure CVD. The deposition conditions are compatible with both low-temperature silicon and III-V technologies. Preliminary current-voltage and capacitance-voltage measurements on Si indicate dielectric field strength of 3–8×106 V/cm and fixed oxide charge density (Qss) less than 1011 cm−2.