gebhart/patrepeval huggingface dataset:
Photochemical behavior assessment of sunscreen preparations by <i>in vitro </i>UV spectroscopy (2004)

In this study, we used a spectroscopic method, found effective in measuring sunscreen photo‐degradation results in terms of a photoabsorption decrease. The traditional approach was to measure variations in well‐known parameters such as the absolute in vitro sun protection factor (SPF) or the relative UVA/UVB ratio after a controlled dose of UV radiation. However, these parameters fail to fully reflect the product's photochemical behavior. Variation in the SPF mainly depicts changes in UVB filtration, and variation in the relative parameter UVA/UVB ratio can be subjected to misinterpretation, as is the case for products in which a parallel loss of photoabsorption is observed in the UVA and UVB regions. In our laboratory, we developed a new approach using pure spectroscopic UVA and UVB attenuation factors called UVA attenuation factor and UVB attenuation factor. Attenuation factors are defined here as the inverse of the arithmetic mean of the transmittance data, taken either from the UVB region (290–320 nm, 1 nm steps) or the UVA region (320–400 nm, 1 nm steps). Using these two new spectroscopic indices, the photochemical behavior of a sunscreen formula can be assessed in each UV region. The general procedure consists of applying two UV doses to a film of sunscreen previously spread on a roughened polymethylmethacrylate plate and then measuring the UV transmission versus wavelength before and after the irradiation process. We tested different UV filters in a cosmetic base to demonstrate the efficacy of the method.
Rotational Isomers of <i>N</i>-Alkylpyridylporphyrins and Their Metal Complexes. HPLC Separation, <sup>1</sup>H NMR and X-ray Structural Characterization, Electrochemistry, and Catalysis of O<sub>2</sub><sup>•</sup><sup>-</sup> Disproportionation (2002)

Rotational (atropo-) isomers of Mn(III) meso-tetrakis(N-alkylpyridinium-2-yl)porphyrins and corresponding metal-free porphyrin ligands (where alkyl is methyl, ethyl, n-butyl, n-hexyl) and Zn(II) meso-tetrakis(N-methyl(ethyl,n-hexyl)pyridinium-2-yl)porphyrins were separated and isolated by reverse-phase HPLC. The identity of the rotational isomers of metal-free meso-tetrakis(N-methylpyridinium-2-yl)porphyrin was established by 1H NMR spectra and by the crystal structure of the fastest eluting fraction (Rf = 7.7%, Rw = 9.2%, P21/c, Z = 8, a = 14.2846(15) Å, b = 22.2158(24) Å, c = 29.369(3) Å, β = 95.374(2)°) which, in accordance with 1H NMR interpretation, proved to be the αβαβ isomer. This result, together with elution intensity patterns, was used to identify the fractions of other Mn(III)-porphyrins, Zn(II)-porphyrins, and corresponding metal-free ligands in the series. All of the atropoisomers were inert toward isomerization which was not observable for 30 days at room temperature and reached only 50% in 16 days at 90 °C in the case of the Mn(III)-ethyl analogue. However, a complete freeze-dry removal of the mobile phase from the HPLC fractions caused an almost 100% isomerization. The Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, as a mixture of atropoisomers (AEOL-10113), has been shown to offer protection in oxidative stress injury ascribed to its high reactivity toward superoxide (kcat = 5.8 × 107 M-1 s-1) as a consequence of its favorable redox potential (E1/2 = +228 mV vs NHE). In this work, the atropoisomers were found to have similar redox potentials ranging from +240 to +220 mV, to be similarly potent catalysts of O2•- disproportionation (dismutation), with kcat ranging from 5.5 × 107 to 6.8 × 107 M-1 s-1, and not to preferentially bind to biological tissue.
Analysis of the Structure and Expression of the Human Dopamine D2<sub>A</sub> Receptor Gene (1991)

In order to study the possible involvement of dopamine receptors in the pathophysiology of various neurological and psychiatric disorders, we have isolated the human D2A gene. Like the rat D2A gene, the human gene contains at least eight exons and spans at least 52 kb. Exons 2-8 are clustered within 14 kb of genome. Exon 1 is separated from exon 2 by at least 38 kb. We and others have shown that alternative utilization of exon 6 gives rise to alternative D2A transcripts. Despite the extreme size of intron 1, no alternative transcription between exons 1 and 2 can be detected in basal ganglia and pituitary using polymerase chain reaction analysis. The relative abundance and tissue distribution of the alternative D2A transcripts were examined in 18 human brain regions. The relative expression of the transcripts varied by at least 70-fold across the brain regions surveyed. As expected, high levels of transcripts were detected in caudate, putamen, and pituitary. Moderate levels were detected in regions of catecholamine-containing cell bodies and in the amygdala. In contrast to the rat brain, very low levels of transcripts were detected in cortical regions.
Electrode Location and Angular Insertion Depth Are Predictors of Audiologic Outcomes in Cochlear Implantation (2016)

Electrode design and surgical approach were predictors of scalar electrode location. Specifically, LW electrodes showed higher rates of ST insertion compared with PM or MS. RW and ERW approaches showed higher rates of ST insertion when compared with C. In regards to performance, ST insertion, younger age, and greater angular insertion depth were predictors of improved CNC scores.
Spectrally selective <i>B</i><sub>1</sub>‐insensitive <i>T</i><sub>2</sub> magnetization preparation sequence (2009)

A T(2) magnetization-preparation (T(2) Prep) sequence is proposed that is insensitive to B(1) field variations and simultaneously provides fat suppression without any further increase in specific absorption rate (SAR). Increased B(1) inhomogeneity at higher magnetic field strength (B(0) > or = 3T) necessitates a preparation sequence that is less sensitive to B(1) variations. For the proposed technique, T(2) weighting in the image is achieved using a segmented B(1)-insensitive rotation (BIR-4) adiabatic pulse by inserting two equally long delays, one after the initial reverse adiabatic half passage (AHP), and the other before the final AHP segment of a BIR-4 pulse. This sequence yields T(2) weighting with both B(1) and B(0) insensitivity. To simultaneously suppress fat signal (at the cost of B(0) insensitivity), the second delay is prolonged so that fat accumulates additional phase due to its chemical shift. Numerical simulations as well as phantom and in vivo image acquisitions were performed to show the efficacy of the proposed technique.
Two-wave-plate compensator method for full-field retardation measurements (2006)

The two-wave-plate compensator (TWC) method is expanded for full-field retardation measurements by use of a polarization microscope. The sample image is projected onto a CCD camera connected to a computer, allowing the retardation to be measured at all pixels. The retardation accuracy of this implementation of the TWC is evaluated to be 0.06 nm. The method is applied to polarization-maintaining fibers and long-period fiber gratings. The measured retardation is in good agreement with the crossed-polarizer images of the fibers. The method achieves a spatial resolution of 0.45 microm and a retardation resolution of 0.07 nm. The full-field TWC method can thus be a useful tool for characterizing and monitoring the fabrication of optical devices.
Advances in deep learning approaches for image tagging (2017)

jianlong fu and yong
Single-dose pharmacokinetic study of rapidly dispersing diclofenac potassium formulations in healthy volunteers (2009)

These data show that diclofenac potassium formulations using proprietary dispersion technology are rapidly and consistently absorbed. These characteristics may be beneficial in settings where rapid and consistent drug absorption is desirable. These results may differ in other patient populations such as those experiencing pain or illness.
The feasibility of rabies virus-vectored immunocontraception in a mouse model (2013)

Immunocontraceptive vaccines may be an alternative to surgical sterilization. Dual rabies vaccination and dog population management is a helpful tool for rabies prevention. A synthetic gonadotropin-releasing hormone (GnRH) peptide coupled to a carrier protein or T cell epitope is efficacious in inducing immunocontraception in a variety of mammals. However, virus-vectored GnRH recombinant vaccines have advantages over the conjugation method. In a previous in vitro study, we were able to insert a GnRH-coding sequence into the rabies virus (RABV) glycoprotein (G) gene, and the recombinant viruses grew to high titers in cells. Here, we further focused on the RABV G in accepting various copy numbers of GnRH. We demonstrated although RABV G protein with up to 4 copies of GnRH was well expressed, the recombinant virus was recovered only when 2 copies of GnRH (20 amino acids) were incorporated into the G, indicating a possible insertion limit in making a full infectious clone. The investigation provides insight into the utility of RABV G as a carrier for small peptides and its suitability for vaccine studies. Following our previous study, we selected ERAg3p/2GnRH and tested the construct in mice. The vaccine induced ⩾80% infertility after three doses without any adjuvant, in live (8 of 10 mice infertility) or inactivated (13 of 14 mice infertility) formulations; while the pregnancy rate was 100% (10 of 10 mice) in the controls. This initial success of immunocontraception in mice is promising, and we are now optimizing the vaccine formulation by using adjuvants and exploring novel delivery methods to minimize the dosage.
FLightNNs (2019)

To improve the throughput and energy efficiency of Deep Neural Networks (DNNs) on customized hardware, lightweight neural networks constrain the weights of DNNs to be a limited combination (denoted as k ϵ {1, 2}) of powers of 2. In such networks, the multiply-accumulate operation can be replaced with a single shift operation, or two shifts and an add operation. To provide even more design flexibility, the k for each convolutional filter can be optimally chosen instead of being fixed for every filter. In this paper, we formulate the selection of k to be differentiable, and describe model training for determining k-based weights on a per-filter basis. Over 46 FPGA-design experiments involving eight configurations and four data sets reveal that lightweight neural networks with a flexible k value (dubbed FLightNNs) fully utilize the hardware resources on Field Programmable Gate Arrays (FPGAs), our experimental results show that FLightNNs can achieve 2× speedup when compared to lightweight NNs with k = 2, with only 0.1% accuracy degradation. Compared to a 4-bit fixed-point quantization, FLightNNs achieve higher accuracy and up to 2× inference speedup, due to their lightweight shift operations. In addition, our experiments also demonstrate that FLightNNs can achieve higher computational energy efficiency for ASIC implementation.
/spl Sigma/High-frequency LC VCO design using capacitive degeneration (2004)

In this paper, we evaluate the high-frequency performance limitations of traditional LC voltage-controlled oscillators (VCOs) that use a cross-coupled negative resistance cell and propose a new topology that overcomes these limitations. The proposed cell is based on a capacitively emitter degenerated topology which uses a cross-coupled MOS pair as the degeneration cell. The cross-coupled MOS pair contributes additional conductance and results in a higher maximum attainable oscillation frequency and better negative resistance characteristics as compared to the other topologies at high frequencies. These properties combined with its small effective capacitance enable low-power low-noise high-frequency VCO implementations. The proposed topology is demonstrated through a 20-GHz fully integrated LC VCO implemented in the IBM SiGe 0.25-/spl mu/m BiCMOS process. A comparison of its figure of merit with previously reported 20-GHz VCOs shows the effectiveness of the proposed topology.
Wide-field fluorescent microscopy on a cell-phone (2011)

We demonstrate wide-field fluorescent imaging on a cell-phone, using compact and cost-effective optical components that are mechanically attached to the existing camera unit of the cell-phone. Battery powered light-emitting diodes (LEDs) are used to side-pump the sample of interest using butt-coupling. The pump light is guided within the sample cuvette to excite the specimen uniformly. The fluorescent emission from the sample is then imaged with an additional lens that is put in front of the existing lens of the cell-phone camera. Because the excitation occurs through guided waves that propagate perpendicular to the detection path, an inexpensive plastic color filter is sufficient to create the dark-field background needed for fluorescent imaging. The imaging performance of this light-weight platform (~28 grams) is characterized with red and green fluorescent microbeads, achieving an imaging field-of-view of ~81 mm(2) and a spatial resolution of ~10 μm, which is enhanced through digital processing of the captured cell-phone images using compressive sampling based sparse signal recovery. We demonstrate the performance of this cell-phone fluorescent microscope by imaging labeled white-blood cells separated from whole blood samples as well as water-borne pathogenic protozoan parasites such as Giardia Lamblia cysts.
Directed Evolution of AAV Targeting Primate Retina by Intravitreal Injection Identifies R100, a Variant Demonstrating Robust Gene Delivery and Therapeutic Efficacy in Non-Human Primates (2021)

Abstract Targeted AAV vectors are needed for safe and efficient delivery to and transduction of specific tissue target(s) in patients. Effective intravitreal delivery for retina gene therapy is not feasible with wildtype AAV. We employed directed evolution in nonhuman primates (NHP) to discover an AAV variant (R100) for intravitreal treatment of multiple target cells in the primate retina. R100 demonstrated superior transduction of human retinal cells compared to wildtype AAV. Furthermore, three R100-based gene therapeutics demonstrated safety, delivery, and durable pan-retinal expression of intracellular or secreted transgenes throughout the NHP retina following intravitreal administration. Finally, efficacy of R100-mediated delivery of therapeutic transgenes was demonstrated in patient-derived retinal cells (monogenic diseases) and in an NHP model of pathogenic retinal angiogenesis.
Compound eye systems for nonunity magnification projection (1990)

New compound eye systems for nonunity magnification projection are shown. As all the beams of light on the optical axes of erect or inverted real image systems intersect perpendicular to the object and image planes in these systems, it becomes possible to get rid of any local variation in magnification, which deteriorates the image quality of earlier compound eye systems.
Diffraction Based Biosensing with Porous Silicon (2010)

We present a highly sensitive porous silicon diffraction grating for biosensing applications. The gratings are fabricated using a cost-effective, high-throughput stamping technique. Small molecule detection is demonstrated.
Sensitive and Simple Frequency Comb Fourier Transform Spectrometer with a Multipass Cell (2010)

Multipass cells offer a simple manner to enhance the sensitivity of dual-comb Fourier transform spectrometer. 1.5 µm spectra spanning 125 nm and exhibiting a noise-equivalent absorption coefficient of 4·10−9 cm−1Hz−1/2 are recorded within 63 µs.
Random oracles in constantipole (2000)

Byzantine agreement requires a set of parties in a distributed system to agree on a value even if some parties are corrupted. A new protocol for Byzantine agreement in a completely asynchronous network is presented that makes use of cryptography, specifically of threshold signatures and coin-tossing protocols. These cryptographic protocols have practical and provably secure implementations in the “random oracle” model. In particular, a coin-tossing protocol based on the Diffie-Hellman problem is presented and analyzed.
Experimental comparison of a liquid-crystal point-diffraction interferometer (LCPDI) and a commercial phase-shifting interferometer and methods to improve LCPDI accuracy (2002)

We compare the phase measurements of a fused-silica witness sample made with a liquid-crystal point-diffraction interferometer (LCPDI) with measurements made with a Zygo Mark IV xp phase-shifting interferometer and find close agreement. Two phase-shift-error sources in the LCPDI that contribute to measurement discrepancies are frame-to-frame intensity changes caused by the dichroism of the dye and alignment distortions of the host liquid crystal. An empirical model of the phase-shift error caused by the host alignment distortions is presented and used to investigate the performance of two different phase-detection algorithms. It is suggested that by proper choice of LCPDI fabrication parameters and phase-acquisition methods, the device's accuracy can be significantly improved.
Method for Improving Natural Gas Energy Density at Ambient Temperatures (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethod for Improving Natural Gas Energy Density at Ambient TemperaturesK. E. Starling, E. R. Ding, J. H. Harwell, and R. G. MallinsonCite this: Energy Fuels 1995, 9, 6, 1062–1064Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ef00054a020https://doi.org/10.1021/ef00054a020research-articleACS PublicationsRequest reuse permissionsArticle Views221Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dynamic XML-based exchange of relational data: application to the Human Brain Project. (2003)

This paper discusses an approach to exporting relational data in XML format for data exchange over the web. We describe the first real-world application of SilkRoute, a middleware program that dynamically converts existing relational data to a user-defined XML DTD. The application, called XBrain, wraps SilkRoute in a Java Server Pages framework, thus permitting a web-based XQuery interface to a legacy relational database. The application is demonstrated as a query interface to the University of Washington Brain Project's Language Map Experiment Management System, which is used to manage data about language organization in the brain.
Microinjection in a microfluidic format using flexible and compliant channels and electroosmotic dosage control (2009)

We present a novel PDMS-based microinjection system in a microfluidic format with precise electroosmotic dosage control. The device architecture is fully scalable and enables high-throughput microinjections with integrated pre- and post-processing operations. The injection mechanism greatly simplifies current methods as only a single degree of freedom is required for injections. The injections are performed inside a fully enclosed channel by an integrated microneedle. Actuation of the needle is achieved by the compliant deformation of the channel structure by an external actuator. Reagent transport is achieved using electroosmotic flow (EOF) which provides non-pulsating flow and precise electrical dosage control. The potentials used for injections were between 5 V-25 V. The electrical properties and flow rates for the device were characterized for Zebrafish embryos and Rhodamine B and Methylene blue in pH 10 buffer solution. We also propose a method to enable precise individual dosing of embryos using direct electrical feedback. Additionally, we show that electrical feedback can be used to verify the location of the needle inside the injection target. A preliminary viability study of our device was conducted using Zebrafish (Danio rerio) embryos. The study involved the injection of ultrapure water into the embryos in an E3 buffer, and resulted in embryos that showed normal development at 48 hours.
An Integrated Four-Element Slot-Based MIMO and a UWB Sensing Antenna System for CR Platforms (2017)

This communication presents a novel integrated antenna system for cognitive radio (CR) applications. The design consists of a compact four-element reconfigurable annular slot-based multiple-input-multiple-output (MIMO) antenna system integrated within an ultrawideband (UWB) sensing antenna. All the antenna elements are planar in structure and designed on a single substrate (RO-4350) with dimensions $60\times 120\times 1.5$ mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> . The frequency reconfigurable slot-based MIMO antenna system is tuned over a wide frequency band from 1.77 to 2.51 GHz while the UWB sensing antenna is covering from 0.75 to 7.65 GHz The proposed antenna system is suitable for CR enabled wireless devices. The envelop correlation coefficient did not exceed 0.248 in the entire operating band of the MIMO antenna part. The maximum measured gain of the MIMO antenna is 3.2 dBi with a maximum efficiency of 81%.
Synthesis and Biological Evaluation of Novel Cyclosporin A Analogues:  Potential Soft Drugs for the Treatment of Autoimmune Diseases (2003)

Cyclosporin A is effective in the treatment of asthma patients, but its chronic use is limited by toxicity. Novel cyclosporin A analogues were synthesized utilizing the olefin metathesis reaction and evaluated in a calcineurin A inhibition assay. The novel analogues demonstrated activity comparable to activity of the parent molecule and are potential soft drugs.
Learning from Neighboring Strokes: Combining Appearance and Context for Multi-Domain Sketch Recognition (2009)

We propose a new sketch recognition framework that combines a rich representation of low level visual appearance with a graphical model for capturing high level relationships between symbols. This joint model of appearance and context allows our framework to be less sensitive to noise and drawing variations, improving accuracy and robustness. The result is a recognizer that is better able to handle the wide range of drawing styles found in messy freehand sketches. We evaluate our work on two real-world domains, molecular diagrams and electrical circuit diagrams, and show that our combined approach significantly improves recognition performance. 1