gebhart/patrepeval huggingface dataset:
Prospective neuroimaging study in hereditary spastic paraplegia with thin corpus callosum (2007)

Our objective was to estimate the frequency as well as to establish the clinical and neuroimaging profile of hereditary spastic paraplegia with thin corpus callosum (HSP-TCC). HSP-TCC was recognized as a specific clinical subtype of HSP and mapped to chromosome (ch) 15q13-15 in Japanese families. It has been considered rare in western countries. We assessed 45 patients with autosomal recessive HSP from 20 different families in search of clinical and imaging criteria for the diagnosis of HSP-TCC. In addition, HSP-TCC patients underwent further neurological, imaging and genetic evaluation. MRI scans were performed in a 2T scanner and sagittal T1 weighted images used for semiautomated volumetric measurements of corpus callosum, cerebellum, and brain. In seven patients, a 2-year follow-up MRI scan was performed. We genotyped seven microsatellite markers flanking the 15q13-15 candidate region and calculated two-point and multipoint LOD scores (Z). We identified 13 patients from seven unrelated families with HSP-TCC. MRI showed significant corpus callosum, cerebral and cerebellar volumetric reductions (P<0.001, P=0.03, and P=0.01, respectively). In the prospective analysis, we found progressive corpus callosum atrophy (P=0.04). Two-point and multipoint LOD scores were significantly negative for markers genotyped on ch 15q. However, independent pedigree analysis did not yield significant results. HSP-TCC was found in 35% of families with autosomal recessive HSP. MRI volumetry showed cerebral and cerebellar atrophy in association with progressive corpus callosum thinning. Genetic studies did not show evidence for linkage to ch 15q.
Silencing MicroRNA-155 Ameliorates Experimental Autoimmune Encephalomyelitis (2011)

IFN-γ-producing Th1 and IL-17-producing Th17 cells are the key participants in various autoimmune diseases, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Although both of these T cell subsets are known to be regulated by specific transcription factors and cytokines, the role of microRNAs that control these two inflammatory T cell subsets and whether targeting microRNAs can have therapeutic effects are not known. In this study, we show that microRNA-155 (Mir-155) expression is elevated in CD4(+) T cells during EAE, and Mir-155(-/-) mice had a delayed course and reduced severity of disease and less inflammation in the CNS. The attenuation of EAE in Mir-155(-/-) mice was associated with a decrease in Th1 and Th17 responses in the CNS and peripheral lymphoid organs. The T cell-intrinsic function of Mir-155(-/-) was demonstrated by the resistance of Mir-155(-/-) CD4(+) T cell-repleted Rag-1(-/-) mice to EAE. Finally, we found that anti-Mir-155 treatment reduced clinical severity of EAE when given before and after the appearance of clinical symptoms. These findings demonstrate that Mir-155 confers susceptibility to EAE by affecting inflammatory T cell responses and identify Mir-155 as a new target for therapeutic intervention in multiple sclerosis.
Fabrication and Electrical and Mechanical Properties of Carbon Nanotube Interconnections (2005)

Abstract Individual carbon nanotubes (CNTs) have been cut, manipulated, and soldered via electron‐beam‐induced deposition of amorphous carbon (a‐C) and using a scanning tunneling microscope inside a transmission electron microscope. All CNT structures, including simple tube–tube connections, crossed junctions, T‐junctions, zigzag structures, and even nanotube networks, have been successfully constructed with a high degree of control, and their electrical and mechanical properties have been measured in situ inside the transmission electron microscope. It is found that multiple CNTs may be readily soldered together with moderate junction resistance and excellent mechanical resilience and strength, and the junction resistance may be further reduced by current‐induced graphitization of the deposited a‐C on the junction.
Direct N8-alkylation of 2,4-diamino-7,8-dihydropteridines. Preparation of 7,8-dihydro-8-methylmethotrexate (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect N8-alkylation of 2,4-diamino-7,8-dihydropteridines. Preparation of 7,8-dihydro-8-methylmethotrexateMichael ChaykovskyCite this: J. Org. Chem. 1975, 40, 1, 145–146Publication Date (Print):January 1, 1975Publication History Published online1 May 2002Published inissue 1 January 1975https://pubs.acs.org/doi/10.1021/jo00889a046https://doi.org/10.1021/jo00889a046research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biomarkers of Aging (2001)

As a subgenre of biogerontology, biomarker research has developed a thoroughly tarnished reputation, and those who believe that biomarker studies should be a major focus in experimental aging research must now try to prove to their doubting colleagues that under the tarnish lies true metal, rather than more layers of tarnish. In this Perspective, the author argues that the discovery of biomarkers of aging is possible.
Social Innovation in Health Care (2016)

For this deliverable we investigated the recovery approach in mental health across four European countries. The recovery approach was chosen as it is an important driver of the social model of disability which was the area that this work package on health focused on. Our analysis covers two parts: First, we examined the role of individuals and organisations (so called actors) over time and identified important milestones (legislation, policies, events, publications); this also covered an analysis of ‘dynamics’ i.e. interactions between actors from different sector, how the recovery approach related to the life cycle of an innovation, and how those dynamics could be analysed in the context of different welfare state regimes (Esping-Anderson’s typology of decommodification and stratification). Next, in a second part, we analysed the characteristics of organisations, which had been identified as driving and implementing the recovery approach in each of the four countries. Characteristics had been linked in the literature to organisation’s ability to innovative (‘hypothesis testing’). We summarized findings based on two parts of the analysis deriving some commonalities and important differences between countries in regards the existence of the recovery approach.
MOLECULAR MAGIC WITH MICROWAVES (1997)

RETURN TO ISSUEPREVNewsNEXTMOLECULAR MAGIC WITH MICROWAVESScientists are discovering new ways to use microwaves in organic synthesis, materials processing, waste remediationRON DAGANIView Author Information C&EN WashingtonCite this: Chem. Eng. News 1997, 75, 6, 26–33Publication Date (Print):February 10, 1997Publication History Published online12 November 2010Published inissue 10 February 1997https://pubs.acs.org/doi/10.1021/cen-v075n006.p026https://doi.org/10.1021/cen-v075n006.p026newsACS PublicationsCopyright © 1997 AMERICAN CHEMICAL SOCIETYArticle Views18Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Computational chemistry,Electromagnetic radiation Get e-Alerts
The failure of McEliece PKC based on Reed-Muller codes. (2013)

This paper describes new algorithm for breaking McEliece cryptosystem, built on Reed-Muller binary code RM(r, m), which receives the private key from the public key. The algorithm has complexity O(n d +n 4 log2n) bit operations, where n = 2 m, d = GCD(r, m−1). In the case of GCD(r, m − 1) limitation, attack has polynomial complexity. Practical results of implementation show that McEliece cryptosystems, based on the code with length n = 65536 bits, can be broken in less than 7 hours on a personal computer. 1
ChemInform Abstract: ANTIIMPLANTATION AGENTS: PART II ‐ 1,2‐DIARYL‐1,2,3,4‐TETRAHYDROISOQUINOLINES (1985)

Abstract Aus den Phenylessigsäureaniliden (I) werden über die Amide (II) die Diaryl‐tetrahydroisochinoline (III) hergestellt, die ebenso wie eine Reihe ähnlicher Verbindungen wie (lW‐(VII) werden (zum Teil IR‐.
Efficient 494-mW Sum-frequency Generation of 589-nm Light by Using a Periodically Poled LiNbO<inf>3</inf> Ridge Waveguide (2009)

Sodium atoms have long played an important role in spectroscopy and in the study of degenerate quantum gases. Since there are no appropriate solid-state lasers for generating continuous wave 589 nm light, which corresponds to the sodium doublet, dye lasers have mainly been used. These lasers have a problem as regards stability and their operation requires daily maintenance. Recently, it has been proposed to replace the dye laser with the sum-frequency generation (SFG) of two Nd:YAG lasers at 1064 and 1319 nm [1]. However, a doubly resonant enhancement cavity with a complex feedback locking system had to be used in order to obtain a good conversion efficiency. In this report, by using a periodically poled LiNbO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> (PPLN) ridge waveguide [2] for the SFG, a high conversion efficiency to 589 nm light is obtained solely with a simple single pass wavelength conversion process without using an enhancement cavity.
Frechet Cascade Stress-Strength System Reliability (2017)

In this paper it has been discussed the reliability of n- cascade system when the stress and strength are Frechet distributed random variables. The n-Cascade system is a standby redundancy system, where the standby component taking the place of failed component with decreased value of stress and independently distributed strength. Cascade reliability model is a special type of Stress- Strength model. For n=2,3,4 as Marginal Reliabilities, The values of Marginal Reliabilities used to find the system Reliabilities R 2 , R 3 and R 4 of Cascade model, which studied for this model in different cases for the parameters of this distribution according to the Cascade variables. These cases are 12 special cases and the values of R 2 , R 3 and R 4 are discussed for each of these cases. Keywords : Frechet Distribution, Stress-Strength Cascade Model, Reliability for Cascade Model.
Real-time myoelectric control of a multi-fingered hand prosthesis using principal components analysis (2012)

This work demonstrates that the proposed two-DoFs myoelectric controller based on PCA allows to drive in real-time a prosthetic hand emulator into different prehensile patterns with excellent performance. These results open up promising possibilities for the development of intuitive, effective myoelectric hand controllers.
High Frequency of Latent and Clinical Human Papillomavirus Cervical Infections in Immunocompromised Human Immunodeficiency Virus-Infected Women (1992)

In 32 human immunodeficiency virus (HIV)-infected women, routine gynecologic examination was performed with colposcopy and Papanicolaou smear; cervical swabs were collected for human papillomavirus (HPV) DNA screening and typing; and immune status was assessed by CD4 T-cell count. Dot blot analysis was specifically chosen for HPV DNA screening to detect only relatively substantial HPV DNA infections. Polymerase chain reaction analysis was used for precise DNA typing of dot blot-positive samples. The HPV data were assessed for immune status; a subject with a CD4 T-cell count below 200/μL was considered functionally immunosuppressed. The frequency of dot blot positivity was fivefold higher among immunocompromised (nine of ten) than relatively immunocompetent (four of 22) HIV-infected women. Moreover, four immunosuppressed women, compared with no immunocompetent subjects, had evidence of HPV DNA without signs of HPV-associated lesions by cytology or histology (ie, latent HPV infection). Furthermore, four of nine of the immunocompromised, compared with four of 21 immunocompetent, subjects had cervical intraepithelial neoplasia. These frequencies are high compared with those reported in the general population. Finally, HPV 18 was detected in five of the ten women with CD4 T-cell counts below 200/μL and in only one of the 22 with CD4 T-cell counts above that level. These results suggest that the normal immune system suppresses latent and clinical HPV cervical infections and that the efficiency of suppression may be HPV type-specific. Furthermore, impaired immune status, as reflected by CD4 T-cell count, is an important factor increasing the severity of HPV-induced cervical infections in this population.(Obstet Gynecol 1992;79:321-7)
Robust Depth Estimation by Fusion of Stereo and Focus Series Acquired with a Camera Array (2006)

In order to obtain depth information from intensity sensors without auxiliary means, an image series is needed, gathered by varying at least the geometrical or focus position of the camera. Each of the fusion methods imposes certain constraints on the observed scene. With the aim of alleviating these restrictis, this contribution presents an algorithm to fuse combined stereo and focus series using energy functionals. A camera array is employed to record the series of images simultaneously.
Catalytically Stable and Active CeO<sub>2</sub> Mesoporous Spheres (2010)

A facile one-step strategy has been developed for preparing monodisperse CeO(2) mesoporous spheres with high surface areas, uniform size distributions, and well-defined pore topologies. These mesoporous spheres have been demonstrated to be catalytically stable and active for CO oxidation.
The Wheelbarrow: Its Use in Psychoanalysis (1994)

The article uses the concept of the wheelbarrow in order to illustrate its use in psychoanalysis.
The situation of common wheat rusts in the Southern Cone of America and perspectives for control (2007)

Approximately 9 million ha of wheat (Triticum aestivum and T. durum) is sown in the Southern Cone of America (Argentina, Brazil, Chile, Paraguay, and Uruguay). Two rust epidemiological zones separated by the Andean mountain range have been described in the region. Presently, leaf rust (caused by Puccinia triticina) is the most important rust disease of wheat. The utilisation of susceptible or moderately susceptible cultivars in a high proportion of the wheat area allows the pathogen to oversummer across large areas, resulting in early onset of the epidemics. Severe epidemics cause important economic losses if chemical control is not used. The pathogen population is extremely dynamic, leading to transitory resistance in commercial cultivars. Lr34 is commonly present in the regional germplasm, but there is limited knowledge about the presence of other genes conferring resistance in cultivars. Genes Lr28, Lr36, Lr38, Lr41, and Lr43 provide effective resistance in the region. The best strategy for the stabilisation of the pathogen population and resistance is considered to be the use of adult plant resistance conferred by minor additive genes including Lr34 and Lr46. Sources of this type of resistance from CIMMYT and the region have been made available to breeding programs in the Southern Cone. Stripe rust (P. striiformis f. sp. tritici) is endemic in Chile where chemical control is required to prevent severe losses in stripe rust susceptible cultivars. Although new virulent races emerge frequently, resistance genes Yr5, Yr8, Yr10, Yr15, and YrSp are currently effective in Chile. Some important stripe rust epidemics have occurred in Argentina, Brazil, and Uruguay. Avoiding the use of highly susceptible cultivars appears to be an effective strategy to prevent stripe rust epidemic development in this area. There have been no serious stem rust (P. graminis f. sp. tritici) epidemics for over 2 decades; the disease was controlled by resistant cultivars. The most important genes conferring resistance in Southern Cone germplasm at the present time are probably Sr24 and Sr31. Other effective genes are Sr22, Sr25, Sr26, Sr32, Sr33, Sr35, Sr39, and Sr40. Several stem rust susceptible wheat cultivars have recently been released. The increased cultivation of susceptible cultivars may lead to higher stem rust incidence, increasing the probability of appearance of new virulent races. Since the 1BL.1RS translocation possessing Sr31 is present in a high proportion of the regional germplasm, the possible introduction of stem rust with Sr31 virulence from Africa is of great concern.
Completely Monodisperse, Highly Repetitive Proteins for Bioconjugate Capillary Electrophoresis: Development and Characterization (2011)

Protein-based polymers are increasingly being used in biomaterial applications because of their ease of customization and potential monodispersity. These advantages make protein polymers excellent candidates for bioanalytical applications. Here we describe improved methods for producing drag-tags for free-solution conjugate electrophoresis (FSCE). FSCE utilizes a pure, monodisperse recombinant protein, tethered end-on to a ssDNA molecule, to enable DNA size separation in aqueous buffer. FSCE also provides a highly sensitive method to evaluate the polydispersity of a protein drag-tag and thus its suitability for bioanalytical uses. This method is able to detect slight differences in drag-tag charge or mass. We have devised an improved cloning, expression, and purification strategy that enables us to generate, for the first time, a truly monodisperse 20 kDa protein polymer and a nearly monodisperse 38 kDa protein. These newly produced proteins can be used as drag-tags to enable longer read DNA sequencing by free-solution microchannel electrophoresis.
Improved Synthesis of Symmetrical N,N’-Alkylidene Bisamides (1996)

N,N'-Alkylidene bisamides were synthesized in good yield from aliphatic or aromatic aldehydes and amides in the presence of catalytic amounts of trifluoromethanesulfonic acid (triflic acid).
Major Histocompatibility Complex Class II-associated Invariant Chain Gene Expression Is Up-regulated by Cooperative Interactions of Sp1 and NF-Y (1995)

Expression of the major histocompatibility complex (MHC) class II-associated invariant chain (Ii) is required for efficient and complete presentation of antigens by MHC class II molecules and a normal immune response. The Ii gene is generally co-regulated with the MHC class II molecules at the level of transcription and a shared SXY promoter element has been described. This report defines the proximal promoter region of Ii which may regulate Ii transcription distinct from MHC class II. In vivo genomic footprinting identified an occupied, imperfect CCAAT box and an adjacent GC box in the proximal region. These sites are bound in Ii-ositive cell lines and upon interferon-gamma induction of Ii transcription. In contrast, both sites are unoccupied in Ii-egative cell lines and in inducible cell lines prior to interferon-gamma treatment. Together these two sites synergize to stimulate transcription. Independently, the transcription factor NF-Y binds poorly to the imperfect CCAAT box with a rapid off rate, while Sp1 binds to the GC box. Stabilization of NF-Y binding occurs upon Sp1 binding to DNA. In addition, the half-life of Sp1 binding also increased in the presence of NF-Y binding. These findings suggest a mechanism for the complete functional synergy of the GC and CCAAT elements observed in Ii transcription. Furthermore, this report defines a CCAAT box of imperfect sequence which binds NF-Y and activates transcription only when stabilized by an adjacent factor, Sp1.
Luminal Foam Cell Accumulation Is Associated With Smooth Muscle Cell Death in the Intimal Thickening of Human Saphenous Vein Grafts (1996)

The close spatial relation among foam cell accumulation, pronounced intimal SMC loss, and cell death suggests the presence of a foam cell-derived factor that can induce cell death in the SMC population of the intimal thickening. The depletion of the intimal SMC population could promote plaque rupture and thrombotic complications in the grafts.
Efficient Multidimensional Aggregation for Large Scale Monitoring (2012)

International audience
Modeling spectral variability for the classification of depressed speech (2013)

Quantifying how the spectral content of speech relates to changes in mental state may be crucial in building an objective speech-based depression classification system with clinical utility. This paper investigates the hypothesis that important depression based information can be captured within the covariance structure of a Gaussian Mixture Model (GMM) of recorded speech. Significant negative correlations found between a speaker’s average weighted variance a GMMbased indicator of speaker variability and their level of depression support this hypothesis. Further evidence is provided by the comparison of classification accuracies from seven different GMM-UBM systems, each formed by varying different parameter combinations during MAP adaption. This analysis shows that variance-only adaptation either outperforms or matches the de facto standard mean-only adaptation when classifying both the presence and severity of depression. This result is perhaps the first of its kind seen in GMM-UBM speech classification.
Scaffold-assisted cartilage tissue engineering using infant chondrocytes from human hip cartilage (2013)

These results suggest that culture of expanded and/or de-differentiated infant hip cartilage cells in PGA-fibrin scaffolds initiates chondrocyte re-differentiation. The heterogenous donor tissue containing immature chondrocytes bears the risk of cartilage repair failure in vivo, which may be possibly overcome by the addition of PRP.