gebhart/patrepeval huggingface dataset:
Multiple-sensor integration for rapid and high-precision coordinate metrology (1999)

This paper presents an integrated framework that supports multiple sensor integration for rapid and high precision coordinate metrology. Rapid acquisition of high precision coordinate data from parts having complex geometry has many applications. Typical examples include part localization and automatic calibration in inspection and agile machining, coordinate metrology in dimensional control, and reverse engineering in rapid product design and realization. In this paper, information aggregation technology that facilitates rapid acquisition of high precision coordinate data is developed and demonstrated using a multi sensor integrated coordinate measuring system. The multi-sensor coordinate measuring system consists of a high precision coordinate measuring machine (CMM), a motorized probe, and an active vision system. The active vision system along with intelligent feature recognition algorithms provides the global information of the unknown object, including location and orientation, surface geometry, and feature topology. The obtained information is subsequently used to plan the most informative view for the next measurement, to guide the mechanical probe for high speed coordinate data acquisition, and to strategically control the coordinate measuring machine for high precision/rapid sampling of critical surface areas. By integrating the developed technology with the state of the art equipment, a highly automated, high speed, high precision, 3D coordinate acquisition system is developed. It has potential applications in a whole spectrum of manufacturing problems with a major impact on metrology, inspection, and reverse engineering.
The X-Stop Files (1997)

Software filters present one way to examine the contents of the Internet. Libraries providing Internet access have been turning to these programs as a way to handle concerns over the contents of some sites and servers. Some programs, however, filter at a broad level, causing loss of information and access denial to certain digital locations.
Fabrication and test of a submicroliter-level thermopneumatic micropump for transdermal drug delivery (2005)

This paper presents the fabrication and test of a thermopneumatic micropump without membrane for transdermal drug delivery systems (DDS). A micropump consists of two air chambers, a microchannel and a stop valve The air chambers have ohmic heaters on the Pyrex glass substrate. They can be achieved by the precise control of the drug delivery amount. The micropump is fabricated by the spin-coating process, the lithograph process, the molding process and etc. The total size of micropump and the resistance of the micro heater are 13/spl times/9 mm/sup 2/ and 690 /spl Omega/, respectively. The meniscus motion in the microchannel is observed with a high speed camera and discharge volume of the micropump is calculated through the frame analysis of the recorded video data. Each discharge volumes are 0.1 /spl mu/l/for 3 sec at 15 V and 0.1 /spl mu/l/for 1.8 sec at 20 V.
Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression (2018)

Group II metabotropic glutamate receptors (mGluR2 and mGluR3) are implicated in a number of psychiatric disorders. They also control sleep-wake architecture and may offer novel therapeutic targets. However, the roles of the mGluR2 versus mGluR3 subtypes are not well understood. Here, we have taken advantage of the recently described mutant strain of Han Wistar rats, which do not express mGluR2 receptors, to investigate behavioural, sleep and EEG responses to mGluR2/3 ligands. The mGluR2/3 agonist, LY354740 (10 mg/kg), reversed amphetamine- and phencyclidine-induced locomotion and rearing behaviours in control Wistar but not in mGluR2 lacking Han Wistar rats. In control Wistar but not in Han Wistar rats the mGluR2/3 agonist LY379268 (3 & 10 mg/kg) induced REM sleep suppression with dose-dependent effects on wake and NREM sleep. By contrast, the mGluR2/3 antagonist LY3020371 (3 & 10 mg/kg) had wake-promoting effects in both rat strains, albeit smaller in the mGluR2-lacking Han Wistar rats, indicating both mGluR2 and mGluR3-mediated effects on wakefulness. LY3020371 enhanced wake cortical oscillations in the theta (4-9 Hz) and gamma (30-80 Hz) range in both Wistar and Han Wistar rat strains, whereas LY379268 reduced theta and gamma oscillations in control Wistar rats, with minimal effects in Han Wistar rats. Together these studies illustrate the significant contribution of mGluR2 to the antipsychotic-like, sleep and EEG effects of drugs acting on group II mGluRs. However, we also provide evidence of a role for mGluR3 activity in the control of sleep and wake cortical theta and gamma oscillations.
Tashkent+ (2007)

We present a memory-aware load balancing (MALB) technique to dispatch transactions to replicas in a replicated database. Our MALB algorithm exploits knowledge of the working sets of transactions to assign them to replicas in such a way that they execute in main memory, thereby reducing disk I/O. In support of MALB, we introduce a method to estimate the size and the contents of transaction working sets. We also present an optimization called update filtering that reduces the overhead of update propagation between replicas.
Potentiation of plasminogen activation by an anti-urokinase monoclonal antibody due to ternary complex formation. A mechanistic model for receptor-mediated plasminogen activation. (1993)

We have observed that a murine IgG1 monoclonal antibody directed against human urokinase-type plasminogen activator (uPA) greatly potentiates pro-uPA-mediated plasminogen activation. This effect was dependent on the interaction between the immunoglobulin and the kringle domain of pro-uPA and could be competed efficiently by kringle-containing proteolytic fragments of uPA. In addition, the potentiation could also be competed by the lysine analog 6-aminohexanoic acid, an antagonist of plasminogen binding. This unexpected plasminogen binding dependence was found to be due to a carboxyl-terminal lysine residue on the immunoglobulin gamma chain, which by analogy with other proteins represents a potential binding site for plasminogen. Removal of this residue with carboxypeptidase B resulted in a complete abolition of the potentiation. It appears therefore that the potentiatory effect involves a novel mechanism with the antibody acting to provide a specific template for the assembly of a ternary complex involving pro-uPA/uPA and plasminogen, enabling them to interact in a catalytically favorable manner. This interpretation was confirmed by studying the kinetics of plasminogen activation by the complex between active, two-chain uPA and the antibody, which resulted in an overall 50-fold increase in reaction efficiency (kcat/Km), primarily due to a reduction in Km from 20 to 0.1 microM. Pro-uPA activation by plasmin was also accelerated, although to a lesser extent. The potentiation due to complex formation also provides a mechanism for the initiation of this system, dependent only on the low intrinsic proteolytic activity of the zymogen forms. The effects observed here, mediated by ternary complex formation, simulate the effects we have previously observed on assembly of the uPA receptor-mediated cellular plasminogen activation system and may therefore represent a mechanistic model for both its activity and initiation.
Changes in solvation during DNA binding and cleavage are critical to altered specificity of the <i>Eco</i> RI endonuclease (1998)

Restriction endonucleases such as EcoRI bind and cleave DNA with great specificity and represent a paradigm for protein-DNA interactions and molecular recognition. Using osmotic pressure to induce water release, we demonstrate the participation of bound waters in the sequence discrimination of substrate DNA by EcoRI. Changes in solvation can play a critical role in directing sequence-specific DNA binding by EcoRI and are also crucial in assisting site discrimination during catalysis. By measuring the volume change for complex formation, we show that at the cognate sequence (GAATTC) EcoRI binding releases about 70 fewer water molecules than binding at an alternate DNA sequence (TAATTC), which differs by a single base pair. EcoRI complexation with nonspecific DNA releases substantially less water than either of these specific complexes. In cognate substrates (GAATTC) kcat decreases as osmotic pressure is increased, indicating the binding of about 30 water molecules accompanies the cleavage reaction. For the alternate substrate (TAATTC), release of about 40 water molecules accompanies the reaction, indicated by a dramatic acceleration of the rate when osmotic pressure is raised. These large differences in solvation effects demonstrate that water molecules can be key players in the molecular recognition process during both association and catalytic phases of the EcoRI reaction, acting to change the specificity of the enzyme. For both the protein-DNA complex and the transition state, there may be substantial conformational differences between cognate and alternate sites, accompanied by significant alterations in hydration and solvent accessibility.
Authenticated Index Structures for Aggregation Queries (2010)

Query authentication is an essential component in Outsourced DataBase (ODB) systems. This article introduces efficient index structures for authenticating aggregation queries over large datasets. First, we design an index that features good performance characteristics for static environments. Then, we propose more involved structures for the dynamic case. Our structures feature excellent performance for authenticating queries with multiple aggregate attributes and multiple selection predicates. Furthermore, our techniques cover a large number of aggregate types, including distributive aggregates (such as SUM, COUNT, MIN, and MAX), algebraic aggregates (such as the AVG), and holistic aggregates (such as MEDIAN and QUANTILE). We have also addressed the issue of authenticating aggregation queries efficiently when the database is encrypted to protect data confidentiality. Finally, we implemented a working prototype of the proposed techniques and experimentally validated the effectiveness and efficiency of our methods.
Suction Detection for the MicroMed DeBakey Left Ventricular Assist Device (2005)

The MicroMed DeBakey Ventricular Assist Device (MicroMed Technology, Inc., Houston, TX) is a continuous axial flow pump designed for long-term circulatory support. The system received CE approval in 2001 as a bridge to transplantation and in 2004 as an alternative to transplantation. Low volume in the left ventricle or immoderate pump speed may cause ventricular collapse due to excessive suction. Suction causes decreased flow and may result in patient discomfort. Therefore, detection of this critical condition and immediate adaptive control of the device is desired. The purpose of this study is to evaluate and validate system parameters suitable for the reliable detection of suction. In vitro studies have been performed with a mock loop allowing pulsatile and nonpulsatile flow. Evidence of suction is clearly shown by the flow waveform reported by the implanted flow probe of the system. For redundancy to the implanted flow probe, it would be desirable to use the electronic motor signals of the pump for suction detection. The continuously accessible signals are motor current consumption and rotor/impeller speed. The influence of suction on these parameters has been investigated over a wide range of hydrodynamic conditions, and the significance of the respective signals individually or in combination has been explored. The reference signal for this analysis was the flow waveform of the ultrasonic probe. To achieve high reliability under both pulsatile and nonpulsatile conditions, it was determined that motor speed and current should be used concurrently for suction detection. Using the amplified differentiated current and speed signals, a suction-detection algorithm has been optimized, taking into account two different working points, defined by the value of the current input. The safety of this algorithm has been proven in vitro under pulsatile and nonpulsatile conditions over the full spectrum of possible speed and differential pressure variations. The algorithm described herein may be best utilized to provide redundancy to the existing flow based algorithm.
Finite state model predictive control for 3&#x00D7;3 matrix converter based on switching state elimination (2014)

Model Predictive Control (MPC) with a finite control set has been successfully applied to several power converter topologies and research on predictive control techniques has increased over the last few years. This paper presents a novel model predictive control scheme for the three-phase Direct Matrix Converter based on switching state elimination. The conventional MPC solves a multi-objective optimization problem by minimizing a multi-objective cost function over a one-step horizon. The control performance is strongly affected by the weighting factors used in the cost function, and this is problematic, since no formal method to determine their values has been provided in the literature. A time consuming simulation-based tuning technique is typically used. The proposed method solves this difficulty by eliminating the weighting factors and using a switching state elimination method based on error constraints that have a clear physical interpretation.
Enhanced Patterns of Oriented Edge Magnitudes for Face Recognition and Image Matching (2011)

A good feature descriptor is desired to be discriminative, robust, and computationally inexpensive in both terms of time and storage requirement. In the domain of face recognition, these properties allow the system to quickly deliver high recognition results to the end user. Motivated by the recent feature descriptor called Patterns of Oriented Edge Magnitudes (POEM), which balances the three concerns, this paper aims at enhancing its performance with respect to all these criteria. To this end, we first optimize the parameters of POEM and then apply the whitened principal-component-analysis dimensionality reduction technique to get a more compact, robust, and discriminative descriptor. For face recognition, the efficiency of our algorithm is proved by strong results obtained on both constrained (Face Recognition Technology, FERET) and unconstrained (Labeled Faces in the Wild, LFW) data sets in addition with the low complexity. Impressively, our algorithm is about 30 times faster than those based on Gabor filters. Furthermore, by proposing an additional technique that makes our descriptor robust to rotation, we validate its efficiency for the task of image matching.
METABOLIC STUDIES OF URIDINE IN RATS WITH DOCA‐SALT HYPERTENSION AND ON HIGH SODIUM DIET (1993)

1. The steady-state metabolic clearance and calculated secretion rate of the pyrimidine nucleoside uridine were studied by equilibrium infusion in normal rats, rats on a high sodium diet, rats made hypertensive by subcutaneous injection of deoxycorticosterone acetate (DOCA), unilateral nephrectomy and high sodium drinking fluid, and two control groups of rats for the hypertensive group. 2. Basal plasma uridine concentration in DOCA-salt hypertension rats was found to be significantly reduced to 3.99 +/- 0.31 mumol/L (mean +/- s.e.m.) compared with control rats (11.98 +/- 1.64 mumol/L). Metabolic clearance (MCR) in DOCA-salt hypertensive rats was significantly raised (200.54 +/- 10.77 mL/kg per min) compared with control rats (65.17 +/- 1.99 mL/kg per min). No difference was found in plasma uridine concentration and MCR among the other two control groups and high sodium diet rats. Calculated secretion rate was unchanged in all animals. No significant differences were found between different groups of rats in blood pressure responses to uridine. 3. The raised metabolic clearance and reduced plasma uridine concentration in DOCA-salt hypertension may be consistent with increased intracellular transport and phosphorylation of uridine to the physiologically active compound uridine monophosphate (UMP) which would lead to arteriolar constriction, hypertension and natriuresis. The results contrast with those in humans with extracellular fluid (ECF) expansion from endstage renal failure and rats with one-kidney, one-clip (1K1C) hypertension but are not due to the pharmacological effects of deoxycorticosterone. The difference may be due to the haemodynamic consequences of reduced renal perfusion pressure or reduced renal mass compared with DOCA-salt model.
Boysenberry ingestion supports fibrolytic macrophages with the capacity to ameliorate chronic lung remodeling (2016)

Lung fibrosis negatively impacts on lung function in chronic asthma and is linked to the development of profibrotic macrophage phenotypes. Epidemiological studies have found that lung function benefits from increased consumption of fruit high in polyphenols. We investigated the effect of boysenberry consumption, in both therapeutic and prophylactic treatment strategies in a mouse model of chronic antigen-induced airway inflammation. Boysenberry consumption reduced collagen deposition and ameliorated tissue remodeling alongside an increase in the presence of CD68+CD206+arginase+ alternatively activated macrophages in the lung tissue. The decrease in tissue remodeling was associated with increased expression of profibrolytic matrix metalloproteinase-9 protein in total lung tissue. We identified alternatively activated macrophages in the mice that consumed boysenberry as a source of the matrix metalloproteinase-9. Oral boysenberry treatment may moderate chronic tissue remodeling by supporting the development of profibrolytic alternatively activated macrophages expressing matrix metalloproteinase-9. Regular boysenberry consumption therefore has the potential to moderate chronic lung remodeling and fibrosis in asthma and other chronic pulmonary diseases.
Biogenetically diverse, bioactive constituents of a sponge, order Verongida: bromotyramines and sesquiterpene-shikimate derived metabolites (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiogenetically diverse, bioactive constituents of a sponge, order Verongida: bromotyramines and sesquiterpene-shikimate derived metabolitesMark T. Hamann, Paul J. Scheuer, and Michelle Kelly-BorgesCite this: J. Org. Chem. 1993, 58, 24, 6565–6569Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/jo00076a012https://doi.org/10.1021/jo00076a012research-articleACS PublicationsRequest reuse permissionsArticle Views587Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Solid-State-Drive qualification and reliability strategy (2015)

As NAND flash memories have scaled the margin between NAND capability and system requirements have been significantly reduced. Understanding Solid-State-Drive (SSD) reliability and qualification requirements has become more critical since these impact the NAND flash design tradeoffs. Unrealistically high expectations result in excessive margin that could have been used in other areas, while too low of a requirement puts the system at risk for excessive field failure. The reliability and qualification requirements for SSDs will be reviewed and discussed in order to give an overview of what constitutes an effective qualification/reliability strategy for SSDs.
WebRTC IP Address Handling Recommendations (2015)

This document provides best practices for how IP addresses should be
handled by WebRTC applications.
The Production of Spiral Bevel Gears by Computer Aided Manufacturing Techniques (1977)

Very little research has been carried out in the area of applying computer aided manufacturing techniques to the manufacture of gears. The main problems in the production of gears of this type is to adequately describe the space curves necessary to describe the cutting action. In addition to apply this knowledge to obtain the desired relative motions of the machine tool axes and cutter rotation. This paper describes a computerised approach to the calculation of the cutter paths to generate spiral bevel gears and its implementation into a C.N.C. system. In addition the program calculates the necessary dimensions for setting the tool and blank. With the information supplied by the output of the program, it is possible to set up a numerically controlled machine tool in approximately ten minutes, for cutting of spiral bevel gears. This research results in the ability to cut gears on numerically controlled machine tools in a batch production mode.
Quinoxalin-2(1<i>H</i>)-One Derivatives As Inhibitors Against Hepatitis C Virus (2011)

Hepatitis C virus (HCV) infection is a serious problem worldwide, but no effective drugs are currently available. Through screening of our privileged structure library, quinoxalin-2(1H)-one derivative N-(7-(cyclohexyl(methyl)amino)-3-oxo-3,4-dihydroquinoxalin-6-ylcarbamothioyl)benzamide (compound 1) was identified as potent HCV inhibitor in vitro. Subsequently, a structure-activity relationship analysis was carried out that showed N-(7-(cyclohexyl(methyl)amino)-3-oxo-3,4-dihydroquinoxalin-6-ylcarbamothioyl)furan-2-carboxamide (compound 11, EC(50)=1.8 μM, SI=9.6), 6-(cyclohexyl(methyl)amino)-7-(4-phenylthiazol-2-ylamino)quinoxalin-2(1H)-one (compound 33, EC(50)=1.67 μM, SI=37.4), 2-(cyclohexyl(methyl)amino)-3-(4-phenylthiazol-2-ylamino)-7,8,9,10-tetrahydro-5H-pyrido[1,2-a]quinoxalin-6(6aH)-one (compound 60, EC(50)=1.19 μM, SI=9.27), 8-(cyclohexyl(methyl)amino)-7-(4-phenylthiazol-2-ylamino)pyrrolo[1,2-a]quinoxalin-4(5H)-one (compound 65, EC(50)=1.82 μM, SI=9.9), and 6-(diethylamino)-7-(4-phenylthiazol-2-ylamino)quinoxalin-2(1H)-one (compound 78, EC(50)=1.27 μM, SI=17.9) acted against HCV. The data from the structure-activity relationship study suggests that quinoxalin-2(1H)-one derivatives exhibited potent activity against HCV.