gebhart/patrepeval huggingface dataset:
Preliminary study of a novel method for conveying corrected image volumes in surgical navigation (2012)

These results suggest that our new technique can be used in place of the computationally expensive task of deforming the image volume, without affecting the time or accuracy of the surgical task. Most notably, our work addresses the problem of incorporating deformation correction into the guidance display and offers a first step toward understanding its effect on surgical performance.
Influence of Pseudowollastonite on the Performance of Low Calcium Amorphous Hydraulic Binders (2019)

A systematic investigation of the influence of pseudowollastonite on the performance of a new family of low calcium hydraulic binders is described. Samples of the new low calcium binder were produced by an innovative process consisting of heating and homogenizing the mix of raw materials (limestone, sand, and fuel cracking catalyst) at a constant temperature followed by the rapid cooling of the mixture itself. Different maximum temperatures, close to the melting temperature of the mix, were tested, and materials with CaO/SiO<sub>2</sub> (C/S) ratios of 0.9, 1.1, and 1.25 were produced into the form of the amorphous phase with small percentages of pseudowollastonite. Compressive strength results were determined at 7, 28, and 90 days of hydration, and the hydrated phases were analyzed using isothermal calorimetry, X-ray diffraction (XRD) analysis, thermogravimetry analysis (TGA), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). The present work is focused on the influence of the percentage of the pseudowollastonite phase on the binder compressive strength performance.
Response of mice to rotaviruses of bovine or primate origin assessed by radioimmunoassay, radioimmunoprecipitation, and plaque reduction neutralization (1983)

Sera from (i) gnotobiotic BALB/c, CD-1, and CFW mice and (ii) conventional BALB/c mice were evaluated by radioimmunoassay, radioimmunoprecipitation, and plaque reduction neutralization, using the Wa, SA-11, and WC-3 (bovine) strains of rotavirus as the detecting antigens. The gnotobiotic mice had no antirotavirus antibody detectable by radioimmunoprecipitation and no neutralizing antibody at a dilution of 1:50 by plaque reduction neutralization. All sera from the conventional mice had rotavirus-specific antibodies detected by radioimmunoassay and by radioimmunoprecipitation at serum dilutions of 1:50 and 1:10,000, respectively. The antibodies were directed against viral proteins p116, p94, p88, and p84 of all three viruses, but had no neutralizing activity against heterologous rotaviruses at a dilution of 1:50. Conventional seropositive mice were parenterally immunized with the Wa, SA-11, or WC-3 strain of rotavirus. An approximate 100-fold increase in rotavirus-specific antibodies was detected by radioimmunoassay, and greater than 20-fold selective neutralization of the immunizing strain of virus was observed. Sera from the mice immunized with Wa virus had antibodies directed against inner and outer capsid proteins of all three rotaviruses. The mouse can be a useful model for studying the immune response to heterologous rotavirus infection; preexisting antibodies presumably directed towards murine rotavirus do not prevent the development of a type-specific immune response to a nonmurine rotavirus.
A QoS architecture for future wireless IP networks (2000)

This paper presents a QoS architecture framework with preliminary protocol specifications for next generation wireless IP networks. The architecture is based on differentiated services, in that traffic are aggregated and forwarded in backbone network based on per hop behaviors; however, it is also offers a dynamic per session QoS negotiation which is needed to efficiently support roaming users. The proposed architecture has at least one global server and many dumb local nodes in each administrative domain. The server is referred to as the QoS Global Server (or QGS), and local nodes are referred to as QoS local nodes (or QLN). QLNs are ingress nodes of the DS (Differentiated Service) domain which police traffic for agreement with the Service Level Specification (SLS). The mobile nodes do not do any negotiation with the dumb QLNs; rather they negotiate with the QGS. The QGS is basically a dynamic version of a differentiated services bandwidth broker, which stores global information of the whole domain. The QGS informs the QLNs what to do when traffic comes in. By retaining the global information in central server and separating control and transport, the architecture is flexible, easy to add new services, and efficient for mobile environment.
Development of Ultra-Low NOx Combustor Technology for Next Generation Supersonic Transport Engines in ESPR Project (2003)

Ultra-low NOx combustor technology is being developed for aero engines of the next generation supersonic transport in the ESPR program. The emissions of a single sector staged combustor with a main burner of lean premixed and prevaporized type and a pilot were evaluated at major operating conditions including cruise. Neither flashback nor autoignition occurred at either take-off or cruise conditions even when the mixture velocity was halved. The NOx emissions are encouraging in that an EINOx of 3.8 g/kg-fuel has been achieved at conditions simulating a supersonic passenger aircraft engine at Mach 2.2 cruise.
Non-invasive measurements of wool and meat properties (2005)

Recently, strong progress has been made in the development of non-invasive measurement equipment and techniques for the in-line determination of raw wool and boneless meat qualities in industrial applications. Wool base is a measure of the matter that comprises the 'real' wool, apart from grease, sheep gland excretions (called 'suint'), water and vegetable matter. In meat we investigate the chemical lean as a percentage, where the remaining percentage is attributed to fat. These qualities are important parameters which determine their commercial return value. The instrumentation is based on dual energy X-ray (DEXA) scanning and detection, where an image of the scanned object is created and subsequently analysed without interrupting the process flow within the factory. In this technique, every pixel of the image provides data for a high and low energy X-ray beam, where both X-ray energies result from single X-ray energy spectrum generation. In wool, we developed a method to determine the wool base in raw wool by evaluating and comparing both energies for every pixel and finding mean properties for the entire fleece. The method is very promising, and we expect industrial applications to be employed in the future. We also developed a method to determine the chemical lean in boneless meat that is packed in standard size meat boxes. This method is successfully installed in industry, scanning nearly continuously several thousand meat boxes each day. Single energy analysis can be successfully employed to scan wool or meat for contamination, which is also briefly discussed.
Spatiotemporal phase-shifting method for accurate phase analysis of fringe pattern (2019)

Abstract High accurate phase analysis of waveforms as fringe patterns is essential for a wide range of scientific and engineering disciplines. However, precise phase analysis under extremely low signal-to-noise conditions is a challenging task for conventional phase-shifting methods. Here, a novel accurate phase recovering technique, called the spatiotemporal phase-shifting method (ST-PSM), is developed to measure the phase information robustly by utilizing two-dimensional intensity data in spatial- and temporal-domains simultaneously. Our simulation results indicated that ST-PSM had strong tolerance to random noise, and a self-neutralizing function to eliminate the periodical phase error due to the nonlinearity of detector, intensity saturation, vibration or phase-shifting error. The effectiveness was demonstrated experimentally from a non-contact shape measurement in fringe projection profilometry under extreme underexposure and overexposure recording conditions. Furthermore, by incorporating modern GPU parallel computing technology, a 4-step phase-shifted fringe pattern with 8 K image size can be calculated within one second. Due to its robustness and high accuracy with a fast calculation, therefore, we believe this technique has a significant impact on a variety of research and scientific fields.
Optical Scanning Holography: Origin, Modern Capabilities and Beyond (2011)

In 1979, Professor Adrian Korpel and I had an idea on how to implement bipolar point spread functions in incoherent image processing via acousto-optics. We successfully implemented the idea and at the same time, we recognized that the idea could be generalized to include holographic recording using optical scanning – a novel departure from conventional digital holography. In this paper, I review this idea, discuss its modern capabilities and finally mention some of the important applications that are worth pursuing in the future.
sup 13 C NMR investigation of crosslinking in organic aerogels (1989)

Organic aerogels are a special type of low density foam produced from the supercritical drying of resorcinol-formaldehyde (RF) gels. These aerogels have continuous porosity, ultrafine cell/pore sizes (<1000 {angstrom}), and a microstructure composed of interconnected colloidal-like particles with diameters ranging from 30-175 {angstrom}. The particle size, surface area, density, and mechanical properties of the aerogels are largely determined by the catalysts concentration used in the sol-gel polymerization. In order to gain some insight into the crosslinks between RF particles, aerogels were labeled with C-13 formaldehyde at various times in the polymerization. CPMAS and IRCP techniques were used to correlate the relaxation behavior of the C-13 enriched aerogels with their different microstructures. 9 refs., 1 fig., 2 tabs.
Identification and selective inhibition of an isozyme of steroid 5 alpha-reductase in human scalp. (1992)

Steroid 5 alpha-reductase (EC 1.3.1.22) catalyzes the reduction of testosterone to dihydrotestosterone. The 5 alpha-reductase found in human scalp has been compared with the enzyme found in prostate. The scalp reductase has a broad pH optimum centered at pH 7.0. This is distinctly different from the pH optimum of 5.5 observed with the prostatic form of the enzyme. These enzymes also differ in the Km for testosterone, which is 25-fold higher for the scalp reductase. The most significant difference between the two enzymes is their affinity for inhibitors. Two 4-azasteroids and a 3-carboxyandrostadiene are potent inhibitors of the prostatic reductase but are weak inhibitors of the scalp reductase. In contrast, several N-4-methylazasteroids are good inhibitors of the scalp reductase. These findings support a proposal that different isozymes of 5 alpha-reductase may exist in scalp and prostate. The scalp reductase was also compared to 5 alpha-reductase 1, one of the two enzymes recently cloned from human prostate [Andersson, S. & Russell, D. W. (1990) Proc. Natl. Acad. Sci. USA 87, 3640-3644; and Andersson, S., Berman, D. M., Jenkins, E. P. & Russell, D. W. (1991) Nature (London) 354, 159-161]. The characteristics of the cloned reductase 1 are comparable to those of the scalp reductase.
Tandem modification of amphiphilic cellulose ethers for amorphous solid dispersion via olefin cross-metathesis and thiol-Michael addition (2017)

Tandem olefin cross-metathesis (CM) and thiol-Michael addition for modification of cellulose derivatives”.
A Novel RF-assisted-Strobe System for Unobtrusive Vibration Detection of Machine Parts (2020)

In this paper, we propose a novel non-contact vibration measurement system that is competent in estimating linear and/or rotational motions of machine parts. The technique combines microwave radar, standard camera, and optical strobe to capture vibrational or rotational motions in a relatively fast and affordable manner when compared to the current technologies. In particular, the proposed technique is capable of not only measuring common vibrational parameters (e.g. frequency, motor rpm, etc.) but also provides spatial information of the vibrational sources so that the origin of each vibrational point can be identified accurately. Furthermore, it can also capture the wobbling motion of the rotating shafts. Thus, the proposed method can find immense applications in preventive maintenance across various industries where heavy machinery needs to be monitored unobtrusively or there is a requirement for non-contact multi-point vibration measurement for any machine inspection applications.
A randomized phase 3 study of reslizumab efficacy in relation to blood eosinophil levels in patients with moderate to severe asthma (2014)

Introduction: Reslizumab (RES; anti-human interleukin-5) has been shown to reduce sputum eosinophils (EOS) and improve pulmonary function in asthma patients with elevated EOS. Objectives: To assess RES effect on asthma control measures in relation to baseline blood EOS in subjects with moderate to severe asthma. Methods: This was a double-blind, 16-wk study ( NCT01508936 ) in subjects aged 18-65 years with uncontrolled asthma (asthma control questionnaire [ACQ] score ≥1.5) treated with at least medium-dose ICS. Subjects were randomized 4:1 to intravenous RES 3.0 mg/kg (n=395) or placebo (PBO; n=97) once every 4 wks. Efficacy variables included change from baseline in FEV 1 (primary), ACQ, and rescue medication use. Results are presented for the overall population as well as stratified by baseline EOS count of ≥ or &lt;400/µL (definition of elevated EOS). Results: The prevalence of subjects with elevated EOS ≥400/µL was ∼20%. Following 16 wks of therapy, improvements in FEV 1 were greater for RES vs PBO for the overall population, subjects with EOS ≥400/µL, and subjects with EOS &lt;400/µL by 68 mL, 270 mL ( P =0.04), and 33 mL, respectively. ACQ improvements were greater for RES vs PBO for the overall population, subjects with EOS ≥400/µL, and subjects with EOS &lt;400/µL by -0.195 ( P =0.04), -0.490, and -0.122, respectively. Rescue medication use was less for RES vs PBO for subjects with EOS ≥400/µL (-0.708 inhalations/day). The most frequent AEs were asthma, URTI, sinusitis, bronchitis, nasopharyngitis, and nausea. Conclusion:Four monthly doses of RES were well tolerated, with the largest improvements in asthma control in subjects with baseline EOS ≥400/μL.
Grain Boundary and Triple Junction Chemistry of Silicon Carbide with Aluminum or Aluminum Nitride Additive (2006)

This chapter contains sections titled: Introduction Experimental Procedure Results and Discussion Summary Acknowledgments
X-ray multi-energy radiography with scintillator-photodiode detectors (2002)

For reconstruction of the spatial structure of many-component objects, it is proposed to use multi-radiography with detection of X-ray by combined detector arrays using detectors of ``scintillator-photodiode'' type. A theoretical model has been developed of multi-energy radiography for thickness measurements of multi-layered systems and systems with defects. Experimental studies of the sensitivity, output signal of various inspection systems based on scintillators $ZnSe(Te)$ and $CsI(Tl)$, and object image reconstruction (with organics and non-ogranics materials singled out) have been carried out.
Conductive carbon filled polymeric electrodes: Novel ion optical elements for time-of-flight mass spectrometers (2002)

A new technique employing conductive polymeric electrodes for the generation of linear electric fields is proposed and validated. A hollow cylinder comprised of DuPont's Vespel SP-22, a polymer loaded with conductive carbon particles, is used to enhance the performance of a hybrid reflectron compared to a conventional dual stage gridless reflectron composed of discrete metal ring electrodes. Both devices have comparable physical dimensions and nearly identical ion optical properties. Instrumental resolution measurements are used to validate this novel design.
Effective multiple oral administration of reverse genetics engineered infectious bursal disease virus in mice in the presence of neutralizing antibodies (2015)

Repeat oral administration of R903/78 was successful despite the presence of neutralizing antibodies. Single oral and intravenous administration indicated that IBDV does not replicate in mammalian liver alleviating some safety related concerns. These data supports the development of an orally delivered anti-hepatitis B virus/ anti-hepatitis C virus viral agent for human use.
RC delay metrics for performance optimization (2001)

For performance optimization tasks such as floorplanning, placement, buffer insertion, wire sizing, and global routing, the Elmore resistance-capacitance (RC) delay metric remains popular due to its simple closed form expression, fast computation speed, and fidelity with respect to simulation. More accurate delay computation methods are typically central processing unit intensive and/or difficult to implement. To bridge this gap between accuracy and efficiency/simplicity, we propose two new RC delay metrics called delay via two moments (D2M) and effective capacitance metric (ECM), which are virtually as simple and fast as the Elmore metric, but more accurate. D2M uses two moments of the impulse response in a simple formula that has high accuracy at the far end of RC lines. ECM captures resistive shielding effects by modeling the downstream capacitance by an "effective capacitance." In contrast, the Elmore metric models this as a lumped capacitance, thereby ignoring resistive shielding. Although not as accurate as D2M, ECM yields consistent performance and may be well-suited to optimization due to its Elmore-like recursive construction.
Interbus in safety critical applications (1999)

The introduction of bus systems in automation technology marked the beginning of a revolution for system operators. The new technology provided the user with new opportunities, which had previously been impossible using conventional technologies. Since its market launch in 1987, INTERBUS has gradually replaced parallel cabling. Alongside savings in extremely heavy wiring harnesses and intermediate terminal connections, customers now also benefit from, for example, diagnostic messages about the status of their systems. INTERBUS is a bus system which currently enables the user to network anything from basic sensors and actuators to complex control systems using a single bus cable, and it is now actively supported by several hundred manufacturers. It has always been possible to integrate new features into the system, so that even the earliest devices can still be used in systems today. For INTERBUS, compatibility is not just a word; it is a reality. INTERBS Safety, which will soon be available for use in safety-oriented applications, will also be compatible with existing INTERBUS networks, so that any investments already made will be secure for the future. It is even possible to integrate safety applications into operating INTERBUS systems retrospectively without major changes. This article highlights the basic implementation methods for INTERBUS Safety and provides an outlook for the future applications of INTERBUS Safety in safety technology.
Promotion of cross-presenting DC expansion in humanized mice and antigen-specific immunity in murine models of vaccination and cancer by Albumin-Flt3L (2020)

Abstract The ability to engender CD8+ T cell antitumor immunity is indispensable to the success of essentially all cancer treatment strategies. Because tumor (TM) cells do not efficiently process and present immunostimulatory epitopes to CD8+ T cells, cross-presenting dendritic cells (cDC1s) are often required to elicit potent cytotoxic T cell responses. Flt3L is a cytokine known for its ability to expand cDC1s, but is limited therapeutically due to short half-life and global distribution in vivo. To overcome this, we have generated a novel fusion protein of Albumin and Flt3L (Alb-Flt3L), as albumin has a long half-life and selective trafficking to the lymph node (LN) and TM. We demonstrate that Alb-Flt3L potently expands cDC1s in a Batf3-dependent fashion, exhibits long half-life, and accumulates in the LN and TM. Since the phenotype of human and mouse DCs differ, CD34+ stem cell humanized NSG mice were used to assess the immunomodulatory ability of Alb-Flt3L on human DCs. 20-color cytometry and single cell RNA-seq reveals that Alb-Flt3L potently expands human DCs while enhancing a pro-inflammatory transcriptional profile. To gauge the adjuvant ability of Alb-Flt3L, vaccination models using either OVA or HPV16 E7 proteins were performed and revealed that Alb-Flt3L potently enhances antigen-specific T and B cell responses. Finally, in multiple murine models of cancer, Alb-Flt3L + standard-of-care chemoradiation is able to promote tumor control and neoantigen-specific cytotoxic T cells by tetramer staining. The breadth and depth of the TCR repertoire was also investigated using TCRβ chain sequencing. In conclusion, Alb-Flt3L serves as a simple, yet potent strategy to induce DC expansion, antigen-specific immunity and tumor control.
Inhibition of bacteriophage replication in Streptococcus thermophilus by subunit poisoning of primase (2007)

Invariant and highly conserved amino acids within a primase consensus sequence were targeted by site-specific mutations within the putative primase of Streptococcus thermophilus phage kappa3. PCR products containing the desired mutation(s) within putative ATPase/helicase and/or oligomerization domains of the kappa3-encoded primase gene were cloned into a high-copy-number vector and expressed in S. thermophilus NCK1125. The majority of the plasmid constructs failed to alter phage sensitivity; however, four of the constructs conferred strong phage resistance upon the host. Expression of the K238(A/T) and RR340-341AA mutant proteins in trans suppressed the function of the native phage primase protein in a dominant negative fashion via a proposed subunit poisoning mechanism. These constructs completely inhibited phage genome synthesis and reduced the efficiencies of plaquing and centre of infection formation by more than 9 and 3.5 logs, respectively. Amber mutations introduced upstream of the transdominant RR340-341AA and K238(A/T) mutations restored phage genome replication and sensitivity of the host, indicating that translation was required to confer phage resistance. Introduction of an E437A mutation in a putative oligomerization domain located downstream of the transdominant K238T mutation also completely suppressed phage resistance. This study appears to represent the first use of transdominant proteins to inhibit phages that are disruptive to cultures used in industrial fermentations.
Effects of non‐euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice (2018)

This article is part of a themed section on 8<sup>th</sup> European Workshop on Cannabinoid Research. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.10/issuetoc.
Multi‐element selective radio frequency plasma detector for capillary gas chromatography (1988)

Abstract A radio frequency plasma detector for element specific detection in gas chromatography is described. The detector is comprised of a radio frequency (300 kHz) discharge between electrodes in helium, and utilizes a low‐resolution emission spectrometer to monitor selected spectral emission lines produced when the helium discharge decomposes and excites the atomic constituents in the chromatographic column effluent. The spectrometer is tuned to an atomic emission line in the near‐infrared portion of the spectrum, and the emission intensity from the discharge region of a selected line is used to monitor the concentration of the element producing that line. Acceptable detector sensitivity was achieved by the use of a high‐throughput optical system. Selectivity was achieved by a combination of correct line selection, plasma and carrier gas purification, and plasma gas doping.