gebhart/patrepeval huggingface dataset:
DECOMPOSING BUILDING SYSTEM DATA FOR MODEL VALIDATION AND ANALYSIS USING THE KOOPMAN OPERATOR (2010)

Large amounts of sensor information is often captured from either real world building sensors, or virtual building models, for many purposes including control design, fault or aging analysis, and model calibration. Because of the large dimension of this data on both spatial and temporal scales, it is often challenging to come to quick conclu-sions about what information of engineering importance is in the data. In this paper we present an approach to quickly assess spatial information in data based on the spectral content of a certain projection operator. We use operator theoretic methods to capture Koopman modes that represent the spatial content of oscillations in ther-mal quantities. By investigating these modes for different physically significant time-scales (e.g. diurnal, or control system time-scales) we can quickly capture how different parts of a building are responding to load changes at these frequencies (”breathing”). This information helps us to understand anomalies in different aspects of the data, as well as out of phase behavior between zones which may highlight areas of poor control system performance. We present actual and EnergyPlus data from a real building (170K square foot building with approximately 2000 data points) and illustrate how this approach to data analysis and model validation highlights aspects of the data which may otherwise have been overlooked.
Mitochondrial DNA sequence analysis of four Alzheimer's and Parkinson's disease patients (1996)

The mitochondrial DNA (mtDNA) sequence was determined on 3 patients with Alzheimer's disease (AD) exhibiting AD plus Parkinson's disease (PD) neuropathologic changes and one patient with PD. Patient mtDNA sequences were compared to the standard Cambridge sequence to identify base changes. In the first AD + PD patient, 2 of the 15 nucleotide substitutions may contribute to the neuropathology, a nucleotide pair (np) 4336 transition in the tRNAGln gene found 7.4 times more frequently in patients than in controls, and a unique np 721 transition in the 12S rRNA gene which was not found in 70 other patients or 905 controls. In the second AD + PD patient, 27 nucleotide substitutions were detected, including an np 3397 transition in the ND1 gene which converts a conserved methionine to a valine. In the third AD + PD patient, 2 polymorphic base substitutions frequently found at increased frequency in Leber's hereditary optic neuropathy patients were observed, an np 4216 transition in ND1 and an np 13708 transition in ND5 gene. For the PD patient, 2 novel variants were observed among 25 base substitutions, an np 1709 substitution in the 16S rRNA gene and an np 15851 missense mutation in the cytb gene. Further studies will be required to demonstrate a causal role for these base substitutions in neurodegenerative disease. © 1996 Wiley-Liss, Inc.
Cascaded quadratic soliton compression at 800 nm (2007)

We study soliton compression in quadratic nonlinear materials at 800 nm, where group-velocity mismatch dominates. We develop a nonlocal theory showing that efficient compression depends strongly on characteristic nonlocal time scales related to pulse dispersion.
Structure−Activity Relationship of (<i>N</i>)-Methanocarba Phosphonate Analogues of 5′-AMP as Cardioprotective Agents Acting Through a Cardiac P2X Receptor (2010)

P2X receptor activation protects in heart failure models. MRS2339 3, a 2-chloro-AMP derivative containing a (N)-methanocarba (bicyclo[3.1.0]hexane) system, activates this cardioprotective channel. Michaelis-Arbuzov and Wittig reactions provided phosphonate analogues of 3, expected to be stable in vivo due to the C-P bond. After chronic administration via a mini-osmotic pump (Alzet), some analogues significantly increased intact heart contractile function in calsequestrin-overexpressing mice (genetic model of heart failure) compared to vehicle-infused mice (all inactive at the vasodilatory P2Y(1) receptor). Two phosphonates, (1'S,2'R,3'S,4'R,5'S)-4'-(6-amino-2-chloropurin-9-yl)-2',3'-(dihydroxy)-1'-(phosphonomethylene)-bicyclo[3.1.0]hexane, 4 (MRS2775), and its homologue 9 (MRS2935), both 5'-saturated, containing a 2-Cl substitution, improved echocardiography-derived fractional shortening (20.25% and 19.26%, respectively, versus 13.78% in controls), while unsaturated 5'-extended phosphonates, all 2-H analogues, and a CH(3)-phosphonate were inactive. Thus, chronic administration of nucleotidase-resistant phosphonates conferred a beneficial effect, likely via cardiac P2X receptor activation. Thus, we have greatly expanded the range of carbocyclic nucleotide analogues that represent potential candidates for the treatment of heart failure.
Compact spectral pulse shaping using hybrid planar lightwave circuit and free-space optics with MEMS piston micromirrors and spectrogram feedback control (2004)

We combine a PLC and free-space optics for a compact Fourier-plane pulse shaper with low polarization dependencies. A micromirror array with piston motion provides phase modulation. The shaped electric field is extracted from a recorded spectrogram of the synthesized waveform.
Synthesis of Stishovite Nanocrystals from Periodic Mesoporous Silica (2009)

Faceted stishovite nanocrystals with sizes of 200-400 nm were synthesized at a pressure of 12 GPa and a temperature of 400 degrees C in a multianvil apparatus using mesoporous silica SBA-16 as the precursor.
RuCl<sub>2</sub>[(2,6-Me<sub>2</sub>C<sub>6</sub>H<sub>3</sub>)PPh<sub>2</sub>]<sub>2</sub>:  A New Precursor for Cyclometalated Ruthenium(II) Complexes (2004)

The five-coordinate complex RuCl{(2-CH2-6-MeC6H3)PPh2}(CO)(L*) (2; L* = (2,6-Me2C6H3)PPh2) was prepared in high yield by reaction of the 14-electron complex RuCl2(L*)2 (1) with formaldehyde in the presence of NEt3 via cyclometalation of an ortho methyl group and aldehyde decarbonylation. Alternatively, 2 can be obtained from RuCl3 hydrate, L*, H2CO, and amine in a one-pot reaction. Treatment of 2 with CO affords the cis-dicarbonyl derivative RuCl{(2-CH2-6-MeC6H3)PPh2}(CO)2(L*) (3), whereas reaction with phosphines leads to the five- and six-coordinate complexes RuCl{(2-CH2-6-MeC6H3)PPh2}(CO)(L)n (n = 1, L = PCy3 (4), Ph2P(CH2)3PPh2 (6); n = 2, L = PMePh2 (5)) by displacement of L*, according to the steric requirement of the incoming ligand. Similarly, complex 2 reacts with the bidentate nitrogen ligands 2-(aminomethyl)pyridine and ethylenediamine, affording the six-coordinate derivatives RuCl{(2-CH2-6-MeC6H3)PPh2}(CO)(L) (L = 2-(aminomethyl)pyridine (7), ethylenediamine (8)) in high yield. The related iodide derivative RuI{(2-CH2-6-MeC6H3)PPh2}(CO)(L*) (9) has been prepared from 2 and NaI by chloride displacement. Treatment of 2 with Na[BArf4] in the presence of 2,2‘-bipyridine or 2-(aminomethyl)pyridine gives the cationic complexes [Ru{(2-CH2-6-MeC6H3)PPh2}(CO)(L*)(L)][BArf4] (L = 2,2‘-bipyridine (10), 2-(aminomethyl)pyridine (11)), while with 3 equiv of pyridine the derivative [Ru{(2-CH2-6-MeC6H3)PPh2}(CO)(Py)3][BArf4] (12) is obtained. The structure of the δ-agostic complex 2 has been established through an X-ray crystal study, whereas the structure for 7 is supported by 2D NMR experiments in solution. Complexes 7 and 8 are active catalysts for transfer hydrogenation of ketones in 2-propanol, displaying TOF values up to 63 000 h-1.
IN VIVO IMMUNOADSORPTION OF ANTIPIG ANTIBODIES IN BABOONS USING A SPECIFIC GAL??1-3GAL COLUMN (1996)

The major role of anti-alphaGal antibodies in the hyperacute rejection of pig organs by humans and baboons has been clearly demonstrated. Spacered alpha-galactose disaccharide (Gal(alpha1)-3Gal) hapten was produced by chemical synthesis and covalently attached to a flexible, hydrophilic polymer (PAA), which in turn was covalently coupled to macroporous glass beads, forming an immunoadsorbent that is mechanically and chemically stable and can be sterilized. The extracorporeal immunoadsorption (EIA) of anti-alphaGal antibodies using this column has been investigated in vivo in 3 baboons. In Baboon 1 (which had hyperacutely rejected a pig heart transplant 4 months previously, was not splenectomized, and did not receive any pharmacologic immunosuppression) the levels of anti-alphaGal antibody and antipig IgM and IgG, as well as serum cytotoxicity, fell significantly after each of 3 EIAs but were not eliminated. Serum cytotoxicity, antipig immunoglobulin and anti-alphaGal antibody rose steeply within 24 hr of the final EIA, suggesting that the return of cytotoxicity was associated with anti-alphaGa1 antibody. In Baboons 2 and 3 (which were immunologically naive and splenectomized, and received triple drug immunosuppressive therapy) serum cytotoxicity was totally eliminated and anti-alphaGal antibody and antipig IgM and IgG levels were greatly reduced by courses of EIA. In Baboon 2, cytotoxicity and all antibody levels remained negligible for approximately one week after the final (fourth) daily EIA. In Baboon 3, cytotoxicity and antibody levels were maintained low by intermittent EIA (over a period of 13 days) for almost 3 weeks, although antipig IgM began to rebound 4 days after the final EIA. We conclude that, in an immunosuppressed, splenectomized baboon, repeated EIA using a specific alphaGal disaccharide column will reduce antipig and anti-alphaGal antibody levels and serum cytotoxicity significantly for several days. This reduction in cytotoxicity will almost certainly be sufficient to delay the hyperacute rejection of a transplanted pig organ, but further studies are required to investigate whether it will be sufficient to allow accommodation to develop.
Estimating Processing Tomato Water Consumption, Leaf Area Index, and Height Using Sentinel-2 and VENµS Imagery (2021)

Crop monitoring throughout the growing season is key for optimized agricultural production. Satellite remote sensing is a useful tool for estimating crop variables, yet continuous high spatial resolution earth observations are often interrupted by clouds. This paper demonstrates overcoming this limitation by combining observations from two public-domain spaceborne optical sensors. Ground measurements were conducted in the Hula Valley, Israel, over four growing seasons to monitor the development of processing tomato. These measurements included continuous water consumption measurements using an eddy-covariance tower from which the crop coefficient (Kc) was calculated and measurements of Leaf Area Index (LAI) and crop height. Satellite imagery acquired by Sentinel-2 and VENµS was used to derive vegetation indices and model Kc, LAI, and crop height. The conjoint use of Sentinel-2 and VENµS imagery facilitated accurate estimation of Kc (R2 = 0.82, RMSE = 0.09), LAI (R2 = 0.79, RMSE = 1.2), and crop height (R2 = 0.81, RMSE = 7 cm). Additionally, our empirical models for LAI estimation were found to perform better than the SNAP biophysical processor (R2 = 0.53, RMSE = 2.3). Accordingly, Sentinel-2 and VENµS imagery was demonstrated to be a viable tool for agricultural monitoring.
Estimation of average latent waiting and service times of activities from event logs (2015)

Analysis of performance is crucial in the redesign phase of business processes where bottlenecks are identified from the average waiting and service times of activities and resources in business processes. However, such averages of waiting and service times are not readily available in most event logs that only record either the start or the completion times of events in activities. The transition times between events in such logs are the only performance features that are available. This paper proposes a novel method of estimating the average latent waiting and service times from the transition times that employs the optimization of the likelihood of the probabilistic model with expectation and maximization EM algorithms. Our experimental results indicated that our method could estimate the average latent waiting and service times with sufficient accuracy to enable practical applications through performance analysis.
A dual refrigerator assembly for cryogen-free superconducting magnet applications (1995)

Reliable refrigeration is critical to the viability of cryogen-free superconducting magnets. The servicing of a refrigerator coldhead must not interrupt the magnet operation. A dual refrigerator coldhead assembly is described in this paper which enables the disconnection of a coldhead for servicing while a second coldhead provides continuous cooling. The two-stage Balzers UCH-130 coldheads are thermally connected to the cryostat thermal shield at the first stage and to the superconducting magnet at the second stage. The assembly includes high-T/sub c/ superconducting current leads heat stationed between the first and second stages of the coldheads in order to minimize the heat leak to the magnet. Vibration isolation components minimize the transmission of the coldhead vibration to the magnet and the thermal shield. This paper describes the design, fabrication, and testing of the dual refrigerator assembly.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Abstract IA03: Detection of tumor DNA in the saliva and plasma of patients with HNSCC (2017)

Abstract To explore the potential of tumor-specific DNA as a biomarker for head and neck squamous cell carcinomas (HNSCC), we queried DNA from saliva or plasma of 93 HNSCC patients. We searched for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and saliva were tested, tumor DNA was detected in 96% of 47 patients. The fractions of patients with detectable tumor DNA in early and late-stage disease were 100% (n = 10) and 95% (n = 37), respectively. When segregated by site, tumor DNA was detected in 100% (n = 15), 91% (n = 22), 100% (n = 7), and 100% (n = 3) of patients with tumors of the oral cavity, oropharynx, larynx, and hypopharynx, respectively. In saliva, tumor DNA was found in 100% of patients with oral cavity cancers and in 47 to 70% of patients with cancers of the other sites. In plasma, tumor DNA was found in 80% of patients with oral cavity cancers, and in 86 to 100% of patients with cancers of the other sites. Thus, saliva is preferentially enriched for tumor DNA from the oral cavity, whereas plasma is preferentially enriched for tumor DNA from the other sites. Tumor DNA in saliva was found postsurgically in three patients before clinical diagnosis of recurrence, but in none of the five patients without recurrence. Tumor DNA in the saliva and plasma appears to be a potentially valuable biomarker for detection of HNSCC. Citation Format: Nishant Agrawal. Detection of tumor DNA in the saliva and plasma of patients with HNSCC [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(23_Suppl):Abstract nr IA03.
Equipo electroacústico para la generación de altas intensidades sónicas y ultrasónicas en gases e interfases (1991)

Referencia OEPM: P8903371.-- Fecha de solicitud: 06/10/1989.-- Titular: Consejo Superior de Investigaciones Cientificas (CSIC).
Quantitative light microscopy of combined perfusion and freezing processes (1991)

The rational design of cryopreservation protocols for living tissues demands an understanding of the mechanisms of mass transport between cells and their environment throughout the entire process. We have developed a new microscope stage to enable a specimen to be viewed continuously during a preservation protocol, including the addition and removal of cryoprotective additives and freezing and thawing. The specimen is contained in a sealed chamber having inlet and outlet ports for admitting and collecting perfusate solution, the entire volume of which may be exchanged with a time constant of 1-5 s, depending on the solution viscosity. The temperature of the active area of the stage is regulated by the standard techniques of convection cryomicroscopy over a range in excess of 50 to -100 degrees C. A series of experiments has been performed on this system to measure the osmotic behaviour of rat pancreas islets during the addition and removal of dimethyl sulphoxide at temperatures between 25 and -10 degrees C. The technique involves mounting a single islet onto the low-temperature stage so that it is constrained from lateral movement by a specially sized mesh. Both the system temperature and chemical composition are monitored and controlled simultaneously and independently; as a consequence, virtually any defined cryopreservation protocol may be imposed on the specimen. For making permeability measurements, the bathing medium of the specimen may be changed very rapidly to produce a defined osmotic stress. Alternatively, the specimen may be subcooled to a specific and fixed subzero temperature, at which point ice is nucleated in the extracellular medium, creating a near instantaneous change in composition. The temporal alteration in specimen size is monitored by video microscopy and quantified by computer vision analysis methods. One of several mass transfer models is fitted to the data to estimate the membrane permeability based on the assumption of either transport dominated by the movement of water or simultaneous coupled flows of water and cryoprotective agent.
Plasmon‐Tunable Tip Pyramids: Monopole Nanoantennas for Near‐Field Scanning Optical Microscopy (2018)

Abstract Squeezing optical fields into nanometer scale is the key step to perform spatially resolved near‐field optics. In scattering‐type near‐field optical microscopy, this task is accomplished by nanoantennas that convert propagating radiation to local near‐fields and vice versa. The usual nanoantenna is composed by an elongated metal structure whose longitudinal dimension is scaled to support dipole modes of localized surface plasmon resonances. However, monopole modes can also be explored if the elongated metal nanoparticle is electrically grounded on a flat metallic plateau that acts like a mirror providing the monopole's image that closes the dipole system. Here, a method for batch production of monopole nanoantennas for scattering‐type near‐field scanning optical microscopy is presented. The nanoantennas are composed of a micropyramidal body with a nanopyramidal end whose lateral dimension can be scaled to fine‐tune localized surface plasmon resonance modes. The monopole character of the nanoantennas is revealed by electron energy loss spectroscopy, and their efficiency and reproducibility are tested in tip‐enhanced Raman spectroscopy experiments performed on single‐layer graphene and single‐walled carbon nanotubes.
CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells (2019)

Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD), which is characterized by lethal degeneration of cardiac and skeletal muscles. Mutations that delete exon 44 of the dystrophin gene represent one of the most common causes of DMD and can be corrected in ~12% of patients by editing surrounding exons, which restores the dystrophin open reading frame. Here, we present a simple and efficient strategy for correction of exon 44 deletion mutations by CRISPR-Cas9 gene editing in cardiomyocytes obtained from patient-derived induced pluripotent stem cells and in a new mouse model harboring the same deletion mutation. Using AAV9 encoding Cas9 and single guide RNAs, we also demonstrate the importance of the dosages of these gene editing components for optimal gene correction in vivo. Our findings represent a significant step toward possible clinical application of gene editing for correction of DMD.
Identification and expression analysis of leptin-regulated immediate early response and late target genes (2000)

Using PC12 cells as an in vitro model system, we have identified a series of transcripts induced through activation of the leptin receptor. On the basis of kinetic studies, two distinct gene sets could be discerned: signal transducer and activator of transciption-3 (STAT-3), suppressor of cytokine signalling-3 (SOCS-3), MT-II (metallothionein-II), the serine/threonine kinase fibroblast-growth-factor-inducible kinase (Fnk) and modulator recognition factor (MRF-1), which are immediate early response genes, and pancreatitis-associated protein I (PAP I), squalene epoxidase, uridine diphosphate glucuronosyltransferase and annexin VIII, which are late induced target genes. At late time points a strong co-stimulation with beta-nerve growth factor or with the adenylate cyclase activator forskolin was observed. To assess the validity of the PC12-cell model system, we examined the effect of leptin administration on the gene transcription of STAT-3, MT-II, Fnk and PAP I in vivo. Leptin treatment of leptin-deficient ob/ob mice increased the STAT-3, SOCS-3, MT-II and Fnk mRNA, and MT-I protein levels in liver, whereas, in jejunum, expression of PAP I mRNA was down-regulated. Furthermore, administration of leptin to starved wild-type mice enhanced the expression of MT-II and Fnk mRNA in liver, but decreased MT-II and PAP I mRNA expression in jejunum. These findings may help to explain the obese phenotype observed in some colonies of MT-I- and MT-II-null mice and/or the observation that leptin protects against tumour-necrosis-factor toxicity in vivo.
Print production designer: answering commercial/industrial print production what-ifs using simulation-as-a-service (2013)

Service level forecasting and capacity planning is uniquely challenging in commercial and industrial print service providers (PSPs) due to: 1) Large variations in supply and demand. Diverse service requests arrive stochastically; production processes heavily rely on manual work, are fault-prone and weakly structured. 2) Little or no factory audit data. Most PSPs do not have means to track production events. 3) Lack of affordable modeling tools and expertise. Many tools cost thousands of dollars and require simulation experts to spend weeks on customer sites. We developed Print Production Designer (PPD) to attack the aforementioned challenges. Powered by a custom factory dynamics simulation engine based on UC Berkeley's Ptolemy toolkit and deployed as a cloud service, PPD brings quantitative trade-offs to light, optimizes customers' information, and helps them to reach the right printing press purchasing decision. A typical PPD run costs $5.28 which is affordable for even small-sized PSPs.
Shaft Adapter For Data Coupler (1990)

Shaft adapter developed to provide means for securing Acurex 1200B universal data coupler to rotating instrumented shaft. Consists of two major parts: shaft sleeve and shaft clamp. Provides for accurate measurements of stresses and strains in shaft.
Thermally Controllable Silicon Photonic Crystal Nanobeam Cavity for for Bio-Sensing Applications (2015)

We demonstrate a photonic crystal nanobeam cavity optical device that provides heat and interrogates the refractive index. Experimental results show sensitivity of 97nm/RIU, temperature variation of ~100°C, and temperature switching time of a few µs.