gebhart/patrepeval huggingface dataset:
9,10-Dihydroplatinaanthracenes with Aromatic Diimine Ligands: Syntheses and Spectroscopic and Computational Studies of New Luminescent Materials (2008)

9,10-Dihydroplatinaanthracenes with aromatic nitrogen ligands were synthesized, derived from 2,2′-bipyridine, 4,4′-dichloro-2,2′-bipyridine, 4,4′-dimethoxy-2,2′-bipyridine, 4,4′-bis(dimethylamino)-2,2′-bipyridine, 4,4′-di-tert-butyl-2,2′-bipyridine, 1,10-phenanthroline, 2,9-dimethyl-1,10-phenanthroline, 3,4,7,8-tetramethyl-1,10-phenanthroline, and 2,2′-biquinoline. For comparison purposes, the N,N,N′,N′-tetramethylethylenediamine-derived compound was also obtained. A single-crystal X-ray structure determination was carried out on [H2C(C6H4)2]Pt(2,9-dimethyl-1,10-phenanthroline), revealing a pronounced boat conformation of the metallacyclic ring. The diimine-derived compounds are highly luminescent in the solid state at room temperature, as well as in frozen solution. The luminescent complexes are easily prepared by ligand substitution from the new organometallic platinum precursor {[H2C(C6H4)2]Pt(SEt2)}n (n = 2, 3). Spectroscopic data are provided on absorbance and emission in the UV–visible range. In order to obtain insight into orbital energies and the tunability of the optical properties, electrochemical data, as well as DFT and TD-DFT data, were obtained. The lowest-energy absorbances are due to charge transfer from orbitals located largely on the electron-rich metallacyclic ligand with some coefficient on Pt into π* orbitals of the diimine. Computations suggest that the low-energy bands mostly originate from charge transfer from the HOMO−2, HOMO−1, and HOMO to the LUMO (rarely LUMO+1 and LUMO+2) molecular orbitals. Emission maxima range from 536 to 690 nm.
FTY720 in multiple sclerosis: the emerging evidence of its therapeutic value (2006)

Based on these early results from the clinical development program, FTY720 has the potential to be an effective disease-modifying agent for the treatment of multiple sclerosis. Further results from ongoing multinational phase III studies are awaited.
Engineered Cationic Antimicrobial Peptides (eCAPs) to Combat Multidrug-Resistant Bacteria (2020)

The increasing rate of antibiotic resistance constitutes a global health crisis. Antimicrobial peptides (AMPs) have the property to selectively kill bacteria regardless of resistance to traditional antibiotics. However, several challenges (e.g., reduced activity in the presence of serum and lack of efficacy in vivo) to clinical development need to be overcome. In the last two decades, we have addressed many of those challenges by engineering cationic AMPs <i>de novo</i> for optimization under test conditions that typically inhibit the activities of natural AMPs, including systemic efficacy. We reviewed some of the most promising data of the last two decades in the context of the advancement of the field of helical AMPs toward clinical development.
Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients (2002)

Sirolimus (Rapammune, rapamycin, RAPA) is a potent immunosuppressive drug that reduces renal transplant rejection. Hyperlipidemia is a significant side effect of sirolimus treatment, and frequently leads to cardiovascular disease. This study was undertaken to determine the repeatability, reversibility, and dose dependence of the plasma lipid and apolipoprotein altering effects of sirolimus, and to elucidate the mechanism by which sirolimus induces hypertriglyceridemia in some renal transplant patients. Six patients with renal allografts maintained on cyclosporine A and prednisone were selected on the basis of their previous hyperlipidemic response to short term (14 days) sirolimus administration. For longer-term treatment, each patient was started on 10 mg/day sirolimus and continued as tolerated for 42 days to reinduce hyperlipidemia. Timed blood samples were analyzed for lipid, apolipoprotein, and sirolimus levels. During sirolimus administration, mean total plasma cholesterol increased from 214 mg/dl to 322 mg/dl (+50%; range 25-92%); LDL-cholesterol levels followed a similar pattern. Mean triglyceride level rose from 227 to 432 mg/dl (+95%; range 9-254%). ApoB-100 concentration rose from 124 to 160 mg/dl (+28%; P < 0.05). ApoC-III level increased from 28.9 to 55.5 mg/dl, +92%; (P < 0.013). These lipid and apolipoprotein changes were found to be repeatable, reversible, and dose dependent. [(13)C(4)]palmitate metabolic studies in four patients with hypertriglyceridemia indicated that the free fatty acid pool was expanded by sirolimus treatment (mean = 42.3%). Incorporation of [(13)C(4)]palmitate into triglycerides of VLDL, IDL, and LDL was decreased 38.3%, 42,1%, and 38.4%, respectively, by sirolimus treatment of these patients. These results suggest that sirolimus alters the insulin signaling pathway so as to increase adipose tissue lipase activity and/or decrease lipoprotein lipase activity, resulting in increased hepatic synthesis of triglyceride, increased secretion of VLDL, and increased hypertriglyceridemia.
A Hybrid Recommender System for Context-aware Recommendations of Mobile Applications (2007)

The goal of the work in this paper is towards the incorporation of context in recommender systems in the domain of mobile applications. The approach recommends mobile applications to users based on what other users have installed in a similar context. The idea is to apply a hybrid recommender system to deal with the added complexity of context. We have designed and realized the application to test our ideas. Users can select among several content-based or collaborative filtering components, including a rule-based module using information on point-of-interests in the vicinity of the user, and a component for the integration of traditional collaborative filtering. The implementation is integrated in a framework supporting the development and deployment of mobile services.
Immunosensor for Detection of <i>Yersinia </i><i>e</i><i>nterocolitica</i> Based on Imaging Ellipsometry (2004)

An immunosensor for the detection of pathogens was developed using imaging ellipsometry (IE) as a detection method. Yersinia enterocolitica was selected as the target pathogen in this study. A gold surface deposited with a self-assembled layer of 11-mercaptoundecanoic acid (11-MUA) was used as a substrate. For the fabrication of the immunosensor, protein G spots were made on the substrate using an inkjet-type microarrayer, and monoclonal antibody (Mab) was adsorbed onto the protein G spots. Deposition of each layer onto the substrate was confirmed by the measurement of surface plasmon resonance. The ellipsometric image of the protein G spot and the Mab-adsorbed protein G spot were acquired using an off-null ellipsometry type of imaging ellipsometry system. By measuring the ellipsometric angles of the protein layers, the surface concentration of each protein layer was calculated. The change in the mean optical intensity of the protein spot to the various concentrations of Y.enterocolitica was estimated. The immunosensor using imaging ellipsometry could successfully detect Y. enterocolitica in concentrations varying from 10(3) to 10(7) cfu/mL. The proposed immunosensor system has the advantage of allowing label-free detection, high sensitivity, and operational simplicity.
Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain (2015)

Histone deacetylase (HDAC) inhibition has promise as a therapy for Alzheimer's disease (AD) and other neurodegenerative diseases. Currently, therapeutic HDAC inhibitors target many HDAC isoforms, a particularly detrimental approach when HDAC isoforms are known to have different and specialized functions. We have developed a multiple reaction monitoring (MRM) mass spectrometry assay using stable isotope-labeled QconCATs as internal standards to quantify HDAC isoforms. We further determined a quantitative pattern of specific HDACs expressed in various human and mouse neural tissues. In human AD frontal cortex, HDAC1,2 decreased 32%, HDAC5 increased 47%, and HDAC6 increased 31% in comparison to age-matched controls. Human neural retina concentrations of HDAC1, 2, HDAC5, HDAC6, and HDAC7 decreased in age-related macular degeneration (AMD)-affected donors and exhibited a greater decrease in AD-affected donors in comparison to age-matched control neural retinas. Additionally, HDAC concentrations were measured in whole hemisphere of brain of 5XFAD mice, a model of β-amyloid deposition, to assess similarity to AD in human frontal cortex. HDAC profiles of human frontal cortex and mouse hemisphere had noticeable differences and relatively high concentrations of HDAC3 and HDAC4 in mice, which were undetectable in humans. Our method for quantification of HDAC isoforms is a practical and efficient technique to quantify isoforms in various tissues and diseases. Changes in HDAC concentrations reported herein contribute to the understanding of the pathology of neurodegeneration.
Recombinant Cellulase and Cellulosome Systems (2013)

The non-renewable fossil resources currently exploited by the oil and gas industries are the objects of growing concern owing to their finite supply and contribution to global warming. Lignocellulosic biomass is a sustainable alternative to fossil resources, and has the added advantage of not competing with human and animal nutrition. Indeed, lignocellulosic biomass, in particular its main polymer component cellulose, is a potential carbon source for the production of fuels and commodity chemicals in microbes.
Forord Børneundersøgelser - undersøgelser af børn (2017)

Traditionelle undersøgelser af børn i professionel praksis i institutioner og forvaltninger indeholder ofte vurderin- ger af børnenes evner og færdigheder inden for specifik- ke områder, f.eks. sprog, adfærd og kognition. Vanskelig- heder inden for det undersøgte område tilskrives i reglen barnet selv, og en mulig indsats er individorienteret og skal søge at rette op på en eventuel fejludvikling.
A High-Degree Photonic Cross-Connect for Transparent Networking, Flexible Provisioning &#x00026; Capacity Growth (2006)

Photonic cross-connects with duplex-port count exceeding the nodal degree enable transponder steering and span relief for traffic growth. We demonstrate a fully-loaded degree-6 PXC, supporting 2.4 Tb/s in 40 wavelengths, built from wavelength-selective switches.
Inhibition of tissue factor signaling suppresses tumor growth (2007)

Coagulation activation by tissue factor (TF) is implicated in cancer progression, cancer-associated thrombosis and metastasis. The role of direct TF signaling pathways in cancer, however, remains incompletely understood. Here we address how TF contributes to primary tumor growth by using a unique pair of isotype-matched antibodies that inhibit either coagulation (monoclonal antibody [Mab]-5G9) or direct signaling (Mab-10H10). We demonstrate that the inhibitory antibody of direct TF-VIIa signaling not only blocks TF-VIIa mediated activation of PAR2, but also disrupts the interaction of TF with integrins. In epithelial and TF-expressing endothelial cells, association of TF with beta1 integrins is regulated by TF extracellular ligand binding and independent of PAR2 signaling or proteolytic activity of VIIa. In contrast, alpha3beta1 integrin association of TF is constitutive in breast cancer cells and blocked by Mab-10H10 but not by Mab-5G9. Mab-5G9 has antitumor activity in vivo, but we show here that Mab-10H10 is at least as effective in suppressing human xenograft tumors in 2 different models. Breast tumor growth was also attenuated by blocking PAR2 signaling. These results show that tumor cell TF-PAR2 signaling is crucial for tumor growth and suggest that anti-TF strategies can be applied in cancer therapy with minor impairment of TF-dependent hemostatic pathways.
A Simple Phosphine–Oxide Host with a Multi‐insulating Structure: High Triplet Energy Level for Efficient Blue Electrophosphorescence (2011)

The perfect host? A simple phosphine–oxide host, bis{2-[di(phenyl)phosphino]phenyl}ether oxide (DPEPO) with a high triplet energy level (2.995 eV), was chosen to prove an effective strategy for multi-insulating linkage of highly efficient hosts of blue electrophosphorescence. The structure, photophysical properties, molecular orbitals, and device performance were investigated (see graphic; FMO=frontier molecular orbital). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Deposited metamaterial thin film with negative refractive index and permeability in the visible regime (2011)

Thin films are fabricated from arrays of silver nanorods with thicknesses of 160 nm and 200 nm, to function as a metamaterial. The negative refractive index and negative permeability are retrieved from measured reflection and transmission coefficients using walk-off interferometer in the visible regime. A negative-index-material thin film with negative permittivity or (and) permeability can be produced by glancing angle deposition.
An investigation into the correlation of cue phrases, unfilled pauses and the structuring of spoken discourse (1995)

Expectations about the correlation of cue phrases, the duration of unfilled pauses and the structuring of spoken discourse are framed in light of Grosz and Sidner's theory of discourse and are tested for a directions-giving dialogue. The results suggest that cue phrase and discourse structuring tasks may align, and show a correlation for pause length and some of the modifications that speakers can make to discourse structure.
Effect of additives on the digestibility of corn stover solids following pretreatment by leading technologies (2008)

Bovine serum albumin (BSA), Tween-20, and polyethylene glycol (PEG6000) were added to washed corn stover solids produced by ammonia fiber expansion (AFEX), ammonia recycled percolation (ARP), dilute sulfuric acid (DA), lime, controlled pH, and sulfur dioxide (SO(2)) pretreatments and to untreated corn stover (UT) and pure Avicel glucan prior to adding cellulase supplemented with beta-glucosidase at an activity ratio of 1:2/g and a moderate enzyme loading of 16.1 mg/g glucan in the raw corn stover. The additives were applied individually at 150, 300, and 600 mg/g glucan in the pretreated solids and in combinations of equal amounts of each that totaled 600 mg/g. The greatest increase in total sugar release was by Tween-20 with SO(2) pretreated solids followed by PEG6000 with ARP solids and Tween-20 with lime solids. The effectiveness of the additives was observed to depend on the type of sugars left in the solids, suggesting that it may be more beneficial to use the mixture of these additives to realize a high total sugar yield. In addition, little enhancement in sugar release was possible beyond a loading of 150 mg additives/g glucan for most pretreatments, and combinations did not improve sugar release much over use of additives alone for all except SO(2). Additives were also found to significantly increase concentrations of cellobiose and cellooligomers after 72 h of Avicel hydrolysis.
Feedback Regulation of Murine Pantothenate Kinase 3 by Coenzyme A and Coenzyme A Thioesters (2005)

Pantothenate kinase catalyzes a key regulatory step in coenzyme A biosynthesis, and there are four mammalian genes that encode isoforms of this enzyme. Pantothenate kinase isoform PanK3 is highly related to the previously characterized PanK1beta isoform (79% identical, 91% similar), and these two almost identical proteins are expressed most highly in the same tissues. PanK1beta and PanK3 had very similar molecular sizes, oligomeric form, cytoplasmic cellular location, and kinetic constants for ATP and pantothenate. However, these two PanK isoforms possessed distinct regulatory properties. PanK3 was significantly more sensitive to feedback regulation by acetyl-CoA (IC50 = 1 microm) than PanK1beta (IC50 = 10 microm), and PanK3 was stringently regulated by long-chain acyl-CoA (IC50 = 2 microm), whereas PanK1beta was not. Domain swapping experiments localized the difference in the two proteins to a 48-amino-acid domain, where they are the most divergent. Consistent with these more stringent regulatory properties, metabolic labeling experiments showed that coenzyme A (CoA) levels in cells overexpressing PanK3 were lower than in cells overexpressing an equivalent amount of PanK1beta. Thus, the distinct regulatory properties exhibited by the family of the pantothenate kinases allowed the rate of CoA biosynthesis to be controlled by regulatory signals from CoA thioesters involved in different branches of intermediary metabolism.
Development of sandy soil properties within subtropical residential landscapes (2023)

Abstract Urbanization is homogenizing residential developments and soils across a wide climate gradient of the United States. Land development practices commonly install landscapes on low-quality compacted fill material. While previous research shows that soil quality beneath urban lawns improves over time, studies used golf courses to represent lawns or sampled across variable development and management styles. Limited data on sandy soil quality within residential landscapes in subtropical climate warranted investigation. To evaluate the effect of age on residential soil characteristics, two residential developments from Central and Southwest Florida were selected based on known lot ages up to 31 years. Soil samples (0 to 30 cm) were collected from landscape beds and lawns, along with lawn of common areas, to evaluate bulk density and organic matter over time. Though landscape beds typically require less management, soil characteristics were similar between lawns and landscape beds, suggesting similar processes. Bulk densities decreased by 22–34% and 9–20% within the upper (0–15 cm) and lower (15–30 cm) soil depths, respectively. Upper layer soil carbon accumulation rates ranged from 0.060 to 0.156 kg C m −2 yr −1 , comparable to previous studies but did not exceed 0.021 kg C m −2 yr −1 or were not significant for greater depths. The results of this study are representative of past chronosequence studies conducted in cooler climates with fine soil texture. Sandy soil texture and warm climate do not govern carbon sequestration rates, but instead vegetation type and landscape management practices overcome these conditions.
The Evolving Role of HDL in the Treatment of High-Risk Patients with Cardiovascular Disease (2011)

Clinical trials with new HDL-raising drugs are currently under way to provide definitive evidence that increasing HDL will reduce cardiovascular events. The marked increase in our knowledge of the roles of HDL in cholesterol transport and the development of atherosclerosis now provides the framework for a more effective assessment of the plasma level and the function of HDL in an individual patient, as well as the lipoprotein profile after new drugs that increase HDL.
A knowledge-driven shared autonomy human-robot interface for tablet computers (2014)

Autonomous and teleoperated robots have been proven to be capable of solving complex manipulation tasks. However, autonomous robots can only be deployed in predefined domains and teleoperation requires full attention of a human operator. Therefore, combining autonomous capabilities of the robot with teleoperation is desirable, yet balancing the work load between robot and operator for intuitive human-robot interfaces is still an open issue. In this paper, we present a knowledge-driven tablet computer application for commanding a robot on a high level of abstraction. The application guides an operators decisions based on the actual world state of the robot and enables the operator to command object-centered actions, which are autonomously interpreted symbolically and geometrically by the robot. We evaluate our approach using the humanoid robot Rollin' Justin for an elaborate manipulation experiment and an user study. We show that our approach efficiently balances the work load between robot and operator and provides an intuitive interface for human-robot interaction.
Analysis of HF interference with application to digital communications (1983)

The paper gives measured statistics of interfering signals in the HF band, and uses these results to gain an improved understanding of the operation of various digital communication systems in the presence of interference. A novel diversity combiner and a frequency-hopping modem have been constructed using the statistics as design aids, and the systems exhibit good operation in interference.
Multi-wavelength digital in-line holographic microscopy (2012)

The use of multiple wavelength illumination in digital in-line holographic microscopy is presented. A biological sample is illuminated sequentially with three different optical sources and the separate holograms reconstructed with the appropriate wavelength. For controlling the scale of the reconstructed holograms, a reconstruction algorithm that allows for choosing the pixel size at the reconstruction plane independently of the wavelength and the reconstruction distance is used. The method is illustrated with experimental results.
Generating Illustrative Snippets for Open Data on the Web (2017)

To embrace the open data movement, increasingly many datasets have been published on the Web to be reused. Users, when assessing the usefulness of an unfamiliar dataset, need means to quickly inspect its contents. To satisfy the needs, we propose to automatically extract an optimal small portion from a dataset, called a snippet, to concisely illustrate the contents of the dataset. We consider the quality of a snippet from three aspects: coverage, familiarity, and cohesion, which are jointly formulated in a new combinatorial optimization problem called the maximum-weight-and-coverage connected graph problem (MwcCG). We give a constant-factor approximation algorithm for this NP-hard problem, and experiment with our solution on real-world datasets. Our quantitative analysis and user study show that our approach outperforms a baseline approach.
A modular HTTP adaptive streaming QoE model — Candidate for ITU-T P.1203 (“P.NATS”) (2017)

This paper describes a quality model for HTTP Adaptive Streaming. It integrates existing audio and video quality scores to a final quality estimation, factoring in quality variations over time, the recency effect, as well as location and length of buffering events at the player side. We built the model based on data gathered from more than 17 subjective quality tests. It was submitted to the ITU-T P.NATS competition; parts of it have since been released in the official recommendation ITU-T P.1203.3 as an “audiovisual quality integration module”. In the context of standardization, the model was validated on 30 subjective databases, showing high performance. Its modular approach allows its components to be re-used in other applications and combined with different temporal pooling techniques.