gebhart/patrepeval huggingface dataset:
Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat. (1995)

Nattokinase is a new fibrinolytic enzyme which cleaves directly cross-linked fibrin in vitro. In this study, we investigated the thrombolytic effect of nattokinase on a thrombus in the common carotid artery of rat in which the endothelial cells of the vessel wall were injured by acetic acid. When a section of occluded vessel was stained for CD61 antigen by immunofluorescence utilizing a monoclonal antibody, the antigen was localized around the surface of the occluded blood vessels. This result suggests that the occlusive thrombosis was caused by platelet aggregation. In addition, thrombolysis with urokinase (UK; 50000 IU/kg, i.v.) or tissue plasminogen activator (tPA; 13300 IU/kg, i.v.) in our model was observed to restore the blood flow over a 60 min monitoring period. The results indicate that our chemically induced model is useful for screening and evaluating a thrombolytic agent. We evaluated the thrombolytic activity of nattokinase using this model and compared it with fibrino(geno)lytic enzyme, plasmin or elastase. On a molar basis, the recovery of the arterial blood flow with nattokinase, plasmin and elastase were 62.0 +/- 5.3%, 15.8 +/- 0.7% and 0%, respectively. The results indicate that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo.
Cross-lingual web API classification and annotation (2011)

Abstract. Recent developments on the Web are marked by the growing support for the Linked Data initiative, which encourages government and public organisations, as well as private institutions, to expose their data on the Web. This results in a plentitude of multi-lingual document collections where the original resources are published in the language, in which they are available. The challenges of multilingualism present on the Semantic Web are also reflected in the context of services on the Web, characterised by the rapid increase in popularity and use of Web APIs, as indicated by the growing number of available APIs and the applications built on top of them. Web APIs are commonly described in plain-text as part of Web pages, following no particular guidelines and conforming to no standards, despite some initial approaches in the area [1, 2]. Therefore, API providers publish descriptions in any language they see fit, making the service discovery and the subsequent processing of the documentation challenging tasks. In this paper, we present a cross-lingual approach that calculates semantic similarity of text to help classify and annotate Web APIs, based on their textual descriptions. Furthermore, we show how our solution can be implemented as part of SWEET [3], which is a tool that enables the semi-automated creation of semantic Web API descriptions. In addition, we demonstrate how the cross-lingual approach can be adopted to support the language-independent discovery of Web APIs. 1
Deep cross-layer activation features for visual recognition (2016)

Convolutional Neural Networks (CNNs), which have nowadays dominated image analysis tasks, constitute feed-forward methods that model increasingly complex data structures and patterns along the subsequent hidden layers of the network. However, the common practice of using the activation features from the last network layer inevitably leads to a visual recognition bottleneck. This is due to the fact that discriminative features for different objects of varying complexity do not need to be extracted from the same layer. To this end, a novel frequency domain analysis of the feature maps of the same as well as of different network layers is proposed. In this way, the proposed method exploits more efficiently the knowledge that is stored in the actual CNN and facilitates in identifying the most discriminative features for every individual object type. Experimental results in a large-scale real-world Closed-Circuit Television (CCTV) surveillance and the PASCAL VOC 2012 datasets demonstrate the efficiency of the proposed approach.
Resist double patterning on BARCs and spin-on multilayer materials (2009)

Many approaches to double patterning have been devised, of which most have been designed to reduce the number of process steps. The litho-freeze-litho-etch process (LFLE) is one such technique that eliminates the first etch step from the standard litho-etch litho-etch (LELE) process. The resist freeze material chemically modifies the patterned photoresist, as well as potentially the layer beneath, which may result in a performance change at the second lithography step. Another approach, litho-process-litho-etch (LPLE) does not involve the use of a chemical freeze material, instead relying on a thermal treatment to remove excess solvent from the polymer and differential energy of activation between two resists to create a double-patterned image. Finally, double patterning using negative-tone development of a positiveacting photoresist is another approach in consideration. In this paper, we present the results of several double-patterning processes on organic bottom anti-reflective coatings (BARCs) and spin-on multilayer stacks consisting of a silicon hardmask on top of a carbon underlayer. Pattern profiles of the first and second lithography steps are compared.
Novel MoO<sub>2</sub>/carbon hierarchical nano/microcomposites: synthesis, characterization, solid state transformations and thiophene HDS activity (2012)

Novel MoO(2)/C nano/microcomposites were prepared via a bottom-up approach by hydrothermal carbonization of a solution of glucose as a carbon precursor in the presence of polyoxometalates (POMs: phosphomolybdic acid [H(3)PMo(12)O(40)] and ammonium heptamolybdate tetrahydrate [(NH(4))(6)Mo(7)O(24)]·4H(2)O). The structural characterization by FT-IR, XRPD, SEM and TEM analyses revealed the controlled formation of hierarchical MoO(2)/C composites with different morphologies: strawberry-like, based on carbon microspheres decorated with MoO(2) nanoparticles; MoO(2)/C core-shell composites; and irregular aggregates in combination with ring-like microstructures bearing amorphous Mo species. These composites can be fine-tuned by varying reaction time, glucose/POM ratio and type of POM precursor. Subsequent transformations in the solid state through calcinations of MoO(2)/C core-shell composites in air lead to hollow nanostructured molybdenum trioxide microspheres together with nanorods and plate microcrystals or cauliflower-like composites (MoO(2)/C). In addition, the MoO(2)/C composite undergoes a morphology evolution to urchin-like composites when it is calcined under nitrogen atmosphere (MoO(2)/C-N(2)). The MoO(2)/C strawberry-like and MoO(2)/C-N(2) composites were transformed into Mo carbide and nitride supported on carbon microspheres (Mo(2)C/C, MoN/C, and MoN/C-N(2)). These phases were tested as precursors in thiophene hydrodesulphurization (HDS) at 400 °C, observing the following trend in relation to the thiophene steady-state conversion: MoN/C-N(2) > MoN/C > Mo(2)C/C > MoO(2)/C-N(2) > MoO(2)/C. According to these conversion values, a direct correlation was observed between higher HDS activity and decreasing crystal size as estimated from the Scherrer equation. These results suggest that such composites represent interesting and promising precursors for HDS catalysts, where the activity and stability can be modified either by chemical or structural changes of the composites under different conditions.
High-entropy alloys: a critical assessment of their founding principles and future prospects (2016)

High-entropy alloys (HEAs) are a relatively new class of materials that have gained considerable attention from the metallurgical research community over recent years. They are characterised by their unconventional compositions, in that they are not based around a single major component, but rather comprise multiple principal alloying elements. Four core effects have been proposed in HEAs: (i) the entropic stabilisation of solid solutions, (ii) the severe distortion of their lattices, (iii) sluggish diffusion kinetics, and (iv) that properties are derived from a cocktail effect. By assessing these claims on the basis of existing experimental evidence in the literature, as well as classical metallurgical understanding, it is concluded that the significance of these effects may not be as great as initially believed. The effect of entropic stabilisation does not appear to be overarching, insufficient evidence exists to establish the strain in the lattices of HEAs, and rapid precipitation observed in some HEAs suggests their diffusion kinetics are not necessarily anomalously slow in comparison to conventional alloys. The meaning and influence of the cocktail effect is also a matter for debate.<br/>Nevertheless, it is clear that HEAs represent a stimulating opportunity for the metallurgical research community. The complex nature of their compositions means that the discovery of alloys with unusual and attractive properties is inevitable. It is suggested that future activity regarding these alloys seeks to establish the nature of their physical metallurgy, and develop them for practical applications. Their use as structural materials is one of the most promising and exciting opportunities. To realise this ambition, methods to rapidly predict phase equilibria and select suitable HEA compositions are needed, and this constitutes a significant challenge. However, whilst this obstacle might be considerable, the rewards associated with its conquest are even more substantial. Similarly, the challenges associated with comprehending the behaviour of alloys with complex compositions are great, but the potential to enhance our fundamental metallurgical understanding is more remarkable. Consequently, HEAs represent one of the most stimulating and promising research fields in materials science at present.
Selenocysteine‐Mediated Native Chemical Ligation (2001)

C-Terminal peptide thioesters are shown to react efficiently with peptide fragments containing an N-terminal selenocysteine to give selenoproteins. In analogy to the native chemical ligation of thioesters and peptides containing N-terminal cysteines, the selenol presumably attacks the thioester nucleophilically to give a selenoester intermediate that subsequently rearranges to give a native chemical bond. The utility of this procedure was demonstrated by the synthesis of a selenium-containing derivative of bovine pancreatic trypsin inhibitor (BPTI) in which Cys38 is replaced by selenocysteine. The artificial selenoprotein folds into a conformation similar to that of wild-type BPTI and inhibits trypsin and chymotrypsin with unaltered affinity.
Density-transition based electron injector for laser driven wakefield accelerators (2010)

We demonstrate a laser wakefield accelerator with a novel electron injection scheme resulting in enhanced stability, reproducibility, and ease of use. In order to inject electrons into the accelerating phase of the plasma wave, a sharp downward density transition is employed. Prior to ionization by the laser pulse this transition is formed by a shock front induced by a knife edge inserted into a supersonic gas jet. With laser pulses of 8 fs duration and with only 65 mJ energy on target, the accelerator produces a monoenergetic electron beam with tunable energy between 15 and 25 MeV and on average 3.3 pC charge per electron bunch. The shock-front injector is a simple and powerful new tool to enhance the reproducibility of laser-driven electron accelerators, is easily adapted to different laser parameters, and should therefore allow scaling to the energy range of several hundred MeV.
DNA Damage and Repair (2008)

DNA damage is a form of cell stress and injury that has been implicated in the pathogenesis of many neurologic disorders, including amyotrophic lateral sclerosis, Alzheimer disease, Down syndrome, Parkinson disease, cerebral ischemia, and head trauma. However, most data reveal only associations, and the role for DNA damage in direct mechanisms of neurodegeneration is vague with respect to being a definitive upstream cause of neuron cell death, rather than a consequence of the degeneration. Although neurons seem inclined to develop DNA damage during oxidative stress, most of the existing work on DNA damage and repair mechanisms has been done in the context of cancer biology using cycling nonneuronal cells but not nondividing (i.e. postmitotic) neurons. Nevertheless, the identification of mutations in genes that encode proteins that function in DNA repair and DNA damage response in human hereditary DNA repair deficiency syndromes and ataxic disorders is establishing a mechanistic precedent that clearly links DNA damage and DNA repair abnormalities with progressive neurodegeneration. This review summarizes DNA damage and repair mechanisms and their potential relevance to the evolution of degeneration in postmitotic neurons.
Recombinant luteinizing hormone as a survival and differentiation factor increases oocyte maturation in recombinant follicle stimulating hormone-supplemented mouse preantral follicle culture (1998)

The effects of recombinant luteinizing hormone (rLH) and recombinant follicle stimulating hormone (rFSH) both separately and together were analysed on the in-vitro maturation of a well-defined class of mouse early preantral follicles. Metaphase-II (MII) oocytes were only obtained when rLH or rFSH or a combination of both hormones was added to a standard rich culture medium at constant doses throughout the culture period. Without gonadotrophins only 8% of the follicles reached day 12 of culture. Follicle survival was optimal (between 90 and 100%) when rFSH was used; significantly fewer follicles were kept intact when rLH was added as the only supplement (54%; P < 0.001). Theca cells played a fundamental role in follicle survival when rLH was the only supplement. Presence of rLH significantly influenced the formation of antral-like cavities: on day 12, 59% of follicles cultured with rLH + rFSH had a large cavity, as compared with only 21% in cultures with rFSH only (P < 0.0001). The rHCG stimulated germinal vesicle breakdown rate from the different gonadotrophin-supplemented cultures on day 12 was not significantly different (FSH: 89%; LH: 70%; FSH/LH: 83%). However, addition of rLH to rFSH did significantly improve (P < 0.05) the completion of the first meiotic division up to the MII stage (FSH: 46%; LH: 39%; FSH/LH: 76%). Interfollicle differences in steroid production were very large and depended on the presence of theca cells and on the kind of gonadotrophin supplemented. Without theca cells, oestrogen concentrations in rFSH-supplemented cultures were 100 times lower than their theca-containing counterparts during the entire culture period. From culture day 9 onwards most conditioned media had increased basal progesterone concentrations. This study points up the in-vitro role of LH on the differentiation of follicle-like structures and the oocyte's meiotic maturation and suggests an important role for theca cells in providing modulators of in-vitro gonadotrophin action.
Al – Si multilayers: A synthetic material with large thermoelectric anisotropy (2004)

A synthetic material with large thermoelectric anisotropy has been prepared from a metal–semiconductor multilayer structure. By an alloying process, a multilayer stack A–B–A…, where A and B are pure aluminum and n-silicon, is produced with a thermoelectric anisotropy ΔS=S‖−S⊥≅1.5mV∕K, where S‖ and S⊥ are the absolute Seebeck coefficients along and perpendicular to the layers, respectively. The use of this synthetic material for light sensing applications is demonstrated.
Topotecan Use for Second-Line Treatment in Patients with Recurrent or Metastatic Cervical Cancer at Brazilian National Cancer Institute (INCA) (2013)

Objective: Cervical cancer represents the third most commonly diagnosed cancer and is an important cause of death for women suffering with malignancies. Patients who are refractory or progressed after first-line palliative treatment have a dismal prognosis and no second-line chemotherapy is considered standard so far. Several agents have been investigated in this setting and topotecan is one of the most characterized. The objective of this study was to evaluate response rate (RR), progression-free survival (PFS), overall survival (OS) and toxicity of topotecan in second palliative line for cervical cancer. Methods: An analysis was performed of all patients with recurrent or metastatic cervical cancer treated with topotecan in second palliative line at Brazilian National Cancer Institute, between 2008 and 2010. Results: A total of 73 courses of topotecan were given in the current study (median: 3.5 cycles; range 1 - 6). Anemia was the most frequent adverse event (grade 2:35%; grade 3:30%). Of the 20 patients evaluable, there were 2 partial responders to the treatment. The overall response rate (ORR) was 10%; 3 patients (15%) had stable disease as maximum response. The median PFS for the entire group was 2.93 months (95% CI 2.41 - 3.45) and OS was 4.66 months (95% CI 1.21 - 8.11). Conclusion: The limited activity of topotecan schemas in second-line treatment of cervical cancer and the associated overall toxicity may not justify their use in this setting. Patients who progress after first-line treatment may be offered participation in clinical trials, other second-line agents or best supportive care measures.
Collagen matrix as a tool in studying fibroblastic cell behavior (2015)

Type I collagen is a fibrillar protein, a member of a large family of collagen proteins. It is present in most body tissues, usually in combination with other collagens and other components of extracellular matrix. Its synthesis is increased in various pathological situations, in healing wounds, in fibrotic tissues and in many tumors. After extraction from collagen-rich tissues it is widely used in studies of cell behavior, especially those of fibroblasts and myofibroblasts. Cells cultured in a classical way, on planar plastic dishes, lack the third dimension that is characteristic of body tissues. Collagen I forms gel at neutral pH and may become a basis of a 3D matrix that better mimics conditions in tissue than plastic dishes.
Role of Trench Bottom Shielding Region on Switching Characteristics of 4H-SiC Double-Trench Mosfets (2018)

The effect of a gate trench bottom p + region (BPR) on the dynamic characteristics of 4H-SiC double-trench MOSFETs was investigated. Although employing a BPR led to an improved trade-off in the static characteristics, a BPR adversely affected the switching characteristics in spite of a reduction in the Miller capacitance compared to the case without a BPR . Simulation analysis revealed that a resistance between a BPR and a source electrode led to an increase in the switching loss. We have found reduction of the resistance is insufficient in order to provide benefits from the BPR. Hence, it is necessary to improve layouts of contacts of the BPR to the source electrode.
Current assisted photonic mixing demodulator implemented in 0.18&#x03BC;m standard CMOS technology (2009)

CMOS image sensors integrate the image processing circuitry on the same chip as the light sensitive elements. Recently, lots of effort has been concentrated to create a standard CMOS photonic demodulator. A CMOS based current assisted photonic mixing demodulator is described in this paper. As a test vehicle, 10 times 10 pixel arrays in two different geometries have been fabricated with a 0.18 mum CMOS technology. Remarkably small pixel size of 10 times 10 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> has been achieved. Preliminary experimental results demonstrate a good DC charge separation efficiency close to 100% and good demodulation capabilities up to 35 MHz. The measurement results are compared to the performance of two different device array structures. These test devices represent the first step towards integrating a high resolution TOF based 3D CMOS image sensor.
Analysis of secondary organic aerosols in air using extractive electrospray ionization mass spectrometry (EESI-MS) (2012)

Extractive electrospray ionization mass spectrometry (EESI-MS) has been shown, in other laboratories, to be a useful technique for the analysis of aerosols from a variety of sources. EESI-MS is applied here, for the first time, to the analysis of secondary organic aerosol (SOA) formed from the reaction of ozone and α-pinene. The results are compared to those obtained using atmospheric pressure chemical ionization mass spectrometry (APCI-MS). The SOA was generated in the laboratory and merged with electrospray droplets. The recovered ions were directed towards the inlet of a triple quadrupole mass spectrometer. Through the use of a denuder to remove gas phase compounds, the EESI-MS technique was found to be effective for measuring the major ozonolysis products either in particles alone or in a combination of vapor phase and particulate products. Due to its relatively simple setup and the avoidance of sample collection and work-up, EESI-MS shows promise as an excellent tool for the characterization of atmospherically relevant particles.
[Effect of methyluracil on lipid peroxidation in the plasma and tissue homogenates from ulcer lesions of the gastric wall in rats]. (1987)

Dynamics of experimental acetate gastric ulcer healing and lipid peroxidation were studied in rat blood and gastric tissues after treatment with methyluracil. The drug was shown to stimulate reparation and to inhibit lipid peroxidation. The antiulcerogenous effects of methyluracil appear to involve the antioxidative mechanisms.
A simplified method for detecting cytomegalovirus by polymerase chain reaction from histologic sections of small biopsies. (1992)

Using a simplified procedure, we have extracted DNA from unstained paraffin sections of needle biopsies of kidney and liver transplants and identified the presence of CMV using the polymerase chain reaction. This method utilizes oligonucleotide primers for two genes shown to be specific for cytomegalovirus (CMV) as well as an internal control gene (hemoglobin) in a single reaction. Utilizing nested PCR amplification with agarose gel electrophoresis, CMV can be detected without radioisotopes to a level of sensitivity equivalent to one one-hundredth of a cytomegalic virocyte per cm2 of a 3-microM paraffin section. This method is applicable to situations where only scarce paraffin-embedded tissue is available.
<i>TRK1</i> and <i>TRK2</i> Encode Structurally Related K <sup>+</sup> Transporters in <i>Saccharomyces cerevisiae</i> (1991)

We describe the cloning and molecular analysis of TRK2, the gene likely to encode the low-affinity K+ transporter in Saccharomyces cerevisiae. TRK2 encodes a protein of 889 amino acids containing 12 putative membrane-spanning domains (M1 through M12), with a large hydrophilic region between M3 and M4. These structural features closely resemble those contained in TRK1, the high-affinity K+ transporter. TRK2 shares 55% amino acid sequence identity with TRK1. The putative membrane-spanning domains of TRK1 and TRK2 share the highest sequence conservation, while the large hydrophilic regions between M3 and M4 exhibit the greatest divergence. The different affinities of TRK1 trk2 delta cells and trk1 delta TRK2 cells for K+ underscore the functional independence of the high- and low-affinity transporters. TRK2 is nonessential in TRK1 or trk1 delta haploid cells. The viability of cells containing null mutations in both TRK1 and TRK2 reveals the existence of an additional, functionally independent potassium transporter(s). Cells deleted for both TRK1 and TRK2 are hypersensitive to low pH; they are severely limited in their ability to take up K+, particularly when faced with a large inward-facing H+ gradient, indicating that the K+ transporter(s) that remains in trk1 delta trk2 delta cells functions differently than those of the TRK class.