gebhart/patrepeval huggingface dataset:
An adjuvanted zoster vaccine elicits potent cellular immune responses in mice without QS21 (2022)

Herpes zoster (HZ) is caused by reactivation of latent varicella-zoster virus (VZV) when VZV-specific cellular immunity is insufficient to control reactivation. Currently, Shingrix, which contains the VZV gE protein and GSK's AS01<sub>B</sub> adjuvant composed of liposomes formulated with cholesterol, monophosphoryl lipid A (MPL) and QS21, is used for prevention of HZ. However, reactogenicity to Shingrix is common leading to poor patient compliance in receiving one or both shots. Here, we evaluated the immunogenicity of a newly formulated gE protein-based HZ vaccine containing Second-generation Lipid Adjuvant (SLA), a synthetic TLR4 ligand, formulated in an oil-in-water emulsion (SLA-SE) without QS21 (gE/SLA-SE). In VZV-primed mouse models, gE/SLA-SE-induced gE-specific humoral and cellular immune responses at comparable levels to those elicited by Shingrix in young mice, as both gE/SLA-SE and Shingrix induce polyfunctional CD4<sup>+</sup> T-cell responses. In aged mice, gE/SLA-SE elicited more robust gE-specific T-cell responses than Shingrix. Furthermore, gE/SLA-SE-induced T-cell responses were sustained until 5 months after immunization. Thus, QS21-free, gE/SLA-SE is a promising candidate for development of gE-based HZ vaccines with high immunogenicity-particularly when targeting an older population.
A New Series of Pyridinone Derivatives as Potent Non-Nucleoside Human Immunodeficiency Virus Type 1 Specific Reverse Transcriptase Inhibitors (1995)

4-(Arylthio)-pyridin-2(1H)-ones variously substituted in their 3-, 5-, and 6-positions have been synthesized as a new series of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)-pyridinone hybrid molecules. Biological studies revealed that some of them show potent HIV-1 specific reverse transcriptase inhibitory properties. Compounds 16 and 7c, the most active ones, inhibit the replication of HIV-1 at 3 and 6 nM, respectively.
Myocardial fibrosis: role of angiotensin II and aldosterone (1993)

In this report we review the replacement (i.e., scarring) and reactive (i.e., perivascular and interstitial fibrosis) fibrous tissue responses found in the myocardium in response to effector hormones of the renin-angiotensin-aldosterone system. Experimental data are presented to indicate: a) endogenous or exogenous elevations in plasma angiotensin II are associated with acute cardiac myocyte necrosis and subsequent microscopic scarring; b) chronic elevations in plasma aldosterone (ALDO), relative to Na+ intake, are associated with a perivascular and interstitial fibrosis of the coronary and systemic circulations and are also seen in response to chronic administration of the mineralocorticoid hormone deoxycorticosterone (DOC); and c) chronic mineralocorticoid excess, due to ALDO or DOC, is associated with enhanced urinary K+ excretion, cardiac myocyte necrosis and scarring. Pharmacologic agents which interfere with these effector hormones (e.g., ACE inhibition and ALDO receptor antagonism) protect the myocardium against this pathologic structural remodeling created by the reactive and replacement (reparative) fibrosis. Evidence is also presented to indicate that chronic ACE inhibition is associated with a regression in reactive myocardial fibrosis. Based on these experimental findings we would suggest that clinical trials are indicated to address the prevention and regression of myocardial fibrosis--an important determinant of pathologic structural remodeling and abnormal myocardial stiffness.
Fast error diagnosis for combinational verification (2002)

We address the problem of localizing error sites in a combinational circuit that has been shown to be inequivalent to its specification. In the typical case, it is not possible to identify the error location exactly. We propose a novel diagnosis strategy of gradually increasing the level of detail in the analysis algorithm to ultimately derive a small list of potential error sites in a short time. Our techniques combine the use of simulation, BDDs, and SAT in a novel way to achieve the goal. A limitation of many previous approaches has been that they have been constrained to a specific error model. No such assumption is made in our work. We show through experimental results that these techniques are successful in that the final set of error sites derived is small, contains the actual error sites and is derived in a reasonable amount of time.
<title>Synchrotron Radiation And Its Application To Digital Subtraction Angiography</title> (1981)

The intense synchrotron radiation produced at electron storage rings provides a new source of X-rays highly suited to iodine K-edge digital subtraction angiography. The high intensity and small angular divergence permit the radiation to be monochromatized by Bragg diffraction and made available in beams of small vertical size, of arbitrary horizontal width, and of tunable energy. The use of such beams provides maximum sensitivity to intra-arterial iodine and virtually eliminates image contrast due to non-vascular body structures. The sensitivity of this method to iodine offers the prospect of visualizing arteries by peripheral venous injection.
Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura (2007)

Gene copy number variation (CNV) and single nucleotide polymorphisms (SNPs) count as important sources for interindividual differences, including differential responsiveness to infection or predisposition to autoimmune disease as a result of unbalanced immunity. By developing an FCGR-specific multiplex ligation-dependent probe amplification assay, we were able to study a notoriously complex and highly homologous region in the human genome and demonstrate extensive variation in the FCGR2 and FCGR3 gene clusters, including previously unrecognized CNV. As indicated by the prevalence of an open reading frame of FCGR2C, Fcgamma receptor (FcgammaR) type IIc is expressed in 18% of healthy individuals and is strongly associated with the hematological autoimmune disease idiopathic thrombocytopenic purpura (ITP) (present in 34.4% of ITP patients; OR 2.4 (1.3-4.5), P < .009). FcgammaRIIc acts as an activating IgG receptor that exerts antibody-mediated cellular cytotoxicity by immune cells. Therefore, we propose that the activating FCGR2C-ORF genotype predisposes to ITP by altering the balance of activating and inhibitory FcgammaR on immune cells.
Serologic and Genetic Identification of Peromyscus maniculatus as the Primary Rodent Reservoir for a New Hantavirus in the Southwestern United States (1994)

An outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was etiologically linked to a newly recognized hantavirus. Knowledge that hantaviruses are maintained in rodent reservoirs stimulated a field and laboratory investigation of 1696 small mammals of 31 species. The most commonly captured rodent, the deer mouse (Peromyscus maniculatus), had the highest antibody prevalence (30%) to four hantavirus antigens. Antibody also was detected in 10 other species of rodent and in 1 species of rabbit. Reverse transcriptase-polymerase chain reaction (RT-PCR) products of hantavirus from rodent tissues were indistinguishable from those from human HPS patients. More than 96% of the seropositive P. maniculatus were positive by RT-PCR, suggesting chronic infection. Antibody prevalences were similar among P. maniculatus trapped from Arizona (33%), New Mexico (29%), and Colorado (29%). The numeric dominance of P. maniculatus, the high prevalence of antibody, and the RT-PCR findings implicate this species as the primary rodent reservoir for a new hantavirus in the southwestern United States.
Exploiting location awareness toward improved wireless system design in cognitive radio (2008)

Rapid advances in digital technology allow people to have a single wireless device that has multiple functions such as communication, computing, and entertainment. These functions are generally embedded into the devices as add-on hardware components such as sensors, digital cameras, and so on. Currently, the functions operate independent of each other, since there is no unit that controls and coordinates the add-on hardware. However, with the aid of a cognitive engine, CR can take advantage of each component to improve its communications. In this work, location awareness is exploited to improve the wireless communication system design in CR. It is shown that several crucial wireless channel parameters are environment-dependent. In order for CR to relate a corresponding empirical model with an environment, the classification of propagation environments is outlined as well. The methods of characterizing the propagation environment for CR are also discussed. In addition, it is described how CR can carry out all these steps with the aid of a KRS along with RKRL and complete its adaptation cycle. CR networks are also discussed, including disseminating the location awareness information, propagation characteristics, and their effects on the network itself.
Exceptionally high voltage Schottky diamond diodes and low boron doping (2003)

Exceptionally pure epitaxial diamond layers have been grown by microwave plasma chemical vapour deposition, which have low boron doping, from 5 × 1014 to 1 × 1016 cm−3, and the compensating n-type impurities are the lowest reported for any semiconducting diamond, <3 × 1013 cm−3. The hydrogen impurities that bind with the boron making them electrically inactive can be significantly reduced by baking the diamond to >700 °C for ∼1 s in air. Schottky diodes made on these epitaxial diamond films have breakdown voltages >6 kV, twelve times the highest breakdown voltage reported for any diamond diode and higher than any other semiconductor Schottky diode.
Novel millimeter-wave near-field resistivity microscope (1996)

We demonstrate a technique for contactless mapping of resistivity or dielectric constant of surfaces and films with a spatial resolution better than 100 μm. This technique may be used for the nondestructive testing of semiconducting wafers, conducting polymers, oxide superconductors, and printed circuits. The principle of operation consists of the scanning of a tiny millimeter-wave antenna at a very small height above an inhomogeneous conducting surface and measuring the intensity and phase of the reflected (transmitted) wave. We use a specially designed resonant slit antenna and achieve subwavelength spatial resolution of λ/50.
Novel Ionic Liquids Based Electrolytes for Secondary Lithium-Ion Batteries (2013)

This manuscript reports typical galvanostatic charge/discharge efficiency of Cgr/LiFePO 4 and Li 4 Ti 5 O 12 /LiFePO 4 cells. In this study, we examined the electrochemical performances of various ionic liquids C 1 C 3 RIm-NTf 2 (R= -CH 3 or -CN) with different carbonate additives (VC and VEC) versus different electrodes as new safe-stable electrolytes for lithium-ion secondary batteries. The cyclic performance was performed at constant (C/10) and various current rates (C/20, C/10, C/5, C/2, C, 2C, and 5C) at 60°C.
Ventricular Tachycardia Detection Using Bipolar Electrogram Analysis is Site Specific (1992)

While algorithms for bipolar intraventricular electrogram analysis have potential use in complementing rate criteria for ventricular tachycardia (VT) detection by implantable antitachycardia devices, the sensitivity of such algorithms to the intracavitary site of electrogram detection has not been determined. In this study, unfiltered (1-500 Hz) electrograms were recorded from a bipolar electrode catheter initially positioned at the right ventricular (RV) apex (site 1) of 12 patients during sinus rhythm (SR1) and during induced monomorphic VT (VT1). Sinus rhythm (SR2) and the identical VT (VT2) were recorded a second time after repositioning the same electrode catheter within the RV apex (site 2) 7-44 mm (mean +/- SD = 15 +/- 10) from its original site. The data were digitized at 1,000 Hz. Templates from SR1 and SR2, respectively, were compared subsequently with individual intraventricular electrograms from 15-25 sec passages of SR1 and VT1 and SR2 and VT2, respectively, using correlation waveform analysis. At site 1, the mean patient correlation coefficient ranged from 0.982-0.998 during SR1 and 0.062-0.975 during VT1. At site 2, the mean patient correlation coefficient ranged from 0.995-0.998 during SR2 and 0.113-0.983 during VT2. Using a correlation threshold of 0.9, VT was differentiated from SR in 11/12 patients (91%) overall: 8/12 patients (67%) at site 1, 9/12 patients (75%) at site 2, and 6/12 patients (50%) at both sites. Thus, while discrimination of VT from SR is feasible with morphological analysis of bipolar right ventricular intracavitary electrograms, the accuracy of bipolar intraventricular electrogram analysis may depend upon intracavitary electrode location in selected patients.
ChemInform Abstract: A NEW SYNTHESIS OF 2,5‐DIMETHYL‐3(2H)‐FURANONE (1978)

Abstract Die alkalische Dimerisierung von 2,3‐Butandion (I) führt zum Hydroxytetrahydrofuranon (II), das beim Erhitzen in Gegenwart von Säure zum 2,5‐Dimethyl‐3‐furanon (III) spaltet.
The IL-2/IL-2 Receptor System. Involvement of a Novel Receptor Subunit, .GAMMA. Chain, in Growth Signal Transduction. (1992)

We previously demonstrated the existence of a third component, p64, of IL-2 receptor (IL-2R), tentatively named the gamma chain of IL-2R. Our recent studies provided evidence suggesting that the gamma chain endows the beta chain of IL-2R with IL-2 binding ability. The gamma chain was detected in lymphoid transfectants of IL-2R beta cDNA, which showed the intermediate-affinity IL-2R, but not in nonlymphoid transfectants of IL-2R beta cDNA, which showed no IL-2 binding activity. The comparative study between two subclones of lymphoid MOLT4 transfectant of IL-2R beta cDNA demonstrated that the amount of the gamma chain coprecipitated with IL-2R beta was proportional to numbers of the IL-2 binding sites. These results suggest the possibility that the gamma chain associates with IL-2R beta and has an important role in formation of the intermediate-affinity IL-2R complex. On the other hand, we have also demonstrated the association of IL-2R beta with a certain tyrosine kinase, of which activation by IL-2 could be indispensable process at the initial pathway of signal transduction.
Molten salt destruction as an alternative to open burning of energetic material wastes (1994)

LLNL has built a small-scale (about 1 kg/hr throughput unit to test the destruction of energetic materials using the Molten Salt Destruction (MSD) process. We have modified the unit described in the earlier references to inject energetic waste material continuously into the unit. In addition to the HMX, other explosives we have destroyed include RDX, PETN, ammonium picrate, TNT, nitroguanadine, and TATB. We have also destroyed a liquid gun propellant comprising hydroxyl ammonium nitrate, triethanolammonium nitrate and water. In addition to these pure components, we have destroyed a number of commonly used formulations, such as LX-10 (HMX/Viton), LX-16 (PETN/FPC461, LX-17 (TATB/Kel F), and PBX-9404 (HMX)/CEF/Nitro cellulose). Our experiments have demonstrated that energetic materials can be safely and effectively treated by MSD.We have also investigated the issue of steam explosions in molten salt units, both experimentally and theoretically, and concluded that steam explosions can be avoided under proper design and operating conditions. We are currently building a larger unit (nominal capacity 5 kg/hr,) to investigate the relationship between residence time, temperature, feed concentration and throughputs, avoidance of back-burn, a;nd determination of the products of combustion under different operating conditions.
Downhole seismic source (1987)

Abstract A prototype model of a downhole controlled seismic source has been built and field tested. This instrument is a swept-frequency, pneumatically powered seismic source that operates in the 10 to 100 Hz range. This particular version is a vertical-dipole source and generates vertically polarized shear waves. The instrument is an improved version of a downhole monofrequency source first tested in the crust of Kilauea Lava Lake, Hawaii, in 1981. The present prototype source was field tested recently at the Chevron Oil Field Research facility in La Habra, California. Data from this test, combined with calculations for a full-scale instrument, indicate that considerable amounts of energy can be coupled into the ground with this type of downhole source. Signals from these prototype sources are easily detectable at distances of 150 m or more. A larger version of the source is currently being designed and fabricated for use in 0.20 m diameter holes, and it will theoretically have a range 30 times greater than the current prototype model. This new seismic source has applications in scientific studies related to the Continental Scientific Drilling Program. The source also has applications in locating magma bodies for the Magma Energy Program and in evaluating oil reservoirs.
Opportunistic Channel Estimation for Implicit 802.11af MU-MIMO (2016)

Multi-User MIMO (MU-MIMO) linear channel coding can greatly increase wireless system capacity when Stations (STAs) have fewer antennas than the Access Point (AP), but it comes at the cost of significant Channel State Information (CSI) estimation overhead. Previous work has suggested that 802.11af MU-MIMO systems might benefit from long channel coherence time, extending the useful duration of CSI. In this paper, we propose and analyze an opportunistic channel sounding policy that avoids sounding overhead in wireless channels by gathering implicit CSI opportunistically. This policy not only avoids CSI overhead, but also has the potential to enable efficient interoperability of multi-user APs with legacy single-stream STAs. To investigate the performance of this new policy, we implement a new mobile channel sounding framework on a custom 802.11af Software-Defined Radio (SDR) system designed for UHF-band experimentation and evaluate channel sounding performance in indoor and outdoor environments under various mobility modes. Additional protocol analysis shows that in UHF channels with sufficient channel coherence time, an opportunistic channel sounding policy offers significant protocol optimization while improving the scalability of next-generation MU-MIMO systems.
Schistoma Mansoni Soluble Egg Antigens: Determination of the Stage and Species Specificity of their Serologic Reactivity by Radioimmunoassay (1976)

Three highly purified Schistosoma mansoni egg antigens reactivity with sera from mice with chronic schistosomiasis mansoni (major serologic antigens-MSA1, MSA2, and MSA3) were utilized in radioimmunoassays for determining their stage and species specificity. Inhibition studies revealed that MSA1 was completely stage specific, since its binding to S. mansoni chronic infection serum (CIS) could not be inhibited either with cercarial or adult worm antigen. MAS2 and MSA3 were specific with regard to adult worm antigen but their binding to CIS was slightly inhibited by cercarial antigen. Immature eggs in comparison with mature eggs contained only negligible amounts of MSA1 whereas MSA2 and MSA3 were present in large quantities. Fluid from eggs hatched in spring water (hatch fluid-HF) contained considerable amounts of MSA1 as well as MSA2 and MSA3. With regard to species specificity, MSA1 essentially did not cross-react with crude soluble egg antigen (SEA) from Schistosoma japonicum and Schistosoma haematobium whereas MSA2 and MSA3 showed partial cross-reactivity. Antibody dilution studies with sera from animals and humans infected with heterologous schistosome species (i.e., S. japonicum and S. haematobium) indirectly confirmed the high degree of species specificity of MSA1. The degree of serologic specificity of MSA1 as demonstrated in this study parallels that of the sensitizing activity of S. mansoni eggs and SEA for granuloma formation, as demonstrated in previous investigations. This study, therefore, indicates that MSA1 may be a major immunopathologically active egg antigen. In addition, the high degree of species specificity of MSA1 suggests its use in the serodiagnosis of schistosomiasis mansoni.
Growth and characterization of diamond films on nondiamond substrates for electronic applications (1991)

Recent advances in the chemical vapor deposition (CVD) and characterization of diamond films on nondiamond substrates are reviewed. Major growth techniques, including hot filament CVD; microwave, RF, or DC plasma enhanced CVD; and combustion flame growth; as well as a number of hybrid and novel approaches, are described and analyzed. Results from the major categories of diamond film characterization, including diamond phase identification, nucleation and interfacial phenomena, morphology, and defects, as well as their correlations with electrical properties, are examined and discussed. Although most of the information presented is equally applicable to protective and wear-resistant coating application, emphasis is placed in the areas most pertinent to microelectronics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from<i>Amycolatopsis mediterranei</i> (1998)

The 54-kbp Type I polyketide synthase gene cluster, most probably involved in rifamycin biosynthesis by Amycolatopsis mediterranei, was cloned in E. coli and completely sequenced. The DNA encodes five closely packed, very large open reading frames reading in one direction. As expected from the chemical structure of rifamycins, ten polyketide synthase modules and a CoA ligase domain were identified in the five open reading frames which contain one to three polyketide synthase modules each. The order of the functional domains on the DNA probably reflects the order in which they are used because each of the modules contains the predicted acetate or propionate transferase, dehydratase, and beta-ketoacyl-ACP reductase functions, required for the respective step in rifamycin biosynthesis.
Adaptive Frequency-Domain RLS DFE for Uplink MIMO SC-FDMA (2014)

It is well known that, in the case of highly frequency-selective fading channels, the linear equalizer (LE) can suffer significant performance degradation compared with the decision feedback equalizer (DFE). In this paper, we develop a low-complexity adaptive frequency-domain DFE (AFD-DFE) for single-carrier frequency-division multiple-access (SC-FDMA) systems, where both the feedforward and feedback filters operate in the frequency domain and are adapted using the well-known block recursive least squares (RLS) algorithm. Since this DFE operates entirely in the frequency domain, the complexity of the block RLS algorithm can be substantially reduced when compared with its time-domain counterpart by exploiting a matrix structure in the frequency domain. Furthermore, we extend our formulation to multiple-input-multiple-output (MIMO) SC-FDMA systems, where we show that the AFD-DFE enjoys a significant reduction in computational complexity when compared with the frequency-domain nonadaptive DFE. Finally, extensive simulations are carried out to demonstrate the robustness of our proposed AFD-DFE to high Doppler and carrier frequency offset (CFO).