gebhart/patrepeval huggingface dataset:
XQuery at your web service (2004)

XML messaging is at the heart of Web services, providing the flexibility required for their deployment, composition, and maintenance. Yet, current approaches to Web services development hide the messaging layer behind Java or C# APIs, preventing the application to get direct access to the underlying XML information. To address this problem, we advocate the use of a native XML language, namely XQuery, as an integral part of the Web services development infrastructure. The main contribution of the paper is a binding between WSDL, the Web Services Description Language, and XQuery. The approach enables the use of XQuery for both Web services deployment and composition. We present a simple command-line tool that can be used to automatically deploy a Web service from a given XQuery module, and extend the XQuery language itself with a statement for accessing one or more Web services. The binding provides tight-coupling between WSDL and XQuery, yielding additional benefits, notably: the ability to use WSDL as an interface language for XQuery, and the ability to perform static typing on XQuery programs that include Web service calls. Last but not least, the proposal requires only minimal changes to the existing infrastructure. We report on our experience implementing this approach in the Galax XQuery processor.
Progress and developments in the turbo Grignard reagent i-PrMgCl·LiCl: a ten-year journey (2015)

Over the past decade, the effectiveness of i-PrMgCl·LiCl has been constantly highlighted by a number of research groups. Its enhanced nucleophilicity brings prosperity to highly functionalized Grignard reagents, other useful bimetallic (alkali-metal) agents and nucleophilic alkylation products under mild reaction conditions. In this feature article, a comprehensive, systematical and in-depth overview of i-PrMgCl·LiCl is provided in a multidisciplinary idea. It involves the structural and kinetic perspectives of i-PrMgCl·LiCl as well as its unique reactivity and selectivity, with knowledge of the former helping to rationalize trends of the later.
An Advanced Vehicle Collision Warning Algorithm over the DSRC Communication Environment: An Advanced Vehicle Collision Warning Algorithm (2013)

Although many kinds of collision pre-warning algorithms and systems for vehicles were proposed in order to prevent accidents in past years, two problems have to be resolve in order to enhance the accuracy of collision detection. First, a vehicle does not always keep the same velocity when it is moving. Second, the curve road condition should be considered. In this paper, we proposed an Advanced Cooperative Collision Warning algorithm named ACCW to deal with these two problems. Basically, ACCW uses the acceleration parameter to correct some errors that are caused by velocity and direction changing. The simulation results show that that the proposed ACCW algorithm has high accuracy's warning rates in both intersection and curve situations.
LFA-1 and CD2 Synergize for the Erk1/2 Activation in the Natural Killer (NK) Cell Immunological Synapse (2009)

Natural killer (NK) cell recognition and formation of a conjugate with target cells, followed by intracellular signal pathway activation and degradation of cytolytic granules, are essential for NK cell cytotoxicity. In this study, NK92 cells were used to investigate synapse formation and subsequent signaling after binding to the target cell. The binding rate of the NK92-target cell was associated with NK92 cell cytotoxicity. Confocal results showed that adhesion molecules, LFA-1 (CD11a) and CD2, accumulated at the interface of the NK92-K562 contact. Ligation with K562 cells activated the Erk1/2 signal pathway of NK92 cells. The blocking of the NK-target conjugate by EDTA or anti-CD11a or/and anti-CD2 antibody decreased the phosphorylation of Erk1/2 and NK cell cytotoxicity. Inhibition of Erk1/2 phosphorylation by the chemical inhibitor U0126 suppressed the cytolytic activity of NK92 cells, but had no effect on NK-target conjugate formation. Thus, conjugate formation of the NK92-target cell was prerequisite to NK cell activation, and subsequent signal transduction was also required for NK cell cytotoxicity.
Habituation, prepulse inhibition, fear conditioning, and drug modulation of the acoustically elicited pinna reflex in rats. (1986)

A reliable component of the acoustic startle response in animals is a flexion of the ears, the pinna reflex. One goal of the present investigation was to develop a preparation and apparatus suitable for analyzing the pinna reflex in the awake rat. A second goal was to examine the pinna reflex under behavioral and pharmacological conditions known to affect other response systems, such as whole-body startle, and determine whether the pinna response is a valid model for analyzing behavioral plasticity. The amplitude of the pinna reflex in spinally transected rats was directly related to stimulus intensity and exhibited short-term habituation, prepulse inhibition, and enhancement by prior fear conditioning. Also, pinna response amplitude increased following systemic administration of strychnine and was decreased following clonidine. It is concluded that this preparation and response system are valid for studying various forms of behavioral modification. Implications of these findings are discussed in terms of the potential utility of this response system in investigating the cellular correlates of behavioral plasticity in mammals.
Cenicriviroc, an orally active CCR5 antagonist for the potential treatment of HIV infection. (2010)

Treatment of HIV-1-infected individuals is often complicated by the development of antiretroviral resistance, and novel antiretroviral agents with unique mechanisms of action and resistance profiles are needed to address this issue. CCR5 inhibitors represent a new class of antiretroviral agents that block the CCR5 receptor and prevent HIV-1 recognition and entry into CD4+ macrophages and T-cells. Tobira Therapeutics Inc is developing cenicriviroc (TBR-652, formerly TAK-652), a potent inhibitor of CCR5-tropic HIV-1 replication. Cenicriviroc has good oral bioavailability, a long t1/2 that allows once-daily dosing, and has demonstrated excellent antiviral potency with minimal toxicity in in vitro studies and phase I clinical trials. Encouraging efficacy results have been reported from phase II clinical trials in patients with CCR5-tropic HIV-1. The drug is also an inhibitor of the CCR2 receptor, which is known to be associated with inflammatory-related disease states, leading to Tobira initiating a phase I clinical trial in patients with rheumatoid arthritis. Cenicriviroc is a promising CCR5 inhibitor with potentially important anti-inflammatory effects, and warrants further investigation.
Multifidelity Optimization of Hybrid Wing–Body Aircraft with Stability and Control Requirements (2018)

Methods of satisfying the stability and control (S&C) requirements for hybrid wing–body (HWB) aircraft are investigated using a multifidelity multidisciplinary optimization framework. A Reynolds-averaged Navier–Stokes solver is used for aerodynamic prediction, together with conceptual-level weight and balance models. These are coupled with a gradient-based optimizer to form a multidisciplinary optimization tool. Two HWB configurations are investigated. The first uses winglets with winglet-mounted rudders for lateral control, whereas the second uses centerbody-mounted fins with rudders. Longitudinal control is achieved with one centerbody elevator and six wing-mounted elevons. The designs are optimized for a combination of minimum/maximum takeoff weight and cruise drag. The ability of the designs to maintain lateral trim with one engine inoperative at a specified minimum control speed and to achieve a given rotational acceleration at a specified rotation speed forms the off-design S&C constraints. Additional constraints at cruise ensure trim and a required static margin. In addition to a classical HWB shape, a narrower cabin layout is also considered, which provides an improved performance. The required S&C requirements are found to be attainable using both configurations, with the fin-based control having a small performance advantage. The narrow-centerbody configuration is found to provide superior performance over the classical configuration.
AUTOMATIC NIPPLE DETECTION IN MAMMOGRAMS USING LOCAL MAXIMUM FEATURES ALONG BREAST CONTOUR (2015)

Mammogram registration is an important preprocessing technique, which helps in finding asymmetrical regions in left and right breast. However, correct nipple position is the crucial key point of mammogram registration since it is the only consistent and stable landmark upon a mammogram. To locate the nipple coordinates accurately in mammogram images, this work improves previous algorithms such as maximum height of the breast border (MHBB) and proposes a novel method consisting of local spatial-maximum mean intensity (LSMMI), local maximum zero-crossing (LMZC) based on the second-order derivative, and a combined approach dependent on LSMMI and LMZC. The proposed method is tested on 413 mammogram images from MIAS and DDSM databases. Consequently, the mean Euclidean distance (MED) between the ground truth identified by the radiologist and the detected nipple position is 0.64 cm, within 1 cm of the gold standard, for estimating the proposed method. The experimental results hence indicate that our proposed method can detect the nipple positions more accurately than other previous methods. Furthermore, the proposed select visible-nipple mammograms (SVNM) algorithm with the ability of generalization has achieved a 99% selection rate for automatic clustering of nipples in a mammography database, besides automatically detecting the breast border and nipple positions in mammograms.
Conversion of Petroleum Coke into Valuable Products using Catalytic and Non-Catalytic Oxy-Cracking Reaction (2018)

Every year millions of tons petroleum coke (petcoke) is generated as a by-product from bitumen and heavy oil upgrading due to the increasing demand in energy. Petcoke is a carbonaceous solid consisting of polycyclic aromatic hydrocarbons with low hydrogen content, derived from the processing of oil sands and oil refineries. The upgrading and treating of petcoke typically include thermal techniques such as gasification and combustion. However, several challenges limit the effectiveness of these conventional processes such as sulfur and CO2 emissions as well as high energy and costs associated with low efficiency. Therefore, finding an alternative, efficient, environmentally-friendly and cost-effective technology to treat these massive amounts of petcoke is needed. In this study, an oxy-cracking technique, which is a combination of oxidation and cracking reactions, is introduced as an alternative approach for petcoke utilization. This oxy-cracking takes place in basic aqueous media, at mild operation temperatures (170-230 oC) and pressures (500-600 psi). The oxy-cracking reaction mechanism was investigated using Quinolin-65 (Q-65) as a model molecule mimicking the residual feedstocks. Theoretical calaculations along with experimental reaction were carried out on Q-65 to explore the reaction pathways. Consequently, several operating conditions on petcoke oxy-cracking were investigated, such as temperature, oxygen pressure, reaction time, particle size and mixing rate to optimize the solubility and selectivity of oxy-cracked products. To enhance the oxy-cracking reaction conversion, an in-house prepared copper-silicate catalyst was introduced and characterized using BET, SEM, FTIR and XRD techniques. The oxy-cracking technique successfully converted the petcoke into valuable products, particularly humic acids analogs with other functional groups such as carboxylic, carbonyl, and sulfonic acids, as confirmed by FTIR, XPS and NMR analyses, in addition to minimal emission of CO2. Interestingly, based on the experimental findings, the metal contents in the obtained oxy-cracked products are significantly lower than that in the virgin petcoke. Consequently, the heating value and oxidation behaviour of the oxy-cracked products was investigated using TGA. These results showed that the oxy-cracked petcoke is easier and faster to oxidize compared to the virgin petcoke, suggesting that the oxy-cracked petcoke could be an alternative-clean fuel for power generation.
Enzyme-linked immunosorbent assay using a crude antigen extract to measure <i>Cuterebra</i>-specific immunoglobulin G in sera of cats with systemic infections (2013)

In cats, larvae of the dipteran fly, Cuterebra, sometimes cause severe disease by their migration through the tissues of the larynx, pharynx, nasal sinuses, brain, and spinal cord; such infected cats may die without the maggots ever reaching the subcutaneous tissues where they would typically mature. The current study examines the ability of an indirect enzyme-linked immunosorbent assay (ELISA) using crude Cuterebra antigen from maggots to detect parasite-specific immunoglobulin (Ig)G in cats with known (n = 42), suspected (n = 25), or no known exposure to the infection (n = 68). The probability of a given optical density (OD) predicting the infection status of a given animal was determined using logistic regression, and both 1:20 and 1:80 serum dilutions were highly predictive of the potential of a cat being infected with a larval Cuterebra. In 5 cases where 2 samples were collected 1-2 weeks apart, there was a mean OD increase in the second sample for both the 1:20 and 1:80 dilutions, but it was significant (P = 0.044) only at the 1:20 dilution. Sex of the sampled cat was not a significant contributor to the ability of the OD to predict the presence of a larva, but the age of the cat added significantly to the predictive value of the generated curves, with the only exception being with the 1:20 serum dilution with the curve being generated only using the cats known to be positive for larval presence. This ELISA should aid in ruling cuterebriasis in or out in suspect systemic and, specifically, neurologic cases and provide information on kinetics of antibody presence postexposure.
Compress-and-Forward Cooperative MIMO Relaying With Full Channel State Information (2009)

This paper addresses cooperative time division duplex (TDD) relaying in the multiple-antenna case with full channel state information (CSI), i.e., assuming perfect knowledge of all channels. The main focus of the paper is on the compress-and-forward (CF) strategy, for which an achievable rate on the Gaussian MIMO relay channel can be derived by applying distributed vector compression techniques. The processing at the CF relay consists in a conditional Karhunen-Loeve transform (CKLT) followed by a separate Wyner-Ziv (WZ) coding of each output stream at a different rate. The paper provides a simple analytical expression for the optimum WZ coding rates, and also proposes an iterative procedure to perform this optimization jointly with that of the transmit covariance matrices at the source and relay. The multiple access channel (MAC) formed by the source and relay transmitting simultaneously to the destination is considered, and it is shown that an optimal decoding order exists at least in the single-antenna case. We discuss the extension to MIMO-OFDM, as well as practical source coding implementation. The CF achievable rates are benchmarked with other upper and lower bounds on capacity. Simulation results show that CF can outperform decode-and-forward (DF) and approach capacity for realistic SNR values, which validates the performance of the proposed optimization procedure.
Class 8 Tractor Trailer Platooning: Effects, Impacts, and Improvements (2016)

This poster provides information about NREL's evaluation of the fuel savings potential of semi-automated truck platooning. Platooning involves reducing aerodynamic drag by grouping vehicles together and decreasing the distance between them through the use of electronic coupling, which allows multiple vehicles to accelerate or brake simultaneously. The U.S. Department of Energy's interest in platooning stems from the opportunity to reduce petroleum consumption. This work addresses the need for data and analysis on what aspects of operation can impact platooning savings and what can be done to maximize the savings realized.
Non-parametric, hypothesis-based analysis of microarrays for comparison of several phenotypes (2004)

By integrating inference principles within a bioinformatics setting, we introduce a two-stage approach to select candidate genes that characterize several criteria. The method is unified in its non-parametric approach to inference and description. For inference, we construct a testable hypothesis based on the criteria of interest in a high-dimensional space, while preserving the dependence among genes. Upon rejecting the null, we estimate the cardinality of a set of individual candidate genes (or gene pairs) that depict the events of interest. With this estimate, we then select individual genes (or gene pairs) based upon a two-dimensional ranking that examines relations within and between genes, among comparison groups, using singular value decomposition in combination with inner product concepts.
Specificity of binding of zona pellucida glycoproteins to sperm proacrosin and related proteins (1993)

A major regulatory site for species specificity of fertilization in mammals lies at the level of sperm binding to the zona pellucida. This implies a high degree of complementarity between gamete receptor molecules. One putative receptor molecule on spermatozoa is proacrosin/acrosin which binds to zona pellucida glycoproteins (ZPGPs) non-enzymically and with high affinity. The mechanism of recognition involves polysulphate groups in a particular stereochemical orientation and it has been suggested that this may contribute to species specificity of sperm-egg binding. In the present work this hypothesis has been tested by challenging 125I-labelled ZPGPs from pig, cow, and hamster eggs to recognize heterologous sperm proacrosins as well as a variety of sequence-related and unrelated proteins. Results show that pig and cow 125I-ZPGPs bind readily to boar, ram, and bull proacrosin but do not recognize guinea-pig proacrosin or any of the polysulphate binding proteins from rat, hamster, or mouse spermatozoa. Hamster 125I-ZPGPs also recognise boar, ram, and bull proacrosin as well as a range of unidentified proteins in pH3 extracts of hamster, rat, and mouse spermatozoa. The binding of ZPGPs to a variety of proteins not related to proacrosin is strongest to those with a high content of basic residues (i.e., pI > 8.5), although the secondary folding of the target protein is of major importance as boar proacrosin (pI 6.75) has the highest binding capacity of all proteins tested. Cross-reaction of ZPGP probes was not observed to guinea-pig proacrosin, suggesting that in this species the conformation of the protein is different to other sperm proacrosins.(ABSTRACT TRUNCATED AT 250 WORDS)
Automated detection of performance regressions using statistical process control techniques (2012)

The goal of performance regression testing is to check for performance regressions in a new version of a software system. Performance regression testing is an important phase in the software development process. Performance regression testing is very time consuming yet there is usually little time assigned for it. A typical test run would output thousands of performance counters. Testers usually have to manually inspect these counters to identify performance regressions. In this paper, we propose an approach to analyze performance counters across test runs using a statistical process control technique called control charts. We evaluate our approach using historical data of a large software team as well as an open-source software project. The results show that our approach can accurately identify performance regressions in both software systems. Feedback from practitioners is very promising due to the simplicity and ease of explanation of the results.
Are MCDA Methods Benchmarkable? A Comparative Study of TOPSIS, VIKOR, COPRAS, and PROMETHEE II Methods (2020)

Multi-Criteria Decision-Analysis (MCDA) methods are successfully applied in different fields and disciplines. However, in many studies, the problem of selecting the proper methods and parameters for the decision problems is raised. The paper undertakes an attempt to benchmark selected Multi-Criteria Decision Analysis (MCDA) methods. To achieve that, a set of feasible MCDA methods was identified. Based on reference literature guidelines, a simulation experiment was planned. The formal foundations of the authors’ approach provide a reference set of MCDA methods ( Technique for Order Preference by Similarity to Ideal Solution (TOPSIS), VlseKriterijumska Optimizacija I Kompromisno Resenje (VIKOR), Complex Proportional Assessment (COPRAS), and PROMETHEE II: Preference Ranking Organization Method for Enrichment of Evaluations) along with their similarity coefficients (Spearman correlation coefficients and WS coefficient). This allowed the generation of a set of models differentiated by the number of attributes and decision variants, as well as similarity research for the obtained rankings sets. As the authors aim to build a complex benchmarking model, additional dimensions were taken into account during the simulation experiments. The aspects of the performed analysis and benchmarking methods include various weighing methods (results obtained using entropy and standard deviation methods) and varied techniques of normalization of MCDA model input data. Comparative analyses showed the detailed influence of values of particular parameters on the final form and a similarity of the final rankings obtained by different MCDA methods.
Anion Fractionation and Reactivity at Air/Water:Methanol Interfaces. Implications for the Origin of Hofmeister Effects (2008)

Anions are selectively enriched in interfacial layers. This universal phenomenon, first identified in connection with protein precipitation 120 years ago, underlies fundamental processes. Its physical causes, however, remain conjectural. It has been speculated that the more polarizable anions should have larger affinities for air/liquid interfaces, and that their reactivities toward gaseous species would be affected by whether the liquid is capped by hydroxyl groups, as in water itself, or by hydrophobic layers of organic contaminants. These issues are particularly relevant to the composition and fate of atmospheric aerosols. Recently, we found that fractionation factors, f X (-) , of simple anions at the air/water interface increase exponentially with ion radius, a X (-) . In this paper, we report new experimental results on a set of anions that include the large PF 6 (-) and the highly polarizable IO 3 (-) species. A strict ln f X (-) proportional, variant a X (-) correlation is confirmed. Experiments performed in { x wH 2O + (1 - x w)MeOH} mixtures show that f X (-) is almost independent of x w. Furthermore, O 3(g) oxidizes I (-) at virtually identical rates on H 2O and MeOH.
Divorce, Child Custody, and Parenting Plans (2020)

The entry provides a comprehensive overview of the consequences of divorce on children. Parenting plans after marital dissolution and child custody are also discussed, and suggestions for future research are provided.
Prognostic Analysis of Early Lymphocyte Recovery in Patients with Advanced Breast Cancer Receiving High-Dose Chemotherapy with an Autologous Hematopoietic Progenitor Cell Transplant (2004)

Early lymphocyte recovery is an independent outcome predictor in metastatic breast cancer patients receiving high-dose chemotherapy and an autologous peripheral blood progenitor cell transplant. These observations suggest that immune strategies targeting minimal posttransplant residual disease may prove worthwhile.