gebhart/patrepeval huggingface dataset:
Potent analgesic and anti‐inflammatory actions of a novel thymulin‐related peptide in the rat (2002)

1. The present study examines the effect of PAT (peptide analogue of thymulin) in two rat models of inflammatory hyperalgesia induced by either i.pl. (1.25 microg in 50 microl saline) or i.p. (50 microg in 100 microl) injections of endotoxin ET. 2. Pretreatment with PAT (1, 5 or 25 microg in 100 microl saline, i.p.) decreased, in a dose dependent manner, both mechanical hyperalgesia, determined by the paw pressure (PP) test and thermal hyperalgesia determined by the hot plate (HP), the paw immersion (PI) and the tail flick (TF) tests. 3. Compared to the tripeptides K(D)PT and K(D)PV, known to antagonize interleukin (IL)-1beta or IL-1beta and PGE(2) mechanisms, PAT, at lower dosages, exerted stronger anti-hyperalgesic effects. 4. When compared with the effect of a steroidal (dexamethasone) and a non-steroidal (indomethacin) anti-inflammatory drugs (NSAID), PAT demonstrated equal analgesic actions. 5. Pretreatment with PAT, reduced significantly the increased concentration of IL-1beta, IL-6, TNF-alpha and NGF due to i.pl. injection of ET. 6. Injection of i.p. ET produced sickness behaviour characterized by hyperalgesia and fever. Pretreatment with PAT prevented the hyperalgesia and maintained the body temperature within the normal range and was accompanied by a down-regulation of the levels of pro-inflammatory cytokines and PGE(2) in the liver. 7. PAT, in all doses used, did not result in any evident changes in the physiological parameters or in the normal behaviour of the rats. 8. The anti-hyperalgesic and anti-inflammatory effects of PAT can be attributed, at least partially, to the down-regulation of pro-inflammatory mediators.
Efficient Static Well Assignment in Parallel Reservoir Simulation (2020)

Summary Load balancing poses a challenge to massively parallel reservoir simulation. Inefficient work distribution impedes scalability and leads to inefficient use of computing resources. Rather than addressing the more popular - and admittedly more important - topic of grid partitioning, this paper delves into the problem of the assignment of wells to processes. In the presented method, well activity mask is first obtained using a proxy model. Using this information, the well assignment task is translated to a bin packing problem and First Fit Decreasing algorithm is applied. Depending on the percentage of the simulation time that an average well is active, the results show between 8.2% and 73.8% improvement in terms of the number of bins. The number of bins is directly correlated with the maximum number of processes that can be assigned at most one well at a time which is beneficial in scenarios where the number of wells is greater than the number of processes assigned to the simulation run.
Overexpression of a plasma membrane protein generated broad‐spectrum immunity in soybean (2020)

Plants fight-off pathogens and pests by manifesting an array of defence responses using their innate immunity mechanisms. Here we report the identification of a novel soybean gene encoding a plasma membrane protein, transcription of which is suppressed following infection with the fungal pathogen, Fusarium virguliforme. Overexpression of the protein led to enhanced resistance against not only against F. virguliforme, but also against spider mites (Tetranychus urticae, Koch), soybean aphids (Aphis glycines, Matsumura) and soybean cyst nematode (Heterodera glycines). We, therefore, name this protein as Glycine max disease resistance 1 (GmDR1; Glyma.10g094800). The homologues of GmDR1 have been detected only in legumes, cocoa, jute and cotton. The deduced GmDR1 protein contains 73 amino acids. GmDR1 is predicted to contain an ecto- and two transmembrane domains. Transient expression of the green fluorescent protein fused GmDR1 protein in soybean leaves showed that it is a plasma membrane protein. We investigated if chitin, a pathogen-associated molecular pattern (PAMP), common to all pathogen and pests considered in this study, can significantly enhance defence pathways among the GmDR1-overexpressed transgenic soybean lines. Chitin induces marker genes of the salicylic- and jasmonic acid-mediated defence pathways, but suppresses the defence pathway regulated by ethylene. Chitin induced SA- and JA-regulated defence pathways may be one of the mechanisms involved in generating broad-spectrum resistance among the GmDR1-overexpressed transgenic soybean lines against two serious pathogens and two pests including spider mites, against which no known resistance genes have been identified in soybean and among the most other crop species.
Phase-shift and amplitude control for an active rectifier to maximize the efficiency and extracted power of a Wireless Power Transfer system (2015)

Wireless Power Transfer (WPT) is an emerging technology with a huge variety of possible applications, including wireless charging of mobile devices like smart-phones or tablet computers. Currently available systems targeting these applications achieve a relatively low efficiency and hence a limited charging capability. To overcome these drawbacks, this work proposes a concept to maximize the efficiency of a WPT system as well as to increase the amount of extracted power. The presented method is based on actively modifying the equivalent secondary-side load impedance by controlling the phase-shift of the active rectifier and its output voltage level. The proposed concept enables WPT systems to actively adjust both the resistive as well as the reactive part of the equivalent load impedance, hence increasing the system performance in terms of efficiency and extracted power. A prototyping system for mobile applications has been developed based on the Qi standard specifications. The acquired experimental results confirm that the proposed concept is able to obtain a higher system efficiency and to extract more power than state-of-the-art solutions.
Sketching reality (2008)

In this article, we introduce sketching reality , the process of converting a freehand sketch into a realistic-looking model. We apply this concept to architectural designs. As the sketch is being drawn, our system periodically interprets its 2.5D-geometry by identifying new junctions, edges, and faces, and then analyzing the extracted topology. The user can add detailed geometry and textures through sketches as well. This is possible through the use of databases that match partial sketches to models of detailed geometry and textures. The final product is a realistic texture-mapped 2.5D-model of the building. We show a variety of buildings that have been created using this system.
Rapid Volumetric OCT Image Acquisition Using Compressive Sampling (2010)

Acquiring three dimensional image volumes with techniques such as Optical Coherence Tomography (OCT) relies on reconstructing the tissue layers based on reflection of light from tissue interfaces. One B-mode scan in an image is acquired by scanning and concatenating several A-mode scans, and several contiguous slices are acquired to assemble a full 3D image volume. In this work, we demonstrate how Compressive Sampling (CS) can be used to accurately reconstruct 3D OCT images with minimal quality degradation from a subset of the original image. The full 3D image is reconstructed from sparsely sampled data by exploiting the sparsity of the image in a carefully chosen transform domain. We use several sub-sampling schemes, recover the full 3D image using CS, and show that there is negligible effect on clinically relevant morphometric measurements of the optic nerve head in the recovered image. The potential outcome of this work is a significant reduction in OCT image acquisition time, with possible extensions to speeding up acquisition in other imaging modalities such as ultrasound and MRI.
A Wideband High Gain Circularly Polarized Antenna for Satellite Applications (2019)

A single-feed wideband high gain circularly polarized (CP) stacked-antenna is proposed for INMARSAT/GNSS application. The antenna involves of a radiating ring-slotted patch with a grounded via, a slit-slotted stacked patch, an air gap, and a coaxial feeding probe. An antenna prototype at the L-band with total size of 100mm × 100mm × 21mm shows a measured 3-dB axial ratio (AR) bandwidth of 11.3% (1.50 GHz-1.68 GHz), impedance bandwidth (-10dB reflection coefficient) of 17.6% (1.45 GHz-1.73 GHz), and gain greater than 7.2 dBic across the AR bandwidth.
Investigation into flexural characteristics of a bar subjected to local heating: The effect of heat source location (2008)

The flexural motion of a bar subjected to local heating, resembling the welding process, is considered and the influence of the location of the heat source on the flexural characteristics is examined. A temperature heat source is assumed along the width of the bar to account for the local heating. Temperature-dependent mechanical properties such as elastic modulus are accommodated in the simulations. This modifies the amplitude and the frequency of the flexural wave generated in the bar. A numerical scheme using the finite element method is introduced to predict the flexural characteristics. It is found that the amplitude difference of the flexural wave owing to heating and no-heating situations varies with changing the location of the heat source. This is also true for the time period difference of the flexural waves owing to heating and no-heating situations of the bar.
Clinical Efficacy and Safety of Recombinant Canine Erythropoietin in Dogs with Anemia of Chronic Renal Failure and Dogs with Recombinant Human Erythropoietin-Induced Red Cell Aplasia (2004)

The efficacy and safety of recombinant canine erythropoietin (rcEPO) therapy was evaluated in 19 dogs with anemia of chronic renal failure (group 1) and 6 dogs with chronic renal failure and recombinant human erythropoietin (rhEPO)-induced red cell aplasia (group 2). Hematocrit (Hct) and absolute reticulocyte count (ARC) were monitored weekly for the first 8 weeks, CBC (including ARC) and serum iron profiles were evaluated monthly, and serum biochemical analyses were performed every 2 months for 6 (group 2) to 12 (group 1) months. For group 1 dogs, median Hct and ARC increased significantly during the 1st week of rcEPO treatment, and median Hct was sustained at >35% after week 5. In contrast, median Hct and ARC for group 2 did not change significantly with rcEPO treatment, even with doses greater than those used in group 1. Nevertheless, 2 (33%) of the 6 dogs in group 2 developed erythroid hyperplasia, reticulocytosis, and increases in Hct with rcEPO treatment. Although median systolic blood pressure did not change significantly in either group, 5 dogs developed systolic blood pressures > or = 180 mm Hg during the study. Appetite and energy level improved in most group 1 dogs with increases in Hct. Recombinant cEPO stimulated erythrocyte production in dogs with nonregenerative anemia secondary to chronic renal failure without causing the profound erythroid hypoplasia that can occur in rhEPO-treated dogs. Unfortunately, rcEPO was not as effective in restoring erythrocyte production in dogs that had previously developed rhEPO-induced red cell aplasia.
A Two-Gene Classifier for Predicting Response to the Farnesyltransferase Inhibitor Tipifarnib in Acute Myeloid Leukemia. (2007)

Abstract Currently there is no method available to predict response to farnesyltransferase inhibitors (FTI). We analyzed gene expression profiles from the bone marrow of patients from a phase 2 study of the FTI tipifarnib (R115777, ZARNESTRA), in older adults with previously untreated acute myeloid leukemia (AML). The RASGRP1:APTX gene expression ratio was found to predict response to tipifarnib with the greatest accuracy. This two-gene ratio was validated by quantitative PCR in the newly diagnosed AML cohort. We further demonstrated that this classifier could predict response to tipifarnib in an independent set of 54 samples from relapsed or refractory AML, with a negative predictive value and positive predictive value of 92% and 28%, respectively (odds ratio of 4.4). The classifier also predicted for improved overall survival (154 vs 56 days, p = 0.0001), which was shown to be independent of other prognostic factors including a previously described gene expression classifier predictive of prognosis. Therefore, these data indicate that a two-gene expression assay may have utility in categorizing a population of AML patients who are more likely to respond to tipifarnib.
An advanced model of a high pressure liquid dielectric switch for directed energy applications (2004)

A high power liquid dielectric switch is being developed to satisfy the requirements for future directed energy applications. A flowing, high-pressure liquid dielectric was chosen for the design of a megavolt class switch operating at 100 pps. This paper reports on the modeling efforts commensurate with the design of a full size, prototype 250-300 kV concept validation test (CVT), switch that can transfer kilojoules per pulse. The flow system required to clear the discharge bubble and byproducts is intimately tied to the dynamics of energy deposition, and bubble formation. A circuit model has been developed to predict the discharge temporal characteristics including the voltage, current, risetime, arc energy deposition profile, and time varying arc inductance, bubble formation timescales and oscillatory bubble effects. The model utilizes both the Braginskii equation and Charlie Martin's equations to calculate the energy dissipated in the arc. A comparison of the two methods is presented. An integrated model also includes the hydrodynamic equations to predict the gas bubble volume and oscillation period, which are dramatically reduced with increasing pressure. Optimization studies indicate that a 1000-2000 psi switch appears to have ideal attributes including minimal dielectric flow requirements, compact size and low weight for implementation of a kilojoule, rep-rate switch.
Gene perturbation and intervention in probabilistic Boolean networks (2002)

A library of functions written in MATLAB for simulating PBNs, constructing state-transition matrices, computing steady-state distributions, computing influences, modeling random gene perturbations, and finding optimal intervention targets, as described in this paper, is available on request from is@ieee.org.
Energy storage systems having an electrode comprising Li.sub.xS.sub.y (2016)

Improved lithium-sulfur energy storage systems can utilizes Li.sub.xS.sub.y as a component in an electrode of the system. For example, the energy storage system can include a first electrode current collector, a second electrode current collector, and an ion-permeable separator separating the first and second electrode current collectors. A second electrode is arranged between the second electrode current collector and the separator. A first electrode is arranged between the first electrode current collector and the separator and comprises a first condensed-phase fluid comprising Li.sub.xS.sub.y. The energy storage system can be arranged such that the first electrode functions as a positive or a negative electrode.
A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-κB Signaling in <i>KRAS</i> -Mutant Colon Cancer Cells (2018)

We previously demonstrated that miR-29b-3p is a hopeful miRNA-based therapy against colorectal cancer. In this study, we aimed to clarify a value of miR-29b-1-5p as a next-generation treatment, especially for <i>KRAS</i>-mutant colorectal cancer. RT-PCR assay showed that the expression of miR-29b-3p was high, and its partner strand, miR-29b-1-5p, level was only negligible in clinical colorectal cancer samples. Mimic-miR-29b-1-5p significantly inhibited proliferation of <i>KRAS</i>-mutant colorectal cancer cell lines DLD1 and SW480 and <i>KRAS</i> wild-type HT29 cells. Proliferative activity was further examined by either miR-29b-1-5p strand or its opposite complementary sequence because miR-29b-1-5p is a passenger miRNA and may have no physiologic function. We found that completely opposite complementary strand to miR-29b-1-5p, but not miR-29b-1-5p, possessed a potent antitumor effect and named this byproduct miRNA sequence "MIRTX." MIRTX directly targeted the 3'-UTR of <i>CXCR2</i> and <i>PIK3R1</i> mRNA and suppressed the NF-κB signaling pathway in <i>KRAS</i>-mutated colorectal cancer cells. MIRTX induced apoptosis in DLD1 with downregulation of antiapoptotic BCL2, BCL-xL, and MCL1 and upregulation of cleaved caspase-3 and cleaved PARP. In mouse xenograft models, systemic administration of MIRTX using a super carbonate apatite as a delivery vehicle significantly inhibited tumor growth of DLD1 and HT29 cells without any particular toxicities. In conclusion, these findings indicate that inhibition of NF-κB signaling by this novel miRNA-based therapeutic could be a promising treatment against refractory <i>KRAS</i>-mutant colorectal cancer and <i>KRAS</i> wild-type colorectal cancer. <i>Mol Cancer Ther; 17(5); 977-87. ©2018 AACR</i>.
A Rapid Room-Temperature NO<sub>2</sub> Sensor Based on Tellurium–SWNT Hybrid Nanostructures (2012)

One-dimensional nanostructure-based chemiresistive sensors have received great attention because of their compact design and excellent sensing performance, including high sensitivity, low detection limits, low power consumption, and the ability to integrate multisensor arrays. However, these sensors generally suffer from slow response and recovery times when they are operated at ambient conditions because of slow catalytic or absorption/desorption processes. The sensors overcome this obstacle by operating at high temperature, which increases the device complexity with a higher power consumption rate. In this work, we demonstrated the construction of an ultrafast NO2 sensor at ambient conditions by utilizing feather-like tellurium (Te) nanostructures functionalized on single-walled carbon nanotube networks. By tailoring the morphology and density of Te nanostructures, hybrid nanostructures show excellent response and recovery times of approximately 63 s and 7 min to 100 ppbV NO2 gas at room temperature.
Cloning of Bovine Prolactin cDNA and Evolutionary Implications of its Sequence (1981)

Prolactin, growth hormone, and chorionic somatomammotropin (placental lactogen) constitute a set of related polypeptides believed to derive from a common evolutionary ancestor protein. We have cloned and sequenced DNA complementary to the mRNA coding for bovine prolactin. This cDNA contains 702 bases corresponding to 10 amino acids in the leader peptide, all 199 amino acids of the hormone, and 75 nucleotides in the 3' untranslated region of the mRNA. Nucleotide sequence analysis of this cDNA permitted the identification of 10 amino acids in the signal peptide, plus the correction or elucidation of amino acid assignments at 16 sites where aspartic and glutamic acids had not been distinguished from their amides by amino acid sequencing. Codon usage in bovine prolactin mRNA is nonrandom, but, similarly to rat and human prolactins, it does not exhibit the strong preference for G or C in codon third positions seen in bovine, rat, and human growth hormone mRNAs. The translational termination signal in bovine prolactin in UAA, also the same as in rat and human prolactins and differing from the UAG "stop" codon used in bovine, rat, and human growth hormones and human chorionic somatomammotropin. The amino acid and mRNA nucleotide sequences of bovine, rat, and human prolactins and growth hormones were compared by several techniques based on various theories of molecular evolution. The comparison of prolactin to growth hormone is consistent in all three species, suggesting that the genes for these two hormones diverged about 350 million years ago. However, comparisons among the three prolactins or among the three growth hormones to determine the times of evolutionary divergence of the three species generated values that were inconsistent with each other and with the fossil record. Analysis of these discrepancies suggests that the genes for prolactin and growth hormone may now be evolving by different mechanisms.
Cost-efficient sub-lithographic patterning with tilted-ion implantation (TII) (2018)

A sub-lithographic patterning technique using tilted-ion implantation (TII) is discussed herein, as an approach for extending Moore's Law. Its suitability for defining patterns self-aligned to pre-existing linear and non-linear hard-mask features is demonstrated experimentally. In addition, its resolution limit (<; 10 nm) and line- edge roughness (LER) are investigated via experiments as well as Monte Carlo process simulations.
The Self-Incompatibility Phenotype in Brassica Is Altered by the Transformation of a Mutant <i>S</i> Locus Receptor Kinase (1998)

The self-incompatible (SI) Brassica napus line W1, which carries the 910 S allele, was transformed with an inactive copy of the 910 S locus receptor kinase (SRK) gene. Two transformed lines were analyzed based on their heritable ability to set self-seed. The first line was virtually completely self-compatible (SC), and reciprocal pollinations with the original W1 line demonstrated that only the stigma side of the SI phenotype was altered. An analysis of the expression of endogenous SRK-910 demonstrated that the mechanism of transgene action is via gene suppression. Furthermore, the expression of the S locus glycoprotein gene present in the 910 allele (SLG-910), SLG-A10, which is derived from a nonfunctional S allele, and an S locus-related gene were also suppressed. When the transgene was crossed into another SI line carrying the A14 S allele, it was also capable of suppressing the expression of the endogenous genes and of making this line SC. The second transgenic line studied was only partly SC. In this case as well, only the stigma phenotype was affected, although no gene suppression was detected for endogenous SRK-910 or SLG-910. In this line, the expression of the transgene most likely was causing the change in phenotype, and no effect was observed when this transgene was crossed into the other SI line. Therefore, this work reinforces the hypothesis that the SRK gene is required, but only for the stigma side of the SI phenotype, and that a single transgene can alter the SI phenotype of more than one S allele.
Hyperthermia: Electromagnetic Heating of Deep-Seated Tumors (1982)

Alternate methods for producing electromagnetic heating of deep-seated tumors are compared, with the focus on techniques which involve the use of a nonradiating electromagnetic field. A preference for sources which produce an electric field parallel to skin/fat/ muscle interfaces is expressed and an apparatus which accomplishes this is described. Experimental evidence in support of the theoretical rankdng of source types is presented. The evidence includes tests on animals and humans.
Respiratory motion correction for quantitative PET/CT using all detected events with internal-external motion correlation (2011)

The proposed INTEX method reduces respiratory motion degradation of PET tumor quantification and delineation in an effective manner. This can be used to improve the assessment of response to therapy for a known tumor by minimizing residual motion and matching the attenuation correction, without increasing image noise.