gebhart/patrepeval huggingface dataset:
Microbial combinatorics: a simplified approach for isolating insecticidal bacteria (2008)

Abstract Bacteria can control pest insects that damage food crops, vector diseases and defoliate trees. Conventionally, isolation of these bacteria has been from soil and sporadically from dead insects. A simplified approach for isolating insecticidal bacteria from soil using the target insect as the selective agent was employed in this study. Instead of isolating single strains of bacteria from soil and testing each individual strain for insect toxicity, mixtures of bacteria present in each soil sample were tested together directly for toxicity using Manduca sexta (Linnaeus) (Lepidoptera: Sphingidae) as a model insect. Thirty-five soil suspensions or bacterial suspensions of the 40 suspensions tested killed at least one M. sexta larva. All but one bacterial culture isolated from dead larvae and retested for toxicity, killed at least one M. sexta larva. Nineteen bacterial strains isolated from larvae killed in the first test, were identical to the bacteria fed to the retested larvae. Of the 19 strains isolated, 14 were identified by 16S rDNA sequencing as belonging to the Bacillus cereus group including three strains that formed crystals that were identified as B. thuringiensis. Of the three other spore-forming strains, two were identified as psychrotrophic B. weihenstephanensis and the third as Lysinibacillus fusiformis. Two others were identified as Enterococcus faecalis. This approach, microbial combinatorics, reduces the number of insects necessary for toxicity screening and associated time and resources compared to conventional methods that first isolate bacteria and then individually test for toxicity as well as a means of discovery of new pathogens using the insect as the selective agent.
Serum Protein Biomarkers of Fibrosis Aid in Risk Stratification of Future Stricturing Complications in Pediatric Crohn's Disease (2019)

ECM1 and other biomarkers of fibrosis may aid in determining the risk of uncomplicated inflammatory disease converting to B2 stricturing phenotypes in children with CD. Prospective validation studies to verify test performance and optimize clinical utilization are needed before clinical implementation.
Millimeter-wave beam-steering antenna array for 5G applications (2017)

In this paper, a modified uniplanar compact antenna array is designed at millimeter-wave (mm-wave) frequency bands for future 5G communications. The proposed antenna is composed of five mm-wave hexagonal antennas forming an array and printed on RO3003 flexible substrate. The proposed antenna covers the 24-30 GHz frequency range with a bandwidth of 6 GHz and exhibits a maximum gain of 10.7 dB. Moreover, the pattern can be steered at different desired angles by sweeping the frequency, similar to a leaky wave antenna. The simplicity of the design makes it suitable for 5G communications.
Synthesis and crystal structure of Li<sub>2</sub>NaTa<sub>7</sub>O<sub>19</sub> (1994)

The new phase Li2NaTa7O19 has been prepared by high-temperature reaction of Na2CO3, Li2CO3 and Ta2O5. Its structure has been determined and refined, from Cu-Kα1, X-ray powder diffractometer data, in space group Pbam with unit cell: a= 15.2308(6)Å, b= 23.573(1)Å, c= 3.8366(2)Å, V= 1377.5 Å3 to RF= 3.1%. The structure exhibits a layered Ta7O193– framework, containing TaO6 octahedra and TaO7 pentagonal bipyramids. The Na atoms are located in pentagonal tunnels along the c axis; the Li atom positions were not determined. High-resolution electron microscopy images confirmed the basic features of the structure. Conductivity measurements showed essentially insulating behaviour with a limited amount of ionic conductivity at high temperatures, ca. 2 × 10–7Ω–1 cm–1 at 300 °C.
Replication-Dependent Potent IFN-α Induction in Human Plasmacytoid Dendritic Cells by a Single-Stranded RNA Virus (2004)

Plasmacytoid dendritic cells sense viral ssRNA or its degradation products via TLR7/8 and CpG motifs within viral DNA via TLR9. Although these two endosomal pathways operate independently of viral replication, little is known about the detection of actively replicating viruses in plasmacytoid dendritic cell (PDC). Replication and transcription of the viral genome of ssRNA viruses as well as many DNA viruses lead to the formation of cytosolic dsRNA absent in noninfected cells. In this study, we used human respiratory syncytial virus (HRSV) encoding a fusion (F) protein for direct cytosolic entry. Both HRSV infection and cytosolic delivery of a 65-nt dsRNA led to potent IFN-alpha induction in PDC, but not in myeloid dendritic cells. Inactivation of HRSV by UV irradiation abrogated IFN-alpha induction in PDC. The comparison of two respiratory syncytial virus (RSV) constructs carrying either the HRSV or the bovine RSV F protein revealed that F-mediated cytosolic entry of RSV was absolutely required for IFN-alpha induction in PDC. HRSV-induced IFN-alpha production was independent of endosomal acidification and of protein kinase R (PKR) kinase activity, as demonstrated with chloroquine and the PKR inhibitor 2-aminopurine, respectively. In contrast, the induction of IFN-alpha by the TLR7/8 ligand R848, by the TLR9 ligand CpG-A ODN 2216, and by inactivated influenza virus (TLR7/8 dependent) was completely blocked by 2-aminopurine. IFN-alpha induction by mouse pathogenic Sendai virus was not affected in PKR- and MyD88-deficient mice, confirming that a ssRNA virus, which is able to directly enter host cells via fusion at the plasma membrane, can be detected by PDC independently of PKR, TLR7/8, and TLR9.
[Effect of acetate on the growth of Escherichia coli during aerobiosis and anaerobiosis]. (1985)

The dynamics of acetate accumulation was studied in Escherichia coli K-12 batch cultures with a substrate addition. At pH 7.0, the growth stopped at 150 mmoles of acetate per litre of the medium under the aerobic conditions or at 35 mmoles of acetate per litre of the medium under the anaerobic conditions. Experiments with extraneous addition of acetate suggest that acetic acid plays a key role in inhibiting the growth of E. coli by acid metabolites. The authors propose a hypothetical mechanism to account for the inhibiting action of acetate.
Fosinopril monotherapy: Relationship between blood pressure reduction and time of administration (1993)

The time to peak antihypertensive effect and the trough-to-peak ratio were determined in 64 Caucasian patients (19 men, 45 women) with mild to moderate hypertension [supine diastolic blood pressure (DBP) 95 to 115 mmHg]. They received placebo or fosinopril 10, 20, or 40 mg once daily for 4 weeks. The study consisted of a 4-week placebo lead-in, 4 weeks' double-blind treatment, and a 1-week placebo washout period. Vital signs were determined biweekly before dosing, and blood pressures were measured every 1 to 2 h during two 27-h periods at the beginning and end of treatment. After the first and last doses of all three regimens, the peak effect on blood pressure occurred 5 to 7 h after all three dosages. Neither peak nor trough blood pressure changes showed a clear dose-response relationship. Trough to peak ratios for the first dose, corrected for placebo effects, were 79% for fosinopril 10 mg, 48% for fosinopril 20 mg, and 74% for fosinopril 40 mg, and the trough-to-peak ratios for the last dose were 41% for fosinopril 10 mg, 32% for fosinopril 20 mg, and 44% for fosinopril 40 mg. In the 38 responders among the 48 patients receiving fosinopril (supine DBP decrease of at least 5 mmHg at 24 h postdose), trough-to-peak ratios ranged from 50 to 81%, and the range indicates that fosinopril is efficacious when administered once daily. Adverse effects were mild to moderate, and no patient discontinued treatment. Changes in the laboratory test results, electrocardiograms, or the results of physical examinations were unremarkable.(ABSTRACT TRUNCATED AT 250 WORDS)
Preferential and persistent activation of the STAT1 pathway in rheumatoid synovial fluid cells. (2001)

STAT1 and STAT3 are differentially regulated in response to IL-6 in different cell types. The continuous STAT1 activation may be of pathogenic significance in the progression and persistence of RA.
Biofuel Cells with Switchable Power Output (2009)

Abstract Biofuel cells with a switchable power output controlled by external physical or chemical signals were developed. The switchable properties of biofuel cells were achieved by modification of biocatalytic electrodes with signal‐responsive materials sensitive to various stimuli triggering reversible transition of the electrode interfaces between electrochemically active and inactive states. Electrical, magnetic and biochemical signals were used as stimuli controlling the electrode activity. Biochemical systems of various complexity mimicking Boolean logic operations AND / OR as well as multienzyme/multilogic gates networks were functionally coupled with the pH‐sensitive electrodes in the biofuel cell. This allowed switching ON and OFF the power production in the biofuel cell upon application of many different biochemical signals logically processed by the enzyme systems according to the built‐in logic ‘program’. The studied switchable biofuel cells controlled by electric, magnetic and biochemical signals exemplify novel bioelectronic devices activated by external signals on‐demand. They open a new facet in the multidisciplinary field of bioelectronics and keep a big promise for practical applications, particularly as implantable sustainable energy sources for biomedical applications. The present paper gives a short overview of various switchable/tunable biofuel cells with the power production controlled by external signals.
A Suggestion for High Power LED Package Based on LTCC (2006)

A high power package based on LTCC, multi layer ceramic-metal package, MLCMP, has been proposed. To comply with recent demands for high power LEDs, the proposed package utilized large scale via slug for heat sink slug whose cross section area is greater than ordinary LED die size. The via slug could be constructed in a single tiring process. The matching quality at the ceramic-metal interface was acceptable for reliable LED package and thermal conductivity of the sintered silver was assumed to be nearly equivalent to bulk silver. Thus, the proposed MLCMP is equivalent to existing heat sink slug type packages, where the chip is located on the metal heat sink slug and heat is efficiently transmitted to circuit board by the aid of the heat sink slug. Thermal resistance of MLCMP was evaluated numerically and experimentally. In the numerical simulation, MLCMP was compared with conventional heat slug type package and aluminum nitride based package. Thermal resistance of all the three packages is less than 10 K/W. As the cross section of the via slug increases, thermal resistance of MLCMP exceeds those of the two other packages. A transient thermal analyzer was used to measure actual thermal resistance of working MLCMP. The measured data were compared with analytic solutions. Thermal resistance contributed to MLCMP has been revealed to be less than 1.0 K/W. Considering the affordability and design flexibility, we anticipate the proposed MLCMP is not only suitable for high power LED package but also a promising solution for illumination modules.
Comparison of human and mouse DAZL/BOLL expression patterns during meiosis. (2015)

<p><b>A</b>) DAZL and BOLL show distinct spatio-temporal distributions which change during human fetal ovarian development. The timeline is depicted in stages of meiosis in the human due to the wide range of germ cell developmental stages present at any specific week of gestation. DAZL is expressed before and at meiosis initiation but down-regulated afterwards; BOLL is transiently expressed at later stages of meiosis with minimal overlap with DAZL. DAZL is re-expressed in oocytes within primordial follicles. <b>B</b>) Expression of Dazl and Boll during meiosis in the feto-neonatal mouse ovary. Dazl is expressed before and throughout meiosis, whereas Boll is detected only transiently expressed around E15.5.</p>
Voltage monitor circuit for ESD diagnosis (2011)

A newly designed on-chip voltage monitor circuit (VM) is capable of recording for subsequent readout the peak voltage reached at internal nodes during ESD events. Real-time voltage probing techniques during wafer-level CDM are verified using VMs; guidelines are discussed for reducing the impact of probing on current flow.
Suppression of cardiac alternans by alternating-period-feedback stimulations (2013)

Alternans response, comprising a sequence of alternating long and short action potential durations in heart tissue, seen during rapid periodic pacing can lead to conduction block resulting in potentially fatal cardiac failure. A method of pacing with feedback control is proposed to reduce the alternans and therefore the probability of subsequent cardiac failure. The reduction is achieved by feedback control using small perturbations of constant magnitude to the original, alternans-generating pacing period T, viz., using sequences of two alternating periods of T+ΔT and T-ΔT, with ΔT<<T. Such a control scheme for alternans suppression is demonstrated experimentally in isolated whole heart experiments. This alternans suppression scheme is further confirmed and investigated in detail by simulations of ion-channel-based cardiac models both for a single cell and in one-dimensional spatially extended systems. The mechanism of the success of our method can be understood in terms of dynamics in phase space, viz., as the state of activity of the cell being confined within a narrow volume of phase space for the duration of control, resulting in extremely diminished variation in successive action potential durations. Our method is much more robust to noise than previous alternans reduction techniques based on fixed point stabilization and should thus be more efficient in terms of experimental implementation, which has implications for clinical treatment for arrhythmia.
HSP27 BLOCKADE SELECTIVELY INHIBITS GROWTH OF PTEN DEFICIENT TUMORS BY REGULATING PEA-15 ACTIVITY IN AN AKT DEPENDENT MANNER (2009)

You have accessJournal of Urology1 Apr 2009HSP27 BLOCKADE SELECTIVELY INHIBITS GROWTH OF PTEN DEFICIENT TUMORS BY REGULATING PEA-15 ACTIVITY IN AN AKT DEPENDENT MANNER Norihiro Hayashi, Eliana Beraldi, Jame Peacock, Amina Zoubeidi, Toshihide Kuruma, Shin Egawa, Christopher Ong, and Martin E Gleave Norihiro HayashiNorihiro Hayashi More articles by this author , Eliana BeraldiEliana Beraldi More articles by this author , Jame PeacockJame Peacock More articles by this author , Amina ZoubeidiAmina Zoubeidi More articles by this author , Toshihide KurumaToshihide Kuruma More articles by this author , Shin EgawaShin Egawa More articles by this author , Christopher OngChristopher Ong More articles by this author , and Martin E GleaveMartin E Gleave More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)61450-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "HSP27 BLOCKADE SELECTIVELY INHIBITS GROWTH OF PTEN DEFICIENT TUMORS BY REGULATING PEA-15 ACTIVITY IN AN AKT DEPENDENT MANNER." The Journal of Urology, 181(4S), pp. 513–514 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 513-514 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetrics Author Information Norihiro Hayashi More articles by this author Eliana Beraldi More articles by this author Jame Peacock More articles by this author Amina Zoubeidi More articles by this author Toshihide Kuruma More articles by this author Shin Egawa More articles by this author Christopher Ong More articles by this author Martin E Gleave More articles by this author Expand All Advertisement PDF downloadLoading ...
Development of a robotic 3D bioprinting and microfluidic pumping system for tissue and organ engineering (2019)

The technology of 3D bioprinting has gained significant interest in biomedical engineering, regenerative medicine, and the pharmaceutical industry. Providing a new scope in tissue and organ printing, 3D bioprinters are becoming commercialized for biological processes. However, the current technology is costly, ranging from USD$9,000-$30,000 and is limited to customized extrusion methods. Multiple microfluidic pump systems for bioink extrusion are commercially available at USD$30,000. Additionally, the use of Cartesian systems for 3D printing restricts the user to three axes of movement and makes multi-material modeling a challenge. Consequently, it was proposed to design a cost effective robotic 3D bioprinting system, compatible with peptide bioinks which were developed at KAUST Laboratory for Nanomedicine. The components of the system included a programmable robotic arm, an extruder for bioprinting, and multiple microfluidic pumps. The extruder was designed using a coaxial nozzle made of three inlets and one outlet. The programmable microfluidic pumps transported the peptide bioink, phosphate buffer saline (PBS) and human skin fibroblast cells (in cell culture media solution) through the nozzle to extrude a peptide nanogel thread. Model cell structures were printed and monitored for a period of two weeks and subsequently found to be alive and healthy. The system was kept well under a budget of USD$3,500. Future modifications of the current system will include adding a custom bioprinting arm to allow multi-material printing which can fully integrate and synchronize between the pumps and the robotic arm. This system will allow the production of a more advanced robotic arm-based 3D bioprinting system in the future.
Differentiation-Inducing Activity of Lupeol, a Lupane-Type Triterpene from Chinese Dandelion Root (Hokouei-kon), on a Mouse Melanoma Cell Line. (2000)

We examined the differentiation-inducing effects of extracts of 49 wild plants, 25 types of seaweed and 26 mushrooms in Akita on the human leukemia cell line HL60 and a B16 mouse melanoma-derived sub-clone with high differentiation capability (B16 2F2). Differentiation inducers of HL60 cells such as retinoic acid, showed no effects on the differentiation of B16 2F2 cells. Furthermore, chemical compounds known to be inducers of B16 cells, did not induce differentiation of HL60 cells. Screening tests showed that the differentiation of HL60 cells was induced by extracts of 28 wild plants, 10 types of seaweed and 2 mushrooms, and melanogenesis of B16 2F2 cells was increased by extracts of 21 wild plants, 8 types of seaweed and 7 mushrooms. All of the alcoholic extracts of plants belonging to the subfamily Cichorioideae of the family Compositae caused cell differentiation of the melanoma cell line. The extracts of Chinese dandelion root, also inhibited cell growth and induced melanogenesis of B16 2F2 cells. We isolated the active compound from ethanol extracts of the crude drug. Chemical and physical data for the active compound were identical with those for lupeol, a lupane-type triterpene.
Development of perceptual context-sensitivity in unsupervised neural networks: parsing, grouping, and segmentation (2003)

A simple self-organizing neural network model, called an EXIN network, that learns to process sensory information in a context-sensitive manner is described. Exposure to a perceptual environment during a developmental period configures the network to perform appropriate organization of sensory data. An anti-Hebbian learning rule causes some lateral inhibitory connection of sensory data. An anti-Hebbian learning rule causes some lateral inhibitory connection weights to weaken, thereby letting multiple neurons become simultaneously active. The rule lets other inhibitory weights remain strong; these enforce specific simultaneous contextual consistency constraints on allowable combinations of activations. EXIN networks perform near-optimal parallel parsing of multiple superimposed patterns, by simultaneous distributed activation multiple neurons. EXIN networks implement a form of credit assignment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Polymer Free Volume and Its Connection to the Glass Transition (2016)

In this Perspective we summarize the most widely used definitions of free volume and illustrate the differences between them, including the important distinction between total free volume and excess free volume. We discuss the implications when alternative estimates for free volume are inserted into relationships that connect experimentally measured properties (e.g., the viscosity) to free volume, such as those proposed by Doolittle, Fox and Flory, Simha and Boyer, Cohen and Turnbull, and Williams, Landel, and Ferry. Turning to the results of our own locally correlated lattice (LCL) model, we demonstrate, by analyzing data for a set of over 50 polymers, that our calculations for total percent free volume not only lead to a predictive relationship with experimental glass transition temperatures but also allow us to place the different definitions of free volume within a physical picture of what the proposed contributions represent. We find that melts go glassy upon reaching a “boundary” of minimum (total) percent free volume that depends roughly linearly on temperature. We interpret this boundary as being close to the T-dependent free volume associated with solid-like segmental vibrational motions. Since the LCL model is a first-principles thermodynamic theory, we are also able to link our free volume predictions to similar patterns that we find in the predicted entropy per theoretical segment. Our results are consistent with a picture wherein the difference in entropy between the melt (liquid) state and corresponding solid state vanishes as the glass transition is approached. This leads us to a new connection with the work of Adams and Gibbs, whose model reflects a similar vanishing of the configurational entropy. We conclude by discussing why the approach to the glassy state is best viewed as being controlled via the linked contributions of free volume and temperature.
From chemical systems to systems chemistry: Patterns in space and time (2015)

We present a brief, idiosyncratic overview of the past quarter century of progress in nonlinear chemical dynamics and discuss what we view as the most exciting recent developments and some challenges and likely areas of progress in the next 25 years.
Williams, Charles H. (1896–1978) (2018)

In a career spanning 1910–1951, Charles H. Williams was a pioneering educator, author, choreographer, and athletic director at the Hampton Institute in Virginia, an all-Black school that focused on the vocational education of young people. His interest in dance came from his work developing new ways to connect physical education, creative movement, and recreation with self-improvement and moral development. Echoing the New Negro philosophy of the Harlem Renaissance and paralleling the efforts of Edna Guy, Hemsley Winfield, and Asadata Dafora, he believed that dance served the important purpose of connecting African Americans to their heritage. Inspired in part by his association with modern dance pioneer Ted Shawn, he founded the Hampton Institute Creative Dance Group in 1934. At a time when higher education was largely segregated, this non-professional African-American concert dance group toured nationally and, in so doing, created a place for modern dance within historically Black colleges and an audience for modern dance among the Black middle-class.