gebhart/patrepeval huggingface dataset:
Linoleic acid therapy in severe experimental allergic encephalomyelitis in the guinea-pig: suppression by continuous treatment. (1980)

The effect of oral linoleic acid (LA) treatment on experimental allergic encephalomyelitis (EAE) in guinea-pigs in three trials of differing disease intensity has been investigated. The efficacy of LA treatment was linked to the severity of the disease being suppressed. The trial with the greatest disease severity showed no beneficial effect. The other two trials with less severe disease showed a marked therapeutic response to LA, but only when treatment was started before immunization and given continuously. This was apparent in both clinical and histopathological responses. These results support an immunoregulatory mechanism for LA treatment in EAE and by analogy in multiple sclerosis.
Lipolanthionine Peptides Act as Inhibitors of TLR2-Mediated IL-8 Secretion. Synthesis and Structure−Activity Relationships (2006)

Lipoproteins from gram-positive and -negative bacteria, mycoplasma, and shorter synthetic lipopeptide analogues activate cells of the innate immune system via the Toll-like receptor TLR2/TLR1 or TLR2/TLR6 heterodimers. For this reason, these compounds constitute highly active adjuvants for vaccines either admixed or covalently linked. The lanthionine scaffold has structural similarity with the S-(2,3-dihydroxypropyl)cysteine core structure of the lipopeptides. Therefore, lanthionine-based lipopeptide amides were synthesized and probed for activity as potential TLR2 agonists or antagonists. A collection of analytically defined lipolanthionine peptide amides exhibited an inhibitory effect of the TLR2-mediated IL-8 secretion when applied in high molar excess to the agonistic synthetic lipopeptide Pam3Cys-Ser-(Lys)4-OH. Structure-activity relationships revealed the influence of the chirality of the two alpha-carbon atoms, the chain lengths of the attached fatty acids and fatty amines, and the oxidation level of the sulfur atom on the inhibitory activity of the lipolanthionine peptide amides.
Dual Polarized Patch Antenna Fed by Meandering Probes (2007)

A dual polarized patch antenna fed by meandering probes is presented. The antenna achieves an impedance bandwidth (SWR < 2) of 26% at each input port. By locating the meandering probes appropriately, the antenna has isolation more than 25 dB, which can be further enhanced to more than 30 dB by surrounding the antenna with vertical metallic walls. The gain of the antenna is about 10 dBi across the operating bandwidth.
Multiparty Homomorphic Encryption: from Theory to Practice (2023)

Multiparty homomorphic encryption (MHE) enables a group of parties to encrypt data in a way that (i) enables the evaluation of functions directly over its ciphertexts and (ii) enforces a joint cryptographic access-control over the underlying data. By extending traditional (single-party) homomorphic encryption (HE), MHE schemes support the design and deployment of highly efficient protocols for secure multiparty computation (MPC). MPC protocols based on MHE have highly desirable properties: They generally require less communication than traditional MPC techniques and have a fully public transcript. Hence, most of their execution-related costs can be outsourced to an untrusted external party (such as a cloud server). Although promising in theory, MHE-based MPC solutions have not yet been implemented in any of the 30+ existing MPC frameworks, thus revealing a gap between theory and practice. This dissertation summarizes our work toward closing this gap, by proposing contributions to both sides. On the theoretical side, we propose two MHE constructions that extend the new generation of HE schemes to the multiparty setting. Our first construction is an N-out-of-N-threshold MHE scheme that revisits the seminal lattice-based MHE construction by Asharov et al. (EUROCRYPT'12). Notably, we improve the efficiency of its setup phase, and we generalize its decryption procedure into a generalized key-switching operation that further enables re-encryption, conversion to secret-shares, and the interactive bootstrapping of its ciphertexts. Our second construction extends the first with fault-tolerance capabilities. This extension provides a T-out-of-N-threshold MHE scheme that stands as a compact and efficient alternative to the threshold scheme of Boneh et al. (CRYPTO`18), when synchronous communication can be assumed. On the practical side, we propose the Lattigo library and the Helium system. Lattigo is an open-source Go package that implements the state-of-the-art HE schemes, along with their multiparty extensions. It is also the first maintained library to implement the bootstrapping procedure for approximate homomorphic encryption. Helium builds on top of Lattigo and provides the first end-to-end open-source implementation of an MHE-based MPC protocol. We exploit the theoretical properties of this protocol to propose a helper-assisted setting, where the parties delegate most of the protocol execution cost to an honest-but-curious third party (e.g., a cloud service). As a result, Helium is also the first open-source system to support MPC with sub-linear cost for the parties, without assuming non-collusion between the multiple delegate nodes.
Synthesis and structural characterization of some nitrosyl complexes of iron, cobalt, and nickel with poly(tertiary phosphines and arsines) (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structural characterization of some nitrosyl complexes of iron, cobalt, and nickel with poly(tertiary phosphines and arsines)M. Di Vaira, C. A. Ghilardi, and L. SacconiCite this: Inorg. Chem. 1976, 15, 7, 1555–1561Publication Date (Print):July 1, 1976Publication History Published online1 May 2002Published inissue 1 July 1976https://pubs.acs.org/doi/10.1021/ic50161a018https://doi.org/10.1021/ic50161a018research-articleACS PublicationsRequest reuse permissionsArticle Views598Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
MIMO Transceiver Design Based on a Modified Geometric Mean Decomposition (2007)

We present a MIMO joint transceiver design that can run at 350 MHz on a Xilinx Virtex-4 xc4vlx200ffl513-12 FPGA. The implementation is an 8 times 8 MIMO transceiver with a 16-QAM symbol constellation. This system can provide data throughput of 11.2 Gbps. The design is based on a modified geometric mean decomposition (GMD) for a flat fading MIMO channel using VBLAST MIMO detection. The design flow uses Matlab Simulink as the model builder followed by the Xilinx System Generator to transform the Simulink model into a VHDL description which can be synthesized and mapped onto the FPGA device. Speed and area results are given for the synthesized designs.
Alea 2: job scheduling simulator (2010)

This work describes the Grid and cluster scheduling simulator Alea 2 designed for study, testing and evaluation of various job scheduling techniques. This event-based simulator is able to deal with common problems related to the job scheduling like the heterogeneity of jobs, resources, and the dynam
Neural Progenitor Cells <i>Rptor</i> Ablation Impairs Development but Benefits to Seizure‐Induced Behavioral Abnormalities (2016)

Loss of the Rptor gene in mice neural progenitor cells affects normal development in young age and may contribute to alleviate KA seizure-induced behavioral abnormalities, suggesting that raptor protein plays an important role in seizure comorbidities.
Political Advertising and Election Results* (2018)

We study the persuasive effects of political advertising. Our empirical strategy exploits FCC regulations that result in plausibly exogenous variation in the number of impressions across the borders of neighboring counties. Applying this approach to detailed data on television advertisement broadcasts and viewership patterns during the 2004–12 presidential campaigns, our results indicate that total political advertising has almost no impact on aggregate turnout. By contrast, we find a positive and economically meaningful effect of advertising on candidates’ vote shares. Taken at face value, our estimates imply that a one standard deviation increase in the partisan difference in advertising raises the partisan difference in vote shares by about 0.5 percentage points. Evidence from a regression discontinuity design suggests that advertising affects election results by altering the partisan composition of the electorate.
Deterministic regulation of hematopoietic stem cell self-renewal and differentiation (2002)

Most current theories assume that self-renewal and differentiation of hematolymphoid stem cells (HSCs) is randomly regulated by intrinsic and environmental influences. A direct corollary of these tenets is that self-renewal will continuously generate functionally heterogeneous daughter HSCs. Decisions about self-renewal versus commitment are made by individual, single HSCs and, thus, require examination on the clonal level. We followed the behavior of individual, clonally derived HSCs through long-term, serial repopulation experiments. These studies showed that daughter HSCs derived from individual clones were remarkably similar to each other in the extent and kinetics of repopulation. Moreover, daughter HSCs within a clone showed equivalent contributions to the myeloid or lymphoid lineages. Lineage contribution could be followed because of the discovery of a new subset of HSCs that gave rise stably to skewed ratios of myeloid and lymphoid cells. Overall, the data argue that self-renewal does not contribute to the heterogeneity of the adult HSC compartment. Rather, all HSCs in a clone follow a predetermined fate, consistent with the generation-age hypothesis. By extension, this suggests that the self-renewal and differentiation behavior of HSCs in adult bone marrow is more predetermined than previously thought.
A Weather-Based Hybrid Method for 1-Day Ahead Hourly Forecasting of PV Power Output (2014)

To improve real-time control performance and reduce possible negative impacts of photovoltaic (PV) systems, an accurate forecasting of PV output is required, which is an important function in the operation of an energy management system (EMS) for distributed energy resources. In this paper, a weather-based hybrid method for 1-day ahead hourly forecasting of PV power output is presented. The proposed approach comprises classification, training, and forecasting stages. In the classification stage, the self-organizing map (SOM) and learning vector quantization (LVQ) networks are used to classify the collected historical data of PV power output. The training stage employs the support vector regression (SVR) to train the input/output data sets for temperature, probability of precipitation, and solar irradiance of defined similar hours. In the forecasting stage, the fuzzy inference method is used to select an adequate trained model for accurate forecast, according to the weather information collected from Taiwan Central Weather Bureau (TCWB). The proposed approach is applied to a practical PV power generation system. Numerical results show that the proposed approach achieves better prediction accuracy than the simple SVR and traditional ANN methods.
Loss modeling of inductive components employed in power electronic systems (2011)

Loss models of inductive components are thoroughly investigated, thereby all different aspects of loss modeling are considered. The impact of peak-to-peak flux density ΔB, frequency f, DC premagnetization H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DC</sub> , temperature T, core shape, minor and major loops, flux waveform, and material on core loss calculation are considered. In order to calculate winding losses, formulas for round conductors and litz wires, each including skin- and proximity effects (including the influence of an air-gap fringing field) are included. A high level of accuracy is achieved by combining the best state-of-the-art approaches and by embedding newly-developed approaches into a novel loss calculation framework. The loss models are verified by FEM simulations and experimental measurements.
Structure and organization of four clustered genes that encode bombyxin, an insulin-related brain secretory peptide of the silkmoth Bombyx mori. (1989)

Four genes encoding bombyxin have been located in a 14-kilobase Bombyx genomic DNA segment. All of these genes encode preprobombyxin, the precursor molecule for bombyxin, with the domain organization of signal peptide/B chain/C peptide/A chain. Bombyxins are classified as family A or B according to their sequence homology. Two genes, each belonging to a different family, are closely apposed to form a pair with opposite orientation, presumably forming a regulatory unit for transcription. Genomic Southern blot hybridization suggested that there are many such gene pairs in the Bombyx genome. Differences between bombyxin genes and vertebrate insulin-family genes indicate that different mechanisms operate in the evolution of invertebrate and vertebrate insulin-family genes.
Active Object Perceiver: Recognition-Guided Policy Learning for Object Searching on Mobile Robots (2018)

We study the problem of learning a navigation policy for a robot to actively search for an object of interest in an indoor environment solely from its visual inputs. While scene-driven visual navigation has been widely studied, prior efforts on learning navigation policies for robots to find objects are limited. The problem is often more challenging than target scene finding as the target objects can be very small in the view and can be in an arbitrary pose. We approach the problem from an active perceiver perspective, and propose a novel framework that integrates a deep neural network based object recognition module and a deep reinforcement learning based action prediction mechanism. To validate our method, we conduct experiments on both a simulation dataset (AI2-THOR)and a real-world environment with a physical robot. We further propose a new decaying reward function to learn the control policy specific to the object searching task. Experimental results validate the efficacy of our method, which outperforms competing methods in both average trajectory length and success rate.
Chapter 9. (2007)

Abstract Many counselors, psychologists, and social workers assist clients to take psychotropic drugs but recoil from helping clients to rethink drug use or stop taking drugs. They might fear resisting the prevailing ideology, violating “standards of care,” or contradicting physicians' advice. This article discusses withdrawal emergent reactions from prescribed psychotropic drugs and proposes a rational, person-centered approach to help adults stop taking medication. It considers assessment, collaboration with physicians and pharmacists, the client's fear of withdrawal, the importance of gradual taper, and the monitoring of withdrawal emergent reactions. For practitioners who do not personally endorse drug use, it suggests guidelines for adhering to the best standards of care and consent. It also discusses legal and ethical issues related to therapists' concerns and clients' rights. Professionals' and consumers' roles vis-à-vis medication are changing, and a large evidence base documents the risks of medications. In this context, helping clients to withdraw from medications is a corollary to ethical and legal duties to inform clients of the availability and benefits of drugs, and its limits should be framed only by the constraints of practitioner competence and informed consent.
Selecting the optimal focus measure for autofocusing and depth-from-focus (1998)

A method is described for selecting the optimal focus measure with respect to gray-level noise from a given set of focus measures in passive autofocusing and depth-from-focus applications. The method is based on two new metrics that have been defined for estimating the noise-sensitivity of different focus measures. The first metric-the autofocusing uncertainty measure (AUM)-is useful in understanding the relation between gray-level noise and the resulting error in lens position for autofocusing. The second metric-autofocusing root-mean-square error (ARMS error)-is an improved metric closely related to AUM. AUM and ARMS error metrics are based on a theoretical noise sensitivity analysis of focus measures, and they are related by a monotonic expression. The theoretical results are validated by actual and simulation experiments. For a given camera, the optimally accurate focus measure may change from one object to the other depending on their focused images. Therefore, selecting the optimal focus measure from a given set involves computing all focus measures in the set.
Tribofilms Produced by Supply of Fine Metal Particles in Vacuum (2011)

This study demonstrates wear-protective tribofilms produced by an artificial supply of fine metal particles onto rubbing steel surfaces in vacuum. The supplied metal particles were Ag, Bi, Cu, Ni, Ti, and Fe, with the diameters of the particles ranging from 20 nm to 45 μm. The influence of the metal type of the supplied particles on the behavior of tribofilm formation as well as wear of the tribofilms were investigated. When Bi or Ti particles were supplied, the rubbed surfaces were almost entirely covered with the tribofilm. The thickness of the tribofilm produced by supplying Bi particles was 5 ∼ 8 μm. The tribofilms formed by supplying Ag, Bi or Cu particles showed initial low wear in wear tests, and the sliding distance of initial low wear was longer for the tribofilms formed by supplying finer particles. The tribofilms produced by supplying Bi (1.5 μm) particles showed the longest sliding distance of initial low wear.
ITU Regulations for Ka-band Satellite Networks (2012)

This paper gives an overview of the ITU regulations that apply to Ka-band satellite networks that operate in the geostationary satellite orbit (GSO) or a non-geostationary satellite orbit (non-GSO). In the last 5 years many satellite operators have launched or are planning to launch so-called High Throughput Satellites (HTS) operating in the Ka-band. Characteristics and examples of HTS will be given. Most HTS typically file for 3.5 GHz bandwidth in the following Ka-bands: 27.5 – 31 GHz (uplink) 17.7 – 21.2 GHz (downlink) These bands are subject to several regulatory provisions which restrict the bandwidth available. Using a simplified view of the Ka-band portion of the Table of Frequency Allocations the paper will explain the ITU regulations as they apply in each of the cases: • Bands identified for High-Density FSS (HDFSS) • Bands used by many administrations for FS including LMDS • Bands where GSO and non-GSO satellite networks have equal rights • Bands where equivalent pfd (epfd) applies • Military bands Some WRC-12 results are also reviewed including new BSS Ka-band allocations in the downlink band 21.4 – 22 GHz, clarification of the concept of “bringing into use” and what the Radio Regulations Board considers to be “reliable” information in case of a dispute.
Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice (2019)

Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release of self-dsDNA in mice. This triggers the DNA sensor cGAS (cyclic GMP-AMP synthase) and stimulator of interferon genes (STING), driving type I interferon (IFN I) dependent lung inflammation, which are attenuated in cGAS, STING or type I interferon receptor (IFNAR) deficient mice. Therefore, we demonstrate a critical role of self-dsDNA release and of the cGAS-STING-type I interferon pathway upon cigarette smoke-induced damage, which may lead to therapeutic targets in COPD.
Intracellular Context Affects Levels of a Chemically Dependent Destabilizing Domain (2012)

The ability to regulate protein levels in live cells is crucial to understanding protein function. In the interest of advancing the tool set for protein perturbation, we developed a protein destabilizing domain (DD) that can confer its instability to a fused protein of interest. This destabilization and consequent degradation can be rescued in a reversible and dose-dependent manner with the addition of a small molecule that is specific for the DD, Shield-1. Proteins encounter different local protein quality control (QC) machinery when targeted to cellular compartments such as the mitochondrial matrix or endoplasmic reticulum (ER). These varied environments could have profound effects on the levels and regulation of the cytoplasmically derived DD. Here we show that DD fusions in the cytoplasm or nucleus can be efficiently degraded in mammalian cells; however, targeting fusions to the mitochondrial matrix or ER lumen leads to accumulation even in the absence of Shield-1. Additionally, we characterize the behavior of the DD with perturbants that modulate protein production, degradation, and local protein QC machinery. Chemical induction of the unfolded protein response in the ER results in decreased levels of an ER-targeted DD indicating the sensitivity of the DD to the degradation environment. These data reinforce that DD is an effective tool for protein perturbation, show that the local QC machinery affects levels of the DD, and suggest that the DD may be a useful probe for monitoring protein quality control machinery.
DAWG: A Defense Against Cache Timing Attacks in Speculative Execution Processors (2018)

Software side channel attacks have become a serious concern with the recent rash of attacks on speculative processor architectures. Most attacks that have been demonstrated exploit the cache tag state as their exfiltration channel. While many existing defense mechanisms that can be implemented solely in software have been proposed, these mechanisms appear to patch specific attacks, and can be circumvented. In this paper, we propose minimal modifications to hardware to defend against a broad class of attacks, including those based on speculation, with the goal of eliminating the entire attack surface associated with the cache state covert channel. We propose DAWG, Dynamically Allocated Way Guard, a generic mechanism for secure way partitioning of set associative structures including memory caches. DAWG endows a set associative structure with a notion of protection domains to provide strong isolation. When applied to a cache, unlike existing quality of service mechanisms such as Intel's Cache Allocation Technology (CAT), DAWG fully isolates hits, misses, and metadata updates across protection domains. We describe how DAWG can be implemented on a processor with minimal modifications to modern operating systems. We describe a non-interference property that is orthogonal to speculative execution and therefore argue that existing attacks such as Spectre Variant 1 and 2 will not work on a system equipped with DAWG. Finally, we evaluate the performance impact of DAWG on the cache subsystem.