gebhart/patrepeval huggingface dataset:
Neuroprotective Effect of Estradiol-Loaded Poly(lactic-co-glycolic acid) Nanoparticles on Glutamate-Induced Excitotoxic Neuronal Death (2014)

Different concentrations of estradiol (E2)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (E2-PLGA-NPs) were synthesized using the emulsion-diffusion method. Transmission electron microscopy results showed that the average particle size of E2-PLGA-NPs was 98 ± 1.9 nm when stabilized with polyvinyl alcohol and 103 ± 4.9 nm when stabilized with Tween-80. Fourier transform-infrared spectroscopy with diamond attenuated total reflectance was used to identify the presence or absence of E2 molecules in PLGA nanocapsules. Cell proliferation was assessed after treating SH-SY5Y neuroblastoma cells with 1 nM-1 μM of E2 and E2-PLGA-NPs. The neuroprotective efficacy against glutamate-induced excitotoxicity was also investigated in SH-SY5Y neuroblastoma cells. Neuroprotection was greater in E2-PLGA-NP-treated cells than in cells treated with the same concentration of E2. Furthermore, E2- and E2-PLGA-NP-treated cells expressed more p-ERK1/2 and p-CREB than cells treated with glutamate only. Moreover, the expression of p-ERK1/2 was higher than that of p-CREB. In this study, p-ERK1/2 had a greater influence on the neuroprotective effect of E2 and E2-PLGA-NPs than p-CREB.
Synthesis of novel 3-(alkylthio)-2-halopyridines and related derivatives (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of novel 3-(alkylthio)-2-halopyridines and related derivativesGerald S. Ponticello, Richard D. Hartman, William C. Lumma Jr., and John J. BaldwinCite this: J. Org. Chem. 1979, 44, 17, 3080–3082Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/jo01331a026https://doi.org/10.1021/jo01331a026research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Magnetostatic interactions on a square lattice (2008)

The metastable zero field magnetic states of elongated Permalloy islands on square lattices of different geometries are investigated by means of magnetic force microscopy and numerical calculations. Keeping the island shape $L∕w=10$ fixed while varying the interparticle distances $a$, it is demonstrated that the relative frequencies of observed magnetic configuration at remanence strongly depend on the packing density of an array and the magnetic history (i.e., in which direction the array has been saturated before measurement). From 16 possible arrangements, only two are experimentally observed. For small $L∕a$, a mixture of configurations, i.e., a spin ice, is found in agreement with previous studies, while for large $L∕a$, an onion state unexpectedly prevails independent of the direction of the previously applied field. The results are discussed within the framework of potential theory and general stray field interaction. The relative frequencies of metastable states as well as the absence of the true ground state are in good agreement with theory.
Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments (2021)

Long COVID or post-COVID-19 syndrome first gained widespread recognition among social support groups and later in scientific and medical communities. This illness is poorly understood as it affects COVID-19 survivors at all levels of disease severity, even younger adults, children, and those not hospitalized. While the precise definition of long COVID may be lacking, the most common symptoms reported in many studies are fatigue and dyspnoea that last for months after acute COVID-19. Other persistent symptoms may include cognitive and mental impairments, chest and joint pains, palpitations, myalgia, smell and taste dysfunctions, cough, headache, and gastrointestinal and cardiac issues. Presently, there is limited literature discussing the possible pathophysiology, risk factors, and treatments in long COVID, which the current review aims to address. In brief, long COVID may be driven by long-term tissue damage (e.g. lung, brain, and heart) and pathological inflammation (e.g. from viral persistence, immune dysregulation, and autoimmunity). The associated risk factors may include female sex, more than five early symptoms, early dyspnoea, prior psychiatric disorders, and specific biomarkers (e.g. D-dimer, CRP, and lymphocyte count), although more research is required to substantiate such risk factors. While preliminary evidence suggests that personalized rehabilitation training may help certain long COVID cases, therapeutic drugs repurposed from other similar conditions, such as myalgic encephalomyelitis or chronic fatigue syndrome, postural orthostatic tachycardia syndrome, and mast cell activation syndrome, also hold potential. In sum, this review hopes to provide the current understanding of what is known about long COVID.
Optimization-Based Artificial Bee Colony Algorithm for Data Collection in Large-Scale Mobile Wireless Sensor Networks (2016)

Data collection is a fundamental operation in various mobile wireless sensor networks (MWSN) applications. The energy of nodes around the Sink can be untimely depleted owing to the fact that sensor nodes must transmit vast amounts of data, readily forming a bottleneck in energy consumption; mobile wireless sensor networks have been designed to address this issue. In this study, we focused on a large-scale and intensive MWSN which allows a certain amount of data latency by investigating mobile Sink balance from three aspects: data collection maximization, mobile path length minimization, and network reliability optimization. We also derived a corresponding formula to represent the MWSN and proved that it represents an NP-hard problem. Traditional data collection methods only focus on increasing the amount data collection or reducing the overall network energy consumption, which is why we designed the proposed heuristic algorithm to jointly consider cluster head selection, the routing path from ordinary nodes to the cluster head node, and mobile Sink path planning optimization. The proposed data collection algorithm for mobile Sinks is, in effect, based on artificial bee colony. Simulation results show that, in comparison with other algorithms, the proposed algorithm can effectively reduce data transmission, save energy, improve network data collection efficiency and reliability, and extend the network lifetime.
Modeling Ad Hoc Networks (2005)

This chapter contains sections titled: The Wireless Channel The Communication Graph Modeling Energy Consumption Mobility Models Asymptotic Notation
Changes produced in the urothelium by traditional and newer therapeutic procedures for bladder cancer (2002)

A handful of traditional and newer therapeutic procedures, such as chemotherapy, immunotherapy, radiotherapy, photodynamic and laser treatment, and gene therapy, are used to treat epithelial malignancies of bladder origin. These treatment modalities, used either intravesically or systemically, produce morphological changes in the urothelial mucosa that can be mistaken for carcinoma. The pathologist must be able to separate toxic and drug related alterations from tumour related changes. The clinical history is usually invaluable in this assessment.
Cephalometric analysis for diagnosis and treatment of obstructive sleep apnea (1988)

A detailed cephalometric analysis was conducted on lateral x-rays from 30 adult patients with obstructive sleep apnea (OSA) and 12 age- and sex-matched controls. Statistical findings show that OSA patients are different from controls in at least five ways: 1. Their tongue and soft palate are significantly enlarged. 2. The hyoid bone is displaced inferiorly. 3. The mandible is normal in size and position (no micrognathia or malocclusion), but the face is elongated by an inferior displacement of the mandibular body. 4. The maxilla is retropositioned and the hard palate elongated. 5. The nasopharynx is normal, but the oropharyngeal and hypopharyngeal airway is reduced in area by an average of 25%, a factor that could produce or enhance OSA symptoms. These data suggest that cephalometric evaluation could be useful when used with head and neck examination, polysomnographic and endoscopic studies to evaluate OSA patients, and to assist with the planning/surgical treatment for improvement of upper airway patency.
Autocrine motility factor and the extracellular matrix. I. Coordinate regulation of melanoma cell adhesion, spreading and migration involves focal contact reorganization (1998)

Cellular interactions with the extracellular matrix are complex and are involved in numerous biological processes. These interactions may be modulated by cytokines such as tumor cell autocrine motility factor, a secreted molecule that regulates cellular growth and migration by a receptor-mediated pathway. In this report we provide evidence suggesting that high- and low-metastatic K1735 melanoma cells coordinate their attachment, spreading and migratory responses to autocrine motility factor and the extracellular substratum through alterations in focal adhesion plaque architecture that are dependent on both inherent cellular metastatic phenotype and the composition of the supporting matrix. Thus, since activation of the autocrine motility factor receptor has previously been shown to enhance the experimental metastasis of the high- but not the low-metastatic K1735 cells, differences in melanoma cell malignancy in this system may be due in part to a coordinated interplay between cytokine-mediated responses and extracellular matrix-directed regulation of cellular adhesion, spreading and motility.
Mutual-Information-Based Adaptive Bit-Loading Algorithms for LDPC-Coded OFDM (2007)

In this paper we analyze the performance of an LDPC-coded OFDM system with adaptive bit-loading based on mutual information. We demonstrate that the mutual information between the transmitted binary sequence and the soft information input to LDPC decoder well characterizes the performance of the LDPC-coded system, independent of the modulation type and the number of carriers. We design mutual information-based adaptive bit-loading and power allocation algorithms for LDPC-coded OFDM systems to maximize throughput performance under a packet-error rate constraint. To characterize the performance of the system under study, we derive the achievable information rate and a throughput upper bound for the system
Liver iron deposits in hepatitis B patients: Association with severity of liver disease but not with hemochromatosis gene mutations (2004)

Elevated TS and liver iron deposits were frequent in non-cirrhotic HBV patients. Iron deposits were mainly mild and associated with higher activity and severity of liver disease, but not with HFE mutations.
A TDR Method for Real-Time Monitoring of Liquids (2007)

Time-domain-reflectometry (TDR) measurements, which were originally used to locate and diagnose faults in transmission lines, have been widely applied in geology and soil science for accurate and flexible measurements of soil moisture and water content. Furthermore, the most attractive advantages of TDR rely on the possible determination of the spatial location and nature of various objects, both in real time and with a nondestructive approach. This makes the TDR technique an appealing candidate for a variety of environmental and industrial applications. Although the TDR instruments are commonly used to date, particularly for the aforementioned purposes, the state of the art is rather lacking in liquid-monitoring applications. This paper describes how the suitable combination of TDR detecting functionalities can lead to a simultaneous monitoring of quantitative and qualitative properties of liquid samples. In fact, the proposed TDR method allows, in one shot, the measurement of liquid levels, the determination of multiple interfaces in layered media, and the evaluation of dielectric properties such as dielectric permittivity or electrical conductivity. Some applications to real cases are proposed, which are referred to petrol-chemical mixtures or water-based liquids, thus validating the approach on a wide range of materials.
Leishmania-Mediated Inhibition of Iron Export Promotes Parasite Replication in Macrophages (2014)

Leishmania parasites infect macrophages, cells that play an important role in organismal iron homeostasis. By expressing ferroportin, a membrane protein specialized in iron export, macrophages release iron stored intracellularly into the circulation. Iron is essential for the intracellular replication of Leishmania, but how the parasites compete with the iron export function of their host cell is unknown. Here, we show that infection with Leishmania amazonensis inhibits ferroportin expression in macrophages. In a TLR4-dependent manner, infected macrophages upregulated transcription of hepcidin, a peptide hormone that triggers ferroportin degradation. Parasite replication was inhibited in hepcidin-deficient macrophages and in wild type macrophages overexpressing mutant ferroportin that is resistant to hepcidin-induced degradation. Conversely, intracellular growth was enhanced by exogenously added hepcidin, or by expression of dominant-negative ferroportin. Importantly, dominant-negative ferroportin and macrophages from flatiron mice, a mouse model for human type IV hereditary hemochromatosis, restored the infectivity of mutant parasite strains defective in iron acquisition. Thus, inhibition of ferroportin expression is a specific strategy used by L. amazonensis to inhibit iron export and promote their own intracellular growth.
Integrating Science Gateways with XSEDE Security (2014)

We present a survey of credential management approaches for science gateways to integrate with the X.509 security infrastructure used by XSEDE.
Suppression of larval Colorado potato beetle growth and development by digestive proteinase inhibitors (1987)

Abstract Evidence is presented that the Colorado potato beetle (CPB) ( Leptinotarsa decemlineata (Say)) depends, at least partially, on cysteine proteinases for protein digestion. Midgut homogenates of CPB larvae have a mildly acidic pH and exhibit major proteolytic activity in the mildly acidic pH range. This proteolytic activity is activated by reducing agents, is inhibited by E‐64 (a specific cysteine proteinase inhibitor), and is not inhibited by serine proteinase inhibitors. In addition, consumption of E‐64 treated potato leaves by CPB larvae at rates as low as 0.8 μg/cm 2 of leaf tissue has a deleterious effect on larval growth and development. Résumé Suppression par des inhibiteurs de protéinases intestinales, de la croissance et du développement des larves de doryphores Les protéinases intestinales des larves de Leptinotarsa decemlineata sont en partie caractérisées par les pH limitant leur activité, et par l'effet d'inhibiteurs de protéinases de spécificités connues. Les protéinases ont été testées avec la méthémoglobine tritiée comme substrat et nous avons déterminé les taux relatifs de peptides radioactives TCA solubles, libérées, dans des conditions précises, pour des pH compris entre 2,0 et 12,0. Le taux le plus élevé d'activité protéolytique a été observé pour des pH 5,0 à 6,0, bien qu'il y ait eu une activité appréciable aux pH 4,0 et 8,0. Parmi les inhibiteurs examinés, le E‐64, inhibiteur protéinase cystéine très sélectif, a été le plus efficace sur l'activité protéinase. La pepstatine, inhibiteur protéinase aspartique, a été actif, mais seulement dans une gamme plus moin de pH. Les inhibiteurs protéinase sérine, ont été pratiquement inactifs sur l'activité protéinase. Chez des larves de doryphores nourries de feuilles de pommes de terre traitées avec différentes concentrations de E‐64 ou de pepstatine, la consommation de E‐64 a retardé fortement la croissance larvaire et le développement, la pepstatine a provoqué un retard du développement plus limitée. Nos résultats suggèrent que le doryphore dépend, tout au moins partiellement, des protéinases cystéine pour l'assimilation des protéines.
Identification of human plasma cholinesterase variants in 6,688 individuals using biochemical analysis (1995)

In 1973, a Cholinesterase Research Unit was established in Denmark (DCRU). The primary aim was to provide a central service for determining genotypes and activity of plasma cholinesterase (BChE) in patients showing abnormal response after succinylcholine. The purpose of the present study was, on the basis of 20 years experience with this Unit, to establish accurate reference intervals for BChE activity and inhibition values for the different genotypes of BChE. Also we wanted to evaluate the influence of age and sex on the BChE activity in genotypically normal patients. Plasma cholinesterase activity was measured using benzoylcholine as substrate. The genetic variations of the enzyme were identified using differential inhibitors, i.e.: Dibucaine, Sodium Fluoride, Succinylcholine, Urea and Ro-2-0683. We investigated 6,688 patients. The reference values for the 13 genotypes represented agree with previous findings. In genotypically normal patients, no age or sex differences were found in BChE activity in children below the age of 10 years. From the age of 10 years the activity decreased significantly in both males and females, the activity in females being significantly lower than in males. In females the activity was lowest in the age group 30-40 years, returning to prepuberty level at about 60 years of age. In males the activity decreased slightly up to 50-60 years of age. Hereafter the activity was stable or tended to increase slightly. Most genotypes could be recognized using the results of the different inhibition studies. We found the inhibitors Dibucaine, Sodium fluoride, Urea and Ro-2-0683 most helpful, whereas succinylcholine was of less value.(ABSTRACT TRUNCATED AT 250 WORDS)
Input Test Data Compression Based on the Reuse of Parts of Dictionary Entries: Static and Dynamic Approaches (2013)

In this paper, we present a new test data compression method for intellectual property (IP) cores testing, based on the reuse of parts of dictionary entries. Two approaches are investigated: the static and the dynamic. In the static approach, the content of the dictionary is constant during the testing of a core, while in the dynamic approach the testing of a core consists of several test sessions and the content of the dictionary is different during each test session. The efficiency of the proposed method is supported with extensive simulation results and comparisons to already known test data compression methods suitable for IP cores testing.
Australia examines new routes to solar energy supply (1976)

The director of the Commonwealth Scientific and Industrial Research Organization, Roger Morse, believes that solar energy, with oil from coal, could make Australia independent of imported oil by the year 2000. Speaking at a symposium on solar energy resources, he suggested that at least half of the nation's liquid fuel requirements for transport could be produced from plant cellulose in the form solar ethanol. The ethanol could supply Australia's motor spirit requirements and oil distilled from coal could provide the country's heavy oil and distillate needs. Production of liquid fuels from forests involves the harvesting of the whole tree on a 10-year rotation in which the nutrients taken up by the tree are recycled. Marginal, unirrigated land could be used without large applications of energy-consuming fertilizers. The chemical conversion involves hydrolysis of cellulose to sugars and fermentation of the sugars to alcohol. Morse envisages that about 30 complexes, each comprising a forest plantation and a hydrolysis and fermentation processing plant, should be set up throughout Australia. Solar ethanol economics and the continuing studies on silicon solar cells are discussed briefly. (MCW)
Miniature Broadband NIR Spectrometer Based on FR4 Electromagnetic Scanning Micro-Grating (2020)

This paper presents a miniaturized, broadband near-infrared (NIR) spectrometer with a flame-retardant 4 (FR4)-based scanning micrograte. A 90° off-axis parabolic mirror and a crossed Czerny-Turner structure were used for creating an astigmatism-free optical system design. The optical system of the spectrometer consists of a 90° off-axis parabolic mirror, an FR4-based scanning micrograte, and a two-color indium gallium arsenide (InGaAs) diode with a crossed Czerny-Turner structure optical design. We used a wide exit slit and an off-axis parabolic mirror with a short focal length to improve the signal-to-noise ratio (SNR) of the full spectrum. We enabled a miniaturized design for the spectrometer by utilizing a novel FR4 micrograte for spectral dispersion and spatial scanning. The spectrometer can detect the full near-infrared spectrum while only using a two-color InGaAs diode, and thus, the grating scanning angle of this spectrometer is small when compared to a dual-detector-based spectrometer. In addition, the angle signal can be obtained through an angle sensor, which is integrated into the scanning micrograte. The real-time angle signal is used to form a closed-loop control over the scanning micrograte and calibrate the spectral signal. Finally, a series of tests was performed. The experimental results showed that the spectrometer has a working wavelength range of 800-2500 nm. The resolution is 10 nm at a wavelength range of 800-1650 nm and 15 nm at a wavelength range of 1650-2500 nm. Similarly, the stability of these two wavelength ranges is better than ±1 nm and ±2 nm, respectively. The spectrometer's volume is 80 × 75 × 65 mm<sup>3</sup> and its weight is 0.5 kg. The maximum spectral fluctuation does not exceed 1.5% and the signal-to-noise ratio is 284 after only one instance of averaging.
30-MJ superconducting magnetic energy storage system for electric utility transmission stabilization (1983)

A superconducting magnetic energy storage (SMES) system has been built to damp power oscillations on the Western U.S. Power System, particularly on the Pacific AC Intertie that is used to transmit power from the Northwest to southern California. The 30-MJ superconducting inductor that stores energy for this purpose is contained in a nonconducting dewar and is supported by a helium refrigerator and a gas-handling system mounted on trailers. Energy flows in and out of the inductor at frequencies from 0.1 to 1.0 Hz with power amplitudes up to 11 MW. The principal oscillation to be damped has a characteristic frequency of 0.35 Hz. The superconducting coil maximum current is 5 kA with terminal voltages up to 2.2 kV. The coil interfaces with the Bonneville Power Administration 13.8-kV bus at the Tacoma Substation through a converter and transformers. The system can be operated with the converter either in parallel-bridge mode or for constant VAR control with the bridges in buck-boost mode. The program for the design, fabrication, installation, and the preliminary experimental operation of the system is reviewed.