gebhart/patrepeval huggingface dataset:
Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice (2006)

TIRC7 is a cell surface molecule which is expressed in T and B lymphocytes and negatively regulates their function. Anti-TIRC7 specific monoclonal antibody (mAb) inhibited T cell memory response to recall antigens. Up-regulation of TIRC7 on lymphocytes from joint tissue of patients with Rheumatoid Arthritis (RA) and mice with collagen induced arthritis (CIA) suggested TIRC7 as a novel target to promote anti-inflammatory reaction. Anti-TIRC7 mAb administration significantly inhibited the induction and progression of CIA and the anti-collagen IgG1 and IgG2a antibody response. Combination therapy of anti-TIRC7 mAb and soluble TNF-alpha receptor demonstrated an increased inhibitory effect over the single compounds on CIA. The results demonstrate the therapeutic potential of TIRC7 targeting with mAb in diseases associated with exaggerated T and B cell responses.
Relationship of the syntheses of spore coat protein and parasporal crystal protein in Bacillus thuringiensis (1982)

Two major classes of polypeptides were extracted from the spore surface of Bacillus thuringiensis subsp. kurstaki: the 134,000-dalton protoxin that is the major component of the crystalline inclusion and spore coat polypeptides very similar to those found on Bacillus cereus spores. The quantity of spore coat polypeptides produced was reduced when compared with that produced by certain acrystalliferous mutants or by B. thuringiensis subsp. israelensis. The latter organism produced an inclusion toxic to mosquito larvae, but deposited very little of the inclusion protein on the spore surface. The reduction in spore coat protein in B. thuringiensis subsp. kurstaki was also seen in freeze-etched electron micrographs of spores. B. thuringiensis subsp. kurstaki spores germinated rather slowly when compared with related species, a property previously correlated with a deficiency or defect of the spore coat. Many mutants of B. thuringiensis subsp. kurstaki unable to form a crystalline inclusion were nontoxic and lacked a well-defined spore coat. Other mutants isolated either directly from the wild type or from coat-deficient mutants produced spores that were identical to those produced by the closely related species. Bacillus cereus, on the basis of morphology, germination rate, and the size and antigenicity of the spore coat polypeptides. Most of the protein extractable from the inclusion produced by B. thuringiensis subsp. israelensis was about 26,000 daltons, considerably smaller than the major polypeptide extractable from other inclusions. Some of the B. thuringiensis subsp. israelensis inclusion protein was found on the spore surface, but the majority of the extractable spore coat protein was the same size and antigenicity as that found on B. cereus spores. The B. thuringiensis subsp. israelensis spores germinated at a rate close to that of B. cereus, especially when the spores were formed at 37 degrees C, and the morphology of the spore surface was very similar to that of B. cereus.
Notechis 11′2, a non‐toxic phospholipase A<sub>2</sub> from the venom of <i>Notechis scutatus scutatus</i> (1991)

Previously, we deduced the amino acid sequence of a novel phospholipase-A2-like protein (PLA2) from the nucleotide sequence of a cDNA isolated from a library prepared from the venom gland of the Australian elapid Notechis scutatus scutatus. The corresponding protein has now been identified, purified from the venom and named Notechis 11'2. Its complete amino acid sequence has been determined by automated Edman degradation of both the whole protein and peptides generated by Staphylococcus aureus protease digestion and chemical cleavage at a tryptophan residue. As predicted from its sequence which contains all the residues putatively required for PLA2 activity, Notechis 11'2 exhibits an esterase activity, preferentially against neutral phospholipids. However, despite its sequence homology with other highly toxic PLA2 present in the venom of Notechis scutatus scutatus, notechis 11'2 has no lethal activity. This observation further supports the view that the lethal activity of PLA2 from Notechis scutatus scutatus is not due to the esterasic activity only.
In vivo histotripsy brain treatment (2018)

Histotripsy can be used to generate sharply defined lesions of arbitrary shapes and sizes in the swine cortex. Lesions confined to within the gyri did not lead to significant hemorrhage or edema responses at the treatment site in the acute or subacute time intervals.
Human herpesvirus 7: antigenic properties and prevalence in children and adults (1991)

The recent isolation of human herpesvirus 7 (HHV-7) from activated CD4+ T lymphocytes of a healthy individual raises questions regarding the prevalence of this virus in humans and its immunological relationship to previously characterized human herpesviruses. We report that HHV-7 is a ubiquitous virus which is immunologically distinct from the highly prevalent T-lymphotropic HHV-6. Thus, (i) only two of six monoclonal antibodies to HHV-6 cross-reacted with HHV-7-infected cells, (ii) Western immunoblot analyses of viral proteins revealed different patterns for HHV-6- and HHV-7-infected cells, (iii) tests of sequential serum samples from children revealed seroconversion to HHV-6 without concomitant seroconversion to HHV-7, and (iv) in some instances HHV-7 infection occurred in the presence of high titers of HHV-6 antibodies, suggesting the lack of apparent protection of children seropositive for HHV-6 against subsequent infection with HHV-7. On the basis of the analyses of sera from children and adults it can be concluded that HHV-7 is a prevalent human herpesvirus which, like other human herpesviruses, infects during childhood. The age of infection appears to be somewhat later than the very early age documented for HHV-6.
Chemically modified photochemical cell (1983)

A chemically modified photoelectrochemical cell is disclosed including at least one cathode and a plurality of anodes, at least said plurality of anodes being constituted with a semiconductor, each of said plurality of anodes being formed by fixing through covalent bonds molecules of at least one sensitizer dye on the surface of a light-transmissible flat plate of an n-type semiconductor or a light-transmissible flat plate covered with a thin film of an n-type semiconductor, and said plurality of anodes being disposed parallelly to each other and in the form of layers in an electrolyte solution, together with said at least one cathode. Thus, since this photoelectrochemical cell can convert photoenergy of a longer wavelength to electric energy with a high efficiency by making the use of the dye sensitization effect, sufficient practical utility to the photodevices is obtained.
Single-shot network analyzer for extremely fast measurements (2016)

A new instrument for fast measurement of frequency response of high-bandwidth optical and electronic devices is reported. Single-shot frequency spectrum measurements are enabled by time-stretch technology. An extremely fast measurement time of 27 ns is reported for the instrument. The reported instrument enables single-shot impulse response measurements with a 40 GHz bandwidth, which could be extended to beyond 100 GHz by using a faster electro-optic modulator. An ultra-low jitter of 20.5 fs is reported for the proposed instrument. The impulse responses measured using this technique are shown to correspond consistently with the manufacturer's specifications for the device under test. The reported instrument makes possible high-speed network parameter measurements, thereby enabling high-speed production-level testing of high-bandwidth opto-electronic devices/circuits/subsystems/systems and complex permittivity measurement of dielectric materials at a much reduced test time, lowering the test costs in a production environment.
A new solid‐phase polymerization—metal phthalocyanine sheet polymers (1983)

Abstract The thermal reactions of pure metal(11) 4,4′,4″,4′″‐phthalocyanine‐tetracarboxylic acids of copper, cobalt, and nickel at 350–400°C in vacuum have been studied using Fourier transform infrared spectrometry, gas chromatography, and mass spectrometry. Based on these observations, novel in situ reactions for the synthesis of heat‐resistant phthalocyanine “sheet” polymers are described. The poly(metal phthalocyanine) polymers of copper, cobalt, and nickel so synthesized have been characterized by elemental analysis, infrared spectroscopy, and dynamic thermogravimetric analysis. The most noteworthy property of these polymers is their extreme resistance to heat in an anaerobic atmosphere and their high char yields (89–93%) at 800°C in a nitrogen atmosphere.
Keyboard-type automatic accompanying system (1981)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Yasuhiko Okuyama, Koji Tanaka, Yoshiro Nakayama, Hiroshi Kato; Keyboard‐type automatic accompanying system. J. Acoust. Soc. Am. 1 May 1981; 69 (5): 1540. https://doi.org/10.1121/1.385709 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
SixthSense (2008)

RFID is widely used to track the movement of goods through a supply chain. In this paper, we extend the domain of RFID by presenting SixthSense, a platform for RFID-based enterprise intelligence systems. We consider an enterprise setting where people (or rather their employee badges) and their personal objects such as books and mobiles are tagged with cheap, passive RFID tags, and there is good coverage of RFID readers in the workplace. SixthSense combines mobility information obtained from RFID-based sensing with information from enterprise systems such as calendar and presence, to automatically draw inferences about the association and interaction amongst people, objects, and workspaces. For instance, SixthSense is able to automatically distinguish between people and objects, learn the identities of people, and infer the ownership of objects by people.
Circadian system modeling and phase control (2010)

Circadian rhythms are biological processes found in all living organisms, from plants to insects to mammals that repeat with a period close to, but not exactly, 24 hours. In the absence of environmental cues, circadian rhythms oscillate with a period slightly longer or shorter than 24 hours. The 24-hour patterns of light and dark are the strongest synchronizer of circadian rhythms to the solar day. Circadian disruption resulting from lack of synchrony between the solar day and the internal master clock that regulates and generates circadian rhythms had been linked to a variety of maladies. Circadian disruption, as experienced by night shift workers or by those traveling multiple time zones can lead to lower productivity, digestive problems and decreased sleep efficiency. Long-term circadian disruption has been linked to serious health problems, such as increased risk of cancer, cardiovascular disease, diabetes and obesity. Biochemical and empirical mathematical models describing the circadian clock and its response to light input have been developed by various research groups. Biochemical models describe the kinetics of the interaction between different proteins and may be of high order depending on the complexity of the model. Empirical models are based on nonlinear oscillators, such as the van der Pol oscillator, and are, therefore, much simpler. Though empirical models do not have a biochemical basis, it has been shown that they do represent the averaged asymptotic behavior of the biochemical models. In this paper, we analyze a simple empirical model proposed by Kronauer and colleagues and discuss how light control may be used to promote circadian entrainment. In contrast to most of the existing approaches, which are based on phase response curves, we propose a feedback-based system. Through simulation, we show that the recovery of a 12-hour jet lag can be shortened from 7 days to 2.5 days.
Multiuser rate-diverse network-coded multiple access (2017)

This paper presents the first Network-Coded Multiple Access (NCMA) system with multiple users adopting different signal modulations, referred to as rate-diverse NCMA. A distinguishing feature of NCMA is the joint use of physical-layer network coding (PNC) and multiuser decoding (MUD) to boost throughput of multipacket reception systems. In previous NCMA systems, users adopt the same modulation regardless of their individual channel conditions. This leads to suboptimal throughput for many practical scenarios, especially when different users have widely varying channel conditions. A rate-diverse NCMA system allows different users to use modulations that are commensurate with their channel conditions. A key challenge is the design of PNC mapping and decoding mechanisms in NCMA when different users adopt different modulations. While there have been past work on non-channel-coded rate-diverse PNC, this paper is the first attempt to design channel-coded rate-diverse PNC to ensure the reliability of the overall NCMA system. Specifically, we put forth a symbol-splitting channel coding and modulation design so that PNC/NCMA can work over different modulations. We implemented our rate-diverse NCMA system on software-defined radios. Experimental results show that the throughput of rate-diverse NCMA can outperform the state-of-the-art rate-homogeneous NCMA by 80%. Overall, the introduction of rate diversity significantly boosts the NCMA system throughput in practical scenarios.
A Series DC Arc Fault Detection Algorithm Based on PV Operating Characteristics and Detailed Extraction of Pink Noise Behavior (2021)

Traditional arc fault detection methods focus on the time domain or the frequency domain of the current signal as an indicator of a possible arc fault event. However, the pink noise generated by the arc fault is usually observed only as an increase in energy and not specifically characterized, leading to unwanted tripping from other arc-like transients. In this research, the pink noise analysis, along with unique properties of the PV operating point of both the instantaneous current and voltage signal, is used to distinguish arc faults from other noisy loads or PV degradations. Experimental results validate that the algorithm successfully detects series DC arc faults.
Recurrent missense mutations in TMEM43 (ARVD5) due to founder effects cause arrhythmogenic cardiomyopathies in the UK and Canada (2012)

Although the p.R312W variant was found in controls (3/378), identification of an ancestral disease p R312W haplotype suggests that the p.R312W variant is a pathogenic founder mutation.
High dielectric constant composites for high power antennas (2011)

The volume and weight of high power antennas can be a limiting factor for compact pulsed power transmitters. Options for antenna minimization are limited due to the relationship between an antenna's physical dimensions and the frequencies which can be transmitted. Thus, low frequency antennas often require dimensions on the order of meters. An effort undertaken at the University of Missouri addresses these fundamental constraints on antenna size by developing and integrating high dielectric constant composite materials that can reduce the physical size of high power antennas. Traditional high dielectric constant materials, including sintered perovskite ceramics, are not well suited for integration in high power antennas due to their low dielectric strength, poor mechanical properties, and limitations in forming complex shapes. Therefore, a composite material is necessary for improved dielectric strength and mechanical properties over sintered ceramics while maintaining a high dielectric constant. Previous research on high dielectric constant composite materials has primarily been focused on low power applications for embedded capacitors. The development of composites for high power systems presents additional challenges, including large thickness and high dielectric strength requirements for high voltage use and the capability to be formed or machined into complex geometries. Three distinct classes of high dielectric constant composites have been developed through this effort. The three classes of composites are characterized by the range of dielectric constant values measured at frequencies from 200 MHz to 4.5 GHz. The first composite class can be manufactured with a dielectric constant of 30-50 and exhibits the best machining properties of the three classes. The second composite class has a dielectric constant of 80-100, is easily machined, and has a loss tangent of less than 0.12 up through at least 4.5 GHz. The third composite class has the highest dielectric constant at between 350 and 550, is easily machined, and is well-suited for operation at frequencies of a few hundred MHz. Three crucial dielectric measurements for high dielectric constant composites for high power components are reported. First, the complex permittivity is given in the frequency range from 200 MHz to 4.5 GHz. Second, the pulsed dielectric strength is reported as the cumulative probability of breakdown measured from a set of samples of each composite class. Lastly, the electric field dependence of each composite's dielectric constant is reported through polarization measurements taken on a custom high voltage test stand.
Structure-Based Design and Synthesis of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors (2004)

We disclose optimization efforts based on the novel non-nucleoside adenosine deaminase (ADA) inhibitor, 4 (K(i) = 680 nM). Structure-based drug design utilizing the crystal structure of the 4/ADA complex led to discovery of 5 (K(i) = 11 nM, BA = 30% in rats). Furthermore, from metabolic considerations, we discovered two inhibitors with improved oral bioavailability [6 (K(i) = 13 nM, BA = 44%) and 7 (K(i) = 9.8 nM, BA = 42%)]. 6 demonstrated in vivo efficacy in models of inflammation and lymphoma.
Chase & Backchase: A Method for Query Optimization With Materialized Views and Integrity Constraints (2001)

We have previously proposed chase and backchase as a novel method for using materialized views and integrity constraints in query optimization. In this paper, we show that the method is usable in realistic optimizers by extending it to bag and mixed (i.e. bag-set) semantics as well as to grouping views and by showing how to integrate it with standard cost-based optimization. We understand materialized views broadly, including user-defined views, cached queries and physical access structures (such as join indexes, access support relations, and gmaps). Moreover, our internal query representation supports object features hence the method applies to OQL and (extended) SQL: 1999 queries. Chase and backchase supports a very general class of integrity constraints, thus being able to find execution plans using views that do not fall in the scope of other methods. In fact, we prove completeness theorems that show that our method will find the best plan in the presence of common and practically important classes of constraints and views, even when bag and set semantics are mixed. We report on a series of experiments that demonstrate the practicality of our new ideas.
Continuous bed motion (CBM) uniform sensitivity emission image with partially known axial attenuation information, available from CT scans (2014)

2083 Objectives In PET-CT, the axial length of image reconstruction is defined by the CT scan, which delivers an axial extend-dependent dose of radiation. Still the CBM acquisition results in over-scanning, where more data are acquired than are needed to reconstruct targeted volumes of interest. The end planes will have lower sensitivity due to the absence of oblique LOR attenuation factors. Nevertheless, recent investigations concluded that both activity and attenuation distributions can be obtained from PET emission TOF data alone. The maximum-likelihood activity and ACF estimation (MLACF) iterative algorithm reconstructs the emission image, with estimation of partially unknown ACFs. Methods The patient data were acquired in the list mode file on a Siemens mCT scanner. The patient was scanned with 1mm/s bed speed. The full 44 cm CT volume was acquired but it was assumed that axially short (PET scanner length, 22 cm) CT volume would be known. The CBM PET sinogram was generated where direct PET planes, corresponding to 22 cm CT volume, had axially uniform sensitivity. This led to over-scanning and the use of additional data resulted in 44 cm extended PET volume. Three images were generated. One was a gold standard OSEM reconstruction, where full 44 cm CT information was used. Another was MLACF reconstruction, where only known 22 cm CT information was used. Both reconstructions resulted in extended PET volume and part of the image, 22 cm uniform sensitivity PET volume corresponding to the short CT volume, was extracted. The third image was OSEM reconstruction of the short 22 cm PET volume. Results The MLACF resulted in slower convergence of end planes. However, they are of similar quality to the gold standard, while the OSEM reconstruction (shorter volume) showed degraded end planes. Conclusions The known CT volume can be effectively and theoretically exactly extended in the axial direction, based on available emission data. This leads to clinically useable CBM PET image end planes.
Abstract 1870: Development of a standard operating procedure for exosome isolation and analysis using clinical samples: Application to cancer biomarker discovery (2014)

Abstract Exosomes are small vesicles (30-150 nm) found in abundance in human body fluids which function as carriers of different species of RNA and protein between diverse locations in the body. The spectrum of current scientific interest in exosomes is wide and ranges from studying their functions and pathways to utilizing them in diagnostics and therapeutics development. As such, there is a growing need for quick and easy methods for both isolation of exosomes and analysis of their cargo. We present herein a workflow for exosome isolation and analysis which entails: (i) fast and efficient isolation of exosomes from serum, plasma, and urine of both healthy donors and patients with prostate cancer, using Total Exosome Isolation reagents; (ii) characterization of their size distribution and count with Nanosight LM10 instrument; (iii) extraction of exosome “cargo” with Total Exosome RNA and Protein Isolation kit; (iv) characterization of exosomal RNA content using the Ion Torrent PGM sequencing and qRT-PCR. The protocol described herein lays the groundwork for the development of a standardized operating procedure (SOP) for isolation of exosomes and downstream analysis of their constituents, using clinical samples. We demonstrate that cancer-specific RNA signatures residing within the exosomes can be delineated from different patient cohorts. This is the first step towards developing a method whereby performance characteristics can be measured and used to optimize a validated assay useful for routine testing of clinical samples. Citation Format: Robert A. Setterquist, Alex J. Rai, Emily Zeringer, Mu Li, Tim Barta, Jeoffrey Schageman, Susan Magdaleno, Alexander V. Vlassov. Development of a standard operating procedure for exosome isolation and analysis using clinical samples: Application to cancer biomarker discovery. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1870. doi:10.1158/1538-7445.AM2014-1870