gebhart/patrepeval huggingface dataset:
Data from Molecular Inhibitor of QSOX1 Suppresses Tumor Growth <i>In Vivo</i> (2023)

<div>Abstract<p>Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme overexpressed by many different tumor types. QSOX1 catalyzes the formation of disulfide bonds in proteins. Because short hairpin knockdowns (KD) of QSOX1 have been shown to suppress tumor growth and invasion <i>in vitro</i> and <i>in vivo</i>, we hypothesized that chemical compounds inhibiting QSOX1 enzymatic activity would also suppress tumor growth, invasion, and metastasis. High throughput screening using a QSOX1-based enzymatic assay revealed multiple potential QSOX1 inhibitors. One of the inhibitors, known as “SBI-183,” suppresses tumor cell growth in a Matrigel-based spheroid assay and inhibits invasion in a modified Boyden chamber, but does not affect viability of nonmalignant cells. Oral administration of SBI-183 inhibits tumor growth in 2 independent human xenograft mouse models of renal cell carcinoma. We conclude that SBI-183 warrants further exploration as a useful tool for understanding QSOX1 biology and as a potential novel anticancer agent in tumors that overexpress QSOX1.</p></div>
In Situ Stripline Electrochemical NMR for Batteries (2018)

Abstract Some long‐outstanding technical challenges exist that continue to be of hindrance to fully harnessing the unique investigative advantages of nuclear magnetic resonance (NMR) spectroscopy in the in situ investigation of rechargeable battery chemistry. For instance, the conducting materials and circuitry necessary for an operational battery always deteriorate the coil‐based NMR sensitivity when placed inside the coil, and the shape mismatch between them leads to low sample filling factors and even higher detection limits. We report, herein, a novel and successful adaptation of stripline NMR detection that integrates seamlessly NMR detection with the construction of an electrochemical device in general, or a battery in particular, which leads to an in situ electrochemical NMR technique with much higher detection sensitivity, higher sample filling factor, and which is particularly suitable for mass‐limited samples.
A Language-independent and Compositional Model for Personality Trait Recognition from Short Texts (2017)

There have been many attempts at automatically recognising author personality traits from text, typically incorporating linguistic features with conventional machine learning models, e.g.linear regression or Support Vector Machines.In this work, we propose to use deep-learningbased models with atomic features of text -the characters -to build hierarchical, vectorial word and sentence representations for the task of trait inference.On a corpus of tweets, this method shows stateof-the-art performance across five traits and three languages (English, Spanish and Italian) compared with prior work in author profiling.The results, supported by preliminary visualisation work, are encouraging for the ability to detect complex human traits.
Crack Propagation Measurement Using a Battery-Free Slotted Patch Antenna Sensor (2014)

This research studies the performance of a battery-free wireless antenna sensor for measuring crack propagation. In our previous work, a battery-free folded patch antenna was designed for wireless strain and crack sensing. When experiencing deformation, the antenna shape changes, causing shift in electromagnetic resonance frequency of the antenna. The wireless interrogation system utilizes the principle of electromagnetic backscattering and adopts off-the-shelf 900MHz radiofrequency identification (RFID) technology. Following the same sensing mechanism, a slotted patch antenna sensor of smaller size is designed. The antenna detours surface current using slot patterns, so that the effective electrical length is kept similar as previous folded patch antenna. As a result, the sensor footprint is reduced and the antenna resonance frequency is maintained within 900MHz RFID band. To validate the sensor performance for crack sensing, a fatigue crack experiment is conducted on a steel compact-tension specimen. A slotted patch antenna sensor is installed at the center of the A36 steel specimen. For wireless interrogation, a Yagi reader antenna is placed 36 in. away from the antenna sensor to wirelessly measure the resonance frequency shift of the antenna sensor. The measurement is taken after every 10,000 loading cycles, till the specimen fails. Meanwhile, the length and width of the fatigue crack are also recorded. Finally, the resonance frequency shift of the antenna sensor is correlated with crack length and width at each loading stage.
S-band amplification in a thulium doped silicate fiber (2002)

We demonstrate significant gain over 1470-1540 nm in a thulium doped silica fiber amplifier. The fiber is compatible with standard fabrication techniques, and can be fusion spliced to standard telecommunications fibers. we report the first demonstration of an S-band thulium doped fiber amplifier (TDFA) using a true silicate fiber host which is readily spliced to standard fibers and compatible with standard fabrication technologies. Modifications in composition are expected to yield improvements in lifetime which may enable a truly practical TDFA.
Efficient thulium-doped 2-/spl mu/m germanate fiber laser (2005)

We report an efficient fiber laser operating near 2 μm. The glass for the fiber is germanate that is highly doped with thulium. The effect of cross relaxation energy transfer between thulium ions as observed from emission spectrum of the glass samples results in the laser having a very high slope efficiency of 58% with respect to launched power. This corresponds to a quantum efficiency of 1.79, indicating that each pump photon leads to near 1.8 excited Tm/sup 3+/ ions.
A Novel Capacitive Detection Scheme With Inherent Self-Calibration (2007)

This paper reports a novel capacitive detection method which is robust to variations of such critical parameters as the nominal capacitance, frequency and amplitude of the probing voltage, and gain of the trans-impedance amplifier. The approach constructively utilizes inherent nonlinearity of parallel plate sense capacitors in order to measure amplitude of sinusoidal motion. In the case of parallel plate detection signal, multiple harmonics exist and carry redundant information about the amplitude of mechanical motion. The amplitude of motion can be extracted from the ratio of two simultaneously measured harmonics. The paper presents details of a real-time measurement algorithm. Functionality of the algorithm is confirmed by simulations and experiments. The technique is especially valuable for capacitive detection and self-calibration in resonant structures, such as gyroscopes, resonant microbalances, and chemical sensors.
Scanning frequency comb microscopy—A new method in scanning probe microscopy (2018)

A method for superimposing a microwave frequency comb (MFC) on the DC tunneling current in a scanning tunneling microscope (STM) is described in which a mode-locked laser is focused on the tunneling junction. The MFC is caused by optical rectification of the regular sequence of laser pulses due to the nonlinear current-voltage characteristics of the tunneling junction. Hundreds of harmonics, at integer multiples of the laser pulse-repetition frequency, are generated with a metal tip and sample. However, the harmonics have less power with a resistive sample due to the loss in its spreading resistance. The microwave power is greatest at a tip-sample distance that is unique for each sample resistivity. This distance may be set by using different pairs of the applied DC bias and the set-point for the DC tunneling current. However, the laser, and not the applied DC bias or the DC tunneling current, is the source of energy for the MFC so they are not required. Feedback control of the tip-sample distance may be based on maximizing the attowatt-level microwave power of the harmonics, which have a signal-to-noise ratio of 20 dB. This method shows promise for nondestructive carrier profiling of semiconductors with true sub-nanometer resolution which is essential in the continued progress below the 40-nm technology node. It may enable carrier profiling with 2-D materials such as graphene, and it also shows promise for finer resolution in images of biological materials or other resistive samples.
Versatile retargeting of SH3 domain binding by modification of non‐conserved loop residues (2007)

Src-homology (SH3) domain belongs to a class of ubiquitous modular protein domains found in nature. SH3 domains have a conserved surface that recognises proline-rich peptides in ligand proteins, but additional contacts also contribute to binding. Using the SH3 domain of hematopoietic cell kinase as a test case, we show that SH3 binding properties can be profoundly altered by modifications within a hexapeptide sequence in the RT-loop region that is not involved in recognition of currently known consensus SH3 target peptides. These results highlight the role of non-conserved regions in SH3 target selection, and introduce a strategy that may be generally feasible for generating artificial SH3 domains with desired ligand binding properties.
Split vector quantization of signals in multiple transform domains with application to speech (2002)

A novel multiple transform split vector quantization (MTSVQ) scheme where each signal vector is projected into multiple transform domains is proposed. For a given transform domains representation, a codebook is designed for each equal energy subband. The coder selects codes from the domain that best represents the signal vector. Sample results using one dimensional speech signals confirm the superior performance of the proposed MTSVQ scheme.
Fast exploration of bus-based communication architectures at the CCATB abstraction (2008)

Currently, system-on-chip (SoC) designs are becoming increasingly complex, with more and more components being integrated into a single SoC design. Communication between these components is increasingly dominating critical system paths and frequently becomes the source of performance bottlenecks. It, therefore, becomes imperative for designers to explore the communication space early in the design flow. Traditionally, system designers have used Pin-Accurate Bus Cycle Accurate (PA-BCA) models for early communication space exploration. These models capture all of the bus signals and strictly maintain cycle accuracy, which is useful for reliable performance exploration but results in slow simulation speeds for complex, designs, even when they are modeled using high-level languages. Recently, there have been several efforts to use the Transaction-Level Modeling (TLM) paradigm for improving simulation performance in BCA models. However, these transaction-based BCA (T-BCA) models capture a lot of details that can be eliminated when exploring communication architectures. In this paper, we extend the TLM approach and propose a new transaction-based modeling abstraction level (CCATB) to explore the communication design space. Our abstraction level bridges the gap between the TLM and BCA levels, and yields an average performance speedup of 120% over PA-BCA and 67% over T-BCA models, on average. The CCATB models are not only faster to simulate, but also extremely accurate and take less time to model compared to both T-BCA and PA-BCA models. We describe the mechanisms that produce the speedup in CCATB models and also analyze how the achieved simulation speedup scales with design complexity. To demonstrate the effectiveness of using CCATB for exploration, we present communication space exploration case studies from the broadband communication and multimedia application domains.
Radar Pulse Compression Repair (2007)

This correspondence presents an adaptive approach for range sidelobe mitigation for use by future radar systems as well as in-service radar systems in which the precompressed received signal may not be readily available or it may not be feasible to replace the current pulse compression system. The approach, denoted as pulse compression repair (PCR), utilizes a previously developed adaptive technique to operate on the match filtered output treating the resulting waveform autocorrelation as if it were the transmitted waveform thus "repairing" the effects of range-sidelobe masking that are induced by matched filtering. Illustrative results are presented comparing PCR with the matched filter and the CLEAN algorithm which demonstrate significant performance advantages for PCR as well as robustness to Doppler mismatch and system errors.
21‐3: Effect of Ag Adhesion Layer on Plasmon Outcoupling Efficiency (2022)

In this paper we explore energy loss in the novel plasmonic PHOLED device architecture that enables next‐generation OLED operation by harnessing energy previously believed to be trapped in the plasmon mode. We determine that the quality of Ag used in the plasmon out‐coupling scheme can increase the device efficiency by greater than 30%. We identify the Ag adhesion layer as a way to tune the quality of Ag and discuss the effects on both plasmon in‐ and out‐coupling efficiencies.
Microfabricated thick-film electrochemical sensor for nucleic acid determination (1996)

The utility of microfabricated thick-film sensors for single-use decentralized trace measurements of DNA and RNA was evaluated. Potentiometric stripping analysis (PSA) was employed to follow the oxidation of adsorbed nucleic acid species. The sensor performance is comparable to that of conventional/bulky carbon disc electrodes. Various parameters of the fabrication process and PSA operation were optimized to allow convenient monitoring of submicrograms per litre nucleic acid concentrations. The detection limits are 3, 25 and 30 µg l–1 for tRNA, ssDNA and dsDNA, respectively. The strong adsorption was also exploited for designing single-stranded nucleic acid-modified strips. The surface-bound probes were found to hybridize selectively with their complementary ssDNA or ssRNA. The hybridization was detected directly by changes in the guanine oxidation peak of the immobilized probe. The operation of the microfabricated nucleic acid sensors was coupled with a hand-held, easy-to-use battery-operated instrument, as desired for on-site DNA diagnostics.
Rapid High Temperature Solar Thermal Biomass Gasification in a Prototype Cavity Reactor (2009)

High temperature biomass gasification has been performed in a prototype concentrated solar reactor. Gasification of biomass at high temperatures has many advantages compared to historical methods of producing fuels. Enhancements in overall conversion, product composition ratios, and tar reduction are achievable at temperatures greater than 1000°C. Furthermore, the utilization of concentrated solar energy to drive these reactions eliminates the need to consume a portion of the product stream for heating and some of the solar energy is stored as chemical energy in the product stream. Experiments to determine the effects of temperature, gas flow rate, and feed type were conducted at the High Flux Solar Furnace (HFSF) at the National Renewable Energy Laboratory (NREL). These experiments were conducted in a reflective cavity multi-tube prototype reactor. Biomass type was found to be the only significant factor within a 95% confidence interval. Biomass conversion as high as 68% was achieved on sun. Construction and design considerations of the prototype reactor are discussed as well as initial performance results.
In Vitro Inhibition of <i>Toxoplasma gondii</i> by Four New Derivatives of Artemisinin (2006)

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.
Stagioni: Temperature management to enable near-sensor processing for energy-efficient high-fidelity imaging (2019)

Vision processing on traditional architectures is inefficient due to energy-expensive off-chip data movement. Many researchers advocate pushing processing close to the sensor to substantially reduce data movement. However, continuous near-sensor processing raises the sensor temperature, impairing the fidelity of imaging/vision tasks. We characterize the thermal implications of using 3D stacked image sensors with near-sensor vision processing units. Our characterization reveals that near-sensor processing reduces system power but degrades image quality. For reasonable image fidelity, the sensor temperature needs to stay below a threshold, situationally determined by application needs. Fortunately, our characterization also identifies opportunities -- unique to the needs of near-sensor processing -- to regulate temperature based on dynamic visual task requirements and rapidly increase capture quality on demand. Based on our characterization, we propose and investigate two thermal management strategies -- stop-capture-go and seasonal migration -- for imaging-aware thermal management. We present parameters that govern the policy decisions and explore the trade-offs between system power and policy overhead. Our evaluation shows that our novel dynamic thermal management strategies can unlock the energy-efficiency potential of near-sensor processing. For our evaluated tasks, our strategies save up to 53% of system power with negligible performance impact and sustained image fidelity.
Inventory-Service Optimization in Configure-to-Order Systems (2002)

This study is motivated by a process-reengineering problem in personal computer (PC) manufacturing, i.e., to move from a build-to-stock operation that is centered around end-product inventory towards a configure-to-order (CTO) operation that eliminates endproduct inventory. In fact, CTO has made irrelevant the notion of preconfigured machine types and focuses instead on maintaining the right amount of inventory at the components. CTO appears to be the ideal operational model that provides both mass customization and a quick response time to order fulfillment. To quantify the inventory-service trade-off in the CTO environment, we develop a nonlinear optimization model with multiple constraints, reflecting the service levels offered to different market segments. To solve the optimization problem, we develop an exact algorithm for the important case of demand in each market segment having (at least) one unique component, and a greedy heuristic for the general (nonunique component) case. Furthermore, we show how to use sensitivity analysis, along with simulation, to fine-tune the solutions. The performance of the model and the solution approach is examined by extensive numerical studies on realistic problem data. We present the major findings in applying our model to study the inventory-service impacts in the reengineering of a PC manufacturing process.
RF excitation in 7 tesla MRI systems using monofilar axial-mode helical antenna (2015)

We present a novel RF exciter for traveling-wave magnetic resonance imaging (MRI) systems based on a monofilar axial-mode helical antenna. In specific, we present a bore-extended, subject-loaded monofilar helical antenna for 7-T (ultra-high magnetic field) MRI systems. By means of rigorous full-wave electromagnetic modeling, we confirm clear advantages of the novel exciter over the existing TW excitation methods, and its excellent performance in terms of circular polarization and uniformity of the RF magnetic field in simple phantoms inside MRI bores at 7 T.
Effects of modified air quenches on the high‐speed melt spinning process (1991)

Abstract A high molecular weight polyethylene terephthalate was spun into fibers in the speed range from 3,000–7,000 mpm. The effect of modifying threadline dynamics through a combination of enhanced and/or retarding air quenches on the resulting spinning performance, fiber structure, and mechanical properties was examined. Particular combinations of these threadline temperature profile modifications were shown to result in significant improvements in spinning performance and as‐spun fiber structure. Extensive characterization of select fiber samples revealed higher orientation and crystallinity, larger crystal dimensions, and greater mechanical properties. These results also demonstrated the ability to provide continued improvement in fiber properties at very high take‐up speeds where typically a decline is observed. It is concluded that the threadline temperature profile can be altered in such a way as to significantly enhance the resulting spinning performance and fiber structure over a wide range of take‐up speeds.
Noise Immune, Low-Skew, Pulse Width Retainable Analog Glitch-Filter (2019)

Slow, noise-prone IC interfaces such as I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> C and SPI require input buffers with a glitch filter circuit to suppress input spikes of a given pulse width. This glitch filter is conventionally implemented as an analog RC circuit whose resistor and capacitor values are chosen according to the pulse width to be suppressed. Such a topology suffers from duty cycle distortion, pulse clipping and supply noise susceptibility - issues that could produce both functional as well as critical timing failures at system level. Our work addresses these issues by proposing an analog glitch filter that employs a combination of feed-back and feed-forward circuit elements, with minimal area overhead with respect to conventional schemes.
New trends and limits in plasma etching (1987)

Dry etching technology appears as the key for microelectronics processes. This paper presents some new trends and limits in current plasma etching. Plasma etching can be used to delineate patterned structures or to transfer a smooth planar surface to the circuit. Typical results and limits are given concerning the etching rate, the consumption of the underlayer, the pattern-sizes control (in particular for the case of a bilayer structure) and the surface quality. Some aspects of a planar and a smooth process are also presented.
Solid state p-n heterojunction sensitized photovoltaic solar cell with electron and hole conductors (2002)

A solid state p-n heterojunction comprising an electron conductor and a hole conductor; it further comprises a sensitising semiconductor, said sensitizing semiconductor being located at an interface between said electron conductor and said hole conductor. In particular, the sensitizing semiconductor is in form of quantum-dots. A solid state sensitized photovoltaic cell comprises such a layered heterojunction between two electrodes. <IMAGE>
<title>Grisms: novel dispersive devices for the manipulation of femtosecond pulses</title> (1996)

We show that a pair of grisms (transmission gratings written onto prisms) exhibits second- and third-order dispersion opposite to that of an optical fiber. Using a fiber stretcher and a grism- pair compressor, we demonstrate chirped-pulse amplification and transform-limited compression of 135-fs pulses. This scheme can be used to produce 50-fs, microjoule pulses in a compact and simple system.