gebhart/patrepeval huggingface dataset:
MEMS Capacitive Accelerometer-Based Middle Ear Microphone (2012)

The design, implementation, and characterization of a microelectromechanical systems (MEMS) capacitive accelerometer-based middle ear microphone are presented in this paper. The microphone is intended for middle ear hearing aids as well as future fully implantable cochlear prosthesis. Human temporal bones acoustic response characterization results are used to derive the accelerometer design requirements. The prototype accelerometer is fabricated in a commercial silicon-on-insulator (SOI) MEMS process. The sensor occupies a sensing area of 1 mm × 1 mm with a chip area of 2 mm × 2.4 mm and is interfaced with a custom-designed low-noise electronic IC chip over a flexible substrate. The packaged sensor unit occupies an area of 2.5 mm × 6.2 mm with a weight of 25 mg. The sensor unit attached to umbo can detect a sound pressure level (SPL) of 60 dB at 500 Hz, 35 dB at 2 kHz, and 57 dB at 8 kHz. An improved sound detection limit of 34-dB SPL at 150 Hz and 24-dB SPL at 500 Hz can be expected by employing start-of-the-art MEMS fabrication technology, which results in an articulation index of approximately 0.76. Further micro/nanofabrication technology advancement is needed to enhance the microphone sensitivity for improved understanding of normal conversational speech.
A scalable algorithm for image retrieval by color (2002)

To deal with large databases, we present a clustering based indexing technique, where the images in the database are grouped into clusters of images with similar color content using a hierarchical clustering algorithm. At search time, the query image is not compared with all the images in the database, but only with a small subset. Thus the retrieval is scalable to large databases. Experiments show that this clustering based approach offers a superior response time without sacrificing the retrieval accuracy, which is crucial for large databases.
Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. (1991)

Two phenotypic parameters, aberrant expression of protein kinase C and tumor cell-induced platelet aggregation (PA), have been correlated with abnormal growth behavior and metastatic potential of tumor cells. We recently observed that N,N,N-trimethylsphingosine (TMS) and N,N-dimethylsphingosine (DMS), but not sphingosine (SPN), had an inhibitory effect (via blocking of transmembrane signaling) on the growth of various human tumor cell lines in vitro as well as in vivo in nu/nu mice (K. Endo et al., Cancer Res., 51: 1613-1618, 1991). We therefore investigated the effects of TMS, DMS, and SPN on (a) PA induced by ADP and thrombin; (b) PA induced by melanoma cell line B16/BL6; and (c) experimental lung colonization as well as spontaneous lung metastasis of BL6 cells in syngeneic C57BL/6 mice. In experiments on agonist-induced PA, TMS inhibited PA and ATP secretion 5-fold more strongly than DMS or SPN. This effect may be based on the inhibition of Mr 47,000 platelet protein phosphorylation and/or inhibition of phosphatidylinositol turnover as a transmembrane signaling pathway in platelets. Tumor cell (BL6 melanoma)-induced PA and ATP secretion were also strongly inhibited by TMS, but not by DMS or SPN. Unlike ADP- or thrombin-induced PA, BL6 cell-induced PA was not inhibited by Calphostin-C (a potent protein kinase C inhibitor) or cilostazol (a potent inhibitor of PA based on inhibition of cyclic AMP phosphodiesterase). Since many previous studies suggested that the ability of tumor cells to induce PA is related to the degree of malignancy (e.g., metastatic potential) of tumor cells, we studied the effect of TMS on lung metastatic potential. Three independent sets of experiments, as described below, all showed clear inhibition of lung metastasis by administration of TMS: (a) i.v. coinjection of BL6 melanoma cells and TMS; (b) i.v. injection of TMS and, 1 h later, BL6 cells; (c) spontaneous metastasis to lung from s.c. BL6 tumor (TMS administered after establishment of tumor, followed by resection of tumor). In comparison to tumor growth inhibition produced by TMS or DMS, inhibition of melanoma metastasis by TMS is obvious at lower doses.
Synthesis Of Perfluoro Orthocarbonates (1994)

Perfluoro tetraalkyl orthocarbonates and perfluoro dialkyl acetals synthesized by direct fluorination of orthocarbonates and polyalkoxy propanes. Perfluoro compounds more volatile than perfluoropolyethers having same molecular weights and stable at temperatures up to at least 150 degrees C. Useful as heat-exchange fluids, lubricants, and/or vapor-phase soldering fluids.
Incremental evaluation of schema-directed XML publishing (2004)

When large XML documents published from a database are maintained externally, it is inefficient to repeatedly recompute them when the database is updated. Vastly preferable is incremental update, as common for views stored in a data warehouse. However, to support schema-directed publishing, there may be no simple query that defines the mapping from the database to the external document. To meet the need for efficient incremental update, this paper studies two approaches for incremental evaluation of ATGs [4], a formalism for schema-directed XML publishing. The reduction approach seeks to push as much work as possible to the underlying DBMS. It is based on a relational encoding of XML trees and a nontrivial translation of ATGs to SQL 99 queries with recursion. However, a weakness of this approach is that it relies on high-end DBMS features rather than the lowest common denominator. In contrast, the bud-cut approach pushes only simple queries to the DBNS and performs the bulk of the work in middleware. It capitalizes on the tree-structure of XML views to minimize unnecessary recomputations and leverages optimization techniques developed for XML publishing. While implementation of the reduction approach is not yet in the reach of commercial DBMS, we have implemented the bud-cut approach and experimentally evaluated its performance compared to recomputation.
Introduction of Architecturally Visible Storage in Instruction Set Extensions (2007)

Instruction set extensions (ISEs) can be used effectively to accelerate the performance of embedded processors. The critical and difficult task of ISE selection is often performed manually by designers. A few automatic methods for ISE generation have shown good capabilities but are still limited in the handling of memory accesses, and so they fail to directly address the memory wall problem. We present here the first ISE identification technique that can automatically identify state-holding application-specific functional units (AFUs) comprehensively, thus being able to eliminate a large portion of memory traffic from cache and the main memory. Our cycle-accurate results obtained by the SimpleScalar simulator show that the identified AFUs with architecturally visible storage gain significantly more than previous techniques and achieve an average speedup of 2.8times over pure software execution with a little area overhead. Moreover, the number of required memory-access instructions is reduced by two thirds on average, suggesting corresponding benefits on energy consumption
Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(<scp>iii</scp>) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines (2014)

Promising cytotoxic gold(<sc>iii</sc>) complexes with general formula [Au{(1,2-DACH)}<sub>2</sub>]Cl<sub>3</sub> are reported.
Common-Mode Voltage Reduction PWM Algorithm for AC Drives (2010)

The impact of common-mode voltage (CMV) generated by pulsewidth modulation (PWM) ac drives on motor bearings is well known. Several algorithms for CMV reduction have been proposed in the literature. While a few algorithms assume ideal switching and fall apart when nonidealities like inverter dead time are considered, some others are effective only in a limited operating range of the drive. In this paper, a previously proposed algorithm is modified for practical implementation to include compensation for dead-time and reflected-wave motor overvoltage stress while still producing output voltage waveforms with reduced common-mode content. Experimental results are provided to show the reduction in CMV over the entire operating range, with other performance attributes such as reflected-wave motor overvoltage that are identical to conventional space-vector PWM. The advantages of applying the algorithm to a fully regenerative ac drive are also demonstrated.
Deep brain transcranial magnetic stimulation using variable “Halo coil” system (2015)

Transcranial Magnetic Stimulation has the potential to treat various neurological disorders non-invasively and safely. The “Halo coil” configuration can stimulate deeper regions of the brain with lower surface to deep-brain field ratio compared to other coil configurations. The existing “Halo coil” configuration is fixed and is limited in varying the site of stimulation in the brain. We have developed a new system based on the current “Halo coil” design along with a graphical user interface system that enables the larger coil to rotate along the transverse plane. The new system can also enable vertical movement of larger coil. Thus, this adjustable “Halo coil” configuration can stimulate different regions of the brain by adjusting the position and orientation of the larger coil on the head. We have calculated magnetic and electric fields inside a MRI-derived heterogeneous head model for various positions and orientations of the coil. We have also investigated the mechanical and thermal stability of the adjustable “Halo coil” configuration for various positions and orientations of the coil to ensure safe operation of the system.
A Gabor feature fusion framework for hyperspectral imagery classification (2017)

Hyperspectral imagery acquired by a hyperspectral sensor contains hundreds of narrow contiguous spectral bands, providing the opportunity to identify the various materials present on the surface. Due to the three-dimensional (3D) nature of hyperspectral data, 3D filters that could extract joint spatial-spectral features have been recently considered in the literature. In this paper, after the 3D Gabor features with certain orientations have been extracted from the raw hyperspectral image data, both the Gabor magnitude and phase features have been used for hyperspectral imagery classification, which is named as Gabor-MP. Specifically, the confidence score of each test sample is computed by support vector machine for each Gabor magnitude feature cube, while the Hamming distance is calculated based on the quadrant bit coding of each Gabor phase feature cube. Then the label of the test sample is identified by simple calculation between the confidence scores and Hamming distance values. Experimental results on two real hyperspectral data have demonstrated the effectiveness of the proposed Gabor feature fusion framework for hyperspectral imagery classification.
Real-Time Deposition Monitor for Ultrathin Conductive Films (2011)

A device has been developed that can be used for the real-time monitoring of ultrathin (2 or more) conductive films. The device responds in less than two microseconds, and can be used to monitor film depositions up to about 60 thick. Actual thickness monitoring capability will vary based on properties of the film being deposited. This is a single-use device, which, due to the very low device cost, can be disposable. Conventional quartz/crystal microbalance devices have proven inadequate to monitor the thickness of Pd films during deposition of ultrathin films for hydrogen sensor devices. When the deposited film is less than 100 , the QCM measurements are inadequate to allow monitoring of the ultrathin films being developed. Thus, an improved, high-sensitivity, real-time deposition monitor was needed to continue Pd film deposition development. The new deposition monitor utilizes a surface acoustic wave (SAW) device in a differential delay-line configuration to produce both a reference response and a response for the portion of the device on which the film is being deposited. Both responses are monitored simultaneously during deposition. The reference response remains unchanged, while the attenuation of the sensing path (where the film is being deposited) varies as the film thickness increases. This device utilizes the fact that on high-coupling piezoelectric substrates, the attenuation of an SAW undergoes a transition from low to very high, and back to low as the conductivity of a film on the device surface goes from nonconductive to highly conductive. Thus, the sensing path response starts with a low insertion loss, and as a conductive film is deposited, the film conductivity increases, causing the device insertion loss to increase dramatically (by up to 80 dB or more), and then with continued film thickness increases (and the corresponding conductivity increases), the device insertion loss goes back down to the low level at which it started. This provides a continuous, real-time monitoring of film deposition. For use with different films, the device would need to be calibrated to provide an understanding of how film thickness is related to film conductivity, as the device is responding primarily to conductivity effects (and not to mass loading effects) in this ultrathin film regime.
Statistical image reconstruction for polyenergetic X-ray computed tomography (2002)

This paper describes a statistical image reconstruction method for X-ray computed tomography (CT) that is based on a physical model that accounts for the polyenergetic X-ray source spectrum and the measurement nonlinearities caused by energy-dependent attenuation. We assume that the object consists of a given number of nonoverlapping materials, such as soft tissue and bone. The attenuation coefficient of each voxel is the product of its unknown density and a known energy-dependent mass attenuation coefficient. We formulate a penalized-likelihood function for this polyenergetic model and develop an ordered-subsets iterative algorithm for estimating the unknown densities in each voxel. The algorithm monotonically decreases the cost function at each iteration when one subset is used. Applying this method to simulated X-ray CT measurements of objects containing both bone and soft tissue yields images with significantly reduced beam hardening artifacts.
External cavity beam combining of 21 semiconductor lasers using SPGD (2012)

Active coherent beam combining of laser oscillators is an attractive way to achieve high output power in a diffraction limited beam. Here we describe an active beam combining system used to coherently combine 21 semiconductor laser elements with an 81% beam combining efficiency in an external cavity configuration compared with an upper limit of 90% efficiency in the particular configuration of the experiment. Our beam combining system utilizes a stochastic parallel gradient descent (SPGD) algorithm for active phase control. This work demonstrates that active beam combining is not subject to the scaling limits imposed on passive-phasing systems.
A cell-free platform for the prenylation of natural products and application to cannabinoid production (2019)

Prenylation of natural compounds adds structural diversity, alters biological activity, and enhances therapeutic potential. Because prenylated compounds often have a low natural abundance, alternative production methods are needed. Metabolic engineering enables natural product biosynthesis from inexpensive biomass, but is limited by the complexity of secondary metabolite pathways, intermediate and product toxicities, and substrate accessibility. Alternatively, enzyme catalyzed prenyl transfer provides excellent regio- and stereo-specificity, but requires expensive isoprenyl pyrophosphate substrates. Here we develop a flexible cell-free enzymatic prenylating system that generates isoprenyl pyrophosphate substrates from glucose to prenylate an array of natural products. The system provides an efficient route to cannabinoid precursors cannabigerolic acid (CBGA) and cannabigerovarinic acid (CBGVA) at >1 g/L, and a single enzymatic step converts the precursors into cannabidiolic acid (CBDA) and cannabidivarinic acid (CBDVA). Cell-free methods may provide a powerful alternative to metabolic engineering for chemicals that are hard to produce in living organisms.
Stateless Forwarding in ICN with Dynamic Non-Bloom Filters (2019)

In this paper, we propose a novel packet forwarding architecture for information centric networking (ICN) towards achieving resource efficient and scalable content delivery using ICN principles. Proposed solution addresses one of the main challenges for ICN, by focusing on the limitations of stateful forwarding; which is utilized by content-centric networking (CCN) based ICN architectures at the ICN-enabled content routers to provide breadcrumbs for content objects to follow by creating forwarding states for their requests along the path towards the content source. Due to increased storage requirements associated with stateful forwarding, it can potentially lead to inefficient packet forwarding to prevent routers from forwarding at line-rate speeds. Existing solutions focused on using Bloom filter (BF) based designs to achieve stateless forwarding, however, at the cost of false positives. Unlike these earlier works, our solution addresses this problem by proposing a dynamic BF-less scheme to not only address the stateful forwarding objectives but also to limit problems associated with the existing stateless forwarding designs that rely on BFs. Through a simulation-based study, we observed significant 5-20 times improvement in transmission overhead with the proposed solution when compared to BF-based stateless forwarding, while offering a more processing-friendly design.
Purification of the messenger RNA cap-binding protein using a new affinity medium (1984)

The p-aminophenyl gamma-ester of 7-methylguanosine 5'-triphosphate (m7GTP) was synthesized and coupled to Sepharose 4B. A 0.5 M salt extract of rabbit reticulocyte ribosomes was passed over a column containing the affinity medium. After extensive washing, a solution of m7GTP was passed through the column, and a single polypeptide species of 24 kilodaltons (kDa) was eluted. This had an electrophoretic mobility identical with that of the mRNA cap-binding protein. This assignment was confirmed by the fact that the eluted material was enriched nearly 200-fold in the ability to specifically bind 32P-labeled capped oligonucleotides. A control affinity medium consisting of GTP similarly coupled to Sepharose failed to retain the 24-kDa species. The postribosomal supernatant fraction yielded slightly more of the 24-kDa species than the ribosomal wash fraction when passed over this affinity medium.
A Multigrid Fluid Pressure Solver Handling Separating Solid Boundary Conditions (2012)

We present a multigrid method for solving the linear complementarity problem (LCP) resulting from discretizing the Poisson equation subject to separating solid boundary conditions in an Eulerian liquid simulation’s pressure projection step. The method requires only a few small changes to a multigrid solver for linear systems. Our generalized solver is fast enough to handle 3D liquid simulations with separating boundary conditions in practical domain sizes. Previous methods could only handle relatively small 2D domains in reasonable time, because they used expensive quadratic programming (QP) solvers. We demonstrate our technique in several practical scenarios, including nonaxis-aligned containers and moving solids in which the omission of separating boundary conditions results in disturbing artifacts of liquid sticking to solids. Our measurements show, that the convergence rate of our LCP solver is close to that of a standard multigrid solver.
Overview of Spatial Processing Approaches for GNSS Structural Interference Detection and Mitigation (2016)

GNSS-dependent positioning, navigation, and timing synchronization procedures have a significant impact on everyday life. Thus, such an extensively used system progressively become an attractive target for illegal exploitation and attacks. Position and timing solutions provided by GNSS receivers can be threatened by structural interference such as spoofing threats. This paper provides an overview of recent research work on GNSS signal authentication utilizing spatial processing methods. Different spatial processing approaches for spoofing detection, classification and mitigation are characterized and compared. Three different processing methods, namely antenna array processing, moving receiver and cloud based spoofing countermeasure are analyzed in details. The benefits and disadvantages of each are discussed.
A Convenient Route to Tetraalkylammonium Perfluoroalkoxides from Hydrofluoroethers (2015)

Hydrofluoroethers are shown to alkylate tertiary amines readily under solvent-free conditions, affording valuable tetraalkylammonium perfluoroalkoxides bearing α-fluorines. The reaction of R(F)CF2-OCH3 (R(F)=CF2CF3, CF2CF2CF3, and CF(CF3)2) with NR(1)R(2)R(3) produces twenty new α-perfluoroalkoxides, [(CH3)NR(1)R(2)R(3)][R(F)CF2O] under mild conditions. These α-perfluoroalkoxides are easy to handle, thermally stable, and can be used for the perfluoroalkoxylation of benzyl bromides.
The Production of Titanium Alloy Powder (2013)

Titanium alloy powder provides manufacturing variants to produce a variety of titanium intermediate materials and final products. However, titanium alloy powder is quite expensive at fifteen to thirty times the cost of sponge thus limiting the utilization of titanium powder to produce titanium products. The standard state-of-the-art processing to produce alloy powder results in very high cost of alloy powder. Three new processes have been demonstrated to produce titanium alloy powder at a cost of only 2-5 times the typical cost of sponge. The processes are (1) one step melting of sponge/alloying and gas blowing alloy powder, (2) metallothermic reduction of mixed chloride precursors to produce alloy powder and (3) electrolytic reduction in a fused salt of mixed alloying (TiCl 4 -AlCl 3 -VCl4) chlorides. These processes have bee Subscript text n demonstrated to produce low cost titanium alloy powder which can serve as feeds for the variant manufacturing processes to produce low cost titanium products.