gebhart/patrepeval huggingface dataset:
A major factor VIII binding domain resides within the amino-terminal 272 amino acid residues of von Willebrand factor. (1987)

We have identified a Factor VIII (FVIII) binding domain residing within the amino-terminal 272 amino acid residues of the mature von Willebrand Factor (vWF) subunit. Two-dimensional crossed immunoelectrophoresis showed direct binding of purified human FVIII to purified human vWF. After proteolytic digestion of vWF with Staphylococcus aureus V8 protease (SP), FVIII binding was seen only with the amino-terminal SP fragment III and not with the carboxyl-terminal SP fragment II. A monoclonal anti-vWF antibody (C3) partially blocked FVIII binding to vWF and SP fragment III. FVIII also bound to vWF which had been adsorbed to polystyrene beads. This binding was inhibited in a dose-dependent manner by whole vWF, SP fragment III, and by monoclonal antibody C3. Binding could not be inhibited by SP fragment I, which contains the middle portion of the vWF molecule, or by reduced and alkylated whole vWF. SP fragment II caused only minimal inhibition. Trypsin cleavage of SP fragment III produced a monomeric 35-kDa fragment containing the amino-terminal 272 amino acid residues of vWF. This fragment reacted with monoclonal antibody C3 and inhibited the binding of FVIII to vWF in a dose-dependent manner. These studies demonstrate that a major FVIII binding site resides within the amino-terminal 272 amino acid residues of vWF.
A Hyperactive Signalosome Results in High Sensitivity to HSP90 Inhibitors in AML (2015)

Abstract HSP90 is well established in supporting tumorigenesis by stabilizing oncogenic client proteins. Given this crucial role, a number of HSP90 inhibitors have been tested in various types of cancer, including leukemia. However, clinical trials thus far revealed only a subset of AML patients benefited from the treatment. Therefore, precision medicine approaches to define parameters that predict the patients' response to HSP90 inhibitors are needed to select patients who are most likely to benefit. We have previously demonstrated that PU-H71, a novel purine scaffold HSP90 inhibitor with selectivity for a tumor-specific HSP90 and currently translating into Phase 2 clinical evaluation, is capable of ablating malignant blasts, progenitor and stem cells in AML patient samples using in vitro studies. We found that leukemia cell lines (n=18) and primary AML patient samples (n=26) with greater numbers of simultaneously activated signaling networks, including PI3K-AKT and JAK-STAT, were the most sensitive to HSP90 inhibition. Using different genetic models, our studies revealed that diverse oncogenic transformations that converge upon simultaneous hyperactivation of PI3K-AKT and JAK-STAT promote sensitivity to PU-H71. To validate the efficacy of PU-H71 in vivo, we generated AML-GFP-luciferase xenograft models using cell lines with hyperactive signalosome. Xenotransplanted mice were treated with PU-H71 one week post-engraftment. In vivo imaging indicated that MOLM-13 xenografted leukemia was rapidly and significantly reduced by PU-H71 treatment. Six doses of PU-H71 produced robust anti-leukemic activity as indicated by in vivo imaging and flow cytometric analysis of post-treatment bone marrow (no disease detected). In addition, we generated 7 AML patient-derived xenografts (PDX) cohorts with samples that displayed varied levels of activation of PI3K-AKT and JAK-STAT signaling pathways. After initial validation that status of the PI3K-AKT and JAK-STAT signaling pathways were preserved in the PDX, we initiated treatment with PU-H71 and found that, as predicted, the AML-PDX with the most hyperactive signalosome were the most sensitive to in vivo treatment to PU-H71. Importantly, samples with hyperactive PI3K-AKT and JAK-STAT signaling also demonstrated a significant reduction in LSC using secondary transplants. Taken together, we found that a hyperactive signalosome results in increased sensitivity to the HSP90 inhibitor PU-H71 in vitro and in vivo. Our study suggests that evaluation of PI3K-AKT and JAK-STAT signaling pathways may provide a means to select patients who are most likely to benefit from HSP90 inhibitory therapy. Disclosures No relevant conflicts of interest to declare.
Rivulet (2017)

Rivulet is a fault-tolerant distributed platform for running smart-home applications; it can tolerate failures typical for a home environment (e.g., link losses, network partitions, sensor failures, and device crashes). In contrast to existing cloud-centric solutions, which rely exclusively on a home gateway device, Rivulet leverages redundant smart consumer appliances (e.g., TVs, Refrigerators) to spread sensing and actuation across devices local to the home, and avoids making the Smart-Home Hub a single point of failure. Rivulet ensures event delivery in the presence of link loss, network partitions and other failures in the home, to enable applications with reliable sensing in the case of sensor failures, and event processing in the presence of device crashes. In this paper, we present the design and implementation of Rivulet, and evaluate its effective handling of failures in a smart home.
Fisher vectors meet Neural Networks: A hybrid classification architecture (2015)

Fisher Vectors (FV) and Convolutional Neural Networks (CNN) are two image classification pipelines with different strengths. While CNNs have shown superior accuracy on a number of classification tasks, FV classifiers are typically less costly to train and evaluate. We propose a hybrid architecture that combines their strengths: the first unsupervised layers rely on the FV while the subsequent fully-connected supervised layers are trained with back-propagation. We show experimentally that this hybrid architecture significantly outperforms standard FV systems without incurring the high cost that comes with CNNs. We also derive competitive mid-level features from our architecture that are readily applicable to other class sets and even to new tasks.
Supervised relevance neural gas and unified maximum separability analysis for classification of mass spectrometric data (2005)

The paper deals with the application of the novel generalized relevance learning vector quantization based classification algorithm in comparison to the unified maximum separability analysis as a special variant of support vector machine algorithms. The algorithms are compared and their performance on real life data, taken from clinical studies, is demonstrated. It is shown that the vector quantization classifier gives competitive results in comparison to the considered support vector machine algorithm and shows the recently theoretical proven equivalence in classification capability of both paradigms.
Ultrasensitive On-Chip Photonic Crystal Nanobeam Sensor using Optical Bistability (2011)

An ultrasensitive nonlinear cavity sensing method is proposed and demonstrated, in which the detection limit is not bounded by the quality factor of the cavity. 10mg/dL glucose concentration and 100aM BSA molecules are detected.
Computerized detection and characterization of mass lesions in digital mammography (2003)

Computer-aided diagnosis schemes for the detection of breast lesions in digital mammograms are being developed. The detection scheme employs a bilateral-subtraction technique that is based on the normal symmetry between the left and right breast images. The presence of asymmetries indicates a possible lesion. Feature-analysis techniques are then used to reduce the number of false-positive detections. In addition, characterization methods are being developed to aid in the benign/malignant decision. The authors plan to incorporate the schemes into a dedicated intelligent workstation for use as a second opinion in a mammographic screening program. Output from the computer would be displayed as an aid, leaving the final diagnostic decision to the radiologist.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Progress with Closed-loop Systems in Type 1 Diabetes (2010)

Automated insulin delivery by means of a glucose-responsive closed-loop system has often been cited as the ‘holy grail’ of type 1 diabetes management. Reflecting the technological advances in interstitial glucose measurements and wider use of continuous glucose monitoring, recent research in closed-loop glucose control has focused on the subcutaneous route for glucose measurements and insulin delivery. The primary aim of such systems is to keep blood glucose within the target range while minimising the risk of hypoglycaemia with minimal input from the user. This article examines recent developments in the field of interstitial glucose measurement, limitations of the current generation of devices and implications on the performance of closed-loop systems. Clinical results and the advantages and disadvantages of different closed-loop configurations are summarised. Potential future advances in closed-loop systems are highlighted.
Modeling and estimation of Nickel Metal Hydride battery hysteresis for SOC estimation (2008)

Accurate estimation of battery state of charge (SOC) is essential for battery control and effective energy management of hybrid electric vehicles (HEV). Battery hysteresis poses a big challenge to the estimation of SOC. In the present battery state estimator (BSE), a rule-based hysteresis estimation method for nickel metal hydride (NiMH) batteries is used due to the lack of physical hysteresis models. The rule-based hysteresis estimation method gives only a coarse result with limited accuracy. To improve estimation accuracy and algorithm robustness, a new on-board algorithm, based on the Preisach operator, is developed to estimate battery hysteresis. The enhanced model-based algorithm is then integrated into the BSE algorithms for evaluation. Simulation and preliminary evaluation results for NiMH batteries show significant improvement in the accuracy and robustness of SOC estimation.
Catalytic multi-stage liquefaction of coal. Ninth quarterly report, October 1, 1994--December 31, 1994 (1995)

This quarterly report covers the activities of Catalytic Multi-Stage Liquefaction of Coal during the Period October 1 - December 31, 1994, at Hydrocarbon Research, Inc. in Lawrenceville and Princeton, New Jersey. This DOE Contract Period was from December 8, 1992 to December 7, 1994 and has been extended to September 30, 1995. The overall objective of this program is to produce liquid fuels from coal by direct liquefaction at a cost that is competitive with conventional fuels. Specifically, this continuous bench-scale program contains provisions to examine new ideas in areas such as: low temperature pretreatments, more effective catalysts, on-line hydrotreating, new coal feedstocks, other hydrogen sources, more concentrated coal feeds and other highly responsive process improvements while assessing the design and economics of the bench-scale results. This quarterly report covers work on Laboratory Scale Studies, Continuous Bench-Scale Operations, Technical Assessment and Project Management.
Human cancer cell line microRNAs associated with in vitro sensitivity to paclitaxel (2013)

Paclitaxel is a mainstay of treatment for many solid tumors, and frequently, clinical outcome is influenced by paclitaxel sensitivity. Despite this, our understanding of the molecular basis of paclitaxel response is incomplete. Recently, it has been shown that microRNAs (miRNAs) influence messenger RNA (mRNA) transcriptional control and can contribute to human carcinogenesis. In the present study, our objective was to identify miRNAs associated with cancer cell line response to paclitaxel and to evaluate these miRNAs as therapeutic targets to increase paclitaxel sensitivity. We measured the expression of 335 unique miRNAs in 40 human cancer cell lines selected from the NCI panel. We then integrated miRNA expression data with publicly available paclitaxel-sensitivity (GI₅₀) data for each of the 40 cell lines to identify miRNAs associated with paclitaxel sensitivity. Ovarian cancer cell lines with differential miRNA expression and paclitaxel sensitivity were transiently transfected with miRNA precursors and inhibitors, and the effects on in vitro cell paclitaxel sensitivity were evaluated. Pearson's correlation identified 2 miRNAs (miR-367 and miR-30a-5p) associated with the NCI40 cell line in vitro paclitaxel response (P<0.0003). Ovarian cancer cells were selected based on the association between paclitaxel sensitivity and miR-367/miR-30a-5p expression. Overexpression of miR-367 in the paclitaxel-sensitive cells [PA1; IC₅₀, 1.69 nM, high miR-367 (2.997), low miR-30a-5p (-0.323)] further increased paclitaxel sensitivity, whereas miR-367 depletion decreased paclitaxel sensitivity. In contrast, overexpression and depletion of miR-30a-5p in the paclitaxel-resistant cells [OVCAR4; IC₅₀, 17.8 nM, low miR-367 (-0.640), high miR-30a-5p (3.270)] decreased and increased paclitaxel sensitivity, respectively. We identified and successfully targeted miRNAs associated with human cancer cell line response to paclitaxel. Our strategy of integrating in vitro miRNA expression and drug sensitivity data may not only aid in the characterization of determinants of drug response but also in the identification of novel therapeutic targets to increase activity of existing therapeutics.
A prolonged discharge time ESD power-rail clamp circuit structure with strong ability to prevent false triggering (2016)

A new reliable Electrostatic Discharge (ESD) power-rail clamp circuit has been proposed in this paper. The new circuit structure has achieved good results in reducing leakage current, anti-false triggering, increasing discharge transistor's turn on time. During the ESD event, the proposed circuit has a discharge time of 755.22ns, which is about 6.74 times that of conventional R-C power-rail clamp circuit. Besides, the leakage current of whole circuit eventually stabilizes at a lower level of 46.50nA.
3210 A Proposal of MUB (Meshing Under Base-circle) Theory for Worm Wheel Installed in EPS (2011)

We have been investigating small and high-strengthened single threaded worm gear. Previous our studies have shown that reducing thickness of worm tooth on addendum face enlarges elastic deformation of worm wheel. This proposed profile has advantages on improving contact ratio, gear efficiency, strength against impact force and fluctuation in torque. Though we have modified the profile of worm, we have not reported on a profile of worm wheel. In this paper, we propose the MUB theory that new profile of worm wheel improve contact ratio without increasing tip diameter of worm wheel. At first, we focused on meshing under base circle of worm wheel, and investigated geometrical shape on dedendum face manufactured by hob cutter. As a result, we derived formula of new profile of worm wheel for meshing under base circle. In addition, the MUB theory was verified by the experiment that used an actual worm wheel with MUB profile. It was shown that we obtained a new finding by the process of this research.
Complete Suppression of Color Shift in In-plane Switching Mode Liquid Crystal Displays with a Multidomain Structure Obtained by Unidirectional Rubbing (1997)

Complete suppression of color shift in in-plane switching mode liquid crystal displays (LCDs) has been realized. The LCDs have a multidomain structure obtained by unidirectional rubbing and use of zigzag electrodes. The design concept and performance of the devices are described in this paper.
Fabrication of highly electrically conducting fine patterns via substrate-independent inkjet printing of mussel-inspired organic nano-material (2014)

We report the inkjet printing of an aqueous suspension of synthesized mussel-inspired poly(dopamine) nanoparticles and the subsequent site-selective silver electroless plating process.
Feasibility of field-based light scattering spectroscopy (2000)

Light scattering spectroscopy (LSS) is a new technique capable of accurately measuring the features of nuclei and other cellular organelles in situ. We present the considerations required to implement and interpret field-based detection in LSS, where the scattered electric field is detected interferometrically, and demonstrate that the technique is experimentally feasible. A theoretical formalism for modeling field-based LSS signals based on Mie scattering is presented. Phase-front uniformity is shown to play an important and novel role. Results of heterodyne experiments with polystyrene microspheres that localize LSS signals to a region about 30 microns in axial extent are reported. In addition, differences between field-based LSS and the earlier intensity-based LSS are discussed.
Toward online multi‐period power dispatch with AC constraints and renewable energy (2018)

In this study, a comprehensive online multi‐period power dispatch formulation that takes AC constraints, renewable energy, and ramping constraints into account is proposed. The AC power flow equations, voltage limits, and thermal limits are respected to ensure the obtained solution causes no static violation while guaranteeing transfer capability. A four‐stage solution methodology is proposed to solve the non‐linear constrained optimisation problem in which the thermal limit constraints are equivalently represented by active‐set‐based constraints in the third stage, and an adaptive homotopy‐enhanced primal‐dual interior point method (PDIPM) in solving power dispatch problem is presented in the fourth stage to reliably and efficiently obtain the solution. This solution methodology enhances both the robustness and speed of the PDIPM. The proposed four‐stage solution methodology has been evaluated on several testing systems, ranging from a 30‐bus system to a 3012‐bus system with four time periods, with promising results.
Heavy-duty sandblast nozzle (1977)

Inexpensive sialon (silicon/aluminum/oxygen/nitrogen) nozzle liner resists abrasion and is strong at high temperatures.
A new statistical setup and hold time definition (2012)

Process variability becomes prominent for circuits using nanometer manufacturing technology. With aggressive voltage scaling, unexpected failures occur due to excessive timing variation. Yield, number of components, and process variability are intrinsically linked. In this paper, we study the setup and hold time definition, margin, and characterization methodology. A new statistical margin quantifying methodology, setup and hold time definition and characterization methodology are proposed.
MixApart: decoupled analytics for shared storage systems (2013)

Distributed file systems built for data analytics and enterprise storage systems have very different functionality requirements. For this reason, enabling analytics on enterprise data commonly introduces a separate analytics storage silo. This generates additional costs, and inefficiencies in data management, e.g., whenever data needs to be archived, copied, or migrated across silos.MixApart uses an integrated data caching and scheduling solution to allow MapReduce computations to analyze data stored on enterprise storage systems. The front-end caching layer enables the local storage performance required by data analytics. The shared storage back-end simplifies data management.We evaluate MixApart using a 100-core Amazon EC2 cluster with micro-benchmarks and production workload traces. Our evaluation shows that MixApart provides (i) up to 28% faster performance than the traditional ingest-then-compute workflows used in enterprise IT analytics, and (ii) comparable performance to an ideal Hadoop setup without data ingest, at similar cluster sizes.
First experimental results of an HNF/Al/GAP solid rocket propellant (1997)

1. Abstract This paper deals with performance test results of a new solid composite propellant based on GAP and Hydrazinium Nitroformate (HNF). This propellant delivers about 3,5% 9,3% higher performance (c*) than the best existing composite solid rocket propellant. Characteristics of ingredients and propellant formulations are presented together with the test results which demonstrate the increased performance compared to conventional high-performance propellants based on Ammonium Perchlorate (AP). The test equipment is being described as well as estimates of losses which occur in the test motor. This allows to estimate the expected performance in full-size rocket motors.
Static and dynamic response of a novel optical decision circuit (1998)

A novel Optical Decision Circuit (ODC) based on a Mach- Zehnder Interferometer with a Gain Clamped Semiconductor Optical Amplifier in each arm is proposed. Both its static and dynamic response from simulation results demonstrate that the ODC exhibits excellent reshaping capabilities. Also the high speed response of the ODC has been investigated.
Gas additive effects in CO chemical lasers (1976)

The effects of gas additives on optical gain of the CO chemical laser (CL) have been measured for N <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> , SO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> , H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> , HF, CF <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</inf> , CCl <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> F <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> , CO, OCS, N <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O, and NO. One of the more unusual additives, NO, has been used to control the output spectrum of a laser oscillator by controlled sequential quenching of the high bands. The significance of these results for total power enhancement, output spectrum control, and alternate diluent use is discussed.
Rotary type ultrasonic motor with bending spokes (2018)

In this paper, the rotary type ultrasonic motor with bending spokes using radial mode, which can improve the output performance of ultrasonic motor and decrease the cost of manufacture, is presented. The proposed ultrasonic motor has good performance in the output torque and speed. The structure is simple and compact, so it has low dependence on the machining precision. The voltage to drive the motor is low and excitation method is simple. It is suitable for large-scale industrial application also due to its low production cost and reliable output. The current ultrasonic motor is designed for small size flying objects. Moreover, it can be used in miniature helicopter motors and micro-electronic equipment zoom systems such as capsule endoscope, electronic eyeball, SLR camera, smart phone, etc. The proposed motor has a wide application prospect in robot, medical device, micromechanical and aerospace science and technology field. Numerical simulations and experimental outcomes are given. The experimental investigation of the motor has confirmed the main results of numerical analysis and has given an opportunity to create high speed rotation.
Multi‐Spectral Materials: Hybridisation of Optical Plasmonic Filters and a Terahertz Metamaterial Absorber (2013)

Multi-spectral materials, using hybridised plasmonic and metamaterial structures, can simultaneously exhibit unique resonant phenomena over several decades of wavelengths. A multi-spectral material that combines a plasmonic colour filter array and a terahertz metamaterial absorber into a single material is a promising prospect for a coaxial multi-spectral imager operating in the visible, near IR, and terahertz wavebands.