gebhart/patrepeval huggingface dataset:
The Dependence of Carbohydrate–Aromatic Interaction Strengths on the Structure of the Carbohydrate (2016)

Interactions between proteins and carbohydrates are ubiquitous in biology. Therefore, understanding the factors that determine their affinity and selectivity are correspondingly important. Herein, we have determined the relative strengths of intramolecular interactions between a series of monosaccharides and an aromatic ring close to the glycosylation site in an N-glycoprotein host. We employed the enhanced aromatic sequon, a structural motif found in the reverse turns of some N-glycoproteins, to facilitate face-to-face monosaccharide-aromatic interactions. A protein host was used because the dependence of the folding energetics on the identity of the monosaccharide can be accurately measured to assess the strength of the carbohydrate-aromatic interaction. Our data demonstrate that the carbohydrate-aromatic interaction strengths are moderately affected by changes in the stereochemistry and identity of the substituents on the pyranose rings of the sugars. Galactose seems to make the weakest and allose the strongest sugar-aromatic interactions, with glucose, N-acetylglucosamine (GlcNAc) and mannose in between. The NMR solution structures of several of the monosaccharide-containing N-glycoproteins were solved to further understand the origins of the similarities and differences between the monosaccharide-aromatic interaction energies. Peracetylation of the monosaccharides substantially increases the strength of the sugar-aromatic interaction in the context of our N-glycoprotein host. Finally, we discuss our results in light of recent literature regarding the contribution of electrostatics to CH-π interactions and speculate on what our observations imply about the absolute conservation of GlcNAc as the monosaccharide through which N-linked glycans are attached to glycoproteins in eukaryotes.
Downstream Transmission of Pre-Distorted 25-Gb/s Fasterthan-Nyquist PON with 10G-Class Optics Achieving over 31 dB Link Budget without Optical Amplification (2016)

We experimentally demonstrate 25-Gb/s downstream transmission over 20-km SSMF in a Faster-than-Nyquist PON with 10G-class optics based on pre-distorted NRZ, achieving -26 dBm receiver sensitivity and over 31 dB loss budget without any optical amplification.
Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma (2020)

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report clinically accurate and ultrasensitive detection of multiple AD core biomarkers (t-tau, p-tau<sub>181</sub>, Aβ<sub>42</sub>, and Aβ<sub>40</sub>) in human plasma using densely aligned carbon nanotubes (CNTs). The closely packed and unidirectionally aligned CNT sensor array exhibits high precision, sensitivity, and accuracy, evidenced by a low coefficient of variation (<6%), a femtomolar-level limit of detection, and a high degree of recovery (>93.0%). By measuring the levels of t-tau/Aβ<sub>42</sub>, p-tau<sub>181</sub>/Aβ<sub>42</sub>, and Aβ<sub>42</sub>/Aβ<sub>40</sub> in clinical blood samples, the sensor array successfully discriminates the clinically diagnosed AD patients from healthy controls with an average sensitivity of 90.0%, a selectivity of 90.0%, and an average accuracy of 88.6%.
Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs (2006)

Overall, when used appropriately, microdosing offers the potential to aid in early drug candidate selection.
Grain Structure and Magnetic Anisotropy of Fe Film Evaporated Obliquely from Two Sources (1981)

A columnar grain structure different from the conventional one has been found experimentally in Fe film evaporated at oblique incidence from two vapor sources positioned opposite one another. The direction of the columnar grain in the film is perpendicular to the substrate, and the column aggregates to form a row perpendicular to the plane of incidence. This formation has been discussed satisfactorily by simulation of the crystallite growth, and the grain structure has been confirmed by three-dimensional analysis of the magnetic anisotropy. Furthermore it is emphasized here that this structure brings out a larger magnetic anisotropy in the film plane than that of conventional film evaporated at oblique incidence.
Concealed AM/FM Antenna and Reception Subsystem for the Quarter Glass of SUV’s and Mini-Vans (1999)

<div class="section abstract"><div class="htmlview paragraph">A concealed antenna reception subsystem whose receiving antenna element is screened on the quarter glass of a Sport Utility Vehicle (SUV) or Mini-Van is described and demonstrated. System design requirements, topology of prior technology fixed mast reception systems that the concealed system replaces, the concealed antenna subsystem topology, a receiving antenna element, and reception system performance parameters and issues are discussed with examples and data.</div></div>
DReggie: Semantic Service Discovery for M-Commerce Applications (2001)

The emergence of mobile devices and wireless networks has created a new path in the field of e-commerce: “mcommerce”. Significant research is needed, in the field of service discovery, to support m-commerce applications. Various new applications, that would use services available to a mobile device from both the fixed network backbone and peer mobile devices in its proximity, are being developed. M-commerce applications have the challenging task of discovering services in a dynamically changing environment. The DARPA Agent Markup Language (DAML) is an important tool in the process of developing the Semantic Web. In this paper, we present a dynamic service discovery infrastructure that uses DAML to describe services and a Prolog reasoning engine to perform matching using the semantic content of service descriptions. We believe that the architecture we have designed is a necessary component of any m-commerce infrastructure.
Efficient Role Mining for Context-Aware Service Recommendation Using a High-Performance Cluster (2015)

Service recommendation systems have been trying to utilize context-aware information to recommend services that better meet the needs of the service consumers. However, current context-aware service recommendation techniques are mainly based on individual intelligence or the local knowledge of users, and do not take into consideration the common knowledge among different users. To address this, recent research has attempted to use role-based approaches to recommend services to other members within the same context group. However, these proposed algorithms are inefficient and may not scale to cope with the large amount of mobile traffic in the real-world. This paper proposes novel algorithms with better runtime complexity, and further extends them to a MapReduce style to take advantage of popular distributed computing platforms. Experiments running on a medium-sized high performance computing cluster demonstrate that our proposed algorithms outperform previous work in runtime complexity and scalability.
A new multifunctional, shine‐enhancing emollient: PPG‐3 benzyl ether myristate (2005)

A new emollient ester--Crodamol STS (INCI name: PPG-3 Benzyl Ether Myristate) has been developed and characterized. This special non-volatile emollient is safe to use and provides silicone-like feel and multiple cosmetic functionality. It is a liquid with a viscosity about 100 cps at room temperature. It has a high refractive index--1.4696, which enhances hair shine, contributes to high gloss in lip products, and reduces whitening effect of fatty alcohols and silica in anti-perspirants/deodorants applications. This emollient has high solubility of UV filters, low skin-spreading factor, and good pigment wetting behavior, which are preferable in sunscreen and make-up formulas to enhance the pigment localization and improve SPF value. In this paper, the chemical structure, physical properties, and various cosmetic applications of the emollient will be discussed. Especially, an objective hair shine (luster) test method (color image analysis) has been established and applied to study the enhancement in hair shine by Crodamol STS in hair spray and hair gel formulations. The objective measurements in hair shine showed good agreement with the results obtained from subjective evaluations. The substantivity of Crodamol STS on hair surface, which was delivered from a rinse-off cream, was also determined by a solvent extraction method.
Brain‐derived neurotrophic factor induces migration of endothelial cells through a TrkB–ERK–integrin α<sub>V</sub>β<sub>3</sub>–FAK cascade (2011)

Brain-derived neurotrophic factor (BDNF) promotes the regeneration of periodontal tissue. Since angiogenesis is important for tissue regeneration, investigating effect of BDNF on endothelial cell function may help to reveal its mechanism, whereby, BDNF promotes periodontal tissue regeneration. In this study, we examined the influence of BDNF on migration in human microvascular endothelial cells (HMVECs), focusing on the effects on extracellular signal-regulated kinase (ERK), integrin α(V)β(3), and focal adhesion kinase (FAK). The migration of endothelial cells was assessed with a modified Boyden chamber and a wound healing assay. The expression of integrin α(V)β(3) and the phosphorylation of ERK and FAK were analyzed by immunoblotting and immunofluorescence microscopy. BDNF (25 ng/ml) induced cell migration. PD98059, an ERK inhibitor, K252a, a specific inhibitor for TrkB, a high affinity receptor of BDNF, and an anti-integrin α(V)β(3) antibody suppressed the BDNF-induced migration. BDNF increased the levels of integrin α(V)β(3) and phosphorylated ERK1/2 and FAK. The ERK inhibitor and TrkB inhibitor also reduced levels of integrin α(V)β(3) and phosphorylated FAK. We propose that BDNF stimulates endothelial cell migration by a process involving TrkB/ERK/integrin α(V)β(3)/FAK, and this may help to enhance the regeneration of periodontal tissue.
Scalable and Secure Logistic Regression via Homomorphic Encryption (2016)

Logistic regression is a powerful machine learning tool to classify data. When dealing with sensitive data such as private or medical information, cares are necessary. In this paper, we propose a secure system for protecting the training data in logistic regression via homomorphic encryption. Perhaps surprisingly, despite the non-polynomial tasks of training in logistic regression, we show that only additively homomorphic encryption is needed to build our system. Our system is secure and scalable with the dataset size.
A Dynamic Resource Allocation Framework for Synchronizing Metaverse with IoT Service and Data (2022)

Spurred by the severe restrictions on mobility due to the COVID-19 pandemic, there is currently intense interest in developing the Metaverse, to offer virtual services/business online. A key enabler of such virtual service is the digital twin, i.e., a digital replication of real-world entities in the Metaverse, e.g., city twin, avatars, etc. The real-world data collected by IoT devices and sensors are key for synchronizing the two worlds. In this paper, we consider the scenario in which a group of IoT devices are employed by the Metaverse platform to collect such data on behalf of virtual service providers (VSPs). Device owners, who are self-interested, dynamically select a VSP to maximize rewards. We adopt hybrid evolutionary dynamics, in which heterogeneous device owner populations can employ different revision protocols to update their strategies. Extensive simulations demonstrate that a hybrid protocol can lead to evolutionary stable states.
Direct Monitoring of Vesicular Release and Uptake in Brain Slices by Multiphoton Excitation of the Styryl FM® 1-43 (2006)

Fluorescence imaging using FM 1-43 and related styryl dyes has provided invaluable insights into presynaptic function of synapses in culture preparations, but has been limited in use for studying central synapses in vivo or in brain slices, because of excessive fluorescence background due to nonspecific membrane binding of dye. We demonstrate here that focal excitation of FM dyes using two-photon laser-scanning microscopy (TPLSM) provides high resolution of FM 1-43-labeled nerve terminals in brain slices by suppressing out-of-focus background and that a readily releasable pool of vesicles can be selectively and stably labeled by hypertonic shock despite slice diffusion barriers. We find direct TPLSM of FM 1-43-labeled nerve terminals to be superior to treatment of slices with either the fluorescent quencher sulforhodamine 101 or dye scavenger ADVASEP-7 in resolving nerve terminal against background fluorescence, enabling continuous monitoring of vesicular uptake, and release of styryl dyes from individual nerve terminals in brain slices.
Food Packaging – a Technology (2023)

Partial table of contents: PART V: PACKAGING PROCEDURES FOR FINISHED FOODSTUFFS. Automatic Packaging Machines -- Packaging. Ionizing Treatment and Packaging -- Preservation of Foodstuffs Packed in Flexible Packaging. PART IV: SOME SIGNIFICANT EXAMPLES OF SECTORS OF THE FOODSTUFFS INDUSTRY WHERE PACKAGING IS RAPIDLY CHANGING. Packaging of Milk Products. Packaging for Vacuum Cooking. PART VII: METHODOLOGY AND ECONOMICS. Dimensional Coordination. The Quality. Price Ratio of Packaging and Its Effect on the Quality of the Final Product. Index.
Joule heating induced thermomigration failure in un-powered microbumps due to thermal crosstalk in 2.5D IC technology (2016)

Thermal-crosstalk induced thermomigration failure in un-powered microbumps has been found in 2.5D integrated circuit (IC) circuit. In 2.5D IC, a Si interposer was used between a polymer substrate and a device chip which has transistors. The interposer has no transistors. If transistors are added to the interposer chip, it becomes 3D IC. In our test structure, there are two Si chips placed horizontally on a Si interposer. The vertical connections between the interposer and the Si chips are through microbumps. We powered one daisy chain of the microbumps under one Si chip; however, the un-powered microbumps in the neighboring chip are failed with big holes in the solder layer. We find that Joule heating from the powered microbumps is transferred horizontally to the bottom of the neighboring un-powered microbumps, and creates a large temperature gradient, in the order of 1000 °C/cm, through the un-powered microbumps in the neighboring chip, so the latter failed by thermomigration. In addition, we used synchrotron radiation tomography to compare three sets of microbumps in the test structure: microbumps under electromigration, microbumps under thermomigration, and microbumps under a constant temperature thermal annealing. The results show that the microbumps under thermomigration have the largest damage. Furthermore, simulation of temperature distribution in the test structure supports the finding of thermomigration.
Demystifying Incentives in the Consensus Computer (2015)

Cryptocurrencies like Bitcoin and the more recent Ethereum system allow users to specify scripts in transactions and contracts to support applications beyond simple cash transactions. In this work, we analyze the extent to which these systems can enforce the correct semantics of scripts. We show that when a script execution requires nontrivial computation effort, practical attacks exist which either waste miners' computational resources or lead miners to accept incorrect script results. These attacks drive miners to an ill-fated choice, which we call the verifier's dilemma, whereby rational miners are well-incentivized to accept unvalidated blockchains. We call the framework of computation through a scriptable cryptocurrency a consensus computer and develop a model that captures incentives for verifying computation in it. We propose a resolution to the verifier's dilemma which incentivizes correct execution of certain applications, including outsourced computation, where scripts require minimal time to verify. Finally we discuss two distinct, practical implementations of our consensus computer in real cryptocurrency networks like Ethereum.
Rapid detection of regionally clustered germ-line BRCA1 mutations by multiplex heteroduplex analysis (1996)

Germ-line mutations of the BRCA1 gene are responsible for a substantial proportion of families with multiple cases of early-onset breast and/or ovarian cancer. Since the isolation of BRCA1 last year, >65 distinct mutations scattered throughout the coding region have been detected, making analysis of the gene time consuming and technically challenging. We have developed a multiplex heteroduplex analysis that is designed to analyze one-quarter of the coding sequence in a single-step screening procedure and that will detect {approximately}50% of all BRCA1 mutations so far reported in breast/ovarian cancer families. We have used this technique to analyze BRCA1 in 162 families with a history of breast and/or ovarian cancer and identified 12 distinct mutations in 35 families. 20 refs., 2 figs., 2 tabs.
Planar circularly symmetric EBG structures for reducing surface waves in printed antennas (2005)

This paper discusses the design and analysis of planar circularly symmetric (PCS) electromagnetic band gap (EBG) structures for reducing the surface waves excited by printed antennas on dense dielectric substrates. The key advantage of the circularly symmetric geometries is that a surface wave generated by a source located at its center experiences the same band gap effect in all radial directions. To obtain simple design rules of the PCS-EBGs for the optimization of the bandwidth, an equivalence is established between 2-D-EBGs and PCS-EBGs. Integrated planar printed antennas with bandwidths up to 20% are designed, manufactured and tested.
<i>In Situ</i> Observation of Oxygen Vacancy Dynamics and Ordering in the Epitaxial LaCoO<sub>3</sub> System (2017)

Vacancy dynamics and ordering underpin the electrochemical functionality of complex oxides and strongly couple to their physical properties. In the field of the epitaxial thin films, where connection between chemistry and film properties can be most clearly revealed, the effects related to oxygen vacancies are attracting increasing attention. In this article, we report a direct, real-time, atomic level observation of the formation of oxygen vacancies in the epitaxial LaCoO<sub>3</sub> thin films and heterostructures under the influence of the electron beam utilizing scanning transmission electron microscopy (STEM). In the case of LaCoO<sub>3</sub>/SrTiO<sub>3</sub> superlattice, the formation of the oxygen vacancies is shown to produce quantifiable changes in the interatomic distances, as well as qualitative changes in the symmetry of the Co sites manifested as off-center displacements. The onset of these changes was observed in both the [100]<sub>pc</sub> and [110]<sub>pc</sub> orientations in real time. Additionally, annular bright field images directly show the formation of oxygen vacancy channels along [110]pc direction. In the case of 15 u.c. LaCoO<sub>3</sub> thin film, we observe the sequence of events during beam-induced formation of oxygen vacancy ordered phases and find them consistent with similar processes in the bulk. Moreover, we record the dynamics of the nucleation, growth, and defect interaction at the atomic scale as these transformations happen. These results demonstrate that we can track dynamic oxygen vacancy behavior with STEM, generating atomic-level quantitative information on phase transformation and oxygen diffusion.
Metabolic Fingerprinting As A Diagnostic Tool (2007)

Within the framework of systems biology, functional analyses at all 'omic levels have seen an intense level of activity during the first decade of the twenty-first century. These include genomics, transcriptomics, proteomics, metabolomics and lipidomics. It could be said that metabolomics offers some unique advantages over the other 'omics disciplines and one of the core approaches of metabolomics for disease diagnostics is metabolic fingerprinting. This review provides an overview of the main metabolic fingerprinting approaches used for disease diagnostics and includes: infrared and Raman spectroscopy, Nuclear magnetic resonance (NMR) spectroscopy, followed by an introduction to a wide range of novel mass spectrometry-based methods, which are currently under intense investigation and developmental activity in laboratories worldwide. It is hoped that this review will act as a springboard for researchers and clinicians across a wide range of disciplines in this exciting era of multidisciplinary and novel approaches to disease diagnostics.
Transverse Mixing Enhancement due to Bacterial Random Motility in Porous Microfluidic Devices (2011)

Bacterial swimming in groundwater may create flow disturbances in the surrounding microenvironment thereby enhancing contaminant mixing. Porous microfluidic devices (MFDs) were fabricated in three different pore geometry designs: uniform grain size with large pore throats (MFD-I), nonuniform grain size with restricted pore space (MFD-II), and uniform grain size with small pore throats (MFD-III). Escherichia coli HCB33 was used to assess the effect of bacterial random motility on transverse mixing of a tracer, fluorescent labeled dextran, under three experimental conditions in which motile bacteria, nonmotile bacteria, and plain buffer suspensions were flown through the MFDs at four different flow rates. Mixing was quantified in terms of the best-fit effective transverse dispersion coefficient ((D(cy))(eff)). A mixing enhancement index (MEI) was defined as the ratio of the (D(cy))(eff) of tracer in experiments with motile bacteria and without bacteria. Motile bacteria caused a maximum 5-6 fold increase in MEI in MFD-II, a nearly 4-fold increase in MFD-I, and very little observed change in MFD-III. The apparent transverse dispersivities (α(app)) of MFD-II and MFD-I increased by 3 and 2.3 times, respectively, with no change in MFD-III. These observations indicate that both pore throat size and pore arrangement are critical factors for contaminant mixing in porous media.
A Pilot Study Examining Topical Amitriptyline, Ketamine, and a Combination of Both in the Treatment of Neuropathic Pain (2003)

This pilot study demonstrated a lack of effect for all treatments in the 2 day double blind placebo controlled trial, followed by analgesia in an open label trial in a subgroup of subjects who chose to use the combination cream for 7 days. Blood analysis revealed no significant systemic absorption of either agent after 7 days of treatment, and creams were well tolerated. A larger scale randomized trial over a longer interval is warranted to examine further effects observed in the open label trial.
Acute and Chronic Experimental Optic Neuritis (1984)

Horseradish peroxidase (HRP) tracer studies in experimental allergic optic neuritis showed alterations in the blood-optic nerve barrier. Light and electron microscopic examination of the optic disc disclosed intense leakage of HRP at the lamina scleralis, with extracellular staining of both axonal and glial columns, despite the lack of inflammation at this region. The intraorbital optic nerve showed leakage of HRP at the sites of both acute and chronic demyelination. Ultrastructurally, leakage of HRP was confined to the perivascular and extracellular spaces. The mechanism of leakage seems to be by diffusion through the endothelial cell junctions or vesicular transport across the endothelial cells. The high predilection for involvement of the optic nerve in chronic demyelinating disorders may be due to the inherent weakness of the blood-brain barrier at the optic nerve head.