gebhart/patrepeval huggingface dataset:
Optimization algorithm for ultrabroadband multichannel aperiodic fiber Bragg grating filters (2007)

We consider an approach to designing complex multichannel filters for ultrabroadband applications. In contrast to earlier approaches that are restricted to specific problems, our generalized method can be applied to any conceivable fiber Bragg grating (FBG) multichannel design. Our method accommodates hundreds of filter channels that are spaced unevenly in wavelength, with variable widths, depths, and shapes. We demonstrate the power of the method for an FBG design with 150 narrow channels over the region 1400-1800 nm.
Prognostic Value of T Cell Immunoglobulin Mucin-3 in Prostate Cancer (2013)

TIM-3 expression is associated with a poor prognosis in prostate cancer. Taken together, our results indicate that TIM-3 is a potential prognostic marker in prostate cancer.
N-Palmitoyl-D-Glucosamine Inhibits TLR-4/NLRP3 and Improves DNBS-Induced Colon Inflammation through a PPAR-α-Dependent Mechanism (2022)

Similar to canine inflammatory enteropathy, inflammatory bowel disease (IBD) is a chronic idiopathic condition characterized by remission periods and recurrent flares in which diarrhea, visceral pain, rectal bleeding/bloody stools, and weight loss are the main clinical symptoms. Intestinal barrier function alterations often persist in the remission phase of the disease without ongoing inflammatory processes. However, current therapies include mainly anti-inflammatory compounds that fail to promote functional symptoms-free disease remission, urging new drug discoveries to handle patients during this step of the disease. ALIAmides (ALIA, autacoid local injury antagonism) are bioactive fatty acid amides that recently gained attention because of their involvement in the control of inflammatory response, prompting the use of these molecules as plausible therapeutic strategies in the treatment of several chronic inflammatory conditions. N-palmitoyl-D-glucosamine (PGA), an under-researched ALIAmide, resulted in being safe and effective in preclinical models of inflammation and pain, suggesting its potential engagement in the treatment of IBD. In our study, we demonstrated that micronized PGA significantly and dose-dependently reduces colitis severity, improves intestinal mucosa integrity by increasing the tight junction proteins expression, and downregulates the TLR-4/NLRP3/iNOS pathway via PPAR-α receptors signaling in DNBS-treated mice. The possibility of clinically exploiting micronized PGA as support for the treatment and prevention of inflammation-related changes in IBD patients would represent an innovative, effective, and safe strategy.
Superoleophilic and Superhydrophobic Inverse Opals for Oil Sensors (2008)

Abstract An inverse opal with both superoleophilic (oil contact angle (CA), 5.1° ± 1.2°) and superhydrophobic (water CA, 153.8° ± 1.2°) properties is fabricated using a phenolic resin (PR) as precursor and poly(styrene‐methyl methacrylate‐acrylic acid) (poly(St‐MMA‐AA)) colloidal crystals as templates. The stopband of the inverse opal can shift reversibly upon sorption of oils, whereby the peak position is a linear function of the refractive index of the adsorbed oil, e.g., a variation in refractive index of 0.02 will result in a stopband shift of 26 nm. Therefore, the inverse opals show a high sensitivity and selectivity for different petroleum oils. Moreover, as‐prepared PR inverse opals show excellent oil‐sensing stability in cyclic sorption experiments, which suggests a promising and economical alternative to traditional oil‐sensing materials, and will provide a new approach to in situ petroleum monitoring and detection.
Pirfenidone: antifibrotic agent for idiopathic pulmonary fibrosis (2010)

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with rare incidence but high mortality, and the pathogenesis of which is still poorly understood. Available treatment options have been empirically applied but evidence-based benefits have not yet been confirmed. Pirfenidone is an antifibrotic agent that is potentially effective for IPF treatment. Preclinical studies have been reported using experimental animal models, which revealed inhibitory effects pn profibrotic and proinflammatory cytokines. Several clinical studies provided promising and reproducible effects for inhibition of IPF disease progression in different nations. The efficacy is demonstrated in patients with mild-to-moderate impairment of pulmonary functions, but not confirmed for patients with severe impairment. Major adverse events are photosensitivity and anorexia, but the treatment was generally safe and well tolerated. In this article, the usefulness and limitations of pirfenidone in IPF treatment are discussed to determine its potential for the management of IPF progression.
IAN: The Individual Aggregation Network for Person Search (2017)

Person search in real-world scenarios is a new challenging computer version task with many meaningful applications. The challenge of this task mainly comes from: (1) unavailable bounding boxes for pedestrians and the model needs to search for the person over the whole gallery images; (2) huge variance of visual appearance of a particular person owing to varying poses, lighting conditions, and occlusions. To address these two critical issues in modern person search applications, we propose a novel Individual Aggregation Network (IAN) that can accurately localize persons by learning to minimize intra-person feature variations. IAN is built upon the state-of-the-art object detection framework, i.e., faster R-CNN, so that high-quality region proposals for pedestrians can be produced in an online manner. In addition, to relieve the negative effect caused by varying visual appearances of the same individual, IAN introduces a novel center loss that can increase the intra-class compactness of feature representations. The engaged center loss encourages persons with the same identity to have similar feature characteristics. Extensive experimental results on two benchmarks, i.e., CUHK-SYSU and PRW, well demonstrate the superiority of the proposed model. In particular, IAN achieves 77.23% mAP and 80.45% top-1 accuracy on CUHK-SYSU, which outperform the state-of-the-art by 1.7% and 1.85%, respectively.
<i>Saccharomyces cerevisiae</i> Flap Endonuclease 1 Uses Flap Equilibration To Maintain Triplet Repeat Stability (2004)

Flap endonuclease 1 (FEN1) is a central component of Okazaki fragment maturation in eukaryotes. Genetic analysis of Saccharomyces cerevisiae FEN1 (RAD27) also reveals its important role in preventing trinucleotide repeat (TNR) expansion. In humans such expansion is associated with neurodegenerative diseases. In vitro, FEN1 can inhibit TNR expansion by employing its endonuclease activity to compete with DNA ligase I. Here we employed two yeast FEN1 nuclease mutants, rad27-G67S and rad27-G240D, to further define the mechanism by which FEN1 prevents TNR expansion. Using a yeast artificial chromosome system that can detect both TNR instability and fragility, we demonstrate that the G240D but not the G67S mutation increases both the expansion and fragility of a CTG tract in vivo. In vitro, the G240D nuclease is proficient in cleaving a fixed nonrepeat double flap; however, it exhibits severely impaired cleavage of both nonrepeat and CTG-containing equilibrating flaps. In contrast, wild-type FEN1 and the G67S mutant exhibit more efficient cleavage on an equilibrating flap than on a fixed CTG flap. The degree of TNR expansion and the amount of chromosome fragility observed in the mutant strains correlate with the severity of defective flap cleavage in vitro. We present a model to explain how flap equilibration and the unique tracking mechanism of FEN1 can collaborate to remove TNR flaps and prevent repeat expansion.
Characterization, prediction, and correction of geometric distortion in MR images (2007)

The work presented herein describes our methods and results for predicting, measuring and correcting geometric distortions in a 3 T clinical magnetic resonance (MR) scanner for the purpose of image guidance in radiation treatment planning. Geometric inaccuracies due to both inhomogeneities in the background field and nonlinearities in the applied gradients were easily visualized on the MR images of a regularly structured three-dimensional (3D) grid phantom. From a computed tomography scan, the locations of just under 10 000 control points within the phantom were accurately determined in three dimensions using a MATLAB-based computer program. MR distortion was then determined by measuring the corresponding locations of the control points when the phantom was imaged using the MR scanner. Using a reversed gradient method, distortions due to gradient nonlinearities were separated from distortions due to inhomogeneities in the background B0 field. Because the various sources of machine-related distortions can be individually characterized, distortions present in other imaging sequences (for which 3D distortion cannot accurately be measured using phantom methods) can be predicted negating the need for individual distortion calculation for a variety of other imaging sequences. Distortions were found to be primarily caused by gradient nonlinearities and maximum image distortions were reported to be less than those previously found by other researchers at 1.5 T. Finally, the image slices were corrected for distortion in order to provide geometrically accurate phantom images.
Diode Laser Induced Fluorescence for Gas-Phase Diagnostics (2011)

Abstract We highlight the capabilities and potential of diode laser induced fluorescence for measurements in gas-phase reacting flows. Many applications of diode lasers in practical sensing are based on absorption spectroscopy. Fluorescence-based diagnostics possess similar advantages in terms of practicality and implementation-cost but additionally are capable of achieving excellent spatial resolution. Diode laser fluorescence instruments have been employed for high-sensitivity trace gas monitoring in applications ranging from plasma physics to atmospheric chemistry. This article begins by describing the UV-visible diode laser technology used to perform fluorescence. The principles of diode laser induced fluorescence are then reviewed and a comparison is made with absorption spectroscopy. Examples are given of concentration measurements of both atomic and molecular trace gases. Recent work on using diode laser induced atomic fluorescence for precision measurements of flame temperature is also reviewed. We conclude by a discussion of future opportunities for diode laser fluorescence spectroscopy drawing attention to interesting potential target species as well as novel application areas, such as monitoring of synthesis processes for nanomaterials.
A State Duration Model for Brand Choice and Inter-Purchase Time (2021)

A new approach for analyzing state duration data in brand-choice studies is explored. This approach not only incorporates the correlation among repeated purchases for a subject, it also models the purchase timing and the brand decision jointly. The former is accomplished by applying transition model approaches from longitudinal studies while the latter is done by conditioning on the brand choice variable. Then mixed multinomial logit models and Cox proportional hazards models are employed to model the marginal densities of the brand choice and the conditional densities of the interpurchase time given the brand choice. We illustrate the approach using a Nielsen household scanner panel data set
Kalman Filter-Based Hybrid Indoor Position Estimation Technique in Bluetooth Networks (2013)

This paper presents an extended Kalman filter-based hybrid indoor position estimation technique which is based on integration of fingerprinting and trilateration approach. In this paper, Euclidian distance formula is used for the first time instead of radio propagation model to convert the received signal to distance estimates. This technique combines the features of fingerprinting and trilateration approach in a more simple and robust way. The proposed hybrid technique works in two stages. In the first stage, it uses an online phase of fingerprinting and calculates nearest neighbors (NN) of the target node, while in the second stage it uses trilateration approach to estimate the coordinate without the use of radio propagation model. The distance between calculated NN and detective access points (AP) is estimated using Euclidian distance formula. Thus, distance between NN and APs provides radii for trilateration approach. Therefore, the position estimation accuracy compared to the lateration approach is better. Kalman filter is used to further enhance the accuracy of the estimated position. Simulation and experimental results validate the performance of proposed hybrid technique and improve the accuracy up to 53.64% and 25.58% compared to lateration and fingerprinting approaches, respectively.
Transcription of Human ABO Histo-blood Group Genes Is Dependent upon Binding of Transcription Factor CBF/NF-Y to Minisatellite Sequence (1997)

We have studied the transcriptional regulatory mechanism of the human histo-blood group ABO genes, and identified DNA cis-elements and trans-activating protein that control the expression of these genes which are important in blood transfusion and organ transplantation. We introduced the 5'-upstream sequence of ABO genes into the promoterless reporter vector and characterized the promoter activity of deletion constructs using transient transfection assays with gastric cancer cell line KATO III cells. The sequence just upstream of the transcription start site (cap site), and an enhancer element, which is located further upstream (between -3899 and -3618 base pairs (bp) from the transcription initiation site) and contains 4 tandem copies of a 43-bp repeat unit, were shown in gastric cancer cells to be responsible for the transcriptional activity of the ABO genes. DNA binding studies have demonstrated that a transcription factor, CBF/NF-Y, bound to the 43-bp repeat unit in the minisatellite. Functional importance of these CBF/NF-Y-binding sites in enhancer activity was confirmed by transfection experiments using reporter plasmids with mutated binding sites. Thus, transcriptional regulation of the human ABO genes is dependent upon binding of CBF/NF-Y to the minisatellite.
Photon-hopping conduction and collectively induced transparency in a photonic band gap (1995)

We study the dynamics of photon-hopping conduction between impurity atoms in a photonic band gap via resonance dipole-dipole interaction (RDDI) in the low-excitation density limit. This is done both in the absence and in the presence of a localized dielectric defect mode. The random impurity atom positions are modeled by means of a Gaussian random distribution of RDDI's with variance J and atomic line fluctuations with variance \ensuremath{\delta}. By numerical calculation, we demonstrate the occurrence of a number of collective quantum features of photon-hopping conduction. These include collective enhancement of the energy-transfer rate and collectively induced transparency within the dielectric cavity mode. These effects are shown to depend sensitively on the variances J and \ensuremath{\delta}. Our results suggest that RDDI mediated hopping conduction may protect atomic excitation energy from dissipation through nonradiative relaxation channels.
ROLE OF ACTIVATED INTRARENAL REACTIVE OXYGEN SPECIES AND RENIN–ANGIOTENSIN SYSTEM IN IgA NEPHROPATHY MODEL MICE (2009)

1. Using HIGA (high IgA of ddY) mice as an IgA nephropathy model and BALB/c mice as controls, we demonstrated that reactive oxygen species (ROS) and the renin-angiotensin system (RAS) were activated in kidneys of HIGA mice. However, it was difficult to establish an association between renal damage and changes in ROS and the RAS. Therefore, the present study was performed to determine whether renal injury is associated with changes in ROS and the RAS in HIGA mice. 2. Male HIGA mice were divided into four groups of 10 each: (i) untreated mice (HIGA + null); (ii) mice treated with the angiotensin AT(1) receptor antagonist olmesartan (5 mg/kg per day; HIGA + OLM); (iii) mice treated with the superoxide dismutase mimetic tempol (50 mg/kg per day; HIGA + Tempol); and (iv) mice treated with RAS-independent antihypertensive drugs (30 mg/kg per day hydralazine, 0.6 mg/kg per day reserpine and 12 mg/kg per day hydrochlorothiazide; HIGA + HRH). Mice were treated for 5 weeks. 3. Systolic blood pressure decreased significantly in the HIGA + OLM and HIGA + HRH groups, but not in the HIGA + Tempol group, compared with HIGA + null mice. The expression of two ROS markers (4-hydroxy-2-nonenal and heme oxygenase-1) and angiotensin II as a marker of the RAS decreased significantly in HIGA + OLM and HIGA + Tempol mice, but not in HIGA + HRH mice, compared with HIGA + null mice. As a marker of renal damage, mesangial matrix expansion and the desmin-positive area decreased significantly in the HIGA + OLM and HIGA + Tempol groups, but not in HIGA + HRH group, compared with the HIGA + null group. 4. These data suggest that intrarenal ROS and RAS activation play a pivotal role in the development of IgA nephropathy model mice, from the early phase, independent of blood pressure.
Multilevel models Improve precision and Speed of IC <sub>50</sub> Estimates (2016)

The multilevel model yields a significant reduction of extreme IC50 estimates, an increase in precision and it runs orders of magnitude faster.
Bacteriophages a potential biocontrol agent against walnut blight (<i>Xanthomonas campestris</i> pv juglandis) (2001)

During autumn 2000 isolates of bacteria were collected from blighted nuts leaves buds and petioles of walnut trees from all over New Zealand From among these isolates Xanthomonas campestris pv juglandis lines were identified by a range of cultural DNA fingerprinting and morphological tests Concurrently bacteriophages which attack X campestris pv juglandis were isolated from the soils under the same trees Phages were readily isolated from a depth of 25 cm In the following spring phages were also isolated from the canopy of trees grown at Lincoln Phage typing was carried out to produce a set of phages capable of destroying all bacterial isolates A subset of the isolated phages was characterized Several phages isolated from the soil were identified under the electron microscope as being from the 955; phage group with long unsheathed tails and hexagonal heads Phages isolated from the canopy belonged to several other groups of phages Short term storage had little effect on canopy phage survivability Differences in hardiness were found between the phages The search to locate effective hardy phages for use as biobactericides continues
Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model (2017)

The ability of a novel intranasally delivered amnion cell derived biologic to suppress inflammation, prevent neuronal damage and preserve neurologic function in the experimental autoimmune encephalomyelitis animal model of multiple sclerosis was assessed. Currently, there are no existing optic nerve treatment methods for disease or trauma that result in permanent vision loss. Demyelinating optic nerve inflammation, termed optic neuritis, induces permanent visual dysfunction due to retinal ganglion cell damage in multiple sclerosis and experimental autoimmune encephalomyelitis. ST266, the biological secretome of Amnion-derived Multipotent Progenitor cells, contains multiple anti-inflammatory cytokines and growth factors. Intranasally administered ST266 accumulated in rodent eyes and optic nerves, attenuated visual dysfunction, and prevented retinal ganglion cell loss in experimental optic neuritis, with reduced inflammation and demyelination. Additionally, ST266 reduced retinal ganglion cell death in vitro. Neuroprotective effects involved oxidative stress reduction, SIRT1-mediated mitochondrial function promotion, and pAKT signaling. Intranasal delivery of neuroprotective ST266 is a potential novel, noninvasive therapeutic modality for the eyes, optic nerves and brain. The unique combination of biologic molecules in ST266 provides an innovative approach with broad implications for suppressing inflammation in autoimmune diseases, and for preventing neuronal damage in acute neuronal injury and chronic neurodegenerative diseases such as multiple sclerosis.
Improved single and multiaperature waveguide coupling theory, including explanation of mutual interactions (1980)

Bethe's small aperture coupling theory, modified by Cohn for large coupling apertures, is improved by including correction terms obtained by averaging the fields over the large aperture. Additionally, inclusion of nonempirical thickness correction factors derived previously by McDonald give coupling formulas which result in theoretical predictions for multiaperture couplers substantially in exact agreement with experiment (correcting small discrepancies previously noted by the author in a 1968 paper). This agreement is now so close that it becomes possible both to identify and explain the mutual interaction effects between closely spaced apretures in multiaperture couplers. It is shown that the mutual interaction is due to contradirectional (or backward) waves in the secondary arm, so that multiaperture interactions are manifested as elimination of the self-interactions of the individual apertures (since the high directivity of typical multiaperture couplers implies negligible backward wave amplitude).
A Design of Certificate Authority Based on Elliptic Curve Cryptography (2010)

CA (Certificate Authority) acts as the trusted third party, which serves to issue digital certificates and validate them in PKI (Public Key Infrastructure). Hence it's significant to ensure the CA system's security. The ECC (Elliptic Curve Cryptography) has the advantages of shorter key and higher efficiency, comparing with other public key cryptographies such as RSA. The purpose of this work is to design and implement a CA based on ECC by using Java programming technique, which can sign X.509v3 digital certificate to client and then validate client certificate. In application, the key pair (including public key and private key) can be got from the PKCS#12 (Public Key Cryptography Standard), which is used in encryption, decryption and digital signature. The ECC-based CA is used in the system of DRM (Digital Rights Management) to contribute to confidentiality, authenticity, integrality and non-repudiation in communication.
Using shim technology to monitor DCE runtime performance (1997)

Obtaining performance data for application or system software is typically di cult, especially when the source code is not available. While popular techniques suchasevent trapping or monitoring external network tra c may provide some indication of performance, their various shortcomings restrict the domain of applicability. In this paper, we illustrate a new approach to obtaining performance data that appears to address some of these concerns and demonstrate it in the context of DCE applications and system services. This approach is architecture-independent, does not rely on application or system services source code, and is easy to use. 1
The Willem C v International Commercial Arbitration Moot 2004-05 (2005)

Not Available The Author: Mr Tomas Fitzgerald