gebhart/patrepeval huggingface dataset:
Evidence for hepatitis C viral infection in patients with primary hepatocellular carcinoma. (1994)

In testing for antibodies to the hepatitis C virus (anti-HCV) in 112 patients with primary hepatocellular carcinoma, 10 of 33 white patients (30%) and 15 of 79 Asian patients (19%) had a positive response to the antibody. The antibody profile to individual hepatitis C viral antigens and the presence of circulating hepatitis C viral RNA were determined in the 25 patients. The anti-HCV antibodies most frequently detected were toward the antigens from the core (C22) and NS3 regions. Serum hepatitis C viral RNA was present in 17 of the 25 patients (68%), and these patients tended to have serum levels of alanine and aspartate aminotransferases higher than those patients without viremia (136 +/- 22 U per liter versus 64 +/- 11 U per liter and 161 +/- 26 U per liter versus 79 +/- 14 U per liter, respectively, both P < .05). Of the 15 Asian patients with hepatocellular carcinoma and anti-HCV, 4 (27%) had coexisting hepatitis B surface antigen (HBsAg) and 13 (87%) had antibodies to either hepatitis B core or surface antigen. Of the 10 white patients with anti-HCV, however, only 1 (10%) had hepatitis B virus antibodies (P < .01). Among 4 Asian patients with coexisting anti-HCV and HBsAg, 1 was found to have serum hepatitis B viral DNA and the other 3 had hepatitis C viral RNA. A history of blood transfusion was obtained from 12 of the 25 patients with anti-HCV (48%); 20 (80%) had coexisting cirrhosis. Our findings support the hypothesis that hepatitis C virus is an important etiologic agent in the development of primary hepatocellular carcinoma in both white and Asian patients in the United States.
Activation of iPr(CpFluo)ZrCl2 by methylaluminoxane, 3. Kinetic investigation of the syndiospecific hex-1-ene polymerization in hydrocarbon and chlorinated media (1999)

The homopolymerization of hex-1-ene in presence of the iPr(CpFluo)ZrCl2/MAO system has been investigated in solvents of various polarity and coordinating power (toluene, methylene dichloride and o-dichlorobenzene). Polymerization kinetics were monitored by dilatometry. A strong enhancement of the activity is observed in polar solvents compared to toluene. Besides, the use of polar media enables to reduce drastically the amount of methylaluminoxane (MAO) to reach the plateau of maximum activity. However, unlike the rac-Et(Ind)2ZrCl2/MAO system, a rapid deactivation of the active species is observed in the different solvents examined in the case of the iPr(CpFluo)ZrCl2/MAO catalyst. Moreover, in CH2Cl2, an important loss of the catalyst syndiospecificity, proportional to the monomer concentration, is observed. The possible mechanisms involved are discussed.
Trial Manufacture of Eccentric Roller Type Total Artificial Heart (1997)

Working toward a completely implantable total artificial heart, we have designed an eccentric roller type total artificial heart. The actuator of this artificial heart is a drum type eccentric roller that squeezes the blood chambers. The blood chambers are made of silicone rubber and are torus in shape. The shape of the artificial heart is an almost circular cylinder, and its length and diameter are 10 cm and 8 cm, respectively. The 2 main characteristics of this artificial heart are that it discharges blood in a pulsatile mode and that it requires no reversing of the motor. Because we have not completed the artificial heart yet, we have tested the eccentric roller mechanism on the prototype with an overflow type mock circulation with a 100 mm Hg afterload. The prototype worked at the roller speeds of 50, 100, and 150 rpm with flow rates of 1.7, 3.7, and 5.4 L/min, respectively. Next the prototype was connected to a Donovan type mock circulatory system and worked at roller speeds of 88-214 rpm with flow rates of 3.0-8.4 L/min against mean afterloads of 82-120 mm Hg.
Measurement and correction of ultrasonic pulse distortion produced by the human breast (1995)

Ultrasonic wavefront distortion produced by transmission through breast tissue specimens was measured in a two-dimensional aperture. Differences in arrival time and energy level between the measured waveforms and references that account for geometric delay and spreading were calculated. Also calculated was a waveform similarity factor that is decreased from 1.0 by changes in waveform shape. For nine different breast specimens, the arrival time fluctuations had an average (+/- s.d.) rms value of 66.8 (+/- 12.6) ns and an associated correlation length of 4.3 (+/- 1.1) mm, while the energy level fluctuations had an average rms value of 5.0 (+/- 0.5) dB and a correlation length of 3.4 (+/- 0.8) mm. The corresponding waveform similarity factor was 0.910 (+/- 0.023). The effect of the wavefront distortion on focusing and the ability of time-shift compensation to remove the distortion were evaluated by comparing parameters such as the -30-dB effective radius, the -10-dB peripheral energy ratio, and the level at which the effective radius departs from an ideal by 10% for the focus obtained without compensation, with time-shift estimation and compensation in the aperture, and with time-shift estimation and compensation performed after backpropagation. For the nine specimens, the average -10-dB peripheral energy ratio of the focused beams fell from 3.82 (+/- 1.83) for the uncompensated data to 0.96 (+/- 0.18) with time-shift compensation in the aperture and to 0.63 (+/- 0.07) with time-shift compensation after backpropagation. The average -30-dB effective radius and average 10% deviation level were 4.5 (+/- 0.8) mm and -19.2 (+/- 3.5) dB, respectively, for compensation in the aperture and 3.2 (+/- 0.7) mm and -22.8 (+/- 2.8) dB, respectively, for compensation after backpropagation. The corresponding radius for the uncompensated data was not meaningful because the dynamic range of the focus was generally less than 30 dB in the elevation direction, while the average 10% deviation level for the uncompensated data was -4.9 (+/- 4.1) dB. The results indicate that wavefront distortion produced by breast significantly degrades ultrasonic focus in the low MHz frequency range and that much of this degradation can be eliminated using wavefront backpropagation and time-shift compensation.
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin (2006)

Glyceryl trinitrate (GTN), also known as nitroglycerin, has been used to treat angina and heart failure for more than 130 years. Recently, it was shown that mitochondrial aldehyde dehydrogenase-2 (ALDH2) is responsible for formation of NO, the metabolite needed for GTN efficacy. In the present study, we show that the common G-to-A polymorphism in exon 12 of ALDH2--resulting in a Glu504Lys replacement that virtually eliminates ALDH2 activity in both heterozygotes and homozygotes--is associated with a lack of efficacy of sublingual GTN in Chinese subjects. We also show that the catalytic efficiency (Vmax/Km) of GTN metabolism of the Glu504 protein is approximately 10-fold higher than that of the Lys504 enzyme. We conclude that the presence of the Lys504 allele contributes in large part to the lack of an efficacious clinical response to nitroglycerin; we recommend that this genetic factor be considered when administering nitroglycerin to patients, especially Asians, 30-50% of whom possess the inactive ALDH2*2 mutant allele.
Epstein-Barr virus gene expression in P3HR1-superinfected Raji cells (1987)

The pattern of Epstein-Barr virus (EBV) RNAs expressed in Raji cells superinfected with P3HR1 EBV was examined. RNAs whose expression was of an immediate-early type (resistant to treatment of the cells with anisomycin) were identified. These RNAs, encoding the EBV reading frames BZLF1 and BRLF1, were probably expressed from defective virus within the P3HR1 preparation, and some of them were responsible for the induction of the EBV productive cycle in the Raji cells. The structures of the B95-8 RNAs equivalent to the anisomycin-resistant RNAs were determined. The RNA encoding the BZLF1 reading frame contained two splices which extended and modified the reading frame from that previously described.
Credit and Bankruptcy in a Temporary Equilibrium Model (2018)

A temporary general equilibrium in bankruptcy model with finite periods was analyzed in this paper, which (i) every consumer only issues one type of bond to financial market in each period; (ii) the bank has right to circulate currency, and never face bankruptcy. The model was an extesion of the Bankruptcy model in Eichberger(1989), based on the assumptions that the occurrence of moral hazard is prevented by the credit scheme law, which depends on the current information and forecast function. The main result of this paper enables as to develop the liquidation rule without penalties. This rule can also be used to interpret liquidating distribution in Bankruptcy Act. In addition, the bankruptcy mechanism plays an effective role even if the chain-reaction bankruptcy occurred. Moreover, we can prove that the economy will never collapse in an overlapping model which has some newborn in every period.
The Coordinate Geometry of Three-dimensional Space (1981)

It is now time to enter the real world of three dimensions. In order to introduce cartesian coordinates we necessarily require three mutually perpendicular axes, labelled x, y and z-axes, all of which meet at a common point, the coordinate origin. There are two independent ways of placing these axes, known as left-handed and right-handed triads of axes. In both types we may place the x and y-axes as in two-dimensional space, in the plane of the page (or screen) — the positive x axis placed to the right of the origin and the positive y-axis above the origin. This just leaves the placement of the z-axis (whence the two classifications of triads); it may be into the page (left-handed) or out of the page (right-handed). In this book we always use the left-handed notation.
Model systems and photo-kinetics of single N-V defect centers in diamond (2005)

Summary form only given. Fluorescence excitation method of single molecule spectroscopy has been applied recently to study individual nitrogen-vacancy (N-V) defect centers in diamond. These objects are of great interest owing to the proposal to build quantum computer at /sup 13/C nuclear spins neighboring the N-V center. Based on new spectroscopic information we have developed simple models of the N-V center and used them to describe a wide range of experiments dealing both with single centers and with their ensembles. The first model emphasizes possible tunneling of N atom into vacancy and describes that in terms of double well potentials. The second model takes into account the spin-triplet character of the ground electronic state of the center and allows to describe a variety of fluorescence detected magnetic resonance phenomena.
Repetition and Language Models and Comparable Corpora. (2011)

I will discuss a couple of non-standard features that I believe could be useful for working with comparable corpora. Dotplots have been used in biology to find interesting DNA sequences. Biology is interested in ordered matches, which show up as (possibly broken) diagonals in dot-plots. Information Retrieval is more interested in unordered matches (e.g., cosine similarity), which show up as squares in dotplots. Parallel corpora have both squares and diagonals multiplexed together. The diagonals tell us what is a translation of what, and the squares tell us what is in the same language. I would expect dotplots of comparable corpora would contain lots of diagonals and squares, though the diagonals would be shorter and more subtle in comparable corpora than in parallel corpora.
Immune Blockade Inhibition in Breast Cancer (2016)

Besides limited success in treatment of melanoma and renal cell carcinoma, immune treatments of cancer (cancer immunotherapy) had not until recently met the great expectations associated with them over the years. This failure appears now to be reversed with the introduction of checkpoint (immune blockade) inhibitors. Two receptor-ligand checkpoint inhibition pairs, the one based on the inhibition of inhibitory receptor cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and the other based on the inhibition of the programmed death-ligand 1/programmed cell death-1 (PD-L1/PD-1) pair have entered the clinical arena. Melanoma leads the way followed by non-small cell lung cancer (NSCLC) in both of which such drugs are already approved for clinical use. Several other cancer types will follow as trials data accumulate. Breast cancer clinical data are mixed so far and the arising picture is one of efficacy dependent on sub-types and sub-sets. This article will review available data on checkpoint molecules expression in breast cancer cells that may be one determinant factor of effective inhibition, as well as other possible biomarkers of immune blockade inhibitors effectiveness in breast cancer. Emerging data of clinical trials of immune checkpoint inhibitors in breast cancer will also be presented. Development and validation of reliable predictive markers of response to this new category of anti-cancer drugs will help optimize results and spare patients not expected to respond the toxicity and cost of the drugs. Moreover, predictive markers may advance the understanding of resistance to these therapies in order to reverse it.
Inferring user interests in the Twitter social network (2014)

We propose a novel mechanism to infer topics of interest of individual users in the Twitter social network. We observe that in Twitter, a user generally follows experts on various topics of her interest in order to acquire information on those topics. We use a methodology based on social annotations (proposed earlier by us) to first deduce the topical expertise of popular Twitter users, and then transitively infer the interests of the users who follow them. This methodology is a sharp departure from the traditional techniques of inferring interests of a user from the tweets that she posts or receives. We show that the topics of interest inferred by the proposed methodology are far superior than the topics extracted by state-of-the-art techniques such as using topic models (Labeled LDA) on tweets. Based upon the proposed methodology, we build a system Who Likes What, which can infer the interests of millions of Twitter users. To our knowledge, this is the first system that can infer interests for Twitter users at such scale. Hence, this system would be particularly beneficial in developing personalized recommender services over the Twitter platform.
Ticket Based Identity System for DRM. (2006)

One of the major stumbling blocks in achieving interoperability in DRM systems is due to the variety of different user authentication systems utilised by DRM systems. For example, in [6], the authors detailed how Microsoft’s Rights Management System fails in fulfilling its requirements mainly because of a lack of its user identity system. The authors discussed how, because one DRM system cannot authenticate users from another DRM system, it cannot offer interoperability, even if they shared the same data formats. Furthermore, interoperability for user authentication in DRM systems is further hampered by the wide range of devices that need to support DRM enabled data, but do not necessarily offer the same features. Decoupling of user identity from the main DRM system also reduces the chances of correlating users’ access patterns of protected works. This improves the privacy of users of DRM systems, another major criticisms of current DRM systems. In this paper we discuss the requirements for user identity in a DRM system and then introduce a Kerberos like reusable ticket based user identity system. This system allows multiple systems to be authenticated by the use of time limited authentication tickets, without requiring online authentication. Tickets can be stored at a central controlling point, which is also responsible for acquiring tickets from authentication servers and redistributing tickets to the devices that need the tickets. In our experience, our approach fulfils all the requirements and is a more scalable and inter-operable approach when compared to existing DRM systems. TICKET BASED IDENTITY SYSTEM FOR DRM
Dynamic acousto-optic control of a strongly coupled photonic molecule (2015)

Strongly confined photonic modes can couple to quantum emitters and mechanical excitations. To harness the full potential in quantum photonic circuits, interactions between different constituents have to be precisely and dynamically controlled. Here, a prototypical coupled element, a photonic molecule defined in a photonic crystal membrane, is controlled by a radio frequency surface acoustic wave. The sound wave is tailored to deliberately switch on and off the bond of the photonic molecule on sub-nanosecond timescales. In time-resolved experiments, the acousto-optically controllable coupling is directly observed as clear anticrossings between the two nanophotonic modes. The coupling strength is determined directly from the experimental data. Both the time dependence of the tuning and the inter-cavity coupling strength are found to be in excellent agreement with numerical calculations. The demonstrated mechanical technique can be directly applied for dynamic quantum gate operations in state-of-the-art-coupled nanophotonic, quantum cavity electrodynamic and optomechanical systems.
3D CAD Model Representation and Retrieval based on Hierarchical Graph (2014)

Due to 3D CAD models are often characterized with complicated geometry and topology, how to help the designers quickly and accurately find the object models from the database containing massive amount of models using the relatively rough query instance is still a big challenge. In this paper, a novel representation of 3D CAD models using hierarchical graph (HG) is proposed. The model descriptors are divided into shape feature descriptors and topology relationship descriptors. These two descriptors can be extracted from HG. In this way, coarse-grained and fine-grained 3D CAD model retrieval are implemented. On this basis, a 3D model retrieval method is proposed based on genetic algorithm (GA) and ant colony optimization (ACO), which are employed to detect the common sub-graph in the corresponding the hierarchical graphs of different models. This method can improve the accuracy and efficiency of 3D CAD model retrieval. Based on the above researches, a 3D model retrieval system HUST-CMRS is developed. Our experimental results show that, the algorithm proposed in this paper can implement multi-mode indexing and satisfy personalized need of users.
Modelling the effect of hydration on skin conductivity (2016)

The variation in impedance with conductivity between 5 and 50 mSm<sup>-1</sup> can be modelled quadratically while variation in impedance with conductivity between 5 and 5000 mSm<sup>-1</sup> can be modelled with a double exponential decay.
Smartphone-enabled optofluidic exosome diagnostic for concussion recovery (2016)

A major impediment to improving the treatment of concussion is our current inability to identify patients that will experience persistent problems after the injury. Recently, brain-derived exosomes, which cross the blood-brain barrier and circulate following injury, have shown great potential as a noninvasive biomarker of brain recovery. However, clinical use of exosomes has been constrained by their small size (30-100 nm) and the extensive sample preparation (>24 hr) needed for traditional exosome measurements. To address these challenges, we developed a smartphone-enabled optofluidic platform to measure brain-derived exosomes. Sample-to-answer on our chip is 1 hour, 10x faster than conventional techniques. The key innovation is an optofluidic device that can detect enzyme amplified exosome biomarkers, and is read out using a smartphone camera. Using this approach, we detected and profiled GluR2+ exosomes in the post-injury state using both in vitro and murine models of concussion.
So far away and yet so close (2016)

Place similarity has a central role in geographic information retrieval and geographic information systems, where spatial proximity is frequently just a poor substitute for semantic relatedness. For applications such as toponym disambiguation, alternative measures are thus required to answer the non-trivial question of place similarity in a given context. In this paper, we discuss a novel approach to the construction of a network of locations from unstructured text data. By deriving similarity scores based on the textual distance of toponyms, we obtain a kind of relatedness that encodes the importance of the co-occurrences of place mentions. Based on the text of the English Wikipedia, we construct and provide such a network of place similarities, including entity linking to Wikidata as an augmentation of the contained information. In an analysis of centrality, we explore the networks capability of capturing the similarity between places. An evaluation of the network for the task of toponym disambiguation on the AIDA CoNLL-YAGO dataset reveals a performance that is in line with state-of-the-art methods.
Fabrication of an asymmetric Bragg coupler-based polymeric filter with a single-grating waveguide (2011)

In this work, a first report on fabricating an asymmetric Bragg coupler-based filter on polymeric waveguides without input-waveguide grating was revealed. The fabrication process we developed was using holographic interference techniques, capillary effect, soft lithography, and micro molding process. The transmission dip of about -9.2 dB and the 3 dB transmission bandwidth of about 0.125 nm were obtained from a filter.
Myelofibrosis: an update on drug therapy in 2016 (2016)

Primary myelofibrosis (PMF) is the least common but the most aggressive of the classic Philadelphia chromosome-negative myeloproliferative neoplasms. Survival is much shorter in PMF than in polycythemia vera (PV) or essential thrombocythemia (ET). Post-PV/ET myelofibrosis (MF) is clinically indistinguishable from PMF and approached similarly. Areas covered: Current pharmacologic therapy of MF revolves around the Janus kinase 1/2 (JAK1/2) inhibitor ruxolitinib, which dramatically improves constitutional symptoms and splenomegaly in the majority of patients, and improves overall survival (OS). However, allogeneic stem cell transplantation remains the only potential cure. Other JAK inhibitors continue to be developed for MF, and momelotinib and pacritinib are in phase III clinical trials. Anemia is common in MF, and initially worsened by ruxolitinib. Momelotinib and pacritinib may prove advantageous in this regard. Current strategies for managing anemia of MF include danazol, immunomodulatory drugs and erythroid stimulating agents, either alone or in combination with ruxolitinib. Expert opinion: A number of other agents, representing diverse drug classes, are in various stages of development for MF. These include newer JAK inhibitors, other signaling inhibitors, epigenetic modifiers, anti-fibrotic agents, telomerase inhibitors, and activin receptor ligand traps (for anemia). Hopefully, these novel therapies will further extend the clinical benefits of ruxolitinib.
Microfluidic Concentration-Enhanced Cellular Kinase Activity Assay (2009)

In this paper, we reported a simple, disposable PDMS micro/nanofluidic preconcentration chip for in vitro concentration-enhanced cell kinase assays. Utilizing the preconcentration (electrokinetic trapping) directly from cell lysate (1 mM ATP) samples, we could achieve at least a 25-fold increase in reaction velocity and 65-fold enhancement in sensitivity. In addition, we shorten the assay time down to less than 10 min, with the sample volume requirements of down to approximately 5 cells. This device could be a generic and powerful tool for diagnostics and systems biology studies at the single-cell level, if properly optimized and integrated with the cell culture microdevices.