gebhart/patrepeval huggingface dataset:
Mouse <scp>TIGIT</scp> inhibits <scp>NK</scp>‐cell cytotoxicity upon interaction with <scp>PVR</scp> (2013)

The activity of natural killer (NK) cells is controlled by a balance of signals derived from inhibitory and activating receptors. TIGIT is a novel inhibitory receptor, recently shown in humans to interact with two ligands: PVR and Nectin2 and to inhibit human NK-cell cytotoxicity. Whether mouse TIGIT (mTIGIT) inhibits mouse NK-cell cytotoxicity is unknown. Here we show that mTIGIT is expressed by mouse NK cells and interacts with mouse PVR. Using mouse and human Ig fusion proteins we show that while the human TIGIT (hTIGIT) cross-reacts with mouse PVR (mPVR), the binding of mTIGIT is restricted to mPVR. We further demonstrate using surface plasmon resonance (SPR) and staining with Ig fusion proteins that mTIGIT binds to mPVR with higher affinity than the co-stimulatory PVR-binding receptor mouse DNAM1 (mDNAM1). Functionally, we show that triggering of mTIGIT leads to the inhibition of NK-cell cytotoxicity, that IFN-γ secretion is enhanced when mTIGIT is blocked and that the TIGIT-mediated inhibition is dominant over the signals delivered by the PVR-binding co-stimulatory receptors. Additionally, we identify the inhibitory motif responsible for mTIGIT inhibition. In conclusion, we show that TIGIT is a powerful inhibitory receptor for mouse NK cells.
Experiences of Using Intelligent Virtual Assistants by Visually Impaired Students in Online Higher Education (2019)

In today’s world, the attainment of higher education impacts the acquisition of competitive employment and, thus, quality of life. As a group, persons with disabilities continually fall behind others in such academic progress, requiring new efforts to support their earning of advanced credentials. Though highly beneficial for these individuals, obtaining a degree comes with elevated levels of stress. As enrollment of students with disabilities grows in all formats of higher education, those involved must understand the stress endured by these students and how to diminish it. Theories speculate that technology, such as intelligent virtual assistants, may be a viable tool for reducing such stress, thus increasing the completion of higher education by these individuals. A qualitative approach informed by three instruments—a questionnaire, an interview, and a journal entry—was utilized to examine this philosophy, focusing on the features used and for what purposes, the experiences had, and how this technology is used to mitigate disability-related stress. The research found that virtual assistants may assist in reducing the barriers and stress that often deter individuals with visual impairments from acquiring higher education, whether online or face-to-face. This technology was shown to increase the independence, autonomy, and social integration of these individuals while decreasing limitations. The fields of education and technology may use this evidence to optimize such benefits, thus increasing the use of virtual assistants by students with visual impairments and, subsequently, increasing their attainment of higher education and competitive employment.
MoSi<sub>2</sub>formation by rapid isothermal annealing (1982)

Formation of MoSi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> by rapid isothermal annealing has been investigated using black-body radiation from a graphite heater. Although elemental Mo layers deposited on 3 in diameter silicon wafers failed to form silicides after annealing, excellent results were obtained using co-sputtered Mo and Si on similar substrates. It was found that regrowth began within the first few seconds at 900-1000°C, and a 20 sec anneal time at 1000°C reduces sheet resistivity by one order of magnitude from as-deposited values. This method of annealing might thus offer a practical solution to low-resistivity silicide formation in very large-scale integrated-circuit devices, without the significant dopant redistribution observed in furnace annealing.
Off-Line Programming of Grinding Robots at Grohe Portugal (2016)

The work described in this paper address the problems of productivity of Grohe's Portugal grinding/ polishing department, related to the frequent stops of robotic cells for on-line programming and program adjustments. The solution to the stated problem was achieved through the adoption of off-line programming as an alternative to the conventional on-line method. Efforts were developed to overcome some limitations and restrictions found in terms of the software applications used, in order to adapt and improve their use to the needs of this type of contact applications. The solution developed is currently used for off-line programming the grinding robots at Grohe Portugal, with a significant reduction in the cells stop time to program the robots and also in the cycle time. The application of the off-line programming method and of the new programming techniques allowed to obtain a reduction of the cell stop time (up to 85% reduction), to optimize the production cycle time (up to 10% reduction) and, simultaneously, good results in terms of product finishing. The main limitations faced are the lack of realism of the wheel flexibility and the lack of sensitivity of the contact force with it.
A study of benign breast disease management based on clinical, radiological and pathological assessment (2022)

Benign breast disorders are usually hormone induced and therefore usually seen in the reproductive period of life with dramatic fall in incidence after menopause. As compared to breast cancers, benign breast lesions are 10 times more common. The aim of the study was to determine the spectrum and incidence of various benign breast diseases in female patients attending our institute and to compare the results with those of other studies. Material and methods: 80 cases of benign breast diseases which were clinically diagnosed and confirmed pathologically or radiologically were subjected for therapeutic interventions and the results were analysed. Results: In the present study of 80 cases, the age group most affected by benign breast diseases was 21-30 years. 63 patients (78.8 %) presented with lump in the breast and 23 patients’ common symptom is pain. In most of the cases of lump had duration between 7-12 months (38.8 %), pain for 1-5 days (13.8 %), discharge for 0-5 days (11.3 %). Both breasts were involved in 6 cases (7.5 %) whereas right and left breasts are equally involved in 47 cases each (46.25 %). Most of the patients were nulliparous (46.3 %) followed by multiparous (38.8 %) and uniparous (15.0 %). Fibroadenoma constituted in 53.8 % of patients (44 cases), breast abscess constituted 21.25 % (17 cases). The most commonly affected age group was 21-30 years. 63 patients (78.8 %) presented with lump in the breast and 23 patients presented with pain. HRUSG findings correlated with that of clinical diagnosis in 70 cases. 60 cases underwent core biopsy, and in 41 cases (68.33 %) there were fibroadenoma and 7 cases (11.66 %) fibro adenosis. 59 cases (73.75 %) underwent excision, and 18 cases (22.5 %) incision and drainage. Conclusion: The most common benign breast disease was fibroadenoma. Most common age group affected with benign breast disease was 21-30 years. 88.7 % of clinical diagnosis, 90.3 % of radiological diagnosis, 93.3 % of core needle biopsy diagnoses were correlating with the histopathology diagnosis
Photochromic Fused-Naphthopyrans without Residual Color (2012)

A series of new photochromic fused-naphthopyrans with an alkyl bridge between the pyran ring and the naphthalenic core was synthesized in several steps from 4-(bromomethyl)benzocoumarin. The presence of the alkyl bridge in these new fused-naphthopyrans prevents the formation of one long-lived photoisomer and therefore has a dramatic effect on their photochromic properties: UV irradiation of common naphthopyrans gives rise to two isomeric colored photoisomers, one of which fades very slowly and is responsible for a persistent residual color. UV excitation of these new uncolored fused-naphthopyrans leads to the formation of only one colored photoisomer that fades completely to the uncolored state in few seconds/minutes following a monoexponential decay law, thus avoiding the problem of the residual coloration typically observed with naphthopyrans.
Dew-Point Curves of Natural Gas. Measurement and Modeling (2006)

To achieve a reliable method to calculate the hydrocarbon dew point for natural gases in transmission, samples of natural gas were taken at the inlet of the Magreb-Europe pipeline in Spain. The composition up to the C12 fraction of each natural gas sample was determined by gas chromatography, and the dew-point curve was measured using a chilled mirror dew-point analyzer. In this work, we present the experimental measurements of dew points for six samples of natural gas between 1.1 × 105 Pa and 78.4 × 105 Pa in the temperature range from 235.2 to 277.9 K. The experimental results obtained were analyzed in terms of a predictive excess function−equation of state (EF-EOS) method based on the zeroth-approximation of Guggenheim's reticular model. Because the EF-EOS model uses a group contribution model, the availability of every binary experimental data corresponding to every binary interaction in the mixture is not necessary. Considering this and the good results obtained in previous studies, we concluded that the EF-EOS model could be used for proper prediction of the hydrocarbon, water, and water + methanol dew-points of real natural gases, even though binary experimental data for all components of the so-called C6+ fraction are not available. In this work, the capability of this theoretical model for the prediction of hydrocarbon dew points of the studied samples of natural gas is demonstrated within the studied temperature and pressure ranges. In fact, the model reproduces experimental dew-point temperature data within average absolute deviation between 0.4 and 3.0 K when two components are used for characterizing the composition of each heavy fraction of the samples of natural gas and from 1.6 to 2.3 K when all analyzed components are considered for each fraction.
<title>Gabor wavelet filters and fusion for distortion-invariant multiclass object detection</title> (1995)

Several different new Gabor wavelet filters are described: the Gabor transform (GT) filter consists of real, imaginary, and clutter filters; the Gabor basis function (GBF) filter uses a Gabor basis function for each training image; the morphological wavelet transform (MWT) filter includes a Gabor transform clutter map filter that locates clutter regions of a scene. These filters ar all shift-invariant and distortion-invariant. They are employed for detection: location of the positions of all object regions of interest (ROIs) in an input scene. Fusion of multiple filter outputs is used to reduce false alarms. This paper emphasizes the role for Gabor wavelet filters in detection and for producing a clutter map. Major emphasis is given to the final version of the Gabor wavelet clutter map portion of our MWT algorithm (this is our best detection algorithm). New detection and fusion results with a consistent database and thresholds are provided.
Cellular and humoral immune responses induced by intradermal or intramuscular vaccination with the major hepatitis B surface antigen (2000)

The vaccination route may influence the success of immunization against pathogens. The conventional intramuscular (i.m.) application of a vaccine containing the hepatitis B virus (HBV) surface antigen (HBsAg) led to protective anti-HBs antibody levels in the majority of vaccine recipients. In this study, we vaccinated healthy volunteers and a group of i.m. vaccine nonresponders via the intradermal (i.d.) route and analyzed the HBV-specific B-cell response as well as class-II- and class-I-restricted T-cell responses by (3)H-thymidine uptake, enzyme-linked immunosorbent assay (ELISA) and enzyme-linked immunospot assay (ELISPOT). The results were then compared with i.m. vaccinated controls. I.d. vaccinations were well tolerated and induced neutralizing anti-HBs antibodies in all naive vaccine recipients and, importantly, all but one former i.m. nonresponder developed protective anti-HBs serum antibody levels after 2 or 3 i.d. immunizations. On the cellular level, i.d. vaccine recipients showed significantly higher anti-HBs producing B-cell frequencies and more vigorous class-II-restricted T-helper (Th) cell responses than i.m. controls. However, although the HBsAg-specific T cells were characterized by their cytokine release as Th1-like cells in both groups, human leukocyte antigen (HLA)-A2+ individuals who received the soluble HBsAg via the i.d. route developed higher peptide-specific cytotoxic CD8+ T cell precursor (CTLp) frequencies. In conclusion, i.d. HBsAg vaccination is more effective even in former i.m. vaccine nonresponders with respect to antibody induction and specific B- and T-cell responses. The induction of virus-specific CTLp may provide the rationale to study the i.d. HBsAg vaccine in the treatment of chronic hepatitis B.
Cost-Sensitive Feature Selection of Numeric Data with Measurement Errors (2013)

Feature selection is an essential process in data mining applications since it reduces a model’s complexity. However, feature selection with various types of costs is still a new research topic. In this paper, we study the cost-sensitive feature selection problem of numeric data with measurement errors. The major contributions of this paper are fourfold. First, a new data model is built to address test costs and misclassification costs as well as error boundaries. It is distinguished from the existing models mainly on the error boundaries. Second, a covering-based rough set model with normal distribution measurement errors is constructed. With this model, coverings are constructed from data rather than assigned by users. Third, a new cost-sensitive feature selection problem is defined on this model. It is more realistic than the existing feature selection problems. Fourth, both backtracking and heuristic algorithms are proposed to deal with the new problem. Experimental results show the efficiency of the pruning techniques for the backtracking algorithm and the effectiveness of the heuristic algorithm. This study is a step toward realistic applications of the cost-sensitive learning.
In vivo measurement of pyridine nucleotide fluorescence from cat brain cortex (1976)

A modification of the methods is described which makes it possible to measure pyridine nucleotide fluorescence from the brain cortex in vivo without interference from movement and hemodynamic artifacts. Movement artifacts were eliminated by the use of a window technique. Fluorescence changes due to changes in hemoglobin oxygenation have been eliminated by measuring fluorescence at an isobestic wavelength of the hemoglobin-oxyhemoglobin reaction. The interference due to changes in red blood cell concentration has been studied by simultaneous measurements of fluorescence and ultraviolet reflection. Hemodilution revealed a linear relationship between the fluorescence from the pyridine nucleotide and reflected ultraviolet light. The ratio between the light absorption changes was approximately unity under the particular optical geometry employed in this study. This method has been used to measure fluorescence changes produced by nitrogen anoxia. The technique is discussed in relation to previous methods and the effects of anoxia are compared to previous findings.
Organic Bioelectronics (2007)

Abstract During the last two decades, organic electroactive materials have been explored as the working material in a vast array of electronic devices, promising low‐cost, flexible, and easily manufactured systems. The same materials also possess features that make them unique in bioelectronics applications, where electronic signals are translated into biosignals and vice versa. Here we review, in the broadest sense, the field of organic bioelectronics, describing the electronic properties and mechanisms of the organic electronic materials that are utilized in specific biological experiments.
The 4 Diepoxides of (R)-(+)-Limonene (1991)

The four diepoxides of limonene have been synthesized and separated, and their distinguishing spectral characteristics are described.
Interaction between Cdc42Hs and RhoGDI Is Mediated through the Rho Insert Region (1997)

Members of the Rho subfamily of GTP-binding proteins contain a region of amino acid sequence (residues 122-134) that is absent from other Ras-like proteins and is termed the Rho insert region. To address the functional role of this domain, we have constructed a Cdc42Hs/Ras chimera in which loop 8 from Ha-Ras was substituted for the region in Cdc42Hs that contains the 13-amino acid insert region. Our data indicate that the insert region of Cdc42Hs is not essential for its interactions with various target/effector molecules or for interactions with the guanine nucleotide exchange factor, Dbl, or the Cdc42 GTPase-activating protein (GAP). However, the regulation of GDP dissociation and GTP hydrolysis on Cdc42Hs by the Rho GDP-dissociation inhibitor (GDI) is extremely sensitive to changes in the insert region, such that a Cdc42Hs/Ha-Ras chimera that lacks this insert is no longer susceptible to a GDI-induced inhibition of GDP dissociation and GTP hydrolysis. The insensitivity to GDI activity is not due to the inability of the GDI molecule to bind to the Cdc42Hs/Ha-Ras chimera, and in fact, the GDI is fully capable of stimulating the release of this chimera from membranes.
Cancer Control Related to Stimulation of Immunity by Low-Dose Radiation (2007)

Previous studies showed that low dose radiation (LDR) could stimulate the immune system in both animal and human populations. This paper reviews the present status of relevant research as support to the use of LDR in clinical practice for cancer prevention and treatment. It has been demonstrated that radiation-induced changes in immune activity follows an inverse J-shaped curve, i.e., low dose stimulation and high dose suppression. The stimulation of immunity by LDR concerns most anticancer parameters, including antibody formation, natural killer activity, secretion of interferon and other cytokines as well as other cellular changes. Animal studies have revealed that LDR retards tumor growth, decreases cancer metastasis, and inhibits carcinogenesis induced by high dose radiation. These effects of LDR on cancer control were found to be related to its stimulation on immunity. The experimental data may well explain the efficacy of the clinical trial of LDR in the treatment of cancer.
Insights into glycan biosynthesis in chemically-induced hepatocellular carcinoma in rats: A glycomic analysis (2015)

The reported HCC-associated changes in glycan flow and subcellular localization explain the increase in high mannose glycans and siayl Lewis glycans common in HCC liver tissues.
MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia (2016)

We identified mutations in the IL7Ra gene or in genes encoding the downstream signaling molecules JAK1, JAK3, STAT5B, N-RAS, K-RAS, NF1, AKT and PTEN in 49% of patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL). Strikingly, these mutations (except RAS/NF1) were mutually exclusive, suggesting that they each cause the aberrant activation of a common downstream target. Expressing these mutant signaling molecules-but not their wild-type counterparts-rendered Ba/F3 cells independent of IL3 by activating the RAS-MEK-ERK and PI3K-AKT pathways. Interestingly, cells expressing either IL7Ra or JAK mutants are sensitive to JAK inhibitors, but respond less robustly to inhibitors of the downstream RAS-MEK-ERK and PI3K-AKT-mTOR pathways, indicating that inhibiting only one downstream pathway is not sufficient. Here, we show that inhibiting both the MEK and PI3K-AKT pathways synergistically prevents the proliferation of BaF3 cells expressing mutant IL7Ra, JAK and RAS. Furthermore, combined inhibition of MEK and PI3K/AKT was cytotoxic to samples obtained from 6 out of 11 primary T-ALL patients, including 1 patient who had no mutations in the IL7R signaling pathway. Taken together, these results suggest that the potent cytotoxic effects of inhibiting both MEK and PI3K/AKT should be investigated further as a therapeutic option using leukemia xenograft models.
On the development of photonic rf oscillators and resonant electro-optic modulators for advanced RF front-end applications (2011)

We present our recent results on the development of low-noise photonic RF oscillators as well as single sideband electro-optic modulators/mixers enabling novel photonic transmitters and receivers suitable for microwave applications, including phased array systems. In particular, we report on the study and the performance of an all-dielectric RF photonic receiver based on optical whispering gallery mode (WGM) resonator technology. We also discuss ultra-compact power-efficient opto-electronic oscillators based on high-Q WGM resonators. These devices, suitable for applications in systems requiring small size, weight, and power (SWaP), operate in a broad frequency range generating spectrally pure RF signals characterized with record low phase noise. An example of a tiny radar transmitter and receiver based on this technology is described.
Simultaneous gate and interconnect sizing for circuit-level delay optimization (1995)

Article Simultaneous gate and interconnect sizing for circuit-level delay optimization Share on Authors: Noel Menezes Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TXView Profile , Satyamurthy Pullela Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TXView Profile , Lawrence T. Pileggi Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TX Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, TXView Profile Authors Info & Claims DAC '95: Proceedings of the 32nd annual ACM/IEEE Design Automation ConferenceJanuary 1995 Pages 690–695https://doi.org/10.1145/217474.217612Online:01 January 1995Publication History 11citation265DownloadsMetricsTotal Citations11Total Downloads265Last 12 Months1Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access