gebhart/patrepeval huggingface dataset:
Performance of an improved bipolar membrane (2001)

This article deals with the conditions of the contacting interface between the cation-exchange and anion-exchange layers of a bipolar membrane. In particular details are given of the relationship which exists between the specific surface area and the performance of the bipolar membrane.
Click-crosslinkable and photodegradable gelatin hydrogels for cytocompatible optical cell manipulation in natural environment (2015)

This paper describes the generation of "click-crosslinkable" and "photodegaradable" gelatin hydrogels from the reaction between dibenzocycloctyl-terminated photoclevable tetra-arm polyethylene glycol and azide-modified gelatin. The hydrogels were formed in 30 min through the click-crosslinking reaction. The micropatterned features in the hydrogels were created by micropatterned light irradiation; the minimum resolution of micropatterning was 10-μm widths for line patterns and 20-μm diameters for circle patterns. Cells were successfully encapsulated in the hydrogels without any loss of viability across a wide concentration range of crosslinker. In contrast, an activated-ester-type photocleavable crosslinker, which we previously used to prepare photodegradable gelatin hydrogels, induced a decrease in cell viability at crosslinker concentrations greater than 1.8 mM. We also observed morphology alteration and better growth of cancer cells in the click-crosslinked photodegradable gelatin hydrogels that included matrigel than in the absence of matrigel. We also demonstrated micropatterning of the hydrogels encapsulating cells and optical cell separation. Both of the cells that remained in the non-irradiated area and the cells collected from the irradiated area maintained their viability.
Parathyroid Origin of a New Circulating Hypertensive Factor in Spontaneously Hypertensive Rats (1989)

The parathyroid gland has been causally associated with some forms of hypertension, yet parathyroid hormone (PTH) has been shown to possess hypotensive properties. Recently, we described the presence of a circulating hypertensive factor in spontaneously hypertensive rat (SHR) plasma, the expression of which is associated with a novel cell type in the parathyroid gland. In order to determine whether this hypertensive factor might be produced by the parathyroid gland, the effects of parathyroidectomy and parathyroid transplantation on mean arterial pressure (MAP) and hypertensive factor activity were studied. Parathyroidectomy, but not sham operation, decreased MAP in SHR and resulted in the disappearance of the hypertensive factor from the plasma. Transplantation of SHR parathyroid glands into Sprague-Dawley (SD) rats resulted in an increase in MAP and the appearance of the factor in the plasma, whereas transplantation of SD parathyroid glands into SHR had exactly the opposite effect. SD to SD transplantation had no effect on MAP or hypertensive factor activity. Infusions of PTH gave opposite effects to hypertensive factor infusions. These results suggest that the hypertensive factor is parathyroid gland-dependent but is not PTH. On this basis, we have proposed that the factor be referred to as "Parathyroid Hypertensive Factor," or "PHF."
Polymers of Higher Olefins (2005)

Abstract This article describes polymeric materials derived from higher olefins, α‐olefins with carbon atom numbers 4 and higher, and from cycloolefins. Both higher α‐olefins and cycloolefins can produce homopolymers and copolymers with lighter olefins, mostly with ethylene. Crystalline polymers of higher α‐olefins belong to two classes of stereoregular polymers, isotactic and syndiotactic. Isotactic polymers are produced with two types of catalysts, heterogeneous Ziegler–Natta catalysts and some bridged metallocene catalysts. Other types of metallocene catalysts produce either crystalline syndiotactic polymers or amorphous atactic polymers. Higher α‐olefins can also be polymerized with cationic initiators to amorphous oligomeric materials. Cycloolefins are polymerized via two different mechanisms: the ring‐opening metathesis reaction catalyzed with tungsten, ruthenium, or molybdenum compounds, and polymerization reactions without cycle opening catalyzed with metallocene complexes. Several types of polymers and copolymers of higher α‐olefins and cycloolefins are produced commercially: Isotactic crystalline poly(1‐butene) (PB) and poly(4‐methyl‐1‐pentene) (PMP). Oligomers of linear α‐olefins, viscous liquids. Copolymers of cycloolefins, such as cyclopentene or norbornene, and ethylene, tough amorphous transparent plastics. Polymers of cycloolefins, poly(dicyclopentadiene), poly(cyclooctene), and poly(norbornene). Copolymers of higher α‐olefins with ethylene containing from 6 to 50 wt% of higher α‐olefins. Due to high commercial significance of these materials, they are described in a separate article, “Polyethylene, Linear Low Density”. Crystalline PB is used to manufacture pipe, tubing, and blown film. Crystalline PMP is a highly transparent plastic. It is used for the manufacture of medical equipment, chemical laboratory equipment, and a variety of injection‐molded articles. Liquid oligomers of higher linear α‐olefins produced with cationic initiators have found wide applications as base oils in the formulation of various industrial lubricants. They are used in synthetic lubricating oils for cars, transformer oils, transmission and crankcase fluids, etc. Copolymers of cycloolefins and ethylene are amorphous materials with high glass points. They are used as transparent specialty plastics with high toughness. Polymer of cyclooctene is an elastic material of low crystallinity; it is mostly used as a component in rubber, poly (vinyl chloride) (PVC)‐ and poly (styrene) (PS)‐based compositions. Cured liquid‐molding resins based on poly(dicyclopentadiene) are used for the manufacture of automotive parts for trucks, snowmobiles, wheel loaders, and recreational vehicles.
A wearable RF sensor on fabric substrate for pulmonary edema monitoring (2017)

We propose a radio frequency (RF) sensor built on a fabric textile substrate for pulmonary edema monitoring. The 37-port RF sensor is designed and optimized to operate at 60 MHz with a low input power of 1 mW. By applying the least squares (LS) method, an equation was obtained for dielectric constant estimation using the transmission coefficient of each RF sensor port. The simulated errors are estimated for normal lung, edema and emphysema infected lung cases using a human chest model with an average error of 0.57%. Inkjet printing of the proposed design is then discussed.
Distillate fuels containing monoalkyl substitution derivatives of thiadiazoles (1990)

This patent describes a distillate fuel composition. It comprises: a major amount of gasoline and a minor amount of a mono alkyl substituted derivative of a thiadiazole.
Evaluation of ERG responsive proteome in prostate cancer (2013)

This study delineates the global proteome for prostate tumors stratified by ERG expression status. The ERP data confirm the functions of ERG in inhibiting cell differentiation and activating cell growth, and identify potentially novel biomarkers and therapeutic targets.
Spectroscopic Sorting of Aerosols by a Compact Sensor Employing UV LEDs (2006)

A compact sensor for physically sorting bioaerosols based on fluorescence spectra from single particles excited using arrays of ultraviolet light emitting diodes (UV LEDs) is presented. The optical system integrates electronics for real-time processing of spectral data and a miniaturized aerodynamic deflector for particle separation. Fluorescent polystyrene latex spheres are used to demonstrate fluorescence collection on-the-fly, operation of a real-time spectral algorithm, and physical separation of individual particles. This sensor illustrates the utility of recently developed UV LEDs, in conjunction with novel optical design and custom electronics, to shrink the size of aerosol fluorescence detection systems.
A flexible view ordering technique for high‐quality real‐time 2DFT MR fluoroscopy (1999)

A method to tailor the view order to the reconstruction cycle is introduced for real-time MRI. It is well known that view sharing and oversampling central k-space views can improve the temporal resolution of gradient-echo pulse sequences. By ordering phase-encodes to synchronize k-space acquisition with the reconstruction cycle, apparent temporal resolution can match the frame rate with as few as one-fourth of the phase-encodes sampled per reconstruction. Spatial resolution is maintained by periodically updating high spatial frequencies. In addition to apparent temporal resolution, three other criteria for real-time imaging are identified and evaluated: display latency, dispersion, and frame-to-frame consistency. Latency is minimized by ordering views in a reverse-centric manner within each reconstruction interval, sampling high-energy views immediately prior to beginning reconstruction. Dispersion is kept low and consistent by synchronizing acquisition and reconstruction, thus avoiding poorly timed reconstruction instances. Real-time implementation demonstrates pulsatile time-of-flight blood signal enhancement in humans. Magn Reson Med 42:69–81, 1999. © 1999 Wiley-Liss, Inc.
Creation of a Fully Functional Human Chimeric DNA Repair Protein (1998)

A dose-limiting toxicity of certain chemotherapeutic alkylating agents is their toxic effects on nontarget tissues such as the bone marrow. To overcome the myelosuppression observed by chemotherapeutic alkylating agents, one approach is to increase the level of DNA repair proteins in hematopoietic stem and progenitor cells. Toward this goal, we have constructed a human fusion protein consisting of O6-methylguanine DNA methyltransferase coupled with an apurinic endonuclease, resulting in a fully functional protein for both O6-methylguanine and apurinic/apyrimidinic (AP) site repair as determined by biochemical analysis. The chimeric protein protected AP endonuclease-deficient Escherichia coli cells against methyl methanesulfonate and hydrogen peroxide (H2O2) damage. A retroviral construct expressing the chimeric protein also protected HeLa cells against 1,3-bis(2-chloroethyl)-1-nitrosourea and methyl methanesulfonate cytotoxicity either when these agents were used separately or in combination. Moreover, as predicted from previous analysis, truncating the amino 150 amino acids of the apurinic endonuclease portion of the O6-methylguanine DNA methyltransferase-apurinic endonuclease protein resulted in the retention of O6-methylguanine DNA methyltransferase activity but loss of all AP endonuclease activity. These results demonstrate that the fusion of O6-methylguanine DNA methyltransferase and apurinic endonuclease proteins into a combined single repair protein can result in a fully functional protein retaining the repair activities of the individual repair proteins. These and other related constructs may be useful for protection of sensitive tissues and, therefore, are candidate constructs to be tested in preclinical models of chemotherapy toxicity.
Toward fast reliable communication at rates near capacity with Gaussian noise (2010)

For the additive Gaussian noise channel with average codeword power constraint, sparse superposition codes and adaptive successive decoding is developed. Codewords are linear combinations of subsets of vectors, with the message indexed by the choice of subset. A feasible decoding algorithm is presented. Communication is reliable with error probability exponentially small for all rates below the Shannon capacity.
Structure of the Ca<sup>2+</sup>/S100B/NDR Kinase Peptide Complex:  Insights into S100 Target Specificity and Activation of the Kinase (2003)

NDR, a nuclear serine/threonine kinase, belongs to the subfamily of Dbf2 kinases that is critical to the morphology and proliferation of cells. The activity of NDR kinase is modulated in a Ca(2+)/S100B-dependent manner by phosphorylation of Ser281 in the catalytic domain and Thr444 in the C-terminal regulatory domain. S100B, which is a member of the S100 subfamily of EF-hand proteins, binds to a basic/hydrophobic sequence at the junction of the N-terminal regulatory and catalytic domains (NDR(62-87)). Unlike calmodulin-dependent kinases, regulation of NDR by S100B is not associated with direct autoinhibition of the active site, but rather involves a conformational change in the catalytic domain triggered by Ca(2+)/S100B binding to the junction region. To gain further insight into the mechanism of activation of the kinase, studies have been carried out on Ca(2+)/S100B in complex with the intact N-terminal regulatory domain, NDR(1-87). Multidimensional heteronuclear NMR analysis showed that the binding mode and stoichiometry of a peptide fragment of NDR (NDR(62-87)) is the same as for the intact N-terminal regulatory domain. The solution structure of Ca(2+)/S100B and NDR(62-87) has been determined. One target molecule is found to associate with each subunit of the S100B dimer. The peptide adopts three turns of helix in the bound state, and the complex is stabilized by both hydrophobic and electrostatic interactions. These structural studies, in combination with available biochemical data, have been used to develop a model for calcium-induced activation of NDR kinase by S100B.
Measurement and empirical equation of critical stresses for slip generation from oxide precipitates in silicon wafers (2018)

The behavior of slip dislocations generated from oxide precipitates or bulk microdefects (BMDs) in Czochralski silicon wafers with different BMD sizes and oxygen concentrations has been studied using three-point bending tests at high temperatures (700–850 °C). We have developed a method of measuring critical stresses for slip generation caused by BMD growth. It has been found that not only the locking effect of residual oxygen on dislocations but also other factors such as BMD size are important for critical stress to generate and mobilize slip dislocations on {111} crystallographic planes, especially in high temperature ranges. An empirical equation for the estimation of the critical stress has also been produced using a simple model and the experimental results obtained in this study. The formulation enables us to accurately estimate the behavior of slip deformation under various thermal stress conditions.
Angiopoietin-like 4 Interacts with Matrix Proteins to Modulate Wound Healing* (2010)

A dynamic cell-matrix interaction is crucial for a rapid cellular response to changes in the environment. Appropriate cell behavior in response to the changing wound environment is required for efficient wound closure. However, the way in which wound keratinocytes modify the wound environment to coordinate with such cellular responses remains less studied. We demonstrated that angiopoietin-like 4 (ANGPTL4) produced by wound keratinocytes coordinates cell-matrix communication. ANGPTL4 interacts with vitronectin and fibronectin in the wound bed, delaying their proteolytic degradation by metalloproteinases. This interaction does not interfere with integrin-matrix protein recognition and directly affects cell-matrix communication by altering the availability of intact matrix proteins. These interactions stimulate integrin- focal adhesion kinase, 14-3-3, and PKC-mediated signaling pathways essential for effective wound healing. The deficiency of ANGPTL4 in mice delays wound re-epithelialization. Further analysis revealed that cell migration was impaired in the ANGPTL4-deficient keratinocytes. Altogether, the findings provide molecular insight into a novel control of wound healing via ANGPTL4-dependent regulation of cell-matrix communication. Given the known role of ANGPTL4 in glucose and lipid homeostasis, it is a prime therapeutic candidate for the treatment of diabetic wounds. It also underscores the importance of cell-matrix communication during angiogenesis and cancer metastasis.
Robust latch mapping for combinational equivalence checking (2002)

Article Free Access Share on Robust latch mapping for combinational equivalence checking Authors: Jerry R. Burch Cadence Berkeley Labs Cadence Berkeley LabsView Profile , Vigyan Singhal Cadence Berkeley Labs Cadence Berkeley LabsView Profile Authors Info & Claims ICCAD '98: Proceedings of the 1998 IEEE/ACM international conference on Computer-aided designNovember 1998 Pages 563–569https://doi.org/10.1145/288548.289087Published:01 November 1998Publication History 11citation233DownloadsMetricsTotal Citations11Total Downloads233Last 12 Months19Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A novel multi-input floating-gate MOS four-quadrant analog multiplier (1996)

A novel four-quadrant analog multiplier using multi-input floating-gate MOS (MFMOS) transistors has been designed and fabricated using a 2-/spl mu/m double-poly double-metal P-well CMOS process. It is essentially based on the quarter-square technique which relies on the square-law characteristic of the MOS transistor in the saturation region. The multiplier is realized with only four MFMOS transistors and a current source. The input range is 100% of the supply voltage and accepts either differential, single-ended, or floating input signals. Measured nonlinearity and total harmonic distortion are 0.2% and 0.5%, respectively, under full scale input conditions. Input noise is 170 /spl mu/V (rms), giving a 95 dB input dynamic range. The power dissipation is 1.1 mW and bandwidth is 12 MHz. Second-order effects on the multiplier performance have also been analyzed.
Laser illumination for manipulation of hydrogen charge states in silicon solar cells (2014)

This Letter investigates the important parameters of illumination for control of hydrogen charge states in p-type silicon solar cells. Through variations in the wavelength and intensity of illumination, evidence is provided for the importance of the neutral charge state of interstitial hydrogen, H0, for the passivation of defects in upgraded metallurgical grade (UMG) silicon. It is shown that through this approach minority carrier lifetimes may be achieved in excess of those realised through previous techniques, resulting in open-circuit voltages (iVOC) over 710 mV. (© 2015 WILEY-VCH Verlag GmbH &Co. KGaA, Weinheim)
Dual inhibition of ErbB1 and ErbB2 in cancer by recombinant human prolidase mutant hPEPD-G278D (2016)

ErbB1 and ErbB2 are oncogenic cell surface receptor tyrosine kinases, linked to many forms of human cancer, and are major cancer therapeutic targets. Many lines of evidence indicate that targeting ErbB1 and ErbB2 is an important cancer therapeutic approach. We recently found that a recombinant enzymatically-inactive mutant of human prolidase, i.e., hPEPD-G278D, is an inhibitory ligand of ErbB2 and strongly inhibits ErbB2-overexpressing cells in vitro and in vivo. hPEPD-G278D also binds to ErbB1. Here, we show that hPEPD-G278D binds to ErbB1 with high affinity, initially activating ErbB1 but later silencing it, and that deletion of subdomain 2 in ErbB1 extracellular domain abolishes the binding. The proliferation of ErbB1-overexpressing cells is strongly inhibited by hPEPD-G278D, regardless of ErbB2 expression or cell type, whereas cells lacking ErbB1 and ErbB2 are insensitive to it. In contrast, EGF, another ErbB1 ligand, either stimulates or mildly inhibits cell proliferation. Moreover, hPEPD-G278D treatment of mice bearing ErbB1-overexpressing tumors leads to tumor regression, which is accompanied by down regulation and decreased phosphorylation of ErbB1 and ErbB2 as well as decreased phosphorylation of downstream signaling molecules and activation of apoptosis in the tumor tissues. We conclude that hPEPD-G278D is a dual inhibitor of ErbB1 and ErbB2 and selectively targets cancer cells overexpressing ErbB1 and/or ErbB2. Moreover, our finding that both receptors are silenced in cancer cells by hPEPD-G278D highlights an unusual consequence of ligand-receptor interaction.
55.1: Stressed Liquid Crystals for Electrically Controlled Fast Shift of Phase Retardation (2003)

Abstract We developed stressed liquid crystal (SLCs) films consisting of unidirectionally oriented domains of liquid crystal separated with polymer chains for use in electrically controlled phase retardation devices. Performance of this new electro‐optical material makes them an ideal candidate for use in high‐speed displays, light modulators, and beam steering devices.
Diversified ranking on large graphs (2011)

Diversified ranking on graphs is a fundamental mining task and has a variety of high-impact applications. There are two important open questions here. The first challenge is the measure - how to quantify the goodness of a given top-k ranking list that captures both the relevance and the diversity? The second challenge lies in the algorithmic aspect - how to find an optimal, or near-optimal, top-k ranking list that maximizes the measure we defined in a scalable way? In this paper, we address these challenges from an optimization point of view. Firstly, we propose a goodness measure for a given top-k ranking list. The proposed goodness measure intuitively captures both (a) the relevance between each individual node in the ranking list and the query; and (b) the diversity among different nodes in the ranking list. Moreover, we propose a scalable algorithm (linear wrt the size of the graph) that generates a provably near-optimal solution. The experimental evaluations on real graphs demonstrate its effectiveness and efficiency.
Minimizing the electrical losses on the front side: Development of a selective emitter process from a single diffusion (2008)

In this paper we present latest results in the development of a process for the fabrication of a selective emitter structure on mono- and multicrystalline silicon solar cells. The process is based on an approach that was first introduced by Zerga et al. [1]. We have chosen a wet chemical route for an emitter etch back where the areas of the wafer that are intended for emitter metallization are shielded from etching by a screen printable etch barrier. The etch barrier is later removed by wet chemical etching. The process has yielded a gain in open circuit voltage of more than 1% and a gain in short circuit current of more than 2%. The overall efficiency gain was more than 0.3% <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">abs</inf> due to slightly lower fill factor of the cells.