gebhart/patrepeval huggingface dataset:
Length of Individual Apnea Events Is Increased by Supine Position and Modulated by Severity of Obstructive Sleep Apnea (2016)

Positional obstructive sleep apnea (OSA) is common among OSA patients. In severe OSA, the obstruction events are longer in supine compared to nonsupine positions. Corresponding scientific information on mild and moderate OSA is lacking. We studied whether individual obstruction and desaturation event severity is increased in supine position in all OSA severity categories and whether the severity of individual events is linked to OSA severity categories. Polygraphic recordings of 2026 patients were retrospectively analyzed. The individual apnea, and hypopnea durations and desaturation event depth, duration, and area of 526 included patients were compared between supine and nonsupine positions in different OSA severity categories. Apnea events were 6.3%, 12.5%, and 11.1% longer (p < 0.001) in supine compared to nonsupine position in mild, moderate, and severe OSA categories, respectively. In moderate and severe OSA categories desaturation areas were 5.7% and 25.5% larger (p < 0.001) in supine position. In both positions the individual event severity was elevated along increasing OSA severity category (p < 0.05). Supine position elevates apnea duration in all and desaturation area in moderate and severe OSA severity categories. This might be more hazardous for supine OSA patients and therefore, estimation of clinical severity of OSA should incorporate also information about individual event characteristics besides AHI.
Evaluation of common RF coil setups for MR imaging at ultrahigh magnetic field (2011)

This study is an evaluation of the ratio of electric field to magnetic field (E/B<sub>1</sub>), specific absorption rate (SAR) and signal-to-noise ratio (SNR) generated by three different RF transceiver coil setups: surface coil, surface coil with shielding, and microstrip using a finite discrete time domain (FDTD) simulation in the presence of a head phantom. One of our main focuses in this study is to better understand coil designs that would improve patient safety at high fields by studying a coil type that may potentially minimize SAR while examining potential changes in SNR. In the presence of a human head load, the microstrip's E/B<sub>1</sub> ratio was on average smallest while its SAR was also on average smallest of the three setups, suggesting the microstrip may be a better RF coil choice for MRI concerning patient safety and parallel excitation applications than the other two coils. In addition, the study suggests that the microstrip also has a higher SNR compared with the other two coils demonstrating the possibility that the microstrip could lead to higher quality MRI images.
Spatial mapping of the internal and external electromagnetic fields of negative index metamaterials (2006)

We perform an experimental study of the phase and amplitude of microwaves interacting with and scattered by two-dimensional negative index metamaterials. The measurements are performed in a parallel plate waveguide apparatus at X-band frequencies (8-12 GHz), thus constraining the electromagnetic fields to two dimensions. A detection antenna is fixed to one of the plates, while a second plate with a fixed source antenna or waveguide is translated relative to the first plate. The detection antenna is inserted into, but not protruding below, the stationary plate so that fields internal to the metamaterial samples can be mapped. From the measured mappings of the electric field, the interplay between the microstructure of the metamaterial lattice and the macroscopic averaged response is revealed. For example, the mapped phase fronts within a metamaterial having a negative refractive index are consistent with a macroscopic phase-in accordance with the effective medium predictions-which travels in a direction opposite to the direction of propagation. The field maps are in excellent agreement with finite element numerical simulations performed assuming homogeneous metamaterial structures.
Microinjected U snRNAs are imported to oocyte nuclei via the nuclear pore complex by three distinguishable targeting pathways. (1992)

The inhibitory effects of wheat germ agglutinin and mAb 414 on the nuclear import of all types of U snRNAs indicate that they cross the nuclear envelope through the nuclear pore complex. However, the import of different U snRNAs occurs by kinetically distinct targeting pathways that can be distinguished from one another by the competitive effects of free trimethylguanosine cap dinucleotide (m3GpppG) and P(Lys)-BSA, an efficient synthetic karyophile based on the nuclear localization signal of SV40 large T antigen. The import of U snRNAs that contain 5' m3GpppN caps and are complexed by Sm proteins (U1, U2, U4, and U5) is competed by coinjection with free m3GpppG, indicating a shared transport factor, but not by P(Lys)-BSA. The import of U6 snRNA, which lacks a m3GpppN cap and is not complexed by the Sm proteins, is competed by P(Lys)-BSA but not by free m3GpppG. Thus, by the criterion of kinetic competition, U6 snRNA import is identical to that of the karyophilic proteins P(Lys)-BSA and nucleoplasmin. Uniquely, the import of U3 snRNA, which contains a m3GpppN cap but does not bind Sm proteins is not competed by either free m3GpppG or P(Lys)-BSA. Thus, U3 snRNA appears to be imported by a novel third kinetic pathway.
A Class of Local Centroid Algorithms for Classification and Quantization in Spaces of Arbitrary Dimension (1983)

A Class of Local Centroid Algorithms for Classification and Quantization in Spaces of Arbitrary Dimension
A methodology for the test of embedded compiled cells (2003)

The use of compilers for structured cells such as RAMs, ROMs, multipliers and PLAs (programmable logic arrays) has become widespread in the design of application-specific integrated circuits (ASICs). The authors present a methodology for testing circuits made from these compiled cells. The key elements of this methodology are the vector compilers that generate test suites for the compiled cells and an isolation strategy that allows these test suites to be applied to embedded functional blocks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Electromagnetic Analysis Perturbation using Chaos Generator (2016)

Cryptographic algorithms albeit mathematically sure may have security breaches when implemented on hardware chips. There are several ways to compromise their security, one method is to analyze their electromagnetic (EM) emissions in order to find secrets (cryptographic keys for example). This paper proposes a proof of concept of a countermeasure against these attacks, it is based on a chaotic oscillator coupled with an antenna to blur the EM emissions of the chip. The objective is to generate EM noise within the chip with an internal system in order to make the secret information harder to extract. A testchip was developed and tested in conditions as close as possible to real usecase to prove the relevance of the concept. The EM field collected while running the chip were superposed to AES (Advanced Encryption Standard) emissions collected using a similar setup to test the disturbing effect of the noise on a CPA, a classic attack to retrieve AES keys. The experiment shows that it can effectively increase the difficulty of finding the keys, proving that the basic concept and the developed chip can be used as a countermeasure for EM analysis attacks.
Development and implementation of a novel immune thrombocytopenia bleeding score for dogs (2018)

The DOGiBAT and assessment quiz are simple tools to standardize evaluation of bleeding severity. With further validation, the DOGiBAT may provide a clinically relevant metric to characterize ITP severity and monitor response in treatment trials.
Optimal configuration for BGP route selection (2003)

An Internet Service Provider must provide transit service for traffic between its customers and its providers and, at the same time, attempt to minimize network utilization and balance traffic according to the capacities of its border routers. Central to the selection of border routers for transit traffic flows is the Border Gateway Protocol (BGP) between Autonomous System (AS) peers, through which route advertisements for network prefixes determine the selection of border routers for each traffic flow. This paper examines the problem of determining an optimal set of border routers for the advertisement of network prefixes so as to minimize the cost of traffic across a transit service provider's network while maintaining egress bandwidth constraints at the border routers. Egress bandwidth constraints are considered because there is anecdotal evidence to suggest that the peering links between ASs are often bottleneck links in the Internet, and so the optimal utilization of these links is also critical. After precisely formulating the optimization problem in accordance with the operation of BGP, we relate the problem to the generalized assignment problem and develop heuristic solutions for solving it. Simulation results from an implementation show up to a 37% improvement in the utilization of the peering links when compared to hot potato routing.
Clinical status before and during cardiopulmonary resuscitation versus outcome in two consecutive databases (1995)

The outcome of out-of-hospital cardiac arrest is very much determined by uncontrollable precardiopulmonary resuscitation (CPR) conditions. Two consecutively registered databases containing variables related to pre-arrest, arrest and CPR are similarly analysed to produce and validate a simple clinical algorithm for acute decision making during CPR. The outcome results in the two different time periods remained nearly unchanged. The simultaneous and persistent absence of ventricular fibrillation, gasping and light-reactive pupils after arrival of the second tier was strongly associated with a poor outcome. Unresponsiveness of these variables to a full and optimal trial of advanced life support can in itself be considered as an index for irreversible myocardial and neurological damage.
Comparison of Physiological Motion Filters for <i>In Vivo</i> Cardiac ARFI (2011)

Acoustic radiation force impulse (ARFI) imaging is being utilized to investigate mechanical properties ofcardiac tissue. The underlying physiological motion, however, presents a major challenge. This paper aims to investigate the effectiveness of various physiological motion filters using in vivo canine data with a simulated ARFI push pulse. Ideally, the motion filter will exactly model the physiological motion and, when subtracted from the total displacement, leave only the simulated ARFI displacement profile. We investigated three temporal quadratic motion filters: (1)interpolation, (2) extrapolation and (3) a weighted technique. Additionally, the various motion filters were compared when using 1-D versus 2-D autocorrelation methods to estimate motion. It was found that 2D-autocorrelation always produced better physiological motion estimates regardless of the type of filter used. The extrapolation filter gives the most accurate estimate of the physiological motion at times immediately after the ARFI push (0.1 ms) while a close-time interpolation filter using displacement estimates at times before full tissue recovery gives the most accurate estimates at later times after the ARFI push (0.7 ms). While improvements to the motion filter during atrial systole and the onset of ventricular systole are needed, the weighted, close-time interpolation and extrapolation motion filters all offer promising results for estimating cardiac physiological motion more accurately, while allowing faster ARFI frame rates than previous motion filters. This study demonstrates the ability to eliminate physiological motion in a clinically-feasible manner, opening the door for more extensive clinical experimentation.
Stem Cells Handbook (2004)

After decades of intense experimental work by a number of different investigators, it is now clearly recognized that the ability of stem cells to give rise to broad variety of differentiated cell types is critical not only to the emergence of new and more effective treatments for human diseases, but also to understanding the pathogenesis of congenital abnormalities and cancer. In Stem Cells Handbook, leading scientists in the field survey the "state-of-the-science" of stem cell biology, explaining the origin of stem cells, and describing how they function, how they can cause illness, and how they might be employed to cure or ameliorate disease. In particular, the authors discuss the roles of stem cells in development and organogenesis, in normal tissue turnover, in the repair response to injury, and in carcinogenesis. They also explain how to obtain stem cells from different organs, culture them in vitro, and manipulate them for therapeutic use. The book highlights the promise of using embryonic and adult tissue stem cells in both animal models and human diseases for the replacement of damaged tissue, for the treatment of cancer, for cell replacement, and for gene therapy treatments of genetic and metabolic diseases. Comprehensive and authoritative, Stem Cells Handbook not only critically reviews and summarizes the diverse studies now being carried out on this highly promising class of cells, but also constitutes every investigator's gold-standard reference on stem cell biology and medicine today
Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies (2017)

Natural compounds from various plants, microorganisms and marine species play an important role in the discovery novel components that can be successfully used in numerous biomedical applications, including anticancer therapeutics. Since uncontrolled and rapid cell division is a hallmark of cancer, unraveling the molecular mechanisms underlying mitosis is key to understanding how various natural compounds might function as inhibitors of cell cycle progression. A number of natural compounds that inhibit the cell cycle arrest have proven effective for killing cancer cells in vitro, in vivo and in clinical settings. Significant advances that have been recently made in the understanding of molecular mechanisms underlying the cell cycle regulation using the chemotherapeutic agents is of great importance for improving the efficacy of targeted therapeutics and overcoming resistance to anticancer drugs, especially of natural origin, which inhibit the activities of cyclins and cyclin-dependent kinases, as well as other proteins and enzymes involved in proper regulation of cell cycle leading to controlled cell proliferation.
Tensor field design in volumes (2017)

3D tensor field design is important in several graphics applications such as procedural noise, solid texturing, and geometry synthesis. Different fields can lead to different visual effects. The topology of a tensor field, such as degenerate tensors, can cause artifacts in these applications. Existing 2D tensor field design systems cannot be used to handle the topology of a 3D tensor field. In this paper, we present to our knowledge the first 3D tensor field design system. At the core of our system is the ability to edit the topology of tensor fields. We demonstrate the power of our design system with applications in solid texturing and geometry synthesis.
Recombination at the interface between silicon and stoichiometric plasma silicon nitride (2002)

The injection level dependence of the effective surface recombination velocity (Seff) for the interface between crystalline silicon and stoichiometric silicon nitride, prepared by high-frequency direct plasma enhanced chemical vapour deposition (PECVD), has been comprehensively studied. A wide variety of substrate resistivities for both n-type and p-type dopants have been investigated for minority carrier injection levels (Δn) between 1012 and 1017 cm-3. Effective lifetimes of 10 ms have been measured for high resistivity n-type and p-type silicon, the highest ever measured for silicon nitride passivated wafers, resulting in Seff values of 1 cm s-1 being unambiguously determined. The Seff(Δn) dependence is shown to be constant for n-type silicon under low injection conditions, while for p-type silicon, there is a clear minimum to Seff for injection levels close to the doping density. Further, the Seff(Δn) dependence for these stoichiometric silicon nitride films appears to be weaker than that for other high-quality, silicon-rich silicon nitride films prepared by remote PECVD.
Plasticity of inhibitory synaptic network interactions in the lateral amygdala upon fear conditioning in mice (2007)

After fear conditioning, plastic changes of excitatory synaptic transmission occur in the amygdala. Fear-related memory also involves the GABAergic system, although no influence on inhibitory synaptic transmission is known. In the present study we assessed the influence of Pavlovian fear conditioning on the plasticity of GABAergic synaptic interactions in the lateral amygdala (LA) in brain slices prepared from fear-conditioned, pseudo-trained and naïve adult mice. Theta-burst tetanization of thalamic afferent inputs to the LA evoked an input-specific potentiation of inhibitory postsynaptic responses in projection neurons; the cortical input was unaffected. Philanthotoxin (10 microM), an antagonist of Ca2+-permeable AMPA receptors, disabled this plastic phenomenon. Surgical isolation of the LA, extracellular application of a GABA(B) receptor antagonist (CGP 55845A, 10 microM) or an NMDA receptor antagonist (APV, 50 microM), or intracellular application of BAPTA (10 mM), did not influence the plasticity. The plasticity also showed as a potentiation of monosynaptic excitatory responses in putative GABAergic interneurons. Pavlovian fear conditioning, but not pseudo-conditioning, resulted in a significant reduction in this potentiation that was evident 24 h after training. Two weeks after training, the potentiation returned to control levels. In conclusion, a reduction in potentiation of inhibitory synaptic interactions occurs in the LA and may contribute to a shift in synaptic balance towards excitatory signal flow during the processes of fear-memory acquisition or consolidation.
Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption. (1994)

Autocrine products of osteoclasts such as interleukin-6 may play an important role in normal osteoclast formation and activity. To identify novel stimulatory factors for osteoclasts, we have prepared a mammalian cDNA expression library generated from highly purified human osteoclast-like multinucleated cells (MNC) formed in long term bone marrow cultures and screened this library for autocrine factors that enhance MNC formation. A candidate clone which stimulated MNC formation was isolated. Sequence analysis showed that this cDNA encoded annexin II (AXII). Purified recombinant AXII significantly increased MNC formation in human bone marrow cultures in the absence of 1,25-(OH)2 vitamin D3 and enhanced MNC formation in mouse bone marrow cultures treated with 10(-9) M 1,25-(OH)2 vitamin D3. The enhanced MNC formation in murine marrow cultures resulted in increased bone resorption. Treatment of fetal rat long bones with AXII and 1,25-(OH)2 vitamin D3 significantly increased bone resorption compared to 1,25-(OH)2 vitamin D3 alone. Reverse transcriptase polymerase chain reaction analysis demonstrated that AXII mRNA was expressed at high levels in RNA isolated from highly purified giant cells from osteoclastomas, human osteoclast-like MNC, and pagetic bone. Western blot analysis of conditioned media collected from human marrow cultures showed that AXII was present in the media. Furthermore, approximately 50% of total AXII produced by cells transfected with AXII cDNA was present in the conditioned media. These data suggest that the AXII is an autocrine factor that enhances osteoclast formation and bone resorption and demonstrate a previous unknown function for AXII.
Growth in Epithelial Cell Proliferation and Apoptosis Correlates Specifically to the Inflammation Activity of Inflammatory Bowel Diseases: Ulcerative Colitis Shows Specific p53- and EGFR Expression Alterations (2005)

Based on our results, the alterations of epithelial growth factor receptor and p53 expression show ulcerative colitis specificity, whereas the rate of epithelial apoptosis and proliferation are determined by the histologic activity of the inflammation. The increased epithelial growth factor receptor expression by the lamina propria's mononuclear cells in inflammation may suggest its role as an autoantigen.
Enhanced<i>in vitro</i>production of amyloid-like fibrils from mutant (S20G) islet amyloid polypeptide (2001)

The amino acid substitution (S20G) is situated close to the region of the IAPP molecule implicated in the IAPP fibrillogenesis. The significantly increased formation of amyloid-like fibrils by IAPPS20G is highly interesting and may be associated with an increased islet amyloid formation in vivo and of fundamental importance in the pathogenesis of this specific form of diabetes.
Effect of structural anisotropy on anchor loss mismatch and predicted case drift in future micro-Hemispherical Resonator Gyros (2014)

The effect of structural anisotropy leading to anchor loss mismatch in micro-Hemispherical Resonator Gyros (micro-HRGs) is investigated by developing an anchor loss model based on finite element analysis. Worst-case lower bound estimates for the anchor loss component of the quality factor (Q) are found based on the computed frequency difference between a clamped support and a free support interface. The Young's modulus of the finite element model is varied in a 4 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> -harmonic pattern in the circumferential direction of the micro-HRG, resulting in splitting of the Q and resonance frequency of the otherwise degenerate gyro wineglass mode pair, allowing prediction of the case drift performance.
Developmental changes in choline- and ethanolamine-containing compounds measured with proton-decoupled31P MRS in in vivo human brain (1999)

Cerebral phosphorylated metabolites, possibly involved in membrane and myelin sheath metabolism, were measured and quantified using proton-decoupled (31)P ({(1)H}-(31)P) MRS in 32 children and 28 adults. Age-dependent changes were determined for phosphorylethanolamine (PE), phosphorylcholine (PC), glycerophosphorylethanolamine (GPE), glycerophosphorylcholine (GPC), and phosphocreatine (PCr) concentrations. In the neonate, PE dominates the spectrum and decreases with age along with PC, whereas GPE, GPC, and PCr increase in concentration with postnatal age. PE (1.23 +/- 0.13 mM) and GPE (0.57 +/- 0.08 mM) co-resonate with choline in (1)H MRS. Together with PC (0.57 +/- 0.12 mM) and GPC (0. 94 +/- 0.13 mM) these four metabolites accounted for all of the visible (1)H MRS choline in normal adult brain. Children with diseases that affect myelination were found to have abnormal ¿(1)H¿-(31)P MRS. The new quantitative assay may provide novel insights in determining and monitoring normal and abnormal brain maturation noninvasively. Magn Reson Med 42:643-654, 1999.