gebhart/patrepeval huggingface dataset:
Robust Flutter Margin Analysis that Incorporates Flight Data (1998)

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 NOMENCLATURE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 CHAPTER 1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 CHAPTER 2 ROBUST STABILITY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.1 Signals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.2 Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2.3 Small Gain Theorem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....
Complexity of Blocking Bivalent Protein–Protein Interactions: Development of a Highly Potent Inhibitor of the Menin–Mixed-Lineage Leukemia Interaction (2018)

The protein-protein interaction between menin and mixed-lineage leukemia 1 (MLL1) plays an important role in development of acute leukemia with translocations of the MLL1 gene and in solid tumors. Here, we report the development of a new generation of menin-MLL1 inhibitors identified by structure-based optimization of the thienopyrimidine class of compounds. This work resulted in compound 28 (MI-1481), which showed very potent inhibition of the menin-MLL1 interaction (IC<sub>50</sub> = 3.6 nM), representing the most potent reversible menin-MLL1 inhibitor reported to date. The crystal structure of the menin-28 complex revealed a hydrogen bond with Glu366 and hydrophobic interactions, which contributed to strong inhibitory activity of 28. Compound 28 also demonstrates pronounced activity in MLL leukemia cells and in vivo in MLL leukemia models. Thus, 28 is a valuable menin-MLL1 inhibitor that can be used for potential therapeutic applications and in further studies regarding the role of menin in cancer.
Local Computation of PageRank Contributions (2008)

Motivated by the problem of detecting link-spam, we consider the following graph-theoretic primitive: Given a webgraph _G_, a vertex _υ_ in _G_, and a parameter δ ∈ (0, 1), compute the set of all vertices that contribute to _υ_ at least a δ-fraction of _υ_'s PageRank. We call this set the δ-contributing set of _υ_. To this end, we define the contribution vector of _υ_ to be the vector whose entries measure the contributions of every vertex to the PageRank of _υ_. A local algorithm is one that produces a solution by adaptively examining only a small portion of the input graph near a specified vertex. We give an efficient local algorithm that computes an ε-approximation of the contribution vector for a given vertex by adaptively examining _O_(1/ε) vertices. Using this algorithm, we give a local approximation algorithm for the primitive defined above. Specifically, we give an algorithm that returns a set containing the δ-contributing set of _υ_ and at most _O_(1/δ) vertices from the δ/2-contributing set of _υ_, and that does so by examining at most _O_(1/δ) vertices. We also give a local algorithm for solving the following problem: If there exist _k_ vertices that contribute a _ρ_-fraction to the PageRank of _υ_, find a set of _k_ vertices that contribute at least a (_ρ_−ε)-fraction to the PageRank of _υ_. In this case, we prove that our algorithm examines at most _O_(_k_/ε) vertices.
Synthesis and Antibacterial Activity of Mefloquine-Based Analogs Against Sensitive and Resistant Mycobacterium tuberculosis Strains (2019)

All synthesized compounds, with the exception of 5, exhibited activity against the Mtb. Compound 3c was the most potent against resistant and sensitive Mtb in this series, with MIC value of 37.2 µM. All compounds showed low cytotoxicity. These findings could be considered a good model to develop possible lead compounds in the fight against TB based on Mefloquine nucleus.
Ultrasonic Array Transducer Using Interdigital Electrode (1984)

A `planar array transducer' with interdigital electrodes is proposed. This paper describes the structure of the transducer and experimentally investigates its behavior and realization feasibility. A transducer directivity using PbTiO 3 ceramics with a large electromechanical anisotropy shows the independent behavior of an array element that consists of a few electrode finger pairs. It was found that the array transducer could be realized without cutting by using the planar structure and also that the optimum pattern ratio R (the ratio of electrode finger width to period) is about 0.5.
Rights protection for categorical data (2005)

A novel method of rights protection for categorical data through watermarking is introduced in this paper. New watermark embedding channels are discovered and associated novel watermark encoding algorithms are proposed. While preserving data quality requirements, the introduced solution is designed to survive important attacks, such as subset selection and random alterations. Mark detection is fully "blind" in that it doesn't require the original data, an important characteristic, especially in the case of massive data. Various improvements and alternative encoding methods are proposed and validation experiments on real-life data are performed. Important theoretical bounds including mark vulnerability are analyzed. The method is proved (experimentally and by analysis) to be extremely resilient to both alteration and data loss attacks, for example, tolerating up to 80 percent data loss with a watermark alteration of only 25 percent.
Design of an imaging bolometer system for the large helical device (1997)

We describe a radical design for a bolometer system employing infrared (IR) imaging of a segmented-matrix absorber in a cooled-pinhole camera geometry, which we will prototype and demonstrate on the large helical device (LHD).1 LHD will be operational in early 1998, with an l=2 superconducting winding, a major radius of 3.9 m, a minor radius of 0.5–0.65 m, and input powers ranging from 3 MW (steady state) to 30 MW (pulsed). The bolometer design parameters are determined by modeling the temperature of the foils making up the detection matrix using a two-dimensional time-dependent solution of the heat conduction equation. This design will give a steady-state bolometry capability, with modest (60 Hz) time resolution, while simultaneously providing hundreds of channels of spatial information. No wiring harnesses will be required, as the temperature-rise data is measured via a 12-bit, ±0.025 °C resolution, 3–5 μm band, 256×256 pixel IR camera. The spatial data will be used to tomographically invert the profile of the highly shaped stellarator main plasma and divertor radiation, in conjunction with more conventional fanned arrays of traditional bolometers.
Transcutaneous Immunization (2003)

Transcutaneous immunization (TCI), the introduction of antigens using a topical application to intact skin, is a new technology that has both practical and immunological merits. Practically speaking, a needle-free method of vaccine delivery will decrease the risk of needle-borne diseases, reduce the complications related to physical skin penetration, improve access to vaccination by eliminating the need for trained personnel and sterile equipment, and provide a simple means for multivalent or multiple boosting immunization. The immunological implications of TCI are profound as this technique appears to target highly accessible antigen presenting cells (APC) in the skin that can be exploited for a variety of immune outcomes. It has been our experience that TCI can be reliably and reproducibly conducted with a variety of antigens to induce potent and functional immune responses. Thus, this new method may significantly impact both the delivery of vaccines and open new possibilities for manipulation of the immune response.
Experiments on the Use of Signal Visualization Technique for In-Service Stall Detection in Industrial Fans (2013)

The paper describes a stalldetection criterion based on the use of symmetrised dot pattern (SDP) visual waveform analysis and the stallwarning methodology based on a recently developed analysis. The experimental study explores the capability of the SDP technique to detect the stall incipience and evolution in the presence of low signal-to-noise ratios, that is, a noisy working environment. Moreover, the investigation presents a systematic analysis on the probe position’s influence with respect to the fan section. As such, the SDP technique in combination with an acoustic measurement is able to create a visual pattern that one can use to detect stall from potentially any location around the fan/duct system.
Monte-Carlo Ray-Tracing for Realistic Interactive Ultrasound Simulation (2016)

Ray-based simulations have been shown to generate impressively realistic ultrasound images in interactive frame rates. Recent efforts used GPU-based surface ray-tracing to simulate complex ultrasound interactions such as multiple reflections and refractions. These methods are restricted to perfectly specular reflections (i.e., following only a single reflective/refractive ray), whereas real tissue exhibits roughness of varying degree at tissue interfaces, causing partly diffuse reflections and refractions. Such surface interactions are significantly more complex and can in general not be handled by such deterministic ray-tracing approaches. However, they can be efficiently computed by Monte-Carlo sampling techniques, where many ray paths are generated with respect to a probability distribution. In this paper we introduce Monte-Carlo ray-tracing for ultrasound. This enables the realistic simulation of ultrasound interactions such as soft shadows and fuzzy reflections. We discuss how to properly weight the contribution of each ray path in order to simulate the behavior of a beamformed ultrasound signal. Tracing many individual rays per transducer element is easily parallelizable on modern GPUs, as opposed to previous approaches based on recursive binary ray-tracing.
Optimal integrated schedule of entire process of dual-blade multi-cluster tools from start-up to close-down (2019)

Multi-cluster tools are widely used in majority of wafer fabrication processes in semiconductor industry. Smaller lot production, thinner circuit width in wafers, larger wafer size, and maintenance have resulted in a large quantity of their start-up and close-down transient periods. Yet, most of existing efforts have been concentrated on scheduling their steady states. Different from such efforts, this work schedules their transient and steady-state periods subject to wafer residency constraints. It gives the schedulability conditions for the steady-state scheduling of dual-blade robotic multi-cluster tools and a corresponding algorithm for finding an optimal schedule. Based on the robot synchronization conditions, a linear program is proposed to figure out an optimal schedule for a start-up period, which ensures a tool to enter the desired optimal steady state. Another linear program is proposed to find an optimal schedule for a closedown period that evolves from the steady state period. Finally, industrial cases are presented to illustrate how the provided method outperforms the existing approach in terms of system throughput improvement.
Continuous respiratory rate monitoring during an acute hypoxic challenge using a depth sensing camera (2019)

Respiratory rate is a well-known to be a clinically important parameter with numerous clinical uses including the assessment of disease state and the prediction of deterioration. It is frequently monitored using simple spot checks where reporting is intermittent and often prone to error. We report here on an algorithm to determine respiratory rate continuously and robustly using a non-contact method based on depth sensing camera technology. The respiratory rate of 14 healthy volunteers was studied during an acute hypoxic challenge where blood oxygen saturation was reduced in steps to a target 70% oxygen saturation and which elicited a wide range of respiratory rates. Depth sensing data streams were acquired and processed to generate a respiratory rate (RR<sub>depth</sub>). This was compared to a reference respiratory rate determined from a capnograph (RR<sub>cap</sub>). The bias and root mean squared difference (RMSD) accuracy between RR<sub>depth</sub> and the reference RR<sub>cap</sub> was found to be 0.04 bpm and 0.66 bpm respectively. The least squares fit regression equation was determined to be: RR<sub>depth</sub> = 0.99 × RR<sub>cap</sub> + 0.13 and the resulting Pearson correlation coefficient, R, was 0.99 (p < 0.001). These results were achieved with a 100% reporting uptime. In conclusion, excellent agreement was found between RR<sub>depth</sub> and RR<sub>cap</sub>. Further work should include a larger cohort combined with a protocol to further test algorithmic performance in the face of motion and interference typical of that experienced in the clinical setting.
Mitigation of position dependence in x-rays absorbers for Thermal Kinetic Inductance Detectors (2014)

The currently available microcalorimeter technologies are all affected by the difficulty of multiplexing large numbers of pixels (<1000). Microwave kinetic inductance detectors, on the other hand, are intrinsically highly multiplexible. We have recently shown that it is possible to use a superconducting resonator as a thermometer for a microcalorimeter (TKID). The moderate sensitivity of the resonator of a TKID requires a low heat capacity absorber (e.g. like Tantalum, Tin) in order to achieve sufficient signal to noise and absorption efficiency. These materials are often characterized by poor thermalization properties, which give rise to a position dependent response. In this work we introduce a new design solution based on a bilayer of Tantalum and Gold grown on a perforated SiN island that provides better thermalization properties and reduces the position dependence, while maintaining a small total heat capacity.
Antimicrobial durability and rare ultrastructural colonization of indwelling central catheters coated with minocycline and rifampin (1998)

Coating catheters with minocycline and rifampin inhibits ultrastructural colonization of indwelling catheters and maintains effective antimicrobial activity for at least 2 wks.
Nitrogen-14 NMR Spectroscopy Using Residual Dipolar Splittings in Solids (2006)

It is shown that nuclear magnetic resonance (NMR) spectra of nitrogen-14 (spin I = 1) can be obtained by indirect detection in powders spinning at the magic angle (MAS). The method relies on the transfer of coherence from a neighboring nucleus with S = 1/2, such as carbon-13, to single- or double-quantum transitions of nitrogen-14 nuclei. The transfer of coherence occurs through second-order quadrupole-dipole cross terms, also known as residual dipolar splittings. The two-dimensional NMR spectra reveal powder patterns determined by the second-order quadrupolar interactions of nitrogen-14. Analysis of the spectra yields the quadrupolar coupling constant, CQ, and asymmetry parameter, etaQ, of nitrogen-14. These parameters can be related to the structure of nitrogen-containing solids.
A scalable hash ripple join algorithm (2002)

Recently, Haas and Hellerstein proposed the hash ripple join algorithm in the context of online aggregation. Although the algorithm rapidly gives a good estimate for many join-aggregate problem instances, the convergence can be slow if the number of tuples that satisfy the join predicate is small or if there are many groups in the output. Furthermore, if memory overflows (for example, because the user allows the algorithm to run to completion for an exact answer), the algorithm degenerates to block ripple join and performance suffers. In this paper, we build on the work of Haas and Hellerstein and propose a new algorithm that (a) combines parallelism with sampling to speed convergence, and (b) maintains good performance in the presence of memory overflow. Results from a prototype implementation in a parallel DBMS show that its rate of convergence scales with the number of processors, and that when allowed to run to completion, even in the presence of memory overflow, it is competitive with the traditional parallel hybrid hash join algorithm.
Recent Mechanistic Understanding of Fischer-Tropsch Synthesis on Fe-Carbide (2023)

With an increase in energy consumption globally, Fischer-Tropsch (FT) synthesis is a good alternative for producing fuels and chemicals from coal, natural gas or biomass. Among them, coal to liquids has been put into production in countries that have large coal reserves. In this process, Fe-based catalysts are commonly used due to their earth abundance, comparatively wide operation range and ready availability to handle low H2/CO ratio from coal. Despite their extensive applications, the kinetic and mechanistic understandings of Fe carburization and FT reaction on Fe-carbides are relatively limited due to the complexity of phase composition of the applied catalysts. This review summarizes the current state of knowledge of FT synthesis on Fe-carbide with an emphasis on underlying mechanism. Specifically, the employment of model catalyst, such as Raney-Fe, could provide a convenient way to furnish kinetic information regarding Fe carburization and subsequent FT reaction. A major challenge for further understanding catalytic reactions occurring at the Fe-carbide surface is correlating FT activity and selectivity to specific active site. To address this issue, the advancements of both DFT calculations and surface science techniques are highly demanded.
LLC resonant converter with shared power switches and dual coupled resonant tanks to achieve automatic current sharing (2017)

In this paper, a novel LLC resonant converter with parallel input and parallel output circuit topology is proposed to achieve the good performance of reduced switch count and medium power compared with conventional parallel half-bridge resonant converter. The proposed LLC resonant converter has two resonant circuits, two resonant circuits use the same power switches to transmit power so that the switch counts are reduced compared with the conventional two-phase LLC resonant converter. The resonant inductors of each resonant circuit are shared to achieve automatic resonant current sharing performance and then to balance the current stress of passive elements, such as transformer, secondary-side rectifier even sough there are components tolerance of each resonant circuit. Mathematical model based on Fundamental Harmonic analysis (FHA) is built. The FHA analysis shows that there is same ZVS and ZCS performance with conventional LLC Converter. Two-phase conventional LLC converter and proposed LLC converter can be analyzed. A 600W experiment prototype is built to verify the feasibility and excellent current sharing performance has been demonstrated. The experimental results are shown that the current sharing error of two tanks is smaller 5% at worst case. The resonant current error of each tank is only 2.5% at total rated load power with the proposed LLC converter.
The Liberty Myoarraytm: A Diagnostic Tool To Test And Train Amputees To Use Myoelectric Prostheses (1993)

When fitting a patient with a myoelectric prosthetic device, a prosthetist or therapist tests the patient to determine the best location on the muscle to place the electrodes Generally, the optimal location is the one where the myoelectic signal is strongest Typically, a prosthetist attempts to determine this location through trial-and-error,. This is time-consuming and the resulting signals are often inconsistent because each contraction is different.\nOthers have proposed or utilized multiple electrodes for monitoring muscle activity and one research study resulted in a system to facilitate muscle-site identification. These systems however, depend on repetitive or sustained muscle contractions which may introduce another variable, misleading the prosthetist In addition, these approaches take significantly longer to perform and may tire the patient.\nThe Liberty MyoArray* has been developed to provide an easy-to-use, portable diagnostic system for quickly measuring myoelectric signals from several locations at once, over a wide muscle area It increases the likelihood of proper patient fit and control of the prosthesis. For the experienced prosthetists, it speeds the process and it allows the inexperienced prosthetists to succeed with myoelectric technology It eliminates the possibility of error caused by variation in muscle flexions and facilitates training by providing feedback while the amputee is performing controlled muscle contractions.
Nucleic Acid-based Technologies in Therapy of Malignant Gliomas (2011)

Malignant gliomas are the deadliest brain tumors, which are characterized by highly invasive growth, a rampant genetic instability and intense resistance to apoptosis. Such an aggressive behavior of malignant gliomas is reflected in the resistance to chemo- and radiotherapy and weak prognosis in spite of cytoreduction through surgery. Brain tumors preferentially express a number of specific protein and RNA markers, that may be exploited as potential therapeutic targets in design of the new treatment modalities based on nucleic acids. For almost three decades, a possibility to apply DNA and RNA molecules as anticancer therapeutics have been studied. A variety of antisense oligonucleotides, ribozymes, DNAzymes, and aptamers can be designed to trigger the sequence-specific inhibition of particular mRNA of interest. RNA interference (RNAi) is the latest and the most promising technique in the long line of nucleic acid-based therapeutic technologies. Recently, we designed and implemented the experimental therapy of patients suffering from malignant brain tumors based on application of double-stranded RNA (dsRNA) specific for tenascin-C (TN-C) mRNA. That therapeutic agent, called ATN-RNA, induces RNAi pathway to inhibit the synthesis of TN-C, the extracellular matrix protein which is highly overexpressed in brain tumor tissue. In the chapter specific problems of application of nucleic acid-based technologies in glioma tumors treatment will be discussed.
Dispersion design in gradient index elements using ternary blends (2016)

We show that a gradient-index element designed from a blend of three materials allows a designer to specify independently the element's refractive index and its change in refractive index with respect to wavelength. We show further the effectiveness of this approach by comparing modeled chromatic performance of deflectors consisting of a single material, a binary blend of materials, and a ternary blend.
Production of Monoclonal Antibodies to Pathologic β-sheet Oligomeric Conformers in Neurodegenerative Diseases (2017)

We describe a novel approach to produce conformational monoclonal antibodies selected to specifically react with the β-sheet secondary structure of pathological oligomeric conformers, characteristic of many neurodegenerative diseases. Contrary to past and current efforts, we utilize a mammalian non-self-antigen as an immunogen. The small, non-self peptide selected was covalently polymerized with glutaraldehyde until it reached a high β-sheet secondary structure content, and species between 10-100kDa that are immunogenic, stable and soluble (p13Bri). Inoculation of p13Bri in mice elicited antibodies to the peptide and the β-sheet secondary structure conformation. Hybridomas were produced and clones selected for their reactivity with at least two different oligomeric conformers from Alzheimer's, Parkinson and/or Prion diseases. The resulting conformational monoclonals are able to detect pathological oligomeric forms in different human neurodegenerative diseases by ELISA, immunohistochemistry and immunoblots. This technological approach may be useful to develop tools for detection, monitoring and treatment of multiple misfolding disorders.