gebhart/patrepeval huggingface dataset:
Characteristics of Annealed Proton Exchanged Waveguides for Quasi-Phase-Matched Frequency Conversion in Periodically-Poled LiNbO3 Waveguides (1991)

Nonlinear frequency conversion in waveguides has been investigated since the first days of integrated optics, but practical applications were hampered by a lack of suitable pump lasers and the often inconvenient phase-matching characteristics of the available waveguides. Recent developments in high power (>100 mW) single-mode diode lasers and quasi-phase-matching techniques have led to renewed interest in waveguide frequency conversion. Periodic modulation of the optical properties of a nonlinear medium, quasi-phase-matching, is an attractive technique as it decouples phase-matching from birefringence and thus allows any interaction within the transparency range of the medium using any component of the nonlinear susceptibility tensor. The most efficient form of quasi-phase-matching involves periodic reversal of the sign of the nonlinear susceptibility (χ (2) ) of the medium, with a period equal to an odd multiple of the coherence length of the interaction. In ferroelectrics, such a periodic sign reversal in χ (2) can be accomplished by periodic reversals in the orientation of the spontaneous polarization. Periodic incorporation of dopants has been found to induce domain reversal in several ferroelectrics, e.g. Ti or Li in LiNbO 3 , H in LiTaO 3 , and Rb and Ba in KTP, leading to rapid progress in device demonstrations in these material systems. [1–5] Several milliwatts of blue light generated by quasi-phase-matched (QPM) frequency doubling have been demonstrated in LiNbO 3 [3],[6], Ktp [4], and LiTaO 3 waveguides [5], as has QPM difference frequency generation of 2.1 μm radiation in LiNbO 3 waveguides. [7]
Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells (2012)

HDL particles may enter atherosclerotic lesions having an acidic intimal fluid. Therefore, we investigated whether acidic pH would affect their structural and functional properties. For this purpose, HDL(2) and HDL(3) subfractions were incubated for various periods of time at different pH values ranging from 5.5 to 7.5, after which their protein and lipid compositions, size, structure, and cholesterol efflux capacity were analyzed. Incubation of either subfraction at acidic pH induced unfolding of apolipoproteins, which was followed by release of lipid-poor apoA-I and ensuing fusion of the HDL particles. The acidic pH-modified HDL particles exhibited an enhanced ability to promote cholesterol efflux from cholesterol-laden primary human macrophages. Importantly, treatment of the acidic pH-modified HDL with the mast cell-derived protease chymase completely depleted the newly generated lipid-poor apoA-I, and prevented the acidic pH-dependent increase in cholesterol efflux. The above-found pH-dependent structural and functional changes were stronger in HDL(3) than in HDL(2). Spontaneous acidic pH-induced remodeling of mature spherical HDL particles increases HDL-induced cholesterol efflux from macrophage foam cells, and therefore may have atheroprotective effects.
Substance P and the Inflammatory and Immune Response (1991)

These findings suggest that SP may have proinflammatory actions in both the peripheral tissue and the central nervous system after tissue injury. Although the possibility that the same neuropeptide could have actions in both the brain and the peripheral tissues is certainly not without precedent, there is a key difference in the source of the ligand in these tissues. Unlike peripheral tissues such as the gastrointestinal tract or skin, where there is a dense innervation by SP-containing dorsal root ganglion neurons, the brain lacks such a sensory innervation. This important difference raises the question as to the possible origin of the SP that could occupy the SP receptors expressed by the CNS glia after neuronal injury. Whereas the answer to this question is currently unknown, an important clue may be the findings that circulating leukocytes have been reported to synthesize neuropeptides such as ACTH, opiates, and SP. To begin to fully understand the role that SP may play in coordinating the inflammatory and immune response to tissue injury, we must first understand where SP fits into the cascade of events that occur after tissue injury, what events lead to nociceptor sensitization (which may lead to an increase in SP release), and what regulates SP receptor expression (which may be involved in the direction of leukocytes to the site of injury, plasma extravasation, or the proliferation/hypertrophy of reactive astrocytes). Although this may seem like a daunting task, several recent advances including the cloning of the three mammalian tachykinin receptors and the introduction of highly potent and specific SP receptor antagonists should make this a highly fruitful field of investigation.
Molecular mechanisms of dissociative glucocorticoid activity (2000)

This is the first system that allows efficient analysis of glucocorticoid-dependent transactivation and transrepression in normal human lymphocytes. Compared to conventional glucocorticoids, MPA can be referred to as a dissociative glucocorticoid, its transrepression/transactivation ratio being 6.6 (transrepression 1.91/transactivation 0.29), with dexamethasone being the standard (transrepression 1/transactivation 1). We conclude that MPA is a highly promising substance for the treatment of autoimmune/inflammatory diseases.
PI3K/PTEN/Akt/mTOR pathway aberrations and co-incidence of hormone receptors and HER2 in 19,784 diverse solid tumors. (2015)

11042 Background: Molecular aberrations in the phosphatidylinositol 3-kinase (PI3K) pathway have been documented across cancers, especially PIK3CAmutations and mutation or loss of PTEN. These alterations may be relevant to therapies targeting the PI3K/PTEN/Akt/mTOR signaling pathway. Methods: Molecular profiling was performed on 19,784 tumors ( > 40 cancer types) at a CLIA-certified laboratory. Tests included next generation sequencing (NGS), protein expression (immunohistochemistry), and gene amplification (FISH or CISH). Results: Frequency and type of PIK3CA, AKT1 and PTEN mutations were collated across cancers. Aggregate gene mutation rates (47 genes), protein expression rates (18 proteins), and copy number (5 biomarkers) were measured. Comparison of frequencies and correlations across cancers identified lineage-specific differences, and co-incidences of associated biomarkers, which will be described. Of note, endometrial, breast, cervical, anal squamous cell, and bladder cancers had the highest PIK3CA mutation rate (37%, n = 1600; 31%, n = 2282; 29%, n = 284; 28%, n = 67, 22%, n = 303, respectively). Patterns in AKT1 and PTEN mutation rates differed by cancer, as did PTEN loss - hepatocellular, 57%, prostate, 52%, and endometrial 50% loss. Co-mutation of PTEN and PIK3CA occurred in 1.5% of breast, 0% of prostate, and 12% of endometrial cancers. Of interest, PIK3CA mutations and PTEN loss co-occurred frequently, e.g. 31% of PIK3CAmutated patients also have a PTEN loss. PIK3CA mutations across cancers were distributed 43% in exon 9, 33% in exon 20, and 24% in other exons. Distribution of PIK3CA mutations by cancer type varied and occurred more frequently in the absence of HER2 protein expression or copy number increase (p= 0.0001) and more frequently in the presence of hormone receptor overexpression (androgen receptor (AR), progesterone receptor (PR), and estrogen receptor (ER)) (p= 0.0335). PTEN loss was seen in 27% of patients with and 30% without HER2 overexpression or amplification (p= 0.004). Conclusions: Patterns of biomarker co-alterations across cancers may provide new insights relevant to targeted therapy and may be crucial to optimizing combination treatments.
Engineered growth factors and cutaneous wound healing: Success and possible questions in the past 10 years (2005)

In the past 10 years, many engineered growth factors, including recombinant human epidermal growth factor, basic fibroblast growth factor, and platelet-derived growth factor, have been produced and used in the clinic. After screening the results from different centers, some results are found to be encouraging, while others are discouraging. Although the interpretation of these results may depend on your perspective, it may also depend on different criteria, different wounds, and even different aims. In this article, successful experiences and failures concerning the use of growth factors and cutaneous wound healing are summarized. Based on this information and our clinical experience, we address people's concerns such as whether growth factors have altered clinical practice thus far and whether growth factor treatments have solved all problems involved in wound healing. Is there a need for exogenous application of growth factors in acute or chronic wounds, and if so, is it safe to use growth factors to promote wound healing? Last, can we achieve perfect wound healing in those wounds treated with growth factors?
Synthesis and Self-assembly of Amphiphilic Semifluorinated Calix[4]arenes (2004)

A new amphiphilic molecule based on the calix[4]arene scaffold was synthesized by. appending perfluoroalkyl chains on the upper rim and polar groups on the lower rim of the macrocycle. This molecule self-assembles in water and methanol due to formation of a super-hydrophobic fluorous phase. Bilayer assemblies were observed using dynamic light scattering (DLS) and transmission electron microscopy (TEM). The aggregate architecture is strongly influenced by the solvent. Fibers formed by stacked disks were observed in methanol, whereas spherical aggregates were favored in an aqueous environment.
Left Ventricular Transmural Gradient in Mitochondrial Respiration Is Associated with Increased Sub-Endocardium Nitric Oxide and Reactive Oxygen Species Productions (2016)

LV mitochondrial respiration transmural gradient is likely related to NO and possibly ROS increased production in the sub-endocardium.
A personal knowledge base integrating user data and activity timeline (2017)

Aujourd'hui, la plupart des internautes ont leurs données dispersées dans plusieurs appareils, applications et services. La gestion et le contrôle de ses données sont de plus en plus difficiles. Dans cette thèse, nous adoptons le point de vue selon lequel l'utilisateur devrait se voir donner les moyens de récupérer et d'intégrer ses données, sous son contrôle total. À ce titre, nous avons conçu un système logiciel qui intègre et enrichit les données d'un utilisateur à partir de plusieurs sources hétérogènes de données personnelles dans une base de connaissances RDF. Le logiciel est libre, et son architecture innovante facilite l'intégration de nouvelles sources de données et le développement de nouveaux modules pour inférer de nouvelles connaissances. Nous montrons tout d'abord comment l'activité de l'utilisateur peut être déduite des données des capteurs de son téléphone intelligent. Nous présentons un algorithme pour retrouver les points de séjour d'un utilisateur à partir de son historique de localisation. À l'aide de ces données et de données provenant d'autres capteurs de son téléphone, d'informations géographiques provenant d'OpenStreetMap, et des horaires de transports en commun, nous présentons un algorithme de reconnaissance du mode de transport capable de retrouver les différents modes et lignes empruntés par un utilisateur lors de ses déplacements. L'algorithme reconnaît l'itinéraire pris par l'utilisateur en retrouvant la séquence la plus probable dans un champ aléatoire conditionnel dont les probabilités se basent sur la sortie d'un réseau de neurones artificiels. Nous montrons également comment le système peut intégrer les données du courrier électronique, des calendriers, des carnets d'adresses, des réseaux sociaux et de l'historique de localisation de l'utilisateur dans un ensemble cohérent. Pour ce faire, le système utilise un algorithme de résolution d'entité pour retrouver l'ensemble des différents comptes utilisés par chaque contact de l'utilisateur, et effectue un alignement spatio-temporel pour relier chaque point de séjour à l'événement auquel il correspond dans le calendrier de l'utilisateur. Enfin, nous montrons qu'un tel système peut également être employé pour faire de la synchronisation multi-système/multi-appareil et pour pousser de nouvelles connaissances vers les sources. Les résultats d'expériences approfondies sont présentés.
Treponema lecithinolyticum sp. nov., a small saccharolytic spirochaete with phospholipase A and C activities associated with periodontal diseases (1999)

Strong phospholipase A (PLA) and phospholipase C (PLC) activities as potential virulence factors are the outstanding characteristics of eight strains of small oral spirochaetes isolated from deep periodontal lesions. By qualitative dot-blot DNA-DNA hybridization and 16S rDNA sequence comparison, these spirochaetes form a distinct phylogenetic group, with Treponema maltophilum as its closest cultivable relative. Growth of these treponemes, cells of which contain two endoflagella, one at each pole, was autoinhibited by the PLA-mediated production of lysolecithin unless medium OMIZ-Pat was prepared without lecithin. N-Acetylglucosamine was essential and D-ribose was stimulatory for growth. All isolates were growth-inhibited when 1% foetal calf serum was added to the medium. Growth on agar plates supplemented with human erythrocytes produced haemolysis. In addition to PLA and PLC, the new isolates displayed strong activities of alkaline and acid phosphatases, beta-galactosidase, beta-glucuronidase, N-acetyl-beta-glucosaminidase and sialidase, intermediate activities of C4- and C8-esterases, naphthol phosphohydrolase and alpha-fucosidase and a distinctive 30 kDa antigen detectable on Western blots. This phenotypically and genotypically homogeneous group is proposed as a novel species, Treponema lecithinolyticum sp. nov., with isolate OMZ 684T designated as the type strain. A molecular epidemiological analysis using a T. lecithinolyticum-specific probe showed this organism to be associated with affected sites when compared with unaffected sites of periodontitis patients. This association was more pronounced in patients with rapidly progressive periodontitis than in those with adult periodontitis.
Investigation of Pulse Detonation Engines; Theory, Design and Analysis (2013)

This Thesis- ERAU Login Required is brought to you for free and open access by ERAU Scholarly Commons. It has been accepted for inclusion in Dissertations and Theses by an authorized administrator of ERAU Scholarly Commons. For more information, please contact commons@erau.edu.
Attractiveness of a novel omnivore bait, PIGOUT®, to feral pigs (Sus scrofa) and assessment of risks of bait uptake by non-target species (2006)

Following a bait-preference pilot study on captive feral pigs, a series of field studies assessed the attractiveness and target-specificity of a prototype manufactured feral pig bait (PIGOUT®). Two promising test baits and fresh meat reference baits were biomarked with iophenoxic acid and aerially distributed in 100-km2 blocks of land infested with feral pigs in western Queensland to assess field uptake and target-specificity without prefeeding. Uptake was assessed by measuring blood iodine levels in aerially shot feral pigs. In all, 80% of feral pigs sampled in a non-toxic PIGOUT®-baited area had significantly elevated blood iodine, compared with 52% of sampled feral pigs in a meat-baited area (although slightly different baiting strategies were employed). No age or sex bias was evident in PIGOUT®-consuming feral pigs. No monitored manufactured baits were consumed by non-target species in 500 bait-nights. Attractiveness and target-specificity trials of ground-laid, unfenced PIGOUT® baits compared with reference baits were subsequently undertaken in several regions of eastern Australia. Results showed that PIGOUT® was consumed readily by feral pigs at all sites, and that it offered significant improvement in target specificity when compared with unfenced wheat or meat baits. However, the baits were consumed by small numbers of macropods, birds and possums. Available evidence indicates that the target-specificity of PIGOUT® bait is highest in the rangelands, reducing slightly in temperate areas and subalpine forests, where abundance of small animals is higher.
<i>TraClass</i> (2008)

Trajectory classification, i.e. , model construction for predicting the class labels of moving objects based on their trajectories and other features, has many important, real-world applications. A number of methods have been reported in the literature, but due to using the shapes of whole trajectories for classification, they have limited classification capability when discriminative features appear at parts of trajectories or are not relevant to the shapes of trajectories. These situations are often observed in long trajectories spreading over large geographic areas. Since an essential task for effective classification is generating discriminative features, a feature generation framework TraClass for trajectory data is proposed in this paper, which generates a hierarchy of features by partitioning trajectories and exploring two types of clustering: (1) region-based and (2) trajectory-based. The former captures the higher-level region-based features without using movement patterns, whereas the latter captures the lower-level trajectory-based features using movement patterns. The proposed framework overcomes the limitations of the previous studies because trajectory partitioning makes discriminative parts of trajectories identifiable, and the two types of clustering collaborate to find features of both regions and sub-trajectories. Experimental results demonstrate that TraClass generates high-quality features and achieves high classification accuracy from real trajectory data.
Nondependence of diffusion-controlled peak dispersion on diffusion coefficient and ionic mobility in capillary zone electrophoresis without electroosmotic flow (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNondependence of diffusion-controlled peak dispersion on diffusion coefficient and ionic mobility in capillary zone electrophoresis without electroosmotic flowErnst. Kenndler and Christine. SchwerCite this: Anal. Chem. 1991, 63, 21, 2499–2502Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/ac00021a019https://doi.org/10.1021/ac00021a019research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
30.2: HDMI: High‐Definition Multimedia Interface (2003)

Abstract The year 2002 heralded the transition of television to a digital interface, with widespread DVI/HDCP adoption in digital televisions and high‐definition set‐top boxes. The High‐Definition Multimedia Interface (HDMI) will supplant DVI as the digital television interface of choice over the next few years. HDMI is fully backward compatible with DVI and incorporates digital audio, standard television video formats, link intelligence, and a more robust, consumer friendly connector. This paper reviews the technology specified by HDMI.
Synthesis of polynitroadamantanes. Oxidations of oximinoadamantanes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of polynitroadamantanes. Oxidations of oximinoadamantanesT. G. Archibald and K. BaumCite this: J. Org. Chem. 1988, 53, 20, 4645–4649Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/jo00255a001https://doi.org/10.1021/jo00255a001research-articleACS PublicationsRequest reuse permissionsArticle Views614Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer (2012)

Mutations in TP53 lead to a defective G1 checkpoint and the dependence on checkpoint kinase 1 (Chk1) for G2 or S phase arrest in response to DNA damage. In preclinical studies, Chk1 inhibition resulted in enhanced cytotoxicity of several chemotherapeutic agents. The high frequency of TP53 mutations in triple negative breast cancer (TNBC: negative for estrogen receptor, progesterone receptor, and HER2) make Chk1 an attractive therapeutic target. UCN-01, a non-selective Chk1 inhibitor, combined with irinotecan demonstrated activity in advanced TNBC in our Phase I study. The goal of this trial was to further evaluate this treatment in women with TNBC. Patients with metastatic TNBC previously treated with anthracyclines and taxanes received irinotecan (100-125 mg/m(2) IV days 1, 8, 15, 22) and UCN-01 (70 mg/m(2) IV day 2, 35 mg/m(2) day 23 and subsequent doses) every 42-day cycle. Peripheral blood mononuclear cells (PBMC) and tumor specimens were collected. Twenty five patients were enrolled. The overall response (complete response (CR) + partial response (PR)) rate was 4 %. The clinical benefit rate (CR + PR + stable disease ≥6 months) was 12 %. Since UCN-01 inhibits PDK1, phosphorylated ribosomal protein S6 (pS6) in PBMC was assessed. Although reduced 24 h post UCN-01, pS6 levels rose to baseline by day 8, indicating loss of UCN-01 bioavailability. Immunostains of γH2AX and pChk1(S296) on serial tumor biopsies from four patients demonstrated an induction of DNA damage and Chk1 activation following irinotecan. However, Chk1 inhibition by UCN-01 was not observed in all tumors. Most tumors were basal-like (69 %), and carried mutations in TP53 (53 %). Median overall survival in patients with TP53 mutant tumors was poor compared to wild type (5.5 vs. 20.3 months, p = 0.004). This regimen had limited activity in TNBC. Inconsistent Chk1 inhibition was likely due to the pharmacokinetics of UCN-01. TP53 mutations were associated with a poor prognosis in metastatic TNBC.