gebhart/patrepeval huggingface dataset:
Modification of postural responses and step initiation: evidence for goal-directed postural interactions (1994)

1. In this study, the interaction between anticipatory postural adjustments for step initiation and automatic postural responses to an external perturbation were investigated by having subjects initiate a voluntary forward step while perturbed by a backward surface translation, which caused forward sway of the body. The postural adjustments for step initiation act to move the body center of mass (COM) forward, whereas the automatic postural responses act to move the COM backward to restore stance equilibrium. Because the postural behaviors are in opposition, we asked whether a temporal hierarchy exists in which automatic postural responses are executed to restore equilibrium and followed by stereotypic postural adjustments for step initiation, or whether the interaction between these two postural behaviors is more dynamic. 2. Lower extremity electromyographs (EMGs), ground reaction forces, and kinematics were recorded from 10 subjects during three conditions: to quantify the anticipatory postural adjustments for step initiation, subjects stepped forward as soon as they felt a proprioceptive cue; to quantify the automatic postural responses to perturbation, subjects maintained stance equilibrium in response to a backward surface translation under both feet; and to quantify the interaction between the postural adjustments for the voluntary step and the automatic responses to the perturbation, subjects were exposed to a backward surface translation and instructed to step forward as soon as they felt the platform begin to move. 3. The anticipatory adjustments for step initiation included tibialis activation [stance limb = 163 +/- 28 (SE) ms; swing limb = 173 +/- 33 ms] and soleus inhibition resulting in center of foot pressure (COP) moving backward and lateral toward the swing limb to propel the COM forward over the stance limb. Subsequently, activation of the swing limb gastrocnemius resulted in heel-off. In contrast, the automatic postural adjustments for maintenance of stance equilibrium during a backward surface translation included activation of soleus and gastrocnemius (104 +/- 23 ms and 115 +/- 14 ms, respectively) resulting in a symmetrical forward displacement of the COP that moved the COM back to its original position with respect to the feet. 4. When a forward step was initiated in response to the translation, the automatic postural responses were reduced in amplitude bilaterally in soleus and in the stance limb gastrocnemius. When present the postural response occurred at the same latency when the goal was to initiate a step as when the goal was to maintain standing.(ABSTRACT TRUNCATED AT 400 WORDS)
Mirage: a coherent distributed shared memory design (1989)

Shared memory is an effective and efficient paradigm for interprocess communication. We are concerned with software that makes use of shared memory in a single site system and its extension to a multimachine environment. Here we describe the design of a distributed shared memory (DSM) system called Mirage developed at UCLA. Mirage provides a form of network transparency to make network boundaries invisible for shared memory and is upward compatible with an existing interface to shared memory. We present the rationale behind our design decisions and important details of the implementation. Mirage's basic performance is examined by component timings, a worst case application, and a “representative” application. In some instances of page contention, the tuning parameter in our design improves application throughput. In other cases, thrashing is reduced and overall system performance improved using our tuning parameter.
Altered Nociceptive Neuronal Circuits After Neonatal Peripheral Inflammation (2000)

Nociceptive neuronal circuits are formed during embryonic and postnatal times when painful stimuli are normally absent or limited. Today, medical procedures for neonates with health risks can involve tissue injury and pain for which the long-term effects are unknown. To investigate the impact of neonatal tissue injury and pain on development of nociceptive neuronal circuitry, we used an animal model of persistent hind paw peripheral inflammation. We found that, as adults, these animals exhibited spinal neuronal circuits with increased input and segmental changes in nociceptive primary afferent axons and altered responses to sensory stimulation.
Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons (2003)

Dopamine is believed to contribute to the degeneration of dopamine-containing neurons in the brain. However, whether dopamine affects the survival of other neuronal populations has remained unclear. Here we document that mice with persistently elevated extracellular dopamine, resulting from inactivation of the dopamine transporter gene, sporadically develop severe symptoms of dyskinesia concomitant with apoptotic death of striatal dopamine-responsive gamma-aminobutyric acidergic neurons. Chronic inhibition of dopamine synthesis prevents the appearance of motor dysfunction. The neuronal death is associated with overactivation of dopaminergic signaling as evidenced by the robust up-regulation of striatal DeltaFosB, cyclin-dependent kinase 5, and p35. Moreover, hyperphosphorylation of the tau protein, a phenomenon associated with the activation of cyclin-dependent kinase 5 in several neurodegenerative disorders, is observed in symptomatic mice. These findings provide in vivo evidence that, in addition to its proposed role in the degeneration of dopamine neurons, dopamine can also contribute to the selective death of its target neurons via a previously unappreciated mechanism.
Platelets can contain SARS-CoV-2 RNA and are hyperactivated in COVID-19 (2020)

ABSTRACT Rationale In addition to the overwhelming lung inflammation that prevails in COVID-19, hypercoagulation and thrombosis contribute to the lethality of subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Platelets are chiefly implicated in thrombosis. Moreover, they can interact with viruses and are an important source of inflammatory mediators. While a lower platelet count is associated with severity and mortality, little is known about platelet function during COVID-19. Objective To evaluate the contribution of platelets to inflammation and thrombosis in COVID-19 patients. Methods and Results We document the presence of SARS-CoV-2 RNA in platelets of COVID-19 patients. Exhaustive assessment of cytokines in plasma and in platelets revealed the modulation of platelet-associated cytokine levels in COVID-19, pointing to a direct contribution of platelets to the plasmatic cytokine load. Moreover, we demonstrate that platelets release their alpha- and dense-granule contents and phosphatidylserine-exposing extracellular vesicles. Functionally, platelets were hyperactivated in COVID-19 subjects, with aggregation occurring at suboptimal thrombin concentrations. Furthermore, platelets adhered more efficiently onto collagen-coated surfaces under flow conditions. Conclusions These data suggest that platelets could participate in the dissemination of SARS-CoV-2 and in the overwhelming thrombo-inflammation observed in COVID-19. Thus, blockade of platelet activation pathways may improve outcomes in this disease. KEY POINTS Platelets are a source of inflammatory cytokines and degranulate in COVID-19 Platelets contain SARS-CoV-2 RNA molecules and are prone to activation in COVID-19 Subject terms Infectious diseases/Emerging infectious diseases, SARS-CoV-2, COVID-19, Hematology, Platelets
A Very Late Viral Protein Triggers the Lytic Release of SV40 (2007)

How nonenveloped viruses such as simian virus 40 (SV40) trigger the lytic release of their progeny is poorly understood. Here, we demonstrate that SV40 expresses a novel later protein termed VP4 that triggers the timely lytic release of its progeny. Like VP3, VP4 synthesis initiates from a downstream AUG start codon within the VP2 transcript and localizes to the nucleus. However, VP4 expression occurs approximately 24 h later at a time that coincides with cell lysis, and it is not incorporated into mature virions. Mutation of the VP4 initiation codon from the SV40 genome delayed lysis by 2 d and reduced infectious particle release. Furthermore, the co-expression of VP4 and VP3, but not their individual expression, recapitulated cell lysis in bacteria. Thus, SV40 regulates its life cycle by the later temporal expression of VP4, which results in cell lysis and enables the 50-nm virus to exit the cell. This study also demonstrates how viruses can generate multiple proteins with diverse functions and localizations from a single reading frame.
Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation (2016)

Myosin motors are the fundamental force-generating elements of muscle contraction. Variation in the human β-cardiac myosin heavy chain gene (MYH7) can lead to hypertrophic cardiomyopathy (HCM), a heritable disease characterized by cardiac hypertrophy, heart failure, and sudden cardiac death. How specific myosin variants alter motor function or clinical expression of disease remains incompletely understood. Here, we combine structural models of myosin from multiple stages of its chemomechanical cycle, exome sequencing data from two population cohorts of 60,706 and 42,930 individuals, and genetic and phenotypic data from 2,913 patients with HCM to identify regions of disease enrichment within β-cardiac myosin. We first developed computational models of the human β-cardiac myosin protein before and after the myosin power stroke. Then, using a spatial scan statistic modified to analyze genetic variation in protein 3D space, we found significant enrichment of disease-associated variants in the converter, a kinetic domain that transduces force from the catalytic domain to the lever arm to accomplish the power stroke. Focusing our analysis on surface-exposed residues, we identified a larger region significantly enriched for disease-associated variants that contains both the converter domain and residues on a single flat surface on the myosin head described as the myosin mesa. Notably, patients with HCM with variants in the enriched regions have earlier disease onset than patients who have HCM with variants elsewhere. Our study provides a model for integrating protein structure, large-scale genetic sequencing, and detailed phenotypic data to reveal insight into time-shifted protein structures and genetic disease.
Inducible NO Synthase–Dependent<i>S</i>-Nitrosylation and Activation of Arginase1 Contribute to Age-Related Endothelial Dysfunction (2007)

Endothelial function is impaired in aging because of a decrease in NO bioavailability. This may be, in part, attributable to increased arginase activity, which reciprocally regulates NO synthase (NOS) by competing for the common substrate, L-arginine. However, the high Km of arginase (>1 mmol/L) compared with NOS (2 to 20 micromol/L) seemingly makes direct competition for substrate unlikely. One of the mechanisms by which NO exerts its effects is by posttranslational modification through S-nitrosylation of protein cysteines. We tested the hypothesis that arginase1 activity is modulated by this mechanism, which serves to alter its substrate affinity, allowing competition with NOS for L-arginine. We demonstrate that arginase1 activity is altered by S-nitrosylation, both in vitro and ex vivo. Furthermore, using site-directed mutagenesis we demonstrate that 2 cysteine residues (C168 and C303) are able to undergo nitrosylation. S-Nitrosylation of C303 stabilizes the arginase1 trimer and reduces its Km value 6-fold. Finally, arginase1 nitrosylation is increased (and thus its Km decreased) in blood vessels from aging rats, likely contributing to impaired NO bioavailability and endothelial dysfunction. This is mediated by inducible NOS, which is expressed in the aging endothelium. These findings suggest that S-nitrosylated arginase1 can compete with NOS for L-arginine and contribute to endothelial dysfunction in the aging cardiovascular system.
Replacing Alkoxy Groups with Alkylthienyl Groups: A Feasible Approach To Improve the Properties of Photovoltaic Polymers (2011)

Eine andere Dimension: Zwei neuartige zweidimensionale konjugierte Polymere wurden hergestellt und mit alkoxylierten Analoga verglichen. Die Ergebnisse zeigen, dass PBDTTT-C (links) bessere photovoltaische Eigenschaften aufweist als PBDTTT-C-T (rechts) und die 2D-Strukturen somit zum Aufbau von Photovoltaikpolymeren geeignet sind. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Glutamine-enriched Intravenous Feedings Attenuate Extracellular Fluid Expansion After a Standard Stress (1991)

A double-blind, randomized controlled trial was performed to determine the effect of glutamine (GLN)-enriched intravenous feedings on the volume and distribution of body fluids in catabolic patients. Subjects with hematologic malignancies in remission underwent a standard treatment of high-dose chemotherapy and total body irradiation before bone marrow transplantation. After completion of this regimen, they were randomized to receive either standard parenteral nutrition (STD, n = 10) or an isocaloric, isonitrogenous nutrient solution enriched with crystalline L-glutamine (0.57 g/kg/day, GLN, n = 10). Extracellular water (ECW) and total body water (TBW), determined by bromide and heavy water dilution techniques, were measured before the conditioning treatment and after termination of the intravenous feedings that were administered for 27 +/- 1 days. In addition electrical resistance (R, in ohms, omega) and reactance (Xc, omega) of the body to a weak alternating current were measured at these time points. Both study groups were comparable for age, weight, height, sex, and diagnosis. Initial TBW was highly related to electrical resistance (r = -0.93, p less than 0.001). After conditioning therapy, bone marrow infusion, and intravenous feedings, a 20% expansion in ECW was observed in the STD group (ECW: 18.0 +/- 1.1 L vs. 14.9 +/- 1.0, p = 0.012), and this fluid retention was associated with a marked decrease in electrical resistance (R: 514 +/- 28 omega vs. 558 +/- 26, p less than 0.05). In contrast the extracellular fluid compartment in patients receiving GLN-supplementation did not change (ECW: 15.8 +/- 0.9 L vs. 15.4 +/- 0.8, p = 0.49), and the body's resistance was maintained (R: 552 +/- 27 omega vs. 565 +/- 23, p = 0.42). Expansion of ECW could not be related to differences in fluid or sodium intake, or to the use of diuretics or steroids. Patients receiving the STD solution, however, exhibited a greater number of positive microbial cultures (p less than 0.01) and a higher rate of clinical infection compared with the GLN patients (5/10 vs. 0/10, p less than 0.05); the fluid expansion in infected STD patients was greater compared with uninfected individuals (delta ECW: + 5.0 +/- 1.4 vs. 0.7 +/- 0.5, p = 0.007). In this model of catabolic stress, fluid retention and expansion of the extracellular fluid compartment commonly observed after standard total parenteral nutrition can be attenuated by administering glutamine-supplemented intravenous feedings, possibly by protecting the host from microbial invasion and associated infection.
<title>Infrared Imaging Techniques For Flaw Detection In Composite Materials</title> (1983)

With the development of the new super strength lightweight composite materials, flaw and void detection in the various layers have become of major importance. Special infrared imaging techniques have been developed to show these voids. Included in these nondestructive methods are active steady state, active pulsed, and fast recording with slow playback of infrared images. Emissivity correction techniques have also been considered. Considerable time can be saved by using an imaging system since the size and shape of a defect or void is known at a glance. With video recording, documentation is achieved and further analysis is also possible without tieing up the part. Growth or changes of marginal flaws or voids can be traced during the manufacturing process, noting if they increase to the point of nonacceptance. An 8-13μ infrared scanner compatible with a video recorder and a line integrator proved most effective. Colorizing the image also made the flaw visualization easier.
Effect of gender, body composition, and equilibration time on the 2H-to-18O dilution space ratio (1992)

Physiological sources of variation in the 2H-to-18O dilution space ratio (DSR) were examined in 34 males and 20 females (4-78 yr; 14.7-143.2 kg; 1.8-61.0% body fat). Dilution spaces were obtained by time 0 extrapolation of isotope washout over 10-14 days, and body composition was obtained by underwater weight (adults) or bioelectrical impedance (children). The mean DSR was 1.050 +/- 0.015 (range 1.029-1.111), significantly higher (P < 0.001) than the traditionally assumed value of 1.029 based on exchange over 4 h. Use of the value 1.029 causes a systematic 8% overestimate of energy expenditure from doubly labeled water, relative to use of the value 1.05. The DSR was not related to body composition or age but was significantly higher (P < 0.05) in males (1.052 +/- 0.016) than in females (1.044 +/- 0.012). This gender effect was not explained by differences in the number of exchangeable hydrogens in the body. We conclude 1) variation in the 2H-to-18O DSR is not explained by body composition but is influenced by the chemical availability of exchangeable hydrogens to undergo exchange; 2) because the DSR is not easily predicted, use of the observed dilution spaces are recommended; 3) if a fixed DSR is used, values of 1.044 and 1.052 are recommended in females and males, respectively.
Synthetic Studis on Teleocidin III. Regioselective Introduction of Nitro Group at 4-Position of Substituted Indole Derivatives (1987)

Regioselectivities of nitration of substituted indolederivatives were studied and compound ?,containing three substituents similar to teleocidin B (L) was selectively synthesized.Potent tumor promoter teleocidin B ( L ) * and related indole alkaloids3 are one of the most interesting group of natural products for the synthetic chemists because of their challengable highly substituted indole skeletons.Recently, we found novel synthetic methods for direct introduction of substituents at benzene part of indole derivative^.^In our synthetic studies on teleocidin, nitrogen function 5
Comparative effects of xylazine and propofol on the urethral pressure profile of healthy dogs (1993)

The effects of 2 drugs, xylazine and propofol, on the urethral pressure profile were compared. Seven female dogs were sedated by administration of one drug, then the other, and urethral variables were measured. In the dogs sedated with propofol, the mean +/- SD, maximal urethral closure pressure (51 +/- 7.4 cm of H2O) was significantly (P < 0.05) higher than the value when dogs were sedated with xylazine (23.3 +/- 7.6 cm of H2O). Results were compared with those obtained by various authors, in particular for nonsedated dogs. It is concluded that propofol is a good drug for investigation of the urethral pressure profile, whatever its effect on maximal urethral closure pressure.
IEEE 802.11ax: Challenges and Requirements for Future High Efficiency WiFi (2016)

The popularity of IEEE 802.11 based wireless local area networks (WLANs) has increased significantly in recent years because of their ability to provide increased mobility, flexibility, and ease of use, with reduced cost of installation and maintenance. This has resulted in massive WLAN deployment in geographically limited environments that encompass multiple overlapping basic service sets (OBSSs). In this article, we introduce IEEE 802.11ax, a new standard being developed by the IEEE 802.11 Working Group, which will enable efficient usage of spectrum along with an enhanced user experience. We expose advanced technological enhancements proposed to improve the efficiency within high density WLAN networks and explore the key challenges to the upcoming amendment.
Polarization fluctuation dominated electrical transport processes of polymer-based ferroelectric field effect transistors (2012)

Ferroelectric field effect transistors (FE-FETs) consisting of tunable dielectric layers are utilized to investigate interfacial transport processes. Large changes in the dielectric constant as a function of temperature are observed in FE-FETs in conjunction with the ferroelectric to paraelectric transition. The devices offer a test bed to evaluate specific effects of polarization on the electrical processes. FE-FETs have dominant contributions from polarization fluctuation rather than static dipolar disorder prevalent in high $k$ paraelectric dielectric-based FETs. Additionally, photo-excitation measurements in the depletion mode reveal clear features in the FET response at different temperatures, indicative of different transport regimes.
Spectral and Spatial Classification of Hyperspectral Images Based on Random Multi-Graphs (2018)

Hyperspectral image classification has been acknowledged as the fundamental and challenging task of hyperspectral data processing. The abundance of spectral and spatial information has provided great opportunities to effectively characterize and identify ground materials. In this paper, we propose a spectral and spatial classification framework for hyperspectral images based on Random Multi-Graphs (RMGs). The RMG is a graph-based ensemble learning method, which is rarely considered in hyperspectral image classification. It is empirically verified that the semi-supervised RMG deals well with small sample setting problems. This kind of problem is very common in hyperspectral image applications. In the proposed method, spatial features are extracted based on linear prediction error analysis and local binary patterns; spatial features and spectral features are then stacked into high dimensional vectors. The high dimensional vectors are fed into the RMG for classification. By randomly selecting a subset of features to create a graph, the proposed method can achieve excellent classification performance. The experiments on three real hyperspectral datasets have demonstrated that the proposed method exhibits better performance than several closely related methods.