gebhart/patrepeval huggingface dataset:
Stroke Survivors Scoring Zero on the NIH Stroke Scale Score Still Exhibit Significant Motor Impairment and Functional Limitation (2014)

Objective. To determine the National Institutes of Health Stroke Scale's (NIHSS's) association with upper extremity (UE) impairment and functional outcomes. Design. Secondary, retrospective analysis of randomized controlled trial data. Setting. Not applicable. Participants. 146 subjects with stable, chronic stroke-induced hemiparesis. Intervention. The NIHSS, the UE Fugl-Meyer (FM), and the Arm Motor Ability Test (AMAT) were administered prior to their participation in a multicenter randomized controlled trial. Main Outcome Measures. The NIHSS, FM, and AMAT. Results. The association between the NIHSS and UE impairment was statistically significant (P = -0.204; p = 0.014) but explained less than 4% of the variance among UE FM scores. The association between NIHSS total score and function as measured by the AMAT was not statistically significant (P = -0.141; p = 0.089). Subjects scoring a "zero" on the NIHSS exhibited discernible UE motor deficits and varied scores on the UE FM and AMAT. Conclusion. While being used in stroke trials, the NIHSS may have limited ability to discriminate between treatment responses, even when only a relatively narrow array of impairment levels exists among patients. Given these findings, NIHSS use should be restricted to acute stroke studies and clinical settings with the goal of reporting stroke severity.
Learning Video-Story Composition via Recurrent Neural Network (2018)

In this paper, we propose a learning-based method to compose a video-story from a group of video clips that describe an activity or experience. We learn the coherence between video clips from real videos via the Recurrent Neural Network (RNN) that jointly incorporates the spatial-temporal semantics and motion dynamics to generate smooth and relevant compositions. We further rearrange the results generated by the RNN to make the overall video-story compatible with the storyline structure via a submodular ranking optimization process. Experimental results on the video-story dataset show that the proposed algorithm outperforms the state-of-the-art approach.
Service Life Extension of the ISS Propulsion System Elements (2015)

The International Space Station (ISS) is a result of international collaboration in building a sophisticated laboratory of an unprecedented scale in Low Earth Orbit. After a complex assembly sequence spanning over a decade, some of the early modules launched at the beginning of the program would reach the end of their certified lives, while the newer modules were just being commissioned into operation. To maximize the return on global investments in this one-of-a-kind orbiting platform that was initially conceived for a service life until 2016, it is essential for the cutting edge research on ISS to continue as long as the station can be sustained safely in orbit. ISS Program is assessing individual modules in detail to extend the service life of the ISS to 2024, and possibly to 2028. Without life extension, Functional Cargo Block (known by its Russian acronym as FGB) and the Service Module (SM), two of the early modules on the Russian Segment, would reach the end of their certified lives in 2013 and 2015 respectively. Both FGB and SM are critical for the propulsive function of the ISS. This paper describes the approach used for the service life extension of the FGB propulsion system. Also presented is an overview of the system description along with the process adopted for developing the life test plans based on considerations of system failure modes, fault tolerance and safety provisions. Tests and analyses performed, important findings and life estimates are summarized. Based on the life extension data, FGB propulsion system, in general, is considered ready for a service life until 2028.
Dinuclear Alkylamine Platinum(<scp>II</scp>) Complexes of [1,2‐Bis(4‐fluorophenyl)ethylenediamine]platinum(<scp>II</scp>): Influence of Endocytosis and Copper and Organic Cation Transport Systems on Cellular Uptake (2006)

Various possible pathways for the uptake of cationic alkylamine platinum(II) complexes into the MCF-7 breast cancer cells were studied with di[meso-1,2-bis(4-fluorophenyl)ethylenediamine]di[sulfinylbis(methane)-S][mu-1,6-diaminohexaneN:N']diplatinum(II) disulfate (m-4F-PtDMSO-DAH) as an example. It was demonstrated that m-4F-PtDMSO-DAH competed neither for the copper transporter nor the organic cation transporters (OCT and OATP). Instead, adsorptive endocytosis by macropinocytosis played an essential role. Inhibitors of this processes such as amiloride, N-ethyl-N-isopropylamiloride (EIPA), wortmannin, and cytochalasin D decreased the intracellular uptake of m-4F-PtDMSO-DAH dramatically. These results support the understanding of the pharmacological behavior of this promising drug family, which showed no cross resistance with cisplatin.
Latency In vitro using Irradiated Herpes Simplex Virus (1981)

Human embryonic fibroblasts infected with u.v.-irradiated herpes simplex virus type 2 (HSV-2, strain 186) and maintained at 40.5 degrees C did not yield detectable virus. Virus synthesis was induced by temperature shift-down to 36.5 degrees C. The induced virus grew very poorly and was inactivated very rapidly at 40.5 degrees C. Non-irradiated virus failed to establish latency at 40.5 degrees C in infected cells. Enhanced reactivation of HSV-2 was observed when latently infected cultures were superinfected with human cytomegalovirus (HCMV) or irradiated with a small dose of u.v. light at the time of temperature shift-down. HCMV did not enhance synthesis of HSV-2 during a normal growth cycle but did enhance synthesis of u.v.-irradiated HSV-2. These observations suggest that in this in vitro latency system, some HSV genomes damaged by u.v. irradiation were maintained in a non-replicating state without being destroyed or significantly repaired.
DNA methylation in mammalian development and disease (2005)

Epigenetic modification of the cytosine base of DNA by its methylation introduced the possibility that beyond the inherent information contained within the nucleotide sequence there was an additional layer of information added to the underlying genetic code. DNA methylation has been implicated in a wide range of biological functions, including an essential developmental role in the reprogramming of germ cells and early embryos, the repression of endogenous retrotransposons, and a generalized role in gene expression. Special functions of DNA methylation include the marking of one of the parental alleles of many imprinted genes, a group of genes essential for growth and development in mammals with a unique parent-of-origin expression pattern, a role in stabilizing X-chromosome inactivation, and centromere function. In this regard, it is not surprising that errors in establishing or maintaining patterns of methylation are associated with a diverse group of human diseases and syndromes.
Deeplive: QoE Optimization for Live Video Streaming through Deep Reinforcement Learning (2019)

A new broad of video services that support live streaming has become tremendously popular in recent years. Compared with traditional video-on-demand (VOD) services, live video streaming has much higher requirements on Quality-of-Experience (QoE), including low rebuffering, high definition, low latency and low bitrate oscillations. While previous adaptive bitrate algorithms (ABR) solely optimize bitrate for ensuring QoE of VOD, live video streaming has a larger decision space, making the optimization problem more difficult to solve. We propose Deeplive, which maximizes QoE through deep reinforcement learning (DRL), so it does not rely on fixed rules. To accelerate the training process of Deeplive, we further propose optimization including window completion with historical data and quick-start with rate-based algorithm. We compare Deeplive with other advanced ABR algorithms in a frame-level dynamic adaptive video streaming simulator using different network traces, QoE definitions, and video categories. In all experiments, we find that Deeplive not only has significant improvement in training time, but also shows an average of 15-55% improvement on QoE than the state-of-the-art ABR algorithms.
Repair of the Deviated Nasal Tip (1989)

Deviated septal cartilage is, on occasion, impossible to reposition and maintain in the midline. Camouflage techniques are most useful to create the illusion of a straight nose. Alar cartilage asymmetries require a good exposure either by a rim incision with full delivery or via the external approach. Balancing of the alar cartilage is achieved by excision and replacement of cartilage either from remaining alar cartilage or by harvesting cartilage from either the septum or ear conchal cartilage
<i>Mycoplasma hyopneumoniae</i>Potentiation of Porcine Reproductive and Respiratory Syndrome Virus-Induced Pneumonia (1999)

An experimental model that demonstrates a mycoplasma species acting to potentiate a viral pneumonia was developed. Mycoplasma hyopneumoniae, which produces a chronic, lymphohistiocytic bronchopneumonia in pigs, was found to potentiate the severity and the duration of a virus-induced pneumonia in pigs. Pigs were inoculated with M. hyopneumoniae 21 days prior to, simultaneously with, or 10 days after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV), which induces an acute interstitial pneumonia in pigs. PRRSV-induced clinical respiratory disease and macroscopic and microscopic pneumonic lesions were more severe and persistent in M. hyopneumoniae-infected pigs. At 28 or 38 days after PRRSV inoculation, M. hyopneumoniae-infected pigs still exhibited lesions typical of PRRSV-induced pneumonia, whereas the lungs of pigs which had received only PRRSV were essentially normal. On the basis of macroscopic lung lesions, it appears that PRRSV infection did not influence the severity of M. hyopneumoniae infection, although microscopic lesions typical of M. hyopneumoniae were more severe in PRRSV-infected pigs. These results indicate that M. hyopneumoniae infection potentiates PRRSV-induced disease and lesions. Most importantly, M. hyopneumoniae-infected pigs with minimal to nondetectable mycoplasmal pneumonia lesions manifested significantly increased PRRSV-induced pneumonia lesions compared to pigs infected with PRRSV only. This discovery is important with respect to the control of respiratory disease in pigs and has implications in elucidating the potential contribution of mycoplasmas in the pathogenesis of viral infections of other species, including humans.
Enhanced Recovery Speed of Nanostructured ZnO Photodetectors Using Nanobelt Networks (2012)

ZnO nanowire (NW) UV photodetectors (PDs) have high sensitivity, while their long recovery time is an important limitation for practical applications. We demonstrated that the recovery time of nanostructured ZnO PDs can be significantly improved using the nanobelt (NB) network. The NB-network PDs are fabricated by only one step without tedious and costly lithography processes. As compared with a recovery time of 32.95 s in the single NB-based PD, a fast recovery time of 0.53 s observed in the NB-network PDs is achieved due to the existence of the NB-NB junction barriers. As the junction barriers accounting for the poor conductivity of NB networks hinder the electron transport, the dark current of the NB-network PDs is two orders of magnitude lower than that of the single NB-based PDs. The NB networks can be applicable to the building structures for nanostructured ZnO-based light-sensing applications with wafer-scale uniformity without compromising the unique photodetection properties exclusively provided by high surface-to-volume ratio and reduced dimensionality of an individual NW/NB.
Evaluation of the toxicity effects of silk fibroin on human lymphocytes and monocytes (2018)

Silk fibroin nanoparticles (SFNPs) as a natural polymer have been utilized in biomedical applications such as suture, tissue engineering-based scaffolds, and drug delivery carriers. Since there is little data regarding the toxicity effects on different cells and tissues, we aimed to determine the toxicity mechanisms of SFNPs on human lymphocytes and monocytes based on reliable methods. Our results showed that SFNPs (0.5, 1, and 2 mg/mL) induced oxidative stress via increasing reactive oxygen species production, mitochondrial membrane potential (∆Ψ) collapse, which was correlated to cytochrome c release and Adenosine diphosphate (ADP)/Adenosine tri phosphate (ATP) ratio increase as well as lysosomal as another toxicity mechanism, which led to cytosolic release of lysosomal digestive proteases, phosphor lipases, and apoptosis signaling. Taken together, these data suggested that SFNPs toxicity was associated with mutual mitochondrial/lysosomal cross-talk and oxidative stress on human lymphocytes and monocytes with activated apoptosis signaling.
Analysis of occluding contour (1977)

Abstract Almost nothing can be deduced about a general three-dimensional surface given only its occluding contours in an image, yet contour information is easily and effectively used by us to infer the shape of a surface. Therefore, implicit in the perceptual analysis of occluding contour must lie various assumptions about the viewed surfaces. The assumptions that seem most natural are (a) that the distinction between convex and concave segments reflects real properties of the viewed surface; and (b) that contiguous portions of contour arise from contiguous parts of the viewed surface – i. e. there are no invisible obscuring edges. It is proved that, for smooth surfaces, these assumptions are essentially equivalent to assuming that the viewed surface is a generalized cone. Methods are defined for finding the axis of such a cone, and for segmenting a surface constructed of several cones into its components, whose axes can then be found separately. These methods provide one link between an uninterpreted figure extracted from an image, and the 3-D representation theory of Marr & Nishihara (1977).
AC Loss Characteristics in kHz frequency band of a High Temperature Superconductor Coil for a Wireless Power Transmission System (2017)

Improvement of transmission efficiency is an important issue in a large-capacity wireless power transmission (WPT) system using copper coils for automobiles and electric railways. We have investigated the application of a high-temperature superconducting (HTS) coil to a high-power WPT system operating in the frequency region of 10 kHz. We measured the transport current losses of GdBCO and Bi2223 tapes and the total ac losses of GdBCO and Bi2223 coils in the kilohertz frequency band. We analyzed the current distribution within the tape using a finite element method (FEM) program. When the current load factor was low and the frequency was above 1 kHz, the ac losses per cycle increased with the frequency. This is because the eddy current loss in stabilized layers was larger than the hysteresis loss at the frequency of above 1 kHz. One the other hand, the ac losses per cycle were constant regardless of the frequency at the high-current load factor. This is because the hysteresis loss was larger than the eddy current loss regardless of the frequency. We investigated the maximum transmission efficiency at a resonance frequency in an HTS WPT system and a Cu WPT system. Although the quality factor of the HTS coil gradually decreased with the frequency and the operating current, the maximum transmission efficiency of the HTS WPT system was much higher than that of the Cu WPT system. We believe that the HTS coil is suitable for a large-capacity and high-efficiency WPT system in the frequency region below 10 kHz.
Activation of Adenosine A<sub>2a</sub> Receptors Inhibits Mast Cell Degranulation and Mast Cell‐Dependent Vasoconstriction (2000)

ABSTRACT Adenosine and inosine accumulate in tissue during periods of ischemia and both molecules have been shown to degranulate mast cells in the hamster cheek pouch via activation of an A 3 receptor. An A 2 ‐mediated inhibitory action of adenosine on mast cell degranulation has also been reported (16), and the objective of this research was to investigate the role of adenosine A 2 receptors in modulating inosine‐induced mast cell degranulation and subsequent vasoconstriction of microvessels. Methods: Cheek pouches of the Golden hamster were prepared for in vivo microscopy. Adenosine, inosine, and other agents were applied either globally in the superfusion solution or to selected regions of the tissue by pipette. Results: Micropipette application of 10 −4 M inosine to periarteriolar mast cells caused a vasoconstriction and an associated mast cell degranulation in 71% of the arterioles tested. The average diameter reduction was 29 ± 5%. To establish a modulatory role for the A 2 receptor, low doses of adenosine (100 nM and 10 nM) were applied globally via the superfusion prior to inosine stimulation. This adenosine pretreatment resulted in a decrease in the incidence of the inosineinduced vasoconstriction (17% and 31%), as well as smaller constrictions (0.5 ± 1% and 7 ± 3%). Mast cell degranulation was also reduced by pretreatment with adenosine, as evidenced by a decreased number of mast cells exhibiting ruthenium red dye uptake. The inhibitory effect of adenosine could be eliminated by pretreatment with the nonselective A 1 /A 2 antagonist 8‐( p ‐sulfophenyl) theophylline, which restored the inosine‐induced responses to control values. To demonstrate that the effect was A 2α ‐mediated, vessels were pretreated with the selective A 2α agonist 2‐[4‐(2‐carboxyethyl) phenethylamino]‐5′‐ N ‐ethylcarboxamidoadenosine (CGS21680). Following this treatment, constriction in response to microapplication of inosine (10 −4 M) occurred in only 11% of the vessels tested; the average constriction was reduced to 2 ± 2% and no mast cell degranulation was observed. Conclusions: We conclude that mast cell degranulation can be inhibited via activation of an adenosine A 2α receptor; which activation occurs at a lower concentration of adenosine than stimulatory A 3 receptor activation. This finding may have implications for the pathology of ischemia.
Impedance spectroscopy and electrical modeling of electrowetting on dielectric devices (2015)

Using impedance spectroscopy, we have determined models for the elements which determine the ac electrical behavior in electrowetting on dielectric (EWOD) systems. Three commonly used EWOD electrode configurations were analyzed. In each case, the impedance can be modeled by a combination of elements, including the solution resistance, the capacitance of the dielectric layer, and the constant phase impedance of the electrode double layers. The sensitivity of the system's impedance to variations in the electrowetted area is also analyzed for these common configurations. We also demonstrate that the impedance per unit area of typical EWOD systems is invariant to bias voltage.
Near-optimal instruction selection on dags (2008)

Instruction selection is a key component of code generation. High quality instruction selection is of particular importance in the embedded space where complex instruction sets are common and code size is a prime concern. Although instruction selection on tree expressions is a well understood and easily solved problem, instruction selection on directed acyclic graphs is NP-complete. In this paper we present NOLTIS, a near-optimal, linear time instruction selection algorithm for DAG expressions. NOLTIS is easy to implement, fast, and effective with a demonstrated average code size improvement of 5.1% compared to the traditional tree decomposition and tiling approach.
Increased lipid peroxidation correlates with platelet activation but not with markers of endothelial cell and blood coagulation activation in patients with antiphospholipid antibodies (2001)

Recent studies have shown that patients with antiphospholipid antibodies (aPL) have increased lipid peroxidation. We evaluated the urinary excretion of 11-dehydro thromboxane B2 (11-DH-TXB(2) and isoprostane F(2alpha)III (IPF(2alpha)III), reflecting platelet activation and lipid peroxidation in vivo, and plasma soluble markers of endothelial cell, platelet and blood coagulation activation: soluble vascular cell adhesion molecule-1 (sVCAM-1), P- and E-selectin (sPsel and sEsel), F1 + 2 fragment of prothrombin (F1 + 2), thrombin-antithrombin complexes (TAT) and D-Dimer (DD). We studied 79 patients with aPL (47 with previous thrombosis), 45 healthy volunteers (normal controls, NC), 12 patients with systemic lupus erythematosus (SLE) without aPL and a thrombosis control group (TCG) without thrombophilia (n = 16). Urinary levels (mean, range) of eicosanoids and isoeicosanoids were significantly increased in 39 patients with aPL compared with 25 NC, 11-DH-TXB(2) 164.0 ng/mmol creatinine (9.5-1162.8) versus 43.4 ng/mmol creatinine (4.2-87.6), P < 0.001; IPF(2alpha)III 56.9 pg/mg creatinine (5.5-388.7) versus 27.0 pg/mg creatinine (4.6-87.6), P = 0.03. Both metabolites were significantly correlated (rho = 0.49, P = 0.014), but none correlated with any clinical manifestation or antibody profile. The aPL group presented increased levels of sPsel, sEsel, sVCAM-1, TAT, F1 + 2 and DD, but any soluble marker correlated with IPF2alphaIII. Urinary 11-DH-TXB(2) correlated with sPsel (rho = 0.39, P = 0.04). Compared with SLE controls, the SLE group with aPL had higher levels of F1 + 2. Plasma levels of F1 + 2 and DD were significantly increased and a trend to higher sPsel was found in aPL patients with thrombosis compared with the TCG. Platelet activation, lipid peroxidation and blood coagulation activation seem to be important in the pathophysiology of antiphospholipid syndrome.
Chemistry and catalytic properties of ruthenium and osmium complexes. 3. Development of highly active systems for the homogeneous hydrogenation of aldehydes and ketones (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry and catalytic properties of ruthenium and osmium complexes. 3. Development of highly active systems for the homogeneous hydrogenation of aldehydes and ketonesRoberto A. Sanchez-Delgado, Norma Valencia, Rosalinda Marquez-Silva, Antida Andriollo, and Miriam MedinaCite this: Inorg. Chem. 1986, 25, 8, 1106–1111Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ic00228a010https://doi.org/10.1021/ic00228a010research-articleACS PublicationsRequest reuse permissionsArticle Views509Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts