gebhart/patrepeval huggingface dataset:
Regulation of growth hormone gene expression: synergistic effects of thyroid and glucocorticoid hormones. (1977)

Cultured rat pituitary cells (GC) respond to thyroid and glucocorticoid hormones by increases in growth hormone production and growth hormone mRNA. When these cells are transferred from medium containing normal animal serum (with 1.8 mug of thyroxine per dl) to a medium containing serum from a thyroidectomized calf, "hypothyroid medium" (with no detectable thyroid hormone), growth hormone production decreases markedly. In cells maintained for 5 days in hypothyroid medium, triiodothyronine induces within 50 hr a 17-fold increase in growth hormone production whereas glucocorticoids, during the same time, produce a negligible (3-fold or less) stimulation. In combination, the two hormones promote a 45-fold stimulation. In all instances the changes in growth hormone production are paralleled by changes in the levels of growth hormone mRNA as measured by cell-free translation. The transfer to hypothyroid medium and the hormonal induction do not affect the relative activities of other mRNAs whose products are detectable on polyacrylamide gels. These studies indicate that thyroid hormone can be an activator of the expression of the growth hormone gene. The results also show that triiodothyronine controls the magnitude of the effect of glucocorticoids on growth hormone mRNA, and provide a model for "permissive" triiodothyronine action. The synergistic effect of these two classes of hormone suggests that they increase levels of growth hormone mRNA by different mechanisms.
Foreword (1990)

Foreword Get access Elspeth Smith Elspeth Smith Aberdeen, Scotland Search for other works by this author on: Oxford Academic PubMed Google Scholar European Heart Journal, Volume 11, Issue suppl_E, January 1990, Page 1, https://doi.org/10.1093/eurheartj/11.suppl_E.1 Published: 01 August 1990
A technique for obtaining basal corneal epithelial cells. (1985)

A technique has been developed for obtaining a cell suspension enriched (89%) in basal corneal epithelial cells. Eleven millimeter corneal buttons were removed and placed in culture medium containing low (10 microM) calcium. The posterior half of the stroma was removed with forceps. Three superficial cuts were made with a Bard-Parker blade on the anterior half of the cornea, which was then incubated for 18 hr at 35 degrees C. Nonadherent cells were brushed off after the incubation and basal cells were harvested after a 1-hr incubation in Dispase II. Cell viability estimated by Erythrocin beta exclusion was 90%. Further evidence of viability was that the cells adhered to their native substrate, the denuded basal lamina. The authors protocol provides a method for analyzing the biochemistry of a known population of epithelial cells and makes available a defined source of cells for culture.
Characterization of Unconventional Engineering Solutions for Superjunction Devices (2006)

Superjunction devices are nowadays fabricated based on multi-epitaxy depositions of n-type layers and subsequent masked p-implantations. Improving the performance of the devices requires the optimization of the fabrication process. In this paper, two new approaches to the superjunction technology, based on proton implantations and on the implantation of boron at a very high energies, have been characterized by dopant profiling techniques and compared with process simulation
An Interactive Cellular Automata Music Application in Cocoa (2004)

Certain cellular automata have visual characteristics that make interactive computer music performance possible.An application has been written using the Cocoa objectoriented language with Objective-C that allows the performer or composer to control which columns of cells are enabled for mapping to pitches and durations as the program is running.Other parameters that can be changed interactively include tempo, enable/disable for sixteen MIDI channels, and pitch transposition to any degree for each MIDI channel.Changes made to control parameters during runs can be saved to file and used to play back a performance.An editing mode permits detailed control of all interactive parameters which saved to file can be used in the play mode to achieve a controlled rather than improvised performance of a composition.
Percutaneous Implantation of Aortic Valve Prostheses in Patients with Calcific Aortic Stenosis – Technical Advances (2007)

Due to the ageing population and the consequent increased prevalence of aortic stenosis,1 the management of this disease in elderly patients, especially when associated with complex co-morbidities, is becoming an important issue for physicians.
Physical Self-Assembly of Microstructures by Anisotropic Buckling (2002)

Physically self-assembled microstructures can be realized by utilizing the stress relief process in buckling that usually leads to the formation of random wrinkles. This physical self-assembly occurs when the wrinkle formation is guided by a periodic pattern on an elastomeric mold that is simply placed on the surface of a bilayer of metal on polymer, which is then heated above its glass-transition temperature (see Figure and inside cover).
<scp>C</scp> hina: Media System (2015)

For centuries, China stood as a leading civilization, outpacing the rest of the world in the arts and sciences. But in the nineteenth and early twentieth centuries, China was beset by civil unrest, major famines, military defeats, and foreign occupation. After World War II, the Communists, under Chairman Mao Zedong, founded the People's Republic of China (PRC) in 1949, which centralized control over almost every facet of Chinese life. After 1978, his successor, Deng Xiaoping, gradually introduced market‐oriented reforms and decentralized economic decision‐making. Political controls remain tight even while economic controls have continued to be relaxed under President Jiang Zemin (1993–2003), President Hu Jintao (2003–2012), and now President Xi Jinping (2012–).
Dual-wavelength transmitter for enhanced video performance over a passive optical network (2003)

RF carriers containing analog and/or digital video content drive a LiNbO/sub 3/ modulator fed by two closely spaced (/spl Delta//spl lambda/=1.6 nm) DFB lasers. This decreases the effective RIN at the receiver by 3 dB and improves the SBS suppression by 3 dB.
Network requirements for resource disaggregation (2016)

Traditional datacenters are designed as a collection of servers, each of which tightly couples the resources required for computing tasks. Recent industry trends suggest a paradigm shift to a disaggregated datacenter (DDC) architecture containing a pool of resources, each built as a standalone resource blade and interconnected using a network fabric.A key enabling (or blocking) factor for disaggregation will be the network - to support good application-level performance it becomes critical that the network fabric provide low latency communication even under the increased traffic load that disaggregation introduces. In this paper, we use a workload-driven approach to derive the minimum latency and bandwidth requirements that the network in disaggregated datacenters must provide to avoid degrading application-level performance and explore the feasibility of meeting these requirements with existing system designs and commodity networking technology.
Immunoglobulin class commitment exhibited by B lymphocytes separated according to surface isotype. (1981)

In order to determine the extent to which B cells exhibit class commitment, the isotype(s) secreted by individual B cells and their progeny was studied in relation to the isotype(s) expressed on the surface of the B cell. Both primary and secondary B cells were separated according to cell surface isotypes and analyzed under optimal stimulation conditions using the T-dependent splenic focus assay. From these studies the following conclusions conclude be made: a) essentially all mature primary B cells appear to express mu on their surface; b) accordingly, the primary B cell population appears to be devoid of B cells expressing solely IgG on their surface; c) the majority of primary B cells in the presence of optimal T cell help have the potential for multiple class production; d) the secretion of IgA coincides with that of IgM and not IgG in its synthesis by immature B cells; e) a substantial proportion of memory B cells bear mu on their surface; f) memory B cells that lack s-mu are unable to yield clones secreting IgM; and g) a substantial proportion of memory B cells have the potential for multiple class production.
Oracle Designer Handbook (1996)

From the Publisher:
This book offers a comprehensive system development method using Oracle's design tools. 
Develop applications that meet the needs of your organization. 
Make your software design and development process more accurate and flexible using this comprehensive handbook on Oracle Designer. 
Designer (formerly Designer/2000) is Oracle's powerful CASE tool that assists you in creating systems that reflect the business needs and requirements of your organization. Using Designer to capture and mange the voluminous data involved in application system development,you can develop better applicationson target and on budget. 
This unique handbook guides you through each step of the CASE Application Development Method (CADM),a methodology that integrates Designer into the development process. The author's complete exploration of the goals,processes,and deliverables for each step in the CADM process is balanced with practical how-to discussions based on actual experiences. 
Software designers and developers can use this guide to:


Build systems from the smallest to the largest using a comprehensive development method fully integrated with Designer Version 2. 1 Fine-tune finished product using Designer's robust features Design and build Web and Oracle Developer applications and Oracle8 objects Successfully manage a project using the tips and techniques of experts 


To quickly plan and build high-quality applications in less time,use Oracle Designer and the only officially Oracle-authorized book to explain it in detail: Oracle Designer Handbook,Second Edition.
A Taxonomic Study of Thermomonospora and Other Monosporic Actinomycetes (1984)

A large collection of Thermomonospora isolates and type or reference cultures, together with representatives of the genera Thermoactinomyces, Saccharomonospora, Micropolyspora and Actinomadura, were included in a numerical taxonomic study. The 113 strains were examined for 101 morphological, physiological and biochemical characters and data were analysed using simple matching (SSM ), Jaccard (SJ ) and pattern difference (DP ) coefficients with clustering by both single and unweighted pair group average algorithms. All of the analyses produced similar classifications which were little affected by test error, estimated at 1.1%. Thermomonospora strains formed two major clusters identified as Thm. chromogena and the white Thermomonospora group, respectively, while type strains of Acm. flexuosa, Mip. faeni and Thm. mesophila were well separated from one another and all major clusters. The low phenetic similarity between the two Thermomonospora clusters supports suggestions based on chemical data that Thm. chromogena may be better classified in a separate genus. Three subclusters were detected within the white Thermomonospora group and equated with the species Thm. fusca, Thm. curvata and Thm. alba. The Saccharomonospora cluster was heterogeneous and, although it included strains identified as Sam. viridis, Mip. caesia and Thermomonospora sp. (lilac), species could not be distinguished. The type strain of Thm. galeriensis shared the distinguishing characteristics of this cluster and should be regarded as a member of the genus Saccharomonospora. Only five strains of Thermoactinomyces were included, but they formed a cluster with an internal structure which supported a previous numerical classification of species in this genus. Wall chemotype and spore heat-resistance properties were consistent with generic identification. As a result of this study, five Thermomonospora spp. are recognized: Thm. chromogena comb. nov. nom. rev. (synonyms Actinobifida chromogena, Thm. falcata); Thm. mesophila; Thm. fusca sp. nov. nom. rev.; Thm. alba (synonym Thm. mesouviformis); Thm. curvata. The experimental data allowed the development of an identification scheme for these species and also provided tests to confirm generic identifications of other thermophilic actinomycete isolates.
Analysis of carbon soil content by using tagged neutron activation (2012)

Here we describe a prototype for non-destructive, in-situ, accurate and cost-effectively measurement procedure of carbon in soil based on neutron activation analysis using 14 MeV tagged neutron beam. This technology can be used for carbon baseline assessment on regional scale and for monitoring of its surface and depth storage due to the changes in agricultural practices undertaken in order to mitigate global climate change.
Four-dimensional magnetic resonance imaging for the determination of tumour movement and its evaluation using a dynamic porcine lung phantom (2007)

A method of four-dimensional (4D) magnetic resonance imaging (MRI) has been implemented and evaluated. It consists of retrospective sorting and slice stacking of two-dimensional (2D) images using an external signal for motion monitoring of the object to be imaged. The presented method aims to determine the tumour trajectories based on a signal that is appropriate for monitoring the movement of the target volume during radiotherapy such that the radiation delivery can be adapted to the movement. For evaluation of the 4D-MRI method, it has been applied to a dynamic lung phantom, which exhibits periodic respiratory movement of a porcine heart-lung explant with artificial pulmonary nodules. Anatomic changes of the lung phantom caused by respiratory motion have been quantified, revealing hysteresis. The results demonstrate the feasibility of the presented method of 4D-MRI. In particular, it enables the determination of trajectories of periodically moving objects with an uncertainty in the order of 1 mm.
A 4.2 kb/s low-delay speech coder with modified CELP (1997)

In this letter, we propose a low-delay speech coder at 4.2 kb/s. In the proposed coder, we remove short-term prediction and use three-tap long term prediction to exploit the speech redundancy. A "dual-decision" pitch estimation algorithm and an adaptive sinusoidal excitation codebook are introduced to improve the performance of the proposed coder. The synthesized speech of this coder has comparable quality to that of conventional CELP coders at similar bit rates, while it has a coding delay of only 5 ms.
Comparison of Different Crosslinking Methods for Preparation of Docetaxel-loaded Albumin Nanoparticles. (2015)

In the last step of desolvation method for preparation of albumin nanoparticles, glutaraldehyde (GA) is added to stabilize the newly formed nanoparticles. Due to undesirable effects of GA, the objective of this study was to evaluate alternative methods of crosslinking including ultraviolet (UV) irradiation, adding of glucose and combination of both methods. The nanoparticles were prepared by desolvation procedure. Final particle size, zeta potential, FTIR, scanning electron micrograph, cellular uptake and cell toxicity of nanoparticles crosslinked with UV and/or glucose were compared with commonly crosslinked nanoparticles with GA. Moreover, drug release and stability parameters of docetaxel-loaded albumin nanoparticles were investigated. Size of all nanoparticles prepared by different methods was in the same range (100-200 nm). Zeta potential showed the same results except for those treated with UV. The results of FTIR assay were the same for all groups. Although crosslinking by UV or glucose alone resulted in cytotoxic effects, combination of UV and glucose had less cytotoxic effects compared to GA. Cellular uptake of nanoparticles crosslinked with UV + glucose and GA showed similar results. The release of docetaxel from UV + glucose and GA crosslinked nanoparticles showed the same biphasic release. These data support the idea that crosslinking with a combination of UV and glucose can be a promising alternative method for production of docetaxel-loaded albumin nanoparticles with the advantage of omitting toxic GA.
Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-β receptor (1994)

Transforming growth factor-beta (TGF-beta) is thought to play a role in mesenchymal cell development and, specifically, in muscle differentiation, yet its precise role in the latter process remains unclear. TGF-beta has been shown to both inhibit and induce myoblast maturation in vitro, depending on the culture conditions. Whether the type I or type II TGF-beta receptor mediates the various TGF-beta effects on myogenesis is not known. In the present study, C2C12 myoblasts were transfected with an expression vector for a truncated type II TGF-beta receptor, which has been shown to act as a dominant negative inhibitor of type II receptor signaling. In contrast to the parental cells, the transfected clones did not efficiently form myotubes or induce expression of MyoD, myogenin and several other differentiation markers following incubation in low serum media. However, some muscle differentiation markers continued to be expressed in the transfected cells suggesting that at least two pathways are involved in muscle cell differentiation. These cells could still growth arrest in low serum media, showing that decreased proliferation can be dissociated from differentiation. Unlike several oncogenes known to block myogenic differentiation, expression of the truncated TGF-beta receptor did not result in myoblast transformation. Injection of the parental or the transfected C2C12 cells into the limb muscle of nude mice revealed quantitative and qualitative differences in their behavior, and suggested that myoblasts expressing the truncated TGF-beta receptor cannot fuse in vivo. Finally, retrovirus-mediated expression of MyoD in the transfected cells restored their ability to form myotubes in vitro, indicating that inhibition of myoblast differentiation by the truncated TGF-beta receptor may depend on decreased MyoD expression. We propose that TGF-beta signaling through the type II receptor is required for several distinct aspects of myogenic differentiation and that TGF-beta acts as a competence factor in this multistep process.
Elimination of dislocations in bulk GaAs crystals grown by liquid-phase electroepitaxy (1987)

The dislocation density in bulk GaAs crystals (up to 4 mm thick) grown by liquid-phase electroepitaxy (LPEE) is found to be significantly reduced (by as much as a factor of 20) relative to that in the substrate. This reduction takes place when the thickness of the growing crystal exceeds a critical value of 50–70 μm. It is accompanied by a formation of misfit dislocation arrays identified by transmission electron microscopy in the interface region between the substrate and grown crystals. These findings suggest that the reduction of the dislocation density is caused by a small but finite lattice mismatch between the growing epitaxial-quality crystal and the relatively inferior quality melt-grown substrate. Dislocations which propagate from the substrate into the LPEE crystal are forced by the misfit stress to move laterally forming misfit dislocations.
Preparation and characterization of copper(I) oxide nanoparticles dispersed in a polymer matrix (1998)

Nano-sized copper(i) oxide particles dispersed in nylon 11 thin films have been prepared by a thermal relaxation technique. The obtained composite films were characterized by XRD, HRTEM, XPS, AES and UV-VIS absorption spectroscopy. Upon heat treatment under air, metallic copper initially deposited on the nylon 11 surface penetrates into the bulk phase of the nylon 11 as Cu2O particles. The mean size of the Cu2O particles increased from 3.2 to 6.3nm in diameter upon increasing the amount of Cu deposition. UV-VIS spectroscopy revealed that the absorption increased from as low as 600nm with increasing the size and the concentration of the dispersed Cu2O particles.
Nitrogen Derivatives Of C-60 And C-70 - Interaction Of Fullerenes With Nitrogen In Gas-Phase (1992)

Mass spectrometric studies show that contact-arc vaporization of graphite in a partial atmosphere of N2 or NH3 yields nitrogenous products tentatively assigned to species such as C70N2, C59N6, C59N4 and C59N2 involving addition of or substitution by nitrogen along with the species due to C2 and C4 losses. Mass spectrometry and other techniques have been employed to identify products of the nucleophilic addition of aliphatic amines to C60 and C70 in solution phase.
Ca+2 mobilization and fibrinogen binding of platelets refractory to adenosine diphosphate stimulation. (1985)

The mechanism of adenosine diphosphate (ADP)-induced refractoriness was explored with iodine 125-labeled fibrinogen and the fluorescent Ca+2 indicator quin-2-tetraacetoxymethyl ester (quin-2). Gel-filtered platelets were rendered refractory by incubation (30 minutes, 22 degrees C) with either 10 mumol/L ADP alone or ADP and 125I-labeled fibrinogen. During the incubation period, platelets incubated with ADP alone showed an initial increase in quin-2 fluorescence, which gradually returned to baseline levels. Addition of 125I-fibrinogen to aliquots of the platelet suspension at various times during incubation showed that fibrinogen binding was normal after 1 minute but decreased to 50% in 30 minutes. According to Scatchard analysis, this decreased binding was attributed to decreased fibrinogen receptor availability, not decreased receptor affinity. Moreover, similar numbers of glycoprotein (GP) IIb-IIIa complexes remained available on platelets before and after incubation, as judged by the ability of a monoclonal antibody (10E5) directed against a complex specific epitope on GPIIb or IIIa to bind to control and refractory platelets. After incubation, platelets aggregated poorly in response to restimulation with ADP, although the amount of fibrinogen they bound (50% of normal) was sufficient to aggregate control platelets. Platelet restimulation with ADP was not accompanied by a rise in quin-2 fluorescence or exposure of additional fibrinogen receptors. Stimulation of platelets with thrombin, however, led to a rise in quin-2 fluorescence, exposure of additional fibrinogen receptors, and enhanced aggregation. Restimulation of platelets with epinephrine also increased fibrinogen receptor exposure and restored the ability of platelets to aggregate, but was accompanied by barely detectable changes in quin-2 fluorescence similar to those observed with epinephrine-treated control platelets. Platelets incubated for 30 minutes with ADP and 125I-fibrinogen also showed an initial rise in quin-2 fluorescence, which returned to baseline levels during incubation, but the amount of platelet-bound fibrinogen, normal at the onset, remained quantitatively unchanged. Much of this fibrinogen, however, no longer dissociated from platelets in the presence of ethylenediaminetetraacetic acid or apyrase, suggesting that a different type of platelet-fibrinogen interaction had developed. Restimulation of these platelets with ADP was not accompanied by increased fibrinogen binding or quin-2 fluorescence and failed to elicit significant platelet aggregation.(ABSTRACT TRUNCATED AT 400 WORDS)