gebhart/patrepeval huggingface dataset:
A Distributed Run-Time Environment for the Kalray MPPA®-256 Integrated Manycore Processor (2013)

The Kalray MPPA®-256 is a single-chip manycore processor that integrates 256 user cores and 32 system cores in 28 nm CMOS technology. These cores are distributed across 16 compute clusters of 16+1 cores, and 4 quad-core I/O subsystems. Each compute cluster and I/O subsystem owns a private address space, while communication and synchronization between them is ensured by data and control Networks-on-Chip (NoC). This processor targets embedded applications whose program- ming models fall within the following classes: Kahn Process Networks (KPN), as motivated by media processing; single program multiple data (SPMD), traditionally used for numerical kernels; and time-triggered control systems. We describe a run-time environment that supports these classes of programming models and their composition. This environment combines classic POSIX single-process multi-threaded execution inside the compute clusters and I/O subsystems, with a set of specific Inter-Process Communication (IPC) primitives that exploit the NoC architecture. We combine these primitives in order to provide the run-time support for the different target programming models. Interestingly enough, all these NoC-specific IPC primitives can be mapped to a subset of the classic synchronous and asynchronous POSIX file descriptor operations. This design thus extends the canonical ‘pipe-and-filters’ software component model, where POSIX processes are the atomic components, and IPC instances are the connectors.
Deracemization of Cyclic Allyl Esters (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDeracemization of Cyclic Allyl EstersBarry M. Trost and Michael G. OrganCite this: J. Am. Chem. Soc. 1994, 116, 22, 10320–10321Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/ja00101a070https://doi.org/10.1021/ja00101a070research-articleACS PublicationsRequest reuse permissionsArticle Views1502Altmetric-Citations104LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Voltage in-situ electrical metrology for test-to-failure BGA component shock margin assessment (2012)

As customers embrace new mobile market segments, electronic systems containing direct ball grid array (BGA) components will inevitably experience greater stresses resting from shock and drop events during their use. These events can result in BGA field failures especially when the product is exposed to solder joint or material excursions. Such issues could result in significant loss to the manufacturer in terms of line downtime or warranty returns. The current screening metrologies used for detection of BGA product solder joint failures are either time consuming, unreliable, or inefficient. Some of these methods can only be used with traditional daisy chain (DC) test packages and do not readily enable electrical monitoring of individual joints (or ball-level). To address the above problems, an innovative solution is required. This paper introduces a new cost-effective, efficient and reliable metrology also called voltage metrology to electrically detect ball-level failures in-situ on live product BGA components during the shock event. First, the metrology validation results collected on the product components are reviewed to demonstrate robustness. The benefits of this metrology are highlighted using drops-to-failure probability approach which is commonly used in the cell-phone industry. The data is used to compare the relative performance across different products, which is a common query from original design manufacturers (ODMs) and original equipment manufacturers (OEMs). This paper also presents examples showing how ball-level damage progression can help enable board design optimization through better printed circuit board (PCB) pad design and sacrificial pin definition. In addition, a case study is presented to demonstrate metrology effectiveness towards development of shock acceleration models. Finally, the paper shares necessary test vehicle (TV) design modifications to activate ball-level monitoring feature on traditional DC test coupons.
Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p (2007)

We have found an intriguing new association of the Hat1p-dependent histone acetyltransferase in addition to its previously known role in nuclear chromatin assembly (Hat1p/Hat2p-Hif1p). The participation of a distinct Hat1p/Hat2p sub-complex suggests a linkage of histone H4 modification with ORC-dependent DNA replication.
Diagnostic and Prognostic Potential of Extracellular Vesicles in Peripheral Blood (2014)

Overall, the use of EV analysis as a diagnostic and prognostic tool has prodigious clinical potential.
Narrowband Internet of Things: Evolutions, Technologies, and Open Issues (2017)

We are on the threshold of the explosive growth in the global Internet-of-Things (IoT) market. Comparing with the legacy human-centric applications, machine type communication scenarios exhibit totally different characteristics, such as low throughput, delay insensitivity, occasional transmission, and deep coverage. Meanwhile, it also requires the terminal devices to be cheap enough and sustain long battery life. These demands hasten the prosperity of low power wide area (LPWA) technologies. Narrowband IoT (NB-IoT) is the newest Long Term Evolution (LTE) specification ratified by the third generation partner project as one of the LPWA solutions to achieve the objectives of super coverage, low power, low cost, and massive connection. Working in the licensed frequency band, it is designed to reuse and coexist with the existing LTE cellular networks, which endows it with outstanding advantages in decreasing network installation cost and minimizing product time-to-market. In this backdrop, it has been extensively regarded as one of the most promising technologies toward the IoT landscape. However, as a new LTE standard, there are still a lot of challenges that need to overcome. This paper surveys its evolutions, technologies, and issues, spanning from performance analysis, design optimization, combination with other leading technologies, to implementation and application. The goal is to deliver a holistic understanding for the emerging wireless communication system, in helping to spur further research in accelerating the broad use of NB-IoT.
Breaking the Ban: Sports Gambling, Anti-Commandeering, and Lots and Lots of Money (2019)

While there are myriad factors impacting historical trends in gambling revenues across America, this Note will focus specifically on the legal treatment of sports gambling. In 1992, Congress passed the Professional and Amateur Sports Protection Act (“PASPA”), which banned sports gambling nationwide, with a few exceptions such as Las Vegas. Under PASPA, all states had a one-year grace period after the statute went into effect where they could legalize sports gambling within their state and escape PASPA’s pending ban. Although New Jersey failed to take advantage of this loophole during the grace period, state legislators attempted to legalize sports gambling twenty years later when voters approved an amendment to the state constitution in 2012. After a three-year legal battle with the National Collegiate Athletic Association (“NCAA”) and the National Football League, National Basketball Association, National Hockey League, and Major League Baseball (“the Leagues”), that progressed all the way to the Supreme Court of the United States, New Jersey ultimately lost its initial attempt to legalize sports gambling.
Expression of different chemokines by human osteosarcoma cells in response to tumor necrosis factor-alpha. (2000)

We investigated the expression of different chemokines in the surnatants and inside the cells of four human osteosarcoma cell lines. HOS, U-2 OS, MG63 and Saos-2 cells were cultured for 24, 48, 72 hours both in basal conditions and after stimulus with TNF alpha. Human stromal cells were used as control. IL-8 and MCP-1 are present in higher concentration in the surnatants in contrast to RANTES which is present primarily inside the cells. IL-8 and MCP-1 are not totally expressed by all the human osteosarcoma cell lines in unstimulated conditions, but became detectable after TNF alpha treatment. In general, this cytokine stimulated the production and release of the three chemokines.
Optimal spread spectrum sequences-constructed from Gold codes (2002)

This paper derives general results on the partial auto-correlation function of the optimal spreading sequences for asynchronous CDMA systems with respect to the minimization of the average error probability under the standard Gaussian approximation (SGA) condition without the assumption of stationary random processes on the spreading sequences. We construct a family of optimal spreading sequences from the existing Gold codes, which have the same number of codes as a set of Gold codes. An asynchronous CDMA system using such optimal spreading sequences allows 15% more users than when purely random binary sequences or Gold codes are employed. Moreover, the acquisition time performance of the proposed optimal spreading sequences is also shown to be better than that of Gold codes.
Role of CD38 and its ligand in the regulation of MHC-nonrestricted cytotoxic T cells. (1998)

Human CD38 is a type II transmembrane glycoprotein that regulates lymphocyte adhesion, proliferation, and cytokine production. The mAb Moon-1 recognizes a ligand for CD38 (CD38L) and specifically inhibits CD38-mediated cell adhesion. To analyze the role of CD38 and its ligand in MHC-nonrestricted T cell activation, we examined the effects of Moon-1 and the anti-CD38 mAb IB4 on the effector functions of the IL-2-dependent T cell line TALL-104 (CD3/TCR-alphabeta+, CD8+, CD56+) and of LAK cells (90% CD3+). TALL-104 cells were almost 100% reactive with both mAbs, whereas the reactivity of LAK cells for IB4 and Moon-1 ranged from 10 to 60% among different donors. From 78 to 94% of the cytotoxic CD8+/CD56+ LAK subset was CD38L+. Like mAb OKT3 (anti-CD3), and at variance with IB4, Moon-1 drastically enhanced the cytotoxicity of TALL-104 and CD8+ LAK cells against a resistant tumor target. Granule exocytosis did not appear to play a role in Moon-1-induced cytotoxicity. Moreover, neither IB4 nor Moon-1 induced [Ca2+]i mobilization in LAK and TALL-104 cells. Whereas stimulation of CD3 and CD38 resulted in a dramatic induction of cytokine (granulocyte-macrophage-CSF, IFN-gamma, TNF-alpha, and TNF-beta) release by both TALL-104 and LAK cells, ligation of CD38L was not followed by cytokine production in TALL-104 cells. Thus, cytotoxicity and cytokine release are independently regulated, at least in this system. These data demonstrate that CD38 and its ligand can regulate some T cell functions using signaling pathways distinct from those of CD3.
Effect of Pindolol on Stress-Related Disturbances of Musical Performance: Preliminary Communication<sup>1</sup> (1983)

The effect of 5 mg pindolol on stress-induced disturbances of performance were assessed in 30 professional musicians. An overall inverse relationship was found between anxiety and musical performance. Reduction in anxiety by administration of pindolol was associated with a subjective improvement in performance. A stress-related tachycardia and increase in systolic blood pressure were attenuated. Pindolol had no effect on peak flow measurements.
A quantitative approach to functional debugging (1997)

We introduce a novel cut-based debugging paradigm. It coordinates design emulation and simulation and enables fast transition from one to another. Emulation or functional implementation is used for fast application execution; simulation provides complete design observability and controllability. The implementation of the new debugging approach poses several CAD tasks. We formulate the optimization tasks and develop constraint-based heuristics to solve them. Effectiveness of the approach is demonstrated on a set of designs.
Functional Analysis of H-Ryk, an Atypical Member of the Receptor Tyrosine Kinase Family (1999)

H-Ryk is an atypical receptor tyrosine kinase which differs from other members of this family at a number of conserved residues in the activation and nucleotide binding domains. Using a chimeric receptor approach, we demonstrate that H-Ryk has impaired catalytic activity. Despite the receptor's inability to undergo autophosphorylation or phosphorylate substrates, we demonstrate that ligand stimulation of the chimeric receptor results in activation of the mitogen-activated protein kinase pathway. The ability to transduce signals is abolished by mutation of the invariant lysine (K334A) in subdomain II of H-Ryk. Further, by in vitro mutagenesis, we show that the amino acid substitutions in the activation domain of H-Ryk account for the loss of catalytic activity. In addition to the essential aspartate residue, either phenylalanine or glycine is required in the activation domain to maintain proper conformation of the catalytic domain and thus ensure receptor autophosphorylation. Homology modelling of the catalytic domain of H-Ryk provides a rationale for these findings. Thus, the signalling properties of H-Ryk are divergent from those of other classical receptor tyrosine kinases.
Frequency-selective electrokinetic enrichment of biomolecules in physiological media based on electrical double-layer polarization (2017)

Proteomic biomarkers of interest to the early diagnosis of diseases and infections are present at trace levels versus interfering species. Hence, their selective enrichment is needed within bio-assays for speeding binding kinetics with receptors and for reducing signal interferences. While DC fields can separate biomolecules based on their electrokinetic mobilities, they are unable to selectively enrich biomarkers versus interfering species, which may possess like-charges. We present the utilization of AC electrokinetics to enable frequency-selective enrichment of nanocolloidal biomolecules, based on the characteristic time constant for polarization of their electrical double-layer, since surface conduction in their ion cloud depends on colloidal size, shape and surface charge. In this manner, using DC-offset AC fields, differences in frequency dispersion for negative dielectrophoresis are balanced against electrophoresis in a nanoslit channel to enable the selective enrichment of prostate specific antigen (PSA) versus anti-mouse immunoglobulin antibodies that cause signal interferences to immunoassays. Through coupling enrichment to capture by receptors on graphene-modified surfaces, we demonstrate the elimination of false positives caused by anti-mouse immunoglobulin antibodies to the PSA immunoassay.
A novel broadband printed antenna element (2002)

A novel broadband printed antenna element, the printed counterpart of a conventional TV UHF panel antenna with very large bandwidth, has been studied. A design method and realization are presented in the paper. More than one octave measured bandwidth with VSWR less then 1.8 and directivity between 9.0 and 11.0 dBi has been achieved. Properties of the radiator as an array element have also been investigated.
<i>Microdochium tabacinum</i>, Confirmed as a Pathogen of Alfalfa in Gansu Province, China (2014)

A crown and root rot complex was detected in the alfalfa (Medicago sativa 'Longdong') fields of Huanxian County. The symptoms of the diseased plants were characterized, and 11 fungal species were obtained from the roots. These fungi included isolates that resembled the genus Microdochium. An isolate of this type, designated MP313, was proven to infect alfalfa, fulfilling Koch's postulates. Isolate MP313 was examined by microscopy and the morphological characteristics indicated that it was similar to members of the genus Microdochium. Sequence analyses of the 28S large subunit as well as the internal transcribed spacer (ITS) region of the ribosomal DNA (rDNA) of MP313 revealed 98 to 100% similarity to the corresponding regions of M. tabacinum. A polymerase chain reaction assay based on the ITS region of the rDNA was developed to amplify a 304-bp fragment from DNA concentrations as low as 20 fg/μl, which was sensitive enough to detect isolate MP313 in diseased root samples. Taken together, these results confirmed that M. tabacinum was one of a complex of fungi associated with crown and root rot in the alfalfa samples collected in Gansu Province. This is the first report of M. tabacinum being a pathogen of alfalfa in China.
Structure and stability of <i>Ricinus communis</i> haemagglutinin (1986)

The molecular properties of the haemagglutinin of Ricinus communis (RCA I or RCA 120) were evaluated by analytical ultracentrifugation, light-scattering, c.d. and fluorescence. The native molecule had a fairly expanded structure (f/f0 = 1.43) and dissociated into two subunits of equal size in 6 M-guanidinium chloride. This native structure was stable in alkali (up to pH 11) and resistant to thermal denaturation at neutrality. A pH-triggered change in the haemagglutinin conformation was observed and characterized by analytical ultracentrifugation, c.d. and fluorescence between pH 7 and 4.5, the range in which its affinity for galactosides decreased [Yamasaki, Absar & Funatsu (1985) Biochim, Biophys. Acta 828, 155-161]. These results are discussed in relation to those reported in the literature for other lectins and more especially ricin, for which a pH-dependent conformation transition has been observed in the same range of low pH.
Ensemble Computing (2001)

The technology space that includes ubiquitous computing, information appliances, and pervasive and situated systems is the subject of intense interest among the research community. In this article, we examine some of the principles implicit in this space and introduce the idea of "ensemble computing" to describe technologies that extend this space.
A cDNA Encoding a Rat Mitochondrial Cytochrome P450 Catalyzing Both the 26-Hydroxylation of Cholesterol and 25-Hydroxylation of Vitamin D <sub>3</sub> : Gonadotropic Regulation of the Cognate mRNA in Ovaries (1990)

A cDNA expression library prepared from rat liver RNA was screened with a polyclonal antibody specific for mitochondrial vitamin D3 25-hydroxylase and a cDNA for rabbit liver mitochondrial cytochrome P450c26 (CYP 26), yielding cDNA clones with identical sequences. The deduced amino acid sequence derived from a 1.9-kb full-length cDNA was 73% identical to that of rabbit cytochrome P450c26. A monoclonal antibody was used to demonstrate that the product of the 1.9-kb cDNA clone was targeted to the mitochondrial compartment when expressed in COS cells. Mitochondrial membranes containing the expressed protein showed both vitamin D3 25-hydroxylase and cholesterol 26-hydroxylase activities when reconstituted with ferredoxin reductase and ferredoxin, demonstrating that the same P450, designated as P450c26/25, can catalyze both reactions. Northern blot analysis revealed that the P450c26/25 cDNA hybridizes with a 2.4-kb RNA from rat liver and unstimulated ovaries. Treatment of rats with pregnant mare's serum gonadotropin resulted in a fivefold increase in the 2.4-kb mRNA as well as the appearance of a 2.1-kb mRNA species in the ovaries. Our findings document the presence of a regulated bifunctional mitochondrial cytochrome P450 capable of catalyzing the 25-hydroxylation of vitamin D3 and the 26-hydroxylation of cholesterol.
ChemInform Abstract: Asymmetric Synthesis of α‐Substituted o‐Methoxybenzyl Alcohols via Stereoselective Additions to Kinetically Resolved o‐Anisaldehyde(tricarbonyl)chromium. (1989)

Abstract Resolution of the aldehyde (±)‐(I) is achieved by reaction with valinol (II) followed by selective hydrolysis of the resulting diastereomeric imines.
Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery (2017)

Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have been largely unsuccessful, a consequence of an inadequate understanding of the complexity and heterogeneity of the innate immune response. Moreover, the conventional drug development pipeline is time consuming and expensive and the low success rates associated with cell-based screens underline the need for whole organism screening strategies, especially for complex pathological processes. Here, we established an LPS-induced zebrafish endotoxemia model, which exhibits the major hallmarks of human sepsis including, edema and tissue/organ damage, increased vascular permeability and vascular leakage accompanied by an altered expression of cellular junction proteins, increased cytokine expression, immune cell activation and ROS production, reduced circulation and increased platelet aggregation. We tested the suitability of the model for phenotype-based drug screening using three primary readouts: mortality, vascular leakage, and ROS production. Preliminary screening identified fasudil, a drug known to protect against vascular leakage in murine models, as a lead hit thereby validating the utility of our model for sepsis drug screens. This zebrafish sepsis model has the potential to rapidly analyze sepsis associated pathologies and cellular processes in the whole organism, as well as to screen and validate large numbers of compounds that can modify sepsis pathology in <i>vivo</i>.
Visual recognition of multi-agent action (1999)

Thesis (Ph.D.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 1999.
Interleaved FDMA: equalization and coded performance in mobile radio applications (2003)

"Interleaved frequency-division multiple-access" (IFDMA) has previously been introduced as a new spread-spectrum multiple-access scheme for mobile communications. In this paper, performance results for uncoded and coded mobile radio transmission taking into account different equalization techniques are presented. As a result, equalization reduces the effects of intersymbol interference significantly. Uncoded IFDMA applying optimum equalization performs even better than uncoded multicarrier code-division multiple-access applying maximum likelihood multi-user detection. Moreover, in the case of coded IFDMA transmission coding gains up to 6.8 dB at a bit-error-rate of 10/sup -4/ are achieved using a standard convolutional code.