gebhart/patrepeval huggingface dataset:
Abstract 2832: Development of AGS-22M6E, a novel antibody drug conjugate (ADC) targeting Nectin-4 for the treatment of solid tumors (2011)

Abstract Nectin-4 is a type I transmembrane antigen identified by Agensys to be highly expressed at the RNA level in a significant number of bladder and breast cancer specimens. Analysis of protein expression carried out in an extensive panel of tumor specimens by immunohistochemistry confirmed strong to moderate expression levels of Nectin-4 in bladder, breast and pancreatic cancers (40-60%). A subset of lung and ovarian cancers (up to 30%) also showed significant expression levels of this protein. We have generated an antibody-drug conjugate (ADC) targeting Nectin-4, AGS-22M6E. The highly potent microtubule disrupting drug monomethyl auristatin E (MMAE) was conjugated via valine-citrulline cleavable linker to a fully human IgG1k antibody specific for Nectin-4. AGS-22M6E was characterized for binding affinity, species crossreactivity and cytotoxicity in vitro. AGS-22M6E binds to cell surface Nectin-4 with high affinity and crossreacts with Nectin-4 orthologs of cynomolgus monkey, rat and murine origin. Upon binding to its target on the cell surface AGS-22M6E is internalized and induces cell death in vitro in a dose dependent manner. In vivo efficacy of AGS-22M6E was tested in SCID mice on xenograft models of breast, bladder, pancreatic and lung cancers in subcutaneous and orthotopic modalities. Treatment of well established tumor xenografts with the ADC resulted in significant growth inhibition or complete eradication of tumors in various models covering multiple cancer indications. Pharmacokinetics of AGS-22M6E in non-tumor bearing mice was also evaluated and will be discussed. Overall, these data validate AGS-22M6E as an attractive therapeutic drug candidate for multiple solid tumor indications and support further clinical investigation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2832. doi:10.1158/1538-7445.AM2011-2832
Improved intrinsic resolution: does it make a difference? Concise communication. (1984)

The purpose of this study was to determine what effect further improvement in an Anger camera's intrinsic resolution has on lesion detection. We studied 52 patients undergoing bone imaging and 58 undergoing liver imaging. All patients had images performed in rapid sequence on ZLC -75 and ZLC -37 Anger cameras, both by Siemens. The two imaging systems are virtually identical except for the number of photomultiplier tubes and crystal thickness; these resulted in differences in intrinsic resolution ( ZLC -75 less than 3.8 mm FWHM at 140 keV, ZLC -37 less than 4.9 mm) and sensitivity ( ZLC -75 approximately 0.91 of ZLC -37 at 140 keV). Observer performance, measured by ROC curves, for detection of abnormalities was virtually identical with the two instruments. Subjectively, there was a trend toward preference of the ZLC -75 images, but this was not associated with any significant improvement in lesion detectability even in the subgroup in which a preference for one or the other instrument was noted.
Low-Density Lipoprotein Reconstituted by Pyropheophorbide Cholesteryl Oleate as Target-Specific Photosensitizer (2002)

To target tumors overexpressing low-density lipoprotein receptors (LDLr), a pyropheophorbide cholesterol oleate conjugate was synthesized and successfully reconstituted into the low-density lipoprotein (LDL) lipid core. Laser scanning confocal microscopy studies demonstrated that this photosensitizer-reconstituted LDL can be internalized via LDLr by human hepatoblastoma G(2) (HepG(2)) tumor cells.
Dinuclear rhodium and iridium complexes of dicarboxyimidazolates; crystal structure of [NBu<sub>4</sub>][(cod)Rh(dcbi)Rh(cod)]·2Pr<sup>i</sup>OH (1987)

Dinuclear complexes of rhodium and iridium with 4,5-dicarboxyimidazole (H3dcbi) and 4,5-dicarboxy-2-methylimidazole (H3dcbmi) are reported. In each case, the bridging carboxyimidazole ligand binds as the trianion. The auxiliary ligands are cycle-octa-1,5-diene(cod), carbon monoxide, and triphenylphosphine. The CO complexes, such as [NR4][(OC)2Ir(dcbi)Ir(CO)2] which contains a planar dinuclear anion, exhibit strong colours which are caused by intermolecular stacking interactions and which are modulated by the counter cation. The X-ray crystal structure of [NBu4][(cod)Rh(dcbi)Rh(cod)]·2PriOH is described.
<i>Erratum for Ann. N.Y. Acad. Sci. 1108: 505–514</i> (2008)

Annals of the New York Academy of SciencesVolume 1126, Issue 1 p. 335-335 Free Access Erratum for Ann. N.Y. Acad. Sci. 1108: 505–514 Autoimmunity, Part D: Autoimmune Disease, Annus Mirabilis. Yehuda Shoenfeld and M. Eric Gershwin, Eds. This article corrects the following: Pregnancies Complicated with Antiphospholipid Syndrome: The Pathogenic Mechanism of Antiphospholipid Antibodies NICOLETTA DI SIMONE, MERONI PIER LUIGI, D'ASTA MARCO, DI NICUOLO FIORELLA, D'IPPOLITO SILVIA, D'ALESSIO MARIA CLARA, CARUSO ALESSANDRO, Volume 1108Issue 1Annals of the New York Academy of Sciences pages: 505-514 First Published online: August 29, 2007 First published: 23 April 2008 https://doi.org/10.1196/annals.1433.070AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat In the chapter cited in Reference 1, the authors' last names (except for Nicoletta Di Simone) on page 505 were inadvertently placed first. They should have read as follows: NICOLETTA DI SIMONE,a PIER LUIGI MERONI,b MARCO D'ASTA,a FIORELLA DI NICUOLO,a SILVIA D'IPPOLITO,a MARIA CLARA D'ALESSIO,a AND ALESSANDRO CARUSOa We apologize for this error. Reference 1 Di Simone, N. et al. 2007. Pregnancies complicated with antiphospholipid syndrome: the pathogenic mechanism of antiphospholipid antibodies. A review of the literature. Ann. N.Y. Acad. Sci. 1108: 505– 514. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Volume1126, Issue1The Maillard Reaction Recent Advances in Food and Biomedical SciencesApril 2008Pages 335-335 ReferencesRelatedInformation
Mass Transport Processes and their Roles in the Formation, Structure, and Evolution of Stars and Stellar Systems (2009)

Kenneth G. Carpenter (NASA-GSFC), Margarita Karovska (CfA), Carolus J. Schrijver (LMATC), Carol A. Grady (Eureka Scientific), Ronald J. Allen (STScI), Alexander Brown (UColo), Steven R. Cranmer (CfA), Andrea K. Dupree (CfA), Nancy R. Evans (CfA), Edward F. Guinan (Villanova U.), Graham Harper (UColo), Antoine Labeyrie (College de France), Jeffrey Linsky (UColo), Geraldine J. Peters (USC), Aki Roberge (NASA-GSFC), Steven H. Saar (CfA), George Sonneborn (NASA-GSFC), and Frederick M. Walter (SUNY)
On Spherical vs. Plane Wave Modeling of Line-of-Sight MIMO Channels. (2006)

In this paper we consider pure line-of-sight multiple-input multiple-output channels employing uniform linear antenna arrays. We investigate the influence of exact spherical wave propagation modeling versus approximate plane wave propagation modeling on the properties of the MIMO channel matrix. When transmission distance increases, the properties of the singular values of the MIMO channel matrix given by the spherical wave model approach the properties given by the simpler plane wave model. We investigate this transition between the two channel models, which results in a new tool giving us analytical expressions describing when spherical wave modeling is necessary and when plane wave modeling gives sufficient modeling accuracy. The parameters of interest are the transmission distance, the frequency, the array orientation, and the array size. The tool introduced is general, in the sense that it supports different performance measures when deciding on the transition between the two models. As an example, we investigate underestimation of the mutual information in this paper. The results show that the spherical wave model should be applied e.g. in some practical WLAN scenarios where plane wave modeling is commonly applied today.
Estimation of Force and Extensor Moment Contributions of the Disc and Ligaments at L4-L5 (1988)

An anatomic-mathematical representation of the individual ligaments and disc at L4-L5 was used in a model to examine their role in joint behavior. Geometry of the anatomic components was obtained from cadaveric dissection and the anatomic literature; mechanical properties were obtained from various literature sources. Resistance to flexion of the L4-L5 joint was simulated using various ligament cross-sectional areas, and combined loading modes of compression coupled with bending in an attempt to understand physiologic conditions that may occur during activities such as lifting. Results suggest that the interspinous ligament sustains the greatest stress during flexion at L4-L5, is the dominant component in resistance to flexion, and also creates large shear components that must be resisted by the facet complex. Simulated compressive loads of 6300 N were noted to allow an additional 2 degrees of flexion at the joint.
Use of a Fiber‐Containing Enteral Formulation in an Aids Patient (1989)

The value of aggressive nutritional support in the patient with AIDS requires further study. As medical treatment modalities become more sophisticated, the etiology of complications that are associated with AIDS are more clearly understood and can be more effectively treated. Survival rates of greater than one and one-half years after an episode of pneumocystis are now more common. As clinicians become more familiar with AIDS and as new medical treatments are discovered, there is reason to believe that a gradual improvement in survival and quality of life will continue. Therefore, further research is needed to determine the point at which nutritional therapy is truly beneficial in the AIDS population.
Lightweight searchable screen video recording (2012)

Command logging of maintenance and operation activities of modern computer systems has become an integral component of customer and audit requirements. In recent years, this logging has usually been achieved via desktop video recording. However, the conventional approach of video recording requires high computation overhead, high network bandwidth, and a large storage size. Searching through video files is also a challenge. In this paper, we present a lossy, but text text-preserving, compression scheme that meets these challenges by creating a sparse bitonal image suitable for optical character recognition (OCR). Using our system for auditing, the bitonal image gets stored on a server. Due to the mechanism's text-preserving compression, we can apply OCR off-line to create annotations of each video frame, making the output searchable. Compared to state-of-the-art compression of raw video, our approach can reduce file size by 50-80%, while using CPU and memory resources similar to other methods.
Biomimetic Hydroxylation of Nonactivated CH<sub>2</sub> Groups with Copper Complexes and Molecular Oxygen (2003)

Copper(I) complexes with steroidal ligands (see formula) undergo regio- and stereoselective γ-hydroxylation in the 12β-position of the steroid in the presence of molecular oxygen. After reduction a 17β,12β-amino alcohol is obtained. Under hydrolytic conditions a 12β-hydroxy-17-ketone can be isolated.
Screening for childhood strabismus by primary care physicians. (1998)

Primary care physicians are essential to early detection of strabismus and amblyopia. Early detection can help minimize visual dysfunction, allow for normal development of binocular vision and depth perception, and prevent psychosocial dysfunction.
A versatile timing microsystem based on wafer-level packaged XTAL/BAW resonators with sub-µW RTC mode and programmable HF clocks (2013)

Over recent years the several decades long quartz-dominated timing industry has been continuously challenged by the introduction of new products or demonstration of prototypes based on MEMS resonators [1-4]. The poor intrinsic stability of such devices has led to the development of very high performance temperature sensors to reach TCXO-level frequency stability [5]. One of the true advantages of the technology is the fact that well-proven semiconductor manufacturing technologies amenable for high volume production can be leveraged to produce wafer-level encapsulated low-cost components. This paper explores how XTAL resonators could benefit from similar wafer level, vacuum sealing packaging technologies with the demonstration of a generic versatile timing module.
ChemInform Abstract: SYNTHESIS AND REACTIVITY OF DIHYDROTRIAZINES AND DIHYDROTRIAZOLOTRIAZINES (1979)

Abstract Die Dihydro‐triazine (I) werden nach bekannten Verfahren hergestellt.
Dose responses of cerebral arteries of the dog, rabbit, and man to human hemoglobin in vitro (1980)

Dose responses in vitro of the basilar arteries of the dog, rabbit, and man to human hemoglobin and reported. For each species, the response occurred over a range of 10(-9)M to greater than 10(-5)M hemoglobin. When compared to a maximum serotonin contraction, the relative constriction induced by 10(-5)M hemoglobin was greater in the rabbit than in the dog, which in turn was greater than in man. The comparatively weak response of the human arteries is probably attributable to postmortem changes.
Using Natural Language Tool to Assist VPRG Automated Extraction from Textual Vulnerability Description (2011)

This paper presents an application of Natural Language Tool (NLT) to support the VPRG extraction of text based vulnerability description. The NLT is used to analyze the text-based vulnerability descriptions to retrieve vulnerability properties and evaluate their relationships. Then, a graph based VPRG model that describes the vulnerability can be established. Finally, with fine-tuning from domain expertise, the VPRG model can be useful for analyzing and evaluating web-based vulnerabilities. This approach is proposed to support automatic VPRG extraction from several online database resources as well as vulnerability analysis.
A cellular pulse switching architecture for binary event sensing (2012)

This paper presents a novel energy-efficient pulse switching protocol for ultra-light-weight cellular sensor network applications. The key idea is to abstract a single pulse, as opposed to multi-bit packets, as the information exchange mechanism. Pulse switching is shown to be sufficient for event monitoring applications with binary sensing in terms of cellular localization. Event monitoring with conventional packet transport can be prohibitively energy-inefficient due to the communication, processing, and buffering overheads of the large number of bits within a packet's data, header, and preambles. The paper presents a joint MAC and Routing architecture for pulse switching with novel cellular event localization. Through simulation experiments, it is shown that pulse switching can be an effective means for event based networking, which can potentially replace packet transport when the information to be transported is binary in nature.
Gold and silver nanoparticle monomers are non-SERS-active: a negative experimental study with silica-encapsulated Raman-reporter-coated metal colloids (2014)

Noble metal nanoparticles (NPs) are the most commonly employed plasmonic substrates in surface-enhanced Raman scattering (SERS) experiments. Computer simulations show that monomers of Ag and Au nanocrystals ("spherical" NPs) do not exhibit a notable plasmonic enhancement, i.e., they are essentially non-SERS-active. However, in experiments, SERS enhanced by spherical NP colloids has been frequently reported. This implies that the monomers do not have strong SERS activity, but detectable enhancement should more or less be there. Because of the gap between theory and practice, it is important to demonstrate experimentally how SERS-active the metal colloid actually is and, in case a SERS signal is observed, where it originates from. In particular the aggregation of the colloid, induced by high centrifugal forces in washing steps or due to a harsh ionic environment of the suspension medium, should be controlled since it is the very high SERS activity of NP clusters which dominates the overall SERS signal of the colloid. We report here the experimental evaluation of the SERS activity of 80 nm Au and Ag NP monomers. Instead of showing fancy nanostructures and super SERS enhancement, we present the method on how to obtain negative experimental data. In this approach, no SERS signal was obtained from the colloid with a Raman reporter on the metal surface when the NPs were encapsulated carefully within a thick silica shell. Without silica encapsulation, if a very low centrifugation speed is used for the washing steps, only a negligible SERS signal can be detected even at very high NP concentrations. In contrast, strong SERS signals can be detected when the NPs are suspended in acidic solutions. These results indicate that Au and Ag NP monomers essentially exhibit no SERS activity of practical relevance.
Disintegration of Urinary Calculi by Laser Beam: Drilling Experiment in Extracted Urinary Stones (1979)

Disintegration of urinary calculi was attempted by the use of laser beam. As a first step, drilling of extracted urinary stones was attempted using a continuous wave CO2 laser and a pulse ruby laser. Stones were drilled easily by either laser beam. The power around 10 W of continuous CO2 laser beam was sufficient to drill through the stone.
MAR-SI, Martin Surface Insulation (1973)

The development of an alumina/silicate based composite material for space shuttle reusable surface insulation is reported. Physical property determinations, environmental testing, design analysis, and projected costs for a thermal protection system are outlined.
A Next-Generation Secure Cloud-Based Deep Learning License Plate Recognition for Smart Cities (2016)

License Plate Recognition System (LPRS) plays a vital role in smart city initiatives such as traffic control, smart parking, toll management and security. In this article, a cloud-based LPRS is addressed in the context of efficiency where accuracy and speed of processing plays a critical role towards its success. Signature-based features technique as a deep convolutional neural network in a cloud platform is proposed for plate localization, character detection and segmentation. Extracting significant features makes the LPRS to adequately recognize the license plate in a challenging situation such as i) congested traffic with multiple plates in the image ii) plate orientation towards brightness, iii) extra information on the plate, iv) distortion due to wear and tear and v) distortion about captured images in bad weather like as hazy images. Furthermore, the deep learning algorithm computed using bare-metal cloud servers with kernels optimized for NVIDIA GPUs, which speed up the training phase of the CNN LPDS algorithm. The experiments and results show the superiority of the performance in both recall and precision and accuracy in comparison with traditional LP detecting systems.
Interleukin-6, tumour necrosis factor α and interleukin-1β in patients with renal cell carcinoma (2002)

As regulators of malignant cell behaviour and communication with stroma, cytokines have proved useful in understanding cancer biology and developing novel therapies. In renal cell carcinoma, patients with inflammatory reactions are known to have poor prognosis. In order to elucidate the relation between renal cell carcinoma and the host, serum levels of inflammatory cytokines, interleukin-6, tumour necrosis factor alpha, interleukin-1beta, were measured. One hundred and twenty-two patients with renal cell carcinoma and 21 healthy control subjects were studied, and serum cytokine levels were measured using a highly sensitive ELISA kit. As a result, in the control group, interleukin-6, tumour necrosis factor alpha and interleukin-1beta levels were 1.79+/-2.03, 2.74+/-0.94 and 0.16+/-0.17 pg ml(-1), respectively. In the renal cell carcinoma patients, they were 8.91+/-13.12, 8.44+/-4.15 and 0.53+/-0.57 pg ml(-1), respectively, and significantly higher. In the comparison of stage, interleukin-6 level was significantly higher in the stage IV group compared to the other stage groups including the control group, while tumour necrosis factor alpha level was significantly higher in each stage group compared to the control group. As for grade, interleukin-6 level was significantly higher in the grade 3 group compared to the control, grade 1 and grade 2 groups, while tumour necrosis factor alpha level was significantly higher in each grade group compared to the control group. All cytokines had a positive correlation with tumour size. In regard to the correlation with CRP, all cytokines had a positive correlation with CRP, while interleukin-6 had a particularly strong correlation. In conclusion, interleukin-6 may be one of the factors for the poor prognosis of patients with renal cell carcinoma. In addition, tumour necrosis factor alpha may be useful in the early diagnosis of renal cell carcinoma and post-operative follow-up.
Acoustical properties of porous materials. Modifications of Delany-Bazley models. (1990)

The characteristic impedance and propagation constant of porous materials are discussed from a viewpoint of physical realizability, and new regression models based on experimental data by Delany and Bazley are derived. Modifications from their original models are so made that the impedance function satisfies the positive-real property and that the propagation constant written in terms of complex variables becomes a regular function in the right half-plane. The new models are shown to be useful for the prediction of acoustical behavior of porous materials, especially in the double-layer case, even outside the frequency range of validity of the original models.
Vanishing of superconductivity at a transition from itinerant-electron to small-polaron conduction in nominal Bi4−<i>x</i>Pb<i>x</i>(Sr3Ca)Ca2−<i>x</i>Y<i>x</i>Cu4O16 (1988)

Lead was found to substitute for bismuth on cosubstitution of yttrium for calcium in nominal Bi4(Sr3Ca)Ca2Cu4O16. Variations with x in the lattice parameters, the oxidation parameter determined by iodometric titration, and the temperature dependence of resistance have revealed a correlation of the variation of Tc and c parameter versus x with a metal-to-semiconductor transition. It is argued that this correlation manifests a transition from itinerant-electron to small-polaron conduction. This conclusion is related to the observed shifts in c-axis oxygen that appear to be associated with a transition from antiferromagnetic semiconductor to a superconductor in other copper-oxide systems.