gebhart/patrepeval huggingface dataset:
Endothelins. (1990)

The endothelins (ETs) are a family of newly discovered peptides with potent vasoconstrictor properties. They were first discovered in cultured endothelial cells but ET expression has since been found in many other tissues such as brain and kidney. They are peptides with 21 amino acids formed by hydrolytic cleavage of a larger peptide, big ET. Release of ETs from cultured endothelial cells is modulated by a variety of chemical and physical stimuli and as no storage sites have been identified it is suggested that endothelin release is regulated at the level of transcription or translation. Both big ET and ET-1 are found circulating in the blood. The levels are elevated in shock, myocardial infarction and kidney failure indicative of enhanced formation in these diseases. The literature now abounds with reports on actions of the ETs in vitro and in vivo. The vasoconstrictor properties are powerful and long-lasting. Several studies also show a mitogenic effect, indicating a possible trophic role. It is likely that in the next few years the development of inhibitors of endothelin synthesis and/or action will be of importance in unravelling the role of the ETs.
Synthesis of 3‐substituted‐2‐cyanoacrylates: Their evaluation as cross‐linkers in cyanoacrylate adhesive compositions (1993)

Abstract Alkyl 2‐cyano‐2,4‐pentadienoates and alkyl 2‐cyano‐2,4‐hexadienoates were synthesized and characterized by spectroscopic methods. These were then evaluated as cross‐linkers in 2‐cyanoacrylate adhesive compositions to improve the heat stability of their adhesive bonds between various metal surfaces. © 1993 John Wiley & Sons, Inc.
[The formation of monoclonal antibody to the cell membrane region of the stratum corneum and keratohyaline granules of newborn rat]. (1989)

We have developed a monoclonal antibody to the cell membrane region of the stratum corneum and keratohyalin granules using rat hematoxylin stainable proteins as an antigen. These hematoxylin stainable proteins were partially purified utilizing preparative isoelectric focusing from 50 mM Tris-HCl buffer soluble fraction of newborn rat epidermis. The developed monoclonal antibody located in both sites of the cell membrane region of the stratum corneum and keratohyalin granules (Ted-R-3). In an immunoblotting study using two-dimensional electrophoresis, a single protein which had a molecular weight of 55 kd reacted. The amino acid analysis of the affinity purified antigen showed that glycine, serine and glutamic acid residues comprised 20.4%, 18% and 12.6%, respectively. However, histidine and cystine residues comprised only 2.8% and 0.12%, respectively.
Via Diode in Cu Backend Process for 3D Cross-Point RRAM Arrays (2014)

In this paper, a fully logic compatible via diode is developed for high-density resistive random access memory (RRAM) array applications. This novel via diode is realized by advanced 28nm CMOS technology with Cu damascene via. The device is stacked between a top Cu via and a bottom Cu metal with a composite layer of TaN/TaON based dielectric film. An asymmetric current-voltage characteristic in this MIM structure provides a forward/reverse current ratio up to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> . In a cross-point RRAM array, the suppression of sneak current path by incorporating this via diode enables array size to be greatly expended. Via diode provides an excellent solution for high-density embedded nonvolatile memory applications in the nano-scale CMOS technology.
Covalently closed circular DNAs of murine type C retrovirus: depressed formation in cells treated with cycloheximide early after infection (1980)

Formation of viral closed circular supercoiled DNA duplexes and production of progeny virus were both inhibited in cultured mouse cells treated with cycloheximide in the first 4 h of type C retrovirus infection. With different doses of cycloheximide to cause different degrees of inhibition, the number of viral supercoiled DNA duplexes detected in the cells at 11 h showed an apparent correlation with the amount of progeny virus produced in the 12- to 22-h period of infection. A slight accumulation of the full-genome linear duplex and an open circular duplex of viral DNA intermediate was observed in the cycloheximide-treated cells. Cycloheximide given to the cells during the time of conversion of viral DNA from linear to supercoiled duplex forms (6 to 11 h after virus inoculation) did not inhibit the conversion. These kinetic data suggest that a cycloheximide-sensitive metabolic process, probably early viral protein synthesis, is required for retrovirus replication and supercoiled viral DNA formation in the cell.
Hydrogen-Bonded Liquid Crystalline Materials: Supramolecular Polymeric Assembly and the Induction of Dynamic Function (2001)

Liquid crystals are molecular materials that combine anisotropy with dynamic nature. Recently, the use of hydrogen bonding for the design of functional liquid crystalline materials has been shown to be a versatile approach toward the control of simple molecularly assembled structures and the induction of dynamic function. A variety of hydrogen-bonded liquid crystals has been prepared by molecular self-assembly processes via hydrogen bond formation. Rod-like and disk-like low-molecular weight complexes and polymers with side-chain, main-chain, network, and guest-host structures have been built by the complexation of complimentary and identical hydrogen-bonded molecules. These materials consist of closed-type hydrogen bondings. Another type of hydrogen-bonded liquid crystals consists of open-type hydrogen bonding. In this case, the introduction of hydrogen bonding moieties, such as hydroxyl groups, induces microphase segregation leading to liquid crystalline molecular order. Moreover, liquid crystalline physical gels have been prepared by the molecular aggregation of hydrogen-bonded molecules in non-hydrogen-bonded liquid crystals. They show significant electrooptical properties. An anisotropic gel is a new type of anisotropic materials forming heterogeneous structures.
Concepts, History, Principles, and Application of Germplasm Cryopreservation Technology (2020)

Germplasm are living genetic resources that can serve as bearers of heredity, and include germ cells and their precursors, plant seeds and pollen, animal sperm, oocytes, embryos, and larvae. Cryopreservation refers to the preservation of biological materials at extremely low temperatures, typically using solid carbon dioxide at -80°C or liquid nitrogen at -196°C for freezing, and cryogenic storage in perpetuity. Germplasm cryopreservation is an important technology applied for medical treatment, maintenance of biological diversity, preservation of valuable genetic resources, assistance of breeding programs, and conservation of imperiled species. This extension publication is intended to introduce the basic concepts, history, principles, and applications of germplasm cryopreservation technology.
The Development of an Instrument to Evaluate Distance Education Courses Using Student Attitudes (2005)

Abstract This study sought to adapt and test a methodological framework designed to produce a course evaluation that addresses the unique aspects of distance education while maintaining consistency with current evaluation instruments commonly used to evaluate an institution's on-campus courses. Using the four-step process adapted from Biner (1993), twenty items were identified for inclusion in the instrument. The authors concluded that the four-step process yielded an instrument for the evaluation of distance education courses that provides both functionality and flexibility to be used across a variety of courses.
Nucleolin-Mediated Cellular Trafficking of DNA Nanoparticle Is Lipid Raft and Microtubule Dependent and Can Be Modulated by Glucocorticoid (2010)

DNA nanoparticles (DNPs) are nonviral gene transfer vectors with excellent in vivo potential. Previously, we reported that cell surface nucleolin directly binds DNPs, and functions as an important receptor for DNPs. However, the fate of the nucleolin-DNP complex following cellular uptake remains elusive. In this study, we examined the role of lipid rafts in the uptake of DNPs, and found that both nucleolin and DNPs are recovered from the low-density raft fractions of the sucrose gradient. Furthermore, nucleolin colocalizes with, and coimmunoprecipitates with a raft protein, flotillin. Disruption of lipid rafts by depleting membrane cholesterol significantly inhibited DNP transfection, while inhibition of other endocytic pathways had little effect. Following the uptake, the nuclear import of the DNPs required microtubules but not F-actin. By coimmunoprecipitation in conjunction with tandem mass spectrometry, we identified glucocorticoid receptor (GCR) as a nucleolin-associated protein, and confirmed this result by western blot. Cortisone or dexamethasone increased nucleolin's association with GCR, and transfection by DNPs. Finally, we detected the expression of nucleolin on the surface of airway epithelia in vivo. Taken together, our findings shed light on important determinants of DNP trafficking in cells and support the notion that nucleolin is a good target for nonviral gene delivery.
Ascorbic Acid Reduces Blood Pressure and Arterial Stiffness in Type 2 Diabetes (2002)

Experimental evidence suggests that acute parenteral administration of high-dose ascorbic acid has beneficial vascular effects in type 2 diabetes. We studied the hemodynamic effects of chronic oral supplementation in this condition. Thirty patients, 45 to 70 years of age, with type 2 diabetes, were randomly assigned in a double-blind manner to receive 500 mg ascorbic acid daily by mouth or placebo. Patients were studied at baseline and after 4 weeks of assigned treatment. The central aortic augmentation index (AgIx) and the time to wave reflection (Tr) were derived from radial artery pulse wave analysis data. AgIx and Tr were used as measures of systemic arterial stiffness and aortic stiffness, respectively. Ascorbic acid decreased brachial systolic blood pressure from 142.1+/-12.6 (SD) to 132.3+/-12.1 mm Hg (difference [95% CI] 9.9 [4.7, 15.0]; P<0.01), brachial diastolic pressure from 83.9+/-4.8 to 79.5+/-6.0 mm Hg (4.4 [1.8, 7.0]; P<0.01), and AgIx from 26.8+/-5.5% to 22.5+/-6.8% (4.3 [1.5, 7.1]; P<0.01). Tr increased from 137.1+/-12.6 to 143.4+/-9.2 ms (-6.3 [-10.1, -2.5]; P<0.01). Placebo had no hemodynamic effects, and this difference between treatments was significant (P<0.01 for blood pressure and Tr, P=0.03 for AgIx). We have therefore shown that after 1 month, oral ascorbic acid lowered arterial blood pressure and improved arterial stiffness in patients with type 2 diabetes. As strict control of blood pressure reduces cardiovascular risk in diabetes, ascorbic acid supplementation may potentially be a useful and inexpensive adjunctive therapy. Larger and longer studies now need to be performed.
Does managed care gatekeeping affect African Americans' access to emergency care? (2001)

A number of national initiatives have focused attention on persistent racial and ethnic disparities in health and health care. The rising tide of improvements in health has not raised all boats; in some cases, the health gap between whites and minorities has widened. Although many social and economic forces contribute to this gap, inequitable access to health care also plays a part. This Issue Brief examines a common strategy that managed care organizations use to reduce emergency department visits--gatekeeping--and describes a study of the differential impact it may have on African Americans.
Interactions between sub-10-nm iron and cerium oxide nanoparticles and 3T3 fibroblasts: the role of the coating and aggregation state (2010)

Recent nanotoxicity studies revealed that the physico-chemical characteristics of engineered nanomaterials play an important role in the interactions with living cells. Here, we report on the toxicity and uptake of cerium and iron oxide sub-10-nm nanoparticles by NIH/3T3 mouse fibroblasts. Coating strategies include low-molecular weight ligands (citric acid) and polymers (poly(acrylic acid), M(W) = 2000 g mol(-1)). Electrostatically adsorbed on the surfaces, the organic moieties provide a negatively charged coating in physiological conditions. We find that most particles were biocompatible, as exposed cells remained 100% viable relative to controls. Only the bare and the citrate-coated nanoceria exhibit a slight decrease in mitochondrial activity at very high cerium concentrations (>1 g l(-1)). We also observe that the citrate-coated particles are internalized/adsorbed by the cells in large amounts, typically 250 pg/cell after 24 h incubation for iron oxide. In contrast, the polymer-coated particles are taken up at much lower rates (<30 pg/cell). The strong uptake shown by the citrated particles is related to the destabilization of the dispersions in the cell culture medium and their sedimentation down to the cell membranes. In conclusion, we show that the uptake of nanomaterials by living cells depends on the coating of the particles and on its ability to preserve the colloidal nature of the dispersions.
Preparation and characterization of Ag<sub>2</sub>S nanoparticles embedded in polymer fibre matrices by electrospinning (2005)

Polyvinylpyrrolidone (PVP)/Ag(2)S composite fibres were successfully prepared by a facile method called the electrospinning technique. Scanning electron microscopy analysis revealed the fibre morphology of the composite. Transmission electron microscopy showed spherical nanoparticles of the Ag(2)S component with an average particle size of about 15 nm and a good dispersion. X-ray diffraction results showed that a pure beta-Ag(2)S phase was obtained in the PVP fibres. X-ray photoelectron spectra (XPS) proved that the Ag and S elements exist in PVP/Ag(2)S composite fibres and quantitative analysis of the XPS showed that the atomic ratio of silver and sulfur was about 2. Fourier transform infrared and ultraviolet-visible spectroscopy were used to characterize the structure of the PVP/Ag(2)S composite fibres.
Automated Software Debugging Using Hybrid Static/Dynamic Analysis (2015)

With the increasing complexity of today's software, the software development process is becoming highly time and resource consuming. The increasing number of software configurations, input parameters, usage scenarios, supporting platforms, external dependencies, and versions plays an important role in expanding the costs of maintaining and repairing unforeseeable software faults. To repair software faults, developers spend considerable time in identifying the scenarios leading to those faults and root-causing the problems. While software debugging remains largely manual, it is not the case with software testing and verification. The goal of this research is to improve the software development process in general, and software debugging process in particular, by devising techniques and methods for automated software debugging, which leverage the advances in automatic test case generation and replay. In this research, novel algorithms are devised to discover faulty execution paths in programs by utilizing already existing software test cases, which can be either automatically or manually generated. The execution traces, or alternatively, the sequence covers of the failing test cases are extracted. Afterwards, commonalities between these test case sequence covers are extracted, processed, analyzed, and then presented to the developers in the form of subsequences that may be causing the fault. The hypothesis is that code sequences that are shared between a number of faulty test cases for the same reason resemble the faulty execution path, and hence, the search space for the faulty execution path can be narrowed down by using a large number of test cases. To achieve this goal, an efficient algorithm is implemented for finding common subsequences among a set of code sequence covers. Optimization techniques are devised to generate shorter and more logical sequence covers, and to select subsequences with high likelihood of containing the root cause among the set of all possible common subsequences. A hybrid static/dynamic analysis approach is designed to trace back the common subsequences from the end to the root cause. A debugging tool is created to enable developers to use the approach, and integrate it with an existing Integrated Development Environment. The tool is also integrated with the environment's program editors so that developers can benefit from both the tool suggestions, and their source code counterparts. Finally, a comparison between the developed approach and the state-of-the-art techniques shows that developers need only to inspect a small number of lines in order to find the root cause of the fault. Furthermore, experimental evaluation shows that the algorithm optimizations lead to better results in terms of both the algorithm running time and the output subsequence length.
Mobile multi-flash photography (2014)

Multi-flash (MF) photography offers a number of advantages over regular photography including removing the effects of illumination, color and texture as well as highlighting occlusion contours. Implementing MF photography on mobile devices, however, is challenging due to their restricted form factors, limited synchronization capabilities, low computational power and limited interface connectivity. In this paper, we present a novel mobile MF technique that overcomes these limitations and achieves comparable performance as conventional MF. We first construct a mobile flash ring using four LED lights and design a special mobile flash-camera synchronization unit. The mobile device’s own flash first triggers the flash ring via an auxiliary photocell. The mobile flashes are then triggered consecutively in sync with the mobile camera’s frame rate, to guarantee that each image is captured with only one LED flash on. To process the acquired MF images, we further develop a class of fast mobile image processing techniques for image registration, depth edge extraction, and edge-preserving smoothing. We demonstrate our mobile MF on a number of mobile imaging applications, including occlusion detection, image thumbnailing, image abstraction and object category classification.
Mask-Guided Portrait Editing with Conditional GANs (2019)

Portrait editing is a popular subject in photo manipulation. The Generative Adversarial Network (GAN) advances the generating of realistic faces and allows more face editing. In this paper, we argue about three issues in existing techniques: diversity, quality, and controllability for portrait synthesis and editing. To address these issues, we propose a novel end-to-end learning framework that leverages conditional GANs guided by provided face masks for generating faces. The framework learns feature embeddings for every face component (e.g., mouth, hair, eye), separately, contributing to better correspondences for image translation, and local face editing. With the mask, our network is available to many applications, like face synthesis driven by mask, face Swap+ (including hair in swapping), and local manipulation. It can also boost the performance of face parsing a bit as an option of data augmentation.
Ocular Hypotensive Effect of ONO-9054, an EP3/FP Receptor Agonist: Results of a Randomized, Placebo-controlled, Dose Escalation Study (2016)

ONO-9054 was well-tolerated and elicited dose-dependent reductions in IOP, which were sustained for at least 24 hours following 2 weeks of consecutive daily dosing.
Image Retrieval Method Based on Vision Feature of Color (2013)

Color histogram is an important technique for color database retrieving, but it often ignores color’s spatial distribution information. This paper proposes an improved color histogram algorithm based on the HSV space, whose subspaces are non-equally quantized. The algorithm first proceeds annular partition on the original image, and then uses the method presented by Aibing Rao etc. [1] to count each partition. At last, it calculates the weighted sums for the distances between distinct color histograms. Experimental results demonstrate that the algorithm reduces the feature dimensions and keeps a good accuracy as well as the spatial distribution information. Thus, a better retrieval result is obtained.
Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non‐diabetic controls (2014)

Patients with type 2 diabetes initiated with metformin monotherapy had longer survival than did matched, non-diabetic controls. Those treated with sulphonylurea had markedly reduced survival compared with both matched controls and those receiving metformin monotherapy. This supports the position of metformin as first-line therapy and implies that metformin may confer benefit in non-diabetes. Sulphonylurea remains a concern.
AN EMPIRICAL ANALYSIS OF WEALTH TAXATION: EQUITY VS. TAX COMPLIANCE (2007)

Capital taxation is currently under debate, basically due to problems of administrative control and proper assessment of the levied assets. We analyze both problems focusing on a capital tax, the annual wealth tax (WT), which is only applied in five OECD countries, being Spain one of them. We concentrate our analysis on top 1% adult population, which permits us to describe the evolution of wealth concentration in Spain along 1983-2001. On average top 1% holds about 18% of total wealth, which rises to 19% when tax incompliance and under-assessment is corrected for housing, the main asset. The evolution suggests wealth concentration has risen. Regarding WT, we analyze whether it helps to reduce wealth inequality or, on the contrary, it reinforces vertical inequity (due to especial concessions) and horizontal inequity (due to the de iure and to de facto different treatment of assets). We analyze in detail housing and equity shares. By means of a time series analysis, we relate the reported values with reasonable price indicators and proxies of the propensity to save. We infer net tax compliance is extremely low, which includes both what we commonly understand by (gross) tax compliance and the degree of under-assessment due to fiscal legislation (for housing). That is especially true for housing, whose level of net tax compliance is well below 50%. Hence, we corroborate the difficulties in taxing capital, and so cast doubts on the current role of the WT in Spain in reducing wealth inequality.
Mechanical properties of nanophase materials (1993)

It has become possible in recent years to synthesize new materials under controlled conditions with constituent structures on a nanometer size scale (below 100 nm). These novel nanophase materials have grain-size dependent mechanical properties significantly different than those of their coarser-grained counterparts. For example, nanophase metals are much stronger and apparently less ductile than conventional metals, while nanophase ceramics are more ductile and more easily formed than conventional ceramics. The observed mechanical property changes are related to grain size limitations and/or the large percentage of atoms in grain boundary environments; they can also be affected by such features as flaw populations, strains and impurity levels that can result from differing synthesis and processing methods. An overview of what is presently known about the mechanical properties of nanophase materials, including both metals and ceramics, is presented. Some possible atomic mechanisms responsible for the observed behavior in these materials are considered in light of their unique structures.