gebhart/patrepeval huggingface dataset:
Effects of CYP3A4 and P-glycoprotein inhibition or induction on the pharmacokinetics of ubrogepant in healthy adults: Two phase 1, open-label, fixed-sequence, single-center, crossover trials (2021)

Background: Ubrogepant is metabolized by cytochrome P450 3A4 (CYP3A4) and is a P-glycoprotein (P-gp) substrate. Objective: To assess effects of multiple-dose moderate-strong CYP3A4 and strong P-gp inhibitors and inducers on ubrogepant pharmacokinetic (PK) parameters. Methods: Two phase 1, open-label, fixed-sequence, single-center, crossover trials enrolled healthy adults to receive ubrogepant 20 mg with/without verapamil 240 mg (a moderate CYP3A4 inhibitor) or ketoconazole 400 mg (a strong CYP3A4 and P-gp transporter inhibitor) (Study A), or ubrogepant 100 mg with/without rifampin 600 mg (a strong CYP3A4 inducer and P-gp inducer) (Study B). Outcomes included ubrogepant PK parameters (area under plasma concentration-time curve, time 0 through infinity [AUC 0-∞ ], peak plasma concentration [C max ]), and safety (treatment-emergent adverse events [TEAEs]). PK parameters were compared between ubrogepant with/without coadministered medications using linear mixed-effects models. C max and AUC 0-∞ least-squares geometric mean ratios (GMR) of ubrogepant with/without coadministration were constructed. Results: Twelve participants enrolled in Study A and 30 in Study B. AUC 0-∞ and C max GMR (90% CI) were 3.53 (3.32–3.75) and 2.80 (2.48–3.15), respectively, for ubrogepant with verapamil; 9.65 (7.27–12.81) and 5.32 (4.19–6.76) with ketoconazole; and 0.22 (0.20–0.24) and 0.31 (0.27–0.36) with rifampin. TEAEs were predominantly mild; no treatment-related serious TEAEs or TEAE-related discontinuations occurred. Conclusion: The PK of ubrogepant were significantly affected by the concomitant use of CYP3A4 moderate-strong inhibitors and strong inducers.
Long-Term Responders on Olaparib Maintenance in High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization (2017)

<b>Purpose:</b> Maintenance therapy with olaparib has improved progression-free survival in women with high-grade serous ovarian cancer (HGSOC), particularly those harboring <i>BRCA1/2</i> mutations. The objective of this study was to characterize long-term (LT) versus short-term (ST) responders to olaparib.<b>Experimental Design:</b> A comparative molecular analysis of Study 19 (NCT00753545), a randomized phase II trial assessing olaparib maintenance after response to platinum-based chemotherapy in HGSOC, was conducted. LT response was defined as response to olaparib/placebo >2 years, ST as <3 months. Molecular analyses included germline <i>BRCA1/2</i> status, three-biomarker homologous recombination deficiency (HRD) score, <i>BRCA1</i> methylation, and mutational profiling. Another olaparib maintenance study (Study 41; NCT01081951) was used as an additional cohort.<b>Results:</b> Thirty-seven LT (32 olaparib) and 61 ST (21 olaparib) patients were identified. Treatment was significantly associated with outcome (<i>P</i> < 0.0001), with more LT patients on olaparib (60.4%) than placebo (11.1%). LT sensitivity to olaparib correlated with complete response to chemotherapy (<i>P</i> < 0.05). In the olaparib LT group, 244 genetic alterations were detected, with <i>TP53, BRCA1</i>, and <i>BRCA2</i> mutations being most common (90%, 25%, and 35%, respectively). <i>BRCA2</i> mutations were enriched among the LT responders. <i>BRCA</i> methylation was not associated with response duration. High myriad HRD score (>42) and/or <i>BRCA1/2</i> mutation was associated with LT response to olaparib. Study 41 confirmed the correlation of LT response with olaparib and <i>BRCA1/2</i> mutation.<b>Conclusions:</b> Findings show that LT response to olaparib may be multifactorial and related to homologous recombination repair deficiency, particularly <i>BRCA1/2</i> defects. The type of <i>BRCA1/2</i> mutation warrants further investigation. <i>Clin Cancer Res; 23(15); 4086-94. ©2017 AACR</i>.
AnkaCom: A Development and Experiment for Extreme Scale Computing (2015)

Extreme scale computing has no implied scaling limit. The impossibility of implementing reliable communication between crashing hosts prohibits explicit-communication primitives in extreme scale applications. However, the alternatives are not well investigated. This paper reports the development and experimentation of a prototype implicit communication system called AnkaCom using a Statistic Multiplexed Computing (SMC) framework. The key concept of the SMC framework is total decoupling between application logical entities and the physical resources, such as processors, networks, databases and storages. The separation allows the integration of a SMC control layer that can automatically deliver mission critical services leveraging the maximal capabilities of the unreliable resources at runtime. The SMC control layer operates according to the principles of HDLC protocols that have been proven capable of delivering exactly once reliable services using unreliable lower level services. This paper reports the development and computational experiments of AnkaCom - an experimental SMC parallel processing system. AnkaCom is a Java implementation of a distributed tuple switch network (TSN) with in-memory replication capabilities. We study computational results of AnkaCom application against "bare metal" C/MPI application using a textbook dense matrix multiplication example. We show that granularity optimized AnkaCom application can consistently out-perform C/MPI application in a dedicated cluster of 12-120 cores. In-memory real time data replication effects are also reported to show marginal elapsed time changes with double and triple runtime tuple replicas.
Thermal management strategies for gallium oxide vertical trench-fin MOSFETs (2021)

Trench-fin MOSFETs, with their near-surface heat generation and the higher-surface area afforded by their geometry for thermal management, represent a promising solution to the thermal problems frequently encountered in lateral β-Ga2O3 devices. Here, we investigate potential thermal-management strategies for a vertical β-Ga2O3 trench-fin MOSFET through parametric analysis, offering recommendations on how best to design a device for maximal current density and excellent thermal performance. Primarily, by using a thermally conductive dielectric over the MOSFET structure, significant improvements to device power density may be achieved, aided by thermal spreading. Additionally, we find that by bonding thermal spreaders to its topside can yield significant improvements in thermal performance.
Design of Low Power Monolithic DC-DC Buck Converter with Integrated Inductor (2006)

This paper presents the design and fabrication of monolithic buck converter using standard CMOS process. As the Q-factor of planar spiral inductor is low in standard CMOS process, this work uses an in-plane inductor built using a CMOS compatible MEMS based technique called PDMA (plastic deformation magnetic assembly). The fabrication process for integrating this air-core, in-plane PDMA inductor is outlined. Optimization of MOS transistors to minimize losses in the buck converter is presented. The design of a 75-mW monolithic buck converter, using AMIS ABN 1.5 mm CMOS process and in-plane PDMA inductor, is outlined. Experimental results from this buck converter are presented
Fracture Bracing (1974)

Professor and Chairman, Department of Orthopaedics and Rehabilitation, School of Medicine, University of Miami, P.O. Box 875, Biscayne, Annex, Miami, Florida 33152
Responses of human keratocytes to micro‐ and nanostructured substrates (2004)

We have previously shown that human corneal epithelial cells respond to synthetic topographic features with dimensions similar to those found in the native human corneal basement membrane. Epithelial cells integrated inputs from substrate topography and soluble factors in the culture medium to generate alignment responses to substrate topographic anisotropies. Human keratocytes are the main cellular components of the stroma, the tissue that underlies the corneal epithelium. Here we report that keratocytes aligned more strongly than epithelial cells along topographic patterns of grooves and ridges. On patterns with pitches of 800 nm and larger approximately 70% of keratocytes were aligned along the patterns compared to 35% for epithelial cells. On 70 nm-wide ridges on a 400-nm pitch, keratocyte alignment dropped to 45%, whereas epithelial cell alignment remained constant. Similarly to epithelial cells, focal adhesions and associated stress fibers in keratocytes were aligned mainly along the substrate topographies, although oblique orientations were also observed. Furthermore, keratocytes cultured on the nanoscale patterns had fewer stress fibers and focal adhesions than cells cultured on microscale patterns or on smooth substrates.
Energy-Aware Prefetching for Parallel Disk Systems: Algorithms, Models, and Evaluation (2009)

Parallel disk systems consume a significant amount of energy due to the large number of disks. To design economically attractive and environmentally friendly parallel disk systems, in this paper we design and evaluate an energy-aware prefetching strategy for parallel disk systems consisting of a small number of buffer disks and large number of data disks. Using buffer disks to temporarily handle requests for data disks, we can keep data disks in the low-power mode as long as possible. Our prefetching algorithm aims to group many small idle periods in data disks to form large idle periods, which in turn allow data disks to remain in the standby state to save energy. To achieve this goal, we utilize buffer disks to aggressively fetch popular data from regular data disks into buffer disks, thereby putting data disks into the standby state for longer time intervals. A centrepiece in the prefetching mechanism is an energy-saving prediction model, based on which we implement the energy-saving calculation module that is invoked in the prefetching algorithm. We quantitatively compare our energy-aware prefetching mechanism against existing solutions, including the dynamic power management strategy. Experimental results confirm that the buffer-disk-based prefetching can significantly reduce energy consumption in parallel disk systems by up to 50 percent. In addition, we systematically investigate the energy efficiency impact that varying disk power parameters has on our prefetching algorithm.
Repeated derecruitments accentuate lung injury during mechanical ventilation* (2002)

Repeated derecruitments can accentuate lung injury during mechanical ventilation.
A Note on Urysohn’s Lemma under mIαg-Normal Spaces and mIαg-Regular Spaces in Ideal Minimal Space (2021)

This research article is concerned with the introduction of a new notion of normal spaces and regular spaces, namely mIαg-normal spaces and mIαg-regular spaces. We established their significant properties in ideal minimal spaces. Some equivalent conditions on mIαg-normal spaces and mIαg-regular spaces are proved. Urysohn's Lemma on mIαg-normal spaces is also established.
Cytochalasin D can improve heterologous protein productivity in adherent Chinese hamster ovary cells (2005)

We generated a series of adherent gene-amplified CHO clones expressing human secreted alkaline phosphatase (SEAP) as a model for heterologous protein production. Clones demonstrate a 26- to 52-fold increase in productivity compared to controls after dhfr/methotrexate-mediated gene amplification and clone selection. SEAP is stably expressed in these clones over at least a 6-week period without significant productivity loss. Two-dimensional protein electrophoresis identified 21 proteins that exhibited altered expression in clones of increasing SEAP productivity. Based on MALDI TOF/TOF mass spectrometry of relevant protein spots, changes in translation, energy pathways, chaperones, regulatory proteins, and cytoskeletal proteins were observed, including a 4-fold expression increase in actin capping protein. We hypothesized that an alteration of the actin cytoskeleton using cytochalasin D as a mimic for actin-capping protein could have a beneficial effect on heterologous protein secretion. Treatment with 0.5 mug/mL cytochalasin D increased SEAP productivity 2- to 3-fold compared to an amplified control which resulted in an increase in productivity from 52- to 150-fold compared to a nonamplified parent.
A key management solution for overlay-live-streaming (2008)

Confidential communication of live-generated multimedia data distributed via application level multicast (ALM) still remains a mostly unaddressed subject even though some important usage scenarios, e.g. paid subscription services or personal video-streaming, are anticipated to gain more widespread use as the Internet continues to evolve into the common transport platform for all kinds of services. In this article, we examine the specific requirements for key management schemes to be used in ALM-based distribution systems and analyze existing key management approaches with respect to these requirements [1, 2, 3]. Based on the results of this analysis, we design a new key management scheme that combines ideas of the Logical Key Hierarchy (LKH) protocol [4, 5] and the Iolus approach [6]. We compare the resulting scheme to a simple approach that is based on pairwise keys between neighboring nodes without further key-hierarchy based optimization and that serves as a benchmark. Our results of a comparative simulation study clearly indicate the suitability of our scheme for ALM-based livestreaming.
<title>Search for optimal infrared projector nonuniformity correction procedures: II</title> (2000)

The one-dimensional nonuniformity scene generation method presented in an earlier paper is extended to the two- dimensional case of real interest. It is shown that the algorithm applied to the one-dimensional case is extendable although its speed of convergence is reduced in two dimensions because of the increased mixing of nonuniformity information. Alternative nonuniformity correction algorithms are developed and compared and it is demonstrated that by utilizing an estimate of the point spread function the scene correction efficiency can be substantially improved.
Oxide Thin‐Film Electronics using All‐MXene Electrical Contacts (2018)

2D MXenes have shown great promise in electrochemical and electromagnetic shielding applications. However, their potential use in electronic devices is significantly less explored. The unique combination of metallic conductivity and hydrophilic surface suggests that MXenes can also be promising in electronics and sensing applications. Here, it is shown that metallic Ti<sub>3</sub> C<sub>2</sub> MXene with work function of 4.60 eV can make good electrical contact with both zinc oxide (ZnO) and tin monoxide (SnO) semiconductors, with negligible band offsets. Consequently, both n-type ZnO and p-type SnO thin-film transistors (TFTs) have been fabricated entirely using large-area MXene (Ti<sub>3</sub> C<sub>2</sub> ) electrical contacts, including gate, source, and drain. The n- and p-type TFTs show balanced performance, including field-effect mobilities of 2.61 and 2.01 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> and switching ratios of 3.6 × 10<sup>6</sup> and 1.1 × 10<sup>3</sup> , respectively. Further, complementary metal oxide semiconductor (CMOS) inverters are demonstrated. The CMOS inverters show large voltage gain of 80 and excellent noise margin of 3.54 V, which is 70.8% of the ideal value. Moreover, the operation of CMOS inverters is shown to be very stable under a 100 Hz square waveform input. The current results suggest that MXene (Ti<sub>3</sub> C<sub>2</sub> ) can play an important role as contact material in nanoelectronics.
Learning Physical Collaborative Robot Behaviors From Human Demonstrations (2016)

Robots are becoming safe and smart enough to work alongside people not only on manufacturing production lines, but also in spaces such as houses, museums, or hospitals. This can be significantly exploited in situations in which a human needs the help of another person to perform a task, because a robot may take the role of the helper. In this sense, a human and the robotic assistant may cooperatively carry out a variety of tasks, therefore requiring the robot to communicate with the person, understand his/her needs, and behave accordingly. To achieve this, we propose a framework for a user to teach a robot collaborative skills from demonstrations. We mainly focus on tasks involving physical contact with the user, in which not only position, but also force sensing and compliance become highly relevant. Specifically, we present an approach that combines probabilistic learning, dynamical systems, and stiffness estimation to encode the robot behavior along the task. Our method allows a robot to learn not only trajectory following skills, but also impedance behaviors. To show the functionality and flexibility of our approach, two different testbeds are used: a transportation task and a collaborative table assembly.
Strategies for Recruiting and Retaining Nurses for Rural Hospital Closure Research (2021)

Purpose: Rural hospital closures result in the loss of lifesaving acute care for rural residents and threaten the health of rural communities significantly. Understanding short- and longer-term effects nurses experiences related to a rural hospital closure can pose a unique challenge, as nurses may relocate and become difficult to identify. In this paper, the authors describe the strategies used during a pandemic to recruit and retain rural nurse research participants who experienced a rural hospital closure. Strategies presented may help nurse researchers recruit a unique and difficult-to-reach rural nurse population during a pandemic. Sample: The sample consisted of nurses who worked in a rural hospital that closed between 2014 to 2020 in one Southwestern state. Method: The authors describe multiple strategies used to recruit rural nurses such as public outreach, social media outreach, and personal outreach. Public outreach was used through professional organization email listservs and printed newspaper advertisements. Social media outreach included public posts online. Personal outreach to former rural hospital employees who were existing contacts was through personal social media messages, phone calls, and texts. Findings: The most effective method for recruitment and retention was personal outreach through rural hospital champions who sent personal messages using social media. The final sample included 10 nurses from two rural hospitals that closed. Five nurses reported about a hospital that closed in 2014, while five nurses reported about a hospital that closed in 2015. Conclusion: For successful recruitment, future researchers should use a direct, personal recruitment strategy to recruit and retain rural nurse research participants for studies about rural hospital closures. Other strategies for successful rural nurse recruitment for research include planning for an extended recruitment timeline, being flexible with participants regarding data collection procedures, cultivating research interest among rural nurses, and building a culture of research in rural settings. Keywords: rural, nursing, research, sampling, recruitment, hospital closure, COVID-19 DOI: https://doi.org/10.14574/ojrnhc.v21i2.682 Acknowledgements: Our study was supported by the Excellence in Research Award sponsored by the Texas Organization of Baccalaureate and Graduate Nursing Education (TOBGNE)
Photonic crystal distributed feedback quantum cascade lasers with 12 W output power (2009)

We demonstrate room temperature, high power, and diffraction limited operation of photonic crystal distributed feedback (PCDFB) quantum cascade lasers emitting around 4.7 μm. PCDFB gratings with three distinctive periods are fabricated on the same wafer. Peak output power up to 12 W is demonstrated. Lasers with different periods show expected wavelength shifts according to the design. Dual mode spectra are attributed to a purer index coupling by putting the grating layer 100 nm away from the laser core. Single lobed diffraction limited far field profiles are observed.
Risk (2015)

Abstract In everyday language, people perceive risks as possibilities of loss or harm. Rather than using such synonyms, it is more helpful to understand risk by key criteria and variables, often in contrast to different antonyms: measurability of risk, manageability of risk, insurability of risk, attributability of risk, voluntariness of risk, and justifiability of risk. These aspects are often interdependent. There is almost an inflation of business risk management checklists, and there are less and more complex lists and models. All lists seem to contain four basic steps for proper risk management procedure: risk identification, risk evaluation, risk control and financing, and taking a risk related decision. Risk ethics also represents a ubiquitous core of “holistic” risk governance, together with risk communication. Questions might focus on exposure to risk – and, importantly, if there is a duty to search for information or if there exists a right to be provided information. The ethical acceptability of risk taking and risk exposure depends on good answers to such questions.
Aerodynamics of Large-Scale Vortex Generator in Ground Effect (2008)

The aerodynamic performance of several vortex generators (VGs) of the type used on the lower surface of race cars was tested in a low-speed wind tunnel. In this particular application, the vortices emanating from the VGs create a suction force between the vehicle and the ground, thereby improving tire adhesion and the vehicle’s cornering∕traction performance. Since the size of these devices is much larger than the local boundary layer thickness, they are termed “large scale” in this study. Results of the wind tunnel tests indicate that the aerodynamic adhesion forces increase with reduced ground clearance while the corresponding drag increase is much smaller. The parameters investigated in this study are the VG length, shape, and the effect of incidence angle. Amongst the various shapes tested, the traditional rectangular VG created the largest forces while the simple triangular design was the most efficient in terms of the incremental lift to drag ratio.
Localization of m-iodo(131I)benzylguanidine in neuroblastoma (1984)

Localization of m-iodo(131I)benzylguanidine in neuroblastomaRS Hattner, JP Huberty, BL Engelstad, CA Gooding and AR AblinAudio Available | Share
Chemotherapy-Induced Cardiotoxicity: Current Practice and Prospects of Prophylaxis (2002)

Cardiotoxicity is a potential side effect of few chemotherapeutic agents. The anthracycline class of cytotoxic antibiotics are the most famous, but other chemotherapeutic agents can also cause serious cardiotoxicity and are not so well recognised. Examples include cyclophosphamide, ifosfamide, mitomycin and fluorouracil. Prediction and hence prophylaxis has always been a difficult task. Ideal monitoring techniques, upon which efficient prophylaxis depends, are yet to be determined. Current prophylaxis relies upon early detection of systolic and/or diastolic dysfunction. While somewhat useful, in some cases by the time defects are detected progression of chemotherapy-induced cardiomyopathy is beyond prevention. Prophylaxis would be much more efficient if a biochemical marker of myocardiocyte damage could be reliably used to stop further chemotherapy at the correct time before irreversible progressive 'macroscopic' damage becomes evident upon imaging. Work is currently progressing to identify the role of markers such as troponins and natriuretic peptides in this regard.