gebhart/patrepeval huggingface dataset:
Channel Prediction by Doppler-Delay Analysis and Benefits for Base Station Cooperation (2013)

Base station cooperation is a promising technique for next generation cellular systems as it reduces intercell interference. In this paper, we investigate to what extent performance degradation due to the feedback delay can be compensated by advanced channel prediction. We present a new method based on a Doppler-delay model of the time-variant radio channel. In a first step, significant channel taps are extracted in the delay domain. In a second step, a high-resolution algorithm extracts the major Doppler frequency components for each channel tap. In this way, a shorter history of the channel is needed, as compared to the standard discrete Fourier transform (DFT) technique. Prediction is performed by imposing the estimated parameters into the channel model and extrapolating into future. Evaluation over the extended spatial channel model (SCME) shows that the channel mean square error can be reduced by roughly 10 dB for feedback delays between 5 and 10 ms, which translates into signal to interference ratio (SIR) gains between 5 and 15 dB, also depending on the number of jointly served terminals. Finally, it is shown that, even if the channel state information (CSI) feedback is quantized, almost the same performance can be achieved as if based on perfect channel knowledge.
Coal-fired power plant risk evaluation strategy (2012)

Today's economic climate requires that each industry aims at achieving maximum production capability, while minimizing capital investment. So, there is an increasing need of risk identification and management during the development, construction and operation process of coal-fired power projects. Presently, the coal-fired power plant construction projects and the risk of operating the initial research is very weak. Using expert investigation method, the most of project risks is obtained and key risk factors are identified. In this paper, a risk evaluation index system of coal-fired power projects during development, construction, and operation has been analyzed. Analyzing external factors, risk indicators, project operations, policy environment, environmental protection, financial situation and then research of construction period to build a risk evaluation index system of coal-fired power plant construction projects. To deal with the identified high degree risk factors, a batch of risks controlling and monitoring measures and strategies are proposed. The application of the measures is tested effectively to resist and control the project risks.
In vitro Models for Adipose Tissue Engineering with Adipose-Derived Stem Cells Using Different Scaffolds of Natural Origin (2011)

Soft tissue regeneration with cell and tissue engineering-based approaches has numerous potential applications in plastic and reconstructive surgery. Adipose-derived stem cells (ASC) have been proved as a feasible source for adipose tissue engineering as they possess high proliferative and differentiation capacity. The purpose of our study was to evaluate adipogenic differentiation of human ASC in four different 3D scaffolds of natural origin, namely human platelet-poor plasma, alginate, fibrin gel and collagen sponge, to define their suitability for adipose tissue engineering and potential clinical applications. ASC were isolated from lipoaspirates of three adult female patients, seeded in the scaffolds, and adipogenic differentiation was induced. After two weeks of cultivation, the constructs were assessed for their mechanical and handling properties, cell viability and adipogenic differentiation. Additionally, the expression of vascular endothelial growth factor (VEGF) was analysed in different culture systems. The results indicate that the levels of specific adipogenic markers and VEGF expression were increased in 3D cultures, as compared to 2D culture. Among 3D scaffolds, fibrin gel showed optimal combination of mechanical characteristics and support of adipogenic differentiation; it was easy to handle, allowed high cell viability, and at the same time supported adipogenic differentiation and VEGF expression.
Fully-gated ground 10T-SRAM bitcell in 45 nm SOI technology (2010)

A novel 10T-SRAM employing a fully-gated grounding scheme (10T-RGND) to limit a memory bitcell (MC) subthreshold leakage current (IOFF) in a 45 nm SOI technology is presented. The source voltage of the read-port of 10T-RGND is selectively grounded by a row decoder only when it is accessed, while those of inactive MCs are forced to a supply voltage (VDD). The number of stackable MCs per bitline (BL) of 10-RGND is increased by 10×, 40%, and 3.5× compared to the conventional 6T, the leakage current-compensating 8T (8T-LC), and the conventional 10T, respectively, at 1.0 V, 125°C, and fast corner process. The total leakage current of 10T-RGND is 6% less than 8T-LC, 17% less than 10T, but 22% larger than 6T in simulation.
Alcohol Adducts of <i>N</i>-Heterocyclic Carbenes:  Latent Catalysts for the Thermally-Controlled Living Polymerization of Cyclic Esters (2006)

Alcohol adducts of the N-heterocyclic carbene, 1,3,4-triphenyl-4,5-dihydro-1H-1,2-triazol-5-ylidene (NHC), function as excellent single-component catalyst/initiators for the ring-opening polymerization of lactide and β-butyrolactone. Their reversible dissociation at elevated temperatures generates alcohol and triazolylidene carbene to provide a facile entry to polymerization of cyclic esters on demand. Under optimum conditions, adverse transesterification reactions are minimized, and importantly, upon complete consumption of monomer, a second monomer addition facilitates additional polymer growth, even after precipitation. Block copolymers were prepared by combining disparate polymerization techniques from the use of oligo-adducts and bifunctional initiators. Additionally, more complex polymer architectures were prepared from multifunctional or dendritic initiators, further demonstrating the versatility of the N-heterocyclic carbene platform.
Reconfigurable consumer direct logistics systems (2005)

The goals of the interdisciplinary project HORN were as well to improve competitiveness of service providers that deliver grocery items as to develop new hardware and software needed for its realisation. In the first part, we introduce this home replenishment project, and analyse the needs and challenges of mobile services with similar constraints. In the second part, we introduce our modular software engineering approach and especially present the adopted reconfiguration mechanism for autonomous mobile applications, and its profiling concept.
Multiple early factors anticipate post-acute COVID-19 sequelae (2022)

Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation of 309 COVID-19 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data and patient-reported symptoms. We resolved four PASC-anticipating risk factors at the time of initial COVID-19 diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, and specific auto-antibodies. In patients with gastrointestinal PASC, SARS-CoV-2-specific and CMV-specific CD8<sup>+</sup> T cells exhibited unique dynamics during recovery from COVID-19. Analysis of symptom-associated immunological signatures revealed coordinated immunity polarization into four endotypes, exhibiting divergent acute severity and PASC. We find that immunological associations between PASC factors diminish over time, leading to distinct convalescent immune states. Detectability of most PASC factors at COVID-19 diagnosis emphasizes the importance of early disease measurements for understanding emergent chronic conditions and suggests PASC treatment strategies.
Study of tricarboxylic acid cycle flux changes in human visual cortex during hemifield visual stimulation using1H-{13C} MRS and fMRI (2001)

The relationships between brain activity and accompanying hemodynamic and metabolic alterations, particularly between the cerebral metabolic rate of oxygen utilization (CMR(O2)) and cerebral blood flow (CBF), are not thoroughly established. CMR(O2) is closely coupled to the rate of tricarboxylic acid (TCA) cycle flux. In this study, the changes in glutamate labeling during (13)C labeled glucose administration were determined in the human brain as an index of alterations in neuronal TCA cycle turnover during increased neuronal activity. Two-volume (1)H-[(13)C] MR spectroscopy (MRS) of the visual cortex was combined with functional MRI (fMRI) at 4 Tesla. Hemifield visual stimulation was employed to obtain data simultaneously from activated and control regions located symmetrically in the two hemispheres of the brain. The results showed that the fractional change in the turnover rate of C4 carbon of glutamate was less than that of CBF during visual stimulation. The fractional changes in CMR(O2) (Delta CMR(O2)) induced by activation must be equal to or less than the fractional change in glutamate labeling kinetics. Therefore, the results impose an upper limit of approximately 30% for Delta CMR(O2) and demonstrate: 1) that fractional CBF increases exceed Delta CMR(O2) during elevated activity in the visual cortex, and 2) that such an unequal change would explain the observed positive blood oxygenation level dependent (BOLD) effect in fMRI. Magn Reson Med 45:349-355, 2001.
Secure Offloading of Legacy IDSes Using Remote VM Introspection in Semi-trusted Clouds (2016)

In Infrastructure-as-a-Service (IaaS) clouds, intrusion detection systems (IDSes) increase their importance. To securely detect attacks against virtual machines (VMs), IDS offloading with VM introspection (VMI) has been proposed. In semi-trusted clouds, however, it is difficult to securely offload IDSes because there may exist insiders such as malicious system administrators. First, secure VM execution cannot coexist with IDS offloading although it has to be enabled to prevent information leakage to insiders. Second, offloaded IDSes can be easily disabled by insiders. To solve these problems, this paper proposes IDS remote offloading with remote VMI. Since IDSes can run at trusted remote hosts outside semi-trusted clouds, they cannot be disabled by insiders in clouds. Remote VMI enables IDSes at remote hosts to introspect VMs via the trusted hypervisor inside semi-trusted clouds. Secure VM execution can be bypassed by performing VMI in the hypervisor. Remote VMI preserves the integrity and confidentiality of introspected data between the hypervisor and remote hosts. The integrity of the hypervisor can be guaranteed by various existing techniques. We have developed RemoteTrans for remotely offloading legacy IDSes and confirmed that RemoteTrans could achieve surprisingly efficient execution of legacy IDSes at remote hosts.
Mobile Robot Topological Map Building Based on Thinning Algorithm (2009)

In order to accomplish navigation and path planning,map building is the key technology and fundamental problem in mobile robotic control in unknown environment.Topological map uses a graph to represent the connectivity of an environment,and it provides a concise description.In this paper the topological map is built based on the grid map by using a thinning algorithm.The environment is modeled in grid map,next the thinning algorithm is applied in the map, and then the effective topological information is extracted.Moreover,the map is robust to environment change,because this map is extracted from a grid map rather than directly uses the original data of the sensor.Simulation results show that the topological map based on thinning algorithm is clear and succinct,and it also avoids producing unnecessary nodes and paths.This topological map stores much less information which will improve the ability of autonomous operation,navigation and path planning further.
'SemanticLIFE' - A Framework for Managing Information of A Human Lifetime. (2004)

The SemanticLIFE' system is designed to store, manage and retrieve ones lifetime’s information entities. It enables the acquisition and storage of data while giving annotations to email messages, browsed web pages, phone calls, images, contacts, life events and other resources. 'SemanticLIFE' 
also provides intuitive and effective search mechanism based upon stored semantics. This paper presents the framework for the system to devise lifetime data store and search using recognized standards. We are aiming at a system which supports the long term memory by associating metadata with content and ontologies. The ultimate goal of our project is to build a Personal Information Management system over a Human Lifetime using ontologies as a basis for the representation of its content.
Curcumin alone and in combination with augmentin protects against pulmonaryinflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice (2010)

Acute lung injuries due to acute lung infections remain a major cause of mortality. Thus a combination of an antibiotic and a compound with immunomodulatory and anti-inflammatory activities can help to overcome acute lung infection-induced injuries. Curcumin derived from the rhizome of turmeric has been used for decades and it exhibits anti-inflammatory, anti-carcinogenic, immunomodulatory properties by downregulation of various inflammatory mediators. Keeping these properties in mind, we investigated the anti-inflammatory properties of curcumin in a mouse model of acute inflammation by introducing Klebsiella pneumoniae B5055 into BALB/c mice via the intranasal route. Intranasal instillation of bacteria in this mouse model of acute pneumonia-induced inflammation resulted in a significant increase in neutrophil infiltration in the lungs along with increased production of various inflammatory mediators [i.e. malondialdehyde (MDA), myeloperoxidase (MPO), nitric oxide (NO), tumour necrosis factor (TNF)-alpha] in the lung tissue. The animals that received curcumin alone orally or in combination with augmentin, 15 days prior to bacterial instillation into the lungs via the intranasal route, showed a significant (P <0.05) decrease in neutrophil influx into the lungs and a significant (P <0.05) decrease in the production of MDA, NO, MPO activity and TNF-alpha levels. Augmentin treatment alone did not decrease the MDA, MPO, NO and TNF-alpha levels significantly (P >0.05) as compared to the control group. We therefore conclude that curcumin ameliorates lung inflammation induced by K. pneumoniae B5055 without significantly (P <0.05) decreasing the bacterial load in the lung tissue whereas augmentin takes care of bacterial proliferation. Hence, curcumin can be used as an adjunct therapy along with antibiotics as an anti-inflammatory or an immunomodulatory agent in the case of acute lung infection.
Efficacy of oral acyclovir treatment of acute herpes zoster. (1988)

Oral acyclovir, 800 mg five times per day for seven days, was compared with placebo in a randomized, double-blind trial conducted at three centers in the United Kingdom. The study group consisted of 364 elderly immunocompetent patients with herpes zoster who were entered within 72 hours of the onset of rash. Acyclovir significantly reduced the times to last new lesion formation (p less than 0.01), loss of vesicles (p less than 0.01), and full crusting (p = 0.03). No significant hastening of rash healing was seen in those who started therapy later than 48 hours after the onset of rash. There was also a significant reduction pain during treatment with acyclovir (p = 0.02). Acyclovir produced no effects on the frequency or severity of post-herpetic neuralgia. No clinically important adverse effects of acyclovir were reported.
Enhancive index for structured document retrieval (2003)

Structured documents, especially XML documents, are made up of a few logical components, such as title, sections, subsections and paragraphs. The components in each structured document can be represented by an ordered tree model, which can also be viewed as a hierarchical concept relationship. To meet the user's requirements for more precise and concentrated search results, the retrieval techniques should allow the user to retrieve document components with varying granularity. To enable this, suitable querying strategies, especially some special indexing techniques must be developed. This paper puts forward an enhancive indexing technique for approximate search by taking advantage of the natural hierarchical structure in text documents. Experiments show that improved performance can be obtained by using such a kind of enhancive indexing technique.
Rapid Mapping of Interactions between Human SNX-BAR Proteins Measured In Vitro by AlphaScreen and Single-molecule Spectroscopy (2014)

Protein dimerization and oligomerization is commonly used by nature to increase the structural and functional complexity of proteins. Regulated protein assembly is essential to transfer information in signaling, transcriptional, and membrane trafficking events. Here we show that a combination of cell-free protein expression, a proximity based interaction assay (AlphaScreen), and single-molecule fluorescence allow rapid mapping of homo- and hetero-oligomerization of proteins. We have applied this approach to the family of BAR domain-containing sorting nexin (SNX-BAR) proteins, which are essential regulators of membrane trafficking and remodeling in all eukaryotes. Dimerization of BAR domains is essential for creating a concave structure capable of sensing and inducing membrane curvature. We have systematically mapped 144 pairwise interactions between the human SNX-BAR proteins and generated an interaction matrix of preferred dimerization partners for each family member. We find that while nine SNX-BAR proteins are able to form homo-dimers, several including the retromer-associated SNX1, SNX2, and SNX5 require heteromeric interactions for dimerization. SNX2, SNX4, SNX6, and SNX8 show a promiscuous ability to bind other SNX-BAR proteins and we also observe a novel interaction with the SNX3 protein which lacks the BAR domain structure.
Parity streams: a novel FEC scheme with the stream control transmission protocol (2006)

Conventional packet-level forward error correction (FEC) is found inapplicable with the stream control transmission protocol (SCTP), because of its partially ordered transport feature. To provide error resilience for respectively ordered data streams, we propose to generate "parity streams" parallel to the data streams. The use of parity streams allows multiple data streams to be protected concurrently and also scalably. For instance, unequal error protection (UEP) can be easily implemented within and/or across data streams, which is attractive to streaming-media applications where preferential treatment on different data units is desired
Rosemary components inhibit benzo[<i>a</i>]pyrene-induced genotoxicity in human bronchial cells (1995)

The commonly used spice and flavouring agent, rosemary, derived from the leaves of the plant Rosmarinus officinalis L., displays antioxidant properties in foods and in biological systems. Moreover, in animal models rosemary components were found to inhibit the initiation and tumour promotion phases of carcinogenesis. In this work, we studied the mechanisms by which rosemary components block initiation of carcinogenesis by the procarcinogen benzo[a]pyrene (B[a]P) in human bronchial epithelial cells (BEAS-2B). Whole rosemary extract (6 micrograms/ml) or an equivalent concentration of its most potent antioxidant constituents, carnosol or carnosic acid, inhibited DNA adduct formation by 80% after 6 h co-incubation with 1.5 muM B[a]P. Under similar conditions, cytochrome P450 (CYP) 1A1 mRNA expression was 50% lower in the presence of rosemary components, and CYP1A1 activity was inhibited 70-90%. The observed reduction of DNA adduct formation by rosemary components may mostly result from the inhibition of the activation of benzo[a]pyrene to its ultimate metabolites. Carnosol also affected expression of the phase II enzyme glutathione-S-transferase which is known to detoxify the proximate carcinogenic metabolite of B[a]P. Treatment of BEAS-2B cells with carnosol (1 microgram/ml) for 24 h resulted in a 3- to 4-fold induction of GST pi mRNA. Moreover, expression of a second important phase II enzyme, NAD(P)H: quinone reductase, was induced by carnosol in parallel with GST pi. Therefore, rosemary components have the potential to decrease activation and increase detoxification of an important human carcinogen, identifying them as promising candidates for chemopreventive programs.
RISUG: an intravasal injectable male contraceptive. (2014)

Over the last two decades RISUG has been drawing attention in the field of male contraception. It promises to sterile men for a period of up to 10-15 years. According to recent studies in animal models, it proves to be completely reversible. Practically, there are no better options available that can assure complete sterility and precise reversibility. Regardless of so much of information available, RISUG is still holding up for many reasons, firstly, the available information engender bewilderment such as what is this copolymer, how does it work and is reversal really possible? Secondly, advancement of this outstanding invention is drastically slow and thirdly, effects of long-term contraception with RISUG and reports on evaluation of anomalies (if any) in F 1 , F 2 progenies, are lacking. In this review the lacunae as well as advances in the development of RISUG in the light of published work and available resources are pointed out. Formulation of the RISUG, its mode of action and clinical trials have been addressed with particular emphasis.
Continuously tuned external cavity semiconductor laser (1993)

Continuous tuning (no mode hops) of a grating-tuned external-cavity semiconductor laser by rotation of the grating about a carefully selected point is analyzed and demonstrated using a laser containing a prism beam expander. The analysis predicts the continuous tuning range as a function of pivot-point position and is used to select the point for maximum continuous tuning range. Because dispersive optical elements in the cavity were found to limit the continuous tuning range, the model was modified to include dispersion to first order. The dispersion correction improved the maximum observed tuning range of the 1300-nm-wavelength laser from 600 GHz to nearly 3000 GHz. Details of the cavity and mechanical design as well as pivot-point tolerances are also included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mobile computing at the edge (keynote) (2014)

As sales of mobile devices grow and smartphones and tablets become for many the preferred way of interacting with the Internet, social media and the enterprise, organizations are striving to push content and functionality out to mobile users. However, mobile devices still do not have the computing power and battery life that will allow them to perform effectively. This keynote explores current and future options for mobile devices to leverage edge networks and servers to extend their computing power and battery life, along with the software engineering challenges and opportunities that this movement brings.
Ambient Temperature Synthesis of High Enantiopurity <i>N</i>-Protected Peptidyl Ketones by Peptidyl Thiol Ester−Boronic Acid Cross-Coupling (2007)

alpha-Amino acid thiol esters derived from N-protected mono-, di-, and tripeptides couple with aryl, pi-electron-rich heteroaryl, or alkenyl boronic acids in the presence of stoichiometric Cu(I) thiophene-2-carboxylate and catalytic Pd(2)(dba)(3)/triethylphosphite to generate the corresponding N-protected peptidyl ketones in good-to-excellent yields and in high enantiopurity. Triethylphosphite plays a key role as a supporting ligand by mitigating an undesired palladium-catalyzed decarbonylation-beta-elimination of the alpha-amino thiol esters. The peptidyl ketone synthesis proceeds at room temperature under nonbasic conditions and demonstrates a high tolerance to functionality.