gebhart/patrepeval huggingface dataset:
Vaccination of multiple myeloma patients with idiotype‐pulsed dendritic cells: immunological and clinical aspects (2000)

Multiple myeloma (MM) is characterized by a clonal proliferation of malignant plasma cells in the bone marrow secreting a monoclonal immunoglobulin (paraprotein) with specific antigenic determinants, the idiotype (Id), which can be regarded as a tumour-associated antigen (TAA). In order to analyse the impact of a dendritic cell (DC)-based vaccine, 11 patients with advanced MM were treated with CD34 stem cell-derived dendritic cells that were pulsed with Id peptides. Subsequently, the patients received three boost immunizations every other week with a combination of Id and granulocyte-macrophage colony-stimulating factor (GM-CSF) (nine patients) or with Id peptide-pulsed dendritic cells again (two patients). The treatment was well tolerated with no side-effects. The present clinical study was a proof of concept analysis of dendritic cell-based vaccines in MM. The capacity of the dendritic cells to activate idiotype-specific T cells was verified by in vitro stimulation experiments before the vaccination therapy. Immunological effects of the Id vaccination were analysed by monitoring changes in anti-idiotype antibody titres and idiotype-specific T-cell activity. After vaccination, three out of 10 analysed patients showed increased anti-idiotype antibody serum titres, indicating the induction of an idiotype-specific humoral immune response. The idiotype-specific T-cell response analysed by ELISpot was increased in four out of 10 analysed patients after vaccination, and one patient had a decreased plasma cell infiltration in the bone marrow. In conclusion, five out of 11 patients showed a biological response after vaccination. Thus, our data indicate that immunotherapy with Id-pulsed DCs in MM patients is feasible and safe. DC generated from CD34+ progenitor cells can serve as a natural adjuvant for the induction of clinically relevant humoral and cellular idiotype-specific immune responses in patients suffering from advanced MM.
Contribution of the Symbiotic Plasmid to the Competitiveness of Rhizobium leguminosarum (1983)

Four different symbiotic plasmids from Rhizobium leguminosarum were introduced into three different recipient strains that lacked plasmid-linked symbiotic determinants. The twelve synthetic strains so constructed were each tested for competitiveness against a standard reference strain. The recipient strain and the introduced symbiotic plasmid contributed about equally to competitiveness in forming root nodules on pea plants: there was also significant interaction between strain and plasmid, although this was much less important than the main effects. Competitiveness for growth on the legume root surface (the rhizosphere) was attributable entirely to the recipient strain; the introduced plasmid had no significant effect.
Digital Audio Watermarking Based on Artificial Neural Networks (2012)

A digital audio watermarking based on artificial neural networks is proposed in this paper. Utilizing the learning and adaptive capabilities of artificial neural networks, the relationship between audio signals and embedded watermark is established by using the important characters of audio signals as the input vector of artificial neural networks, and the watermark were embedded into original audio signals without modifying the audio data. The experimental results show that the embedded watermark is robust to audio signal processing, and the watermarking method does not require the original audio signals for watermarking extraction.
Multiple Mechanisms of Transcriptional Repression by YY1 (1997)

The four C-terminal GLI-Krüppel type zinc fingers of YY1 have been identified as a transcriptional repression domain. Previous reports have proposed DNA-bending and activator-quenching mechanisms for this zinc finger-mediated repression. In addition, previous work indicated that p300 and CBP might be involved in YY1-mediated repression. We have analyzed these possible models for the zinc finger-mediated repression. The role of each zinc finger in the repression and DNA-binding functions was determined by using a structure-and-function approach. We show that zinc finger 2 of YY1 plays a central role in both DNA binding and transcriptional repression. However, a survey of a panel of YY1 mutants indicates that these two functions can be separated, which argues against the DNA-bending model for repression. We show that the physical interaction between YY1 and p300, a coactivator for CREB, is not sufficient for repression of CREB-mediated transcription. Our studies indicate that YY1 functions as an activator-specific repressor. Repression of CTF-1-directed transcription may be accomplished through direct physical interaction between YY1 and this activator. In contrast, physical interaction is not necessary for YY1 to repress Sp1- and CREB-mediated transcription. Rather, the repression likely reflects an ability of YY1 to interfere with communication between these activators and their targets within the general transcription machinery. Taken together, our results suggest that YY1 employs multiple mechanisms to achieve activator-specific repression.
.omega.-[(4-Phenyl-2-quinolyl)oxy]alkanoic acid derivatives: a new family of potent LTB4 antagonists (1992)

A series of omega-[(4-phenyl-2-quinolyl)oxy]alkanoic acid derivatives was prepared which inhibited the binding of the leukotriene B4 to its receptors on guinea pig spleen membranes and on human polymorphonuclear leukocytes. A structure-activity relationship was investigated. The length of the carboxylic acid side chain was important for potent binding activity. The replacement of the oxygen atom at the beginning of the chain with other polar or nonpolar linking groups led to considerable loss of potency, indicating that the oxygen linking atom might be involved in the receptor recognition. alpha-Substitution on the carboxylic acid side chain led to substantially more potent compounds. Substitution on the phenyl ring and on the quinoline ring was also evaluated.
Using OSGi UPnP and Zigbee to Provide a Wireless Ubiquitous Home Healthcare Environment (2008)

In our research we have designed and implemented a ubiquitous home healthcare environment utilizing three novel technologies. We connect portable medical devices and a healthcare gateway via Zigbee which is alow-cost, long-battery-life, and easy-to-setup wireless transmission protocol. Then we convert the Zigbee medical devices into UPnP devices which can be discovered and configured automatically. Finally we manage the software in the healthcare gateway by OSGi with TR-069, so service provider can maintain the system and fix problem without truckroll to user's home. Moreover, to improve the usability, we implement a TV user interface by leveraging the benefit of MHP. User can control the devices via a TV remote controller, and the measurement results displayed on the big screen will be more readable forthe elderly.
A decade of OS access-control extensibility (2013)

Open source security foundations for mobile and embedded devices.
Biomarkers of Aggressive Prostate Cancer at Diagnosis (2023)

In the United States, prostate cancer (CaP) remains the second leading cause of cancer deaths in men. CaP is predominantly indolent at diagnosis, with a small fraction (25-30%) representing an aggressive subtype (Gleason score 7-10) that is prone to metastatic progression. This fact, coupled with the criticism surrounding the role of prostate specific antigen in prostate cancer screening, demonstrates the current need for a biomarker(s) that can identify clinically significant CaP and avoid unnecessary biopsy procedures and psychological implications of being diagnosed with low-risk prostate cancer. Although several diagnostic biomarkers are available to clinicians, very few comparative trials have been performed to assess the clinical effectiveness of these biomarkers. It is of note, however, that a majority of these clinical trials have been over-represented by men of Caucasian origin, despite the fact that African American men have a 1.7 times higher incidence and 2.1 times higher rate of mortality from prostate cancer. Biomarkers for CaP diagnosis based on the tissue of origin include urine-based gene expression assays (PCA3, Select MDx, ExoDx Prostate IntelliScore, Mi-Prostate Score, PCA3-PCGEM1 gene panel), blood-based protein biomarkers (4K, PHI), and tissue-based DNA biomarker (Confirm MDx). Another potential direction that has emerged to aid in the CaP diagnosis include multi-parametric magnetic resonance imaging (mpMRI) and bi-parametric magnetic resonance imaging (bpMRI), which in conjunction with clinically validated biomarkers may provide a better approach to predict clinically significant CaP at diagnosis. In this review, we discuss some of the adjunctive biomarker tests along with newer imaging modalities that are currently available to help clinicians decide which patients are at risk of having high-grade CaP on prostate biopsy with the emphasis on clinical utility of the tests across African American (AA) and Caucasian (CA) men.
Intra- and Inter-Molecular Cross-Linking of Peptide Ions in the Gas Phase: Reagents and Conditions (2011)

Intra-molecular and inter-molecular cross-linking of protonated polypeptide ions in the gas phase via ion/ion reactions have been demonstrated using N-hydroxysulfosuccinimide (sulfo-NHS)- based reagent anions. The initial step in the ion/ion reaction involves the formation of a long-lived complex between the peptide and reagent, which is a prerequisite for the covalent bioconjugation chemistry. The sulfonate groups on the NHS rings of the homo-bifunctional cross-linking reagents have high affinity for the protonated sites in the peptide and, therefore, facilitate the long-lived complex formation. In addition to the formation of a long-lived chemical complex, intra-molecular cross-linking also requires two unprotonated primary amine sites within a molecule where the covalent modification takes place. Alternatively, inter-molecular cross-linking demands the availability of one neutral primary amine site in each of the two peptides that are being cross-linked. Nucleophilic displacement of two sulfo-NHS groups by the amine functionalities in the peptide is a signature of the covalent cross-linking chemistry in the gas phase. Upon removal of the two sulfo-NHS groups, two amide bonds are formed between an unprotonated, primary amine group of a lysine side chain in the peptide and the carboxyl group in the reagent.
<title>Sol-gel coating-based fiber O<formula><inf><roman>2</roman></inf></formula>/DO sensors</title> (1994)

An intrinsic fiber optic environmental sensor has been developed for on-line monitoring of oxygen gas and dissolved oxygen (DO). In this O<SUB>2</SUB>/DO sensor, a highly stable compound [Tris-(4,7-Diphenyl-1, 10-phenanthroline) Ruthenium (II) complex] is synthesized and selected as a chemical indicator for oxygen. A hybrid matrix is designed by a sol-gel process and used as a stable substrate for the immobilization of Ru compound. The microporous nature of the nondensified sol-gel coating, in which the photochemical dye is immobilized, provides a unique local structure that is environmentally stable and immune to photochemical bleaching and chemical leaching. The doped hybrid material is then coated on a porous optical fiber substrate used as the sensing component. The oxygen penetrates into the interconnective porous core and interacts with the immobilized Ru compound in which in-line dynamic luminescence quenching takes place. The use of Ru(ph2phen)3[2+] as a highly stable, reagent sensing indicator and also the use of the sol-gel coating technique for the immobilization and incorporation of Ru compound to porous core optical fibers have resulted in the development of an intrinsic O<SUB>2</SUB>/DO sensor with high sensitivity, reproducibility, and long-term stability.
Novel therapies for relapsed myeloma (2009)

Treatment of myeloma relapse needs to be individualized to reflect the effectiveness and toxicities of prior therapies, with consideration given to pragmatic issues such as the tempo of relapse, age of the patient, access to drugs and patient preference. In general, combination therapies have been associated with higher response rates and improved progression-free survival and may be preferable when a rapid response is required. Nevertheless, in a slower-tempo relapse it is unclear at this juncture whether sequencing of drugs or multi-agent combinations offer superior overall survival results. Fortunately, active novel agents that offer further possibilities for some myeloma patients have become available in clinical trials. In this review we will describe the various classes of novel drugs being tested and the pros and cons of preclinical testing, and will particularly focus on two agents with single-agent activity in myeloma: carfilzomib, a proteasome inhibitor, and pomalidomide, a member of the immunomodulatory class of drugs.
2-Benzazepines. I. Synthesis of 2-benzazepin-4-ones and -5-ones via 2-acetylenic benzophenones (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Benzazepines. I. Synthesis of 2-benzazepin-4-ones and -5-ones via 2-acetylenic benzophenonesEugene J. Trybulski, Earl Reeder, John F. Blount, Armin Walser, and R. Ian FryerCite this: J. Org. Chem. 1982, 47, 12, 2441–2447Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/jo00133a040https://doi.org/10.1021/jo00133a040research-articleACS PublicationsRequest reuse permissionsArticle Views500Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Entropy-Based Algorithm For Reducing Artifacts In Image Restoration (1987)

We introduce a simple algorithm to reduce artifacts that often appear in image restoration techniques such as Wiener filtering. The algorithm starts with the inverse filter solution and iteratively calculates the correction term. At each iteration we use an entropy gradient and an analytically calculated step size. The algorithm uses two Fourier transforms per iteration. We show both 1 -D and 2-D examples to illustrate the algorithm.
Magnetic snubber using amorphous saturable reactor-amorphous beads (2003)

In switching regulators, a magnetic snubber connected to the output diode effectively suppresses spike voltage of the diode and output voltage noise. The principle theory is described and three types of magnetic snubbers are compared. The three types include snubbers incorporating ferrite beads, amorphous beads, and a high-rectangular reactor (spike killer). Newly developed amorphous beads are emphasized.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
New progress of reason research on internet addiction (2011)

【Objective】 To discuss new progress of reason research on internet addiction research both in home and abroad.【Methods】 2000 article were selected and analyzed with analysis of documents method.【Results】 There is a lot of argument about the definition of internet addiction.There are many factors lead to internet addiction such as the basic psychological features of cyberspace,personality trait,cognitive features,family education,social support,school education and management,etc.There are many interpretation models about internet addiction such as ACE model,cognition behavior model,stage model and lose the back-off hypothesis.【Conclusion】 The internet addiction and relevance problem is the focal point that the general public shows solicitude for.Although many study have a divergence,we all admitted that we should carry out analysis on it from many ways such as biological,psychological and social factor.
Dietary Fiber in Brewed Coffee (2007)

Coffee beans are rich in nondigestible polysaccharides (dietary fiber), which may partially pass into brewed coffee; however, to the authors' knowledge, there is not enough literature on dietary fiber in brewed coffee. A specific method to determine dietary fiber in beverages (enzymatic treatment plus dialysis) was applied to the coffees brewed by the most common methods (espresso, filter, soluble); results showed that brewed coffee contained a significantly higher amount of soluble dietary fiber (0.47-0.75 g/100 mL of coffee) than other common beverages. Coffee dietary fiber contains a large amount of associated antioxidant phenolics (8.7-10.5 mg/100 mL of brewed coffee).
Los procesos cognitivos de revisión en la producción textual. (2010)

En este escrito se abordan investigaciones teóricas y empíricas que desarrollan conceptualizaciones en torno a los procesos cognitivos involucrados en la composición textual, en particular se analiza el proceso de revisión que alude a las evaluaciones realizadas por el sujeto sobre su propio texto –planes, borradores, notas, escritos en general – y las posibilidades de realizar ajustes y correcciones. Estos procesos son de gran interés para la disciplina psicológica porque implican funcionamientos de orden cognitivo y metacognitivo dado que el sujeto vuelve sobre su propio pensamiento y sobre el discurso ya elaborado, para evaluar la adecuación, pertinencia y coherencia de lo propuesto. Los procesos derevisión son considerados como los más importantes y constitutivos de la naturaleza de la composición escrita, ellos han sido conceptualizados e investigados por Flower y Hayes, Scardamalia y Bereiter, Camps, McCutchen, Cassany, Allan y Chanquoy, Miras, Rijlaarsdam, Couzijn y Van Den Bergh, entre otros; autores de referencia en este artículo para la reflexión sobre el proceso de revisión en la producción textual en niños. A partir del panorama propuesto se plantea una reflexión sobre las implicaciones de la concepción de escritura, el reconocimiento de las competencias y los procesos puestos en marcha por los niños en la educación y en las propuestas pedagógicas.
Towards production-run heisenbugs reproduction on commercial hardware (2017)

We present a new technique, H3, for reproducing Heisenbugs in production runs on commercial hardware. H3 integrates the hardware control flow tracing capability provided in recent Intel processors with symbolic constraint analysis. Compared to a state-of-the-art solution, CLAP, this integration allows H3 to reproduce failures with much lower runtime overhead and much more compact trace. Moreover, it allows us to develop a highly effective core-based constraint reduction technique that significantly reduces the complexity of the generated symbolic constraints. H3 has been implemented for C/C++ and evaluated on both popular benchmarks and real-world applications. It reproduces realworld Heisenbugs with overhead ranging between 1.4%- 23.4%, up to 8X more efficient than CLAP, and incurs only 4.9% runtime overhead on PARSEC benchmarks.
Complex Ligand-Induced Conformational Changes in tRNA <sup>Asp</sup> Revealed by Single-Nucleotide Resolution SHAPE Chemistry (2008)

RNA conformation is both highly dependent on and sensitive to the presence of charged ligands. Mono- and divalent ions stabilize the native fold of RNA, whereas other polyvalent cationic ligands can act to both stabilize or disrupt native RNA structure. In this work, we analyze the effects of two ligands, Mg (2+) and tobramycin, on the folding of S. cerevisiae tRNA (Asp) transcripts using single nucleotide resolution SHAPE chemistry. Surprisingly, reducing the Mg (2+) concentration favors a structural rearrangement in which the D- and variable loops pair. The tobramycin polycation binds to loops in tRNA (Asp) and induces RNA unfolding in two distinct transitions: the loss of tertiary interactions between the T- and D-loops followed by complete unfolding of the D-stem. Although Mg (2+) and tobramycin are relatively simple ligands, both modulate tRNA (Asp) folding in unanticipatedly complex ways, neither of which is consistent with simple hierarchical folding or unfolding of this RNA. Monitoring the structural consequences of ligand binding to RNA at single nucleotide resolution makes it possible to define intermediate structures that contribute to the complex energy landscapes often observed for RNA folding processes and lays the groundwork for a significantly improved understanding of the interactions between RNA and its solution environment.
Role of Adhesins and Toxins in Invasion of Human Tracheal Epithelial Cells by <i>Bordetella pertussis</i> (2000)

Bordetella pertussis, the agent of whooping cough, can invade and survive in several types of eukaryotic cell, including CHO, HeLa 229, and HEp-2 cells and macrophages. In this study, we analyzed bacterial invasiveness in nonrespiratory human HeLa epithelial cells and human HTE and HAE0 tracheal epithelial cells. Invasion assays and transmission electron microscopy analysis showed that B. pertussis strains invaded and survived, without multiplying, in HTE or HAE0 cells. This phenomenon was bvg regulated, but invasive properties differed between B. pertussis strains and isolates and the B. pertussis reference strain. Studies with B. pertussis mutant strains demonstrated that filamentous hemagglutinin, the major adhesin, was involved in the invasion of human tracheal epithelial cells by bacteria but not in that of HeLa cells. Fimbriae and pertussis toxin were not found to be involved. However, we found that the production of adenylate cyclase-hemolysin prevents the invasion of HeLa and HTE cells by B. pertussis because an adenylate cyclase-hemolysin-deficient mutant was found to be more invasive than the parental strain. The effect of adenylate cyclase-hemolysin was mediated by an increase in the cyclic AMP concentration in the cells. Pertactin (PRN), an adhesin, significantly inhibited the invasion of HTE cells by bacteria, probably via its interaction with adenylate cyclase-hemolysin. Isolates producing different PRNs were taken up similarly, indicating that the differences in the sequences of the PRNs produced by these isolates do not affect invasion. We concluded that filamentous hemagglutinin production favored invasion of human tracheal cells but that adenylate cyclase-hemolysin and PRN production significantly inhibited this process.
Potentiation of Metastatic Capacity by Transforming Growth Factor‐β1 Gene Transfection (1993)

This study was designed to assess whether the excessive secretion of transforming growth factor-beta 1 (TGF-beta 1) by Chinese hamster ovary (CHO) cells transfected with TGF-beta 1 gene may be linked to the development of a metastatic phenotype. We observed large numbers of metastatic colonies in the lungs of nude mice inoculated with the transfected CHO cells. The tumors derived from these transfected cells demonstrated marked angiogenesis. We postulate that the overproduction of TGF-beta 1 by these tumors may participate in the metastatic progression following establishment of angiogenesis at the primary tumor site.