gebhart/patrepeval huggingface dataset:
Atlas-registration based image segmentation of MRI human thigh muscles in 3D space (2014)

Automatic segmentation of anatomic structures of magnetic resonance thigh scans can be a challenging task due to the potential lack of precisely defined muscle boundaries and issues related to intensity inhomogeneity or bias field across an image. In this paper, we demonstrate a combination framework of atlas construction and image registration methods to propagate the desired region of interest (ROI) between atlas image and the targeted MRI thigh scans for quadriceps muscles, femur cortical layer and bone marrow segmentations. The proposed system employs a semi-automatic segmentation method on an initial image in one dataset (from a series of images). The segmented initial image is then used as an atlas image to automate the segmentation of other images in the MRI scans (3-D space). The processes include: ROI labeling, atlas construction and registration, and morphological transform correspondence pixels (in terms of feature and intensity value) between the atlas (template) image and the targeted image based on the prior atlas information and non-rigid image registration methods.
Growth of calcium phosphate on hydroxyapatite crystals. Effect of supersaturation and ionic medium (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGrowth of calcium phosphate on hydroxyapatite crystals. Effect of supersaturation and ionic mediumG. H. Nancollas and B. TomazicCite this: J. Phys. Chem. 1974, 78, 22, 2218–2225Publication Date (Print):October 1, 1974Publication History Published online1 May 2002Published inissue 1 October 1974https://pubs.acs.org/doi/10.1021/j100615a007https://doi.org/10.1021/j100615a007research-articleACS PublicationsRequest reuse permissionsArticle Views1426Altmetric-Citations214LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
PriPeARL (2018)

Preserving privacy of users is a key requirement of web-scale analytics and reporting applications, and has witnessed a renewed focus in light of recent data breaches and new regulations such as GDPR. We focus on the problem of computing robust, reliable analytics in a privacy-preserving manner, while satisfying product requirements. We present PriPeARL, a framework for privacy-preserving analytics and reporting, inspired by differential privacy. We describe the overall design and architecture, and the key modeling components, focusing on the unique challenges associated with privacy, coverage, utility, and consistency. We perform an experimental study in the context of ads analytics and reporting at LinkedIn, thereby demonstrating the tradeoffs between privacy and utility needs, and the applicability of privacy-preserving mechanisms to real-world data. We also highlight the lessons learned from the production deployment of our system at LinkedIn.
Chest pain in primary care: Epidemiology and pre-work-up probabilities (2009)

The study adds important information about the epidemiology of chest pain as a frequent reason for consulting primary care practitioners. We provide updated pre-work-up probabilities for IHD for each age and sex category.
Design and simulation of an innovative micro-magnetic module with dual-function of actuator and sensor (2009)

An innovative magnetic module which is concurrently capable of performing as an actuator and a sensor is proposed and illustrated. The magnetic module is basically similar to a micro-scale Linear Variable Differential Transformer (LVDT) which is employed to actively adjust the height of a rotating seismic disc used in a gyroscope so that the induced pitch angle by Coriolis effect, purely due to exerted angular excitation, can be accurately measured. That is, the micro-magnetic module acts like an actuator for height regulation on the seismic proof mass by applying appropriate electric current to the primary coil of the LVDT. On the other hand, the secondary coil pair of the LVDT acts as a sensor which can detect the gap change between the seismic rotating disc doped by magnetic material and the micro-magnetic module and the rotation speed (i.e., frequency) by measurement of the peaks of sine wave of induced electric current.
Fast digital zooming system using directionally adaptive image interpolation and restoration (2014)

This paper presents a fast digital zooming system for mobile consumer cameras using directionally adaptive image interpolation and restoration methods. The proposed interpolation algorithm performs edge refinement along the initially estimated edge orientation using directionally steerable filters. Either the directionally weighted linear or adaptive cubic-spline interpolation filter is then selectively used according to the refined edge orientation for removing jagged artifacts in the slanted edge region. A novel image restoration algorithm is also presented for removing blurring artifacts caused by the linear or cubic-spline interpolation using the directionally adaptive truncated constrained least squares (TCLS) filter. Both proposed steerable filter-based interpolation and the TCLS-based restoration filters have a finite impulse response (FIR) structure for real time processing in an image signal processing (ISP) chain. Experimental results show that the proposed digital zooming system provides high-quality magnified images with FIR filter-based fast computational structure.
Fine-grain parallelism and run-time decision-making (1996)

While parallel programming is needed to solve large-scale scientific applications, it is more difficult than sequential programming. Programming parallel machines requires specifying what can execute concurrently, when and how processes communicate, and how data is placed in the memories of the processors. The challenge is to address these issues simply, portably, and efficiently. This dissertation presents the Filaments package, which provides fine-grain parallelism and a shared-memory programming model and makes extensive use of run-time decisions. Fine-grain parallelism and a shared-memory programming model simplify parallel programs by allowing the programmer or compiler to concentrate on the application and not the architecture of the target machine. This dissertation shows that this simpler programming model can be implemented with low overhead. Determining the best data placement at run time frees the programmer or compiler from this task and allows the placement to adapt to the particular application. The dissertation discusses the implementation of Adapt, a run-time data placement system, and compare its performance to static placements on three classes of applications. The performance of programs using Adapt is better than those using static data placements on adaptive applications such as particle simulation.
Production and purification (2004)

Volume 1:- 1. Concepts in Development of Manufacturing Strategies for Monoclonal Antibodies B. Fish. 2. Antibody Fragments: Production, Purification and Formatting for Therapeutic Applications D.J. Glover, D.P. Humphreys. 3. Large Scale Production of Therapeutic Antibodies: Considerations for Optimizing Product Capture and Purification G. Kemp, P. O'Neil. 4. Scale-Up of Antibody Purification. From Laboratory Scale to Production L.R. Jacob, M. Frech. 5. Purification of Antibody by Chromatographic Methods C. Vandevyver, R. Freitag. 6. Quality Control of Antibodies for Human Use A. Richter, M. Jostameling, K. Muller, A. Herrmann, M. Pitschke. 7. Expression of Human Anti Rh(D) Monoclonal Antibodies into Different Cell lines: Influence on their Functional Properties C. de Romeuf, C. Gaucher, A. Glacet, S. Jorieux, P. Klein, D. Bourel. 8. Monoclonal Antibody Production: Minimising Virus Safety Issues J. Bray, M.K. Brattle. 9. Contract Manufacturing of Biopharmaceutical Grade Antibodies L.A. Van Der Pol, D.F. Westra. 10. The Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies D.B. Haughey, P.M. Jardieu. 11. Regulatory and Legal Requirements for the Manufacture of Antibodies L. Tsang. Index. Volume 2:- 1. Transgenic technology for monoclonal antibody production S. Sensoli. 2. Generation, engineering and production of human antibodies using HuCAL R. Ostendorp, C. Frisch, M. Urban. 3. Achieving appropriate glycosylation during the scaleup of antibody production X.K. Deng, T. Shantha Raju, K.J. Morrow Jr. 4. Approaches to devise antibody purification processes by chromatography E. Boschetti. 5. Novel HIV neutralizing antibodies selected from phage display libraries M. Moulard, Mei-Yun Zhang, D.S. Dimitrov. 6. Monoclonal and bispecific antibodies in combination with radiotherapy for cancer treatment D. Azria, C. Larbouret, B. Robert, M. Ozsahin, J.B. Dubois, A. Pelegrin. 7. Antibodies, a potent tool to target genes into designated cells and tissues F. Hirsch, O. Deas, G. Carvalho, A. Durrbach, D. Thierry, A. Chapel. 8. Intrabodies: development and application in functional genomics and therapy A. Barberis, A. Auf Der Maur, K. Tissot, P. Lichtlen. 9. Expression of recombinant antibodies by tumour cells: on road to anti-tumour therapy E. Bonnin, J.-L. Teillaud. 10. Antitumor antibodies: from research to clinic S. Menard, S.M. Pupa, M. Campiglio, E. Tagliabue. 11. Macrophages for immunotherapy D. Loirat, S. Jacod, A. Boyer, F. Auzelle, A. McAllister, J.-P. Abstado, J. Bartholeyns, D. Prigent. 12. Future prospects in antibody engineering and therapy S. Siberil, J.-L. Teillaud. Index.
Multiresponsive Kinematics and Robotics of Surface-Patterned Polymer Film (2018)

Soft robots, sensors, and energy harvesters require materials that are capable of converting external stimuli to visible deformations, especially when shape-programmable deformations are desired. Herein, we develop a polymer film that can reversibly respond to humidity, heating, and acetone vapors with the generation of shape-programmable large deformations. Poly(vinylidene fluoride) film, capable of providing acetone responsiveness, is designed with microchannel patterns created on its one side by using templates, and the microchannels-patterned side is then treated with hygroscopic 3-aminopropyltriethoxysilane (APTES) to give humidity/heating-responsive elements. The APTES-modified microchannels lead to anisotropic flexural modulus and hygroscopicity in the film, resulting in the shape-programmed kinematics depending on the orientations of surface microchannels. As the microchannels align at oblique/right angles with respect to the long axis of the film strips, the coiling/curling motions can be generated in response to the stimuli, and the better motion performances are found in humidity- and heating-driven systems. This material utilized in self-adaptive soft robots exhibits prominent toughness, powerful strength, and long endurance for converting humidity and heat to mechanical works including transportation of lightweight objects, automatic sensing cap, and mimicking crawling in nature. We thus believe that this material with shape-programmable multisensing capability might be suitable for soft machines and robotics.
A dual mode GaAs HBT power amplifier for LTE applications (2010)

In this paper, a dual mode GaAs HBT power amplifier for LTE band I applications is present. The amplifier is designed to operate from 1.92 GHz to 1.98 GHz with 28 dB of gain, enough to work with transmitter chips with relative low output power. The amplifier deliveries 28 dBm of linear power at 3.4 V supply to satisfy the linearity requirement for the LTE application. To improve the average efficiency of the amplifier, a new structure of dual mode is proposed. At the high power mode, the efficiency of the amplifier is 34% at 28 dBm of CW output power, and at the low power mode, the efficiency of that is 22% at 15 dBm output power.
Neural-network-based parasitic modeling and extraction verification for RF/millimeter-wave integrated circuit design (2006)

This paper reports an interconnect modeling approach for RF and millimeter-wave integrated circuits (ICs) using neural network models and a novel parasitic extraction verification procedure using automatically generated test structures. The effects of the parasitics in RF/millimeter-wave ICs are investigated with special focus on the parasitic inductances, since they are not evaluated by most of the commercially available extraction tools. State-of-the-art silicon-based multilayer RF process parameters are utilized to extract the resistive, the capacitive, and the inductive components of the layout interconnects. Neural network models are developed using electromagnetic (EM) simulation results of a set of passive interconnect structures. In addition, an automated layout generation methodology is used for the verification of the parasitic extraction methodologies. The proposed verification approach is demonstrated using automatically generated passive test structures and ring oscillators. The effects of parasitics are also investigated in voltage-controlled oscillators (VCOs) and amplifiers for millimeter-wave applications, and the neural models are verified using 30-GHz VCO measurement results. Hence, we present a complete modeling report of layout interconnect parasitics in RF/millimeter-wave integrated circuits as well as a novel verification procedure to validate non-EM analytical or neural models.
Comparative study of high performance GPS receiving antenna designs (2002)

A major factor in the performance of a differential Global Positioning System (DGPS) ground station is the performance of the antenna. The article analyzes and compares the performance of different GPS antenna designs. The specifications for the DGPS ground station antenna include hemispherical coverage and good multipath rejection. Good multipath rejection can be achieved by using an antenna that presents circular polarization and sharp drop-off at low elevation angles. In more detail, the specifications for the high precision GPS antenna include right hand circular polarization with a minimum of 15 dB of cross polarization rejection, hemispherical coverage presenting a variation of less than 3 dB over the main beam and a drop-off rate larger than 1 dB/deg for elevation angles from -5 to 5 deg. These specifications should be satisfied at the frequencies of 1.227 GHz and 1.575 GHz. The antenna designs examined in our study include patch antennas, helical antennas and conical spiral antennas. The numerical results from a successful conical spiral antenna design were verified experimentally.
Collision avoidance and resolution multiple access for multichannel wireless networks (2002)

We introduce and analyze CARMA-MC (for collision avoidance and resolution multiple access for multiple channels), a new stable channel access protocol for multihop wireless networks with multiple channels. CARMA-MC relies on the assignment of a unique channel and a unique identifier to each node to support correct deterministic collision resolution in the presence of hidden terminals. CARMA-MC dynamically divides the channel of each node into cycles of variable length; each cycle consists of one or more receiving periods and a transmission period. During the receiving period, stations with one or more packets to send compete for the right to acquire the floor of a particular receiver's channel using a deterministic tree-splitting algorithm. Each receiving period consists of collision resolution steps. A single round of collision resolution (i.e., a success, and idle or a collision of control packets) is allowed in each contention step. The receiving period is initiated by the receiver and takes place in the channel assigned to the receiver station. The channel utilization and packet delays are studied analytically and by simulation.
[Activation of NF-kappa B in the mouse retina after ischemia reperfusion]. (2003)

Activation of NF-kappa B appears to play an important role in retinal degeneration following retinal ischemia and reperfusion injury. The pro- and anti-apoptotic effects of NF-kappa B after retinal ischemia are being further investigated.
Implementing touchme paradigm with a mobile phone (2005)

In earlier papers, the concept of Physical Browsing has been suggested as a natural way to improve the usability of mobile devices and to enable interaction with digital services associated with real world objects in the environment. Since mobile phones are very widely used, it offers a good platform for pervasive applications. In this paper, we realize the Physical Browsing concept using an RFID-reader. With the reader attached to the mobile phone, we invoke digital services embedded in the environment. The implementation of the software needed for ubiquitous use of physical browsing is presented and the feasibility is demonstrated with four concrete examples.
Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease (2019)

The medicinal chemistry and structure-activity relationships (SAR) for a novel series of carbamoyl pyridone bicycle (CAB) compounds as influenza Cap-dependent endonuclease (CEN) inhibitors are disclosed. Substituent effects were evaluated at the C (N)-1, N-3, and C-7 positions of the CAB ring system using a docking study. Submicromolar EC<sub>50</sub> values were achieved in the cellular assay with C-7-unsubstituted CAB which possessed a benzhydryl group on either the C-1 or the N-1 position. An N-3 substituent was found to be critical for the plasma protein binding effect in vitro, and the CAB-N analogue <b>2v</b> exhibited reasonable total clearance (CL<sub>tot</sub>). More importantly, compound <b>2v</b> displayed significant efficacy in a mouse model infected with influenza viruses.
Form, Function, and Regulation of ARGONAUTE Proteins (2010)

Both transcriptional (TGS) and posttranscriptional gene silencing (PTGS) are conserved eukaryotic gene regulatory mechanisms, integral for taming exogenous (viruses and bacteria) or endogenous (repetitive elements and transposons) invasive nucleic acids to minimize their impact on genome integrity and function. TGS and PTGS also are essential for controlling the expression of protein coding genes throughout development or in response to environmental stimuli. In plants and animals, at least one member of the conserved ARGONAUTE (AGO) protein family comprises the catalytic engine of the silencing complex, which is guided by sequence-specific small RNA to cognate RNA. In this review, we present general features of plant and animal AGO proteins and detail our knowledge on the 10 Arabidopsis thaliana AGOs.
Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis (2001)

Bunyamwera virus (family Bunyaviridae, genus Bunyavirus) contains a tripartite negative-sense RNA genome. The smallest RNA segment, S, encodes the nucleocapsid protein N and a nonstructural protein, NSs, in overlapping reading frames. We have generated a mutant virus lacking NSs, called BUNdelNSs, by reverse genetics. Compared with the wild-type (wt) virus, BUNdelNSs exhibited a smaller plaque size and generated titers of virus approximately 1 log lower. In mammalian cells, the mutant expressed greatly increased levels of N protein; significantly, the marked inhibition of host cell protein synthesis shown by wt virus was considerably impaired by BUNdelNSs. When inoculated by the intracerebral route BUNdelNSs killed BALB/c mice with a slower time course than wt and exhibited a reduced cell-to-cell spread, and titers of virus in the brain were lower. In addition, the abrogation of NSs expression changed Bunyamwera virus from a noninducer to an inducer of an interferon-beta promoter. These results suggest that, although not essential for growth in tissue culture or in mice, the bunyavirus NSs protein has several functions in the virus life cycle and contributes to viral pathogenesis.
Direction of Chromosome Rearrangements in <i>Saccharomyces cerevisiae</i> by Use of <i>his3</i> Recombinational Substrates (1988)

We used the his3 recombinational substrates (his3 fragments) to direct large interchromosomal (translocations) and intrachromosomal (deletions and tandem duplications) rearrangements in the yeast Saccharomyces cerevisiae. In strains completely deleted for the wild-type HIS3 gene, his3 fragments, one containing a deletion of 5' amino acid coding sequences and the other containing a deletion of 3' amino acid coding sequences, were first placed at preselected sites by homologous recombination. His+ revertants that arose via spontaneous mitotic recombination between the two his3 fragments were selected. This strategy was used to direct rearrangements in both RAD52+ and rad52 mutant strains. Translocations occurred in the RAD52+ genetic background and were characterized by orthogonal field alternating gel electrophoresis of yeast chromosomal DNA and by standard genetic techniques. An unexpected translocation was also identified in which HIS3 sequences were amplified. Two types of tandem duplications of the GAL(7, 10, 1) locus were also directed, and one type was not observed in rad52 mutants. Recombination mechanisms are discussed to account for these differences.
Sequence analysis of hepatitis A virus cDNA coding for capsid proteins and RNA polymerase. (1985)

We report here the nucleotide sequence corresponding to two large regions of the hepatitis A virus (HAV) genome. These comprise a sequence of 3274 bases corresponding to the 5' end of the genome, which includes the putative capsid protein region of this picornavirus, and 1590 bases corresponding to the 3' end of the genome, terminating in a 15-base poly(A) tract. These sequences revealed that HAV had the characteristic genomic organization of picornaviruses: an open reading frame beginning approximately 750 bases from the 5' end of the RNA and a termination codon 60 bases from the 3' poly(A) tract. The predicted amino acid sequences of both regions have been compared to analogous regions previously determined for other picornaviruses. There was sufficient homology to conclude that the 5' region of HAV codes for capsid proteins and that the 3' region codes for an RNA polymerase. However, these regions of HAV were not found to be closely related to analogous regions of poliovirus, encephalomyocarditis virus, and foot and mouth disease virus.