gebhart/patrepeval huggingface dataset:
Role of NAD(P)H Oxidase in Angiotensin II–Induced JAK/STAT Signaling and Cytokine Induction (2000)

Inflammatory processes involve both synthesis of inflammatory cytokines, such as interleukin-6 (IL-6), and the activation of their distinct signaling pathways, eg, the janus kinases (JAKs) and signal transducers and activators of transcription (STAT). Superoxide (O(2)(-)) anions activate this signaling cascade, and the vasoconstrictor angiotensin II (Ang II) enhances the formation of O(2)(-) anions via the NAD(P)H oxidase system in rat aortic smooth muscle cells. Ang II activates the JAK/STAT cascade via its type 1 (AT(1)) receptor and induces synthesis and release of IL-6. Therefore, we investigated the role of O(2)(-) anions generated by the NAD(P)H oxidase system on the Ang II activation of the JAK/STAT cascade and its impact on IL-6 synthesis. Ang II stimulation of rat aortic smooth muscle cells induced a rapid increase in O(2)(-) anions determined by laser fluoroscopy, which can be abolished by DPI, a flavoprotein inhibitor. Ang II-induced phosphorylation of JAK2, STAT1alpha/ss, STAT3, and IL-6-synthesis can be abolished by DPI, as determined by immunoprecipitations and Northern blot analysis. Electroporation of neutralizing antisera targeted against p47(phox), a NAD(P)H oxidase subunit, abolished Ang II-induced JAK/STAT activation and IL-6 synthesis. Inhibition of JAK2 by its inhibitor AG490 (10 micromol/L) blocked not only JAK2 activation but also IL-6 synthesis. These results suggest that stimulation of the JAK/STAT cascade by Ang II requires O(2)(-) anions generated by the NAD(P)H oxidase system, and O(2)(-) anion-dependent activation of the JAK/STAT cascade seems to be additionally involved in Ang II-induced IL-6 synthesis. Thus, Ang II-induced inflammatory effects seem to require O(2)(-) anions generated by the NAD(P)H oxidase system.
Point of interest recommendation with social and geographical influence (2016)

Point of interest (POI) recommendation, a service which can help people discover useful and interesting locations has emerged rapidly with the development of location-based social networks (LBSNs), like Foursquare, Gowalla and Wechat. The large number of check-in histories make it possible to mine the preference of each user and then to provide accurate personalized POI recommendation. In real-world applications, apart from check-in data, there are some other useful information available for making better POI recommendation, such as social relationship among users and geographical influence. In this paper, a new POI recommendation method called Social and Geographical Fusing Model (SGFM) is designed. The basic idea is summarized as follows. Firstly, the users' check-in records and social influence are integrated in a combinative model. Then the global user impact factors generated by the PageRank algorithm are used to improve the combinative model. Secondly, a geographical influence measurement is used to capture the users' physical check-in characters. Finally, the enhanced combinative model and geographical influence are combined together to form a new framework. Extensive experiments have been conducted on a famous dataset, namely Gowalla. The comparison results confirm that the proposed framework outperforms state-of-the-art POI recommendation methods significantly.
Proposal of Two New Species in the Genus Microbacterium: Microbacterium dextranolyticum sp. nov. and Microbacterium aurum sp. nov. (1993)

The taxonomic positions of Flavobacterium sp. strain IFO 14592T (= M-73T) (T = type strain), a dextran-α-1,2-debranching enzyme producer, and Microbacterium sp. strain IFO 15204T (= H-5T), an isolate obtained from corn steep liquor, were investigated; on the basis of the results of chemotaxonomic and phenetic studies and DNA-DNA similarity data, we propose that these bacteria should be classified in the genus Microbacterium as Microbacterium dextranolyticum sp. nov. and Microbacterium aurum sp. nov., respectively. The type strain of M. dextranolyticum is strain IFO 14592, and the type strain of M. aurum is strain IFO 15204.
Hybrid watermilfoil lineages are more invasive and less sensitive to a commonly used herbicide than their exotic parent (<scp>E</scp>urasian watermilfoil) (2012)

Hybridization may stimulate the evolution of invasiveness in human-impacted habitats if unique hybrid genotypes have higher fitness than parental genotypes. Human efforts to control invasive taxa frequently involve the intentional alteration of habitats, but few studies have considered whether hybridization can result in decreased sensitivity to control measures. Here, we investigate whether interspecific hybrids between introduced Eurasian watermilfoil (Myriophyllum spicatum) and native northern watermilfoil (M. sibiricum) are more invasive than parental Eurasian watermilfoil, especially in regard to their relative responses to an herbicide commonly applied for their control (2,4-dichlorophenoxyacetic acid; 2,4-D). In two separate laboratory experiments, hybrids on average grew faster and were less sensitive to 2,4-D compared with parental Eurasian watermilfoil. These two invasive traits appear to be common in hybrid watermilfoils, as opposed to being restricted to a few unique lineages, because they were found in a diversity of hybrid genotypes from several independent hybridization events. In addition, we found that hybrids occurred more frequently than parental species in natural lakes previously treated with 2,4-D. Our results provide compelling empirical evidence that hybridization is associated with the evolution of increased invasiveness in watermilfoils, and have important implications for their management.
Protease interactions with <i>Bacillus thuringiensis</i> insecticidal toxins (1999)

The microbe Bacillus thuringiensis (Bt) produces crystals that contain insecticidal crystal proteins (ICPs) used to control many major pests. ICPs are degraded by proteases from a variety of sources, including those endogenous to the bacterium, those purified from animals and plants, or those found in insects. Proteases in the bacterium function in protein metabolism during sporulation; in some cases they hydrolyze ICPs. Insect proteases are implicated in Bt toxin specificity, mode of action and insect adaptation to Bt. This review describes the current knowledge of protease interactions with ICPs with special emphasis on the role of proteases in insect resistance to Bt toxins. Arch. Copyright 1999 Wiley-Liss, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America.
Graphene Photonics, Plasmonics, and Optoelectronics (2013)

We review the characteristics of the optical excitations of graphene involving interband, intraband, and collective (plasmon) electronic excitations. We then discuss the different mechanisms by which photon energy can be converted to an electrical current in graphene. Finally, we review applications of graphene as transparent conductive screens, as photodetectors and light modulators at different wavelength ranges.
High-Throughput Random Access via Codes on Graphs (2010)

Recently, contention resolution diversity slotted ALOHA (CRDSA) has been introduced as a simple but effective improvement to slotted ALOHA. It relies on MAC burst repetitions and on interference cancellation to increase the normalized throughput of a classic slotted ALOHA access scheme. CRDSA allows achieving a larger throughput than slotted ALOHA, at the price of an increased average transmitted power. A way to trade-off the increment of the average transmitted power and the improvement of the throughput is presented in this paper. Specifically, it is proposed to divide each MAC burst in k sub-bursts, and to encode them via a (n,k) erasure correcting code. The n encoded sub-bursts are transmitted over the MAC channel, according to specific time/frequency-hopping patterns. Whenever n-e>=k sub-bursts (of the same burst) are received without collisions, erasure decoding allows recovering the remaining e sub-bursts (which were lost due to collisions). An interference cancellation process can then take place, removing in e slots the interference caused by the e recovered sub-bursts, possibly allowing the correct decoding of sub-bursts related to other bursts. The process is thus iterated as for the CRDSA case.
Smart Chair for Monitoring of Sitting Behavior (2017)

<p class="1">Sitting is a common behavior of human body in daily life. It is found that poor sitting postures can link to pains and other complications for people in literature. In order to avoid the adverse effects of poor sitting behavior, we have developed a highly practical design of smart chair system in this paper, which is able to monitor the sitting behavior of human body accurately and non-invasively. The pressure patterns of eight standardized sitting postures of human subjects were acquired and transmitted to the computer for the automatic sitting posture recognition with the application of artificial neural network classifier. The experimental results showed that it can recognize eight sitting postures of human subjects with high accuracy. The sitting posture monitoring in the developed smart chair system can help or promote people to achieve and maintain healthy sitting behavior, and prevent or reduce the chronic disease caused by poor sitting behavior. These promising results suggested that the presented system is feasible for sitting behavior monitoring, which can find applications in many areas including healthcare services, human-computer interactions and intelligent environment.</p>
All-optical multiwavelength clock recovery usingintegrated semiconductor amplifier array module (2001)

Simultaneous all-optical clock-recovery of WDM channels at 10 Gbit/s is demonstrated in an actively-modelocked fibre ring laser configuration using a novel 22-channel semiconductor optical amplifier array module integrated with two waveguide grating routers. The technique is based on using adjacent free-spectral ranges for the incoming data and recovered clock.
The First Zagreb and Randić Indices in Random Spiro Chains (2020)

The Randić (R) and first Zagreb (M1) are two important topological indices and located that useful tools in QSPR and QSAR investigations. During this paper, we’ll establish simple formulae for the values of Randić and first Zagreb indices of random spiro chains and present the average of them. Moreover, we comparisons between this of values for two topological indices of random spiro chains.
Design and implementation of a modulator-based free-space optical backplane for multiprocessor applications (2003)

Design and implementation of a free-space optical backplane for multiprocessor applications is presented. The system is designed to interconnect four multiprocessor nodes that communicate by using multiplexed 32-bit packets. Each multiprocessor node is electrically connected to an optoelectronic VLSI chip which implements the hyperplane interconnection architecture. The chips each contain 256 optical transmitters (implemented as dual-rail multiple quantum-well modulators) and 256 optical receivers. A rigid free-space microoptical interconnection system that interconnects the transceiver chips in a 512-channel unidirectional ring is implemented. Full design, implementation, and operational details are provided.
Enhanced Radiation-Induced Cell Killing and Prolongation of γH2AX Foci Expression by the Histone Deacetylase Inhibitor MS-275 (2004)

Histone deacetylase (HDAC) inhibitors are undergoing clinical evaluation for cancer therapy. Because HDAC modulates chromatin structure and gene expression, parameters considered to influence radioresponse, we have investigated the effects of the HDAC inhibitor MS-275 on the radiosensitivity of two human tumor cell lines (DU145 prostate carcinoma and U251 glioma). Acetylation status of histones H3 and H4 was determined as a function of time after MS-275 addition to and removal from culture medium. Histone acetylation increased by 6 h after MS-275 addition, reaching a maximum between 24 and 48 h of exposure; providing fresh drug-free medium then resulted in a decrease in histone acetylation that began by 6 h and approached untreated levels by 16 h. Treatment of cells with MS-275 for 48 h followed by irradiation had little or no effect on radiation-induced cell death. However, exposure to MS-275 before and after irradiation resulted in an increase in radiosensitivity with dose enhancement factors of 1.9 and 1.3 for DU145 and U251 cells, respectively. This MS-275 treatment protocol did not result in a redistribution of the cells into a more radiosensitive phase of the cell cycle or in an increase in apoptosis. However, MS-275 did modify the time course of gammaH2AX expression in irradiated cells. Whereas there was no significant difference in radiation-induced gammaH2AX foci at 6 h, the number of cells expressing gammaH2AX foci was significantly greater in the MS-275-treated cells at 24 h after irradiation. These results indicate that MS-275 can enhance radiosensitivity and suggest that this effect may involve an inhibition of DNA repair.
Consistency-based Semi-supervised Learning for Object detection (2019)

Making a precise annotation in a large dataset is crucial to the performance of object detection. While the object detection task requires a huge number of annotated samples to guarantee its performance, placing bounding boxes for every object in each sample is time-consuming and costs a lot. To alleviate this problem, we propose a Consistency-based Semi-supervised learning method for object Detection (CSD), which is a way of using consistency constraints as a tool for enhancing detection performance by making full use of available unlabeled data. Specifically, the consistency constraint is applied not only for object classification but also for the localization. We also proposed Background Elimination (BE) to avoid the negative effect of the predominant backgrounds on the detection performance. We have evaluated the proposed CSD both in single-stage(2) and two-stage detectors(3) and the results show the effectiveness of our method.
NGH on FPSO - Slurry Process and Cost Estimate (1999)

Abstract A hydrate slurry process is being developed for capturing associated gas on FPSO's. Natural gas hydrate contains 180 Sm of gas per m3 solid hydrate. It is this property that makes hydrates attractive for storage and transport of natural gas. Hydrate mixed with crude oil and refrigerated to -10 C remains stable at atmospheric pressure, for practical purposes. A capital cost estimate for a FPSO-based hydrate slurry process was carried out for 1,440,000 Sm3 associated gas and 16,000 Sm3 crude oil. The marginal capital cost was 160 million US dollars (the hydrate process only). The cost estimate was expanded to a hydrate slurry chain consisting of FPSO-based production, shuttle tanker transport and land-based receiving teminal. The hydrate chain consts were compared to transporting natural gas by a subsea pipeline. It was argued that hydrate slurry technology should be used for distances greater than 220 km.
Pilot Testing of WRI'S Novel Mercury Control Technology by Pre-Combustion Thermal Treatment of Coal (2008)

The challenges to the coal-fired power industry continue to focus on the emission control technologies, such as mercury, and plant efficiency improvements. An alternate approach to post-combustion control of mercury, while improving plant efficiency deals with Western Research Institute's (WRI)'s patented pre-combustion mercury removal and coal upgrading technology. WRI was awarded under the DOE's Phase III Mercury program, to evaluate the effectiveness of WRI's novel thermal pretreatment process to achieve >50% mercury removal, and at costs of <$30,000/lb of Hg removed. WRI has teamed with Etaa Energy, Energy and Environmental Research Center (EERC), Foster Wheeler North America Corp. (FWNA), and Washington Division of URS (WD-URS), and with project co-sponsors including Electric Power Research Institute (EPRI), Southern Company, Basin Electric Power Cooperative (BEPC), Montana-Dakota Utilities (MDU), North Dakota Industrial Commission (NDIC), Detroit Edison (DTE), and SaskPower to undertake this evaluation. The technical objectives of the project were structured in two phases: Phase I--coal selection and characterization, and bench-and PDU-scale WRI process testing and; and Phase II--pilot-scale pc combustion testing, design of an integrated boiler commercial configuration, its impacts on the boiler performance and the economics of the technology related to market applications. This report covers the results of the Phase I testing. The conclusion of the Phase I testing was that the WRI process is a technically viable technology for (1) removing essentially all of the moisture from low rank coals, thereby raising the heating value of the coal by about 30% for subbituminous coals and up to 40% for lignite coals, and (2) for removing volatile trace mercury species (up to 89%) from the coal prior to combustion. The results established that the process meets the goals of DOE of removing <50% of the mercury from the coals by pre-combustion methods. As such, further testing, demonstration and economic analysis as described in the Phase II effort is warranted and should be pursued.
Improved Clearance during Treatment of HPV-Positive Head and Neck Cancer through mTOR Inhibition (2013)

Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) incidence is increasing at a near epidemic rate. We investigated whether the mammalian (or mechanistic) target of rapamycin (mTOR) inhibitor, rapamycin, can be used as a concurrent agent to standard-of-care cisplatin/radiation therapy (CRT) to attenuate tumor lactate production, thus enhancing CRT-induced immune-mediated clearance of this antigenic tumor type. A C57Bl/6-derived mouse oropharyngeal epithelial cell line retrovirally transduced with HPV type 16 E6/E7 and human squamous cell carcinoma cell lines were evaluated for their response to rapamycin in vitro with proliferation assays, Western blots, and lactate assays. Clonogenic assays and a preclinical mouse model were used to assess rapamycin as a concurrent agent to CRT. The potential of rapamycin to enhance immune response through lactate attenuation was assessed using quantitative tumor lactate bioluminescence and assessment of cell-mediated immunity using E6/E7-vaccinated mouse splenocytes. Rapamycin alone inhibited mTOR signaling of all cancer cell lines tested in vitro and in vivo. Furthermore, rapamycin administered alone significantly prolonged survival in vivo but did not result in any long-term cures. Given concurrently, CRT/rapamycin significantly enhanced direct cell killing in clonogenic assays and prolonged survival in immunocompromised mice. However, in immunocompetent mice, concurrent CRT/rapamycin increased long-term cures by 21%. Preliminary findings suggest that improved survival involves increased cell killing and enhanced immune-mediated clearance in part due to decreased lactate production. The results may provide rationale for the clinical evaluation of mTOR inhibitors concurrent with standard-of-care CRT for treatment of HPV-positive HNSCC.
Investigation of single sideband optical lithography using oblique incidence illumination (1992)

We propose a new method for enhancing the image contrast in oblique illumination lithography. In this article, we analyze the modulation transfer function to clarify the cause of poor contrast in oblique illumination systems. A unique optimization procedure is also proposed. It is carried out for the oblique illumination systems, including single sideband optical lithography. It is found that the contrast enhancing method and optimization can improve the resolution for annular source and four-point-type sources. These improvements open up the possibility of 0.25-μm resolution with i-line lithography.
Hg/sup +/ trapped ion standard performance with the superconducting cavity maser oscillator as LO (2003)

The frequency stability obtained with an ion-trap-based frequency standard where /sup 199/Hg/sup +/ ions are confined in a hybrid RF/DC linear trap is described. The 40.5-GHz clock transition is measured to be as narrow as 17 mHz representing a quality factor of 2.4*10/sup 12/. A hydrogen maser interrogation of a 37-mHz Hg/sup +/ resonance is used to measure 1*10/sup -15/ stability of the ion resonance at 10000-s averaging time. In another measurement the frequency of the superconducting cavity maser oscillator is steered to follow the Hg/sup +/ clock transition, again providing frequency stability of 1*10/sup -15/ at 10000-s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Associations between Dopamine D4 Receptor Gene Variation with Both Infidelity and Sexual Promiscuity (2010)

DRD4 VNTR genotype varies considerably within and among populations and has been subject to relatively recent, local selective pressures. Individual differences in sexual behavior are likely partially mediated by individual genetic variation in genes coding for motivation and reward in the brain. Conceptualizing these findings in terms of r/K selection theory suggests a mechanism for selective pressure for and against the 7R+ genotype that may explain the considerable global allelic variation for this polymorphism.
Through-Tubing Inflatable Intervention Tools and Techniques in a Subsea Well Environment (2006)

Abstract With the number of subsea wells increasing so has the requirement to be able to provide lower cost through-tubing live well intervention solutions to a number of well servicing problems. Through-tubing operations on subsea wells are routinely being conducted from a variety of vessels such as monohull or smaller semi-submersible vessels through to larger drilling based rig operations. Many times when performing said remedial or abandonment work on subsea wells the conditions can prove to be extremely challenging to both operator and service provider. Many of the older subsea wells have come to the operating company via a variety of mergers and/or acquisitions and may prove to have a limited history. Often the actual conditions and geometry of the wellbore can be unclear until the subsea well is actually re-entered. However, at this point, the intervention vessel is already on station and incurring daily costs to the operator. In this paper we are going to disseminate several case histories, highlighting the technical and economical advantages that have been achieved in subsea well interventions utilizing through-tubing inflatable intervention tools. Apart from the more recognizable feature of being able to be conveyed into the well on either electric wireline or coiled tubing allowing for live well intervention, the often less perceived advantage of the inflatable type packing element is in its ability to be able to be set in a broad range of both diameters and conditions. Having this ability allows for the operator to have on board the vessel the opportunity to cover many different types of scenarios that may be encountered. This philosophy can markedly reduce the amount of tools required on board to cover a multitude of operations minimizing logistical, storage and cost concerns. One of the presented case histories will highlight how a planned operation prior to load out to plug the completion tubular in order to repair a leaking flowline ended up with the same mobilized tool providing a barrier while being set in the actual subsea tree due to the tubing being found to be parted on entering the well.