gebhart/patrepeval huggingface dataset:
The Apoptosis Induced by Ceramide in the Endothelial Cell. (2003)

Purpose: To evaluate the effect of variable ceramides on the apoptosis of corneal endothelial cell and then, if ceramide induce the apoptosis in endothelial cells, via which pathway apoptosis occur. Methods: Corneal endothelial cells were isolated from fresh rabbit cornea and cultured. Cultured corneal endothelial cells were exposed to 10, 20, 40 and 80 M of ceramide type II, VI and phytoceramide type II, VI. And then, apoptosis was evaluated with Hoechst staining and flow cytometric analysis with Annexin V for evaluation of apoptotic response. Corneal endothelial cells were preincubated in various concentrations of CPP32-like protease inhibitor (Z-VAD-FMK(R)), specific caspase-8 inhibitor(IETD-CHO(R)) and specific caspase-9 inhibitor (Z-LEHD-FMK(R)), then treated with 20 M of 4 types of ceramide. 12 hours later, LDH assay was done. Cytochrome c immunostaining was done after exposure to 4 types of ceramide. Results: Shrinkage of cytoplasm, formation of apoptotic bodies, and nuclear fragmentation were observed on Hoechst staining. In flow cytometric analysis, early apoptotic responses were identified. Apoptotic response increased significantly at the concentration of 10M and more 12 hours later. CPP32-like protease inhibitor, caspase-8, 9 inhibitor reduced the LDH activity. Apoptotic endothelial cells induced by ceramide were stained with cytochrome c antibody. Conclusions: Ceramide induced apoptosis in cultured corneal endothelial cells. This apoptosis developed via caspase and mitochondrial pathway.
Determination of Organic Acids in Root Exudates by High Performance Liquid Chromatography: I. Development and Assessment of Chromatographic Conditions *1 (1998)

Methods for determining nine low molecular weight organic acids in root exudates were developed by using reversed phase high performance liquid chromatography with UV (ultraviolet) detection at 214 nm. The mobile phase was 18 mmol L -1 kH 2PO 4 adjusted to pH 2.25 with phosphoric acid and the flow rate was 0.3 mL min -1 . The analytical column was a reversed phase silica based C 18 column (Shim pack CLC ODS). The root exudates were collected through submerging the whole root system into aerated deionized water for 2 hours. The filtered exudate solutions were concentrated to dryness by rotary evaporation at 40 °C, dissolved in 10 mL mobile phase. The chromatographic conditions of organic acid determination were analyzed. The results showed that there was a high selectivity and sensitivity in the organic acid determination by reversed phase high performance liquid chromatography. Coefficients of variation for organic acid determination were lower than 10% except lactic acid. The recoveries were consistently between 80.1% to 108.3%. Detection limits were approximately 0.05 to 4.5 mg L -1 for organic acids except succinic acid with the detection limit of 7.0 mg L -1 . Phosphorus deficiency may contribute to the release of organic acids in soybean root exudates especially malic, lactic and citric acids.
Research and Implementation of Large-scale Context Management Framework Based on Terminal and Cloud (2013)

The context situation refers the global view extracted from massive context information collected from a wide area.Along with the popularity of various mobile terminals with the ability to sense its context,it is a great problem to get this kind of situation and provide better service based on what we get.On the basis of the terminal+cloud computing paradigm,this paper proposed a unified Abstract model for mobile terminals to realize context collections.And then,we proposed an algorithm to realize the aggregation of massive context information on the cloud side,which is based on the MapReduce computing pattern.We validated the research content of this paper by a large-scale context management framework as well as a traffic situation application based on this framework.
Fast and Efficient Fragment-Based Lead Generation by Fully Automated Processing and Analysis of Ligand-Observed NMR Binding Data (2016)

NMR binding assays are routinely applied in hit finding and validation during early stages of drug discovery, particularly for fragment-based lead generation. To this end, compound libraries are screened by ligand-observed NMR experiments such as STD, T1ρ, and CPMG to identify molecules interacting with a target. The analysis of a high number of complex spectra is performed largely manually and therefore represents a limiting step in hit generation campaigns. Here we report a novel integrated computational procedure that processes and analyzes ligand-observed proton and fluorine NMR binding data in a fully automated fashion. A performance evaluation comparing automated and manual analysis results on (19)F- and (1)H-detected data sets shows that the program delivers robust, high-confidence hit lists in a fraction of the time needed for manual analysis and greatly facilitates visual inspection of the associated NMR spectra. These features enable considerably higher throughput, the assessment of larger libraries, and shorter turn-around times.
Comparison of the crystal and molecular structures of cyclopentadienylbromodicarbonylruthenium(II) and (ethyltetramethylcyclopentadienyl)bromodicarbonylruthenium(II) (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of the crystal and molecular structures of cyclopentadienylbromodicarbonylruthenium(II) and (ethyltetramethylcyclopentadienyl)bromodicarbonylruthenium(II)Harry Adams, Neil A. Bailey, and Colin WhiteCite this: Inorg. Chem. 1983, 22, 8, 1155–1158Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://doi.org/10.1021/ic00150a002RIGHTS & PERMISSIONSArticle Views43Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (527 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Under CoVer (1994)

At GMD-IPSI we are developing CoVer, a contextual version server for hypertext applications. Another characterization of CoVer is that CoVer integrates state-oriented versioning concepts with task-oriented versioning concepts. While other version models in general support only one of these groups of concepts, we argue that the explicit composition of versions of complex hypertext networks has to be complemented by automatic version creation in the context of tasks or jobs performed while manipulating the hypertext network and vice versa. Regarding the implementation of version models, it turns out that the state-oriented implementation approach—representing every legal state of a hyperdocument explicitly—and the task-oriented implementation approach—computing versions of complex hypertext networks due to changes executed during a task or job—are interchangeable. While the separation of state- and task-oriented concepts at the conceptual level of the version model is desireable to support version creation and selection for different hypertext applications, the implementation of such a dual model can be based on a single implementation approach. This paper discusses both types of implementation with an emphasis to cope with alternative versions that are in particular meaningful for hypertext publishing applications.
Reinforcement learning techniques for Outer Loop Link Adaptation in 4G/5G systems (2017)

Wireless systems perform rate adaptation to transmit at highest possible instantaneous rates. Rate adaptation has been increasingly granular over generations of wireless systems. The base-station uses SINR and packet decode feedback called acknowledgement/no acknowledgement (ACK/NACK) to perform rate adaptation. SINR is used for rate anchoring called inner look adaptation and ACK/NACK is used for fine offset adjustments called Outer Loop Link Adaptation (OLLA). We cast the OLLA as a reinforcement learning problem of the class of Multi-Armed Bandits (MAB) where the different offset values are the arms of the bandit. In OLLA, as the offset values increase, the probability of packet error also increase, and every user equipment (UE) has a desired Block Error Rate (BLER) to meet certain Quality of Service (QoS) requirements. For this MAB we propose a binary search based algorithm which achieves a Probably Approximately Correct (PAC) solution making use of bounds from large deviation theory and confidence bounds. In addition to this we also discuss how a Thompson sampling or UCB based method will not help us meet the target objectives. Finally, simulation results are provided on an LTE system simulator and thereby prove the efficacy of our proposed algorithm.
SLAM of Robot based on the Fusion of Vision and LIDAR (2018)

The Simultaneous Localization and Mapping (SLAM) of robots plays an increasingly important role in the development of mobile robots. The two most commonly used methods are visual and LIDAR methods. In the visual design, the RGB-D camera is sensitive to light, and it has a narrow field of vision. Besides, in the featureless environment, it is difficult to extract visual features. The confines above lead to a poor tracking in practice, which causes a failure in mapping completely. This paper aims at the tracking part of SLAM using an RGB-D camera and 2d low-cost LIDAR to finish a robust indoor SLAM by a mode switch and data fusion. The experiment shows that our method can get an effect map even in the featureless environment.
Mesenchymal stem cells with overexpression of midkine enhance cell survival and attenuate cardiac dysfunction in a rat model of myocardial infarction (2014)

Therapies employing MSCs with MK overexpression may represent an effective treatment for improving cardiac dysfunction and survival rate after MI.
Dracaenoside A and B, new C-22 steroidal lactone glycosides from the stem of Dracaena cochinchinensis (2003)

Two new C-22 steroidal lactone glycosides, named dracaenoside A and B were isolated from the methanol extract of the fresh stem of Dracaena cochinchinensis. Their structures were established as (20S)3beta,14alpha,16beta-trihydroxy pregn-5-ene-22-carboxylic acid (22,16)-lactone 3-O-alpha-L-rhamnopyranosyl (1-->2)[ alpha-L-rhamnopyranosyl (1-->4)]-beta-D-glucopyranoside and (20S)3beta, 14alpha, 16beta-trihydroxy pregn-5-ene-22-carboxylic acid (22,16)-lactone 3-O-alpha-L-rhanmopyranosyl (1-->2) [beta-D-glucopyranosyl(1-->3)]-beta-D-glucopyranoside by means of 2D NMR spectral and chemical methods. It is the first time that steroidal lactone glycosides were isolated from the genus Dracaena.
Endothelialization of Novel Magnesium-Rare Earth Alloys with Fluoride and Collagen Coating (2014)

Magnesium (Mg) alloys are promising scaffolds for the next generation of cardiovascular stents because of their better biocompatibility and biodegradation compared to traditional metals. However, insufficient mechanical strength and high degradation rate are still the two main limitations for Mg materials. Hydrofluoric acid (HF) treatment and collagen coating were used in this research to improve the endothelialization of two rare earth-based Mg alloys. Results demonstrated that a nanoporous film structure of fluoride with thickness of ~20 µm was formed on the Mg material surface, which improved the corrosion resistance. Primary human coronary artery endothelial cells (HCAECs) had much better attachment, spreading, growth and proliferation (the process of endothelialization) on HF-treated Mg materials compared to bare- or collagen-coated ones.
Structural elucidation and independent synthesis of the radical-radical coupling products of 3-hydroxyanthranilic acid with tyrosine and phenols (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural elucidation and independent synthesis of the radical-radical coupling products of 3-hydroxyanthranilic acid with tyrosine and phenolsMichael K. Manthey, Stephen G. Pyne, and Roger J. W. TruscottCite this: J. Org. Chem. 1990, 55, 15, 4581–4585Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/jo00302a022https://doi.org/10.1021/jo00302a022research-articleACS PublicationsRequest reuse permissionsArticle Views505Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Food Allergies: A Complete Guide for Eating When Your Life Depends on It (2013)

Posing the questions that anyone with food allergies will think to ask - and then some - Food Allergies provides practical, emotional, and scientific guidance on the topics that affect your life. Allergy expert Scott H. Sicherer addresses the full spectrum of food allergies, from mild to life threatening, from single foods to food families, clearing up misconceptions along the way. He explains how exposure to foods can bring about an allergic response, describes the symptoms of food allergy, and illuminates how food allergies develop. He also recommends tests for diagnosing both food allergies and chronic health problems caused by food allergies - such as eczema, hives, and respiratory and gastrointestinal symptoms. Food Allergies thoroughly explains how to prevent exposure to a known allergen at home, at school, in restaurants, and elsewhere and what to do if exposure occurs, including how to handle an anaphylactic emergency. Dr. Sicherer also reviews food reactions that are not allergic (such as lactose intolerance), advises how to get adequate nutrition when you must avoid dietary staples, and discusses whether allergies ever go away (they do-and then sometimes they return).
Transforming growth factor-β1 down-regulates expression of chemokine stromal cell–derived factor-1: functional consequences in cell migration and adhesion (2003)

Chemokine stromal cell-derived factor-1 (SDF-1) is expressed by bone marrow (BM) stromal cells and plays key roles in BM cell migration. Modulation of its expression could affect the migratory capacity of cells trafficking the BM, such as hematopoietic progenitor and leukemic cells. Transforming growth factor-beta1 (TGF-beta1) is present in the BM environment and constitutes a pivotal molecule controlling BM cell proliferation and differentiation. We used the BM stromal cell line MS-5 as a model to investigate whether SDF-1 expression constitutes a target for TGF-beta1 regulation and its functional consequences. We show here that TGF-beta1 down-regulates SDF-1 expression, both at the mRNA level, involving a decrease in transcriptional efficiency, and at the protein level, as detected in lysates and supernatants from MS-5 cells. Reduction of SDF-1 in supernatants from TGF-beta1-treated MS-5 cells correlated with decreased, SDF-1-dependent, chemotactic, and transendothelial migratory responses of the BM model cell lines NCI-H929 and Mo7e compared with their responses to supernatants from untreated MS-5 cells. In addition, supernatants from TGF-beta1-exposed MS-5 cells had substantially lower efficiency in promoting integrin alpha4beta1-mediated adhesion of NCI-H929 and Mo7e cells to soluble vascular cell adhesion molecule-1 (sVCAM-1) and CS-1/fibronectin than their untreated counterparts. Moreover, human cord blood CD34+ hematopoietic progenitor cells displayed SDF-1-dependent reduced responses in chemotaxis, transendothelial migration, and up-regulation of adhesion to sVCAM-1 when supernatants from TGF-beta1-treated MS-5 cells were used compared with supernatants from untreated cells. These data indicate that TGF-beta1-controlled reduction in SDF-1 expression influences BM cell migration and adhesion, which could affect the motility of cells trafficking the bone marrow.
Use of allogenic epidermal sheets for difficult wound healing: Selection and testing of relevant growth factors (2006)

The clinical interest of using allogenic epidermal sheets (AES) has largely been shown [1,2,3]. As well as covering, they also stimulate healing, by simultaneously secreting numerous growth factors (GFs), although little is known on their mechanism of action. Our objectives were to: (a) devise a test for the efficacy of AES release, (b) select keratinocyte-secreting strains and optimal culture conditions. Three GFs were selected: IL-1alpha, IL-8 and VEGF. Three different keratinocyte strains were cultured for 3 and 6 days after confluence for 3 passages. Assays were performed after 3 h and 24 h+3 h after dispase treatment (AES conservation for 24 h then change of medium and sampling after 3 h). AES were found to secrete GFs in DMEM and the amounts were greater when cultured for 6 rather than 3 days after confluence. Each strain had different secretory patterns depending on passage and time in culture, this variability being explained by inter-individual heterogeneity.
Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells. (1993)

Estradiol stimulates protein phosphorylation on tyrosine in human breast cancer MCF-7 cells under conditions of estradiol-stimulated cell growth. The stimulatory effect of estradiol has been observed by 32P-labeling of cells followed by purification of proteins using antiphosphotyrosine antibody coupled to agarose and confirmed by immunoblotting analysis with antiphosphotyrosine antibody. This stimulation is immediate (maximal in 10 s) and transient. In addition, it is receptor-mediated since estradiol stimulation is prevented by two well-known antiestrogens, OH-Tamoxifen and ICI 164,384. Estradiol fails to stimulate tyrosine protein phosphorylation of Cos cells which do not express the estradiol receptor. Two substrates of the estrogen stimulated phosphorylation on tyrosine with approximate mol wt of 55 and 60 kDa interact with a polyclonal antibody raised against amino acids 527-533 of pp60c-src (anti-cst.1 antibody). Tyrosine kinase activity of immunoprecipitates made using either anti cst.1 antibody or the monoclonal 327 antibody specific for pp60c-src shows that kinase(s) strongly related to pp60c-src are immediately and transiently stimulated by estradiol treatment of cells. The present findings provide the first demonstration that a steroid hormone rapidly stimulates tyrosine phosphorylation of target cells and induces functional modifications of substrates of this phosphorylation. These modifications might initiate the estradiol action on cell growth.
Modal Energy Trending for Ringdown Analysis in Power Systems Using Synchrophasors (2014)

Accurate on-line estimation of power systems oscillatory modes is important for dealing with complex interactions of large interconnected power systems especially in light of growing number of wind farms with complex power electronics controls. This paper describes an automatic ringdown analysis algorithm for extracting dominant oscillatory modes in power system responses from multiple synchronized Phasor Measurement Unit (PMU) measurements. The proposed approach estimates the system modes by tracking and analyzing the trend of modal oscillation energy seen in the Power Spectrum Density (PSD) of the measured ringdown response. Singular Value Decomposition of Power Spectrum Density matrix as in Frequency Domain Decomposition (FDD) algorithm is used to get overall energy measures for each dominant mode from multiple PMU signals in the ringdown response. This method is useful for real-time oscillation detection and analysis. The combination of frequency domain analysis and SVD enable the method to be robust under noisy conditions. The method is tested with simulation data as well as real power system archived data, and is shown to accurately extract multiple oscillatory modes and their mode shapes from system measurements.
Efficient region search for object detection (2011)

We propose a branch-and-cut strategy for efficient region-based object detection. Given an oversegmented image, our method determines the subset of spatially contiguous regions whose collective features will maximize a classifier's score. We formulate the objective as an instance of the prize-collecting Steiner tree problem, and show that for a family of additive classifiers this enables fast search for the optimal object region via a branch-and-cut algorithm. Unlike existing branch-and-bounddetection methods designed for bounding boxes, our approach allows scoring of irregular shapes - which is especially critical for objects that do not conform to a rectangular window. We provide results on three challenging object detection datasets, and demonstrate the advantage of rapidly seeking best-scoring regions rather than subwindow rectangles.
Gold and iodine diffusion in large area perovskite solar cells under illumination (2017)

Operational stability is the main issue hindering the commercialisation of perovskite solar cells. Here, a long term light soaking test was performed on large area hybrid halide perovskite solar cells to investigate the morphological and chemical changes associated with the degradation of photovoltaic performance occurring within the devices. Using Scanning Transmission Electron Microscopy (STEM) in conjunction with EDX analysis on device cross sections, we observe the formation of gold clusters in the perovskite active layer as well as in the TiO2 mesoporous layer, and a severe degradation of the perovskite due to iodine migration into the hole transporter. All these phenomena are associated with a drastic drop of all the photovoltaic parameters. The use of advanced electron microscopy techniques and data processing provides new insights on the degradation pathways, directly correlating the nanoscale structure and chemistry to the macroscopic properties of hybrid perovskite devices.