gebhart/patrepeval huggingface dataset:
[Delayed cerebral dysautoregulation after recirculation of cerebral ischemia]. (1993)

Sequential changes of cerebral autoregulation were studied in 20 cats after recirculation of cerebral ischemia. The cerebral autoregulation was evaluated by autoregulation index (A.I.), calculating % delta cerebral blood flow (CBF)/delta cerebral perfusion pressure (CPP), with changing the mean arterial blood pressure (MABP) within 80-130 mmHg. Duration of ischemic insult was 15 min after disappearance of direct cortical response (DCR). Following recovery of cerebral circulation, MABP, CBF and intracranial pressure (ICP) were observed sequentially for at least 48 hours. In 6 of 20 cats the autoregulation was disturbed early after recirculation, and the ICP was increased, resulting in no cerebral blood flow (early deteriorated group). In the other 14 cats the autoregulation was restored immediately, but in 7 of the 14 cats it was disturbed again after 24 hours following recirculation (delayed deteriorated group), finally the ICP was elevated and the CBF became 0 as same as early deteriorated group. In another 7 cats it was not disturbed until 5 days. The changes in CBF following insult were five patterns. These were classified into type A (Gradual decrease), type B (Transient increase), type C (Constant maintenance), type D (Relatively rapid decrease) and type E (Rapid decrease). The delayed cerebral dysautoregulation occurred in the types except for type A and type E. These results suggested there was close relation between delayed dysautoregulation and delayed neuronal dysfunction that we reported previously. Moreover, we considered the delayed dysautoregulation could be speculated from the value of ICP/CBF immediately after recirculation and the pattern of the changes in CBF during ischemic insult.
Inhibition of complement-mediated opsonization and phagocytosis of Streptococcus pyogenes by D fragments of fibrinogen and fibrin bound to cell surface M protein. (1985)

The biological effects of the binding of fibrin(ogen) degradation products to M protein-bearing group A streptococci were investigated. Type 24 group A streptococci bind fibrinogen degradation products of the D family, but not fragment E. Binding appears to be mediated by M protein, since a large peptide of this molecule (pep M24) bound to fragments containing the terminal domains of the fibrinogen molecule (D, X, and Y), but not fragment E, and pep M24 inhibited the binding of digested fibrinogen to streptococcal cells. An M protein-binding site occurs on fragment D3 and, therefore, differs from several functional sites present on D1 but not D3, including the fibrin polymerization site, the two gamma chain crosslink sites, and the bindings sites for platelet fibrinogen receptor, staphylococcal clumping factor, and ionized calcium. Bound fibrinogen degradation products prevented deposition of C3 on the streptococcal cell surface, and, in consequence, prevented phagocytosis by neutrophils in nonimmune blood. The average affinity of D fragments for the streptococcal cell surface was approximately 30 times lower than that of native fibrinogen, and a terminal plasmic digest was approximately 50 times less potent in inhibiting opsonization by C3. However, physiologic concentrations of digested fibrinogen sufficed to inhibit opsonization and phagocytosis completely. Digests of crosslinked fibrin clot also inhibited opsonization, although slightly less effectively than did fibrinogen digests. The antiopsonic effect of fibrin(ogen) degradation products may be relevant to circumstances in which fibrin(ogen)olysis is occurring, e.g., exudation and suppuration.
A Methodology for Optimization in Multistage Industrial Processes: A Pilot Study (2015)

The paper introduces a methodology for optimization in multistage industrial processes with multiple quality criteria. Two ways of formulation of optimization problem and four different approaches to solve the problem are considered. Proposed methodologies were tested first on a virtual process described by benchmark functions and next were applied in optimization of multistage lead refining process.
Pathology of premalignant colorectal neoplasia (2016)

Colorectal cancer is a heterogeneous oncological disease that develops through several molecular pathways. Each pathway is associated with specific neoplastic precursor lesions. Classification of colorectal polyps and the molecular features of associated colorectal cancers have undergone significant changes. An understanding of colorectal carcinogenesis and the molecular features of colorectal carcinomas is now regarded as necessary for personalized treatment and management of patients with colon cancer, and even for patients undergoing screening colonoscopy for early detection and prevention of colorectal cancer. In the present review, we describe the pathological and molecular features of epithelial precursor lesions involved in the early phases of colorectal carcinogenesis.
Noncollinear parametric amplification in the near-infrared based on type-II phase matching (2015)

Noncollinear parametric amplification based on type-II phase matching for the generation of ultrabroadband and tunable spectra in the near infrared is investigated. In a noncollinear geometry the group velocity matching condition between signal and idler can be obtained in frequently used crystals such as β-barium borate (BBO) even for wavelengths fully located in the anomalous dispersion region. The extremely broadband operation, peculiar tuning possibilities and straightforward experimental implementation with the standard BBO crystal pave the way for a versatile NIR source in ultrafast spectroscopy.
Pharmacological evidence for a single bradykinin B<sub>2</sub> receptor in the guinea‐pig (1995)

1. The present study addresses the possibility of the existence of different kinin B2 receptor subtypes in the guinea-pig by evaluating the affinity of peptide and nonpeptide receptor antagonists. For this purpose, jugular vein rings, ileum segments, lung parenchymal and trachea strips were set up in organ baths for isometric tension measurements. The experiments were conducted in the presence o indomethacin (3 microM), atropine (10 microM) and captopril (10 microM). 2. BK contracted jugular vein (JV), ileum (GPI), parenchyma (LP) and trachea (GPT) with an EC50 of 13.2 +/- 1.4 nM (n=27), 11.2 +/- 2.1 (n=26), 23.6 +/- 6.3 (n=26), and 33.0 +/- 6.5 (n=27), respectively. Thiorphan, a neutral endopeptidase (EC 3.4.34.11) inhibitor and MERGETPA (DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid), a carboxypeptidase inhibitor, had no effect on the BK-induced contractions of JV, GPI and LP. In the GPT, thiorpan potentiated the contractile response to BK and was thus added in the corresponding experiments. 3. The peptide B2 receptor antagonist, Hoe 140 and the nonpeptide compound, WIN 64338, behaved as noncompetitive antagonists against contractile responses to cumulative BK in the four tissues although Hoe 140 appeared as a competitive inhibitor in the GPT only. IN order to compare the inhibitory potency of these compounds between tissues, pKB values were determined. Mean values of pKB for Hoe 140 were 8.05 +/- 0.07, 8.43 +/- 0.11, 8.13 +/- 0.18, and 8.52 +/- 0. 25 in the JV, GPI, GPT and LP, respectively. WIN 64338 gave mean pKB values of 6.89 +/- 0.10, 7.57 +/- 0.12, 7.36 +/- 0.12 adn 7.51 +/- 0.28 in the JV, GPI, LP and GPT, respectively. 4. D-Arg [Hyp3, D-Phe7, Leu8]BK and D-Arg[Hyp3, D-Phe7]BK (NPC 567) inhibited in a competitive fashion the concentration-response curves to BK. Values of pA2for each compound were not significantly different in the four tissues and were between 5.81 and 6.31 for D-Arg [Hyp3, D-Phe7, Leu8]BK and between 5.55 and 5.65 for NPC 567.
Adaptive closed-loop power control with quantized feedback and loop filtering (2002)

Power control is important in maintaining the communication link quality under fading and interference situations. In previous years, research on power control has been conducted towards reducing the power consumption while maintaining reliable link quality. These previous works, however, did not try to optimize the power control algorithms under practical constraints. In this paper, we first provide a critical review of the previous works on different aspects of power control schemes. We then propose a new power control scheme which has several novel features: it uses an adaptive optimal quantizer at the receiver for transmitting discrete feedback information and an adaptive quantization scaler/restorer followed by a loop filter at the transmitter. Intuitive explanation of the effectiveness of the proposed design is provided. Analysis and simulation results are also given.
Research of effect on distribution network with penetration of photovoltaic system (2010)

The effect on distribution network with penetration of photovoltaic system is studied. Firstly, the effect to distribution network's power flow is studied when photovoltaic power is connected to distribution network. The bus voltages are calculated when the power factor cosϕ of the photovoltaic power varies from −0.95 (absorbing reactive power) to +0.95 (developing reactive power) and photovoltaic power varies from 0MW to 1.5MW. Then the effect to distribution network's voltage is studied when photovoltaic power is connected to distribution network. The voltage of the node connecting PV power with grid is adjusted by adjusting photovoltaic power factor, regulating step-up transformer ratio and switching reactive power compensation device of step-up substation. Finally, the effect of photovoltaic power on relay protection in distribution network is studied. The effects of photovoltaic power on short-circuit current and relay protection are different when the location and the capacity of photovoltaic power are different. The photovoltaic power is in the upstream, the downstream and the interior of relay protection according to the relative position of photovoltaic power and relay protection. The simulation has carried out respectively according to different locations.
Query Expansion for Document Retrieval by Mining Additional Query Terms (2005)

In this paper, we present a new query expansion method for document retrieval by mining additional query terms. The proposed query expansion method uses the vector space model to represent documents and queries. It uses the degrees of importance of relevant terms for finding additional query terms and uses fuzzy rules to infer the weights of the additional query terms. Then, these additional query terms and the original query terms are used to retrieve documents for improving the performance of information retrieval systems. The proposed query expansion method increases the precision rates and the recall rates of information retrieval systems for dealing with document retrieval.
Contamination of nanoparticles by endotoxin: evaluation of different test methods (2012)

We demonstrated that nanoparticles can interfere with endotoxin detection systems indicating that a convenient test method must be chosen before assessing endotoxin contamination in nanoparticle samples.
Hybrid Duplex Wireless Peer Discovery With Imperfect Self-Interference Cancellation (2017)

This letter investigates the hybrid duplex wireless peer discovery (Hyb-WPD) that increases the average number of discovered peers (ADP), through arbitrating between half duplex and full duplex (FD) operations. FD allowing simultaneous transceiving inherently introduces residual self-interference (RSI) due to non-ideal implementation; thus, this impairment yields a new design issue for transmission probability, which determines whether a peer receives or transceives. This letter proposes the design principles for the Hyb-WPD depending on RSI through mathematically analyzing the ADP, and the numerical results demonstrate their performance.
Spred-1 Negatively Regulates Interleukin-3-mediated ERK/Mitogen-activated Protein (MAP) Kinase Activation in Hematopoietic Cells (2004)

Sprouty/Spred family proteins have been identified as negative regulators of growth factor-induced ERK/mitogen-activated protein (MAP) kinase activation. However, it has not been clarified whether these proteins regulate cytokine-induced ERK activity. We found that Spred-1 is highly expressed in interleukin-3 (IL-3)-dependent hematopoietic cell lines and bone marrow-derived mast cells. To investigate the roles of Spred-1 in hematopoiesis, we expressed wild-type Spred-1 and a dominant negative form of Spred-1, DeltaC-Spred, in IL-3- and stem cell factor (SCF)-dependent cell lines as well as hematopoietic progenitor cells from mouse bone marrow by retrovirus gene transfer. In IL-3-dependent Ba/F3 cells expressing c-kit, forced expression of Spred-1 resulted in a reduced proliferation rate and ERK activation in response to not only SCF but also IL-3. In contrast, DeltaC-Spred augmented IL-3-induced cell proliferation and ERK activation. Wild-type Spred-1 inhibited colony formation of bone marrow cells in the presence of cytokines, whereas DeltaC-Spred-1 expression enhanced colony formation. Augmentation of ERK activation and proliferation in response to IL-3 was also observed in Spred-1-deficient bone marrow-derived mast cells. These data suggest that Spred-1 negatively regulates hematopoiesis by suppressing not only SCF-induced but also IL-3-induced ERK activation.
Current Guidelines for the Treatment of Severe Pneumonia and Sepsis (2005)

Appropriate beta-lactam antibiotics recommended in international and German guidelines for the treatment of severe CAP, NP and septicemia, either as monotherapy or as combination therapy, are the 4th generation cephalosporin cefepime, the carbapenems imipenem and meropenem, and the acylamino-beta-lactamase inhibitor combination piperacillin-tazobactam.
ATM adaptation layer 2 (AAL2) for low bit rate speech and data: issues and challenges (2002)

A new ATM adaptation layer (AAL2) to support low bit rate and delay sensitive applications in an ATM environment has been approved by ITU-T. AAL2 allows multiplexing of voice/data packets (minicells) from different users in a single ATM connection thus improving the utilization of the network resources. This paper identifies issues related to AAL2 such as the application environment, the gain obtained by multiplexing voice packets from different users on a single ATM connection, buffer requirements and cell assembly delay. To analyze these issues, we modeled and simulated ATM trunking between a base transceiver station (BTS) and the mobile switching center (MSG). The performance simulations show that the multiplexing gain obtained by AAL2 is significant and the output buffer requirement at the ATM node is small. In addition, AAL2 level packet switching and the current activities on AAL2 signaling are described.
40-W CW broad-band spatial power combiner using dense finline arrays (1999)

This paper presents a broad-band spatial power-combining system based on tapered-slot antenna arrays integrated in a standard WR-90 waveguide environment. The system is designed using a modular tray architecture, providing full waveguide-band frequency coverage and an excellent thermal environment for a set of monolithic-microwave integrated-circuit (MMIC) amplifiers. The shape of the tapered-slot or finline structures was optimized to minimize return loss and provide a broad-band impedance transformation from the waveguide mode to the MMIC amplifiers. A prototype eight-element array using commercial GaAs MMIC power amplifiers yielded a maximum of 41 W output power (continuous wave) with a gain variation less than /spl plusmn/1.2 dB within the entire band of interest. The average combining efficiency over the operating band was estimated at 73%. The results suggest the efficacy of the design and a strong potential for higher powers by moving toward a greater number of MMIC's per tray and a larger number of trays. Should the 100 W system be realized in the near future, our combiner system will become a promising candidate to challenge the dominant position currently claimed by the traveling-wave tube amplifiers.
Inner Ear Therapeutics: An Overview of Middle Ear Delivery (2019)

There are a variety of methods to access the inner ear and many of these methods depend on utilizing the middle ear as a portal. In this approach the middle ear can be used as a passive receptacle, as part of an active drug delivery system, or simply as the most convenient way to access the inner ear directly in human subjects. The purpose of this volume is to examine some of the more cutting-edge approaches to treating the middle ear. Before considering these therapies, this manuscript provides an overview of some therapies that have been delivered through the middle ear both in the past and at the current time. This manuscript also serves as a review of many of the methods for accessing the inner ear that directly utilize or pass though the middle ear. This manuscript provides the reader a basis for understanding middle ear delivery, the basis of delivery of medicines via cochlear implants, and examines the novel approach of using hypothermia as a method of altering the responses of the inner ear to damage.
성남지역 대학생 건강검진에서 대사증후군의 유병율 및 영양상태의 관련성 연구 (2011)

Some papers have raised a lot of concerns about relation among the prevalence of metabolic syndrome, serum ferritin and metabolic syndrome.
 ...
High performance cobalt-free perovskite cathode for intermediate temperature solid oxide fuel cells (2010)

Bi doping of SrFeO3−δ results in the formation of a structure with high symmetry and extraordinary electrochemical performance for Bi0.5Sr0.5FeO3-δ, which is capable of competing effectively with the current Co-based cathode benchmark with additional advantages of lower thermal expansion and cost.
Experimental generation and quantification of stator core faults on induction motors (2009)

A non-destructive method to analyze stator core faults on induction motors is presented and developed in the present work. It allows generating entirely reversible faults of different magnitudes. The quantification of fault severity was performed through the stator core interlaminar insulation test and through no-load test. The obtained experimental results show the feasibility of the method and the detectability of generated faults, which makes it a useful method to develop new diagnosis strategies.
A 9-bit 215 MS/s Folding-Flash Time-to-Digital Converter Based on Redundant Remainder Number System in 45-nm CMOS (2018)

The first folding-flash time-to-digital converter (TDC) based on the remainder number system (RNS) is reported. In this paper, fine quantization of an input time interval is performed directly with dual free-running ring oscillators without additional circuitry to record the coarse bits. The RNS architecture reduces hardware complexity significantly without speed impairment relative to the full flash counterpart employing delay chains. As a proof-of-concept design, 490 quantization levels using only 84 delay stages achieve a sample rate of 215 MS/s and an LSB size of 9.4 ps. Without trimming or calibration, the measured differential nonlinearity and integral nonlinearity of the RNS TDC prototype are +0.53/-0.57 and +1.1/-1.1 LSBs, respectively.
"The Violence of Place and Pen" Identities and Language in the Twentieth-Century Historiography of King Philip's War (2020)

This article traces the twentieth-century historiography of King Philip’s War, a destructive eleven-month conflict between New Englanders and their “Praying Indian” allies and a loose alliance of Southern Algonquians led by the Wampanoag sachem Metacom, or King Philip. Although widely impactful across New England, the war attracted little scholarly attention until the late 1950s, when historian Douglas E. Leach wrote Flintlock and Tomahawk. Leach’s book reignited the historical profession’s interest in the conflict and launched two significant and wide-ranging historiographic debates that are the subjects of this article. The first of these historiographic debates concerned the relationship between categories of identity, wartime alliances, and intercultural encounters. The second historiographical debate concerns the most suitable name for the war
Steganography Algorithm to Hide Secret Message inside an Image (2011)

In this paper, the authors propose a new algorithm to hide data inside image using steganography technique. The proposed algorithm uses binary codes and pixels inside an image. The zipped file is used before it is converted to binary codes to maximize the storage of data inside the image. By applying the proposed algorithm, a system called Steganography Imaging System (SIS) is developed. The system is then tested to see the viability of the proposed algorithm. Various sizes of data are stored inside the images and the PSNR (Peak signal-to-noise ratio) is also captured for each of the images tested. Based on the PSNR value of each images, the stego image has a higher PSNR value. Hence this new steganography algorithm is very efficient to hide the data inside the image.
Ecotoxicity of Ionic Liquids Towards Vibrio fischeri: Experimental and QSAR Studies (2017)

Ionic liquids (ILs) have gained significant attention within the academic and industrial circle owing to their attractive and unique characters. However, the usual green image of the ionic liquids mainly associated with their low vapour pressure has become increasingly doubtful. Several recent studies have highlighted the underestimated ILs toxicity which has not been adequately addressed. Therefore, improving the understanding of the ionic liquids toxicity towards aquatic organisms will undoubtedly lead to formulation of right solutions to address the toxicity problem hence contributing towards the development of green and sustainable ILs‐based technology. The chapter provides a collective review of studies conducted on the effect of ILs structure on toxicity, specifically focussing on the various types of cations and anions, and the length of the alkyl chain attached. Based on the qualitative outcome from the review, a discussion on the development of statistical modelling on the impact of ILs structural features towards the overall toxicity is presented. The application of quantitative structure activity relationship (QSAR) for developing the predictive model for toxicity is highlighted.
An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup (2018)

Primary support from the NIH, grants K23HL123778, K12HL11999, U19AI077439, DK072517, U01HL137880, K24HL137013 and R01HL121774 and contracts HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C, HHSN268200900019C and HHSN268200900020C.
Photoswitchable Spiropyran Dyads for Biological Imaging (2016)

The synthesis of a small-molecule dyad consisting of a far-red-emitting silicon rhodamine dye that is covalently linked to a photochromic spironaphthothiopyran unit, which serves as a photoswitchable quencher, is reported. This system can be switched reversibly between the fluorescent and nonfluorescent states using visible light at wavelengths of 405 and 630 nm, respectively, and it works effectively in aqueous solution. Live-cell imaging demonstrates that this dyad has several desirable features, including excellent membrane permeability, fast and reversible modulation of fluorescence by visible light, and good contrast between the bright and dark states.