gebhart/patrepeval huggingface dataset:
Optical performance of an oscillating, pinned-contact double droplet liquid lens (2011)

Liquid droplets can produce spherical interfaces that are smooth down to the molecular scale due to surface tension. For typical gas/liquid systems, spherical droplets occur on the millimeter and smaller scales. By coupling two droplets, with contact lines pinned at each edge of a cylindrical hole through a plate, a biconvex lens is created. Using a sinusoidal external pressure, this double droplet system (DDS) can be readily forced to oscillate at resonance. The resulting change in the curvatures of the droplets produces a time-varying focal length. Such an oscillating DDS was introduced in 2008 [Nat. Photonics 2, 610 (2008)]. Here we provide a more comprehensive description of the system's optical performance, showing the effects of liquid volume and driving pressure amplitude on the back focal distance, radii of curvature, object distance, and image sharpness.
Stereospecific synthesis of leukotriene antagonists (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific synthesis of leukotriene antagonistsThomas W. Ku, Karen H. Kondrad, and John G. GleasonCite this: J. Org. Chem. 1989, 54, 14, 3487–3491Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/jo00275a045https://doi.org/10.1021/jo00275a045research-articleACS PublicationsRequest reuse permissionsArticle Views185Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Circuit routing over heterogeneous optical networks (2011)

We describe an architecture solution for performing cost-effective circuit routing over multi-vendor heterogeneous DWDM networks, including building blocks, data flow, reachability matrix generation, cost model, diversity, regenerator and wavelength assignments.
Internal Transcribed Spacer Regions 1 and 2 and Random Amplified Polymorphic DNA Analysis of<i>Didymella bryoniae</i>and Related<i>Phoma</i>Species Isolated from Cucurbits (2002)

ABSTRACT Didymella bryoniae (anamorph Phoma cucurbitacearum) is the causal agent of gummy stem blight, although other Phoma species are often isolated from cucurbit plants exhibiting symptoms of the disease. The molecular and phylogenetic relationships between D. bryoniae and these Phoma species are unknown. Isolates of D. bryoniae and Phoma obtained from cucurbits grown at various geographical locations in the United States were subjected to random amplified polymorphic DNA (RAPD) analysis and internal transcribed spacer (ITS) sequence analysis (ITS-1 and ITS-2) to determine the molecular and phylogenetic relationships within and between these fungi. Using RAPD fingerprinting, 59 isolates were placed into four phylogenetic groups, designated RAPD group (RG) I, RG II, RG III, and RG IV. D. bryoniae isolates clustered in either RG I (33 isolates), RG II (12 isolates), or RG IV (one isolate), whereas all 13 Phoma isolates clustered to RG III. There was greater than 99% sequence identity in the ITS-1 and ITS-2 regions between isolates in RG I and RG II, whereas isolates in RG III, P. medicaginis ATCC 64481, and P. exigua ATCC 14728 clustered separately. On muskmelon seedlings, a subset of RG I isolates were highly virulent (mean disease severity was 71%), RG II and RG IV isolates were slightly virulent (mean disease severity was 4%), and RG III isolates were nonpathogenic (disease severity was 0% for all isolates). The ITS sequences indicate that RG I and RG II are both D. bryoniae, but RAPD fingerprints and pathogenicity indicate that they represent two different molecular and virulence subgroups.
Intersubunit Structure within Heterodimers of Medium-Chain Prenyl Diphosphate Synthases. Formation of a Hybrid-Type Heptaprenyl Diphosphate Synthase (1998)

Journal Article Intersubunit Structure within Heterodimers of Medium-Chain Prenyl Diphosphate Synthases. Formation of a Hybrid-Type Heptaprenyl Diphosphate Synthase Get access Ayumi Koike-Takeshita, Ayumi Koike-Takeshita *Bio Research Laboratory, Toyota Motor Corporation/Toyota-cho 1, Toyota, Aichi 471-0826 Search for other works by this author on: Oxford Academic PubMed Google Scholar Tanetoshi Koyama, Tanetoshi Koyama 2 †Institute for Chemical Reaction Science, Tohoku University/Aoba-ku, Sendai, Miyagi 980-8577 2 To whom correspondence should be addressed: Tel: +81-22-217-5621, Fax: +81-22-217-5620, E-mail: koyama@icrs.tohoku.ac.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar Kyozo Ogura Kyozo Ogura †Institute for Chemical Reaction Science, Tohoku University/Aoba-ku, Sendai, Miyagi 980-8577 Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 124, Issue 4, October 1998, Pages 790–797, https://doi.org/10.1093/oxfordjournals.jbchem.a022181 Published: 01 October 1998 Article history Received: 25 May 1998 Published: 01 October 1998
Sand Cleanouts With Coiled Tubing: Choice of Process, Tools and Fluids (2010)

Summary Cleaning fill from wellbores is the most common coiled tubing (CT) application. The process is a function of multiple variables including fluid properties, flow velocities, wellbore geometry and deviation, pipe eccentricity, particle properties, fill penetration rate and wiper trip speed. Removing fill from wells with low bottom hole pressures (BHP) can be challenging especially if wells are completed with smaller diameter production tubulars which significantly reduce circulation flow cross-section and choke flow(1). Such challenges are further compounded by high deviation or horizontal well trajectories especially in large diameter wellbores. A variety of cleanout methods have been developed in the past, often incorporating high circulation rates, special fluids, wiper trips, or reverse circulation to remove solids. Many of these conventional sand cleanout methods often apply excess hydrostatic pressure on the formation, resulting in lost circulation in pressure depleted reservoirs. The conventional solution to overcome excess hydrostatic pressure has been to include nitrogen to reduce fluid density and thus lessen the hydrostatic head; however, sand vacuuming technology using a concentric coiled tubing (CCT) with a downhole jet pump is an alternative technique for removing fill without placing a hydrostatic load on the reservoir. This paper reviews the individual sand cleanout systems and discusses the advantages and limitations related to each method. In recent years, cleaning sand using the wiper trip method has become the preferred technique. However, an appropriate pump rate and reservoir pressure are needed to maintain a proper return flow rate to carry the sands to the surface. For pressure-depleted reservoirs completed with horizontal wells, a sand vacuuming system can be used to efficiently remove the debris without circulating nitrogen and without high pump rates. When the fill cannot be removed from large-diameter deviated wellbores using conventional low-cost cleanout fluids, then fluids with high solids suspension capability (under shear conditions) in conjunction with wiper tripping may be an economical option. The main application for the reverse circulation technique is cleaning sand from large diameter wellbores when the necessary pump rates for conventional "forward" circulation are not achievable. A venturi junk bailer is often used to retrieve larger or heavier material which cannot be circulated out by traditional methods. Field cases are provided, demonstrating how to select the proper cleaning method and how to efficiently remove sand from a wellbore based on both operational and logistical conditions.
GigaView parallel image server performance analysis (1994)

. Professionals in various fields such as medical imaging, biology and civil engineering require rapid access to huge amounts of uncompressed pixmap image data. Multi-media interfaces further increase the need for large image databases. In order to fulfill these requirements, the GigaView parallel image server architecture relies on arrays of intelligent disk nodes, each disk node being composed of one processor and one disk. This contribution analyzes through simulation and experimentation the behavior of the GigaView under single and multiple requests, and compares it to the behavior of RAID servers. It evaluates image visualization window access times under various parameters such as load factors and the number of cooperating disk nodes. Under single request, the GigaView image server can be modeled as a single high-throughput low-latency secondary storage device. Under multiple requests, the notions of utilization and maximum sustainable throughput define accurately the behavior of...
A Novel Mycothiol-Dependent Detoxification Pathway in Mycobacteria Involving Mycothiol <i>S</i>-Conjugate Amidase (2000)

Mycothiol, 1-D-myo-inosityl-2-(N-acetylcysteinyl)amido-2-deoxy-alpha-D-glucopyranoside (MSH), is composed of N-acetylcysteine (AcCys) amide linked to 1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside (GlcN-Ins) and is the major thiol produced by most actinomycetes. When Mycobacterium smegmatis was treated with the alkylating agent monobromobimane (mBBr), the cellular mycothiol was converted to its bimane derivative (MSmB). The latter was rapidly cleaved to produce GlcN-Ins and the bimane derivative of N-acetylcysteine (AcCySmB), a mercapturic acid that was rapidly exported from the cells into the medium. The other product of cleavage, GlcN-Ins, was retained in the cell and utilized in the resynthesis of mycothiol. The mycothiol S-conjugate amidase (amidase) responsible for cleaving MSmB was purified to homogeneity from M. smegmatis. A value of K(m) = 95 +/- 8 microM and a value of k(cat) = 8 s(-)(1) was determined for the amidase with MSmB as substrate. Activity with 100 microM mycothiol or with the monobromobimane derivative of 1-D-myo-inosityl-2-(L-cysteinyl)amido-2-deoxy-alpha-D-glucopyra nos ide (CySmB-GlcN-Ins) or of 2-(N-acetyl-L-cysteinyl)amido-2-deoxy-(alpha, beta)-D-glucopyranoside (AcCySmB-GlcN) was at least 10(3) lower than with 100 microM MSmB, demonstrating that the amidase is highly specific for S-conjugates of mycothiol. Conjugates of mycothiol with the antibiotic cerulenin, N-ethylmaleimide, 3-(N-maleimidopropionyl)-biocytin, and 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin also exhibited significant activity. The sequence of the amino-terminal 20 residues was determined, and an open reading frame (Rv1082) coding for 288 residues having an identical predicted amino-terminal amino acid sequence was identified in the Mycobacterium tuberculosis genome. The Rv1082 gene (mca) from M. tuberculosis was cloned and expressed in Escherichia coli, and the expressed protein was shown to have substrate specificity similar to the amidase from M. smegmatis. These results indicate that mycothiol and mycothiol S-conjugate amidase play an important role in the detoxification of alkylating agents and antibiotics.
Tolerating faults in hypercubes using subcube partitioning (1992)

The authors examine the issue of running algorithms on a hypercube which has both node and edge faults, and they assume a worst-case distribution of the faults. It is proven that for any constant c, an n-dimensional hypercube (n-cube) with n/sup c/ faulty components contains a fault-tree subgraph that can implement a large class of hypercube algorithms with only a constant factor slowdown. In addition, the approach yields practical implementations for small numbers of faults. For example, it is shown that any regular algorithm can be implemented on an n-cube that has at most n-1 faults with slowdowns of at most two for computation and at most four for communication. This is the first result showing that an n-cube can tolerate more than O(n) arbitrarily placed faults with a constant factor slowdown.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Shaping process makes fuels (1985)

The Mobil Olefin to Gasoline and Distillate (MOGD) process is described in which light olefinic compunds can be converted to high quality gasoline and distillate. This process, now ready for commercialization is based on a unique synthetic zeolite catalyst, the shape of which selectively oligomerizes light olefins to higher molecular weight iso-olefins. The highly flexible process can be designed to produce distillate/gasoline ratios of 0/100 to 90/10 for a commercial plant, depending on market requirements. MOGD is applicable to a wide range of feed streams ranging from ethylene to 400 degrees F end point olefinic naphtha. The process has been tested using commercially produced catalyst in refinery-scale equipment.
A Phase 1/2 Trial of a Tetravalent Live-Attenuated Dengue Vaccine in Flavivirus-Native Thai Infants (2006)

Abstract : The Walter Reed Army Institute of Research (WRAIR) has produced a tetravalent live-attenuated dengue vaccine that has been well tolerated and immunogenic in U.S. adults and Thai children. As infants are considered by many as an important age group for vaccination in dengue-endemic countries, we evaluated the vaccine in Thai flavivirus-na ve infants who are at risk for dengue.
Synthesis and evaluation of the functional oligonucleotides-PEG conjugates (2004)

We have previously demonstrated that the phenylsulfide and phenylsulfoxide derivatives of 2-amino-6-vinylpurine exhibit efficient cross-linking with high selectivity towards cytidine through synchronous activation within duplex. In this study, we synthesized their conjugates with PEG for possible application to in vitro as well as in vivo antisense agents. Thus, the ODN (2) with the antisense sequence toward luciferase was synthesized, having the 2-amino-6-vinylpurine nucleoside analog at the reactive site for targeting C and the amino linker at the 3' terminal. The vinyl group was transformed to the corresponding substituted phenylsulfide derivatives (3), and then the amino group of the 3' end was converted to the thiopropionyl group (4). The thiol nucleophile of 4 was reacted to the acid-responsive PEG2 in good isolated yields (55-62%).
Second Generation Grp94‐Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer (2017)

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum (ER) resident isoform of the 90 kDa heat shock protein (Hsp90) family and its inhibition represents a promising therapeutic target for the treatment of many diseases. Modification of the first generation cis-amide bioisostere imidazole to alter the angle between the resorcinol ring and the benzyl side chain via cis-amide replacements produced compounds with improved Grp94 affinity and selectivity. Structure-activity relationship studies led to the discovery of compound 30, which exhibits 540 nm affinity and 73-fold selectivity towards Grp94. Grp94 is responsible for the maturation and trafficking of proteins associated with cell signaling and motility, including select integrins. The Grp94-selective inhibitor 30 was shown to exhibit potent anti-migratory effects against multiple aggressive and metastatic cancers.
Variable Interference Azimuth Angle in Double-Biprism Electron Interferometry (2005)

Double-biprism electron interferometry has been extended by enabling the control of azimuth rotation between the two filament electrodes of the biprisms. Varying the azimuth angle between the filaments induces two parameters not found in conventional electron interferometry: the azimuth angle of the interference fringes and the vertical length of the interference region. This extended interferometry enables us to obtain the phase profile of one-dimensionally structured materials widely along their elongated direction without reconstruction. Evaluation of the overall performance of the interferometry theoretically and experimentally demonstrated that it provides additional flexibility for interferometry.
<i>In Vitro</i> Evaluation of Hybrid Cooperative Complexes of Hyaluronic Acid as a Potential New Ophthalmic Treatment (2018)

The results suggest that the developed formulation may be a promising topical ophthalmic medical treatment.
Complexes of Bacterial Nicotinate Mononucleotide Adenylyltransferase with Inhibitors: Implication for Structure-Based Drug Design and Improvement (2010)

Bacterial nicotinate mononucleotide adenylyltransferase encoded by the essential gene nadD plays a central role in the synthesis of the redox cofactor NAD(+). The NadD enzyme is conserved in the majority of bacterial species and has been recognized as a novel target for developing new and potentially broad-spectrum antibacterial therapeutics. Here we report the crystal structures of Bacillus anthracis NadD in complex with three NadD inhibitors, including two analogues synthesized in the present study. These structures revealed a common binding site shared by different classes of NadD inhibitors and explored the chemical environment surrounding this site. The structural data obtained here also showed that the subtle changes in ligand structure can lead to significant changes in the binding mode, information that will be useful for future structure-based optimization and design of high affinity inhibitors.
LONG-PERIOD FIBER GRATING–BASED NUCLEAR RADIATION SENSORS FOR HIGH-LEVEL DOSE APPLICATIONS (2012)

We present for first time the detailed investigation on the effect of MGy (106 Gy) dose level of gamma radiation on the parameters of CO2 laser-written long-period fiber gratings (LPFGs) in B/Ge-doped single-mode fibers with particular attention to lower-order modes and higher order nonturnaround point (non-TAP) modes. Wavelength shifts up to 11 nm for 100 kGy dose and a further shift of 20 nm (1.5 nm/100 kGy) for dose of 900 kGy (total 1 MGy) were observed. Further, the radiation-induced shifts of resonant modes did not saturate up to a 1 MGy dose. No remarkable changes were observed in width and amplitude of the resonant dips during in-situ measurements up to the full dose irradiation. The radiation sensitivity up to 100 kGy was found to be independent of the grating period. This study shows that LPFGs in boron-doped fibers are strong candidates for very high-dose sensing applications such as in super Large Hadron Collider (LHC) and International Thermonuclear Experimental Reactor (ITER).
Synthesis of Al/SiC based functionally gradient materials using technique of gradient slurry disintegration and deposition: Effect of stirring speed (2002)

In the present study, Al/SiC based functionally gradient materials (FGMs) were successfully synthesised using the gradient slurry disintegration and deposition technique. Gradients of SiC for the starting weight of 18% were successfully established by varying the stirring speed of the molten melt. The results revealed, in general, increases in the weight percentage and clustering tendency of SiC, porosity, and microhardness and a reduction in grain size, with increasing distance from the base of the FGM ingots. The results also showed that an increase in the stirring speed increases the homogeneity of SiC particulates distribution, thus resulting in a decrease in the gradient of reinforcement along the deposition direction. Furthermore, an increase in the stirring speed decreases the number of clusters formed per unit area. An attempt has been made in the present work to establish the trend between processing parameters, such as stirring speed and the gradient of SiC particulates realised in the ingots.
Comparison of Single- and Double-Bundle Anterior Cruciate Ligament Reconstructions in Restoration of Knee Kinematics and Anterior Cruciate Ligament Forces (2010)

Both single-bundle and double-bundle techniques cannot restore the rotational laxities and the ACL force distributions of the intact knee.
Therapy with Coenzyme Q10 for Patients with Periodontal Disease. 1. Effect of Coenzyme Q10 on Subgingival Microorganisms. (1993)

[in Japanese]
Association Between Genetic Polymorphisms in the Prostate-Specific Antigen Gene Promoter and Serum Prostate-Specific Antigen Levels (2003)

Genetic variations in the PSA promoter are associated with serum PSA levels in men without prostatic disease. PSA promoter genotype information may help to refine models of PSA cutoff values.
Rapid one-shot acquisition of dynamic VR avatars (2017)

We present a system for rapid acquisition of bespoke, animatable, full-body avatars including face texture and shape. A blendshape rig with a skeleton is used as a template for customization. Identity blendshapes are used to customize the body and face shape at the fitting stage, while animation blendshapes allow the face to be animated. The subject assumes a T-pose and a single snapshot is captured using a stereo RGB plus depth sensor rig. Our system automatically aligns a photo texture and fits the 3D shape of the face. The body shape is stylized according to body dimensions estimated from segmented depth. The face identity blendweights are optimised according to image-based facial landmarks, while a custom texture map for the face is generated by warping the input images to a reference texture according to the facial landmarks. The total capture and processing time is under 10 seconds and the output is a light-weight, game-engine-ready avatar which is recognizable as the subject. We demonstrate our system in a VR environment in which each user sees the other users' animated avatars through a VR headset with real-time audio-based facial animation and live body motion tracking, affording an enhanced level of presence and social engagement compared to generic avatars.
A Dual-Stage Attention-Based Recurrent Neural Network for Time Series Prediction (2017)

The Nonlinear autoregressive exogenous (NARX) model, which predicts the current value of a time series based upon its previous values as well as the current and past values of multiple driving (exogenous) series, has been studied for decades. Despite the fact that various NARX models have been developed, few of them can capture the long-term temporal dependencies appropriately and select the relevant driving series to make predictions. In this paper, we propose a dual-stage attention-based recurrent neural network (DA-RNN) to address these two issues. In the first stage, we introduce an input attention mechanism to adaptively extract relevant driving series (a.k.a., input features) at each time step by referring to the previous encoder hidden state. In the second stage, we use a temporal attention mechanism to select relevant encoder hidden states across all time steps. With this dual-stage attention scheme, our model can not only make predictions effectively, but can also be easily interpreted. Thorough empirical studies based upon the SML 2010 dataset and the NASDAQ 100 Stock dataset demonstrate that the DA-RNN can outperform state-of-the-art methods for time series prediction.