gebhart/patrepeval huggingface dataset:
Control of MMST RTP: repeatability, uniformity, and integration for flexible manufacturing [ICs] (1994)

A real-time multivariable strategy is used to control the uniformity and repeatability of wafer temperature in rapid thermal processing (RTP) semiconductor device manufacturing equipment. This strategy is based on a physical model of the process where the model parameters are estimated using an experimental design procedure. The internal model control (IMC) law design methodology is used to automatically compute the lamp powers to a multizone array of concentric heating zones to achieve wafer temperature uniformity. Control actions are made in response to real-time feedback information provided by temperature sensing, via pyrometry, at multiple points across the wafer. Several modules, including model-scheduling and antiovershoot, are coordinated with IMC to achieve temperature control specifications. The control strategy, originally developed for prototype equipment at Stanford University, is analyzed via the customization, integration, and performance on eight RTP reactors at Texas Instruments conducting thirteen different thermal fabrication operations of two sub-half-micron CMOS process technologies used in the the Microelectronics Manufacturing Science and Technology (MMST) program.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide (2015)

A biotinylated heparosan hexasaccharide was synthesized using a one-pot multi-enzyme strategy, in situ activation and transfer of N-trifluoroacetylglucosamine (GlcNTFA) to a heparin backbone significantly improved the synthetic efficiency. The biotinylated hexasaccharide could serve as a flexible core to diversify its conversion into heparan sulfate isoforms with potential biological applications and therapeutics.
A Flexible Workload Generator for Simulating Stream Computing Systems (2011)

Stream computing is an emerging computational model for performing complex operations on and across multi-source, high volume data flows. Given that the deployment of the model has only started, the pool of mature applications employing this model is fairly small, and therefore the availability of workloads for various types of applications is scarce. Thus, there is a need for synthetic generation of large-scale workloads for evaluation of stream computing applications at scale. This paper presents a framework for producing synthetic workloads for stream computing systems. Our framework extends known random graph generation concepts with stream computing specific features, providing researchers with realistic input stream graphs and allowing them to focus on system development, optimization and analysis. Serving the goal of covering a disparity of potential applications, the presented framework exhibits high user-controlled configurability. The produced workloads could be used to drive simulations for performance evaluation and for proof-of-concept prototyping of processing, networking and operating system hardware and software.
FlowME: Lattice-based Traffic Measurement (2012)

Flow-based traffic measurement is a very challenging problem: Managing counters for each individual traffic flow in hardware resources knowingly struggle to scale with high-speed links. In this paper we propose a novel lattice theory-based approach that improves flow-based measurement performances and scales by keeping the number of the maintained hardware counters to a minimum (result mathematically established in the paper). The crucial contribution of the lattice is to map the computational semantics of the packet processing to user requests for traffic measurement thus allowing for a better-informed and focused counter assignment. An implementation over an Openflow switch, FlowME, was developed and evaluated upon its memory usage, performance overhead, and processing effort to generate the minimal solution. Experimental results indicate a significant decrease in resource consumption.
Medicinal Chemistry, Pharmacology, and Biological Actions of Peptide Ligands Selective for the Nociceptin/Orphanin FQ Receptor (2013)

Nociceptin/orphanin FQ (N/OFQ; FGGFTGARKSARKLANQ) was identified via reverse pharmacology strategies as the endogenous ligand of a previously orphan GPCR now referred to as N/OFQ peptide (NOP) receptor. The N/OFQ – NOP receptor system is widely distributed in the nervous system where it modulates several different biological functions. Structure relationship studies performed on the N/OFQ sequence allowed to generate NOP selective ligands encompassing full and partial agonist as well as pure antagonist activity, to increase their potency, metabolic stability, and in vivo duration of action. These peptide NOP ligands were used to investigate the consequences of NOP receptor activation and block thus suggesting the possible therapeutic indications of drugs interacting with this receptor. Evidence coming from these studies, together with findings obtained with knockout animals and non peptide NOP ligands, suggests that the most promising indications for NOP antagonists are depression and Parkinson disease and for agonists anxiety, drug abuse, cough, and pain (after spinal administration). In addition, clinical studies demonstrated that intravesical instillation of N/OFQ elicits beneficial effects in patients with overactive bladder.
The Scripps Research Institute (La Jolla, CA) (2023)

The invention provides proteins attached to solid supports, and methods of preparing such solid support-bound proteins are provided. The proteins are attached to solid supports by means of an unnatural amino acid incorporated into the protein, which unnatural amino acid includes a reactive group that can react with a second reactive group that is attached to a solid support.
Effect of organic passivation on photoinduced electron transfer across the quantum dot/TiO2 interface (2011)

We report a study of the internal quantum efficiency (IQE) of CdSe quantum-dot (QD)-sensitized solar cells prepared by direct adsorption of pre-synthesized QDs, passivated with either tri-n-octylphosphine oxide (TOPO) or n-butylamine (BA), onto a nanocrystalline TiO(2) film.
Hafnia alvei HA4597 Strain Reduces Food Intake and Body Weight Gain and Improves Body Composition, Glucose, and Lipid Metabolism in a Mouse Model of Hyperphagic Obesity (2019)

Use of new generation probiotics may become an integral part of the prevention and treatment strategies of obesity. The aim of the present study was to test the efficacy of a potential probiotic strain of lactic bacteria Hafnia alvei (H. alvei) HA4597™, in a mouse model of obesity characterized by both hyperphagia and diet-induced adiposity. For this purpose, 10-week-old high-fat-diet (HFD)-fed hyperphagic ob/ob male mice received a daily treatment with 1.4 × 1010 CFU of H. alvei for 38 days. Effects of H. alvei were compared to those of a lipase inhibitor orlistat (80 mg/kg daily) and a vehicle (NaCl 0.9%) in HFD-fed ob/ob mice. A control untreated group of ob/ob mice received the standard diet throughout the experiment. The vehicle-treated HFD group displayed increased food intake, worsening of adiposity, and glycemia. Treatment with H. alvei was accompanied by decreased body weight and fat-mass gain along with reduced food intake to the level of the standard-diet-fed mice. At the end of the experiment, the group treated with H. alvei showed a decrease of glycemia, plasma total cholesterol, and alanine aminotransferase. The orlistat-treated mice showed a lower rate of body weight gain but were hyperphagic and hyperglycemic. These results demonstrate the beneficial anti-obesity and metabolic effects of H. alvei HA4597™ in mice with obesity resulting from hyperphagia and diet-induced adiposity.
Effect of Solvent on the Physical and Morphological Properties of Poly(Lactic Acid) Nanofibers Obtained by Solution Blow Spinning (2014)

Solution blow spinning (SBS) is a simple, safe, and inexpensive alternative to electrospinning for making nanofibers from polymer solutions. However, since SBS is a relatively new technique, there is a general lack of information on polymer solutions and properties that affect fiber morphology and intrinsic properties. The present study reports the solution properties of poly (lactic acid) (PLA) dissolved in chloroform, dichloromethane, and dichloroethane at 4%, 6%, or 8% (w/v) and the properties of fibers made by SBS. In contrast to 4% polymer solutions, fibers made from 6% polymer solutions had few beads and diameters in the range of 120–320 nm. Diameters were greater (311–570 nm) for fibers made from 8% polymer solutions. Solvent evaporation rate affected the fiber porosity and formation. Hansen solubility parameters indicate that dichloromethane was the solvent most miscible with PLA. Fibers made with PLA in dicloromethane had the broader range in fiber diameter. Hansen parameters could be a valuable predictive tool for identifying highly miscible polymer/solvent systems for the SBS process. Polymer solutions with high viscoelasticity and viscosity were well suited for the SBS process. Fibers made from polymer solutions containing dichloromethane had lower crystallinity compared to fibers made from the other solvents.
Regioselective C-2 and C-6 Substitution of (<i>S</i>)-Nicotine and Nicotine Derivatives (2005)

[reaction: see text] Regioselective deprotonations of (S)-nicotine and derivatives at the C-2 and C-6 positions of the pyridine ring were performed in good to excellent yields. These methodologies allow the direct introduction of a plethora of functional groups onto the pyridine ring of nicotine.
The human breast cell DNA synthesome: its purification from tumor tissue and cell culture. (1996)

In this report, we describe for the first time the isolation and purification of a multiprotein complex for DNA replication from MDA MB-468 human breast cancer cells. This complex, which we designate the DNA synthesome, fully supports the in vitro replication of simian virus 40 (SV40) origin-containing DNA in the presence of the viral large T-antigen. Since the SV40 virus utilizes the host's cellular proteins for its own DNA replication, our results indicate that the DNA synthesome may play a role not only in viral DNA synthesis but in human breast cell DNA replication as well. Our studies demonstrate that the following DNA replication proteins constitute the DNA synthesome: DNA polymerase alpha, DNA primase, DNA polymerase delta, proliferating cell nuclear antigen, replication protein A, replication factor C, DNA topoisomerases I, II, and DNA polymerase epsilon. In addition, we successfully isolated the DNA synthesome from human breast tumor tissue as well as from xenografts from nude mice injected with the human breast cancer cell line MCF-7. The DNA synthesome purified from the breast cancer tissues fully supports SV40 DNA replication in vitro. Furthermore, our results obtained from a novel forward mutagenesis assay suggest that the DNA synthesome isolated from a nonmalignant breast cell line mediates SV40 DNA replication by an error-resistant mechanism. In contrast, the DNA synthesome derived from malignant breast cells and tissue exhibited a lower fidelity for DNA synthesis in vitro. Overall, our data support the role of the DNA synthesome as mediating breast cell DNA replication in vitro and in vivo.
Two Abscisic Acid-Responsive Plastid Lipase Genes Involved in Jasmonic Acid Biosynthesis in <i>Arabidopsis thaliana</i> (2018)

Chloroplast membranes with their unique lipid composition are crucial for photosynthesis. Maintenance of the chloroplast membranes requires finely tuned lipid anabolic and catabolic reactions. Despite the presence of a large number of predicted lipid-degrading enzymes in the chloroplasts, their biological functions remain largely unknown. Recently, we described PLASTID LIPASE1 (PLIP1), a plastid phospholipase A<sub>1</sub> that contributes to seed oil biosynthesis. The <i>Arabidopsis thaliana</i> genome encodes two putative PLIP1 paralogs, which we designated PLIP2 and PLIP3. PLIP2 and PLIP3 are also present in the chloroplasts, but likely with different subplastid locations. In vitro analysis indicated that both are glycerolipid A<sub>1</sub> lipases. In vivo, PLIP2 prefers monogalactosyldiacylglycerol as substrate and PLIP3 phosphatidylglycerol. Overexpression of <i>PLIP2</i> or <i>PLIP3</i> severely reduced plant growth and led to accumulation of the bioactive form of jasmonate and related oxylipins. Genetically blocking jasmonate perception restored the growth of the <i>PLIP2/3</i>-overexpressing plants. The expression of <i>PLIP2</i> and <i>PLIP3</i>, but not <i>PLIP1</i>, was induced by abscisic acid (ABA), and <i>plip1 plip2 plip3</i> triple mutants exhibited compromised oxylipin biosynthesis in response to ABA. The <i>plip</i> triple mutants also showed hypersensitivity to ABA. We propose that PLIP2 and PLIP3 provide a mechanistic link between ABA-mediated abiotic stress responses and oxylipin signaling.
Microfluidic Integration of Aperiodic Gold Nanoparticle Arrays for Local Refractive Index Sensing (2011)

We present microfluidic integration of a novel optical sensing technique based on distinctive structural color modifications in aperiodic nano-structures. The liquid-induced index sensitivity of the proposed devices is quantified by autocorrelation analysis in the visible spectral range.
Complement Inhibitors Targeted to the Proximal Tubule Prevent Injury in Experimental Nephrotic Syndrome and Demonstrate a Key Role for C5b-9 (2005)

In glomerular diseases of diverse etiologies, dysfunction of the glomerular barrier to protein passage results in proteinuria, and proteinuria is considered an independent risk factor that plays a direct role in inflammation, interstitial fibrosis, and renal failure. The mechanism by which proteinuria leads to nephrotoxic injury is unclear, but a role for complement in mediating interstitial damage appears likely. We describe a strategy for Ag-specific targeting of complement inhibitors using a single chain Ab fragment and show that complement inhibitors targeted to the tubular epithelium protect against tubulointerstitial injury and renal dysfunction in a rat model of puromycin-induced nephrosis. The targeting of systemically administered complement inhibitors markedly enhanced their efficacy and obviated the need to systemically inhibit complement, thus reducing the risk of compromising host defense and immune homeostasis. Targeted inhibition of complement activation by Crry, and of membrane attack complex (MAC) formation by CD59 was equally therapeutic, demonstrating that the MAC plays a key role in proteinuria-induced tubulointerstitial injury. CD59 activity was dependent on its being targeted to the site of complement activation, and this is the first report of specific inhibition of the MAC in vivo after systemic administration of inhibitor. The data establish the MAC is a valid target for pharmaceutical intervention in proteinuric disorders and provide an approach to investigate the role of the MAC in complement-dependent disease under clinically relevant conditions.
EUV Plasma Source with IR Power Recycling (2016)

Laser power requirements for an EUV laser-produced plasma source can be reduced by using power-recycling optics to reflect plasma-scattered IR radiation back onto the plasma. Previously proposed spherical retroreflective mirrors can be used to form an inverted image of the plasma on itself, but an erect (non-inverted) image would be more tolerant of positional alignment errors. Erect-imaging optical design alternatives for power recycling are described in this paper.
High-Speed Melting Analysis: The Effect of Melting Rate on Small Amplicon Microfluidic Genotyping (2017)

Microfluidics enables genotyping by melting analysis at rates up to 32 °C/s, requiring <1 s to acquire an entire melting curve. High-speed melting reduces the time for melting analysis, decreases errors, and improves genotype discrimination of small amplicons. Combined with extreme PCR, high-speed melting promises nucleic acid amplification and genotyping in < 1 min.
Gelled Oil: New Chemistry Using Surfactants (2005)

Abstract Water-based fluids can damage some sandstone formations due to various reasons including clay swelling, emulsions, water-block, and wettability alternations. Oil-based fluids are less damaging than water-based systems to the hydrocarbon bearing formations. Conventional gelled oils (GO) have numerous limitations; however, they are used in formations that are highly sensitive to water. Aluminum carboxylate technology has been used for several decades, aluminum phosphate ester, however, has remained the preferred gelled oil system for the last thirty years. This paper describes the development of novel surfactant-based gelled oil (S-GO). This new technology uses surfactants to develop the viscosity of diesel. Unlike conventional gelled oil systems, this gelled oil is not sensitive to the nature of base oil or additive concentrations. The S-GO system, with an order of magnitude higher low shear viscosity, has much better solids suspension characteristics. This cleaner fluid also exhibits low friction characteristics, allowing pumping at higher rates. These unique features make the new S-GO system highly attractive for fracturing, frac-packing, sand control, coiled tubing cleanouts, and as kill pills. This fluid system can be used for applications up to 300°F.
Homodyne reconstruction and IDEAL water–fat decomposition (2005)

Multipoint water-fat separation methods have received renewed interest because they provide uniform separation of water and fat despite the presence of B0 and B1 field inhomogeneities. Unfortunately, full-resolution reconstruction of partial k-space acquisitions has been incompatible with these methods. Conventional homodyne reconstruction and related algorithms are commonly used to reconstruct partial k-space data sets by exploiting the Hermitian symmetry of k-space in order to maximize the spatial resolution of the image. In doing so, however, all phase information of the image is lost. The phase information of complex source images used in a water-fat separation acquisition is necessary to decompose water from fat. In this work, homodyne imaging is combined with the IDEAL (iterative decomposition of water and fat with echo asymmetry and least squares estimation) method to reconstruct full resolution water and fat images free of blurring. This method is extended to multicoil steady-state free precession and fast spin-echo applications and examples are shown.
Measuring the value of human capital investments: the SAP case (2006)

Purpose Over the past three years Accenture developed and applied a new measurement tool that assesses the maturity of an organization's human capital development processes, benchmarks the processes' performance against other organizations, and determines the relationship of each process to bottom line business results. It is designed to help executives make significantly more informed choices about their investments in human capital. This article aims to look at this tool. Design/methodology/approach The tool, known as the human capital development framework, now has been tested in more than 60 organizations. This case describes how one organization used it to help turn around a struggling division. Findings Results of the initial implementations of the framework suggest that financial performance improves as a company improves its scoring in those critical human capital processes with strong relationships to financial success. As an organization moves from one benchmarking quartile to the next in these processes within the framework scoring, its capital efficiency – or the ratio of total annual sales to the capital invested in the operations of the business by shareholders and creditors – improves from 10 to 15 percent. Practical implications The framework outlined in this article provides a tool that enables company leaders to make clear‐eyed assessments of the payoff from human capital investments. It helps organizations diagnose their strengths and weaknesses in key human capital practices, to set investment priorities and track performance, and to establish an empirical link between human capital investments, business practices, and overall business performance. Originality/value Those organizations in the study with more mature human capital processes have better financial performance than those organizations with less mature processes. Specifically, those organizations that focus on processes devoted to three key areas – creating a people strategy aligned with the business strategy, providing supportive work environments, and developing employees by giving them ample opportunities to learn and grow – achieve far greater economic success than those that do not.
A Convenient Approach to Mo<sub>6</sub>S<sub>8</sub>Chevrel Phase Cathode for Rechargeable Magnesium Battery (2014)

A two-step solution chemistry route was used to synthesize ternary Chevrel phase (Cu2Mo6S8) with 5 h annealing at 1000°C under reducing atmosphere. The approach marks a synthesis route different from hitherto described conventional solid-state methods. X-ray diffraction and scanning electron micrograph shows the formation of ∼1–1.5 μm size cuboidal shape Cu2Mo6S8 crystals with unit cell dimensions a ∼ 0.96245 nm and c ∼ 1.01987 nm of molar volume ∼818.14 × 10−3 nm3. De-cuprated Mo6S8 exhibits a discharge capacity ∼76 mAhg−1 with good capacity retention up to ∼50 cycles when cycled at the current rate of 20 mA/g (∼C/6). The excellent rate capability and high Coulombic efficiency (∼99.3% at ∼1.5C rate) of the Mo6S8 cathode renders the solution chemistry route an alternative approach for the synthesis of cuprated Chevrel phase: a known cathode system for magnesium battery.
Proteome analysis in thyroid pathology (2015)

The incidence of thyroid cancer has continuously increased due to its detection in the preclinical stage. Clinical research in thyroid pathology is focusing on the development of new diagnostic tools to improve the stratification of nodules that have biological, practical and economic consequences on the management of patients. Several clinical questions related to thyroid carcinoma remain open and the use of proteomic research in the hunt for new targets with potential diagnostic applications has an important role in the solutions. Many different proteomic approaches are used to investigate thyroid lesions, including mass spectrometry profiling and imaging technologies. These approaches have been applied to different human tissues (cytological specimens, frozen sections, formalin-fixed paraffin embedded tissue or Tissue Micro Arrays). Moreover, other specimens are used for biomarker discovery, such as cell lines and the secretome. Alternative approaches, such as metabolomics and lipidomics, are also used and integrated within proteomics.
Discovery of 6-(Fluoro-<sup>18</sup><i>F</i>)-3-(1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridin-1-yl)isoquinolin-5-amine ([<sup>18</sup>F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs) (2016)

Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases including Alzheimer's disease. In vivo detection of NFTs using PET imaging represents a unique opportunity to develop a pharmacodynamic tool to accelerate the discovery of new disease modifying therapeutics targeting tau pathology. Herein, we present the discovery of 6-(fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine, 6 ([(18)F]-MK-6240), as a novel PET tracer for detecting NFTs. 6 exhibits high specificity and selectivity for binding to NFTs, with suitable physicochemical properties and in vivo pharmacokinetics.