gebhart/patrepeval huggingface dataset:
Rift Valley Fever Virus Structural and Nonstructural Proteins: Recombinant Protein Expression and Immunoreactivity Against Antisera from Sheep (2013)

The Rift Valley fever virus (RVFV) encodes the structural proteins nucleoprotein (N), aminoterminal glycoprotein (Gn), carboxyterminal glycoprotein (Gc), and L protein, 78-kD, and the nonstructural proteins NSm and NSs. Using the baculovirus system, we expressed the full-length coding sequence of N, NSs, NSm, Gc, and the ectodomain of the coding sequence of the Gn glycoprotein derived from the virulent strain of RVFV ZH548. Western blot analysis using anti-His antibodies and monoclonal antibodies against Gn and N confirmed expression of the recombinant proteins, and in vitro biochemical analysis showed that the two glycoproteins, Gn and Gc, were expressed in glycosylated form. Immunoreactivity profiles of the recombinant proteins in western blot and in indirect enzyme-linked immunosorbent assay against a panel of antisera obtained from vaccinated or wild type (RVFV)-challenged sheep confirmed the results obtained with anti-His antibodies and demonstrated the suitability of the baculo-expressed antigens for diagnostic assays. In addition, these recombinant proteins could be valuable for the development of diagnostic methods that differentiate infected from vaccinated animals (DIVA).
Thickness Measurements of Silicon Films Using Partial Coherence Interferometry. (1991)

Abstract : An optical system composed of a Michelson interferometer, a short coherence length edge-emitting diode (ELED), and a fiber-optic-coupler probe has been described and used to measure the thickness of thin silicon charge-coupled device (CCD) films. The measurement precision for samples with a thickness of the order of 10 micrometers is better than 0.1 micrometers and the range of thickness that can be measured can be from a few micrometers to hundreds of micrometers if a suitable source is used. The fiber probe assembly is adaptable for remote in situ measurements of samples within an etching chamber, and the measurement results can be used to control the sample etching process. The fiber probe also allows for localized measurements at selected positions across the area of the sample, and these results can be used for control of thickness uniformity.
A new approach to space diversity combining in microwave digital radio (1985)

In this paper we describe a new approach to dual-channel space diversity combining in microwave digital radio. This approach features (1) adaptive control of the relative amplitudes and phases of the two branch gains; and (2) a search strategy, based on noncoherent spectrum measurements at the combiner output, that simultaneously accounts for both dispersion and noise. Computer programs have been developed to simulate the search process and to analyze the resulting performance. Eight representative channel response pairs are postulated and performance results are presented for each. They show that the scheme provides a high degree of channel equalization over bandwidths up to at least 40 MHz, and that, in receivers not using adaptive equalizers, it offers major improvements in detection performance over selection diversity.
Abstract 3478: Differential level of L-homocysteic acid and lysophosphatidylcholine (16:0) in sera of patients with ovarian cancer (2014)

Abstract Ovarian cancer (OVC) is one of the most difficult cancers to detection in the early periods of its development. Therefore there have been numerous attempts to find a biomarker for OVC, but an accurate diagnostic marker is yet to be discovered. In this study, we profiled OVC candidate metabolites from serum to find potential diagnostic marker for OVC. Information of low-mass-ions (LMIs) in serum was obtained by using MALDI-TOF. MALDI-MS analysis of each serum sample was repeated six times in order to reduce experimental errors. Intensity of LMI mass peak was normalized using total peak area sums. Normalized intensity of LMI was used in principal component analysis-discriminant analysis (PCA-DA) to discriminate 142 OVC from 100 controls. LC-MS/MS was used to identify the selected LMIs. Extracted ion chromatogram (EIC) analysis was used to measure the relative quantity of candidate metabolite from the LMI mass peak areas. The concentration of common metabolite in serum was determined by ELISA. Top 20 LMI mass peaks with weigh factor over 0.05 were selected to separate OVC from controls. Among them two LMIs with 184.05 m/z and 496.30 m/z were identified as L-homocysteic acid (HCA) and lysophosphatidylcholine (LPC) (16:0), respectively. Relative quantity of LPC (16:0) was decreased in OVC serum (P=0.05), whereas the amount of HCA was significantly higher in OVC serum (P&lt;0.001). HCA was not detected in 59 cases out of 63 controls, but most cases of OVC (16 out of 25) showed significantly higher amount of HCA. When the cutoff was 10 nmol/ml, sensitivity and specificity of HCA were 64.0% and 96.9%, respectively. Level of LPC (16:0) was significantly correlated with tumor grade (P=0.045). Both HCA and LPC (16:0) showed correlation with stage and tumor histology, but limited sample number could not assign the statistical significance. HCA alone showed a potential power of biomarker for OVC. Even the stratified screening including LPC (16:0) did not significantly increase the power for OVC screening, our present study showed that a good example of profiling of LMIs in serum can be useful to select and identify candidate metabolites for OVC screening. Citation Format: Yun Hwan Kim, Woong Ju, Seung Cheol Kim, Byong Chul Yoo. Differential level of L-homocysteic acid and lysophosphatidylcholine (16:0) in sera of patients with ovarian cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3478. doi:10.1158/1538-7445.AM2014-3478
Gonadal Peptide Hormones Modulating FSH Secretion (1987)

A variety of hypophysiotropic peptides have been reported to be present in mammalian gonads. Inhibin, a hormone that under most circumstances selectively suppresses the secretion of follicle-stimulating hormone (FSH) but not luteinizing hormone (LH), has been isolated from the gonadal fluids of several species by four groups and characterized as heterodimeric protein consisting of α- and β-polypeptides associated by disulphide bonds. The amino-acid sequences of the precursors of inhibin a-subunits and two distinct inhibin β-subunits (βA and βB) have been deduced from complementary DNA sequences leading to the determination of the primary structures of porcine, bovine and human inhibins. Antibodies to a synthetic peptide encompassing the amino terminal 25 residues of the α-subunit of porcine inhibin were used to develop a specific radioimmunoassay for inhibin that detects inhibins from many species including rat and human. FSH stimulates inhibin production in vivo as well as in vitro from cultured granulosa or Sertoli cells. Passive immunization of rats with anti-inhibin serum during various phases of the estrus cycle causes an elevation in plasma FSH levels. These results support the existence of a feedback relationship between die production of FSH and inhibin. Düring our purification of inhibin from porcine follicular fluid, we noted fractions that could stimulate the secretion of FSH by cultured anterior pituitary cells. One of these FSH Releasing Proteins (FRP) is a homodimer consisting of two inhibin βA-chains linked by disulphide bonds. FRP ist highly potent in stimulating the secretion and biosynthesis of FSH but not of LH or any other pituitary hormone. In contrast to the effects of GnRH and other reported gonadal gonadotropin releasing fractions, the action of FRP is not mediated by GnRH receptors. Opposing local actions of both the αβ-heterodimer (inhibin) and ββ-homodimer (FRP) have been observed in the gonad.
Pulse generator for ion implantation (2002)

Plasma source ion implantation (PSII) requires a high-power pulse generator (megawatts average power and peak pulse power of over 5 MVA) that is efficient, very reliable and robust. The robustness is required because plasma arcs, spits and sputters. Because operator equipment and vacuum failures occur, the modulator must be very tolerant to every possible insult. Megapulse, Inc. has developed a solid-state, high-power modulator that meets all these requirements. By combining soft switching with magnetic pulse compression, an extremely reliable, robust and efficient modulator is obtained. This technique is used in high-power Loran-C transmitters. These transmitters have been installed throughout the world.
Flame retardant diaphragm for acoustic transducers (1986)

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A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target (2018)

Despite the development of newer anti-seizure medications over the past 50 years, 30-40% of patients with epilepsy remain refractory to treatment. One explanation for this lack of progress is that the current screening process is largely biased towards transmembrane channels and receptors, and ignores intracellular proteins and enzymes that might serve as efficacious molecular targets. Here, we report the development of a novel drug screening platform that harnesses the power of zebrafish genetics and combines it with in vivo bioenergetics screening assays to uncover therapeutic agents that improve mitochondrial health in diseased animals. By screening commercially available chemical libraries of approved drugs, for which the molecular targets and pathways are well characterized, we were able to reverse-identify the proteins targeted by efficacious compounds and confirm the physiological roles that they play by utilizing other pharmacological ligands. Indeed, using an 870-compound screen in kcna1-morpholino epileptic zebrafish larvae, we uncovered vorinostat (Zolinza™; suberanilohydroxamic acid, SAHA) as a potent anti-seizure agent. We further demonstrated that vorinostat decreased average daily seizures by ∼60% in epileptic Kcna1-null mice using video-EEG recordings. Given that vorinostat is a broad histone deacetylase (HDAC) inhibitor, we then delineated a specific subset of HDACs, namely HDACs 1 and 3, as potential drug targets for future screening. In summary, we have developed a novel phenotypic, metabolism-based experimental therapeutics platform that can be used to identify new molecular targets for future drug discovery in epilepsy.
Tailoring of High‐Order Multiple Emulsions by the Liquid–Liquid Phase Separation of Ternary Mixtures (2014)

Abstract Multiple emulsions with an “onion” topology are useful vehicles for drug delivery, biochemical assays, and templating materials. They can be assembled by ternary liquid phase separation by microfluidics, but the control over their design is limited because the mechanism for their creation is unknown. Herein we show that phase separation occurs through self‐similar cycles of mass transfer, spinodal decomposition or nucleation, and coalescence into multiple layers. Mapping out the phase diagram shows a linear relationship between the diameters of concentric layers, the slope of which depends on the initial ternary composition and the molecular weight of the surfactant. These general rules quantitatively predict the number of droplet layers (multiplicity), which we used to devise self‐assembly routes for polymer capsules and liposomes. Moreover, we extended the technique to the assembly of lipid‐stabilized droplets with ordered internal structures.
Reconstruction of Aerosol Properties from Forward-scattering Intensities (2011)

Abstract : This work describes the design and application of an apparatus to image aerosol particles using digital holography in a flowthrough, contact-free manner. Particles in an aerosol stream are illuminated by a triggered, pulsed laser and the pattern produced by the interference of this light with that scattered by the particles is recorded by a digital camera. The recorded pattern constitutes a digital hologram from which an image of the particles is computationally reconstructed using a fast Fourier transform. This imaging is validated using a cluster of ragweed pollen particles. Examples involving mineral-dust aerosols demonstrate the technique's in situ imaging capability for complex-shaped particles over a size range of roughly 15-500 micrometer. The focusing-like character of the reconstruction process is demonstrated using a sodium chloride (NaCl) aerosol particle and is compared to a similar particle imaged with a conventional microscope.
Broadly tunable lasers using color centers (1975)

The potential of certain color centers to make efficient broadly tunable cw lasers for the infrared is discussed. We show how the range 0.9 ≲λ≲3.3 μm can be covered by using FA(II), FB(II) and F+2 centers. The pertinent physics of these centers is reviewed and appropriate laser cavity configurations are discussed. The construction and performance of an advanced FA(II) laser is reported. Finally, the possible use of color centers in distributed feedback devices is discussed.
A High‐Performance Renewable Thermosetting Resin Derived from Eugenol (2014)

A renewable bisphenol, 4,4'-(butane-1,4-diyl)bis(2-methoxyphenol), was synthesized on a preparative scale by a solvent-free, Ru-catalyzed olefin metathesis coupling reaction of eugenol followed by hydrogenation. After purification, the bisphenol was converted to a new bis(cyanate) ester by standard techniques. The bisphenol and cyanate ester were characterized rigorously by NMR spectroscopy and single-crystal X-ray diffraction studies. After complete cure, the cyanate ester exhibited thermal stability in excess of 350 °C and a glass transition temperature (Tg ) of 186 °C. As a result of the four-carbon chain between the aromatic rings, the thermoset displayed a water uptake of only 1.8% after a four day immersion in 85 °C water. The wet Tg of the material (167 °C) was only 19 °C lower than the dry Tg , and the material showed no significant degradation as a result of the water treatment. These results suggest that this resin is well suited for maritime environments and provide further evidence that full-performance resins can be generated from sustainable feedstocks.
Technical Feasibility of Acoustic Coordinated Reset Therapy for Tinnitus Delivered via Hearing Aids: A Case Study (2017)

Primary tinnitus has a severe negative influence on the quality of life of a substantial portion of the general population. When acoustic coordinated reset (CR) neuromodulation stimuli are delivered for several hours per day over several weeks a clinically significant symptom reduction in patients with primary tonal tinnitus has been reported by several clinical sites. Here, we reported the first case where CR neuromodulation was delivered through a hearing aid. A 52-year-old man with chronic primary tonal tinnitus was previously considered untreatable with sound therapy. He initially received the classic CR treatment protocol with signals delivered with the separate proprietary device with his hearing aids removed during treatment. He was subsequently treated with the therapy being deployed through a set of contemporary hearing aids. After 5 months of classic CR treatment with the separate custom device, the THI and VAS<sub>L/A</sub> scores worsened by 57% and 13%/14%, respectively. Using the hearing aid without CR treatment for 5 months no change in tinnitus symptoms was observed. However, after three months of CR treatment delivered through the hearing aids, the THI and VAS<sub>L/A</sub> scores were reduced by 70% and 32%/32%, respectively.
A New Synthesis of Methyl 3-Oxo-2-pentyl-1-cyclopentene-1-acetate (2001)

The 92 : 8 equilibrium mixture of (±)-trans-methyl dihydrojasmonate (1) and its cis-isomer is transformed in 63% overall yield into the title compound 4 by epoxidation of the derived enol acetate 2 with peracetic acid/Na2CO3 in toluene and heating the resulting α-acetoxy epoxide 3 in MeOH in the presence of catalytic amounts of methanesulfonic acid.
Evaluation of FPGA resources for built-in self-test of programmable logic blocks (1996)

We present a new approach for FPGA testing that exploits the reprogrammability of FPGAs to create Built-In Self-Test (BIST) logic only during off-line test. As a result, BIST is achieved without area or performance penalties to the system function implemented by the FPGA, since the FPGA is reconfigured for normal system operation. An analysis of Look-Up Table (LUT) based FGPA architectures yields a general expression for the number of test sessions and establishes the bounds on FPGA logic resources required to minimize the number of BIST configurations required to completely test all of the programmable logic blocks of an FPGA.
Structural Features of Two T-Cell-Specific Genes That Suggest a Potential Role in HTLV-I-Associated Pathology (1993)

The Rpt-1 gene product is an intranuclear protein expressed by CD4+ T-cells, which may regulate expression of the interleukin-2 receptor. Structural analysis of Rpt-1 reveals structural motifs that are shared by a group of transcriptional regulatory proteins with oncogenic potential. We suggest that altered expression of Rpt-1 may be associated with HTLV-I-dependent T-cell leukemias.
.sigma.-Bond metathesis mechanism for dehydropolymerization of silanes to polysilanes by d0 metal catalysts (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.sigma.-Bond metathesis mechanism for dehydropolymerization of silanes to polysilanes by d0 metal catalystsHee Gweon Woo, John F. Walzer, and T. Don TilleyCite this: J. Am. Chem. Soc. 1992, 114, 18, 7047–7055Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/ja00044a015https://doi.org/10.1021/ja00044a015research-articleACS PublicationsRequest reuse permissionsArticle Views1488Altmetric-Citations186LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An intuitive explanation of graph signal processing-based electrical load disaggregation (2017)

Graph Signal Processing (GSP)-based techniques for disaggregation are obtained as a solution of appropriately formulated optimization problem. There is a possibility to work out the intuitive steps behind this solution to gain insights on improvising the existing algorithm and building new ones. In this direction, the paper presents an attempt made to bring out the intuitive explanation of the GSP-based disaggregation solution in a clear manner. Additionally, the promising results obtained by extending the existing GSP-based solution for 15 minutes sampled power data are presented. Also captured are the results towards disaggregating the loads of interest when unknown high power loads are present in the aggregate power data.
Effect of Surface Treatments on the Electrical Properties of (2008)

In this study, different surface treatments of HF-based etching solutions are investigated for the predeposition of liquid-phase deposited fluorinated silicon oxides (LPD-SiOF). The effects of each etching solution on the interface trap density and breakdo wn field are examined with Al/LPD-SiOF/Si structure. From the experimental results, there appears significant growth delay time for different surface treatments during the initial oxide deposition, which is defined as the surface modification time to reach an OHrich surface promoting the growth of LPD-SiOF film. However, the subsequent deposition rate remains unchanged for all etching processes, indicating a surface-independent deposition process. It is found that a two-step treatment in dilute HF/H 2O with 1:200 v/v ratio reveals an average breakdown field of 9.7 MV/cm and an extremely low average interface trap density ( ,10 10 eV 21 cm 22 ), which are comparable to that of thermal oxides. Moreover, the rapid thermal annealing process is suggested to clearly improve the oxide quality for this two-step etching process, where early breakdown is eliminated (18% raising for EBD) and interface properties are substantially improved (33% reduction for DH). The improvements for device performances are believed to be due to the oxide-free Si surface passivated with hydrogen and reduced surface microroughness ( Ra 5 0.1 nm). It is evident from our experiments that this new two-step surface treatment is an effective method for interface improvement with oxide deposited by LPD or chemical vapor deposition.
A single-switch AC-DC converter with power factor correction (2000)

A new single-stage, single-switch power factor correction converter with output electrical isolation is proposed in this paper. The topology of this converter is derived by combining a boost circuit and a forward circuit in one power stage. To improve the performance of the AC-DC converter (i.e., good power factor correction, low total harmonic distortion (THD) and low DC bus voltage), two bulk storage capacitors are adopted. Its excellent line regulation capability makes the converter suitable for universal input application. Due to its simplified power stage and control circuit, this converter presents a better efficiency, lower cost and higher reliability. Detailed steady state analysis and design procedure are presented. To verify the performance of the proposed converter, a design example along with P-simulation program with integrated circuit emphasis (PSPICE) simulation and experimental implementation are given. The measured power factor and efficiency are 99% and 87% at low line (i.e. 110 VAC) operation, and 95% and 81% at high line (i.e. 220 VAC) operation, respectively.
LUSTRE: An Interactive System for Entity Structured Representation and Variant Generation (2018)

Many data analysis and data integration applications need to account for multiple representations of entities. The variations in entity mentions arise in complex ways that are hard to capture using a textual similarity function. More sophisticated functions require the knowledge of underlying structure in the representation of entities. People traditionally identify these structures manually and write programs to manipulate them: such work is tedious and cumbersome. We have built LUSTRE, an active learning based system that can learn the structured representations of entities interactively from a few labels. In the background, it automatically generates programs to map entity mentions to their representations and to standardize them to a unique representation. Furthermore, LUSTRE provides a user-friendly interface to allow user declaratively specify normalization and variant generation functions for downstream applications.
A Metal‐Free N‐Annulated Thienocyclopentaperylene Dye: Power Conversion Efficiency of 12 % for Dye‐Sensitized Solar Cells (2015)

Reported are two highly efficient metal-free perylene dyes featuring N-annulated thienobenzoperylene (NTBP) and N-annulated thienocyclopentaperylene (NTCP), which are coplanar polycyclic aromatic hydrocarbons. Without the use of any coadsorbate, the metal-free organic dye derived from the NTCP segment was used for a dye-sensitized solar cell which attained a power conversion efficiency of 12% under an irradiance of 100 mW cm(-2), simulated air mass global (AM1.5G) sunlight.