gebhart/patrepeval huggingface dataset:
A new C-xylopyranoside derivative induces skin expression of glycosaminoglycans and heparan sulphate proteoglycans. (2007)

Severe structural changes, including deterioration of the mechanical properties of the dermis, occur during skin aging. It is well known that the degradation of the extracellular matrix contributes to the physical changes in aged skin. Whereas many studies have been devoted to age-related alterations of collagen fibrils, far less attention has been paid to another major family of extracellular matrix components, the glycosaminoglycans (GAGs) and proteoglycans (PGs). Heparan sulphate-proteoglycans, (HS-PGs), a subclass of the PG family that decreases during aging, regulate proliferation and proteolysis as well as matrix adhesion and assembly, and thus, may have important functions in skin. These PGs may represent important targets for dermo-cosmetology in fighting skin aging. The purpose of this study was to demonstrate the potential of a new C-xylopyranoside derivative (C-beta-D-xylopyranoside-2-hydroxy-propane simplified as C-Xyloside) to improve HS-PGs expression in human skin. In an organotypical model of corticosteroid atrophic human skin, characterized by a decrease of PGs expression, treatment with C-Xyloside improved expression of HS-PGs.
Novel biomarkers for pre‐diabetes identified by metabolomics (2012)

Type 2 diabetes (T2D) can be prevented in pre-diabetic individuals with impaired glucose tolerance (IGT). Here, we have used a metabolomics approach to identify candidate biomarkers of pre-diabetes. We quantified 140 metabolites for 4297 fasting serum samples in the population-based Cooperative Health Research in the Region of Augsburg (KORA) cohort. Our study revealed significant metabolic variation in pre-diabetic individuals that are distinct from known diabetes risk indicators, such as glycosylated hemoglobin levels, fasting glucose and insulin. We identified three metabolites (glycine, lysophosphatidylcholine (LPC) (18:2) and acetylcarnitine) that had significantly altered levels in IGT individuals as compared to those with normal glucose tolerance, with P-values ranging from 2.4×10(-4) to 2.1×10(-13). Lower levels of glycine and LPC were found to be predictors not only for IGT but also for T2D, and were independently confirmed in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort. Using metabolite-protein network analysis, we identified seven T2D-related genes that are associated with these three IGT-specific metabolites by multiple interactions with four enzymes. The expression levels of these enzymes correlate with changes in the metabolite concentrations linked to diabetes. Our results may help developing novel strategies to prevent T2D.
Ester-carbonate interchange reaction in the solid state: synthesis of poly(ester-carbonate) (1998)

Poly(ethylene terephthalate-co-bisphenol A carbonate) was synthesized by ester-carbonate interchange reaction in the solid state. The polymerization reaction was carried out by heating two chemically distinct oligomers, namely, poly(aryl carbonate) and poly(ethylene terephthalate) in the temperature range of 180–230°C, during which period both chain extension as well as interchange reactions occurred. A copolymer of ηinh = 0.84 dL/g was obtained. With the progress of the interchange reaction the Tg of the copolymer slowly increases and reaches a maximum value of 102°C. The oligomer mixture, which exhibits initially two distinct Tm's, shows a single Tm at the end of the reaction. Formation of copoly(aryl ester-carbonate)s by an ester-carbonate interchange reaction was also found in the solid state at temperatures below 230°C. High molecular weight poly(aryl ester-carbonate)s with a Tg = 163°C and ηinh = 0.52 dL/g were prepared from the corresponding low molecular weight oligomers of poly(aryl ester) and poly(aryl carbonate)s.
On the importance of points-to analysis and other memory disambiguation methods for C programs (2001)

In this paper, we evaluate the benefits achievable from pointer analysis and other memory disambiguation techniques for C/C++ programs, using the framework of the production compiler for the Intel® Itanium™ processor. Most of the prior work on memory disambiguation has primarily focused on pointer analysis, and either presents only static estimates of the accuracy of the analysis (such as average points-to set size), or provides performance data in the context of certain individual optimizations. In contrast, our study is based on a complete memory disambiguation framework that uses a whole set of techniques including pointer analysis. Further, it presents how various compiler analyses and optimizations interact with the memory disambiguator, evaluates how much they benefit from disambiguation, and measures the eventual impact on the performance of the program. The paper also analyzes the types of disambiguation queries that are typically received by the disambiguator, which disambiguation techniques prove most effective in resolving them, and what type of queries prove difficult to be resolved. The study is based on empirical data collected for the SPEC CINT2000 C/C++ programs, running on the Itanium processor.
Metabolism of the Selective Matrix Metalloproteinase-9 Inhibitor (<i>R</i>)-ND-336 (2021)

(<i>R</i>)-ND-336-designated as compound (<i>R</i>)-<b>5</b>-is a highly selective inhibitor of matrix metalloproteinase (MMP)-9 with efficacy in accelerating diabetic wound healing in murine models. (<i>R</i>)-ND-336 belongs to the class of thiirane inhibitors of MMPs and it is currently undergoing Investigation New Drug (IND)-enabling studies. We investigated the <i>in vitro</i> metabolism of (<i>R</i>)-ND-336 using S9 fractions obtained from mice, rats, dogs, minipigs, monkeys, and humans in order to select the rodent and nonrodent species for toxicology studies. Three metabolites were observed. One metabolite, <b>M3</b>, was observed across all species. Metabolite <b>M2</b> was found in rats, monkeys, and humans. Metabolite <b>M1</b> was observed only in rats. The identities of the metabolites were suggested by liquid chromatography/tandem mass spectroscopy (LC/MS-MS) analyses, which were authenticated by comparison to synthetic samples. Metabolites <b>M2</b> and <b>M3</b> arise from oxidative deamination of (<i>R</i>)-ND-336 by monoamine oxidase to give the arylaldehyde as a transient (and unobserved) intermediate. Reductive metabolism of this aldehyde gives the alcohol metabolite <b>M2</b>, while further oxidative metabolism of the aldehyde produces the carboxylate metabolite <b>M3</b>. A minor route of metabolism, seen only in rats, is <i>N</i>-acetylation of (<i>R</i>)-ND-336 to give the acetamide <b>M1</b>. The metabolism of (<i>R</i>)-ND-336 is distinctly different from that of the prototype member of this thiirane class ((±)-<b>1</b>, lacking the 4-aminomethyl aryl substituent) which is metabolized primarily by oxidation α to the sulfone to lead to a benzenesulfinate metabolite. All three metabolites are poorer MMP-9 inhibitors, compared to (<i>R</i>)-ND-336 (MMP-9, <i>K</i> <sub><i>i</i></sub> = 19 nM): <b>M3</b>, MMP-9 IC<sub>50</sub> > 100 μM; <b>M2</b>, <i>K</i> <sub><i>i</i></sub> = 390 nM; and <b>M1</b>, IC<sub>50</sub> > 100 μM). The rat and the minipig were selected as the rodent and nonrodent species, respectively, for toxicology studies.
Efficient adaptation of TTS duration model to new speakers (1998)

This paper discusses a methodology using a minimal set of sentences to adapt an existing TTS duration model to capture interspeaker variations. The assumption is that the original duration database contains information of both language-specific and speaker-specific duration characteristics. In training a duration model for a new speaker, only the speaker-specific information needs to be modeled, therefore the size of the training data can be reduced drastically. Results from several experiments are compared and discussed.
Bioelectronic Tongue Using Heterodimeric Human Taste Receptor for the Discrimination of Sweeteners with Human-like Performance (2014)

The sense of taste helps humans to obtain information and form a picture of the world by recognizing chemicals in their environments. Over the past decade, large advances have been made in understanding the mechanisms of taste detection and mimicking its capability using artificial sensor devices. However, the detection capability of previous artificial taste sensors has been far inferior to that of animal tongues, in terms of its sensitivity and selectivity. Herein, we developed a bioelectronic tongue using heterodimeric human sweet taste receptors for the detection and discrimination of sweeteners with human-like performance, where single-walled carbon nanotube field-effect transistors were functionalized with nanovesicles containing human sweet taste receptors and used to detect the binding of sweeteners to the taste receptors. The receptors are heterodimeric G-protein-coupled receptors (GPCRs) composed of human taste receptor type 1 member 2 (hTAS1R2) and human taste receptor type 1 member 3 (hTAS1R3), which have multiple binding sites and allow a human tongue-like broad selectivity for the detection of sweeteners. This nanovesicle-based bioelectronic tongue can be a powerful tool for the detection of sweeteners as an alternative to labor-intensive and time-consuming cell-based assays and the sensory evaluation panels used in the food and beverage industry. Furthermore, this study also allows the artificial sensor to exam the functional activity of dimeric GPCRs.
CSI feedback based on space-frequency compression (2020)

High-resolution Type II CSI feedback is a key differentiator between 4G (LTE) and 5G (NR). The large feedback overhead of Type II CSI reporting, however, is a bottleneck for UE implementations in real deployments. In this paper, a space-frequency compression based Type II CSI overhead reduction has been proposed. The system-level simulation results are provided to show that the performance similar to Type II CSI is achievable with significantly reduced CSI overhead.
Selective reduction of PVR by inhalation of a cGMP analogue in a porcine model of pulmonary hypertension (1995)

Selective reduction of pulmonary vascular resistance (PVR) remains a therapeutic goal for the treatment of pulmonary hypertension, but current therapeutic options remain limited. Although the gas nitric oxide (NO) selectively dilates the pulmonary vascular bed, it requires special equipment for administration, has a short biologic half-life, and is potentially toxic. We hypothesized that stimulation of the NO pathway at the level of its second messenger, guanosine 3',5'-cyclic monophosphate (cGMP), by targeted pulmonary delivery of a membrane-permeable nonhydrolyzable cGMP analogue would cause selective pulmonary vasodilation. Pulmonary hypertension was induced in 21 pigs by the intravenous infusion of a thromboxane A2 analogue (9,11-dideoxy-9 alpha,11 alpha-epoxymethanoprostaglandin F2 alpha). Inhaled 8-bromoguanosine 3',5'-cyclic monophosphate (8-BrcGMP) lowered PVR in a time- and dose-dependent manner, with maximal effect achieved after 20 min. Compared with physiological saline control, 8-BrcGMP inhalation (3.0 micrograms/kg) lowered PVR by 25 +/- 3% (P < 0.01), whereas there was no significant decline in systemic vascular resistance (4 +/- 6%); mean pulmonary arterial pressure declined 13 +/- 3% (P < 0.01), whereas there was little change in mean arterial pressure; cardiac output increased 10 +/- 4% (P < 0.05). PVR did not decrease after inhalation of noncyclic 8-bromoguanosine 5'-monophosphate, indicating that stimulation of the NO-cGMP pathway beyond the level of NO results in pulmonary vasodilation independent of stimulation of purinergic receptors.(ABSTRACT TRUNCATED AT 250 WORDS)
Single-molecule packaging initiation in real time by a viral DNA packaging machine from bacteriophage T4 (2014)

Viral DNA packaging motors are among the most powerful molecular motors known. A variety of structural, biochemical, and single-molecule biophysical approaches have been used to understand their mechanochemistry. However, packaging initiation has been difficult to analyze because of its transient and highly dynamic nature. Here, we developed a single-molecule fluorescence assay that allowed visualization of packaging initiation and reinitiation in real time and quantification of motor assembly and initiation kinetics. We observed that a single bacteriophage T4 packaging machine can package multiple DNA molecules in bursts of activity separated by long pauses, suggesting that it switches between active and quiescent states. Multiple initiation pathways were discovered including, unexpectedly, direct DNA binding to the capsid portal followed by recruitment of motor subunits. Rapid succession of ATP hydrolysis was essential for efficient initiation. These observations have implications for the evolution of icosahedral viruses and regulation of virus assembly.
Maternal Response to Paternal Trophoblast Antigens (1997)

R80K protein is a target molecule for NK cell activity expressed on all placentae. It has a polymorphic alloantigenic determinant completely covered with maternal antibody in all successful term pregnancies. In murine NK cell-dependent models of abortion, a mAb against a monomorphic determinant present in human and murine R80K prevents abortion very effectively. It seems that the R80K molecule must be covered with antibody to prevent NK attacks on trophoblast.
Wireless interrogation of passive antenna sensors (2010)

Recently, we discovered that the resonant frequency of a microstrip patch antenna is sensitive to mechanical strains or crack presence in the ground plane. Based on this principle, antenna sensors have been demonstrated to measure strain and detect crack in metallic structures. This paper presents a wireless method to remotely interrogate a dual-frequency antenna sensor. An interrogation horn antenna was used to irradiate the antenna sensor with a linear chirp microwave signal. By implementing a light-activated switch at the sensor node and performing signal processing of the backscattered signals, the resonant frequencies of the antenna sensor along both polarizations can be measured remotely. Since the antenna sensor does not need a local power source and can be interrogated wirelessly, electric wiring can be eliminated. The sensor implementation, the signal processing and the experimental setup that validate the remote interrogation of the antenna sensor are presented. A power budget model has also been established to estimate the maximum interrogation range.
Assembly of Magnetically Tunable Photonic Crystals in Nonpolar Solvents (2009)

We have successfully assembled superparamagnetic colloids into ordered structures with magnetically tunable photonic properties in nonpolar solvents by establishing long-range electrostatic repulsive forces using charge control agents. Reverse micelles resulted from the introduction of charge control agents such as AOT molecules can enhance the charge separation on the surfaces of n-octadecyltrimethoxysilane modified Fe(3)O(4)@SiO(2) particles. The significantly improved long-range electrostatic repulsion can counterbalance the magnetically induced attraction and therefore allow ordering of superparamagnetic colloids in nonpolar solvents. This system possesses a fast and fully reversible optical response to the external magnetic fields, long-term stability in performance, and good diffraction intensity.
Practical multispectral lighting reproduction (2016)

We present a practical framework for reproducing omnidirectional incident illumination conditions with complex spectra using a light stage with multispectral LED lights. For lighting acquisition, we augment standard RGB panoramic photography with one or more observations of a color chart with numerous reflectance spectra. We then solve for how to drive the multispectral light sources so that they best reproduce the appearance of the color charts in the original lighting. Even when solving for non-negative intensities, we show that accurate lighting reproduction is achievable using just four or six distinct LED spectra for a wide range of incident illumination spectra. A significant benefit of our approach is that it does not require the use of specialized equipment (other than the light stage) such as monochromators, spectroradiometers, or explicit knowledge of the LED power spectra, camera spectral response functions, or color chart reflectance spectra. We describe two simple devices for multispectral lighting capture, one for slow measurements of detailed angular spectral detail, and one for fast measurements with coarse angular detail. We validate the approach by realistically compositing real subjects into acquired lighting environments, showing accurate matches to how the subject would actually look within the environments, even for those including complex multispectral illumination. We also demonstrate dynamic lighting capture and playback using the technique.
Binary Corrosion Inhibitors Offer Improved Corrosion Control (2005)

Summary An improvement has been made in anticorrosion chemicals for oilfield use. A binary corrosion inhibitor that combines an epoxy resin and an amine curing agent has been patented and field proven. The proper application of this unique combination of chemicals forms a bond with the oxide film present on downhole metal surfaces. The result is a corrosion-inhibitor barrier that is more tenacious than conventional polar-filming amines, reducing application frequency and labor costs and, even more important, downhole failures. The binary corrosion inhibitor is also an improvement over, and is more versatile than, other epoxy-amine products.
Design of visible light communication system for maintaining uniform data rate (2014)

Light-emitting diode (LED) is gradually replacing the fluorescent lamp for lighting. Higher modulation bandwidth of LEDs makes the additional application of visible light communication (VLC) possible. Every location of a VLC system should be provided by equal data rate for smooth communication. However, locations away from the LED lamp have less power. These low-power locations have lower signal-to-noise ratio (SNR); and hence lower data rate can be achieved. For achieving high capacity VLC, strategies should be adequately provided to mitigate this problem. Moreover, for some real-time continuous applications, such as video and voice, latency reduction plan should also be considered. In this paper, an orthogonal frequency-division multiplexing access (OFDMA) based system was proposed to solve the above problem. Because we do not use time-division multiplexing access (TDMA) based system, the latency issue can be reduced. The OFDMA based system is also beneficial for large scale operation because the user bandwidth is not reduced by TDM mechanism. Signal-to-noise-plus-interference ratio (SNIR) distribution of the VLC system is designed to ensure uniform and optimal system capacity. Discrete multi-tone (DMT) is used for this VLC system. The DMT subcarriers are bit-loaded depending on the LED frequency response. More subcarriers are allocated for communication at low SNIR locations. Hence, nearly equal data rate can be provided everywhere. Demonstration of 17 Mb/s/LED data rate was provided.
Unknown Arbitrary Phase Shift Retrieval and Holographic Reconstruction from Images Obtained from Self-Interference Incoherent Digital Holography (2013)

The algorithm to retrieve the phase shift from the image recorded using the self-interference incoherent digital holography is proposed. Using the proposed algorithm, the complex hologram can be retrieved with unknown and arbitrary phase shift.
Active stabilization for optically synchronized optical parametric chirped pulse amplification (2012)

The development of new high power laser sources tends toward optical parametric chirped pulse amplification (OPCPA) in recent years. One of the difficulties in OPCPA is the the temporal overlap between pump and seed pulses. In this work we characterize our timing jitter on a single-shot basis using spectrally resolved cross-correlation in combination with a position sensitive detector. A commercial beam stabilization is adapted to actively enhance temporal overlap. This delay-stabilizer reduces the RMS jitter from σ = 127 fs down to σ = 24 fs. The enhanced temporal overlap is demonstrated in our frontend and we propose the scheme to be applicable in many optically synchronized high-repetition-rate OPCPA systems.
Effect of daclizumab high-yield process in patients with highly active relapsing-remitting multiple sclerosis (2013)

Patients with highly active relapsing-remitting multiple sclerosis (RRMS) are at greater risk for disease progression and may respond differently to MS therapeutics than those with less active disease. The current post hoc analysis evaluated the effects of daclizumab high-yield process (DAC HYP) vs. placebo in patients with highly active RRMS in the SELECT study. Highly active RRMS was defined as patients with ≥2 relapses in the year before randomization and ≥1 gadolinium-enhancing (Gd(+)) lesion at baseline. Because results were similar in the DAC HYP dose groups, data from the DAC HYP arms were pooled for analysis. Treatment with DAC HYP resulted in similar effects in highly active (n = 88) and less active (n = 506) RRMS patients. DAC HYP reduced the annualized relapse rate by 50 % and 51 % in the highly active (p = 0.0394) and less active (p < 0.0001) groups vs. placebo, respectively (interaction p = 0.82). DAC HYP reduced new/newly-enlarging T2 lesions (highly active RRMS 76 % reduction, p < 0.0001; less active RRMS 73 % reduction, p < 0.0001; interaction p = 0.18), the risk of having more Gd(+) lesions (highly active RRMS 89 % reduction, p < 0.0001; less active RRMS 86 % reduction, p < 0.0001; interaction p = 0.46), and sustained disability progression (highly active RRMS 88 % reduction, p = 0.0574; less active RRMS 46 % reduction, p = 0.0383; interaction p = 0.22) vs. placebo. DAC HYP efficacy was similar across the spectrum of MS disease activity as assessed prior to treatment initiation.
Eye Gaze for Spoken Language Understanding in Multi-modal Conversational Interactions (2014)

When humans converse with each other, they naturally amalgamate information from multiple modalities (i.e., speech, gestures, speech prosody, facial expressions, and eye gaze). This paper focuses on eye gaze and its combination with speech. We develop a model that resolves references to visual (screen) elements in a conversational web browsing system. The system detects eye gaze, recognizes speech, and then interprets the user's browsing intent (e.g., click on a specific element) through a combination of spoken language understanding and eye gaze tracking. We experiment with multi-turn interactions collected in a wizard-of-Oz scenario where users are asked to perform several web-browsing tasks. We compare several gaze features and evaluate their effectiveness when combined with speech-based lexical features. The resulting multi-modal system not only increases user intent (turn) accuracy by 17%, but also resolves the referring expression ambiguity commonly observed in dialog systems with a 10% increase in F-measure.