gebhart/patrepeval huggingface dataset:
MiR-126 Contributes to Human Umbilical Cord Blood Cell-Induced Neurorestorative Effects After Stroke in Type-2 Diabetic Mice (2015)

Diabetes mellitus (DM) is a high risk factor for stroke and leads to more severe vascular and white-matter injury than stroke in non-DM. We tested the neurorestorative effects of delayed human umbilical cord blood cell (HUCBC) treatment of stroke in type-2 diabetes (T2DM). db/db-T2DM and db/+-non-DM mice were subjected to distal middle cerebral artery occlusion (dMCAo) and were treated 3 days after dMCAo with: (a) non-DM + Phosphate buffered saline (PBS); (b) T2DM + PBS; (c) T2DM + naïve-HUCBC; (d) T2DM + miR-126(-/-) HUCBC. Functional evaluation, vascular and white-matter changes, neuroinflammation, and miR-126 effects were measured in vivo and in vitro. T2DM mice exhibited significantly decreased serum and brain tissue miR-126 expression compared with non-DM mice. T2DM + HUCBC mice exhibited increased miR-126 expression, increased tight junction protein expression, axon/myelin, vascular density, and M2-macrophage polarization. However, decreased blood-brain barrier leakage, brain hemorrhage, and miR-126 targeted gene vascular cell adhesion molecule-1 and monocyte chemotactic protein 1 expression in the ischemic brain as well as improved functional outcome were present in HUCBC-treated T2DM mice compared with control T2DM mice. MiR-126(-/-) HUCBC-treatment abolished the benefits of naïve-HUCBC-treatment in T2DM stroke mice. In vitro, knock-in of miR-126 in primary cultured brain endothelial cells (BECs) or treatment of BECs with naïve-HUCBCs significantly increased capillary-like tube formation, and increased axonal outgrowth in primary cultured cortical neurons; whereas treatment of BECs or cortical neurons with miR-126(-/-) HUCBC attenuated HUCBC-treatment-induced capillary tube formation and axonal outgrowth. Our data suggest delayed HUCBC-treatment of stroke increases vascular/white-matter remodeling and anti-inflammatory effects; MiR-126 may contribute to HUCBC-induced neurorestorative effects in T2DM mice.
Transsexuals and the Family Medical Leave Act, 24 J. Marshall J. Computer & Info. L. 315 (2006) (2006)

This article examines the implications for transsexuals seeking sexual reassignment surgery (“SRS”) under the Family Medical Leave Act (“FMLA”). Currently, the scant case law pertaining to the FMLA suggests that the statutes and regulations will likely fail to provide even minimal protection to transsexuals. If applied literally, the FMLA may present barriers to transsexuals seeking SRS in opposition to the true purpose behind the Act, which is to allow employees the opportunity to take reasonable leave from work by mandating more medical leave than the employers might otherwise be willing to grant for things such as the adoption or birth of a child, care of a closely related family member, or for serious health conditions. For example, SRS may fail to constitute a “serious health condition” as defined by the Act, or SRS could be characterized as a cosmetic surgery, which is specifically excluded from the Act. As a result, transsexuals would be denied coverage under the FMLA and prevented from proceeding with the necessary procedures for transsexuals to conform to their gender identity. In response, this article suggests that courts and employers should consider a more flexible approach for transsexuals seeking FMLA leave for SRS in order to afford deference to transsexuals’ constitutional rights and privacy interests. This construction would further the goal of the FMLA by providing job security to transsexual, would benefit employers and society at large by fostering a better understanding of the transsexual experience, and would mark yet another step towards equality for all.
Ethylene Diamine Tetraacetic Acid Etched Quantum Dots as a “Turn-On” Fluorescence Probe for Detection of Trace Zinc in Food (2016)

In the present paper, a simple and rapid "turn-on" fluorescence sensor for Zn2+ based on ethylene diamine tetraacetic acid (EDTA) etched CdTe quantum dots (QDs) was developed. First, the initial bright fluorescence of mercaptopropionic acid (MPA) capped CdTe QDs was effectively quenched by EDTA, and then the presence of Zn2+ could "turn on" the weak fluorescence of QDs quenched by EDTA due to the formation of ZnS passivation shell. The increase of fluorescence intensity of EDTA etched QDs was found to be linear with the concentration of Zn2+ added. Under the optimum conditions, the calibration curve of this method showed good linearity in the concentration range of 9.1-1 09.1 μM of Zn2+ with the correlation coefficient R2 = 0.998. The limit of detection (3σ/K) was 2 μM. The developed QDs-based sensor was successfully applied to detect trace zinc in zinc fortified table salts and energy drinks with satisfactory results.
Poststroke Sonic Hedgehog Agonist Treatment Improves Functional Recovery by Enhancing Neurogenesis and Angiogenesis (2017)

These data confirm an important role for the hedgehog pathway in poststroke brain repair and functional recovery, suggesting a prolonged treatment window for potential treatment strategy to modulate sonic hedgehog pathway after stroke.
L'optimisation des amplificateurs de puissance a excitation d'entree sinusoidale en vue de leur rendement electrique et de leur linearite (1995)

Le travail de these presente traite des phenomenes non-lineaires des amplificateurs de puissance a excitation d'entree sinusoidale, dans l'objectif d'une optimisation du rendement electrique d'une part, et de la recherche systematique des conditions de fonctionnement particulieres permettant d'atteindre des compromis linearite/rendement interessants d'autre part. Or, une attention particuliere a ete portee a l'amelioration du rendement electrique du composant actif par la mise en evidence des resistances de sortie appropriees a lui presenter a la frequence fondamentale et aux frequences harmoniques, afin d'obtenir des tensions de sortie ayant des formes d'onde particulieres. En considerant un fonctionnement du transistor dans une classe de fonctionnement classique (a, ab et b), la premiere partie du memoire de these montre l'influence du point de repos sur les principales grandeurs electriques du transistor telles que la puissance de sortie, le gain en puissance et le rendement electrique. Cette premiere partie montre aussi l'influence des pertes du filtre de sortie sur le rendement electrique ainsi que la possibilite d'augmenter le rendement electrique du transistor par la mise en forme de la tension de sortie en classe f. La deuxieme partie du memoire de these traite les distorsions non-lineaires du signal de sortie du transistor telles que les conversions am/am et am/pm et l'intermodulation d'ordre trois. Cette etude montre, entre autres, une correlation etroite entre le minimum des distorsions non-lineaires et l'annulation de la composante de courant de drain a la frequence harmonique trois. Ceci nous a permis de determiner les points de fonctionnement qui se pretent particulierement bien pour realiser des compromis linearite/rendement interessants. Ces trois parties theoriques ont ete completees par la conception et la realisation de quatre amplificateurs de puissance integres et d'un amplificateur de puissance hybride travaillant en classe f avec un rendement en puissance ajoutee de 74%
New Rapamycin Derivatives by Precursor‐Directed Biosynthesis (2004)

Possible new immunosuppressants through biosynthesis: Derivatives of the immunosuppressant rapamycin, such as analogue 3, are obtained by feeding simple carboxylic acids to the rapamycin-producing organism. Incorporation of these alternative starter units appears to be preceded by their specific hydroxylation. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2004/z758_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Dimension increase in filtered chaotic signals (1988)

An increase in fractal dimension is shown to occur in filtered chaotic signals. The dependence of the Lyapunov dimension on the filter parameters is used to predict the behavior of the information dimension which is directly evaluated for two experimental systems: the NMR laser and Rayleigh-B\'enard convection. Good quantitative agreement with the theoretical predictions is found. The understanding of the role of filtering not only clarifies aspects relevant in the calculation of fractal dimensions, but also yields an indirect but precise way of evaluating Lyapunov exponents.
3D optical see-through head-mounted display based augmented reality system and its application (2015)

The combination of health and entertainment becomes possible due to the development of wearable augmented reality equipment and corresponding application software. In this paper, we implemented a fast calibration extended from SPAAM for an optical see-through head-mounted display (OSTHMD) which was made in our lab. During the calibration, the tracking and recognition techniques upon natural targets were used, and the spatial corresponding points had been set in dispersed and well-distributed positions. We evaluated the precision of this calibration, in which the view angle ranged from 0 degree to 70 degrees. Relying on the results above, we calculated the position of human eyes relative to the world coordinate system and rendered 3D objects in real time with arbitrary complexity on OSTHMD, which accurately matched the real world. Finally, we gave the degree of satisfaction about our device in the combination of entertainment and prevention of cervical vertebra diseases through user feedbacks.
Data2Vis: Automatic Generation of Data Visualizations Using Sequence-to-Sequence Recurrent Neural Networks (2019)

Rapidly creating effective visualizations using expressive grammars is challenging for users who have limited time and limited skills in statistics and data visualization. Even high-level, dedicated visualization tools often require users to manually select among data attributes, decide which transformations to apply, and specify mappings between visual encoding variables and raw or transformed attributes. In this paper we introduce Data2Vis, an end-to-end trainable neural translation model for automatically generating visualizations from given datasets. We formulate visualization generation as a language translation problem, where data specifications are mapped to visualization specifications in a declarative language (Vega-Lite). To this end, we train a multilayered attention-based encoder-decoder network with long short-term memory (LSTM) units on a corpus of visualization specifications. Qualitative results show that our model learns the vocabulary and syntax for a valid visualization specification, appropriate transformations (count, bins, mean), and how to use common data selection patterns that occur within data visualizations. We introduce two metrics for evaluating the task of automated visualization generation (language syntax validity, visualization grammar syntax validity) and demonstrate the efficacy of bidirectional models with attention mechanisms for this task. Data2Vis generates visualizations that are comparable to manually created visualizations in a fraction of the time, with potential to learn more complex visualization strategies at scale.
Characterizing the diversity of active bacteria in soil by comprehensive stable isotope probing of DNA and RNA with H<sub>2</sub><sup>18</sup>O (2015)

Current limitations in culture-based methods have lead to a reliance on culture-independent approaches, based principally on the comparative analysis of primary semantides such as ribosomal gene sequences. DNA can be remarkably stable in some environments, so its presence does not indicate live bacteria, but extracted ribosomal RNA (rRNA) has previously been viewed as an indicator of active cells. Stable isotope probing (SIP) involves the incorporation of heavy isotopes into newly synthesized nucleic acids, and can be used to separate newly synthesized from existing DNA or rRNA. H<sub>2</sub><sup>18</sup> O is currently the only potential universal bacterial substrate suitable for SIP of entire bacterial communities. The aim of our work was to compare soil bacterial community composition as revealed by total versus SIP-labeled DNA and rRNA. Soil was supplemented with H<sub>2</sub><sup>18</sup> O and after 38 days the DNA and RNA were co-extracted. Heavy nucleic acids were separated out by CsCl and CsTFA density centrifugation. The 16S rRNA gene pools were characterized by DGGE and pyrosequencing, and the sequence results analyzed using mothur. The majority of DNA (~60%) and RNA (~75%) from the microcosms incubated with H<sub>2</sub><sup>18</sup> O were labeled by the isotope. The analysis indicated that total and active members of the same type of nucleic acid represented similar community structures, which suggested that most dominant OTUs in the total nucleic acid extracts contained active members. It also supported that H<sub>2</sub><sup>18</sup> O was an effective universal label for SIP for both DNA and RNA. DNA and RNA-derived diversity was dissimilar. RNA from this soil more comprehensively recovered bacterial richness than DNA because the most abundant OTUs were less numerous in RNA than DNA-derived community data, and dominant OTU pools didn't mask rare OTUs as much in RNA.
Synthesis and evaluation of fluorescent materials for colour control of peroxyoxalate chemiluminescence. II. Violet and blue emitters (1981)

Synthetic approaches to efficient blue fluorescent compounds suitable for use in peroxyoxalate chemiluminescence systems are described. Various bis(phenylethynyl)-naphthalenes and -phenan-threnes were obtained but these were shown to produce purple fluorescence and chemiluminescence. Ring substitution of 9,10-diphenylanthracene, however, afforded a number of satisfactory blue fluorescent emitters. The structure and derivation of several byproducts is also discussed.
Shopper Marketing: How to Increase Purchase Decisions at the Point of Sale (2012)

Chapter - 22: Marketing as a crucial part of retailer partnership - Antti Syvaniemi Chapter - 23: Touching the elephant - Chris Hoyt Chapter - 24: Future shock - Ken Barnett Chapter - 25: Shopper marketing's true potential - Dan Flint Chapter - 26: Putting the shopper in your shopper marketing strategy - Matt Nitzberg Section - THREE: What is shopper marketing in action? Chapter - 27: Improving shopper marketing profitability with innovative promotions - Markus Stahlberg Chapter - 28: The circle of shopper marketing mechanization - Dick Blatt Chapter - 29: Nestle Rossiya, Russia - Lubov Kelbakh Chapter - 30: Connected shoppers are here, now - but how do you connect with them? - Jason Rogers Chapter - 31: Tesco Fresh & Easy, USA - Simon Uwins Chapter - 32: Shopper-oriented pricing strategies - Jon Hauptman Chapter - 33: Packaging can be your best investment - Russ Napolitano Chapter - 34: The real power of brands in the digital world: what marketers must know about the online shopping decision process - Juliano Marcilio Chapter - 35: 'Too many choices' - and their implications for package design - Scott Young Chapter - 36: Maximizing ROI of package promotions - Ville MailaChapter - 21: Shopper promotions: what can marketers learn from price discounts - Markus Stahlberg Chapter - 20: Capitalize on unrealized demand among shoppers - Al Wittemen Chapter - 19: The missing link: turning shopper insight into practice - Toon van Galen Chapter - 18: Bridging gaps: retail in the emerging Indian market - Dheeraj Sinha Chapter - 17: Ensuring your brand gets on the shopping list - Robert Levy Chapter - 16: Internationalization of shopper marketing - Ville Maila Chapter - 15: The conversion model for shopper research - Clemens Steckner Chapter - 14: Integrated communications planning for shopper marketing - David Sommer Chapter - 13: Retail media: a catalyst for shopper marketing - Gwen Morrison Chapter - 12: Tailing your shoppers: retailing for the future - AnnaMaria M Turano Chapter - 11: Connecting, engaging and exciting shoppers - Michael Morrison and Meg Mundell Section - TWO: Strategy: how to approach shopper marketing Chapter - 10: The shopping motives of Chinese shoppers - Kevin Mu Chapter - 09: The three shopping currencies - Herb Sorensen Chapter - 08: For shoppers there's no place like home - Harvey Hartman Chapter - 07: Illogic inside the mind of the shopper - Michael Sansolo Chapter - 06: Science of shopping - Gopi Krishnaswamy Chapter - 05: Bringing shopper into category management - Brian Harris Chapter - 04: Seven steps towards effective shopper marketing - Luc Desmedt Chapter - 03: Shopper marketing: the discipline, the approach - Jim Lucas Chapter - 02: Point of view on shopper marketing - Gordon Pincott Chapter - 01: Science of shopping - Paco Underhill Section - ONE: Definition: what is shopper marketing? Chapter - 00: Introduction
Dual Interferometric-Doppler Measurements of the Radial and Angular Velocity of Humans (2014)

The first measurements of moving humans using a dual-mode millimeter-wave radar sensor are presented. The radar sensor is comprised of a Doppler detection mode for measuring the radial velocity of a moving object, as well as a recently developed interferometric mode for directly measuring the angular velocity. Combining the two detection modes, it is shown that the motion of a walking human can be detected and measured regardless of the direction of trajectory relative to the radar sensor. Such a capability has the potential to significantly improve the effectiveness of security radars, and may apply to a broad range of other motion detection radar applications. The frequency shifts imparted on the signal in both Doppler and interferometric detection modes are measured in the time-frequency domain, and show that as the trajectory moves from a completely radial motion to a completely angular motion, the Doppler frequency shift decreases while the interferometric frequency shift increases. The two detection modes therefore represent complementary measurements, improving the ability to measure the motion of randomly moving objects.
Automation of Mud-Pump Management: Application to Drilling Operations in the North Sea (2011)

Summary Drilling in the North Sea is confronted with an ever more challenging pressure-management issue because of narrow geopressure windows in depleted reservoirs. Further, the occurrence of packoffs can cause serious damage to the formation and contribute to nonproductive time. To address these problems, automation of mud-pump management has been developed over the last 4 years to minimize the chance of fracturing the formation while starting the mud pumps or circulating. To account for abnormal flow restrictions in the annulus, automatic actions are also an integral part of the mud-pump automation described in this paper. Since the downhole conditions are continuously changing (e.g., depth, temperature, flow-rate, gel time, cuttings proportion), the necessary safeguards to operate the mud pumps need to be updated constantly. Advanced transient temperature and hydraulic models are used to estimate, in real-time, the downhole situation. On the basis of the current context, evaluations of maximum pump rates and acceptable flow accelerations are performed and sent to the mud-pump control system to be used as an envelope of protection. Furthermore, to assist the driller during connections, the pump-startup procedure has been semiautomated to decrease connection time. Finally, an automatically triggered pump-shutdown procedure is also available to minimize the consequences of a packoff on formation fracturing. A first version of the system has been tested during the drilling of one well in 2008 in the North Sea. Based on the initial experience, a revised version has been used during the drilling of three wells drilled on the Norwegian continental shelf in 2009. The feedback from the drillers involved in the testing has been used to improve the user friendliness of the system. The automation of the mud-pump management has been well accepted by the drilling crews. However, the testing has shown that additional instrumentation at the rigsite is necessary before such automation can be rolled out safely.
Cyclophilin A Renders Human Immunodeficiency Virus Type 1 Sensitive to Old World Monkey but Not Human TRIM5α Antiviral Activity (2006)

TRIM5alpha is an important mediator of antiretroviral innate immunity influencing species-specific retroviral replication. Here we investigate the role of the peptidyl prolyl isomerase enzyme cyclophilin A in TRIM5alpha antiviral activity. Cyclophilin A is recruited into nascent human immunodeficiency virus type 1 (HIV-1) virions as well as incoming HIV-1 capsids, where it isomerizes an exposed proline residue. Here we show that cyclophilin A renders HIV-1 sensitive to restriction by TRIM5alpha in cells from Old World monkeys, African green monkey and rhesus macaque. Inhibition of cyclophilin A activity with cyclosporine A, or reducing cyclophilin A expression with small interfering RNA, rescues TRIM5alpha-restricted HIV-1 infectivity. The effect of cyclosporine A on HIV-1 infectivity is dependent on TRIM5alpha expression, and expression of simian TRIM5alpha in permissive feline cells renders them able to restrict HIV-1 in a cyclosporine A-sensitive way. We use an HIV-1 cyclophilin A binding mutant (CA G89V) to show that cyclophilin A has different roles in restriction by Old World monkey TRIM5alpha and owl monkey TRIM-Cyp. TRIM-Cyp, but not TRIM5alpha, recruits its tripartite motif to HIV-1 capsid via cyclophilin A and, therefore, HIV-1 G89V is insensitive to TRIM-Cyp but sensitive to TRIM5alpha. We propose that cyclophilin A isomerization of a proline residue in the TRIM5alpha sensitivity determinant of the HIV-1 capsid sensitizes it to restriction by Old World monkey TRIM5alpha. In humans, where HIV-1 has adapted to bypass TRIM5alpha activity, the effects of cyclosporine A are independent of TRIM5alpha. We speculate that cyclophilin A alters HIV-1 sensitivity to a TRIM5alpha-independent innate immune pathway in human cells.
Indications and limitations of Er:YAG laser applications in dentistry. (2006)

Based on the synthesis of the reviewed literature different topics concerning the Er:YAG effects and applications in dentistry are discussed and recommendations for the use of this type of laser are given.
Design for Quality in the Shipbuilding Industry (1993)

There is a growing understanding that the quality of a product should be built in at the design phase. More and more reports have shown that this kind of approach, named design for quality, can benefit the company to make it much more competitive. In many Eastern countries such as Japan and Taiwan, such concepts have been used for a while. The so‐called product oriented design (POD) and quality function deployment (QFD) are widely used in many industries. This may be one of the main reasons why many Eastern countries have had a very high economic growth rate during the past two decades. For a coastal nation, the shipbuilding industry is essential for defence purposes. However, to run a shipyard efficiently is not an easy job due to several of its characteristics. They are: (1) the product (a ship) size is very large both in volume and weight and each product has thousands of different components; (2) the design, planning and manufacturing process overlap very significantly and the concept of “teamwork” is therefore greatly emphasized; and (3) the production process is very complex and complicated with very many interdependences. With these characteristics, the methods of “design for quality” and “design for manufacture” seem to be ideal tools for the shipbuilding industry to maintain product quality while raising the shipyard′s efficiency. Describes how a shipbuilding company in Taiwan can apply these positive concepts to improve its performance. Discusses several practical examples to illustrate these concepts.