gebhart/patrepeval huggingface dataset:
Interoperability Strategic Vision (2018)

The Interoperability Strategic Vision whitepaper aims to promote a common understanding of the meaning and characteristics of interoperability and to provide a strategy to advance the state of interoperability as applied to integration challenges facing grid modernization. This includes addressing the quality of integrating devices and systems and the discipline to improve the process of successfully integrating these components as business models and information technology improve over time. The strategic vision for interoperability described in this document applies throughout the electric energy generation, delivery, and end-use supply chain. Its scope includes interactive technologies and business processes from bulk energy levels to lower voltage level equipment and the millions of appliances that are becoming equipped with processing power and communication interfaces. A transformational aspect of a vision for interoperability in the future electric system is the coordinated operation of intelligent devices and systems at the edges of grid infrastructure. This challenge offers an example for addressing interoperability concerns throughout the electric system.
A Clinical Trial of Injectable Testosterone Undecanoate as a Potential Male Contraceptive in Normal Chinese Men (1999)

This is a pilot dose-finding study of spermatogenic suppression using\n testosterone undecanoate (TU) injections alone in normal Chinese men.\n Thirty-two healthy men were recruited. Volunteers underwent pretreatment\n evaluation, then a treatment period in which group I (n = 13) received 500\n mg TU, group II (n = 12) received 1000 mg TU, and group III (n = 7)\n received placebo, respectively, at monthly intervals during the treatment\n period (or until azoospermia was achieved). Thereafter, they underwent a\n recovery period until all parameters returned to pretreatment levels.\n Eleven of 12 volunteers in the 500-mg TU group, and all volunteers in the\n 1000-mg TU group became azoospermic. Faster suppression of spermatogenesis\n was achieved in the 1000-mg TU group. Serum testosterone increased\n significantly in the higher dose group at weeks 8 and 12, but remained\n within the normal range. Mean serum LH and FSH were profoundly suppressed\n by both doses to undetectable levels at week 16. TU injections did not\n cause a significant change in high density lipoprotein cholesterol levels.\n No serious side-effects were found. We conclude that both dosages of TU\n can effectively, safely, and reversibly suppress spermatogenesis in normal\n Chinese men.
Electrochemical Performance of Natural Graphite by Surface Modification Using Aluminum (2001)

We investigated electrochemical performance of natural graphite surface-treated with aluminum compared to that of untreated graphite. Aluminum triethoxide was used as the treatment source. In the treatment process, the drying temperature has critical influence on electrochemical performance of the treated samples. The surface property of treated samples was investigated by scanning electron microscopy and Raman spectroscopy. The vibration mode of the treated sample was sharpened and shifted upward, whereas no remarkable changes were found in mode. The electrochemical performance improved markedly with Al treatment. The impedance measurement shows that the Al treated sample had much smaller charge-transfer resistance during cycling. © 2001 The Electrochemical Society. All rights reserved.
miR-526b-3p functions as a tumor suppressor in colon cancer by regulating HIF-1α. (2016)

HIF-1α is an important transcriptional factor, which plays roles in cancer development and progression. But its regulation by miRNAs is not clear. Here, to investigate the regulation of HIF-1α by miRNAs, miRNAs were predicted and miR-526b-3p was verified as a regulator of HIF-1α in colon cancer cells. Using TaqMan RT-PCR analysis, we analyzed the expression of miR-526b-3p in tumor tissues and cell lines and found that miR-526b-3p was consistently under-expressed in cancer tissues and cell lines compared with their normal controls. When miR-526b-3p was induced into the colon cancer cells, cell proliferation, metastasis and glycolysis of colon cancer cells were suppressed. We also found that miR-526b-3p was down-regulated in metastatic colon cancer tissues and negatively with HIF-1α mRNA in colon cancer tissues. In a summary, miR-526b-3p plays as a tumor suppressor by down-regulation of HIF-1α expression in colon cancer and may be a new diagnosis or therapeutic target.
Time-reversed Lasing and Control of Absorption in a Two-channel Coherent Perfect Absorber (2011)

We demonstrate a novel mechanism for controlling absorption of coherent light bytwo orders of magnitude. By varying the phase of incident laser light in a two-port geometry, the absorption is greatly enhanced or reduced.
Preparation of Inorganic–Organic Nanocomposites through Intercalation of Organoammonium Ions into Layered Silicates (1997)

Abstract Recent developments in the study of the intercalation of organoammonium ions into layered silicates are reviewed. The new developments of the applications of the organoammonium-exchanged layered silicates include the selective adsorption of toxic compounds from water, the immobilization of photo and electroactive species to construct novel photo and electrofunctional materials, and the complexation with organic polymers for the enhancement of the mechanical properties. The conversion of the layered solids to three dimensional nanoporous solids with novel microstructures and adsorptive properties has also been successfully done. The novel controlled properties achieved by the modification with the adsorption of organoammonium ions open new opportunities to tailor the properties of the inorganic-organic nanostructured materials.
Amplification of biological targets via on-chip culture for biosensing (2023)

The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.
Betaglycan has Two Independent Domains Required for High Affinity TGF-β Binding: Proteolytic Cleavage Separates the Domains and Inactivates the Neutralizing Activity of the Soluble Receptor (2009)

Betaglycan is a coreceptor for members of the transforming growth factor beta (TGF-beta) superfamily. Mutagenesis has identified two ligand binding regions, one at the membrane-distal and the other at the membrane-proximal half of the betaglycan ectodomain. Here we show that partial plasmin digestion of soluble betaglycan produces two proteolysis-resistant fragments of 45 and 55 kDa, consistent with the predicted secondary structure, which indicates an intervening nonstructured linker region separating the highly structured N- and C-terminal domains. Amino terminal sequencing indicates that the 45 and 55 kDa fragments correspond, respectively, to the membrane-distal and -proximal regions. Plasmin treatment of membrane betaglycan results in the production of equivalent proteolysis-resistant fragments. The 45 and 55 kDa fragments, as well as their recombinant soluble counterparts, Sol Delta10 and Sol Delta11, bind TGF-beta, but nonetheless, compared to intact soluble betaglycan, have a severely diminished ability to block TGF-beta activity. Surface plasmon resonance (SPR) analysis indicates that soluble betaglycan has K(d)'s in the low nanomolar range for the three TGF-beta isoforms, while those for Sol Delta10 and Sol Delta11 are 1-2 orders of magnitude higher. SPR analysis further shows that the K(d)'s of Sol Delta11 are not changed in the presence of Sol Delta10, indicating that the high affinity of soluble betaglycan is a consequence of tethering the domains together. Overall, these results suggest that betaglycan ectodomain exhibits a bilobular structure in which each lobule folds independently and binds TGF-beta through distinct nonoverlapping interfaces and that linker modification may be an approach to improve soluble betaglycan's TGF-beta neutralizing activity.
TGRNet: A Table Graph Reconstruction Network for Table Structure Recognition (2021)

A table arranging data in rows and columns is a very effective data structure, which has been widely used in business and scientific research. Considering large-scale tabular data in online and offline documents, automatic table recognition has attracted increasing attention from the document analysis community. Though human can easily understand the structure of tables, it remains a challenge for machines to understand that, especially due to a variety of different table layouts and styles. Existing methods usually model a table as either the markup sequence or the adjacency matrix between different table cells, failing to address the importance of the logical location of table cells, e.g., a cell is located in the first row and the second column of the table. In this paper, we reformulate the problem of table structure recognition as the table graph reconstruction, and propose an end-to-end trainable table graph reconstruction network (TGRNet) for table structure recognition. Specifically, the proposed method has two main branches, a cell detection branch and a cell logical location branch, to jointly predict the spatial location and the logical location of different cells. Experimental results on three popular table recognition datasets and a new dataset with table graph annotations (TableGraph-350K) demonstrate the effectiveness of the proposed TGRNet for table structure recognition. Code and annotations will be made publicly available.
Therapeutic live vaccines as a potential anticancer strategy (2012)

The design of efficient cancer treatments is one of the major challenges of medical science. Therapeutic vaccines of cancer have been emerged as an attractive approach for their capacity of breaking the immune tolerance and invoking long-term immune response targeting cancer cells without autoimmunity. An efficient antigen delivery system is the key issue of developing an effective cancer vaccine. In this regard, live vaccination strategies including various live bacterial and viral vectors have attracted a great attention. Several bacterial strains such as Salmonella, Listeria monocytogenes and Lactococcus lactis effectively colonize solid tumors and act as antitumor therapeutics. On the other hand, the use of viruses as vaccine vectors such as Vaccinia, Adenovirus, Herpes simplex virus, Paramyxovirus and Retroviruses utilizes mechanisms that evolved in these microbes for entering cells and capturing the cellular machinery to express viral proteins. Viral/bacterial-vectored vaccines induce systemic T-cell responses including polyfunctional cytokine-secreting CD4+ and CD8+ T-cells. However, there is an urgent need for the development of new safe live vaccine vectors that are capable of enhancing antigen presentation and eliciting potent immune responses without the risk of development of disease in humans. Recently, nonpathogenic parasites including Leishmania tarentolae, Toxoplasma gondii and Trypanosoma cruzi have emerged to be a novel candidate for gene delivery and heterologous genes expression. In this review, recent researches on cancer therapy using genetically modified bacteria and virus are summarized. In addition, live parasite-based vectors will be discussed as a novel anticancer therapeutic approach.
A Full-Duplex Receiver Leveraging Multiphase Switched-Capacitor-Delay Based Multi-Domain FIR Filter Cancelers (2020)

Wideband self-interference cancellation (SIC) in full-duplex (FD) radios requires the achievement of large delays to accurately emulate the SI channel. However, compact, power-efficient, low-loss/noise nanosecond-scale delays are extremely challenging to achieve on silicon. Passive LC-based approaches are area intensive, whereas active approaches are power hungry and noisy. In this work, we presented a technique which leverages switched-capacitor circuits with multiphase clocking to obtain large on-chip delays with low area and power consumption. This technique is demonstrated in a FD receiver with time-interleaved switched-capacitor-based delay cells in RF and BB domains. The FD receiver is implemented in a standard 65nm CMOS process and operates from 100MHz - 1GHz with gain tunability of 15-38dB, noise figure of 5.4dB, and power consumption of 31mW. The canceler delay cells have delays ranging from 0.2ns-1.1ns in the RF domain, and 10ns-75ns in the BB domain, while consuming 25.5mW and 6.5mW respectively. These large tunable delays perform FIR-filtering based cancellation, enabling 30-35dB integrated SI cancellation over 20MHz on top of an off-the-shelf ferrite circulator when terminated by a dipole antenna (isolation of 22dB), and can handle TX power of up to +9dBm. Under SIC, the RF and BB cancelers degrade the RX noise figure by 1.1dB and 0.8dB respectively.
Computation of scattering from N spheres using multipole reexpansion (2002)

A computational technique for the solution of problems of wave scattering from multiple spheres is developed. This technique, based on the T-matrix method, uses the theory for the translation and reexpansion of multipole solutions of the Helmholtz equation for fast and exact recursive computation of the matrix elements. The spheres can have prescribed radii, impedances, and locations. Results are validated by comparison with boundary element calculations, and by convergence analyses. The method is much faster than numerical methods based on discretization of space, or of the sphere surfaces. An even faster method is presented for the case when the spheres are aligned coaxially.
Etv2 rescues <i>Flk1</i> mutant embryoid bodies (2013)

Independent mouse knockouts of Etv2 and Flk1 are embryonic lethal and lack hematopoietic and endothelial lineages. We previously reported that Flk1 activates Etv2 in the initiation of hematopoiesis and vasculogenesis. However, Flk1 and its ligand VEGF are expressed throughout development, from E7.0 to adulthood, whereas Etv2 is expressed only transiently during embryogenesis. These observations suggest a complex regulatory interaction between Flk1 and Etv2. To further examine the Flk1 and Etv2 regulatory interaction, we transduced Etv2 and Flk1 mutant ES cells with viral integrants that inducibly overexpress Flk1 or Etv2. We demonstrated that forced expression of Etv2 rescued the hematopoietic and endothelial potential of differentiating Flk1 and Etv2 mutant cells. We further discovered that forced expression of Flk1 can rescue that of the Flk1, but not Etv2 mutant cells. Therefore, we conclude that the requirement for Flk1 can be bypassed by expressing Etv2, supporting the notion that disruption of Etv2 expression is responsible for the early phenotypes of the Etv2 and Flk1 mutant embryos.
Prefrontal Cortex Mediates Extinction of Responding by Two Distinct Neural Mechanisms in Accumbens Shell (2012)

Suppression of ill-timed or competing actions optimizes goal-directed behaviors. Diminished inhibitory control over such actions is a central feature of such disorders as impulsivity, obesity, and drug addiction. The ventromedial prefrontal cortex (vmPFC) is involved in suppression of unreinforced actions. Using reversible inactivation in rats, we demonstrate that vmPFC activity is also required for inhibition of unreinforced actions extinguished during learning of a cued appetitive task and that behavioral disinhibition following vmPFC inactivation depends on dopamine signaling in nucleus accumbens shell (NAcS). Combining electrophysiological recording in NAcS with vmPFC inactivation in rats reveals two neural mechanisms by which vmPFC inhibits unreinforced actions. The first is by suppressing phasic excitations that promote behavioral cue responding. The second is by increasing the basal firing of NAcS neurons that tonically inhibit reward seeking. These results identify the vmPFC and the NAcS as critical elements of the circuits relevant to suppression of inappropriate actions.
Mechanical clot damage from cavitation during sonothrombolysis (2013)

Recent studies have shown that high intensity focused ultrasound (HIFU) accelerates thrombolysis for ischemic stroke. Although the mechanisms are not fully understood, cavitation is thought to play an important role. The goal of this paper is to investigate the potential for cavitation to cause mechanical damage to a blood clot. The amount of damage to the fiber network caused by a single bubble expansion and collapse is estimated by two independent approaches: One based on the stretch of individual fibers and the other based on the energy available to break individual fibers. The two methods yield consistent results. The energy method is extended to the more important scenario of a bubble outside a blood clot that collapses asymmetrically creating an impinging jet. This leads to significantly more damage compared to a bubble embedded within the clot structure. Finally, as an example of how one can apply the theory, a simulation of the propagation of HIFU waves through model calvaria of varying density is explored. The maximum amount of energy available to cause damage to a blood clot increases as the density of the calvaria decreases.
Analysis of Battery Safety and Hazards' Risk Mitigation (2008)

For several years now, there has been a strong drive in the automotive industry to displace the NiMH batteries in Hybrid Electric Vehicles (HEV) with lighter, more durable, more powerful and potentially less expensive Li-Ion batteries. These efforts have been hampered mostly by the concerns over the safety of the Li-Ion batteries. Such concerns have been overblown by merely focusing on abusive testing without paying equal attention to assessing the risk posed by such batteries in the event of a mishap. History shows that the automotive industry has been very successful in managing the risk posed by gasoline, a highly combustible fluid with an energy density 100 times more than the most energy-dense of advance batteries. This paper discusses a methodology developed for the risk assessment of advance batteries. Although the focus here is on the batteries used in hybrid, electric, or plug-in vehicles, the methodology itself, called Hazard Modes & Risk Mitigation Analysis (HMRMA), is quite general and can be used in other applications for batteries as well as for other components & parts that maybe considered hazardous. In addition, the methodology quantifies the risk associated with each hazard and becomes a valuable design tool to develop the most effective way of reducing the risk.
The role of the prefrontal cortex in self-consciousness: the case of auditory hallucinations (1996)

Many patients with schizophrenia report hallucinations in which they hear voices talking to them or about them. Behavioural and physiological studies show that this experience is associated with processes occurring in auditory language systems associated with both the production and the reception of speech. I propose that hallucinations are experienced because patients have difficulty in distinguishing sensations caused by their own actions from those that arise from external influences. This distinction can be made by predicting the sensations that will result from executive commands (forward modelling). If the predicted sensation matches the actual sensation then no outside influences have occurred and perception of change can be 'cancelled'. At the physiological level this mechanism depends upon interactions between the prefrontal areas where the executive commands originate and posterior brain regions concerned with the resultant sensations. Evidence from functional brain imaging confirms that interactions between prefrontal (executive) areas and auditory association areas are abnormal in schizophrenia. However, this account needs to be extended before we can understand why patients experience the voices as emanating, not just from an external source, but from agents who are trying to influence their behaviour. Recent imaging studies suggest that medial prefrontal cortex is engaged when we think about other people, but the precise nature of the interaction of this brain area with other regions remains to be established.
Yield, Quality, and Fruit Distribution in Bollgard/Roundup Ready and Bollgard II/Roundup Ready Flex Cottons (2008)

New transgenic cotton ( Gossypium hirsutum L.) technologies Bollgard II/Roundup Ready Flex (BGII/RRF) provide additional mechanisms for the cotton crop to retain early initiated fruiting structures positioned in the lower canopy. It may be possible, therefore, for early fruit retention to become too high with these new technologies resulting in early cutout and reduced yield. The objective of this investigation was to determine if glyphosate‐induced differences in early season retention occur between BGII/RRF and the older Bollgard/Roundup Ready (BG/RR) technologies and if so, to test if these differences in retention impact crop maturity, yield, or quality under irrigated and nonirrigated conditions. A study was conducted in 2004 and 2005 at two locations in southwestern Georgia to compare the two technologies under dryland vs. irrigation with or without flower removal. The BG/RR matured later than BGII/RRF when glyphosate was applied late at the seventh and 11th leaf stages. The BG/RR compensated for fruit loss by producing heavier remaining bolls. The BGII/RRF maturity was unaffected by the late glyphosate applications and produced a higher percentage of plants having a harvestable boll in the lower canopy than BG/RR. The BGII/RRF cotton had increased boll number and weight at the first sympodial position at lower main stem nodes while BG/RR produced more and heavier bolls on upper main stem nodes. Flower removal did not negatively affect BGII/RRF or BG/RR yields. Few differences in fiber quality were observed. The BGII/RRF retained more early reproductive structures than BG/RR but also cutout earlier. Yield differences between the two technologies may be due to agronomic performance of the variety backgrounds used.
Meet me where i'm gazing (2014)

In this paper we provide empirical evidence that using humanlike gaze cues during human-robot handovers can improve the timing and perceived quality of the handover event. Handovers serve as the foundation of many human-robot tasks. Fluent, legible handover interactions require appropriate nonverbal cues to signal handover intent, location and timing. Inspired by observations of human-human handovers, we implemented gaze behaviors on a PR2 humanoid robot. The robot handed over water bottles to a total of 102 naïve subjects while varying its gaze behaviour: no gaze, gaze designed to elicit shared attention at the handover location, and the shared attention gaze complemented with a turn-taking cue. We compared subject perception of and reaction time to the robot-initiated handovers across the three gaze conditions. Results indicate that subjects reach for the offered object significantly earlier when a robot provides a shared attention gaze cue during a handover. We also observed a statistical trend of subjects preferring handovers with turn-taking gaze cues over the other conditions. Our work demonstrates that gaze can play a key role in improving user experience of human-robot handovers, and help make handovers fast and fluent.