gebhart/patrepeval huggingface dataset:
In vitro protection of umbilical cord blood–derived primitive hematopoietic stem progenitor cell pool by mannose‐specific lectins via antioxidant mechanisms (2010)

The data show that both BL and GL protect the primitive HSPCs in vitro and may also serve as cost-effective HSPC enrichment tools.
Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan (1996)

Germline mutation analysis was performed in 469 VHL families from North America, Europe, and Japan. Germline mutations were identified in 300/469 (63%) of the families tested; 137 distinct intragenic germline mutations were detected. Most of the germline VHL mutations (124/137) occurred in 1-2 families; a few occured in four or more families. The common germline VHL mutations were: delPhe76, Asn78Ser, Arg161Stop, Arg167Gln, Arg167Trp, and Leu178Pro. In this large series, it was possible to compare the effects of identical germline mutations in different populations. Germline VHL mutations produced similar cancer phenotypes in Caucasian and Japanese VHL families. Germline VHL mutations were identified that produced three distinct cancer phenotypes: (1) renal carcinoma without pheochromocytoma, (2) renal carcinoma with pheochromocytoma, and (3) pheochromocytoma alone. The catalog of VHL germline mutations with phenotype information should be useful for diagnostic and prognostic studies of VHL and for studies of genotype-phenotype correlations in VHL.
Pilot contamination precoding for interference reduction in large scale antenna systems (2013)

A large scale antenna system (LSAS) entails a large number of base station (BS) antennas serving a much smaller number of terminals. LSAS demonstrates large gain in spectral-efficiency and energy-efficiency compared with conventional MIMO schemes. In the regime of infinite number of BS antennas, the performance of LSAS can be improved unboundedly by using a multi-cell cooperation method called pilot contamination precoding (PCP). As the number of BS antennas grows PCP completely cancels inter-cell interference resulted from unavoidable use of nonorthogonal pilot sequences in neighboring cells. In this paper, we consider downlink PCP design in the finite antenna regime, where besides pilot contamination, three other types of interference become prominent. We formulate the PCP design as maximizing the minimum signal to interference-plus-noise ratio (SINR) subject to network sum power constraint. We propose optimal and simple suboptimal algorithms for finding PCP matrices. We show that in a practical scenario, say with M = 100 antennas, these approaches give very significant improvement over conventional LSASs.
Measurement of the intensity and phase of a single ultrashort pulse: A simple and general technique (1993)

We have developed a simple, intuitive, self‐contained, and general technique for measuring the intensity and phase of a single arbitrary ultrashort pulse. We use a novel arrangement and reduce the mathematics of the problem to the two‐dimensional phase‐retrieval problem—a well‐known, solved problem in image science.
"Warm Bodies": A Post-Processing Technique for Animating Dynamic Blood Flow on Photos and Avatars (2021)

What breathes life into an embodied agent or avatar? While body motions such as facial expressions, speech and gestures have been well studied, relatively little attention has been applied to subtle changes due to underlying physiology. We argue that subtle pulse signals are important for creating more lifelike and less disconcerting avatars. We propose a method for animating blood flow patterns, based on a data-driven physiological model that can be used to directly augment the appearance of synthetic avatars and photo-realistic faces. While the changes are difficult for participants to "see", they significantly more frequently select faces with blood flow as more anthropomorphic and animated than faces without blood flow. Furthermore, by manipulating the frequency of the heart rate in the underlying signal we can change the perceived arousal of the character.
Consistency and locking for distributing updates to web servers using a file system (2000)

Distributed file systems are often used to replicate a Web site's content among its many servers. However, for content that needs to be dynamically updated and distributed to many servers, file system locking protocols exhibit high latency and heavy network usage. Poor performance arises because the Web-serving workload differs from the assumed workload. To address the shortcomings of file systems, we introduce the publish consistency model well suited to the Web-serving workload and implement it in the producer-consumer locking protocol. A comparison of this protocol against other file system protocols by simulation shows that producer-consumer locking removes almost all latency due to protocol overhead and significantly reduces network load.
Dynamic stochastic optimal power flow control for intelligent coordination of grid-connected energy systems (2012)

High penetration of intermittent renewable energy demands major upgrades to the existing power grid transmission infrastructure. Increasing transmission capacities and interconnections creates larger balancing areas. With a larger balancing area, more grid-connected energy systems can be coordinated to achieve one or multiple control objectives (for example, balancing intermittent renewable energy), but how to achieve such an optimal coordination has not yet been fully answered. The existing power system operation method is based on steady-state optimization that may break down when fast variation is present in the system. To provide a coordinating control solution to multiple grid-connected energy systems, an intelligent real-time power flow control method, namely the dynamic stochastic optimal power flow (DSOPF) control, is presented in this paper. The DSOPF control algorithm is based on the Adaptive Critic Designs (ACDs), which provide methods to design optimal neurocontrollers without the need of system analytical models. Studies on a 12-bus and a 70-bus test power system are presented to demonstrate the DSOPF controller.
Chalcogenide fiber based mid-IR sources and applications (2015)

In the visible and near-IR, silica fiber high power lasers, amplifiers, fiber combiners, couplers, fiber optic switches and attenuators have demonstrated impressive performance and have become critical technologies for many applications such as telecommunications, spectroscopy, sensing, laser machining, and directed energy. As mid-IR and long-wave IR applications become more prolific, the need for analogous devices in the IR becomes important. Chalcogenide fiber shows great promise for meeting the source and device needs for applications in the IR. Chalcogenide fiber has a broad transmission range out to 12 μm, depending upon composition, and is ideal for transmission of light in these wavelength ranges. In addition, chalcogenide fibers can be doped with rare earth ions or the high nonlinearity of chalcogenide glasses can be exploited to fabricate sources in the mid and long-wave-IR. In work to date, we have demonstrated an all-fiber broadband supercontinuum source in the mid-IR from 1.9 to 4.8 μm and have scaled up the power to >500 mW in this wavelength range [1]. We have also demonstrated a microchip laser pumped mid-IR supercontinuum source from 3.65 to 4.9 μm [2], IR fiber Raman amplification [3], and broad band mid-IR rare earth doped fiber sources [4]. Passive optical devices that we have demonstrated include chalcogenide fiber based optical attenuators [5], registered coherent imaging bundles [6] and multimode fiber combiners for power and wavelength combining of quantum cascade lasers [7]. In addition, we have developed methods to fabricate high power anti-reflection surface structures on chalcogenide fibers [8], splicing methods for chalcogenide fibers, and cabling and termination methods for fibers to allow the fiber sources and devices to be packaged for applications. Environmental testing and power testing has been performed on chalcogenide fiber and devices to determine the operational limits of these technologies. In this paper, we will review our prior and recent work on chalcogenide based mid-IR sources and devices and the packaging, characterization and applications of these sources and devices.
<title>Approach to detect the intended output medium from the image data</title> (1999)

One of the image quality problems with printing images from the WEB is that the color information associated with those images is normally incomplete, or even incorrect. In order to generate a good printout of an arbitrary image from the WEB, certain assumptions have to be made. The major variant in image quality can be found in terms of the intended (gamma) the image was designed for. The example is a WEBsite, hosting an image collection. The site might allow you to browse and print images. However, browsing is normally done on a monitor with a (gamma) of roughly 2 and printing is done on a xerographic or ink-jet printer with a (gamma) of 1. The display and print images will therefore differ quite drastically, unless the (gamma) is corrected. Unfortunately, it is not known which (gamma) setting was used by the WEBsite, and therefore a fixed conversion (e.g.: always assuming the data is intended for monitor (gamma) ) is often faulty. This talk describes a way around this problem by trying to automatically identify the correct (gamma) based on the image data.
Role of Vasoactive Intestinal Peptide in the Control of Prolactin-Induced Turkey Incubation Behavior. I. Acute Infusion of Vasoactive Intestinal Peptide1 (1994)

Vasoactive intestinal peptide (VIP) stimulates prolactin (PRL) secretion. Ovine PRL induces incubation behavior in avian species. This study was designed to determine whether VIP can elevate plasma PRL for up to 3 h. Saline or porcine VIP (pVIP; 30, 60, or 150 ng/min) was infused into the median eminence of laying turkeys for 1 h. The 60- and 150-ng doses of pVIP increased plasma PRL (p < 0.01), whereas the 30-ng dose was insignificant. Pituitary PRL content decreased in pVIP-treated turkeys. Two-hour infusion of 60 or 150 ng chicken VIP (cVIP)/min produced similar elevations of plasma PRL (p < 0.001), which declined within 80 min. Both treatments induced insignificant increases in pituitary PRL mRNA. Saline or cVIP (30, 60, or 60 [pulsed] ng/min) was infused into the median eminence for 3 h. Sixty ng cVIP/min induced the largest PRL release (p < 0.05). The pulsatile and low-cVIP treatments resulted in release of a significant amount of PRL in comparison to the saline treatment (p < 0.01). All cVIP treatments resulted in decreased pituitary PRL content (p < 0.05). The 60-ng dose increased PRL mRNA (p < 0.1). This study shows that 60 ng VIP/min causes the maximum PRL release in laying turkeys. However, pituitary PRL content is depleted and PRL synthesis cannot maintain PRL secretion at high levels.
5-Substituted-2,4-imidazolidinediones (1992)

Two isomeric forms of 5-substituted-2,4-imidazolidinediones have been found to have herbicidal properties. Novel, efficient and unambiguous synthetic routes to these isomeric materials are described. Their structure activity relationships and crop selectivity patterns are discussed.
New Synergetic Control of a 20kW Isolated VIENNA Rectifier Front-End EV Battery Charger (2019)

EV chargers with output power levels in the range of tens of kW are typically employing a front-end three-phase boost-type PFC rectifier stage for sinusoidal input current and DC-link voltage control, and a series-connected isolated DC/DC converter controlling the actual output/charging current or voltage. This paper explores a new synergetic control of both converter stages, which utilizes the DC/DC converter also for varying the DC-link voltage with six times the mains frequency, such that the currents of two mains phases are shaped sinusoidally. Accordingly, two bridge legs of the rectifier stage can remain clamped in 60°-wide intervals of the mains cycle and the pulse width modulation (PWM) can be restricted to the phase carrying the lowest current, i.e., only one of the three bridge legs is operated with PWM, designated as 1/3-PWM. Furthermore, the DC-link voltage that is switched by the operating rectifier phase is kept to the minimum and the system features high efficiency and low EMI, but still maintains boost capability, i.e., the option of conventional PWM of all three rectifier bridge legs (thus denominated as 3/3-PWM), which is advantageous in case a wide input or output voltage range needs to be covered. The new control concept is derived starting from a conventional approach with constant DC-link voltage, and is verified by simulations for a three-level Vienna Rectifier front-end and two cascaded DC/DC modules supplied from the halves of the symmetrically partitioned DC-link voltage. First, the operating behavior of the system utilizing the proposed control is described analytically. Next, the performance improvement achievable with the proposed control scheme is comparatively evaluated for a 20kW system designed for operation in a wide mains voltage range (260-530V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> line-to-line) and an extremely wide DC output / battery voltage range (150-750V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dc</sub> ), according to EV charging equipment supplier requirements of the State Grid Corp. of China. Finally, simulation results are presented which validate the operating principle of the proposed modulation and control scheme.
High-Throughput Selective Capture of Single Circulating Tumor Cells by Dielectrophoresis at a Wireless Electrode Array (2017)

We demonstrate continuous high-throughput selective capture of circulating tumor cells by dielectrophoresis at arrays of wireless electrodes (bipolar electrodes, BPEs). The use of BPEs removes the requirement of ohmic contact to individual array elements, thus enabling otherwise unattainable device formats. Capacitive charging of the electrical double layer at opposing ends of each BPE allows an AC electric field to be transmitted across the entire device. Here, two such designs are described and evaluated. In the first design, BPEs interconnect parallel microchannels. Pockets extruding from either side of the microchannels volumetrically control the number of cells captured at each BPE tip and enhance trapping. High-fidelity single-cell capture was achieved when the pocket dimensions were matched to those of the cells. A second, open design allows many non-targeted cells to pass through. These devices enable high-throughput capture of rare cells and single-cell analysis.
Metabotropic glutamate receptor agonists reduce glutamate release from cultured astrocytes (1999)

Astrocytes are thought to control extracellular glutamate concentrations ([Glu]o) in the brain, thereby protecting neurons from excitotoxic injury. We investigated the effects of metabotropic glutamate receptor (mGluR) agonists on glutamate transport and [Glu]o in primary hippocampal astrocytic cultures. Acute or chronic exposure of astrocytes to the mGluR agonist trans-1-aminocyclopentane-1,3-dicarboxylic acid (trans-ACPD) or its active isomer 1S,3R-ACPD reduced [Glu]o in a time- and dose-dependent manner (44.5 ± 3.6% reductions of [Glu]o in astrocytes from P0–P10 rats and 65.9 ± 4.1 % from rats P20 by 100 μM 1S,3R-ACPD, EC50 ∼ 5 μM). 1S,3R-ACPD effects developed slowly (median effective at ∼60 min) and persisted for several hours after agonist removal. ACPD-pretreated astrocytes established lower steady-state [Glu]o levels. ACPD effects persisted in the presence of the glutamate uptake inhibitors D,L-threo-β-hydroxyaspartate (THA) and L-trans-pyrrolidine-2,4-dicarboxylate (PDC) but were impaired by disruption of the transmembrane Na+, K+, or H+ gradients. In addition, 1S,3R-ACPD had no effects on intracellular glutamate content and did not directly block glutamate transport. Furthermore, ACPD effects could be mimicked by glutamate per se and several other compounds presumed to be mGluR agonists, although (S)-3,5-dihydroxyphenylglycine (DHPG), (2S,2R,3R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV), and L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) were without effect. These data suggest that glutamate and certain mGluR agonists may regulate [Glu]o by modulating the transmembrane equilibrium of glutamate transport, especially by attenuating glutamate release. GLIA 25:270–281, 1999. © 1999 Wiley-Liss, Inc.
High-efficiency GaP pure green light-emitting diodes of 555 nm fabricated by new liquid phase epitaxy method (1983)

A new liquid phase epitaxy (LPE) method, which can control impurity concentration by volatilization of impurities from the growth solution under reduced pressure, has been developed. Using this LPE method, high-efficiency GaP pure green light-emitting diodes, of which the peak wavelength is 555 nm, has been obtained. The average efficiency for a epoxy-encapsulated diode is 0.1% and the maximum efficiency is 0.14% at 16 A/cm2.
Automatic disc loading and unloading system for recording-disc playback apparatus (1985)

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High-throughput widefield fluorescence imaging of 3D samples using deep learning for 2D projection image restoration (2022)

Fluorescence microscopy is a core method for visualizing and quantifying the spatial and temporal dynamics of complex biological processes. While many fluorescent microscopy techniques exist, due to its cost-effectiveness and accessibility, widefield fluorescent imaging remains one of the most widely used. To accomplish imaging of 3D samples, conventional widefield fluorescence imaging entails acquiring a sequence of 2D images spaced along the z-dimension, typically called a z-stack. Oftentimes, the first step in an analysis pipeline is to project that 3D volume into a single 2D image because 3D image data can be cumbersome to manage and challenging to analyze and interpret. Furthermore, z-stack acquisition is often time-consuming, which consequently may induce photodamage to the biological sample; these are major barriers for workflows that require high-throughput, such as drug screening. As an alternative to z-stacks, axial sweep acquisition schemes have been proposed to circumvent these drawbacks and offer potential of 100-fold faster image acquisition for 3D-samples compared to z-stack acquisition. Unfortunately, these acquisition techniques generate low-quality 2D z-projected images that require restoration with unwieldy, computationally heavy algorithms before the images can be interrogated. We propose a novel workflow to combine axial z-sweep acquisition with deep learning-based image restoration, ultimately enabling high-throughput and high-quality imaging of complex 3D-samples using 2D projection images. To demonstrate the capabilities of our proposed workflow, we apply it to live-cell imaging of large 3D tumor spheroid cultures and find we can produce high-fidelity images appropriate for quantitative analysis. Therefore, we conclude that combining axial z-sweep image acquisition with deep learning-based image restoration enables high-throughput and high-quality fluorescence imaging of complex 3D biological samples.
Cleaved Amplified Polymorphic Sequence and Amplified Fragment Length Polymorphism Markers Linked to the Fertility Restorer Gene in Chili Pepper (Capsicum annuum L.) (2006)

Cytoplasmic male sterility (CMS) in plants, which is due to failure to produce functional pollen, is a maternally inherited trait. Specific nuclear genes that sup-press CMS, termed fertility restorer (Rf) genes, have been identified in several plants. In this study, Rf-linked molecular markers in pepper (Capsicum annuum L.) were detected by bulked segregant analysis of eight amplified fragment length polymorphisms (AFLPs). Only AFRF8 was successfully converted to a cleaved amplified polymorphic sequence (CAPS) marker. This was named AFRF8CAPS and genotype determination using it agreed with that obtained with the original AFRF8. A linkage map with a total size of 54.1 cM was constructed with AFRF8CAPS and the seven AFLP markers using the Kosambi function. The AFRF8CAPS marker was shown to be closest to Rf with a genetic distance of 1.8 cM. These markers will be useful for fast and reliable detection of restorer lines during F(1) hybrid seed production and breeding programs in pepper.
A Two‐Dimensional Liquid Mass Mapping Technique for Biomarker Discovery (2008)

This chapter contains sections titled: Introduction Methods for Separating and Identifying Proteins Applications Summary and Conclusions Acknowledgments References
Replica shuffled iterative decoding (2005)

Replica shuffled versions of iterative decoders of turbo codes, low-density parity-check codes and turbo product codes are presented. The proposed schemes converge faster than standard and previously proposed "shuffled" approaches. Simulations show that the new schedules offer good performance versus complexity/latency trade-offs.
Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT1A receptor (2005)

A new generation of antidepressant agents could be represented by compounds with mixed activity as serotonin transporter (SERT) inhibitors and 5-HT(1A) receptor antagonists. We report here on the synthesis and evaluation of SERT and 5-HT(1A) receptor affinity of long-chain arylpiperazines obtained either by modifying 6-nitroquipazine into a long-chain arylpiperazine or by inserting a modified 6-nitroquipazine moiety or other structures endowed with SERT affinity into a long-chain arylpiperazine with 5-HT(1A) affinity. Among the compounds studied, 2-[4-(2-methoxyphenyl)piperazin-1-yl]-N-(6-nitro-2-quinolyl)ethylamine (21) and 1-(5-bromo-1,2,3,4-tetrahydronaphthalen-1-yl)-3-[4-(2-methoxyphenyl)-piperazin-1-yl]-1-propanone (24) showed good affinity values for SERT and 5-HT(1A) receptors (SERT: K(i) (inhibition constant)=71.8 and 62.8 nM; 5-HT(1A)K(i)=14.2 and 0.82 nM, respectively).
Boosting the Catalytic Performance of Metal–Organic Frameworks for Steroid Transformations by Confinement within a Mesoporous Scaffold (2017)

Solid-state crystallization achieves selective confinement of metal-organic framework (MOF) nanocrystals within mesoporous materials, thereby rendering active sites more accessible compared to the bulk-MOF and enhancing the chemical and mechanical stability of MOF nanocrystals. (Zr)UiO-66(NH<sub>2</sub> )/SiO<sub>2</sub> hybrid materials were tested as efficient and reusable heterogeneous catalysts for the synthesis of steroid derivatives, outperforming the bulk (Zr)UiO-66(NH<sub>2</sub> ) MOF. A clear correlation between the catalytic activity of the dispersed Zr sites present in the confined MOF, and the loading of the mesoporous SiO<sub>2</sub> , is demonstrated for steroid transformations.
Model-Predictive Control to realize the Switching-Cycle Capacitor Voltage Control for the modular multilevel converters (2015)

This paper presents a Model-Predictive Control (MPC) scheme that can be used in realizing the Switching-Cycle Capacitor Voltage Control (SCCVC) for the power cells of the Modular Multilevel Converters (MMC). The capacitor voltage will follow the reference in one switching cycle by controlling the average currents that flow through the capacitors to zero. The Model-Predictive Control can diminish negative impact brought by the time delay in the digital controller, in which the switching-cycle control cannot be achieved conventionally. The SCCVC with MPC thoroughly decouples the capacitor voltage ripple magnitude apart from the line frequency, which not only provides a significant reduction of the cell capacitance and arm inductance, but also enable the MMC to deliver very low frequency line current without derating.