gebhart/patrepeval huggingface dataset:
Thermal neutron imaging tests using Ce doped LiCaAlF<inf>6</inf> and sealed <sup>252</sup>Cf source (2010)

Thermal neutron imaging with Ce doped <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> LiCaAlF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> , which is a novel thermal neutron scintillator, was demonstrated. Ce doped <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> LiCaAlF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> single crystal was grown by Czochralski technique and grown crystal was cut and polished to a plate shape. Setup of the thermal neutron imaging consisted of the plate shaped Ce doped <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> LiCaAlF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> , a position sensitive photomultiplier tube, alphabet-shaped Cd-masks and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">252</sup> Cf in the polyethylene container. As a result, clear neutron image was successfully observed.
Autonomous Flight Control of Hobby-Class Small Unmanned Helicopter (Modeling Based on Experimental Identification and Autonomous Flight Control Experiments) (2004)

We developed a small autonomous hobby-class unmanned helicopter that weighs about 9 kg, focusing on attitude and velocity models and controller design. Singe Input Single Output (SISO) transfer function models are derived from brief kinematical analysis and system identification for each of the helicopter dynamics of pitch, roll, yaw, and three direction velocities. We designed six separate controllers based on derived models using LQG and LQI control theory. The models and control structure are verified by experimental results. Accurate position control, namely, hover control and trajectory-following control, is achieved by a simple control algorithm using a designed attitude and velocity control structure. Robustness of the controller against wind was confirmed in a windy-day experiment. To verify robustness against the perturbation of physical helicopter parameters, the controller is applied to a larger helicopter.
Expanding automatic external defibrillators to include automated detection of cardiac, respiratory, and cardiorespiratory arrest (2002)

The new Guidelines of the American Heart Association state that lay rescuers can no longer rely on the manual pulse check to confirm cardiac arrest in an unresponsive patient. We were therefore prompted to develop a method for automated determination of the presence or absence of cardiac contraction and breathing. The technique was designed to be incorporated into conventional automated external defibrillators and to work in conjunction with the information derived from rhythm analyses by the automated defibrillator. Using conventional electrocardiographic sensing and defibrillation electrodes, the transthoracic impedance was measured by passing a constant amplitude alternating current of 5 mA through the thorax at a frequency of 35 kHz. In five anesthetized male domestic swine, we observed pulses that were coincident with cardiac contraction documented by esophageal echocardiography. In addition, we observed larger signals of lower frequency that were time related to ventilation and documented by capnography. Both signals disappeared after inducing ventricular fibrillation. The impedance measurement identified respiratory arrest in anesthetized animals and primary cardiac arrest after ventricular fibrillation was induced. The cardiac arrest detector is therefore likely to augment the current information provided by automated defibrillators and to allow for more precise verbal prompting of lay rescuers.
Development of a Methodology to Separate Thermal from Oil Aging of a Catalyst Using a Gasoline-Fueled Burner System (2003)

<div class="htmlview paragraph">Typically, an engine/dynamometer thermal aging cycle contains combinations of elevated catalyst inlet temperatures, chemical reaction-induced thermal excursions (simulating misfire events), and average air/fuel ratio's (AFR's) to create a condition that accelerates the aging of the test part. In theory, thermal aging is predominantly a function of the time at an exposure temperature. Therefore, if a burner system can be used to simulate the exhaust AFR and catalyst inlet and bed temperature profile generated by an engine running an accelerated aging cycle, then a catalyst should thermally age the same when exposed to either exhaust stream.</div> <div class="htmlview paragraph">This paper describes the results of a study that examined the aging difference between six like catalysts aged using the Rapid Aging Test (RAT) cycle (an accelerated thermal aging cycle). Three catalysts were aged using a gasoline-fueled engine aging stand; the other three were aged using a computer controlled burner system. Both systems were programmed to run aging cycles that provided the same inlet temperature and AFR profiles, and space velocity conditions. Each catalyst was evaluated using a vehicle over the FTP emissions test cycle and an AFR sweep test suing an engine test stand before and after aging. Finally, the catalysts were cored and analyzed to provide a composition and surface area comparison.</div>
Abstract 4573: STINGVAX - A novel tumor vaccine with cyclic dinucleotides - can induce potent anti-tumor responses <i>in vivo</i>. (2013)

Abstract Cyclic dinucleotides (CDN) are ubiquitous bacterial intracellular messengers, and they have recently been shown to also function as a pathogen associated molecular pattern (PAMP) molecules that are sensed by eukaryotic host Stimulator of Interferon Genes (STING) that can activate the TBK-1/IRF-3 signaling pathway to induce type I interferon and other co-regulated genes. CDN was found to induce STING dependent augmentation of T-cell priming in multiple vaccination models, potentially by activating dendritic cells. We formulated CDN with a GM-CSF secreting tumor cell vaccine (STINGVAX) to mobilize and as well as activate dendritic cells both in vitro and in vivo. STINGVAX was tested in a stringent B16 melanoma treatment model, and we demonstrated significant reduction of tumor growth rate in vivo. STINGVAX's anti-tumor response was correlated with increased tumor infiltrating CD8 T-cells as well as increased number of p15E tumor-specific cytotoxic T-cells. STINGVAX's in vivo anti-tumor response was T-cell dependent as well as STING dependent. When we combined STINGVAX with multiple TLR 4/7/8 agonists signaling through the MyD88/TRIF pathway that is distinct from CDN/STING/TBK-1 signaling treatment of palpable B16 tumor resulted in regression of 30-60% of these non-immunogenic tumors. When the STINGVAX treated tumor microenvironment was examined, both IFNγ+CD8+ and PD-L1 was upregulated, potentially demonstrating an adaptive immune resistance mechanism which would render STINGVAX an excellent candidate to be combined with anti-PD-1 blockade. Cumulatively, STINGVAX is a novel tumor vaccine with a high potential for translation in clinical oncology. Citation Format: Thomas W. Dubensky, Meredith L. Leong, David B. Kanne, Edward E. Lemmens, Ken Metchette, Weiqun Liu, Marcella Fasso, Juan Fu, Joshua J. Woodward, Drew Pardoll, Daniel A. Portnoy, Young J. Kim. STINGVAX - A novel tumor vaccine with cyclic dinucleotides - can induce potent anti-tumor responses in vivo. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4573. doi:10.1158/1538-7445.AM2013-4573
Performance Evaluation of a Novel Direct Table Lookup Method and Architecture with Application to 16-bit Integer Functions (2006)

We describe several integer function properties which in combination allow direct lookup tables to be reduced in size and structure to simpler lookup trees. Our principal result is a novel table lookup method based on a mapping of a lookup tree to a row-by-column ROM with pre and post processing logic substantially reducing the table size. Our lookup architecture allows common 16-bit integer functions such as multiplicative inverse, square, and the discrete log to be realized with table size of order 2-8 Kbytes, in comparison to the 128 Kbyte size of an arbitrary 16-bits-in 16-bits-out function table. The lookup methodology is illustrated with specific development of the 16-bit integer discrete-log function. Implementation for both unnormalized and normalized indices are synthesized into standard cell netlists and performance and area results are given that demonstrate their effectiveness.
Serial interfacing for embedded-memory testing (1990)

A serial interfacing scheme in which several embedded memories share the built-in, self-test circuit is presented. For external testing, this approach requires only two serial pins for access to the data path. There is considerable savings in routing area, and fewer external pins are needed to test random-access memories with wide words, such as those in application-specific integrated circuits for telecommunications. Even though the method uses serial access to the memory, a test pattern is applied every clock cycle because the memory itself shifts the test data. The method has been adapted to four common algorithms. In implementations of built-in self-test circuitry on several product chips, the area overhead was found to be acceptable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Impact of a human CMP-sialic acid transporter on recombinant glycoprotein sialylation in glycoengineered insect cells (2012)

Insect cells are widely used for recombinant glycoprotein production, but they cannot provide the glycosylation patterns required for some biotechnological applications. This problem has been addressed by genetically engineering insect cells to express mammalian genes encoding various glycoprotein glycan processing functions. However, for various reasons, the impact of a mammalian cytosine-5'-monophospho (CMP)-sialic acid transporter has not yet been examined. Thus, we transformed Spodoptera frugiperda (Sf9) cells with six mammalian genes to generate a new cell line, SfSWT-4, that can produce sialylated glycoproteins when cultured with the sialic acid precursor, N-acetylmannosamine. We then super-transformed SfSWT-4 with a human CMP-sialic acid transporter (hCSAT) gene to isolate a daughter cell line, SfSWT-6, which expressed the hCSAT gene in addition to the other mammalian glycogenes. SfSWT-6 cells had higher levels of cell surface sialylation and also supported higher levels of recombinant glycoprotein sialylation, particularly when cultured with low concentrations of N-acetylmannosamine. Thus, hCSAT expression has an impact on glycoprotein sialylation, can reduce the cost of recombinant glycoprotein production and therefore should be included in ongoing efforts to glycoengineer the baculovirus-insect cell system. The results of this study also contributed new insights into the endogenous mechanism and potential mechanisms of CMP-sialic acid accumulation in the Golgi apparatus of lepidopteran insect cells.
Compact adaptive optics line scanning ophthalmoscope (2009)

We have developed a compact retinal imager that integrates adaptive optics (AO) into a line scanning ophthalmoscope (LSO). The bench-top AO-LSO instrument significantly reduces the size, complexity, and cost of research AO scanning laser ophthalmoscopes (AOSLOs), for the purpose of moving adaptive optics imaging more rapidly into routine clinical use. The AO-LSO produces high resolution retinal images with only one moving part and a significantly reduced instrument footprint and number of optical components. The AO-LSO has a moderate field of view (5.5 deg), which allows montages of the macula or other targets to be obtained more quickly and efficiently. In a preliminary human subjects investigation, photoreceptors could be resolved and counted within approximately 0.5 mm of the fovea. Photoreceptor counts matched closely to previously reported histology. The capillaries surrounding the foveal avascular zone could be resolved, as well as cells flowing within them. Individual nerve fiber bundles could be resolved, especially near the optic nerve head, as well as other structures such as the lamina cribrosa. In addition to instrument design, fabrication, and testing, software algorithms were developed for automated image registration and cone counting.
Sphingolipid targets in cancer therapy (2006)

Considerable progress has been made recently in our understanding of the role of ceramide in the induction of apoptotic cell death. Ceramide is produced by cancer cells in response to exposure to radiation and most chemotherapeutics and is an intracellular second messenger that activates enzymes, leading to apoptosis. Because of its central role in apoptosis, pharmacologic manipulation of intracellular ceramide levels should result in attenuation or enhancement of drug resistance. This may be achieved through direct application of sphingolipids or by the inhibition/activation of the enzymes that either produce or use ceramide. In addition, attention should be given to the subcellular location of ceramide generation, because this has been shown to affect the biological activity of sphingolipids. This review summarizes the sphingolipid biosynthetic pathway, as it relates to the identification of important targets for drug discovery, and the development of novel agents capable of enhancing chemotherapy.
Synthesis of antisense oligonucleotides (1999)

It is demonstrated that mixed-sequence phosphorothioate oligodeoxyribonucleotides can be synthesized on scales up to 80 mmol without using chlorinated solvents like dichloromethane, while preserving both high yield and purity of the product. A solution of dichloroacetic acid in toluene cleanly and efficiently removes 4,4′-dimethoxytrityl groups from the 5′-terminus of the growing oligonucleotide chain during synthesis on solid support. Ammonium hydroxide treatment at room temperature at atmospheric pressure furnishes deprotected oligonucleotides reducing the risk that pressurized reaction glass vessels pose. To ensure facile separation of polymer beads (Primer HL 30) and oligonucleotide solution, minimum agitation of the reaction mixture is applied.
Clinical evaluation of a temperature-sensitive bovine viral diarrhea vaccine strain (1984)

A naturally occurring strain of bovine viral diarrhea (BVD) virus was chemically treated to produce a genetically stable, temperature-sensitive mutant, designated RIT 4350. The RIT 4350 strain had a restrictive growth temperature of 39.5 C, so that systemic replication or fetal infection was not detected after parenteral administration in cattle. The RIT 4350 strain was tested as a cell culture-adapted vaccine in healthy heifers, immunodepressed calves, and pregnant cows. In a pathogenicity test in 5 healthy heifers, vaccination with 10 times the field dose resulted in seroconversion, but produced no clinical signs of disease or leukopenia. In a pathogenicity test in immunodepressed calves, 7 test animals were treated with dexamethasone and inoculated with 10 times the field dose. The calves developed mild enteric signs, but virus isolation attempts were negative. Following vaccination, the immunodepressed vaccinated calves were challenge exposed with the Osloss strain of BVD virus; all these vaccinated calves remained healthy. Two of 68 postchallenge serum samples from vaccinated calves were positive for BVD virus, compared with 9 of 20 samples from control calves. In another pathogenicity test, 7 pregnant cows vaccinated with 4 times the field dose seroconverted, remained clinically healthy, and delivered healthy calves.
Diffusion-Reaction Model of ALD in Nanostructured Substrates: Analytic Approximations to Dose Times as a Function of the Surface Reaction Probability (2011)

We have developed a transport model for Atomic Layer Deposition (ALD) in nanostructured substrates. The model comprises a non-linear advection-diffusion-reaction equation coupled to a surface kinetic equation that incorporates the self-limiting nature of ALD. In their nondimensional forms, these equations show that coverage dynamics in ALD depend only on two parameters: the Damkoeler number and the precursor excess number. These parameters depend on the surface chemistry and experimental conditions and can be readily calculated for a wide range of substrate geometries including trenches and vias, anodized alumina, and powders.
Applications of Hilbert–Huang transform to non‐stationary financial time series analysis (2003)

Abstract A new method, the Hilbert–Huang Transform (HHT), developed initially for natural and engineering sciences has now been applied to financial data. The HHT method is specially developed for analysing non‐linear and non‐stationary data. The method consists of two parts: (1) the empirical mode decomposition (EMD), and (2) the Hilbert spectral analysis. The key part of the method is the first step, the EMD, with which any complicated data set can be decomposed into a finite and often small number of intrinsic mode functions (IMF). An IMF is defined here as any function having the same number of zero‐crossing and extrema, and also having symmetric envelopes defined by the local maxima, and minima respectively. The IMF also thus admits well‐behaved Hilbert transforms. This decomposition method is adaptive, and, therefore, highly efficient. Since the decomposition is based on the local characteristic time scale of the data, it is applicable to non‐linear and non‐stationary processes. With the Hilbert transform, the IMF yield instantaneous frequencies as functions of time that give sharp identifications of imbedded structures. The final presentation of the results is an energy–frequency–time distribution, which we designate as the Hilbert Spectrum. Comparisons with Wavelet and Fourier analyses show the new method offers much better temporal and frequency resolutions. The EMD is also useful as a filter to extract variability of different scales. In the present application, HHT has been used to examine the changeability of the market, as a measure of volatility of the market. Published in 2003 by John Wiley & Sons, Ltd.
Synthesis of Novel Ethoxylated Quaternary Ammonium Gemini Surfactants for Enhanced Oil Recovery Application (2019)

Two aspects are always considered in the design and development of new surfactants for oilfield application. One of them is that surfactant must be sufficiently stable at reservoir temperature and the other is the solubility of the surfactant in the injection water (usually seawater) and the formation brine. Most industrially applied surfactants undergo hydrolysis at elevated temperature and the presence of reservoir ions causes surfactant precipitation. In relevance to this, a novel series of quaternary ammonium gemini surfactants with different length of spacer group (C8, C10, and C12) was synthesized and characterized using FT-IR, 13C NMR, 1H NMR, and MALDI-TOF MS. The gemini surfactants were prepared by solvent-free amidation of glycolic acid ethoxylate lauryl ether with 3-(dimethylamino)-1-propylamine followed by reaction with dibromoalkane to obtain quaternary ammonium gemini surfactants. The gemini surfactants were examined by means of surface properties and thermal stabilities. The synthesized gemini surfactants showed excellent solubility in the formation brine, seawater, and deionized water without any precipitation for up to three months at 90 °C. Thermal gravimetric data revealed that all the gemini surfactants were decomposed above 227 °C, which is higher than the oilfield temperature (≥90 °C). The decrease in critical micelle concentration (CMC) and surface tension at CMC (γcmc) was detected by enhancing spacer length in the order C8 ˃ C10 ˃ C12 which suggested that the larger the spacer, the better the surface properties. Moreover, a further decrease in CMC and γcmc was noticed by enhancing temperature (30 °C ˃ 60 °C) and salinity (deionized water ˃ seawater). The current study provides a comprehensive investigation of quaternary ammonium gemini surfactants that can be further extended potentially to use as a suitable material for oilfield application.
Bathymetric influence on tsunami spatial/temporal patterns in HF radar currents (2012)

Observation of tsunamis with HF radar is possible because of the unique nature of the current patterns accompanying their shallow-water height profile. As these waves approach the coast, their velocity signature strengthens as the cube of the height as depth decreases. Thus the bathymetry near the radar site is the most important factor in determining the detection distance and warning time possible. We analyze these relations for both the temporal and spatial signatures, before and after the arrival of the first wave. Understanding this behavior at each HF radar location is critical in determining the effectiveness of tsunami observation and warning software, and guides the development of required pattern recognition algorithms.
New Bi-Based Garnet Films for Magnetic-Bubble Devices with Magneto-Optic Applications (1974)

LPE films of BixTm3−xGayFe5−yO12 have been grown strain‐free on (111) Gd3Ga5O12 substrates. Films with x ≃ 0.6, 0.8<y<1.2 have relatively stable temperature characteristics, adequate mobility and are compatible with densities of 106–107 bits per square inch. The Faraday rotation is ten times higher than in the conventional bubble garnets, making these Bi‐based films suitable for bubble devices with magneto‐optic applications.
Stabilization of the Optical Tracer Agent Indocyanine Green Using Noncovalent Interactions (2000)

Indocyanine green is a medically useful dye that absorbs and fluoresces in the near infrared and has been sporadically employed clinically as an optical tracer agent for liver function evaluation and cardiac output measurements. The poor stability of this dye in aqueous solution, especially at the high concentrations needed for bolus injection, has been a hindrance in clinical application. However, by using carefully chosen macromolecular additives, the stability of these aqueous dye solutions may be enhanced significantly. Such noncovalent binding between dye and carrier molecules was found to preserve substantially the dye in aqueous solutions for several weeks with no apparent changes in the measured in vivo biological properties.
Comprehensive Circuit Failure Prediction for Logic and SRAM Using Virtual Aging (2015)

This article develops a comprehensive technique for failure prediction in the field for many-core processors to address wear out in harsh environments for logic and static RAM (SRAM). The authors develop three principles. First, virtually aging a processor by momentarily reducing its voltage exposes wear-out failure. Second, sampled redundancy can be used to capture logic wear-out failures because their underlying fault model is delay faults, which makes them poorly suited for using test-vector-based techniques. Third, wear out on SRAMs decreases their noise margin, and the end results can be effectively modeled as a stuck-at fault, thus allowing asymmetric checkers like built-in self-test to work effectively. The authors' design comprises two components (Aged-SDMR, which combines sampling and dual-modular redundancy, and Aged-AsymChk, which uses an asymmetric checker); has a simple implementation; and delivers low complexity, low overheads, and high accuracy. In addition to ensuring no corruptions or missed errors from wear-out failures, the full system predicts failures within 0.4 days for logic and within milliseconds for SRAM after their appearance. Furthermore, compared to SRAMs protected only with error-correcting code and decommissioned on first failure, the authors extend lifetime by 14 months on average.