gebhart/patrepeval huggingface dataset:
DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor (2018)

Cullin-RING ligases (CRLs) comprise a large group of modular eukaryotic E3 ubiquitin ligases. Within this family, the CRL4 ligase (consisting of the Cullin4 [CUL4] scaffold protein, the Rbx1 RING finger domain protein, the DNA damage-binding protein 1 [DDB1], and one of many DDB1-associated substrate receptor proteins) has been intensively studied in recent years due to its involvement in regulating various cellular processes, its role in cancer development and progression, and its subversion by viral accessory proteins. Initially discovered as a target for hijacking by the human immunodeficiency virus accessory protein r, the normal targets and function of the CRL4 substrate receptor protein DDB1-Cul4-associated factor 1 (DCAF1; also known as VprBP) had remained elusive, but newer studies have begun to shed light on these questions. Here, we review recent progress in understanding the diverse physiological roles of this DCAF1 in supporting various general and cell type-specific cellular processes in its context with the CRL4 E3 ligase, as well as another HECT-type E3 ligase with which DCAF1 also associates, called EDD/UBR5. We also discuss emerging questions and areas of future study to uncover the dynamic roles of DCAF1 in normal physiology.
Three-Dimensional Structure of <i>Escherichia coli</i> Dihydrodipicolinate Reductase in Complex with NADH and the Inhibitor 2,6-Pyridinedicarboxylate<sup>,</sup> (1997)

Dihydrodipicolinate reductase catalyzes the NAD(P)H-dependent reduction of the alpha,beta-unsaturated cyclic imine dihydrodipicolinate to form the cyclic imine tetrahydrodipicolinate. The enzyme is a component of the biosynthetic pathway that leads to diaminopimelate and lysine in bacteria and higher plants. Because these pathways are unique to microorganisms and plants, they may represent attractive targets for new antimicrobial or herbicidal compounds. The three-dimensional structure of the ternary complex of Escherichia coli dihydrodipicolinate reductase with NADH and the inhibitor 2,6-pyridinedicarboxylate has been solved using a combination of molecular replacement and noncrystallographic symmetry averaging procedures and refined against 2.6 A resolution data to a crystallographic R-factor of 21.4% (Rfree is 29.7%). The native enzyme is a 120 000 molecular weight tetramer of identical subunits. The refined crystallographic model contains a tetramer, three molecules of NADH, three molecules of inhibitor, one phosphate ion, and 186 water molecules per asymmetric unit. Each subunit consists of two domains connected by two flexible hinge regions. While three of the four subunits of the tetramer have a closed conformation, in which the nicotinamide ring of the cofactor bound to the N-terminal domain and the reducible carbon of the substrate bound to the substrate binding domain are about 3.5 A away, the fourth subunit is unliganded and shows an open conformation, suggesting that the enzyme undergoes a major conformational change upon binding of both substrates. The residues involved in binding of the inhibitor and the residues involved in catalysis have been identified on the basis of the three-dimensional structure. Site-directed mutants have been used to further characterize the role of these residues in binding and catalysis. A chemical mechanism for the enzyme, based on these and previously reported data, is proposed.
Decomposition and Stabilization of Drugs. XV. Structure and Stability of Aminoalkylesters. (7) (1976)

The diethylaminoethyl esters of ortho-, para- and di-substituted benzoic acid were synthesized and the effect of a substituent on the rate of hydrolysis in an aqueous buffer was examined. The hydrolysis rate constants were lower in the case of electron-releasing substituents and greater in the case of electron-attracting substituents in relatively higher pH solutions. There was a straight linear relationship between the Hammett substituent constant (σ) with the log (kOH/kOHo) values for the specific base-catalyzed hydrolysis of 2-diethylaminoethyl para-substituted benzoates (Fig. 4).
Current concepts on active immunization against respiratory syncytial virus for infants and young children (2002)

Respiratory syncytial virus (RSV) is the most important causative agent of viral respiratory tract infections in infants and young children. Passive immunization against RSV became available recently, but this does not apply to an effective vaccine as a result of dramatic adverse results of immunization with a RSV candidate vaccine in the 1960s and the lack of full knowledge of the immune response induced by RSV. Nonetheless intensive research during the past two decades has resulted in several interesting candidate vaccines, of which some have gone through testing in humans. These include the subunit vaccines PFP-1, PFP-2, BBG2Na and cold-passaged/temperature-sensitive mutants. The development of candidate vaccines against RSV is discussed. Because of questions, uncertainties and difficulties with the development of effective vaccines against RSV, it will probably be at least another 5 to 10 years before routine immunization against RSV becomes available.
Traumatisme et névrose de l’adolescence (2021)

En proposant dans ce chapitre de considérer que c’est tout l’infantile qui est relu, faisant ainsi événement pubertaire traumatique, nous tentons d’établir une généralisation de la théorie du traumatisme donnant sens à l’événement pubertaire, à son effet de seuil. C’est la réécriture du sexuel, inhérente à l’événement et à l’effraction pubertaire, qui crée une forme de traumatisme : «traumatisme par séduction» que le processus d’adolescence élabore ou traduit en névrose. Le processus d’adolescence névrotise la violence inhérente et à l’effraction pubertaire et à l’événement pubertaire : effraction et événement pubertaires pouvant être entendus comme les facteurs actuels et infantiles d’une névrose traumatique « normale » qui se constituerait sur ces facteurs élémentaires du pubertaire. La violence de l’adolescence s’élabore dans la grande majorité des parcours d’adolescence, le processus d’adolescence s’y déploie, suite à cette réaction traumatique pubertaire, pour en transformer la violence. Cette transformation se joue, notamment, dans la trajectoire singulière de la « réinvention d’une sexualité » vers la rencontre de l’autre sexe; trajectoire sur laquelle la créativité, le rôle des fantasmes pubertaires et leur traversée sont des itinéraires nécessaires. C’est la rencontre avec la nouveauté que porte en lui l’autre sexe qui crée un effet de complémentarité, une destination libidinale « réussie » où l’un et l’autre sexe « s’entreconjoignent ». La violence de l’adolescence trouve ainsi une voie de transformation capable d’opérer un véritable changement de registre, soit le passage du phallique au génital.
Progelatinase B Forms from Human Neutrophils. Complex Formation of Monomer/Lipocalin with TIMP-1 (1996)

The three forms of neutrophil gelatinase B-monomer, homodimer and monomer/lipocalin complex-, were isolated from phorbolester stimulated neutrophil granulocytes by chromatography on gelatin-Sepharose and heparin-Ultrogel. On average, about 50% of the monomer/lipocalin complex was found to be complexed with TIMP-1. After activation with trypsin monomer, homodimer and monomer/lipocalin complex displayed a specific activity of about 2000 mU/mg towards the substrate N-(2,4)-dinitrophenyl-Pro-Gln-Gly-lle-Ala-Gly-Gln-D-Arg, whereas the monomer/lipocalin/TIMP-1 complex could be activated to a specific activity of only 200 mU/mg. The ternary monomer/lipocalin/TIMP-1 complex behaves like the progelatinase A-TIMP-2 complex and the progelatinase B-TIMP-1 complex in that it is an inhibitor for active metalloproteinases (MMPs) and, after activation, a gelatinase with a pronouncedly reduced activity. When the monomer/lipocalin/TIMP-1 complex inhibits an MMP, a quaternary complex monomer/lipocalin/TIMP-1/MMP is generated which after activation shows a sixfold higher proteolytic activity than the active ternary complex.
Performance and fouling characteristics of a submerged anaerobic membrane bioreactor for kraft evaporator condensate treatment (2010)

Submerged anaerobic membrane bioreactor (SAnMBR) technology was studied for kraft evaporator condensate treatment at 37 +/- 1 degrees C over a period of 9 months. Under tested organic loading rates of 1-24 kg COD/m3/day, a chemical oxygen demand (COD) removal efficiency of 93-99% was achieved with a methane production rate of 0.35 +/- 0.05 L methane/g COD removed and a methane content of 80-90% in produced biogas. Bubbling of recycled biogas was effective for in-situ membrane cleaning, depending on the biogas sparging rate used. The membrane critical flux increased and the membrane fouling rate decreased with an increase in the biogas sparging rate. The scanning electron microscopy images showed membrane pore clogging was not significant and sludge cake formation on the membrane surface was the dominant mechanism of membrane fouling. The results suggest that the SAnMBR is a promising technology for energy recovery from kraft evaporator condensate.
Important Pharmacogenetic Information for Drugs Prescribed During the SARS‐CoV‐2 Infection (COVID‐19) (2020)

In December 2019, the severe acute respiratory syndrome virus-2 pandemic began, causing the coronavirus disease 2019. A vast variety of drugs is being used off-label as potential therapies. Many of the repurposed drugs have clinical pharmacogenetic guidelines available with therapeutic recommendations when prescribed as indicated on the drug label. The aim of this review is to provide a comprehensive summary of pharmacogenetic biomarkers available for these drugs, which may help to prescribe them more safely.
Molecular dynamics Simulation for analysis of surface morphology of lubricant films with functional end Groups (2005)

Coarse-grained molecular dynamics (MD) simulations were applied to reproduce the surface morphology of lubricant films with functional end groups on solid surfaces. By introducing a molecular-probe scanning method analogous to scanning probe microscopy, we quantitatively studied the effects of end-group functionality and polymer length on the surface morphology at a molecular scale resolution. We clarified that the lubricant film surface became rougher for stronger interactions between end groups and for shorter polymer lengths, and the morphology was correlated with the end-group distribution inside the films.
On pending interest table in named data networking (2012)

Internet has witnessed its paramount function transition from host-to-host communication to content dissemination. Named Data Networking (NDN) and Content-Centric Networking (CCN) emerge as a clean slate network architecture to embrace this shift. Pending Interest Table (PIT) in NDN/CCN keeps track of the Interest packets that are received but yet un-responded, which brings NDN/CCN significant features, such as communicating without the knowledge of source or destination, loop and packet loss detection, multipath routing, better security, etc. This paper presents a thorough study of PIT for the first time. Using an approximate, application-driven translation of current IP-generated trace to NDN trace, we firstly quantify the size and access frequencies of PIT. Evaluation results on a 20 Gbps gateway trace show that the corresponding PIT contains 1.5 M entries, and the lookup, insert and delete frequencies are 1.4 M/s, 0.9 M/s and 0.9 M/s, respectively. Faced with this challenging issue and to make PIT more scalable, we further propose a Name Component Encoding (NCE) solution to shrink PIT size and accelerate PIT access operations. By NCE, the memory consumption can be reduced by up to 87.44%, and the access performance significantly advanced, satisfying the access speed required by PIT. Moreover, PIT exhibits good scalability with NCE. At last, we propose to place PIT on (egress channel of) the outgoing line-cards of routers, which meets the NDN design and eliminates the cumbersome synchronization problem among multiple PITs on the line-cards.
Securing distributed computing against the hostile host (2004)

Distributed computing is evolving into a collection of different paradigms that involve multiple organisations. These include mobile agents, e-Science applications such as SETI@Home or Folding@Home, and grid computing. Security is a major concern in a multi-organizational setting. To date attention has focused on authentication of participants and authorization to use resources. Protection of hosts and processes executing on those hosts have been left to the local operating system security.In this paper we consider the security of a visiting computation with respect to a possibly hostile host. Any part of the data used by a computation, the results of the computation or the code itself may represent valuable intellectual property to its owner. The correctness of the computation may be essential to some larger, critical process.The paper presents a methodology based on anchors of trust that allowed us to study the security dependencies within a Unix like operating system. We have identified a small set of vulnerabilities that could be exploited to create a hostile host capable of attacking a visiting computation. We show that minor extensions to a processor's microcode can be used to remove these vulnerabilities. While we can never completely remove the threat of a hostile host the proposed extensions significantly increase the work required to corrupt a host.
Eschatology, Infinite Series, and Reliability (1982)

This communication is concerned with a most timely problem. Early warning systems against ICBM-attacks now and then cause false alarms which in turn can trigger a retaliatory ICBM attack. Up until now any retaliatory attacks have been stopped before any consequences have resulted. I try to compute the joint probability of infinitely many false alarms being detected before serious consequences have resulted.
A stretchable polysiloxane elastomer with self-healing capacity at room temperature and solvatochromic properties (2017)

A stretchable silicon elastomer comprising cobalt ions in pyridine pendant polydimethylsiloxane (PDMS) was prepared. Different from previously reported cobalt-coordinated elastomers, these elastomers are self-healable at room temperature with a high healing efficiency of over 90%. Besides, they exhibit tailored solvatochromic properties over a wide range without sacrificing its self-healing ability at room-temperature.
Energy eigenstates of magnetostatic waves and oscillations (2001)

Effect of excitation of magnetostatic oscillations in a ferrite resonator by the microwave magnetic field was a subject of many publications of more than the last 40 years. The most interesting multiresonance spectrum of absorption peaks one can observe experimentally is a case of disk-form small ferrite resonators. It is shown in this paper that such small ferrite resonators can be considered as "artificial molecular structures" with properties characterized by energy eigenstates of magnetostatic oscillations. A special interest in these properties may be found in the field of microwave artificial composite materials.
Oil Sands MFT Properties and Freeze-Thaw Effects (2012)

This paper presents a framework for combining the chemistry and mineralogy of oil sands mature fine tailings (MFT) along with geotechnical knowledge of freeze-thaw processes, large strain consolidation and MFT behavior to develop a conceptual model incorporating the physicochemical processes associated with freeze-thaw dewatering. A conceptual model of freeze-thaw dewatering of oil sands MFT is proposed, which accounts for the release of water, change in mechanical and hydraulic properties, and alteration of the micro and macrofabric of MFT under one-dimensional conditions. Various solutions to the Neumann thermal model were examined to assess their ability to predict the rate of freezing and thawing of MFT. Models for predicting thaw and postthaw settlement were discussed as they pertain to freeze-thaw dewatering of MFT.
The AI Business: Commercial Uses of Artificial Intelligence (1986)

What is the bottom line on Artificial Intelligence? The AI Business offers a comprehensive summary of the commercial picture, present and future, for Artificial Intelligence in the computer industry, medicine, the oil industry, and electronic design. AI's brightest and best -- financiers, researchers, and users -- analyze current projects, speculate on trends in factory automation, compare research in Japan and the U.S., and note the pros and cons of investment opportunities.Contents: Expert Systems. Amplifying Expertise with Expert Systems, Randall Davis (MIT). XCON: An Expert Configuration System at Digital Equipment Corporation, Arnold Kraft (DEC). DIPMETER ADVISOR: An Expert Logo Analysis System at Schlumberger, James D. Baker (Schlumberger). CADUCEUS: An Experimental Expert System for Medical Diagnosis, Harry E. Pople, Jr. (University of Pittsburgh). The Low Road, the Middle Road, and the High Road, John Seely Brown (Xerox).Work and Play. Inventing the Future, Alan Kay (Atari). The Engineer's Apprentice, Aryeh Finegold (Daisy Systems Corporation). The Programmer's Apprentice, Charles Rich (MIT). Intelligent Advisory Systems, Roger Schank (Cognitive Systems, Inc. and Yale University). Natural Language Front Ends, Larry R. Harris (Artificial Intelligence Corporation).Robotics. Intelligent Robots: Connecting Perception to Action, ). Michael Brady (MIT). Intelligent Robots: Moving toward Megassembly, Philippe Villers (Automatix, Inc.). Intelligent Robots: Myth or Reality, Paul M. Russo (GE).Today and Tomorrow. The Problems and the Promise, Marvin Minsky (MIT). An Investment Opportunity? Frederick R. Adler (Adler & Company). Financing the Future, William H. Janeway (F. Eberstadt & Co., Inc.) From the Blocks World to the Business World, Patrick H. Winston and Karen A. Prendergast (MIT). How to Learn More.
Nucleic Acid Polymers Are Active against Hepatitis Delta Virus Infection<i>In Vitro</i> (2017)

In this study, an <i>in vitro</i> infection model for the hepatitis delta virus (HDV) was used to evaluate the antiviral effects of phosphorothioate nucleic acid polymers (NAPs) and investigate their mechanism of action. The results show that NAPs inhibit HDV infection at concentrations less than 4 μM in cultures of differentiated human hepatoma cells. NAPs were shown to be active at viral entry but inactive postentry on HDV RNA replication. Inhibition was independent of the NAP nucleotide sequence but dependent on both size and amphipathicity of the polymer. NAP antiviral activity was effective against HDV virions bearing the main hepatitis B virus (HBV) immune escape substitutions (D144A and G145R) and was pangenomic with regard to HBV envelope proteins. Furthermore, similar to immobilized heparin, immobilized NAPs could bind HDV particles, suggesting that entry inhibition was due, at least in part, to preventing attachment of the virus to cell surface glycosaminoglycans. The results document NAPs as a novel class of antiviral compounds that can prevent HDV propagation.<b>IMPORTANCE</b> HDV infection causes the most severe form of viral hepatitis in humans and one of the most difficult to cure. Currently, treatments are limited to long-term administration of interferon at high doses, which provide only partial efficacy. There is thus an urgent need for innovative approaches to identify new antiviral against HDV. The significance of our study is in demonstrating that nucleic acid polymers (NAPs) are active against HDV by targeting the envelope of HDV virions. In an <i>in vitro</i> infection assay, NAP activity was recorded at concentrations less than 4 μM in the absence of cell toxicity. Furthermore, the fact that NAPs could block HDV at viral entry suggests their potential to control the spread of HDV in a chronically HBV-infected liver. In addition, NAP anti-HDV activity was pangenomic with regard to HBV envelope proteins and not circumvented by HBsAg substitutions associated with HBV immune escape.
Design of broadband transitions from microstripto slotline (1994)

Practical limitations in the design of very broadband transitions from microstrip to slotline are due to the limited realisability of high characteristic impedance slotline stubs and low characteristic impedance microstrip stubs. It is shown how such limitations may be alleviated by the use of junctions of stubs. Two tandem connected transitions employing this idea exhibit, in the frequency band 1–10 GHz, an insertion loss less than 1.5 dB.
Basal and stimulated gastrin and pepsinogen levels after eradication of Helicobacter pylori (1999)

(1) Measurement of gastrin and PG levels (especially basal PGII values) is a useful non-invasive method to confirm H. pylori eradication after therapy. (2) H. pylori eradication is associated with a significant decrease in basal and stimulated gastrin levels and in basal PGII levels that is detected immediately (1 month) after finishing treatment, and remains unchanged for 1 year. However, the decrease in basal and stimulated PGI levels occurs progressively for 6 months, although such levels remain also unchanged afterwards. (3) Measurement of gastrin and PGI concentrations has a limited usefulness in the diagnosis of H. pylori reinfections after successful eradication, although PGII determination could be more useful in this situation.
Complex-forming poly(oxyethylene)/poly(acrylic acid) interpenetrating polymer networks. 2. Function as a chemical valve (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplex-forming poly(oxyethylene)/poly(acrylic acid) interpenetrating polymer networks. 2. Function as a chemical valveShiro Nishi and Tadao KotakaCite this: Macromolecules 1986, 19, 4, 978–984Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ma00158a007https://doi.org/10.1021/ma00158a007research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts