gebhart/patrepeval huggingface dataset:
Improved Back-Side Purge-Gas Chambers For Plasma Arc Welding (1995)

'Legacy Mentors' are nurses aged 55 or older with a wealth of knowledge and passion to share with other nurses. Finding ways to capture their wisdom, disseminate their expertise, and potentially retain them longer is critical. As part of an innovative Educator Pathway project in two health authorities in British Columbia, Canada, nurses with up to 40 years of experience proposed to share their wisdom and translate their expertise for the next generation of nurses. The Legacy Mentor Project involved 29 nurses who developed projects to share knowledge with students, novice and experienced nurses in their work settings. The project included an orientation workshop to facilitate project start-up, a mid-way workshop for sharing progress, and a celebration event in September 2009 which highlighted their learning and final outcomes in. Project evaluation through surveys, focus groups and interviews revealed that the nurses' expertise was validated, suggesting that the translation of expertise by re-energized nurses is a strategy with potential to enhance retention of our most experienced nurses while also enhancing practice learning environments. Unexpected outcomes were reciprocal learning and changing practice of nursing peers through modelling and discussion. This paper will describe the process and outcomes of this pilot project, including description of the projects completed by the Legacy Mentors.
Absolute distance sensing by two laser optical interferometry (2013)

We have developed a method for absolute distance sensing by two laser optical interferometry. A particularity of this technique is that a target distance is determined in absolute and is no longer limited to within an ambiguity range affecting usually multiple wavelength interferometers. We implemented the technique in a low-finesse Fabry-Pérot miniature fiber based interferometer. We used two diode lasers, both operating in the 1550 nm wavelength range. The wavelength difference is chosen to create a 25 μm long periodic beating interferometric pattern allowing a nanometer precise position measurement but limited to within an ambiguity range of 25 μm. The ambiguity is then eliminated by scanning one of the wavelengths over a small range (3.4 nm). We measured absolute distances in the sub-meter range and this with just few nanometer repeatability.
Hybrid Cloud Placement Algorithm (2014)

A fully functional hybrid cloud solution requires a placement service to automatically decide whether an application should be deployed on premise, in a public cloud, or across private and public clouds. Such a service must consider application structure and communication patterns, application affinity requirements, which usually result from data protection rules, and deployment costs. In this paper, we propose a hybrid cloud placement approach which addresses these challenges. Our approach considers application requirements, cost, and private cloud capacity. Further, it is tunable to allow for changing application patterns and business objectives and offers a useful trade-off between application QoS and its deployment cost.
<i>In situ</i> measurement of leaf chlorophyll concentration: analysis of the optical/absolute relationship (2014)

In situ optical meters are widely used to estimate leaf chlorophyll concentration, but non-uniform chlorophyll distribution causes optical measurements to vary widely among species for the same chlorophyll concentration. Over 30 studies have sought to quantify the in situ/in vitro (optical/absolute) relationship, but neither chlorophyll extraction nor measurement techniques for in vitro analysis have been consistent among studies. Here we: (1) review standard procedures for measurement of chlorophyll; (2) estimate the error associated with non-standard procedures; and (3) implement the most accurate methods to provide equations for conversion of optical to absolute chlorophyll for 22 species grown in multiple environments. Tests of five Minolta (model SPAD-502) and 25 Opti-Sciences (model CCM-200) meters, manufactured from 1992 to 2013, indicate that differences among replicate models are less than 5%. We thus developed equations for converting between units from these meter types. There was no significant effect of environment on the optical/absolute chlorophyll relationship. We derive the theoretical relationship between optical transmission ratios and absolute chlorophyll concentration and show how non-uniform distribution among species causes a variable, non-linear response. These results link in situ optical measurements with in vitro chlorophyll concentration and provide insight to strategies for radiation capture among diverse species.
Improved Expansion and In Vivo Function of Patient T Cells by a Serum-free Medium (2017)

Improvements to T cell culture systems that promote long-term engraftment and function of adoptively transferred T cells will likely result in superior clinical benefit to more individuals. To this end, we recently developed a chemically defined cell culture medium that robustly expands all T cell subsets in the absence of human serum. Using a humanized mouse model, we observed that T cells expanded in the absence of human serum provided durable control of tumors, whereas T cells expanded in medium supplemented with human serum only mediated transient control of tumor growth. Importantly, our new medium effectively expanded more differentiated T cells from multiple myeloma patients in the absence of serum. These patient-derived T cells were also able to provide durable control of B cell tumors <i>in vivo</i>, and this long-term control of cancer was lost when T cells were expanded in the presence of serum. Thus, engineered T cells expanded in an optimized medium in the absence of serum may have improved therapeutic potential.
Role of Zymogenicity-Determining Residues of Coagulation Factor VII/VIIa in Cofactor Interaction and Macromolecular Substrate Recognition (2002)

Factor VIIa (VIIa) remains in a zymogen-like state following proteolytic activation and depends on interactions with the cofactor tissue factor (TF) for function. Val(21), Glu(154), and Met(156) are residues that are spatially close in available zymogen and enzyme structures, despite major conformational differences in the corresponding loop segments. This residue triad displays unusual side chain properties in comparison to the properties of other coagulation serine proteases. By mutagenesis, we demonstrate that these residues cooperate to stabilize the enzyme conformation and to enhance the affinity for TF. In zymogen VII, however, substitution of the triad did not change the cofactor affinity, further emphasizing the crucial role of the activation pocket in specifically stabilizing the active enzyme conformation. In comparison to VIIa(Q156), the triple mutant VIIa(N21I154Q156) had a stabilized amino-terminal Ile(16)-Asp(194) salt bridge and enhanced catalytic function. However, proteolytic and amidolytic activities of free VIIa variants were not concordantly increased. Rather, a negatively charged Asp at position 21 was the critical factor that determined whether an amidolytically more active VIIa variant also more efficiently activated the macromolecular substrate. These data thus demonstrate an unexpected complexity by which the zymogenicity-determining triad in the activation pocket of VIIa controls the active enzyme conformation and contributes to exosite interactions with the macromolecular substrate.
Use of the Soluble Peptide γ‐L‐Glutamyl‐L‐Tyrosine to Provide Tyrosine in Total Parenteral Nutrition in Rats (1993)

Limited solubility restricts amounts of tyrosine (Tyr) in amino acid solutions used in total parenteral nutrition (TPN). Excess phenylalanine (Phe) is included in TPN for conversion to Tyr by liver Phe hydroxylase. However, this conversion is limited, especially in infants. We have confirmed that infants receiving TPN have low Tyr concentrations and high Phe/Tyr ratios in plasma compared with published values for enterally fed neonates. Tyr is important in the synthesis of proteins and other biomolecules, including catecholamines in the brain. We tested the soluble peptide gamma-glutamyl-tyrosine (Glu(Tyr)) as a possible precursor of Tyr in TPN. Groups of five rats were given infusions of TPN containing an amino acid mixture simulating a commercial formulation (group A), TPN in which Glu(Tyr) was substituted for half the Phe in the group A solution) (group B), or saline (group C). Control animals (group C) were fed rodent chow. Blood was sampled at 0 time and daily for 4 days. Brains were collected at 96 hours, and aromatic amino acids in plasma and brains were measured by high-performance liquid chromatography. Throughout the experiment, plasma of animals in group A had significantly elevated Phe and reduced Tyr concentrations compared with control values; plasma concentrations in groups B and C were similar. In groups A and B, brain Tyr levels were 31% and 63% of control values, respectively. In group B, Glu(Tyr) was not detected in brains. These data suggest that supplementing current TPN mixtures with Glu(Tyr), which is stable in solution, can produce normal plasma Tyr concentrations and Phe/Tyr ratios and improve the supply of Tyr to the brain.
Heparins Designed to Specifically Inhibit Platelet Interactions With von Willebrand Factor (1996)

Subspecies of heparin can be developed with significantly enhanced potency to inhibit vWF/platelet interactions. The vWF-inhibiting property of heparin can be dissociated from its antithrombin-binding activity. Based on a growing understanding of heparin/vWF interactions, combinations of affinity separations and chemical modifications could be designed to yield heparins uniquely suitable for prevention of arterial thrombosis.
A procedure for optimally removing localized coherent noise (1995)

Abstract Primary reflections in seismic records are often obscured by coherent noise making processing and interpretation difficult. Trapped water modes, surface waves, scattered waves, air waves, and tube waves to name a few, must be removed early in the processing sequence to optimize subsequent processing and imaging.We have developed a noise canceling algorithm that effectively removes many of the commonly encountered noise trains in seismic data. All currently available techniques for coherent noise attenuation suffer from limitations that introduce unacceptable signal distortions and artifacts. Also, most of those techniques impose the dual stringent requirements of equal and fine spatial sampling in the field acquisition of seismic data. Our technique takes advantage of characteristics usually found in coherent noise such as being localized in time, highly aliased, nondispersive (or only mildly so), and exhibit a variety of moveout patterns across the seismic records.When coherent noise is localized in time, a window much like a surgical mute is drawn around the noise. The algorithm derives an estimate of the noise in the window, automatically correcting for amplitude and phase differences, and adaptively subtracts this noise from the window of data. This signal estimate is then placed back in the record.In a model and a land data example, the algorithm removes noise more effectively with less signal distortion than does f-k filtering or velocity notch filtering. Downgoing energy in a vertical seismic profile (VSP) with irregular receiver spacing is also removed.
Design and Semisynthesis of Novel Fredericamycin A Derivatives with an Improved Antitumor Profile. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Magnetic Field Effect on High T<sub>c</sub> Superconductive Films (1988)

Thin film fabrication has an important role to play as a means of clarifying the basic physical properties of high-temperature superconductors. For instance, when epitaxial film growth techniques are used, crystal axes are aligned far more easily than in the bulk state, facilitating the measurement of physical properties. It is the that superconducting materials so dense that they have a critical current as high as 107 A/cm{sup 2} can be fabricated. And, if high-temperature superconducting layers could be formed epitaxially on metals, semiconductors, insulators, and magnetic materials with a junction scale of order {lambda}GL and {xi}, the method would be open for new types of superconducting devices. In this report, the authors describe thin superconducting films formed on a metal buffer layer.
Adapalene 0.1% and benzoyl peroxide 2.5% as a fixed-dose combination gel is as well tolerated as the individual components alone in terms of cumulative irritancy. (2008)

International guidelines recommend the combination of retinoids (e.g. adapalene, tazarotene) and benzoyl peroxide for treating acne because of their complementary mechanisms of action. A new fixed-dose combination gel of adapalene 0.1% and benzoyl peroxide (BPO) 2.5% (adapalene/BPO*) is an effective acne treatment and offers the advantage of a once daily application. This paper reports the results of a cumulative irritancy study in healthy volunteers comparing adapalene/BPO to adapalene 0.1% and BPO 2.5% applied separately, BPO 10% gel, tazarotene 0.1% gel and the gel vehicle as a control.There was no significant difference between the mean cumulative irritation index (MCII) for adapalene/BPO and any test product except tazarotene 0.1% gel, which had a significantly greater MCII than all other test products (p < 0.05). This study showed that adapalene/BPO as a fixed-dose combination is as well tolerated as BPO 2.5% gel alone or adapalene 0.1% gel alone in terms of cumulative irritancy.*Epiduo, Galderma S.A.
Transistor Sizing for Parameter Obfuscation of Analog Circuits Using Satisfiability Modulo Theory (2018)

In this paper, an approach is described for enhancing the security of analog circuits using Satisfiability Modulo Theory (SMT) based design space exploration. The technique takes as inputs generic circuit equations and performance constraints and, by exhaustively exploring the design space, outputs transistor sizes that satisfy the given constraints. The analog satisfiability (aSAT) methodology is applied to parameter biasing obfuscation, where the width of a transistor is obfuscated to mask circuit properties, while also limiting the number of keys that produce the target performance requirements. The proposed methodology is used in the design of a differential amplifier and a two stage amplifier. The widths determined through aSAT analysis are shown to meet the gain, phase margin, and power consumption requirements for both a differential amplifier and a two-stage amplifier. However, a 7 MHz offset in the gain-bandwidth of the two-stage amplifier is observed from the target value of 30 MHz. The total gain of the two stage amplifier is masked with a 24 bit encryption key that results in a probability of 5.96×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-08</sup> to determine the correct key. The simulated results indicate that the proposed analog design methodology quickly and accurately determines transistor sizes for target specifications, while also accounting for obfuscation of analog circuit parameters.
Theoretical Analysis of Accommodation Amplitude and Ametropia Correction by Varying Refractive Index in Phaco-Ersatz (2001)

Phaco-Ersatz is a surgical procedure for restoring accommodation in which the presbyopic crystalline lens is replaced by a flexible polymer gel in the lens capsule. We assessed the feasibility of simultaneously correcting ametropia while restoring accommodation using Phaco-Ersatz by utilizing polymer gel of the appropriate refractive index. Computation results using paraxial equations and ray tracing on two model eyes indicate that although this approach might be feasible for the hypermetrope, its usefulness for correcting myopia is limited, principally due to significant reductions in the resultant amplitude of accommodation.
A self-referencing biosensor based upon a dual-mode external cavity laser (2013)

To improve the ability of an external cavity laser (ECL) biosensor to more easily distinguish true signals caused by biomolecular binding from a variety of sources of background noise, two photonic crystal (PC) resonant reflectors were incorporated into a single flow cell, with one of the PCs performing the detection function and the other one serving as a reference sensor. The ECL-based sensor system simultaneously emits at two distinct wavelengths corresponding to two different longitudinal cavity modes selected by the sensing and reference PC reflectors. The surface of the sensing PC filter was functionalized by a biomolecule recognition layer and exhibited narrowband reflection with the peak reflection wavelength at 856 nm. The reference PC was untreated and had the peak reflection wavelength at 859 nm. The PCs were bond to the upper and lower surfaces of a thin chamber frame, forming a flow cell. Utilizing the reference external cavity mode, the dual-mode ECL sensor system eliminated common-mode noise sources, including thermal drift, refractive index variations of the analyte solution, and nonspecific biomolecule binding.
I/O efficient algorithms for serial and parallel suffix tree construction (2010)

Over the past three decades, the suffix tree has served as a fundamental data structure in string processing. However, its widespread applicability has been hindered due to the fact that suffix tree construction does not scale well with the size of the input string. With advances in data collection and storage technologies, large strings have become ubiquitous, especially across emerging applications involving text, time series, and biological sequence data. To benefit from these advances, it is imperative that we have a scalable suffix tree construction algorithm. The past few years have seen the emergence of several disk-based suffix tree construction algorithms. However, construction times continue to be daunting—for example, indexing the entire human genome still takes over 30 hours on a system with 2 gigabytes of physical memory. In this article, we will empirically demonstrate and argue that all existing suffix tree construction algorithms have a severe limitation—to glean reasonable disk I/O efficiency, the input string being indexed must fit in main memory. This limitation is attributed to the poor locality exhibited by existing suffix tree construction algorithms and inhibits both sequential and parallel scalability. To deal with this limitation, we will show that through careful algorithm design, one of the simplest suffix tree construction algorithms can be rearchitected to build a suffix tree in a tiled manner, allowing the execution to operate within a fixed main memory budget when indexing strings of any size. We will also present a parallel extension of our algorithm that is designed for massively parallel systems like the IBM Blue Gene. An experimental evaluation will show that the proposed approach affords an improvement of several orders of magnitude in serial performance when indexing large strings. Furthermore, the proposed parallel extension is shown to be scalable—it is now possible to index the entire human genome on a 1024 processor IBM Blue Gene system in under 15 minutes.
<title>Real-time high-resolution PC-based system for measurement of errors on compact disks</title> (1994)

Hardware and software utilities are developed to directly monitor the Eight-to-Fourteen (EFM) demodulated data bytes at the input of a CD player's Cross-Interleaved Reed-Solomon Code (CIRC) block decoder. The hardware is capable of identifying erroneous data with single-byte resolution in the serial data stream read from a Compact Disc by a CDD 461 Philips CD-ROM drive. In addition, the system produces graphical maps that show the physical location of the measured errors on the entire disc, or via a zooming and planning feature, on user selectable local disc regions.
<title>The Free Electron Laser</title> (1978)

We review the status of our research on the Free Electron Laser© (1978) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Use of electron-trapping materials in optical signal processing IV: Parallel incoherent image subtraction (1993)

Novel electron trapping materials are inherently capable of performing subtraction over a wide dynamic range. The application of the electron trapping materials to parallel incoherent image subtraction is described in detail, and experimental results are presented.
Efficient Perovskite Solar Cells Fabricated by Co Partially Substituted Hybrid Perovskite (2018)

Abstract In the past years, hybrid perovskite materials have attracted great attention due to their superior optoelectronic properties. In this study, the authors report the utilization of cobalt (Co 2+ ) to partially substitute lead (Pb 2+ ) for developing novel hybrid perovskite materials, CH 3 NH 3 Pb 1‐ x Co x I 3 (where x is nominal ratio, x = 0, 0.1, 0.2 and 0.4). It is found that the novel perovskite thin films possess a cubic crystal structure with superior thin film morphology and larger grain size, which is significantly different from pristine thin film, which possesses the tetragonal crystal structure, with smaller grain size. Moreover, it is found that the 3d orbital of Co 2+ ensures higher electron mobilities and electrical conductivities of the CH 3 NH 3 Pb 1‐ x Co x I 3 thin films than those of pristine CH 3 NH 3 Pb 4 thin film. As a result, a power conversion efficiency of 21.43% is observed from perovskite solar cells fabricated by the CH 3 NH 3 Pb 0.9 Co 0.1 I 3 thin film. Thus, the utilization of Co, partially substituting for Pb to tune physical properties of hybrid perovskite materials provides a facile way to boost device performance of perovskite solar cells.
Electrical impedance tomography of carbon nanotube composite materials (2007)

The field of nanotechnology is rapidly maturing into a fertile and interdisciplinary research area from which new sensor and actuator technologies can be conceived. The tools and processes derived from the nanotechnology field have offered engineers the opportunity to design materials in which sensing transduction mechanisms can be intentionally encoded. For example, single- and multi-walled carbon nanotubes embedded within polyelectrolyte thin films have been proposed for strain and pH sensing. While the electromechanical and electrochemical response of carbon nanotube composites can be experimentally characterized, there still lacks a fundamental understanding of how the conductivity of carbon nanotube composites is spatially distributed and how it depends on external stimuli. In this study, electrical impedance tomography is proposed for spatial characterization of the conductivity of carbon nanotube composite thin films. The method proves promising for both assessment of as-fabricated thin film quality as well as for two-dimensional sensing of thin film response to mechanical strain and exposure to pH environments.