gebhart/patrepeval huggingface dataset:
Changes in sugars during rice seed desiccation (2006)

The correlation between desiccation tolerance and soluble sugars was investigated in seeds of a number of rice cultivars belonging to the Asian rice Oryza sativa L. They were dried or ultradried to various low moisture content and then imbibed for germination testing. Few or no changes on germination percentage and vigor index were found in Indian rice seeds even after their moisture content fell to 3.5%, indicating that Indian rice exhibited a strong desiccation tolerance. On the contrary, Japonica rice seed germination percentage rapidly decreased, after their moisture content fell to 4.5%. The capacity for desiccation tolerance in Japonica (cv. Chunjiang 15) and Indian (cv. Zhongzu 1) developing seeds increased on 23–40 and 15–25 days after pollination, respectively. Though the level of monosaccharides declined, the content of sucrose has increased during desiccation. These results suggest that desiccation tolerance might be associated with the increase in seed viability and the changes in sugar level, and that raffinose could be capable of contributing to the desiccation tolerance to ultradrying.
Multiple-Valued Logic Charge-Coupled Devices (1981)

A new method to implement multiple-valued logic in large scale integrated circuits is introduced. The data are represented by discrete amounts of charge in a charge-coupled device. In this paper the design principles and realizations in four-valued logic of a minimum and maximum circuit, a complement circuit, a literal a successor, and an adder are presented. Also, the designs of a binary-to-quaternary converter and vice versa are discussed. Charge-coupled devices offer low-power consumption, high-packing density, and the possibility to perform MOST-IC compatible multiple-valued logic in any arbitrary radix.
Underwater robot with a buoyancy control system based on the spermaceti oil hypothesis development of the depth control system (2010)

The goal of this paper is to develop a robot control system using a microcomputer for an underwater robot with a buoyancy control system based on the spermaceti oil hypothesis. Sperm whales have a spermaceti organ in their head that is filled with spermaceti oil. It is said that sperm whales control their buoyancy by melting or coagulating spermaceti oil. In the previous papers proposed an underwater robot with a buoyancy control device using its theory. The robot was radio controlled and it had no sensor. Therefore, the robot could not detect water depth. Also, it was not able to control its own depth. In addition, the robot could not dive because it had no cooling system. In this paper, we built a depth control circuit using a microcomputer and pressure sensor. The pressure sensor detected the robot's depth, and the microcomputer controlled the robot's position. And, we made a new buoyancy control device using a peltier element. A peltier element was used for heating and cooling systems of the paraffin wax. Then, we experimented with the robot control. As a result, we confirmed that when we ordered a target water depth, the robot dived, floated and maintained the depth itself by detecting its own position. In addition, we confirmed that when a disturbance occurs, the robot returned to the former depth.
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern (2021)

The durability of immune memory after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccination remains unclear. In this study, we longitudinally profiled vaccine responses in SARS-CoV-2–naïve and –recovered individuals for 6 months after vaccination. Antibodies declined from peak levels but remained detectable in most subjects at 6 months. By contrast, mRNA vaccines generated functional memory B cells that increased from 3 to 6 months postvaccination, with the majority of these cells cross-binding the Alpha, Beta, and Delta variants. mRNA vaccination further induced antigen-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells, and early CD4<sup>+</sup> T cell responses correlated with long-term humoral immunity. Recall responses to vaccination in individuals with preexisting immunity primarily increased antibody levels without substantially altering antibody decay rates. Together, these findings demonstrate robust cellular immune memory to SARS-CoV-2 and its variants for at least 6 months after mRNA vaccination.
Wavelength-Shift-Free 3R Regenerator for 40-Gb/s RZ System by Optical Parametric Amplification in Fiber (2006)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We demonstrate wavelength-shift-free 3R-regenerator for 40-Gb/s optical return-to-zero (RZ) system by optical parametric amplification (OPA) with a clock-modulated pump in highly nonlinear fiber. The power penalty is improved by 2.6 dB, and the signal power is amplified by 7 dB. </para>
Monopulse estimation with adaptive arrays (1993)

The angle estimation problem with an adaptive phased array radar is considered. Because of the adaptation, the shape of the sum and difference beam is perturbed, therefore the usual monopulse formula produces errors if applied to the adaptive sum and difference beam outputs without correction. Correction values are derived for the slope and bias of the adaptive monopulse ratio for a planar array, and it is shown by example that this corrected adaptive monopulse procedure may be applied to the subarray outputs of a large array with partial digital beamforming. The bias can be further reduced by iterating the procedure, resulting in a ‘multistep corrected adaptive monopulse procedure’. This technique is also applicable to subarray output data. The method is applicable to arbitrary planar or volume arrays.
Role of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation (2014)

Previously, we have identified the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) gene as notably hypomethylated in low-malignant potential (LMP) and high-grade (HG) serous epithelial ovarian tumors, compared to normal ovarian tissues. Here we show that GALNT3 is strongly overexpressed in HG serous EOC tumors as compared to normal ovarian tissue. Moreover, the GALNT3 expression significantly correlated with shorter progression-free survival (PFS) intervals in epithelial ovarian cancer (EOC) patients with advanced disease. Knockdown of the GALNT3 expression in EOC cells led to sharp decrease of cell proliferation and induced S-phase cell cycle arrest. Additionally, GALNT3 suppression significantly inhibited EOC cell migration and invasion. Gene expression profiling and consecutive network and pathway analyses confirmed these findings, as numerous genes and pathways known previously to be implicated in ovarian tumorigenesis, including EOC tumor invasion and metastasis, were found to be downregulated upon GALNT3 suppression, while some tumor suppressor genes were induced. Moreover, GALNT3 downregulation was associated with reduced MUC1 protein expression in EOC cells, probably related to destabilization of the MUC1 protein due to lack of GALNT3 glycosylation activity. GALNT3 knockdown was also accompanied with increase of the cell adhesion molecules β-catenin and E-cadherin, which are normally suppressed by MUC1 in cancer, thus supporting the role of the GALNT3-MUC1 axis in EOC invasion. Taken together, our data are indicative for a strong oncogenic potential of the GALNT3 gene in advanced EOC and identify this transferase as a novel EOC biomarker and putative EOC therapeutic target. Our findings also suggest that GALNT3 overexpression might contribute to EOC progression through aberrant mucin O-glycosylation.
Adsolubilization in Cationic Surfactant Bilayer Formed on Silica (1991)

シリカ粒子上に形成された陽イオン性界面活性剤 (dodecyl pyridinium chloride, DPCI;cetyl pyridiniumchloride, CPC1) の二層吸着層へのヘキサノールとスチレンの吸着可溶化挙動を, 活性剤の吸着量, ヘキサノールの吸着可溶化量, 蛍光, およびESR測定により調べた。その結果, ヘキサノールの吸着可溶化量はCPC1二層吸着層中では添加ヘキサノール濃度により増加するが, DPC1二層吸着層中ではヘキサノールの吸着可溶化はほとんどみられなかった。さらにヘキサノールの吸着可溶化によりCPC1二層吸着層中の微視的極性と微視的粘度は増加した。同様の傾向はスチレンの吸着可溶化においてもみられた。
A System Based on IoT Platforms and Occupancy Monitoring for Energy-Efficient HVAC Management (2019)

This paper presents a system based on Internet of Things (IoT) platforms for energy-efficient Heating, Ventilation and Air Conditioning (HVAC) management. The proposed solution is modular, scalable and it is able to modulate the airflow in different building areas based on the actual number of occupants. This can be monitored in real-time with no privacy issues and with no need for involved prediction models. Currently, a prototype of the proposed system is used to regulate ventilation in compliance with the requirements of the EN Standard 16798:2017. The first experimental results confirm that the proposed solution can reduce the daily electrical energy consumption of an HVAC system by about 60%, with no air quality degradation.
Annealing of metal wire by atmospheric pressure discharge plasma (2008)

A manufacturing process of fine wire is mainly consisted of 3 following processes. 1) The drawing process, 2) The cleaning process, and 3) The annealing process. In this study, the possible application of atmospheric pressure dielectric barrier discharge plasma to the annealing of metallic wire was examined and presented. The main purposes of the study are as followings; 1) to investigate the annealing effect by using the plasma, 2) to examine the surface cleaning effect for the cylindrical object by the atmospheric pressure plasma. In the previous study, it was shown that the annealing of wire was possible by the plasma. Then, it was shown that surface cleaning was also possible by the plasma exposure. From these results, the possibility of the rationalization of fine wire manufacturing process was able to be shown.
Detection of Serum IgG Antibodies Specific for<i>Wolbachia</i>Surface Protein in Rhesus Monkeys Infected with<i>Brugia malayi</i> (2001)

The mechanism of lymphedema development in individuals with lymphatic filariasis is presently poorly understood. To investigate whether Wolbachia, symbiotic bacteria living within filarial nematodes, may be involved in disease progression, Wolbachia-specific immune responses were assayed in a group of Brugia malayi-infected rhesus monkeys. Serum IgG antibodies specific for a major Wolbachia surface protein (WSP) were detected in 2 of 12 infected monkeys. It is interesting that both of these monkeys developed lymphedema after becoming amicrofilaremic. WSP-specific antibody responses were temporally associated with increases in antifilarial IgG1 antibodies as well as lymphedema development. These findings suggest that Wolbachia may be important in understanding disease caused by filarial worms.
Natural History of β-Cell Dysfunction in NIDDM (1990)

Non-insulin-dependent diabetes mellitus (NIDDM) is characterized by insulin resistance and beta-cell dysfunction. This review focuses on the beta-cell, what defects occur when and why. Two major anatomic observations have been made in NIDDM. The beta-cell mass is mildly reduced, especially when obesity is taken into account. Also, amyloid deposits are frequently observed in the islets. It is unclear whether these changes are genetically mediated or result secondary to the loss of glucose homeostasis. Many studies have looked at some aspect of insulin secretion in NIDDM, and two types of distinct abnormalities have been described. Early on, there is a marked disruption in pulsatile insulin delivery, which is potentially an important contributor to the insulin resistance. It is unclear whether the loss of pulsatile delivery is acquired or genetically induced. Later, after glucose intolerance has started, several other secretory abnormalities develop coincident with loss of beta-cell glucorecognition. The net result is further deterioration in timing of insulin delivery and postprandial hyperglycemia. A second important consequence of the glucose blindness is that the inherent compensatory beta-cell mechanisms that guard against hyperglycemia are bypassed. We propose that the loss of glucose responsiveness is a direct result of an elevated glucose concentration (so-called glucotoxicity) and have generated substantial data in rat models that support this idea. The logical conclusion is that beta-cell function in NIDDM can be maximized by achieving the best metabolic control possible.
New I-type lectins of the CD 33-related siglec subgroup identified through genomics (2002)

Siglecs are sialic-acid-binding proteins of the Ig superfamily that are involved in cell-cell interactions and signalling. In recent years, several novel siglecs that are highly related to CD33/Siglec-2 have been identified through genomics and functional screens. In addition to their distinct sialic-acid-binding properties, most of these novel siglecs bear tyrosine-based signalling motifs that are typically found in inhibitory receptors of the immune system. The restricted expression patterns of CD33-related siglecs in the haemopoietic and immune systems suggests that they are involved in regulating leucocyte activation during inflammatory and immune responses.
Latent feature learning in social media network (2013)

The current trend in social media analysis and application is to use the pre-defined features and devoted to the later model development modules to meet the end tasks. In this work, we claim that representation is critical to the end tasks and contributes much to the model development module. We provide evidence that specially learned feature well addresses the diverse, heterogeneous and collective characteristics of social media data. Therefore, we propose to transfer the focus from the model development to latent feature learning, and present a general feature learning framework based on the popular deep architecture. In particular, following the proposed framework, we design a novel relational generative deep learning model to test the idea on link analysis tasks in the social media networks. We show that the derived latent features well embed both the media content and their observed links, leading to improvement in social media tasks of user recommendation and social image annotation.
From the relaxivity of Gd(DTPA)<sup>2−</sup> to everything else (1991)

We resolve the observed magnetic field-dependent relaxivity of Gd(DTPA)2- into inner and outer sphere contributions by comparison with theory. After noting that the outer sphere part, which contributes comparable to both 1/T1 and 1/T2, is identical to the "susceptibility" effect, we demonstrate the transition from the outer sphere relaxivity of small complexes, e.g., Gd(DTPA)2-, to that of large magnetic particulates, e.g., magnetite, used as T2 agents. This transition is expressed as a shift from a quantum to a classical mechanical description of relaxivity. We next show how to extrapolate the inner sphere contribution of Gd(DTPA)2- to similar small agents with greater structural symmetry, e.g., Gd(NOTA)-, by lengthening the electronic relaxation time and to ternary macromolecular complexes of small agents with protein by lengthening the rotational relaxation time. Finally, we indicate how relatively large lipid vesicles containing either small paramagnetic complexes or magnetized particulates may be considered analogs of Gd(DTPA)2-, with analogous inner and outer sphere contributions.
Clinical Significance of Matrix Metalloproteinase (MMP)-2 in Patients With Acute Heart Failure (2010)

The serum levels of matrix metalloproteinases (MMPs) increase during chronic heart failure (HF) and the MMP-2 are related to a poor prognosis. However, the roles of MMP-2 in acute HF (AHF) remain unclear. We investigated the change and clinical significance of MMP-2 in these conditions. The serum levels of MMP-2 were measured in 83 AHF patients before starting treatment (day 1), 3 (day 3) and 7 (day 7) days after admission, and before discharge (predischarge). MMP-2 decreased rapidly and significantly from day 3 to day 1 (902.9 ± 304.2 versus 1220.4 ± 330.5 ng/mL; P < 0.0001), whereas that of MMP-2 was not significantly different on day 7 and at predischarge (894.7 ± 278.9 and 920.0 ± 269.6 ng/mL, respectively) compared to day 3. We evaluated the relationships between ΔMMPs, defined as the changes in MMPs from day 1 to day 3 and HF events including cardiac death, readmission to hospital for HF, and uncontrollable HF. The MMP-2 value was significantly (P = 0.004) more decreased in the event-free group (381.4 ± 256.5 ng/mL) than in the event group (211.9 ± 225.5 ng/mL) between day 1 and day 3. The results of the multivariate logistic regression model for predicting HF events found that the specific factor for HF events was ΔMMP-2. Cutoff values of ΔMMP-2 were determined and event-free curves were constructed. Kaplan-Meier curves showed that the prognosis was significantly better among the patients with reductions in ΔMMP-2 values of more than 342 ng/mL. The serum levels of MMP-2 decreased with improvements in AHF. Rapid decreases in MMP-2 may be important for a better clinical outcome in patients with AHF.
Timing analysis of worst case with direct NM of OSEK NM (2008)

This paper presents the worst case network situation and the analyzed result for timing test on real embedded system. Timing is critical fact in a specific network. As the needs that vehicle is more intelligence, electrical components of vehicle are more enhanced and complicated. The number of electronic control units (ECUs) which are set up at vehicle is significantly increased. Therefore there is the huge network compounded with a lot of ECUs in automotive system. The more nodes connected and having variable functions, the network has higher probability to occur fault. The fault of network may cause extremely dangerous accident, especially automotive network. There is strong trend that ECU use open systems and their interfaces for the electronics in motor vehicles (OSEK) which is real time OS for automotive system. OSEK has network management tool which is OSEK network management (OSEK NM). Direct NM, which is one of management rule of OSEK NM for a network of ECUs that communicate via a CAN bus is chosen for this paper. The variable time is important factor in real time system. The repairing mechanism of direct NM is analyzed. The main contribution of this paper is to investigate the worst case for the timing of network management with the management mechanism of OSEK NM. For that purpose we tested each case on real embedded system with changing various circumstance variables and the analysis on the time result of the test is proposed.
The actin‐bundling protein L‐plastin supports T‐cell motility and activation (2013)

Tight regulation of actin dynamics is essential for T-cell trafficking and activation. Recent studies in human and murine T cells reveal that T-cell motility and full T-cell activation require the hematopoietic-specific, actin-bundling protein L-plastin (LPL). T cells lacking LPL do not form fully mature synapses and thus demonstrate reduced cytokine production and proliferation. Reduction or loss of LPL expression also reduces the velocity of T cells and impairs thymic egress and intranodal motility. Whereas dispensable for proximal T-cell receptor and chemokine receptor signaling, LPL is critical to the later stages of synapse maturation and cellular polarization. Serine phosphorylation, calcium, and calmodulin binding regulate the bundling activity and localization of LPL following T-cell receptor and chemokine receptor engagement. However, the interaction between these regulatory domains and resulting changes in local control of actin cytoskeletal structures has not been fully elucidated. Circumstantial evidence suggests a function for LPL in either the formation or maintenance of integrin-associated adhesion structures. As LPL may be a target of the commonly used immunosuppressive agent dexamethasone, full elucidation of the regulation and function of LPL in T-cell biology may illuminate new pathways for clinically useful immunotherapeutics.
The Bis(Indolyl)Imidazole Alkaloid Nortopsentin A Exhibits Antiplasmodial Activity (2013)

A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I fluorescence-based assay. Fractions derived from a sponge of the genus Spongosorites exhibited potent inhibition of Plasmodium falciparum growth. This genus of sponge has been reported to contain the nortopsentin and topsentin class of bis-indole imidazole alkaloids. This is the first report of nortopsentin A inhibiting parasite growth at the trophozoite stage at submicromolar 50% inhibitory concentrations (IC(50)).
Antiasthmatic Effects of Onions (1989)

Thiosulfinates are responsible for antiasthmatic and anti-inflammatory properties of onions. We tested the effect of diphenylthiosulfinate on platelet-activating factor (PAF)-induced bronchial hyperreactivity to histamine: According to a randomized crossover protocol, groups of 14 guinea pigs inhaled histamine, were then treated orally with either vehicle or with 10–100 mg/kg diphenylthiosulfinate, inhaled 1 µg PAF, and thereafter the same histamine dose given prior to PAF. In the control group the histamine response increased threefold; in the treated group the histamine response decreased. The effect of 100 mg diphenylthiosulfinate lasted 12 h. Antihistamine effects were not demonstrable in this test system. We conclude that thiosulfinates inhibit PAF-induced hyperreactivity.
A Pantetheinase-Resistant Pantothenamide with Potent, On-Target, and Selective Antiplasmodial Activity (2015)

Pantothenamides inhibit blood-stage Plasmodium falciparum with potencies (50% inhibitory concentration [IC50], ∼20 nM) similar to that of chloroquine. They target processes dependent on pantothenate, a precursor of the essential metabolic cofactor coenzyme A. However, their antiplasmodial activity is reduced due to degradation by serum pantetheinase. Minor modification of the pantothenamide structure led to the identification of α-methyl-N-phenethyl-pantothenamide, a pantothenamide resistant to degradation, with excellent antiplasmodial activity (IC50, 52 ± 6 nM), target specificity, and low toxicity.
Comparative studies of heparin cofactor activity toward antithrombin III and heparin cofactor II, and antithrombin III affinity between low molecular weight heparin and unfractionated heparin. (1990)

The accelerating effects of an UF heparin (Novo) and two LMW heparins (Fragmin and PK 10169) on AT III and HC II were investigated in a purified system. The effects of these heparins on APTTs were examined using human plasma. Fractionation of these heparins by affinity column chromatography yielded the following results: UF heparin was separated into two distinct fractions, LA and HA for AT III. Both LMW heparins were separated into three fractions: NA, LA, and HA for AT III. The accelerating effects of these fractions on both antithrombin and anti-Factor Xa activity of AT III were dependent on the strength of their affinity to AT III. The accelerating effects of these fractions on the antithrombin activity of HC II was independent of the strength of their affinity for AT III. LA had a much stronger anticoagulant activity of HC II toward thrombin than did HA. It is concluded that LA for AT III is necessary to show HC II activity.