gebhart/patrepeval huggingface dataset:
Induction assisted laser-cladding a new and effective method for producing high wear resistant coatings on steel components (1998)

Despite better wear resistance two problems hinder the wide industrial application of laser-cladding: 1) low cladding speeds and deposition rates; and 2) crack formation (within the clad when using heat treatable steels as base material and within brittle hard-facing alloys). To avoid these disadvantages, an additional power source, which is suitable for the laser-cladding process, is needed. The purpose of this additional power source is to reduce the temperature gradient within the clad and base material while cooling and to deliver supplementary inexpensive energy. Induction heating is a smart, easily adjusted and adaptable technique to address this need. The combination of induction preheating followed by laser-cladding, for example, makes it possible to coat high carbon steels (AISI 1043) such as cold work tool steels (AISI O2) with hard, wear resistant alloys (Nicrobor 40, Deloro 60). Although cracks within the clad can be avoided in every case, induction assisted laser-cladding allows the simultaneous generation of martensitic layers within the base material. This opens the possibility for laser-cladding and induction heat treatment in one step. Furthermore the cladding speed and the deposition rate can be increased by ten times over conventional laserbeam-cladding. As a result, production cost can be reduced despite higher technological expenditure. Nevertheless, the typical advantage of laser-cladding (namely, low dilution of base material into the clad material) is maintained.
A New Method for Elevator Group Control System with Advanced Information (2013)

This paper gives a novel method for elevator group control system with advanced information of passengers riding time and their destinations. Recently, untouched sensing technologies have developed, for example, visual sensing with cameras, RFID, and so on. We make clear a problem of relations between transportation capacity and division of passenger groups, and propose the method to solve the problem by applying new values to selecting rules and a value function for decision of an assigned car. We simulated the new system to evaluate the method. A result of the simulation shows that the proposed method can improve performance compared with the conventional one.
BOPSCAN Technology: A methodology and implementation of the billion point optical scanner (1998)

The non-mechanical inertialess optical scanner is a critical building block in numerous optical applications ranging from laser communications, optical storage, and three dimensional (3-D) displays. Perhaps, the ultimate goal of the scanner industry is to realize a low cost 3-D scanner that can rapidly and efficiently scan a volume with 1000 x 1000 x 1000 or a billion points [1]. This also means that such a scanner must have a billion degrees of freedom, a non-trivial task from a device control point of view. In this paper, we describe, perhaps for the first time, a solution to achieving this billion points scanner [2]. Our approach is to use planar active (electronically programmable) and passive thin- film polarization sensitive optics in a compact LEGO-like stacking or cascaded binary switching architecture to form the desired 3-D scanner. We call our approach BOPSCAN Technology: Binary Optical Polarization Sensitive Cascaded Architecture Network Technology. Our non-mechanical optical scanner features include microsecond regime beam reset times, low (e.g., mW levels) control power and low complexity drive electronics, large (several cms) or small (few hundred microns) scan beam active aperture sizes, very large number of scan beams (over a billion), very few control signals (e.g., only 30 signals for a billion point scan), high throughput efficiency (e.g., > 50 %), and most importantly, potential for low cost.
Implantable Flexible-Coiled Wireless Intraocular Pressure Sensor (2009)

This work presents an implantable wireless passive pressure sensor for long-range continuous intraocular pressure (IOP) monitoring of glaucoma patients. The sensor is microfabricated with use of parylene C (poly-chloro-p-xylylene) to create a flexible coil substrate that can be folded during implantation for suture-less minimally invasive surgery, while stretched back without damage for enhanced inductive sensor-reader coil coupling and the corresponding sensing signal. Extensive device characterizations including on-bench testing and in vivo and ex vivo animal studies verify the device feasibility in both engineering (1 mmHg pressure sensing accuracy and 2 cm sensing distance) and surgical (robust fixation to the iris and long-term biocompatibility in the intraocular environment) aspects, all meeting specifications for future practical implementation of such IOP sensing technology.
Liquid crystal polymer vector vortex waveplates with sub-micrometer singularity (2015)

Small singularity size is critical for achieving low light loss and high contrast for vector vortex waveplate (VVW) based coronagraph. In the opto-mechanical system for recording VVW with photoalignment, reshaping the center light intensity distribution and precision alignment can effectively decrease singularity size. We have developed methods for redistributing the light intensity near the singularity. A new direct alignment method is introduced. This method helps in reaching the optimized alignment position by allowing to depict the beam profile at the photoalignment surface. Employing these techniques and new liquid crystal polymer materials, we have fabricated VVWs with sub-micrometer defect size for UV, and subs-wavelength defect size for 1.5 micrometer wavelength range. Inversely twisted layers method was used for fabrication of broadband VVW for the near infrared region.
The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs (1998)

The nonsense-mediated mRNA decay pathway is an example of an evolutionarily conserved surveillance pathway that rids the cell of transcripts that contain nonsense mutations. The product of the UPF1 gene is a necessary component of the putative surveillance complex that recognizes and degrades aberrant mRNAs. Recent results indicate that the Upf1p also enhances translation termination at a nonsense codon. The results presented here demonstrate that the yeast and human forms of the Upf1p interact with both eukaryotic translation termination factors eRF1 and eRF3. Consistent with Upf1p interacting with the eRFs, the Upf1p is found in the prion-like aggregates that contain eRF1 and eRF3 observed in yeast [PSI+] strains. These results suggest that interaction of the Upf1p with the peptidyl release factors may be a key event in the assembly of the putative surveillance complex that enhances translation termination, monitors whether termination has occurred prematurely, and promotes degradation of aberrant transcripts.
A convenient synthesis of 9<i>H</i>‐dibenz[<i>c,f</i>]imidazo[1,2‐<i>a</i>]azepin‐9‐ones (1981)

Abstract A convenient three step synthesis of 9 H ‐dibenz[ c,f ]imidazo[1,2‐ a ]azepin‐9‐ones from readily available 2‐phenylimidazoline and a methyl benzoate is described.
New Highly Sensitive Real-Time PCR Assay for HIV-2 Group A and Group B DNA Quantification (2017)

HIV-2 infection is characterized by a very low replication rate in most cases and low progression. This necessitates an approach to patient monitoring that differs from that for HIV-1 infection. Here, a new highly specific and sensitive method for HIV-2 DNA quantification was developed. The new test is based on quantitative real-time PCR targeting the long terminal repeat (LTR) and <i>gag</i> regions and using an internal control. Analytical performance was determined in three laboratories, and clinical performance was determined on blood samples from 63 patients infected with HIV-2 group A (<i>n</i> = 35) or group B (<i>n</i> = 28). The specificity was 100%. The 95% limit of detection was three copies/PCR and the limit of quantification was six copies/PCR. The within-run coefficients of variation were between 1.03% at 3.78 log<sub>10</sub> copies/PCR and 27.02% at 0.78 log<sub>10</sub> copies/PCR. The between-run coefficient of variation was 5.10%. Both manual and automated nucleic acid extraction methods were validated. HIV-2 DNA loads were detectable in blood cells from all 63 patients. When HIV-2 DNA was quantifiable, median loads were significantly higher in antiretroviral-treated than in naive patients and were similar for groups A and B. HIV-2 DNA load was correlated with HIV-2 RNA load (<i>r</i> = 0.68; 95% confidence interval [CI], 0.4 to 0.8; <i>P</i> < 0.0001). Our data show that this new assay is highly sensitive and quantifies the two main HIV-2 groups, making it useful for the diagnosis of HIV-2 infection and for pathogenesis studies on HIV-2 reservoirs.
High-power VCSEL arrays with customized beam divergence for 3D-sensing applications (2019)

The demand for high-power vertical-cavity surface-emitting laser (VCSEL) arrays is increasing continuously due to the growing market for 3D sensing solutions. In these applications (e.g. face recognition or drive-assistance systems), the distances of the objects of interest vary by orders of magnitude. For this reason, a flexible tailoring of the beam divergence is desired. In this work, we discuss methods to tune the emitted beam profile by only optimizing the epitaxial structure of a VCSEL. We show results of VCSEL arrays with beam divergences ranging between ~10° and 45°. This technique is also power scalable and multi-watt VCSEL arrays can be realized.
Linear encoding device (1993)

A Linear Motion Encoding device for measuring the linear motion of a moving object is disclosed in which a light source is mounted on the moving object and a position sensitive detector such as an array photodetector is mounted on a nearby stationary object. The light source emits a light beam directed towards the array photodetector such that a light spot is created on the array. An analog-to-digital converter, connected to the array photodetector is used for reading the position of the spot on the array photodetector. A microprocessor and memory is connected to the analog-to-digital converter to hold and manipulate data provided by the analog-to-digital converter on the position of the spot and to compute the linear displacement of the moving object based upon the data from the analog-to-digital converter.
Kinematic calibration on a parallel kinematic machine tool of the Stewart platform by circular tests (2004)

This work presents a methodology to calibrate kinematic parameters on a hexapod-type parallel kinematic machine tool of the Stewart platform. Unlike in the case of conventional serial kinematic feed drives, on parallel kinematic feed drives the tool position and orientation can be only indirectly estimated from angular position of servo motors. Therefore, for high-accuracy motion control of parallel kinematic feed drives, it is the most critical issue to calibrate kinematic parameters such as the reference length of struts and the location of base joints. This paper demonstrates a calibration method based on circular tests to measure the machine's contouring accuracy in a circular operation. To optimize the positioning accuracy of a parallel kinematic feed drive over the entire workspace, it is important to evaluate the machine's global positioning error in circular tests by using the specialized jig plate. The effectiveness of the calibration is experimentally validated on a commercial parallel kinematic machining center.
SSP: Single Shot Future Trajectory Prediction (2020)

We propose a robust solution to future trajectory forecast, which can be practically applicable to autonomous agents in highly crowded environments. For this, three aspects are particularly addressed in this paper. First, we use composite fields to predict future locations of all road agents in a singleshot, which results in a constant time complexity, regardless of the number of agents in the scene. Second, interactions between agents are modeled as a non-local response, enabling spatial relationships between different locations to be captured temporally as well (i.e., in spatio-temporal interactions). Third, the semantic context of the scene are modeled and take into account the environmental constraints that potentially influence the future motion. To this end, we validate the robustness of the proposed approach using the ETH, UCY, and SDD datasets and highlight its practical functionality compared to the current state-of-the-art methods.
Development of rhodium metalloinsertors as chemotherapeutic agents (2015)

Deficiencies in the mismatch repair (MMR) pathway have been assocd. with various cancers, and many commonly used\nchemotherapeutics have decreased effectiveness against MMR- deficient cancers. Rhodium metalloinsertors are octahedral\ncomplexes that bind DNA mismatches with high affinity and specificity through metalloinsertion, a binding mode through which\nthe compds. insert into the DNA duplex from the minor groove and eject the mismatched bases. These compds. also exhibit\nunique cell- selective cytotoxicity, preferentially inducing necrosis in mismatch repair (MMR) - deficient cells over MMR- proficient\ncells. This chemotherapeutic activity, which has been confirmed across multiple assays and in different systems for\ncomparing MMR deficiency to proficiency, has been found to be the result of specific targeting of the metalloinsertors to\nnuclear DNA mismatches. Most recently, a new generation of metalloinsertors with enhanced potency and selectivity has\nbeen discovered which display Rh- O coordination and a possible different binding disposition in the mismatch site as compared\nto earlier generation metalloinsertors.
An efficient timer-based hard handoff algorithm for cellular networks (2004)

We introduce a new hard handoff algorithm that employs local averaging, a drop timer, and hysteresis. The proposed algorithm achieves better performance than conventional hysteresis-based handoff algorithms that employ exponential averaging, particularly in microcellular environments. We develop an analytical model and an efficient numerical procedure to evaluate accurately the performance and evaluation technique greatly simplify the practical task of dimensioning the cellular network for optimum performance.
Metal Induced Continuous Grain Polycrystalline Silicon Thin Film Transistors and Its Application for Field Sequential Color-Liquid Crystal Display (FSC-LCD) (2009)

Metal induced polycrystalline silicon (poly-Si) films composing of continuous zonal domain (CZD) have been obtained through pre-defined crystalline nucleation lines. The crystallization process is precisely controllable and the annealing time can be shorter than one hour. P-channel thin film transistors (TFTs) built on CZD poly-Si present high performance and high uniformity. In this paper, we also demonstrate the application of CZD TFT to fast addressing active matrix field sequential color-liquid crystal display (FSC-LCD). A prototype display panel has been fabricated. Large aperture ratio, excellent color purity and fast moving image can be obtained.
Characterization of the Antiapoptotic Bcl-2 Family Member Myeloid Cell Leukemia-1 (Mcl-1) and the Stimulation of Its Message by Gonadotropins in the Rat Ovary1 (1999)

The majority of ovarian follicles undergo atresia mediated by apoptosis. Bcl-2-related proteins act as regulators of apoptosis via the formation of dimers with proteins inside and outside the Bcl-2 family. Previous studies have identified BAD as a proapoptotic Bcl-2 family member expressed in the ovary. It is known that BAD phosphorylation induced by survival factors leads to its preferential binding to 14-3-3 and suppression of the death-inducing function of BAD. To identify ovarian binding partners for hypophosphorylated BAD, we performed a yeast two-hybrid screening of a rat ovary complementary DNA library using as bait a mutant BAD incapable of binding to 14-3-3. Screening of yeast transformants yielded positive clones encoding the rat ortholog of Mcl-1 (myeloid cell leukemia-1), an antiapoptotic Bcl-2 protein. Amino acid sequence analysis revealed that rat and human Mcl-1 showed a complete conservation of the Bcl-2 homology domains BH1, BH2, and BH3. In the yeast two-hybrid system, Mcl-1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic (Bax, Bak, Bok, Bik, and BOD) compared with antiapoptotic Bcl-2 family members (Bcl-2, Bcl-xL, Bcl-w, Bfl-1, CED-9, and BHRF-1). Northern blot hybridization demonstrated expression of Mcl-1 transcripts of 2.3 and 3.7 kb in the ovary and diverse other rat tissues. In immature rats, PMSG treatment led to a transient increase in the 2.3-kb Mcl-1 transcript, peaking at 6 h after injection and returning to baseline levels after 24 h. Moreover, the same transcript was induced in the PMSG-primed preovulatory rat ovary 6 h after the administration of ovulatory doses of either hCG or FSH. In situ hybridization studies revealed that the gonadotropin stimulation of ovarian Mcl-1 message occurs in both granulosa and thecal cells. In conclusion, rat Mcl-1 was identified as an ovarian BAD-interacting protein and the message for the antiapoptotic Mcl-1 protein was induced after treatment with gonadotropins in granulosa and thecal cells of growing follicles.
Cell-Free Protein Synthesis Systems with Extracts from Cultured Human Cells (2009)

Cell-free protein synthesis systems have been established with extracts from cultured human cells, HeLa, and hybridoma cells. The former cell line is used to prepare extracts for robust translation, whereas the extract from the latter is primarily employed for expression of glycoproteins. Productivity of both systems can be enhanced by addition of K3L and GADD34, factors that diminish phosphorylation of eIF2alpha. The coupled transcription/translation system is also available as a convenient tool, particularly for the production of large recombinant proteins.
A fully integrated broadband direct-conversion receiver for DBS applications (2002)

The key obstacle to successful integration of broadband receivers is that the wide-tuning range (C/sub H//C/sub L/>5) varactors required are not available in a standard process. In addition, when external hyper-abrupt varactors are used, a separate high-voltage supply (e.g. 30 V) is required to cover the entire frequency band. More recently, integrated wideband tuners have been reported using multiple wideband RC oscillators, but they require a complicated multi-loop architecture to achieve desired phase-noise performance. Using multiple integrated LC voltage-controlled oscillators (VCO) (including resonators) a fully-integrated single-loop frequency synthesizer is possible which allows the development of a single-chip solution for broadband applications. This results in a significant cost reduction and ease of system-board design.
Machine Learning to Quantitate Neutrophil NETosis (2019)

We introduce machine learning (ML) to perform classification and quantitation of images of nuclei from human blood neutrophils. Here we assessed the use of convolutional neural networks (CNNs) using free, open source software to accurately quantitate neutrophil NETosis, a recently discovered process involved in multiple human diseases. CNNs achieved >94% in performance accuracy in differentiating NETotic from non-NETotic cells and vastly facilitated dose-response analysis and screening of the NETotic response in neutrophils from patients. Using only features learned from nuclear morphology, CNNs can distinguish between NETosis and necrosis and between distinct NETosis signaling pathways, making them a precise tool for NETosis detection. Furthermore, by using CNNs and tools to determine object dispersion, we uncovered differences in NETotic nuclei clustering between major NETosis pathways that is useful in understanding NETosis signaling events. Our study also shows that neutrophils from patients with sickle cell disease were unresponsive to one of two major NETosis pathways. Thus, we demonstrate the design, performance, and implementation of ML tools for rapid quantitative and qualitative cell analysis in basic science.
Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. II. Structure determination of probestin. (1990)

Probestin, a new inhibitor of aminopeptidase M, has been isolated from the culture broth of Streptomyces azureus MH663-2F6. The 1H and 13C NMR studies and amino acid analysis confirmed the presence of one 3-amino-2-hydroxy-phenylbutanoic acid, leucine and two proline residues in the molecule. Stereochemistries of these amino acids were determined by HPLC analysis. The fragmentation pattern shown in the mass spectrum and the chemical analysis on probestin clarified the amino acid sequence. Thus the structure of probestin was defined as (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-leucyl-L-prolyl-L-pro line.
Programmed Assembly of Host–Guest Protein Crystals (2016)

The binding and release of guest fluorescent proteins inside a protein crystal with 13 nm axial pores is controlled. Spatially segregated guest protein loading is achieved via sequential binding and release stages. Additionally, selective stabilization of the crystal exterior results in hollow crystalline shells.
Caller identification for the SCANMail voicemail browser (2001)

SCANMail is a prototype system developed at AT&T Labs for the purpose of providing useful tools for managing and searching through voicemail messages. Content is extracted from voicemail messages using various speech and text processing tools. One such content category is the identity of the message caller. This paper describes CallerID, the server tool attached to SCANMail for the purpose of providing caller labels for voicemail messages. CallerID makes use of text independent speaker recognition techniques. Two kinds of requests are handled by the CallerID server. A request triggered by the arrival of a new voicemail message results in the processing of the message to score it against the models of callers assigned to the user (recipient) in order to propose the identity of the caller. A second request is initiated by a user who provides a caller label for a message he/she has reviewed. CallerID processes the message and uses it to train or adapt a speaker model for the caller whose label is provided. The paper describes in detail the CallerID functions and provides some results of performance evaluations of the caller identification capability.
An efficient dataflow execution method for mobile context monitoring applications (2012)

In this paper, we propose a novel efficient dataflow execution method for mobile context monitoring applications. As a key approach to minimize the execution overhead, we propose a new dataflow execution model, producer-oriented model. Compared to the conventional consumer-oriented model adopted in stream processing engines, our model significantly reduces execution overhead to process context monitoring dataflow reflecting unique characteristics of context monitoring. To realize the model, we develop DataBank, an execution container that takes charge of the management and delivery of the output data for the associated operator. We demonstrate the effectiveness of DataBank by implementing three useful applications and their dataflow graphs, i.e., MusicMap, FindMyPhone, and CalorieMonitor. Using the applications, we show that DataBank reduces the CPU utilization by more than 50%, compared to the methods based on the consumer-oriented model; DataBank enables more context monitoring applications to run concurrently.