gebhart/patrepeval huggingface dataset:
Polyphenol-rich <i>Avicennia marina</i> leaf extracts induce apoptosis in human breast and liver cancer cells and in a nude mouse xenograft model (2016)

Avicennia marina is the most abundant and common mangrove species and has been used as a traditional medicine for skin diseases, rheumatism, ulcers, and smallpox. However, its anticancer activities and polyphenol contents remain poorly characterized. Thus, here we investigated anticancer activities of secondary A. marina metabolites that were purified by sequential soxhlet extraction in water, ethanol, methanol, and ethyl acetate (EtOAc). Experiments were performed in three human breast cancer cell lines (AU565, MDA-MB-231, and BT483), two human liver cancer cell lines (HepG2 and Huh7), and one normal cell line (NIH3T3). The chemotherapeutic potential of A. marina extracts was evaluated in a xenograft mouse model. The present data show that EtOAc extracts of A. marina leaves have the highest phenolic and flavonoid contents and anticancer activities and, following column chromatography, the EtOAc fractions F2-5, F3-2-9, and F3-2-10 showed higher cytotoxic effects than the other fractions. 1H-NMR and 13C-NMR profiles indicated that the F3-2-10 fraction contained avicennones D and E. EtOAc extracts of A. marina leaves also suppressed xenograft MDA-MB-231 tumor growth in nude mice, suggesting that EtOAc extracts of A. marina leaves may provide a useful treatment for breast cancer.
Video analysis validation of a real-time physical activity detection algorithm based on a single waist mounted tri-axial accelerometer sensor (2016)

We have validated a real-time activity classification algorithm based on monitoring by a body worn system which is potentially suitable for low-power applications on a relatively computationally lightweight processing unit. The algorithm output was validated using annotation data generated from video recordings of 20 elderly volunteers performing both a semi-structured protocol and a free-living protocol. The algorithm correctly identified sitting 75.1% of the time, standing 68.8% of the time, lying 50.9% of the time, and walking and other upright locomotion 82.7% of the time. This is one of the most detailed validations of a body worn sensor algorithm to date and offers an insight into the challenges of developing a real-time physical activity classification algorithm for a tri-axial accelerometer based sensor worn at the waist.
Viable but nonrecoverable stage of <i>Salmonella enteritidis</i> in aquatic systems (1984)

An environmental isolate (13- 1BB ) of Salmonella enteritidis serogroup C1 was inoculated into sterile Potomac River water microcosms to observe survival and culturability of the organism by employing acridine orange direct count, fluorescent antibody direct count, direct viable count, plate count on veal infusion agar and xylose lysine decarboxylase agar, and indirect enumeration by the most-probable-number method (MPN), using media selective for Salmonella. Loss of culturability on laboratory media was observed within 48 h. However, cultures could be "resuscitated" and cultured on solid media, following addition of nutrients to the microcosms . Cells, resuscitated 4 days after apparent "die-off" (0 colony-forming units (cfu)/mL) using plate count techniques, yielded numbers of cfu in the same order of magnitude as had been observed before the onset of nutrient limitation. Microscopic techniques for direct viable counting indicated that viability is maintained for as long as 60 days after depletion of nutrients, although attempts to culture these cells, by addition of nutrient, after 21 days yielded apparently sterile plates. Thus, longer periods of "dormancy" appear to require conditions other than simple nutrient addition for resumption of cell growth and division.
The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate (2008)

Mef2c is a MADS (MCM1-agamous-deficient serum response factor) transcription factor best known for its role in muscle and cardiovascular development. A causal role of up-regulated MEF2C expression in myelomonocytic acute myeloid leukemia (AML) has recently been demonstrated. Due to the pronounced monocytic component observed in Mef2c-induced AML, this study was designed to assess the importance of Mef2c in normal myeloid differentiation. Analysis of bone marrow (BM) cells manipulated to constitutively express Mef2c demonstrated increased monopoiesis at the expense of granulopoiesis, whereas BM isolated from Mef2c(Delta/-) mice showed reduced levels of monocytic differentiation in response to cytokines. Mechanistic studies showed that loss of Mef2c expression correlated with reduced levels of transcripts encoding c-Jun, but not PU.1, C/EBPalpha, or JunB transcription factors. Inhibiting Jun expression by short-interfering RNA impaired Mef2c-mediated inhibition of granulocyte development. Moreover, retroviral expression of c-Jun in BM cells promoted monocytic differentiation. The ability of Mef2c to modulate cell-fate decisions between monocyte and granulocyte differentiation, coupled with its functional sensitivity to extracellular stimuli, demonstrate an important role in immunity--and, consistent with findings of other myeloid transcription factors, a target of oncogenic lesions in AML.
Dobesilate is an angiogenesis inhibitor. (2005)

Aberrant angiogenesis is essential for the progression of solid tumors and hematological malignancies. Antiangiogenic therapy is one of the most promising approaches to treat such diseases. Dobesilate is an oral agent for treatment of vascular complications of diabetic retinopathy. We have examined the possibility that this compound could interfere with the process of angiogenesis in a mouse gelatine sponge assay using acidic fibroblast growth factor (aFGF) as an inducer of neovascularization. According to the results reported here, dobesilate remarkably reduced vessel ingrowth in aFGF-containing subcutaneous sponges in mice. These findings suggest that dobesilate could be an effective agent in the treatment of angiogenesis-dependent diseases involving FGFs.
Design and Evaluation of a Secure Virtual Power Plant. (2017)

For three years, Sandia National Laboratories, Georgia Institute of Technology, and University of Illinois at Urbana-Champaign investigated a smart grid vision in which renewable-centric Virtual Power Plants (VPPs) provided ancillary services with interoperable distributed energy resources (DER). This team researched, designed, built, and evaluated real-time VPP designs incorporating DER forecasting, stochastic optimization, controls, and cyber security to construct a system capable of delivering reliable ancillary services, which have been traditionally provided by large power plants or other dedicated equipment. VPPs have become possible through an evolving landscape of state and national interconnection standards, which now require DER to include grid-support functionality and communications capabilities. This makes it possible for third party aggregators to provide a range of critical grid services such as voltage regulation, frequency regulation, and contingency reserves to grid operators. This paradigm (a) enables renewable energy, demand response, and energy storage to participate in grid operations and provide grid services, (b) improves grid reliability by providing additional operating reserves for utilities, independent system operators (ISOs), and regional transmission organization (RTOs), and (c) removes renewable energy high-penetration barriers by providing services with photovoltaics and wind resources that traditionally were the jobs of thermal generators. Therefore, it is believed VPP deployment will have far-reaching positive consequences for grid operations and may provide a robust pathway to high penetrations of renewables on US power systems. In this report, we design VPPs to provide a range of grid-support services and demonstrate one VPP which simultaneously provides bulk-system energy and ancillary reserves.
Sex Steroids in the Umbilical Circulation of Fetal Rhesus Monkeys from the Time of Gonadal Differentiation* (1980)

Male rhesus monkey fetuses have significantly more testosterone (T) in their circulation than females on days 35--50 of gestation (P less than 0.01; n = 6 males and 6 females). However, we found no sex differences for androstenedione (delta 4). T concentrations remained significantly higher in male fetuses than in females later in gestation, e.g. days 79--84, 100--133, and 140--160. Levels of delta 4 differed between the sexes only on days 79--84, and dihydrotestosterone concentrations were significantly higher in male fetuses than in females on days 100--133 and 140--163. The fact that delta 4 concentrations were not different between the sexes at the earliest period studied (days 35--50) indicates that systemic concentrations of this hormone in the fetus probably are not important for sexual differentiation, especially of the central nervous system. Quantification of three steroids (T, delta 4, and dihydrotestosterone) in umbilical arterial and venous plasma from five male and nine female fetuses (days 35--100) revealed significant arterial/venous differences only for T in males (arterial greater than venous). These data, which suggest that fetal testes secrete T during morphological differentiation, lend credence to the hypothesis that endogenous T partially regulates sexual differentiation.
Waveform design for FMCW MIMO radar based on frequency division (2013)

Classical radar systems can achieve the angular resolution based on linear phased array antenna technology. If a high angular resolution is required a large antenna aperture is needed. In case of a single transmitter (TX) the number N of receive antenna elements corresponds directly to the number of targets that may be separated and resolved by their different azimuth angle positions. The spacing between two adjacent receive antenna elements inside a uniform array determines the maximum unambiguous azimuth observation area. Therefore the antenna aperture is defined by the required angular resolution and the maximum unambiguous azimuth observation area. However, the angular resolution of a radar system can be increased dramatically by using multiple transmit antennas. Each transmitter generates an individual signal that can be clearly distinguished inside the different radar receivers (RX). This Multiple Input Multiple Output (MIMO) technology shifts some of the computation complexity from the receive antenna array into the transmitter side. For the special case of two transmit antennas and an arbitrary number of receive antenna elements a Frequency Modulated Continuous Wave (FMCW) signal is proposed in this paper. In this case the angular resolution of the radar system is improved by the factor of two compared to the same configuration with a single transmit antenna. © 2013 German Inst of Navigation.
Low-viscosity Gear Oil Technology to Improve Wear at Tapered Roller Bearings in Differential Gear Unit (2016)

<div class="section abstract"><div class="htmlview paragraph">Torque loss reduction at differential gear unit is important to improve the fuel economy of automobiles. One effective way is to decrease the viscosity of lubricants as it results in less churning loss. However, this option creates a higher potential for thin oil films, which could damage the mechanical parts. At tapered roller bearings, in particular, wear at the large end face of rollers and its counterpart, known as bearing bottom wear is one of major failure modes. To understand the wear mechanism, wear at the rolling contact surface of rollers and its counterpart, known as bearing side wear, was also observed to confirm the wear impact on the tapered roller bearings. Because gear oils are also required to avoid seizure under extreme pressure, the combination of a phosphorus anti-wear agent and a sulfurous extreme pressure agent are formulated. Because the latter could cause an antagonistic impact on the former, we focused on control of active sulfur content as well as the treat ratios to reduce wear at the tapered roller bearing while maintaining anti-seizure. Additive screening bench tests were performed considering operational conditions in actual gear unit-stand tests on the basis of the above-mentioned concept and the best formulation was identified as a breakthrough for low-viscosity gear oil. This low-viscosity gear oil technology was validated in the unit-stand tests. The sample oil based on the technology demonstrated equivalent performance for anti-wear while maintaining good anti-seizure, to the high-viscosity gear oil.</div></div>
Injuries of the inferior tibiofibular joint (2001)

The following abstracts were originally published in Der Unfallchirurg and are being made available to readers of Journal of Orthopaedic Trauma through an exchange agreement with the Deutsche Gesellschaft für Unfallchirurgie (German Trauma Association).
Asymmetric Cyclization of Propylene Chlorohydrins Catalyzed by an Optically Active Cobalt(salen) Type Complex (1979)

Abstract By using an optically active cobalt complex, N,N′-disalicylidene-(1R,2R)-1,2-cyclohexanediaminatocobalt(II), as a catalyst, optically active methyloxirane was synthesized by the asymmetric elimination of hydrogen chloride with a base from racemic propylene chlorohydrins. The highest optical purity of methyloxirane so far obtained was 35%, observed when 2-chloro-1-propanol and potassium carbonate were used as substrate and base, respectively. The optical rotations of the products and of the unchanged substrates indicate that (S)-1-chloro-2-propanol reacted selectively to produce (S)-methyloxirane, whereas in the case of 2-chloro-1-propanol, the (R)-isomer was preferentially cyclized to give (S)-methyloxirane with inversion of the asymmetric carbon. The physicochemical data of the circular dichroism and absorption spectra indicated a complexation of the optically active cobalt(II) species with potassium carbonate, either the (R)- or (S)-substrate interacting selectively with the Co*/K2CO3complex formed, followed by cyclization of the substrate.
On-chip coils with integrated cores for remote inductive powering of integrated microsystems (2002)

This paper reports on integrated receiver coils and accompanying circuitry for wireless powering of integrated microsystems, emphasizing implantable biomedical applications. These planar spiral coils consist of an electroplated Cu winding and electroplated NiFe core, and they can be post processed directly on top of integrated circuitry. Ten turn, 20 mm/sup 2/ versions of these coils operating at 4 MHz have a Q of 6.6, and can supply loads of a few k/spl Omega/ with over 15 mW of DC power transmitted a distance of 3 cm. A receiver chip optimized to work with these coils has been fabricated and tested. Together with a coil, this circuit can supply over 3 mA DC at 4 V to an integrated microsystem. It also demodulates 50 kbps of ASK encoded data, and generates a 1 MHz system clock.
Simultaneous Visualization of Preoperative Planning Models and Intraoperative 2D Ultrasound for Liver Surgery (2007)

This paper introduces new techniques for simultaneous visualization of preoperative planning models and intraoperative 2D ultrasound for open liver surgery. The driving motivation for our work is to improve the visual presentation of a moving ultrasound plane within a complex, interweaving three-dimensional model of hepatic vascular structures. Major drawbacks of existing systems are occlusions of the ultrasound plane by the planning model and fade-out of crucial context information. Our system allows the surgeon to focus on the ultrasound image while perceiving context-relevant planning information without discarding important morphological information and depth cues. The contribution of this paper is a GPU-accelerated rendering pipeline including new illustrative visualization algorithms for focus & context rendering, distance and intersection accentuation, as well as a hybrid technique for high quality silhouette and hatching stroke generation.
alpha-Naphthyl phosphate: the preferred substrate for acid phosphatase. (1984)

Journal Article alpha-Naphthyl phosphate: the preferred substrate for acid phosphatase. Get access A L Babson A L Babson Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 30, Issue 8, 1 August 1984, Pages 1418–1419, https://doi.org/10.1093/clinchem/30.8.1418 Published: 01 August 1984
Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia (2017)

These findings indicate that camels are a significant reservoir for the maintenance of MERS-CoVs, and they are an important source of human infection with MERS.
Construction and Modelling of an Inducible Positive Feedback Loop Stably Integrated in a Mammalian Cell-Line (2011)

Understanding the relationship between topology and dynamics of transcriptional regulatory networks in mammalian cells is essential to elucidate the biology of complex regulatory and signaling pathways. Here, we characterised, via a synthetic biology approach, a transcriptional positive feedback loop (PFL) by generating a clonal population of mammalian cells (CHO) carrying a stable integration of the construct. The PFL network consists of the Tetracycline-controlled transactivator (tTA), whose expression is regulated by a tTA responsive promoter (CMV-TET), thus giving rise to a positive feedback. The same CMV-TET promoter drives also the expression of a destabilised yellow fluorescent protein (d2EYFP), thus the dynamic behaviour can be followed by time-lapse microscopy. The PFL network was compared to an engineered version of the network lacking the positive feedback loop (NOPFL), by expressing the tTA mRNA from a constitutive promoter. Doxycycline was used to repress tTA activation (switch off), and the resulting changes in fluorescence intensity for both the PFL and NOPFL networks were followed for up to 43 h. We observed a striking difference in the dynamics of the PFL and NOPFL networks. Using non-linear dynamical models, able to recapitulate experimental observations, we demonstrated a link between network topology and network dynamics. Namely, transcriptional positive autoregulation can significantly slow down the "switch off" times, as compared to the non-autoregulated system. Doxycycline concentration can modulate the response times of the PFL, whereas the NOPFL always switches off with the same dynamics. Moreover, the PFL can exhibit bistability for a range of Doxycycline concentrations. Since the PFL motif is often found in naturally occurring transcriptional and signaling pathways, we believe our work can be instrumental to characterise their behaviour.
Atrial Fibrillation (2001)

Electrocardiographically, atrial fibrillation is characterized by the presence of rapid, irregular, fibrillatory waves that vary in size, shape, and timing. This set of findings is usually associated with an irregular ventricular response, although regularization may occur in patients with complete heart block, an accelerated junctional or idioventricular rhythm, or a ventricular paced rhythm. In the past decade, we have gained a greater understanding of atrial fibrillation. Experimental studies have explored the mechanisms of the onset and maintenance of the arrhythmia; drugs have been tailored to specific cardiac ion channels; nonpharmacologic therapies have been introduced that are designed to control or . . .
NMR‐based evaluation of the metabolic profile and response to dichloroacetate of human prostate cancer cells (2014)

The aim of this study was to evaluate the metabolic profile of human prostate cancer cells that have different metastatic potential and to determine their response to dichloroacetate (DCA) using NMR technology. Two isogenic human prostate cancer cell lines, differing in their metastatic potential [LNCaP (poorly metastatic) and LNCaP-LN3 (highly metastatic)], were studied. Metabolite ratios from NMR spectral integrals acquired at a field strength of 9.4 T using a 5-mm broadband probe with an NMR-compatible bioreactor were compared in the presence and absence of the pyruvate dehydrogenase kinase inhibitor DCA. Lactate dehydrogenase (LDH) isoenzymes were assessed by zymography. Following the treatment of cells with 50 mm DCA, there was a significant reduction in the lactate/choline, lactate/creatine, lactate/alanine and the combined lactate/(choline + creatine + alanine) ratios in LNCaP-LN3 cells relative to LNCaP cells. No significant changes in metabolite ratios were found in LNCaP cells following DCA treatment. As expected, LDH zymography assays showed an absence of the LDH-B subunit in LNCaP-LN3 cells, whereas both LDH-A and LDH-B subunits were present in LNCaP cells. DCA was shown to significantly modify the metabolite ratios in highly metastatic LNCaP-LN3 cells, but not in poorly metastatic LNCaP cells. This effect was probably related to the absence of the LDH-B subunit in LNCaP-LN3 cells, and could have a bearing on cancer treatment with DCA and related compounds.
[Impedance testing of compact bone tissue in hypokinetic rats]. (2005)

The bioelectrical impedance method was used for determination of compact bone status in white rats after 28th days of strong hypokinesia. It was shown that the lowering of mechanical loading leads to disturbances in dielectric properties and changes in electrical impedance parameters. These disturbances had different direction and manifestation. It was distinguished the two typical variants of bone dielectric properties changes. The first variant was more characteristic for early stages of hypokinetic osteodestruction, the second variant was more characteristic for the fully development hypokinetic disturbances. It was determine a correlation between the changes in electrical impedance parameters and mane components of bone matrix. The results of this study show that hyperhydratation of bone tissue play important role in hypokinetic changes of bone dielectric properties. Electroimpedance method may be used for early diagnostic of bone state in clinic and experiments.
The eye of the typer (2018)

We examine the relationship between eye gaze and typing, focusing on the differences between touch and non-touch typists. To enable typing-based research, we created a 51-participant benchmark dataset for user input across multiple tasks, including user input data, screen recordings, webcam video of the participant's face, and eye tracking positions. There are patterns of eye movements that differ between the two types of typists, representing glances at the keyboard, which can be used to identify touch-.typed strokes with 92% accuracy. Then, we relate eye gaze with cursor activity, aligning both pointing and typing to eye gaze. One demonstrative application of the work is in extending WebGazer, a real-time web-browser-based webcam eye tracker. We show that incorporating typing behavior as a secondary signal improves eye tracking accuracy by 16% for touch typists, and 8% for non-touch typists.