gebhart/patrepeval huggingface dataset:
Nonlinear Light Scattering and Spectroscopy of Particles and Droplets in Liquids (2012)

Nano- and microparticles have optical, structural, and chemical properties that differ from both their building blocks and the bulk materials themselves. These different physical and chemical properties are induced by the high surface-to-volume ratio. As a logical consequence, to understand the properties of nano- and microparticles, it is of fundamental importance to characterize the particle surfaces and their interactions with the surrounding medium. Recent developments of nonlinear light scattering techniques have resulted in a deeper insight of the underlying light-matter interactions. They have shed new light on the molecular mechanism of surface kinetics in solution, properties of interfacial water in contact with hydrophilic and hydrophobic particles and droplets, molecular orientation distribution of molecules at particle surfaces in solution, interfacial structure of surfactants at droplet interfaces, acid-base chemistry on particles in solution, and vesicle structure and transport properties.
Estimation of Donor Usability for Islet Transplantation in the United States with the Kyoto Islet Isolation Method (2009)

The quality of donor pancreata is important for successful islet isolation. However, in some countries like Japan, the number of donor pancreata is very low; therefore, marginal donors have been used with less restrictive donor criteria. In order to use marginal donor pancreata, we established the Kyoto islet isolation method (KIIM). According to United Network for Organ Sharing (UNOS) in 2005, more than 6,000 pancreata were not clinically used in the US. In this study, we applied the KIIM for brain-dead donors and reevaluated donor usability based on the Japanese islet donor criteria. Islets were isolated with the Ricordi method using pancreata stored in University of Wisconsin (UW) solution (UW group) or by the two-layer method (TLM group) or the TLM combined with ductal injection (DI group). We implemented the KIIM (KIIM group) to confirm the effect of the KIIM on brain-dead donors. Donor charts in Texas from 2005 to 2006 were reviewed. If pancreata were not used clinically, the reason was reviewed and donors were reevaluated based on Japanese criteria. There were no significant differences of islet yield, viability, and purity between the UW and TLM groups. The DI group significantly improved islet yields and isolations were further improved in the KIIM group [UW: 251,663 +/- 60,217 islet equivalent (IE); TLM: 243,738 +/- 54,170 IE; DI: 498,639 +/- 28,853 IE; KIIM: 678,286 +/- 55,853]. The KIIM provided high-quality islets in high numbers from islet isolations from brain-dead donors. A total of 236 donor charts were reviewed and 194 pancreata (82%) were not used. Of these, 185 cases identified the reasons that the pancreata were not used. When we applied the Japanese criteria, an additional 82 cases out of 185 (44%) seem to be suitable for islet isolations. With the KIIM, more than 2,500 additional donor pancreata can be used for islet isolation in the US every year when the Japanese criteria are applied.
Spike Recognition and On-Line Classification by Unsupervised Learning System (1979)

An on-line spike recognition system allows separation of multiple spikes present on a single channel, in up to six different classes. The learning phase is unsupervised, and uses the data samples of the waveform as coordinates in a multidimensional feature space. Additional signal characteristics may improve the system performance in special cases. Using the well known nearest neighbor technique, all possible cluster configurations are determined. From this analysis, the investigator selects the physiologically best suited duster layout, primary based on a curve showing the number of clusters versus the maximum distance of two neighboring spikes in the same cluster. This procedure is supported by visual examination of the spikes of each cluster. Statistics are calculated for inter-and intracluster distances, yielding confidence limits for the cluster bounds, and estimates for the quality of separation. During the classification phase, a separate graphic display processor permits continuous control without delay. Each classified spike is projected over its cluster, identifying mean waveform.
Use of an Immunotherapeutic Vaccine to Treat a Life-Threatening Human Arteritic Infection Caused by <i>Pythium insidiosum</i> (1998)

A 14-year-old Thai boy presented because of a history of headache, mandibular swelling, and facial nerve palsy. A microorganism identified as Pythium insidiosum was cultured from the mandibular abscesses. Despite treatment with amphotericin B, iodides, ketoconazole, and surgery, the infection progressed. Magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) of the neck revealed an aneurysm in the external carotid artery. The aneurysm was removed. MRA performed later showed stenosis of the internal carotid artery. Immunotherapy was recommended as a last resort. One hundred microliters of the P. insidiosum vaccine was subcutaneously injected into the patient's left shoulder, and 14 days later a similar dose was administered. Four weeks following the first vaccination, the patient's headache had disappeared, the facial swellings had dramatically diminished, the cervical lymph node had shrunk, and the proximal left internal carotid artery stenosis had significantly improved. One year after the vaccinations, the boy was considered clinically cured.
Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi (2007)

Fusicoccins are a class of diterpene glucosides produced by the plant-pathogenic fungus Phomopsis amygdali. As modulators of 14-3-3 proteins, fusicoccins function as potent activators of plasma membrane H(+)-ATPase in plants and also exhibit unique biological activity in animal cells. Despite their well studied biological activities, no genes encoding fusicoccin biosynthetic enzymes have been identified. Cyclic diterpenes are commonly synthesized via cyclization of a C(20) precursor, geranylgeranyl diphosphate (GGDP), which is produced through condensation of the universal C(5) isoprene units dimethylallyl diphosphate and isopentenyl diphosphate by prenyltransferases. We found that (+)-fusicocca-2,10 (14)-diene, a tricyclic hydrocarbon precursor for fusicoccins, is biosynthesized from the C(5) isoprene units by an unusual multifunctional enzyme, P. amygdali fusicoccadiene synthase (PaFS), which shows both prenyltransferase and terpene cyclase activities. The functional analysis of truncated mutants and site-directed mutagenesis demonstrated that PaFS consists of two domains: a terpene cyclase domain at the N terminus and a prenyltransferase domain at the C terminus. These findings suggest that fusicoccadiene can be produced efficiently in the fungus by using the C(5) precursors, irrespective of GGDP availability. In fact, heterologous expression of PaFS alone resulted in the accumulation of fusicocca-2,10 (14)-diene in Escherichia coli cells, whereas no product was detected in E. coli cells expressing Gibberella fujikuroi ent-kaurene synthase, another fungal diterpene cyclase that also uses GGDP as a substrate but does not contain a prenyltransferase domain. Genome walking suggested that fusicoccin biosynthetic enzymes are encoded as a gene cluster near the PaFS gene.
Chemosensitization of Cancer by Nitric Oxide (2008)

Recent evidence from experimental and clinical studies links the development of intratumoral hypoxia and oxidative stress with malignant progression. Cellular adaptation induced by these environmental stresses is also associated with the emergence of drug resistant populations. This adaptation is most likely a multifactorial process involving coordination of various stress-induced signaling pathways, including those regulated by hypoxia-inducible factor-1 (HIF-1) and nuclear factor kappaB (NF-kappaB) together with their downstream targets linked to resistance mechanisms. Experimental data suggest that treatment of human cancer cells with nitric oxide (NO) and NO mimetic agents can effectively restore the sensitivity of resistant populations to the cytotoxic effects of chemotherapeutics both in vitro and in vivo. Furthermore, preliminary results from Phase II clinical trials evaluating NO as an adjuvant to chemotherapy are promising. The present review highlights the significance of intratumoral hypoxia and oxidative stress in the emergence of multidrug resistance, and summarizes the latest data demonstrating the chemosensitizing ability of NO. To date, the specific mechanisms through which NO restores sensitivity to anticancer agents are not clearly understood. However, the data suggest that chemosensitization is likely to involve NO-mediated activities associated with both prevention and inhibition of cellular drug resistance mechanisms. Potential mechanisms contributing to the chemosensitizing activity of NO include vascular changes that promote increased blood delivery and tumor oxygenation, antioxidant effects and down-regulation of the glutathione detoxification/redox buffering system, inhibition of key transcription factors such as HIF-1 and NF-kappaB, as well as inhibition of drug efflux transporters and DNA repair enzymes.
Point-of-Care RNA-Based Diagnostic Device for COVID-19 (2020)

At the end of 2019, the novel coronavirus disease (COVID-19), a fast-spreading respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was reported in Wuhan, China and has now affected over 123 countries globally [...].
Measurement of the dielectric constant of thin films by terahertz time-domain spectroscopic ellipsometry (2011)

We present a reflection-type terahertz time-domain spectroscopic ellipsometry (THz-TDSE) technique for measuring the complex dielectric constants of thin-film materials without replacement of the sample. THz-TDSE provides complex dielectric constants from the ratio of the complex amplitude reflection coefficients between p- and s-polarized THz waves. The measured dielectric constants of doped GaAs thin films show good agreement with predictions of the Drude model, even though the film thickness is of the order of a tenth of the penetration depth of the THz waves. In addition, we demonstrate the measurements of soft-phonon dispersion in SrTiO(3) thin films deposited on a Pt layer. The obtained dielectric constants agree well with the predictions of a generalized harmonic oscillator model.
Characterization of conidiation mutants in Trichoderma viride by hyphal anastomosis and protoplast fusion. (1980)

Conidiation mutants were isolated from the fungus Trichoderma viride, and tested for complementation by both anastomosis and protoplast fusion. They could be grouped into three classes: (1) colour mutants; (2) mutants with reduced conidiation; and (3) nonconidiating mutants. Several mutants of classes (2) and (3) were incapable of anastomosis, but via protoplast fusion they produced heterokaryons suitable for complementation tests.
Characterization of the Cell-Wall Polysaccharides of Arabidopsis thaliana Leaves (1995)

The cell-wall polysaccharides of Arabidopsis thaliana leaves have been isolated, purified, and characterized. The primary cell walls of all higher plants that have been studied contain cellulose, the three pectic polysaccharides homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II, the two hemicelluloses xyloglucan and glucuronoarabinoxylan, and structural glycoproteins. The cell walls of Arabidopsis leaves contain each of these components and no others that we could detect, and these cell walls are remarkable in that they are particularly rich in phosphate buffer-soluble polysaccharides (34% of the wall). The pectic polysaccharides of the purified cell walls consist of rhamnogalacturonan I (11%), rhamnogalacturonon II (8%), and homogalacturonan (23%). Xyloglucan (XG) accounts for 20% of the wall, and the oligosaccharide fragments generated from XG by endoglucanase consist of the typical subunits of other higher plant XGs. Glucuronoarabinoxylan (4%), cellulose (14%) and protein (14%) account for the remainder of the wall. Except for the phosphate buffer-soluble pectic polysaccharides, the polysaccharides of Arabidopsis leaf cell walls occur in proportions similar to those of other plants. The structure of the Arabidopsis cell-wall polysaccharides are typical of those of many other plants.
Simultaneous photoproduction of hydrogen and oxygen by photosynthesis (1979)

These results suggest that the photosynthetic production of hydrogen and oxygen represents an intriguing way to capture and convert solar energy into stored chemical free energy. It is particularly noteworthy that all three of the only known potential, direct photosynthetic water-splitting systems - blue-green algae, green algae, and the chloroplast-ferredoxin-hydrogenase system - have now been shown to photoproduce molecular hydrogen and oxygen simultaneously for prolonged periods of time. The field of hydrogenic photosynthesis is still in its infancy.
A real time contour tracking system to investigate the cross-sectional area changes of the aorta (2002)

The study of the vascular wall motion on sequences of echographic images requires the analysis of a large number of images. Therefore the tedious and time consuming process of having to manually trace the vascular contours is unacceptable. Here, the authors present an automatic and real time contour tracking procedure which they used to investigate the cross sectional changes of the aorta. The procedure is based on the computation of the mass center of the first order absolute moment (FOAM). A pure software solution based on a Personal Computer did not allow the authors to obtain real time performances. Consequently, the procedure was implemented on an integrated software/hardware environment based on the interaction of a PC and a DSP board. The quantitative assessment of the system was performed by using linear regression of the cross-sectional area of expert-traced contours and computer detected contours.
A fatal waterborne disease epidemic in Walkerton, Ontario: comparison with other waterborne outbreaks in the developed world (2003)

An estimated 2,300 people became seriously ill and seven died from exposure to microbially contaminated drinking water in the town of Walkerton, Ontario, Canada in May 2000. The severity of this drinking water disaster resulted in the Government of Ontario calling a public inquiry by Mr. Justice Dennis O'Connor to address the cause of the outbreak, the role (if any) of government policies in contributing to this outbreak and, ultimately, the implications of this experience on the safety of drinking water across the Province of Ontario. The circumstances surrounding the Walkerton tragedy are an important reference source for those concerned with providing safe drinking water. Although some circumstances are obviously specific to this epidemic, others are uncomfortably reminiscent of waterborne outbreaks that have occurred elsewhere. These recurring themes suggested the need for attention to broad issues of drinking water security and they present the challenge for how drinking water safety can be managed to prevent such tragedies in the future.
Microbial Efflux Pump Inhibition: Tactics and Strategies (2011)

Traditional antimicrobials are increasingly suffering from the emergence of multidrug resistance among pathogenic microorganisms. To overcome these deficiencies, a range of novel approaches to control microbial infections are under investigation as potential alternative treatments. Multidrug efflux is a key target of these efforts. Efflux mechanisms are broadly recognized as major components of resistance to many classes of chemotherapeutic agents as well as antimicrobials. Efflux occurs due to the activity of membrane transporter proteins widely known as Multidrug Efflux Systems (MES). They are implicated in a variety of physiological roles other than efflux and identifying natural substrates and inhibitors is an active and expanding research discipline. One plausible alternative is the combination of conventional antimicrobial agents/antibiotics with small molecules that block MES known as multidrug efflux pump inhibitors (EPIs). An array of approaches in academic and industrial research settings, varying from high-throughput screening (HTS) ventures to bioassay guided purification and determination, have yielded a number of promising EPIs in a series of pathogenic systems. This synergistic discovery platform has been exploited in translational directions beyond the potentiation of conventional antimicrobial treatments. This venture attempts to highlight different tactical elements of this platform, identifying the need for highly informative and comprehensive EPI-discovery strategies. Advances in assay development genomics, proteomics as well as the accumulation of bioactivity and structural information regarding MES facilitates the basis for a new discovery era. This platform is expanding drastically. A combination of chemogenomics and chemoinformatics approaches will integrate data mining with virtual and physical HTS ventures and populate the chemical-biological interface with a plethora of novel chemotypes. This comprehensive step will expedite the preclinical development of lead EPIs.
Accelerate convolutional neural networks for binary classification via cascading cost-sensitive feature (2016)

Convolutional Neural Networks (CNNs) have delivered impressive state-of-the-art performances for many vision tasks, while the computation costs of these networks during test-time are notorious. Empirical results have discovered that CNNs have learned the redundant representations both within and across different layers. When CNNs are applied for binary classification, we investigate a method to exploit this redundancy across layers, and construct a cascade of classifiers which explicitly balances classification accuracy and hierarchical feature extraction costs. Our method cost-sensitively selects feature points across several layers from trained networks and embeds non-expensive yet discriminative features into a cascade. Experiments on binary classification demonstrate that our framework leads to drastic test-time improvements, e.g., possible 47.2x speedup for TRECVID upper body detection, 2.82x speedup for Pascal VOC2007 People detection, 3.72x for INRIA Person detection with less than 0.5% drop in accuracies of the original networks.
Specificity of an Na+ -dependent taurocholate transport site in isolated rat hepatocytes (1984)

The structural specificity of the taurocholate uptake mechanism was studied by determining the ability of 100 microM structural analogues of taurocholate to inhibit the uptake of 5 microM [14C]-taurocholate into freshly isolated rat hepatocytes. Taurocholate was a more potent inhibitor than cholate. The fewer the number of hydroxyl groups, the more potent the inhibitors. Neither hydroxyl group orientation (alpha or beta) nor esterification with formic acid strongly influenced inhibitory potency. Replacement of hydroxyl groups with keto groups, however, diminished inhibitory potency. These facts suggested that distortion of the sterol backbone may be an important factor in diminishing inhibitory potency. Charge on the nonsteroid moiety affected potency. Both neutral and negatively charged compounds inhibited more strongly than positively charged compounds. As important as charge, however, was length of the nonsteroidal moiety. Inhibitory potency increased progressively as length beyond C-17 increased up to 11 A. Inhibitory potency was reduced again, however, with an extremely long end group of 18 A. The inhibitors do not act as cytotoxins since cellular oxygen consumption was not diminished by any of them. Furthermore, inhibition was specific for the taurocholate uptake mechanism. The three most potent inhibitory compounds inhibited L-alanine uptake little or not at all. The kinetics of inhibition, determined for three selected compounds, were consistent with competitive inhibition. The structural specificity of the rat hepatocyte sodium-dependent taurocholate uptake site is similar to that of the guinea pig ileum uptake site.
Automated tool support for ANSI/IEEE STD: 829-1983 software test documentation (2002)

The ANSI/IEEE standard for software test documentation calls for the production of a series of documents to verify that the testing process has been carried out properly and that the test objectives have been met. Without automated tool support the costs of such test documentation are prohibitive in all but the most trivial projects. The paper describes a test system which provides such a service. It begins with a test plan frame as a master class, from which the class test design is then derived. From it various test procedure classes are generated which serve to generate the individual objects -test cases specified in the form of pre- and post condition assertions to be executed in test suites.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Intracellular Ca2+ concentrations in cultured chicken photoreceptor cells: sustained elevation in depolarized cells and the role of dihydropyridine-sensitive Ca2+ channels. (1999)

The increase of [Ca2+]in elicited by depolarization with 35 mM extracellular K+ is due to influx of calcium through the dihydropyridine-sensitive voltage-gated channels. Intracellular [Ca2+] remains elevated for extended periods of time during tonic depolarization. This sustained response requires continuous Ca2+ channel activity.
PSYCHIATRIC DISORDER IN THE PARENTS OF HYPERACTIVE BOYS AND THOSE WITH CONDUCT DISORDER (1980)

SUMMARY Psychiatric diagnoses were made on parents of 126 boys attending a child psychiatric clink with information from structured interviews. Antisocial personality and alcoholism were commoner in natural fathers of aggressive, antisocial boys than in fathers of the remaining boys but the prevalence of these disorders did not distinguish fathers of hyperactive boys from fathers of those who were not hyperactive. The failure to find any association between parental disorder and hyperactivity argues against the specificity of the relationships between hyperactivity in children and alcoholism, antisocial personality and hysteria in their relatives which were discovered in earlier family studies.
Synthesis of Peptides and Pyrazines from β‐Amino Alcohols through Extrusion of H<sub>2</sub> Catalyzed by Ruthenium Pincer Complexes: Ligand‐Controlled Selectivity (2011)

Your choice: The choice of the Ru-pincer-complex catalyst determines if peptides or pyrazines are formed from β-amino alcohols. Use of PNN complex 1 leads to linear poly(alanine) or to cyclic dipeptides, depending on the R group (see scheme). With the PNP complex 2, pyrazines are formed. These reactions are homogeneously catalyzed under neutral conditions and are environmentally benign. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Norden Teaching Award 1993 Dr. James A. Roth (1993)

Dr. James Roth has again been awarded for his outstanding teaching ability. As a professor in the Iowa State University department of Microbiology, Immunology, and Preventative Medicine, Dr. Roth has won not only the Norden Teaching Award (1983,1993) but also the SCAVMA Teaching Award (1992), and the College of Veterinary Medicine Faculty Citation (1993). The Norden Award is given to a faculty member who has proven to be remarkable in their ability to teach, for their dedication to the profession of veterinary science and teaching as well as good character and leadership qualities. The selection is made by a committee of three prior Norden winners who include student input in their decision.