gebhart/patrepeval huggingface dataset:
Treatment of Resistant Port-Wine Stains with a Pulsed Dual Wavelength 595 and 1064 nm Laser: A Histochemical Evaluation of the Vessel Wall Destruction and Selectivity (2009)

Histochemical studies with NBTC stain can help the laser surgeon establish the best treatment parameters and understand some of the unwanted side effects. The dual wavelength used in this study showed efficacy, but better assessment of treatment parameters, such as the delay between the two lasers, is needed to avoid side effects.
Syndecan‐3, tenascin‐C, and the development of cartilaginous skeletal elements and joints in chick limbs (1995)

The mechanisms by which the early limb cell condensations and interzone mesenchyme give rise to skeletal elements and joints are poorly understood. Previous work from this laboratory has shown that the extracellular matrix protein tenascin-C is associated with articular cartilage and joint tissue development; others have shown that tenascin-C may exert its biological activities via interactions with cell surface receptors, such as syndecans. To further analyze the roles of tenascin-C and its putative receptors in skeletal development, we carried out a detailed in situ hybridization analysis of tenascin-C and syndecan-3 gene expression during development of chick limb skeletal elements and joints. We found that as the early mesenchymal condensations chondrify around day 5 (E5) of development, they become surrounded by a thick syndecan-3 rich perichondrium while tenascin-C transcripts are much fewer and restricted to diaphyseal perichondrium and developing interzones. Similar patterns were observed as distal carpal and digit condensations formed in older embryos. As the cartilaginous long bone models elongated proximo-distally and joint formation proceeded with age, we observed that syndecan-3 transcripts decrease significantly along the diaphysis and remain very abundant along the metaphysis and in the epiphyseal articular cap and interzone. Conversely, tenascin-C RNAs remain abundant along the diaphysis and begin to increase at the epiphysis and in interzone-derived tissues, such as menisci and joint capsule. By E10, the skeletal elements have well-defined morphologies, endochondral ossification has initiated in their diaphysis, and diaphyseal perichondrium has become periosteum. These developmental changes were accompanied by equally marked changes in gene expression; these included a marked increase in tenascin-C gene expression in articular cap, fragmentation of tenascin-C gene expression along the periosteum, reinitiation of syndecan-3 gene expression in periosteum, and differential gene expression in osteoprogenitor cells. The sheer complexity of the gene expression patterns documented in this study attests to the complexity of processes that bring about normal skelatogenesis. Clearly, tenascin-C and syndecan-3 appear to be closely associated with several of these processes, particularly in establishing tissue boundaries (perichondrium and periosteum) between condensations and surrounding mesenchymal cells, in regulating perichondral cell differentiation and incorporation into the growing skeletal elements, and in the genesis of epiphyseal chondrocytes and associated joint tissues.
Cyclooxygenase-2 Is Overexpressed in HER-2/neu-positive Breast Cancer (2002)

Markedly increased levels of cyclooxygenase-2 (COX-2) mRNA, protein, and prostaglandin E(2) synthesis were detected in HER-2/neu-transformed human mammary epithelial cells (184B5/HER) compared with its nontransformed partner cell line (184B5). HER-2/neu stimulated COX-2 transcription via the Ras --> Raf --> MAPK pathway. The inductive effects of HER-2/neu were mediated, in part, by enhanced binding of AP-1 (c-Jun, c-Fos, and ATF-2) to the cyclic AMP-response element (-59/-53) of the COX-2 promoter. The potential contribution of the transcription factor PEA3 was also investigated. Elevated levels of PEA3 were detected in 184B5/HER cells. A PEA3 site (-75/-72) was identified juxtaposed to the cyclic AMP-response element. HER-2/neu-mediated activation of the COX-2 promoter was blocked by mutagenizing the PEA3 site or overexpressing antisense to PEA3. To determine whether HER-2/neu status was also a determinant of COX-2 expression in vivo, we compared levels of COX-2 protein in HER-2/neu-positive and -negative human breast cancers. Increased amounts of COX-2 were detected in HER-2/neu-positive tumors. Taken together, these results suggest that closely spaced PEA3 and cyclic AMP-response elements are required for HER-2/neu-mediated induction of COX-2 transcription. The clear relationship between HER-2/neu status and COX-2 expression in human breast tumors suggests that this mechanism is likely to be operative in vivo.
Characterization and genome sequencing of two Propionibacterium acnes phages displaying pseudolysogeny (2011)

The investigated P. acnes Siphovirus genomes share a high degree of homology to other P. acnes phages sequenced, but not to genomes of other phages isolated from Propionibacteria. The phage genomes are not integrated in the bacterial genome, but instead, most likely have a pseudolysogenic life cycle.
Demand and Development of New Generation of Migrant Workers in Hebei Province (2018)

A field investigation was conducted on the new generation of migrant workers in Hebei Province to understand their present situation and characteristics, based on which countermeasures and suggestions were put forward to improve the survival and development of the new generation of migrant workers.
Positive solutions for a fourth-order three-point BVP with sign-changing Green's function (2018)

This paper is concerned with the following fourth-order three-point boundary value problem \begin{equation*} \begin{cases} u^{(4)}(t) = f\big(t,u(t)\big), ~t\in{[0,1]},\\ u'(0) = u''(0) = u'''(\eta) = u(1) = 0, \end{cases} \end{equation*} where $ \eta\in\big[\frac{1}{3}, 1\big)$. In spite of sign-changing Green's function, for arbitrary positive integer $n\ (\geq 2)$, we still obtain the existence of at least $n-1$ decreasing positive solutions to the above problem by imposing some suitable conditions on $f$. The main tool used is the fixed point index theory.
Information retrieval in context (2005)

IR research is now conducted in multi-media, multi-lingual, and multi-modal environments but largely in a context-free manner (Ingwersen & Järvelin, 2005). However, the retrieval of such information depends on time, place, history of interaction, task in hand, and a range of other factors that are not given explicitly but are implicit in the interaction and ambient environment, namely the context. Such contextual data can be used effectively to constrain retrieval of information thereby reducing the complexity of the retrieval process.
MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation (2015)

Conventional high-grade osteosarcoma is the most common primary bone cancer with relatively high incidence in young people. Recurrent and metastatic tumors are difficult to treat. We performed a kinase inhibitor screen in two osteosarcoma cell lines, which identified MEK1/2 inhibitors. These inhibitors were further validated in a panel of six osteosarcoma cell lines. Western blot analysis was performed to assess ERK activity and efficacy of MEK inhibition. A 3D culture system was used to validate results from 2D monolayer cultures. Gene expression analysis was performed to identify differentially expressed gene signatures in sensitive and resistant cell lines. Activation of the AKT signaling network was explored using Western blot and pharmacological inhibition. In the screen, Trametinib, AZD8330 and TAK-733 decreased cell viability by more than 50%. Validation in six osteosarcoma cell lines identified three cell lines as resistant and three as sensitive to the inhibitors. Western blot analysis of ERK activity revealed that sensitive lines had high constitutive ERK activity. Treatment with the three MEK inhibitors in a 3D culture system validated efficacy in inhibition of osteosarcoma viability. MEK1/2 inhibition represents a candidate treatment strategy for osteosarcomas displaying high MEK activity as determined by ERK phosphorylation status.
Electrical and Thermal Conductivities of 50/50 Water-ethylene Glycol Based TiO2 Nanofluids to be Used as Coolants in PEM Fuel Cells (2017)

Both thermal and electrical conductivities of nanofluids are the key parameters to be optimized for making nanofluids suitable for use as coolants in electrically active thermal applications such as fuel cells. Although nanofluids are considered to be the potential solutions as coolants for Proton Exchange Membrane (PEM) fuel cells, their high electrical conductivity is seen as a challenge in their applications. This study investigates theoretically and experimentally the electrical and thermal conductivities of 50/50 water-ethylene glycol based TiO2 nanofluids with nanoparticle concentrations in the range of 0.05-0.5 vol%. Though Maxwell model predicts decrease of electrical conductivity with increase of nanoparticle concentrations, an enormous increase of electrical conductivity (∼ 900% with 0.5 vol% at 70 °C) has been observed compared with that of the base fluid. This experimental result indicates that the Maxwell model is unable to predict the electrical conductivity of nanofluids. On the other hand, the thermal conductivity increases with the increase of concentration of nanoparticles. With 0.5 vol% nanoparticle concentration, the thermal conductivity increased by just over 10% compared to the base fluid.
Ferrite Gas Sensors (2010)

Soft ferrites are very important electronic materials because of their electrical and magnetic behavior. In last decade, remarkable efforts have been taken for the development of ferrite gas sensors in detection of toxic gas pollutants from vehicle exhaust, biological hazards, environment, and pollution monitoring. The parameters such as phase formation, crystallite size, particle size, grain size, dopants, surface area, sensitivity, selectivity, operating temperature, gas concentration, response time, and recovery time play an important role in development of ferrite gas sensors. These material for gas sensing covers number of gases such as carbon monoxide (CO), carbon dioxide (CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ), methane (CH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> ), ethyl alcohol (C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> OH), hydrogen sulphide (H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> S), C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> COOH, oxygen (O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ), hydrogen (H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ), chlorine (Cl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ), NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> , C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sub> , CH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> COOH , gasoline, acetylene, petrol, and liquefied petroleum gas (LPG). Different methods are used to prepare ferrite gas sensors. The prime requisite for developing a good quality ferrite gas sensor is optimization of preparation conditions, sintering temperature, operating temperatures, concentration of dopants, etc. It is observed that the gas sensitivity depends on kinds of semiconducting material, temperature, and test gases to be detected. This paper provides comprehensive survey of ferrites as gas sensors, such as nickel, copper, zinc, cadmium, cobalt, magnesium, manganese, and multi-component ferrites, prepared by various methods. The performance of these sensors including sensitivity, selectivity, stability, as well as response and recovery time, etc., are summarized in the table along with relevant references.
Intervencions museogràfiques a Catalunya III: Any 2017 (2019)

Cronica que recull les realitzacions museografiques -nous museus i noves o reformes d’exposicions permanents en museus, monuments i centres afins- inaugurades o obertes al public a Catalunya l’any 2015. S’informa breument de cadascuna de les inauguracions detectades, amb dades molt resumides sobre continguts i inversions, obtingudes principalment de webs i mitjans de comunicacio. Es segueix el seguent ordre (segons titularitat): museus locals, Barcelona ciutat (museus publics ), Generalitat, museus privats i centres de MD. L’objectiu es evidenciar la gran quantitat de realitzacions any rera any sense una planificacio de pais.
Polymer–Monomer Pairs as a Reaction System for the Synthesis of Magnetic Fe<sub>3</sub>O<sub>4</sub>–Polymer Hybrid Hollow Nanospheres (2004)

Magnetic hollow Fe3O4–polymer hybrid nanospheres (see figure) were prepared by adding Fe3O4 nanoparticles to an aqueous solution of polymer–monomer pairs composed of a cationic polymer (chitosan) and an anionic monomer (acrylic acid), followed by polymerization of acrylic acid and selective crosslinking of chitosan at the end of the polymerization.
The Effects of Early Childhood Teachers’ Empathy Ability and Job Stress on the Teacher-Children Interaction (2022)

본 연구는 보육교사의 공감능력 및 직무스트레스가 교사－영유아 상호작용에 미치는 영향을 확인하여, 교사－영유아 상호작용의 질과 관련된 요소를 찾아내는데 그 목적이 있다. 이에 서울과 경기, 인천 지역 어린이집에 근무하는 보육교사 212명을 대상으로, 설문지를 통해 교사－영유아 상호작용, 교사의 공감능력, 직무스트레스 자료를 수집하였다. 수집된 자료를 분석한 결과, 첫째, 교사의 공감능력은 인지적 공감이 높았고, 직무스트레스 중에서 업무 과부하가 가장 높게 나타났다. 교사가 인식하는 교사－영유아 상호작용 중에서는 교사의 또래 간 긍정적인 상호작용 촉진이 가장 높았다. 둘째, 교사의 공감능력은 기관유형, 교사 대 아동 비율에 따라 유의한 차이가 나타났으며, 직무스트레스는 담당 학급 연령, 보조교사 유무에서 유의한 차이가 있었다. 셋째, 교사의 공감능력 총점과 교사－영유아 상호작용의 총점에서 유의한 정적 상관이 나타났으며, 하위요인에서는 인지적 공감이 교사－영유아 관계형성, 교사－영유아 언어적·비언어적 상호작용, 영유아 문제 상황 지도와 고루 상관이 있었다. 반면, 직무스트레스 총점과 교사－영유아 상호작용 총점은 유의한 부적 상관이 나타났고, 직무스트레스의 모든 하위요인에서 교사－영유아 관계 형성과 부적 상관이 있었다. 공감능력과 직무스트레스의 상관관계는 유의하지 않았다. 교사의 공감능력 및 직무스트레스는 교사－영유아 상호작용에 영향을 미쳤다. 공감능력은 교사－영유아 상호작용 하위요인 모두 영향을 미쳤고, 직무스트레스는 교사－영유아 관계 형성, 교사－영유아 언어적·비언어적 상호작용에 영향을 미쳤다. 본 연구 결과에서 교사의 공감능력 중 인지적 공감이 교사－영유아 상호작용의 질을 향상시키는 요소가 된다는 것을 밝혀냈으며, 직무스트레스의 하위요인 중에서 원장의 지도력 및 행정적 지원, 업무 과부하, 동료와의 관계, 학부모와의 관계에 대한 지원이 필요하다는 근거를 제시하였다.
Target strength of liquid-filled spheres (1983)

The liquid-filled target sphere is a high target strength reflector which, since its first use in 1971, has proven to be of great utility in sonar research. The spherical metal shell filled with a low-velocity liquid is being used as a calibrated, passive, aspect-independent target. To date, the characteristics of this target have only been described in a narrow ka range by simple ray theory models. In this paper, a comprehensive treatment for 0&lt;ka&lt;100 for various shell materials and filling fluid refractive indices is presented, using results from wave theory analyses. Comparisons are made with air-filled and water-filled spheres and with solid spheres. Form function versus ka plots, echo time history, and target strength versus frequency are presented. Results show good agreement between computed and measured target strengths and permit an accurate prediction of target strength over a wide range of frequency and fluid velocities.
A randomized double-blind, placebo-controlled trial of ganaxolone in children and adolescents with fragile X syndrome (2017)

ClinicalTrials.gov, NCT01725152.
Antiviral Effects of Aphidicolin, a New Antibiotic Produced by <i>Cephalosporium aphidicola</i> (1973)

Aphidicolin is an antibiotic of novel structure produced by the mold Cephalosporium aphidicola. It is a potent inhibitor of cellular deoxyribonucleic acid synthesis, and it also strongly inhibits the growth of herpes simplex virus both in tissue culture and in the rabbit eye. Aphidicolin is active against iododeoxyuridine-resistant herpes virus, and does not itself readily induce the formation of drug-resistant strains of herpesvirus.
Drug screening platform using human induced pluripotent stem cell-derived atrial cardiomyocytes and optical mapping (2020)

Current drug development efforts for the treatment of atrial fibrillation are hampered by the fact that many preclinical models have been unsuccessful in reproducing human cardiac physiology and its response to medications. In this study, we demonstrated an approach using human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes (hiPSC-aCMs and hiPSC-vCMs, respectively) coupled with a sophisticated optical mapping system for drug screening of atrial-selective compounds in vitro. We optimized differentiation of hiPSC-aCMs by modulating the WNT and retinoid signaling pathways. Characterization of the transcriptome and proteome revealed that retinoic acid pushes the differentiation process into the atrial lineage and generated hiPSC-aCMs. Functional characterization using optical mapping showed that hiPSC-aCMs have shorter action potential durations and faster Ca<sup>2+</sup> handling dynamics compared with hiPSC-vCMs. Furthermore, pharmacological investigation of hiPSC-aCMs captured atrial-selective effects by displaying greater sensitivity to atrial-selective compounds 4-aminopyridine, AVE0118, UCL1684, and vernakalant when compared with hiPSC-vCMs. These results established that a model system incorporating hiPSC-aCMs combined with optical mapping is well-suited for preclinical drug screening of novel and targeted atrial selective compounds.
Ovarian reserve, female age and the chance for successful pregnancy. (2003)

Both quantitative and qualitative factors regarding egg production are strong influences on IVF outcome. Markers of ovarian reserve such as basal FSH, clomiphene citrate challenge test (CCCT), and antral follicle counts are good predictors of the quantity of eggs which can be induced to grow. However, the quality of those eggs seems better predicted by the age of the women. In women past age 40, current success rates are low overall, even in those who good ovarian reserve who make many eggs; at this age, quantity does not make up for quality. By contrast, young women with limited ovarian reserve can have good success rates despite their limited cohort of eggs, because the eggs themselves are of high potential; here quality matters more than quantity. The ramifications of these observations include the following: diminished ovarian reserve should not be used as an exclusionary criterion in young women, because overall they still have satisfactory pregnancy rates, though their risk of cancellation is increased. In women past age 40, normal ovarian reserve testing is not reassuring because even reduced egg quality is likely to limit the opportunity for successful pregnancy no matter how many eggs are available.
Reflections from A Humble and Much Revered Wimbledon Champion (2022)

This paper reports on a review of the post-match interviews with the Australian Ash Barty during the 2021 Wimbledon Championships. Seven transcripts were inductively content analysed to reveal six dominant themes. The analysis provides insight into Barty’s mindset and highlights the importance of her coach, support team and role model. Implications for coaches to adhere to sound coaching principles are discussed.
Navigating the terahertz gap (2020)

The terahertz range has been barely exploited compared to the rest of the electromagnetic spectrum. But as Sidney Perkowitz argues, our ability to detect radiation at these wavelengths has proved vital in many areas of astronomy and cosmology
The Six-Port Reflectometer: An Alternative Network Analyzer (2005)

Although the six-port measurement technique is rapidly gaining the attention of the microwave community, theoretical development, to date, yields but limited intuitive insight into how the technique actually works. This paper presents an alternative introduction to the general subject which provides this insight.
Analysis of granulocyte‐reactive antibodies using an immunoassay based upon monoclonal‐antibody‐specific immobilization of granulocyte antigens (1993)

To detect human granulocyte-reactive antibodies, a glycoprotein-specific enzyme immunoassay for platelet antibodies was adapted for the use of granulocytes as target cells. Peripheral blood granulocytes were simultaneously incubated with a monoclonal antibody (mAb) and the serum to be investigated. After solubilization, aliquots of the cell lysate were transferred to plastic tubes coated with goat anti-mouse antibodies. Following immobilization of the trimolecular (mAb-glycoprotein-human antibody) complex it was detected by addition of enzyme-labelled goat anti-human antibodies using a luminescence technique. This assay allowed identification of different granulocyte-reactive antibodies present in the same sample without the need for complicated absorption studies. Alloantibodies against HLA and the granulocyte-specific NA antigens as well as isoantibodies against the Fc-gamma-receptor III (FcRIII) were detectable using mAb-specific immobilization of granulocyte antigens (MAIGA). Binding of autoantibodies to the FcRIII and to the CD 11b/CD18 complex could be shown.
Predicting Blood−Brain Barrier Permeation from Three-Dimensional Molecular Structure (2000)

Predicting blood-brain barrier (BBB) permeation remains a challenge in drug design. Since it is impossible to determine experimentally the BBB partitioning of large numbers of preclinical candidates, alternative evaluation methods based on computerized models are desirable. The present study was conducted to demonstrate the value of descriptors derived from 3D molecular fields in estimating the BBB permeation of a large set of compounds and to produce a simple mathematical model suitable for external prediction. The method used (VolSurf) transforms 3D fields into descriptors and correlates them to the experimental permeation by a discriminant partial least squares procedure. The model obtained here correctly predicts more than 90% of the BBB permeation data. By quantifying the favorable and unfavorable contributions of physicochemical and structural properties, it also offers valuable insights for drug design, pharmacological profiling, and screening. The computational procedure is fully automated and quite fast. The method thus appears as a valuable new tool in virtual screening where selection or prioritization of candidates is required from large collections of compounds.
Altered pharmacology of native rodent spinal cord <scp>TRPV</scp>1 after phosphorylation (2012)

Our findings indicate that both TRPV1 agonist and antagonist profiles can be differentially altered by PKC activation. These findings may offer new insights for targeting TRPV1 in pain states.