gebhart/patrepeval huggingface dataset:
SECOND GENERATION ADVANCED REBURNING FOR HIGH EFFICIENCY NOx CONTROL (1999)

This project is designed to develop a family of novel NO{sub x} control technologies, called Second Generation Advanced Reburning which has the potential to achieve 90+ NO{sub x} control in coal fired boilers at a significantly lower cost than Selective Catalytic Reduction. The sixth reporting period in Phase II (January 1-March 31, 1999) included experimental activities and combined chemistry-mixing modeling on advanced gas reburning. The goal of combustion tests was to continue the work on identifying prospective promoters for the advanced reburning process. Tests were conducted in Controlled Temperature Tower (CTT) and Boiler Simulator Facility (BSF). Tests showed that some promoters significantly affect the reburning process when co-injected with NH{sub 3} . The promoters injected into reburning zone without NH{sub 3} in the amount 30 ppm do not significantly affect the reburning process. The modeling effort was focused on the description of Na effect on CO emissions in advanced reburning. Increase in CO concentration in flue gas upon Na injection results from inhibition of CO oxidation by Na species in the burnout zone.
Human antibody repertoire frequently includes antibodies to a bacterial biofilm associated protein (2019)

We have previously described a native human monoclonal antibody, TRL1068, that disrupts bacterial biofilms by extracting from the biofilm matrix key scaffolding proteins in the DNABII family, which are present in both gram positive and gram negative bacterial species. The antibiotic resistant sessile bacteria released from the biofilm then revert to the antibiotic sensitive planktonic state. Qualitative resensitization to antibiotics has been demonstrated in three rodent models of acute infections. We report here the surprising discovery that antibodies against the target family were found in all twenty healthy humans surveyed, albeit at a low level requiring a sensitive single B-cell assay for detection. We have cloned 21 such antibodies. Aside from TRL1068, only one (TRL1330) has all the biochemical properties believed necessary for pharmacological efficacy (broad spectrum epitope specificity and high affinity). We suggest that the other anti-DNABII antibodies, while not necessarily curative, reflect an immune response at some point in the donor's history to these components of biofilms. Such an immune response could reflect exposure to bacterial reservoirs that have been previously described in chronic non-healing wounds, periodontal disease, chronic obstructive pulmonary disease, colorectal cancer, rheumatoid arthritis, and atherosclerotic artery explants. The detection of anti-DNABII antibodies in all twenty surveyed donors with no active infection suggests that bacterial biofilm reservoirs may be present periodically in most healthy individuals. Biofilms routinely shed bacteria, creating a continuous low level inflammatory stimulus. Since chronic subclinical inflammation is thought to contribute to most aging-related diseases, suppression of bacterial biofilm has potential value in delaying age-related pathology.
Specific splice variants are associated with Parkinson's disease (2013)

These results support the view that differential expression of a subset of splice-variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at-risk subjects is warranted.
Dynamics Suppression in Liquid-Fueled Combustors Using Fuel Modulation (2012)

In the present work, an atmospheric pressure combustor using a modern aviation gas turbine fuel nozzle was used to demonstrate active combustion control. The combustor exhibited a low-frequency dynamics mode under fuel-rich conditions. A fast-response fuel valve was adapted as an in-line valve upstream of the nozzle for fuel modulation. Large fuel modulation amplitudes were achieved with the combination of the valve and the engine nozzle at frequencies exceeding 200 Hz. Open-loop flame response to fuel modulation was first examined when the instability mode was absent; for a range of inlet air temperatures, fuel flow rates, and combustor pressure drops. Simple open-loop control at discrete off-resonance frequencies was found ineffective in suppressing the instability mode. An advanced, fast algorithm was developed to enable closed-loop control. In this scheme, the entire fuel supply to the combustor was modulated with the control valve and injected through the fuel nozzle. The control algorithm commanded the fuel injector to produce a steady fuel flow, when the combustion was stable, or to modulate the fuel when the level of pressure oscillations in the combustion chamber became unacceptable. With an optimized control algorithm, an 88% reduction in the amplitude of the low-frequency dynamics mode was achieved.
Mkks-null mice have a phenotype resembling Bardet–Biedl syndrome (2005)

McKusick-Kaufman syndrome (MKS) is an autosomal recessive disorder characterized by post-axial polydactyly, congenital heart defects and hydrometrocolpos, a congenital structural abnormality of female genitalia. Mutations in the MKKS gene have also been shown to cause some cases of Bardet-Biedl syndrome (BBS) which is characterized by obesity, pigmentary retinopathy, polydactyly, renal abnormalities and hypogenitalism with secondary features of hypertension and diabetes. Although there is overlap in clinical features between MKS and BBS, MKS patients are not obese and do not develop retinopathy or have learning disabilities. To further explore the pathophysiology of BBS and the related disorder MKS, we have developed an Mkks(-/-) mouse model. This model shows that the absence of Mkks leads to retinal degeneration through apoptosis, failure of spermatozoa flagella formation, elevated blood pressure and obesity. The obesity is associated with hyperphagia and decreased activity. In addition, neurological screening reveals deficits in olfaction and social dominance. The mice do not have polydactyly or vaginal abnormalities. The phenotype of the Mkks(-/-) mice closely resembles the phenotype of other mouse models of BBS (Bbs2(-/-) and Bbs4(-/-)). These observations suggest that the complete absence of MKKS leads to BBS while the MKS phenotype is likely to be due to specific mutations.
Interactive search in large video collections (2005)

We present a search interface for large video collections with time-aligned text transcripts. The system is designed for users such as intelligence analysts that need to quickly find video clips relevant to a topic expressed in text and images. A key component of the system is a powerful and flexible user interface that incorporates dynamic visualizations of the underlying multimedia objects. The interface displays search results in ranked sets of story keyframe collages, and lets users explore the shots in a story. By adapting the keyframe collages based on query relevance and indicating which portions of the video have already been explored, we enable users to quickly find relevant sections. We tested our system as part of the NIST TRECVID interactive search evaluation, and found that our user interface enabled users to find more relevant results within the allotted time than those of many systems employing more sophisticated analysis techniques.
Mutational analysis of the hepatitis C virus RNA helicase (1997)

The carboxyl-terminal three-fourths of the hepatitis C virus (HCV) NS3 protein has been shown to possess an RNA helicase activity, typical of members of the DEAD box family of RNA helicases. In addition, the NS3 protein contains four amino acid motifs conserved in DEAD box proteins. In order to inspect the roles of individual amino acid residues in the four conserved motifs (AXXXXGKS, DECH, TAT, and QRRGRTGR) of the NS3 protein, mutational analysis was used in this study. Thirteen mutant proteins were constructed, and their biochemical activities were examined. Lys1235 in the AXXXXGKS motif was important for basal nucleoside triphosphatase (NTPase) activity in the absence of polynucleotide cofactor. A serine in the X position of the DEXH motif disrupted the NTPase and RNA helicase activities. Alanine substitution at His1318 of the DEXH motif made the protein possess high NTPase activity. In addition, we now report inhibition of NTPase activity of NS3 by polynucleotide cofactor. Gln1486 was indispensable for the enzyme activity, and this residue represents a distinguishing feature between DEAD box and DEXH proteins. There are four Arg residues in the QRRGRTGR motif of the HCV NS3 protein, and the second, Arg1488, was important for RNA binding and enzyme activity, even though it is less well conserved than other Arg residues. Arg1490 and Arg1493 were essential for the enzymatic activity. As the various enzymatic activities were altered by mutation, the enzyme characteristics were also changed.
Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors (2015)

Inhibitors of sirtuin-2 (SIRT2) deacetylase have been shown to be protective in various models of Huntington's disease (HD) by decreasing polyglutamine aggregation, a hallmark of HD pathology. The present study was directed at optimizing the potency of SIRT2 inhibitors containing the 3-(benzylsulfonamido)benzamide scaffold and improving their metabolic stability. Molecular modeling and docking studies revealed an unfavorable role of the sulfonamide moiety for SIRT2 binding. This prompted us to replace the sulfonamide with thioether, sulfoxide, or sulfone groups. The thioether analogues were the most potent SIRT2 inhibitors with a two- to three-fold increase in potency relative to their corresponding sulfonamide analogues. The newly synthesized compounds also demonstrated higher SIRT2 selectivity over SIRT1 and SIRT3. Two thioether-derived compounds (17 and 18) increased α-tubulin acetylation in a dose-dependent manner in at least one neuronal cell line, and 18 was found to inhibit polyglutamine aggregation in PC12 cells.
Exceptional Molecular Hyperpolarizabilities in Twisted π‐Electron System Chromophores (2005)

Nonlinear optics: Twisted π-electron system electrooptic (EO) chromophores with exceptional molecular hyperpolarizabilities (−488 000×10−48 esu at 1907 nm) were designed and synthesized. Crystallographic analysis reveals large twist angles and a highly charge-separated zwitterionic ground state. Experiments on poled host–guest polymers containing these chromophores show them to be promising candidates for EO applications. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z501581_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Accessing thermoplastic processing windows in metallic glasses using rapid capacitive discharge (2014)

The ability of the rapid-capacitive discharge approach to access optimal viscosity ranges in metallic glasses for thermoplastic processing is explored. Using high-speed thermal imaging, the heating uniformity and stability against crystallization of Zr35Ti30Cu7.5Be27.5 metallic glass heated deeply into the supercooled region is investigated. The method enables homogeneous volumetric heating of bulk samples throughout the entire supercooled liquid region at high rates (~10(5) K/s) sufficient to bypass crystallization throughout. The crystallization onsets at temperatures in the vicinity of the "crystallization nose" were identified and a Time-Temperature-Transformation diagram is constructed, revealing a "critical heating rate" for the metallic glass of ~1000 K/s. Thermoplastic process windows in the optimal viscosity range of 10(0)-10(4) Pa · s are identified, being confined between the glass relaxation and the eutectic crystallization transition. Within this process window, near-net forging of a fine precision metallic glass part is demonstrated.
V-band transmission and reflection grid amplifier packaged in waveguide (2003)

We designed and demonstrated two monolithic V-band grid amplifiers packaged in waveguides. We measured a 2 dB small-signal system gain for both transmission and reflection amplifiers. This is the first monolithic grid amplifier packaged and measured in a waveguide in the V-band.
Sacrificial‐Post Templating Method for Block Copolymer Self‐Assembly (2013)

A sacrificial-post templating method is presented for directing block copolymer self-assembly to form nanostructures consisting of monolayers and bilayers of microdomains. In this approach, the topographical post template is removed after self-assembly and therefore is not incorporated into the final microdomain pattern. Arrays of nanoscale holes of different shapes and symmetries, including mesh structures and perforated lamellae with a bimodal pore size distribution, are produced. The ratio of the pore sizes in the bimodal distributions can be varied via the template pitch, and agrees with predictions of self consistent field theory.
Interaction of positron beams with surfaces, thin films, and interfaces (1988)

Recent advances in the study of solid surfaces and thin films using variable-energy positron beams are reviewed. In the first part the authors discuss the process of positron moderation and technical aspects of positron beam production and application. The second part is (roughly) organized in sections that apply to increasing time scales appropriate to the positron-solid interaction. These are (a) first encounter and scattering effects, (b) energy loss and stopping profiles, (c) diffusion of thermalized positrons, (d) positron-surface interactions, and (e) studies of defects near surfaces and interfaces. The review is written with more emphasis on the most recent measurements and interpretations than on the chronology of various developments.
An LC compensated electric field repeater for long distance capacitive power transfer (2016)

This paper proposes an LC-compensated electric field repeater to extend the transfer distance of a capacitive power transfer (CPT) system. The repeater contains two metal plates, connected with an external capacitor and an external inductor. The plates are used to generate electric fields to transfer power. The external inductor and capacitor are used to resonate with the plates to increase the voltage levels. The repeater is placed between a transmitter and a receiver, which also contains metal plates compensated by an LC network. The repeater can increase the transfer distance of the CPT system without significantly influencing the system power and efficiency. In this paper, the capacitive coupler structure and dimensions are designed and simulated using Maxwell software. Considering all the capacitive coupling between plates, an equivalent circuit model is derived. The fundamental harmonics approximation method is used to analyze the working principle of the circuit. A 150W input power CPT system is designed as an example to validate the proposed repeater structure and compensation circuit topology. The system can achieve an efficiency of 66.9% from dc source to dc load, when the transfer distance is 360 mm and the repeater is placed between the transmitter and receiver.
A Carbon Slurry Separated Interface Nerve Electrode for Electrical Block of Nerve Conduction (2019)

Direct current (DC) nerve block has been shown to provide a complete block of nerve conduction without unwanted neural firing. Previous work shows that high capacitance electrodes can be used to safely deliver a DC block. Another way of delivering DC safely is through a separated interface nerve electrode (SINE), such that any reactive species that are generated by the passage of DC are contained in a vessel away from the nerve. This design has been enhanced by using a high capacitance carbon "slurry" as the electrode in the external vessel to extend the capacity of the electrode (CSINE). With this new design, it was possible to provide 50 min of continuous nerve block without recharge while still maintaining complete recovery of neural signals. Up to 46 C of charge delivery was applied for a total of 4 h of nerve block with complete recovery. Because of the extended delivery time, it was possible to explore several properties of DC block that would not be revealed without the capability of a long-duration continuous block. It was possible to achieve complete block at lower values of DC if the block was applied for a longer period of time. Depending on the amount of charge applied during the block, the recovery was delayed for a period of time before complete force recovery was restored. These new properties provide novel techniques for device development to optimize charge delivery time and device powering concerns.
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma (2018)

Class I histone deacetylases (HDACs) are highly expressed and/or upregulated in hepatocellular carcinoma (HCC) and are associated with aggressiveness, spread, and increased mortality of HCC. Activation of phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway was involved in the development of HCC and acquired resistance to sorafenib. A series of purine or 5H-pyrrolo[3,2-d]pyrimidine based hydroxamates were designed and developed as multitarget drugs to modulate both HDACs and the PI3K/Akt/mTOR pathway. Among 39 cell lines screened, the molecules (e.g., 20e, 20f, and 20q) were the most selective against leukemia, lymphoma, and HCC cells; they also demonstrated target modulation in cancer cell lines and in mice bearing MV4-11 and HepG2 tumors. Compound 20f in particular showed significant single agent oral efficacy in hypervascular liver cancer models (e.g., HepG2, HuH-7, and Hep3B) and was well-tolerated. These encouraging results, along with its favorable target profile and tissue distribution, warrant further development of 20f.
Autonomous Real-Time Objects Tracking With An Adaptive Joint Transform Correlator (1989)

A hybrid optical/digital system for objects tracking in a sequence of images is described. The backbone of the system is a real-time optical joint transform correlator using a liquid crystal television. The massive parallelism, high processing speed and adaptive property of this optical system assure high correlation between objects in two sequential frames. The relative position of the object can then be determined based on the location of the correlation peak. System performance is evaluated and experimental demonstrations are presented. This system also has the potential to perform real-time multi-object tracking.
Method for learning deep features for correlation based visual tracking (2017)

In this paper, we address the problem of visual tracking by proposing a novel feature learning technique. Recently, correlation filter based methods have dominated the visual tracking community due to various reasons such as efficient dense matching in frequency domain and simple update strategy. Nevertheless, the studies of correlation filters utilize handcrafted or pre-trained deep features of classification task without considering the correlation filter cost function. Thus, we attempt to learn deep convolutional features for correlation filter based object tracking. In our experiments on benchmark sequences, we observe a significant improvement over the hand-crafted features while decreasing the number of features utilized in the recent correlation filter based trackers.
A Novel Thermoreversible Gelling Product Made by Enzymatic Modification of Starch (2005)

Amylomaltases or D-enzyme (4-α-glucanotransferases; E.C. 2.4.1.25) are carbohydrate-active enzymes that catalyze the transfer of glucan units from one α-glucan to another in a disproportionation reaction. These enzymes are involved in starch metabolism in plants or maltose/glycogen metabolism in many microorganisms. The amylomaltase of the hyperthermophilic bacterium Thermus thermophilus HB8 was overproduced in Escherichia coli, partially purified and used to modify potato starch. The action of amylomaltase caused the disappearance of amylose and the broadening of the side-chain length distribution in amylopectin, which resulted in a product with both shorter and longer side chains than in the parent starch. Amylomaltase-treated potato starch showed thermoreversible gelation at concentrations of 3% (w/v) or more, thus making it comparable to gelatin. Because of its animal origin, gelatin is not accepted by several consumer groups. Therefore, the amylomaltase-treated potato starch might be a good plant-derived substitute for gelatin.
Quantitative image‐based spectral reconstruction for computed tomography (2009)

Computed tomography (CT) devices are routinely employed to obtain three-dimensional images of the human body. The reconstructed CT numbers represent weighted x-ray attenuation coefficients. Their spectral weighting is influenced by the selected x-ray source spectrum, the detector characteristics, and the attenuating object itself. The quantitative ground truth of the scanned object is given by the spectral attenuation coefficient. It is not directly measurable in standard CT. For spectral CT measurements, algorithms like the basis material decomposition yield parametrized representations of the spectral mass attenuation coefficient. In practical applications, image-based formulations are commonly used. They are affected by both the CT system characteristics and the object self-attenuation effects. In this article the authors introduce an image-based spectral CT method. It expresses measured CT data as a spectral integration of the spectral attenuation coefficient multiplied by a local weighting function (LWF). The LWF represents the local energy weighting in the image domain, taking into account the system and reconstruction properties and the object self-attenuation. A generalized image-based formulation of spectral CT algorithms is obtained, with no need for additional corrections of, e.g., beam hardening. The iterative procedure called local spectral reconstruction yields both the mass attenuation coefficients of the object and a representation of the LWF. The quantitative accuracy and precision of the method are investigated in several applications: First, beam hardening corrections to various target energy weightings and attenuation correction maps for SPECT/CT and PET/CT are calculated. Second, an iodine density evaluation is performed. Finally, a direct identification of spectral attenuation functions using the LWF result is demonstrated. In all applications, the ground truth of the objects is reproduced with a quantitative accuracy in the subpercent to 2% range. An exponential convergence behavior of the iterative procedure is observed, with one to two iteration steps as a good compromise between quantitative accuracy and precision. The authors conclude that the method can be used to perform image-based spectral CT reconstructions with quantitative accuracy. Existing algorithms benefit from the intrinsic treatment of beam hardening and system properties. Novel algorithms are enabled to directly compare material model functions to spectral measurement data.