gebhart/patrepeval huggingface dataset:
Fully integrated standard cell digital PLL (2001)

A fully integrated digital phase-locked loop (PLL) used as a clock multiplying circuit is designed. The PLL is made from standard cells found in almost any commercial standard cell library and therefore portable between processes in netlist format. Using a 0.35 µm standard complementary metal-oxide-semicondctor CMOS process and a 3.0 V supply voltage, the PLL is designed for a locking range of 170 to 360 MHz and occupies an on-chip area of 0.06 mm2.
Stereo Matching Based on Double-density Dual-tree Complex Wavelet Transform (2012)

Stereo matching is becoming the focus of computer vision research in recent years,it aims to explore a more ideal stereo matching algorithm by doing research and experiments to improve the robustness of image matching.Double-density dual-tree complex wavelet has the advantages of multi-resolution,limited data redundancy and translational invariance.According to these advantages of double-density dual-tree complex wavelet,proposed a phase-matching algorithm,its principle is to extract multi-scale phase information as a three-dimensional like a pair matching primitives,and then use the pyramid model to achieve matching.First match the lowest resolution level,layer by layer and then push forward until the layer which is the most advanced,and use the upper matching the parallax results to guide the phase matching of the channels in this layer,forming a multi-resolution level matching framework,call it the framework of the image pyramid structure.The author uses this method to ultimately achieve the expected experimental results.The experimental results show that by this method get a dense disparity map,which has the highly accurate matching results,at present it is the most ideal stereo matching algorithm.
Large‐Scale Production of Adult Stem Cells for Clinical Use (2009)

This chapter contains sections titled: Cell Therapy Manufacture of Cell Products for Therapy Regulatory Requirements for Cell Products Cell Culture Processes Importance of Medium Exchange for Maintenance of Hematopoietic Stem Cells Bioreactor Design Capable of Supporting the Biologic Process Cell Manufacturing System Postculture Processing of Cell Products Depletion of Culture Residuals from the Cell Product Summary Acknowledgments References
A model of interorganelle monoclonal antibody transport and secretion in mouse hybridoma cells (1991)

A three compartment model (ER --> Golgi --> extracellular medium) is used here to describe the interorganelle transport and final secretion of an IgG(2a) monoclonal antibody (MAb) in 9.2.27 murine hybridoma cells. Model simulations of pulse-chase and continuous labeling experiments are used to gain a better understanding of the kinetics of MAb interorganelle traffic. Simulation results for the continuous labeling case compare well with experimental data obtained during continuous labeling of 9.2.27 hybridoma cells. Incorporation of this compartmental transport model into our previously developed model of MAb synthesis and assembly can provide a useful tool for analyzing the dynamics and regulation of the complete antibody secretory pathway under different growth and/or nutritional conditions.
Automated Analysis of Sewer Inspection Closed Circuit Television Videos Using Image Processing Techniques (2013)

A Thesis Submitted to the Faculty of Graduate Studies and Research In Partial Fulfillment of the Requirements for the Degree of Master of Applied Science in Software Systems Engineering, University of Regina. xiii , 136 p.
Caged Chemotactic Peptides (2000)

This work has as its ultimate goal the creation of a concentration spike of a chemoattractant peptide in a time-resolved and spatially defined way using a light pulse. This strategy requires "caging" the peptide with a photochemically removable group. Model studies used alanine ethyl ester in reductive amination with nitrobenzaldehydes to form two different N-nitrobenzyl derivatives. An fMLF peptide bearing these two N-terminal nitrobenzyl groups was also prepared. The yield and kinetics of their deprotection to return the fMLF peptide were determined. It was established that the caged peptides have vastly reduced biological activity as chemoattractants, as designed.
A SIMPLE ALGORITHM FOR IDENTIFYING ABBREVIATION DEFINITIONS IN BIOMEDICAL TEXT (2002)

The volume of biomedical text is growing at a fast rate, creating challenges for humans and computer systems alike. One of these challenges arises from the frequent use of novel abbreviations in these texts, thus requiring that biomedical lexical ontologies be continually updated. In this paper we show that the problem of identifying abbreviations' definitions can be solved with a much simpler algorithm than that proposed by other research efforts. The algorithm achieves 96% precision and 82% recall on a standard test collection, which is at least as good as existing approaches. It also achieves 95% precision and 82% recall on another, larger test set. A notable advantage of the algorithm is that, unlike other approaches, it does not require any training data.
A Quantitative Study of Gene Regulation Involved in the Immune Response of Anopheline Mosquitoes (2006)

Malaria represents one of the major worldwide challenges to public health. A recent breakthrough in the study of the disease follows the annotation of the genome of the malaria parasite Plasmodium falciparum and the mosquito vector (an organism that spreads an infectious disease)Anopheles. Of particular interest is the molecular biology underlying the immune response system of Anopheles, which actively fights against Plasmodium infection. This article reports a statistical analysis of gene expression time profiles from mosquitoes that have been infected with a bacterial agent. Specifically, we introduce a Bayesian model-based hierarchical clustering algorithm for curve data to investigate mechanisms of regulation in the genes concerned; that is, we aim to cluster genes having similar expression profiles. Genes displaying similar, interesting profiles can then be highlighted for further investigation by the experimenter. We show how our approach reveals structure within the data not captured by other approaches. One of the most pertinent features of the data is the sample size, which records the expression levels of 2,771 genes at 6 time points. Additionally, the time points are unequally spaced, and there is expected nonstationary behavior in the gene profiles. We demonstrate our approach to be readily implementable under these conditions, and highlight some crucial computational savings that can be made in the context of a fully Bayesian analysis.
Asymptotic Mean Squared Error Performance of Diagonally Loaded Capon-MVDR Processor (2006)

The asymptotic local mean squared error (MSE) performance of the Capon algorithm, a.k.a the minimum variance distortionless response (MVDR) spectral estimator, has been studied extensively by several authors. Stoica et al. [21], Vaidyanathan and Buckley [23], and Hawkes and Nehorai [11] have exploited Taylor’s theorem and complex gradient methods to provide accurate prediction of the Capon algorithm signal parameter estimate MSE performance. These predictions are valid (i) above the estimation threshold signal-to-noise ratio (SNR) and (ii) provided a sufficient number of training samples is available for covariance estimation. The goal of this present analysis is to extend these results to the case in which the sample covariance matrix is diagonally loaded, as is often done in practice for regularization, stabilizing matrix inversion, and white noise gain control [7]. Recent advances in the theory of random matrices with large dimensions facilitate simple calculation of the required moments of the eigenvalues of several modified complex Wishart matrices including the inverse of the diagonally loaded case [14, 16]. This initial work focuses on the MSE prediction of angle estimates derived for the canonical case of single and multiple planewave signals in white noise.
GDNF and NGF Reverse Changes in Repriming of TTX-Sensitive Na<sup>+</sup> Currents Following Axotomy of Dorsal Root Ganglion Neurons (2002)

Uninjured C-type rat dorsal root ganglion (DRG) neurons predominantly express slowly inactivating TTX-resistant (TTX-R) and slowly repriming TTX-sensitive (TTX-S) Na(+) currents. After peripheral axotomy, TTX-R current density is reduced and rapidly repriming TTX-S currents emerge and predominate. The change in TTX-S repriming kinetics is paralleled by an increase in the level of transcripts and protein for the Na(v)1.3 sodium channel alpha-subunit, which is known to exhibit rapid repriming. Changes in Na(+) current profile and kinetics in DRG neurons may substantially alter neuronal excitability and could contribute to some states of chronic pain associated with injury of sensory neurons. In the present study, we asked whether glial-derived neurotrophic factor (GDNF) and nerve growth factor (NGF), which have been shown to prevent some axotomy-induced changes such as the loss of TTX-R Na(+) current expression in DRG neurons, can ameliorate the axotomy-induced change in TTX-S Na(+) current repriming kinetics. We show that intrathecally administered GDNF and NGF, delivered individually, can partially reverse the effect of axotomy on the repriming kinetics of TTX-S Na(+) currents. When GDNF and NGF were co-administered, the repriming kinetics were fully rescued. We observed parallel effects of GDNF and NGF on the Na(v)1.3 sodium channel transcript levels in axotomized DRG. Both GDNF and NGF were able to partially reverse the axotomy-induced increase in Na(v)1.3 mRNA, with GDNF plus NGF producing the largest effect. Our data indicate that both GDNF and NGF can partially reverse an important effect of axotomy on the electrogenic properties of sensory neurons and that their effect is additive.
Transputer based harmonic-elimination PWM control of inverter drives (2003)

The implementation and generation of harmonic elimination pulse-width modulation (PWM) techniques using the parallel processing INMOS transputer are presented, and the concurrent programming ability of the transputer for PWM generation is emphasized. The implementation of the PWM strategy can also be performed on any standard 8- or 16-bit microprocessor using four- or one-timer implementation. Results from an experimental transputer-controlled PWM inverter drive are presented to demonstrate and confirm the special feature of the regular-sampled harmonic elimination PWM control strategies.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nuclear relaxation of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">He</mml:mi></mml:mrow><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>3</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow></mml:math>in the presence of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (1995)

We have measured the longitudinal nuclear relaxation rate ${\mathit{T}}_{1}^{\mathrm{\ensuremath{-}}1}$ for $^{3}\mathrm{He}$ in the presence of molecular oxygen in the temperature range T\ensuremath{\approxeq}200--400 K. At room temperature, ${\mathit{T}}_{1}^{\mathrm{\ensuremath{-}}1}$=0.448\ifmmode\pm\else\textpm\fi{}0.010 ${\mathrm{s}}^{\mathrm{\ensuremath{-}}1}$ per amagat ${\mathrm{O}}_{2}$, in approximate agreement with theoretical models for intermolecular dipolar relaxation. Furthermore, in this temperature range, ${\mathit{T}}_{1}^{\mathrm{\ensuremath{-}}1}$\ensuremath{\propto}${\mathit{T}}^{\mathrm{\ensuremath{-}}0.42\ifmmode\pm\else\textpm\fi{}0.04}$. Our results are of practical importance for the growing number of applications involving hyperpolarized noble gases.
Development of a metrology frame to improve the positioning accuracy of Micro/Meso-scale Machine Tools (2009)

The small work volumes of Micro/Meso-scale Machine Tools (MMMTs) often present problems for calibration and error compensation, but also allow solutions not practical on the traditional scale. Measuring tool position with a separate metrology frame and compensating for error motions is one such solution. The metrology frame design follows principles of precision design and allows measurement of the position of the tool tip with respect to the workpiece while minimising Abbe errors. Kinematic analysis provides the relationship between metrology frame measurements and machine tool coordinates. Error analysis reveals that sensor error has the only first order influence on measurement accuracy.
A preliminary study to demonstrate the use of an air bag device to prevent fall-related injuries (2007)

We sought to develop a fall-related injury prevention system using a telemetry acceleration monitor and an air bag. In a preliminary study, we developed a fall detection system using an acceleration signal and triggering the inflation of an air bag. Sixteen subjects mimicked falls and their acceleration waveforms were monitored. Then, we developed a fall detection algorithm that could detect signals 300 ms before the fall. This signal was used as a trigger to inflate the air bag to a capacity of 2.4 L. While the proposed system can aid in preventing fall-related injuries, further development is needed to miniaturize the inflation system.
Increased presence of effector lymphocytes during<i>Helicobacter hepaticus</i>-induced colitis (2012)

Data suggest that defects in SMAD3 signaling increase susceptibility to H. hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes.
Optimum Settings for Automatic Controllers (1993)

In this paper, the three principal control effects found in present controllers are examined and practical names and units of measurement are proposed for each effect. Corresponding units are proposed for a classification of industrial processes in terms of the two principal characteristics affecting their controllability. Formulas are given which enable the controller settings to be determined from the experimental or calculated values of the lag and unit reaction rate of the process to be controlled. These units form the basis of a quick method for adjusting a controller on the job. The effect of varying each controller setting is shown in a series of chart records. It is believed that the conceptions of control presented in this paper will be of assistance in the adjustment of existing controller applications and in the design of new installations.
Improved approximations of packing and covering problems (1995)

Article Free Access Share on Improved approximations of packing and covering problems Author: Aravind Srinivasan School of Mathematics, Institute for Advanced Study, Princeton, NJ and DIMACS (NSF Center for Discrete Mathematics and Theoretical Computer Science), Rutgers University, Piscataway, NJ School of Mathematics, Institute for Advanced Study, Princeton, NJ and DIMACS (NSF Center for Discrete Mathematics and Theoretical Computer Science), Rutgers University, Piscataway, NJView Profile Authors Info & Claims STOC '95: Proceedings of the twenty-seventh annual ACM symposium on Theory of computingMay 1995 Pages 268–276https://doi.org/10.1145/225058.225138Online:29 May 1995Publication History 55citation1,107DownloadsMetricsTotal Citations55Total Downloads1,107Last 12 Months47Last 6 weeks13 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Well-defined porous membranes for robust omniphobic surfaces via microfluidic emulsion templating (2017)

Durability is a long-standing challenge in designing liquid-repellent surfaces. A high-performance omniphobic surface must robustly repel liquids, while maintaining mechanical/chemical stability. However, liquid repellency and mechanical durability are generally mutually exclusive properties for many omniphobic surfaces-improving one performance inevitably results in decreased performance in another. Here we report well-defined porous membranes for durable omniphobic surfaces inspired by the springtail cuticle. The omniphobicity is shown via an amphiphilic material micro-textured with re-entrant surface morphology; the mechanical durability arises from the interconnected microstructures. The innovative fabrication method-termed microfluidic emulsion templating-is facile, cost-effective, scalable and can precisely engineer the structural topographies. The robust omniphobic surface is expected to open up new avenues for diverse applications due to its mechanical and chemical robustness, transparency, reversible Cassie-Wenzel transition, transferability, flexibility and stretchability.
Cyt1A of <i>Bacillus thuringiensis</i> Delays Evolution of Resistance to Cry11A in the Mosquito <i>Culex quinquefasciatus</i> (2005)

Insecticides based on Bacillus thuringiensis subsp. israelensis have been used for mosquito and blackfly control for more than 20 years, yet no resistance to this bacterium has been reported. Moreover, in contrast to B. thuringiensis subspecies toxic to coleopteran or lepidopteran larvae, only low levels of resistance to B. thuringiensis subsp. israelensis have been obtained in laboratory experiments where mosquito larvae were placed under heavy selection pressure for more than 30 generations. Selection of Culex quinquefasciatus with mutants of B. thuringiensis subsp. israelensis that contained different combinations of its Cry proteins and Cyt1Aa suggested that the latter protein delayed resistance. This hypothesis, however, has not been tested experimentally. Here we report experiments in which separate C. quinquefasciatus populations were selected for 20 generations to recombinant strains of B. thuringiensis that produced either Cyt1Aa, Cry11Aa, or a 1:3 mixture of these strains. At the end of selection, the resistance ratio was 1,237 in the Cry11Aa-selected population and 242 in the Cyt1Aa-selected population. The resistance ratio, however, was only 8 in the population selected with the 1:3 ratio of Cyt1Aa and Cry11Aa strains. When the resistant mosquito strain developed by selection to the Cyt1Aa-Cry11Aa combination was assayed against Cry11Aa after 48 generations, resistance to this protein was 9.3-fold. This indicates that in the presence of Cyt1Aa, resistance to Cry11Aa evolved, but at a much lower rate than when Cyt1Aa was absent. These results indicate that Cyt1Aa is the principal factor responsible for delaying the evolution and expression of resistance to mosquitocidal Cry proteins.
Languages in Contact (1979)

The appearance of Uriel Weinreich's Languages in Contact: Findings and Problems (1953) marked a milestone in the study of multilingualism and language contact. Yet until now, few linguists have been aware that its main themes were first laid out in Weinreich’s Columbia University doctoral dissertation of 1951, Research Problems in Bilingualism with Special Reference to Switzerland . Based on the author's fieldwork, it contains a detailed report on language contact in Switzerland in the first half of the 20th century, especially along the French-German linguistic border and between German and Romansh in the canton of Grisons (Graubünden). The present edition reproduces Weinreich's original text in full, with only minor alterations and corrections, as well as the author's fieldwork photographs and many of his hand-drawn diagrams. A new foreword reviews Weinreich's life and legacy, as well as developments in contact linguistics and the Swiss linguistic situation over the past 60 years. With selected comments on noteworthy points and references to more recent literature, this volume will be of interest not only to those working on the languages of Switzerland, or specialists in language contact, but all scholars today whose work builds on the broad and lasting foundations laid over half a century ago by Uriel Weinreich.
Transactivation of the Hepatitis B Virus Core Promoter by the Nuclear Receptor FXRα (2008)

Hepatitis B virus (HBV) core promoter activity is positively and negatively regulated by nuclear receptors, a superfamily of ligand-activated transcription factors, via cis-acting sequences located in the viral genome. In this study, we investigated the role of farnesoid X receptor alpha (FXRalpha) in modulating transcription from the HBV core promoter. FXRalpha is a liver-enriched nuclear receptor activated by bile acids recognizing hormone response elements by forming heterodimers with retinoid X receptor alpha (RXRalpha). Electrophoretic mobility shift assays demonstrated that FXRalpha-RXRalpha heterodimers can bind two motifs on the HBV enhancer II and core promoter regions, presenting high homology to the consensus (AGGTCA) inverted repeat FXRalpha response elements. In transient transfection of the human hepatoma cell line Huh-7, bile acids enhanced the activity of a luciferase reporter containing the HBV enhancer II and core promoter sequences through FXRalpha. Moreover, using a greater-than-genome-length HBV construct, we showed that FXRalpha also increased synthesis of the viral pregenomic RNA and DNA replication intermediates. The data strongly suggest that FXRalpha is another member of the nuclear receptor superfamily implicated in the regulation of HBV core promoter activity and that bile acids could play an important role in the natural history of HBV infection.
The Queen of SIMs [mobile phones] (2004)

The SIM (Subscriber Identity Module) transformed the smartcard business as mobile phones started to flourish and each had to carry one. But, as the networks become increasingly complex, offering a multiplicity of capabilities to the users-multimedia applications, high-performance processing, large storage and commerce-the complexity of the SIM grows, too. The USIM (Universal Subscriber Identity Module) will improve the relationship with the users and it's a good candidate to enable content delivery. The USIM is expected to offer higher capacities, going into the megabyte domain, to be able to store even more data to meet the growing number of applications in its pitch to be 'all things to all people'.
Adaptive fault tolerance and graceful degradation under dynamic hard real-time scheduling (2002)

Static redundancy allocation is inappropriate in hard real-time systems that operate in variable and dynamic environments, (e.g., radar tracking, avionics). Adaptive fault tolerance (AFT) can assure adequate reliability of critical modules, under temporal and resource constraints, by allocating just as much redundancy to less critical modules as can be afforded thus gracefully reducing their resource requirement. We propose a mechanism for supporting adaptive fault tolerance in a real-time system. Adaptation is achieved by choosing a suitable redundancy strategy for a dynamically arriving computation to assure required reliability and to maximize the potential for fault tolerance while ensuring that deadlines are met. The proposed approach is evaluated using a real-life workload simulating radar tracking software in AWACS early warning aircraft. The results demonstrate that our technique outperforms static fault tolerance strategies in terms of tasks meeting their timing constraints. Further, we show that the gain in this timing-centric performance metric does not reduce the fault tolerance of the executing task below a predefined minimum level. Overall, the evaluation indicates that the proposed ideas result in a system that dynamically provides QoS guarantees along the fault-tolerance dimension.