gebhart/patrepeval huggingface dataset:
Modulators of Intestinal Alkaline Phosphatase (2013)

Small molecule modulators of phosphatases can lead to clinically useful drugs and serve as invaluable tools to study functional roles of various phosphatases in vivo. Here, we describe lead discovery strategies for identification of inhibitors and activators of intestinal alkaline phosphatases. To identify isozyme-selective inhibitors and activators of the human and mouse intestinal alkaline phosphatases, ultrahigh throughput chemiluminescent assays, utilizing CDP-Star as a substrate, were developed for murine intestinal alkaline phosphatase (mIAP), human intestinal alkaline phosphatase (hIAP), human placental alkaline phosphatase (PLAP), and human tissue-nonspecific alkaline phosphatase (TNAP) isozymes. Using these 1,536-well assays, concurrent HTS screens of the MLSMR library of 323,000 compounds were conducted for human and mouse IAP isozymes monitoring both inhibition and activation. This parallel screening approach led to identification of a novel inhibitory scaffold selective for murine intestinal alkaline phosphatase. SAR efforts based on parallel testing of analogs against different AP isozymes generated a potent inhibitor of the murine IAP with IC50 of 540 nM, at least 65-fold selectivity against human TNAP, and >185 selectivity against human PLAP.
Carotid artery stenting simulation: From patient-specific images to finite element analysis (2010)

The outcome of carotid artery stenting (CAS) depends on a proper selection of patients and devices, requiring dedicated tools able to relate the device features with the target vessel. In the present study, we use finite element analysis to evaluate the performance of three self-expanding stent designs (laser-cut open-cell, laser-cut closed-cell, braided closed-cell) in a carotid artery (CA). We define six stent models considering the three designs in different sizes and configurations (i.e. straight and tapered), evaluating the stress induced in the vessel wall, the lumen gain and the vessel straightening in a patient-specific CA model based on computed angiography tomography (CTA) images. For the considered vascular anatomy and stents, the results suggest that: (i) the laser-cut closed-cell design provides a higher lumen gain; (ii) the impact of the stent configuration and of the stent oversizing is negligible with respect to the lumen gain and relevant with respect to the stress induced in the vessel wall; (iii) stent design, configuration and size have a limited impact on the vessel straightening. The presented numerical model represents a first step towards a quantitative assessment of the relation between a given carotid stent design and a given patient-specific CA anatomy.
Infrared Thermal Imaging: Fundamentals, Research and Applications (2010)

Fundamentals of Infrared Thermal Imaging Basic Properties of IR Imaging Systems Advanced Methods in IR Imaging Some Basic Concepts of Heat Transfer Basic Applications: Direct Visualization of Physics Phenomena IR Imaging of Buildings and Infrastructure Industrial Application: Detection of Gases Microsystems Selected Topics in Research and Industry (thermal reflections, metal industry, automobile industry, airplane and space craft industry, various industrial applications, electric applications) Miscellaneous: Selected Applications in Other Fields (medical and veterinary applications, sports, arts, surveillance and security, nature)
The effect of sodium valproate on serum cortisol levels in healthy subjects and depressed patients (1988)

In nine healthy subjects the i.v. injection of 800 mg of the GABA-transaminase inhibitor sodium valproate (SV) was able to suppress serum cortisol significantly when compared to saline. Three and a half hours after the administration of SV, serum cortisol was reduced to less than 50% of the basal value in each of the subjects. Among 17 depressed patients serum cortisol was reduced to less than 50% of basal value 3 1/2 h after SV in only two patients. No difference was found between nine patients with endogenous depression and eight with non-endogenous depression. The dexamethasone suppression test was abnormal in four out of 17 patients. These four patients had endogenous depression, and also an abnormal response to SV. A positive correlation was found between the effect of SV on serum cortisol, and age (r = 0.55), but not between the percentual decrease of serum cortisol and the severity of depression. The effect of SV on serum cortisol was significantly less pronounced in depressed patients than in controls but no difference was found between patients with endogenous and non-endogenous depression.
Simultaneous Assay for Four Bacterial Species Including Alloiococcus otitidis Using Multiplex-PCR in Children With Culture Negative Acute Otitis Media (2010)

Conventional culture detected otopathogens in MEF of children with a bulging TM in 71%; using multiplex-PCR, otopathogens were detected in 88% of MEF (P < 0.01). Similar improved detection of otopathogens was noted with nasopharyngeal and oropharyngeal cultures.
以多層次舒爾法在 CPU-GPU 叢集上解大型稀疏線性系統 (2014)

CPUs have reached their clock rate limits due to physical constrains. Parallel computers are increasingly used to achieve higher computing performances. How computational algorithms and codes can take advantages of parallel computers thus become more and more important. In scientific computing, solving large sparse general linear systems is one of critical problem. The nested dissection recording can reorder a sparse matrix to allow parallelism of triangular factorization on block sub-matrices. The key of this approach is how we solve embedded linear system corresponding to the Schur complement. While existed methods solve this embedded linear system iteratively, we carefully study the hierarchical of the Schur complement so that we can use direct methods to solve the embedded linear system recursively. We demonstrate the advantage of our approach by focusing on an implementation on CPU-GPU hybrid system for symmetric positive definite linear systems. Numerical results suggest the proposed hierarchical Schur method is promising in small or large parallel computer cluster with many-core accelerators.
New Synthesis Method of Ethanol from Dimethyl Ether with a Synergic Effect between the Zeolite Catalyst and Metallic Catalyst (2009)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNew Synthesis Method of Ethanol from Dimethyl Ether with a Synergic Effect between the Zeolite Catalyst and Metallic CatalystXiaoguang San†, Yi Zhang†, Wenjie Shen‡, and Noritatsu Tsubaki*†§View Author Information Department of Applied Chemistry, Graduate School of Engineering, University of Toyama, Gofuku 3190, Toyama City, Toyama 930-8555, Japan, State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China, and Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST), Sanbancho 5, Chiyoda-ku, Tokyo 102-0075, Japan* To whom correspondence should be addressed. Fax: (81)-76-445-6846. E-mail: [email protected]†University of Toyama.‡Chinese Academy of Sciences.§JST, CREST.Cite this: Energy Fuels 2009, 23, 5, 2843–2844Publication Date (Web):April 6, 2009Publication History Received29 January 2009Revised23 March 2009Published online6 April 2009Published inissue 21 May 2009https://doi.org/10.1021/ef900080gCopyright © 2009 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2351Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (45 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Catalysts,Ethanol,Organic compounds,Zeolites Get e-Alerts
A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. (1990)

We isolated a novel gene designated mak (male germ cell-associated kinase) by using weak cross-hybridization with a tyrosine kinase gene (v-ros). Sequence analysis of the cDNA corresponding to the 2.6-kilobase transcript revealed that the predicted product of rat mak consisted of 622 amino acids and contained protein kinase consensus motifs in its amino-terminal region. Comparison of the deduced amino acid sequence of mak in the kinase domain with those of other protein kinase genes demonstrated that mak was approximately 40% identical to the cdc2-CDC28 gene family in Schizosaccharomyces pombe, Saccharomyces cerevisiae, and humans but less identical to most other protein kinase gene products. Expression of mak was highly tissue specific, and its transcripts were detected almost exclusively in testicular cells entering and after meiosis but hardly detectable in ovarian cells including oocytes, after the dictyotene stage. These results suggest that the mak gene plays an important role in spermatogenesis.
Initial Study of Reconfigurable Neural Network Accelerators (2016)

Neural networks or NNs are widely used for many machine learning applications such as image processing and speech recognition. Since general-purpose processors such as CPUs and GPUs are energy inefficient for computing NNs, application-specific hardware accelerators for NNs (a.k.a. neural network accelerators or NNAs) have been proposed to improve the energy efficiency. However, existing NNAs are too customized for computing specific NNs, and do not allow to change NN models or learning algorithms. This limitation prevents machine-learning researchers from exploiting NNAs, so we are developing a general-purpose NNA that has the capability to compute any NN. Our NNA equips with reconfigurable logic in addition to various custom logics, which is called reconfigurable NNA or RNNA. RNNA is highly tuned for the NN computation but allows end users to customize the hardware to compute their desired NN. This paper introduces the RNNA architecture, and reports the performance analysis of RNNA with a cycle-level simulator.
中国“走出去”政策的挫折 (2009)

中铝注资195亿美元，未能成功收购澳大利亚力拓集团，是中国政府实施企业“走出去”政策的最惨痛失败。“走出去”战略失败主要问题在于国家和国有企业目标不一。中铝属政府控制，但该公司大多数业务收益是通过股市交易获得。从企业来说，195亿美元收购成功可在很大程度上缓解必和必拓和力拓合并带来的威胁。但从国家最佳利益来说，中国应采取行动，帮助力拓解决其资金困难问题，而不是增加中铝在力拓的所有权。尽管收购失败，但中国企业学会了如何走向全球。
The Effect of Ageing on Physical and Chemical Properties of Asphalt Cement (2008)

Two grades of paving asphalt with penetration of 46 and 65 are studied for determining changes in their physical and chemical properties caused by ageing.The ageing process has been conducted on two petroleum paving asphalt cement using thin film oven test at 150, 163 and 175 C, and ageing time 5, 10,15, 20, 25 and 30 hours. The effect of ageing time and temperature on penetration, kinematic viscosity, softening point, solubility in trichloroethylene, heat loss and changes in chemical composition are investigated. The results of thin film oven test process indicte that the asphaltenes concentration of all aged asphalt increases with increasing ageing time, while the opposite was observed for polar-aromatic and naphthene-aromatic. The saturate of low penetration grade asphalt is higher than that for high penetration grade asphalt and remained unchanged with ageing time. Th kinematic viscosity and softening point seem to increase with increasing ageing time, while the penetration decreases with increasing ageing time. The DI of aged asphalt inreases with increasing ageing time.
Phospholipids of palash (<i>Butea monosperma</i>), papaya (<i>Carica papaya</i>), jangli badam (<i>Sterculia foetida</i>), coriander (<i>Coriandrum sativum</i>) and carrot (<i>Daucus carota</i>) seeds (1987)

Abstract Analyses of the phospholipids of palash (Butea monosperma) , papaya (Carica papaya) , jangli badam (Sterculia foetida) , coriander (Coriandrum sativum) and carrot (Daucus carota) seeds are reported in the present study. Phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol were identified as major components in all the seeds. Small amounts of lysophosphatidylcholine in palash and papaya, and cardiolipin in palash, papaya and carrot also were detected. The predominant fatty acids present in the total and individual phospholipids of the seeds examined were oleic, linoleic and palmitic. In the case of palash and papaya phospholipids, the profile of fatty acid distribution was similar to that of their respective oils. However, the unusual fatty acids present predominantly in jangli badam, coriander and carrot oils were found to be significantly reduced in the respective phospholipids.
Performance benchmark results for automated tape library high retrieval rate applications. Digital check image retrievals (2003)

Benchmark tests have been designed and conducted for the purpose of evaluating the use of automated tape libraries in on-line digital check image retrieval applications. This type of application is representative of digital library applications requiring service to multiple concurrent users with service request response time identified as a very important metric. The benchmark test design was guided by a simplified theoretical queuing performance model developed to predict average response time as a function of request rate, object size retrieved, hardware characteristics, and library configuration. An exponential interarrival time distribution was used to simulate the multiple user environment, thus corresponding to an M/E/sub k//c queue. A series of nine benchmark test runs, each consisting of nominally 1000 retrievals, was conducted for average request rates of 50, 100, 150, 200, and 250 requests per hour and for library configurations varying from two to six drives. The resulting experimental response time distributions were analyzed by fitting the data to a Shifted Erlang distribution function and also by determining the time for which the response corresponded to cumulative percentiles ranging from 10% to 95%. Good agreement was obtained between the modelled and experimentally determined average response time. For the hardware and software systems used in these tests, an average response time of approximately 30 seconds has been achieved under conditions of Poisson arrivals at average rates up to approximately 150 requests per hour. The use of timing trace data has identified the potential for further response time improvements.
Synthesis and characterization of 5-[(4-azidophenacyl)thio]uridine 5'-triphosphate, a cleavable photo-cross-linking nucleotide analog (1989)

The synthesis, isolation, and characterization of a new photo-cross-linking uridine 5'-triphosphate analogue are described. This nucleotide analogue, 5-[(4-azidophenacyl)thio]uridine 5'-triphosphate (5-APAS-UTP), contains an aryl azide group approximately 10 A from the uridine ring. The azide is photoactivated by irradiation at 300 nm, resulting in covalent attachment of the nucleotide to adjacent molecules. The nucleotide can be desulfurated with Raney nickel to cause molecular cleavage between the base and the aryl azide. Desulfuration yields uridine 5'-triphosphate and p-azidoacetophenone. If the analogue is cross-linked to another molecule, desulfuration leaves the analogue's acetophenone group attached to that molecule. This effectively leaves behind a molecular tag on molecules that interact with the uridine analogue either as monomeric nucleotide or as part of an RNA molecule. This nucleotide analogue can be incorporated into internal positions in RNA by transcription in vitro with Escherichia coli RNA polymerase. It can therefore be used to examine interactions between RNA and other molecules (e.g., proteins or nucleic acids). Because the sulfur atom can be selectively removed, the covalent bonds formed between analogue-containing RNA and other molecules can be cleaved, when desired, to facilitate identification of the cross-linked molecules and RNA nucleotides in the cross-linked complex.
On test pattern compaction with multi-cycle and multi-observation scan test (2010)

This paper proposes a test compaction method for full scan circuits based on multiple capture clock cycles. The multiple cycle test applies more than one capture clock signals for a circuit after scan shift operation, while the capture clock cycle of the conventional scan test is one. Because every captured value at scan flip-flops is used for fault detection, the opportunity of fault detection for each fault increases. As a result, the number of test vectors would be decreased compared with the single cycle mode. Such a test compaction method would be useful in field test that requires less test data so as to store them on-chip. Experimental results show that the proposed method is effective for test compaction.
Modified Double-Flux-Quantum Amplifier for Bipolar Voltage Multiplication (2015)

Single-flux-quantum (SFQ) circuits can generate highly accurate average voltage. We have developed SFQ digital-to-analog converters (DACs) for application of new ac voltage standards. In this paper, we present a bipolar voltage amplifier (BVA) based on a double flux quantum amplifier (DFQA) for generation of intrinsic bipolar voltage in an SFQ-DAC. The BVA realizes the identical multiplication factors for the positive and negative output, whereas the conventional DFQA has different multiplication factors in the bipolar output. The BVA can be used for the output stage of the SFQ- DAC. We have designed a 19-fold BVA and confirmed that the 19-fold BVA operated for input frequency of up to 31.2 GHz in positive voltage output and 33.6 GHz in negative voltage output.
Follow-up Data of 10 Patients With B-cell Non-Hodgkin Lymphoma With a CD20-negative Phenotypic Change After Rituximab-containing Therapy (2013)

Recently, a CD20-negative phenotypic change in CD20-positive B-cell non-Hodgkin lymphoma (B-NHL) after rituximab therapy was described. We report the follow-up data of 10 B-NHL patients showing this change after rituximab therapy. Ten patients (4 men and 6 women; median age, 57 y) with B-NHL who were initially CD20 positive and became CD20 negative after rituximab therapy were analyzed. Clinicopathologic features, including clinical course, CD20 expression, and histopathology, were examined. CD20 expression in lymphoma cells was evaluated using immunohistochemistry and/or flow cytometry. Histopathologically, diagnosis at initial presentation was follicular lymphoma (FL) in 7 patients; diffuse large B-cell lymphoma in 1; and chronic lymphocytic leukemia in 2. Six patients (60%, 3 FL, 1 diffuse large B-cell lymphoma, and 2 chronic lymphocytic leukemia patients) showed continuous CD20 negativity until 24 months after the phenotypic change. Three patients (30%) with FL regained CD20 expression within 1 to 7 months after detection of the CD20 change. Two patients (20%) with FL, including 1 who regained CD20 expression, showed heterogenous CD20 expression with a CD20-negative low-grade component and a CD20-positive large cell component. The overall response rate to therapy before the CD20-negative change was 70%. We reported the follow-up data of 10 B-NHL patients with a CD20-negative phenotypic change associated with rituximab-containing therapy. The most common histologic phenotypes were continuous CD20 negativity, recovery of CD20 expression within 7 months, and heterogenous CD20 expression. As the changes in morphology and CD20 expression after rituximab therapy vary widely, careful follow-up and rebiopsy are recommended.
Work-in-Progress: Dynamic Data Management for Automotive ECUs with Hybrid RAM-NVM Memory (2018)

Non-Volatile Memory (NVM) can be utilized to improve performance of automotive electronic systems, but frequent writings on NVM will decrease its lifetime. In this paper, we propose a Vehicle Dynamic Data Management (VDDM) scheme, which can distinguish the hot or cold data generated by vehicle Electronic Control Units (ECUs) and sensors, and manage the data to reduce the writing operations on NVM of the hybrid main memory. Experimental results show that VDDM can significantly reduce writing operations and prolong lifetime of NVM compared with other approaches.
The Pruned N-Best Heuristic Search Algorithm (2000)

This paper presents a semi-optimal heuristic search algorithm called Pruned N-Best, which has both the search behavior of the N-Best heuristic search algorithm and the minimization of backtracking search to applying a pruning technique over certain search paths. This minimization increases the Pruned N-Best algorithm efficiency when compared with others semi-optimal algorithms. In domains where the number of operators grows up exponentially with the problem dimension the Pruned N-Best algorithm have been applied successfully (e.g. qualitative spatial reasoning area. Spatial reasoning planners usually tackle with problem models, where the interaction among elements is higher and change should be modeled not only taking the alteration of topological properties but also the creation, elimination and mutation of elements in the domain. As consequence, planners based on the search paradigm need special approaches to find out practical solutions. Even the N-Best search algorithm perhaps is inadequate to solve some practical problems specially those where the heuristic function is monotonic increasing (the condition for which the N-Best degenerates in the WA*). The Pruned N-Best search algorithm here presented does not share the previous critical characteristics and it is complete under certain search conditions and it is effective in a wide class of problems.