gebhart/patrepeval huggingface dataset:
Imaging and Analysis of Pseudomonas aeruginosa Swarming and Rhamnolipid Production (2011)

Many bacteria spread over surfaces by "swarming" in groups. A problem for scientists who study swarming is the acquisition of statistically significant data that distinguish two observations or detail the temporal patterns and two-dimensional heterogeneities that occur. It is currently difficult to quantify differences between observed swarm phenotypes. Here, we present a method for acquisition of temporal surface motility data using time-lapse fluorescence and bioluminescence imaging. We specifically demonstrate three applications of our technique with the bacterium Pseudomonas aeruginosa. First, we quantify the temporal distribution of P. aeruginosa cells tagged with green fluorescent protein (GFP) and the surfactant rhamnolipid stained with the lipid dye Nile red. Second, we distinguish swarming of P. aeruginosa and Salmonella enterica serovar Typhimurium in a coswarming experiment. Lastly, we quantify differences in swarming and rhamnolipid production of several P. aeruginosa strains. While the best swarming strains produced the most rhamnolipid on surfaces, planktonic culture rhamnolipid production did not correlate with surface growth rhamnolipid production.
Determination of 2´-5´-Oligoadenylate Synthetase in Serum and Peripheral Blood Mononuclear Cells before and after Subcutaneous Application of Recombinant Interferon beta and gamma (1992)

The interferon-inducible enzyme, 2'-5'-oligoadenylate synthetase, was estimated in healthy donors and in patients before and after subcutaneous application of recombinant interferon beta and gamma. Tests were carried out with lysates of peripheral blood mononuclear cells, using an established radioenzymatic assay, and in serum samples, using a new radioimmunoassay. Both test systems substantially yielded the same results: after a single injection of interferon beta (1-5 x 10(6) IU), 2'-5'-oligoadenylate synthetase increased in a dose-dependent manner reaching maximal catalytic concentrations in most patients after 24-48 hours (leukocytes) and 48-72 hours (serum). In contrast, interferon gamma (2-4 x 10(6) IU) caused only a small induction of 2'-5'-oligoadenylate synthetase. However, daily application of interferon gamma for 7 days led to a distinct time-dependent increase of 2'-5'-oligoadenylate synthetase activity concentration during this observation period. Characteristically, even during daily application, the 2'-5'-oligoadenylate synthetase activity concentration dropped just 48-72 hours after the first injection of interferon beta. The determination of 2'-5'-oligoadenylate synthetase proved to be useful for optimizing and monitoring subcutaneous therapy with interferon. The new radioimmunoassay which allows the determination of this enzyme in serum is superior to other methods used in the past.
Symmetric differential capacitive pressure sensor (1993)

Differential capacitive sensors are common to pressure gauges. Previous sensors of the bridge type have utilized only two variable (active) components, resulting in a half-bridge electrical equivalent circuit. There are numerous advantages of a symmetric full bridge, using four active components. The symmetry improves linearity and increases signal to noise ratio, especially when supported by electronics based on synchronous detection. Another advantage of symmetry is invariance to scaling, through immunity to stray capacitance. This feature is especially important in relationship to the current trend toward micro-electro-mechanical systems. A crude, inexpensive, macroscopic prototype of the present design was built with attention to high sensitivity. Constructed with a thin aluminized Mylar diaphragm, this device can readily resolve pressure changes smaller than 10−2 Pa.
Multiplication onset and electric field properties of proton irradiated LGADs (2018)

This work focuses on the study of a set of Low Gain Avalanche Detectors (LGADs) produced by CNM, Barcelona (run 7859). Several samples were irradiated with 24-GeV/c protons up to different fluences, ranging between 10$^{12}$ and 10$^{15}$ n$_\textrm{eq}$/cm$^2$. This study concentrates mainly on the LGADs irradiated up to 10$^{14}$ n$_\textrm{eq}$/cm$^2$. The measurements performed to characterise the devices include TCT, edge-TCT, TPA-TCT, and CV/IV measurements. The main goals of these studies were to analyse the voltage required to fully deplete the multiplication layer of LGADs; to measure gain degradation; and to investigate the distribution of the electric field inside the devices after irradiation, as well as the characteristics of the space charge. In order to do so, the measurements were performed under different temperature, read-out and biasing conditions. The obtained data confirm that in highly proton-irradiated LGADs the depletion of the bulk starts from the back electrode, thus shifting the onset of charge multiplication towards higher voltages. This is caused by a space charge sign inversion that is in turn accompanied by the appearance of a triple junction. Furthermore, it was found that annealing causes a recovery of gain along with a reduction of the multiplication-onset voltage towards unirradiated-like values.
Managing software defects (2008)

This paper describes a mechanism for presenting software defect metrics to aid analysis. A graphical representation of the history of software builds is presented, that records software build quality in a way that cannot be displayed in a single numerical table, and is visually more appealing and more easily digestible than a series of related tables. The radial analysis charts can be used to represent derivative information in a two-dimensional form and is demonstrated with practical examples of Defect Analysis and Root Cause Analysis.
Characteristics of methanogens isolated from bovine rumen (1986)

Six strains of methanogens were isolated from 10(-8) and 10(-9) ml of bovine rumen contents. All strains had the morphologic and physiologic characteristics of Methanobrevibacter spp. Four strains required coenzyme M; two did not. Growth of all strains either depended on or was stimulated by a mixture of isobutyric, isovaleric, 2-methylbutyric, and valeric acids. None of the strains reacted with antiserum against the type strain of Methanobrevibacter ruminantium.
Celiprolol stimulates endothelial nitric oxide synthase expression and improves myocardial remodeling in deoxycorticosterone acetate-salt hypertensive rats (2001)

Myocardial remodeling of DOCA-salt hypertensive rats was significantly ameliorated by subdepressor doses of celiprolol, which may be due to increased eNOS expression in the left ventricle.
Discrimination of Small Gas Molecules through Adsorption: Reverse Selectivity for Hydrogen in a Flexible Metal−Organic Framework (2009)

Zn(2+) ions react with 3,5-pyridinedicarboxylate (pydc) to form a new metal-organic framework (MOF), [Zn(pydc)(dma)] (dma = N,N'-dimethylacetamide), based on a noninterpenetrating (10,3)-a topology. The framework possessing narrow one-dimensional channels is highly flexible, and as a result, guest-dependent breakthrough-like adsorptions occur under atmospheric pressure. This "gate opening" requires strong interactions between gas molecules and the adsorbent, and therefore [Zn(pydc)(dma)] shows a reverse selectivity for H(2) at 77 K, which is very unusual in MOFs. At 195 K, only CO(2) is selectively adsorbed by this material because of the temperature dependence of the gated adsorption.
Planning for Successful Window Milling Operation (1998)

Abstract Historically, the applications of window milling tools and methods were limited to remedial operations. The main bore would be sidetracked only in the event of irretrievable fish, collapsed casing, depleted reservoir, etc. In recent years however, the re-entry drilling has become an increasingly popular option for production optimization as a result of advanced developments in the milling, drilling and measurement tools and technology. One of the important aspects of re-entry drilling is to mill a window in the existing casing and sidetrack the well bore. Past experience shows that inadequate planning for a window milling project has resulted in either an aborted attempt or premature failure in the hole. In order to achieve a successful window milling operation, the following ten (10) points must be addressed and situations resolved prior to commencing with the casing exit operation; (1) Selection of best place to set and to orient the whip-stock, (2) Hole angle, (3) Radius of curvature (build, drop, left or right tum) in the vicinity of casing exit, (4) Whip face orientation methods (MWD, gyros), (5) Flexure characteristics of the bottom hole assembly and resulting dogleg severity, (6) Length of sidetracking assembly, (7) Depth of rat hole to facilitate drilling objective (short, medium or long radius) after milling window, (8) Casing conditions, (9) Formation types, and (10) Retrievability of whip-stock assembly. This paper will discuss the above points in detail using data from actual field runs. The field runs will be selected from a large database of window milling jobs maintained over the last 10 years. Additionally, the paper will present recommendations and guidelines for planning a successful window-milling project.
Rare earth doped GaN electroluminescent devices (2004)

In this paper, we discuss the fabrication, operation and aplications of rare-earth-doped GaN electroluminescent devices (ELDs). GaN:RE ELDs. GaN:RE ELDs emit light due to impact excitation of the RE ions by hot carriers followed by radiative relaxation. By appropriately choosing the RE dopant, narrow line width emission can be obtained at selected wavelengths from the ultraviolet to the infrared. The deposition of GaN:RE layers is carried out primarily by MBE. GaN growth mechanism and optimization for RE emission are discussed based on RE concentration, growth temperature, and III-V ratio. We have investigated the optimum growth conditions of RE doped GaN phosphors.
Opiate Pharmacology and Relief of Pain (2014)

Opioids remain the mainstay of severe pain management in patients with cancer. The hallmark of pain management is individualization of therapy. Although almost all clinically used drugs act through mu opioid receptors, they display subtle but important differences pharmacologically. Furthermore, not all patients respond equally well to all drugs. Evidence suggests that these variable responses among patients have a biologic basis and are likely to involve both biased agonism and the many mu opioid receptor subtypes that have been cloned.
HP 필터를 적용한 환율 변동성 예측력에 대한 연구 (2014)

델타 헤징과 직접 연결된 미래 가격의 이차 차분의 합이 실현 변동성으로 정의될 수 있으며, Reuter는 내재 변동성 자료를 제공한다. 본고는 Hodrick and Prescott(HP) 필터를 적용해서 내재 변동성으로부터 추출된 추세 정보의 실현 변동성에 대한 예측력을 보았다. 내재 변동성의 예측력을 부정한 기존 우리나라 자본시장에 대한 실증분석 결과와 다르게 HP 필터를 통해 추세가 추출된 내재 변동성의 예측력이 단순 내재 변동성 및 과거 변동성보다 뛰어난 결과를 보였다. 반면 Beveridge and Nelson 분해를 이용한 추세는 예측력을 제고하지는 않았다. KIKO 옵션에 대해 서브 프라임 기간을 전후하여 예측 방법에 따른 델타 헤징이 수행되었는데, 변동성을 고정하는 경우 델타 헤징의 손실이 제일 크며, 변동성 변화를 반영하는 방법간 차이는 크지 않았다. 따라서 헤징의 성과는 가격의 방향성에 강한 영향을 받는 것으로 보인다.
The role of angiotensin converting enzyme 2 in the generation of angiotensin 1–7 by rat proximal tubules (2004)

ANG converting enzyme (ACE) 2 (ACE2) is a homologue of ACE, which is not blocked by conventional ACE inhibitors. ACE2 converts ANG 1-10 (ANG I) to ANG 1-9, which can be hydrolyzed by ACE to form the biologically active peptide ANG 1-7. ACE2 is expressed in the kidney, but its precise intrarenal localization is unclear, and the role of intrarenal ACE2 in the production of ANG 1-7 is unknown. The present studies determined the relative distribution of ACE2 in the rat kidney and defined its role in the generation of ANG 1-7 in proximal tubule. In microdissected rat nephron segments, semiquantitative RT-PCR revealed that ACE2 mRNA was widely expressed, with relatively high levels in proximal straight tubule (PST). Immunohistochemistry demonstrated ACE2 protein in tubular segments, glomeruli, and endothelial cells. Utilizing mass spectrometry, incubation of isolated PSTs with ANG I (10(-6) M) led to generation of ANG 1-7 (sensitivity of detection > 1 x 10(-9) M), accompanied by the formation of ANG 1-8 (ANG II) and ANG 1-9. The ACE2 inhibitor DX600 completely blocked ANG I-mediated generation of ANG 1-7. Incubation of PSTs with ANG 1-9 also led to generation of ANG 1-7, an effect blocked by the ACE inhibitor captopril or enalaprilat, but not by DX600. Incubation of PSTs with ANG II or luminal perfusion of ANG II did not result in detection of ANG 1-7. The results indicate that ACE2 is widely expressed in rat nephron segments and contributes to the production of ANG 1-7 from ANG I in PST. ANG II may not be a major substrate for ACE2 in isolated PST. The data suggest that ACE2-mediated production of ANG 1-7 represents an important component of the proximal tubular renin-ANG system.
Inhibitors of bacterial adherence to urothelium. (1980)

We attempted to change the degree of bacterial adherence to rat urothelium by administering chemical and immunotropic agents as subcutaneous injections and as bladder instillations. Organic iodine instillations with an adjusted pH were effective. Levamisole and Freund adjuvant instillations were effective but were associated with excessive morbidity. AgNO3, inorganic iodide, and heparin instillations were not effective in the animal model used. Bladder instillations might be developed as a way to augment the antiadherence capacity of the bladder and prevent recurrent urinary tract infections.
DANTE: A Framework for Mining and Monitoring Darknet Traffic (2020)

Trillions of network packets are sent over the Internet to destinations which do not exist. This 'darknet' traffic captures the activity of botnets and other malicious campaigns aiming to discover and compromise devices around the world. In order to mine threat intelligence from this data, one must be able to handle large streams of logs and represent the traffic patterns in a meaningful way. However, by observing how network ports (services) are used, it is possible to capture the intent of each transmission. In this paper, we present DANTE: a framework and algorithm for mining darknet traffic. DANTE learns the meaning of targeted network ports by applying Word2Vec to observed port sequences. Then, when a host sends a new sequence, DANTE represents the transmission as the average embedding of the ports found that sequence. Finally, DANTE uses a novel and incremental time-series cluster tracking algorithm on observed sequences to detect recurring behaviors and new emerging threats. To evaluate the system, we ran DANTE on a full year of darknet traffic (over three Tera-Bytes) collected by the largest telecommunications provider in Europe, Deutsche Telekom and analyzed the results. DANTE discovered 1,177 new emerging threats and was able to track malicious campaigns over time. We also compared DANTE to the current best approach and found DANTE to be more practical and effective at detecting darknet traffic patterns.
Analysis of the alternatives for stereo multiplex in 3DTV broadcast delivery (2011)

Although 3DTV has led the evolution of television market, its delivery by broadcast networks is still small. Now, 3DTV transmissions are usually done by combining both views into one common frame (side by side) to be able to use standard HDTV transmission equipment. Today, orthogonal subsampling is mostly used, but other alternatives will appear soon. Here, different subsampling schemes for both progressive and interlaced 3DTV are considered. For each possible scheme, its preserved frequency content is analyzed and a simple interpolation filter is designed. The analysis is carried out for progressive and interlaced video and the designed filters are applied on different sequences, showing the advantages and disadvantages of the different options.
An intelligent robot vision system for research applications (2005)

This paper presents a Lisp-based robot vision system designed for research. It combines a Puma 560 robot arm, the computing power of a VAX 11/780 and a Grinnell Systems 275, the facility for artificial intelligence through Lisp, and sensing capability through a wrist-mounted camera. A description of the robot vision system includes system and software structure, the Lisp primitives for robot control, two vision algorithms, and a frame-based motion planner written in Lisp.
Cytotoxicity of a series of water-soluble mixed valent diruthenium tetracarboxylates. (2002)

The antineoplastic activity of the highly water-soluble m-sulpho derivative was the highest, while the poorly water-soluble imidazole derivatives did not exhibit any cytotoxic properties. The CoLo 320DM cancer cells were 5 times more prone to drug-induced cell death than the HeLa cells.
Oriented Protein Immobilization using Covalent and Noncovalent Chemistry on a Thiol-Reactive Self-Reporting Surface (2013)

We report the fabrication of a patterned protein array using three orthogonal methods of immobilization that are detected exploiting a fluorogenic surface. Upon reaction of thiols, the fluorogenic tether reports the bond formation by an instantaneous rise in (blue) fluorescence intensity providing a means to visualize the immobilization even of nonfluorescent biomolecules. First, the covalent, oriented immobilization of a visible fluorescent protein (TFP) modified to display a single cysteine residue was detected. Colocalization of the fluorescence of the immobilized TFP and the fluorogenic group provided a direct tool to distinguish covalent bond formation from physisorption of proteins. Subsequent orthogonal immobilization of thiol-functionalized biomolecules could be conveniently detected by fluorescence microscopy using the fluorogenic surface. A thiol-modified nitrilotriacetate ligand was immobilized for binding of hexahistidine-tagged red-fluorescing TagRFP, while an appropriately modified biotin was immobilized for binding of Cy5-labeled streptavidin.
&#x201C;Direction&#x201D; assisted Geographic Routing for mobile ad hoc networks (2008)

In Geographic Routing protocols (e.g. GPSR), a node makes packet forwarding decisions based on the coordinates of its neighbors and the packet’s destination. Geo-routing uses greedy forwarding as a default; if this fails (e.g. the packet is trapped in a dead end caused by holes and/or obstacles), a recovery scheme based on perimeter routing is invoked. This however often leads to degraded performance. In this paper, we present a hybrid routing scheme called Geographic Direction Forwarding Routing (Geo-DFR), which features efficient recovery from dead ends. Geo-DFR integrates on demand, table driven routing with geo-routing. During the data transfer, periodic routing advertisements from the destination help to track node motion and to update/maintain a feasible direction to the destination. Direction Forwarding in Geo-DFR is designed to complement and even replace perimeter routing in dead end recovery. With the help of a local coordinate system (e.g., GPS or virtual coordinate system), a node derives the direction of the arrival of the advertisements. A packet is first forwarded to the neighbor which yields the most progress towards the destination, i.e., greedy forwarding. If greedy forwarding fails, the packet is “directionally” forwarded to the “most promising” node along the advertised direction, i.e., direction forwarding. Moreover, the direction can be used proactively for “early dead end detection” to decide which forwarding scheme should be used to avoid getting stuck, which is opposed to GPSR in which perimeter routing is applied only after greedy forwarding fails. Through simulation experiments we show that Geo-DFR substantially improves the performance in large, mobile network scenarios.
Quality Hybrid Education Evaluation: Academic Staff Performance Assessment (Cases: Borys Grinchenko Kyiv University and the University of Silesia) (2017)

Abstract The process of adjusting transformation of education to dynamics of civilization development requires from systems of education to respond to constant corrections from all the stakeholders, agents and processes to upgrade its elements and parameters, which can be facilitated by real-time feedbacks at all levels of systems. Studying quality education in the context of the goals that the mankind has been setting for its sustainable development helps realize the changes in the attributes of educational system and subsystem elements, given quality of education reflects a level of disorder providing objective data on interactions of system elements and their discord with normative goals forecast for certain educational systems. The paper analyzes hybrid education as a form of education which is being determined by transformation of educational systems under applying ICTs for educational processes and by external factors connected with determining sustainable development and with hybridization of environment, which requires new instruments for quality assessment that are currently being under development.
18F-FDG PET reduces unnecessary hemithyroidectomies for thyroid nodules with inconclusive cytologic results. (2006)

In addition to data in the literature demonstrating accurate detection of thyroid cancer by (18)F-FDG PET, this study showed that (18)F-FDG PET should play an important role in the management of patients with inconclusive cytologic diagnosis of a thyroid nodule. (18)F-FDG PET reduced the number of futile hemithyroidectomies by 66%. Although PET is a relatively costly procedure, this cost outweighs the costs and risks associated with unnecessary thyroid surgery.
The therapeutic efficacy of ibandronate on metastatic bone pain (2006)

Objective To evaluate the therapeutic effect of treatment with intravenous(Ⅳ) ibandronate on bone pain in patients with skeletal metastases.Methods 36 patients with metastatic bone pain received Ⅳ ibandroante 4mg infused over 2 hours every 4 weeks.The therapeutic efficacy was evaluated after three circles.Results Before the treatment the mean bone pain score was 6.47±2.26,after intravenous Ⅳ ibandronate the mean bone pain score was 3.19±2.04,the difference was significant(t=10.397,P(0.01)).The response rate of pain was 72.2%.The treatment with Ⅳ ibandronate significantly improved quality of life of patients compare with baseline(P0.01).There were no evidence of liver,renal toxicity.Conclusion The treatment with Ⅳ ibandronate has a marked analgesic effect in patients with bone pain from metastatic bone disease and improve quality of life of patients.
Robust Autonomous Navigation of Unmanned Aerial Vehicles (UAVs) for Warehouses’ Inventory Application (2019)

The inventory inspection using autonomous unmanned aerial vehicles (UAVs) is beneficial in terms of cost, time, and safety of human workers. However, in typical warehouses, it is very challenging for the autonomous UAVs to do inventory task motions safely because aisles are narrow and long, and the illumination is poor. Prior autonomous UAVs are not suitable for such environments, since they suffer from either localization methods prone to disturbance, drift and outliers, or expensive sensors. We present a low-cost sensing system with an extended Kalman filter (EKF)-based multi-sensor fusion framework to achieve practical autonomous navigation of UAVs in warehouse environments. To overcome the inherent drift, outliers, and disturbance problems of naïve UAV localization methods, we suggest 1) exploiting component test of Mahalanobis norm to reject outliers efficiently, 2) introducing pseudo-covariance to incorporate a visual SLAM algorithm, and 3) recognizing floor lanes to get absolute information–as robust data fusion methods. Exemplar results are provided to demonstrate the effectiveness of the methods. The proposed system has been successfully implemented for diverse cyclic inventory inspection tasks in a materials warehouse.