gebhart/patrepeval huggingface dataset:
Head automata for speech translation (1996)

This paper presents statistical language and translation models based on collections of small finite state machines we call "head automata".The models are intended to capture the lexical sensitivity of N-gram models and direct statistical translation models, while at the same time taking account of the hierarchical phrasal structure of language.Two types of head automata are defined: relational head automata suitable for translation by transfer of dependency trees, and head transducers suitable for direct recursive lexical translation.
Development strategies of an intelligent human-machine interface for next generation nuclear power plants (1996)

An intelligent human-machine interface (HMI) has been developed to enhance the safety and availability of a nuclear power plant (NPP) by improving operational reliability. The key elements of the proposed HMI are the large display panels that present synopsis of the plant status and the compact, digital workstations for monitoring, control, and protection functions: The workstation consists of four consoles such as a dynamic alarm console (DAC), a system information console (SIC), a computerized operating-procedure console (COC), and a safety-related information console (SRIC). The DAC provides clean alarm pictures in which information overlapping is excluded and alarm impacts are discriminated for quick situation awareness. The SIC supports a normal operation by offering all necessary system information and control functions. In addition, it is closely linked to automatically display the related system information according to situations of the DAC and the COC. The COC aids the operator with proper emergency operation guidelines so as to shutdown the plant safely, and it also reduces his physical/mental burden by tracing the operating procedures automatically. The SRIC continuously displays safety-related information so that the operator can assess the plant status focusing on plant safety. The proposed HMI has been validated and demonstrated using the full-scope simulator for Yonggwang Units 1, 2. From the demonstration results, it can be concluded that the HMI enables the operator to terminate or mitigate plant disturbances early. After sufficient validation, the characteristic design features of the proposed HMI will be reflected in the main control room for the Korean next generation NPP's.
Ultrasonic method and apparatus for imaging and characterization of bodies using amplitude and polarity detection (1984)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Irwin Beretsky, David E. Arnold, Bruce Pellagrini; Ultrasonic method and apparatus for imaging and characterization of bodies using amplitude and polarity detection. J. Acoust. Soc. Am. 1 May 1984; 75 (5): 1665. https://doi.org/10.1121/1.390839 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes. (1991)

Peripheral blood monocytes can be induced by stimuli such as bacterial lipopolysaccharide (LPS) to secrete an array of cytokines. We have studied the effects of interleukin 7 (IL-7) on human peripheral blood mononuclear cells (PBMC) and found that IL-7 is a relatively potent inducer of IL-6 secretion IL-6 protein levels were determined either by the B9 hybridoma growth factor assay or by enzyme-linked immunosorbent assay, and mRNA for IL-6 was analyzed by Northern hybridization. Detailed examination revealed that, among PBMC, monocytes, rather than lymphocytes, were secreting IL-6 in response to IL-7. In contrast to the low concentrations of IL-7 required to stimulate T cell growth and differentiation (as low as 0.1 ng/ml), relatively high concentrations of IL-7 were necessary to induce IL-6 secretion by monocytes (at least 10 ng/ml). An optimal concentration of IL-7 (100 ng/ml) induced monocytes to secrete 10-fold more IL-6 than an optimal concentration of IL-1 beta (10 ng/ml), and almost as much as LPS. However, significantly more IL-7 than IL-1 beta was required to induce detectable levels of IL-6. The kinetics of IL-6 secretion by monocytes were identical in response to IL-7, IL-1 beta, or LPS, with IL-6 protein detectable in culture supernatants as early as 2 h after the initiation of culture. IL-4 was found to markedly inhibit the ability of IL-7 or LPS to induce IL-6 mRNA and IL-6 secretion. In addition to promoting IL-6 production, IL-7 induced the secretion of immunoreactive IL-1 alpha, IL-1 beta, and tumor necrosis factor alpha (TNF-alpha) by monocytes. IL-7 also induced monocyte/macrophage tumoricidal activity against a human melanoma cell target, an activity that may be related to the secretion of IL-1 alpha, IL-1 beta, and TNF-alpha. Finally, we used a whole blood culture system as a bridge to in vivo analysis to demonstrate that IL-7 induces cytokine secretion in the absence of culture medium, fetal calf serum, and adherence to plastic. Our data suggest that IL-7, in addition to regulating lymphocyte growth and differentiation, has potent effects on cells of the monocytic lineage. Thus, IL-7 may be an important mediator in inflammation and in the macrophage immune response to tumors.
Asteroid Detection and Monitoring Using a Satellite-Borne Visible Scanner (1993)

A satellite-borne visible scanner is proposed to continuously monitor the celestial sphere for near Earth asteroids. The proposed scanner uses the parallax motion of near Earth objects against a fixed background of distant objects. Image processing techniques will allow the detection of asteroids as small as 50 m in diameter at distances greater than 7 x 500,000 km. This will give sufficient warning time against Earth intersecting asteroids.
Nuclear Hormone Receptors Activate Direct, Inverted, and Everted Repeatsa (1995)

Nuclear hormone receptors comprise a family of ligand-modulated transcription factors that link cellular responses to extracellular and intracellular signals. Receptors for retinoids, thyroid hormone, vitamin D3 and fatty acids/peroxisome proliferators bind their response elements as heterodimers with the retinoid X receptor. Naturally occurring response elements are composed of core-motifs that are organized as direct, inverted, and/or everted repeats. The structural mechanisms that facilitate binding of a single receptor heterodimer to such diverse binding sites remain unknown.
Terahertz-wave parametric generation and detection system covering the range from 1 to 3 THz (2013)

We report on a terahertz-wave generation and detection system based on nonlinear parametric conversion. Tunable terahertz-waves are generated by high peak power, narrowband injection-seeded terahertz-wave parametric generator, and then, detected by frequency up-conversion in a nonlinear MgO:LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> crystal.
Fast high power capacitive RF-MEMS switch for X-Band applications (2015)

This paper presents a thin film metallic membrane (∼1μm) capacitive RF-MEMS shunt switch with a power handling of more than 20 W for X-Band applications. The device switching time is below 15 μs, in cold switching, for a 60 V applied voltage. The up-state capacitance is 40 fF, resulting in a less than 0.1 dB insertion losses at 10 GHz, simulated. The down-state capacitance, estimated at 3.1 pF, including the parasitic air capacitance from the surface roughness, results in a 77 capacitance ration for about 30 dB isolation, simulated. Measurements show up to a million cycles with no degradation on performances under 20W incident power in cold switching.
Downlink overhead reduction for Multi-Cell Cooperative Processing enabled wireless networks (2008)

Multicell cooperative processing (MCP) has been recognised as an efficient technique for increasing spectral efficiency of future cellular systems. However the provided benefits come at the cost of increased overhead and computational complexity; Mobile Stations (MSs) need to feed back to their assigned Base Station (BS) their local channel state information (CSI) which in turn needs to be transmitted to the Control Unit that coordinates the cooperating BSs. Furthermore user data needs to be routed to and from all cooperating BSs on the downlink and uplink respectively. Therefore in order for the overhead to be affordable, it is admitted that cooperating BSs shall be organised in clusters of a limited size. Nevertheless, it is still crucial that CSI feedback and inter-base information exchange be reduced. In this paper linear precoding is considered with the target of overhead minimisation of the downlink. A novel technique is proposed which allows MSs not to feed back the channel coefficients related to the cluster BSs that provide weak channel quality. This is shown to provide a good trade-off between performance and overhead.
A novel software defined radio relay method for power conservation (2016)

To meet beyond line of sight (BLOS) communications requirements, a novel software defined radio relay method for power conservation is proposed. This method is able to achieve approximately 7.5 watt per relay node power savings for SNR challenged links (probability = 1/3), adjacent interference links (probability = 1/3), and 33% clear links (probability = 1/3). This is accomplished by dynamically adjusting the relay methodology between a low power amplify-and-forward (AF) relay method, a compress-and-forward (CF) relay method, and a power intensive decode-and-forward (DF) relay method. To demonstrate the novel architecture the following models were developed in MATLAB/Simulink and tested on an Avnet Zynq-7000 software defined radio (SDR) with Military RT 1439A radios: an audio FM transmitter model, an audio FM receiver model, an AF relay model, a CF relay model, a DF relay model, and the novel SDR relay model.
Nanopore Stochastic Detection: Diversity, Sensitivity, and Beyond (2013)

Nanopore sensors have emerged as a label-free and amplification-free technique for measuring single molecules. First proposed in the mid-1990s, nanopore detection takes advantage of the ionic current modulations produced by the passage of target analytes through a single nanopore at a fixed applied potential. Over the last 15 years, these nanoscale pores have been used to sequence DNA, to study covalent and non-covalent bonding interactions, to investigate biomolecular folding and unfolding, and for other applications. A major issue in the application of nanopore sensors is the rapid transport of target analyte molecules through the nanopore. Current recording techniques do not always accurately detect these rapid events. Therefore, researchers have looked for methods that slow molecular and ionic transport. Thus far, several strategies can improve the resolution and sensitivity of nanopore sensors including variation of the experimental conditions, use of a host compound, and modification of the analyte molecule and the nanopore sensor. In this Account, we highlight our recent research efforts that have focused on applications of nanopore sensors including the differentiation of chiral molecules, the study of enzyme kinetics, and the determination of sample purity and composition. Then we summarize our efforts to regulate molecular transport. We show that the introduction of various surface functional groups such as hydrophobic, aromatic, positively charged, and negatively charged residues in the nanopore interior, an increase in the ionic strength of the electrolyte solution, and the use of ionic liquid solutions as the electrolyte instead of inorganic salts may improve the resolution and sensitivity of nanopore stochastic sensors. Our experiments also demonstrate that the introduction of multiple functional groups into a single nanopore and the development of a pattern-recognition nanopore sensor array could further enhance sensor resolution. Although we have demonstrated the feasibility of nanopore sensors for various applications, challenges remain before nanopore sensing is deployed for routine use in applications such as medical diagnosis, homeland security, pharmaceutical screening, and environmental monitoring.
Development of single-molecule tunnel-current based nucleotide identification method (2014)

We developed a tunnel-current based identification method of DNA / RNA sequence. This methodology is based on tunneling-current time-traces during its translocation of molecules through a nano-gap-electrode. We performed electrical measurements of DNA / RNA nucleotide translocating between gold nanogap-electrode separated by a sub-nanometer gap. Based on this determined electrical conductivity for single-nucleotides, we electrically identify the base-type in oligonucleotides, This method could be a promising small RNA profiling strategy.
Parametric Investigations of Miniaturized Cylindrical and Annular Hall Thrusters (2001)

A cylindrical geometry Hall thruster may overcome certain physical and technological limitations in scaling down of Hall thrusters to miniature sizes. The absence of the inner wall and use of the cusp magnetic field can potentially reduce heating of the thruster parts and erosion of the channel. A 2.6 cm miniaturized Hall thruster of a flexible design was built and successfully operated in the power range of 50-300 W. Comparison of preliminary results obtained for cylindrical and annular thruster configurations is presented.
Three Novel Alternative Splicing Mutations in BCR-ABL1 detected in CML Patients with Resistance to Kinase Inhibitors. (2009)

Abstract Abstract 1107 Poster Board I-129 The BCR-ABL1 tyrosine kinase is the target for kinase inhibitors in patients with chronic myeloid leukemia (CML). Multiple types of mutations in the BCR-ABL1 kinase domain have been reported. We previously reported a common alternatively spliced BCR-ABL mRNA with a 35-nucleotide insertion (35INS) between ABL1 kinase domain exons 8 and 9 that is expressed at various levels in CML patients with resistance to kinase inhibitors. Here we report 3 novel alternative splicing mutants expressed as the dominant transcripts in patient with CML and resistance to kinase inhibitors. We initially screened for ABL1 kinase domain mutations in approximately 200 patients with resistance to more than one of the three kinase inhibitors (imatinib, nilotinib, or dasatinib). Screening was conducted by first amplifying the fusion BCR-ABL1 transcript, to ensure that normal ABL1 was not amplified, then sequencing the ABL1 kinase domain coding region. We discovered 3 not previously described splice mutants, present in one patient each. All 3 showed >90% mutant transcript. The first resulted from the insertion of 79 nucleotides into the ABL1 exon 8-9 junction. The inserted sequence in fact contained a sequence from regions of intron 8, located 120 bp apart: the 35-nucleotide sequence previously described, and an additional 44-nucleotide segment downstream from 35INS. The combined 79-nucleotide insertion splice mutant showed the same protein change as 35INS (p C475YfsX11). The second splice mutation comprised an 84-nucleotide sequence from intron 7 inserted into the ABL1 exon7-8 junction, also causing a frameshift and protein truncation (p A424EfsX18). The third splice derived from a 231–nucleotide sequence from intron 4 retained in the ABL1 exon 4-5 junction. This insertion added 40 intron-encoded amino acids after K274, leading to a frameshift and early termination of BCR-ABL1 in the p-loop (p E275LfsX41). Exposure to kinase inhibitors may lead to the expression of alternatively spliced mRNA that is significantly elongated but causes a truncated fusion BCR-ABL1 that confers resistance to kinase inhibitors. These findings, when combined with the data on 35INS, support the concept that loss of the C-terminus of BCR-ABL1 is associated with significant resistance to kinase inhibitors; this mechanism appears to be a major source of resistance to kinase inhibitors. Disclosures No relevant conflicts of interest to declare.
Overnight Closed-Loop Insulin Delivery with Model Predictive Control: Assessment of Hypoglycemia and Hyperglycemia Risk Using Simulation Studies (2009)

The incidence of severe and significant hypoglycemia reduced 2300- and 200-fold, respectively, during stimulated overnight closed loop with MPC compared to that observed during open-loop overnight clinical studies in young subjects with T1DM. Hyperglycemia was 200 times less likely. Overnight closed loop with the FSN and the MPC algorithm is expected to reduce substantially the risk of hypoglycemia and hyperglycemia.
Electronic stringed instrument with fingering operating data memory system and navigate display device (1992)

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DeepCodec: Adaptive sensing and recovery via deep convolutional neural networks (2017)

We develop a novel computational sensing framework for sensing and recovering structured signals. When trained on a set of representative signals, our framework learns to take undersampled measurements and recover signals from these measurements using a deep convolutional neural network. In other words, it learns a transformation from the original signals to a near-optimal number of undersampled measurements and the inverse transformation from measurements to signals. This is in contrast to conventional compressive sensing (CS) systems that use random linear measurements and convex optimization or iterative algorithms for signal recovery.
Attenuation Pole Frequency Control of a Dual-Mode Circular Microstrip Ring Resonator BPF (1999)

A novel method is proposed to control the attenuation pole frequency of a dual-mode circular microstrip ring resonator bandpass filter, keeping the bandwidth constant. Here the coupling between the dual-modes is provided as the total effect of stub perturbation at the end of symmetry plane, and the angle between IO ports. By making a various combinations of these two parameters it is possible to control the attenuation pole frequency. An additional small coupling induced by excitation capacitance is also considered. Filters are simulated using the calculated coupling constant, and then the attenuation pole frequencies and bandwidth of the simulated filters are verified by experiment. Theoretical expressions are further devised to calculate the attenuation pole frequencies.
Multicast Scheduling in Cellular Data Networks (2007)

Multicast is an efficient means of transmitting the same content to multiple receivers while minimizing network resource usage. Applications that can benefit from multicast such as multimedia streaming and download, are now being deployed over 3G wireless data networks. Existing multicast schemes transmit data at a fixed rate that can accommodate the farthest located users in a cell. However, users belonging to the same multicast group can have widely different channel conditions. Thus existing schemes are too conservative by limiting the throughput of users close to the base station. We propose two proportional fair multicast scheduling algorithms that can adapt to dynamic channel states in cellular data networks that use time division multiplexing: Inter-group Proportional Fairness (IPF) and multicast proportional fairness (MPF). These scheduling algorithms take into account (1) reported data rate requests from users which dynamically change to match their link states to the base station, and (2) the average received throughput of each user inside its cell. This information is used by the base station to select an appropriate data rate for each group. We prove that IPF and MPF achieve proportional fairness among groups and among all users in a group inside a cell respectively. Through extensive packet-level simulations, we demonstrate that these algorithms achieve good balance between throughput and fairness among users and groups.
Unique Technology for Solubilization and Delivery of Highly Lipophilic Bioactive Molecules (2004)

We have produced a family of novel carriers enabling water solubilization of highly lipophilic molecules. The compound carriers were synthesized by conjugating polyethylene glycol to alpha-tocopherol, tocotrienols, beta-sitosterol or cholesterol via an alkanedioyl linker. These PEG- conjugates were amphiphilic and formed stable non-covalent complexes (nanomicelles) with a wide range of molecules including vitamins, carotenoids, ubiquinones, poly-unsaturated fatty acids and polyene macrolide antibiotics. The resulting formulations were water-soluble, non-toxic and had excellent stability. This solubilization method represents a major advance in the delivery of lipophilic molecules and could be used to reformulate drugs with near term patent expiry or those that have failed clinical trials due to low solubility. Furthermore, the technology could also be applied for delivery of active ingredients for dietary supplement, functional food, cosmetic and animal health industries.
An Improved DCT-Based OFDM Data Transmission Scheme (2006)

A discrete cosine transform (DCT)-based orthogonal frequency-division multiplexing (OFDM) system is described. The performance of the DCT-OFDM system with a zero-padding guard interval scheme and a minimum mean-square error (MMSE) receiver over time-varying multipath Rayleigh fading channels is investigated. The results show that employing the proposed DCT-OFDM system rather than the conventional DFT-OFDM system can provide better bit error rate performance in practical systems, by as much as 5.5 dB in signal-to-noise ratio (SNR).
Low-power area-efficient large-scale IP lookup engine based on binary-weighted clustered networks (2013)

We propose a novel architecture for low-power area-efficient large-scale IP lookup engines. The proposed architecture greatly increases memory efficiency by storing associations between IP addresses and their output rules instead of storing these data themselves. The rules can be determined by simple hardware using a few associations read from SRAMs, eliminating a power-hungry search of input addresses in TCAMs. The proposed hardware that stores 100,000 144-bit entries is evaluated under TSMC 65nm CMOS technology. The dynamic power dissipation and the area of the proposed hardware are 4.6% and 30.6% of a traditional TCAM, respectively while maintaining comparable throughput.
Impact of the seismic 'While Drilling' technique on exploration wells (1996)

Vertical seismic profiles (VSPs) are an extremely effective seismic $tool for surveying the area around a well. Conventional surveying techniques in which drilling is interrupted and a geophone is conveyed downhole, imply high costs and serious operating risks. Passive listening at the surface, which uses the noise produced by the bit during drilling as a seismic source for producing reciprocal VSPs, helps to overcome these difficulties.