gebhart/patrepeval huggingface dataset:
Lateral Control Implementation for an Unmanned Aerial Vehicle (2013)

This paper presents practical aspects of guidance and control design for UAV and its flight test results. The paper focuses on the lateral-directional control and guidance aspects. An introduction to the mission and guidance problem is given first. Waypoints for straight and turning flight paths are defined. Computation of various flight path parameters is discussed, including formulae for real-time calculation of down-range (distance travelled along the desired track), cross-track deviation, and heading error of the vehicle; these are then used in the lateral guidance algorithm. The same section also describes how to make various mission-related decisions online during flight, such as when to start turning and when a waypoint is achieved. The lateral guidance law is then presented, followed by the design of a robust multivariable <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mi>H</mml:mi><mml:mi>∞</mml:mi></mml:msub></mml:mrow></mml:math> controller for roll control and stability augmentation. The controller uses the ailerons and rudder for control of roll angle and stabilization of yaw rate of the vehicle. The reference roll angle is generated by the nonlinear guidance law. The sensors available on-board the vehicle do not measure yaw rate; hence, a practical method of its estimation is proposed. The entire guidance and control scheme is implemented on the flight control computer of the actual aerial vehicle and taken to flight. Flight test results for different mission profiles are presented and discussed.
Chemoprevention by isothiocyanates (1995)

Naturally occurring and synthetic isothiocyanates are among the most effective chemopreventive agents known. A wide variety of isothiocyanates prevents cancer in the rat lung, mammary gland, esophagus, liver, small intestine, colon, and bladder. Mechanistic studies have shown that this chemopreventive activity is due to favorable modification of phase I and phase II carcinogen metabolism, resulting in increased carcinogen excretion or detoxification and decreased carcinogen DNA interactions. Most studies reported that the isothiocyanate must be present at carcinogen exposure in order to effect tumorigenesis inhibition. Our studies focus on naturally occurring isothiocyanates phenethyl isothiocyanate (PEITC) and benzyl isothiocyanate (BITC) as lung cancer inhibitors. These studies employed the major lung carcinogens in tobacco smoke, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo(a)pyrene (BaP). Combining chemopreventive agents that inhibit tumorigenesis by NNK and BaP in rodents may be effective in addicted smokers. PEITC inhibits lung tumor induction by NNK in F-344 rats and A/J mice, while BITC inhibits BaP-induced lung tumorigenesis in A/J mice; combining the two inhibits lung tumorigenesis by combined NNK and BaP in A/J mice. PEITC selectively inhibits metabolic activation of NNK in the rodent lung, while inducing glucuronidation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), one of the major NNK metabolites. Thus, PEITC decreases DNA and hemoglobin adduct formation by NNK while increasing the amounts of NNAL and its glucuronide excreted in the urine. Presently available data indicate that non-toxic doses of PEITC can inhibit the metabolic activation and carcinogenicity of NNK in rat and mouse lung; BITC has similar effects on BaP activation and tumorigenicity in mouse lung. Thus, combinations of chemopreventive agents active against different carcinogens in tobacco smoke may be useful in the chemoprevention of lung cancer.
Targeted Multifunctional Lipid-Based Nanocarriers for Image-Guided Drug Delivery (2007)

Lipid-based nanocarriers have proven successful in the delivery of mainly chemotherapeutic agents, and currently they are being applied clinically in the treatment of various types of cancer. These drug delivery systems achieve increased therapeutic efficacy by altering the pharmacokinetics and biodistribution of encapsulated drugs, resulting in decreased drug toxicity and enhanced accumulation in tumor tissue. This increased accumulation is due to the relatively leaky immature vasculature of a tumor. After the clinical relevance of such drug delivery systems was demonstrated, research in this area focused on optimization, both by cell specific targeting and including controlled and triggered release concepts within the carrier. These more advanced targeted nanocarriers in general have clearly shown their potential in various animal tumor models and await clinical application. The development of targeted nanocarriers in which therapeutic and imaging agents are merged into a single carrier will certainly be of importance in the near future. Indeed, scientists active in the field of imaging (e.g. nuclear and magnetic resonance imaging) have already started to exploit nanocarriers for molecular imaging. Image-guided drug delivery using these multifunctional nanocarriers, containing therapeutic and imaging agents, will ultimately allow for online monitoring of tumor location, tumor targeting levels, intratumoral localization and drug release kinetics prior and during radio- and/or chemotherapeutic treatment. This review describes the current status and challenges in the field of nanocarrier-aided drug delivery and drug targeting and discusses the opportunities of combining imaging probes with these drug carriers and the potential of these multifunctional lipid-based nanocarriers within image-guided drug delivery.
A Stochastic Approach Towards Travel Route Optimization and Recommendation Based on Users Constraints Using Markov Chain (2019)

Accurate analysis of tourist movement is essential for a country to devise sustainable policies for promoting and growing tourism. From the activities of tourists and the spots they visit, the amount of revenue generated for a particular region can be predicted. However, the tourist preferences evolve and vary from one user to another, and thus, a tourist spot favorite for one set of users is not preferred by another set of users. This paper aims to design and implement a novel application to recommend an optimal travel route based on user constraints. The user constraints can be the maximum time, distance, and popularity of a particular place. The real data are collected from the Wi-Fi routers installed at different tourist spots of Jeju Island, South Korea. We apply a Markov chain model to predict the popularity of different places on the short- and long-term bases. The popularity index alongside user constraints is provided to find optimal routes. A responsive web-based prototype is developed to collect user constraints, and, in response, recommends optimal routes using the Google Maps directory services. The results indicate the difference between the short- and long-term popularities to prove the effectiveness of the Markov chains in forecasting long-term behavior. The system is made responsive for all sizes of screens to make it uniformly serviceable on mobile phones. The accuracy of the system is computed based on the historical data and the recommendation system, and it is ascertained to fall between 95% and 100% all the time. Furthermore, the results are compared with popular state-of-the-art methods, and they are found to be significantly better than that in the long-term location prediction.
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism (2021)

Recurring chromosomal translocation t(10;17)(p15;q21) present in a subset of human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed ZMYND11-MBTD1 (ZM); however, its function remains undetermined. Here, we show that ZM confers primary murine hematopoietic stem/progenitor cells indefinite self-renewal capability ex vivo and causes AML in vivo. Genomics profilings reveal that ZM directly binds to and maintains high expression of pro-leukemic genes including Hoxa, Meis1, Myb, Myc and Sox4. Mechanistically, ZM recruits the NuA4/Tip60 histone acetyltransferase complex to cis-regulatory elements, sustaining an active chromatin state enriched in histone acetylation and devoid of repressive histone marks. Systematic mutagenesis of ZM demonstrates essential requirements of Tip60 interaction and an H3K36me3-binding PWWP (Pro-Trp-Trp-Pro) domain for oncogenesis. Inhibitor of histone acetylation-'reading' bromodomain proteins, which act downstream of ZM, is efficacious in treating ZM-induced AML. Collectively, this study demonstrates AML-causing effects of ZM, examines its gene-regulatory roles, and reports an attractive mechanism-guided therapeutic strategy.
Treatment of Hyperphosphatemia With Bixalomer in <scp>J</scp>apanese Patients on Long‐Term Hemodialysis With Gastrointestinal Symptoms (2014)

Bixalomer (Bix) is an amine-functional polymer, non-calcium-containing phosphate (P) binder, and has been clinically available in Japan recently. Bix is expected to cause fewer gastrointestinal (GI) side-effects as compared with sevelamer hydrochloride (SH), because of less expansion of Bix in the GI tract. In this prospective observational study, we evaluated changes in GI symptoms by the Gastrointestinal Symptom Rating Scale (GSRS) score in long-term hemodialysis (HD) outpatients with SH-associated GI symptoms who switched to Bix from SH. A total of 114 patients (age 63.7±10.8 year (mean±SD), female 65.5%, HD vintage 11.2±8.6 years, diabetes mellitus 27.4%) were enrolled. The GSRS score was checked at 0 and 12 weeks after the start of Bix. Bix was started at the initial dose of 750 mg/day, and then was titrated. Serum albumin, P and corrected calcium levels did not significantly change during Bix treatment. However, serum low-density lipoprotein-cholesterol and bicarbonate levels significantly increased during Bix treatment (P<0.001). In GSRS scores, total and domain-specific scores, including constipation, diarrhea, reflux and abdominal pain were significantly reduced at 0, 4, 12 and 24 weeks as compared with those at 0 weeks (P<0.05). This study shows that Bix was well tolerated and managed hyperphosphatemia effectively after switching from SH in Japanese patients on long-term HD. In addition, Bix might be less often associated with GI symptoms as compared with SH.
Single bit full adder design using 8 transistors with novel 3 transistors XNOR gate (2011)

In present work a new XNOR gate using three transistors has been presented, which shows power dissipation of 550.7272W in 0.35m technology with supply voltage of 3.3V. Minimum level for high output of 2.05V and maximum level for low output of 0.084V have been obtained. A single bit full adder using eight transistors has been designed using proposed XNOR cell, which shows power dissipation of 581.542W. Minimum level for high output of 1.97V and maximum level for low output of 0.24V is obtained for sum output signal. For carry signal maximum level for low output of 0.32V and minimum level for high output of 3.2V have been achieved. Simulations have been performed by using SPICE based on TSMC 0.35m CMOS technology. Power consumption of proposed XNOR gate and full adder has been compared with earlier reported circuits and proposed circuit's shows better performance in terms of power consumption and transistor count.
Flexible parameterization strategies in automotive 3D vehicle layout (2017)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
Behavior of rapid thermal annealed ZnO:P films grown by pulsed laser deposition (2007)

The transport properties of as-deposited and rapid thermal annealed phosphorus-doped ZnO films grown by pulsed laser deposition are reported. As-grown ZnO:P samples showed n-type characteristics, presumably due to the formation of antisite PZn defects. Rapid thermal annealing yielded a carrier-type conversion from n- to p-type for the ZnO:P films grown at ∼700 °C; samples grown at substantially lower or higher temperatures tended to remain n-type even after the thermal annealing process. The properties and behavior of the n-to-p conversion are most consistent with the formation of PZn-2VZn as the active acceptor state. Variable magnetic field Hall measurements confirmed the p-type behavior. Phosphorus doping concentrations in the range of 0.5−1.0 at. % were considered, with evidence for P segregation in the higher phosphorus concentrations.
A Decision Support System for Purchasing Management of Large Projects (1988)

This paper describes a model based Decision Support System (DSS) for purchasing materials and components for large projects. The DSS may be used under two scenarios. Under the first scenario, we have a project to execute, and we are looking for a good way to manage the purchasing to minimize the expected costs. The decisions under our control are when and from whom to order each item. Under the other scenario, we are bidding for the project, and wish to assess the costs associated with the purchasing decisions which we should consider before making our bid. In both cases, we take into account expected out of pocket costs as well as lateness and/or expediting penalties. The DSS is designed to help choose the best supplier for each item and schedule the placement of the orders—decisions which are very difficult to make well without such a model based DSS.
The Effectiveness of Sternocleidomastoid Muscle Flap in Preventing Frey's Syndrome Following Parotidectomy (2005)

BACKGROUND AND OBJECTIVES: Frey's syndrome is one of the potential sequelae of parotidectomy. Various medical and surgical treatments have been used in attempt to avoid this embarrassing condition. Recently, interposing barriers between the overlying skin flap and the parotid bed, such as the sternocleidomastoid (SCM) muscle flap, have been used to prevent this condition. The purpose of this study was to evaluate the preventive impact of using this flap on the incidence of Frey's syndrome and to identify the degree of severity in this syndrome between the use of SCM flap and no muscle flap. SUBJECTS AND METHOD: 40 patients who underwent superficial parotidectomy from June 1996 to August 2003 were divided into two groups. One group had SCM flap reconstruction (n=20), and the other did not (n=20). A subjective clinical questionnaire and the objective Minor's starch test were used to evaluate the incidence of this syndrome. A grading system was used to divide Frey's syndrome into mild or severe Frey's syndrome to determine its severity. The test of Pearson-x2 was applied. RESULTS: The association between sweating, flushing, or pain and the use of the flap was not significant. Also, there was no significant association with Minor's starch test and the use of the flap. There was a significant association with mild Frey's syndrome and the presence of the flap (p=0.014). CONCLUSION: It would seem that the sternocleidomastoid muscle flap does not reduce the incidence of Frey's syndrome, but does decrease the degree of severity in Frey's syndrome
Mini-plasminogen: a mechanism for leukocyte modulation of plasminogen activation by urokinase (1981)

Urokinase activation of blood fibrinolysis involves polymorphonuclear leukocytes. To determine if a leukocyte proteinase can modulate plasminogen activation, plasminogen was digested with leukocyte elastase. A major product was a small, approximately 34,000 dalton fragment (mini-plasminogen), without lysine-binding function, but with fibrin-binding activity. After urokinase activation, the resulting mini-plasmin had amidolytic activity for a tripeptide plasmin substrate and fibrinolytic activity. By 125I-fibrin assay, activities of mini-plasmin and plasmin (12 nmole/liter) were 38 and 20 ng fibrin lysed/min, respectively. Lysis times of fibrin clots containing urokinase, and mini-plasminogen or plasminogen (800 nmole/liter), were 282 and 290 sec, respectively. Mini-plasmin and plasmin were inhibited similarly by epsilon-aminocaproic acid and normal plasma, but differed in responses to gel filtration fractions of plasma containing alpha 2-antiplasmin and alpha 2-macroglobulin, the primary and secondary plasmin inhibitors. With purified inhibitors, mini-plasmin required higher concentrations of, or longer preincubation with, alpha 2-antiplasmin, and lower concentrations of, or shorter preincubation with, alpha 2-macroglobulin, to produce inhibition equivalent to that observed with plasmin. Leukocyte elastase digests plasminogen to generate a mini-plasminogen which, when activated by urokinase, has a novel pattern of response to the major plasmin inhibitors in plasma.
β-Adrenergic Receptors in Ischemic and Nonischemic Canine Myocardium: Relation to Ventricular Fibrillation and Effects of Pretreatment with Propranolol and Hexamethonium (1988)

To explore possible roles of the sympathetic nervous system (especially the beta-adrenergic receptor and cAMP system) in the pathogenesis of ventricular fibrillation (VF), the authors examined changes in the number of myocardial beta-adrenergic receptors and the cAMP level in animals showing VF after experimental induction of myocardial ischemia. In animals that developed VF approximately 15 min after coronary ligation, the ischemic myocardium had a significantly larger number of beta-adrenergic receptors (90 +/- 8 fmol/mg protein) and a significantly higher level of cAMP (1.4 +/- 0.17 nmol/g weight) compared with the nonischemic area where the number of beta-receptors was 68 +/- 7 fmol/mg protein and the cAMP level was 0.80 +/- 0.20 nmol/g weight. In animals in which VF was electrically induced 20 min after coronary ligation, no elevation was recorded in the ischemic area in terms of the number of beta-adrenergic receptors (49 +/- 6 fmol/mg protein) and the level of cAMP (0.79 +/- 0.06 nmol/g weight). When animals were pretreated with a beta-blocker or a ganglion blocker, coronary ligation did not result in VF. In the ischemic area of these animals, no significant change was noted in the number of beta-adrenergic receptors (54 +/- 7 fmol/mg protein for animals pretreated with a beta-blocker, 56 +/- 3 fmol/mg protein for animals pretreated with a ganglion blocker). These results suggest that there is a strong correlation between the pathogenesis of VF (observed about 15 min after coronary ligation) and the increase of the number of beta-adrenergic receptors and cAMP levels.
Effects of vitamin A, vitamin A plus zinc, and multiple micronutrients on anemia in preschool children in Chongqing, China. (2012)

This study is to clarify the impact of vitamin A or vitamin A combined with other micronutrients supplementation on anemia and growth in preschoolers. In the present study, a total of 290 preschoolers, aged 36-72 months old were randomly assigned to 3 treatment groups: vitamin A (A group), vitamin A plus zinc (AZ group), and vitamin A combined with additional multiple-micronutrient (AMM group). After 6-month supplementation, the height and height-for-age z-score gains of the AZ group were significantly higher than the other groups; the weight gain of the AMM group was greater than the other groups. Compared with baseline values, the concentrations of hemoglobin, and zinc at the end significantly increased in all 3 groups. The incremental concentrations of hemoglobin in the AMM group were significant higher than in the other two groups. Furthermore, the incremental concentrations of serum retinol in the AMM group, and the increase in serum zinc concentrations in the AZ group were significantly higher, respectively, than in the other groups. These 3 kinds of supplements in the present study are effective in enhancing height gains and are effective in reducing the prevalence of anemia. Supplementation of zinc plus vitamin A is a better way for improving children's height and height-for-age z-score. Vitamin A combined with multiple-micronutrient is more effective in improving the hemoglobin concentrations in preschool children.
A novel patient mobility and rehabilitation robot (2007)

This paper describes a novel Home Lift, Position, and Rehabilitation (HLPR) Chair, designed at National Institute of Standards and Technology (NIST), to provide independent patient mobility for indoor tasks, such as moving to and placing a person on a toilet or bed, and lift assistance for tasks, such as accessing kitchen or other tall shelves. These functionalities are currently out of reach of most wheelchair users. One of the design motivations of the HLPR Chair is to reduce back injury, typically, an important issue in the care of this group. The HLPR Chair is currently being extended to be an autonomous mobility device to assist cognition by route and trajectory planning. This paper describes the design of HLPR Chair, its control architecture, and algorithms for autonomous planning and control using its unique kinematics and concludes with an early version, commercialized HLPR Chair concept.
Introduction of Interfacial Charges to Black Phosphorus for a Family of Planar Devices (2016)

The capabilities to tune the conduction properties of materials by doping or electric fields are essential for the design of electronic devices. However, in two-dimensional materials substitutional doping has been achieved in only a few systems, such as Nb substitutional doping in MoS<sub>2</sub>. Surface charge transfer is still one of the popular ways to control whether the conduction is dominated by holes or electrons. Here, we demonstrate that a capping layer of cross-linked poly(methyl methacrylate) modifies the potential in a black phosphorus (BP) layer so that conduction in the absence of an external electric field is dominated by electrons, rather than holes. Using this technique to form adjoining regions dominated by hole and electron conduction, a family of novel planar devices, such as BP-gated diodes, BP bidirectional rectifier, and BP logic inverters, can be fabricated. The devices are potentially useful for electronic applications, including rectification and switching.
Phantoms for elastography (2002)

Several viscoelastic properties of gelatin materials used in sonography and elastography phantoms are reported. Also reported is a device that was designed and built to make these measurements. Measurement precision with this device is typically within 1%. Finite element analysis was used to study boundary conditions and compressor size (compared to sample size) effects on the estimated elastic modulus. Results of these measurements indicate that gelatin gels are a good choice for elastography phantoms, but that the stiffness of these materials increases with time.
Right into the heart of microRNA-133a: Figure 1. (2008)

MicroRNAs play an essential role in diverse cellular processes, such as proliferation, differentiation, apoptosis, and stress response. Recent studies demonstrate that miRNAs are important for timing developmental decisions and fine-tuning cellular determination in vertebrate heart development. In an elegant set of experiments reported in this issue of Genes & Development, Liu et al. (3242-3254) demonstrate that miR-133a functions as an inhibitor of cardiomyocyte proliferation and a modifier of serum response factor (SRF)-dependent transcriptional signaling in the murine heart. Both targeted deletion and transgenic overexpression of miR-133a can result in the same cardiac phenotype, ventricular septal defect (VSD) and heart failure. The new data add another piece to the puzzle of regulatory networks that are implicated in cardiac disease. It will be interesting to see, if miR-133a is also involved in human heart diseases, especially VSD and dilated cardiomyopathy.