gebhart/patrepeval huggingface dataset:
Combined Orthodontic and Surgical Management of a Skeletal Class III Malocclusion with Mild Asymmetry–a Non Extraction Approach (2014)

Severe orthodontic problem that could neither be treated with growth modification or camouflage often requires combined surgical and orthodontic treatment. As the envelope of discrepancy indicate the limitation in orthodontics a multidisciplinary approach is mandatory while treating a skeletal Class III malocclusion in adults. This case reports describes the management of a 22 year old female patient with skeletal class III malocclusion and mild facial asymmetry treated with a non extraction approach, Decompensation was done before surgery followed by a bilateral sagittal split osteotomy. In reviewing the patient, the goals set at the beginning of treatment were successfully achieved, providing the patient with adequate masticatory function and pleasant facial esthetics.
Descripción e interpretación de las litofacies evaporíticas de Artesa de Segre (Eoceno Superior del NE de la Cuenca del Ebro). (1991)

<b>Aim:</b> Assessment of pharmacokinetic interaction between linagliptin (LNG) and tadalafil (TDL) in healthy males. <b>Methods:</b> First, a novel LC-MS method was developed; second, a Phase IV, open-label, cross-over study was performed. Volunteers took single 20-mg TDL dose on day 1 followed by wash out period of 2 weeks then multiple oral dosing of 5-mg/day LNG for 13 days. On day 13, volunteers were co-administered 20-mg TDL. <b>Results:</b> LNG and TDL single doses did not affect QTc interval. Smoking did not alter pharmacokinetics/pharmacodynamics of LNG and TDL. Co-administration of LNG with TDL resulted in TDL longer time to reach maximum plasma concentration (T<sub>max</sub>), decreased oral clearance (Cl/F) and oral volume of distribution (Vd/F), increased its maximum plasma concentration (C<sub>max</sub>), area under concentration-time curve (AUC), muscle pain and QTc prolongation. <b>Conclusion:</b> LNG and TDL co-administration warrants monitoring and/or TDL dose adjustment.
Selection of <scp>D</scp>‐Amino‐Acid Peptides That Bind to Alzheimer's Disease Amyloid Peptide Aβ<sub>1–42</sub> by Mirror Image Phage Display (2003)

A mirror image phage display approach was used to identify novel and highly specific ligands for Alzheimer's disease amyloid peptide Abeta(1-42). A randomized 12-mer peptide library presented on M13 phages was screened for peptides with binding affinity for the mirror image of Abeta(1-42). After four rounds of selection and amplification the peptides were enriched with a dominating consensus sequence. The mirror image of the most representative peptide (D-pep) was shown to bind Abeta(1-42) with a dissociation constant in the submicromolar range. Furthermore, in brain tissue sections derived from patients that suffered from Alzheimer's disease, amyloid plaques and leptomeningeal vessels containing Abeta amyloid were stained specifically with a fluorescence-labeled derivative of D-pep. Fibrillar deposits derived from other amyloidosis were not labeled by D-pep. Possible applications of this novel and highly specific Abeta ligand in diagnosis and therapy of Alzheimer's disease are discussed.
Identification of Neonatal Hearing Impairment: Hearing Status at 8 to 12 Months Corrected Age Using a Visual Reinforcement Audiometry Protocol (2000)

This may be the largest study to attempt to follow all at-risk infants with behavioral audiometric testing, regardless of screening outcome, in an effort to validate the results of auditory brain stem response, distortion product otoacoustic emission, and transient evoked otoacoustic emission testing in the newborn period. It is one of only a few studies to report hearing status of infants at 1 yr of age, using VRA on a clinical population. Successful testing of more than 95% of the infants who returned for the VRA follow-up documents the feasibility of obtaining monaural behavioral data in this population.
A process-tolerant cache architecture for improved yield in nanoscale technologies (2005)

Process parameter variations are expected to be significantly high in a sub-50-nm technology regime, which can severely affect the yield, unless very conservative design techniques are employed. The parameter variations are random in nature and are expected to be more pronounced in minimum geometry transistors commonly used in memories such as SRAM. Consequently, a large number of cells in a memory are expected to be faulty due to variations in different process parameters. We analyze the impact of process variation on the different failure mechanisms in SRAM cells. We also propose a process-tolerant cache architecture suitable for high-performance memory. This technique dynamically detects and replaces faulty cells by dynamically resizing the cache. It surpasses all the contemporary fault tolerant schemes such as row/column redundancy and error-correcting code (ECC) in handling failures due to process variation. Experimental results on a 64-K direct map L1 cache show that the proposed technique can achieve 94% yield compared to its original 33% yield (standard cache) in a 45-nm predictive technology under /spl sigma//sub Vt-inter/=/spl sigma//sub Vt-intra/=30 mV.
Implementing Automotive Telematics for Fleet Insurance (2013)

Prospects for the wind energy market have proposed changes of focus to managerial issues. The objective of this article is to map the specific market factors from Brazilian wind energy industry, in order to develop reflections and considerations on the subject, towards to the managerial, strategic and commercial development of the sector. Through an exploratory methodology in empirical format, and by a SWOT analysis of Telescopic Observations Strategic Framework, were found results that show funding and grants determined by Brazilian government, as the big question of the wind energy industry marketing, allowing the economic viability of wind energy projects. Further, it appears that the wind energy industry is eager to investments and has great potential for new business, but there are problems within the producing companies which that have to be assessed, such as the competitiveness capability, the high equipment costs, the installation locations limitations and lack of specialized employees with specific skills and capacities.
DNA sequence relationships and origins of acetohydroxy acid synthase genes of <i>Brassica napus</i> (1992)

The allotetraploid Brassica napus has been shown to contain a five-member multigene family (AHAS1 – 5) of the nuclear-encoded chloroplastic enzyme acetohydroxy acid synthase, three members of which are expressed. AHAS1 and AHAS3 are constitutively expressed while AHAS2 expression is ovule- and seed-specific. By sequence and phylogenetic analyses we show that the AHAS1 and AHAS3 genes are 96–98% similar in the coding region and the adjacent 5′ and 3′ noncoding regions and were derived from a common ancestral crucifer gene. In contrast, the AHAS2 gene shares only about 80% sequence similarity with the AHAS1 and AHAS3 genes, limited to the region coding for the mature peptide and in a short region of the presumptive transit peptide. The AHAS2 gene likely arose by gene duplication of a housekeeping AHAS gene and has acquired characteristics different from other plant housekeeping AHAS genes, perhaps owing to different functional constraints. Key words: acetohydroxy acid synthase, Brassica napus, phylogenetic inference, multigene family, DNA sequence.
Consumer Devices Get Smart (2015)

This chapter contains sections titled: A World without Wires, Connections Count, The Rise of Protocols and Platforms, The IoT Meets the Real World, Home Automation Gets Real, A Healthy Outlook, Money Matters, Planes, Trains, and Automobiles, A New Era of Shopping Emerges, Putting Connections to Work
Oral Human Brain Natriuretic Peptide Activates Cyclic Guanosine 3′,5′-Monophosphate and Decreases Mean Arterial Pressure (2005)

This study reports for the first time that novel conjugated oral BNP activates cGMP and significantly reduces MAP, thus implying an efficacious coupling of CONJ-hBNP to the natriuretic receptor-A. These data advance a new concept of orally administered chronic BNP therapy for cardiovascular diseases.
Mid-Infrared Single-Photon Detection Using Superconducting Nanowires Integrated with Nano-Antennae (2010)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text X. Hu, F. Marsili, F. Najafi, and K. K. Berggren, "Mid-Infrared Single-Photon Detection Using Superconducting Nanowires Integrated with Nano-Antennae," in Conference on Lasers and Electro-Optics 2010, OSA Technical Digest (CD) (Optica Publishing Group, 2010), paper QThD5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Resistance to topoisomerase poisons due to loss of DNA mismatch repair (2001)

Sporadic breast carcinomas demonstrate microsatellite instability, reflecting the presence of DNA mismatch repair-deficient cells, in about one fourth of cases at the time of diagnosis. Loss of DNA mismatch repair has been reported to result in resistance not only to cisplatin and alkylating agents but also to the topoisomerase II poison doxorubicin, suggesting an association between DNA mismatch repair and topoisomerase II poison-induced cytotoxicity. Our study investigates the relationship between loss of MSH2 or MLH1 function and sensitivity to the topoisomerase I and II poisons, and to the taxanes, 2 classes of cytotoxic drugs commonly used in breast cancer. Two pairs of cell lines proficient and deficient in mismatch repair due to loss of either MSH2 or MLH1 function were used. Loss of either MSH2 or MLH1 function resulted in resistance to the topoisomerase II poisons doxorubicin, epirubicin and mitoxantrone, whereas only loss of MLH1 function was associated with low-level resistance to the topoisomerase I poisons camptothecin and topotecan. In contrast, there was no resistance to docetaxel and paclitaxel. Our data support the hypothesis that both MSH2 and MLH1 are involved in topoisomerase II poison-mediated cytotoxicity, whereas only MLH1 is involved in topoisomerase I poison-mediated cytotoxicity. Since our study shows that loss of DNA mismatch repair does not result in resistance to the taxanes, these drugs can be recommended for use in breast cancer deficient in mismatch repair.
Methods for increasing the rating of overhead lines (2005)

At the present time, there is great pressure to increase the power flow in existing right of ways using existing infrastructure as far as possible. In this paper, the diverse options for increasing the rating of overhead lines are presented and analyzed. By means of a comparative study, their advantages and drawbacks are highlighted. In addition, the factors that determine the choice of the method are analyzed.
Detection of progressive transmission loss due to haze with Galileo mask DUV transmittance mapping based on non imaging optics (2008)

reporting the use of high sensitivity DUV transmission metrology as a means for detection of progressive transmission loss on mask and pellicle surfaces. We also report a use case for incoming reticle qualification based on DUV transmission uniformity. Traditional inspection systems rely on algorithms to locate discrete defects greater than a threshold size (typically > 100nm), or printing a wafer and then looking for repeating defects using wafer inspection and SEM review. These types of defect inspection do not have the ability to detect transmission degradation at the low levels where it begins to impact yield. There are numerous mechanisms for transmission degradation, including haze in its early, thin film form, electric-field induced field migration, and pellicle degradation. During the early development of haze, it behaves as a su rface film which reduces 193nm transmission and requires compensation by scanner dose. The film forms in a non-uniform fashion, resulting from non-uniformity of exposure on the pattern side due to varying dose passing through the attenuating layers. As this non-uniformity evolves, there is a gradual loss of wafer critical dimension uniformity (CDU) due to a degradation of the exposure dose homogeneity. Electric-field induced migration also appears to manifest as a non-uniform transmission loss, typically presenting with a radial signature. In this paper we present evidence that a DUV transmissi on measurement system, Galileo, is capable of detecting low levels of transmission loss, prior to CDU related yield lo ss or the appearance of prin ting defects. Galileo is an advanced DUV transmission metrology system which utilizes a wide-band, incoherent light source and non-imaging optics to achieve sensitivities to transmission changes of less than 0.1%. Due to its very high SNR, it has a fast MAM time of less than 1 sec per point, measuring a full field mask in as little as 30 minutes. A flexible user interface enables users to easily define measurement recipes, threshold sensitivities, and time-based tracking of transmission degradation. The system measures throug h pellicle under better than class 1 clean air conditions. Keywords: Transmission, DUV, 193nm, Haze, Electric-field induced migration (EFM), Photomask, Non imaging optics, Dose, CDU INTRODUCTION A key feature of a photomask is the tr ansmission property of its many surfaces . Typical advanced 6 masks have 4 surfaces: back side quartz, front side pattern, inside pellicle and outside pellicle. In addition to the surfaces themselves the bulk of the transparent materials- fused silica which is the mate rial out of which the blank quartz is made and fluoropolymer out of which the pellicle is made, have specific optical transmission properties which contribute to the total Tr properties of the mask. Also surface coating materials like Cr, MoSi and anti-reflective
Soft shape memory in main-chain liquid crystalline elastomers (2010)

The field of shape memory polymers (SMPs) has been dominated by polymeric network systems whose fixing mechanism is based on crystallization or vitrification of the constituent chains, rendering such systems stiff in comparison to elastomers, gels, and living tissues. In this report, we describe the synthesis and characterization of liquid crystalline elastomers that exhibit both bulk and surface shape memory effects with compositionally dependent transition temperatures that determine the shape fixing and shape recovery critical temperatures. Main-chain, segmented liquid crystalline elastomers were synthesized using hydrosilylation linking of poly(dimethylsiloxane) oligomers with mesogenic dienes of two compositions and a tetrafunctional crosslinker. Calorimetric and dynamic mechanical analyses revealed two composition-determined thermal transitions for the LCEs, including a glass transition event at low temperatures (33 °C < Tg < 48 °C) and a first-order isotropization transition at higher temperatures (57 °C < Ti < 71 °C), each increasing with an increase in the concentration of the more slender, unsubstituted mesogenic diene, 5H. Despite the existence of a glass transition event, the materials remain soft at low temperature, a finding explained by vitrification of only the mesogen-rich layers within the smectic phase. Shape memory behavior was evaluated quantitatively and revealed excellent shape fixing and shape recovery values, generally in excess of 98%, with the recovery temperature depending on composition in a manner determined by the LCE phase behavior, particularly Tg. The temperature-dependent kinetics of shape memory were analyzed for a selected LCE composition, revealing exponential time dependence with rate constants that depended on temperature in an Arrhenius manner. Finally, the softness of the LCE SMPs was exploited to fix an embossed, micron-scale pattern on the surface and then recover the equilibrium flat state quite completely. We envision application of this surface shape memory phenomenon in the areas of soft lithography, especially microcontact printing and microfluidics.
Mechanical monolithic sensor for low-frequency seismic noise measurement (2007)

This paper describes a new low-frequency seismic sensor for geophysical applications. The instrument is basically a monolithic tunable folded pendulum with an interferometric readout system, that can be configured as seismometer or as accelerometer. The monolithic mechanical design and the introduction of a laser interferometric technique for the readout implementation make it a very sensitive and compact instrument with a very good immunity to environmental noises. The theoretical sensitivity curve is calculated considering the brownian noise, the readout noise and the data acquisition noise. Preliminary tests on the mechanical performances of the monolithic structure and on the optical readout have been performed. Interesting result is the measured resonant frequency of the instrument of ≈ 150<i>mHz</i> obtained with a rough tuning, demonstrating the feasibility of a resonant frequency of the order of 5<i>mHz</i> with a more refined tuning. The transfer function of the folded pendulum in open loop configuration is calculated measuring the resonant frequency and the quality factor for several step responses. Then a PID controller is added to implement the closed loop configuration. The mechanics of the seismic sensor, the optical scheme of the readout system, the theoretical predictions and the preliminary experimental performances as accelerometer are discussed in detail, together with the foreseen further improvements.
Platelet washing to prevent recurrent febrile reactions to leucocyte‐reduced transfusions (2001)

Symptoms of fever and/or rigours after transfusion continue to occur commonly in patients receiving platelets leucocyte-reduced after storage. A cohort of 24 consecutive patients who had experienced severe or repeated febrile nonhaemolytic reactions to post-storage leucocyte-reduced platelet transfusions were treated with saline-washed, post-storage leucocyte-reduced platelets. The frequency of reactions declined from 20% of transfusions (n = 191) to 0.6% (n = 331) after instituting saline-washed, post-storage leucocyte-reduced platelet transfusions. These results support the hypothesis that substances present in the supernatant of stored platelet concentrates mediate febrile nonhaemolytic transfusion reactions, and provide one strategy for preventing their occurrence.
Novel physical-layer impairment-aware routing algorithm for translucent optical networks with 43 Gb/s and 107 Gb/s channels (2009)

We present a novel constraint-based routing (CBR) algorithm, which accurately estimates linear and nonlinear physical-layer impairments of 43 and 107 Gb/s channels with duobinary and DQPSK modulation formats by combining fast analytical models for assessing the linear transmission impairments with a split-step Fourier approach optimized for computational speed to estimate the nonlinear intra-channel effects. Our CBR algorithm allows a significant increase in average and maximum transparent distance and thus a reduction in the number of required regenerators.
Depth based two-step disparity vector derivation for AVS2-3D (2016)

AVS2-3D is the 3D extension of AVS2 (audio video coding standard 2), which is under the development of AVS Working Group. In current design of AVS2-3D, the picture-level global disparity vector (GDV) is adopted as the disparity vector (DV) for all blocks in a picture. However, due to the objects with varying depth within one picture, the accuracy of GDV is not enough. In this paper, a block-level depth information based DV derivation method is proposed for AVS2-3D. In order to get a more accurate DV for current block, two corresponding depth blocks are used in this method. Compared with the original GDV in AVS2-3D, it achieves an average of 3.43% and 2.09% bit-saving for all coded three views and synthesized six views, respectively. Additionally, the proposed design is also compared with the depth oriented neighbouring block based DV derivation (DoNBDV) of 3D-HEVC in AVS2 platform and the experimental results show that the method proposed provides an average of 0.35% and 0.36% coding gain compared with the DoNBDV.
Topical pimecrolimus in the treatment of vitiligo. (2007)

Although the treatment of vitiligo has improved during the last decade, therapy is still not satisfactory for many patients. Recently topical calcineurin inhibitors were introduced in the treatment of atopic dermatitis. Considering the autoimmune hypothesis of vitiligo pathogenesis, the use of these topical calcineurin inhibitors seems reasonable. Most clinical vitiligo trials have been performed with tacrolimus and show beneficial effects. Concerning the value of pimecrolimus in the treatment of vitiligo only few data are available. Therefore we performed an open pilot study in 26 patients to evaluate the efficacy and safety of 1% pimecrolimus in the treatment of vitiliginous lesions in the head and neck region. In 13 of 26 (50%) evaluated target lesions, repigmentation was noted after a 6 month treatment period with a median percentage of repigmentation of 72.9% (interquartile range: 30.5-98.3%). Duration of vitiligo and total affected body surface area tended to be inversely correlated with the success rate of treatment. Side effects were mainly limited to a burning sensation at the application site. Despite the promising results of topical immunomodulators in the treatment of vitiligo, prudence is in order, as long-term follow up studies are still lacking.
Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord (2015)

Adult rat and human spinal cord neural stem/progenitor cells (NSPCs) cultured in growth factor-enriched medium allows for the proliferation of multipotent, self-renewing, and expandable neural stem cells. In serum conditions, these multipotent NSPCs will differentiate, generating neurons, astrocytes, and oligodendrocytes. The harvested tissue is enzymatically dissociated in a papain-EDTA solution and then mechanically dissociated and separated through a discontinuous density gradient to yield a single cell suspension which is plated in neurobasal medium supplemented with epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and heparin. Adult rat spinal cord NSPCs are cultured as free-floating neurospheres and adult human spinal cord NSPCs are grown as adherent cultures. Under these conditions, adult spinal cord NSPCs proliferate, express markers of precursor cells, and can be continuously expanded upon passage. These cells can be studied in vitro in response to various stimuli, and exogenous factors may be used to promote lineage restriction to examine neural stem cell differentiation. Multipotent NSPCs or their progeny can also be transplanted into various animal models to assess regenerative repair.
Development of an estimated glomerular filtration rate formula in cats (2018)

An eGFR formula for cats that adjusted serum creatinine concentration for a marker of muscle mass was developed. The formula did not provide a reliable estimate of GFR, and therefore, its routine use cannot be recommended.
Single-Channel Speech Separation with Auxiliary Speaker Embeddings (2019)

We present a novel source separation model to decompose asingle-channel speech signal into two speech segments belonging to two different speakers. The proposed model is a neural network based on residual blocks, and uses learnt speaker embeddings created from additional clean context recordings of the two speakers as input to assist in attributing the different time-frequency bins to the two speakers. In experiments, we show that the proposed model yields good performance in the source separation task, and outperforms the state-of-the-art baselines. Specifically, separating speech from the challenging VoxCeleb dataset, the proposed model yields 4.79dB signal-to-distortion ratio, 8.44dB signal-to-artifacts ratio and 7.11dB signal-to-interference ratio.