gebhart/patrepeval huggingface dataset:
Induction of Biologically Active Antibodies in Mice, Rabbits, and Monkeys by Plasmodium falciparum EBA-175 Region II DNA vaccine (2001)

By proving the hypothesis that anti-RII antibodies can block merozoite invasion of erythrocytes, these studies pave the way for the clinical evaluation of EBA-175 as a receptor-blockade vaccine.
Electronic musical instrument (1979)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Masanobu Chibana, Tsuyoshi Futamase, Hideo Yamada; Electronic musical instrument. J. Acoust. Soc. Am. 1 October 1979; 66 (4): 1236. https://doi.org/10.1121/1.383355 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Flare compensation for EUVL (2009)

At Selete, correction for flare based on a flare point-spread function (PSFF) is investigated. We divide a layout into a grid and calculate pattern density for each grid square, obtaining a density array as an approximation to the layout aerial image. Then, the density array is convolved with the PSFF to create an array of flare values. Using this flare-value array, we resize the layout. In the above correction flow, size of a grid square of density array and a selection of an approximate function of the PSFF have a great influence on the accuracy of flare value computation. In this study, correction for flare was applied to the fabrication of several test masks using the real PSFF obtained from a full-field step-and-scan exposure tool called EUV1. We report on the optimization of size of grid square, on a suitable approximation model of PSFF, and on feedbacks from exposure experiments.
Microcomputer-based programmable optical correlator for automatic pattern recognition and identification (1986)

A microcomputer-based programmable optical correlator (MPOC) is proposed for automatic pattern recognition and identification. A programmable magneto-optic spatial light modulator and a liquid-crystal light value are used to perform a real-time joint-transform correlation operation. Since the proposed MPOC consists of a microcomputer and an optical processing system, it has the advantage of real-time programmable processing capability for large space-bandwidth-product information. The basic theory and a feasibility study of the technique are given.
Two-to-Five Channel Sound Processing * (2002)

<p>While stereo music reproduction was a dramatic advance over mono, recently a transition to multichannel audio has created a more involving experience for listeners. An algorithm to convert stereo to five-channel sound reproduction is presented. An effective sound distribution to the surround channels is achieved by using a cross-correlation technique, and a robust stereo image is obtained using principal component analysis. Informal listening tests comparing this scheme with other methods revealed that the proposed algorithm is preferred for both on and off the reference listening position (sweet spot).</p>
A user friendly system for ultrasound carotid intima-media thickness image interpretation (2011)

Assessment of Carotid Intima-Media Thickness (CIMT) by B-mode ultrasound is a technically mature and reproducible technology. Given the high morbidity, mortality and the large societal burden associated with CV diseases, as a safe yet inexpensive tool, CIMT is increasingly utilized for cardiovascular (CV) risk stratification. However, CIMT requires a precise measure of the thickness of the intima and media layers of the carotid artery that can be tedious, time consuming, and demand specialized expertise and experience. To this end, we have developed a highly user-friendly system for semiautomatic CIMT image interpretation. Our contribution is the application of active contour models (snake models) with hard constraints, leading to an accurate, adaptive and user-friendly border detection algorithm. A comparison study with the CIMT measurement software in Siemens Syngo® Arterial Health Package shows that our system gives a small bias in mean (0.049 ±0.051mm) and maximum (0.010 ± 0.083 mm) CIMT measures and offers a higher reproducibility (average correlation coefficients were 0.948 and 0.844 in mean and maximum CIMT respectively (P <0.001)). This superior performance is attributed to our novel interface design for hard constraints in the snake models.
Direct, Simplified, and Sensitive Assay of Angiotensin II in Plasma Extracts Performed with a High-Affinity Monoclonal Antibody (1992)

A very simple, fast, and sensitive RIA of angiotensin (Ang) II has been developed, based on a monoclonal antibody with high affinity and specificity, making possible the direct measurement of circulating Ang II in human plasma after solid-phase extraction. The purified monoclonal antibody 4D8 has an association constant of 1.3 x 10(11) L/mol with Ang II and a cross-reactivity of < 1% for Ang I. The assay can detect as little as 0.8 fmol of Ang II in 2 mL of plasma and is not influenced by the presence of Ang I. Analytical recoveries between 112% and 116% were obtained for Ang II added to human plasma at physiological concentrations. Comparison of the RIA with a reversed-phase, high-performance liquid chromatographic method followed by RIA to measure Ang II in human plasma samples from normal and hypertensive subjects--and from normotensive subjects before and after an acute inhibition of angiotensin-converting enzyme with captopril (50 mg)--showed a high degree of correlation (r2 = 0.93) between the two methods.
Highly Tensioned Suspended Pipelines (2000)

In 1996, ARCO Technology and Operations Support (ARCO TOS) began considering Highly Tensioned Suspended Pipelines (HTSPs) as a promising concept for above ground, cross-country pipelines in Arctic regions. HTSPs resemble high voltage, cross-country power lines. Similar construction methods and support towers are used. The primary differences are that the pipelines are larger in diameter and are supported against out-of-plane wind loads. Three years of development work are summarized in this paper. This work includes analytical modeling, pipeline code compliance, conceptual design of components, and construction studies. Fatigue resistance under North Slope Alaska wind conditions is estimated. HTSPs are judged to be technically feasible and a cost effective alternative to traditional elevated pipelines.
A model-based calibration method for diffuse optical tomography (2000)

We report a model-based calibration method that allows absolute calibration of measurements of diffuse photon fluence without making reference to a previous instrument calibration. It also makes possible to image reconstruction from a single set of measurement.
Multielements doped silica glass based specialty optical fibers for high power optical amplifiers (2020)

We have developed multielments (Al, Ge, P, Ce, B , F) doped silica glass based Er/Yb specialty optical fibers for high power optical amplifiers showing efficiency above 41.0% with stable output power and radiation hardness behavior.
TMAP @ IFE - A Framework for Guiding and Monitoring Thermal Ablations (2010)

In our system, we used the temperature dependence of the proton resonance frequency (PRF) for spatial and temporal temperature measurements during the intervention. The PRF shift method [3] is currently the most widely used MR thermometry method at mid and high field. The TMAP tool has been developed to be compatible with gradient echo, single shot EPI and segmented EPI PRF sequences. To provide an intuitive and clear user interface, the presented TMAP application features visualization of up to three multiplanar slices during the thermal ablation. Anatomical (magnitude) and thermal (phase-based) images can be visualized either separately or fused, with flexibility to change the visualization mode interactively during the thermal ablation procedure. In line with the IFE, the application provides visualization of imaging slices in individual 2D views, as well as in a 3D graphic which gives information about the orientation of the slices in 3D space. Systematic on-line quality control features were developed to ensure the reliability of the displayed temperature maps. A three-pronged approach to maintain measurement quality was used. First, an assumption was made that the standard deviation of the temperature measurement in an unheated region can be used to track the quality of the measurements. As such, TMAP was designed to monitor this value in a user-defined region of interest (ROI) and to give feedback to the physician when it exceeds a predefined value. Second, real-time motion monitoring was implemented by evaluating normalized mutual information (NMI) in sequential images throughout the image acquisition. In addition, users can view the difference images between the current and baseline magnitude image to individually evaluate effects. Further, if desired, users are allowed to select a threshold value with respect to the NMI index to remove outliers from the thermal dose calculation. In order to quantitatively assess the progress of ongoing thermal damage, the system supports both the display of thermal damage based on CEM 43 (cumulative equivalent minutes at 43°C) or the Arrhenius model [4]. In addition, the temperature/ thermal dose over time can be monitored for selected points. The physician can, for example, place one seed point inside the ablation zone, one in the safety margin, and one in the non-heated region.
Immune modulation using transdermal photodynamic therapy (1995)

The photosensitizer benzoporphyrin derivative monoacid ring A (Verteporfin<SUP>R</SUP> or BPD) has maximum absorption characteristics (690 nm) and biodistribution characteristics which permit activation of the drug in capillaries of the skin without causing skin photosensitivity (transdermal PDT). This permits targeting of cells in the circulation for selective ablation. Since BPD has been shown to accumulate preferentially in activated lymphocytes and monocytes, studies have been undertaken to determine the effect of transdermal PDT on murine models for rheumatoid arthritis (the MRL/lpr adjuvant enhanced model) and multiple sclerosis (the experimental allergic encephalomyelitis (EAE) model in PL mice). Localized transdermal PDT with BPD was found to be completely successful in preventing the development of adjuvant enhanced arthritis in the MRL/lpr mouse as well as improving the underlying arthritic condition of these animals. In the EAE model, in which an adoptive transfer system was used, it was found that transdermal PDT of recipients was effective in preventing EAE if treatments were implemented up to 24 hours after cell transfer but was not effective if given later, indicating the requirement for circulating T cells for effective treatment.
High Linearity Voltage Response Parallel-Array Cell (2014)

We studied in detail a cell consisting of two parallel SQUID arrays or two parallel superconducting interference filters (SQIFs) connected differentially with the goal of achieving highly linear voltage response to magnetic signal. In these different cell designs, we accounted for realistic values of coupling inductances in contrast to limiting case of vanishing inductances considered earlier. We found that a cell based on regular parallel SQUID arrays produces higher linearity as compared to the cell based on SQIFs. This high-linearity cell can be used for realizing Superconducting Quantum Arrays (SQA) capable of providing a broadband, highly-linear magnetic field-to-voltage transfer function and high dynamic range.
Elongase And Uses Thereof (Patent US 8119861 B2) (2012)

The invention relates to nucleic acid derived from Perkinsus marinus which encodes a 9-elongase, a Δ8-desaturase and a Δ5-desaturase enzyme. All of the coding sequences can be transcribed as a single transcript.
Rendering articulated figures from examples (2003)

This paper presents new methods to robustly track and interpolate images of complex articulated figures. Traditional interpolation approaches fail on these cases since appearance is not necessarily a smooth function nor a linear manifold. We show how to model such appearance mappings with sets of examples which are each smooth functions. These well-behaved groups can cover overlapping regions of parameter space, and are empirically validated. A set growing procedure is used to find example clusters which are well-approximated within their convex hull; interpolation then proceeds only within a single such set. With this method physically valid images are produced even in regions of parameter space where the overall mapping is singular and nearby examples have different appearances. Our analysis stage tracks the occluding boundaries of articulated figures, even when there is no foreground contrast on an individual limb. Results generating both simulated and real arm images are demonstrated.
Extracting fundamental transverse mode operation in broad area quantum cascade lasers (2016)

Power scaling in broad area quantum cascade lasers results in the operation of high order transverse modes with a far-field profile consisting of two lobes propagating at large angles relative to the optical axis. We report a method of suppressing the high order transverse modes that can extract the fundamental mode and provide emission along the optical axis. By generating a lateral constriction in the waveguide in the form of short trenches defined by the focused ion beam milling technique, we report broad area devices in which most of the power is contained in a near diffraction-limited beam that provides high brightness.
Eleutherococcus senticosus (Araliaceae) Leaf Morpho-Anatomy, Essential Oil Composition, and Its Biological Activity Against Aedes aegypti (Diptera: Culicidae) (2017)

The roots of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim., a well-known medicinal plant from Eastern Asia, are used worldwide for their known beneficial medicinal properties. Recently, the leaves have been used as an alternative to the roots. The present study was aimed at exploring the leaf essential oil as a potential source of compounds for mosquito management. Gas chromatography/mass spectrometry analysis of the leaf essential oil revealed 87 compounds, constituting 95.2% of the oil. α-Bisabolol (26.46%), β-caryophyllene (7.45%), germacrene D (6.87%), β-bisabolene (4.95%), and α-humulene (3.50%) were five of the major constituents. The essential oil was subjected to biting deterrence and repellent activity against mosquito Aedes aegypti. The biting deterrence of the oil produced a proportion not biting (PNB) value of 0.62 at 10 µg/cm2 as compared with 0.86 of control DEET (N,N-diethyl-3-methylbenzamide) at a standard dose of 25 nmol/cm2. Among individually selected compounds present in the oil (α-bisabolol, β-caryophyllene, α-humulene, and caryophyllene oxide), only α-bisabolol produced a PNB value of 0.80, equivalent to DEET at 25 nmol/cm2, whereas the others were not repellent. The artificial mixture (AMES-1) of these four selected compounds produced a relatively high PNB value of 0.80. The repellent activity measured by minimum effective dosage (MED) for α-bisabolol and α-humulene produced MED values of 0.094 and 0.104 mg/cm2, respectively, as compared with 0.023 mg/cm2 of DEET. The leaf essential oil, the artificial mixture (AMES-1), and other binary and tertiary combinations of major compounds showed no repellent activity. In addition, morpho-anatomical features of the leaf are provided for correct identification of the species.
Code compression for embedded VLIW processors using variable-to-fixed coding (2006)

In embedded system design, memory is one of the most restricted resources, posing serious constraints on program size. Code compression has been used as a solution to reduce the code size for embedded systems. Lossless data compression techniques are used to compress instructions, which are then decompressed on-the-fly during execution. Previous work used fixed-to-variable coding algorithms that translate fixed-length bit sequences into variable-length bit sequences. In this paper, we present a class of code compression techniques called variable-to-fixed code compression (V2FCC), which uses variable-to-fixed coding schemes based on either Tunstall coding or arithmetic coding. Though the techniques are suitable for both reduced instruction set computer (RISC) and very long instruction word (VLIW) architectures, they favor VLIW architectures which require a high-bandwidth instruction prefetch mechanism to supply multiple operations per cycle, and fast decompression is critical to overcome the communication bottleneck between memory and CPU. Experimental results for a VLIW embedded processor TMS320C6x show that the compression ratios using memoryless V2FCC and Markov V2FCC are around 82.5% and 70%, respectively. Decompression unit designs for memoryless V2FCC and Markov V2FCC are implemented in TSMC 0.25-/spl mu/m technology.
Metathesis polymerization of N-phenylnorbornenedicarboximide (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetathesis polymerization of N-phenylnorbornenedicarboximideJawed AsrarCite this: Macromolecules 1992, 25, 20, 5150–5156Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ma00046a006https://doi.org/10.1021/ma00046a006research-articleACS PublicationsRequest reuse permissionsArticle Views371Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultrasensitive Detection and Quantification of Toxins for Optimized Diagnosis of Clostridium difficile Infection (2015)

Recently developed ultrasensitive and quantitative methods for detection of Clostridium difficile toxins provide new tools for diagnosis and, potentially, for management of C. difficile infection (CDI). Compared to methods that detect toxigenic organism, ultrasensitive toxin detection may allow diagnosis of CDI with increased clinical specificity, without sacrificing clinical sensitivity; measurement of toxin levels may also provide information relevant to disease prognosis. This minireview provides an overview of these new toxin detection technologies and considers what these new tools might add to the field.
Picture-graphics color image classification (2003)

High-level (semantic) image classification can be achieved by analysis of low-level image attributes geared for the particular classes. In this paper, we have proposed a novel application of the known image processing and classification techniques to achieve such a high-level classification of color images. Our image classification algorithm uses three low-level image features: texture, color, and edge characteristics to classify a color image into two classes: business graphics or natural picture. We have achieved an accuracy of 96.6% on our database of 209 images using a combination of tree and neural network classifiers.
Metal‐Free Synthesis of Pharmaceutically Important Biaryls by Photosplicing (2018)

Abstract Many pharmaceuticals feature biaryl motifs that are crucial for their binding to the target. Yet, benchmark methods for selective cross‐couplings rely on highly toxic heavy metal catalysts, which are unfavorable in the synthesis of pharmaceuticals. Metal‐free coupling reactions, on the other hand, may require harsh conditions and lack selectivity. We report a novel, metal‐free cross‐coupling reaction that involves the tethering of two phenyl groups by a temporary, traceless sulfonamide linker that directs a photochemical aryl fusion into a single coupling product. The perfect regio‐ and chemoselectivity of the reaction could be rationalized by a cyclic intermediate, which fragments into the biaryl and volatile side products. Using a flow reactor, we synthesized numerous substituted biaryl building blocks for important therapeutics in high yields, such as antibiotics, antitumor, neuroprotective and cholesterol‐lowering agents as well as antiarthritic non‐steroidal antiinflammatory drugs (NSAIDs). The new method was successfully employed in a total synthesis of cannabinol, an important analgesic and antiemetic therapeutic. We also report a metal‐free synthesis of key building blocks used for the preparation of sartans, antihypertensive agents that rank among the top blockbuster drugs worldwide. This safe and convenient protocol is a valuable alternative for the widely used metal‐dependent aryl cross‐coupling methods.
IP Fast ReRoute: Lightweight Not-Via without Additional Addresses (2009)

In order for IP to become a full-fledged carrier- grade transport technology, a native IP failure-recovery scheme is necessary that can correct failures in the order of milliseconds. IP fast reroute (IPFRR) intends to fill this gap, providing fast, local and proactive handling of failures right in the IP layer. Building on experiences and extensive measurement results collected with a prototype implementation of the prevailing IPFRR technique, Not-via, in this paper we identify high address management burden and computational complexity as the major causes of why commercial IPFRR deployment still lags behind, and we present a lightweight not-via scheme, which, according to our measurements, improves these issues.
Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914) (2010)

Alpha-7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment. We report a series of novel, potent small molecule agonists (4-18) of the alpha7 nAChR deriving from our continuing efforts in the areas of Alzheimer's disease and schizophrenia. One of the compounds of the series containing a urea moiety (16) was further shown to be a selective agonist of the alpha7 nAChR with excellent in vitro and in vivo profiles, brain penetration, and oral bioavailability and demonstrated in vivo efficacy in multiple behavioral cognition models. Structural modifications leading to the improved selectivity profile and the biological evaluation of this series of compounds are discussed.