gebhart/patrepeval huggingface dataset:
IL-4-dependent regulation of TGF-alpha and TGF-beta1 expression in human eosinophils. (1998)

TGFs play important roles in wound healing and carcinogenesis. We have previously demonstrated that eosinophils infiltrating into different pathologic processes elaborate TGF-alpha and TGF-beta1. Eosinophils infiltrating hamster cutaneous wounds were found to express TGFs sequentially. In this study, we examined the biologic mediators that may regulate the expression of TGF-alpha and -beta1 by eosinophils. Eosinophils were isolated from the peripheral blood of healthy donors and cultured in the absence or presence of IL-3, IL-4, and IL-5. Cells were analyzed by in situ hybridization and immunohistochemistry. Supernatants from these cultures were assayed for secreted TGF-alpha and TGF-beta1 using TGF-specific ELISAs. IL-3, IL-4, and IL-5 independently up-regulated TGF-beta1 mRNA and product expression by eosinophils in all donors. Interestingly, TGF-alpha production by eosinophils was up-regulated by IL-3 and IL-5 but was down-regulated by IL-4. Consistent with the ability of IL-4 to regulate eosinophil responses, IL-4 signaling molecules are present in human eosinophils. The observation that IL-4 can differentially regulate the expression of TGF-alpha and TGF-beta1 suggests that IL-4 may serve as a physiologic molecular switch of TGF expression by the infiltrating eosinophils in wound healing and carcinogenesis.
Learning via Gaussian Herding (2010)

We introduce a new family of online learning algorithms based upon constraining the velocity flow over a distribution of weight vectors. In particular, we show how to effectively herd a Gaussian weight vector distribution by trading off velocity constraints with a loss function. By uniformly bounding this loss function, we demonstrate how to solve the resulting optimization analytically. We compare the resulting algorithms on a variety of real world datasets, and demonstrate how these algorithms achieve state-of-the-art robust performance, especially with high label noise in the training data. 1
Rapid membrane permeabilization and inhibition of vital functions of gram-negative bacteria by bactenecins (1990)

Bactenecins are a class of arginine-rich antibacterial peptides of bovine neutrophil granules. Two bactenecins with approximate molecular weights of 5,000 and 7,000 designated Bac5 and Bac7, respectively, exert in vitro a potent bactericidal activity toward several gram-negative bacteria (R. Gennaro, B. Skerlavaj, and D. Romeo, Infect. Immun. 57:3142-3146, 1989). We have now found that this activity shows an inverse relationship to the ionic strength of the medium and is inhibited by divalent cations and greatly potentiated by lactoferrin. Under conditions supporting marked bactericidal activity, the two peptides cause a rapid increase in the permeability of both the outer and inner membranes of Escherichia coli, as shown by unmasking of periplasmic beta-lactamase and of cytoplasmic beta-galactosidase. In addition, the two bactenecins inhibit the respiration of E. coli and Klebsiella pneumoniae but not of Bac5- and Bac7-resistant Staphylococcus aureus. Furthermore, they induce a drop in ATP content in E. coli, K. pneumoniae, and Salmonella typhimurium and a marked decrease in the rates of transport and incorporation of [3H]leucine and [3H]uridine into E. coli protein and RNA, respectively. In general, all these effects become evident within 1 to 2 min and reach their maximal expression within about 5 min. Overall, these data strongly suggest that the decrease in bacterial viability is causally related to the increase in membrane permeability and the subsequent fall in respiration-linked proton motive force, with the attendant loss of cellular metabolites and macromolecular biosynthesis ability.
Evaluation of a high avidity anti-dsDNA IgG enzyme-linked immunosorbent assay for the diagnosis of systemic lupus erythematosus. (2011)

The high avidity (HA) anti-dsDNA IgG ELISA is considered highly specific for the diagnosis of systemic lupus erythematosus (SLE). The main objective of this study was to determine the performance of this test with existing assays for detecting anti-dsDNA IgG antibodies as well as assess its analytical characteristics. For method comparison studies, we investigated the correlation between the HA ELISA with 8 other assays for the detection of dsDNA IgG antibodies namely; six anti-dsDNA IgG ELISA, the Crithidia luciliae immunofluorescence test (CLIFT) and an in-house developed Farr radioimmunoassay (RIA). Overall, 125 patient (100 ANA-positive, 25 CLIFT-tested) and 100 healthy control samples were tested. The assay was also evaluated for imprecision, lot-to-lot consistency and the effect of interfering substances using commercial quality control materials based on the manufacturer's claims unless otherwise stated. Of the 100 ANA positive samples, 18 were positive in the HA ELISA with significant levels of antibodies in the six ELISAs and CLIFT. The HA ELISA had a specificity of 100% with an overall agreement of 84% with the RIA. Intra - and inter-assay imprecision ranged from 13.9-16.5% and the reproducibility between lots based on qualitative interpretation was 100%. Hemoglobin, bilirubin and lipemia showed variable interference with assay performance based on the manufacturer's claims and our in-house protocol. Our data suggest that the HA ELISA although less sensitive than the other dsDNA IgG assays evaluated, is specific and predicts high levels of anti-dsDNA IgG antibodies.
Preventing Fairness Gerrymandering: Auditing and Learning for Subgroup Fairness (2017)

The most prevalent notions of fairness in machine learning are statistical definitions: they fix a small collection of pre-defined groups, and then ask for parity of some statistic of the classifier across these groups. Constraints of this form are susceptible to intentional or inadvertent "fairness gerrymandering", in which a classifier appears to be fair on each individual group, but badly violates the fairness constraint on one or more structured subgroups defined over the protected attributes. We propose instead to demand statistical notions of fairness across exponentially (or infinitely) many subgroups, defined by a structured class of functions over the protected attributes. This interpolates between statistical definitions of fairness and recently proposed individual notions of fairness, but raises several computational challenges. It is no longer clear how to audit a fixed classifier to see if it satisfies such a strong definition of fairness. We prove that the computational problem of auditing subgroup fairness for both equality of false positive rates and statistical parity is equivalent to the problem of weak agnostic learning, which means it is computationally hard in the worst case, even for simple structured subclasses. We then derive two algorithms that provably converge to the best fair classifier, given access to oracles which can solve the agnostic learning problem. The algorithms are based on a formulation of subgroup fairness as a two-player zero-sum game between a Learner and an Auditor. Our first algorithm provably converges in a polynomial number of steps. Our second algorithm enjoys only provably asymptotic convergence, but has the merit of simplicity and faster per-step computation. We implement the simpler algorithm using linear regression as a heuristic oracle, and show that we can effectively both audit and learn fair classifiers on real datasets.
Deflagration-to-detonation transition in small-diameter columns of PETN (1981)

The transition from deflagration to detonation in pure pentaerythritol tetranitrate (PETN) confined in small-diameter (2-mm) steel columns of three lengths (6.4, 9.6, and 12.8 mm) was examined. These relatively low density pressings of PETN were deflagrated by donor charges of high-density PETN that had been ignited by a hot wire. A dent produced in an aluminum witness block was the criterion for determining detonation. The transition from burning to detonation occurred in pressings of all three lengths. Detonation velocities sufficient to initiate high-density PETN booster pellets were reached in the 9.6- and 12.8-mm pressings.
Mechanical Drawing of Gas Sensors on Paper (2012)

Schreib′s auf: Das mechanische Abreiben komprimierter einwandiger Kohlenstoffnanoröhren (SWCNTs) auf Papier führt zu Sensoren, die Sub-ppm-Konzentrationen von NH3-Gas detektieren können. Diese Herstellungsmethode ist einfach und preisgünstig. Sie ist vollständig lösungsmittelfrei und umgeht damit die Schwierigkeiten, die sich aus der inhärenten Instabilität vieler SWCNT-Dispersionen ergeben. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats. (1987)

Experiments were designed to study endothelium-dependent responses in salt-sensitive (DS) and salt-resistant Dahl rats (DR). The rats were fed a low sodium (0.1% NaCl) or high sodium (8% NaCl) diet for 8 weeks. Blood pressure in DS fed a high sodium diet was higher than that in the remaining animals. Aortic rings with and without endothelium were suspended for isometric tension recording. Acetylcholine, adenosine 5'-diphosphate, and thrombin induced endothelium-dependent relaxations that were significantly depressed in the aorta of DS fed a high sodium diet. The relaxations in response to sodium nitroprusside were only slightly, but significantly, depressed in DS fed a high sodium diet. Removal of the endothelium greatly enhanced the response to serotonin and norepinephrine. In rings with, but not without, endothelium taken from rats fed a high sodium diet, the tension developed in response to serotonin and norepinephrine was significantly greater than that in animals fed a low sodium diet. These experiments indicate that endothelium-dependent relaxations to acetylcholine, adenosine 5'-diphosphate, and thrombin are depressed in hypertensive Dahl rats; this effect probably reflects a decreased release of endothelium-derived relaxing factor(s), although structural changes might contribute; and the responsiveness to vasoconstrictor agents is increased in DS and DR fed a high sodium diet. These findings may indicate differential effects of blood pressure and dietary salt on endothelial function.
Analysis of metallic nanoparticle-DNA assembly formation in bulk solution via localized surface plasmon resonance shift (2012)

Metallic nanoparticles such as gold and silver are known to exhibit localized surface plasmon resonance (LSPR). Being able to form well defined nanoassemblies of metallic nanoparticles in solution phase can produce LSPR coupling and shift, which represents a unique plasmon signature and have been used for the detection of nanoassembly formation. While most of the existing works focus on nanoassembly formation on a substrate surface, here, we investigated the formation of DNA-modified gold nanoparticle (nAu-DNA) nanoassemblies in bulk solution. Subsequently the nanoassemblies were allowed to bind on a glass substrate in order to study correlations among the LSPR wavelength shift, the plasmon color change, and the nanoassembly structure. We observed that the hybridization percentage of the complementary 50 nm nAu increased with rising nAu concentration, longer hybridization time, and longer complementary duplex DNA length. In addition, due to lower scattering yield and smaller surface area from 10 nm nAu, the 50 nm/10 nm hetero-size system displayed limited observable LSPR shift compared to 50 nm/20 nm hetero-size system, which in turn was inferior to the 50 nm/50 nm homo-size system. For the hetero-size systems, reducing the surface density of ssDNA on the 20 nm and 10 nm nAu also significantly reduced the hybridization percentages. Overall, this study allows us to understand how different experimental parameters can impact the assembly of nAu-DNA probes, particularly the limitation in using smaller size nAu (10 nm) for LSPR study.
Treatment of Atopic Dermatitis and Psoriasis Vulgaris With Bupropion-SR: A Pilot Study (2002)

The generally good tolerability and relative safety of bupropion-SR makes a trial of this agent worthwhile in patients with atopic dermatitis or psoriasis who have failed treatment with more conventional medications. Normalization by bupropion of potentially causative neuroendocrine, immunologic, or catecholaminergic abnormalities in both of these dermatologic disorders is a possible mechanism of action for the observed salutary effects of this drug on our subjects' skin disease.
Application of multipath shape factors in Nakagami-m fading channel (2009)

This paper introduces a new application of multipath shape factors that greatly simplifies the description of Nakagami-m fading channel. The three shape factors are angular spread, angular constriction and azimuthal direction of maximum fading. They are introduced to describe the first-order and second-order statistics of received signal fluctuations in a multipath fading channel. Analytical expressions for level-crossing rate and average fade duration of the most important second-order statistics are both introduced using the shape factor theory. Furthermore, these three shape factors are applied to first-order and second-order Nakagami-m fading channel, then comparison of reduced fading channel with three shape factor and Nakagami-m fading channel is given.
File System Support for Collaboration in theWide Area (2006)

We describe the design, implementation, and performance of MFS, a new file system designed to support efficient widearea collaboration. MFS is structured around the twin abstractions of lightweight sessions and snapshots, along with a highly configurable capability-based security architecture. Sessions simplify and clarify collaborative semantics. Snapshots allow atomic access to arbitrary collections of files, and allow sharing to be defined in a simple and expressive fashion. MFS’s security architecture is a layered system that allows diverse usage scenarios. Pure capability-based access allows clients to access data without needing expensive public key or authentication servers, or complicated administration. However, MFS’s capabilities can also be watermarked, allowing a range of services to be added on a per-mount basis, up to and including traditional user authentication based on passwords or public keys. Basing the system around the use of immutable snapshots enables the underlying system to use several performance optimizations aggressively. Performance results from our MFS prototype show that, far from adding overhead, the use of snapshots allows the system to perform comparably to NFS in the local-area case and significantly outperform existing systems in wide-area environments.
AhpF Can Be Dissected into Two Functional Units:  Tandem Repeats of Two Thioredoxin-like Folds in the N-Terminus Mediate Electron Transfer from the Thioredoxin Reductase-like C-Terminus to AhpC (2000)

AhpF, the flavin-containing component of the Salmonella typhimurium alkyl hydroperoxide reductase system, catalyzes the NADH-dependent reduction of an active-site disulfide bond in the other component, AhpC, which in turn reduces hydroperoxide substrates. The amino acid sequence of the C-terminus of AhpF is 35% identical to that of thioredoxin reductase (TrR) from Escherichia coli. AhpF contains an additional 200-residue N-terminal domain possessing a second redox-active disulfide center also required for AhpC reduction. Our studies indicate that this N-terminus contains a tandem repeat of two thioredoxin (Tr)-like folds, the second of which contains the disulfide redox center. Structural and catalytic properties of independently expressed fragments of AhpF corresponding to the TrR-like C-terminus (F[208-521]) and the 2Tr-like N-terminal domain (F[1-202]) have been addressed. Enzymatic assays, reductive titrations, and circular dichroism studies of the fragments indicate that each folds properly and retains many functional properties. Electron transfer between F[208-521] and F[1-202] is, however, relatively slow (4 x 10(4) M(-)(1) s(-)(1) at 25 degrees C) and nonsaturable up to 100 microM F[1-202]. TrR is nearly as efficient at F[1-202] reduction as is F[208-521], although neither the latter fragment, nor intact AhpF, can reduce Tr. An engineered mutant AhpC substrate with a fluorophore attached via a disulfide bond has been used to demonstrate that only F[1-202], and not F[208-521], is capable of electron transfer to AhpC, thereby establishing the direct role this N-terminal domain plays in mediating electron transfer between the TrR-like part of AhpF and AhpC.
Lactic acid production by new Lactobacillus plantarum LMISM6 grown in molasses: optimization of medium composition (2011)

A Plackett-Burman experimental design was used to evaluate seven medium components added to molasses (corn steep liquor, sodium acetate, magnesium sulfate, manganese sulfate, ammonium citrate, potassium phosphate and Tween 80). Corn steep liquor (CSL), K 2 HPO 4 and Tween 80 increased lactic acid production. The concentrations of these three components as well as the molasses were further optimized using the response surface method. A maximal lactic acid production of 94.8 g L -1 was obtained when the concentrations of molasses, CSL, K 2 HPO 4 and Tween 80 were 193.50 g L -1 , 37.50 mL L -1 , 2.65 g L -1 and 0.83 mL L -1 , respectively. However, in both shaker and bioreactor, approximately one fourth of the sugar added initially was not utilized after 48 hours of fermentation. Future studies that consider high conversion of sugar into final product as well as high volumetric productivity are necessary to improve the fermentation process and to reduce the downstream costs.
Efficient superscalar performance through boosting (1992)

The foremost goal of superscalar processor design is to increase performance through the exploitation of instruction-level parallelism (ILP). Previous studies have shown that speculative execution is required for high instruction per cycle (IPC) rates in non-numerical applications. The general trend has been toward supporting speculative execution in complicated, dynamically-scheduled processors. Performance, though, is more than just a high IPC rate; it also depends upon instruction count and cycle time. Boosting is an architectural technique that supports general speculative execution in simpler, statically-scheduled processors. Boosting labels speculative instructions with their control dependence information. This labelling eliminates control dependence constraints on instruction scheduling while still providng full dependence information to the hardware. We have incorporated boosting into a trace-based, global scheduling algorithm that exploits ILP without adversely affecting the instruction count of a program. We use this algorithm and estimates of the boosting hardware involved to evaluate how much speculative execution support is really necessary to achieve good performance. We find that a statically-scheduled superscalar processor using a minimal implementation of boosting can easily reach the performance of a much more complex dynamically-scheduled superscalar processor.
PET of EGFR Expression with an <sup>18</sup>F-Labeled Affibody Molecule (2012)

(18)F-FBEM-Cys-Z(EGFR:1907) is a novel protein scaffold-based PET probe for imaging EGFR overexpression of tumors, and its ability to differentiate tumors with high and low EGFR expression in vivo holds promise for future clinical translation.
Proposal for an Ultranarrow Passband Using Two Coupled Rings (2007)

We demonstrate theoretically that a simple two-coupled-ring structure yields very narrow resonances in the transmission spectra, provided the loss is very small. The linewidth is smallest when the path lengths of the two rings have a ratio of two. Relative to the single ring, the linewidth is reduced beyond the size scaling by the intensity buildup factor in the second ring. In the lossless case, the linewidth can be two orders of magnitude narrower. The enhancement can still be seen for experimentally demonstrated silicon-on-insulator microrings.
A lower esophageal sphincter reflex involving substance P (1984)

The purpose of this study was to determine the mechanism by which distal esophageal acidification increases lower esophageal sphincter (LES) pressure in the anesthetized cat. Intraluminal pressures and myoelectric activity were recorded using fixed, localized manometric catheters and serosal bipolar silver-silver chloride electrodes. The increase in LES pressure (27.1 +/- 4.9 mmHg) and spike activity (133.8 +/- 22.6 spikes/min) following distal esophageal acidification were greater than after saline (P less than 0.001). These responses were abolished by either tetrodotoxin (intravenously) or intraluminal ethyl aminobenzoate. The responses were not antagonized by bilateral cervical vagotomy or by atropine, hexamethonium, phentolamine, propranolol, diphenhydramine, cimetidine, cinanserin, naloxone, haloperidol, or proglumide. Tachyphylaxis to substance P abolished the LES pressure and spike responses to exogenous substance P and to distal esophageal acidification but had no effect on the LES responses to phenylephrine (25.0 micrograms/kg iv) or pentagastrin (0.5 microgram/kg iv). The putative substance P antagonist [D-Pro2,D-Trp7,9]substance P was a partial antagonist and a weak agonist on the LES. Large doses of [D-Pro2,D-TRP7,9]substance P (200.0 micrograms/kg iv) gave a 61.3 +/- 19.3% inhibition of the LES pressure response to acid (P less than 0.05). Intravenous tetrodotoxin partially antagonized the LES response to substance P (10.0 micrograms/kg iv). These studies suggest that the increases in LES pressure and spike activity following distal esophageal acidification occur through a spike-associated enteric neural reflex that involves substance P as a neurotransmitter.
Preparation and mechanical characterization of particleboard made from maritime pine and glued with bio-adhesives based on cornstarch and tannins (2010)

In this presented work, we describe the development and characterization of a new, environmentally friendly adhesive derived from cornstarch and tannins. The production of wood composites mainly relies on the petrochemical-based and formaldehyde-based adhesives such as urea formaldehyde (UF), phenol formaldehyde (PF) and melamine urea formaldehyde (MUF), which can generate under certain conditions, problems for health and environment. The aim of our work is to replace totally these synthetic resins. In order to evaluate the quality of cornstarch-tannin adhesives, particleboards were produced and physical and mechanical properties were investigated. These physical properties included rheological, thermogravimetric analysis and solid phase 13C NMR analysis of resins. Internal bond, surface soundness, modules of rupture and modulus of elasticity mechanical properties of particleboards bonded with cornstarch-tannin adhesives were also determined. Particleboards bonded with formaldehyde-free cornstarch-tannin adhesive showed comparable mechanical properties to the panels made with the commercial UF resins and satisfied the exigencies of panels for interior fittings used in dry medium (P2) according to European norms EN 312 (2004). Beyond 4 hours, rheological characterization show excellent structural stability of cornstarch-tannin adhesive.