gebhart/patrepeval huggingface dataset:
[Effect of hypoxia on dedifferentiation of mature adipocytes: an experimental study]. (2008)

Mature adipocytes may dedifferentiate into fibroblast-like cells under appropriate conditions.
REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB) (2018)

Rapid eye movement sleep behavior disorder (RBD) is a parasomnia, with abnormal dream-enacting behavior during the rapid eye movement (REM) sleep. RBD is either idiopathic or secondary to other neurologic disorders and medications. Dementia with Lewy bodies (DLB) is the third most common cause of dementia, and the typical clinical presentation is rapidly progressive cognitive impairment. RBD is one of the core features of DLB and may occur either in advance or simultaneously with the onset of DLB. The association between RBD with DLB is widely studied. Evidences suggest that both DLB and RBD are possibly caused by the shared underlying synucleinopathy. This review article discusses history, clinical manifestations, possible pathophysiologies, and treatment of DLB and RBD and provides the latest updates.
Predictability and Uncertainty in the Pleasure of Music: A Reward for Learning? (2019)

Music ranks among the greatest human pleasures. It consistently engages the reward system, and converging evidence implies it exploits predictions to do so. Both prediction confirmations and errors are essential for understanding one's environment, and music offers many of each as it manipulates interacting patterns across multiple timescales. Learning models suggest that a balance of these outcomes (i.e., intermediate complexity) optimizes the reduction of uncertainty to rewarding and pleasurable effect. Yet evidence of a similar pattern in music is mixed, hampered by arbitrary measures of complexity. In the present studies, we applied a well-validated information-theoretic model of auditory expectation to systematically measure two key aspects of musical complexity: predictability (operationalized as information content [IC]), and uncertainty (entropy). In Study 1, we evaluated how these properties affect musical preferences in 43 male and female participants; in Study 2, we replicated Study 1 in an independent sample of 27 people and assessed the contribution of veridical predictability by presenting the same stimuli seven times. Both studies revealed significant quadratic effects of IC and entropy on liking that outperformed linear effects, indicating reliable preferences for music of intermediate complexity. An interaction between IC and entropy further suggested preferences for more predictability during more uncertain contexts, which would facilitate uncertainty reduction. Repeating stimuli decreased liking ratings but did not disrupt the preference for intermediate complexity. Together, these findings support long-hypothesized optimal zones of predictability and uncertainty in musical pleasure with formal modeling, relating the pleasure of music listening to the intrinsic reward of learning.<b>SIGNIFICANCE STATEMENT</b> Abstract pleasures, such as music, claim much of our time, energy, and money despite lacking any clear adaptive benefits like food or shelter. Yet as music manipulates patterns of melody, rhythm, and more, it proficiently exploits our expectations. Given the importance of anticipating and adapting to our ever-changing environments, making and evaluating uncertain predictions can have strong emotional effects. Accordingly, we present evidence that listeners consistently prefer music of intermediate predictive complexity, and that preferences shift toward expected musical outcomes in more uncertain contexts. These results are consistent with theories that emphasize the intrinsic reward of learning, both by updating inaccurate predictions and validating accurate ones, which is optimal in environments that present manageable predictive challenges (i.e., reducible uncertainty).
Zoom: SSD-based Vector Search for Optimizing Accuracy, Latency and Memory (2018)

With the advancement of machine learning and deep learning, vector search becomes instrumental to many information retrieval systems, to search and find best matches to user queries based on their semantic similarities.These online services require the search architecture to be both effective with high accuracy and efficient with low latency and memory footprint, which existing work fails to offer. We develop, Zoom, a new vector search solution that collaboratively optimizes accuracy, latency and memory based on a multiview approach. (1) A "preview" step generates a small set of good candidates, leveraging compressed vectors in memory for reduced footprint and fast lookup. (2) A "fullview" step on SSDs reranks those candidates with their full-length vector, striking high accuracy. Our evaluation shows that, Zoom achieves an order of magnitude improvements on efficiency while attaining equal or higher accuracy, comparing with the state-of-the-art.
Dijk, J.J.M. van (2015), Estimating human trafficking worldwide: a multi-mode strategy. (2015)

In this article, the author presents the results of an in-depth analysis of the<br/>production of statistics by Eurostat on formally identified victims of trafficking<br/>in human beings in Europe. He concludes that the concept of an identified<br/>victim of trafficking in human beings has different meanings in different<br/>European Union member States and that the identification process is organized<br/>differently as well. On the basis of those regional results, he argues that<br/>statistics on the number of recorded victims of human trafficking cannot be<br/>used as a reliable measurement of the extent of trafficking in human beings in<br/>a country, neither in the European Union nor elsewhere. As follow-up to this<br/>critical assessment, the author argues in favour of a worldwide programme for the<br/>collection of survey-based estimates of human trafficking and, to that end, presents<br/>a methodological strategy combining various modes of data collection.<br/>Keynotes: identification of victims of trafficking in human beings, Eurostat,<br/>cross-country differences, dark number studies, multi-mode strategies.
Classification of weather situations on single color images (2008)

Present vision based driver assistance systems are designed to perform under good-natured weather conditions. However, limited visibility caused by heavy rain or fog strongly affects vision systems. To improve machine vision in bad weather situations, a reliable detection system is necessary as a ground base. We present an approach that is able to distinguish between multiple weather situations based on the classification of single monocular color images, without any additional assumptions or prior knowledge. The proposed image descriptor clearly outperforms existing descriptors for that task. Experimental results on real traffic images are characterized by high accuracy, efficiency, and versatility with respect to driver assistance systems.
Topological Localization Via Signals of Opportunity (2012)

We consider problems of localization, disambiguation, and mapping in a domain filled with signals-of-opportunity generated by transmitters. One or more (static or mobile) receivers utilize these signals and from them characterize the domain, localize, disambiguate, etc. The tools we develop are topological in nature, and rely on interpreting the problem as one of embedding the domain into a sufficiently high-dimensional space of signals via a signal profile function. Varying kinds of signal processing (TOA, TDOA, DOA, etc.) and discretization are addressed. Finally, we describe experiments that demonstrate the feasibility of these ideas in practice.
A Modified Hybrid RF Predistorter Linearizer for Ultra Wideband 5G Systems (2017)

The wide-bandwidth signal transmission is one of the requirements in upcoming 5G communication systems in its quest for high data rates. In this paper, a wideband hybrid RF/digital predistortion (HRF-DPD) linearization technique is reported to compensate for the nonlinearity of ultra-wideband power amplifier (PA) for 5G systems driven by carrier aggregated and wideband modulated signals. The proposed methodology is suitable for 5G PA design, since its power overhead and system bandwidth does not increase with an increase in signal bandwidth. Taking advantage of recent available digital signal processing solutions, the proposed method reduces hardware requirements of the conventional analog predistorter by alleviating the need of vector multiplier, branch line coupler, and delay lines. Such linear operations are controlled digitally, which provides flexibility in terms of digitally compensation of delay, gain and phase control of the signal. For establishing a proof of concept, HRF-DPD is implemented with ZX60V-82+ class AB PA and tested using a 100- and 50-MHz long term evolution-carrier aggregated (LTE-CA) signal at 2 GHz. Experimental results show that the wideband PA along with the proposed predistorter delivers an adjacent channel leakage ratio (ACLR) of -54 dBc with a cancellation of 30.6 dB for 100-MHz LTE-CA signal. With the proposed method PA, nonlinear distortion outside the 100-MHz band can be linearized leading to filter less architecture which provides 45-dBc ACLR performance.
<title>High-aspect-ratio trench etching</title> (1993)

A high aspect ratio (> 15:1), sub-micron, deep capacitor trench process is demonstrated in an 8 inch Applied Materials P5000E magnetically enhanced reactive ion etcher (MERIE) using HBr/NF<SUB>3</SUB>/He-O<SUB>2</SUB> chemistry. Through the insertion of ferro-magnetic sheet material into the pedestal, sub-micron trenches can be etched to depths greater than 10 micrometers , with etch rates > 6000 angstroms/min, uniformity < +/- 5%, profile uniformity 89 +/- 0.5 degree(s) and selectivity to oxide > 40:1. The importance of the wafer surface temperature on trench etch properties is established. Studies indicate that there is a threshold temperature below which the chosen recipe would need to be modified to produce satisfactory trenches.
Transformation of sound pressure level from the free field to the eardrum in the horizontal plane (1974)

Measurements of pressure transformation, azimuthal dependence, interaural level difference, and ear canal pressure distribution from 12 studies are brought together in a common framework. The pool of data covers 100 subjects, the majority male, measured in five countries over a 40-yr period. Logical procedures are developed to identify the surfaces which best fit these essentially three-dimensional distributions of data, making allowance for the many disparities between studies. Sheets of data are presented showing transformation to the eardrum, azimuthal dependence, and interaural difference as functions of frequency from 0.2 to 12 kHz at 45° intervals in azimuth. Other sheets show azimuthal dependence and interaural difference as functions of azimuth at 24 discrete frequencies. The logical procedures, data presentations, and review of disparities lead to the construction of self-consistent families of curves best fitting the data and showing the average sound pressure transformation from the free field to the human eardrum as a function of frequency at 15° intervals in azimuth. Possible explanations of differences between studies are suggested.
Application of hepatocyte-like cells to enhance hepatic safety risk assessment in drug discovery (2018)

Hepatic stress and injury from drugs continues to be a major concern within the pharmaceutical industry, leading to preclinical and clinical attrition precautionary warnings and post-market withdrawal of drugs. There is a requirement for more predictive and mechanistically accurate models to aid risk assessment. Primary human hepatocytes, subject to isolation stress, cryopreservation, donor-to-donor variation and a relatively short period of functional capability in two-dimensional cultures, are not suitable for high-throughput screening procedures. There are two areas within the drug discovery pipeline that the generation of a stable, metabolically functional hepatocyte-like cell with unlimited supply would have major impact. First, in routine, cell health risk-assessment assays where hepatic cell lines are typically deployed. Second, at later stages of the drug discovery pipeline approaching candidate nomination where bespoke/investigational studies refining and understanding the risk to patients use patient-derived induced pluripotent stem cell (iPSC) hepatocytes retaining characteristics from the patient, e.g. HLA susceptibility alleles, iPSC hepatocytes with defined disease phenotypes or genetic characteristics that have the potential to make the hepatocyte more sensitive to a particular stress mechanism. Functionality of patient-centric hepatocyte-like cells is likely to be enhanced when coupled with emerging culture systems, such as three-dimensional spheroids or microphysiological systems. Ultimately, the aspiration to confidently use human-relevant <i>in vitro</i> models to predict human-specific hepatic toxicity depends on the integration of promising emerging technologies.This article is part of the theme issue 'Designer human tissue: coming to a lab near you'.
Isolation of <i>Bartonella rattimassiliensis</i> sp. nov. and <i>Bartonella phoceensis</i> sp. nov. from European <i>Rattus norvegicus</i> (2004)

Thirty-three isolates of Bartonella spp., including 11 isolates not belonging to previously known species, were isolated from 66 Rattus norvegicus subjects trapped in the city of Marseille, France. Based on seven different gene sequences, the 11 isolates were assigned to Bartonella rattimassiliensis sp. nov. and Bartonella phoceensis sp. nov.
The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target (2019)

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibodies production and immune complex deposition with systemic clinical manifestations. Interleukin (IL)-17-producing cells play a crucial role in disease pathogenesis and represent an attractive therapeutic target. Areas covered: This review provides an update on the possibility of targeting IL-17 in SLE. The rational for this approach as well as currently available and future targets are discussed. Expert opinion: Although human expression studies and animal models indicate that IL-17 blocking may be a promising therapeutic strategy for SLE, direct evidence for IL-17 inhibition in SLE patients is unavailable. Biologic therapies and small-molecule drugs that target IL-17 production are required for the achievement of a favorable clinical effect in SLE patients.
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity (1994)

Ligation of the interleukin-7 receptor (IL-7R) results in a rapid phosphorylation of tyrosine residues on multiple substrates. In addition, we have recently shown that the IL-7R mediates activation of phosphatidylinositol-3 (PI-3) kinase. Because PI-3 kinase activity can be immunoprecipitated with antiphosphotyrosine antibodies in most receptor systems studied, it has been examined that either PI-3 kinase or an associated protein become tyrosine-phosphorylated after ligand binding. We studied here the possibility that PI-3 kinase, which is directly linked to mitogenic responses in growth factor receptors, is tyrosine-phosphorylated after stimulation of the IL-7R. Using anti-p85 alpha or anti-p85 beta antibodies raised against the p85 subunit of PI- 3 kinase for immunoprecipitation and subsequent blotting with antiphosphotyrosine clearly shows that IL-7-stimulated human precursor cells contain both p85 alpha and p85 beta proteins phosphorylated on tyrosine residues. Specific protein tyrosine kinase inhibitors such as tyrphostin AG-490 block total cell lysate phosphorylation and tyrosine phosphorylation on p85. Similar concentrations of this inhibitor also block in vitro and in vivo PI-3 kinase activity suggesting that this enzyme activation is dependent on the phosphorylation event of p85. In addition, AG-490 blocks IL-7-mediated proliferation in a dose-dependent manner, suggesting a link between the early events of PI-3 kinase phosphorylation and activation with IL-7R-induced cell growth.
Management of gout in the primary care setting (2022)

Gout is a commonly treated inflammatory arthritis that is often managed in the primary care setting. This disease is prevalent among the multi-ethnic Malaysian population. Unfortunately, gout is still frequently managed sub-optimally, even in the hospital and primary care settings. Gout should be considered a major disease since it can potentially lead to multiple disabilities from joint destruction, nephropathy and increased cardiovascular morbidity and mortality. The objectives of this review are to summarise the latest updated information and management of gout in the primary care setting.
A Load Adaptive Control Approach for a Zero-Voltage-Switching DC/DC Converter Used for Electric Vehicles (2011)

This paper presents a load adaptive control approach to optimally control the amount of reactive current required to guarantee zero-voltage switching (ZVS) of the converter switches. The proposed dc/dc converter is used as a battery charger for an electric vehicle (EV). Since this application demands a wide range of load variations, the converter should be able to sustain ZVS from full-load to no-load condition. The converter employs an asymmetric auxiliary circuit to provide the reactive current for the full-bridge semiconductor switches, which guarantees ZVS at turn-on times. The proposed control scheme is able to determine the optimum value of the reactive current injected by the auxiliary circuit in order to minimize extra conduction losses in the power MOSFETs, as well as the losses in the auxiliary circuit. In the proposed approach, the peak value of the reactive current is controlled by controlling the switching frequency to make sure that there is enough current to charge and discharge the snubber capacitors during the deadtime. In addition, some practical issues of this application (battery charger for an EV) are discussed in this paper. Experimental results for a 2-kW dc/dc converter are presented. The results show an improvement in efficiency and better performance of the converter.
Surface-Engineered PtNi-O Nanostructure with Record-High Performance for Electrocatalytic Hydrogen Evolution Reaction (2018)

Hydrogen holds the potential of replacing nonrenewable fossil fuel. Improving the efficiency of hydrogen evolution reaction (HER) is critical for environmental friendly hydrogen generation through electrochemical or photoelectrochemical water splitting. Here we report the surface-engineered PtNi-O nanoparticles with enriched NiO/PtNi interface on surface. Notably, PtNi-O/C showed a mass activity of 7.23 mA/μg at an overpotential of 70 mV, which is 7.9 times higher compared to that of the commercial Pt/C, representing the highest reported mass activity for HER in alkaline conditions. The HER overpotential can be lowered to 39.8 mV at 10 mA/cm<sup>2</sup> when platinum loading was only 5.1 μg<sub>pt</sub>/cm<sup>2</sup>, showing exceptional HER efficiency. Meanwhile, the prepared PtNi-O/C nanostructures demonstrated significantly improved stability as well as high current performance which are well over those of the commercial Pt/C and demonstrated capability of scaled hydrogen generation.
Low-power signal integrity trainings for multi-clock source-synchronous memory systems (2013)

Advanced high-speed multi-clock source-synchronous systems such as GDDR5 employ different trainings to ensure the signal integrity for high bandwidth applications. Through these trainings proper timing relationships among data and clocks are defined in the initialization phase. In this paper, a multi-clock synchronization training using phase interpolator (PI)-based phase-locked loop (PLL) architecture is proposed, which consumes 11.7 times less power and 27 times less area than other works. In addition, an adaptive equalization training is introduced for a GDDR5 memory system to compensate for inter-symbol interference (ISI). For the low power design, the equalizers are applied only in the memory controller utilizing the existing GDDR5 memory interface. This system architecture aimed of low-power design is verified by using least mean square (LMS) and pilot signal/peak detection. Results show that LMS algorithm improves the vertical and horizontal eye opening by more than 30% and 10%, respectively.
Vitamin B6 metabolism influences the intracellular accumulation of cisplatin (2013)

Vitamin B6 metabolism influences the adaptive response of non-small lung carcinoma (NSCLC) cells to distinct, potentially lethal perturbations in homeostasis, encompassing nutrient deprivation, hyperthermia, hypoxia, irradiation as well as the exposure to cytotoxic chemicals, including the DNA-damaging agent cisplatin (CDDP). Thus, the siRNA-mediated downregulation of pyridoxal kinase (PDXK), the enzyme that generates the bioactive form of vitamin B6, protects NSCLC cells (as well as a large collection of human and murine malignant cells of distinct histological derivation) from the cytotoxic effects of CDDP. Accordingly, the administration of pyridoxine, one of the inactive precursors of vitamin B6, exacerbates cisplatin-induced cell death, in vitro and in vivo, but only when PDXK is expressed. Conversely, antioxidants such as non-oxidized glutathione (GSH) are known to protect cancer cells from CDDP toxicity. Pyridoxine increases the amount of CDDP-DNA adducts formed upon the exposure of NSCLC cells to CDDP and aggravates the consequent DNA damage response. On the contrary, in the presence of GSH, NSCLC cells exhibit near-to-undetectable levels of CDDP-DNA adducts and a small fraction of the cell population activates the DNA damage response. We therefore wondered whether vitamin B6 metabolism and GSH might interact with CDDP in a pharmacokinetic fashion. In this short communication, we demonstrate that GSH inhibits the intracellular accumulation of CDDP, while pyridoxine potentiates it in a PDXK-dependent fashion. Importantly, such pharmacokinetic effects do not involve plasma membrane transporters that mediate a prominent fraction of CDDP influx, i.e., solute carrier family 31, member 1 (SLC31A1, best known as copper transporter 1, CTR1) and efflux, i.e., ATPase, Cu ( 2+) transporting, β polypeptide (ATP7B).
A Cloud-based Intrusion Detection Service framework (2012)

Intrusion Detection System (IDS) have become increasingly popular over the past years as an important network security technology to detect cyber attacks in a wide variety of network communication. IDS monitors' network or host system activities by collecting network information, and analyze this information for malicious activities. Cloud computing, with the concept of Software as a Service (SaaS) presents an exciting benefit when it enables providers to rent their services to users in perform complex tasks over the Internet. In addition, Cloud based services reduce a cost in investing new infrastructure, training new personnel, or licensing new software. In this paper, we introduce a novel framework based on Cloud computing called Cloud-based Intrusion Detection Service (CBIDS). This model enables the identification of malicious activities from different points of network and overcome the deficiency of classical intrusion detection. CBIDS can be implemented to detect variety of attacks in private and public Clouds.