gebhart/patrepeval huggingface dataset:
Induction and Autocrine Receptor Binding of Transforming Growth Factor-β2 during Terminal Differentiation of Primary Mouse Keratinocytes (1990)

Primary cultures of mouse keratinocytes maintain a basal cell phenotype in 0.05 mM Ca2+ medium, while culture in 1.4 mM Ca2+ results in terminal differentiation and inhibition of DNA synthesis. Induction of differentiation by Ca2+ results in a 10- to 20-fold increase in the expression of transforming growth factor-beta 2 (TGF-beta 2) mRNA and peptide, but a decrease in the expression of TGF-beta 1. In contrast, binding and cross-linking analyses show that the number of available surface 80 kilodalton (kDa) and 65 kDa TGF-beta receptor types decrease during differentiation. However, a mild acid wash significantly increases the number of available receptor sites on the differentiated keratinocytes, indicating that the TGF-beta receptors are unavailable for binding due to masking by endogenous ligand. A significant level of TGF-beta 2 secretion and receptor binding occur before the decrease in DNA synthesis, suggesting that the inhibition of DNA synthesis associated with differentiation of keratinocytes is mediated through the production and autocrine action of TGF-beta 2.
Phase II Study of Arsenic Trioxide Plus Ascorbic Acid for Relapsed and Refractory Lymphoid Malignancies: A Wisconsin Oncology Network Study. (2004)

Abstract Introduction: Arsenic trioxide (AT) has impressive single agent activity in relapsed acute promyelocytic leukemia. It also has activity in myelodysplastic syndromes and multiple myeloma. In vitro data has suggested increased cytotoxicity when combined with agents that deplete intracellular glutathione, forming the rationale for combination studies. Ascorbic acid (AA) can deplete intracellular glutathione and may potentiate the cytotoxicity of AT. Upon this basis, we initiated a phase II study of arsenic trioxide plus ascorbic acid for relapsed/refracory lymphoid malignancies. Arsenic trioxide was administered at a dose of 0.25 mg/kg IV over one hour M-F for one week and then 2X/week for 5 weeks. Each arsenic infusion was followed by an infusion of 1000 mg ascorbic acid over 15 minutes. Each 6-week cycle was followed by a two-week rest period before repeating the cycle. Treatment was continued until best response plus two cycles or progressive disease. Patient characteristics: Median age 70.5 (37–88). Gender 10M, 6F. Histologies CLL/SLL (4), Follicular (3), Mantle Cell (3), DLBCL (2), Burkitt (2), Marginal Zone (1), Hairy Cell (1). Median # Prior therapies 4 (2–13). Refractory to prior treatment 13/16. Median ECOG PS 1 (0–2). B symptoms 3/16. Elevated LDH 8/16. Elevated B2M 13/16. Results: Median number of completed cycles 1 (0–4). Eight patients did not complete cycle #1, six due to progressive disease (PD) and 2 due to toxicity. Of the 2 patients coming off for toxicity, one patient with known coronary artery disease suffered a myocardial infarction on the 4th day of treatment and expired from congestive heart failure and the other experienced repeated grade 4 hyperglycemia. Six patients completed one cycle of therapy and were removed for PD. One patient completed 3 cycles of therapy before experiencing PD. One patient with mantle cell lymphoma received 4 cycles of therapy and achieved a CRu. The overall response rate was 6% (1/16). The responding patient’s treatment was stopped after 4 cycles for MD/patient preference and she experienced PD 5 months after completion of therapy. Grade 3 toxicities included thrombocytopenia (2 patients), anemia (3), neutropenia (1), stomatitis (1), anorexia (1), and elevated LFTs (1). Grade 4 toxicities included neutropenia (2) and hyperglycemia (1). Conclusions: AT plus AA in this dosing schedule had modest toxicity but limited antitumor activity. The data should be interpreted in the context of our heavily treated, essentially refractory patient population. Our trial had a two-stage design, and was closed due to lack of activity at the first stage analysis. Other doses and schedules may prove to be more efficacious.
How to Render FDTD Computations More Effective Using a Graphics Accelerator (2009)

Graphics processing units (GPUs) for years have been dedicated mostly to real time rendering. Recently leading GPU manufactures have extended their research area and decided to support also graphics computing. In this paper, we describe an impact of new GPU features on development process of an efficient finite difference time domain (FDTD) implementation.
Pharmacological characterization of [<sup>3</sup>H]‐prostaglandin E<sub>2</sub> binding to the cloned human EP<sub>4</sub> prostanoid receptor (2000)

Prostaglandin (PG) E(2) (PGE(2)) is a potent prostanoid derived from arachidonic which can interact with EP(1), EP(2), EP(3) and EP(4) prostanoid receptor subtypes. Recombinant human EP(4) receptors expressed in human embryonic kidney (HEK-293) cells were evaluated for their binding characteristics using [(3)H]-PGE(2) and a broad panel of natural and synthetic prostanoids in order to define their pharmacological properties. [(3)H]-PGE(2) binding was optimal in 2-[N-Morpholino]ethanesulphonic acid (MES) buffer (pH 6.0) yielding 98+/-0.7% specific binding. The receptor displayed high affinity (K(d)=0.72+/-0.12 nM; n=3) for [(3)H]-PGE(2) and interacted with a saturable number of binding sites (B(max)=6.21+/-0.84 pmol mg(-1) protein). In competition studies, PGE(2) (K(i)=0.75+/-0.03 nM; n=12) and PGE(1) (K(i)=1.45+/-0.24 nM; n=3) displayed high affinities, as did two derivatives of PGE(1), namely 11-deoxy-PGE(1) (K(i)=1.36+/-0.34 nM) and 13,14-dihydro-PGE(1) (K(i)=3.07+/-0.29 nM). Interestingly, synthetic DP receptor-specific agonists such as BW245C (K(i)=64.7+/-1.0 nM; n=3) and ZK118182 (K(i)=425+/-42 nM; n=4), and the purported EP(3) receptor-specific ligand enprostil (K(i)=43.1+/-4.4 nM), also displayed high affinity for the EP(4) receptor. Two known EP(4) receptor antagonists were weak inhibitors of [(3)H]-PGE(2) binding akin to their known functional potencies, thus: AH23848 (K(i)=2690+/-232 nM); AH22921 (K(i)=31,800+/-4090 nM). These studies have provided a detailed pharmacological characterization of the recombinant human EP(4) receptor expressed in HEK-293 cells.
DELTA: Data Extraction and Logging Tool for Android (2017)

In recent years, the use of smartphones has increased exponentially, and so have their capabilities. Together with an increase in processing power, smartphones are now equipped with a variety of sensors and provide an extensive set of API. These capabilities allow us to extract data related to environment, user habits, and operating system itself. This data is extremely valuable in many research fields such as user authentication, intrusion, and information leaks detection. For these reasons, researchers need a solid and reliable logging tool to collect data from mobile devices. In this paper, we first survey the existing logging tools available on the Android platform, comparing their features and their impact on the system. Then, we present DELTA - Data Extraction and Logging Tool for Android, which improves the existing Android logging solutions in terms of flexibility, fine-grained tuning capabilities, extensibility, and available set of logging features. We fully implement DELTA and we run a thorough performance evaluation. The results show that our tool has a low impact on the performance of the system, on battery consumption, and on user experience. Finally, we make the DELTA source code available to the research community.
High Capability Error Correction LSI for CD Player and CD Rom (1984)

While the Compact Disc (CD) players have been gradually spread, a higher- performance for the error correction capability has been required in order to protect reproduced audio signals against errors due to scratches, finger prints etc. on a disc. On the other hand, the CD player have been given attention as a data file system, which provides a lower cost, more capacity and reliability than a conventional data file such as floppy disc system and so on. In order to apply a CD player to such a data file system what is called "CD ROM", an improvement of the error correction capability is also required.
openEyes: an open-hardware open-source system for low-cost eye tracking (2006)

Eye tracking has long held the promise of being a useful methodology for human computer interaction. However, a number of barriers have stood in the way of the integration of eye tracking into everyday applications, including the intrusiveness, robustness, availability and price of eye-tracking systems. To lower these barriers, we have developed the openEyes system. The system consists of an open-hardware design for a digital eye tracker that can be built from low-cost off-the-shelf components, and a set of open-source software tools for digital image capture, manipulation, and analysis in eye-tracking applications. We expect that the availability of this system will facilitate the development of eye-tracking applications and the eventual integration of eye tracking into the next generation of everyday human computer interfaces. We discuss the methods and technical challenges of low-cost eye tracking as well as the design decisions that produced our current system.
Cyclopolymerization. VI. Preparation and Properties of Crosslinked Polyamines by Cyclopolymerization (1976)

Abstract Crosslinked polymer and copolymers containing tertiary amino groups were prepared from a number of allylamino monomers by cyclopolymerization. The effects of the initiator residue, reaction conditions, monomer structure, and degree of crosslinking on specific properties such as ion-exchange capacity, pKa, and range of nitrogen basicities were investigated.
Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase (1998)

The Expressed Sequence Tag database has been screened for cDNA clones encoding prostaglandin D2 synthases (PGDSs) by using a BLAST search with the N-terminal amino acid sequence of rat GSH-dependent PGDS, a class Sigma glutathione S-transferase (GST). This resulted in the identification of a cDNA from chicken spleen containing an insert of approx. 950 bp that encodes a protein of 199 amino acid residues with a predicted molecular mass of 22732 Da. The deduced primary structure of the chicken protein was not only found to possess 70% sequence identity with rat PGDS but it also demonstrated more than 35% identity with class Sigma GSTs from a range of invertebrates. The open reading frame of the chicken cDNA was expressed in Escherichia coli and the purified protein was found to display high PGDS activity. It also catalysed the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls, and exhibited glutathione peroxidase activity towards cumene hydroperoxide. Like other GSTs, chicken PGDS was found to be inhibited by non-substrate ligands such as Cibacron Blue, haematin and organotin compounds. Western blotting experiments showed that among the organs studied, the expression of PGDS in the female chicken is highest in liver, kidney and intestine, with only small amounts of the enzyme being found in chicken spleen; in contrast, the rat has highest levels of PGDS in the spleen. Collectively, these results show that the structure and function, but not the expression, of the GSH-requiring PGDS is conserved between chicken and rat.
Cryogenic amplifier for ∼1 MHz with a high input impedance using a commercial pseudomorphic high electron mobility transistor (2004)

A cryogenic amplifier for ∼100 kHz to a few MHz is presented which uses a commercially available pseudomorphic GaAs/InGaAs high electron mobility transistor and dissipates less than 0.5 mW in the cryogenic stage. The input-referred voltage noise and current noise of the amplifier at approximately 2 MHz are measured to be approximately 0.7 nV Hz−1/2 and 25 fA Hz−1/2, respectively. A superconducting resonant circuit can be used to provide a high input impedance over a narrow bandwidth, or a low input impedance can be used to yield a large bandwidth. Although suitable for many applications, the amplifier has been developed for measurements of current noise from a high-impedance source, and its long-term stability is such that by averaging over 30 min, it could be used to detect approximately 0.6 fA Hz−1/2.
BIIE0246, a potent and highly selective non‐peptide neuropeptide Y Y<sub>2</sub> receptor antagonist (2000)

1. BIIE0246, a newly synthesized non-peptide neuropeptide Y (NPY) Y(2) receptor antagonist, was able to compete with high affinity (8 to 15 nM) for specific [(125)I]PYY(3 - 36) binding sites in HEK293 cells transfected with the rat Y(2) receptor cDNA, and in rat brain and human frontal cortex membrane homogenates. 2. Interestingly, in rat brain homogenates while NPY, C2-NPY and PYY(3 - 36) inhibited all specific [(125)I]PYY(3 - 36) labelling, BIIE0246 failed to compete for all specific binding suggesting that [(125)I]PYY(3 - 36) recognized, in addition to the Y(2) subtype, another population of specific NPY binding sites, most likely the Y(5) receptor. 3. Quantitative receptor autoradiographic data confirmed the presence of [(125)I]PYY(3 - 36)/BIIE0246-sensitive (Y(2)) and-insensitive (Y(5)) binding sites in the rat brain as well as in the marmoset monkey and human hippocampal formation. 4. In the rat vas deferens and dog saphenous vein (two prototypical Y(2) bioassays), BIIE0246 induced parallel shifts to the right of NPY concentration-response curves with pA(2) values of 8.1 and 8.6, respectively. In the rat colon (a Y(2)/Y(4) bioassay), BIIE0246 (1 microM) completely blocked the contraction induced by PYY(3 - 36), but not that of [Leu(31), Pro(34)]NPY (a Y(1), Y(4) and Y(5) agonist) and hPP (a Y(4) and Y(5) agonist). Additionally, BIIE0246 failed to alter the contractile effects of NPY in prototypical Y(1) in vitro bioassays. 5. Taken together, these results demonstrate that BIIE0246 is a highly potent, high affinity antagonist selective for the Y(2) receptor subtype. It should prove most useful to establish further the functional role of the Y(2) receptor in the organism.
Brain-computer interface using P300: a gaming approach for neurocognitive impairment diagnosis (2016)

This paper proposes a novel mobile healthcare system for remotely monitoring neuro-cognitive functions of impaired subjects and proposing possible treatments. Currently, only hospital centers perform similar analyses through fixed and wired electroencephalography (EEG) inspection. The solution proposed here works wirelessly and improves its accuracy learning by performances of the subject playing a game/test. The system is based on spatio-temporal detection and characterization of a specific brain potential named P300. It includes: i) a wearable wireless EEG device; ii) a gateway (tablet or smartphone) processing gathered data, also providing the test/game to the user. Given the above hardware settings, a new algorithm, named tuned-Residue Iteration Decomposition (t-RIDE), provides spatiotemporal features of P300s and a semantic-based reasoner allows taking into account factors which could modify the test if performed in non-standard conditions. The system has been adopted with 12 subjects involved in three different cognitive tasks with increasing difficulty. Fast diagnosis of cognitive deficits is reached, including mild and heavy impairments cases: t-RIDE processing is performed in 1.95s (after 79 iterations for convergence) whereas semantic matchmaking routine requires 2.5ms in the worst case. A case study for an Alzheimer injured patient is reported to corroborate and clarify the proposed approach.
Coronavirus Disease 2019 (COVID-19) Pandemic and Economic Impact (2020)

In less than two decades, the world has experienced three outbreaks of deadly Coronaviruses, including the recent pandemic of Coronavirus Disease 2019 (COVID-19) in China. COVID-19 posed an emergency of international concerns, and cases have been reported in more than 200 countries/regions that resulted in health, lives, and economic losses. China's economic growth is projected to fall to 5.6% this year, the International Monetary Fund (IMF) projected that policy investment and tax policies to implement $3.3 trillion and contributes further $4.5 trillion. IMF forecasts grow from 3.7% of global gross domestic product (GDP) in 2019 to 9.9% in 2020. GDP ratio projected from 3.0% in 2019 to grow 10.7% in 2020, the US ratio expected to increase from 5.8% to 15.7%. France, Germany, Italy, Japan, and the United Kingdom (UK) each reported public sector funding programs totalling > 10% of their yearly GDP. There is a dire need for regional and international co-operation to extend hands to prevent further spreading of COVID-19.
A two-stage approach to detect abandoned baggage in public places (2010)

Baggage abandoned in public places can pose a serious security threat. In this paper a two-stage approach that works on video sequences captured by a single immovable CCTV camera is presented. At first, foreground objects are segregated from static background objects using brightness and chromaticity distortion parameters estimated in the RGB colour space. The algorithm then locks on to binary blobs that are static and of 'bag' sizes; the size constraints used in the scheme are chosen based on empirical data. Parts of the background frame and current frames covered by a locked mask are then tracked using a 1-D (unwrapped) pattern generated using a bi-variate frequency distribution in the rg chromaticity space. Another approach that uses edge maps instead of patterns generated using the fragile colour information is discussed. In this approach the pixels that are part of an edge are marked using a novel scheme that utilizes four 1-D Laplacian kernels; tracking is done by calculating the total entropy in the intensity images in the sections encompassed by the binary edge maps. This makes the process broadly illumination invariant. Both the algorithms have been tested on the iLIDS dataset (produced by the Home Office Scientific Development Branch in partnership with Security Service, United Kingdom) and the results obtained are encouraging.
The Making of a Macromolecular Machine: Assembly of the Membrane Attack Complex (2014)

The complement terminal pathway clears pathogens by generating cytotoxic membrane attack complex (MAC) pores on target cells. For more than 40 years, biochemical and cellular assays have been used to characterize the lytic nature of the MAC and to define its protein composition. Although models for pore formation have been inferred from structures of bacterial cytolysins, it was only recently that we were able to visualize how complement components come together during MAC assembly. This review highlights structural analyses of terminal pathway complexes to explore molecular mechanisms underlying MAC formation.
Darius The Mede (Person) (1992)

[Heb dārĕyāwaeš mādājāʾ]. The Median Darius was a 62-year-old man who, as predicted by Daniel, gained control over the Chaldean kingdom immediately following the death of Belshazzar (Dan 5:28–6:2). His first action as king was to set 120 satraps over the kingdom. On the king’s behalf, but against hi
Recommendations for Transport-Protocol Port Randomization (2011)

During the last few years, awareness has been raised about a number of "blind" attacks that can be performed against the Transmission Control Protocol (TCP) and similar protocols. The consequences of these attacks range from throughput reduction to broken connections or data corruption. These attacks rely on the attacker's ability to guess or know the five-tuple (Protocol, Source Address, Destination Address, Source Port, Destination Port) that identifies the transport protocol instance to be attacked. This document describes a number of simple and efficient methods for the selection of the client port number, such that the possibility of an attacker guessing the exact value is reduced. While this is not a replacement for cryptographic methods for protecting the transport-protocol instance, the aforementioned port selection algorithms provide improved security with very little effort and without any key management overhead. The algorithms described in this document are local policies that may be incrementally deployed and that do not violate the specifications of any of the transport protocols that may benefit from them, such as TCP, UDP, UDP-lite, Stream Control Transmission Protocol (SCTP), Datagram Congestion Control Protocol (DCCP), and RTP (provided that the RTP application explicitly signals the RTP and RTCP port numbers).
Henry Smeathman, the Fly-Catching Abolitionist (2004)

In his landmark study, The Problem of Slavery in the Age of Revolution, 1770–1823 (1975), David Brion Davis linked the first two decades of the anti-slavery movement to increasing domestic concern in Britain about the problems of under-employment, labour discipline, and labour management. Scrutinizing the writings of many leading abolitionists, including prominent Quakers, Davis argues that they were less concerned with how emancipated slaves might express their capacity for freedom than with devising substitute schemes for the labour discipline of slavery.1 This essay examines the imperial dream, popular with some abolitionists, of making the transatlantic slave trade redundant by setting up free plantations in Africa to raise West Indian crops. While the aim of this scheme was to end slavery by undermining the sugar islands’ economy, there were of course commercial motives for developing Africa’s rich natural resources. Furthermore, linked to these commercial prospects were speculations on both sides of the slavery debate as to how Africa might compensate Britain for the financial loss of its American colonies.
CHARACTERIZATION OF BULK SOIL HUMIN AND ITS ALKALINE-SOLUBLE AND ALKALINE-INSOLUBLE FRACTIONS (2015)

Humic substances are the major components of soil organic matter. Among the three humic substance components (humic acid, fulvic acid, and humin), humin is the most insoluble in aqueous solution at any pH value and, in turn, the least understood. Humin has poor solubility mainly because it is tightly bonded to inorganic soil colloids. By breaking the linkage between humin and inorganic soil colloids using inorganic or organic solvents, bulk humin can be partially soluble in alkali, enabling a better understanding of the structure and properties of humin. However, the structural relationship between bulk humin and its alkaline-soluble (AS) and alkaline-insoluble (AIS) fractions is still unknown. In this study, we isolated bulk humin from two soils of Northeast China by exhaustive extraction (25 to 28 times) with 0.1 mol L-1 NaOH + 0.1 mol L-1 Na4P2O7, followed by the traditional treatment with 10 % HF-HCl. The isolated bulk humin was then fractionated into AS-humin and AIS-humin by exhaustive extraction (12 to 15 times) with 0.1 mol L-1 NaOH. Elemental analysis and solid-state 13C cross-polarization magic angle spinning nuclear magnetic resonance (13C CPMAS NMR) spectroscopy were used to characterize and compare the chemical structures of bulk humin and its corresponding fractions. The results showed that, regardless of soil types, bulk humin was the most aliphatic and most hydrophobic, AS-humin was the least aliphatic, and AIS-humin was the least alkylated among the three humic components. The results showed that bulk humin and its corresponding AS-humin and AIS-humin fractions are structurally differed from one another, implying that the functions of these humic components in the soil environment differed.