gebhart/patrepeval huggingface dataset:
Acides gras ω-3 et troubles psychiatriques (2005)

The brain is one of the organs with the highest level of lipids (fats). Brain lipids, formed of fatty acids, participate in the structure of membranes, for instance 50 % fatty acids are polyunsaturated in the gray matter, 1/3 are of the omega-3 family, and are thus of dietary origin. The omega-3 fatty acids (mainly alpha-linolenic acid, ALA) participated in one of the first experimental demonstration of the effect of dietary substances (nutrients) on the structure and function of the brain. Experiments were first of all carried out on ex vivo cultured brain cells, then on in vivo brain cells (neurons, astrocytes and oligodendrocytes) from animals fed ALA deficient diet, finally on physicochemical (membrane fluidity), biochemical, physiological, neurosensory (vision an auditory responses), and behavioural or learning parameters. These findings indicated that the nature of polyunsaturated fatty acids (in particular omega-3) present in formula milks for human infants determines to a certain extend the visual, neurological, and intellectual abilities. Thus, in view of these results and of the high polyunsaturated fatty acid content of the brain, it is normal to consider that they could be involved in psychiatric diseases and in the cognitive decline of ageing. Omega-3 fatty acids appear effective in the prevention of stress, however their role as regulator of mood is a matter for discussion. Indeed, they play a role in the prevention of some disorders including depression (especially post partum), as well as in dementia, particularly Alzheimer's disease. Their role in major depression and bipolar disorder (manic-depressive disease), only poorly documented, is not clearly demonstrated. The intervention of omega-3 in dyslexia, autism, and schizophrenia has been suggested, but it does not necessarily infer a nutritional problems. The respective importance of the vascular system (where the omega-3 are actually active) and the cerebral parenchyma itself, remain to be resolved. However, the insufficient supply of omega-3 fatty acids in today diet in occidental (less than 50 % of the recommended dietary intakes values for ALA) raises the problem of how to correct inadequate dietary habits, by prescribing mainly rapeseed (canola) and walnut oils on the one hand, fatty fish (wild, or farmed, but the nature of fatty acids present in fish flesh is the direct consequence of the nature of fats with which they have been fed), and eggs from laying hens fed omega-3 fatty acids.
Effects of Chronic Treatment With <scp>l</scp> -Arginine on Atherosclerosis in ApoE Knockout and ApoE/Inducible NO Synthase Double-Knockout Mice (2003)

Although L-arginine supplementation does not affect lesion formation in the western-type diet-fed apoE ko mice, it negates the protective effect of iNOS gene deficiency in this model. This raises the possibility that L-arginine supplementation may paradoxically contribute to, rather than reduce, lesion formation by mechanisms that involve lipid oxidation, peroxynitrite formation, and NOS uncoupling.
Noninvasive optical measures of CBV, StO <sub>2</sub> , CBF index, and rCMRO <sub>2</sub> in human premature neonates' brains in the first six weeks of life (2009)

With the causes of perinatal brain injuries still unclear and the probable role of hemodynamic instability in their etiology, bedside monitoring of neonatal cerebral hemodynamics with standard values as a function of age are needed. In this study, we combined quantitative frequency domain near infrared spectroscopy (FD-NIRS) measures of cerebral tissue oxygenation (StO(2)) and cerebral blood volume (CBV) with diffusion correlation spectroscopy (DCS) measures of a cerebral blood flow index (CBF(ix)) to test the validity of the CBV-CBF relationship in premature neonates and to estimate cerebral metabolic rate of oxygen (rCMRO(2)) with or without the CBF(ix) measurement. We measured 11 premature neonates (28-34 weeks gestational age) without known neurological issues, once a week from one to six weeks of age. In nine patients, cerebral blood velocities from the middle cerebral artery were collected by transcranial Doppler (TCD) and compared with DCS values. Results show a steady decrease in StO(2) during the first six weeks of life while CBV remains stable, and a steady increase in CBF(ix). rCMRO(2) estimated from FD-NIRS remains constant but shows wide interindividual variability. rCMRO(2) calculated from FD-NIRS and DCS combined increased by 40% during the first six weeks of life with reduced interindividual variability. TCD and DCS values are positively correlated. In conclusion, FD-NIRS combined with DCS offers a safe and quantitative bedside method to assess CBV, StO(2), CBF, and rCMRO(2) in the premature brain, facilitating individual follow-up and comparison among patients. A stable CBV-CBF relationship may not be valid for premature neonates.
A meta-analysis of Parkinson's disease and exposure to pesticides. (2000)

This study examined the association between Parkinson's disease (PD) and exposure to pesticides. A series of meta-analysis of peer-reviewed studies were performed, using 19 studies published between 1989 and 1999. Prior to the meta-analysis, all studies were reviewed and evaluated for heterogeneity and publication bias. Significant heterogeneity among studies was detected and combined odds ratio (OR) was calculated using the random effect model. The majority of the studies reported consistent elevation in the risk of PD with exposure to pesticides. The combined OR studies was 1.94 [95% confidence interval (95% CI) 1.49-2.53] for all the studies, and 2.15 (95% CI 1.14-4.05) for studies performed in United States. Although the risk of PD increased with increased duration of exposure to pesticides, no significant dose-response relation was established, and no specific type of pesticide was identified. Our findings suggest that exposure to pesticides may be a significant risk factor for developing PD.
A Hybrid Communication Scheme for Efficient and Low-Cost Deployment of Future Flying Ad-Hoc Network (FANET) (2019)

In recent years, FANET-related research and development has doubled, due to the increased demands of unmanned aerial vehicles (UAVs) in both military and civilian operations. Equipped with more capabilities and unique characteristics, FANET is able to play a vital role in mission-critical applications. However, these distinctive features enforce a series of guidelines to be considered for its efficient deployment. Particularly, the use of FANET for on-time data communication services presents demanding challenges in terms of energy efficiency and quality of service (QoS). Proper use of communication architecture and wireless technology will assist to solve these challenges. Therefore, in this paper, we review different communication architectures, including the existing wireless technologies, in order to provide seamless wireless connectivity. Based on the discussions, we conclude that a multi-layer UAV ad-hoc network is the most suitable architecture for networking a group of heterogeneous UAVs, while Bluetooth 5 (802.15.1) is the most favored option because of its low-cost, low power consumption, and longer transmission range for FANET. However, 802.15.1 has the limitation of a lower data rate as compared to Wi-Fi (802.11). Therefore, we propose a hybrid wireless communication scheme so as to utilize the features of the high data transmission rate of 802.11 and the low-power consumption of 802.15.1. The proposed scheme significantly reduces communication cost and improves the network performance in terms of throughput and delay. Further, simulation results using the Optimized Network Engineering Tool (OPNET) further support the effectiveness of our proposed scheme.
Expression of the transformation-sensitive protein "cyclin" in normal human epidermal basal cells and simian virus 40-transformed keratinocytes. (1984)

A cell population highly enriched in human epidermal basal cells has been obtained and characterized by using antibodies specific for various cell types in the epidermis. Quantitative two-dimensional gel electrophoretic analysis (isoelectric focusing) of [35S]methionine-labeled polypeptides from basal cells and simian virus 40-transformed keratinocytes showed that the basal cells synthesize very low amounts (less than 0.02% of the total protein) of the nuclear, transformation-sensitive protein cyclin as compared to the transformed cells, which synthesize this protein constitutively (0.15% of the total protein). Very low levels of cyclin were observed in total human epidermis, and preliminary studies of two basaliomas have shown a significant synthesis of this protein in these tumors. Immunofluorescence studies using antibodies to proliferating cell nuclear antigen that immunoprecipitate cyclin confirmed the above observations at least in the case of the cultured cells. Taken together, these results support the notion that cyclin may be a central component of the pathway(s) that controls cell proliferation.
Accuracy Enhancement of RSSI-based Distance Estimation by Applying Gaussian Filter (2016)

RSSI values of Bluetooth Low Energy (BLE) beacon are unreliable to use localization. To cope with this problem, we propose a new localization algorithm that enhances the accuracy of RSSI value. The proposed algorithm applies Gaussian filter to RSSI values from BLE Beacons, and then uses weight value based on filtered RSSI quality. Background/Objectives: Friis formula is used to calculate distance between a BLE beacon and BLE scanners using triangulation scheme. Finally, Gaussian filtering is applied twice to the location values for accuracy improvement. Findings: Experiments are performed in indoor environment, and experiment data is calculated by MATLAB to make graph and chart for easily comparing location result. Experiment result shows that DGF algorithm shows more accurate and reliable localization result than commonly used Kalman filter algorithm. Furthermore, DGF algorithm is very effective to calculate not only distance but also location. Improvements: DGF algorithm indicates excellent performance when we adapt weight value. The proposed system can be used to tracking the location of BLE beacon in real-time. Keywords: Bluetooth, Beacon, DGF, Localization, RSSI
Biochemistry Involving Carbon-Fluorine Bonds (1976)

The development of site specific reagents necessarily depends on the knowledge of specific biochemical reactions, which should include the chemical structure of catalysts, substrates, modifiers, and products of enzymatic processes. Very little is known about catalytic sites of most enzymes, therefore comparison of substrates with analogues may be one of the experimental approaches to study this problem. It follows also that extensive information related to analytical enzymology (i.e., catalytic properties of isolated enzymes, enzymatic composition of cells) has to preceed the meaningful application of specific probes in complex systems. This endeavor is conceptually a synthetic one and intends to elucidate biological functions. It is only in relatively rare cases that inhibitors of cellular systems act in a manner predicted from in vitro enzymology. For example, a linear multienzymatic process can be indeed regulated by a rate limiting enzymatic component, susceptible to a specific inhibitor. In this case the biological significance
Lifetime Improvement of BaMgAl<sub>10</sub>O<sub>17</sub>:Eu<sup>2+</sup>Phosphor by Hydrogen Plasma Treatment (2009)

The effects of plasma treatment on the luminescence properties of BaMgAl10O17:Eu2+ (BAM:Eu2+) are investigated. Among argon-based plasmas with hydrogen or oxygen, it is confirmed that the addition of hydrogen to an argon plasma markedly improves the lifetime of BAM:Eu2+. The obtained results reveal that the oxidized Eu ions are reduced by a hydrogen plasma. Furthermore, it is found that the stability of the BAM host is also improved. As a result, BAM:Eu2+ phosphor has a higher resistance against (Ne+Xe) plasma irradiation. This new method of plasma processing for blue phosphor is applicable to the fabrication of plasma displays.
Efficacy of Low Doses of the Polyethylene Glycol Derivative of Interleukin-2 in Modulating the Immune Response of Patients with Human Immunodeficiency Virus Type 1 Infection (1993)

Interleukin-2 (IL-2) is a key cytokine in cellular immunity. Human immunodeficiency virus type 1 (HIV-1)-infected individuals lack IL-2 because of low CD4+ T lymphocyte numbers. In an attempt to enhance cellular immunity, low-dose recombinant human (rh) IL-2 at 10 micrograms or 180,000 units or its polyethylene glycol (PEG) derivative at 9 micrograms or 36,000 units was given by intracutaneous injection to 8 HIV-1-infected men for 30 days. Participants had no evidence of opportunistic infection and received concurrent zidovudine. IL-2 treatment was nontoxic and elicited a local cellular response resembling classic delayed-type hypersensitivity (DTH) with local interferon-gamma production, even in anergic patients. Systemic responses included enhanced DTH responses to recall antigens, improved in vitro proliferative responses to mitogen, and enhanced NK cell activity. Peripheral leukocyte phenotype and virus titers were unchanged. Long-term studies of low-dose IL-2 are warranted to determine whether immunoenhancing effects can be sustained and if they are associated with improved clinical course.
Large-Amplitude Dithering Mitigates Glitches in Digital-to-Analogue Converters (2020)

Glitches introduce impulse-like disturbances which are not be readily attenuated by low-pass filtering. This article presents a model that describes the behaviour of glitches, and a method for mitigation based on a large-amplitude dither signal. Analytical and experimental results demonstrate that a dither signal with sufficient amplitude can mitigate the effect of glitches, when used in conjunction with a low-pass filter. The dither signal in conjunction with low-pass filtering essentially converts a glitch from a high-frequency to low-frequency disturbance.
Automated classifier generation for application-level mobile traffic identification (2012)

This paper proposes an automated classifier generation system for application-level mobile traffic identification. The proposed system comprises traffic classifier generation system architecture and mobile traffic measurement agents (mTMAs) that are installed on mobile devices to monitor their application-level traffic. To generate classifiers, our adaptive algorithm selects the lowest cost classifiers from among the available classifier candidates, while assuring acceptable identification accuracy. To verify the efficacy of the proposed identification system, we implemented and deployed it on a campus network. The results of mobile application traffic identification obtained using the system in this deployment are also presented in this paper.
Environmental Noise Retards Auditory Cortical Development (2003)

The mammalian auditory cortex normally undergoes rapid and progressive functional maturation. Here we show that rearing infant rat pups in continuous, moderate-level noise delayed the emergence of adultlike topographic representational order and the refinement of response selectivity in the primary auditory cortex (A1) long beyond normal developmental benchmarks. When those noise-reared adult rats were subsequently exposed to a pulsed pure-tone stimulus, A1 rapidly reorganized, demonstrating that exposure-driven plasticity characteristic of the critical period was still ongoing. These results demonstrate that A1 organization is shaped by a young animal's exposure to salient, structured acoustic inputs-and implicate noise as a risk factor for abnormal child development.
Mechanisms of SOD1 regulation by post-translational modifications (2019)

SOD1 is commonly known for its ROS scavenging activity, but recent work has uncovered additional roles in modulating metabolism, maintaining redox balance, and regulating transcription. This new paradigm of expanded SOD1 function raises questions regarding the regulation of SOD1 and the cellular partitioning of its biological roles. Despite decades of research on SOD1, much of which focuses on its pathogenic role in amyotrophic lateral sclerosis, relatively little is known about its regulation by post-translational modifications (PTMs). However, over the last decade, advancements in mass spectrometry have led to a boom in PTM discovery across the proteome, which has also revealed new mechanisms of SOD1 regulation by PTMs and an array of SOD1 PTMs with high likelihood of biological function. In this review, we address emerging mechanisms of SOD1 regulation by post-translational modifications, many of which begin to shed light on how the various functions of SOD1 are regulated within the cell.
Viscosity as Related to Dietary Fiber: A Review (2006)

Viscosity is a physicochemical property associated with dietary fibers, particularly soluble dietary fibers. Viscous dietary fibers thicken when mixed with fluids and include polysaccharides such as gums, pectins, psyllium, and beta-glucans. Although insoluble fiber particles may affect viscosity measurement, viscosity is not an issue regards insoluble dietary fibers. Viscous fibers have been credited for beneficial physiological responses in human, animal, and animal-alternative in vitro models. The following article provides a review of viscosity as related to dietary fiber including definitions and instrumentation, factors affecting viscosity of solutions, and effects of viscous polysaccharides on glycemic response, blood lipid attenuation, intestinal enzymatic activity, digestibility, and laxation.
A method of medical ultrasonic image denoising and enhancement based on wavelet transform (2006)

Objective A method of medical ultrasonic images denoising and enhancement based on wavelet transform is explored. Methods A integrated speckle suppression method for medical ultrasound image based on wavelet transform was presented. Firstly, logarithmic transform was carried out to the medical ultrasound image. Multiplicative noises were transformed into additive ones. Secondly, the image was decomposed into low frequency and high frequency sub-band images by wavelet transform. Nonlinear soft threshold denoising and enhancement were carried out to the multiscale high frequency sub-band images. Finally, the inverse wavelet transform and the exponential transform were processed. Results The speckle noises in the original image were removed efficiently and the image edge details were reserved. Conclusion The method is efficiently to denoising speckle noises and reserving edge details in medical ultrasonic image.
Differential Effects of Radical Scavengers on X-Ray-Induced Mutation and Cytotoxicity in Human Cells (1987)

The cytotoxic and mutagenic effects of X irradiation on a human lymphoblast cell line were examined in the presence of two radioprotective agents which modulate damage to DNA. The cells were treated with X rays alone or in the presence of either dimethyl sulfoxide or cysteamine. Surviving fraction and mutation to trifluorothymidine resistance (tk locus) and to 6-thioguanine resistance (hgprt locus) were measured. Survival was enhanced when the cells were irradiated in the presence of dimethyl sulfoxide; the D0 rose from 58 to 107 rad. However, at both genetic loci the induced mutant fractions were identical in the presence or absence of dimethyl sulfoxide. Survival was enhanced to a greater degree when the cells were irradiated in the presence of cysteamine; the D0 rose from 58 to 200 rad. Cysteamine also protected the cells from X-ray-induced mutation; the frequencies of X-ray-induced mutation at both the tk and hgprt loci were reduced by 50-75%. No protective effects were observed unless dimethyl sulfoxide or cysteamine was present during irradiation. These findings are discussed in terms of the hypothesis that, unlike for cell killing, radiation-induced mutagenesis in human lymphoblast cells is not mediated by the actions of aqueous free radicals, but rather by the direct effects of ionizing radiation.
An Incentive Regulation of Access Charges under Incomplete Information (2007)

This paper considers an incentive regulation in the telecommunications industry with respect to the sale of retail and access services. This regulation scheme induces the monopoly carrier who owns bottleneck facilities to adopt socially optimal outcomes when providing access and retail services. It is well known that upstream carriers can realize an integrated level of profit, without integration, by means of a two-part tariff. First, this paper introduces a framework for regulating an access and retail price combined with budget balancing. Second, this paper introduces two-part tariff (price discrimination) scheme for both access (upstream) and retail (downstream) services and discusses the resulting implications for incentive regulation when the regulator has incomplete information about cost functions. By imposing a self-selection mechanism, the regulator can induce firms to adopt socially optimal prices in both access and retail markets.
Development and Application of SAW Filter (2022)

With the in-depth advancement of the fifth generation (5G) mobile communication technology, the technical requirements for filters are also constantly improving. Surface acoustic wave (SAW) filters are widely used in home TV, mobile communications, radio frequency filters and radar due to their simple structure, few mask layers, easy miniaturization, and low cost. Through the continuous improvement of communication technology, SAW has developed into various high-performance acoustic filters from bulk SAW with the support of some new architectures, new materials and advanced modeling techniques. This paper analyzes and reviews the research situation of SAW filter technology.
PriA helicase and SSB interact physically and functionally (2004)

PriA helicase is the major DNA replication restart initiator in Escherichia coli and acts to reload the replicative helicase DnaB back onto the chromosome at repaired replication forks and D-loops formed by recombination. We have discovered that PriA-catalysed unwinding of branched DNA substrates is stimulated specifically by contact with the single-strand DNA binding protein of E.coli, SSB. This stimulation requires binding of SSB to the initial DNA substrate and is effected via a physical interaction between PriA and the C-terminus of SSB. Stimulation of PriA by the SSB C-terminus may act to ensure that efficient PriA-catalysed reloading of DnaB occurs only onto the lagging strand template of repaired forks and D-loops. Correlation between the DNA repair and recombination defects of strains harbouring an SSB C-terminal mutation with inhibition of this SSB-PriA interaction in vitro suggests that SSB plays a critical role in facilitating PriA-directed replication restart. Taken together with previous data, these findings indicate that protein-protein interactions involving SSB may coordinate replication fork reloading from start to finish.
Mercuric iodide single crystals for nuclear radiation detectors (1996)

Large size HgI/sub 2/ single crystals were grown using the modified temperature oscillation method with low dislocation densities in a relatively stable temperature environment. Radiation detectors were fabricated from the single crystals which showed good energy resolution with small polarization.