gebhart/patrepeval huggingface dataset:
Single‐step Production of Photocatalytic Surfaces via Direct Laser Interference Patterning of Titanium (2023)

Abstract State of the art approaches to produce photocatalytic surfaces generally require multiple processing steps to achieve highly active surfaces. Following recent trends to facilitate the production of active surfaces, this work presents a single‐step method to create porous photocatalytic surfaces via direct laser interference patterning (DLIP) of a titanium substrate with pulses in the picosecond range. The resulting surfaces contain a variety of titanium oxides while both their composition and morphology can be controlled through the laser process parameters. This makes it possible to tailor these surfaces for specific applications such as antimicrobial surfaces, implant materials or water treatment. Surface characterization was executed by applying scanning electron microscopy complemented by focused ion beam cross‐sectioning and energy dispersive X‐ray spectroscopy as well as gracing incidence X‐ray diffractometry. The photocatalytic activity achieved by different laser parameters is assessed by methylene blue degradation under UV‐A light. As DLIP is already established in industrial applications, this approach could greatly facilitate the use of photocatalytic surfaces for water treatment or medical applications, as it does not require nanoparticle synthesis or additional coating steps.
Changes in synovial fluid biomarkers and clinical efficacy of intra‐articular injections of hyaluronic acid for patients with knee osteoarthritis (2014)

Our findings speculate that HA injections significantly modulate levels of intra articular biomarkers which may indicate beneficial effect for articular cartilage and synovium membrane.
The Effects of Technology-Assisted Listening Practice on Moodle on English-Majored Freshmen’s Motivation for Learning Listening at a University in The Mekong Delta (2023)

Purpose: This study was to investigate the effects of technology-assisted listening practice on MOODLE on English-majored freshmen's motivation for learning English listening at a university in the Mekong Delta. Approach/Methodology/Design: Two groups of sixty-four mixed-gender freshmen majoring in English language studies participated in this quasi-experimental study. To collect data, a pre-questionnaire, a post-questionnaire, and interviews were employed. Findings: The findings indicated that technology-assisted listening practice on MOODLE improved English-majored freshmen's listening motivation in specific areas for learning listening; however, this was a variance development. Practical Implications: This study was aimed to help language teachers and students benefit from technology-assisted listening teaching and learning. Originality/value: This study innovates by applying the MOODLE system to increase students’ listening motivation at a university in the Mekong Delta.
A Hierarchical Correlation Model for Evaluating Reliability, Performance, and Power Consumption of a Cloud Service (2015)

Cloud computing is a new emerging technology aimed at large-scale resource sharing and service-oriented computing. To achieve the efficient use of cloud resources for supporting a cloud service, many important factors need to be considered, particularly, reliability, performance, and power consumption of the cloud service. Evaluation of these metrics is essential for further designing rational resource scheduling strategies. However, these metrics are closely related; they do affect one another. The cloud system should consider correlations among the metrics to make more precise evaluation. Most of the existing approaches and models handle these metrics separately, and thus they cannot be used to study the correlations. This paper presents a new hierarchical correlation model for analyzing and evaluating these correlated metrics, which encompasses Markov models, queuing theory, and a Bayesian approach. Various distinctive characteristics of the cloud system are investigated and captured in the model, such as multiple virtual machines (VMs) hosted on the same server, common cause failures of co-located VMs caused by server failures, and logical mapping mechanisms for multicore CPUs. Moreover, for evaluating and balancing the tradeoff between performance and power consumption, a tradeoff parameter and a pure profit optimization model are developed based on the presented correlation model. Numerical examples are provided.
Fundamentals and technology of wafer drying (2011)

The commercial rotary dryers used to dry wood wafers (of approximate dimensions 0.63 mm thick, 50 mm wide and 76+ mm long) for the production of panelboard are modified versions of agricultural dryers and have not been designed for the optimal drying of wood wafers. The lack of available information on wafer drying necessitated that the first goal of this research was the characterization of wafer drying behaviour. After the important parameters of wafer drying were identified, the applicability of fluidized bed technology to wafer drying was assessed and an industrial size dryer was designed. The proposed fluidized bed wafer dryer was then compared to a commercial rotary dryer in terms of energy efficiency. Wafer drying behaviour was investigated in two factorial experiments. Three lengths of wafers (25 mm, 44 mm and 63 mm) were individually dried in a 0.15 m draft tube at temperatures of 90°C, 120°C and 150°C. The statistical analysis of the resultant drying rate curves showed that the drying behaviour of aspen wafers was influenced by the effect of wafer length on the external heat and mass transfer rates to the wafer surface, and on the length of internal pathways for bulk flow and diffusion of water. The external drying conditions had a decreasing effect on drying rate until about 10% moisture content at which time drying became limited by internal heat and mass transport. The initial assessment of fluidized bed technology for wafer drying used a 0.15 m semi-cylindrical column for the determination of wafer drying rate curves and wafer behaviour in a fluidized bed of inert particulate solids at excess superficial velocities of 0.25 to 1.0 m/s. Wafer drying times in a bed of 0.5 mm sand at 150°C were about 40% of the drying times for wafers dried by forced convection of air at the same temperature and twice the superficial velocity (~ 1 m/s). Wafer movement in the fluidized bed followed the circulation patterns of the emulsion phase and was thus dependent on the bubbling behaviour of the bed. A minimum excess superficial velocity of 0.25 m/s (depending on distributor design) was required to prevent permanent settling of the wafers to the distributor. Preliminary experimentation on a 2-compartment bed showed that wafers could be circulated through the two compartments in near plug flow. However, the application of this technique to a 4-compartment continuous fluidized bed wafer dryer was unsuccessful because of the separation of sand and wafers caused by slugging beds in two of the compartments. A preliminary design was prepared for an industrial size, 5-compartment fluidized bed wafer dryer to approximate plug flow of wafers by a series of well-mixed fluidized beds in series. The design calculations showed that this dryer was more efficient in terms of energy and plant space than a conventional triple pass rotary dryer.
Effect of cA2 Anti–Tumor Necrosis Factor-α Antibody Therapy on Hematopoiesis of Patients with Myelodysplastic Syndromes (2006)

The encouraging biological insights from cA2 administration may be useful in conducting further clinical trials using cA2 for selected MDS patients, particularly those with evidence of immune-mediated inhibition of hematopoiesis.
Design criteria for phase sequences in selected mapping (2004)

Multicarrier code division multiple access (MC-CDMA) has attracted much attention to the fourth generation mobile communication systems, because it can realize high-bit-rate and high capacity transmission by multiplexing information symbols of many users with orthogonal codes. One disadvantage of multicarrier modulation is its high peak-to-average power ratio (PAPR) that results in nonlinear distortion at a high power amplifier (HPA) and the degradation of the bit error rate (BER). Various methods have been proposed for reducing PAPR. Among them, partial transmit sequences (PTS) and selected mapping (SLM) have been investigated intensively. PTS and SLM have been applied to MC-CDMA. We showed that SLM is more effective than PTS at the same amount of side information. We also showed that the random sequences can reduce the PAPR most as phase sequences in SLM by computer simulation. However, it has not been clarified why the random sequences are good as phase sequences in SLM and how we should design phase sequences in SLM. In this paper, we propose design criteria for phase sequences in SLM.
Effect of recombinant alpha-interferon on pharmacokinetics, biodistribution, toxicity, and efficacy of 131I-labeled monoclonal antibody CC49 in breast cancer: a phase II trial. (1997)

Preclinical studies have demonstrated that recombinant IFN-alpha (rIFN-alpha) can enhance the tumor associated glycoprotein 72 (TAG-72) on tumors. To determine whether rIFN-alpha could enhance TAG-72 expression in vivo in patients, 15 women with breast cancer were randomized to receive daily injections of rIFN-alpha (3 x 10(6) units/m2 for 14 days) beginning on day 1 (group 1 = 7 patients) or on day 6 (group 2 = 8 patients). On day 3, all patients received a 10-20-mCi tracer dose of 131I-CC49, a high-affinity murine monoclonal antibody reactive against TAG-72, followed by a therapy dose of 60-75 mCi/m2 of 131I-CC49 on day 6. Whole body and single-photon emission computed tomography scans along with whole blood pharmacokinetics were performed following tracer and treatment phases. Hematological toxicity was considerable; reversible grade 3-4 neutropenia and thrombocytopenia was observed in 12 of 15 patients. Twelve of 14 patients tested developed human antimouse antibodies 3-6 weeks after treatment. For group 1 patients, whole blood residence time increased significantly between that predicted from the tracer doses and therapy doses (42.6 +/- 4.7 versus 51.5 +/- 4.8 h, respectively; P < 0.01). The calculated radiation absorbed dose to red marrow from therapy compared to tracer activity was also significantly higher for this group (1.25 +/- 0.35 versus 1. 07 +/- 0.26 cGy/mCi; P < 0.05). Treatment with rIFN-alpha was found to enhance TAG-72 expression in tumors from patients receiving rIFN-alpha (group 1) by 46 +/- 19% (P < 0.05) compared to only 1.3 +/- 0.95% in patients not initially receiving IFN (group 2). The uptake of CC49 in tumors was also significantly increased in rIFN-alpha-treated patients. One partial and two minor tumor responses were seen. In summary, rIFN-alpha treatment altered the pharmacokinetics and tumor uptake of 131I-CC49 in patients at the expense of increased toxicity.
Three-Dimensional Patterning of Poly(Ethylene Glycol) Hydrogels Through Surface-Initiated Photopolymerization (2008)

Photopolymerizable hydrogels have been investigated extensively for biomedical applications, specifically in the area of tissue engineering. While fabrication approaches have shown promise in designing hydrogel scaffolds that guide cell function, the ability to spatially control localization in three-dimensions has been limited. We have developed a method for generating two-dimensional and three-dimensional (3D) patterns within multilayered poly(ethylene glycol) diacrylate (PEG-DA) hydrogels. Covalently attached hydrogel layers are formed using precursor solutions with a 10:1 mole ratio of PEG-DA to PEG-aminoacrylate (Acr-PEG-NH2). Upon illumination of the precursor with visible light (wavelength = 514 nm), a hydrogel layer forms with pendant amine groups induced by the presence of Acr-PEG-NH2 macromer. Pendant amine groups are further functionalized with free carboxyl groups present on the visible light photoinitiator eosin, allowing for the formation of subsequent hydrogel layers. Using noncontact photolithography, the prepolymer solution is polymerized through a photomask, resulting in hydrogel structures with distinct pattern formation in each layer. Unreacted regions immobilized with eosin can be subsequently filled with a different PEG hydrogel. The technique presented shows a great potential for tissue engineering applications, for biosensors, and in the formation of cell and protein patterning for biotechnology.
The Mammalian Testis-Specific Thioredoxin System (2004)

Redox control of cell physiology is one of the most important regulatory mechanisms in all living organisms. The thioredoxin system, composed of thioredoxin and thioredoxin reductase, has emerged as a key player in cellular redox-mediated reactions. For many years, only one thioredoxin system had been described in higher organisms, ubiquitously expressed in the cytoplasm of eukaryotic cells. However, during the last decade, we and others have identified and characterized novel thioredoxin systems with unique properties, such as organelle-specific localization in mitochondria or endoplasmic reticulum, tissue-specific distribution mostly in the testis, and features novel for thioredoxins, such as microtubule-binding properties. In this review, we will focus on the mammalian testis-specific thioredoxin system that comprises three thioredoxins exclusively expressed in spermatids (named Sptrx-1, Sptrx-2, and Sptrx-3) and an additional thioredoxin highly expressed in testis, but also present in lung and other ciliated tissues (Txl-2). The implications of these findings in the context of male fertility and testicular cancer, as well as evolutionary aspects, will be discussed.
Preeclampsia is associated with hypermethylation of IGF-1 promoter mediated by DNMT1. (2018)

Previous studies have demonstrated a dynamic epigenetic regulation of genes expression in placenta trophoblasts and a dynamic imbalance of DNA methylation and hydroxymethylation. Reduced IGF-1 has been observed in preeclampsia. This study was to investigate the interactive roles between IGF-1 and the global DNA methylation/hydroxymethylation, and the status of DNA methylation/hydroxymethylation and associated enzymes such as DNMTs and TETs in peeeclamptic placentas and hypoxic trophoblasts. It was found that IGF-1 was decreased in preeclamptic placentas and hypoxic trophoblasts when compared to the control group using immunohistochemisty, western blot, qRT-PCR and ELISA. Pyrophosphate sequencing showed IGF-1 promoter was significantly hypermethylated in preeclamptic placentas, which was responsible for reduced IGF-1 expression. Preeclamptic placentas and hypoxic trophoblasts were hypermethylated and hypohydroxymethylated accompanied by remarkably higher 5mC, DNMT1 and DNMT3b, and lower DNMT3a, 5hmC, TET1, TET2 and TET3 detected by immunohistochemisty, western blot, qRT-PCR and ELISA. Pearson's correlation confirmed a statistically significant negative correlation between IGF-1 and DNMT1. Furthermore, both treatment with 5-Aza-dc and DNMT1-siRNA significantly increased the expression of IGF-1 in HTR8 cells, indicating the potential mechanism of DNMT1-mediated DNA methylation in IGF-1 regulation. However, IGF-1 didn't change DNA methylation or hydroxymethylation. These findings suggest that preeclampsia is associated with hypermethylation of IGF-1 promoter mediated by DNMT1 and provide new insights into the diagnosis and treatment of preeclampsia.
Pathologist variation in reporting cervical borderline epithelial abnormalities and cervical intraepithelial neoplasia. (1995)

The current guidelines for the histological diagnosis of cervical intraepithelial neoplasia and BAUS are poorly reproducible.
Calcium-Binding Properties of Wild-Type and EF-Hand Mutants of S100B in the Presence and Absence of a Peptide Derived from the C-Terminal Negative Regulatory Domain of p53 (2005)

S100B is a dimeric Ca(2+)-binding protein that undergoes a 90 +/- 3 degrees rotation of helix 3 in the typical EF-hand domain (EF2) upon the addition of calcium. The large reorientation of this helix is a prerequisite for the interaction between each subunit of S100B and target proteins such as the tumor suppressor protein, p53. In this study, Tb(3+) was used as a probe to examine how binding of a 22-residue peptide derived from the C-terminal regulatory domain of p53 affects the rate of Ca(2+) ion dissociation. In competition studies with Tb(3+), the dissociation rates of Ca(2+) (k(off)) from the EF2 domains of S100B in the absence and presence of the p53 peptide was determined to be 60 and 7 s(-)(1), respectively. These data are consistent with a previously reported result, which showed that that target peptide binding to S100B enhances its calcium-binding affinity [Rustandi et al. (1998) Biochemistry 37, 1951-1960]. The corresponding Ca(2+) association rate constants for S100B, k(on), for the EF2 domains in the absence and presence of the p53 peptide are 1.1 x 10(6) and 3.5 x 10(5) M(-)(1) s(-)(1), respectively. These two association rate constants are significantly below the diffusion control ( approximately 10(9) M(-)(1) s(-)(1)) and likely involve both Ca(2+) ion association and a Ca(2+)-dependent structural rearrangement, which is slightly different when the target peptide is present. EF-hand calcium-binding mutants of S100B were engineered at the -Z position (EF-hand 1, E31A; EF-hand 2, E72A; both EF-hands, E31A + E72A) and examined to further understand how specific residues contribute to calcium binding in S100B in the absence and presence of the p53 peptide.
Evaluating memory-hard proof-of-work algorithms on three processors (2020)

Most public blockchain systems, exemplified by cryptocurrencies such as Ethereum and Monero, use memory-hard proof-of-work (PoW) algorithms in consensus protocols to maintain fair participation without a trusted third party. The memory hardness, or the amount of memory access, of these PoW algorithms is to prevent the dominance of custom-made hardware of massive computation units, in particular, application-specific integrated circuit (ASIC) and field-programmable gate array (FPGA) machines, in the system. However, it is unclear how effective these algorithms are on general-purpose processors. In this paper, we study the performance of representative memory-hard PoW algorithms on the CPU, the Graphics Processing Unit (GPU), and the Intel Knights Landing (KNL) processors. We first optimize each algorithm for individual processors, and then measure their performance with number of threads and memory size varied. Our experimental results show that (1) the GPU dominates the CPU and the KNL processors on each algorithm, (2) all algorithms scale well with number of threads on the CPU and KNL, and (3) the size of accessed memory area affects each algorithm differently. Based on these results, we recommend CryptoNight with scratchpads of different sizes as the most egalitarian PoW algorithm.
Evaluating the Post-Delivery Fault Reporting and Correction Process in Closed-Source and Open-Source Software (2007)

Post-delivery fault reporting and correction are important activities in the software maintenance process. It is worthwhile to study these activities in order to understand the difference between open-source and closed-source software products from the maintenance perspective. This paper proposes three metrics to evaluate the post-delivery fault reporting and correction process, the average fault hidden time, the average fault pending time, and the average fault correction time. An empirical study is further performed to compare the fault correction processes of NASA Ames (closed-source) projects and three open-source projects: Apache Tomcat, Apache Ant, and Gnome Panel.
Adaptive sparse matrix-matrix multiplication on the GPU (2019)

In the ongoing efforts targeting the vectorization of linear algebra primitives, sparse matrix-matrix multiplication (SpGEMM) has received considerably less attention than sparse Matrix-Vector multiplication (SpMV). While both are equally important, this disparity can be attributed mainly to the additional formidable challenges raised by SpGEMM.
Practical Applications of Time-lapse Seismic Data (2013)

Time-lapse (4D) seismic technology is a key enabler for improved hydrocarbon recovery and more cost-effective field operations. Practical Applications of Time-lapse Seismic Data (SEG Distinguished Instructor Series No. 16) shows how 4D seismic data are used for reservoir surveillance, how they provide valuable insight on dynamic reservoir properties such as fluid saturation, pressure, and temperature, and how they add value to reservoir management. The material, based on the 2013 SEG Distinguished Instructor Short Course, includes discussions of reservoir-engineering concepts and rock physics critical to the understanding of 4D data, along with topics in 4D seismic acquisition and processing. A primary focus of the book is interpretation and data integration. Case-study examples are used to demonstrate key concepts and are drawn on to demonstrate the range of interpretation methods currently employed by industry and the diversity of geologic settings and production scenarios in which 4D is making a difference. Time-lapse seismic interpretation is inherently integrative, drawing on geophysical, geologic, and reservoir-engineering data and concepts. As a result, this book should be of interest to individuals from all subsurface disciplines.
Application of foamed additives to the surface of wet handsheets (2021)

We explored the application of foamed wet-end additives onto wet handsheets to qualify our method of application and to demonstrate the method’s usefulness for prescreening additives and foaming agents for packaging applications. We modified a laboratory drawdown coating machine to allow coating of wet handsheets with foamed additives. Initial sheet solids were adjusted to a target of 8%–25% by vacuum. Foam layer thickness was set mechanically. After application, the foamed additives were drawn into the sheet with vacuum. The additive dosage was adjusted by altering its concentration within the foaming formulation. We evaluated more than 100 foaming agents and 10 strength additives, comparing wet-end and foam-assisted addition with no addition on recycled linerboard and virgin linerboard furnish. Foam-assisted addition typically displayed a much steeper dose-response curve and much higher maximum strength levels than wet-end addition. Our results suggest potential target applications for this technology, such as lightweighting, and improved strength performance in mills with relatively closed water systems, where strength aids added into the wet end are adversely influenced by accumulation of inorganic ions and organic species.
Kinetics Comparisons of Mammalian Atg4 Homologues Indicate Selective Preferences toward Diverse Atg8 Substrates (2010)

The Atg4 cysteine proteases are required for processing Atg8 for the latter to be conjugated to phosphatidylethanolamine on autophagosomal membranes, a key step in autophagosome biogenesis. Notably, whereas there are only one atg4 and one atg8 gene in the yeast, the mammals have four Atg4 homologues and six Atg8 homologues. The Atg8 homologues seem to play different roles in autophagosome biogenesis, and previous studies had indicated that they could be differentially processed by Atg4 homologues. The present study provided the first detailed kinetics analysis of all four Atg4 homologues against four representative Atg8 homologues. The data indicated that Atg4B possessed the broadest spectrum against all substrates, followed by Atg4A, whereas Atg4C and Atg4D had minimal activities as did the catalytic mutant of Atg4B (C74S). On the other hand, GATE-16 seemed to be the overall best substrate for Atg4 proteases. The kinetics parameters of Atg4B were also affected by its structure and that of the substrates, indicating a process of induced fit. The determination of the kinetics parameters of the various Atg4-Atg8 pairs provides a base for the understanding of the potential selective impact of the reaction on autophagosome biogenesis.