gebhart/patrepeval huggingface dataset:
A dynamic model‐based approach to motion and deformation tracking of prosthetic valves from biplane x‐ray images (2018)

The proposed algorithm could be used to generate 3D visualization of the prosthetic valve from two projections. In combination with soft-tissue sensitive-imaging techniques like transesophageal echocardiography, this technique could enable 3D image guidance during TAVR procedures.
Intent-aware search result diversification (2011)

Search result diversification has gained momentum as a way to tackle ambiguous queries. An effective approach to this problem is to explicitly model the possible aspects underlying a query, in order to maximise the estimated relevance of the retrieved documents with respect to the different aspects. However, such aspects themselves may represent information needs with rather distinct intents (e.g., informational or navigational). Hence, a diverse ranking could benefit from applying intent-aware retrieval models when estimating the relevance of documents to different aspects. In this paper, we propose to diversify the results retrieved for a given query, by learning the appropriateness of different retrieval models for each of the aspects underlying this query. Thorough experiments within the evaluation framework provided by the diversity task of the TREC 2009 and 2010 Web tracks show that the proposed approach can significantly improve state-of-the-art diversification approaches.
Footpad dermatitis in poultry (2010)

Footpad dermatitis (FPD) is a condition that causes necrotic lesions on the plantar surface of the footpads in growing broilers and turkeys. This condition not only causes downgrades and condemnations of saleable chicken paws, the portion of the leg below the spur, but is also an animal welfare concern in both the United States and in Europe.. Revenue from chicken paws in 2008 alone was worth $280 million. Harvesting large, unblemished paws has become a priority to poultry companies all over the world. Research on this subject has been ongoing since the 1940s and has looked into many different areas including nutrition, environment, and genetics. Early research looked at nutritional deficiencies such as riboflavin and biotin mainly in turkey poults. This early research was most likely looking at a separate form of dermatitis than what is being investigated now. Recent findings have suggested that there is a myriad of interacting factors that lead to FPD. Litter moisture appears to be the most likely culprit in the onset of this condition. Research has also shown a possible genetic link in the susceptibility to development of FPD lesions. Current chicken paw prices have skyrocketed due to a large export market in Asia. To produce unblemished paws for both increased profit and comply with current animal welfare recommendations, further research is needed to understand how the condition develops and what strategies can be used to prevent it.
Heparin Derivatives of High Molecular Weight (1978)

Heparin methacrylate is polymerized in 1,4-dioxane solution by heating with azodiisobutyronitrile as catalyst. TABLE I ANTILIPEMIC ACTIVITY AND THROMBIN TIME AFTER INTRAVENOUS INJECTION OF 1 mg/kg HEPARIN OR HEPARIN POLYMER IN RATS TABLE II ANTILIPEMIC ACTIVITY AND THROMBIN TIME AFTER INTRAVENOUS INJECTION OF 2 mg/kg HEPARIN OR HEPARIN POLYMER IN RABBITS 4Circular dichroism data in water (0.75 mg/mL) of heparin (I), methacrylated heparin polymer (II), and co-polymer of methacrylated heparin with butyl methacrylate (III) Depending on the degree of polymerization, soluble of gelatinous heparin preparations of high molecular weight are obtained, and separated on a column of Sephadex G-200 from unchanged heparin. A higher degree of polymerization of heparin methacrylate with alkyl methacrylates or vinyl derivatives resulted in liposoluble heparin preparations. Copolymerization with such reticulants as divinylbenzene or N,N'-methylene-bisacrylamide changed completely the geometry of the molecule. Circular dichroism measurements were used to follow the structural change of heparin methacrylate polymer and of its copolymer with butyl methacrylate. Some of the high molecular weight heparin preparations show a dissociation between the anticoagulant and antilipemic activities of heparin: the antithrombic activity decreased, while the antilipemic activity increased considerably or remained unchanged. In soluble heparin preparations can be used for coating of surfaces.
Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study (2019)

Findings support the usefulness of a criterion-based interview approach to assess and quantify SCD in the context of AD and validate the current SCD-plus features as predictors of AD pathology. While some features seem to be more closely associated with AD biomarkers than others, aggregated scores over several SCD-plus features or SCD domains may be the best predictors of AD pathology.
Recent advances in mechanical properties of anisotropic conductive adhesive film for microelectronic packaging (2015)

Purpose – This review paper aims to provide a better understanding of formulation and processing of anisotropic conductive adhesive film (ACF) material and to summarize the significant research and development work for the mechanical properties of ACF material and joints, which helps to the development and application of ACF joints with better reliability in microelectronic packaging systems. Design/methodology/approach – The ACF material was cured at high temperature of 190°C, and the cured ACF was tested by conducting the tensile experiments with uniaxial and cyclic loads. The ACF joint was obtained with process of pre-bonding and final bonding. The impact tests and shear tests of ACF joints were completed with different aging conditions such as high temperature, thermal cycling and hygrothermal aging. Findings – The cured ACF exhibited unique time-, temperature- and loading rate-dependent behaviors and a strong memory of loading history. Prior stress cycling with higher mean stress or stress amplitude restrained the ratcheting strain in subsequent cycling with lower mean stress or stress amplitude. The impact strength and adhesive strength of ACF joints increased with increase of bonding temperature, but they decreased with increase of environment temperature. The adhesive strength and life of ACF joints decreased with hygrothermal aging, whereas increased firstly and then decreased with thermal cycling. Originality/value – This study is to review the recent investigations on the mechanical properties of ACF material and joints in microelectronic packaging applications.
Evidence for redundancy in cysteine biosynthesis in Rhizobium leguminosarum RL3841: analysis of a cysE gene encoding serine acetyltransferase The GenBank accession number for the sequence reported in this paper is AJ271648. (2001)

A cysE gene encoding a serine acetyltransferase (SAT) potentially involved in the biosynthesis of cysteine was identified approximately 4 kb upstream of the previously described aapJQMP gene cluster that encodes an amino acid permease in Rhizobium leguminosarum strain 3841. The gene exhibits >40% identity to the family of SATs containing N-terminal extensions that have been described for other bacteria and plants. The ORF has three possible translation initiation sites which potentially encode polypeptides of 311, 277 and/or 259 amino acid residues, respectively. All three ORFs complemented the cysE mutation in an Escherichia coli cysteine auxotroph, strain JM39. Insertion of Tn5-lacZ into cysE in the genome of R. leguminosarum (strain RU632) lowered SAT activity in crude extracts by >95%. However, RU632 was not a cysteine auxotroph, which suggests that R. leguminosarum possesses some redundancy in cysteine biosynthesis. Additional copies of cysE could not be detected in the genome when the R. leguminosarum cysE gene was used as a hybridization probe. Therefore it is possible that R. leguminosarum possesses an alternative pathway for cysteine biosynthesis which avoids O-acetylserine. Strain RU632 was unaffected in its ability to nodulate Pisum sativum, and the nodules were effective for N(2) fixation (measured by C(2)H(2) reduction). Transcriptional activity of cysE was determined by measuring the beta-galactosidase arising from cysE::Tn5-lacZ fusions. Maximal levels of expression were observed during early exponential growth and were not influenced by the level of sulphur (supplied as sulphate). However, transcription was repressed by approximately twofold in ammonium-grown, as opposed to glutamate-grown, cultures. Repression by ammonium was not seen in a strain defective for ntrC.
User Story based Information Visualization Type Recommendation System (2019)

To help users to determine the most appropriate visualization type is a useful feature of business visualization tools. Existing systems often give preliminary suggestions based on data sources but usually cannot make practical final decision. User stories are generalizations of user requirements. To recommend visualization type based on user stories can make better use of human experience to achieve automated decision making. One approach discussed in the paper is using machine learning techniques to model existing visualization types with corresponding user stories, and then use this model to predict recommended visualization type for new user story. This paper designs and implements a recommendation system prototype ReViz to verify the feasibility of this approach. As a typical web application, Modeling, Input Processing and Predicting components of ReViz are programmed using Python with Flask framework and Anaconda package set, and user interface is implemented using HTML, JavaScript and CSS with Bootstrap front-end library. The evaluation results show that ReViz can give recommended visualization type based on user story keywords. As a data-based intelligent software development technology achievement, visualization type recommendation system can also be integrated into larger business information management systems.
Immunostimulant Activity Of Inulin Isolated From Saussurea Lappa Roots (2001)

Polyfructoscan, inulin was extracted from the dried roots of Saussurea Iappa. The crude inulin obtained was purified by fractional recrystallization using ethanol. lnulin was characterized by IR, NMR, DSC and X-ray diffraction studies. The fructose content in inulin isolated from Saussurea lappa roots was quantitatively estimated to be 95.89% w/w. lnulin in the insoluble form was found to significantly potentiate the delayed type hypersensitivity response to SRBC and also Increase the total WBC count.
Facile Synthesis of Highly Water-Soluble Fullerenes More Than Half-Covered by Hydroxyl Groups (2008)

Using a novel hydrogen peroxide heating method, we synthesized milky white, water-soluble polyhydroxylated fullerenes (fullerenols) with 36-40 hydroxyl groups (estimated average) along with 8-9 secondary bound water molecules. The fullerenols exhibited high water solubility up to 58.9 mg/mL in a neutral (pH = 7) condition. Dynamic light scattering analysis showed a high dispersion property, to give a narrow particle size distribution within 0.7-2.0 nm.
Correlation of Magnetic Resonance Imaging Tumor Volume with Histopathology (2012)

Magnetic resonance imaging can accurately estimate index tumor volume as determined by histology. Magnetic resonance imaging has better accuracy in predicting histopathology tumor volume in tumors larger than 0.5 cm(3) than prostate specific antigen and age. Index tumor volume as determined by magnetic resonance imaging may be helpful in planning treatment, specifically in identifying tumor margins for image guided focal therapy and possibly selecting better active surveillance candidates.
Anti‐tumor activity of daunorubicin linked to poly‐<scp>L</scp>‐aspartic acid (1982)

Daunorubicin was bound to poly-L-aspartic acid via the methylketone side chain of the drug to avoid reaction of the sugar amino group believed to be essential for optimal drug activity. Attachment of the drug to the polyamino acid by an ester linkage was achieved by nucleophylic substitution reaction of 14-bromo-daunorubicin. Compared with free daunorubicin, the polymeric derivative was less cytotoxic to HeLa cells in vitro, but more effective against all tumor models tested (P388 leukemia, Gross leukemia, MS-2 sarcoma). The binding to the polypeptide markedly reduced drug toxicity but only slightly decreased drug potency. The daunorubicin-poly-L-aspartic acid conjugate demonstrated antitumor activity comparable to that of doxorubicin in leukemia models, but superior to that of doxorubicin in a solid tumor model (MS-2 sarcoma).
Synthesis of Novel Fluorescent Benzothiazole Cyanine Dyes as Potential Imaging Agents (2022)

Near-infrared (NIR) fluorescence imaging has emerged as an attractive non-invasive approach for direct visualization of diseases which depends on the development of stable, highly specific and sensitive optical probes. The NIR region of the electronic spectrum offers a reduction in the background autofluorescence and an increase in the tissue penetration depth. Cyanine dyes have often been considered promising contrast optic agents owing to their photophysical properties. Herein the synthesis of various penta- and heptamethine benzothiazole cyanine dyes has been described and their in vivo imaging efficacy was determined. Varying functionalities on the benzothiazole aromatic ring and changing substituents on the benzothiazolium nitrogen atom reflected subsequent changes in the imaging pattern and have resulted in the development of promising brain targeting agents.
A Foreground-background Parallel Compression with Residual Encoding for Surveillance Video (2020)

The data storage has been one of the bottlenecks in surveillance systems. The conventional video compression algorithms such as H.264 and H.265 do not fully utilize the low information density characteristic of the surveillance video. In this paper, we propose a video compression method that extracts and compresses the foreground and background of the video separately. The compression ratio is greatly improved by sharing background information among multiple adjacent frames through an adaptive background updating and interpolation module. Besides, we present two different schemes to compress the foreground and compare their performance in the ablation study to show the importance of temporal information for video compression. In the decoding end, a coarse-to-fine two-stage module is applied to achieve the composition of the foreground and background and the enhancements of frame quality. Furthermore, an adaptive sampling method for surveillance cameras is proposed, and we have shown its effects through software simulation. The experimental results show that our proposed method requires 69.5% less bpp (bits per pixel) than the conventional algorithm H.265 to achieve the same PSNR (36 dB) on the HECV dataset.
Arrestin Function in Inactivation of G Protein-Coupled Receptor Rhodopsin in Vivo (1993)

Arrestins have been implicated in the regulation of many G protein-coupled receptor signaling cascades. Mutations in two Drosophila photoreceptor-specific arrestin genes, arrestin 1 and arrestin 2, were generated. Analysis of the light response in these mutants shows that the Arr1 and Arr2 proteins are mediators of rhodopsin inactivation and are essential for the termination of the phototransduction cascade in vivo. The saturation of arrestin function by an excess of activated rhodopsin is responsible for a continuously activated state of the photoreceptors known as the prolonged depolarized afterpotential. In the absence of arrestins, photoreceptors undergo light-dependent retinal degeneration as a result of the continued activity of the phototransduction cascade. These results demonstrate the fundamental requirement for members of the arrestin protein family in the regulation of G protein-coupled receptors and signaling cascades in vivo.
Experimental Comparison between Hybrid-QPSK/8QAM and 4D-32SP-16QAM Formats at 31.2 GBaud using Nyquist Pulse Shaping (2013)

We report on the performance comparison between two modulation formats carrying each 2.5 bits per transmitted 2D-symbol. Using Nyquist pulse shaping and a 33-GHz spacing grid, we show that the 4D-32SP-16QAM format outperforms the Hybrid-QPSK/8QAM format over a transmission link made of standard single mode fiber.
Purity and Content of a Sweetener, Acesulfame Potassium, and Their Test Methods. (2000)

アセスルファムカリウムの規格作成のための試験法について検討し, 試供品に適用した. 試験法はJECFA及びFCCの方法を大きく変える必要はなかった. 4ロットの試供品について, 性状, 極大吸収, 沈殿反応, フッ化物, 紫外線吸収不純物, 乾燥減量, 及び含量について測定したところ, JECFA及びFCCの規格に適合した. pHを第7版食品添加物公定書に準じて測定したところpH5.75～5.83で, FCC規格 (6.5～7.5) より酸性を示したが, 脱二酸化炭素水を用いることにより6.71～6.99を示し, FCC規格に適合した. 含量は99.6～100.3%であった.
Peptide Immobilization on Amine-Terminated Boron-Doped Diamond Surfaces (2007)

This paper reports on the formation and characterization of semicarbazide termination on aminated boron-doped diamond (BDD) surfaces, and further preparation of peptide microarray through site-specific alpha-oxo semicarbazone ligation. Hydrogen-terminated BDD electrodes were first aminated using NH3 plasma treatment and then reacted with triphosgene and Fmoc-protected hydrazine to yield a protected semicarbazide termination. Subsequent deprotection and chemical reaction with glyoxylyl peptides led to the covalent immobilization of the peptides on the surface through site-specific ligation. The resulting surfaces were characterized using X-ray photoelectron spectroscopy (XPS) and fluorescence measurements.
vNFC: A Virtual Networking Function Container for SDN-Enabled Virtual Networks (2012)

Software-defined networks (SDN) has gradually been deployed on commercial networks such as datacenter networks. Current SDN is based on OpenFlow technology that is a set ofnetwork flow control API for switch devices. For instance, network reachability between end-hosts (or virtual machines), packet filtering mechanisms, and status management of switches are enabled by the API. In practice, however, current OpenFlow-based SDN has following problems: no application-layer protocol support and switch-oriented flow control. Since OpenFlow targets L2-L4 flow handling, users have to arrange additional mechanism for upper-layer flow control. Furthermore, executing a lot of flow matching on a single switch (or virtual switch) can cause difficulty in network trace and overall performance degradation.This paper proposes a virtual networking function container (vNFC) that is a set of software implemented networking functions for VM-to-VM communications, and it is located between a virtual machine and a virtual network device of the host machine. vNFC enables not only lower-layer functions OpenFlow providing, but also upper-layer functions like application firewall in the same manner. That is, vNFC is a virtual machine dedicated flow handling function set. In addition, OpenFlow-compatible vNFC configuration protocol named OpenNF and vNFC controller are also presented. OpenNF provides communication path between each networking function and the controller for configuration and decision making.In this paper, architectural design and implementation of vNFC are presented, and also performance evaluation of using vNFC. The evaluation result shows that a lightweight networking function does not impact on the performance, but a function that frequently communicates with the controller incurs millisecond order cost per frame transmission.
A Structure-Activity Relationship Study of Benzylic Modifications of 4-[1-(1-Naphthyl)ethyl]-1H-imidazoles on .alpha.1- and .alpha.2-Adrenergic Receptors (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Structure-Activity Relationship Study of Benzylic Modifications of 4-[1-(1-Naphthyl)ethyl]-1H-imidazoles on .alpha.1- and .alpha.2-Adrenergic ReceptorsSeoung-Soo Hong, Karl J. Romstedt, Dennis R. Feller, Fu-Lian Hsu, Thomas L. Cupps, Robert A. Lyon, and Duane D. MillerCite this: J. Med. Chem. 1994, 37, 15, 2328–2333Publication Date (Print):July 22, 1994Publication History Published online1 May 2002Published inissue 22 July 1994https://pubs.acs.org/doi/10.1021/jm00041a011https://doi.org/10.1021/jm00041a011research-articleACS PublicationsRequest reuse permissionsArticle Views483Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
R)CCA Secure Updatable Encryption with Integrity Protection. (2019)

An updatable encryption scheme allows a data host to update ciphertexts of a client from an old to a new key, given so-called update tokens from the client. Rotation of the encryption key is a common requirement in practice in order to mitigate the impact of key compromises over time. There are two incarnations of updatable encryption: One is ciphertext-dependent, i.e. the data owner has to (partially) download all of his data and derive a dedicated token per ciphertext. Everspaugh et al. (CRYPTO’17) proposed CCA and CTXT secure schemes in this setting. The other, more convenient variant is ciphertext-independent, i.e., it allows a single token to update all ciphertexts. However, so far, the broader functionality of tokens in this setting comes at the price of considerably weaker security: the existing schemes by Boneh et al. (CRYPTO’13) and Lehmann and Tackmann (EUROCRYPT’18) only achieve CPA security and provide no integrity protection. Arguably, when targeting the scenario of outsourcing data to an untrusted host, plaintext integrity should be a minimal security requirement. Otherwise, the data host may alter or inject ciphertexts arbitrarily. Indeed, the schemes from BLMR13 and LT18 suffer from this weakness, and even EPRS17 only provides integrity against adversaries which cannot arbitrarily inject ciphertexts. In this work, we provide the first ciphertext-independent updatable encryption schemes with security beyond CPA, in particular providing strong integrity protection. Our constructions and security proofs of updatable encryption schemes are surprisingly modular. We give a generic transformation that allows key-rotation and confidentiality/integrity of the scheme to be treated almost separately, i.e., security of the updatable scheme is derived from simple properties of its static building blocks. An interesting side effect of our generic approach is that it immediately implies the unlinkability of ciphertext updates that was introduced as an essential additional property of updatable encryption by EPRS17 and LT18.
Chemistry of ginkgolides: structure–activity relationship as PAF antagonists (1999)

Abstract