gebhart/patrepeval huggingface dataset:
On the performance of GSM/EDGE transmit diversity schemes when employing dual-polarized antennas (2004)

Base station antennas with cross-polarized antenna branches are commonly used in mobile communication systems. It is known that the use of vertically and horizontally polarized base station antennas results in unbalance between received powers in mobile station, while the channels corresponding to /spl plusmn/45/spl deg/ slanted, linearly polarized antennas are correlated. In this paper, we calculate the power unbalance and correlation between the channels in terms of channel cross-polarization and base station antenna properties. Furthermore, link level performance of transmit diversity techniques, suitable to GSM/EDGE radio access network, is simulated.
Highly ionized Ar plasma waveguides generated by a fast capillary discharge (2005)

Highly ionized Ar plasma channels were created by a fast capillary discharge and used to guide laser pulses with peak intensities up to 2.2/spl times/10/sup 17/ W/cm/sup 2/ over a 5.5-cm distance. These plasmas are of interest for the generation of efficient soft X-ray lasers by longitudinal laser excitation. The guides were characterized using plasma interferometry, modeling, and near field imaging.
An Intrinsic Mode Function based energy detector for spectrum sensing in cognitive radio (2017)

In this paper, the filtering characteristics of Empirical Mode Decomposition (EMD) are used to create a blind and adaptive energy detector for single or multi-channel spectrum sensing. EMD is an adaptive tool that decomposes time-series signals into a set of modes called Intrinsic Mode Functions (IMF). Due to the EMD filtering behavior, the first IMF is mostly contaminated by noise from the received noisy signal. The proposed approach takes advantage of Cell Averaging Constant False Alarm Rate (CA-CFAR) as an optimal detector to enhance the probability of detection. Alternative to conventional CA-CFAR (which requires at least one nearby vacant channel for good noise estimation), the first IMF will be used as a training function for noise estimation purposes. Based on the first IMF characteristics in frequency domain, the noise floor of the received signal is estimated and a threshold is derived for a given false alarm rate. Simulations show the improvement of the proposed detector in comparison with other conventional detectors.
Intelligent Network Virtualization in Flexible Grid Optical Networks (2015)

Software-defined flexible grid optical networks enable new revenue opportunities through delivery of virtual optical network (VON) services. This paper showcases an intelligent VON mapper capable of simultaneously and efficiently mapping large number of VON demands.
Tuning the energy gap of conjugated polymer zwitterions for efficient interlayers and solar cells (2014)

ABSTRACT Narrow band gap conjugated polymer zwitterions (CPZs) were synthesized by Suzuki polymerization and characterized to understand their electronic properties and utility as cathode modification layers in solar cells. The polymers were prepared from diketopyrrolopyrrole (DPP) and iso ‐indigo monomers containing sulfobetaine (SB) pendant groups, benefiting from an ion‐rich aqueous phase in the polymerizations. UV–vis absorption spectroscopy revealed the optical energy gap value for the CPZs, ranging from 1.7 to 1.2 eV. Ultraviolet photoelectron spectroscopy of the CPZs as thin layers on Ag metal showed that the pendent zwitterions impart an interfacial dipole (Δ) to the metal and a work function reduction of ∼0.9 eV. OPVs fabricated using a conventional bulk heterojunction (BHJ) device architecture of ITO/PEDOT:PSS/(PTB7:PC 71 BM)/CPZ/Ag led to dramatic improvements in power conversion efficiency (PCE) values relative to devices having bare Ag cathodes (PCE < 2% for bare Ag vs. 6.7–7.7% for CPZ/Ag). The benzothiadiazole (BT)/DPP polymer denoted as PT 2 BTDPPSB gave an optimal PCE of 7.7% in a conventional BHJ OPV device architecture fabricated on a Ag cathode. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53 , 327–336
TMEM16A/ANO1: Current Strategies and Novel Drug Approaches for Cystic Fibrosis (2021)

Cystic fibrosis (CF) is the most common of rare hereditary diseases in Caucasians, and it is estimated to affect 75,000 patients globally. CF is a complex disease due to the multiplicity of mutations found in the CF transmembrane conductance regulator (CFTR) gene causing the CFTR protein to become dysfunctional. Correctors and potentiators have demonstrated good clinical outcomes for patients with specific gene mutations; however, there are still patients for whom those treatments are not suitable and require alternative CFTR-independent strategies. Although CFTR is the main chloride channel in the lungs, others could, e.g., anoctamin-1 (ANO1 or TMEM16A), compensate for the deficiency of CFTR. This review summarizes the current knowledge on calcium-activated chloride channel (CaCC) ANO1 and presents ANO1 as an exciting target in CF.
Contribution of the Conserved Amino Acids of the Melanocortin-4 Receptor in d-[Nle4,Phe7]-α-Melanocyte-stimulating Hormone Binding and Signaling (2007)

Melanocortin 4 receptor (MC4R) plays an important role in the regulation of food intake and body weight. To determine the molecular basis of human MC4R (hMC4R) responsible for alpha-melanocortin-stimulating hormone (alpha-MSH) binding, in this study, we utilized both receptor domain exchange and site-directed mutagenesis studies to investigate the molecular determinants of hMC4R responsible for alpha-MSH binding and signaling. alpha-MSH is a potent agonist at hMC4R but not at hMC2R. Cassette substitutions of the second, third, fourth, fifth, and sixth transmembrane regions (TM) of the hMC4R with the homologous regions of hMC2R were performed and alpha-MSH binding and signaling were examined. Our results indicate that each chimeric receptor was expressed at the cell surface and the expression levels remain similar to that of the wild-type receptor. The cassette substitutions of the second, fourth, fifth, and sixth TMs of the hMC4R with homologous regions of the hMC2R did not significantly alter alpha-MSH binding affinity and potency except substitution of the TM3 of the hMC4R, suggesting that the conserved residues in TMs of the hMC4R are crucial for alpha-MSH binding and signaling. Further mutagenesis studies indicate that conserved residues Glu(100) in TM2, Asp(122), Asp(126) in TM3 and Trp(258), Phe(261), His(264) in TM6 are involved in alpha-MSH binding and signaling. In conclusion, our results suggest that the conserved residues in the TM2, TM3, and TM6 of the hMC4R are responsible for alpha-MSH binding and signaling.
Part 2: Solvent management: solvent stability and amine degradation in CO<sub>2</sub>capture processes (2011)

Solvent stability in CO2 capture from industrial flue gases is one of the most significant parameters that needs to be closely monitored to maintain the highest efficiency in the carbon CO2 absorption operation. Amines used in the capture process are known to degrade, resulting in the most serious degree of solvent loss in CO2 capture from flue gases. Reactive constituents in flue gas, specifically O2, SO2, nitrogen oxides (NOx) and inorganic oxide fly ash, competitively react with amines, leading to irreversible decomposition of amine into various degradation products. Because of degradation, the absorption efficiency deteriorates and corrosion problems occur. In this article, we review research activities in amine degradation from past to present for CO2 and sulfur compound-induced degradation. Research conducted on oxidative degradation of amines before and after 2000 is also reviewed, including our works undertaken at the International Test Centre for CO2 Capture and works by other researchers.
Preliminary results for the phase 1 trial of a folate receptor alpha adjuvant cancer vaccine in ovarian and endometrial cancer patients (2013)

Meeting abstracts Folate Receptor Alpha (FRa) is an immunogenic protein that is over-expressed in breast, endometrial and ovarian cancer (OC). In fact, FRa expression in malignant cells is 20-fold higher compared to normal cells. We have begun a phase 1 clinical trial with E39, an HLA-A2 restricted
Herpes Simplex Virus 1 Glycoprotein M and the Membrane-Associated Protein UL11 Are Required for Virus-Induced Cell Fusion and Efficient Virus Entry (2013)

Herpes simplex virus 1 (HSV-1) facilitates virus entry into cells and cell-to-cell spread by mediating fusion of the viral envelope with cellular membranes and fusion of adjacent cellular membranes. Although virus strains isolated from herpetic lesions cause limited cell fusion in cell culture, clinical herpetic lesions typically contain large syncytia, underscoring the importance of cell-to-cell fusion in virus spread in infected tissues. Certain mutations in glycoprotein B (gB), gK, UL20, and other viral genes drastically enhance virus-induced cell fusion in vitro and in vivo. Recent work has suggested that gB is the sole fusogenic glycoprotein, regulated by interactions with the viral glycoproteins gD, gH/gL, and gK, membrane protein UL20, and cellular receptors. Recombinant viruses were constructed to abolish either gM or UL11 expression in the presence of strong syncytial mutations in either gB or gK. Virus-induced cell fusion caused by deletion of the carboxyl-terminal 28 amino acids of gB or the dominant syncytial mutation in gK (Ala to Val at amino acid 40) was drastically reduced in the absence of gM. Similarly, syncytial mutations in either gB or gK did not cause cell fusion in the absence of UL11. Neither the gM nor UL11 gene deletion substantially affected gB, gC, gD, gE, and gH glycoprotein synthesis and expression on infected cell surfaces. Two-way immunoprecipitation experiments revealed that the membrane protein UL20, which is found as a protein complex with gK, interacted with gM while gM did not interact with other viral glycoproteins. Viruses produced in the absence of gM or UL11 entered into cells more slowly than their parental wild-type virus strain. Collectively, these results indicate that gM and UL11 are required for efficient membrane fusion events during virus entry and virus spread.
Anticoagulant Peptides; Synthesis, Stability and Antithrombin Activity of Hirudin C-Terminal-Related Peptides and Their Disulfated Analog. (1996)

We designed a unique anticoagulant decapeptide, which possesses two O-sulfated tyrosine residues, based on the structure of hirudin's C-terminal functional domain. We first prepared a series of octa-, nona- and decapeptides with no sulfation, Suc-Phe-Glu-Pro-Ile-Pro-Glu-Tyr-Tyr-X-OH [X = bond, Leu or Leu-Gln], by a solution phase method and measured their thrombin times (TT) using human thrombin and rabbit plasma. The shortest octapeptide (3a) showed full antithrombin activity comparable to that of the lead compound hirudin (54-65), and the longest decapeptide (3c) prolonged TT most potently with an IC50 value of 5.8 microM. We consequently converted 3c to a disulfated decapeptide (NF-22) with SO3.pyridine complex and compared its antithrombin activity with that of known hirudin-related peptides: hirugen, MDL28050 and hirulog-1. NF-22 showed potent antithrombin activity with an IC50 value of 0.3 microM, being more potent than hirugen and MDL28050 (IC50 values of 4.0 microM and 1.1 microM, respectively). NF-22 was as potent as hirulog-1. NF-22 showed no change in activity in aqueous solution for 10 d at 60 degrees C, and remained about 90% unchanged in rat plasma on incubation for 24h at 37 degrees C, whereas the corresponding unsulfated peptide (3c) was completely digested under the same condition. NF-22 appears to be one of the most potent and stable peptide anticoagulants among the hirudin analogs.
Data from Genes Associated with Prostate Cancer Are Differentially Expressed in African American and European American Men (2023)

<div>Abstract<p><b>Background:</b> Despite more aggressive screening across all demographics and gradual declines in mortality related to prostate cancer (PCa) in the United States, disparities among populations persist. A substantial proportion of African American men (AAM) have a higher overall incidence, earlier age of onset, increased proportion of clinically advanced disease, and increased bone metastases and mortality from PCa compared to European American men (EAM). Limited early evidence indicates that underlying causes for disparities may be observed in tumor-specific gene expression programs.</p><p><b>Methods:</b> This study used microarray-based methods to measure expression levels for 517 genes that were previously associated with PCa in archived formalin-fixed paraffin embedded (FFPE) specimens; testing the hypothesis that gene expression features of functional consequence to cancer distinguish PCa from AAM and EAM. A <i>t</i> test was conducted comparing AAM to EAM expression levels for each probe on the array.</p><p><b>Results:</b> Analysis of 639 tumor samples (270 AAM, 369 EAM) showed that 95 genes were overexpressed specifically in PCa from AAM relative to EAM and 132 were overexpressed in PCa from EAM relative to AAM. Furthermore, systems-level analyses highlight the relevant signaling pathways and functions associated with the EAM- or AAM-specific overexpressed gene sets, for example, inflammation and lipid metabolism.</p><p><b>Conclusions:</b> Results here bring further understanding to the potential for molecular differences for PCa in AAM versus EAM.</p><p><b>Impact:</b> The results support the notion that therapeutic benefits will be realized when targeted treatments are designed to acknowledge and address a greater spectrum of PCa subtypes and molecular distinctions. <i>Cancer Epidemiol Biomarkers Prev; 22(5); 891–7. ©2013 AACR</i>.</p></div>
PCAOT: A Manhattan Point Cloud Registration Method Towards Large Rotation and Small Overlap (2018)

Point cloud registration is a popular research topic and has been widely used in many tasks, such as robot mapping and localization. It is a challenging problem when the overlap is small, or the rotation is large. The problem has not been well solved by existing methods such as the iterative closest point (ICP) and its variants. In this paper, a novel method named principal coordinate alignment with overlap tuning (PCAOT) is proposed based on the Manhattan world assumption. It solves two key problems together, the transformation estimation and the overlap estimation. The overlap is represented by a 3D cuboid and the transformation is computed only within the overlap region. Instead of finding point correspondence as in traditional methods, we estimate the rotation by principal coordinates alignment, which is faster and less sensitive than ICP and its variants to small overlaps and large rotations. Evaluations demonstrate that our method achieves much better results than the ICP and its variants when the overlap ratio is smaller than 50%, or the rotation angle is larger than 60°. Especially, it is effective when the overlap ratio is less than 30%, or the rotation angle is larger than 90°.
Cognitive, psychiatric and motor response to galantamine in Parkinson's disease with dementia (2003)

Although controlled trials are needed, the findings suggest that galantamine is useful in patients with PDD.
Device for inhibiting no/sub chi/ formation by a combustion system (1988)

This patent describes a combustion system for a gas-fired furnace comprising, in combination: a monoport inshot gas burner, the burner is a two-zone combustion type burner and the combustion zone of the combustion flame includes a primary combustion zone and a secondary combustion zone surrounding the primary combustion zone, a heat exchanger defining a flow path for combustion products, the heat exchanger having an inlet and an outlet, the burner being disposed external to the heat exchanger at the inlet, the combustion flame is projected through the inlet into the heat exchanger, and a device positioned within the heat exchanger and extending in the direction of the flow path for inhibiting formation of oxides of nitrogen by controlling peak combustion flame temperatures and residence times at the peak flame temperatures, the device including at least one piece of material positioned at the periphery of the secondary combustion zone and outside the combustion zone and configured in a longitudinal relationship to the combustion flame to allow the device to absorb thermal energy from the periphery of the secondary combustion zone at a rate which limits peak flame temperatures to levels which inhibit formation of oxides of nitrogen while allowing substantially completemore » combustion of the gaseous fuel supplied to the burner.« less
Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrument† (2000)

The frequency-domain multiple-distance (FDMD) method is capable of measuring the absolute absorption and reduced scattering coefficients of optically turbid media. Absolute measurement of absorption at two near-infrared (NIR) wavelengths makes possible the quantitation of tissue haemoglobin concentration and tissue haemoglobin oxygen-saturation (StO2). However, errors are introduced by the uncertainties of background absorption and the dissimilarities between real tissues and the simplified mathematical model on which these measurements are based. An FDMD-based tissue instrument has been used for the monitoring of tissue haemoglobin concentration and oxygenation in the brain of newborn piglets during periods of hypoxia and hyperoxia. These tissue haemoglobin saturation values were compared with arterial saturation (SaO2) and venous saturation (SvO2) measured by blood gas analyses. A linear correlation was observed between StO2 and the average of SaO2 and SvO2. However, StO2 is not equal to any fixed weighted average of SaO2 and SvO2 unless we introduce an effective background tissue absorption. The magnitude of the background absorption was about 0.08 cm(-1) at 758 nm and 0.06 cm(-1) at 830 nm, and it was nearly consistent between piglets. The origin of this 'effective' background absorption may be real, an artefact caused by the application of a simplified model to a complex sample, or a combination of factors.
Live Respiratory Syncytial Virus (RSV) Vaccine Candidate Containing Stabilized Temperature-Sensitivity Mutations Is Highly Attenuated in RSV-Seronegative Infants and Children (2018)

NCT01852266 and NCT01968083.
Variable frequency characteristic circuit for a vehicular sound device (1991)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Akira Kanagawa, Hiroshi Hattori; Variable frequency characteristic circuit for a vehicular sound device. J. Acoust. Soc. Am. 1 May 1991; 89 (5): 2490. https://doi.org/10.1121/1.400886 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Barrier matching for programs with textually unaligned barriers (2007)

Barriers, a common synchronization primitive in SPMD-style programs, are used to partition a program into a sequence of parallel phases. Popular parallel programming models, such as MPI and OpenMP, allow barriers to be textually unaligned. Textually unaligned barriers make it difficult for the programmer to understand the synchronization phases in the program, and they can easily lead to synchronization errors. In this paper, we present an interprocedural analysis for matching barriers in a program in order to detect synchronization errors, or, if no such errors exist, to determine the synchronization phases of the program. Our analysis uses a combination of path expressions and interprocedural program slicing to match synchronizing barrier statements. If the barrier matching succeeds, the analysis determines the sets of barrier statements that synchronize together. A matching failure indicates the presence of a synchronization error and the analysis constructs a counter example to illustrate the error. We have implemented the analysis in an MPI checker tool for programs written in C and successfully analyzed the synchronization structure of several MPI benchmarks.
Flexural‐Torsional Photomechanical Responses in Azobenzene‐Containing Crosslinked Polyimides (2012)

Abstract The influence of a variety of factors on the photomechanical output of azo‐CP2‐ xx systems is studied, primarily focusing on a sample with a higher crosslink density (30 mol%) and two new, structurally related crosslinked polyimides with modified backbone flexibility/rigidity. This work elucidates the strong coupling between geometrical considerations (reciprocal aspect ratio of cantilever) and the visualized mechanical response (e.g., flexural‐torsional response of a cantilever). magnified image
Cell Cycle-dependent Chronic Infection of Human Cytomegalovirus in Human Osteogenic Sarcoma Cells (1979)

SUMMARY Human osteogenic sarcoma cells transformed by murine sarcoma virus (R970) showed restricted growth of human cytomegalovirus (HCMV). Virus was attached to the same extent as in human fibroblasts. HCMV growth was blocked at early stages after virus penetration. Splitting of infected R970 cultures resulted in infection of all cells. In experiments using synchronized R970 cells it was found that factor(s) associated with the S-phase of the cell cycle might be necessary for establishment of the infection.
Metabolic engineering of Escherichia coli for the production of isoprenoids (2018)

Metabolic engineering is the practice of using directed genetic manipulations to rewire cellular metabolism primarily with the aim to transform the organism into a single-celled chemical factory. Using biological processes, we can produce more complex chemicals in a more sustainable way. This is particularly important for chemicals which are hard to synthesize using traditional chemistry. However, cells have evolved for growth and must be engineered to produce a single chemical at commercially viable levels. This review focuses on the strategies used to rewire cellular metabolism to produce chemicals using isoprenoid production in Escherichia coli as an example that illustrates many of the challenges faced in metabolic engineering.
Hang analysis (2008)

Soft hang is an action that was expected to respond instantly but instead drives an application into a coma. While the application usually responds eventually, users cannot issue other requests while waiting. Such hang problems are widespread in productivity tools such as desktop applications; similar issues arise in server programs as well. Hang problems arise because the software contains blocking or time-consuming operations in graphical user interface (GUI) and other time-critical call paths that should not. This paper proposes HangWiz to find hang bugs in source code, which are difficult to eliminate before release by testing, as they often depend on a user's environment. HangWiz finds hang bugs by finding hang points: an invocation that is expected to complete quickly, such as a GUI action, but calls a blocking function. HangWiz collects hang patterns from runtime traces supplemented with expert knowledge, and feed these patterns into a static analysis framework that searches exhaustively for hang points that involve potential hang bugs. Experiments with several large, real-world software packages (including a source control client, a graphics editor and a web server) show that there are several hang bugs in these applications, and that HangWiz is effective in finding them. The experiments also demonstrate that HangWiz is scalable and can analyze millions of lines of code. We further discuss related techniques and report our experience on fixing hang bugs.